Dose-Response Assay Compilation

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Last updated: 2021-03-08

Checks: 6 1

Knit directory: toxin_dose_responses/

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Untracked files:
    Untracked:  data/drugclasses.csv
    Untracked:  output/Aldicarb_EC10.csv
    Untracked:  output/Aldicarb_EC50.csv
    Untracked:  output/Aldicarb_EC90.csv
    Untracked:  output/Arsenic trioxide_EC10.csv
    Untracked:  output/Atrazine_EC10.csv
    Untracked:  output/Atrazine_EC50.csv
    Untracked:  output/Cadmium dichloride_EC10.csv
    Untracked:  output/Cadmium dichloride_EC50.csv
    Untracked:  output/Cadmium dichloride_EC90.csv
    Untracked:  output/Carbaryl_EC10.csv
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    Untracked:  output/Carboxin_EC10.csv
    Untracked:  output/Carboxin_EC50.csv
    Untracked:  output/Carboxin_EC90.csv
    Untracked:  output/Chlorfenapyr_EC10.csv
    Untracked:  output/Chlorfenapyr_EC50.csv
    Untracked:  output/Chlorfenapyr_EC90.csv
    Untracked:  output/Chlorpyrifos_EC10.csv
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    Untracked:  output/Chlorpyrifos_EC90.csv
    Untracked:  output/Copper(II) chloride_EC10.csv
    Untracked:  output/Copper(II) chloride_EC50.csv
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    Untracked:  output/Lead(II) nitrate_EC10.csv
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    Untracked:  output/Methylmercury dichloride_EC10.csv
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    Untracked:  output/Nickel dichloride_EC10.csv
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    Untracked:  output/Paraquat_EC10.csv
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    Untracked:  output/Pyraclostrobin_EC10.csv
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    Untracked:  output/Pyraclostrobin_EC90.csv
    Untracked:  output/Silver nitrate_EC10.csv
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    Untracked:  output/Triphenyl phosphate_EC10.csv
    Untracked:  output/Triphenyl phosphate_EC50.csv
    Untracked:  output/Triphenyl phosphate_EC90.csv
    Untracked:  output/Zinc dichloride_EC10.csv
    Untracked:  output/Zinc dichloride_EC50.csv
    Untracked:  output/Zinc dichloride_EC90.csv
    Untracked:  output/cv.control.wells.csv

Unstaged changes:
    Modified:   analysis/doseresponsemodels.Rmd

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These are the previous versions of the repository in which changes were made to the R Markdown (analysis/toxin8strains.Rmd) and HTML (docs/toxin8strains.html) files. If you’ve configured a remote Git repository (see ?wflow_git_remote), click on the hyperlinks in the table below to view the files as they were in that past version.

File	Version	Author	Date	Message
html	cb6e132	sam-widmayer	2021-03-06	Build site.
Rmd	46c9647	sam-widmayer	2021-03-06	static working directory
Rmd	41bdaa0	sam-widmayer	2021-03-05	dynamic working directory
Rmd	0c9d312	sam-widmayer	2021-03-05	initiate toxin DRC analysis repo

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Purpose:

• Compile past assay results.
• Provide dose-response curves for each toxin.

Analysis Date: March 08, 2021

Assay Summary

Past versions of “Assay Diagnostics-1.png”

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

   Metadata_Experiment bleach    median cv.censor
1             toxin09A      1 0.4002814         0
2             toxin10A      1 0.4197976         0
3             toxin11A      1 0.4367000         0
4             toxin14A      1 0.3306423         0
5             toxin14A      2 0.6350979         1
6             toxin14A      3 0.3307924         0
7             toxin14B      1 0.3537066         0
8             toxin14B      2 0.6953160         1
9             toxin14B      3 0.4131710         0
10            toxin15A      1 0.3776043         0
11            toxin15A      2 0.3253871         0
12            toxin15A      3 0.5951538         1
13            toxin15B      1 0.3060126         0
14            toxin15B      2 0.3803403         0
15            toxin15B      3 0.6178760         1
16            toxin16A      1 0.3058102         0
17            toxin16A      2 0.6505324         1
18            toxin16A      3 0.6474844         1
19            toxin17A      1 0.3215600         0
20            toxin17A      2 0.5741834         1
21            toxin17A      3 0.3411714         0
22            toxin18A      1 0.3136715         0
23            toxin18A      2 0.3292525         0
24            toxin18A      3 0.3363887         0
25            toxin19A      1 0.3300594         0
26            toxin19A      2 0.3203313         0
27            toxin19A      3 0.3406528         0

                         Df Sum Sq Mean Sq F value   Pr(>F)    
assay                    10 1.0900  0.1090   8.912 7.86e-12 ***
as.factor(bleach)         2 0.8644  0.4322  35.341 1.16e-13 ***
strain                    7 0.1209  0.0173   1.412    0.203    
assay:as.factor(bleach)  14 1.7381  0.1241  10.151  < 2e-16 ***
Residuals               179 2.1892  0.0122                     
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Silver

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Cadmium

[1] "Excluding toxin09A: Inconsistent Response"

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Copper

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Nickel

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Paraquat

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Zinc

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Pyraclostrobin

[1] "Excluding toxin11A: Inconsistent Response"

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Aldicarb

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Chlorfenapyr

[1] "Excluding toxin09A, toxin10A, toxin11A, toxin12A: No Response/Variable Dilution"

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

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Methomyl

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Methyl Mercury

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Triphenyl phosphate

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Arsenic trioxide

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Carbaryl

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Carboxin

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Chlorpyrifos

[1] "Excluding toxin17A: No Response"

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Lead (II) nitrate

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cb6e132	sam-widmayer	2021-03-06

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cb6e132	sam-widmayer	2021-03-06

Atrazine

[1] "Excluding toxin16A: Inaccurate Dilution Series"

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cb6e132	sam-widmayer	2021-03-06

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EC Estimates

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EC10

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EC50

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EC90

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Summary Tables

Table: Aldicarb Estimates

Strain   Weibull        Log-Logistic   Lognormal    
-------  -------------  -------------  -------------
ECA396   115.93±10.69   124±10.14      122.69±9.62  
CB4856   117.03±10.86   127.8±10.62    127.06±9.99  
ECA36    141.24±10.94   153.7±10.22    154.55±10.2  
MY16     70.88±6.75     75.61±5.63     75.51±5.4    
XZ1516   88.26±11.96    103.23±12.61   106.18±12.35 
RC301    81.58±6.96     92.4±6.46      92.52±6.19   
PD1074   84.01±5.4      97.64±4.96     98.86±4.84   
ECA248   93.07±10.98    107.73±10.06   109.63±9.68  


Table: Aldicarb Estimates

Strain   Weibull        Log-Logistic   Lognormal    
-------  -------------  -------------  -------------
ECA396   353.62±18.18   348.91±19.81   349.02±20.1  
CB4856   365.8±16.01    359.93±17.68   354.85±17.53 
ECA36    402.54±15.34   393.69±16.57   393.51±16.42 
MY16     207.83±9.88    204.35±10.2    205.21±10.2  
XZ1516   357.4±21       353.31±23.63   345.71±22.67 
RC301    270.2±12.53    263.54±11.81   263.67±11.86 
PD1074   271.33±8.87    263.94±7.88    263.8±7.91   
ECA248   341.91±22.28   330.47±22.2    332.64±21.88 


Table: Aldicarb Estimates

Strain   Weibull        Log-Logistic     Lognormal      
-------  -------------  ---------------  ---------------
ECA396   719.79±61.92   981.75±123.98    992.89±124.08  
CB4856   756.27±56.41   1013.64±113.62   990.99±106.18  
ECA36    784.67±52.68   1008.44±100.63   1001.92±97.57  
MY16     412.5±36.73    552.32±62.14     557.72±61.07   
XZ1516   871.45±90.87   1209.28±200.61   1125.56±172.51 
RC301    579.61±50.43   751.61±77.97     751.39±75.86   
PD1074   572.76±37.1    713.43±52.09     703.89±49.71   
ECA248   783.49±96.35   1013.78±158.22   1009.31±148.09 


Table: Arsenic trioxide Estimates

Strain   Weibull   Log-Logistic   Lognormal     
-------  --------  -------------  --------------
MY16     NA        NA             160.67±145.55 


Table: Atrazine Estimates

Strain   Weibull         Log-Logistic    Lognormal     
-------  --------------  --------------  --------------
PD1074   466.22±485.95   662.6±714.11    NA            
XZ1516   207.41±30.05    247.85±44.5     300.35±107.71 
RC301    157.38±13.76    193.76±23.71    236.31±66.08  
CB4856   133.06±17.69    164.9±28        200.37±69.55  
ECA36    197.93±43.98    263.15±77.94    416.45±311.45 
ECA396   413.79±447.78   679.03±670.12   NA            


Table: Atrazine Estimates

Strain   Weibull         Log-Logistic    Lognormal 
-------  --------------  --------------  ----------
XZ1516   676.67±158.64   882.92±285.38   NA        
RC301    544.44±81.1     751.76±184.58   NA        
CB4856   552.98±129.78   749.71±255.87   NA        
ECA36    779.58±263.89   NA              NA        


Table: Cadmium dichloride Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
MY16     19.92±2.34   20.57±1.96     20.67±1.83 
XZ1516   10.33±2.5    12.47±2.92     14.33±4.63 
PD1074   16.39±1.75   19.05±1.16     19.3±1.08  
ECA36    20.97±1.64   24.52±1.81     25.01±1.72 
ECA396   15.99±1.93   18.92±2.04     19.52±2    
RC301    10.69±1.64   12.36±1.67     12.83±1.69 
ECA248   16.81±1.52   18.47±1.35     19.26±1.33 
CB4856   11.05±1.2    12.87±1.17     13.27±1.14 


Table: Cadmium dichloride Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
MY16     41.49±1.76   40.93±2.13     40.46±2.1  
XZ1516   46.85±6.1    55.93±16.88    50.2±16.01 
PD1074   44.15±2.21   44.39±1.66     44.22±1.67 
ECA36    55.03±2.36   54.13±2.52     53.57±2.39 
ECA396   54.09±3.89   54.06±5.31     53.56±5.21 
RC301    43.69±3.6    45.78±5.62     44.27±5.49 
ECA248   37.6±1.21    37.2±1.4       36.83±1.33 
CB4856   35.98±1.7    36.37±2.06     35.61±1.96 


Table: Cadmium dichloride Estimates

Strain   Weibull        Log-Logistic   Lognormal     
-------  -------------  -------------  --------------
MY16     66.21±4.67     81.46±9.25     79.22±8.77    
XZ1516   122.8±32.08    NA             175.85±157.81 
PD1074   83.04±10.75    103.44±9.94    101.36±9.18   
ECA36    101.77±7.44    119.52±14.24   114.74±12.02  
ECA396   117.63±14.09   154.43±35.58   146.92±32.59  
RC301    107.18±14.34   169.53±46.87   152.77±42.7   
ECA248   62.81±3.46     74.92±7.04     70.43±6.13    
CB4856   76.33±6.98     102.75±14.5    95.62±12.4    


Table: Carbaryl Estimates

Strain   Weibull         Log-Logistic    Lognormal     
-------  --------------  --------------  --------------
RC301    134.99±12.32    184.75±27.65    266.56±104.72 
MY16     102.4±4.79      118.9±4.6       122.84±4.38   
XZ1516   120.84±5.65     141.47±5.76     147.81±6.37   
PD1074   405.97±331.53   712.34±810.51   NA            
ECA248   187.18±12.14    232.29±23.89    293.36±79.54  
CB4856   189.26±8.34     214.14±8.73     222.86±11.36  
ECA396   109.72±6.31     133.78±8.44     144.31±12.7   
ECA36    189.16±12.29    238.08±26       328.1±114.97  


Table: Carbaryl Estimates

Strain   Weibull         Log-Logistic    Lognormal    
-------  --------------  --------------  -------------
RC301    597.55±103.03   974.93±273.99   NA           
MY16     323.94±10.35    359.89±19.57    358.81±22.63 
XZ1516   395.35±19.16    474.18±41.95    500.52±62.33 
ECA248   585.44±71.01    823.18±173.6    NA           
CB4856   484.83±22.64    573.89±50.32    629.52±90.57 
ECA396   418.18±37.57    542.91±85.82    613.2±151.12 
ECA36    595.57±74.55    860.54±189.68   NA           


Table: Carbaryl Estimates

Strain   Weibull         Log-Logistic   Lognormal 
-------  --------------  -------------  ----------
MY16     674.84±39.18    NA             NA        
XZ1516   841.45±68.19    NA             NA        
CB4856   882.94±67.35    NA             NA        
ECA396   981.02±136.95   NA             NA        


Table: Carboxin Estimates

Strain   Weibull        Log-Logistic   Lognormal    
-------  -------------  -------------  -------------
RC301    212.04±13.65   234.24±13.71   237.57±13.49 
MY16     202.22±12.29   221.97±12.01   225.33±11.77 
XZ1516   230.65±16.41   262.22±15.83   265.72±15.34 
PD1074   265.57±24.78   299.98±23.62   308.24±24.92 
ECA248   242.35±20.27   269.74±19.09   273.34±18.4  
CB4856   186.33±14.42   208.58±14.07   212.31±13.49 
ECA396   254.57±12.38   277.82±12.06   281.22±11.85 
ECA36    333.38±25.47   366.64±25.28   369.6±24.67  


Table: Carboxin Estimates

Strain   Weibull        Log-Logistic    Lognormal      
-------  -------------  --------------  ---------------
RC301    483.34±14.87   486.29±18.06    479.67±17.59   
MY16     507.04±15.07   521.11±20.94    512.18±20.92   
XZ1516   613.62±25.4    642.59±36.46    642±40.32      
PD1074   785.46±53.78   942.47±133.32   1011.57±224.12 
ECA248   647.37±32.8    693.17±53.73    692.22±61.91   
CB4856   526.86±22.53   552.68±34.07    542.01±34.73   
ECA396   523.57±12.24   520.83±14.02    516.26±13.63   
ECA36    686.68±28.61   683.94±33.76    678.16±32.9    


Table: Carboxin Estimates

Strain   Weibull          Log-Logistic     Lognormal      
-------  ---------------  ---------------  ---------------
RC301    817.13±44.34     1009.56±92.62    968.46±84.21   
MY16     910.85±48.06     1223.38±118.83   1164.21±111.62 
XZ1516   1144.75±91.47    1574.75±214.79   1551.13±224.94 
PD1074   1567.63±186.59   NA               NA             
ECA248   1210.86±111.8    1781.26±309.62   1753.05±340.02 
CB4856   1021.81±76.81    1464.47±207.55   1383.69±196.76 
ECA396   828.99±33.93     976.38±63.78     947.77±58.3    
ECA36    1088.29±77.32    1275.82±148.06   1244.31±136.71 


Table: Chlorfenapyr Estimates

Strain   Weibull     Log-Logistic   Lognormal 
-------  ----------  -------------  ----------
ECA248   0.18±0.01   0.2±0.01       0.2±0.01  
XZ1516   0.28±0.04   0.3±0.03       0.3±0.03  
ECA36    0.59±0.06   0.66±0.06      0.65±0.05 
CB4856   0.33±0.05   0.32±0.04      0.31±0.03 
ECA396   0.44±0.02   0.49±0.02      0.49±0.01 
PD1074   0.36±0.02   0.34±0.01      0.33±0.01 
RC301    0.2±0.01    0.22±0.01      0.22±0.01 
MY16     0.23±0.02   0.24±0.02      0.24±0.01 


Table: Chlorfenapyr Estimates

Strain   Weibull     Log-Logistic   Lognormal 
-------  ----------  -------------  ----------
ECA248   0.47±0.01   0.45±0.02      0.45±0.01 
XZ1516   0.57±0.02   0.57±0.02      0.57±0.02 
ECA36    1.22±0.04   1.21±0.04      1.2±0.04  
CB4856   0.54±0.02   0.53±0.03      0.52±0.03 
ECA396   0.8±0.02    0.75±0.02      0.75±0.02 
PD1074   0.58±0.01   0.58±0.01      0.58±0.01 
RC301    0.44±0.01   0.42±0.01      0.42±0.01 
MY16     0.51±0.02   0.5±0.02       0.49±0.02 


Table: Chlorfenapyr Estimates

Strain   Weibull     Log-Logistic   Lognormal 
-------  ----------  -------------  ----------
ECA248   0.87±0.05   1.05±0.08      1.01±0.07 
XZ1516   0.89±0.11   1.08±0.12      1.07±0.11 
ECA36    1.93±0.19   2.21±0.21      2.2±0.18  
CB4856   0.74±0.05   0.88±0.09      0.88±0.1  
ECA396   1.16±0.04   1.15±0.07      1.15±0.06 
PD1074   0.79±0.03   1.01±0.05      1.03±0.04 
RC301    0.72±0.02   0.83±0.04      0.8±0.04  
MY16     0.85±0.05   1.04±0.08      1.01±0.07 


Table: Chlorpyrifos Estimates

Strain   Weibull       Log-Logistic   Lognormal 
-------  ------------  -------------  ----------
RC301    15.65±69.09   NA             NA        
XZ1516   2.55±0.16     2.96±0.21      3.21±0.41 
PD1074   0.82±0.43     1.94±1.5       7.92±10.3 
ECA248   2.35±1.85     4.2±3.8        NA        
CB4856   4.55±8.28     7.2±7.15       NA        
ECA396   1.16±1.01     2.2±2.14       7.53±13.2 
ECA36    1.67±0.15     2.08±0.25      2.49±0.55 
MY16     NA            10.98±21.5     NA        


Table: Chlorpyrifos Estimates

Strain   Weibull       Log-Logistic   Lognormal  
-------  ------------  -------------  -----------
XZ1516   6.9±0.54      8.79±1.3       10.87±3.21 
PD1074   18.47±14.33   NA             NA         
ECA396   15.67±18.38   NA             NA         
ECA36    6.96±1.08     9.61±2.2       14.19±6.29 


Table: Chlorpyrifos Estimates

Strain   Weibull      Log-Logistic   Lognormal 
-------  -----------  -------------  ----------
XZ1516   13.01±1.53   NA             NA        
ECA36    17.33±3.6    NA             NA        


Table: Copper(II) chloride Estimates

Strain   Weibull      Log-Logistic   Lognormal   
-------  -----------  -------------  ------------
ECA396   38.22±2.85   40.22±2.52     40.99±2.49  
CB4856   33.35±3.14   35.63±2.77     36.01±2.66  
ECA36    28.16±3.09   31.09±2.82     31.81±2.75  
MY16     53.42±4.22   53.06±3.57     52.31±3.1   
XZ1516   19.81±3.82   26.58±7.63     36.63±25.97 
RC301    38.33±3.77   41.15±3.21     41.82±3.27  
PD1074   43.85±3.58   45.28±3.1      46±2.89     
ECA248   19.1±2       22.47±2.04     23.4±2.11   


Table: Copper(II) chloride Estimates

Strain   Weibull        Log-Logistic   Lognormal   
-------  -------------  -------------  ------------
ECA396   79.69±2.5      79.86±3.53     78.44±3.4   
CB4856   79.65±3.67     82.38±6.2      81.26±6.67  
ECA36    76.39±4.57     81.07±8.44     80.26±9.44  
MY16     89.28±2.17     88.26±2.64     86.9±2.71   
XZ1516   100.33±34.89   159.91±89.98   NA          
RC301    88.99±3.44     97.88±8.19     98.69±12.04 
PD1074   83.46±2.4      82.95±3        81.56±2.89  
ECA248   73.63±7.11     85.96±14.67    89.53±20.86 


Table: Copper(II) chloride Estimates

Strain   Weibull        Log-Logistic   Lognormal    
-------  -------------  -------------  -------------
ECA396   127.28±6.16    158.58±16.06   150.12±14.98 
CB4856   138.71±10.44   190.46±30.78   183.35±32.24 
ECA36    144.28±14.97   NA             NA           
MY16     123.85±4.76    146.81±10.35   144.37±9.75  
RC301    152.22±12.79   NA             NA           
PD1074   125.79±5.29    151.96±12.7    144.63±11.24 
ECA248   173.99±27.81   NA             NA           


Table: Lead(II) nitrate Estimates

Strain   Weibull         Log-Logistic    Lognormal 
-------  --------------  --------------  ----------
ECA36    226.93±128.54   495.47±448.34   NA        


Table: Methomyl Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
ECA396   9.92±0.84    11.24±0.84     11.21±0.82 
CB4856   9.99±1.09    11.16±1.07     11.22±1.05 
ECA36    6.68±0.48    8.13±0.49      8.32±0.49  
MY16     6.69±0.73    8.08±0.77      8.2±0.75   
XZ1516   5.48±0.68    6.77±0.71      6.91±0.7   
RC301    7.35±0.66    8.73±0.67      8.8±0.65   
PD1074   6.38±0.63    7.42±0.65      7.57±0.63  
ECA248   14.13±1.31   15.07±1.13     15.12±1.15 


Table: Methomyl Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
ECA396   35.82±1.47   35.73±1.64     35.2±1.63  
CB4856   31.29±1.48   30.59±1.6      30.2±1.57  
ECA36    33.84±1.25   34.41±1.47     33.95±1.46 
MY16     34.57±2.05   34.78±2.43     34.19±2.39 
XZ1516   30.41±2.23   29.39±2.5      29.33±2.42 
RC301    33.14±1.61   32.82±1.74     32.48±1.71 
PD1074   28.79±1.44   28.29±1.65     27.71±1.58 
ECA248   37.86±1.45   37.64±1.63     37.47±1.64 


Table: Methomyl Estimates

Strain   Weibull       Log-Logistic   Lognormal    
-------  ------------  -------------  -------------
ECA396   81.2±6.08     113.58±12.3    110.57±11.66 
CB4856   64.81±5.25    83.83±10.22    81.28±9.39   
ECA36    95.15±6.65    145.57±15.24   138.64±14.23 
MY16     98.44±10.2    149.79±24.27   142.49±22.54 
XZ1516   90.62±11.43   127.55±24.56   124.47±22.57 
RC301    86.54±7.68    123.4±15.4     119.91±14.35 
PD1074   75.22±6.48    107.94±14.59   101.47±12.92 
ECA248   70.95±5.36    93.99±9.78     92.84±9.75   


Table: Methylmercury dichloride Estimates

Strain   Weibull     Log-Logistic   Lognormal 
-------  ----------  -------------  ----------
ECA396   0.8±0.12    1.04±0.14      1.1±0.14  
CB4856   0.44±0.08   0.62±0.09      0.65±0.09 
ECA36    0.92±0.12   1.2±0.14       1.26±0.14 
MY16     0.43±0.09   0.63±0.12      0.67±0.12 
XZ1516   0.39±0.09   0.55±0.1       0.59±0.1  
RC301    0.84±0.16   1.11±0.19      1.16±0.19 
PD1074   0.91±0.11   1.17±0.13      1.22±0.13 
ECA248   0.25±0.06   0.38±0.08      0.41±0.08 


Table: Methylmercury dichloride Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
ECA396   8.98±0.67    9.54±0.96      9.01±0.9   
CB4856   6.51±0.53    6.96±0.74      6.61±0.7   
ECA36    11.61±0.75   13.15±1.29     12.5±1.3   
MY16     4.35±0.37    4.29±0.41      4.17±0.38  
XZ1516   10.61±1.36   16.84±4.41     17.4±5.98  
RC301    11.88±1.17   14.27±2.3      13.73±2.47 
PD1074   10.46±0.62   11.48±0.96     10.9±0.94  
ECA248   5.76±0.69    6.34±1.07      5.96±1     


Table: Methylmercury dichloride Estimates

Strain   Weibull       Log-Logistic   Lognormal    
-------  ------------  -------------  -------------
ECA396   41.8±5.29     87.51±20.86    73.47±16.79  
CB4856   36.16±5.28    77.96±20.66    67.08±16.91  
ECA36    58.33±6.56    144.01±33.12   124.26±29.32 
MY16     18.96±3.03    29.34±7.43     26.08±6.05   
XZ1516   87.01±20.22   NA             NA           
RC301    64.44±11.37   183.44±70.16   161.97±67.41 
PD1074   49.66±5.16    112.28±22.3    97.14±19.3   
ECA248   42.44±9.09    106.98±42.97   86.84±33.28  


Table: Nickel dichloride Estimates

Strain   Weibull       Log-Logistic   Lognormal     
-------  ------------  -------------  --------------
ECA396   35.82±2.88    39.29±2.52     40.39±2.38    
CB4856   38.06±2.14    40.84±1.84     42.02±1.74    
MY16     31.63±3.53    34.59±3.14     35.29±3.02    
XZ1516   65.3±512.12   91.07±351.16   75.24±156.01  
RC301    23.7±4.54     29.85±7.69     34.54±18.21   
PD1074   39.67±3.31    41.66±2.86     42.16±2.71    
ECA248   29.67±2.38    32.66±2.28     33.18±2.24    
ECA36    NA            NA             153.12±162.41 


Table: Nickel dichloride Estimates

Strain   Weibull        Log-Logistic   Lognormal     
-------  -------------  -------------  --------------
ECA396   68.55±3.03     65.45±3.26     65.29±2.94    
CB4856   72.99±2.01     70.31±2.32     69.75±2.09    
MY16     82.07±5.01     89.07±10.07    88.41±12.01   
RC301    100.97±36.28   140.92±82.27   191.65±236.35 
PD1074   84.23±2.84     86.53±4.58     85.06±4.79    
ECA248   65.68±3.36     62.58±3.8      62.69±3.42    


Table: Nickel dichloride Estimates

Strain   Weibull       Log-Logistic   Lognormal    
-------  ------------  -------------  -------------
ECA396   103.66±6.59   109.03±12.26   105.55±10.09 
CB4856   110.54±4.23   121.04±8.51    115.79±7.01  
MY16     150.67±16.6   NA             NA           
PD1074   136.11±7.77   179.72±21.93   171.61±21.84 
ECA248   108.97±8.6    119.89±16.95   118.46±14.41 


Table: Paraquat Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
MY16     21.04±3.49   29.81±3.67     30.53±3.52 
XZ1516   22.64±6.38   30.97±7.69     32.71±7.94 
CB4856   36.82±5.29   43.06±4.58     43.17±4.32 
RC301    18.65±2.98   24.61±2.98     25.84±2.82 
PD1074   22.06±2.75   31.67±3.07     32.79±2.91 
ECA248   14.21±1.95   20.44±2.12     21.34±2.04 
ECA36    24.14±3.59   34.2±3.87      35.56±3.71 
ECA396   16±2.29      22.15±2.4      23.41±2.31 


Table: Paraquat Estimates

Strain   Weibull        Log-Logistic    Lognormal     
-------  -------------  --------------  --------------
MY16     195.72±21.8    189.38±20.77    195.54±21.95  
XZ1516   376.38±97.98   495.07±211.89   524.09±278.19 
CB4856   181.21±17.65   175.08±15.77    180.18±16     
RC301    196.97±21.97   188.17±24.49    187.59±23.09  
PD1074   237.62±23.93   216.71±23.08    226.89±24.15  
ECA248   167.58±15.99   157.49±16.14    161.09±16.11  
ECA36    225.85±26.21   200.17±24.03    208.98±24     
ECA396   185.66±19.15   162.82±19.49    165.81±18.06  


Table: Paraquat Estimates

Strain   Weibull          Log-Logistic     Lognormal      
-------  ---------------  ---------------  ---------------
MY16     810.74±179.24    1202.92±315.02   1252.61±320.8  
XZ1516   2257.03±934.06   NA               NA             
CB4856   500.28±93.32     711.8±145.09     751.95±146.25  
RC301    884.72±166.79    1438.88±396.38   1361.8±346.34  
PD1074   1080.85±192.09   1482.67±359.1    1569.96±362.65 
ECA248   807.42±139.09    1213.33±285.5    1216.06±268.78 
ECA36    938.96±193.44    1171.47±320.24   1228.27±307.56 
ECA396   885.5±150.85     1196.94±310.29   1174.17±267.38 


Table: Pyraclostrobin Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
ECA396   5.13±0.45    7.01±0.48      7.4±0.47   
CB4856   7.72±1.18    10.95±1.4      11.59±1.39 
ECA36    11.85±0.97   14.8±0.94      15.1±0.92  
MY16     7.6±0.79     10.91±0.93     11.78±0.98 
XZ1516   10.37±1.27   14.64±1.54     15.85±1.71 
RC301    15.04±2.5    19.03±2.54     19.18±2.44 
PD1074   9.09±0.97    12.46±1.09     13.08±1.07 
ECA248   8.59±1.28    12.33±1.54     13.27±1.6  


Table: Pyraclostrobin Estimates

Strain   Weibull        Log-Logistic   Lognormal    
-------  -------------  -------------  -------------
ECA396   79.98±6.64     88.49±9.27     93.88±11.17  
CB4856   121.28±17.04   142.59±28.54   156.05±38.93 
ECA36    79.93±3.6      81.76±4.06     80.96±4.1    
MY16     128.89±14.05   163.22±25.87   185.64±39    
XZ1516   163.82±21.13   220.54±45.46   258.06±75.48 
RC301    101.77±11      102.56±12.01   104.29±12.65 
PD1074   118.27±11.33   136.07±17.63   144.43±22.57 
ECA248   144.56±20.86   181.28±39.94   202.61±59.58 


Table: Pyraclostrobin Estimates

Strain   Weibull         Log-Logistic    Lognormal     
-------  --------------  --------------  --------------
ECA396   460.65±62.67    1116.4±236.96   1191.5±279.08 
CB4856   701.75±165.3    NA              NA            
ECA36    269.73±22.6     451.81±53.31    434.1±50.62   
MY16     783.01±142.39   NA              NA            
XZ1516   951.12±202.66   NA              NA            
RC301    344.23±70.41    552.85±150.04   567.18±153.92 
PD1074   606.82±99.42    1485.41±399.5   NA            
ECA248   873.78±212.8    NA              NA            


Table: Silver nitrate Estimates

Strain   Weibull       Log-Logistic   Lognormal   
-------  ------------  -------------  ------------
MY16     3.6±1.72      7.15±4.63      17.08±30.22 
XZ1516   9.35±4.15     15.53±8.26     28.99±30.86 
ECA36    12.92±9.29    24.37±21.45    93.8±187.3  
ECA396   29.26±34.8    56.67±71.55    NA          
RC301    13.56±12.7    33.27±39.68    NA          
CB4856   19.49±16.06   42.03±42.1     NA          


Table: Silver nitrate Estimates

Strain   Weibull         Log-Logistic   Lognormal 
-------  --------------  -------------  ----------
MY16     107.82±87.15    NA             NA        
XZ1516   163.97±108.06   NA             NA        
ECA36    234.34±231.94   NA             NA        


Table: Triphenyl phosphate Estimates

Strain   Weibull     Log-Logistic   Lognormal 
-------  ----------  -------------  ----------
ECA396   1.63±0.13   2.09±0.15      2.16±0.15 
CB4856   2.1±0.22    2.64±0.25      2.77±0.26 
ECA36    2.06±0.25   2.53±0.27      2.6±0.28  
MY16     0.47±0.06   0.68±0.08      0.73±0.08 
XZ1516   3.15±0.51   3.77±0.57      3.92±0.61 
RC301    2.42±0.37   2.98±0.41      3.11±0.42 
PD1074   3.78±0.35   4.39±0.36      4.49±0.36 
ECA248   1.72±0.17   2.17±0.19      2.24±0.19 


Table: Triphenyl phosphate Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
ECA396   16.43±0.96   21.34±2.16     22.07±2.93 
CB4856   18.33±1.14   21.69±2.26     20.97±2.5  
ECA36    18.31±1.12   22.62±2.53     22.5±3.18  
MY16     11.34±1.15   17.19±3.3      18.03±4.53 
XZ1516   18.96±1.53   20.88±2.51     19.97±2.51 
RC301    15.93±1.14   17.27±1.76     16.66±1.78 
PD1074   19.83±0.92   20.82±1.32     20.1±1.3   
ECA248   16.21±0.89   19.33±1.76     19±2.06    


Table: Triphenyl phosphate Estimates

Strain   Weibull       Log-Logistic   Lognormal    
-------  ------------  -------------  -------------
ECA396   71.51±6.99    NA             NA           
CB4856   72.9±7.86     178.23±41.57   158.68±41.76 
ECA36    73.66±8.5     NA             194.94±62.58 
MY16     86.48±15.06   NA             NA           
XZ1516   59.49±8.4     115.63±33.75   101.68±31.01 
RC301    52.93±7.17    99.95±25.83    89.41±23.5   
PD1074   57.01±4.6     98.74±14.63    90.02±13.34  
ECA248   67.61±6.66    172.04±35.78   161.52±38.98 


Table: Zinc dichloride Estimates

Strain   Weibull       Log-Logistic   Lognormal    
-------  ------------  -------------  -------------
MY16     48.57±3.5     56.71±3.44     60.46±5.29   
PD1074   70.97±20.51   109.35±45.33   NA           
ECA36    61.24±5.44    79.38±11.77    121.2±62.97  
ECA396   38.16±2.41    44.66±2.39     46.35±2.52   
RC301    44.36±3.97    53.44±4.75     60.2±10.72   
ECA248   51.85±3.26    68.24±7.92     107.69±58.09 
XZ1516   NA            55.29±4.08     57.25±4.38   


Table: Zinc dichloride Estimates

Strain   Weibull         Log-Logistic   Lognormal     
-------  --------------  -------------  --------------
MY16     164.68±10.41    210.27±28.6    253.98±68.93  
PD1074   347.13±151.17   NA             NA            
ECA36    228.42±40.02    349.9±105.19   NA            
ECA396   142.89±7.33     172.1±17.01    185.28±28.05  
RC301    167.04±17.09    226.8±46.58    318.12±142.48 
ECA248   205.09±27.2     326.66±86.8    NA            
XZ1516   NA              190.13±26.07   205.76±45     


Table: Zinc dichloride Estimates

Strain   Weibull        Log-Logistic   Lognormal 
-------  -------------  -------------  ----------
MY16     358.56±40.73   NA             NA        
ECA396   331.44±29.33   NA             NA        
RC301    388.87±66.7    NA             NA        

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Session information

sessionInfo()

R version 4.0.4 (2021-02-15)
Platform: x86_64-apple-darwin17.0 (64-bit)
Running under: macOS Catalina 10.15.7

Matrix products: default
BLAS:   /Library/Frameworks/R.framework/Versions/4.0/Resources/lib/libRblas.dylib
LAPACK: /Library/Frameworks/R.framework/Versions/4.0/Resources/lib/libRlapack.dylib

locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] RColorBrewer_1.1-2 RCurl_1.98-1.2     ddpcr_1.15         kableExtra_1.3.4  
 [5] knitr_1.31         drc_3.0-1          MASS_7.3-53        easyXpress_0.1.0  
 [9] forcats_0.5.1      stringr_1.4.0      dplyr_1.0.4        purrr_0.3.4       
[13] readr_1.4.0        tidyr_1.1.2        tibble_3.0.6       ggplot2_3.3.3     
[17] tidyverse_1.3.0    workflowr_1.6.2   

loaded via a namespace (and not attached):
  [1] TH.data_1.0-10        colorspace_2.0-0      ellipsis_0.3.1       
  [4] rio_0.5.16            rprojroot_2.0.2       fs_1.5.0             
  [7] rstudioapi_0.13       farver_2.0.3          fansi_0.4.2          
 [10] mvtnorm_1.1-1         lubridate_1.7.9.2     xml2_1.3.2           
 [13] codetools_0.2-18      splines_4.0.4         readbitmap_0.1.5     
 [16] jsonlite_1.7.2        broom_0.7.5           dbplyr_2.1.0         
 [19] png_0.1-7             compiler_4.0.4        httr_1.4.2           
 [22] backports_1.2.1       assertthat_0.2.1      bmp_0.3              
 [25] Matrix_1.3-2          cli_2.3.1             later_1.1.0.1        
 [28] htmltools_0.5.1.1     tools_4.0.4           igraph_1.2.6         
 [31] gtable_0.3.0          glue_1.4.2            rebus.base_0.0-3     
 [34] Rcpp_1.0.6            carData_3.0-4         cellranger_1.1.0     
 [37] jquerylib_0.1.3       vctrs_0.3.6           svglite_2.0.0        
 [40] xfun_0.21             rebus.datetimes_0.0-1 openxlsx_4.2.3       
 [43] rvest_0.3.6           lifecycle_1.0.0       rebus.numbers_0.0-1  
 [46] gtools_3.8.2          zoo_1.8-8             scales_1.1.1         
 [49] hms_1.0.0             promises_1.2.0.1      sandwich_3.0-0       
 [52] yaml_2.2.1            curl_4.3              sass_0.3.1           
 [55] stringi_1.5.3         imager_0.42.7         highr_0.8            
 [58] plotrix_3.8-1         tiff_0.1-6            zip_2.1.1            
 [61] bitops_1.0-6          rlang_0.4.10          pkgconfig_2.0.3      
 [64] systemfonts_1.0.1     evaluate_0.14         lattice_0.20-41      
 [67] labeling_0.4.2        cowplot_1.1.1         tidyselect_1.1.0     
 [70] magrittr_2.0.1        R6_2.5.0              generics_0.1.0       
 [73] multcomp_1.4-16       DBI_1.1.1             pillar_1.5.0         
 [76] haven_2.3.1           whisker_0.4           foreign_0.8-81       
 [79] withr_2.4.1           rebus_0.1-3           survival_3.2-7       
 [82] abind_1.4-5           rebus.unicode_0.0-2   modelr_0.1.8         
 [85] crayon_1.4.1          car_3.0-10            utf8_1.1.4           
 [88] rmarkdown_2.7         jpeg_0.1-8.1          grid_4.0.4           
 [91] readxl_1.3.1          data.table_1.14.0     git2r_0.28.0         
 [94] reprex_1.0.0          digest_0.6.27         webshot_0.5.2        
 [97] httpuv_1.5.5          munsell_0.5.0         viridisLite_0.3.0    
[100] bslib_0.2.4