Last updated: 2021-04-15

Checks: 6 1

Knit directory: esoph-micro-cancer-workflow/

This reproducible R Markdown analysis was created with workflowr (version 1.6.2). The Checks tab describes the reproducibility checks that were applied when the results were created. The Past versions tab lists the development history.

R Markdown file: uncommitted changes

The R Markdown is untracked by Git. To know which version of the R Markdown file created these results, you’ll want to first commit it to the Git repo. If you’re still working on the analysis, you can ignore this warning. When you’re finished, you can run wflow_publish to commit the R Markdown file and build the HTML.

Environment: empty

Great job! The global environment was empty. Objects defined in the global environment can affect the analysis in your R Markdown file in unknown ways. For reproduciblity it’s best to always run the code in an empty environment.

Seed: set.seed(20200916)

The command set.seed(20200916) was run prior to running the code in the R Markdown file. Setting a seed ensures that any results that rely on randomness, e.g. subsampling or permutations, are reproducible.

Session information: recorded

Great job! Recording the operating system, R version, and package versions is critical for reproducibility.

Cache: none

Nice! There were no cached chunks for this analysis, so you can be confident that you successfully produced the results during this run.

File paths: relative

Great job! Using relative paths to the files within your workflowr project makes it easier to run your code on other machines.

Repository version: b11a4b5

Great! You are using Git for version control. Tracking code development and connecting the code version to the results is critical for reproducibility.

The results in this page were generated with repository version b11a4b5. See the Past versions tab to see a history of the changes made to the R Markdown and HTML files.

Note that you need to be careful to ensure that all relevant files for the analysis have been committed to Git prior to generating the results (you can use wflow_publish or wflow_git_commit). workflowr only checks the R Markdown file, but you know if there are other scripts or data files that it depends on. Below is the status of the Git repository when the results were generated: 


Ignored files:
    Ignored:    .Rhistory
    Ignored:    .Rproj.user/
    Ignored:    data/

Untracked files:
    Untracked:  analysis/picrust-campy.Rmd
    Untracked:  analysis/picrust-fuso.Rmd
    Untracked:  analysis/picrust-prevo.Rmd
    Untracked:  analysis/picrust-strepto.Rmd
    Untracked:  code/results-question-1.Rmd
    Untracked:  code/results-question-2.Rmd
    Untracked:  code/results-question-3.Rmd
    Untracked:  output/picrust_ec_stratefied_campy_data_results.csv
    Untracked:  output/picrust_ec_stratefied_fuso_data_results.csv
    Untracked:  output/picrust_ko_stratefied_campy_data_results.csv
    Untracked:  output/picrust_ko_stratefied_fuso_data_results.csv

Unstaged changes:
    Modified:   analysis/index.Rmd
    Modified:   analysis/picrust-analyses.Rmd
    Deleted:    analysis/results-question-1.Rmd
    Deleted:    analysis/results-question-2.Rmd
    Deleted:    analysis/results-question-3.Rmd

Note that any generated files, e.g. HTML, png, CSS, etc., are not included in this status report because it is ok for generated content to have uncommitted changes.

There are no past versions. Publish this analysis with wflow_publish() to start tracking its development. 

i. Mean relative abundance in Tumors

ii. Standard error of mean in Tumors

iii. Mean relative abundance in Non-tumors

iv. Standard error of mean in Non-tumors

v. GLM differential abundance analysis between Tumor vs Non-tumor (Patient=Fixed effect)
  1. P-value
  2. FDR corrected q-value
vi. GLMM differential abundance analysis between Tumor vs Non-tumor (Patient=Random Effect)
  1.P-value
  2. FDR corrected q-value

Part 1 EC Data

# note: must rename function to func (or something else) because "function" is a reserved name in R and can't be used.

descriptions <- readr::read_tsv("data/PICRUST/ec_pred_metagenome_unstrat_descrip.tsv")[,1:2] %>%
  distinct()

-- Column specification --------------------------------------------------------
cols(
  .default = col_double(),
  `function` = col_character(),
  description = col_character()
)
i Use `spec()` for the full column specifications.
colnames(descriptions) <- c("func", "description")

pi.dat <- readxl::read_xlsx("data/PICRUST-Stratified/EC_prevo.xlsx")
colnames(pi.dat) <- c("func",  colnames(pi.dat)[-c(1)])

# add descriptions to dataframe
pi.dat <- left_join(pi.dat, descriptions, by="func")
pi.dat <- pi.dat[,c(1,161,3:160)]

# aggregate descriptions to get 1 description per row - unique;y defined.
pi.dat <- pi.dat %>%
  group_by(description) %>%
  summarise(across(`1.S37.Jun172016`:`99.D01.S37.Jun232016`,.fns = mean))

# make long format
pi.dat <- pi.dat %>%
  pivot_longer(
    cols=`1.S37.Jun172016`:`99.D01.S37.Jun232016`,
    names_to = "ID",
    values_to = "Abundance"
  )
d <- as.data.frame(dat.16s)
mydata <- full_join(pi.dat, d)
Joining, by = "ID"
Warning in class(x) <- c(setdiff(subclass, tibble_class), tibble_class): Setting
class(x) to multiple strings ("tbl_df", "tbl", ...); result will no longer be an
S4 object
mydata <- mydata %>%
  mutate(
    ID.n = as.numeric(as.factor(ID)),
    description.n = as.numeric(as.factor(description))
  ) %>%
  group_by(description)%>%
  mutate(avgA = mean(Abundance))

Abundance

I needed to change from relative abundance to abundance due to so many individuals having 0 counts for all descriptions.

d <- mydata %>%
  filter(description=="DNA-directed DNA polymerase")

t.test(d$Abundance ~ d$tumor.cat)

    Welch Two Sample t-test

data:  d$Abundance by d$tumor.cat
t = 0.808, df = 156, p-value = 0.42
alternative hypothesis: true difference in means is not equal to 0
95 percent confidence interval:
 -2.575  6.142
sample estimates:
mean in group Non-Tumor     mean in group Tumor 
                 8.7621                  6.9787 
# Run on all descriptions
tb.ra1 <- mydata %>%
  group_by(description) %>%
  summarise(ng = n(),
            Overall.M = mean(Abundance),
            Overall.SE = sd(Abundance)/sqrt(ng))
tb.ra2m <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(M = mean(Abundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = M)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra2se <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(),SE = sd(Abundance)/sqrt(ng)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = SE)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra2var <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(), VAR = var(Abundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = VAR)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra2ng <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n()) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = ng)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra <- left_join(tb.ra1, tb.ra2m)
Joining, by = "description"
tb.ra <- cbind(tb.ra, tb.ra2se[,-1])
tb.ra <- cbind(tb.ra, tb.ra2var[,-1])
tb.ra <- cbind(tb.ra, tb.ra2ng[,-1]) 

colnames(tb.ra) <- c("description", "ng", "Overall Mean", "Overall SE", "Non-Tumor Mean", "Tumor Mean", "Non-Tumor SE", "Tumor SE","Non-Tumor Var", "Tumor Var", "Non-Tumor Ng", "Tumor Ng")
tb.ra <- tb.ra %>%
  arrange(desc(`Overall Mean`))
tb.ra <- tb.ra[, c("description", "Overall Mean", "Overall SE","Tumor Mean","Tumor Var", "Tumor SE","Tumor Ng", "Non-Tumor Mean","Non-Tumor Var", "Non-Tumor SE", "Non-Tumor Ng")]

# compute t-test
tb.ra <- tb.ra %>%
  mutate(
    SEpooled = sqrt(`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`),
    t = (`Tumor Mean` - `Non-Tumor Mean`)/(SEpooled),
    df = ((`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`)**2)/(((`Tumor Var`/`Tumor Ng`)**2)/(`Tumor Ng`-1) + ((`Non-Tumor Var`/`Non-Tumor Ng`)**2)/(`Non-Tumor Ng`-1)),
    p = pt(q = abs(t), df=df, lower.tail = F)*2,
    fdr_p = p.adjust(p, method="fdr")
  )


kable(tb.ra, format="html", digits=5, caption="Stratefied EC Data - Prevotella spp. (genus level only): Average Abundance of Each Description (sorted in descending order)") %>%
  kable_styling(full_width = T) %>%
  scroll_box(width = "100%", height="600px")
Stratefied EC Data - Prevotella spp. (genus level only): Average Abundance of Each Description (sorted in descending order)
description Overall Mean Overall SE Tumor Mean Tumor Var Tumor SE Tumor Ng Non-Tumor Mean Non-Tumor Var Non-Tumor SE Non-Tumor Ng SEpooled t df p fdr_p
NADH:ubiquinone reductase (H(+)-translocating) 8.87320 1.27123 7.69867 168.38125 1.60950 65 9.69410 316.93644 1.84605 93 2.44916 -0.81474 155.700 0.41647 0.57933
DNA helicase 8.70286 1.26020 7.51459 163.32620 1.58515 65 9.53337 312.88664 1.83422 93 2.42427 -0.83274 155.808 0.40627 0.57933
Peptidylprolyl isomerase 8.38237 1.19184 7.34589 152.31948 1.53081 65 9.10679 275.75335 1.72194 93 2.30401 -0.76427 155.375 0.44586 0.57933
23S rRNA (adenine(2085)-N(6))-dimethyltransferase 8.24684 1.49040 8.93846 312.33990 2.19208 65 7.76344 381.07387 2.02425 93 2.98376 0.39381 145.890 0.69430 0.75992
DNA-directed DNA polymerase 8.02844 1.14496 6.97867 136.88722 1.45119 65 8.76214 256.92136 1.66211 93 2.20648 -0.80829 155.680 0.42016 0.57933
2-oxoglutarate synthase 5.19332 0.75914 4.48637 59.69762 0.95834 65 5.68743 113.25740 1.10355 93 1.46159 -0.82175 155.751 0.41247 0.57933
Glycerol-3-phosphate dehydrogenase 4.02373 0.65081 3.49615 31.16307 0.69241 65 4.39247 92.19076 0.99564 93 1.21274 -0.73909 151.551 0.46100 0.57933
DNA topoisomerase 3.73034 0.59433 3.10525 34.46261 0.72814 65 4.16722 70.79682 0.87250 93 1.13642 -0.93449 156.000 0.35150 0.57933
2-oxoacid oxidoreductase (ferredoxin) 3.41868 0.50521 2.94663 26.36358 0.63686 65 3.74861 50.21162 0.73479 93 0.97237 -0.82477 155.774 0.41077 0.57933
Methylaspartate mutase 3.33755 0.92571 2.91282 77.93846 1.09501 65 3.63441 176.62334 1.37811 93 1.76018 -0.40995 155.652 0.68241 0.75116
Site-specific DNA-methyltransferase (adenine-specific) 3.29688 0.48730 2.89114 26.44815 0.63788 65 3.58046 45.42989 0.69892 93 0.94625 -0.72848 154.752 0.46742 0.58202
Type I site-specific deoxyribonuclease 3.17729 0.46624 2.74544 20.66831 0.56389 65 3.47911 44.00984 0.68791 93 0.88949 -0.82482 155.955 0.41073 0.57933
Beta-galactosidase 3.01906 0.43442 2.59337 16.24369 0.49990 65 3.31658 39.36714 0.65062 93 0.82049 -0.88144 155.023 0.37945 0.57933
5’ to 3’ exodeoxyribonuclease (nucleoside 3’-phosphate-forming) 2.78481 1.14192 1.63077 36.67404 0.75114 65 3.59140 324.48340 1.86790 93 2.01328 -0.97385 119.662 0.33210 0.57933
Formyltetrahydrofolate deformylase 2.78481 1.14192 1.63077 36.67404 0.75114 65 3.59140 324.48340 1.86790 93 2.01328 -0.97385 119.662 0.33210 0.57933
Alpha-L-fucosidase 2.74904 0.39463 2.36477 14.25551 0.46831 65 3.01761 31.89585 0.58563 93 0.74985 -0.87062 155.737 0.38530 0.57933
DNA-directed RNA polymerase 2.70495 0.39129 2.35257 16.76654 0.50788 65 2.95124 29.46928 0.56292 93 0.75817 -0.78962 155.051 0.43095 0.57933
23S rRNA pseudouridine(1911/1915/1917) synthase 2.66196 0.38137 2.30960 15.15431 0.48285 65 2.90823 28.52428 0.55382 93 0.73475 -0.81474 155.700 0.41647 0.57933
C-terminal processing peptidase 2.66196 0.38137 2.30960 15.15431 0.48285 65 2.90823 28.52428 0.55382 93 0.73475 -0.81474 155.700 0.41647 0.57933
Beta-N-acetylhexosaminidase 2.54759 0.33420 2.23600 10.03300 0.39288 65 2.76538 23.01861 0.49751 93 0.63393 -0.83507 155.560 0.40496 0.57933
Long-chain-fatty-acid–CoA ligase 2.48114 0.36259 2.12976 12.59593 0.44021 65 2.72673 26.53775 0.53418 93 0.69220 -0.86243 155.978 0.38977 0.57933
Galactoside O-acetyltransferase 2.44304 0.43807 2.35385 23.69096 0.60372 65 2.50538 35.25356 0.61569 93 0.86229 -0.17573 151.987 0.86074 0.91444
[Formate-C-acetyltransferase]-activating enzyme 2.36772 0.34270 2.08987 12.52266 0.43893 65 2.56192 22.86272 0.49582 93 0.66219 -0.71287 155.456 0.47700 0.58389
Phosphomethylpyrimidine synthase 2.21751 0.41729 2.23641 21.65211 0.57716 65 2.20430 31.88716 0.58555 93 0.82218 0.03905 151.729 0.96890 0.97226
Acid phosphatase 2.12922 0.31788 2.03846 10.04537 0.39312 65 2.19265 20.24728 0.46660 93 0.61013 -0.25272 155.985 0.80082 0.86239
Glutathione peroxidase 2.08575 0.30445 1.84212 9.82200 0.38873 65 2.25603 18.08841 0.44102 93 0.58788 -0.70406 155.532 0.48245 0.58808
All-trans-retinol 13,14-reductase 2.06962 0.51497 1.30000 7.26781 0.33438 65 2.60753 65.73679 0.84074 93 0.90480 -1.44510 119.123 0.15105 0.57933
Ribonucleoside-diphosphate reductase 2.05690 0.29130 1.86589 10.08857 0.39397 65 2.19040 15.81714 0.41240 93 0.57034 -0.56898 153.168 0.57021 0.66830
Undecaprenyl-diphosphate phosphatase 2.00941 0.29161 1.69501 8.38834 0.35924 65 2.22914 16.97370 0.42722 93 0.55818 -0.95691 155.990 0.34009 0.57933
Cyclic pyranopterin phosphate synthase 1.95570 0.59054 1.80000 15.53750 0.48892 65 2.06452 83.19144 0.94580 93 1.06469 -0.24844 133.985 0.80417 0.86239
Protein-L-isoaspartate(D-aspartate) O-methyltransferase 1.95570 0.59054 1.80000 15.53750 0.48892 65 2.06452 83.19144 0.94580 93 1.06469 -0.24844 133.985 0.80417 0.86239
UDP-glucuronate decarboxylase 1.95570 0.59054 1.80000 15.53750 0.48892 65 2.06452 83.19144 0.94580 93 1.06469 -0.24844 133.985 0.80417 0.86239
Succinate–CoA ligase (ADP-forming) 1.93639 0.30827 1.74308 11.18452 0.41481 65 2.07151 17.79801 0.43747 93 0.60286 -0.54478 153.468 0.58670 0.67955
Alpha-amylase 1.92010 0.27559 1.64690 7.13167 0.33124 65 2.11105 15.42784 0.40730 93 0.52498 -0.88413 155.905 0.37799 0.57933
Chondroitin-sulfate-ABC endolyase 1.89557 0.58745 1.20769 10.04603 0.39313 65 2.37634 85.49270 0.95879 93 1.03626 -1.12776 120.634 0.26166 0.57933
Chondroitin-sulfate-ABC exolyase 1.89557 0.58745 1.20769 10.04603 0.39313 65 2.37634 85.49270 0.95879 93 1.03626 -1.12776 120.634 0.26166 0.57933
Fructuronate reductase 1.89557 0.58745 1.20769 10.04603 0.39313 65 2.37634 85.49270 0.95879 93 1.03626 -1.12776 120.634 0.26166 0.57933
Phosphoglycerate mutase (2,3-diphosphoglycerate-independent) 1.86338 0.28190 1.55473 7.36391 0.33659 65 2.07911 16.19044 0.41724 93 0.53608 -0.97818 155.834 0.32950 0.57933
Thiamine-phosphate diphosphorylase 1.84301 0.30387 1.77550 11.57318 0.42196 65 1.89020 16.84047 0.42554 93 0.59927 -0.19139 151.422 0.84848 0.90307
DNA (cytosine-5-)-methyltransferase 1.83761 0.27317 1.58082 6.34957 0.31255 65 2.01709 15.62402 0.40988 93 0.51545 -0.84638 154.840 0.39865 0.57933
Beta-glucosidase 1.83754 0.37510 1.42643 10.79776 0.40758 65 2.12488 30.22281 0.57007 93 0.70078 -0.99666 152.728 0.32050 0.57933
S-adenosylmethionine:tRNA ribosyltransferase-isomerase 1.81763 0.26441 1.58271 7.84342 0.34737 65 1.98183 13.32825 0.37857 93 0.51379 -0.77682 154.598 0.43845 0.57933
Peroxiredoxin 1.79577 0.25581 1.55236 6.81598 0.32382 65 1.96589 12.83220 0.37146 93 0.49279 -0.83916 155.701 0.40267 0.57933
Carbamoyl-phosphate synthase (glutamine-hydrolyzing) 1.79498 0.25900 1.55629 7.00384 0.32825 65 1.96181 13.14606 0.37597 93 0.49911 -0.81250 155.680 0.41775 0.57933
GTP diphosphokinase 1.79472 0.25899 1.55618 7.00416 0.32826 65 1.96144 13.14542 0.37596 93 0.49910 -0.81197 155.680 0.41805 0.57933
Pyridoxal 5’-phosphate synthase (glutamine hydrolyzing) 1.79417 0.26143 1.56835 7.09991 0.33050 65 1.95200 13.42770 0.37998 93 0.50360 -0.76181 155.731 0.44733 0.57933
H(+)-transporting two-sector ATPase 1.78402 0.25443 1.54133 6.73809 0.32197 65 1.95365 12.69662 0.36949 93 0.49009 -0.84133 155.707 0.40145 0.57933
Mannose-1-phosphate guanylyltransferase 1.77468 0.25424 1.53984 6.73493 0.32189 65 1.93882 12.67746 0.36921 93 0.48983 -0.81453 155.700 0.41658 0.57933
Acyl-[acyl-carrier-protein]–UDP-N-acetylglucosamine O-acyltransferase 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.57933
Dipeptidyl-peptidase IV 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.57933
DNA topoisomerase (ATP-hydrolyzing) 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.57933
Exodeoxyribonuclease VII 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.57933
Fumarate reductase (quinol) 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.57933
IMP cyclohydrolase 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.57933
Phenylalanine–tRNA ligase 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.57933
Phosphoribosylaminoimidazolecarboxamide formyltransferase 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.57933
Ribonuclease H 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.57933
Succinate dehydrogenase (quinone) 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.57933
tRNA dimethylallyltransferase 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.57933
Uridine kinase 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.57933
XTP/dITP diphosphatase 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.57933
Xaa-Pro aminopeptidase 1.77289 0.25428 1.53602 6.74360 0.32210 65 1.93845 12.67577 0.36919 93 0.48995 -0.82138 155.690 0.41269 0.57933
Peptidyl-dipeptidase Dcp 1.76264 0.26389 1.52647 7.76356 0.34560 65 1.92770 13.30841 0.37829 93 0.51239 -0.78305 154.723 0.43479 0.57933
5’-nucleotidase 1.75347 0.25311 1.52700 6.66960 0.32033 65 1.91175 12.57260 0.36768 93 0.48765 -0.78900 155.710 0.43131 0.57933
Sialate O-acetylesterase 1.74466 0.26559 1.46302 5.38439 0.28781 65 1.94151 15.17863 0.40399 93 0.49603 -0.96464 152.585 0.33625 0.57933
Glycine dehydrogenase (aminomethyl-transferring) 1.74106 0.27045 1.55050 8.64640 0.36472 65 1.87424 13.66341 0.38330 93 0.52909 -0.61187 153.329 0.54153 0.63989
Bleomycin hydrolase 1.73339 0.24859 1.51056 6.42249 0.31434 65 1.88914 12.13470 0.36122 93 0.47884 -0.79062 155.725 0.43037 0.57933
Aldose 1-epimerase 1.70764 0.25264 1.46971 6.59844 0.31861 65 1.87393 12.55117 0.36737 93 0.48629 -0.83125 155.767 0.40710 0.57933
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1.69935 0.25200 1.47342 6.59059 0.31842 65 1.85725 12.47603 0.36627 93 0.48533 -0.79086 155.737 0.43023 0.57933
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase 1.68931 0.24805 1.45698 6.34169 0.31235 65 1.85169 12.11350 0.36091 93 0.47730 -0.82696 155.791 0.40952 0.57933
Dephospho-CoA kinase 1.68603 0.25086 1.46493 6.48323 0.31582 65 1.84056 12.39950 0.36514 93 0.48277 -0.77807 155.798 0.43771 0.57933
Choline-phosphate cytidylyltransferase 1.66878 0.46286 1.45641 19.48462 0.54751 65 1.81720 44.15584 0.68905 93 0.88009 -0.40995 155.652 0.68241 0.75116
Methylaspartate ammonia-lyase 1.66878 0.46286 1.45641 19.48462 0.54751 65 1.81720 44.15584 0.68905 93 0.88009 -0.40995 155.652 0.68241 0.75116
Tryptophanase 1.66878 0.46286 1.45641 19.48462 0.54751 65 1.81720 44.15584 0.68905 93 0.88009 -0.40995 155.652 0.68241 0.75116
Coproporphyrinogen dehydrogenase 1.66377 0.23703 1.44637 5.81089 0.29900 65 1.81572 11.04920 0.34469 93 0.45630 -0.80946 155.765 0.41948 0.57933
Maltose alpha-D-glucosyltransferase 1.65506 0.61136 1.09231 14.98353 0.48012 65 2.04839 89.97318 0.98359 93 1.09452 -0.87352 130.421 0.38399 0.57933
Glycerol kinase 1.64376 0.27456 1.57143 7.20663 0.33297 65 1.69432 15.30550 0.40568 93 0.52483 -0.23415 155.961 0.81518 0.87083
Phosphoglycolate phosphatase 1.63605 0.22237 1.42621 4.85721 0.27336 65 1.78272 9.90094 0.32628 93 0.42566 -0.83755 155.997 0.40356 0.57933
2-dehydropantoate 2-reductase 1.61850 0.25853 1.41368 5.91609 0.30169 65 1.76165 13.85538 0.38598 93 0.48990 -0.71030 155.382 0.47858 0.58460
Fructokinase 1.59684 0.23344 1.37824 5.35937 0.28714 65 1.74962 10.90726 0.34247 93 0.44692 -0.83097 155.996 0.40726 0.57933
Non-specific serine/threonine protein kinase 1.59396 0.24475 1.55308 8.62888 0.36435 65 1.62254 10.14689 0.33031 93 0.49179 -0.14124 144.521 0.88788 0.94070
Aspartate transaminase 1.59236 0.22338 1.37716 4.39429 0.26001 65 1.74276 10.34194 0.33347 93 0.42286 -0.86460 155.335 0.38859 0.57933
Methionyl aminopeptidase 1.59022 0.22308 1.38536 4.92936 0.27538 65 1.73341 9.93905 0.32691 93 0.42744 -0.81426 155.985 0.41674 0.57933
Glucosamine-6-phosphate deaminase 1.57069 0.22173 1.36710 4.29694 0.25711 65 1.71299 10.21754 0.33146 93 0.41949 -0.82454 155.232 0.41090 0.57933
Alpha-N-acetylglucosaminidase 1.56804 0.57661 0.87308 9.23266 0.37688 65 2.05376 82.64518 0.94269 93 1.01523 -1.16297 119.376 0.24716 0.57933
Methylmalonyl-CoA mutase 1.56044 0.23473 1.34000 4.60666 0.26622 65 1.71452 11.59286 0.35306 93 0.44218 -0.84697 154.541 0.39832 0.57933
Cobaltochelatase 1.56013 0.31434 1.25897 7.86721 0.34790 65 1.77061 21.05973 0.47587 93 0.58948 -0.86795 153.565 0.38678 0.57933
Aspartate kinase 1.55792 0.22318 1.33549 4.84715 0.27308 65 1.71339 9.99837 0.32789 93 0.42671 -0.88560 156.000 0.37720 0.57933
Mannan endo-1,4-beta-mannosidase 1.49324 0.25655 1.21474 4.20653 0.25439 65 1.68789 14.72714 0.39794 93 0.47231 -1.00179 147.217 0.31809 0.57933
8-oxo-dGTP diphosphatase 1.48703 0.23488 1.37615 6.41118 0.31406 65 1.56452 10.40014 0.33441 93 0.45876 -0.41059 153.832 0.68195 0.75116
Leucine–tRNA ligase 1.44723 0.20945 1.26218 4.66661 0.26794 65 1.57657 8.54070 0.30304 93 0.40451 -0.77721 155.478 0.43821 0.57933
Uracil-DNA glycosylase 1.42115 0.21151 1.25422 4.39841 0.26013 65 1.53782 8.96938 0.31056 93 0.40511 -0.70007 155.997 0.48493 0.58986
Glucose-1-phosphatase 1.41667 0.21186 1.35726 4.45679 0.26185 65 1.45818 8.99823 0.31105 93 0.40660 -0.24820 155.987 0.80430 0.86239
Hydroxymethylpyrimidine kinase 1.40152 0.21274 1.29254 5.40085 0.28825 65 1.47770 8.43109 0.30109 93 0.41683 -0.44422 153.077 0.65751 0.73071
Phosphomethylpyrimidine kinase 1.40152 0.21274 1.29254 5.40085 0.28825 65 1.47770 8.43109 0.30109 93 0.41683 -0.44422 153.077 0.65751 0.73071
Alpha-glucuronidase 1.39304 0.57095 0.81692 9.16612 0.37552 65 1.79570 81.12085 0.93395 93 1.00662 -0.97234 119.656 0.33284 0.57933
Beta-ketoacyl-[acyl-carrier-protein] synthase I 1.38633 0.32063 0.84215 2.57519 0.19904 65 1.76667 25.57225 0.52438 93 0.56088 -1.64832 116.932 0.10197 0.57933
Glutamate–ammonia ligase 1.38595 0.19733 1.22302 4.19249 0.25397 65 1.49981 7.55094 0.28494 93 0.38170 -0.72516 155.324 0.46945 0.58303
2-dehydro-3-deoxygluconokinase 1.38101 0.38355 0.94593 8.18439 0.35484 65 1.68510 33.74515 0.60237 93 0.69912 -1.05728 142.297 0.29217 0.57933
Acetolactate synthase 1.37107 0.37877 0.95912 8.19332 0.35504 65 1.65899 32.77952 0.59369 93 0.69175 -1.01173 143.235 0.31337 0.57933
Serine O-acetyltransferase 1.36414 0.19280 1.24018 3.82836 0.24269 65 1.45079 7.34149 0.28096 93 0.37127 -0.56727 155.813 0.57135 0.66830
Alpha-galactosidase 1.35490 0.18980 1.22355 3.46868 0.23101 65 1.44670 7.27929 0.27977 93 0.36282 -0.61507 155.985 0.53940 0.63989
Glutamate dehydrogenase (NADP(+)) 1.35029 0.19046 1.22951 4.15986 0.25298 65 1.43472 6.86956 0.27178 93 0.37130 -0.55268 154.145 0.58128 0.67719
UDP-glucuronate 4-epimerase 1.34494 0.37843 1.30000 13.55312 0.45663 65 1.37634 29.18291 0.56017 93 0.72271 -0.10564 155.921 0.91601 0.94070
Arylsulfatase 1.33931 0.22182 1.23761 4.97468 0.27665 65 1.41039 9.79395 0.32452 93 0.42643 -0.40519 155.927 0.68589 0.75292
Alpha-glucosidase 1.32077 0.19689 1.23077 3.89749 0.24487 65 1.38368 7.73111 0.28832 93 0.37827 -0.40422 155.950 0.68660 0.75292
Glycerol-3-phosphate cytidylyltransferase 1.27848 0.34367 1.55385 17.46971 0.51843 65 1.08602 19.60122 0.45909 93 0.69248 0.67558 142.692 0.50040 0.59952
Pectinesterase 1.26456 0.39162 0.80718 4.46182 0.26200 65 1.58423 37.99675 0.63919 93 0.69080 -1.12485 120.617 0.26289 0.57933
5-dehydro-4-deoxy-D-glucuronate isomerase 1.26414 0.39163 0.80615 4.46329 0.26204 65 1.58423 37.99675 0.63919 93 0.69082 -1.12631 120.625 0.26227 0.57933
Altronate dehydratase 1.26414 0.39163 0.80615 4.46329 0.26204 65 1.58423 37.99675 0.63919 93 0.69082 -1.12631 120.625 0.26227 0.57933
Tagaturonate reductase 1.26414 0.39163 0.80615 4.46329 0.26204 65 1.58423 37.99675 0.63919 93 0.69082 -1.12631 120.625 0.26227 0.57933
N-acetylneuraminate lyase 1.24747 0.17966 1.09949 2.55363 0.19821 65 1.35090 6.90057 0.27240 93 0.33688 -0.74629 153.397 0.45663 0.57933
Gingipain R 1.24684 0.64160 1.24615 84.15721 1.13786 65 1.24731 52.44904 0.75098 93 1.36334 -0.00085 116.519 0.99932 0.99932
Fumarate hydratase 1.23258 0.20541 1.07119 4.53949 0.26427 65 1.34538 8.18734 0.29671 93 0.39733 -0.69007 155.338 0.49118 0.59125
O-acetylhomoserine aminocarboxypropyltransferase 1.22934 0.18238 1.08240 3.28065 0.22466 65 1.33204 6.66094 0.26762 93 0.34942 -0.71445 155.994 0.47602 0.58389
Sulfate adenylyltransferase 1.22785 0.61341 0.73846 24.82115 0.61795 65 1.56989 83.89995 0.94982 93 1.13314 -0.73374 148.198 0.46427 0.57933
Methionine synthase 1.21907 0.18450 1.07449 3.26570 0.22415 65 1.32012 6.88104 0.27201 93 0.35246 -0.69689 155.978 0.48691 0.59000
Hyaluronoglucosaminidase 1.20863 0.18683 1.03736 2.53613 0.19753 65 1.32834 7.61253 0.28610 93 0.34767 -0.83694 151.219 0.40394 0.57933
Asparaginase 1.20334 0.19490 1.02451 3.97096 0.24717 65 1.32833 7.44163 0.28287 93 0.37565 -0.80879 155.669 0.41987 0.57933
4-O-beta-D-mannosyl-D-glucose phosphorylase 1.19937 0.33040 0.81538 6.28179 0.31087 65 1.46774 24.88754 0.51731 93 0.60353 -1.08090 143.538 0.28155 0.57933
D-lactate dehydrogenase 1.19488 0.16852 1.13333 2.77166 0.20650 65 1.23790 5.72496 0.24811 93 0.32280 -0.32395 155.999 0.74641 0.80931
3-oxoacyl-[acyl-carrier-protein] reductase 1.17501 0.17336 0.94743 2.41854 0.19289 65 1.33407 6.35848 0.26148 93 0.32493 -1.18994 153.873 0.23590 0.57933
Glycerate 3-kinase 1.17495 0.18401 1.03538 3.52709 0.23294 65 1.27250 6.65223 0.26745 93 0.35467 -0.66854 155.713 0.50478 0.60261
DNA-3-methyladenine glycosylase I 1.17245 0.18913 1.01953 3.52469 0.23286 65 1.27934 7.16494 0.27757 93 0.36231 -0.71708 155.995 0.47440 0.58318
DNA-(apurinic or apyrimidinic site) lyase 1.17169 0.16825 1.07809 3.36481 0.22752 65 1.23712 5.28178 0.23831 93 0.32948 -0.48265 153.192 0.63003 0.70833
Exodeoxyribonuclease III 1.17169 0.16825 1.07809 3.36481 0.22752 65 1.23712 5.28178 0.23831 93 0.32948 -0.48265 153.192 0.63003 0.70833
Signal peptidase I 1.15362 0.16620 1.00605 2.79378 0.20732 65 1.25677 5.47819 0.24270 93 0.31920 -0.78547 155.913 0.43337 0.57933
Alkaline phosphatase 1.14684 0.25842 0.88923 3.79879 0.24175 65 1.32688 15.28416 0.40540 93 0.47200 -0.92722 143.060 0.35538 0.57933
Alanine dehydrogenase 1.14557 0.30192 0.74615 3.00877 0.21515 65 1.42473 22.29454 0.48962 93 0.53480 -1.26883 124.297 0.20687 0.57933
Threonine ammonia-lyase 1.13063 0.25296 0.88985 3.75645 0.24040 65 1.29892 14.57011 0.39581 93 0.46310 -0.88335 144.189 0.37852 0.57933
3-hydroxyacyl-[acyl-carrier-protein] dehydratase 1.12634 0.16778 0.91507 2.21757 0.18471 65 1.27401 5.99412 0.25388 93 0.31396 -1.14328 153.392 0.25470 0.57933
Carbonate dehydratase 1.12238 0.18217 1.01287 3.32961 0.22633 65 1.19892 6.61767 0.26675 93 0.34983 -0.53185 155.956 0.59559 0.68286
Prolyl oligopeptidase 1.09605 0.17348 0.96352 3.09898 0.21835 65 1.18868 5.93799 0.25268 93 0.33396 -0.67425 155.809 0.50115 0.59952
Thymidylate synthase (FAD) 1.09367 0.29995 0.72385 3.00696 0.21508 65 1.35215 22.00304 0.48641 93 0.53184 -1.18138 124.645 0.23970 0.57933
Cob(I)yrinic acid a,c-diamide adenosyltransferase 1.09107 0.17600 0.93105 3.31354 0.22578 65 1.20291 6.01597 0.25434 93 0.34010 -0.79934 155.403 0.42531 0.57933
Glycine C-acetyltransferase 1.08936 0.19753 0.88974 2.30356 0.18825 65 1.22888 8.86981 0.30883 93 0.36168 -0.93766 144.411 0.34998 0.57933
Indole-3-glycerol-phosphate synthase 1.08875 0.22804 0.85846 5.14544 0.28135 65 1.24970 10.37860 0.33406 93 0.43676 -0.89578 155.986 0.37175 0.57933
Serine-type D-Ala-D-Ala carboxypeptidase 1.08466 0.16430 0.90631 2.54642 0.19793 65 1.20931 5.46909 0.24250 93 0.31302 -0.96796 155.930 0.33456 0.57933
Glucokinase 1.08069 0.15300 0.91523 2.08960 0.17930 65 1.19633 4.82502 0.22778 93 0.28988 -0.96973 155.508 0.33369 0.57933
Superoxide reductase 1.07949 0.16837 0.97557 3.03351 0.21603 65 1.15212 5.52058 0.24364 93 0.32562 -0.54220 155.426 0.58846 0.67955
Inositol-3-phosphate synthase 1.06705 0.17302 0.97795 3.53452 0.23319 65 1.12933 5.60300 0.24545 93 0.33856 -0.44713 153.392 0.65541 0.73071
Phosphoserine phosphatase 1.06604 0.16400 0.92092 3.01917 0.21552 65 1.16747 5.12606 0.23477 93 0.31870 -0.77362 154.585 0.44034 0.57933
Formimidoyltetrahydrofolate cyclodeaminase 1.05802 0.17069 0.95855 3.47823 0.23132 65 1.12754 5.42424 0.24151 93 0.33442 -0.50533 153.056 0.61405 0.69713
Glutamate formimidoyltransferase 1.05802 0.17069 0.95855 3.47823 0.23132 65 1.12754 5.42424 0.24151 93 0.33442 -0.50533 153.056 0.61405 0.69713
Histidine ammonia-lyase 1.05802 0.17069 0.95855 3.47823 0.23132 65 1.12754 5.42424 0.24151 93 0.33442 -0.50533 153.056 0.61405 0.69713
Imidazolonepropionase 1.05802 0.17069 0.95855 3.47823 0.23132 65 1.12754 5.42424 0.24151 93 0.33442 -0.50533 153.056 0.61405 0.69713
Urocanate hydratase 1.05802 0.17069 0.95855 3.47823 0.23132 65 1.12754 5.42424 0.24151 93 0.33442 -0.50533 153.056 0.61405 0.69713
Nicotinamidase 1.05680 0.16226 0.99676 3.08655 0.21791 65 1.09875 4.94772 0.23065 93 0.31731 -0.32143 153.610 0.74832 0.80986
2’,3’-cyclic-nucleotide 2’-phosphodiesterase 1.03813 0.15560 0.86960 2.12907 0.18098 65 1.15591 5.01277 0.23217 93 0.29437 -0.97261 155.332 0.33226 0.57933
3’-nucleotidase 1.03813 0.15560 0.86960 2.12907 0.18098 65 1.15591 5.01277 0.23217 93 0.29437 -0.97261 155.332 0.33226 0.57933
Beta-ketoacyl-[acyl-carrier-protein] synthase III 1.03420 0.16752 0.90143 3.04246 0.21635 65 1.12699 5.42925 0.24162 93 0.32432 -0.69548 155.226 0.48780 0.59000
Glutamate synthase (NADH) 1.03284 0.15847 0.84330 2.11659 0.18045 65 1.16532 5.25552 0.23772 93 0.29845 -1.07898 154.723 0.28227 0.57933
Glutamate synthase (NADPH) 1.03284 0.15847 0.84330 2.11659 0.18045 65 1.16532 5.25552 0.23772 93 0.29845 -1.07898 154.723 0.28227 0.57933
Aspartate ammonia-lyase 1.02337 0.15977 0.87191 2.22413 0.18498 65 1.12923 5.30824 0.23891 93 0.30215 -0.85164 155.194 0.39573 0.57933
Butyrate kinase 1.02182 0.16349 0.93441 3.15985 0.22048 65 1.08291 4.99974 0.23186 93 0.31996 -0.46411 153.355 0.64323 0.71897
Phosphate butyryltransferase 1.02182 0.16349 0.93441 3.15985 0.22048 65 1.08291 4.99974 0.23186 93 0.31996 -0.46411 153.355 0.64323 0.71897
23S rRNA pseudouridine(746) synthase 1.02173 0.16584 0.89071 2.97830 0.21406 65 1.11330 5.32313 0.23924 93 0.32103 -0.69337 155.243 0.48912 0.59000
tRNA pseudouridine(32) synthase 1.02173 0.16584 0.89071 2.97830 0.21406 65 1.11330 5.32313 0.23924 93 0.32103 -0.69337 155.243 0.48912 0.59000
Pyridoxal kinase 1.02128 0.15197 0.91167 2.41098 0.19259 65 1.09789 4.53521 0.22083 93 0.29301 -0.63556 155.695 0.52600 0.62665
UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) 1.01984 0.14519 0.85273 1.82545 0.16758 65 1.13663 4.38041 0.21703 93 0.27420 -1.03538 155.135 0.30210 0.57933
Histidinol-phosphate transaminase 1.01905 0.14116 0.92515 1.83094 0.16783 65 1.08468 4.08823 0.20967 93 0.26857 -0.59398 155.750 0.55339 0.65257
1-deoxy-D-xylulose-5-phosphate synthase 1.00849 0.14842 0.88589 2.52045 0.19692 65 1.09418 4.16802 0.21170 93 0.28913 -0.72041 154.169 0.47236 0.58318
L-rhamnose isomerase 0.99831 0.38400 0.57538 4.10133 0.25119 65 1.29391 36.69046 0.62811 93 0.67647 -1.06216 119.391 0.29031 0.57933
Rhamnulokinase 0.99831 0.38400 0.57538 4.10133 0.25119 65 1.29391 36.69046 0.62811 93 0.67647 -1.06216 119.391 0.29031 0.57933
Rhamnulose-1-phosphate aldolase 0.99831 0.38400 0.57538 4.10133 0.25119 65 1.29391 36.69046 0.62811 93 0.67647 -1.06216 119.391 0.29031 0.57933
N-acetylmuramoyl-L-alanine amidase 0.99535 0.15085 0.83353 2.30607 0.18836 65 1.10845 4.50038 0.21998 93 0.28960 -0.94932 155.895 0.34392 0.57933
Protoporphyrinogen oxidase 0.99084 0.14020 0.85900 2.02211 0.17638 65 1.08298 3.87268 0.20406 93 0.26972 -0.83043 155.806 0.40757 0.57933
D-Ala-D-Ala dipeptidase 0.99079 0.13819 0.87704 2.03436 0.17691 65 1.07029 3.71838 0.19996 93 0.26698 -0.72384 155.466 0.47025 0.58303
Acetate–CoA ligase 0.98474 0.14425 0.86939 1.81708 0.16720 65 1.06537 4.33031 0.21578 93 0.27298 -0.71790 155.209 0.47390 0.58318
4-carboxymuconolactone decarboxylase 0.97848 0.29526 0.90154 3.88172 0.24437 65 1.03226 20.79786 0.47290 93 0.53231 -0.24557 133.963 0.80639 0.86303
Nitrite reductase (cytochrome; ammonia-forming) 0.97651 0.14137 0.85444 2.10075 0.17978 65 1.06183 3.90918 0.20502 93 0.27268 -0.76057 155.617 0.44807 0.57933
N-acylglucosamine 2-epimerase 0.96313 0.13569 0.83077 1.43388 0.14853 65 1.05565 3.94579 0.20598 93 0.25394 -0.88553 153.059 0.37726 0.57933
L-arabinose isomerase 0.96234 0.29423 0.61615 2.50509 0.19632 65 1.20430 21.45645 0.48033 93 0.51890 -1.13346 120.471 0.25927 0.57933
L-ribulose-5-phosphate 4-epimerase 0.96234 0.29423 0.61615 2.50509 0.19632 65 1.20430 21.45645 0.48033 93 0.51890 -1.13346 120.471 0.25927 0.57933
Levanase 0.95660 0.14949 0.83417 1.91419 0.17161 65 1.04216 4.67583 0.22423 93 0.28236 -0.73662 154.930 0.46247 0.57933
Type II site-specific deoxyribonuclease 0.95640 0.21683 0.77094 1.69015 0.16125 65 1.08602 11.46005 0.35104 93 0.38630 -0.81564 126.806 0.41624 0.57933
Triose-phosphate isomerase 0.95567 0.14137 0.82408 2.22079 0.18484 65 1.04765 3.82301 0.20275 93 0.27436 -0.81484 154.782 0.41641 0.57933
Cu(2+)-exporting ATPase 0.95476 0.13169 0.83194 1.80421 0.16660 65 1.04060 3.40276 0.19128 93 0.25366 -0.82260 155.713 0.41199 0.57933
Formate C-acetyltransferase 0.95416 0.13648 0.83621 1.95387 0.17338 65 1.03660 3.64631 0.19801 93 0.26319 -0.76139 155.638 0.44758 0.57933
Methylenetetrahydrofolate reductase (NAD(P)H) 0.95074 0.14143 0.80742 1.69554 0.16151 65 1.05092 4.18928 0.21224 93 0.26670 -0.91298 154.787 0.36267 0.57933
Maltose O-acetyltransferase 0.95002 0.15103 0.82438 2.14875 0.18182 65 1.03784 4.63628 0.22328 93 0.28794 -0.74134 155.914 0.45960 0.57933
Thymidylate synthase 0.94975 0.14176 0.85538 2.65241 0.20201 65 1.01570 3.56296 0.19573 93 0.28128 -0.56995 149.138 0.56957 0.66830
Thiamine diphosphokinase 0.94759 0.14099 0.83917 2.06207 0.17811 65 1.02337 3.91100 0.20507 93 0.27162 -0.67813 155.749 0.49869 0.59905
Cystathionine beta-lyase 0.93790 0.14370 0.79458 2.27348 0.18702 65 1.03806 3.96174 0.20640 93 0.27852 -0.87418 154.944 0.38337 0.57933
Hydroxylamine reductase 0.93453 0.13627 0.82348 1.94746 0.17309 65 1.01215 3.63721 0.19776 93 0.26281 -0.71789 155.644 0.47390 0.58318
Cadmium-exporting ATPase 0.93141 0.12843 0.82345 1.75378 0.16426 65 1.00686 3.21315 0.18588 93 0.24805 -0.73940 155.487 0.46078 0.57933
Dihydrofolate reductase 0.93141 0.12843 0.82345 1.75378 0.16426 65 1.00686 3.21315 0.18588 93 0.24805 -0.73940 155.487 0.46078 0.57933
GTP cyclohydrolase I 0.93141 0.12843 0.82345 1.75378 0.16426 65 1.00686 3.21315 0.18588 93 0.24805 -0.73940 155.487 0.46078 0.57933
Zinc-exporting ATPase 0.93141 0.12843 0.82345 1.75378 0.16426 65 1.00686 3.21315 0.18588 93 0.24805 -0.73940 155.487 0.46078 0.57933
Dihydroorotase 0.93031 0.13799 0.81284 2.28793 0.18761 65 1.01242 3.52594 0.19471 93 0.27039 -0.73812 152.800 0.46157 0.57933
Endopeptidase La 0.93031 0.13799 0.81284 2.28793 0.18761 65 1.01242 3.52594 0.19471 93 0.27039 -0.73812 152.800 0.46157 0.57933
Isoleucine–tRNA ligase 0.93031 0.13799 0.81284 2.28793 0.18761 65 1.01242 3.52594 0.19471 93 0.27039 -0.73812 152.800 0.46157 0.57933
Phosphoribosylformylglycinamidine synthase 0.93031 0.13799 0.81284 2.28793 0.18761 65 1.01242 3.52594 0.19471 93 0.27039 -0.73812 152.800 0.46157 0.57933
Transketolase 0.92748 0.13732 0.80276 1.98606 0.17480 65 1.01465 3.68428 0.19904 93 0.26490 -0.79988 155.592 0.42500 0.57933
Aspartate–ammonia ligase 0.92260 0.13172 0.80930 1.52721 0.15328 65 1.00179 3.60065 0.19677 93 0.24942 -0.77173 155.318 0.44145 0.57933
Inorganic diphosphatase 0.92032 0.14160 0.79362 1.73841 0.16354 65 1.00887 4.17766 0.21195 93 0.26770 -0.80408 155.119 0.42258 0.57933
1,4-beta-mannosyl-N-acetylglucosamine phosphorylase 0.91968 0.12914 0.79634 1.29454 0.14112 65 1.00589 3.57808 0.19615 93 0.24164 -0.86720 152.975 0.38719 0.57933
Beta-1,4-mannooligosaccharide phosphorylase 0.91968 0.12914 0.79634 1.29454 0.14112 65 1.00589 3.57808 0.19615 93 0.24164 -0.86720 152.975 0.38719 0.57933
Exo-alpha-sialidase 0.91968 0.12914 0.79634 1.29454 0.14112 65 1.00589 3.57808 0.19615 93 0.24164 -0.86720 152.975 0.38719 0.57933
L-aspartate oxidase 0.91959 0.14626 0.82835 2.54680 0.19794 65 0.98336 3.98623 0.20703 93 0.28643 -0.54116 153.133 0.58918 0.67955
Nicotinate-nucleotide diphosphorylase (carboxylating) 0.91959 0.14626 0.82835 2.54680 0.19794 65 0.98336 3.98623 0.20703 93 0.28643 -0.54116 153.133 0.58918 0.67955
Quinolinate synthase 0.91959 0.14626 0.82835 2.54680 0.19794 65 0.98336 3.98623 0.20703 93 0.28643 -0.54116 153.133 0.58918 0.67955
Nicotinate phosphoribosyltransferase 0.91896 0.13166 0.79725 1.80641 0.16671 65 1.00403 3.39979 0.19120 93 0.25367 -0.81516 155.699 0.41623 0.57933
3-deoxy-manno-octulosonate cytidylyltransferase 0.91384 0.12900 0.78658 1.71297 0.16234 65 1.00278 3.27573 0.18768 93 0.24815 -0.87127 155.798 0.38495 0.57933
Methionine adenosyltransferase 0.91384 0.12900 0.78658 1.71297 0.16234 65 1.00278 3.27573 0.18768 93 0.24815 -0.87127 155.798 0.38495 0.57933
Amidophosphoribosyltransferase 0.91268 0.13560 0.79756 2.08608 0.17915 65 0.99314 3.49048 0.19373 93 0.26387 -0.74121 154.361 0.45969 0.57933
UDP-glucose 6-dehydrogenase 0.91268 0.13560 0.79756 2.08608 0.17915 65 0.99314 3.49048 0.19373 93 0.26387 -0.74121 154.361 0.45969 0.57933
Phosphoribosylglycinamide formyltransferase 0.91264 0.13560 0.79745 2.08624 0.17915 65 0.99314 3.49048 0.19373 93 0.26387 -0.74160 154.360 0.45946 0.57933
Ribonuclease III 0.90929 0.13167 0.79571 1.80479 0.16663 65 0.98867 3.40350 0.19130 93 0.25370 -0.76058 155.712 0.44806 0.57933
3-methyl-2-oxobutanoate hydroxymethyltransferase 0.90861 0.13122 0.79736 1.80623 0.16670 65 0.98637 3.37159 0.19040 93 0.25306 -0.74686 155.640 0.45627 0.57933
Aspartate 1-decarboxylase 0.90861 0.13122 0.79736 1.80623 0.16670 65 0.98637 3.37159 0.19040 93 0.25306 -0.74686 155.640 0.45627 0.57933
Pantoate–beta-alanine ligase (AMP-forming) 0.90861 0.13122 0.79736 1.80623 0.16670 65 0.98637 3.37159 0.19040 93 0.25306 -0.74686 155.640 0.45627 0.57933
Phosphopantothenate–cysteine ligase 0.90861 0.13122 0.79736 1.80623 0.16670 65 0.98637 3.37159 0.19040 93 0.25306 -0.74686 155.640 0.45627 0.57933
Phosphopantothenoylcysteine decarboxylase 0.90861 0.13122 0.79736 1.80623 0.16670 65 0.98637 3.37159 0.19040 93 0.25306 -0.74686 155.640 0.45627 0.57933
UDP-glucose 4-epimerase 0.90853 0.12890 0.78271 1.72754 0.16303 65 0.99648 3.25921 0.18720 93 0.24824 -0.86115 155.715 0.39048 0.57933
16S rRNA (cytidine(1402)-2’-O)-methyltransferase 0.90849 0.12890 0.78260 1.72771 0.16303 65 0.99648 3.25921 0.18720 93 0.24824 -0.86156 155.715 0.39025 0.57933
3’(2’),5’-bisphosphate nucleotidase 0.90849 0.12890 0.78260 1.72771 0.16303 65 0.99648 3.25921 0.18720 93 0.24824 -0.86156 155.715 0.39025 0.57933
3-deoxy-manno-octulosonate-8-phosphatase 0.90740 0.13199 0.78631 1.82382 0.16751 65 0.99203 3.41117 0.19152 93 0.25444 -0.80851 155.655 0.42003 0.57933
Glutamine–fructose-6-phosphate transaminase (isomerizing) 0.90699 0.13614 0.78071 1.91050 0.17144 65 0.99524 3.64942 0.19809 93 0.26198 -0.81890 155.792 0.41410 0.57933
Fructan beta-fructosidase 0.90382 0.13636 0.76536 1.91458 0.17162 65 1.00060 3.65856 0.19834 93 0.26229 -0.89689 155.794 0.37116 0.57933
Protein-tyrosine-phosphatase 0.90025 0.13104 0.77758 1.79285 0.16608 65 0.98598 3.36442 0.19020 93 0.25251 -0.82533 155.679 0.41045 0.57933
Diaminopimelate dehydrogenase 0.89821 0.12715 0.78033 1.67989 0.16076 65 0.98061 3.17398 0.18474 93 0.24489 -0.81781 155.725 0.41472 0.57933
Phosphoglycerate dehydrogenase 0.89821 0.12715 0.78033 1.67989 0.16076 65 0.98061 3.17398 0.18474 93 0.24489 -0.81781 155.725 0.41472 0.57933
Phosphoserine transaminase 0.89821 0.12715 0.78033 1.67989 0.16076 65 0.98061 3.17398 0.18474 93 0.24489 -0.81781 155.725 0.41472 0.57933
Uroporphyrinogen-III synthase 0.89736 0.12823 0.76987 1.68381 0.16095 65 0.98647 3.24299 0.18674 93 0.24653 -0.87860 155.836 0.38097 0.57933
Bacterial non-heme ferritin 0.89708 0.13071 0.78418 1.77498 0.16525 65 0.97600 3.35692 0.18999 93 0.25180 -0.76181 155.731 0.44733 0.57933
Enoyl-[acyl-carrier-protein] reductase (NADH) 0.89708 0.13071 0.78418 1.77498 0.16525 65 0.97600 3.35692 0.18999 93 0.25180 -0.76181 155.731 0.44733 0.57933
Enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) 0.89708 0.13071 0.78418 1.77498 0.16525 65 0.97600 3.35692 0.18999 93 0.25180 -0.76181 155.731 0.44733 0.57933
o-succinylbenzoate–CoA ligase 0.89708 0.13071 0.78418 1.77498 0.16525 65 0.97600 3.35692 0.18999 93 0.25180 -0.76181 155.731 0.44733 0.57933
Phosphoribosylanthranilate isomerase 0.89708 0.13071 0.78418 1.77498 0.16525 65 0.97600 3.35692 0.18999 93 0.25180 -0.76181 155.731 0.44733 0.57933
Lipoyl synthase 0.89695 0.13680 0.77860 2.16725 0.18260 65 0.97966 3.52170 0.19460 93 0.26685 -0.75348 153.863 0.45231 0.57933
Aminodeoxychorismate lyase 0.88973 0.14169 0.80853 2.36590 0.19078 65 0.94648 3.75928 0.20105 93 0.27717 -0.49771 153.439 0.61940 0.70008
Aminodeoxychorismate synthase 0.88973 0.14169 0.80853 2.36590 0.19078 65 0.94648 3.75928 0.20105 93 0.27717 -0.49771 153.439 0.61940 0.70008
3,4-dihydroxy-2-butanone-4-phosphate synthase 0.88928 0.12710 0.77358 1.68098 0.16081 65 0.97015 3.17056 0.18464 93 0.24485 -0.80281 155.713 0.42331 0.57933
Histidine kinase 0.88907 0.12710 0.77358 1.68098 0.16081 65 0.96978 3.17023 0.18463 93 0.24485 -0.80132 155.713 0.42417 0.57933
GTP cyclohydrolase II 0.88754 0.12713 0.76987 1.68381 0.16095 65 0.96978 3.16970 0.18462 93 0.24492 -0.81623 155.700 0.41562 0.57933
(2E,6E)-farnesyl diphosphate synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
(Kdo)-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
(Kdo)(2)-lipid IV(A) (2-8) 3-deoxy-D-manno-octulosonic acid transferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
(Kdo)(3)-lipid IV(A) (2-4) 3-deoxy-D-manno-octulosonic acid transferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
[Acyl-carrier-protein] S-malonyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
[Ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
1-acylglycerol-3-phosphate O-acyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
1-deoxy-D-xylulose-5-phosphate reductoisomerase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
1,4-alpha-glucan branching enzyme 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
1,4-dihydroxy-2-naphthoate polyprenyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
1,4-dihydroxy-2-naphthoyl-CoA synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
16S rRNA (cytosine(1402)-N(4))-methyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
16S rRNA (guanine(527)-N(7))-methyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
16S rRNA (uracil(1498)-N(3))-methyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
2-iminobutanoate/2-iminopropanoate deaminase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
23S rRNA (adenine(2503)-C(2))-methyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
23S rRNA (cytosine(1962)-C(5))-methyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
23S rRNA (pseudouridine(1915)-N(3))-methyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
23S rRNA (uracil(1939)-C(5))-methyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
23S rRNA pseudouridine(2605) synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
3-dehydroquinate dehydratase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
3-dehydroquinate synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
3-deoxy-8-phosphooctulonate synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
3-phosphoshikimate 1-carboxyvinyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol kinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
4-alpha-glucanotransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
4-hydroxy-tetrahydrodipicolinate reductase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
4-hydroxy-tetrahydrodipicolinate synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
4-hydroxythreonine-4-phosphate dehydrogenase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
5-(carboxyamino)imidazole ribonucleotide mutase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
5-amino-6-(5-phosphoribosylamino)uracil reductase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
5-formyltetrahydrofolate cyclo-ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
6-phosphofructokinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
6,7-dimethyl-8-ribityllumazine synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
7-cyano-7-deazaguanine synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Acetate kinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
acetylglucosaminyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Adenine phosphoribosyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Adenosylhomocysteine nucleosidase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Adenylate kinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Adenylosuccinate lyase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Adenylosuccinate synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Alanine–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Alanine racemase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
All-trans-octaprenyl-diphosphate synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Aminoacyl-tRNA hydrolase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Arabinose-5-phosphate isomerase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Arginine–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Arginine decarboxylase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Asparagine–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Aspartate–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Aspartate-semialdehyde dehydrogenase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Aspartate carbamoyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Beta-ketoacyl-[acyl-carrier-protein] synthase II 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Biotin–[acetyl-CoA-carboxylase] ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Branched-chain-amino-acid transaminase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Carboxynorspermidine decarboxylase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
CDP-diacylglycerol–serine O-phosphatidyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Chorismate mutase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Chorismate synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Crossover junction endodeoxyribonuclease 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
CTP synthase (glutamine hydrolyzing) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Cysteine–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Cysteine desulfurase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Cytidine deaminase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
D-alanine–D-alanine ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
dCMP deaminase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Demethylmenaquinone methyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Deoxyribose-phosphate aldolase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
dGTPase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Diamine N-acetyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Diaminohydroxyphosphoribosylaminopyrimidine deaminase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Dihydrofolate synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Dihydroneopterin aldolase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Dihydroorotate dehydrogenase (NAD(+)) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Dihydropteroate synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Dimethylallyltranstransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Dipeptidyl-peptidase III 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Diphosphate–fructose-6-phosphate 1-phosphotransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
diphosphate specific) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
DNA ligase (NAD(+)) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Dolichyl-phosphate beta-D-mannosyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
dTDP-4-dehydrorhamnose 3,5-epimerase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
dTDP-4-dehydrorhamnose reductase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
dTDP-glucose 4,6-dehydratase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
dUTP diphosphatase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Endopeptidase Clp 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Epoxyqueuosine reductase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
FAD synthetase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
FMN reductase (NAD(P)H) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Fructose-bisphosphatase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Fructose-bisphosphate aldolase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
GDP-L-fucose synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
GDP-mannose 4,6-dehydratase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Geranylgeranyl diphosphate synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Glucose-1-phosphate thymidylyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Glucose-6-phosphate isomerase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Glutamate–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Glutamate racemase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Glutamine–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Glycerate dehydrogenase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Glycine–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Glycine hydroxymethyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Glycogen phosphorylase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
GMP synthase (glutamine-hydrolyzing) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Guanylate kinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Histidine–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Hypoxanthine phosphoribosyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
IMP dehydrogenase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Iron-chelate-transporting ATPase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Isochorismate synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Kdo(2)-lipid IV(A) lauroyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
L-serine ammonia-lyase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
L-threonylcarbamoyladenylate synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Lipid-A-disaccharide synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Lysine–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Malate dehydrogenase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Mannose-6-phosphate isomerase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Methenyltetrahydrofolate cyclohydrolase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Methionine–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Methionyl-tRNA formyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Methylated-DNA–[protein]-cysteine S-methyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Methylenetetrahydrofolate dehydrogenase (NADP(+)) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
N-carbamoylputrescine amidase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
N(6)-L-threonylcarbamoyladenine synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
NAD(+) diphosphatase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
NAD(+) kinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
NAD(+) synthase (glutamine-hydrolyzing) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
NAD(P)H-hydrate epimerase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Nicotinamide-nucleotide amidase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Nicotinate-nucleotide adenylyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Oligonucleotidase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Orotate phosphoribosyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Orotidine-5’-phosphate decarboxylase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Pantetheine-phosphate adenylyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Pantothenate kinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Peptide-methionine (R)-S-oxide reductase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Peptide-methionine (S)-S-oxide reductase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Peptide chain release factor N(5)-glutamine methyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Peptide deformylase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Phosphate acetyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Phosphatidate cytidylyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Phosphatidylserine decarboxylase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Phospho-N-acetylmuramoyl-pentapeptide-transferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Phosphoenolpyruvate carboxykinase (ATP) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Phosphoglycerate kinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Phosphomannomutase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Phosphopyruvate hydratase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Phosphoribosylamine–glycine ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Phosphoribosylformylglycinamidine cyclo-ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Polyribonucleotide nucleotidyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
PreQ(1) synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Proline–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Protein-disulfide reductase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Purine-nucleoside phosphorylase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Pyruvate carboxylase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Pyruvate kinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Pyruvate synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Pyruvate, phosphate dikinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Riboflavin kinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Riboflavin synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Ribonuclease P 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Ribonuclease Z 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Ribonucleoside-triphosphate reductase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Ribose-5-phosphate isomerase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Ribose-phosphate diphosphokinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Ribulose-phosphate 3-epimerase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
RNA helicase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Saccharopine dehydrogenase (NAD(+), L-lysine-forming) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Selenocysteine lyase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Serine–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Shikimate dehydrogenase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Shikimate kinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Signal peptidase II 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Starch synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Tetraacyldisaccharide 4’-kinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Tetrahydrofolate synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Thiamine-phosphate kinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Thioredoxin-disulfide reductase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Threonine–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Thymidine kinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Tripeptide aminopeptidase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
tRNA-guanine(34) transglycosylase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
tRNA (guanine(37)-N(1))-methyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
tRNA (guanine(46)-N(7))-methyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
tRNA pseudouridine(38-40) synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
tRNA pseudouridine(55) synthase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
tRNA(adenine(34)) deaminase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
tRNA(Ile)-lysidine synthetase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Tryptophan–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Tyrosine–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
UDP-2,3-diacylglucosamine diphosphatase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
UDP-3-O-acyl-N-acetylglucosamine deacetylase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
UDP-N-acetylmuramate–L-alanine ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
UDP-N-acetylmuramate dehydrogenase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
UDP-N-acetylmuramoyl-L-alanine–D-glutamate ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
UMP kinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
UMP/CMP kinase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Uracil phosphoribosyltransferase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Uridine phosphorylase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Valine–tRNA ligase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.57933
Pullulanase 0.88296 0.13528 0.75567 1.87450 0.16982 65 0.97192 3.61109 0.19705 93 0.26013 -0.83133 155.837 0.40706 0.57933
Tryptophan synthase 0.87661 0.12769 0.76128 1.60201 0.15699 65 0.95721 3.26565 0.18739 93 0.24446 -0.80148 155.997 0.42407 0.57933
Formate–tetrahydrofolate ligase 0.87335 0.13145 0.74187 1.77574 0.16528 65 0.96525 3.40283 0.19128 93 0.25280 -0.88361 155.809 0.37827 0.57933
S-ribosylhomocysteine lyase 0.87335 0.13145 0.74187 1.77574 0.16528 65 0.96525 3.40283 0.19128 93 0.25280 -0.88361 155.809 0.37827 0.57933
Aminomethyltransferase 0.87053 0.13523 0.77525 2.16160 0.18236 65 0.93712 3.41585 0.19165 93 0.26455 -0.61187 153.329 0.54153 0.63989
Dihydrolipoyl dehydrogenase 0.87053 0.13523 0.77525 2.16160 0.18236 65 0.93712 3.41585 0.19165 93 0.26455 -0.61187 153.329 0.54153 0.63989
Anthranilate synthase 0.86390 0.14139 0.78231 2.54045 0.19770 65 0.92092 3.61461 0.19715 93 0.27920 -0.49648 150.822 0.62028 0.70008
Galactokinase 0.84006 0.10980 0.73174 1.12392 0.13150 65 0.91577 2.45463 0.16246 93 0.20901 -0.88050 155.866 0.37994 0.57933
Calcium-transporting ATPase 0.82149 0.11978 0.74746 1.68326 0.16092 65 0.87324 2.69117 0.17011 93 0.23417 -0.53717 153.559 0.59193 0.68001
Xanthine phosphoribosyltransferase 0.82149 0.11978 0.74746 1.68326 0.16092 65 0.87324 2.69117 0.17011 93 0.23417 -0.53717 153.559 0.59193 0.68001
NADH dehydrogenase 0.81739 0.11537 0.71828 1.18617 0.13509 65 0.88667 2.75203 0.17202 93 0.21872 -0.76987 155.467 0.44254 0.57933
Non-reducing end alpha-L-arabinofuranosidase 0.81190 0.23710 0.51200 1.60636 0.15720 65 1.02151 13.93258 0.38706 93 0.41776 -1.21960 120.156 0.22500 0.57933
Mannonate dehydratase 0.81165 0.23711 0.51138 1.60692 0.15723 65 1.02151 13.93258 0.38706 93 0.41777 -1.22105 120.165 0.22446 0.57933
Xylulokinase 0.79873 0.22090 0.55949 2.78800 0.20710 65 0.96595 11.14889 0.34624 93 0.40345 -1.00746 143.250 0.31541 0.57933
Cysteine synthase 0.78473 0.11908 0.66808 1.20008 0.13588 65 0.86626 2.97209 0.17877 93 0.22455 -0.88261 154.757 0.37882 0.57933
Diaminopimelate decarboxylase 0.77790 0.11572 0.65612 1.15146 0.13310 65 0.86301 2.79168 0.17326 93 0.21848 -0.94695 155.019 0.34514 0.57933
Homoserine dehydrogenase 0.77790 0.11572 0.65612 1.15146 0.13310 65 0.86301 2.79168 0.17326 93 0.21848 -0.94695 155.019 0.34514 0.57933
Homoserine O-succinyltransferase 0.77790 0.11572 0.65612 1.15146 0.13310 65 0.86301 2.79168 0.17326 93 0.21848 -0.94695 155.019 0.34514 0.57933
Nitric-oxide reductase (cytochrome c) 0.77532 0.18790 0.80000 4.34219 0.25846 65 0.75806 6.49790 0.26433 93 0.36969 0.11343 152.123 0.90984 0.94070
Beta-lactamase 0.76582 0.21622 0.63590 1.76640 0.16485 65 0.85663 11.35603 0.34944 93 0.38637 -0.57130 128.367 0.56880 0.66830
Glucosylceramidase 0.73418 0.49184 0.80000 41.60000 0.80000 65 0.68817 36.28214 0.62460 93 1.01495 0.11018 131.751 0.91243 0.94070
(4S)-4-hydroxy-2-oxoglutarate aldolase 0.72622 0.19784 0.47956 2.04833 0.17752 65 0.89862 9.05571 0.31205 93 0.35901 -1.16727 140.092 0.24509 0.57933
2-dehydro-3-deoxy-phosphogluconate aldolase 0.72622 0.19784 0.47956 2.04833 0.17752 65 0.89862 9.05571 0.31205 93 0.35901 -1.16727 140.092 0.24509 0.57933
Alpha-D-xyloside xylohydrolase 0.72369 0.19004 0.48659 2.04561 0.17740 65 0.88940 8.24762 0.29780 93 0.34663 -1.16205 142.995 0.24715 0.57933
Dihydroxy-acid dehydratase 0.68553 0.18938 0.47956 2.04833 0.17752 65 0.82949 8.19488 0.29685 93 0.34588 -1.01173 143.235 0.31337 0.57933
Gluconate 5-dehydrogenase 0.68553 0.18951 0.48176 2.07329 0.17860 65 0.82796 8.19102 0.29678 93 0.34637 -0.99951 143.624 0.31923 0.57933
Ketol-acid reductoisomerase (NADP(+)) 0.68553 0.18938 0.47956 2.04833 0.17752 65 0.82949 8.19488 0.29685 93 0.34588 -1.01173 143.235 0.31337 0.57933
Glycerophosphodiester phosphodiesterase 0.68291 0.16114 0.44462 0.89958 0.11764 65 0.84946 6.30692 0.26042 93 0.28576 -1.41676 125.847 0.15902 0.57933
6-carboxytetrahydropterin synthase 0.68241 0.14779 0.53108 1.53653 0.15375 65 0.78817 4.79279 0.22701 93 0.27418 -0.93769 150.299 0.34991 0.57933
6-pyruvoyltetrahydropterin synthase 0.68241 0.14779 0.53108 1.53653 0.15375 65 0.78817 4.79279 0.22701 93 0.27418 -0.93769 150.299 0.34991 0.57933
UDP-galactopyranose mutase 0.66237 0.13315 0.53594 1.44317 0.14901 65 0.75073 3.75708 0.20099 93 0.25020 -0.85846 154.033 0.39197 0.57933
Arabinogalactan endo-beta-1,4-galactanase 0.63648 0.16168 0.46601 1.35653 0.14446 65 0.75562 6.06953 0.25547 93 0.29349 -0.98679 139.710 0.32545 0.57933
Threonine synthase 0.63386 0.16633 0.42538 1.56647 0.15524 65 0.77957 6.31739 0.26063 93 0.30336 -1.16753 142.987 0.24494 0.57933
Arabinan endo-1,5-alpha-L-arabinosidase 0.62841 0.14992 0.43179 1.32576 0.14282 65 0.76583 5.09164 0.23398 93 0.27413 -1.21855 144.489 0.22500 0.57933
4-phosphoerythronate dehydrogenase 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.57933
8-amino-7-oxononanoate synthase 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.57933
Adenylyl-sulfate kinase 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.57933
AMP nucleosidase 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.57933
Exodeoxyribonuclease V 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.57933
Nucleoside-diphosphate kinase 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.57933
Polynucleotide adenylyltransferase 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.57933
Pyridoxine 5’-phosphate synthase 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.57933
Adenosylcobalamin/alpha-ribazole phosphatase 0.59351 0.15114 0.37731 0.75533 0.10780 65 0.74462 5.57742 0.24489 93 0.26757 -1.37279 124.393 0.17229 0.57933
Adenosylcobinamide-GDP ribazoletransferase 0.59351 0.15114 0.37731 0.75533 0.10780 65 0.74462 5.57742 0.24489 93 0.26757 -1.37279 124.393 0.17229 0.57933
Adenosylcobinamide-phosphate guanylyltransferase 0.59351 0.15114 0.37731 0.75533 0.10780 65 0.74462 5.57742 0.24489 93 0.26757 -1.37279 124.393 0.17229 0.57933
Adenosylcobinamide kinase 0.59351 0.15114 0.37731 0.75533 0.10780 65 0.74462 5.57742 0.24489 93 0.26757 -1.37279 124.393 0.17229 0.57933
Nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase 0.59351 0.15114 0.37731 0.75533 0.10780 65 0.74462 5.57742 0.24489 93 0.26757 -1.37279 124.393 0.17229 0.57933
Superoxide dismutase 0.58763 0.11111 0.45680 0.92527 0.11931 65 0.67907 2.66422 0.16926 93 0.20708 -1.07334 152.144 0.28482 0.57933
Alpha-L-rhamnosidase 0.58228 0.27015 0.47692 9.34712 0.37921 65 0.65591 13.16293 0.37621 93 0.53417 -0.33508 150.536 0.73803 0.80172
Nitrous-oxide reductase 0.58228 0.27015 0.47692 9.34712 0.37921 65 0.65591 13.16293 0.37621 93 0.53417 -0.33508 150.536 0.73803 0.80172
Prephenate dehydratase 0.54437 0.11659 0.35530 0.54727 0.09176 65 0.67652 3.24171 0.18670 93 0.20803 -1.54412 130.839 0.12497 0.57933
CDP-glycerol glycerophosphotransferase 0.52532 0.36271 0.55385 16.84471 0.50907 65 0.50538 23.75269 0.50538 93 0.71732 0.06757 150.573 0.94622 0.95115
Phosphatidylglycerophosphatase 0.52363 0.14626 0.51897 1.94007 0.17276 65 0.52688 4.41865 0.21797 93 0.27814 -0.02843 155.616 0.97736 0.97905
Lysozyme 0.51899 0.11395 0.53077 1.59279 0.15654 65 0.51075 2.39255 0.16039 93 0.22412 0.08931 152.213 0.92895 0.94070
Leucyltransferase 0.51730 0.12525 0.53436 1.92882 0.17226 65 0.50538 2.88795 0.17622 93 0.24643 0.11761 152.136 0.90653 0.94070
N-acetylmuramic acid 6-phosphate etherase 0.47710 0.11628 0.28839 0.40133 0.07858 65 0.60899 3.32371 0.18905 93 0.20473 -1.56599 121.329 0.11995 0.57933
(R)-2-methylmalate dehydratase 0.47532 0.26003 0.44769 10.49972 0.40191 65 0.49462 10.92660 0.34277 93 0.52823 -0.08885 139.587 0.92933 0.94070
3-isopropylmalate dehydratase 0.47532 0.26003 0.44769 10.49972 0.40191 65 0.49462 10.92660 0.34277 93 0.52823 -0.08885 139.587 0.92933 0.94070
Xylose isomerase 0.47152 0.26006 0.44615 10.50096 0.40194 65 0.48925 10.92923 0.34281 93 0.52827 -0.08157 139.592 0.93510 0.94325
Glucuronate isomerase 0.46722 0.12602 0.26338 0.40408 0.07885 65 0.60968 3.95088 0.20611 93 0.22068 -1.56921 117.285 0.11929 0.57933
CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase 0.46076 0.11582 0.40077 1.08496 0.12920 65 0.50269 2.85801 0.17530 93 0.21777 -0.46802 153.840 0.64044 0.71863
Dipeptidase E 0.41845 0.10157 0.27811 0.46453 0.08454 65 0.51654 2.43470 0.16180 93 0.18255 -1.30611 134.660 0.19374 0.57933
L-rhamnose mutarotase 0.41139 0.17535 0.23077 1.67248 0.16041 65 0.53763 7.08824 0.27608 93 0.31929 -0.96108 141.431 0.33815 0.57933
Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) 0.39873 0.09404 0.40769 1.08314 0.12909 65 0.39247 1.63098 0.13243 93 0.18494 0.08229 152.271 0.93452 0.94325
Cellobiose phosphorylase 0.36772 0.24592 0.40154 10.39890 0.39998 65 0.34409 9.07054 0.31230 93 0.50746 0.11322 131.756 0.91003 0.94070
Diaminopimelate epimerase 0.35994 0.06710 0.28031 0.45305 0.08349 65 0.41559 0.89130 0.09790 93 0.12866 -1.05147 155.925 0.29467 0.57933
LL-diaminopimelate aminotransferase 0.35994 0.06710 0.28031 0.45305 0.08349 65 0.41559 0.89130 0.09790 93 0.12866 -1.05147 155.925 0.29467 0.57933
Anthranilate phosphoribosyltransferase 0.31477 0.17337 0.29846 4.66654 0.26794 65 0.32616 4.85744 0.22854 93 0.35217 -0.07866 139.597 0.93741 0.94393
Lipoate–protein ligase 0.30922 0.09671 0.19121 0.96829 0.12205 65 0.39171 1.83137 0.14033 93 0.18598 -1.07805 155.732 0.28268 0.57933
Creatininase 0.27215 0.16573 0.04615 0.04471 0.02623 65 0.43011 7.31300 0.28042 93 0.28164 -1.36327 93.606 0.17607 0.57933
Exo-1,4-beta-D-glucosaminidase 0.27215 0.16573 0.04615 0.04471 0.02623 65 0.43011 7.31300 0.28042 93 0.28164 -1.36327 93.606 0.17607 0.57933
N-acetylneuraminate synthase 0.27215 0.16573 0.04615 0.04471 0.02623 65 0.43011 7.31300 0.28042 93 0.28164 -1.36327 93.606 0.17607 0.57933
N-acylneuraminate cytidylyltransferase 0.27215 0.16573 0.04615 0.04471 0.02623 65 0.43011 7.31300 0.28042 93 0.28164 -1.36327 93.606 0.17607 0.57933
RNA ligase (ATP) 0.27215 0.16573 0.04615 0.04471 0.02623 65 0.43011 7.31300 0.28042 93 0.28164 -1.36327 93.606 0.17607 0.57933
Beta-fructofuranosidase 0.26846 0.05911 0.19487 0.46751 0.08481 65 0.31989 0.61040 0.08102 93 0.11729 -1.06595 148.231 0.28818 0.57933
Dextranase 0.26772 0.06391 0.22462 0.67001 0.10153 65 0.29785 0.63304 0.08250 93 0.13082 -0.55979 135.370 0.57654 0.67302
L-threonine aldolase 0.26498 0.09697 0.23897 1.40165 0.14685 65 0.28315 1.55965 0.12950 93 0.19579 -0.22565 142.358 0.82180 0.87628
(R)-citramalate synthase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
2-isopropylmalate synthase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
3-isopropylmalate dehydrogenase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
Acetylglutamate kinase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
Acetylornithine deacetylase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
Acetylornithine transaminase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
Argininosuccinate lyase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
Argininosuccinate synthase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
ATP phosphoribosyltransferase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
Histidinol-phosphatase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
Histidinol dehydrogenase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
Imidazoleglycerol-phosphate dehydratase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
isomerase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
N-acetyl-gamma-glutamyl-phosphate reductase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
N-succinylornithine carbamoyltransferase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
Phosphoribosyl-AMP cyclohydrolase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
Phosphoribosyl-ATP diphosphatase 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94070
Lactoylglutathione lyase 0.23259 0.08954 0.11154 0.39069 0.07753 65 0.31720 1.87247 0.14189 93 0.16169 -1.27195 137.511 0.20554 0.57933
Pyrroline-5-carboxylate reductase 0.19968 0.12364 0.21615 2.60298 0.20011 65 0.18817 2.31067 0.15763 93 0.25474 0.10985 132.556 0.91270 0.94070
Hippurate hydrolase 0.17089 0.13785 0.05385 0.18846 0.05385 65 0.25269 4.97622 0.23132 93 0.23750 -0.83722 101.811 0.40443 0.57933
Potassium-transporting ATPase 0.15190 0.13414 0.32308 6.78462 0.32308 65 0.03226 0.09677 0.03226 93 0.32468 0.89570 65.278 0.37370 0.57933
Type III site-specific deoxyribonuclease 0.14620 0.13620 0.00154 0.00015 0.00154 65 0.24731 4.97622 0.23132 93 0.23132 -1.06247 92.008 0.29080 0.57933
Polar-amino-acid-transporting ATPase 0.13671 0.08286 0.02462 0.01126 0.01316 65 0.21505 1.82825 0.14021 93 0.14083 -1.35230 93.618 0.17954 0.57933
Aconitate hydratase 0.06677 0.04503 0.05077 0.08043 0.03518 65 0.07796 0.49046 0.07262 93 0.08069 -0.33693 129.952 0.73671 0.80172
Isocitrate dehydrogenase (NADP(+)) 0.06677 0.04503 0.05077 0.08043 0.03518 65 0.07796 0.49046 0.07262 93 0.08069 -0.33693 129.952 0.73671 0.80172
Citrate CoA-transferase 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.57933
Citrate lyase holo-[acyl-carrier protein] synthase 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.57933
Citryl-CoA lyase 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.57933
RNA-directed DNA polymerase 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.57933
2-iminoacetate synthase 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.57933
Asparagine synthase (glutamine-hydrolyzing) 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.57933
Aspartyl aminopeptidase 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.57933
Cellulase 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.57933
Citrate (Si)-synthase 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.57933
D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.57933
D-glycero-alpha-D-manno-heptose-7-phosphate kinase 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.57933
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.57933
D-sedoheptulose 7-phosphate isomerase 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.57933
Endo-1,4-beta-xylanase 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.57933
Glutamate-5-semialdehyde dehydrogenase 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.57933
Glutamate 5-kinase 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.57933
Phosphoadenylyl-sulfate reductase (thioredoxin) 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.57933
Prolyl aminopeptidase 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.57933
Thiazole synthase 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.57933 
plot.dat <- tb.ra %>%
  arrange(p) %>%
  slice_head(n=50)%>%
  mutate(
    description = fct_reorder(description, `Overall Mean`),
    description = factor(description, levels = levels(description), ordered=T)
  ) %>%
  arrange(description) %>%
  mutate(
    id = 1:n(),
    step = ifelse(id%%2 == 0, 1, 0),
    Mean_diff = `Tumor Mean` - `Non-Tumor Mean`,
    diff_se = SEpooled,
    Mean_diff_ll = Mean_diff - qt(0.975, df)*diff_se,
    Mean_diff_ul = Mean_diff + qt(0.975, df)*diff_se
  ) %>%
  pivot_longer(
    cols=contains("Mean"),
    names_to = "group",
    values_to = "mean"
  )



p1.d <- plot.dat %>%
  filter(group %in% c("Tumor Mean","Non-Tumor Mean")) %>%
  mutate(
    group = ifelse(group == "Tumor Mean", "Tumor", "Non-Tumor"),
    col = ifelse(step == 1, "grey90", "white"),
    h=1, w=Inf
    
  )
p1 <- ggplot()+
  geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_bar(data=p1.d,
             aes(x=mean, y=description,
                 group=group, color=group,
                 fill=group),
             stat="identity",position = "dodge",
             alpha = 1)+
    labs(x="Mean Abundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      plot.margin = unit(c(1,0,1,1), "lines")
    )

p2.d <- plot.dat %>%
  filter(group %in% c("Mean_diff", "Mean_diff_ll", "Mean_diff_ul")) %>%
  pivot_wider(
    names_from = group,
    values_from = mean
  ) %>%
  mutate(
    group = ifelse(Mean_diff > 0, "Tumor", "Non-Tumor"),
    p = sprintf("%.3f", round(p,3)),
    ll = min(Mean_diff_ll)-0.01,
    ul = max(Mean_diff_ul)+0.01
  )
p2<-ggplot(p2.d, aes(x=Mean_diff, y=description))+
    geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_vline(xintercept = 0, linetype="dashed", alpha=0.5)+
    geom_segment(aes(x=Mean_diff_ll, y=description, xend=Mean_diff_ul, yend=description))+
    geom_point(aes(fill=group, color=group))+
    geom_text(aes(label=p, x=unique(ul)+0.1))+
    coord_cartesian(xlim = c(unique(p2.d$ll), unique(p2.d$ul)),
                    clip = 'off') +
    annotate("text", x=unique(p2.d$ul)+0.2,y = 25,
             angle=90,
             label="p-value (uncorrected)")+
    labs(x="Mean Difference in Abundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      axis.title.y = element_blank(),
      axis.text.y = element_blank(),
      axis.line.y = element_blank(),
      axis.ticks.y = element_blank(),
      plot.margin = unit(c(1,4,1,0), "lines")
    )

# plot
p1 + p2 +
  plot_annotation(title="Stratefied EC Data - Prevotella spp. (genus level only): First 50 descriptions with lowest p-value (uncorrected)")

Modeling Difference between Tumor and Non-Tumor

For the modeling, we used a generalized linear mixed model (GLMM).

First, we looked at the biserial correlation between the abundance of each description and the tumor status.

tb <- mydata %>%
  group_by(description)%>%
  summarise(
    r = cor(tumor, Abundance)
  ) %>%
  mutate(
    M=mean(r)
  )

ggplot(tb, aes(x=r))+
  geom_density()+
  geom_vline(aes(xintercept = M))+
  labs(x="Biserial Correlation",title="Relationship between description abundance and tumor (tumor vs. non-tumor)")+
  theme(panel.grid = element_blank())

Next, we need the data to be on an interpretable scale. First, let’s use the raw abundance like scale.

p <- ggplot(mydata, aes(x=Abundance))+
  geom_density()
p

mydata <- mydata %>%
  mutate(Abundance.dich=ifelse(Abundance==0, 0, 1))
table(mydata$Abundance.dich)

    0     1 
38726 52756

Let’s first run models by description so that we can avoid the nesting issue initially. We will come back to this to conduct the final model (it will be more powerful).

DESCRIPTIONS <- unique(mydata$description)
i<-1
dat0 <- mydata %>% filter(description==DESCRIPTIONS[i])

# quasipossion (approximately negative binom) give an approx. answer.
fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
summary(fit0)

Call:
glm(formula = Abundance ~ 1 + tumor, family = quasipoisson(link = "log"), 
    data = dat0)

Deviance Residuals: 
   Min      1Q  Median      3Q     Max  
-1.392  -1.241  -0.906   0.232   5.513  

Coefficients:
            Estimate Std. Error t value Pr(>|t|)
(Intercept)  -0.0311     0.1770   -0.18     0.86
tumor        -0.2305     0.2963   -0.78     0.44

(Dispersion parameter for quasipoisson family taken to be 2.8254)

    Null deviance: 293.35  on 157  degrees of freedom
Residual deviance: 291.61  on 156  degrees of freedom
AIC: NA

Number of Fisher Scoring iterations: 6

Run over all descriptors

results.out <- as.data.frame(matrix(ncol=4, nrow=length(DESCRIPTIONS)))
colnames(results.out) <- c("description", "Est", "SE", "p")
#results.out$description <-DESCRIPTIONS

i <- 1
for(i in 1:length(DESCRIPTIONS)){
#for(i in 1:5){ 
  dat0 <- mydata %>%
    filter(description == DESCRIPTIONS[i])
  fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
  fit.sum <- summary(fit0)
  results.out[i, 1] <- DESCRIPTIONS[i]
  results.out[i, 2:4] <- fit.sum$coefficients[2, c(1,2,4)]
}

results.out$fdr_p <- p.adjust(results.out$p, method="fdr")

kable(results.out, format="html", digits=3) %>%
  kable_styling(full_width = T)%>%
  scroll_box(width="100%", height="600px")
description Est SE p fdr_p
(2E,6E)-farnesyl diphosphate synthase -0.230 0.296 0.438 0.635
(4S)-4-hydroxy-2-oxoglutarate aldolase -0.628 0.582 0.282 0.635
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin) -0.230 0.296 0.438 0.635
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) -0.230 0.296 0.438 0.635
(Kdo)-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -0.230 0.296 0.438 0.635
(Kdo)(2)-lipid IV(A) (2-8) 3-deoxy-D-manno-octulosonic acid transferase -0.230 0.296 0.438 0.635
(Kdo)(3)-lipid IV(A) (2-4) 3-deoxy-D-manno-octulosonic acid transferase -0.230 0.296 0.438 0.635
(R)-2-methylmalate dehydratase -0.100 1.127 0.930 0.968
(R)-citramalate synthase -0.100 1.127 0.930 0.968
[Acyl-carrier-protein] S-malonyltransferase -0.230 0.296 0.438 0.635
[Formate-C-acetyltransferase]-activating enzyme -0.204 0.299 0.496 0.635
[Ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase -0.230 0.296 0.438 0.635
1-acylglycerol-3-phosphate O-acyltransferase -0.230 0.296 0.438 0.635
1-deoxy-D-xylulose-5-phosphate reductoisomerase -0.230 0.296 0.438 0.635
1-deoxy-D-xylulose-5-phosphate synthase -0.211 0.305 0.489 0.635
1,4-alpha-glucan branching enzyme -0.230 0.296 0.438 0.635
1,4-beta-mannosyl-N-acetylglucosamine phosphorylase -0.234 0.288 0.419 0.635
1,4-dihydroxy-2-naphthoate polyprenyltransferase -0.230 0.296 0.438 0.635
1,4-dihydroxy-2-naphthoyl-CoA synthase -0.230 0.296 0.438 0.635
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase -0.230 0.296 0.438 0.635
16S rRNA (cytidine(1402)-2’-O)-methyltransferase -0.242 0.294 0.412 0.635
16S rRNA (cytosine(1402)-N(4))-methyltransferase -0.230 0.296 0.438 0.635
16S rRNA (guanine(527)-N(7))-methyltransferase -0.230 0.296 0.438 0.635
16S rRNA (uracil(1498)-N(3))-methyltransferase -0.230 0.296 0.438 0.635
2’,3’-cyclic-nucleotide 2’-phosphodiesterase -0.285 0.310 0.360 0.635
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase -0.240 0.304 0.431 0.635
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -0.230 0.296 0.438 0.635
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -0.232 0.307 0.452 0.635
2-dehydro-3-deoxy-phosphogluconate aldolase -0.628 0.582 0.282 0.635
2-dehydro-3-deoxygluconokinase -0.577 0.590 0.329 0.635
2-dehydropantoate 2-reductase -0.220 0.329 0.504 0.635
2-iminoacetate synthase 18.519 3411.091 0.996 0.997
2-iminobutanoate/2-iminopropanoate deaminase -0.230 0.296 0.438 0.635
2-isopropylmalate synthase -0.100 1.127 0.930 0.968
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase -0.230 0.296 0.438 0.635
2-oxoacid oxidoreductase (ferredoxin) -0.241 0.306 0.433 0.635
2-oxoglutarate synthase -0.237 0.303 0.434 0.635
23S rRNA (adenine(2085)-N(6))-dimethyltransferase 0.141 0.367 0.701 0.790
23S rRNA (adenine(2503)-C(2))-methyltransferase -0.230 0.296 0.438 0.635
23S rRNA (cytosine(1962)-C(5))-methyltransferase -0.230 0.296 0.438 0.635
23S rRNA (pseudouridine(1915)-N(3))-methyltransferase -0.230 0.296 0.438 0.635
23S rRNA (uracil(1939)-C(5))-methyltransferase -0.230 0.296 0.438 0.635
23S rRNA pseudouridine(1911/1915/1917) synthase -0.230 0.296 0.438 0.635
23S rRNA pseudouridine(2605) synthase -0.230 0.296 0.438 0.635
23S rRNA pseudouridine(746) synthase -0.223 0.336 0.508 0.635
3’-nucleotidase -0.285 0.310 0.360 0.635
3’(2’),5’-bisphosphate nucleotidase -0.242 0.294 0.412 0.635
3-dehydroquinate dehydratase -0.230 0.296 0.438 0.635
3-dehydroquinate synthase -0.230 0.296 0.438 0.635
3-deoxy-8-phosphooctulonate synthase -0.230 0.296 0.438 0.635
3-deoxy-manno-octulosonate-8-phosphatase -0.232 0.301 0.441 0.635
3-deoxy-manno-octulosonate cytidylyltransferase -0.243 0.292 0.407 0.635
3-hydroxyacyl-[acyl-carrier-protein] dehydratase -0.331 0.309 0.285 0.635
3-isopropylmalate dehydratase -0.100 1.127 0.930 0.968
3-isopropylmalate dehydrogenase -0.100 1.127 0.930 0.968
3-methyl-2-oxobutanoate hydroxymethyltransferase -0.213 0.298 0.477 0.635
3-oxoacyl-[acyl-carrier-protein] reductase -0.342 0.306 0.265 0.635
3-phosphoshikimate 1-carboxyvinyltransferase -0.230 0.296 0.438 0.635
3,4-dihydroxy-2-butanone-4-phosphate synthase -0.226 0.295 0.445 0.635
4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol kinase -0.230 0.296 0.438 0.635
4-alpha-glucanotransferase -0.230 0.296 0.438 0.635
4-carboxymuconolactone decarboxylase -0.135 0.612 0.825 0.905
4-hydroxy-3-methylbut-2-enyl diphosphate reductase -0.230 0.296 0.438 0.635
4-hydroxy-tetrahydrodipicolinate reductase -0.230 0.296 0.438 0.635
4-hydroxy-tetrahydrodipicolinate synthase -0.230 0.296 0.438 0.635
4-hydroxythreonine-4-phosphate dehydrogenase -0.230 0.296 0.438 0.635
4-O-beta-D-mannosyl-D-glucose phosphorylase -0.588 0.587 0.318 0.635
4-phosphoerythronate dehydrogenase -0.754 1.120 0.502 0.635
5’-nucleotidase -0.225 0.298 0.452 0.635
5’ to 3’ exodeoxyribonuclease (nucleoside 3’-phosphate-forming) -0.789 0.881 0.372 0.635
5-(carboxyamino)imidazole ribonucleotide mutase -0.230 0.296 0.438 0.635
5-amino-6-(5-phosphoribosylamino)uracil reductase -0.230 0.296 0.438 0.635
5-dehydro-4-deoxy-D-glucuronate isomerase -0.676 0.652 0.302 0.635
5-formyltetrahydrofolate cyclo-ligase -0.230 0.296 0.438 0.635
6-carboxytetrahydropterin synthase -0.395 0.451 0.383 0.635
6-phosphofructokinase -0.230 0.296 0.438 0.635
6-pyruvoyltetrahydropterin synthase -0.395 0.451 0.383 0.635
6,7-dimethyl-8-ribityllumazine synthase -0.230 0.296 0.438 0.635
7-cyano-7-deazaguanine synthase -0.230 0.296 0.438 0.635
8-amino-7-oxononanoate synthase -0.754 1.120 0.502 0.635
8-oxo-dGTP diphosphatase -0.128 0.324 0.693 0.790
Acetate–CoA ligase -0.203 0.301 0.500 0.635
Acetate kinase -0.230 0.296 0.438 0.635
Acetolactate synthase -0.548 0.584 0.350 0.635
acetylglucosaminyltransferase -0.230 0.296 0.438 0.635
Acetylglutamate kinase -0.100 1.127 0.930 0.968
Acetylornithine deacetylase -0.100 1.127 0.930 0.968
Acetylornithine transaminase -0.100 1.127 0.930 0.968
Acid phosphatase -0.073 0.305 0.811 0.902
Aconitate hydratase -0.429 1.387 0.758 0.845
Acyl-[acyl-carrier-protein]–UDP-N-acetylglucosamine O-acyltransferase -0.230 0.296 0.438 0.635
Adenine phosphoribosyltransferase -0.230 0.296 0.438 0.635
Adenosylcobalamin/alpha-ribazole phosphatase -0.680 0.538 0.208 0.635
Adenosylcobinamide-GDP ribazoletransferase -0.680 0.538 0.208 0.635
Adenosylcobinamide-phosphate guanylyltransferase -0.680 0.538 0.208 0.635
Adenosylcobinamide kinase -0.680 0.538 0.208 0.635
Adenosylhomocysteine nucleosidase -0.230 0.296 0.438 0.635
Adenylate kinase -0.230 0.296 0.438 0.635
Adenylosuccinate lyase -0.230 0.296 0.438 0.635
Adenylosuccinate synthase -0.230 0.296 0.438 0.635
Adenylyl-sulfate kinase -0.754 1.120 0.502 0.635
Alanine–tRNA ligase -0.230 0.296 0.438 0.635
Alanine dehydrogenase -0.647 0.554 0.244 0.635
Alanine racemase -0.230 0.296 0.438 0.635
Aldose 1-epimerase -0.243 0.306 0.429 0.635
Alkaline phosphatase -0.400 0.466 0.392 0.635
All-trans-octaprenyl-diphosphate synthase -0.230 0.296 0.438 0.635
All-trans-retinol 13,14-reductase -0.696 0.523 0.185 0.635
Alpha-amylase -0.248 0.296 0.404 0.635
Alpha-D-xyloside xylohydrolase -0.603 0.561 0.284 0.635
Alpha-galactosidase -0.168 0.287 0.561 0.685
Alpha-glucosidase -0.117 0.305 0.702 0.790
Alpha-glucuronidase -0.788 0.881 0.373 0.635
Alpha-L-fucosidase -0.244 0.296 0.412 0.635
Alpha-L-rhamnosidase -0.319 0.983 0.746 0.837
Alpha-N-acetylglucosaminidase -0.855 0.801 0.287 0.635
Altronate dehydratase -0.676 0.652 0.302 0.635
Amidophosphoribosyltransferase -0.219 0.308 0.477 0.635
Aminoacyl-tRNA hydrolase -0.230 0.296 0.438 0.635
Aminodeoxychorismate lyase -0.158 0.328 0.632 0.736
Aminodeoxychorismate synthase -0.158 0.328 0.632 0.736
Aminomethyltransferase -0.190 0.321 0.556 0.680
AMP nucleosidase -0.754 1.120 0.502 0.635
Anthranilate phosphoribosyltransferase -0.089 1.133 0.938 0.969
Anthranilate synthase -0.163 0.338 0.630 0.736
Arabinan endo-1,5-alpha-L-arabinosidase -0.573 0.507 0.260 0.635
Arabinogalactan endo-beta-1,4-galactanase -0.483 0.529 0.363 0.635
Arabinose-5-phosphate isomerase -0.230 0.296 0.438 0.635
Arginine–tRNA ligase -0.230 0.296 0.438 0.635
Arginine decarboxylase -0.230 0.296 0.438 0.635
Argininosuccinate lyase -0.100 1.127 0.930 0.968
Argininosuccinate synthase -0.100 1.127 0.930 0.968
Arylsulfatase -0.131 0.339 0.701 0.790
Asparaginase -0.260 0.336 0.441 0.635
Asparagine–tRNA ligase -0.230 0.296 0.438 0.635
Asparagine synthase (glutamine-hydrolyzing) 18.519 3411.091 0.996 0.997
Aspartate–ammonia ligase -0.213 0.293 0.468 0.635
Aspartate–tRNA ligase -0.230 0.296 0.438 0.635
Aspartate-semialdehyde dehydrogenase -0.230 0.296 0.438 0.635
Aspartate 1-decarboxylase -0.213 0.298 0.477 0.635
Aspartate ammonia-lyase -0.259 0.322 0.423 0.635
Aspartate carbamoyltransferase -0.230 0.296 0.438 0.635
Aspartate kinase -0.249 0.296 0.402 0.635
Aspartate transaminase -0.235 0.289 0.416 0.635
Aspartyl aminopeptidase 18.519 3411.091 0.996 0.997
ATP phosphoribosyltransferase -0.100 1.127 0.930 0.968
Bacterial non-heme ferritin -0.219 0.301 0.468 0.635
Beta-1,4-mannooligosaccharide phosphorylase -0.234 0.288 0.419 0.635
Beta-fructofuranosidase -0.496 0.487 0.311 0.635
Beta-galactosidase -0.246 0.296 0.408 0.635
Beta-glucosidase -0.399 0.427 0.352 0.635
Beta-ketoacyl-[acyl-carrier-protein] synthase I -0.741 0.488 0.131 0.635
Beta-ketoacyl-[acyl-carrier-protein] synthase II -0.230 0.296 0.438 0.635
Beta-ketoacyl-[acyl-carrier-protein] synthase III -0.223 0.335 0.506 0.635
Beta-lactamase -0.298 0.574 0.604 0.718
Beta-N-acetylhexosaminidase -0.212 0.270 0.432 0.635
Biotin–[acetyl-CoA-carboxylase] ligase -0.230 0.296 0.438 0.635
Bleomycin hydrolase -0.224 0.296 0.452 0.635
Branched-chain-amino-acid transaminase -0.230 0.296 0.438 0.635
Butyrate kinase -0.147 0.329 0.655 0.755
C-terminal processing peptidase -0.230 0.296 0.438 0.635
Cadmium-exporting ATPase -0.201 0.284 0.481 0.635
Calcium-transporting ATPase -0.156 0.300 0.605 0.718
Carbamoyl-phosphate synthase (glutamine-hydrolyzing) -0.232 0.298 0.439 0.635
Carbonate dehydratase -0.169 0.333 0.614 0.727
Carboxynorspermidine decarboxylase -0.230 0.296 0.438 0.635
CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase -0.227 0.517 0.662 0.761
CDP-diacylglycerol–serine O-phosphatidyltransferase -0.230 0.296 0.438 0.635
CDP-glycerol glycerophosphotransferase 0.092 1.404 0.948 0.979
Cellobiose phosphorylase 0.154 1.349 0.909 0.968
Cellulase 18.519 3411.091 0.996 0.997
Choline-phosphate cytidylyltransferase -0.221 0.572 0.699 0.790
Chondroitin-sulfate-ABC endolyase -0.677 0.652 0.301 0.635
Chondroitin-sulfate-ABC exolyase -0.677 0.652 0.301 0.635
Chorismate mutase -0.230 0.296 0.438 0.635
Chorismate synthase -0.230 0.296 0.438 0.635
Citrate (Si)-synthase 18.519 3411.091 0.996 0.997
Citrate CoA-transferase 2.304 1.989 0.248 0.635
Citrate lyase holo-[acyl-carrier protein] synthase 2.304 1.989 0.248 0.635
Citryl-CoA lyase 2.304 1.989 0.248 0.635
Cob(I)yrinic acid a,c-diamide adenosyltransferase -0.256 0.335 0.446 0.635
Cobaltochelatase -0.341 0.419 0.416 0.635
Coproporphyrinogen dehydrogenase -0.227 0.294 0.441 0.635
Creatininase -2.232 1.933 0.250 0.635
Crossover junction endodeoxyribonuclease -0.230 0.296 0.438 0.635
CTP synthase (glutamine hydrolyzing) -0.230 0.296 0.438 0.635
Cu(2+)-exporting ATPase -0.224 0.285 0.434 0.635
Cyclic pyranopterin phosphate synthase -0.137 0.613 0.823 0.905
Cystathionine beta-lyase -0.267 0.319 0.403 0.635
Cysteine–tRNA ligase -0.230 0.296 0.438 0.635
Cysteine desulfurase -0.230 0.296 0.438 0.635
Cysteine synthase -0.260 0.313 0.407 0.635
Cytidine deaminase -0.230 0.296 0.438 0.635
D-Ala-D-Ala dipeptidase -0.199 0.288 0.490 0.635
D-alanine–D-alanine ligase -0.230 0.296 0.438 0.635
D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase 18.519 3411.091 0.996 0.997
D-glycero-alpha-D-manno-heptose-7-phosphate kinase 18.519 3411.091 0.996 0.997
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase 18.519 3411.091 0.996 0.997
D-lactate dehydrogenase -0.088 0.288 0.760 0.846
D-sedoheptulose 7-phosphate isomerase 18.519 3411.091 0.996 0.997
dCMP deaminase -0.230 0.296 0.438 0.635
Demethylmenaquinone methyltransferase -0.230 0.296 0.438 0.635
Deoxyribose-phosphate aldolase -0.230 0.296 0.438 0.635
Dephospho-CoA kinase -0.228 0.308 0.459 0.635
Dextranase -0.282 0.509 0.580 0.704
dGTPase -0.230 0.296 0.438 0.635
Diamine N-acetyltransferase -0.230 0.296 0.438 0.635
Diaminohydroxyphosphoribosylaminopyrimidine deaminase -0.230 0.296 0.438 0.635
Diaminopimelate decarboxylase -0.274 0.307 0.374 0.635
Diaminopimelate dehydrogenase -0.228 0.293 0.436 0.635
Diaminopimelate epimerase -0.394 0.395 0.320 0.635
Dihydrofolate reductase -0.201 0.284 0.481 0.635
Dihydrofolate synthase -0.230 0.296 0.438 0.635
Dihydrolipoyl dehydrogenase -0.190 0.321 0.556 0.680
Dihydroneopterin aldolase -0.230 0.296 0.438 0.635
Dihydroorotase -0.220 0.308 0.477 0.635
Dihydroorotate dehydrogenase (NAD(+)) -0.230 0.296 0.438 0.635
Dihydropteroate synthase -0.230 0.296 0.438 0.635
Dihydroxy-acid dehydratase -0.548 0.584 0.350 0.635
Dimethylallyltranstransferase -0.230 0.296 0.438 0.635
Dipeptidase E -0.619 0.514 0.230 0.635
Dipeptidyl-peptidase III -0.230 0.296 0.438 0.635
Dipeptidyl-peptidase IV -0.230 0.296 0.438 0.635
Diphosphate–fructose-6-phosphate 1-phosphotransferase -0.230 0.296 0.438 0.635
diphosphate specific) -0.230 0.296 0.438 0.635
DNA-(apurinic or apyrimidinic site) lyase -0.138 0.295 0.642 0.744
DNA-3-methyladenine glycosylase I -0.227 0.333 0.497 0.635
DNA-directed DNA polymerase -0.228 0.295 0.441 0.635
DNA-directed RNA polymerase -0.227 0.300 0.450 0.635
DNA (cytosine-5-)-methyltransferase -0.244 0.306 0.427 0.635
DNA helicase -0.238 0.300 0.428 0.635
DNA ligase (NAD(+)) -0.230 0.296 0.438 0.635
DNA topoisomerase -0.294 0.331 0.376 0.635
DNA topoisomerase (ATP-hydrolyzing) -0.230 0.296 0.438 0.635
Dolichyl-phosphate beta-D-mannosyltransferase -0.230 0.296 0.438 0.635
dTDP-4-dehydrorhamnose 3,5-epimerase -0.230 0.296 0.438 0.635
dTDP-4-dehydrorhamnose reductase -0.230 0.296 0.438 0.635
dTDP-glucose 4,6-dehydratase -0.230 0.296 0.438 0.635
dUTP diphosphatase -0.230 0.296 0.438 0.635
Endo-1,4-beta-xylanase 18.519 3411.091 0.996 0.997
Endopeptidase Clp -0.230 0.296 0.438 0.635
Endopeptidase La -0.220 0.308 0.477 0.635
Enoyl-[acyl-carrier-protein] reductase (NADH) -0.219 0.301 0.468 0.635
Enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) -0.219 0.301 0.468 0.635
Epoxyqueuosine reductase -0.230 0.296 0.438 0.635
Exo-1,4-beta-D-glucosaminidase -2.232 1.933 0.250 0.635
Exo-alpha-sialidase -0.234 0.288 0.419 0.635
Exodeoxyribonuclease III -0.138 0.295 0.642 0.744
Exodeoxyribonuclease V -0.754 1.120 0.502 0.635
Exodeoxyribonuclease VII -0.230 0.296 0.438 0.635
FAD synthetase -0.230 0.296 0.438 0.635
FMN reductase (NAD(P)H) -0.230 0.296 0.438 0.635
Formate–tetrahydrofolate ligase -0.263 0.312 0.401 0.635
Formate C-acetyltransferase -0.215 0.295 0.468 0.635
Formimidoyltetrahydrofolate cyclodeaminase -0.162 0.333 0.626 0.734
Formyltetrahydrofolate deformylase -0.789 0.881 0.372 0.635
Fructan beta-fructosidase -0.268 0.313 0.394 0.635
Fructokinase -0.239 0.302 0.431 0.635
Fructose-bisphosphatase -0.230 0.296 0.438 0.635
Fructose-bisphosphate aldolase -0.230 0.296 0.438 0.635
Fructuronate reductase -0.677 0.652 0.301 0.635
Fumarate hydratase -0.228 0.345 0.510 0.635
Fumarate reductase (quinol) -0.230 0.296 0.438 0.635
Galactokinase -0.224 0.269 0.406 0.635
Galactoside O-acetyltransferase -0.062 0.367 0.865 0.945
GDP-L-fucose synthase -0.230 0.296 0.438 0.635
GDP-mannose 4,6-dehydratase -0.230 0.296 0.438 0.635
Geranylgeranyl diphosphate synthase -0.230 0.296 0.438 0.635
Gingipain R -0.001 1.049 0.999 0.999
Glucokinase -0.268 0.292 0.361 0.635
Gluconate 5-dehydrogenase -0.542 0.584 0.355 0.635
Glucosamine-6-phosphate deaminase -0.226 0.290 0.438 0.635
Glucose-1-phosphatase -0.072 0.305 0.815 0.904
Glucose-1-phosphate thymidylyltransferase -0.230 0.296 0.438 0.635
Glucose-6-phosphate isomerase -0.230 0.296 0.438 0.635
Glucosylceramidase 0.151 1.352 0.911 0.968
Glucuronate isomerase -0.839 0.582 0.151 0.635
Glutamate–ammonia ligase -0.204 0.294 0.489 0.635
Glutamate–tRNA ligase -0.230 0.296 0.438 0.635
Glutamate-5-semialdehyde dehydrogenase 18.519 3411.091 0.996 0.997
Glutamate 5-kinase 18.519 3411.091 0.996 0.997
Glutamate dehydrogenase (NADP(+)) -0.154 0.290 0.596 0.718
Glutamate formimidoyltransferase -0.162 0.333 0.626 0.734
Glutamate racemase -0.230 0.296 0.438 0.635
Glutamate synthase (NADH) -0.323 0.318 0.311 0.635
Glutamate synthase (NADPH) -0.323 0.318 0.311 0.635
Glutamine–fructose-6-phosphate transaminase (isomerizing) -0.243 0.311 0.436 0.635
Glutamine–tRNA ligase -0.230 0.296 0.438 0.635
Glutathione peroxidase -0.203 0.301 0.502 0.635
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) -0.230 0.296 0.438 0.635
Glycerate 3-kinase -0.206 0.323 0.524 0.647
Glycerate dehydrogenase -0.230 0.296 0.438 0.635
Glycerol-3-phosphate cytidylyltransferase 0.358 0.550 0.516 0.641
Glycerol-3-phosphate dehydrogenase -0.228 0.331 0.492 0.635
Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) -0.230 0.296 0.438 0.635
Glycerol kinase -0.075 0.341 0.826 0.905
Glycerophosphodiester phosphodiesterase -0.647 0.496 0.194 0.635
Glycine–tRNA ligase -0.230 0.296 0.438 0.635
Glycine C-acetyltransferase -0.323 0.372 0.387 0.635
Glycine dehydrogenase (aminomethyl-transferring) -0.190 0.321 0.556 0.680
Glycine hydroxymethyltransferase -0.230 0.296 0.438 0.635
Glycogen phosphorylase -0.230 0.296 0.438 0.635
GMP synthase (glutamine-hydrolyzing) -0.230 0.296 0.438 0.635
GTP cyclohydrolase I -0.201 0.284 0.481 0.635
GTP cyclohydrolase II -0.231 0.296 0.437 0.635
GTP diphosphokinase -0.231 0.299 0.439 0.635
Guanylate kinase -0.230 0.296 0.438 0.635
H(+)-transporting two-sector ATPase -0.237 0.295 0.423 0.635
Hippurate hydrolase -1.546 2.070 0.456 0.635
Histidine–tRNA ligase -0.230 0.296 0.438 0.635
Histidine ammonia-lyase -0.162 0.333 0.626 0.734
Histidine kinase -0.226 0.296 0.445 0.635
Histidinol-phosphatase -0.100 1.127 0.930 0.968
Histidinol-phosphate transaminase -0.159 0.284 0.576 0.702
Histidinol dehydrogenase -0.100 1.127 0.930 0.968
Homoserine dehydrogenase -0.274 0.307 0.374 0.635
Homoserine O-succinyltransferase -0.274 0.307 0.374 0.635
Hyaluronoglucosaminidase -0.247 0.317 0.437 0.635
Hydroxylamine reductase -0.206 0.301 0.494 0.635
Hydroxymethylpyrimidine kinase -0.134 0.312 0.669 0.765
Hypoxanthine phosphoribosyltransferase -0.230 0.296 0.438 0.635
Imidazoleglycerol-phosphate dehydratase -0.100 1.127 0.930 0.968
Imidazolonepropionase -0.162 0.333 0.626 0.734
IMP cyclohydrolase -0.230 0.296 0.438 0.635
IMP dehydrogenase -0.230 0.296 0.438 0.635
Indole-3-glycerol-phosphate synthase -0.376 0.442 0.397 0.635
Inorganic diphosphatase -0.240 0.317 0.450 0.635
Inositol-3-phosphate synthase -0.144 0.334 0.667 0.765
Iron-chelate-transporting ATPase -0.230 0.296 0.438 0.635
Isochorismate synthase -0.230 0.296 0.438 0.635
Isocitrate dehydrogenase (NADP(+)) -0.429 1.387 0.758 0.845
Isoleucine–tRNA ligase -0.220 0.308 0.477 0.635
isomerase -0.100 1.127 0.930 0.968
Kdo(2)-lipid IV(A) lauroyltransferase -0.230 0.296 0.438 0.635
Ketol-acid reductoisomerase (NADP(+)) -0.548 0.584 0.350 0.635
L-arabinose isomerase -0.670 0.642 0.298 0.635
L-aspartate oxidase -0.172 0.328 0.602 0.718
L-rhamnose isomerase -0.810 0.830 0.330 0.635
L-rhamnose mutarotase -0.846 0.965 0.382 0.635
L-ribulose-5-phosphate 4-epimerase -0.670 0.642 0.298 0.635
L-serine ammonia-lyase -0.230 0.296 0.438 0.635
L-threonine aldolase -0.170 0.761 0.824 0.905
L-threonylcarbamoyladenylate synthase -0.230 0.296 0.438 0.635
Lactoylglutathione lyase -1.045 0.919 0.257 0.635
Leucine–tRNA ligase -0.222 0.299 0.458 0.635
Leucyltransferase 0.056 0.493 0.910 0.968
Levanase -0.223 0.321 0.489 0.635
Lipid-A-disaccharide synthase -0.230 0.296 0.438 0.635
Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -0.230 0.296 0.438 0.635
Lipoate–protein ligase -0.717 0.722 0.322 0.635
Lipoyl synthase -0.230 0.317 0.469 0.635
LL-diaminopimelate aminotransferase -0.394 0.395 0.320 0.635
Long-chain-fatty-acid–CoA ligase -0.247 0.302 0.414 0.635
Lysine–tRNA ligase -0.230 0.296 0.438 0.635
Lysozyme 0.038 0.447 0.932 0.968
Malate dehydrogenase -0.230 0.296 0.438 0.635
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) -0.230 0.296 0.438 0.635
Maltose alpha-D-glucosyltransferase -0.629 0.781 0.422 0.635
Maltose O-acetyltransferase -0.230 0.328 0.484 0.635
Mannan endo-1,4-beta-mannosidase -0.329 0.354 0.354 0.635
Mannonate dehydratase -0.692 0.616 0.263 0.635
Mannose-1-phosphate guanylyltransferase -0.230 0.296 0.438 0.635
Mannose-6-phosphate isomerase -0.230 0.296 0.438 0.635
Methenyltetrahydrofolate cyclohydrolase -0.230 0.296 0.438 0.635
Methionine–tRNA ligase -0.230 0.296 0.438 0.635
Methionine adenosyltransferase -0.243 0.292 0.407 0.635
Methionine synthase -0.206 0.312 0.510 0.635
Methionyl-tRNA formyltransferase -0.230 0.296 0.438 0.635
Methionyl aminopeptidase -0.224 0.289 0.440 0.635
Methylaspartate ammonia-lyase -0.221 0.572 0.699 0.790
Methylaspartate mutase -0.221 0.572 0.699 0.790
Methylated-DNA–[protein]-cysteine S-methyltransferase -0.230 0.296 0.438 0.635
Methylenetetrahydrofolate dehydrogenase (NADP(+)) -0.230 0.296 0.438 0.635
Methylenetetrahydrofolate reductase (NAD(P)H) -0.264 0.307 0.391 0.635
Methylmalonyl-CoA mutase -0.246 0.310 0.427 0.635
N-acetyl-gamma-glutamyl-phosphate reductase -0.100 1.127 0.930 0.968
N-acetylmuramic acid 6-phosphate etherase -0.747 0.519 0.152 0.635
N-acetylmuramoyl-L-alanine amidase -0.285 0.315 0.367 0.635
N-acetylneuraminate lyase -0.206 0.295 0.486 0.635
N-acetylneuraminate synthase -2.232 1.933 0.250 0.635
N-acylglucosamine 2-epimerase -0.240 0.289 0.409 0.635
N-acylneuraminate cytidylyltransferase -2.232 1.933 0.250 0.635
N-carbamoylputrescine amidase -0.230 0.296 0.438 0.635
N-succinylornithine carbamoyltransferase -0.100 1.127 0.930 0.968
N(6)-L-threonylcarbamoyladenine synthase -0.230 0.296 0.438 0.635
NAD(+) diphosphatase -0.230 0.296 0.438 0.635
NAD(+) kinase -0.230 0.296 0.438 0.635
NAD(+) synthase (glutamine-hydrolyzing) -0.230 0.296 0.438 0.635
NAD(P)H-hydrate epimerase -0.230 0.296 0.438 0.635
NADH dehydrogenase -0.211 0.290 0.469 0.635
NADH:ubiquinone reductase (H(+)-translocating) -0.230 0.296 0.438 0.635
Nicotinamidase -0.097 0.315 0.757 0.845
Nicotinamide-nucleotide amidase -0.230 0.296 0.438 0.635
Nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase -0.680 0.538 0.208 0.635
Nicotinate-nucleotide adenylyltransferase -0.230 0.296 0.438 0.635
Nicotinate-nucleotide diphosphorylase (carboxylating) -0.172 0.328 0.602 0.718
Nicotinate phosphoribosyltransferase -0.231 0.296 0.438 0.635
Nitric-oxide reductase (cytochrome c) 0.054 0.493 0.913 0.968
Nitrite reductase (cytochrome; ammonia-forming) -0.217 0.299 0.469 0.635
Nitrous-oxide reductase -0.319 0.983 0.746 0.837
Non-reducing end alpha-L-arabinofuranosidase -0.691 0.615 0.263 0.635
Non-specific serine/threonine protein kinase -0.044 0.314 0.889 0.968
Nucleoside-diphosphate kinase -0.754 1.120 0.502 0.635
O-acetylhomoserine aminocarboxypropyltransferase -0.208 0.306 0.498 0.635
o-succinylbenzoate–CoA ligase -0.219 0.301 0.468 0.635
Oligonucleotidase -0.230 0.296 0.438 0.635
Orotate phosphoribosyltransferase -0.230 0.296 0.438 0.635
Orotidine-5’-phosphate decarboxylase -0.230 0.296 0.438 0.635
Pantetheine-phosphate adenylyltransferase -0.230 0.296 0.438 0.635
Pantoate–beta-alanine ligase (AMP-forming) -0.213 0.298 0.477 0.635
Pantothenate kinase -0.230 0.296 0.438 0.635
Pectinesterase -0.674 0.651 0.302 0.635
Peptide-methionine (R)-S-oxide reductase -0.230 0.296 0.438 0.635
Peptide-methionine (S)-S-oxide reductase -0.230 0.296 0.438 0.635
Peptide chain release factor N(5)-glutamine methyltransferase -0.230 0.296 0.438 0.635
Peptide deformylase -0.230 0.296 0.438 0.635
Peptidyl-dipeptidase Dcp -0.233 0.311 0.453 0.635
Peptidylprolyl isomerase -0.215 0.294 0.466 0.635
Peroxiredoxin -0.236 0.295 0.424 0.635
Phenylalanine–tRNA ligase -0.230 0.296 0.438 0.635
Phosphate acetyltransferase -0.230 0.296 0.438 0.635
Phosphate butyryltransferase -0.147 0.329 0.655 0.755
Phosphatidate cytidylyltransferase -0.230 0.296 0.438 0.635
Phosphatidylglycerophosphatase -0.015 0.569 0.979 0.997
Phosphatidylserine decarboxylase -0.230 0.296 0.438 0.635
Phospho-N-acetylmuramoyl-pentapeptide-transferase -0.230 0.296 0.438 0.635
Phosphoadenylyl-sulfate reductase (thioredoxin) 18.519 3411.091 0.996 0.997
Phosphoenolpyruvate carboxykinase (ATP) -0.230 0.296 0.438 0.635
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) -0.230 0.296 0.438 0.635
Phosphoglycerate dehydrogenase -0.228 0.293 0.436 0.635
Phosphoglycerate kinase -0.230 0.296 0.438 0.635
Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) 0.038 0.480 0.937 0.969
Phosphoglycerate mutase (2,3-diphosphoglycerate-independent) -0.291 0.314 0.356 0.635
Phosphoglycolate phosphatase -0.223 0.280 0.427 0.635
Phosphomannomutase -0.230 0.296 0.438 0.635
Phosphomethylpyrimidine kinase -0.134 0.312 0.669 0.765
Phosphomethylpyrimidine synthase 0.014 0.383 0.970 0.997
Phosphopantothenate–cysteine ligase -0.213 0.298 0.477 0.635
Phosphopantothenoylcysteine decarboxylase -0.213 0.298 0.477 0.635
Phosphopyruvate hydratase -0.230 0.296 0.438 0.635
Phosphoribosyl-AMP cyclohydrolase -0.100 1.127 0.930 0.968
Phosphoribosyl-ATP diphosphatase -0.100 1.127 0.930 0.968
Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase -0.230 0.296 0.438 0.635
Phosphoribosylamine–glycine ligase -0.230 0.296 0.438 0.635
Phosphoribosylaminoimidazolecarboxamide formyltransferase -0.230 0.296 0.438 0.635
Phosphoribosylaminoimidazolesuccinocarboxamide synthase -0.230 0.296 0.438 0.635
Phosphoribosylanthranilate isomerase -0.219 0.301 0.468 0.635
Phosphoribosylformylglycinamidine cyclo-ligase -0.230 0.296 0.438 0.635
Phosphoribosylformylglycinamidine synthase -0.220 0.308 0.477 0.635
Phosphoribosylglycinamide formyltransferase -0.219 0.308 0.477 0.635
Phosphoserine phosphatase -0.237 0.319 0.459 0.635
Phosphoserine transaminase -0.228 0.293 0.436 0.635
Polar-amino-acid-transporting ATPase -2.168 1.874 0.249 0.635
Polynucleotide adenylyltransferase -0.754 1.120 0.502 0.635
Polyribonucleotide nucleotidyltransferase -0.230 0.296 0.438 0.635
Potassium-transporting ATPase 2.304 1.989 0.248 0.635
Prephenate dehydratase -0.644 0.452 0.157 0.635
PreQ(1) synthase -0.230 0.296 0.438 0.635
Proline–tRNA ligase -0.230 0.296 0.438 0.635
Prolyl aminopeptidase 18.519 3411.091 0.996 0.997
Prolyl oligopeptidase -0.210 0.327 0.521 0.645
Protein-disulfide reductase -0.230 0.296 0.438 0.635
Protein-L-isoaspartate(D-aspartate) O-methyltransferase -0.137 0.613 0.823 0.905
Protein-tyrosine-phosphatase -0.237 0.301 0.432 0.635
Protoporphyrinogen oxidase -0.232 0.293 0.430 0.635
Pullulanase -0.252 0.318 0.429 0.635
Purine-nucleoside phosphorylase -0.230 0.296 0.438 0.635
Pyridoxal 5’-phosphate synthase (glutamine hydrolyzing) -0.219 0.301 0.468 0.635
Pyridoxal kinase -0.186 0.306 0.545 0.671
Pyridoxine 5’-phosphate synthase -0.754 1.120 0.502 0.635
Pyrroline-5-carboxylate reductase 0.139 1.250 0.912 0.968
Pyruvate carboxylase -0.230 0.296 0.438 0.635
Pyruvate kinase -0.230 0.296 0.438 0.635
Pyruvate synthase -0.230 0.296 0.438 0.635
Pyruvate, phosphate dikinase -0.230 0.296 0.438 0.635
Quinolinate synthase -0.172 0.328 0.602 0.718
Rhamnulokinase -0.810 0.830 0.330 0.635
Rhamnulose-1-phosphate aldolase -0.810 0.830 0.330 0.635
Riboflavin kinase -0.230 0.296 0.438 0.635
Riboflavin synthase -0.230 0.296 0.438 0.635
Ribonuclease H -0.230 0.296 0.438 0.635
Ribonuclease III -0.217 0.299 0.469 0.635
Ribonuclease P -0.230 0.296 0.438 0.635
Ribonuclease Z -0.230 0.296 0.438 0.635
Ribonucleoside-diphosphate reductase -0.160 0.292 0.584 0.707
Ribonucleoside-triphosphate reductase -0.230 0.296 0.438 0.635
Ribose-5-phosphate isomerase -0.230 0.296 0.438 0.635
Ribose-phosphate diphosphokinase -0.230 0.296 0.438 0.635
Ribulose-phosphate 3-epimerase -0.230 0.296 0.438 0.635
RNA-directed DNA polymerase 2.304 1.989 0.248 0.635
RNA helicase -0.230 0.296 0.438 0.635
RNA ligase (ATP) -2.232 1.933 0.250 0.635
S-adenosylmethionine:tRNA ribosyltransferase-isomerase -0.225 0.301 0.457 0.635
S-ribosylhomocysteine lyase -0.263 0.312 0.401 0.635
Saccharopine dehydrogenase (NAD(+), L-lysine-forming) -0.230 0.296 0.438 0.635
Selenocysteine lyase -0.230 0.296 0.438 0.635
Serine–tRNA ligase -0.230 0.296 0.438 0.635
Serine-type D-Ala-D-Ala carboxypeptidase -0.288 0.314 0.360 0.635
Serine O-acetyltransferase -0.157 0.290 0.590 0.713
Shikimate dehydrogenase -0.230 0.296 0.438 0.635
Shikimate kinase -0.230 0.296 0.438 0.635
Sialate O-acetylesterase -0.283 0.313 0.368 0.635
Signal peptidase I -0.223 0.297 0.456 0.635
Signal peptidase II -0.230 0.296 0.438 0.635
Site-specific DNA-methyltransferase (adenine-specific) -0.214 0.306 0.485 0.635
Starch synthase -0.230 0.296 0.438 0.635
Succinate–CoA ligase (ADP-forming) -0.173 0.329 0.600 0.718
Succinate dehydrogenase (quinone) -0.230 0.296 0.438 0.635
Sulfate adenylyltransferase -0.754 1.120 0.502 0.635
Superoxide dismutase -0.396 0.395 0.317 0.635
Superoxide reductase -0.166 0.321 0.605 0.718
synthase -0.230 0.296 0.438 0.635
Tagaturonate reductase -0.676 0.652 0.302 0.635
Tetraacyldisaccharide 4’-kinase -0.230 0.296 0.438 0.635
Tetrahydrofolate synthase -0.230 0.296 0.438 0.635
Thiamine-phosphate diphosphorylase -0.063 0.337 0.853 0.934
Thiamine-phosphate kinase -0.230 0.296 0.438 0.635
Thiamine diphosphokinase -0.198 0.307 0.519 0.643
Thiazole synthase 18.519 3411.091 0.996 0.997
Thioredoxin-disulfide reductase -0.230 0.296 0.438 0.635
Threonine–tRNA ligase -0.230 0.296 0.438 0.635
Threonine ammonia-lyase -0.378 0.462 0.414 0.635
Threonine synthase -0.606 0.561 0.282 0.635
Thymidine kinase -0.230 0.296 0.438 0.635
Thymidylate synthase -0.172 0.309 0.579 0.704
Thymidylate synthase (FAD) -0.625 0.575 0.278 0.635
Transketolase -0.234 0.306 0.446 0.635
Triose-phosphate isomerase -0.240 0.307 0.435 0.635
Tripeptide aminopeptidase -0.230 0.296 0.438 0.635
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase -0.230 0.296 0.438 0.635
tRNA-guanine(34) transglycosylase -0.230 0.296 0.438 0.635
tRNA (guanine(37)-N(1))-methyltransferase -0.230 0.296 0.438 0.635
tRNA (guanine(46)-N(7))-methyltransferase -0.230 0.296 0.438 0.635
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase -0.230 0.296 0.438 0.635
tRNA dimethylallyltransferase -0.230 0.296 0.438 0.635
tRNA pseudouridine(32) synthase -0.223 0.336 0.508 0.635
tRNA pseudouridine(38-40) synthase -0.230 0.296 0.438 0.635
tRNA pseudouridine(55) synthase -0.230 0.296 0.438 0.635
tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase -0.230 0.296 0.438 0.635
tRNA(adenine(34)) deaminase -0.230 0.296 0.438 0.635
tRNA(Ile)-lysidine synthetase -0.230 0.296 0.438 0.635
Tryptophan–tRNA ligase -0.230 0.296 0.438 0.635
Tryptophan synthase -0.229 0.301 0.447 0.635
Tryptophanase -0.221 0.572 0.699 0.790
Type I site-specific deoxyribonuclease -0.237 0.303 0.435 0.635
Type II site-specific deoxyribonuclease -0.343 0.461 0.459 0.635
Type III site-specific deoxyribonuclease -5.080 10.935 0.643 0.744
Tyrosine–tRNA ligase -0.230 0.296 0.438 0.635
UDP-2,3-diacylglucosamine diphosphatase -0.230 0.296 0.438 0.635
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -0.230 0.296 0.438 0.635
UDP-3-O-acyl-N-acetylglucosamine deacetylase -0.230 0.296 0.438 0.635
UDP-galactopyranose mutase -0.337 0.418 0.421 0.635
UDP-glucose 4-epimerase -0.241 0.294 0.412 0.635
UDP-glucose 6-dehydrogenase -0.219 0.308 0.477 0.635
UDP-glucuronate 4-epimerase -0.057 0.574 0.921 0.968
UDP-glucuronate decarboxylase -0.137 0.613 0.823 0.905
UDP-N-acetylglucosamine 1-carboxyvinyltransferase -0.230 0.296 0.438 0.635
UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -0.287 0.294 0.330 0.635
UDP-N-acetylmuramate–L-alanine ligase -0.230 0.296 0.438 0.635
UDP-N-acetylmuramate dehydrogenase -0.230 0.296 0.438 0.635
UDP-N-acetylmuramoyl-L-alanine–D-glutamate ligase -0.230 0.296 0.438 0.635
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase -0.230 0.296 0.438 0.635
UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase -0.230 0.296 0.438 0.635
UMP kinase -0.230 0.296 0.438 0.635
UMP/CMP kinase -0.230 0.296 0.438 0.635
Undecaprenyl-diphosphate phosphatase -0.274 0.301 0.364 0.635
Uracil-DNA glycosylase -0.204 0.307 0.507 0.635
Uracil phosphoribosyltransferase -0.230 0.296 0.438 0.635
Uridine kinase -0.230 0.296 0.438 0.635
Uridine phosphorylase -0.230 0.296 0.438 0.635
Urocanate hydratase -0.162 0.333 0.626 0.734
Uroporphyrinogen-III synthase -0.248 0.296 0.403 0.635
Valine–tRNA ligase -0.230 0.296 0.438 0.635
Xaa-Pro aminopeptidase -0.233 0.297 0.434 0.635
Xanthine phosphoribosyltransferase -0.156 0.300 0.605 0.718
XTP/dITP diphosphatase -0.230 0.296 0.438 0.635
Xylose isomerase -0.092 1.135 0.935 0.969
Xylulokinase -0.546 0.585 0.352 0.635
Zinc-exporting ATPase -0.201 0.284 0.481 0.635 
# merge with tb.ra for full results table
full.res <- left_join(tb.ra, results.out, by = "description")

write.csv(full.res, "output/picrust_ec_stratefied_prevo_data_results.csv", row.names = F)

Part 2 KO Data

descriptions <- readr::read_tsv("data/PICRUST/ko_pred_metagenome_unstrat_descrip.tsv")[,1:2] %>%
  distinct()

-- Column specification --------------------------------------------------------
cols(
  .default = col_double(),
  `function` = col_character(),
  description = col_character()
)
i Use `spec()` for the full column specifications.
colnames(descriptions) <- c("func", "description")

pi.dat <- readxl::read_xlsx("data/PICRUST-Stratified/KO_prevo.xlsx")
colnames(pi.dat) <- c("func",  colnames(pi.dat)[-c(1)])

# add descriptions to dataframe
pi.dat <- left_join(pi.dat, descriptions, by="func")
pi.dat <- pi.dat[,c(1,161,3:160)]

# aggregate descriptions to get 1 description per row - unique;y defined.
pi.dat <- pi.dat %>%
  group_by(description) %>%
  summarise(across(`X1.S37.Jun172016`:`X99.D01.S37.Jun232016`,.fns = mean))

# make long format
pi.dat <- pi.dat %>%
  pivot_longer(
    cols=`X1.S37.Jun172016`:`X99.D01.S37.Jun232016`,
    names_to = "ID",
    values_to = "Abundance"
  ) %>%
  mutate(
    ID = substr(ID, 2, 99)
  )

d <- as.data.frame(dat.16s)
mydata <- full_join(pi.dat, d)
Joining, by = "ID"
Warning in class(x) <- c(setdiff(subclass, tibble_class), tibble_class): Setting
class(x) to multiple strings ("tbl_df", "tbl", ...); result will no longer be an
S4 object
mydata <- mydata %>%
  mutate(
    ID.n = as.numeric(as.factor(ID)),
    description.n = as.numeric(as.factor(description))
  ) %>%
  group_by(description)%>%
  mutate(avgA = mean(Abundance))

Abundance

# Run on all descriptions
tb.ra1 <- mydata %>%
  group_by(description) %>%
  summarise(ng = n(),
            Overall.M = mean(Abundance),
            Overall.SE = sd(Abundance)/sqrt(ng))
tb.ra2m <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(M = mean(Abundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = M)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra2se <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(),SE = sd(Abundance)/sqrt(ng)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = SE)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra2var <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(), VAR = var(Abundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = VAR)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra2ng <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n()) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = ng)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra <- left_join(tb.ra1, tb.ra2m)
Joining, by = "description"
tb.ra <- cbind(tb.ra, tb.ra2se[,-1])
tb.ra <- cbind(tb.ra, tb.ra2var[,-1])
tb.ra <- cbind(tb.ra, tb.ra2ng[,-1]) 

colnames(tb.ra) <- c("description", "ng", "Overall Mean", "Overall SE", "Non-Tumor Mean", "Tumor Mean", "Non-Tumor SE", "Tumor SE","Non-Tumor Var", "Tumor Var", "Non-Tumor Ng", "Tumor Ng")
tb.ra <- tb.ra %>%
  arrange(desc(`Overall Mean`))
tb.ra <- tb.ra[, c("description", "Overall Mean", "Overall SE","Tumor Mean","Tumor Var", "Tumor SE","Tumor Ng", "Non-Tumor Mean","Non-Tumor Var", "Non-Tumor SE", "Non-Tumor Ng")]

# compute t-test
tb.ra <- tb.ra %>%
  mutate(
    SEpooled = sqrt(`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`),
    t = (`Tumor Mean` - `Non-Tumor Mean`)/(SEpooled),
    df = ((`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`)**2)/(((`Tumor Var`/`Tumor Ng`)**2)/(`Tumor Ng`-1) + ((`Non-Tumor Var`/`Non-Tumor Ng`)**2)/(`Non-Tumor Ng`-1)),
    p = pt(q = abs(t), df=df, lower.tail = F)*2,
    fdr_p = p.adjust(p, method="fdr")
  )


kable(tb.ra, format="html", digits=5, caption="Stratefied KO Data - Prevotella spp. (genus level only): Average Abundance of Each Description (sorted in descending order)") %>%
  kable_styling(full_width = T) %>%
  scroll_box(width = "100%", height="600px")
Stratefied KO Data - Prevotella spp. (genus level only): Average Abundance of Each Description (sorted in descending order)
description Overall Mean Overall SE Tumor Mean Tumor Var Tumor SE Tumor Ng Non-Tumor Mean Non-Tumor Var Non-Tumor SE Non-Tumor Ng SEpooled t df p fdr_p
APEX1; AP endonuclease 1 [EC:4.2.99.18] 8.24684 1.49040 8.93846 312.33990 2.19208 65 7.76344 381.07387 2.02425 93 2.98376 0.39381 145.890 0.69430 0.75849
ermC, ermA; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184] 8.24684 1.49040 8.93846 312.33990 2.19208 65 7.76344 381.07387 2.02425 93 2.98376 0.39381 145.890 0.69430 0.75849
mvpA, vapC; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-] 8.24684 1.49040 8.93846 312.33990 2.19208 65 7.76344 381.07387 2.02425 93 2.98376 0.39381 145.890 0.69430 0.75849
rpoE; RNA polymerase sigma-70 factor, ECF subfamily 7.26942 1.07943 6.13316 109.99455 1.30086 65 8.06359 236.09686 1.59332 93 2.05692 -0.93851 155.932 0.34943 0.59014
TC.FEV.OM; iron complex outermembrane recepter protein 6.70618 0.96552 5.84387 96.82517 1.22050 65 7.30886 183.11004 1.40318 93 1.85972 -0.78775 155.731 0.43204 0.59014
aqpZ; aquaporin Z 4.40823 0.75967 4.78846 85.01998 1.14368 65 4.14247 96.28587 1.01751 93 1.53079 0.42200 143.062 0.67366 0.75298
TC.AGCS; alanine or glycine:cation symporter, AGCS family 4.27772 0.73490 4.16431 56.82331 0.93499 65 4.35699 106.07639 1.06799 93 1.41944 -0.13574 155.641 0.89220 0.93415
ABCB-BAC; ATP-binding cassette, subfamily B, bacterial 3.96416 0.59975 3.31289 34.02772 0.72354 65 4.41935 72.80635 0.88480 93 1.14296 -0.96806 155.942 0.33451 0.59014
wbpO; UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.-] 3.93882 0.63902 3.76410 43.01987 0.81354 65 4.06093 80.13997 0.92829 93 1.23433 -0.24048 155.625 0.81028 0.85611
fklB; FKBP-type peptidyl-prolyl cis-trans isomerase FklB [EC:5.2.1.8] 3.59337 0.50939 3.13305 27.15857 0.64639 65 3.91509 50.81504 0.73919 93 0.98195 -0.79642 155.658 0.42700 0.59014
hlpA, ompH; outer membrane protein 3.54928 0.50849 3.07947 26.94100 0.64380 65 3.87764 50.70983 0.73842 93 0.97967 -0.81474 155.700 0.41647 0.59014
ABC-2.P; ABC-2 type transport system permease protein 3.53269 0.53036 3.00202 29.05643 0.66860 65 3.90360 55.29069 0.77105 93 1.02056 -0.88342 155.769 0.37837 0.59014
K07054; uncharacterized protein 3.47679 0.60965 3.37692 39.28930 0.77746 65 3.54659 72.87039 0.88519 93 1.17814 -0.14402 155.591 0.88567 0.92815
acm; lysozyme 3.41403 0.48975 3.00721 25.05267 0.62083 65 3.69837 47.04435 0.71123 93 0.94408 -0.73210 155.683 0.46521 0.59070
K07729; putative transcriptional regulator 3.30380 0.59987 3.20000 35.79792 0.74212 65 3.37634 72.10924 0.88055 93 1.15157 -0.15313 155.984 0.87849 0.92146
tonB; periplasmic protein TonB 2.99358 0.40215 2.67459 16.16316 0.49866 65 3.21654 32.23904 0.58878 93 0.77157 -0.70240 155.964 0.48348 0.60131
K08987; putative membrane protein 2.90633 0.50347 2.97231 31.53985 0.69658 65 2.86022 46.40068 0.70635 93 0.99205 0.11299 151.703 0.91019 0.94278
topB; DNA topoisomerase III [EC:5.99.1.2] 2.84302 0.47030 2.33538 21.14334 0.57034 65 3.19781 44.61939 0.69266 93 0.89725 -0.96119 155.975 0.33795 0.59014
cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 3.6.4.-] 2.78481 1.14192 1.63077 36.67404 0.75114 65 3.59140 324.48340 1.86790 93 2.01328 -0.97385 119.662 0.33210 0.59014
cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1] 2.78481 1.14192 1.63077 36.67404 0.75114 65 3.59140 324.48340 1.86790 93 2.01328 -0.97385 119.662 0.33210 0.59014
purU; formyltetrahydrofolate deformylase [EC:3.5.1.10] 2.78481 1.14192 1.63077 36.67404 0.75114 65 3.59140 324.48340 1.86790 93 2.01328 -0.97385 119.662 0.33210 0.59014
rhaT; L-rhamnose-H+ transport protein 2.78481 1.14192 1.63077 36.67404 0.75114 65 3.59140 324.48340 1.86790 93 2.01328 -0.97385 119.662 0.33210 0.59014
hupB; DNA-binding protein HU-beta 2.74369 0.39029 2.35098 15.08710 0.48178 65 3.01817 30.39124 0.57165 93 0.74759 -0.89245 155.984 0.37353 0.59014
ABC-2.A; ABC-2 type transport system ATP-binding protein 2.72351 0.40871 2.27724 15.33992 0.48580 65 3.03541 34.12899 0.60579 93 0.77652 -0.97637 155.771 0.33039 0.59014
lacZ; beta-galactosidase [EC:3.2.1.23] 2.71339 0.38345 2.36663 13.31689 0.45263 65 2.95575 30.23717 0.57020 93 0.72802 -0.80922 155.639 0.41963 0.59014
yjdF; putative membrane protein 2.67563 0.45828 2.54423 22.15793 0.58386 65 2.76747 41.19178 0.66552 93 0.88533 -0.25216 155.609 0.80125 0.85280
E3.4.21.102, prc, ctpA; carboxyl-terminal processing protease [EC:3.4.21.102] 2.66196 0.38137 2.30960 15.15431 0.48285 65 2.90823 28.52428 0.55382 93 0.73475 -0.81474 155.700 0.41647 0.59014
rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] 2.66196 0.38137 2.30960 15.15431 0.48285 65 2.90823 28.52428 0.55382 93 0.73475 -0.81474 155.700 0.41647 0.59014
THI4, THI1; cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60] 2.66076 0.50075 2.68308 31.18237 0.69262 65 2.64516 45.91750 0.70266 93 0.98664 0.03843 151.727 0.96940 0.97191
K07133; uncharacterized protein 2.60452 0.39305 2.23125 15.38840 0.48656 65 2.86541 30.78182 0.57531 93 0.75348 -0.84164 155.971 0.40128 0.59014
rpoD; RNA polymerase primary sigma factor 2.57584 0.37879 2.24085 14.91242 0.47898 65 2.80997 28.17801 0.55044 93 0.72967 -0.77998 155.725 0.43659 0.59014
pqqL; zinc protease [EC:3.4.24.-] 2.55596 0.37836 2.25989 15.85698 0.49392 65 2.76288 27.46255 0.54341 93 0.73434 -0.68496 154.863 0.49439 0.60550
HEXA_B; hexosaminidase [EC:3.2.1.52] 2.54759 0.33420 2.23600 10.03300 0.39288 65 2.76538 23.01861 0.49751 93 0.63393 -0.83507 155.560 0.40496 0.59014
ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3] 2.48114 0.36259 2.12976 12.59593 0.44021 65 2.72673 26.53775 0.53418 93 0.69220 -0.86243 155.978 0.38977 0.59014
lacA; galactoside O-acetyltransferase [EC:2.3.1.18] 2.44304 0.43807 2.35385 23.69096 0.60372 65 2.50538 35.25356 0.61569 93 0.86229 -0.17573 151.987 0.86074 0.90366
slo; thiol-activated cytolysin 2.43987 0.45834 2.22212 20.01331 0.55488 65 2.59207 42.66462 0.67732 93 0.87559 -0.42252 155.952 0.67323 0.75298
recG; ATP-dependent DNA helicase RecG [EC:3.6.4.12] 2.32095 0.34957 2.03586 13.80326 0.46082 65 2.52021 23.24809 0.49998 93 0.67995 -0.71232 154.464 0.47734 0.59693
K07025; putative hydrolase of the HAD superfamily 2.29437 0.34449 1.98928 11.80667 0.42619 65 2.50760 23.67258 0.50452 93 0.66044 -0.78480 155.975 0.43376 0.59014
ampG; MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG 2.28627 0.32814 2.00912 11.75174 0.42520 65 2.47998 20.76603 0.47254 93 0.63568 -0.74071 155.115 0.45999 0.59014
higA; HTH-type transcriptional regulator / antitoxin HigA 2.26076 0.38985 2.12154 15.89797 0.49455 65 2.35806 29.89637 0.56698 93 0.75236 -0.31438 155.693 0.75366 0.80734
yfbK; Ca-activated chloride channel homolog 2.22776 0.32567 1.91146 11.15516 0.41427 65 2.44883 20.71792 0.47199 93 0.62801 -0.85568 155.602 0.39349 0.59014
thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17] 2.21751 0.41729 2.23641 21.65211 0.57716 65 2.20430 31.88716 0.58555 93 0.82218 0.03905 151.729 0.96890 0.97191
gmuG; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78] 2.21519 0.61468 1.43077 14.98341 0.48012 65 2.76344 90.71381 0.98763 93 1.09815 -1.21356 130.171 0.22711 0.59014
lrp; Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein 2.19139 0.37266 2.13754 14.60691 0.47405 65 2.22903 27.27991 0.54160 93 0.71976 -0.12712 155.644 0.89901 0.94043
phoN; acid phosphatase (class A) [EC:3.1.3.2] 2.12922 0.31788 2.03846 10.04537 0.39312 65 2.19265 20.24728 0.46660 93 0.61013 -0.25272 155.985 0.80082 0.85280
ompX; outer membrane protein X 2.12579 0.34008 2.00673 13.00038 0.44722 65 2.20901 22.12241 0.48772 93 0.66173 -0.30568 154.618 0.76026 0.81366
chrA; chromate transporter 2.11580 0.30578 1.84870 9.84472 0.38918 65 2.30248 18.27595 0.44330 93 0.58989 -0.76926 155.598 0.44290 0.59014
FUCA; alpha-L-fucosidase [EC:3.2.1.51] 2.10873 0.30611 1.81154 8.68035 0.36544 65 2.31644 19.12088 0.45343 93 0.58236 -0.86698 155.825 0.38728 0.59014
gpx; glutathione peroxidase [EC:1.11.1.9] 2.08575 0.30445 1.84212 9.82200 0.38873 65 2.25603 18.08841 0.44102 93 0.58788 -0.70406 155.532 0.48245 0.60073
RETSAT; all-trans-retinol 13,14-reductase [EC:1.3.99.23] 2.06962 0.51497 1.30000 7.26781 0.33438 65 2.60753 65.73679 0.84074 93 0.90480 -1.44510 119.123 0.15105 0.59014
lacI, galR; LacI family transcriptional regulator 2.06038 0.29688 1.77812 8.80637 0.36808 65 2.25767 17.54288 0.43432 93 0.56931 -0.84233 155.961 0.40089 0.59014
TC.FEV.OM2, cirA, cfrA, hmuR; outer membrane receptor for ferrienterochelin and colicins 2.02785 0.30127 1.78005 10.52108 0.40232 65 2.20104 17.07975 0.42855 93 0.58781 -0.71619 153.845 0.47496 0.59524
ENDOG; endonuclease G, mitochondrial 1.99900 0.29592 1.76944 9.19099 0.37603 65 2.15944 17.15463 0.42949 93 0.57084 -0.68319 155.639 0.49550 0.60550
K07481; transposase, IS5 family 1.95886 0.41971 1.67231 17.61860 0.52063 65 2.15914 35.14184 0.61471 93 0.80556 -0.60434 155.964 0.54650 0.64313
E2.1.1.77, pcm; protein-L-isoaspartate(D-aspartate) O-methyltransferase [EC:2.1.1.77] 1.95570 0.59054 1.80000 15.53750 0.48892 65 2.06452 83.19144 0.94580 93 1.06469 -0.24844 133.985 0.80417 0.85291
moaA, CNX2; GTP 3’,8-cyclase [EC:4.1.99.22] 1.95570 0.59054 1.80000 15.53750 0.48892 65 2.06452 83.19144 0.94580 93 1.06469 -0.24844 133.985 0.80417 0.85291
UXS1, uxs; UDP-glucuronate decarboxylase [EC:4.1.1.35] 1.95570 0.59054 1.80000 15.53750 0.48892 65 2.06452 83.19144 0.94580 93 1.06469 -0.24844 133.985 0.80417 0.85291
capA, pgsA; gamma-polyglutamate biosynthesis protein CapA 1.95359 0.32110 1.82051 9.89523 0.39017 65 2.04659 20.89454 0.47400 93 0.61393 -0.36826 155.974 0.71318 0.77765
parA, soj; chromosome partitioning protein 1.95118 0.29226 1.62854 7.58564 0.34162 65 2.17668 17.62959 0.43539 93 0.55341 -0.99046 155.452 0.32349 0.59014
hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3] 1.93693 0.28025 1.66355 7.26802 0.33439 65 2.12800 16.03147 0.41519 93 0.53310 -0.87122 155.818 0.38497 0.59014
cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-] 1.89557 0.58745 1.20769 10.04603 0.39313 65 2.37634 85.49270 0.95879 93 1.03626 -1.12776 120.634 0.26166 0.59014
K08961; chondroitin-sulfate-ABC endolyase/exolyase [EC:4.2.2.20 4.2.2.21] 1.89557 0.58745 1.20769 10.04603 0.39313 65 2.37634 85.49270 0.95879 93 1.03626 -1.12776 120.634 0.26166 0.59014
uxuB; fructuronate reductase [EC:1.1.1.57] 1.89557 0.58745 1.20769 10.04603 0.39313 65 2.37634 85.49270 0.95879 93 1.03626 -1.12776 120.634 0.26166 0.59014
ccrM; modification methylase [EC:2.1.1.72] 1.87975 0.62564 1.56154 24.60553 0.61526 65 2.10215 88.30195 0.97441 93 1.15240 -0.46912 146.506 0.63968 0.72339
K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72] 1.87975 0.62564 1.56154 24.60553 0.61526 65 2.10215 88.30195 0.97441 93 1.15240 -0.46912 146.506 0.63968 0.72339
uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12] 1.86146 0.27463 1.59056 7.81293 0.34670 65 2.05080 14.81346 0.39910 93 0.52866 -0.87058 155.747 0.38533 0.59014
thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3] 1.84301 0.30387 1.77550 11.57318 0.42196 65 1.89020 16.84047 0.42554 93 0.59927 -0.19139 151.422 0.84848 0.89240
DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] 1.83761 0.27317 1.58082 6.34957 0.31255 65 2.01709 15.62402 0.40988 93 0.51545 -0.84638 154.840 0.39865 0.59014
bglX; beta-glucosidase [EC:3.2.1.21] 1.83754 0.37510 1.42643 10.79776 0.40758 65 2.12488 30.22281 0.57007 93 0.70078 -0.99666 152.728 0.32050 0.59014
uvrA; excinuclease ABC subunit A 1.81873 0.25528 1.59332 6.85442 0.32473 65 1.97627 12.74171 0.37015 93 0.49240 -0.77773 155.609 0.43791 0.59014
K08303; putative protease [EC:3.4.-.-] 1.81763 0.26441 1.58271 7.84342 0.34737 65 1.98183 13.32825 0.37857 93 0.51379 -0.77682 154.598 0.43845 0.59014
queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17] 1.81763 0.26441 1.58271 7.84342 0.34737 65 1.98183 13.32825 0.37857 93 0.51379 -0.77682 154.598 0.43845 0.59014
dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] 1.81698 0.25532 1.58960 6.86317 0.32494 65 1.97590 12.74006 0.37012 93 0.49252 -0.78433 155.598 0.43404 0.59014
recQ; ATP-dependent DNA helicase RecQ [EC:3.6.4.12] 1.80677 0.25605 1.55523 6.82229 0.32397 65 1.98257 12.85513 0.37179 93 0.49314 -0.86659 155.707 0.38750 0.59014
relA; GTP pyrophosphokinase [EC:2.7.6.5] 1.79472 0.25899 1.55618 7.00416 0.32826 65 1.96144 13.14542 0.37596 93 0.49910 -0.81197 155.680 0.41805 0.59014
K07483; transposase 1.79114 0.42529 1.39077 15.30304 0.48521 65 2.07097 37.93100 0.63864 93 0.80205 -0.84807 154.746 0.39771 0.59014
manC, cpsB; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13] 1.77468 0.25424 1.53984 6.73493 0.32189 65 1.93882 12.67746 0.36921 93 0.48983 -0.81453 155.700 0.41658 0.59014
clsA_B; cardiolipin synthase A/B [EC:2.7.8.-] 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.59014
DPP4, CD26; dipeptidyl-peptidase 4 [EC:3.4.14.5] 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.59014
fusA, GFM, EFG; elongation factor G 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.59014
lolC_E; lipoprotein-releasing system permease protein 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.59014
lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129] 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.59014
miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75] 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.59014
mrcA; penicillin-binding protein 1A [EC:2.4.1.129 3.4.16.4] 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.59014
pepD; dipeptidase D [EC:3.4.13.-] 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.59014
purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.59014
rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66] 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.59014
surA; peptidyl-prolyl cis-trans isomerase SurA [EC:5.2.1.8] 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.59014
udk, UCK; uridine kinase [EC:2.7.1.48] 1.77464 0.25425 1.53973 6.73525 0.32190 65 1.93882 12.67746 0.36921 93 0.48983 -0.81474 155.700 0.41647 0.59014
pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9] 1.77289 0.25428 1.53602 6.74360 0.32210 65 1.93845 12.67577 0.36919 93 0.48995 -0.82138 155.690 0.41269 0.59014
dcp; peptidyl-dipeptidase Dcp [EC:3.4.15.5] 1.76264 0.26389 1.52647 7.76356 0.34560 65 1.92770 13.30841 0.37829 93 0.51239 -0.78305 154.723 0.43479 0.59014
exbB; biopolymer transport protein ExbB 1.75347 0.25311 1.52700 6.66960 0.32033 65 1.91175 12.57260 0.36768 93 0.48765 -0.78900 155.710 0.43131 0.59014
K06950; uncharacterized protein 1.75347 0.25311 1.52700 6.66960 0.32033 65 1.91175 12.57260 0.36768 93 0.48765 -0.78900 155.710 0.43131 0.59014
SIAE; sialate O-acetylesterase [EC:3.1.1.53] 1.74466 0.26559 1.46302 5.38439 0.28781 65 1.94151 15.17863 0.40399 93 0.49603 -0.96464 152.585 0.33625 0.59014
BLMH, pepC; bleomycin hydrolase [EC:3.4.22.40] 1.73339 0.24859 1.51056 6.42249 0.31434 65 1.88914 12.13470 0.36122 93 0.47884 -0.79062 155.725 0.43037 0.59014
K07095; uncharacterized protein 1.73291 0.26228 1.47879 7.10645 0.33065 65 1.91052 13.52636 0.38137 93 0.50475 -0.85533 155.771 0.39368 0.59014
ABC-2.TX; HlyD family secretion protein 1.72881 0.25380 1.48244 6.66557 0.32023 65 1.90100 12.65810 0.36893 93 0.48852 -0.85679 155.757 0.39288 0.59014
K09975; uncharacterized protein 1.71941 0.29950 1.54872 9.80744 0.38844 65 1.83871 17.32864 0.43166 93 0.58070 -0.49938 155.113 0.61822 0.70276
K07098; uncharacterized protein 1.71571 0.25360 1.48881 6.68619 0.32072 65 1.87430 12.62784 0.36849 93 0.48852 -0.78912 155.722 0.43124 0.59014
fur, zur, furB; Fur family transcriptional regulator, ferric uptake regulator 1.71370 0.25715 1.45516 6.76393 0.32258 65 1.89439 13.04342 0.37450 93 0.49428 -0.88862 155.842 0.37558 0.59014
asnC; Lrp/AsnC family transcriptional regulator, regulator for asnA, asnC and gidA 1.70938 0.25260 1.47342 6.59059 0.31842 65 1.87430 12.55290 0.36739 93 0.48618 -0.82456 155.775 0.41088 0.59014
korA, oorA, oforA; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11] 1.70934 0.25260 1.47332 6.59090 0.31843 65 1.87430 12.55290 0.36739 93 0.48619 -0.82477 155.774 0.41077 0.59014
korB, oorB, oforB; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11] 1.70934 0.25260 1.47332 6.59090 0.31843 65 1.87430 12.55290 0.36739 93 0.48619 -0.82477 155.774 0.41077 0.59014
galM, GALM; aldose 1-epimerase [EC:5.1.3.3] 1.70764 0.25264 1.46971 6.59844 0.31861 65 1.87393 12.55117 0.36737 93 0.48629 -0.83125 155.767 0.40710 0.59014
TC.MATE, SLC47A, norM, mdtK, dinF; multidrug resistance protein, MATE family 1.70218 0.25314 1.48032 6.65813 0.32005 65 1.85725 12.58751 0.36790 93 0.48763 -0.77299 155.729 0.44070 0.59014
ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60] 1.69935 0.25200 1.47342 6.59059 0.31842 65 1.85725 12.47603 0.36627 93 0.48533 -0.79086 155.737 0.43023 0.59014
folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3] 1.68931 0.24805 1.45698 6.34169 0.31235 65 1.85169 12.11350 0.36091 93 0.47730 -0.82696 155.791 0.40952 0.59014
coaE; dephospho-CoA kinase [EC:2.7.1.24] 1.68603 0.25086 1.46493 6.48323 0.31582 65 1.84056 12.39950 0.36514 93 0.48277 -0.77807 155.798 0.43771 0.59014
algI; alginate O-acetyltransferase complex protein AlgI 1.66878 0.46286 1.45641 19.48462 0.54751 65 1.81720 44.15584 0.68905 93 0.88009 -0.40995 155.652 0.68241 0.75298
cobA, btuR; cob(I)alamin adenosyltransferase [EC:2.5.1.17] 1.66878 0.46286 1.45641 19.48462 0.54751 65 1.81720 44.15584 0.68905 93 0.88009 -0.40995 155.652 0.68241 0.75298
dcuB; anaerobic C4-dicarboxylate transporter DcuB 1.66878 0.46286 1.45641 19.48462 0.54751 65 1.81720 44.15584 0.68905 93 0.88009 -0.40995 155.652 0.68241 0.75298
E4.2.1.2AA, fumA; fumarate hydratase subunit alpha [EC:4.2.1.2] 1.66878 0.46286 1.45641 19.48462 0.54751 65 1.81720 44.15584 0.68905 93 0.88009 -0.40995 155.652 0.68241 0.75298
E4.2.1.2AB, fumB; fumarate hydratase subunit beta [EC:4.2.1.2] 1.66878 0.46286 1.45641 19.48462 0.54751 65 1.81720 44.15584 0.68905 93 0.88009 -0.40995 155.652 0.68241 0.75298
glmE, mutE, mamB; methylaspartate mutase epsilon subunit [EC:5.4.99.1] 1.66878 0.46286 1.45641 19.48462 0.54751 65 1.81720 44.15584 0.68905 93 0.88009 -0.40995 155.652 0.68241 0.75298
glmS, mutS, mamA; methylaspartate mutase sigma subunit [EC:5.4.99.1] 1.66878 0.46286 1.45641 19.48462 0.54751 65 1.81720 44.15584 0.68905 93 0.88009 -0.40995 155.652 0.68241 0.75298
inlA; internalin A 1.66878 0.46286 1.45641 19.48462 0.54751 65 1.81720 44.15584 0.68905 93 0.88009 -0.40995 155.652 0.68241 0.75298
mal; methylaspartate ammonia-lyase [EC:4.3.1.2] 1.66878 0.46286 1.45641 19.48462 0.54751 65 1.81720 44.15584 0.68905 93 0.88009 -0.40995 155.652 0.68241 0.75298
PCYT1; choline-phosphate cytidylyltransferase [EC:2.7.7.15] 1.66878 0.46286 1.45641 19.48462 0.54751 65 1.81720 44.15584 0.68905 93 0.88009 -0.40995 155.652 0.68241 0.75298
tnaA; tryptophanase [EC:4.1.99.1] 1.66878 0.46286 1.45641 19.48462 0.54751 65 1.81720 44.15584 0.68905 93 0.88009 -0.40995 155.652 0.68241 0.75298
icmF; isobutyryl-CoA mutase [EC:5.4.99.13] 1.66561 0.25721 1.44786 5.53394 0.29178 65 1.81780 13.93145 0.38704 93 0.48470 -0.76323 154.536 0.44649 0.59014
hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3] 1.66377 0.23703 1.44637 5.81089 0.29900 65 1.81572 11.04920 0.34469 93 0.45630 -0.80946 155.765 0.41948 0.59014
treS; maltose alpha-D-glucosyltransferase / alpha-amylase [EC:5.4.99.16 3.2.1.1] 1.65506 0.61136 1.09231 14.98353 0.48012 65 2.04839 89.97318 0.98359 93 1.09452 -0.87352 130.421 0.38399 0.59014
GLPF; glycerol uptake facilitator protein 1.64376 0.27456 1.57143 7.20663 0.33297 65 1.69432 15.30550 0.40568 93 0.52483 -0.23415 155.961 0.81518 0.85972
glpK, GK; glycerol kinase [EC:2.7.1.30] 1.64376 0.27456 1.57143 7.20663 0.33297 65 1.69432 15.30550 0.40568 93 0.52483 -0.23415 155.961 0.81518 0.85972
gph; phosphoglycolate phosphatase [EC:3.1.3.18] 1.63605 0.22237 1.42621 4.85721 0.27336 65 1.78272 9.90094 0.32628 93 0.42566 -0.83755 155.997 0.40356 0.59014
panE, apbA; 2-dehydropantoate 2-reductase [EC:1.1.1.169] 1.61850 0.25853 1.41368 5.91609 0.30169 65 1.76165 13.85538 0.38598 93 0.48990 -0.71030 155.382 0.47858 0.59720
csm1, cas10; CRISPR-associated protein Csm1 1.61392 1.05415 0.55385 3.68846 0.23821 65 2.35484 295.70968 1.78316 93 1.79901 -1.00110 95.269 0.31931 0.59014
csm2; CRISPR-associated protein Csm2 1.61392 1.05415 0.55385 3.68846 0.23821 65 2.35484 295.70968 1.78316 93 1.79901 -1.00110 95.269 0.31931 0.59014
csm3; CRISPR-associated protein Csm3 1.61392 1.05415 0.55385 3.68846 0.23821 65 2.35484 295.70968 1.78316 93 1.79901 -1.00110 95.269 0.31931 0.59014
K07088; uncharacterized protein 1.59991 0.26952 1.51648 7.31741 0.33552 65 1.65822 14.48800 0.39470 93 0.51804 -0.27360 155.945 0.78475 0.83755
sanA; SanA protein 1.59991 0.26952 1.51648 7.31741 0.33552 65 1.65822 14.48800 0.39470 93 0.51804 -0.27360 155.945 0.78475 0.83755
E2.7.1.4, scrK; fructokinase [EC:2.7.1.4] 1.59684 0.23344 1.37824 5.35937 0.28714 65 1.74962 10.90726 0.34247 93 0.44692 -0.83097 155.996 0.40726 0.59014
aspB; aspartate aminotransferase [EC:2.6.1.1] 1.59236 0.22338 1.37716 4.39429 0.26001 65 1.74276 10.34194 0.33347 93 0.42286 -0.86460 155.335 0.38859 0.59014
map; methionyl aminopeptidase [EC:3.4.11.18] 1.59022 0.22308 1.38536 4.92936 0.27538 65 1.73341 9.93905 0.32691 93 0.42744 -0.81426 155.985 0.41674 0.59014
pflA, pflC, pflE; pyruvate formate lyase activating enzyme [EC:1.97.1.4] 1.59006 0.23298 1.41778 5.82845 0.29945 65 1.71047 10.54574 0.33674 93 0.45063 -0.64953 155.370 0.51695 0.62047
nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6] 1.57069 0.22173 1.36710 4.29694 0.25711 65 1.71299 10.21754 0.33146 93 0.41949 -0.82454 155.232 0.41090 0.59014
NAGLU; alpha-N-acetylglucosaminidase [EC:3.2.1.50] 1.56804 0.57661 0.87308 9.23266 0.37688 65 2.05376 82.64518 0.94269 93 1.01523 -1.16297 119.376 0.24716 0.59014
cobN; cobaltochelatase CobN [EC:6.6.1.2] 1.56013 0.31434 1.25897 7.86721 0.34790 65 1.77061 21.05973 0.47587 93 0.58948 -0.86795 153.565 0.38678 0.59014
acrA, mexA, adeI, smeD, mtrC, cmeA; membrane fusion protein, multidrug efflux system 1.54522 0.20843 1.35289 4.34873 0.25866 65 1.67964 8.64356 0.30486 93 0.39981 -0.81728 155.956 0.41502 0.59014
TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family 1.54522 0.20843 1.35289 4.34873 0.25866 65 1.67964 8.64356 0.30486 93 0.39981 -0.81728 155.956 0.41502 0.59014
mrdA; penicillin-binding protein 2 [EC:3.4.16.4] 1.51008 0.22165 1.34122 5.26436 0.28459 65 1.62811 9.54999 0.32045 93 0.42858 -0.66939 155.395 0.50424 0.60887
SPP; sucrose-6-phosphatase [EC:3.1.3.24] 1.50707 0.21096 1.32647 4.14615 0.25256 65 1.63330 9.07591 0.31239 93 0.40172 -0.76378 155.855 0.44615 0.59014
pepO; putative endopeptidase [EC:3.4.24.-] 1.50314 0.22186 1.33655 5.27597 0.28490 65 1.61958 9.56843 0.32076 93 0.42902 -0.65971 155.393 0.51042 0.61441
ytfE, scdA; regulator of cell morphogenesis and NO signaling 1.49790 0.20673 1.31162 4.19327 0.25399 65 1.62811 8.56459 0.30347 93 0.39573 -0.79975 155.998 0.42507 0.59014
mutT, NUDT15, MTH2; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 1.48703 0.23488 1.37615 6.41118 0.31406 65 1.56452 10.40014 0.33441 93 0.45876 -0.41059 153.832 0.68195 0.75298
E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] 1.48586 0.21233 1.33273 5.31387 0.28592 65 1.59288 8.43176 0.30110 93 0.41523 -0.62652 153.411 0.53191 0.63304
fsr; MFS transporter, FSR family, fosmidomycin resistance protein 1.46559 0.24027 1.39615 5.79984 0.29871 65 1.51411 11.52566 0.35204 93 0.46169 -0.25549 155.955 0.79868 0.85163
ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63] 1.45781 0.39995 0.96410 5.34765 0.28683 65 1.80287 39.11651 0.64854 93 0.70914 -1.18279 124.655 0.23914 0.59014
LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4] 1.44723 0.20945 1.26218 4.66661 0.26794 65 1.57657 8.54070 0.30304 93 0.40451 -0.77721 155.478 0.43821 0.59014
dam; DNA adenine methylase [EC:2.1.1.72] 1.44051 0.24781 1.29538 5.87607 0.30067 65 1.54194 12.44550 0.36582 93 0.47352 -0.52067 155.968 0.60333 0.69037
SERPINB; serpin B 1.43631 0.23694 1.32692 5.60239 0.29358 65 1.51277 11.22542 0.34742 93 0.45486 -0.40858 155.974 0.68341 0.75298
UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27] 1.42115 0.21151 1.25422 4.39841 0.26013 65 1.53782 8.96938 0.31056 93 0.40511 -0.70007 155.997 0.48493 0.60187
acpP; acyl carrier protein 1.42010 0.21826 1.12647 3.31796 0.22593 65 1.62532 10.43263 0.33493 93 0.40401 -1.23475 150.100 0.21885 0.59014
agp; glucose-1-phosphatase [EC:3.1.3.10] 1.41667 0.21186 1.35726 4.45679 0.26185 65 1.45818 8.99823 0.31105 93 0.40660 -0.24820 155.987 0.80430 0.85291
E5.2.1.8; peptidylprolyl isomerase [EC:5.2.1.8] 1.40625 0.23569 1.34038 5.58130 0.29303 65 1.45228 11.08962 0.34532 93 0.45289 -0.24708 155.955 0.80517 0.85305
K07126; uncharacterized protein 1.40506 0.35581 1.18462 11.17632 0.41466 65 1.55914 26.30217 0.53181 93 0.67436 -0.55538 155.336 0.57944 0.67436
thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7] 1.40152 0.21274 1.29254 5.40085 0.28825 65 1.47770 8.43109 0.30109 93 0.41683 -0.44422 153.077 0.65751 0.73851
aguA; alpha-glucuronidase [EC:3.2.1.139] 1.39304 0.57095 0.81692 9.16612 0.37552 65 1.79570 81.12085 0.93395 93 1.00662 -0.97234 119.656 0.33284 0.59014
fabB; 3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41] 1.38633 0.32063 0.84215 2.57519 0.19904 65 1.76667 25.57225 0.52438 93 0.56088 -1.64832 116.932 0.10197 0.59014
glnA, GLUL; glutamine synthetase [EC:6.3.1.2] 1.38595 0.19733 1.22302 4.19249 0.25397 65 1.49981 7.55094 0.28494 93 0.38170 -0.72516 155.324 0.46945 0.59347
kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45] 1.38101 0.38355 0.94593 8.18439 0.35484 65 1.68510 33.74515 0.60237 93 0.69912 -1.05728 142.297 0.29217 0.59014
kup; KUP system potassium uptake protein 1.37880 0.20989 1.30000 4.69031 0.26862 65 1.43387 8.60800 0.30424 93 0.40585 -0.32985 155.503 0.74196 0.79850
moxR; MoxR-like ATPase [EC:3.6.3.-] 1.37241 0.18981 1.23735 3.74018 0.23988 65 1.46681 7.09041 0.27612 93 0.36576 -0.62737 155.746 0.53134 0.63301
cysE; serine O-acetyltransferase [EC:2.3.1.30] 1.36414 0.19280 1.24018 3.82836 0.24269 65 1.45079 7.34149 0.28096 93 0.37127 -0.56727 155.813 0.57135 0.66696
mviM; virulence factor 1.35979 0.21656 1.15621 3.95654 0.24672 65 1.50207 9.84250 0.32532 93 0.40829 -0.84708 154.698 0.39826 0.59014
K15977; putative oxidoreductase 1.35970 0.18726 1.31987 4.04504 0.24946 65 1.38754 6.63884 0.26718 93 0.36554 -0.18513 154.040 0.85337 0.89673
hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1] 1.35886 0.21962 1.34752 7.16264 0.33196 65 1.36679 8.02275 0.29371 93 0.44324 -0.04346 142.623 0.96539 0.96958
E3.2.1.22B, galA, rafA; alpha-galactosidase [EC:3.2.1.22] 1.35490 0.18980 1.22355 3.46868 0.23101 65 1.44670 7.27929 0.27977 93 0.36282 -0.61507 155.985 0.53940 0.63858
E1.4.1.4, gdhA; glutamate dehydrogenase (NADP+) [EC:1.4.1.4] 1.35029 0.19046 1.22951 4.15986 0.25298 65 1.43472 6.86956 0.27178 93 0.37130 -0.55268 154.145 0.58128 0.67515
PPIB, ppiB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8] 1.34567 0.20077 1.23163 4.43243 0.26113 65 1.42538 7.76911 0.28903 93 0.38953 -0.49739 155.017 0.61962 0.70276
E5.1.3.6; UDP-glucuronate 4-epimerase [EC:5.1.3.6] 1.34494 0.37843 1.30000 13.55312 0.45663 65 1.37634 29.18291 0.56017 93 0.72271 -0.10564 155.921 0.91601 0.94278
glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3] 1.34124 0.21694 1.16538 3.46256 0.23080 65 1.46416 10.24342 0.33188 93 0.40425 -0.73909 151.551 0.46100 0.59014
glpB; glycerol-3-phosphate dehydrogenase subunit B [EC:1.1.5.3] 1.34124 0.21694 1.16538 3.46256 0.23080 65 1.46416 10.24342 0.33188 93 0.40425 -0.73909 151.551 0.46100 0.59014
glpC; glycerol-3-phosphate dehydrogenase subunit C [EC:1.1.5.3] 1.34124 0.21694 1.16538 3.46256 0.23080 65 1.46416 10.24342 0.33188 93 0.40425 -0.73909 151.551 0.46100 0.59014
E3.1.6.1, aslA; arylsulfatase [EC:3.1.6.1] 1.33931 0.22182 1.23761 4.97468 0.27665 65 1.41039 9.79395 0.32452 93 0.42643 -0.40519 155.927 0.68589 0.75500
malZ; alpha-glucosidase [EC:3.2.1.20] 1.32077 0.19689 1.23077 3.89749 0.24487 65 1.38368 7.73111 0.28832 93 0.37827 -0.40422 155.950 0.68660 0.75507
hsdM; type I restriction enzyme M protein [EC:2.1.1.72] 1.30624 0.19202 1.13584 3.60830 0.23561 65 1.42533 7.39726 0.28203 93 0.36750 -0.78773 156.000 0.43205 0.59014
ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-] 1.29832 0.20019 1.02753 2.82302 0.20840 65 1.48758 8.75422 0.30681 93 0.37089 -1.24037 150.443 0.21677 0.59014
K07387; putative metalloprotease [EC:3.4.24.-] 1.29625 0.19954 1.11243 2.96081 0.21343 65 1.42473 8.63519 0.30472 93 0.37202 -0.83947 151.868 0.40252 0.59014
dpo; DNA polymerase bacteriophage-type [EC:2.7.7.7] 1.27848 0.34367 1.55385 17.46971 0.51843 65 1.08602 19.60122 0.45909 93 0.69248 0.67558 142.692 0.50040 0.60550
epsD; glycosyltransferase EpsD [EC:2.4.-.-] 1.27848 0.34367 1.55385 17.46971 0.51843 65 1.08602 19.60122 0.45909 93 0.69248 0.67558 142.692 0.50040 0.60550
K06904; uncharacterized protein 1.27848 0.34367 1.55385 17.46971 0.51843 65 1.08602 19.60122 0.45909 93 0.69248 0.67558 142.692 0.50040 0.60550
K07270; glycosyl transferase, family 25 1.27848 0.34367 1.55385 17.46971 0.51843 65 1.08602 19.60122 0.45909 93 0.69248 0.67558 142.692 0.50040 0.60550
K09137; uncharacterized protein 1.27848 0.34367 1.55385 17.46971 0.51843 65 1.08602 19.60122 0.45909 93 0.69248 0.67558 142.692 0.50040 0.60550
kch, trkA, mthK, pch; voltage-gated potassium channel 1.27848 0.34367 1.55385 17.46971 0.51843 65 1.08602 19.60122 0.45909 93 0.69248 0.67558 142.692 0.50040 0.60550
mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-] 1.27848 0.34367 1.55385 17.46971 0.51843 65 1.08602 19.60122 0.45909 93 0.69248 0.67558 142.692 0.50040 0.60550
mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC 1.27848 0.34367 1.55385 17.46971 0.51843 65 1.08602 19.60122 0.45909 93 0.69248 0.67558 142.692 0.50040 0.60550
PNC1; nicotinamidase [EC:3.5.1.19] 1.27848 0.34367 1.55385 17.46971 0.51843 65 1.08602 19.60122 0.45909 93 0.69248 0.67558 142.692 0.50040 0.60550
rgpB; rhamnosyltransferase [EC:2.4.1.-] 1.27848 0.34367 1.55385 17.46971 0.51843 65 1.08602 19.60122 0.45909 93 0.69248 0.67558 142.692 0.50040 0.60550
tagD; glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39] 1.27848 0.34367 1.55385 17.46971 0.51843 65 1.08602 19.60122 0.45909 93 0.69248 0.67558 142.692 0.50040 0.60550
MAN; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78] 1.27563 0.18545 1.13648 3.40006 0.22871 65 1.37289 6.88497 0.27209 93 0.35544 -0.66510 155.991 0.50697 0.61090
K06871; uncharacterized protein 1.27416 0.20132 1.04891 3.24064 0.22328 65 1.43159 8.61287 0.30432 93 0.37745 -1.01385 153.689 0.31225 0.59014
E3.1.1.11; pectinesterase [EC:3.1.1.11] 1.26456 0.39162 0.80718 4.46182 0.26200 65 1.58423 37.99675 0.63919 93 0.69080 -1.12485 120.617 0.26289 0.59014
kduI; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase [EC:5.3.1.17] 1.26414 0.39163 0.80615 4.46329 0.26204 65 1.58423 37.99675 0.63919 93 0.69082 -1.12631 120.625 0.26227 0.59014
PTS-Gat-EIIC, gatC, sgcC; PTS system, galactitol-specific IIC component 1.26414 0.39163 0.80615 4.46329 0.26204 65 1.58423 37.99675 0.63919 93 0.69082 -1.12631 120.625 0.26227 0.59014
uxaA; altronate hydrolase [EC:4.2.1.7] 1.26414 0.39163 0.80615 4.46329 0.26204 65 1.58423 37.99675 0.63919 93 0.69082 -1.12631 120.625 0.26227 0.59014
uxaB; tagaturonate reductase [EC:1.1.1.58] 1.26414 0.39163 0.80615 4.46329 0.26204 65 1.58423 37.99675 0.63919 93 0.69082 -1.12631 120.625 0.26227 0.59014
K02477; two-component system, LytTR family, response regulator 1.25190 0.34713 1.09308 10.95843 0.41060 65 1.36290 24.83766 0.51679 93 0.66005 -0.40880 155.651 0.68325 0.75298
E4.1.3.3, nanA, NPL; N-acetylneuraminate lyase [EC:4.1.3.3] 1.24747 0.17966 1.09949 2.55363 0.19821 65 1.35090 6.90057 0.27240 93 0.33688 -0.74629 153.397 0.45663 0.59014
K07454; putative restriction endonuclease 1.24684 0.64160 1.24615 84.15721 1.13786 65 1.24731 52.44904 0.75098 93 1.36334 -0.00085 116.519 0.99932 0.99932
rgpA_B; gingipain R [EC:3.4.22.37] 1.24684 0.64160 1.24615 84.15721 1.13786 65 1.24731 52.44904 0.75098 93 1.36334 -0.00085 116.519 0.99932 0.99932
metY; O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49] 1.22934 0.18238 1.08240 3.28065 0.22466 65 1.33204 6.66094 0.26762 93 0.34942 -0.71445 155.994 0.47602 0.59592
licD; lipopolysaccharide cholinephosphotransferase [EC:2.7.8.-] 1.22844 0.18331 1.10355 3.79335 0.24158 65 1.31572 6.40294 0.26239 93 0.35666 -0.59487 154.497 0.55280 0.64989
cusB, silB; membrane fusion protein, Cu(I)/Ag(I) efflux system 1.22152 0.31319 1.25385 12.96190 0.44656 65 1.19892 17.43011 0.43292 93 0.62196 0.08830 149.171 0.92975 0.94278
metH, MTR; 5-methyltetrahydrofolate–homocysteine methyltransferase [EC:2.1.1.13] 1.21907 0.18450 1.07449 3.26570 0.22415 65 1.32012 6.88104 0.27201 93 0.35246 -0.69689 155.978 0.48691 0.60286
hya; hyaluronoglucosaminidase [EC:3.2.1.35] 1.20863 0.18683 1.03736 2.53613 0.19753 65 1.32834 7.61253 0.28610 93 0.34767 -0.83694 151.219 0.40394 0.59014
E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1] 1.20334 0.19490 1.02451 3.97096 0.24717 65 1.32833 7.44163 0.28287 93 0.37565 -0.80879 155.669 0.41987 0.59014
cbe, mbe; cellobiose epimerase [EC:5.1.3.11] 1.19937 0.33040 0.81538 6.28179 0.31087 65 1.46774 24.88754 0.51731 93 0.60353 -1.08090 143.538 0.28155 0.59014
mgp; 4-O-beta-D-mannosyl-D-glucose phosphorylase [EC:2.4.1.281] 1.19937 0.33040 0.81538 6.28179 0.31087 65 1.46774 24.88754 0.51731 93 0.60353 -1.08090 143.538 0.28155 0.59014
nhaA; Na+:H+ antiporter, NhaA family 1.19753 0.17902 1.05628 3.67865 0.23790 65 1.29626 6.05811 0.25523 93 0.34891 -0.68783 154.098 0.49259 0.60550
ABC.CD.P; putative ABC transport system permease protein 1.19611 0.28547 0.78201 6.08754 0.30603 65 1.48553 17.53267 0.43419 93 0.53120 -1.32437 152.139 0.18736 0.59014
ldhA; D-lactate dehydrogenase [EC:1.1.1.28] 1.19488 0.16852 1.13333 2.77166 0.20650 65 1.23790 5.72496 0.24811 93 0.32280 -0.32395 155.999 0.74641 0.80237
fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] 1.17501 0.17336 0.94743 2.41854 0.19289 65 1.33407 6.35848 0.26148 93 0.32493 -1.18994 153.873 0.23590 0.59014
glxK, garK; glycerate 2-kinase [EC:2.7.1.165] 1.17495 0.18401 1.03538 3.52709 0.23294 65 1.27250 6.65223 0.26745 93 0.35467 -0.66854 155.713 0.50478 0.60889
tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] 1.17245 0.18913 1.01953 3.52469 0.23286 65 1.27934 7.16494 0.27757 93 0.36231 -0.71708 155.995 0.47440 0.59518
E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2] 1.17169 0.16825 1.07809 3.36481 0.22752 65 1.23712 5.28178 0.23831 93 0.32948 -0.48265 153.192 0.63003 0.71387
fucP; MFS transporter, FHS family, L-fucose permease 1.16825 0.16725 0.97793 2.68789 0.20335 65 1.30126 5.62901 0.24602 93 0.31919 -1.01298 155.988 0.31264 0.59014
hlyIII; hemolysin III 1.16781 0.19075 1.03154 3.10997 0.21874 65 1.26306 7.62508 0.28634 93 0.36033 -0.64252 154.884 0.52148 0.62384
K08884; serine/threonine protein kinase, bacterial [EC:2.7.11.1] 1.16715 0.18260 1.10070 3.29820 0.22526 65 1.21359 6.69079 0.26822 93 0.35026 -0.32229 155.993 0.74766 0.80237
nosL; copper chaperone NosL 1.16456 0.54031 0.95385 37.38846 0.75842 65 1.31183 52.65171 0.75243 93 1.06834 -0.33508 150.536 0.73803 0.79501
oprO_P; phosphate-selective porin OprO and OprP 1.15605 0.16847 1.03558 2.23565 0.18546 65 1.24026 6.08012 0.25569 93 0.31587 -0.64799 153.280 0.51796 0.62091
lepB; signal peptidase I [EC:3.4.21.89] 1.15362 0.16620 1.00605 2.79378 0.20732 65 1.25677 5.47819 0.24270 93 0.31920 -0.78547 155.913 0.43337 0.59014
mntH; manganese transport protein 1.14789 0.17859 1.00000 2.42437 0.19313 65 1.25125 6.88687 0.27213 93 0.33369 -0.75295 152.428 0.45264 0.59014
E3.1.3.1, phoA, phoB; alkaline phosphatase [EC:3.1.3.1] 1.14684 0.25842 0.88923 3.79879 0.24175 65 1.32688 15.28416 0.40540 93 0.47200 -0.92722 143.060 0.35538 0.59014
ald; alanine dehydrogenase [EC:1.4.1.1] 1.14557 0.30192 0.74615 3.00877 0.21515 65 1.42473 22.29454 0.48962 93 0.53480 -1.26883 124.297 0.20687 0.59014
K07058; membrane protein 1.13994 0.17017 0.99015 3.23971 0.22325 65 1.24462 5.52682 0.24378 93 0.33056 -0.76981 154.655 0.44258 0.59014
K06885; uncharacterized protein 1.13515 0.16799 1.05928 3.06616 0.21719 65 1.18817 5.46965 0.24251 93 0.32555 -0.39593 155.222 0.69270 0.75849
E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19] 1.13063 0.25296 0.88985 3.75645 0.24040 65 1.29892 14.57011 0.39581 93 0.46310 -0.88335 144.189 0.37852 0.59014
K07727; putative transcriptional regulator 1.12785 0.31577 0.99077 9.50929 0.38249 65 1.22366 20.24770 0.46660 93 0.60334 -0.38600 155.955 0.70002 0.76402
ybaZ; methylated-DNA-protein-cysteine methyltransferase related protein 1.12243 0.17770 0.98462 2.70905 0.20415 65 1.21875 6.60687 0.26654 93 0.33574 -0.69738 154.949 0.48661 0.60286
cynT, can; carbonic anhydrase [EC:4.2.1.1] 1.12238 0.18217 1.01287 3.32961 0.22633 65 1.19892 6.61767 0.26675 93 0.34983 -0.53185 155.956 0.59559 0.68219
bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] 1.12209 0.16612 0.92515 2.57597 0.19907 65 1.25973 5.60195 0.24543 93 0.31602 -1.05876 155.884 0.29134 0.59014
mrr; restriction system protein 1.11392 0.31049 0.92308 3.93149 0.24594 65 1.24731 23.21535 0.49963 93 0.55688 -0.58224 130.934 0.56141 0.65734
abgT; aminobenzoyl-glutamate transport protein 1.10814 0.16890 1.02879 3.19546 0.22172 65 1.16359 5.46169 0.24234 93 0.32846 -0.41040 154.682 0.68208 0.75298
glpT; MFS transporter, OPA family, glycerol-3-phosphate transporter 1.10601 0.29987 0.75000 3.01562 0.21539 65 1.35484 21.99636 0.48633 93 0.53190 -1.13714 124.733 0.25766 0.59014
mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72] 1.09620 0.24077 0.98769 5.41679 0.28868 65 1.17204 11.84870 0.35694 93 0.45906 -0.40158 155.859 0.68854 0.75648
PREP; prolyl oligopeptidase [EC:3.4.21.26] 1.09605 0.17348 0.96352 3.09898 0.21835 65 1.18868 5.93799 0.25268 93 0.33396 -0.67425 155.809 0.50115 0.60578
terC; tellurite resistance protein TerC 1.09367 0.29995 0.72385 3.00696 0.21508 65 1.35215 22.00304 0.48641 93 0.53184 -1.18138 124.645 0.23970 0.59014
thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148] 1.09367 0.29995 0.72385 3.00696 0.21508 65 1.35215 22.00304 0.48641 93 0.53184 -1.18138 124.645 0.23970 0.59014
AMY, amyA, malS; alpha-amylase [EC:3.2.1.1] 1.08983 0.16030 0.92148 2.14612 0.18171 65 1.20749 5.40175 0.24100 93 0.30183 -0.94758 154.539 0.34482 0.59014
kbl, GCAT; glycine C-acetyltransferase [EC:2.3.1.29] 1.08936 0.19753 0.88974 2.30356 0.18825 65 1.22888 8.86981 0.30883 93 0.36168 -0.93766 144.411 0.34998 0.59014
trpC; indole-3-glycerol phosphate synthase [EC:4.1.1.48] 1.08875 0.22804 0.85846 5.14544 0.28135 65 1.24970 10.37860 0.33406 93 0.43676 -0.89578 155.986 0.37175 0.59014
dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-] 1.08466 0.16430 0.90631 2.54642 0.19793 65 1.20931 5.46909 0.24250 93 0.31302 -0.96796 155.930 0.33456 0.59014
dps; starvation-inducible DNA-binding protein 1.08310 0.15848 0.94482 2.65002 0.20191 65 1.17976 4.90594 0.22968 93 0.30581 -0.76825 155.576 0.44350 0.59014
glk; glucokinase [EC:2.7.1.2] 1.08069 0.15300 0.91523 2.08960 0.17930 65 1.19633 4.82502 0.22778 93 0.28988 -0.96973 155.508 0.33369 0.59014
dfx; superoxide reductase [EC:1.15.1.2] 1.07949 0.16837 0.97557 3.03351 0.21603 65 1.15212 5.52058 0.24364 93 0.32562 -0.54220 155.426 0.58846 0.67888
dcuA; anaerobic C4-dicarboxylate transporter DcuA 1.07665 0.24521 0.88205 6.09795 0.30629 65 1.21266 11.92422 0.35807 93 0.47120 -0.70164 155.903 0.48395 0.60131
INO1, ISYNA1; myo-inositol-1-phosphate synthase [EC:5.5.1.4] 1.06705 0.17302 0.97795 3.53452 0.23319 65 1.12933 5.60300 0.24545 93 0.33856 -0.44713 153.392 0.65541 0.73686
serB, PSPH; phosphoserine phosphatase [EC:3.1.3.3] 1.06604 0.16400 0.92092 3.01917 0.21552 65 1.16747 5.12606 0.23477 93 0.31870 -0.77362 154.585 0.44034 0.59014
K07005; uncharacterized protein 1.06111 0.17224 0.92148 3.22300 0.22268 65 1.15870 5.73368 0.24830 93 0.33352 -0.71126 155.192 0.47799 0.59710
ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4] 1.05995 0.16396 0.92053 2.90314 0.21134 65 1.15740 5.20582 0.23659 93 0.31724 -0.74665 155.278 0.45640 0.59014
FTCD; glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase [EC:2.1.2.5 4.3.1.4] 1.05802 0.17069 0.95855 3.47823 0.23132 65 1.12754 5.42424 0.24151 93 0.33442 -0.50533 153.056 0.61405 0.69919
hutH, HAL; histidine ammonia-lyase [EC:4.3.1.3] 1.05802 0.17069 0.95855 3.47823 0.23132 65 1.12754 5.42424 0.24151 93 0.33442 -0.50533 153.056 0.61405 0.69919
hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7] 1.05802 0.17069 0.95855 3.47823 0.23132 65 1.12754 5.42424 0.24151 93 0.33442 -0.50533 153.056 0.61405 0.69919
hutU, UROC1; urocanate hydratase [EC:4.2.1.49] 1.05802 0.17069 0.95855 3.47823 0.23132 65 1.12754 5.42424 0.24151 93 0.33442 -0.50533 153.056 0.61405 0.69919
pncA; nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-] 1.05680 0.16226 0.99676 3.08655 0.21791 65 1.09875 4.94772 0.23065 93 0.31731 -0.32143 153.610 0.74832 0.80237
K07003; uncharacterized protein 1.05654 0.17686 0.90667 2.63456 0.20132 65 1.16129 6.57433 0.26588 93 0.33350 -0.76349 154.657 0.44634 0.59014
rnfG; electron transport complex protein RnfG 1.05371 0.16546 0.91902 2.82409 0.20844 65 1.14785 5.39544 0.24086 93 0.31853 -0.71838 155.792 0.47360 0.59518
ahpF; alkyl hydroperoxide reductase subunit F [EC:1.6.4.-] 1.04830 0.16066 0.97530 3.06455 0.21713 65 1.09932 4.82177 0.22770 93 0.31463 -0.39416 153.241 0.69401 0.75849
tex; protein Tex 1.04739 0.15224 0.92890 2.45406 0.19431 65 1.13020 4.52556 0.22059 93 0.29397 -0.68479 155.544 0.49450 0.60550
ABC-2.OM, wza; polysaccharide biosynthesis/export protein 1.03813 0.15560 0.86960 2.12907 0.18098 65 1.15591 5.01277 0.23217 93 0.29437 -0.97261 155.332 0.33226 0.59014
cpdB; 2’,3’-cyclic-nucleotide 2’-phosphodiesterase / 3’-nucleotidase [EC:3.1.4.16 3.1.3.6] 1.03813 0.15560 0.86960 2.12907 0.18098 65 1.15591 5.01277 0.23217 93 0.29437 -0.97261 155.332 0.33226 0.59014
fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] 1.03420 0.16752 0.90143 3.04246 0.21635 65 1.12699 5.42925 0.24162 93 0.32432 -0.69548 155.226 0.48780 0.60286
gltD; glutamate synthase (NADPH/NADH) small chain [EC:1.4.1.13 1.4.1.14] 1.03280 0.15847 0.84319 2.11677 0.18046 65 1.16532 5.25552 0.23772 93 0.29846 -1.07934 154.724 0.28212 0.59014
aspA; aspartate ammonia-lyase [EC:4.3.1.1] 1.02337 0.15977 0.87191 2.22413 0.18498 65 1.12923 5.30824 0.23891 93 0.30215 -0.85164 155.194 0.39573 0.59014
buk; butyrate kinase [EC:2.7.2.7] 1.02182 0.16349 0.93441 3.15985 0.22048 65 1.08291 4.99974 0.23186 93 0.31996 -0.46411 153.355 0.64323 0.72528
ptb; phosphate butyryltransferase [EC:2.3.1.19] 1.02182 0.16349 0.93441 3.15985 0.22048 65 1.08291 4.99974 0.23186 93 0.31996 -0.46411 153.355 0.64323 0.72528
rluA; tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29] 1.02173 0.16584 0.89071 2.97830 0.21406 65 1.11330 5.32313 0.23924 93 0.32103 -0.69337 155.243 0.48912 0.60319
pdxK, pdxY; pyridoxine kinase [EC:2.7.1.35] 1.02128 0.15197 0.91167 2.41098 0.19259 65 1.09789 4.53521 0.22083 93 0.29301 -0.63556 155.695 0.52600 0.62749
ATOX1, ATX1, copZ, golB; copper chaperone 1.02056 0.15883 0.87906 2.58386 0.19938 65 1.11945 4.98020 0.23141 93 0.30545 -0.78698 155.839 0.43249 0.59014
wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14] 1.01984 0.14519 0.85273 1.82545 0.16758 65 1.13663 4.38041 0.21703 93 0.27420 -1.03538 155.135 0.30210 0.59014
K07052; uncharacterized protein 1.01969 0.13517 0.87385 1.91481 0.17164 65 1.12162 3.56846 0.19588 93 0.26044 -0.95135 155.628 0.34290 0.59014
hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9] 1.01905 0.14116 0.92515 1.83094 0.16783 65 1.08468 4.08823 0.20967 93 0.26857 -0.59398 155.750 0.55339 0.64992
radA, sms; DNA repair protein RadA/Sms 1.01805 0.15154 0.85316 1.99073 0.17500 65 1.13330 4.77463 0.22658 93 0.28630 -0.97849 155.141 0.32936 0.59014
crcB, FEX; fluoride exporter 1.01696 0.15512 0.87756 2.30760 0.18842 65 1.11439 4.85906 0.22858 93 0.29623 -0.79948 155.979 0.42523 0.59014
fes; enterochelin esterase and related enzymes 1.00904 0.15526 0.88949 2.15418 0.18205 65 1.09259 4.98431 0.23151 93 0.29451 -0.68964 155.490 0.49145 0.60478
dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7] 1.00849 0.14842 0.88589 2.52045 0.19692 65 1.09418 4.16802 0.21170 93 0.28913 -0.72041 154.169 0.47236 0.59518
eptC; heptose-I-phosphate ethanolaminephosphotransferase [EC:2.7.8.-] 1.00264 0.13762 0.86687 1.96035 0.17366 65 1.09754 3.72060 0.20002 93 0.26489 -0.87084 155.753 0.38518 0.59014
rhaA; L-rhamnose isomerase [EC:5.3.1.14] 0.99831 0.38400 0.57538 4.10133 0.25119 65 1.29391 36.69046 0.62811 93 0.67647 -1.06216 119.391 0.29031 0.59014
rhaB; rhamnulokinase [EC:2.7.1.5] 0.99831 0.38400 0.57538 4.10133 0.25119 65 1.29391 36.69046 0.62811 93 0.67647 -1.06216 119.391 0.29031 0.59014
rhaD; rhamnulose-1-phosphate aldolase [EC:4.1.2.19] 0.99831 0.38400 0.57538 4.10133 0.25119 65 1.29391 36.69046 0.62811 93 0.67647 -1.06216 119.391 0.29031 0.59014
TC.KEF; monovalent cation:H+ antiporter-2, CPA2 family 0.99360 0.14904 0.88651 2.70026 0.20382 65 1.06844 4.09676 0.20988 93 0.29256 -0.62187 152.447 0.53496 0.63602
PPOX, hemY; protoporphyrinogen/coproporphyrinogen III oxidase [EC:1.3.3.4 1.3.3.15] 0.99084 0.14020 0.85900 2.02211 0.17638 65 1.08298 3.87268 0.20406 93 0.26972 -0.83043 155.806 0.40757 0.59014
vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22] 0.99079 0.13819 0.87704 2.03436 0.17691 65 1.07029 3.71838 0.19996 93 0.26698 -0.72384 155.466 0.47025 0.59353
cutC; copper homeostasis protein 0.98563 0.14506 0.82949 1.97063 0.17412 65 1.09476 4.27329 0.21436 93 0.27616 -0.96055 155.895 0.33826 0.59014
ACSS, acs; acetyl-CoA synthetase [EC:6.2.1.1] 0.98474 0.14425 0.86939 1.81708 0.16720 65 1.06537 4.33031 0.21578 93 0.27298 -0.71790 155.209 0.47390 0.59518
pcaC; 4-carboxymuconolactone decarboxylase [EC:4.1.1.44] 0.97848 0.29526 0.90154 3.88172 0.24437 65 1.03226 20.79786 0.47290 93 0.53231 -0.24557 133.963 0.80639 0.85356
nrfA; nitrite reductase (cytochrome c-552) [EC:1.7.2.2] 0.97651 0.14137 0.85444 2.10075 0.17978 65 1.06183 3.90918 0.20502 93 0.27268 -0.76057 155.617 0.44807 0.59014
nrfH; cytochrome c nitrite reductase small subunit 0.97651 0.14137 0.85444 2.10075 0.17978 65 1.06183 3.90918 0.20502 93 0.27268 -0.76057 155.617 0.44807 0.59014
tatD; TatD DNase family protein [EC:3.1.21.-] 0.97593 0.13336 0.84467 1.84709 0.16857 65 1.06767 3.48953 0.19371 93 0.25679 -0.86843 155.724 0.38650 0.59014
lemA; LemA protein 0.97009 0.13585 0.84187 1.92458 0.17207 65 1.05972 3.61748 0.19722 93 0.26174 -0.83231 155.690 0.40651 0.59014
sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5] 0.96820 0.15414 0.87154 2.79613 0.20741 65 1.03575 4.44950 0.21873 93 0.30143 -0.54478 153.468 0.58670 0.67888
sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5] 0.96820 0.15414 0.87154 2.79613 0.20741 65 1.03575 4.44950 0.21873 93 0.30143 -0.54478 153.468 0.58670 0.67888
E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72] 0.96632 0.15067 0.77026 1.49461 0.15164 65 1.10335 5.03540 0.23269 93 0.27774 -1.19929 148.289 0.23233 0.59014
gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12] 0.96549 0.14717 0.82782 2.22262 0.18492 65 1.06172 4.27066 0.21429 93 0.28305 -0.82638 155.823 0.40985 0.59014
RENBP; N-acylglucosamine 2-epimerase [EC:5.1.3.8] 0.96313 0.13569 0.83077 1.43388 0.14853 65 1.05565 3.94579 0.20598 93 0.25394 -0.88553 153.059 0.37726 0.59014
araA; L-arabinose isomerase [EC:5.3.1.4] 0.96234 0.29423 0.61615 2.50509 0.19632 65 1.20430 21.45645 0.48033 93 0.51890 -1.13346 120.471 0.25927 0.59014
araD, ulaF, sgaE, sgbE; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4] 0.96234 0.29423 0.61615 2.50509 0.19632 65 1.20430 21.45645 0.48033 93 0.51890 -1.13346 120.471 0.25927 0.59014
sacC, levB; levanase [EC:3.2.1.65] 0.95660 0.14949 0.83417 1.91419 0.17161 65 1.04216 4.67583 0.22423 93 0.28236 -0.73662 154.930 0.46247 0.59014
E3.1.21.4; type II restriction enzyme [EC:3.1.21.4] 0.95640 0.21683 0.77094 1.69015 0.16125 65 1.08602 11.46005 0.35104 93 0.38630 -0.81564 126.806 0.41624 0.59014
TPI, tpiA; triosephosphate isomerase (TIM) [EC:5.3.1.1] 0.95567 0.14137 0.82408 2.22079 0.18484 65 1.04765 3.82301 0.20275 93 0.27436 -0.81484 154.782 0.41641 0.59014
copB; Cu2+-exporting ATPase [EC:3.6.3.4] 0.95476 0.13169 0.83194 1.80421 0.16660 65 1.04060 3.40276 0.19128 93 0.25366 -0.82260 155.713 0.41199 0.59014
E2.3.1.54, pflD; formate C-acetyltransferase [EC:2.3.1.54] 0.95416 0.13648 0.83621 1.95387 0.17338 65 1.03660 3.64631 0.19801 93 0.26319 -0.76139 155.638 0.44758 0.59014
K09704; uncharacterized protein 0.95269 0.13225 0.83077 1.38056 0.14574 65 1.03790 3.73760 0.20047 93 0.24785 -0.83573 153.363 0.40461 0.59014
metF, MTHFR; methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] 0.95074 0.14143 0.80742 1.69554 0.16151 65 1.05092 4.18928 0.21224 93 0.26670 -0.91298 154.787 0.36267 0.59014
maa; maltose O-acetyltransferase [EC:2.3.1.79] 0.95002 0.15103 0.82438 2.14875 0.18182 65 1.03784 4.63628 0.22328 93 0.28794 -0.74134 155.914 0.45960 0.59014
thyA, TYMS; thymidylate synthase [EC:2.1.1.45] 0.94975 0.14176 0.85538 2.65241 0.20201 65 1.01570 3.56296 0.19573 93 0.28128 -0.56995 149.138 0.56957 0.66555
fic; cell filamentation protein 0.94843 0.13963 0.83194 2.33880 0.18969 65 1.02985 3.61389 0.19713 93 0.27357 -0.72344 152.858 0.47051 0.59353
thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2] 0.94759 0.14099 0.83917 2.06207 0.17811 65 1.02337 3.91100 0.20507 93 0.27162 -0.67813 155.749 0.49869 0.60550
xapB; MFS transporter, NHS family, xanthosine permease 0.94620 0.22482 0.96154 5.62740 0.29424 65 0.93548 9.71318 0.32318 93 0.43706 0.05961 154.818 0.95254 0.95750
K06872; uncharacterized protein 0.94536 0.23737 0.80821 4.95858 0.27620 65 1.04122 11.72081 0.35501 93 0.44980 -0.51804 155.293 0.60517 0.69179
HSP20; HSP20 family protein 0.94443 0.14656 0.80722 2.42157 0.19302 65 1.04032 4.08414 0.20956 93 0.28490 -0.81818 154.485 0.41451 0.59014
pyrP, uraA; uracil permease 0.94365 0.13585 0.82604 1.91169 0.17150 65 1.02585 3.62981 0.19756 93 0.26161 -0.76377 155.756 0.44616 0.59014
xlyAB; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] 0.94304 0.53233 0.30000 0.94375 0.12050 65 1.39247 75.25462 0.89955 93 0.90758 -1.20372 95.287 0.23168 0.59014
rlpA; rare lipoprotein A 0.94292 0.13655 0.82507 1.94114 0.17281 65 1.02529 3.66028 0.19839 93 0.26310 -0.76099 155.712 0.44781 0.59014
feoB; ferrous iron transport protein B 0.94232 0.12869 0.82610 1.75707 0.16441 65 1.02354 3.22699 0.18628 93 0.24846 -0.79468 155.509 0.42801 0.59014
oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator 0.94222 0.13609 0.82678 1.94269 0.17288 65 1.02290 3.62596 0.19746 93 0.26244 -0.74728 155.639 0.45602 0.59014
K06889; uncharacterized protein 0.94048 0.14384 0.81151 2.59305 0.19973 65 1.03062 3.75495 0.20094 93 0.28332 -0.77340 151.296 0.44049 0.59014
patB, malY; cystathione beta-lyase [EC:4.4.1.8] 0.93790 0.14370 0.79458 2.27348 0.18702 65 1.03806 3.96174 0.20640 93 0.27852 -0.87418 154.944 0.38337 0.59014
K01163; uncharacterized protein 0.93770 0.12889 0.87596 1.66601 0.16010 65 0.98085 3.31579 0.18882 93 0.24756 -0.42368 155.959 0.67238 0.75298
hcp; hydroxylamine reductase [EC:1.7.99.1] 0.93453 0.13627 0.82348 1.94746 0.17309 65 1.01215 3.63721 0.19776 93 0.26281 -0.71789 155.644 0.47390 0.59518
DHFR, folA; dihydrofolate reductase [EC:1.5.1.3] 0.93141 0.12843 0.82345 1.75378 0.16426 65 1.00686 3.21315 0.18588 93 0.24805 -0.73940 155.487 0.46078 0.59014
fldA, nifF, isiB; flavodoxin I 0.93141 0.12843 0.82345 1.75378 0.16426 65 1.00686 3.21315 0.18588 93 0.24805 -0.73940 155.487 0.46078 0.59014
GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16] 0.93141 0.12843 0.82345 1.75378 0.16426 65 1.00686 3.21315 0.18588 93 0.24805 -0.73940 155.487 0.46078 0.59014
RP-L17, MRPL17, rplQ; large subunit ribosomal protein L17 0.93141 0.12843 0.82345 1.75378 0.16426 65 1.00686 3.21315 0.18588 93 0.24805 -0.73940 155.487 0.46078 0.59014
zntA; Cd2+/Zn2+-exporting ATPase [EC:3.6.3.3 3.6.3.5] 0.93141 0.12843 0.82345 1.75378 0.16426 65 1.00686 3.21315 0.18588 93 0.24805 -0.73940 155.487 0.46078 0.59014
xanP; xanthine permease XanP 0.93081 0.14043 0.86014 2.31371 0.18867 65 0.98021 3.70162 0.19951 93 0.27459 -0.43726 153.572 0.66254 0.74343
cusA, silA; Cu(I)/Ag(I) efflux system membrane protein CusA/SilA 0.93038 0.21345 1.01538 6.32788 0.31201 65 0.87097 7.87447 0.29098 93 0.42664 0.33850 146.597 0.73547 0.79501
IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5] 0.93031 0.13799 0.81284 2.28793 0.18761 65 1.01242 3.52594 0.19471 93 0.27039 -0.73812 152.800 0.46157 0.59014
lon; ATP-dependent Lon protease [EC:3.4.21.53] 0.93031 0.13799 0.81284 2.28793 0.18761 65 1.01242 3.52594 0.19471 93 0.27039 -0.73812 152.800 0.46157 0.59014
purL, PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3] 0.93031 0.13799 0.81284 2.28793 0.18761 65 1.01242 3.52594 0.19471 93 0.27039 -0.73812 152.800 0.46157 0.59014
rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] 0.93031 0.13799 0.81284 2.28793 0.18761 65 1.01242 3.52594 0.19471 93 0.27039 -0.73812 152.800 0.46157 0.59014
URA4, pyrC; dihydroorotase [EC:3.5.2.3] 0.93031 0.13799 0.81284 2.28793 0.18761 65 1.01242 3.52594 0.19471 93 0.27039 -0.73812 152.800 0.46157 0.59014
uup; ABC transport system ATP-binding/permease protein 0.93031 0.13799 0.81284 2.28793 0.18761 65 1.01242 3.52594 0.19471 93 0.27039 -0.73812 152.800 0.46157 0.59014
pbuG; putative MFS transporter, AGZA family, xanthine/uracil permease 0.93026 0.13556 0.81311 1.90908 0.17138 65 1.01215 3.61019 0.19703 93 0.26113 -0.76223 155.731 0.44708 0.59014
ybdG, mscM; miniconductance mechanosensitive channel 0.92843 0.13560 0.80923 1.91412 0.17160 65 1.01175 3.60920 0.19700 93 0.26126 -0.77516 155.711 0.43942 0.59014
E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1] 0.92748 0.13732 0.80276 1.98606 0.17480 65 1.01465 3.68428 0.19904 93 0.26490 -0.79988 155.592 0.42500 0.59014
SLC13A2_3_5; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 0.92330 0.13956 0.81275 2.20743 0.18428 65 1.00058 3.70162 0.19951 93 0.27159 -0.69158 154.395 0.49024 0.60393
asnA; aspartate–ammonia ligase [EC:6.3.1.1] 0.92260 0.13172 0.80930 1.52721 0.15328 65 1.00179 3.60065 0.19677 93 0.24942 -0.77173 155.318 0.44145 0.59014
lolA; outer membrane lipoprotein carrier protein 0.92194 0.37171 0.55641 2.97507 0.21394 65 1.17742 35.02464 0.61368 93 0.64991 -0.95554 113.315 0.34134 0.59014
K09155; uncharacterized protein 0.92077 0.13164 0.80110 1.80337 0.16657 65 1.00442 3.40072 0.19122 93 0.25360 -0.80174 155.712 0.42393 0.59014
hppA; K(+)-stimulated pyrophosphate-energized sodium pump [EC:3.6.1.1] 0.92032 0.14160 0.79362 1.73841 0.16354 65 1.00887 4.17766 0.21195 93 0.26770 -0.80408 155.119 0.42258 0.59014
mp2; beta-1,4-mannooligosaccharide/beta-1,4-mannosyl-N-acetylglucosamine phosphorylase [EC:2.4.1.319 2.4.1.320] 0.91968 0.12914 0.79634 1.29454 0.14112 65 1.00589 3.57808 0.19615 93 0.24164 -0.86720 152.975 0.38719 0.59014
NEU1; sialidase-1 [EC:3.2.1.18] 0.91968 0.12914 0.79634 1.29454 0.14112 65 1.00589 3.57808 0.19615 93 0.24164 -0.86720 152.975 0.38719 0.59014
nadA; quinolinate synthase [EC:2.5.1.72] 0.91959 0.14626 0.82835 2.54680 0.19794 65 0.98336 3.98623 0.20703 93 0.28643 -0.54116 153.133 0.58918 0.67888
nadB; L-aspartate oxidase [EC:1.4.3.16] 0.91959 0.14626 0.82835 2.54680 0.19794 65 0.98336 3.98623 0.20703 93 0.28643 -0.54116 153.133 0.58918 0.67888
nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19] 0.91959 0.14626 0.82835 2.54680 0.19794 65 0.98336 3.98623 0.20703 93 0.28643 -0.54116 153.133 0.58918 0.67888
pncB, NAPRT1; nicotinate phosphoribosyltransferase [EC:6.3.4.21] 0.91896 0.13166 0.79725 1.80641 0.16671 65 1.00403 3.39979 0.19120 93 0.25367 -0.81516 155.699 0.41623 0.59014
PRDX2_4, ahpC; peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC:1.11.1.15] 0.91896 0.13166 0.79725 1.80641 0.16671 65 1.00403 3.39979 0.19120 93 0.25367 -0.81516 155.699 0.41623 0.59014
cbpA; curved DNA-binding protein 0.91887 0.14107 0.79716 2.05755 0.17792 65 1.00393 3.91646 0.20521 93 0.27160 -0.76130 155.771 0.44763 0.59014
K07011; uncharacterized protein 0.91831 0.13226 0.78897 1.82753 0.16768 65 1.00871 3.42549 0.19192 93 0.25485 -0.86226 155.670 0.38987 0.59014
mltD, dniR; membrane-bound lytic murein transglycosylase D [EC:4.2.2.-] 0.91720 0.13171 0.79352 1.81119 0.16693 65 1.00365 3.39889 0.19117 93 0.25379 -0.82796 155.679 0.40896 0.59014
cidA; holin-like protein 0.91642 0.13156 0.85788 1.62602 0.15816 65 0.95733 3.53175 0.19487 93 0.25098 -0.39621 155.889 0.69249 0.75849
K07085; putative transport protein 0.91574 0.12900 0.78589 1.72448 0.16288 65 1.00649 3.26720 0.18743 93 0.24832 -0.88838 155.742 0.37571 0.59014
ina; immune inhibitor A [EC:3.4.24.-] 0.91497 0.14053 0.78059 2.02659 0.17657 65 1.00889 3.89311 0.20460 93 0.27026 -0.84475 155.822 0.39955 0.59014
purT; phosphoribosylglycinamide formyltransferase 2 [EC:2.1.2.2] 0.91447 0.13111 0.81273 1.52673 0.15326 65 0.98558 3.56072 0.19567 93 0.24855 -0.69546 155.420 0.48781 0.60286
kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38] 0.91384 0.12900 0.78658 1.71297 0.16234 65 1.00278 3.27573 0.18768 93 0.24815 -0.87127 155.798 0.38495 0.59014
metK; S-adenosylmethionine synthetase [EC:2.5.1.6] 0.91384 0.12900 0.78658 1.71297 0.16234 65 1.00278 3.27573 0.18768 93 0.24815 -0.87127 155.798 0.38495 0.59014
purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14] 0.91268 0.13560 0.79756 2.08608 0.17915 65 0.99314 3.49048 0.19373 93 0.26387 -0.74121 154.361 0.45969 0.59014
UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22] 0.91268 0.13560 0.79756 2.08608 0.17915 65 0.99314 3.49048 0.19373 93 0.26387 -0.74121 154.361 0.45969 0.59014
RP-L36, MRPL36, rpmJ; large subunit ribosomal protein L36 0.91160 0.13501 0.84630 1.81642 0.16717 65 0.95725 3.64575 0.19799 93 0.25913 -0.42815 155.977 0.66913 0.75010
K07007; uncharacterized protein 0.91085 0.13488 0.79271 1.89393 0.17070 65 0.99343 3.57105 0.19596 93 0.25988 -0.77238 155.711 0.44106 0.59014
rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3] 0.90929 0.13167 0.79571 1.80479 0.16663 65 0.98867 3.40350 0.19130 93 0.25370 -0.76058 155.712 0.44806 0.59014
K08999; uncharacterized protein 0.90874 0.13082 0.79556 1.77252 0.16514 65 0.98785 3.36592 0.19024 93 0.25192 -0.76334 155.757 0.44642 0.59014
coaBC, dfp; phosphopantothenoylcysteine decarboxylase / phosphopantothenate—cysteine ligase [EC:4.1.1.36 6.3.2.5] 0.90861 0.13122 0.79736 1.80623 0.16670 65 0.98637 3.37159 0.19040 93 0.25306 -0.74686 155.640 0.45627 0.59014
panB; 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11] 0.90861 0.13122 0.79736 1.80623 0.16670 65 0.98637 3.37159 0.19040 93 0.25306 -0.74686 155.640 0.45627 0.59014
panC; pantoate–beta-alanine ligase [EC:6.3.2.1] 0.90861 0.13122 0.79736 1.80623 0.16670 65 0.98637 3.37159 0.19040 93 0.25306 -0.74686 155.640 0.45627 0.59014
panD; aspartate 1-decarboxylase [EC:4.1.1.11] 0.90861 0.13122 0.79736 1.80623 0.16670 65 0.98637 3.37159 0.19040 93 0.25306 -0.74686 155.640 0.45627 0.59014
ftsZ; cell division protein FtsZ 0.90853 0.12890 0.78271 1.72754 0.16303 65 0.99648 3.25921 0.18720 93 0.24824 -0.86115 155.715 0.39048 0.59014
rsmI; 16S rRNA (cytidine1402-2’-O)-methyltransferase [EC:2.1.1.198] 0.90849 0.12890 0.78260 1.72771 0.16303 65 0.99648 3.25921 0.18720 93 0.24824 -0.86156 155.715 0.39025 0.59014
carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5] 0.90744 0.13199 0.78642 1.82366 0.16750 65 0.99203 3.41117 0.19152 93 0.25443 -0.80811 155.655 0.42026 0.59014
kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45] 0.90740 0.13199 0.78631 1.82382 0.16751 65 0.99203 3.41117 0.19152 93 0.25444 -0.80851 155.655 0.42003 0.59014
ssb; single-strand DNA-binding protein 0.90740 0.13199 0.78631 1.82382 0.16751 65 0.99203 3.41117 0.19152 93 0.25444 -0.80851 155.655 0.42003 0.59014
glmS, GFPT; glucosamine—fructose-6-phosphate aminotransferase (isomerizing) [EC:2.6.1.16] 0.90699 0.13614 0.78071 1.91050 0.17144 65 0.99524 3.64942 0.19809 93 0.26198 -0.81890 155.792 0.41410 0.59014
lldE; L-lactate dehydrogenase complex protein LldE 0.90572 0.14000 0.78473 2.02147 0.17635 65 0.99028 3.86073 0.20375 93 0.26947 -0.76279 155.791 0.44674 0.59014
lldF; L-lactate dehydrogenase complex protein LldF 0.90572 0.14000 0.78473 2.02147 0.17635 65 0.99028 3.86073 0.20375 93 0.26947 -0.76279 155.791 0.44674 0.59014
lldG; L-lactate dehydrogenase complex protein LldG 0.90572 0.14000 0.78473 2.02147 0.17635 65 0.99028 3.86073 0.20375 93 0.26947 -0.76279 155.791 0.44674 0.59014
MMAB, pduO; cob(I)alamin adenosyltransferase [EC:2.5.1.17] 0.90565 0.13632 0.76923 1.90988 0.17141 65 1.00100 3.65956 0.19837 93 0.26217 -0.88403 155.809 0.37804 0.59014
fruA; fructan beta-fructosidase [EC:3.2.1.80] 0.90382 0.13636 0.76536 1.91458 0.17162 65 1.00060 3.65856 0.19834 93 0.26229 -0.89689 155.794 0.37116 0.59014
umuC; DNA polymerase V 0.90138 0.13197 0.80596 1.61397 0.15758 65 0.96808 3.56233 0.19572 93 0.25127 -0.64520 155.815 0.51975 0.62241
E3.1.3.48; protein-tyrosine phosphatase [EC:3.1.3.48] 0.90025 0.13104 0.77758 1.79285 0.16608 65 0.98598 3.36442 0.19020 93 0.25251 -0.82533 155.679 0.41045 0.59014
TC.BASS; bile acid:Na+ symporter, BASS family 0.89830 0.12715 0.78055 1.67955 0.16075 65 0.98061 3.17398 0.18474 93 0.24488 -0.81695 155.726 0.41521 0.59014
dapdh; diaminopimelate dehydrogenase [EC:1.4.1.16] 0.89821 0.12715 0.78033 1.67989 0.16076 65 0.98061 3.17398 0.18474 93 0.24489 -0.81781 155.725 0.41472 0.59014
K07139; uncharacterized protein 0.89821 0.12715 0.78033 1.67989 0.16076 65 0.98061 3.17398 0.18474 93 0.24489 -0.81781 155.725 0.41472 0.59014
malY, malT; maltose/moltooligosaccharide transporter 0.89821 0.12715 0.78033 1.67989 0.16076 65 0.98061 3.17398 0.18474 93 0.24489 -0.81781 155.725 0.41472 0.59014
RP-L34, MRPL34, rpmH; large subunit ribosomal protein L34 0.89821 0.12715 0.78033 1.67989 0.16076 65 0.98061 3.17398 0.18474 93 0.24489 -0.81781 155.725 0.41472 0.59014
serA, PHGDH; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] 0.89821 0.12715 0.78033 1.67989 0.16076 65 0.98061 3.17398 0.18474 93 0.24489 -0.81781 155.725 0.41472 0.59014
serC, PSAT1; phosphoserine aminotransferase [EC:2.6.1.52] 0.89821 0.12715 0.78033 1.67989 0.16076 65 0.98061 3.17398 0.18474 93 0.24489 -0.81781 155.725 0.41472 0.59014
greA; transcription elongation factor GreA 0.89740 0.12823 0.76997 1.68365 0.16094 65 0.98647 3.24299 0.18674 93 0.24652 -0.87819 155.836 0.38119 0.59014
hemD, UROS; uroporphyrinogen-III synthase [EC:4.2.1.75] 0.89736 0.12823 0.76987 1.68381 0.16095 65 0.98647 3.24299 0.18674 93 0.24653 -0.87860 155.836 0.38097 0.59014
K07000; uncharacterized protein 0.89713 0.13071 0.78429 1.77481 0.16524 65 0.97600 3.35692 0.18999 93 0.25180 -0.76138 155.732 0.44758 0.59014
coaW; type II pantothenate kinase [EC:2.7.1.33] 0.89708 0.13071 0.78418 1.77498 0.16525 65 0.97600 3.35692 0.18999 93 0.25180 -0.76181 155.731 0.44733 0.59014
E3.1.3.5; 5’-nucleotidase [EC:3.1.3.5] 0.89708 0.13071 0.78418 1.77498 0.16525 65 0.97600 3.35692 0.18999 93 0.25180 -0.76181 155.731 0.44733 0.59014
fabI; enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10] 0.89708 0.13071 0.78418 1.77498 0.16525 65 0.97600 3.35692 0.18999 93 0.25180 -0.76181 155.731 0.44733 0.59014
ftnA, ftn; ferritin [EC:1.16.3.2] 0.89708 0.13071 0.78418 1.77498 0.16525 65 0.97600 3.35692 0.18999 93 0.25180 -0.76181 155.731 0.44733 0.59014
K09125; uncharacterized protein 0.89708 0.13071 0.78418 1.77498 0.16525 65 0.97600 3.35692 0.18999 93 0.25180 -0.76181 155.731 0.44733 0.59014
menE; O-succinylbenzoic acid—CoA ligase [EC:6.2.1.26] 0.89708 0.13071 0.78418 1.77498 0.16525 65 0.97600 3.35692 0.18999 93 0.25180 -0.76181 155.731 0.44733 0.59014
pdxS, pdx1; pyridoxal 5’-phosphate synthase pdxS subunit [EC:4.3.3.6] 0.89708 0.13071 0.78418 1.77498 0.16525 65 0.97600 3.35692 0.18999 93 0.25180 -0.76181 155.731 0.44733 0.59014
pdxT, pdx2; 5’-phosphate synthase pdxT subunit [EC:4.3.3.6] 0.89708 0.13071 0.78418 1.77498 0.16525 65 0.97600 3.35692 0.18999 93 0.25180 -0.76181 155.731 0.44733 0.59014
trpF; phosphoribosylanthranilate isomerase [EC:5.3.1.24] 0.89708 0.13071 0.78418 1.77498 0.16525 65 0.97600 3.35692 0.18999 93 0.25180 -0.76181 155.731 0.44733 0.59014
zapA; cell division protein ZapA 0.89708 0.13071 0.78418 1.77498 0.16525 65 0.97600 3.35692 0.18999 93 0.25180 -0.76181 155.731 0.44733 0.59014
lipA; lipoyl synthase [EC:2.8.1.8] 0.89695 0.13680 0.77860 2.16725 0.18260 65 0.97966 3.52170 0.19460 93 0.26685 -0.75348 153.863 0.45231 0.59014
comM; magnesium chelatase family protein 0.89675 0.12737 0.77156 1.68510 0.16101 65 0.98424 3.18329 0.18501 93 0.24526 -0.86714 155.724 0.38720 0.59014
ATPF1A, atpA; F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14] 0.89670 0.12737 0.77146 1.68526 0.16102 65 0.98424 3.18329 0.18501 93 0.24527 -0.86755 155.723 0.38697 0.59014
ppnN; pyrimidine/purine-5’-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-] 0.89528 0.13334 0.75505 1.82431 0.16753 65 0.99328 3.50140 0.19403 93 0.25635 -0.92929 155.818 0.35418 0.59014
pabB; para-aminobenzoate synthetase component I [EC:2.6.1.85] 0.88973 0.14169 0.80853 2.36590 0.19078 65 0.94648 3.75928 0.20105 93 0.27717 -0.49771 153.439 0.61940 0.70276
pabC; 4-amino-4-deoxychorismate lyase [EC:4.1.3.38] 0.88973 0.14169 0.80853 2.36590 0.19078 65 0.94648 3.75928 0.20105 93 0.27717 -0.49771 153.439 0.61940 0.70276
ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25] 0.88754 0.12713 0.76987 1.68381 0.16095 65 0.96978 3.16970 0.18462 93 0.24492 -0.81623 155.700 0.41562 0.59014
ogt, MGMT; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 0.88753 0.12961 0.80769 1.97763 0.17443 65 0.94332 3.14608 0.18393 93 0.25348 -0.53507 153.462 0.59337 0.68100
yjbB; phosphate:Na+ symporter 0.88736 0.12712 0.76997 1.68365 0.16094 65 0.96941 3.16936 0.18461 93 0.24491 -0.81432 155.700 0.41670 0.59014
AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ABC.FEV.A; iron complex transport system ATP-binding protein [EC:3.6.3.34] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ABC.FEV.P; iron complex transport system permease protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ABC.FEV.S; iron complex transport system substrate-binding protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ABC.SN.S; NitT/TauT family transport system substrate-binding protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ABCF3; ATP-binding cassette, subfamily F, member 3 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ackA; acetate kinase [EC:2.7.2.1] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
adk, AK; adenylate kinase [EC:2.7.4.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
aguB; N-carbamoylputrescine amidase [EC:3.5.1.53] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
AIBP, nnrE; NAD(P)H-hydrate epimerase [EC:5.1.99.6] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
alr; alanine racemase [EC:5.1.1.1] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
apbE; FAD:protein FMN transferase [EC:2.7.1.180] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
APRT, apt; adenine phosphoribosyltransferase [EC:2.4.2.7] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
argR, ahrC; transcriptional regulator of arginine metabolism 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
AROA1, aroA; chorismate mutase [EC:5.4.99.5] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
aroB; 3-dehydroquinate synthase [EC:4.2.3.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
aroC; chorismate synthase [EC:4.2.3.5] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
aroE; shikimate dehydrogenase [EC:1.1.1.25] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
aspS; aspartyl-tRNA synthetase [EC:6.1.1.12] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ATPF0A, atpB; F-type H+-transporting ATPase subunit a 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ATPF0B, atpF; F-type H+-transporting ATPase subunit b 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ATPF0C, atpE; F-type H+-transporting ATPase subunit c 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ATPF1B, atpD; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ATPF1D, atpH; F-type H+-transporting ATPase subunit delta 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ATPF1E, atpC; F-type H+-transporting ATPase subunit epsilon 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ATPF1G, atpG; F-type H+-transporting ATPase subunit gamma 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
bamD; outer membrane protein assembly factor BamD 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
BCP, PRXQ, DOT5; peroxiredoxin Q/BCP [EC:1.11.1.15] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
birA; BirA family transcriptional regulator, biotin operon repressor / biotin—[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
cdd, CDA; cytidine deaminase [EC:3.5.4.5] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
CHO1, pssA; CDP-diacylglycerol—serine O-phosphatidyltransferase [EC:2.7.8.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
clpB; ATP-dependent Clp protease ATP-binding subunit ClpB 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
clpC; ATP-dependent Clp protease ATP-binding subunit ClpC 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
clpX, CLPX; ATP-dependent Clp protease ATP-binding subunit ClpX 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
cmk; CMP/dCMP kinase [EC:2.7.4.25] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
comEB; dCMP deaminase [EC:3.5.4.12] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
comEC; competence protein ComEC 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
corA; magnesium transporter 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
cydA; cytochrome bd ubiquinol oxidase subunit I [EC:1.10.3.14] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
cydB; cytochrome bd ubiquinol oxidase subunit II [EC:1.10.3.14] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
deaD, cshA; ATP-dependent RNA helicase DeaD [EC:3.6.4.13] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
deoC, DERA; deoxyribose-phosphate aldolase [EC:4.1.2.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dgt; dGTPase [EC:3.1.5.1] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dinB; DNA polymerase IV [EC:2.7.7.7] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dnaA; chromosomal replication initiator protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dnaB; replicative DNA helicase [EC:3.6.4.12] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dnaG; DNA primase [EC:2.7.7.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dnaJ; molecular chaperone DnaJ 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dnaK, HSPA9; molecular chaperone DnaK 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
DPP3; dipeptidyl-peptidase III [EC:3.4.14.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dsbD; thiol:disulfide interchange protein DsbD [EC:1.8.1.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dtd, DTD1; D-tyrosyl-tRNA(Tyr) deacylase [EC:3.1.-.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
dxr; 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E1.1.1.40, maeB; malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E2.3.1.8, pta; phosphate acetyltransferase [EC:2.3.1.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E2.7.1.71, aroK, aroL; shikimate kinase [EC:2.7.1.71] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E2.7.4.8, gmk; guanylate kinase [EC:2.7.4.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E2.7.7.24, rfbA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E2.7.7.3A, coaD, kdtB; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E3.2.1.1A; alpha-amylase [EC:3.2.1.1] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E3.6.1.22, NUDT12, nudC; NAD+ diphosphatase [EC:3.6.1.22] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E4.1.1.49, pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E4.2.1.2A, fumA, fumB; fumarate hydratase, class I [EC:4.2.1.2] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E4.2.1.46, rfbB, rffG; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E4.3.1.17, sdaA, sdaB, tdcG; L-serine dehydratase [EC:4.3.1.17] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E6.3.5.1, NADSYN1, QNS1, nadE; NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
efp; elongation factor P 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
engA, der; GTPase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
engB; GTP-binding protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ENO, eno; enolase [EC:4.2.1.11] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
entC; isochorismate synthase [EC:5.4.4.2] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
era, ERAL1; GTPase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
fbp3; fructose-1,6-bisphosphatase III [EC:3.1.3.11] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
fixA, etfB; electron transfer flavoprotein beta subunit 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
fixB, etfA; electron transfer flavoprotein alpha subunit 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:4.1.2.25 5.1.99.8 1.13.11.81] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
folP; dihydropteroate synthase [EC:2.5.1.15] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
frr, MRRF, RRF; ribosome recycling factor 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ftsA; cell division protein FtsA 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ftsE; cell division transport system ATP-binding protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ftsH, hflB; cell division protease FtsH [EC:3.4.24.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ftsK, spoIIIE; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ftsQ; cell division protein FtsQ 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ftsW, spoVE; cell division protein FtsW 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ftsX; cell division transport system permease protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ftsY; fused signal recognition particle receptor 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
galE, GALE; UDP-glucose 4-epimerase [EC:5.1.3.2] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
GARS, glyS1; glycyl-tRNA synthetase [EC:6.1.1.14] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
GBE1, glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
gcpE, ispG; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
gidA, mnmG, MTO1; tRNA uridine 5-carboxymethylaminomethyl modification enzyme 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
glgA; starch synthase [EC:2.4.1.21] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
gmd, GMDS; GDPmannose 4,6-dehydratase [EC:4.2.1.47] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
GPI, pgi; glucose-6-phosphate isomerase [EC:5.3.1.9] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
groEL, HSPD1; chaperonin GroEL 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
groES, HSPE1; chaperonin GroES 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
GRPE; molecular chaperone GrpE 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
gyrA; DNA gyrase subunit A [EC:5.99.1.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
gyrB; DNA gyrase subunit B [EC:5.99.1.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
hemK, prmC, HEMK; release factor glutamine methyltransferase [EC:2.1.1.297] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
hflX; GTPase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
HINT1, hinT, hit; histidine triad (HIT) family protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
holA; DNA polymerase III subunit delta [EC:2.7.7.7] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
holB; DNA polymerase III subunit delta’ [EC:2.7.7.7] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
hprA; glycerate dehydrogenase [EC:1.1.1.29] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
hslR; ribosome-associated heat shock protein Hsp15 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
HSP90A, htpG; molecular chaperone HtpG 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
infA; translation initiation factor IF-1 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
infB, MTIF2; translation initiation factor IF-2 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
infC, MTIF3; translation initiation factor IF-3 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ispB; octaprenyl-diphosphate synthase [EC:2.5.1.90] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ispH, lytB; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
K00243; uncharacterized protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
K06890; uncharacterized protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
K07027; glycosyltransferase 2 family protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
K07037; uncharacterized protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
K07082; UPF0755 protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
K07137; uncharacterized protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
K07164; uncharacterized protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
K09861; uncharacterized protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
KAE1, tsaD, QRI7; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
kdsD, kpsF; arabinose-5-phosphate isomerase [EC:5.3.1.13] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
kdtA, waaA; 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.4.99.12 2.4.99.13 2.4.99.14 2.4.99.15] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
korC, oorC; 2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
korD, oorD; 2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
lepA; GTP-binding protein LepA 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
lolD; lipoprotein-releasing system ATP-binding protein [EC:3.6.3.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
lptB; lipopolysaccharide export system ATP-binding protein [EC:3.6.3.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
lptF; lipopolysaccharide export system permease protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
lptG; lipopolysaccharide export system permease protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
lpxC-fabZ; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
lpxH; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
lpxK; tetraacyldisaccharide 4’-kinase [EC:2.7.1.130] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
lpxL, htrB; Kdo2-lipid IVA lauroyltransferase [EC:2.3.1.241] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
lspA; signal peptidase II [EC:3.4.23.36] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
lysC; aspartate kinase [EC:2.7.2.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
maf; septum formation protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
malQ; 4-alpha-glucanotransferase [EC:2.4.1.25] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
manA, MPI; mannose-6-phosphate isomerase [EC:5.3.1.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
manB; phosphomannomutase [EC:5.4.2.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mdh; malate dehydrogenase [EC:1.1.1.37] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
menA; 1,4-dihydroxy-2-naphthoate octaprenyltransferase [EC:2.5.1.74 2.5.1.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
menB; naphthoate synthase [EC:4.1.3.36] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
menD; 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [EC:2.2.1.9] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mfd; transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mlaD, linM; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mlaE, linK; phospholipid/cholesterol/gamma-HCH transport system permease protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mlaF, linL, mkl; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mnmA, trmU; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
motB; chemotaxis protein MotB 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mraW, rsmH; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mreB; rod shape-determining protein MreB and related proteins 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mreC; rod shape-determining protein MreC 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mrp, NUBPL; ATP-binding protein involved in chromosome partitioning 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:3.6.3.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mscL; large conductance mechanosensitive channel 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mtgA; monofunctional glycosyltransferase [EC:2.4.1.129] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mtnN, mtn, pfs; adenosylhomocysteine nucleosidase [EC:3.2.2.9] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
murC; UDP-N-acetylmuramate–alanine ligase [EC:6.3.2.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
murD; UDP-N-acetylmuramoylalanine–D-glutamate ligase [EC:6.3.2.9] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase [EC:6.3.2.13] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
murF; UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase [EC:6.3.2.10] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
murG; UDP-N-acetylglucosamine–N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
murI; glutamate racemase [EC:5.1.1.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mutL; DNA mismatch repair protein MutL 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mutS; DNA mismatch repair protein MutS 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mutS2; DNA mismatch repair protein MutS2 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nfrA2; FMN reductase [NAD(P)H] [EC:1.5.1.39] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nqrA; Na+-transporting NADH:ubiquinone oxidoreductase subunit A [EC:1.6.5.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nqrB; Na+-transporting NADH:ubiquinone oxidoreductase subunit B [EC:1.6.5.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nqrC; Na+-transporting NADH:ubiquinone oxidoreductase subunit C [EC:1.6.5.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nqrD; Na+-transporting NADH:ubiquinone oxidoreductase subunit D [EC:1.6.5.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nqrE; Na+-transporting NADH:ubiquinone oxidoreductase subunit E [EC:1.6.5.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nqrF; Na+-transporting NADH:ubiquinone oxidoreductase subunit F [EC:1.6.5.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nspC; carboxynorspermidine decarboxylase [EC:4.1.1.96] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
NTH; endonuclease III [EC:4.2.99.18] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nuoA; NADH-quinone oxidoreductase subunit A [EC:1.6.5.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nuoB; NADH-quinone oxidoreductase subunit B [EC:1.6.5.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nuoCD; NADH-quinone oxidoreductase subunit C/D [EC:1.6.5.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nuoH; NADH-quinone oxidoreductase subunit H [EC:1.6.5.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nuoI; NADH-quinone oxidoreductase subunit I [EC:1.6.5.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nuoJ; NADH-quinone oxidoreductase subunit J [EC:1.6.5.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nuoK; NADH-quinone oxidoreductase subunit K [EC:1.6.5.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nuoL; NADH-quinone oxidoreductase subunit L [EC:1.6.5.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nuoM; NADH-quinone oxidoreductase subunit M [EC:1.6.5.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nuoN; NADH-quinone oxidoreductase subunit N [EC:1.6.5.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nupG; MFS transporter, NHS family, nucleoside permease 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nusA; N utilization substance protein A 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nusB; N utilization substance protein B 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
nusG; transcriptional antiterminator NusG 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
obgE, cgtA; GTPase [EC:3.6.5.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
parB, spo0J; chromosome partitioning protein, ParB family 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
parC; topoisomerase IV subunit A [EC:5.99.1.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
parE; topoisomerase IV subunit B [EC:5.99.1.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
PDF, def; peptide deformylase [EC:3.5.1.88] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pdxA; 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pepT; tripeptide aminopeptidase [EC:3.4.11.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pfp, PFP; diphosphate-dependent phosphofructokinase [EC:2.7.1.90] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pgm; phosphoglucomutase [EC:5.4.2.2] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
phnP; phosphoribosyl 1,2-cyclic phosphate phosphodiesterase [EC:3.1.4.55] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
phoH, phoL; phosphate starvation-inducible protein PhoH and related proteins 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
PK, pyk; pyruvate kinase [EC:2.7.1.40] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pnuC; nicotinamide mononucleotide transporter 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
polA; DNA polymerase I [EC:2.7.7.7] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
por, nifJ; pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ppnK, NADK; NAD+ kinase [EC:2.7.1.23] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
prfA, MTRF1, MRF1; peptide chain release factor 1 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
prfB; peptide chain release factor 2 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
prfC; peptide chain release factor 3 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
priA; primosomal protein N’ (replication factor Y) (superfamily II helicase) [EC:3.6.4.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pstS; phosphate transport system substrate-binding protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
PTH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
punA, PNP; purine-nucleoside phosphorylase [EC:2.4.2.1] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
purB, ADSL; adenylosuccinate lyase [EC:4.3.2.2] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
purD; phosphoribosylamine—glycine ligase [EC:6.3.4.13] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pycB; pyruvate carboxylase subunit B [EC:6.4.1.1] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
PYG, glgP; glycogen phosphorylase [EC:2.4.1.1] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pyrB, PYR2; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pyrDII; dihydroorotate dehydrogenase electron transfer subunit 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pyrF; orotidine-5’-phosphate decarboxylase [EC:4.1.1.23] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pyrG, CTPS; CTP synthase [EC:6.3.4.2] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pyrH; uridylate kinase [EC:2.7.4.22] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
pyrI; aspartate carbamoyltransferase regulatory subunit 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
QARS, glnS; glutaminyl-tRNA synthetase [EC:6.1.1.18] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
queG; epoxyqueuosine reductase [EC:1.17.99.6] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
radC; DNA repair protein RadC 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rbfA; ribosome-binding factor A 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
recA; recombination protein RecA 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
recF; DNA replication and repair protein RecF 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
recN; DNA repair protein RecN (Recombination protein N) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
recO; DNA repair protein RecO (recombination protein O) 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
recR; recombination protein RecR 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
recX; regulatory protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rfbC, rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rfbD, rmlD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rho; transcription termination factor Rho 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ribE, RIB5; riboflavin synthase [EC:2.5.1.9] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ribH, RIB4; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ridA, tdcF, RIDA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rimM; 16S rRNA processing protein RimM 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rimP; ribosome maturation factor RimP 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rmuC; DNA recombination protein RmuC 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rng, cafA; ribonuclease G [EC:3.1.26.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rnhB; ribonuclease HII [EC:3.1.26.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rnpA; ribonuclease P protein component [EC:3.1.26.5] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rnr, vacB; ribonuclease R [EC:3.1.-.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rny; ribonucrease Y [EC:3.1.-.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rnz; ribonuclease Z [EC:3.1.26.11] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rodA, mrdB; rod shape determining protein RodA 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L1, MRPL1, rplA; large subunit ribosomal protein L1 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L10, MRPL10, rplJ; large subunit ribosomal protein L10 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L11, MRPL11, rplK; large subunit ribosomal protein L11 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L13, MRPL13, rplM; large subunit ribosomal protein L13 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L14, MRPL14, rplN; large subunit ribosomal protein L14 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L15, MRPL15, rplO; large subunit ribosomal protein L15 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L16, MRPL16, rplP; large subunit ribosomal protein L16 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L18, MRPL18, rplR; large subunit ribosomal protein L18 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L19, MRPL19, rplS; large subunit ribosomal protein L19 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L2, MRPL2, rplB; large subunit ribosomal protein L2 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L20, MRPL20, rplT; large subunit ribosomal protein L20 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L21, MRPL21, rplU; large subunit ribosomal protein L21 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L22, MRPL22, rplV; large subunit ribosomal protein L22 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L23, MRPL23, rplW; large subunit ribosomal protein L23 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L24, MRPL24, rplX; large subunit ribosomal protein L24 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L25, rplY; large subunit ribosomal protein L25 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L27, MRPL27, rpmA; large subunit ribosomal protein L27 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L28, MRPL28, rpmB; large subunit ribosomal protein L28 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L29, rpmC; large subunit ribosomal protein L29 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L3, MRPL3, rplC; large subunit ribosomal protein L3 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L30, MRPL30, rpmD; large subunit ribosomal protein L30 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L31, rpmE; large subunit ribosomal protein L31 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L32, MRPL32, rpmF; large subunit ribosomal protein L32 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L33, MRPL33, rpmG; large subunit ribosomal protein L33 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L35, MRPL35, rpmI; large subunit ribosomal protein L35 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L4, MRPL4, rplD; large subunit ribosomal protein L4 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L5, MRPL5, rplE; large subunit ribosomal protein L5 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L6, MRPL6, rplF; large subunit ribosomal protein L6 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L7, MRPL12, rplL; large subunit ribosomal protein L7/L12 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-L9, MRPL9, rplI; large subunit ribosomal protein L9 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S1, rpsA; small subunit ribosomal protein S1 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S10, MRPS10, rpsJ; small subunit ribosomal protein S10 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S11, MRPS11, rpsK; small subunit ribosomal protein S11 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S13, rpsM; small subunit ribosomal protein S13 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S14, MRPS14, rpsN; small subunit ribosomal protein S14 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S15, MRPS15, rpsO; small subunit ribosomal protein S15 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S16, MRPS16, rpsP; small subunit ribosomal protein S16 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S17, MRPS17, rpsQ; small subunit ribosomal protein S17 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S19, rpsS; small subunit ribosomal protein S19 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S20, rpsT; small subunit ribosomal protein S20 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S21, MRPS21, rpsU; small subunit ribosomal protein S21 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S3, rpsC; small subunit ribosomal protein S3 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S4, rpsD; small subunit ribosomal protein S4 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S5, MRPS5, rpsE; small subunit ribosomal protein S5 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S7, MRPS7, rpsG; small subunit ribosomal protein S7 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S8, rpsH; small subunit ribosomal protein S8 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
RP-S9, MRPS9, rpsI; small subunit ribosomal protein S9 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rpe, RPE; ribulose-phosphate 3-epimerase [EC:5.1.3.1] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rpoC; DNA-directed RNA polymerase subunit beta’ [EC:2.7.7.6] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rpoN; RNA polymerase sigma-54 factor 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rseP; regulator of sigma E protease [EC:3.4.24.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rtpR; ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ruvA; holliday junction DNA helicase RuvA [EC:3.6.4.12] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ruvB; holliday junction DNA helicase RuvB [EC:3.6.4.12] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ruvX; putative holliday junction resolvase [EC:3.1.-.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
SAM50, TOB55, bamA; outer membrane protein insertion porin family 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
sdhA, frdA; succinate dehydrogenase / fumarate reductase, flavoprotein subunit [EC:1.3.5.1 1.3.5.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
sdhB, frdB; succinate dehydrogenase / fumarate reductase, iron-sulfur subunit [EC:1.3.5.1 1.3.5.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
sdhC, frdC; succinate dehydrogenase / fumarate reductase, cytochrome b subunit 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
secA; preprotein translocase subunit SecA 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
secDF; SecD/SecF fusion protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
secG; preprotein translocase subunit SecG 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
secY; preprotein translocase subunit SecY 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
slyD; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
smf; DNA processing protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
smpB; SsrA-binding protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
speA; arginine decarboxylase [EC:4.1.1.19] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
speG, SAT; diamine N-acetyltransferase [EC:2.3.1.57] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
spoU; RNA methyltransferase, TrmH family 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
sppA; protease IV [EC:3.4.21.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
sufB; Fe-S cluster assembly protein SufB 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
sufC; Fe-S cluster assembly ATP-binding protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
sufD; Fe-S cluster assembly protein SufD 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
sufE; cysteine desulfuration protein SufE 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
surE; 5’-nucleotidase [EC:3.1.3.5] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
tadA; tRNA(adenine34) deaminase [EC:3.5.4.33] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
TC.CIC; chloride channel protein, CIC family 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
TC.POT; proton-dependent oligopeptide transporter, POT family 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
tdk, TK; thymidine kinase [EC:2.7.1.21] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
tgt, QTRT1; queuine tRNA-ribosyltransferase [EC:2.4.2.29] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
thiJ; protein deglycase [EC:3.5.1.124] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
thiL; thiamine-monophosphate kinase [EC:2.7.4.16] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
tig; trigger factor 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
topA; DNA topoisomerase I [EC:5.99.1.2] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
trkA, ktrA; trk system potassium uptake protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
trkH, trkG, ktrB; trk system potassium uptake protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
trmB, METTL1; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
truA, PUS1; tRNA pseudouridine38-40 synthase [EC:5.4.99.12] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
truB, PUS4, TRUB1; tRNA pseudouridine55 synthase [EC:5.4.99.25] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
trxA; thioredoxin 1 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
tsaC, rimN, SUA5; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
tsf, TSFM; elongation factor Ts 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
TSTA3, fcl; GDP-L-fucose synthase [EC:1.1.1.271] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
tuf, TUFM; elongation factor Tu 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
typA, bipA; GTP-binding protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
udp, UPP; uridine phosphorylase [EC:2.4.2.3] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
uvrB; excinuclease ABC subunit B 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
uvrC; excinuclease ABC subunit C 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
xerC; integrase/recombinase XerC 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
xerD; integrase/recombinase XerD 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
yajC; preprotein translocase subunit YajC 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ybeB; ribosome-associated protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ycaJ; putative ATPase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ychF; ribosome-binding ATPase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
yfiC, trmX; tRNA1Val (adenine37-N6)-methyltransferase [EC:2.1.1.223] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
yfiH; polyphenol oxidase [EC:1.10.3.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
yggS, PROSC; PLP dependent protein 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-] 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
yraN; putative endonuclease 0.88732 0.12712 0.76987 1.68381 0.16095 65 0.96941 3.16936 0.18461 93 0.24492 -0.81474 155.700 0.41647 0.59014
lctP; lactate permease 0.88713 0.23359 0.74103 4.88458 0.27413 65 0.98925 11.28913 0.34841 93 0.44332 -0.55991 155.500 0.57635 0.67167
gpmB; probable phosphoglycerate mutase [EC:5.4.2.12] 0.88413 0.13159 0.75168 1.77177 0.16510 65 0.97670 3.41497 0.19163 93 0.25294 -0.88963 155.839 0.37504 0.59014
mraZ; MraZ protein 0.88413 0.13159 0.75168 1.77177 0.16510 65 0.97670 3.41497 0.19163 93 0.25294 -0.88963 155.839 0.37504 0.59014
pulA; pullulanase [EC:3.2.1.41] 0.88296 0.13528 0.75567 1.87450 0.16982 65 0.97192 3.61109 0.19705 93 0.26013 -0.83133 155.837 0.40706 0.59014
fhs; formate–tetrahydrofolate ligase [EC:6.3.4.3] 0.87335 0.13145 0.74187 1.77574 0.16528 65 0.96525 3.40283 0.19128 93 0.25280 -0.88361 155.809 0.37827 0.59014
luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21] 0.87335 0.13145 0.74187 1.77574 0.16528 65 0.96525 3.40283 0.19128 93 0.25280 -0.88361 155.809 0.37827 0.59014
npdA; NAD-dependent deacetylase [EC:3.5.1.-] 0.87335 0.13145 0.74187 1.77574 0.16528 65 0.96525 3.40283 0.19128 93 0.25280 -0.88361 155.809 0.37827 0.59014
yhbH; putative sigma-54 modulation protein 0.87335 0.13145 0.74187 1.77574 0.16528 65 0.96525 3.40283 0.19128 93 0.25280 -0.88361 155.809 0.37827 0.59014
TC.ZIP, zupT, ZRT3, ZIP2; zinc transporter, ZIP family 0.87071 0.23720 0.74725 6.72689 0.32170 65 0.95699 10.47284 0.33558 93 0.46487 -0.45117 153.020 0.65250 0.73430
DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4] 0.87053 0.13523 0.77525 2.16160 0.18236 65 0.93712 3.41585 0.19165 93 0.26455 -0.61187 153.329 0.54153 0.63858
gcvH, GCSH; glycine cleavage system H protein 0.87053 0.13523 0.77525 2.16160 0.18236 65 0.93712 3.41585 0.19165 93 0.26455 -0.61187 153.329 0.54153 0.63858
gcvPA; glycine dehydrogenase subunit 1 [EC:1.4.4.2] 0.87053 0.13523 0.77525 2.16160 0.18236 65 0.93712 3.41585 0.19165 93 0.26455 -0.61187 153.329 0.54153 0.63858
gcvPB; glycine dehydrogenase subunit 2 [EC:1.4.4.2] 0.87053 0.13523 0.77525 2.16160 0.18236 65 0.93712 3.41585 0.19165 93 0.26455 -0.61187 153.329 0.54153 0.63858
gcvT, AMT; aminomethyltransferase [EC:2.1.2.10] 0.87053 0.13523 0.77525 2.16160 0.18236 65 0.93712 3.41585 0.19165 93 0.26455 -0.61187 153.329 0.54153 0.63858
yrbG; cation:H+ antiporter 0.85430 0.12458 0.77723 1.82080 0.16737 65 0.90817 2.91077 0.17691 93 0.24354 -0.53766 153.557 0.59159 0.68001
hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3] 0.85248 0.13447 0.71933 1.76907 0.16497 65 0.94554 3.62356 0.19739 93 0.25725 -0.87930 155.999 0.38059 0.59014
cynR; LysR family transcriptional regulator, cyn operon transcriptional activator 0.85190 0.20611 0.69275 3.64304 0.23674 65 0.96313 8.88993 0.30918 93 0.38941 -0.69436 154.942 0.48850 0.60307
E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] 0.85074 0.11871 0.78974 1.37919 0.14567 65 0.89337 2.83584 0.17462 93 0.22740 -0.45570 156.000 0.64924 0.73135
TC.NSS; neurotransmitter:Na+ symporter, NSS family 0.84059 0.12909 0.72406 1.43319 0.14849 65 0.92204 3.47976 0.19343 93 0.24386 -0.81190 155.002 0.41809 0.59014
galK; galactokinase [EC:2.7.1.6] 0.84006 0.10980 0.73174 1.12392 0.13150 65 0.91577 2.45463 0.16246 93 0.20901 -0.88050 155.866 0.37994 0.59014
K08998; uncharacterized protein 0.84006 0.10980 0.73174 1.12392 0.13150 65 0.91577 2.45463 0.16246 93 0.20901 -0.88050 155.866 0.37994 0.59014
K09924; uncharacterized protein 0.82505 0.19910 0.69341 3.57425 0.23450 65 0.91705 8.18149 0.29660 93 0.37810 -0.59149 155.578 0.55505 0.65055
trpG; anthranilate synthase component II [EC:4.1.3.27] 0.82455 0.12974 0.74500 1.98318 0.17467 65 0.88015 3.15142 0.18408 93 0.25377 -0.53259 153.440 0.59509 0.68219
secE; preprotein translocase subunit SecE 0.82271 0.11954 0.72024 1.54410 0.15413 65 0.89433 2.76620 0.17246 93 0.23130 -0.75269 155.268 0.45277 0.59014
E3.6.3.8; Ca2+-transporting ATPase [EC:3.6.3.8] 0.82149 0.11978 0.74746 1.68326 0.16092 65 0.87324 2.69117 0.17011 93 0.23417 -0.53717 153.559 0.59193 0.68001
xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22] 0.82149 0.11978 0.74746 1.68326 0.16092 65 0.87324 2.69117 0.17011 93 0.23417 -0.53717 153.559 0.59193 0.68001
K07001; NTE family protein 0.82033 0.12053 0.68282 1.23652 0.13793 65 0.91644 3.03441 0.18063 93 0.22727 -1.02795 154.873 0.30558 0.59014
ndh; NADH dehydrogenase [EC:1.6.99.3] 0.81739 0.11537 0.71828 1.18617 0.13509 65 0.88667 2.75203 0.17202 93 0.21872 -0.76987 155.467 0.44254 0.59014
abfA; alpha-N-arabinofuranosidase [EC:3.2.1.55] 0.81190 0.23710 0.51200 1.60636 0.15720 65 1.02151 13.93258 0.38706 93 0.41776 -1.21960 120.156 0.22500 0.59014
K09955; uncharacterized protein 0.81190 0.23710 0.51200 1.60636 0.15720 65 1.02151 13.93258 0.38706 93 0.41776 -1.21960 120.156 0.22500 0.59014
exuT; MFS transporter, ACS family, hexuronate transporter 0.81165 0.23711 0.51138 1.60692 0.15723 65 1.02151 13.93258 0.38706 93 0.41777 -1.22105 120.165 0.22446 0.59014
TC.SSS; solute:Na+ symporter, SSS family 0.81165 0.23711 0.51138 1.60692 0.15723 65 1.02151 13.93258 0.38706 93 0.41777 -1.22105 120.165 0.22446 0.59014
uxuA; mannonate dehydratase [EC:4.2.1.8] 0.81165 0.23711 0.51138 1.60692 0.15723 65 1.02151 13.93258 0.38706 93 0.41777 -1.22105 120.165 0.22446 0.59014
djlA; DnaJ like chaperone protein 0.81110 0.12860 0.72962 1.94256 0.17287 65 0.86806 3.09963 0.18256 93 0.25143 -0.55062 153.521 0.58269 0.67611
mgtC; putative Mg2+ transporter-C (MgtC) family protein 0.80820 0.12061 0.67897 1.25391 0.13889 65 0.89852 3.02985 0.18050 93 0.22775 -0.96398 155.058 0.33655 0.59014
perR; Fur family transcriptional regulator, peroxide stress response regulator 0.80322 0.12456 0.71520 1.82770 0.16769 65 0.86473 2.90274 0.17667 93 0.24358 -0.61389 153.429 0.54020 0.63858
xylB, XYLB; xylulokinase [EC:2.7.1.17] 0.79873 0.22090 0.55949 2.78800 0.20710 65 0.96595 11.14889 0.34624 93 0.40345 -1.00746 143.250 0.31541 0.59014
cysK; cysteine synthase A [EC:2.5.1.47] 0.78473 0.11908 0.66808 1.20008 0.13588 65 0.86626 2.97209 0.17877 93 0.22455 -0.88261 154.757 0.37882 0.59014
arnE; undecaprenyl phosphate-alpha-L-ara4N flippase subunit ArnE 0.78165 0.20123 0.49487 1.34720 0.14397 65 0.98208 9.88253 0.32598 93 0.35636 -1.36719 124.575 0.17403 0.59014
trpB; tryptophan synthase beta chain [EC:4.2.1.20] 0.77916 0.11350 0.67658 1.26594 0.13956 65 0.85086 2.58026 0.16657 93 0.21730 -0.80199 155.997 0.42378 0.59014
lysA; diaminopimelate decarboxylase [EC:4.1.1.20] 0.77790 0.11572 0.65612 1.15146 0.13310 65 0.86301 2.79168 0.17326 93 0.21848 -0.94695 155.019 0.34514 0.59014
metA; homoserine O-succinyltransferase/O-acetyltransferase [EC:2.3.1.46 2.3.1.31] 0.77790 0.11572 0.65612 1.15146 0.13310 65 0.86301 2.79168 0.17326 93 0.21848 -0.94695 155.019 0.34514 0.59014
thrA; bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3] 0.77790 0.11572 0.65612 1.15146 0.13310 65 0.86301 2.79168 0.17326 93 0.21848 -0.94695 155.019 0.34514 0.59014
K07504; predicted type IV restriction endonuclease 0.77532 0.18790 0.80000 4.34219 0.25846 65 0.75806 6.49790 0.26433 93 0.36969 0.11343 152.123 0.90984 0.94278
norB; nitric oxide reductase subunit B [EC:1.7.2.5] 0.77532 0.18790 0.80000 4.34219 0.25846 65 0.75806 6.49790 0.26433 93 0.36969 0.11343 152.123 0.90984 0.94278
TC.FEV.OM3, tbpA, hemR, lbpA, hpuB, bhuR, hugA, hmbR; hemoglobin/transferrin/lactoferrin receptor protein 0.77532 0.18790 0.80000 4.34219 0.25846 65 0.75806 6.49790 0.26433 93 0.36969 0.11343 152.123 0.90984 0.94278
fadL; long-chain fatty acid transport protein 0.77342 0.20157 0.50564 1.33280 0.14319 65 0.96057 9.94227 0.32697 93 0.35695 -1.27451 124.112 0.20486 0.59014
penP; beta-lactamase class A [EC:3.5.2.6] 0.76582 0.21622 0.63590 1.76640 0.16485 65 0.85663 11.35603 0.34944 93 0.38637 -0.57130 128.367 0.56880 0.66532
MuB; ATP-dependent target DNA activator [EC:3.6.1.3] 0.75949 0.33255 0.64615 21.03690 0.56890 65 0.83871 15.16935 0.40387 93 0.69768 -0.27599 123.027 0.78302 0.83724
pspC; phage shock protein C 0.75105 0.19464 0.57094 1.88653 0.17036 65 0.87694 8.86405 0.30873 93 0.35261 -0.86781 138.146 0.38700 0.59014
AXY8, FUC95A, afcA; alpha-L-fucosidase 2 [EC:3.2.1.51] 0.74549 0.10071 0.67590 1.06265 0.12786 65 0.79413 1.98973 0.14627 93 0.19428 -0.60858 155.663 0.54369 0.64048
gpr; L-glyceraldehyde 3-phosphate reductase [EC:1.1.1.-] 0.74367 0.19057 0.82308 4.43305 0.26115 65 0.68817 6.70062 0.26842 93 0.37450 0.36023 152.361 0.71918 0.78345
cytR; LacI family transcriptional regulator, repressor for deo operon, udp, cdd, tsx, nupC, and nupG 0.73418 0.49184 0.80000 41.60000 0.80000 65 0.68817 36.28214 0.62460 93 1.01495 0.11018 131.751 0.91243 0.94278
GBA, srfJ; glucosylceramidase [EC:3.2.1.45] 0.73418 0.49184 0.80000 41.60000 0.80000 65 0.68817 36.28214 0.62460 93 1.01495 0.11018 131.751 0.91243 0.94278
K09973; uncharacterized protein 0.73418 0.49184 0.80000 41.60000 0.80000 65 0.68817 36.28214 0.62460 93 1.01495 0.11018 131.751 0.91243 0.94278
tetM, tetO; ribosomal protection tetracycline resistance protein 0.72785 0.17690 0.56923 1.32326 0.14268 65 0.83871 7.48729 0.28374 93 0.31759 -0.84850 132.254 0.39769 0.59014
eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] 0.72622 0.19784 0.47956 2.04833 0.17752 65 0.89862 9.05571 0.31205 93 0.35901 -1.16727 140.092 0.24509 0.59014
xylS, yicI; alpha-D-xyloside xylohydrolase [EC:3.2.1.177] 0.72369 0.19004 0.48659 2.04561 0.17740 65 0.88940 8.24762 0.29780 93 0.34663 -1.16205 142.995 0.24715 0.59014
K06975; uncharacterized protein 0.72038 0.14227 0.54800 1.50188 0.15201 65 0.84086 4.37679 0.21694 93 0.26489 -1.10558 151.885 0.27066 0.59014
fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] 0.69316 0.16032 0.42108 0.64380 0.09952 65 0.88333 6.39306 0.26219 93 0.28044 -1.64832 116.932 0.10197 0.59014
ihfA, himA; integration host factor subunit alpha 0.68861 0.17835 0.54735 2.94573 0.21288 65 0.78734 6.50313 0.26444 93 0.33948 -0.70693 155.814 0.48067 0.59915
K06926; uncharacterized protein 0.68662 0.11928 0.49315 0.87604 0.11609 65 0.82185 3.18210 0.18498 93 0.21839 -1.50512 146.154 0.13445 0.59014
E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6] 0.68553 0.18938 0.47956 2.04833 0.17752 65 0.82949 8.19488 0.29685 93 0.34588 -1.01173 143.235 0.31337 0.59014
E2.2.1.6S, ilvH, ilvN; acetolactate synthase I/III small subunit [EC:2.2.1.6] 0.68553 0.18938 0.47956 2.04833 0.17752 65 0.82949 8.19488 0.29685 93 0.34588 -1.01173 143.235 0.31337 0.59014
idnO; gluconate 5-dehydrogenase [EC:1.1.1.69] 0.68553 0.18951 0.48176 2.07329 0.17860 65 0.82796 8.19102 0.29678 93 0.34637 -0.99951 143.624 0.31923 0.59014
ilvC; ketol-acid reductoisomerase [EC:1.1.1.86] 0.68553 0.18938 0.47956 2.04833 0.17752 65 0.82949 8.19488 0.29685 93 0.34588 -1.01173 143.235 0.31337 0.59014
ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9] 0.68553 0.18938 0.47956 2.04833 0.17752 65 0.82949 8.19488 0.29685 93 0.34588 -1.01173 143.235 0.31337 0.59014
tolA; colicin import membrane protein 0.68375 0.10467 0.61902 1.18828 0.13521 65 0.72898 2.12244 0.15107 93 0.20274 -0.54238 155.236 0.58833 0.67888
E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46] 0.68291 0.16114 0.44462 0.89958 0.11764 65 0.84946 6.30692 0.26042 93 0.28576 -1.41676 125.847 0.15902 0.59014
queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50] 0.68241 0.14779 0.53108 1.53653 0.15375 65 0.78817 4.79279 0.22701 93 0.27418 -0.93769 150.299 0.34991 0.59014
wcaJ; putative colanic acid biosysnthesis UDP-glucose lipid carrier transferase 0.67608 0.17518 0.51415 1.52777 0.15331 65 0.78925 7.17988 0.27785 93 0.31734 -0.86686 138.140 0.38752 0.59014
glf; UDP-galactopyranose mutase [EC:5.4.99.9] 0.66237 0.13315 0.53594 1.44317 0.14901 65 0.75073 3.75708 0.20099 93 0.25020 -0.85846 154.033 0.39197 0.59014
vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-] 0.65759 0.15451 0.54615 1.78909 0.16590 65 0.73548 5.17710 0.23594 93 0.28843 -0.65641 152.038 0.51255 0.61634
htpX; heat shock protein HtpX [EC:3.4.24.-] 0.65535 0.13230 0.49231 1.24481 0.13839 65 0.76931 3.82152 0.20271 93 0.24544 -1.12856 150.687 0.26088 0.59014
ABC.CD.TX; HlyD family secretion protein 0.65479 0.16521 0.45209 3.06882 0.21728 65 0.79647 5.17557 0.23591 93 0.32072 -1.07375 154.484 0.28461 0.59014
K09797; uncharacterized protein 0.65190 0.13030 0.50549 1.93388 0.17249 65 0.75422 3.20657 0.18569 93 0.25344 -0.98142 154.213 0.32792 0.59014
cas1; CRISP-associated protein Cas1 0.64887 0.13600 0.44103 1.01234 0.12480 65 0.79413 4.23077 0.21329 93 0.24712 -1.42890 141.873 0.15523 0.59014
cas2; CRISPR-associated protein Cas2 0.64887 0.13600 0.44103 1.01234 0.12480 65 0.79413 4.23077 0.21329 93 0.24712 -1.42890 141.873 0.15523 0.59014
ABC.X2.P; putative ABC transport system permease protein 0.64747 0.13376 0.46154 0.93772 0.12011 65 0.77742 4.13068 0.21075 93 0.24257 -1.30220 140.207 0.19498 0.59014
E3.2.1.89; arabinogalactan endo-1,4-beta-galactosidase [EC:3.2.1.89] 0.63648 0.16168 0.46601 1.35653 0.14446 65 0.75562 6.06953 0.25547 93 0.29349 -0.98679 139.710 0.32545 0.59014
apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12] 0.63386 0.16633 0.42538 1.56647 0.15524 65 0.77957 6.31739 0.26063 93 0.30336 -1.16753 142.987 0.24494 0.59014
TC.GPH; glycoside/pentoside/hexuronide:cation symporter, GPH family 0.63386 0.16633 0.42538 1.56647 0.15524 65 0.77957 6.31739 0.26063 93 0.30336 -1.16753 142.987 0.24494 0.59014
thrC; threonine synthase [EC:4.2.3.1] 0.63386 0.16633 0.42538 1.56647 0.15524 65 0.77957 6.31739 0.26063 93 0.30336 -1.16753 142.987 0.24494 0.59014
abnA; arabinan endo-1,5-alpha-L-arabinosidase [EC:3.2.1.99] 0.62841 0.14992 0.43179 1.32576 0.14282 65 0.76583 5.09164 0.23398 93 0.27413 -1.21855 144.489 0.22500 0.59014
amn; AMP nucleosidase [EC:3.2.2.4] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
coaX; type III pantothenate kinase [EC:2.7.1.33] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
cysC; adenylylsulfate kinase [EC:2.7.1.25] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
cysN; sulfate adenylyltransferase subunit 1 [EC:2.7.7.4] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
cysQ, MET22, BPNT1; 3’(2’), 5’-bisphosphate nucleotidase [EC:3.1.3.7] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
E3.1.11.5; exodeoxyribonuclease V [EC:3.1.11.5] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
EIF1, SUI1; translation initiation factor 1 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
K06973; uncharacterized protein 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
K07043; uncharacterized protein 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
K07150; uncharacterized protein 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
marC; multiple antibiotic resistance protein 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
mbtN, fadE14; acyl-ACP dehydrogenase [EC:1.3.99.-] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
mepS, spr; murein DD-endopeptidase / murein LD-carboxypeptidase [EC:3.4.-.- 3.4.17.13] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
mscS; small conductance mechanosensitive channel 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
pcnB; poly(A) polymerase [EC:2.7.7.19] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
pdxB; erythronate-4-phosphate dehydrogenase [EC:1.1.1.290] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
pdxJ; pyridoxine 5-phosphate synthase [EC:2.6.99.2] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
tpx; thiol peroxidase, atypical 2-Cys peroxiredoxin [EC:1.11.1.15] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
ybaK, ebsC; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-] 0.61392 0.30670 0.36923 6.20529 0.30898 65 0.78495 20.97499 0.47491 93 0.56657 -0.73374 148.198 0.46427 0.59014
purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] 0.59863 0.14194 0.47692 2.30979 0.18851 65 0.68369 3.80745 0.20234 93 0.27654 -0.74769 154.115 0.45578 0.59014
cobC, phpB; alpha-ribazole phosphatase [EC:3.1.3.73] 0.59351 0.15114 0.37731 0.75533 0.10780 65 0.74462 5.57742 0.24489 93 0.26757 -1.37279 124.393 0.17229 0.59014
cobP, cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62] 0.59351 0.15114 0.37731 0.75533 0.10780 65 0.74462 5.57742 0.24489 93 0.26757 -1.37279 124.393 0.17229 0.59014
E2.4.2.21, cobU, cobT; nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21] 0.59351 0.15114 0.37731 0.75533 0.10780 65 0.74462 5.57742 0.24489 93 0.26757 -1.37279 124.393 0.17229 0.59014
E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26] 0.59351 0.15114 0.37731 0.75533 0.10780 65 0.74462 5.57742 0.24489 93 0.26757 -1.37279 124.393 0.17229 0.59014
znuB; zinc transport system permease protein 0.59017 0.11499 0.44166 0.93124 0.11969 65 0.69396 2.89104 0.17631 93 0.21310 -1.18395 150.415 0.23830 0.59014
znuC; zinc transport system ATP-binding protein [EC:3.6.3.-] 0.59017 0.11499 0.44166 0.93124 0.11969 65 0.69396 2.89104 0.17631 93 0.21310 -1.18395 150.415 0.23830 0.59014
SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1] 0.58763 0.11111 0.45680 0.92527 0.11931 65 0.67907 2.66422 0.16926 93 0.20708 -1.07334 152.144 0.28482 0.59014
ABC.CD.A; putative ABC transport system ATP-binding protein 0.58685 0.13839 0.39101 1.52189 0.15302 65 0.72374 4.05946 0.20893 93 0.25897 -1.28485 153.627 0.20078 0.59014
nosD; nitrous oxidase accessory protein 0.58228 0.27015 0.47692 9.34712 0.37921 65 0.65591 13.16293 0.37621 93 0.53417 -0.33508 150.536 0.73803 0.79501
nosF; Cu-processing system ATP-binding protein 0.58228 0.27015 0.47692 9.34712 0.37921 65 0.65591 13.16293 0.37621 93 0.53417 -0.33508 150.536 0.73803 0.79501
nosY; Cu-processing system permease protein 0.58228 0.27015 0.47692 9.34712 0.37921 65 0.65591 13.16293 0.37621 93 0.53417 -0.33508 150.536 0.73803 0.79501
nosZ; nitrous-oxide reductase [EC:1.7.2.4] 0.58228 0.27015 0.47692 9.34712 0.37921 65 0.65591 13.16293 0.37621 93 0.53417 -0.33508 150.536 0.73803 0.79501
ramA; alpha-L-rhamnosidase [EC:3.2.1.40] 0.58228 0.27015 0.47692 9.34712 0.37921 65 0.65591 13.16293 0.37621 93 0.53417 -0.33508 150.536 0.73803 0.79501
rnj; ribonuclease J [EC:3.1.-.-] 0.58228 0.27015 0.47692 9.34712 0.37921 65 0.65591 13.16293 0.37621 93 0.53417 -0.33508 150.536 0.73803 0.79501
spsF; spore coat polysaccharide biosynthesis protein SpsF 0.58228 0.27015 0.47692 9.34712 0.37921 65 0.65591 13.16293 0.37621 93 0.53417 -0.33508 150.536 0.73803 0.79501
tolC; outer membrane protein 0.58146 0.13394 0.39473 1.74187 0.16370 65 0.71198 3.58390 0.19631 93 0.25561 -1.24119 156.000 0.21640 0.59014
mltF; membrane-bound lytic murein transglycosylase F [EC:4.2.2.-] 0.56293 0.10702 0.41670 0.80029 0.11096 65 0.66513 2.50577 0.16415 93 0.19813 -1.25385 150.205 0.21184 0.59014
K09117; uncharacterized protein 0.56144 0.11437 0.41207 0.89689 0.11747 65 0.66584 2.87606 0.17586 93 0.21148 -1.19997 149.601 0.23205 0.59014
pheA2; prephenate dehydratase [EC:4.2.1.51] 0.54437 0.11659 0.35530 0.54727 0.09176 65 0.67652 3.24171 0.18670 93 0.20803 -1.54412 130.839 0.12497 0.59014
yoeB; toxin YoeB [EC:3.1.-.-] 0.53376 0.12571 0.56923 1.97473 0.17430 65 0.50896 2.88549 0.17614 93 0.24780 0.24322 151.530 0.80817 0.85466
eamB; cysteine/O-acetylserine efflux protein 0.52532 0.36271 0.55385 16.84471 0.50907 65 0.50538 23.75269 0.50538 93 0.71732 0.06757 150.573 0.94622 0.95197
K09124; uncharacterized protein 0.52532 0.36271 0.55385 16.84471 0.50907 65 0.50538 23.75269 0.50538 93 0.71732 0.06757 150.573 0.94622 0.95197
tagF; CDP-glycerol glycerophosphotransferase [EC:2.7.8.12] 0.52532 0.36271 0.55385 16.84471 0.50907 65 0.50538 23.75269 0.50538 93 0.71732 0.06757 150.573 0.94622 0.95197
pgpA; phosphatidylglycerophosphatase A [EC:3.1.3.27] 0.52363 0.14626 0.51897 1.94007 0.17276 65 0.52688 4.41865 0.21797 93 0.27814 -0.02843 155.616 0.97736 0.97905
E3.2.1.17; lysozyme [EC:3.2.1.17] 0.51899 0.11395 0.53077 1.59279 0.15654 65 0.51075 2.39255 0.16039 93 0.22412 0.08931 152.213 0.92895 0.94278
aat; leucyl/phenylalanyl-tRNA—protein transferase [EC:2.3.2.6] 0.51730 0.12525 0.53436 1.92882 0.17226 65 0.50538 2.88795 0.17622 93 0.24643 0.11761 152.136 0.90653 0.94278
clpA; ATP-dependent Clp protease ATP-binding subunit ClpA 0.51730 0.12525 0.53436 1.92882 0.17226 65 0.50538 2.88795 0.17622 93 0.24643 0.11761 152.136 0.90653 0.94278
clpS; ATP-dependent Clp protease adaptor protein ClpS 0.51730 0.12525 0.53436 1.92882 0.17226 65 0.50538 2.88795 0.17622 93 0.24643 0.11761 152.136 0.90653 0.94278
yafQ; mRNA interferase YafQ [EC:3.1.-.-] 0.50497 0.16244 0.30769 0.63567 0.09889 65 0.64286 6.62555 0.26691 93 0.28464 -1.17749 115.853 0.24141 0.59014
K09805; uncharacterized protein 0.48133 0.12772 0.31077 0.64144 0.09934 65 0.60054 3.91698 0.20523 93 0.22801 -1.27088 129.910 0.20604 0.59014
murQ; N-acetylmuramic acid 6-phosphate etherase [EC:4.2.1.126] 0.47710 0.11628 0.28839 0.40133 0.07858 65 0.60899 3.32371 0.18905 93 0.20473 -1.56599 121.329 0.11995 0.59014
xylA; xylose isomerase [EC:5.3.1.5] 0.47152 0.26006 0.44615 10.50096 0.40194 65 0.48925 10.92923 0.34281 93 0.52827 -0.08157 139.592 0.93510 0.94558
uxaC; glucuronate isomerase [EC:5.3.1.12] 0.46722 0.12602 0.26338 0.40408 0.07885 65 0.60968 3.95088 0.20611 93 0.22068 -1.56921 117.285 0.11929 0.59014
pgsA, PGS1; CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5] 0.46076 0.11582 0.40077 1.08496 0.12920 65 0.50269 2.85801 0.17530 93 0.21777 -0.46802 153.840 0.64044 0.72354
czcA; cobalt-zinc-cadmium resistance protein CzcA 0.46034 0.11758 0.59077 2.19943 0.18395 65 0.36918 2.17745 0.15301 93 0.23927 0.92612 137.435 0.35601 0.59014
padR; PadR family transcriptional regulator, regulatory protein PadR 0.45253 0.20371 0.18462 1.55132 0.15449 65 0.63978 10.02373 0.32830 93 0.36283 -1.25448 128.217 0.21195 0.59014
csn1, cas9; CRISPR-associated endonuclease Csn1 [EC:3.1.-.-] 0.44321 0.09509 0.32991 0.94998 0.12089 65 0.52240 1.76175 0.13764 93 0.18319 -1.05075 155.590 0.29500 0.59014
bgaB, lacA; beta-galactosidase [EC:3.2.1.23] 0.44143 0.09679 0.28249 0.30667 0.06869 65 0.55252 2.28238 0.15666 93 0.17105 -1.57866 124.176 0.11696 0.59014
agaR; DeoR family transcriptional regulator, aga operon transcriptional repressor 0.42722 0.15725 0.26154 2.38365 0.19150 65 0.54301 4.97639 0.23132 93 0.30030 -0.93730 155.992 0.35005 0.59014
pepE; dipeptidase E [EC:3.4.13.21] 0.41845 0.10157 0.27811 0.46453 0.08454 65 0.51654 2.43470 0.16180 93 0.18255 -1.30611 134.660 0.19374 0.59014
rhaM; L-rhamnose mutarotase [EC:5.1.3.32] 0.41139 0.17535 0.23077 1.67248 0.16041 65 0.53763 7.08824 0.27608 93 0.31929 -0.96108 141.431 0.33815 0.59014
PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] 0.39873 0.09404 0.40769 1.08314 0.12909 65 0.39247 1.63098 0.13243 93 0.18494 0.08229 152.271 0.93452 0.94558
troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator 0.39873 0.09404 0.40769 1.08314 0.12909 65 0.39247 1.63098 0.13243 93 0.18494 0.08229 152.271 0.93452 0.94558
pnbA; para-nitrobenzyl esterase [EC:3.1.1.-] 0.39557 0.15968 0.28462 2.45288 0.19426 65 0.47312 5.15416 0.23542 93 0.30522 -0.61760 155.983 0.53774 0.63858
dinD; DNA-damage-inducible protein D 0.37046 0.11444 0.32872 1.31388 0.14217 65 0.39964 2.61542 0.16770 93 0.21986 -0.32259 155.959 0.74744 0.80237
E2.4.1.20; cellobiose phosphorylase [EC:2.4.1.20] 0.36772 0.24592 0.40154 10.39890 0.39998 65 0.34409 9.07054 0.31230 93 0.50746 0.11322 131.756 0.91003 0.94278
xylE; MFS transporter, SP family, xylose:H+ symportor 0.36772 0.24592 0.40154 10.39890 0.39998 65 0.34409 9.07054 0.31230 93 0.50746 0.11322 131.756 0.91003 0.94278
dapF; diaminopimelate epimerase [EC:5.1.1.7] 0.35994 0.06710 0.28031 0.45305 0.08349 65 0.41559 0.89130 0.09790 93 0.12866 -1.05147 155.925 0.29467 0.59014
E2.6.1.83; LL-diaminopimelate aminotransferase [EC:2.6.1.83] 0.35994 0.06710 0.28031 0.45305 0.08349 65 0.41559 0.89130 0.09790 93 0.12866 -1.05147 155.925 0.29467 0.59014
znuA; zinc transport system substrate-binding protein 0.35732 0.07854 0.28615 0.45511 0.08368 65 0.40707 1.34070 0.12007 93 0.14635 -0.82619 151.646 0.40999 0.59014
zraR, hydG; two-component system, NtrC family, response regulator HydG 0.33228 0.15465 0.23846 1.71959 0.16265 65 0.39785 5.24217 0.23742 93 0.28779 -0.55384 150.855 0.58051 0.67493
K06921; uncharacterized protein 0.32743 0.10964 0.22154 1.32262 0.14265 65 0.40143 2.30751 0.15752 93 0.21251 -0.84653 154.959 0.39856 0.59014
trpA; tryptophan synthase alpha chain [EC:4.2.1.20] 0.31477 0.17337 0.29846 4.66654 0.26794 65 0.32616 4.85744 0.22854 93 0.35217 -0.07866 139.597 0.93741 0.94558
trpD; anthranilate phosphoribosyltransferase [EC:2.4.2.18] 0.31477 0.17337 0.29846 4.66654 0.26794 65 0.32616 4.85744 0.22854 93 0.35217 -0.07866 139.597 0.93741 0.94558
trpE; anthranilate synthase component I [EC:4.1.3.27] 0.31477 0.17337 0.29846 4.66654 0.26794 65 0.32616 4.85744 0.22854 93 0.35217 -0.07866 139.597 0.93741 0.94558
lplA, lplJ; lipoate—protein ligase [EC:6.3.1.20] 0.30922 0.09671 0.19121 0.96829 0.12205 65 0.39171 1.83137 0.14033 93 0.18598 -1.07805 155.732 0.28268 0.59014
bdhAB; butanol dehydrogenase [EC:1.1.1.-] 0.30759 0.15335 0.18615 1.55090 0.15447 65 0.39247 5.24375 0.23745 93 0.28327 -0.72834 148.191 0.46756 0.59173
sbcD, mre11; DNA repair protein SbcD/Mre11 0.30759 0.15335 0.18615 1.55090 0.15447 65 0.39247 5.24375 0.23745 93 0.28327 -0.72834 148.191 0.46756 0.59173
TC.SULP; sulfate permease, SulP family 0.30759 0.15335 0.18615 1.55090 0.15447 65 0.39247 5.24375 0.23745 93 0.28327 -0.72834 148.191 0.46756 0.59173
K07014; uncharacterized protein 0.29430 0.13507 0.23846 2.33678 0.18961 65 0.33333 3.28986 0.18808 93 0.26707 -0.35523 150.528 0.72291 0.78678
dnaC; DNA replication protein DnaC 0.29114 0.27240 0.00000 0.00000 0.00000 65 0.49462 19.90486 0.46263 93 0.46263 -1.06915 92.000 0.28780 0.59014
K06915; uncharacterized protein 0.29114 0.27240 0.00000 0.00000 0.00000 65 0.49462 19.90486 0.46263 93 0.46263 -1.06915 92.000 0.28780 0.59014
K07078; uncharacterized protein 0.29114 0.27240 0.00000 0.00000 0.00000 65 0.49462 19.90486 0.46263 93 0.46263 -1.06915 92.000 0.28780 0.59014
utp; urea transporter 0.29114 0.27240 0.00000 0.00000 0.00000 65 0.49462 19.90486 0.46263 93 0.46263 -1.06915 92.000 0.28780 0.59014
K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72] 0.28797 0.18249 0.33077 4.36935 0.25927 65 0.25806 5.93811 0.25269 93 0.36204 0.20082 149.496 0.84111 0.88546
fecA; Fe(3+) dicitrate transport protein 0.28727 0.05021 0.25385 0.24190 0.06100 65 0.31063 0.51015 0.07406 93 0.09595 -0.59182 155.976 0.55483 0.65055
K07090; uncharacterized protein 0.27255 0.05523 0.22500 0.40415 0.07885 65 0.30578 0.53851 0.07609 93 0.10958 -0.73716 148.884 0.46218 0.59014
bshA; L-malate glycosyltransferase [EC:2.4.1.-] 0.27215 0.16573 0.04615 0.04471 0.02623 65 0.43011 7.31300 0.28042 93 0.28164 -1.36327 93.606 0.17607 0.59014
csxA; exo-1,4-beta-D-glucosaminidase [EC:3.2.1.165] 0.27215 0.16573 0.04615 0.04471 0.02623 65 0.43011 7.31300 0.28042 93 0.28164 -1.36327 93.606 0.17607 0.59014
E2.5.1.56, neuB; N-acetylneuraminate synthase [EC:2.5.1.56] 0.27215 0.16573 0.04615 0.04471 0.02623 65 0.43011 7.31300 0.28042 93 0.28164 -1.36327 93.606 0.17607 0.59014
E3.5.2.10; creatinine amidohydrolase [EC:3.5.2.10] 0.27215 0.16573 0.04615 0.04471 0.02623 65 0.43011 7.31300 0.28042 93 0.28164 -1.36327 93.606 0.17607 0.59014
FLOT; flotillin 0.27215 0.16573 0.04615 0.04471 0.02623 65 0.43011 7.31300 0.28042 93 0.28164 -1.36327 93.606 0.17607 0.59014
higB-1; toxin HigB-1 0.27215 0.16573 0.04615 0.04471 0.02623 65 0.43011 7.31300 0.28042 93 0.28164 -1.36327 93.606 0.17607 0.59014
K13652; AraC family transcriptional regulator 0.27215 0.16573 0.04615 0.04471 0.02623 65 0.43011 7.31300 0.28042 93 0.28164 -1.36327 93.606 0.17607 0.59014
neuA; N-acylneuraminate cytidylyltransferase [EC:2.7.7.43] 0.27215 0.16573 0.04615 0.04471 0.02623 65 0.43011 7.31300 0.28042 93 0.28164 -1.36327 93.606 0.17607 0.59014
RTCB, rtcB; tRNA-splicing ligase RtcB (3’-phosphate/5’-hydroxy nucleic acid ligase) [EC:6.5.1.8] 0.27215 0.16573 0.04615 0.04471 0.02623 65 0.43011 7.31300 0.28042 93 0.28164 -1.36327 93.606 0.17607 0.59014
TC.CPA1; monovalent cation:H+ antiporter, CPA1 family 0.27215 0.16573 0.04615 0.04471 0.02623 65 0.43011 7.31300 0.28042 93 0.28164 -1.36327 93.606 0.17607 0.59014
INV, sacA; beta-fructofuranosidase [EC:3.2.1.26] 0.26846 0.05911 0.19487 0.46751 0.08481 65 0.31989 0.61040 0.08102 93 0.11729 -1.06595 148.231 0.28818 0.59014
dexA; dextranase [EC:3.2.1.11] 0.26772 0.06391 0.22462 0.67001 0.10153 65 0.29785 0.63304 0.08250 93 0.13082 -0.55979 135.370 0.57654 0.67167
tatA; sec-independent protein translocase protein TatA 0.26582 0.10644 0.18974 1.09017 0.12951 65 0.31900 2.28965 0.15691 93 0.20345 -0.63531 155.984 0.52616 0.62749
tatC; sec-independent protein translocase protein TatC 0.26582 0.10644 0.18974 1.09017 0.12951 65 0.31900 2.28965 0.15691 93 0.20345 -0.63531 155.984 0.52616 0.62749
ltaE; threonine aldolase [EC:4.1.2.48] 0.26498 0.09697 0.23897 1.40165 0.14685 65 0.28315 1.55965 0.12950 93 0.19579 -0.22565 142.358 0.82180 0.86592
ABC.X2.A; putative ABC transport system ATP-binding protein 0.24051 0.11969 0.06923 0.14748 0.04763 65 0.36022 3.72481 0.20013 93 0.20572 -1.41447 102.247 0.16026 0.59014
argB; acetylglutamate kinase [EC:2.7.2.8] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
argE; acetylornithine deacetylase [EC:3.5.1.16] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
argF; N-succinyl-L-ornithine transcarbamylase [EC:2.1.3.11] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
argG, ASS1; argininosuccinate synthase [EC:6.3.4.5] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
argH, ASL; argininosuccinate lyase [EC:4.3.2.1] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
cimA; (R)-citramalate synthase [EC:2.3.1.182] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
E2.6.1.11, argD; acetylornithine aminotransferase [EC:2.6.1.11] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
hisB; imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase [EC:4.2.1.19 3.1.3.15] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
hisD; histidinol dehydrogenase [EC:1.1.1.23] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
hisF; cyclase [EC:4.1.3.-] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
hisG; ATP phosphoribosyltransferase [EC:2.4.2.17] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
hisH; glutamine amidotransferase [EC:2.4.2.-] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
hisIE; phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase [EC:3.6.1.31 3.5.4.19] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
leuB, IMDH; 3-isopropylmalate dehydrogenase [EC:1.1.1.85] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
leuC, IPMI-L; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
leuD, IPMI-S; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35] 0.23766 0.13002 0.22385 2.62493 0.20096 65 0.24731 2.73165 0.17138 93 0.26411 -0.08885 139.587 0.92933 0.94278
GLO1, gloA; lactoylglutathione lyase [EC:4.4.1.5] 0.23259 0.08954 0.11154 0.39069 0.07753 65 0.31720 1.87247 0.14189 93 0.16169 -1.27195 137.511 0.20554 0.59014
cvrA, nhaP2; cell volume regulation protein A 0.20886 0.17482 0.09231 0.55385 0.09231 65 0.29032 7.83871 0.29032 93 0.30464 -0.64999 109.926 0.51706 0.62047
proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2] 0.19968 0.12364 0.21615 2.60298 0.20011 65 0.18817 2.31067 0.15763 93 0.25474 0.10985 132.556 0.91270 0.94278
umuD; DNA polymerase V [EC:3.4.21.-] 0.18819 0.10575 0.01641 0.00500 0.00877 65 0.30824 2.97642 0.17890 93 0.17911 -1.62933 92.442 0.10665 0.59014
hipO; hippurate hydrolase [EC:3.5.1.32] 0.17089 0.13785 0.05385 0.18846 0.05385 65 0.25269 4.97622 0.23132 93 0.23750 -0.83722 101.811 0.40443 0.59014
K07496; putative transposase 0.15190 0.13414 0.32308 6.78462 0.32308 65 0.03226 0.09677 0.03226 93 0.32468 0.89570 65.278 0.37370 0.59014
res; type III restriction enzyme [EC:3.1.21.5] 0.14620 0.13620 0.00154 0.00015 0.00154 65 0.24731 4.97622 0.23132 93 0.23132 -1.06247 92.008 0.29080 0.59014
ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:3.6.3.21] 0.13671 0.08286 0.02462 0.01126 0.01316 65 0.21505 1.82825 0.14021 93 0.14083 -1.35230 93.618 0.17954 0.59014
ACO, acnA; aconitate hydratase [EC:4.2.1.3] 0.06677 0.04503 0.05077 0.08043 0.03518 65 0.07796 0.49046 0.07262 93 0.08069 -0.33693 129.952 0.73671 0.79501
IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42] 0.06677 0.04503 0.05077 0.08043 0.03518 65 0.07796 0.49046 0.07262 93 0.08069 -0.33693 129.952 0.73671 0.79501
citD; citrate lyase subunit gamma (acyl carrier protein) 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34] 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10] 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
citX; holo-ACP synthase [EC:2.7.7.61] 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
dndC; DNA sulfur modification protein DndC 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
dndE; DNA sulfur modification protein DndE 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
elaA; ElaA protein 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
K02481; two-component system, NtrC family, response regulator 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
K07220; uncharacterized protein 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
K07491; putative transposase 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
kdpA; K+-transporting ATPase ATPase A chain [EC:3.6.3.12] 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
kdpB; K+-transporting ATPase ATPase B chain [EC:3.6.3.12] 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
kdpC; K+-transporting ATPase ATPase C chain [EC:3.6.3.12] 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
ltrA; RNA-directed DNA polymerase [EC:2.7.7.49] 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
norB, norC; MFS transporter, DHA2 family, multidrug resistance protein 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
raxB, cvaB; ATP-binding cassette, subfamily B, bacterial RaxB 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
ribB, RIB3; 3,4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12] 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
TC.PIT; inorganic phosphate transporter, PiT family 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
wcaK, amsJ; colanic acid/amylovoran biosynthesis protein 0.05063 0.04471 0.10769 0.75385 0.10769 65 0.01075 0.01075 0.01075 93 0.10823 0.89570 65.278 0.37370 0.59014
dndD; DNA sulfur modification protein DndD 0.02595 0.02236 0.05538 0.18845 0.05384 65 0.00538 0.00269 0.00538 93 0.05411 0.92417 65.278 0.35880 0.59014
amt, AMT, MEP; ammonium transporter, Amt family 0.00253 0.00253 0.00615 0.00246 0.00615 65 0.00000 0.00000 0.00000 93 0.00615 1.00000 64.000 0.32108 0.59014
ABC.PA.S; polar amino acid transport system substrate-binding protein 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
asnB, ASNS; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4] 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
CS, gltA; citrate synthase [EC:2.3.3.1] 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
cysH; phosphoadenosine phosphosulfate reductase [EC:1.8.4.8 1.8.4.10] 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
czcB; membrane fusion protein, cobalt-zinc-cadmium efflux system 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
DNPEP; aspartyl aminopeptidase [EC:3.4.11.21] 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
E3.2.1.4; endoglucanase [EC:3.2.1.4] 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
E3.2.1.8, xynA; endo-1,4-beta-xylanase [EC:3.2.1.8] 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
emrA; membrane fusion protein, multidrug efflux system 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
glnB; nitrogen regulatory protein P-II 1 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
gltB; glutamate synthase (NADPH/NADH) large chain [EC:1.4.1.13 1.4.1.14] 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
gmhA, lpcA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28] 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83] 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
hddA; D-glycero-alpha-D-manno-heptose-7-phosphate kinase [EC:2.7.1.168] 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
K07166; ACT domain-containing protein 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
K07484; transposase 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
K09157; uncharacterized protein 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
K09922; uncharacterized protein 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
modF; molybdate transport system ATP-binding protein 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
nhaC; Na+:H+ antiporter, NhaC family 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
pip; proline iminopeptidase [EC:3.4.11.5] 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41] 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
proB; glutamate 5-kinase [EC:2.7.2.11] 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
rnfA; electron transport complex protein RnfA 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
rnfC; electron transport complex protein RnfC 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
rnfD; electron transport complex protein RnfD 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
rnfE; electron transport complex protein RnfE 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
rseC; sigma-E factor negative regulatory protein RseC 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
thiG; thiazole synthase [EC:2.8.1.10] 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
thiH; 2-iminoacetate synthase [EC:4.1.99.19] 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
thiS; sulfur carrier protein 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014
yaeR; glyoxylase I family protein 0.00127 0.00127 0.00308 0.00062 0.00308 65 0.00000 0.00000 0.00000 93 0.00308 1.00000 64.000 0.32108 0.59014 
plot.dat <- tb.ra %>%
  arrange(p) %>%
  slice_head(n=50)%>%
  mutate(
    description = fct_reorder(description, `Overall Mean`),
    description = factor(description, levels = levels(description), ordered=T)
  ) %>%
  arrange(description) %>%
  mutate(
    id = 1:n(),
    step = ifelse(id%%2 == 0, 1, 0),
    Mean_diff = `Tumor Mean` - `Non-Tumor Mean`,
    diff_se = SEpooled,
    Mean_diff_ll = Mean_diff - qt(0.975, df)*diff_se,
    Mean_diff_ul = Mean_diff + qt(0.975, df)*diff_se
  ) %>%
  pivot_longer(
    cols=contains("Mean"),
    names_to = "group",
    values_to = "mean"
  )



p1.d <- plot.dat %>%
  filter(group %in% c("Tumor Mean","Non-Tumor Mean")) %>%
  mutate(
    group = ifelse(group == "Tumor Mean", "Tumor", "Non-Tumor"),
    col = ifelse(step == 1, "grey90", "white"),
    h=1, w=Inf
    
  )
p1 <- ggplot()+
  geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_bar(data=p1.d,
             aes(x=mean, y=description,
                 group=group, color=group,
                 fill=group),
             stat="identity",position = "dodge",
             alpha = 1)+
    labs(x="Mean Abundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      plot.margin = unit(c(1,0,1,1), "lines")
    )

p2.d <- plot.dat %>%
  filter(group %in% c("Mean_diff", "Mean_diff_ll", "Mean_diff_ul")) %>%
  pivot_wider(
    names_from = group,
    values_from = mean
  ) %>%
  mutate(
    group = ifelse(Mean_diff > 0, "Tumor", "Non-Tumor"),
    p = sprintf("%.3f", round(p,3)),
    ll = min(Mean_diff_ll)-0.01,
    ul = max(Mean_diff_ul)+0.01
  )
p2<-ggplot(p2.d, aes(x=Mean_diff, y=description))+
    geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_vline(xintercept = 0, linetype="dashed", alpha=0.5)+
    geom_segment(aes(x=Mean_diff_ll, y=description, xend=Mean_diff_ul, yend=description))+
    geom_point(aes(fill=group, color=group))+
    geom_text(aes(label=p, x=unique(ul)+0.1))+
    coord_cartesian(xlim = c(unique(p2.d$ll), unique(p2.d$ul)),
                    clip = 'off') +
    annotate("text", x=unique(p2.d$ul)+0.2,y = 25,
             angle=90,
             label="p-value (uncorrected)")+
    labs(x="Mean Difference in Abundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      axis.title.y = element_blank(),
      axis.text.y = element_blank(),
      axis.line.y = element_blank(),
      axis.ticks.y = element_blank(),
      plot.margin = unit(c(1,4,1,0), "lines")
    )

# plot
p1 + p2 +
  plot_annotation(title="Stratefied KO Data - Prevotella spp. (genus level only): First 50 descriptions with lowest p-value (uncorrected)")

Modeling Difference between Tumor and Non-Tumor

For the modeling, we used a generalized linear mixed model (GLMM).

First, we looked at the biserial correlation between the abundance of each description and the tumor status.

tb <- mydata %>%
  group_by(description)%>%
  summarise(
    r = cor(tumor, Abundance)
  ) %>%
  mutate(
    M=mean(r)
  )

ggplot(tb, aes(x=r))+
  geom_density()+
  geom_vline(aes(xintercept = M))+
  labs(x="Biserial Correlation",title="Relationship between description abundance and tumor (tumor vs. non-tumor)")+
  theme(panel.grid = element_blank())

Next, we need the data to be on an interpretable scale. First, let’s use the raw abundance like scale.

p <- ggplot(mydata, aes(x=Abundance))+
  geom_density()
p

mydata <- mydata %>%
  mutate(Abundance.dich=ifelse(Abundance==0, 0, 1))
table(mydata$Abundance.dich)

     0      1 
 80642 102322

Let’s first run models by description so that we can avoid the nesting issue initially. We will come back to this to conduct the final model (it will be more powerful).

DESCRIPTIONS <- unique(mydata$description)
i<-1
dat0 <- mydata %>% filter(description==DESCRIPTIONS[i])

# quasipossion (approximately negative binom) give an approx. answer.
fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
summary(fit0)

Call:
glm(formula = Abundance ~ 1 + tumor, family = quasipoisson(link = "log"), 
    data = dat0)

Deviance Residuals: 
   Min      1Q  Median      3Q     Max  
-1.392  -1.241  -0.906   0.232   5.513  

Coefficients:
            Estimate Std. Error t value Pr(>|t|)
(Intercept)  -0.0311     0.1770   -0.18     0.86
tumor        -0.2305     0.2963   -0.78     0.44

(Dispersion parameter for quasipoisson family taken to be 2.8254)

    Null deviance: 293.35  on 157  degrees of freedom
Residual deviance: 291.61  on 156  degrees of freedom
AIC: NA

Number of Fisher Scoring iterations: 6

NExt, let’s model the percent relative abundance. This will allow us to make inference about the difference average relative abundance. Which is a simpler interpretation than trying to model differences in the log relative abundance which will need to be interpreted as the multiplicative relative change.

results.out <- as.data.frame(matrix(ncol=4, nrow=length(DESCRIPTIONS)))
colnames(results.out) <- c("description", "Est", "SE", "p")
#results.out$description <-DESCRIPTIONS

i <- 1
for(i in 1:length(DESCRIPTIONS)){
#for(i in 1:5){ 
  dat0 <- mydata %>%
    filter(description == DESCRIPTIONS[i])
  fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
  fit.sum <- summary(fit0)
  results.out[i, 1] <- DESCRIPTIONS[i]
  results.out[i, 2:4] <- fit.sum$coefficients[2, c(1,2,4)]
}

results.out$fdr_p <- p.adjust(results.out$p, method="fdr")

kable(results.out, format="html", digits=3) %>%
  kable_styling(full_width = T)%>%
  scroll_box(width="100%", height="600px")
description Est SE p fdr_p
AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7] -0.230 0.296 0.438 0.651
aat; leucyl/phenylalanyl-tRNA—protein transferase [EC:2.3.2.6] 0.056 0.493 0.910 0.976
ABC-2.A; ABC-2 type transport system ATP-binding protein -0.287 0.311 0.357 0.651
ABC-2.OM, wza; polysaccharide biosynthesis/export protein -0.285 0.310 0.360 0.651
ABC-2.P; ABC-2 type transport system permease protein -0.263 0.312 0.401 0.651
ABC-2.TX; HlyD family secretion protein -0.249 0.304 0.415 0.651
ABC.CD.A; putative ABC transport system ATP-binding protein -0.616 0.516 0.234 0.651
ABC.CD.P; putative ABC transport system permease protein -0.642 0.523 0.221 0.651
ABC.CD.TX; HlyD family secretion protein -0.566 0.561 0.314 0.651
ABC.FEV.A; iron complex transport system ATP-binding protein [EC:3.6.3.34] -0.230 0.296 0.438 0.651
ABC.FEV.P; iron complex transport system permease protein -0.230 0.296 0.438 0.651
ABC.FEV.S; iron complex transport system substrate-binding protein -0.230 0.296 0.438 0.651
ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:3.6.3.21] -2.168 1.874 0.249 0.651
ABC.PA.S; polar amino acid transport system substrate-binding protein 18.519 3411.091 0.996 0.998
ABC.SN.S; NitT/TauT family transport system substrate-binding protein -0.230 0.296 0.438 0.651
ABC.X2.A; putative ABC transport system ATP-binding protein -1.649 1.326 0.215 0.651
ABC.X2.P; putative ABC transport system permease protein -0.521 0.433 0.230 0.651
ABCB-BAC; ATP-binding cassette, subfamily B, bacterial -0.288 0.314 0.360 0.651
ABCF3; ATP-binding cassette, subfamily F, member 3 -0.230 0.296 0.438 0.651
abfA; alpha-N-arabinofuranosidase [EC:3.2.1.55] -0.691 0.615 0.263 0.651
abgT; aminobenzoyl-glutamate transport protein -0.123 0.313 0.694 0.797
abnA; arabinan endo-1,5-alpha-L-arabinosidase [EC:3.2.1.99] -0.573 0.507 0.260 0.651
ackA; acetate kinase [EC:2.7.2.1] -0.230 0.296 0.438 0.651
acm; lysozyme -0.207 0.296 0.486 0.651
ACO, acnA; aconitate hydratase [EC:4.2.1.3] -0.429 1.387 0.758 0.843
acpP; acyl carrier protein -0.367 0.318 0.251 0.651
acrA, mexA, adeI, smeD, mtrC, cmeA; membrane fusion protein, multidrug efflux system -0.216 0.278 0.438 0.651
ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3] -0.247 0.302 0.414 0.651
ACSS, acs; acetyl-CoA synthetase [EC:6.2.1.1] -0.203 0.301 0.500 0.651
ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63] -0.626 0.575 0.278 0.651
adk, AK; adenylate kinase [EC:2.7.4.3] -0.230 0.296 0.438 0.651
agaR; DeoR family transcriptional regulator, aga operon transcriptional repressor -0.731 0.848 0.390 0.651
agp; glucose-1-phosphatase [EC:3.1.3.10] -0.072 0.305 0.815 0.896
aguA; alpha-glucuronidase [EC:3.2.1.139] -0.788 0.881 0.373 0.651
aguB; N-carbamoylputrescine amidase [EC:3.5.1.53] -0.230 0.296 0.438 0.651
ahpF; alkyl hydroperoxide reductase subunit F [EC:1.6.4.-] -0.120 0.315 0.704 0.799
AIBP, nnrE; NAD(P)H-hydrate epimerase [EC:5.1.99.6] -0.230 0.296 0.438 0.651
ald; alanine dehydrogenase [EC:1.4.1.1] -0.647 0.554 0.244 0.651
algI; alginate O-acetyltransferase complex protein AlgI -0.221 0.572 0.699 0.797
alr; alanine racemase [EC:5.1.1.1] -0.230 0.296 0.438 0.651
amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] -0.230 0.296 0.438 0.651
amn; AMP nucleosidase [EC:3.2.2.4] -0.754 1.120 0.502 0.651
ampG; MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG -0.211 0.297 0.479 0.651
amt, AMT, MEP; ammonium transporter, Amt family 18.212 2925.911 0.995 0.998
AMY, amyA, malS; alpha-amylase [EC:3.2.1.1] -0.270 0.303 0.374 0.651
apbE; FAD:protein FMN transferase [EC:2.7.1.180] -0.230 0.296 0.438 0.651
APEX1; AP endonuclease 1 [EC:4.2.99.18] 0.141 0.367 0.701 0.797
apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12] -0.606 0.561 0.282 0.651
APRT, apt; adenine phosphoribosyltransferase [EC:2.4.2.7] -0.230 0.296 0.438 0.651
aqpZ; aquaporin Z 0.145 0.349 0.679 0.789
araA; L-arabinose isomerase [EC:5.3.1.4] -0.670 0.642 0.298 0.651
araD, ulaF, sgaE, sgbE; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4] -0.670 0.642 0.298 0.651
argB; acetylglutamate kinase [EC:2.7.2.8] -0.100 1.127 0.930 0.976
argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38] -0.100 1.127 0.930 0.976
argE; acetylornithine deacetylase [EC:3.5.1.16] -0.100 1.127 0.930 0.976
argF; N-succinyl-L-ornithine transcarbamylase [EC:2.1.3.11] -0.100 1.127 0.930 0.976
argG, ASS1; argininosuccinate synthase [EC:6.3.4.5] -0.100 1.127 0.930 0.976
argH, ASL; argininosuccinate lyase [EC:4.3.2.1] -0.100 1.127 0.930 0.976
argR, ahrC; transcriptional regulator of arginine metabolism -0.230 0.296 0.438 0.651
arnE; undecaprenyl phosphate-alpha-L-ara4N flippase subunit ArnE -0.685 0.544 0.210 0.651
aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19] -0.230 0.296 0.438 0.651
AROA1, aroA; chorismate mutase [EC:5.4.99.5] -0.230 0.296 0.438 0.651
aroB; 3-dehydroquinate synthase [EC:4.2.3.4] -0.230 0.296 0.438 0.651
aroC; chorismate synthase [EC:4.2.3.5] -0.230 0.296 0.438 0.651
aroE; shikimate dehydrogenase [EC:1.1.1.25] -0.230 0.296 0.438 0.651
aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10] -0.230 0.296 0.438 0.651
asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] -0.230 0.296 0.438 0.651
asnA; aspartate–ammonia ligase [EC:6.3.1.1] -0.213 0.293 0.468 0.651
asnB, ASNS; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4] 18.519 3411.091 0.996 0.998
asnC; Lrp/AsnC family transcriptional regulator, regulator for asnA, asnC and gidA -0.241 0.306 0.433 0.651
aspA; aspartate ammonia-lyase [EC:4.3.1.1] -0.259 0.322 0.423 0.651
aspB; aspartate aminotransferase [EC:2.6.1.1] -0.235 0.289 0.416 0.651
aspS; aspartyl-tRNA synthetase [EC:6.1.1.12] -0.230 0.296 0.438 0.651
ATOX1, ATX1, copZ, golB; copper chaperone -0.242 0.322 0.454 0.651
ATPF0A, atpB; F-type H+-transporting ATPase subunit a -0.230 0.296 0.438 0.651
ATPF0B, atpF; F-type H+-transporting ATPase subunit b -0.230 0.296 0.438 0.651
ATPF0C, atpE; F-type H+-transporting ATPase subunit c -0.230 0.296 0.438 0.651
ATPF1A, atpA; F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14] -0.244 0.294 0.409 0.651
ATPF1B, atpD; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14] -0.230 0.296 0.438 0.651
ATPF1D, atpH; F-type H+-transporting ATPase subunit delta -0.230 0.296 0.438 0.651
ATPF1E, atpC; F-type H+-transporting ATPase subunit epsilon -0.230 0.296 0.438 0.651
ATPF1G, atpG; F-type H+-transporting ATPase subunit gamma -0.230 0.296 0.438 0.651
AXY8, FUC95A, afcA; alpha-L-fucosidase 2 [EC:3.2.1.51] -0.161 0.278 0.562 0.689
bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] -0.230 0.296 0.438 0.651
bamD; outer membrane protein assembly factor BamD -0.230 0.296 0.438 0.651
BCP, PRXQ, DOT5; peroxiredoxin Q/BCP [EC:1.11.1.15] -0.230 0.296 0.438 0.651
bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] -0.309 0.308 0.317 0.651
bdhAB; butanol dehydrogenase [EC:1.1.1.-] -0.746 1.115 0.505 0.651
bgaB, lacA; beta-galactosidase [EC:3.2.1.23] -0.671 0.462 0.148 0.651
bglX; beta-glucosidase [EC:3.2.1.21] -0.399 0.427 0.352 0.651
bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47] -0.754 1.120 0.502 0.651
birA; BirA family transcriptional regulator, biotin operon repressor / biotin—[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] -0.230 0.296 0.438 0.651
BLMH, pepC; bleomycin hydrolase [EC:3.4.22.40] -0.224 0.296 0.452 0.651
bshA; L-malate glycosyltransferase [EC:2.4.1.-] -2.232 1.933 0.250 0.651
buk; butyrate kinase [EC:2.7.2.7] -0.147 0.329 0.655 0.768
capA, pgsA; gamma-polyglutamate biosynthesis protein CapA -0.117 0.336 0.728 0.823
carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5] -0.230 0.296 0.438 0.651
carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5] -0.232 0.301 0.441 0.651
CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16] -0.230 0.296 0.438 0.651
cas1; CRISP-associated protein Cas1 -0.588 0.445 0.188 0.651
cas2; CRISPR-associated protein Cas2 -0.588 0.445 0.188 0.651
cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 3.6.4.-] -0.789 0.881 0.372 0.651
cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1] -0.789 0.881 0.372 0.651
cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-] -0.677 0.652 0.301 0.651
cbe, mbe; cellobiose epimerase [EC:5.1.3.11] -0.588 0.587 0.318 0.651
cbpA; curved DNA-binding protein -0.231 0.318 0.469 0.651
ccrM; modification methylase [EC:2.1.1.72] -0.297 0.684 0.664 0.776
cdd, CDA; cytidine deaminase [EC:3.5.4.5] -0.230 0.296 0.438 0.651
CHO1, pssA; CDP-diacylglycerol—serine O-phosphatidyltransferase [EC:2.7.8.8] -0.230 0.296 0.438 0.651
chrA; chromate transporter -0.220 0.299 0.463 0.651
cidA; holin-like protein -0.110 0.293 0.709 0.803
cimA; (R)-citramalate synthase [EC:2.3.1.182] -0.100 1.127 0.930 0.976
citD; citrate lyase subunit gamma (acyl carrier protein) 2.304 1.989 0.248 0.651
citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34] 2.304 1.989 0.248 0.651
citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10] 2.304 1.989 0.248 0.651
citX; holo-ACP synthase [EC:2.7.7.61] 2.304 1.989 0.248 0.651
clpA; ATP-dependent Clp protease ATP-binding subunit ClpA 0.056 0.493 0.910 0.976
clpB; ATP-dependent Clp protease ATP-binding subunit ClpB -0.230 0.296 0.438 0.651
clpC; ATP-dependent Clp protease ATP-binding subunit ClpC -0.230 0.296 0.438 0.651
clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] -0.230 0.296 0.438 0.651
clpS; ATP-dependent Clp protease adaptor protein ClpS 0.056 0.493 0.910 0.976
clpX, CLPX; ATP-dependent Clp protease ATP-binding subunit ClpX -0.230 0.296 0.438 0.651
clsA_B; cardiolipin synthase A/B [EC:2.7.8.-] -0.230 0.296 0.438 0.651
cmk; CMP/dCMP kinase [EC:2.7.4.25] -0.230 0.296 0.438 0.651
coaBC, dfp; phosphopantothenoylcysteine decarboxylase / phosphopantothenate—cysteine ligase [EC:4.1.1.36 6.3.2.5] -0.213 0.298 0.477 0.651
coaE; dephospho-CoA kinase [EC:2.7.1.24] -0.228 0.308 0.459 0.651
coaW; type II pantothenate kinase [EC:2.7.1.33] -0.219 0.301 0.468 0.651
coaX; type III pantothenate kinase [EC:2.7.1.33] -0.754 1.120 0.502 0.651
cobA, btuR; cob(I)alamin adenosyltransferase [EC:2.5.1.17] -0.221 0.572 0.699 0.797
cobC, phpB; alpha-ribazole phosphatase [EC:3.1.3.73] -0.680 0.538 0.208 0.651
cobN; cobaltochelatase CobN [EC:6.6.1.2] -0.341 0.419 0.416 0.651
cobP, cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62] -0.680 0.538 0.208 0.651
comEB; dCMP deaminase [EC:3.5.4.12] -0.230 0.296 0.438 0.651
comEC; competence protein ComEC -0.230 0.296 0.438 0.651
comM; magnesium chelatase family protein -0.243 0.294 0.409 0.651
copB; Cu2+-exporting ATPase [EC:3.6.3.4] -0.224 0.285 0.434 0.651
corA; magnesium transporter -0.230 0.296 0.438 0.651
cpdB; 2’,3’-cyclic-nucleotide 2’-phosphodiesterase / 3’-nucleotidase [EC:3.1.4.16 3.1.3.6] -0.285 0.310 0.360 0.651
crcB, FEX; fluoride exporter -0.239 0.315 0.449 0.651
CS, gltA; citrate synthase [EC:2.3.3.1] 18.519 3411.091 0.996 0.998
csm1, cas10; CRISPR-associated protein Csm1 -1.447 1.576 0.360 0.651
csm2; CRISPR-associated protein Csm2 -1.447 1.576 0.360 0.651
csm3; CRISPR-associated protein Csm3 -1.447 1.576 0.360 0.651
csn1, cas9; CRISPR-associated endonuclease Csn1 [EC:3.1.-.-] -0.460 0.462 0.321 0.651
csxA; exo-1,4-beta-D-glucosaminidase [EC:3.2.1.165] -2.232 1.933 0.250 0.651
cusA, silA; Cu(I)/Ag(I) efflux system membrane protein CusA/SilA 0.153 0.466 0.742 0.834
cusB, silB; membrane fusion protein, Cu(I)/Ag(I) efflux system 0.045 0.522 0.932 0.976
cutC; copper homeostasis protein -0.277 0.305 0.364 0.651
cvrA, nhaP2; cell volume regulation protein A -1.146 1.935 0.555 0.683
cydA; cytochrome bd ubiquinol oxidase subunit I [EC:1.10.3.14] -0.230 0.296 0.438 0.651
cydB; cytochrome bd ubiquinol oxidase subunit II [EC:1.10.3.14] -0.230 0.296 0.438 0.651
cynR; LysR family transcriptional regulator, cyn operon transcriptional activator -0.330 0.504 0.514 0.651
cynT, can; carbonic anhydrase [EC:4.2.1.1] -0.169 0.333 0.614 0.731
cysC; adenylylsulfate kinase [EC:2.7.1.25] -0.754 1.120 0.502 0.651
cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4] -0.754 1.120 0.502 0.651
cysE; serine O-acetyltransferase [EC:2.3.1.30] -0.157 0.290 0.590 0.717
cysH; phosphoadenosine phosphosulfate reductase [EC:1.8.4.8 1.8.4.10] 18.519 3411.091 0.996 0.998
cysK; cysteine synthase A [EC:2.5.1.47] -0.260 0.313 0.407 0.651
cysN; sulfate adenylyltransferase subunit 1 [EC:2.7.7.4] -0.754 1.120 0.502 0.651
cysQ, MET22, BPNT1; 3’(2’), 5’-bisphosphate nucleotidase [EC:3.1.3.7] -0.754 1.120 0.502 0.651
cytR; LacI family transcriptional regulator, repressor for deo operon, udp, cdd, tsx, nupC, and nupG 0.151 1.352 0.911 0.976
czcA; cobalt-zinc-cadmium resistance protein CzcA 0.470 0.526 0.372 0.651
czcB; membrane fusion protein, cobalt-zinc-cadmium efflux system 18.519 3411.091 0.996 0.998
dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-] -0.288 0.314 0.360 0.651
dam; DNA adenine methylase [EC:2.1.1.72] -0.174 0.353 0.623 0.740
dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7] -0.230 0.296 0.438 0.651
dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8] -0.230 0.296 0.438 0.651
dapdh; diaminopimelate dehydrogenase [EC:1.4.1.16] -0.228 0.293 0.436 0.651
dapF; diaminopimelate epimerase [EC:5.1.1.7] -0.394 0.395 0.320 0.651
dcp; peptidyl-dipeptidase Dcp [EC:3.4.15.5] -0.233 0.311 0.453 0.651
dcuA; anaerobic C4-dicarboxylate transporter DcuA -0.318 0.477 0.505 0.651
dcuB; anaerobic C4-dicarboxylate transporter DcuB -0.221 0.572 0.699 0.797
ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] -0.230 0.296 0.438 0.651
deaD, cshA; ATP-dependent RNA helicase DeaD [EC:3.6.4.13] -0.230 0.296 0.438 0.651
deoC, DERA; deoxyribose-phosphate aldolase [EC:4.1.2.4] -0.230 0.296 0.438 0.651
dexA; dextranase [EC:3.2.1.11] -0.282 0.509 0.580 0.706
dfx; superoxide reductase [EC:1.15.1.2] -0.166 0.321 0.605 0.723
dgt; dGTPase [EC:3.1.5.1] -0.230 0.296 0.438 0.651
DHFR, folA; dihydrofolate reductase [EC:1.5.1.3] -0.201 0.284 0.481 0.651
dinB; DNA polymerase IV [EC:2.7.7.7] -0.230 0.296 0.438 0.651
dinD; DNA-damage-inducible protein D -0.195 0.637 0.759 0.844
djlA; DnaJ like chaperone protein -0.174 0.327 0.596 0.722
DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4] -0.190 0.321 0.556 0.683
dnaA; chromosomal replication initiator protein -0.230 0.296 0.438 0.651
dnaB; replicative DNA helicase [EC:3.6.4.12] -0.230 0.296 0.438 0.651
dnaC; DNA replication protein DnaC -17.599 3454.822 0.996 0.998
dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] -0.230 0.296 0.438 0.651
dnaG; DNA primase [EC:2.7.7.-] -0.230 0.296 0.438 0.651
dnaJ; molecular chaperone DnaJ -0.230 0.296 0.438 0.651
dnaK, HSPA9; molecular chaperone DnaK -0.230 0.296 0.438 0.651
dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] -0.230 0.296 0.438 0.651
dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] -0.218 0.290 0.455 0.651
dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] -0.230 0.296 0.438 0.651
dndC; DNA sulfur modification protein DndC 2.304 1.989 0.248 0.651
dndD; DNA sulfur modification protein DndD 2.332 1.962 0.236 0.651
dndE; DNA sulfur modification protein DndE 2.304 1.989 0.248 0.651
DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] -0.244 0.306 0.427 0.651
DNPEP; aspartyl aminopeptidase [EC:3.4.11.21] 18.519 3411.091 0.996 0.998
DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83] -0.230 0.296 0.438 0.651
dpo; DNA polymerase bacteriophage-type [EC:2.7.7.7] 0.358 0.550 0.516 0.651
DPP3; dipeptidyl-peptidase III [EC:3.4.14.4] -0.230 0.296 0.438 0.651
DPP4, CD26; dipeptidyl-peptidase 4 [EC:3.4.14.5] -0.230 0.296 0.438 0.651
dps; starvation-inducible DNA-binding protein -0.222 0.303 0.464 0.651
dsbD; thiol:disulfide interchange protein DsbD [EC:1.8.1.8] -0.230 0.296 0.438 0.651
dtd, DTD1; D-tyrosyl-tRNA(Tyr) deacylase [EC:3.1.-.-] -0.230 0.296 0.438 0.651
dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23] -0.230 0.296 0.438 0.651
dxr; 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267] -0.230 0.296 0.438 0.651
dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7] -0.211 0.305 0.489 0.651
E1.1.1.40, maeB; malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40] -0.230 0.296 0.438 0.651
E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] -0.178 0.295 0.546 0.680
E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] -0.123 0.286 0.667 0.778
E1.4.1.4, gdhA; glutamate dehydrogenase (NADP+) [EC:1.4.1.4] -0.154 0.290 0.596 0.722
E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72] -0.359 0.322 0.266 0.651
E2.1.1.77, pcm; protein-L-isoaspartate(D-aspartate) O-methyltransferase [EC:2.1.1.77] -0.137 0.613 0.823 0.900
E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1] -0.234 0.306 0.446 0.651
E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6] -0.548 0.584 0.350 0.651
E2.2.1.6S, ilvH, ilvN; acetolactate synthase I/III small subunit [EC:2.2.1.6] -0.548 0.584 0.350 0.651
E2.3.1.54, pflD; formate C-acetyltransferase [EC:2.3.1.54] -0.215 0.295 0.468 0.651
E2.3.1.8, pta; phosphate acetyltransferase [EC:2.3.1.8] -0.230 0.296 0.438 0.651
E2.4.1.20; cellobiose phosphorylase [EC:2.4.1.20] 0.154 1.349 0.909 0.976
E2.4.2.21, cobU, cobT; nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21] -0.680 0.538 0.208 0.651
E2.5.1.56, neuB; N-acetylneuraminate synthase [EC:2.5.1.56] -2.232 1.933 0.250 0.651
E2.6.1.11, argD; acetylornithine aminotransferase [EC:2.6.1.11] -0.100 1.127 0.930 0.976
E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42] -0.230 0.296 0.438 0.651
E2.6.1.83; LL-diaminopimelate aminotransferase [EC:2.6.1.83] -0.394 0.395 0.320 0.651
E2.7.1.4, scrK; fructokinase [EC:2.7.1.4] -0.239 0.302 0.431 0.651
E2.7.1.71, aroK, aroL; shikimate kinase [EC:2.7.1.71] -0.230 0.296 0.438 0.651
E2.7.4.8, gmk; guanylate kinase [EC:2.7.4.8] -0.230 0.296 0.438 0.651
E2.7.7.24, rfbA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] -0.230 0.296 0.438 0.651
E2.7.7.3A, coaD, kdtB; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3] -0.230 0.296 0.438 0.651
E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41] -0.230 0.296 0.438 0.651
E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26] -0.680 0.538 0.208 0.651
E3.1.1.11; pectinesterase [EC:3.1.1.11] -0.674 0.651 0.302 0.651
E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2] -0.138 0.295 0.642 0.755
E3.1.11.5; exodeoxyribonuclease V [EC:3.1.11.5] -0.754 1.120 0.502 0.651
E3.1.21.4; type II restriction enzyme [EC:3.1.21.4] -0.343 0.461 0.459 0.651
E3.1.3.1, phoA, phoB; alkaline phosphatase [EC:3.1.3.1] -0.400 0.466 0.392 0.651
E3.1.3.48; protein-tyrosine phosphatase [EC:3.1.3.48] -0.237 0.301 0.432 0.651
E3.1.3.5; 5’-nucleotidase [EC:3.1.3.5] -0.219 0.301 0.468 0.651
E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46] -0.647 0.496 0.194 0.651
E3.1.6.1, aslA; arylsulfatase [EC:3.1.6.1] -0.131 0.339 0.701 0.797
E3.2.1.17; lysozyme [EC:3.2.1.17] 0.038 0.447 0.932 0.976
E3.2.1.1A; alpha-amylase [EC:3.2.1.1] -0.230 0.296 0.438 0.651
E3.2.1.22B, galA, rafA; alpha-galactosidase [EC:3.2.1.22] -0.168 0.287 0.561 0.689
E3.2.1.4; endoglucanase [EC:3.2.1.4] 18.519 3411.091 0.996 0.998
E3.2.1.8, xynA; endo-1,4-beta-xylanase [EC:3.2.1.8] 18.519 3411.091 0.996 0.998
E3.2.1.89; arabinogalactan endo-1,4-beta-galactosidase [EC:3.2.1.89] -0.483 0.529 0.363 0.651
E3.4.21.102, prc, ctpA; carboxyl-terminal processing protease [EC:3.4.21.102] -0.230 0.296 0.438 0.651
E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1] -0.260 0.336 0.441 0.651
E3.5.2.10; creatinine amidohydrolase [EC:3.5.2.10] -2.232 1.933 0.250 0.651
E3.6.1.22, NUDT12, nudC; NAD+ diphosphatase [EC:3.6.1.22] -0.230 0.296 0.438 0.651
E3.6.3.8; Ca2+-transporting ATPase [EC:3.6.3.8] -0.156 0.300 0.605 0.723
E4.1.1.49, pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49] -0.230 0.296 0.438 0.651
E4.1.3.3, nanA, NPL; N-acetylneuraminate lyase [EC:4.1.3.3] -0.206 0.295 0.486 0.651
E4.2.1.2A, fumA, fumB; fumarate hydratase, class I [EC:4.2.1.2] -0.230 0.296 0.438 0.651
E4.2.1.2AA, fumA; fumarate hydratase subunit alpha [EC:4.2.1.2] -0.221 0.572 0.699 0.797
E4.2.1.2AB, fumB; fumarate hydratase subunit beta [EC:4.2.1.2] -0.221 0.572 0.699 0.797
E4.2.1.46, rfbB, rffG; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] -0.230 0.296 0.438 0.651
E4.3.1.17, sdaA, sdaB, tdcG; L-serine dehydratase [EC:4.3.1.17] -0.230 0.296 0.438 0.651
E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19] -0.378 0.462 0.414 0.651
E5.1.3.6; UDP-glucuronate 4-epimerase [EC:5.1.3.6] -0.057 0.574 0.921 0.976
E5.2.1.8; peptidylprolyl isomerase [EC:5.2.1.8] -0.080 0.342 0.815 0.896
E6.3.5.1, NADSYN1, QNS1, nadE; NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1] -0.230 0.296 0.438 0.651
E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2] -0.230 0.296 0.438 0.651
eamB; cysteine/O-acetylserine efflux protein 0.092 1.404 0.948 0.986
EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17] -0.230 0.296 0.438 0.651
eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] -0.628 0.582 0.282 0.651
efp; elongation factor P -0.230 0.296 0.438 0.651
EIF1, SUI1; translation initiation factor 1 -0.754 1.120 0.502 0.651
elaA; ElaA protein 2.304 1.989 0.248 0.651
emrA; membrane fusion protein, multidrug efflux system 18.519 3411.091 0.996 0.998
ENDOG; endonuclease G, mitochondrial -0.199 0.305 0.515 0.651
engA, der; GTPase -0.230 0.296 0.438 0.651
engB; GTP-binding protein -0.230 0.296 0.438 0.651
ENO, eno; enolase [EC:4.2.1.11] -0.230 0.296 0.438 0.651
entC; isochorismate synthase [EC:5.4.4.2] -0.230 0.296 0.438 0.651
epsD; glycosyltransferase EpsD [EC:2.4.-.-] 0.358 0.550 0.516 0.651
eptC; heptose-I-phosphate ethanolaminephosphotransferase [EC:2.7.8.-] -0.236 0.284 0.407 0.651
era, ERAL1; GTPase -0.230 0.296 0.438 0.651
ermC, ermA; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184] 0.141 0.367 0.701 0.797
exbB; biopolymer transport protein ExbB -0.225 0.298 0.452 0.651
exuT; MFS transporter, ACS family, hexuronate transporter -0.692 0.616 0.263 0.651
fabB; 3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41] -0.741 0.488 0.131 0.651
fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] -0.230 0.296 0.438 0.651
fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] -0.230 0.296 0.438 0.651
fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] -0.342 0.306 0.265 0.651
fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] -0.223 0.335 0.506 0.651
fabI; enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10] -0.219 0.301 0.468 0.651
fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] -0.741 0.488 0.131 0.651
fadL; long-chain fatty acid transport protein -0.642 0.547 0.242 0.651
FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] -0.230 0.296 0.438 0.651
FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] -0.230 0.296 0.438 0.651
FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] -0.230 0.296 0.438 0.651
fbp3; fructose-1,6-bisphosphatase III [EC:3.1.3.11] -0.230 0.296 0.438 0.651
fecA; Fe(3+) dicitrate transport protein -0.202 0.360 0.576 0.703
feoB; ferrous iron transport protein B -0.214 0.282 0.449 0.651
fes; enterochelin esterase and related enzymes -0.206 0.316 0.516 0.651
fhs; formate–tetrahydrofolate ligase [EC:6.3.4.3] -0.263 0.312 0.401 0.651
fic; cell filamentation protein -0.213 0.305 0.486 0.651
fixA, etfB; electron transfer flavoprotein beta subunit -0.230 0.296 0.438 0.651
fixB, etfA; electron transfer flavoprotein alpha subunit -0.230 0.296 0.438 0.651
fklB; FKBP-type peptidyl-prolyl cis-trans isomerase FklB [EC:5.2.1.8] -0.223 0.293 0.448 0.651
fldA, nifF, isiB; flavodoxin I -0.201 0.284 0.481 0.651
FLOT; flotillin -2.232 1.933 0.250 0.651
folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:4.1.2.25 5.1.99.8 1.13.11.81] -0.230 0.296 0.438 0.651
folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] -0.230 0.296 0.438 0.651
folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] -0.230 0.296 0.438 0.651
folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3] -0.240 0.304 0.431 0.651
folP; dihydropteroate synthase [EC:2.5.1.15] -0.230 0.296 0.438 0.651
frr, MRRF, RRF; ribosome recycling factor -0.230 0.296 0.438 0.651
fruA; fructan beta-fructosidase [EC:3.2.1.80] -0.268 0.313 0.394 0.651
fsr; MFS transporter, FSR family, fosmidomycin resistance protein -0.081 0.335 0.809 0.893
FTCD; glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase [EC:2.1.2.5 4.3.1.4] -0.162 0.333 0.626 0.741
ftnA, ftn; ferritin [EC:1.16.3.2] -0.219 0.301 0.468 0.651
ftsA; cell division protein FtsA -0.230 0.296 0.438 0.651
ftsE; cell division transport system ATP-binding protein -0.230 0.296 0.438 0.651
ftsH, hflB; cell division protease FtsH [EC:3.4.24.-] -0.230 0.296 0.438 0.651
ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4] -0.229 0.320 0.476 0.651
ftsK, spoIIIE; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family -0.230 0.296 0.438 0.651
ftsQ; cell division protein FtsQ -0.230 0.296 0.438 0.651
ftsW, spoVE; cell division protein FtsW -0.230 0.296 0.438 0.651
ftsX; cell division transport system permease protein -0.230 0.296 0.438 0.651
ftsY; fused signal recognition particle receptor -0.230 0.296 0.438 0.651
ftsZ; cell division protein FtsZ -0.241 0.294 0.412 0.651
FUCA; alpha-L-fucosidase [EC:3.2.1.51] -0.246 0.300 0.413 0.651
fucP; MFS transporter, FHS family, L-fucose permease -0.286 0.297 0.338 0.651
fur, zur, furB; Fur family transcriptional regulator, ferric uptake regulator -0.264 0.311 0.398 0.651
fusA, GFM, EFG; elongation factor G -0.230 0.296 0.438 0.651
galE, GALE; UDP-glucose 4-epimerase [EC:5.1.3.2] -0.230 0.296 0.438 0.651
galK; galactokinase [EC:2.7.1.6] -0.224 0.269 0.406 0.651
galM, GALM; aldose 1-epimerase [EC:5.1.3.3] -0.243 0.306 0.429 0.651
GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12] -0.230 0.296 0.438 0.651
GARS, glyS1; glycyl-tRNA synthetase [EC:6.1.1.14] -0.230 0.296 0.438 0.651
GBA, srfJ; glucosylceramidase [EC:3.2.1.45] 0.151 1.352 0.911 0.976
GBE1, glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18] -0.230 0.296 0.438 0.651
GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16] -0.201 0.284 0.481 0.651
gcpE, ispG; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3] -0.230 0.296 0.438 0.651
gcvH, GCSH; glycine cleavage system H protein -0.190 0.321 0.556 0.683
gcvPA; glycine dehydrogenase subunit 1 [EC:1.4.4.2] -0.190 0.321 0.556 0.683
gcvPB; glycine dehydrogenase subunit 2 [EC:1.4.4.2] -0.190 0.321 0.556 0.683
gcvT, AMT; aminomethyltransferase [EC:2.1.2.10] -0.190 0.321 0.556 0.683
GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29] -0.230 0.296 0.438 0.651
gidA, mnmG, MTO1; tRNA uridine 5-carboxymethylaminomethyl modification enzyme -0.230 0.296 0.438 0.651
gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170] -0.230 0.296 0.438 0.651
glf; UDP-galactopyranose mutase [EC:5.4.99.9] -0.337 0.418 0.421 0.651
glgA; starch synthase [EC:2.4.1.21] -0.230 0.296 0.438 0.651
glk; glucokinase [EC:2.7.1.2] -0.268 0.292 0.361 0.651
glmE, mutE, mamB; methylaspartate mutase epsilon subunit [EC:5.4.99.1] -0.221 0.572 0.699 0.797
glmS, GFPT; glucosamine—fructose-6-phosphate aminotransferase (isomerizing) [EC:2.6.1.16] -0.243 0.311 0.436 0.651
glmS, mutS, mamA; methylaspartate mutase sigma subunit [EC:5.4.99.1] -0.221 0.572 0.699 0.797
glnA, GLUL; glutamine synthetase [EC:6.3.1.2] -0.204 0.294 0.489 0.651
glnB; nitrogen regulatory protein P-II 1 18.519 3411.091 0.996 0.998
GLO1, gloA; lactoylglutathione lyase [EC:4.4.1.5] -1.045 0.919 0.257 0.651
glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3] -0.228 0.331 0.492 0.651
glpB; glycerol-3-phosphate dehydrogenase subunit B [EC:1.1.5.3] -0.228 0.331 0.492 0.651
glpC; glycerol-3-phosphate dehydrogenase subunit C [EC:1.1.5.3] -0.228 0.331 0.492 0.651
GLPF; glycerol uptake facilitator protein -0.075 0.341 0.826 0.900
glpK, GK; glycerol kinase [EC:2.7.1.30] -0.075 0.341 0.826 0.900
glpT; MFS transporter, OPA family, glycerol-3-phosphate transporter -0.591 0.565 0.297 0.651
gltB; glutamate synthase (NADPH/NADH) large chain [EC:1.4.1.13 1.4.1.14] 18.519 3411.091 0.996 0.998
gltD; glutamate synthase (NADPH/NADH) small chain [EC:1.4.1.13 1.4.1.14] -0.324 0.318 0.311 0.651
glxK, garK; glycerate 2-kinase [EC:2.7.1.165] -0.206 0.323 0.524 0.659
glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1] -0.230 0.296 0.438 0.651
gmd, GMDS; GDPmannose 4,6-dehydratase [EC:4.2.1.47] -0.230 0.296 0.438 0.651
gmhA, lpcA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28] 18.519 3411.091 0.996 0.998
gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83] 18.519 3411.091 0.996 0.998
gmuG; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78] -0.658 0.589 0.265 0.651
gph; phosphoglycolate phosphatase [EC:3.1.3.18] -0.223 0.280 0.427 0.651
GPI, pgi; glucose-6-phosphate isomerase [EC:5.3.1.9] -0.230 0.296 0.438 0.651
gpmB; probable phosphoglycerate mutase [EC:5.4.2.12] -0.262 0.309 0.398 0.651
gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12] -0.249 0.316 0.432 0.651
gpr; L-glyceraldehyde 3-phosphate reductase [EC:1.1.1.-] 0.179 0.522 0.732 0.826
gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94] -0.230 0.296 0.438 0.651
gpx; glutathione peroxidase [EC:1.11.1.9] -0.203 0.301 0.502 0.651
greA; transcription elongation factor GreA -0.248 0.296 0.404 0.651
groEL, HSPD1; chaperonin GroEL -0.230 0.296 0.438 0.651
groES, HSPE1; chaperonin GroES -0.230 0.296 0.438 0.651
GRPE; molecular chaperone GrpE -0.230 0.296 0.438 0.651
guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] -0.230 0.296 0.438 0.651
gyrA; DNA gyrase subunit A [EC:5.99.1.3] -0.230 0.296 0.438 0.651
gyrB; DNA gyrase subunit B [EC:5.99.1.3] -0.230 0.296 0.438 0.651
HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21] -0.230 0.296 0.438 0.651
hcp; hydroxylamine reductase [EC:1.7.99.1] -0.206 0.301 0.494 0.651
hddA; D-glycero-alpha-D-manno-heptose-7-phosphate kinase [EC:2.7.1.168] 18.519 3411.091 0.996 0.998
hemD, UROS; uroporphyrinogen-III synthase [EC:4.2.1.75] -0.248 0.296 0.403 0.651
hemK, prmC, HEMK; release factor glutamine methyltransferase [EC:2.1.1.297] -0.230 0.296 0.438 0.651
hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3] -0.227 0.294 0.441 0.651
HEXA_B; hexosaminidase [EC:3.2.1.52] -0.212 0.270 0.432 0.651
hflX; GTPase -0.230 0.296 0.438 0.651
higA; HTH-type transcriptional regulator / antitoxin HigA -0.106 0.353 0.765 0.849
higB-1; toxin HigB-1 -2.232 1.933 0.250 0.651
HINT1, hinT, hit; histidine triad (HIT) family protein -0.230 0.296 0.438 0.651
hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1] -0.014 0.330 0.966 0.998
hipO; hippurate hydrolase [EC:3.5.1.32] -1.546 2.070 0.456 0.651
hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16] -0.100 1.127 0.930 0.976
hisB; imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase [EC:4.2.1.19 3.1.3.15] -0.100 1.127 0.930 0.976
hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9] -0.159 0.284 0.576 0.703
hisD; histidinol dehydrogenase [EC:1.1.1.23] -0.100 1.127 0.930 0.976
hisF; cyclase [EC:4.1.3.-] -0.100 1.127 0.930 0.976
hisG; ATP phosphoribosyltransferase [EC:2.4.2.17] -0.100 1.127 0.930 0.976
hisH; glutamine amidotransferase [EC:2.4.2.-] -0.100 1.127 0.930 0.976
hisIE; phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase [EC:3.6.1.31 3.5.4.19] -0.100 1.127 0.930 0.976
hlpA, ompH; outer membrane protein -0.230 0.296 0.438 0.651
hlyIII; hemolysin III -0.202 0.335 0.547 0.680
holA; DNA polymerase III subunit delta [EC:2.7.7.7] -0.230 0.296 0.438 0.651
holB; DNA polymerase III subunit delta’ [EC:2.7.7.7] -0.230 0.296 0.438 0.651
hppA; K(+)-stimulated pyrophosphate-energized sodium pump [EC:3.6.1.1] -0.240 0.317 0.450 0.651
hprA; glycerate dehydrogenase [EC:1.1.1.29] -0.230 0.296 0.438 0.651
hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8] -0.230 0.296 0.438 0.651
hsdM; type I restriction enzyme M protein [EC:2.1.1.72] -0.227 0.303 0.455 0.651
hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3] -0.273 0.327 0.405 0.651
hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3] -0.246 0.299 0.411 0.651
hslR; ribosome-associated heat shock protein Hsp15 -0.230 0.296 0.438 0.651
HSP20; HSP20 family protein -0.254 0.323 0.433 0.651
HSP90A, htpG; molecular chaperone HtpG -0.230 0.296 0.438 0.651
htpX; heat shock protein HtpX [EC:3.4.24.-] -0.446 0.424 0.294 0.651
hupB; DNA-binding protein HU-beta -0.250 0.294 0.397 0.651
hutH, HAL; histidine ammonia-lyase [EC:4.3.1.3] -0.162 0.333 0.626 0.741
hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7] -0.162 0.333 0.626 0.741
hutU, UROC1; urocanate hydratase [EC:4.2.1.49] -0.162 0.333 0.626 0.741
hya; hyaluronoglucosaminidase [EC:3.2.1.35] -0.247 0.317 0.437 0.651
IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5] -0.220 0.308 0.477 0.651
icmF; isobutyryl-CoA mutase [EC:5.4.99.13] -0.228 0.317 0.474 0.651
IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42] -0.429 1.387 0.758 0.843
idnO; gluconate 5-dehydrogenase [EC:1.1.1.69] -0.542 0.584 0.355 0.651
ihfA, himA; integration host factor subunit alpha -0.364 0.544 0.505 0.651
ilvC; ketol-acid reductoisomerase [EC:1.1.1.86] -0.548 0.584 0.350 0.651
ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9] -0.548 0.584 0.350 0.651
IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205] -0.230 0.296 0.438 0.651
ina; immune inhibitor A [EC:3.4.24.-] -0.257 0.319 0.422 0.651
infA; translation initiation factor IF-1 -0.230 0.296 0.438 0.651
infB, MTIF2; translation initiation factor IF-2 -0.230 0.296 0.438 0.651
infC, MTIF3; translation initiation factor IF-3 -0.230 0.296 0.438 0.651
inlA; internalin A -0.221 0.572 0.699 0.797
INO1, ISYNA1; myo-inositol-1-phosphate synthase [EC:5.5.1.4] -0.144 0.334 0.667 0.778
INV, sacA; beta-fructofuranosidase [EC:3.2.1.26] -0.496 0.487 0.311 0.651
ispB; octaprenyl-diphosphate synthase [EC:2.5.1.90] -0.230 0.296 0.438 0.651
ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60] -0.232 0.307 0.452 0.651
ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148] -0.230 0.296 0.438 0.651
ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12] -0.230 0.296 0.438 0.651
ispH, lytB; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4] -0.230 0.296 0.438 0.651
K00243; uncharacterized protein -0.230 0.296 0.438 0.651
K01163; uncharacterized protein -0.113 0.281 0.688 0.797
K02477; two-component system, LytTR family, response regulator -0.221 0.571 0.700 0.797
K02481; two-component system, NtrC family, response regulator 2.304 1.989 0.248 0.651
K06871; uncharacterized protein -0.311 0.327 0.343 0.651
K06872; uncharacterized protein -0.253 0.518 0.626 0.741
K06885; uncharacterized protein -0.115 0.303 0.705 0.799
K06889; uncharacterized protein -0.239 0.319 0.455 0.651
K06890; uncharacterized protein -0.230 0.296 0.438 0.651
K06904; uncharacterized protein 0.358 0.550 0.516 0.651
K06915; uncharacterized protein -17.599 3454.822 0.996 0.998
K06921; uncharacterized protein -0.594 0.750 0.429 0.651
K06926; uncharacterized protein -0.511 0.365 0.164 0.651
K06950; uncharacterized protein -0.225 0.298 0.452 0.651
K06973; uncharacterized protein -0.754 1.120 0.502 0.651
K06975; uncharacterized protein -0.428 0.414 0.303 0.651
K07000; uncharacterized protein -0.219 0.301 0.469 0.651
K07001; NTE family protein -0.294 0.304 0.334 0.651
K07003; uncharacterized protein -0.248 0.345 0.474 0.651
K07005; uncharacterized protein -0.229 0.336 0.497 0.651
K07007; uncharacterized protein -0.226 0.306 0.462 0.651
K07011; uncharacterized protein -0.246 0.298 0.412 0.651
K07014; uncharacterized protein -0.335 0.976 0.732 0.826
K07025; putative hydrolase of the HAD superfamily -0.232 0.310 0.456 0.651
K07027; glycosyltransferase 2 family protein -0.230 0.296 0.438 0.651
K07037; uncharacterized protein -0.230 0.296 0.438 0.651
K07043; uncharacterized protein -0.754 1.120 0.502 0.651
K07052; uncharacterized protein -0.250 0.275 0.365 0.651
K07054; uncharacterized protein -0.049 0.358 0.891 0.966
K07058; membrane protein -0.229 0.309 0.461 0.651
K07078; uncharacterized protein -17.599 3454.822 0.996 0.998
K07082; UPF0755 protein -0.230 0.296 0.438 0.651
K07085; putative transport protein -0.247 0.292 0.398 0.651
K07088; uncharacterized protein -0.089 0.344 0.796 0.879
K07090; uncharacterized protein -0.307 0.429 0.475 0.651
K07095; uncharacterized protein -0.256 0.314 0.416 0.651
K07098; uncharacterized protein -0.230 0.306 0.452 0.651
K07126; uncharacterized protein -0.275 0.524 0.601 0.723
K07133; uncharacterized protein -0.250 0.312 0.424 0.651
K07137; uncharacterized protein -0.230 0.296 0.438 0.651
K07139; uncharacterized protein -0.228 0.293 0.436 0.651
K07150; uncharacterized protein -0.754 1.120 0.502 0.651
K07164; uncharacterized protein -0.230 0.296 0.438 0.651
K07166; ACT domain-containing protein 18.519 3411.091 0.996 0.998
K07220; uncharacterized protein 2.304 1.989 0.248 0.651
K07270; glycosyl transferase, family 25 0.358 0.550 0.516 0.651
K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72] 0.248 1.294 0.848 0.924
K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72] -0.297 0.684 0.664 0.776
K07387; putative metalloprotease [EC:3.4.24.-] -0.247 0.316 0.435 0.651
K07454; putative restriction endonuclease -0.001 1.049 0.999 0.999
K07481; transposase, IS5 family -0.256 0.444 0.566 0.693
K07483; transposase -0.398 0.499 0.426 0.651
K07484; transposase 18.519 3411.091 0.996 0.998
K07491; putative transposase 2.304 1.989 0.248 0.651
K07496; putative transposase 2.304 1.989 0.248 0.651
K07504; predicted type IV restriction endonuclease 0.054 0.493 0.913 0.976
K07727; putative transcriptional regulator -0.211 0.577 0.715 0.809
K07729; putative transcriptional regulator -0.054 0.371 0.885 0.961
K08303; putative protease [EC:3.4.-.-] -0.225 0.301 0.457 0.651
K08884; serine/threonine protein kinase, bacterial [EC:2.7.11.1] -0.098 0.320 0.761 0.844
K08961; chondroitin-sulfate-ABC endolyase/exolyase [EC:4.2.2.20 4.2.2.21] -0.677 0.652 0.301 0.651
K08987; putative membrane protein 0.038 0.353 0.913 0.976
K08998; uncharacterized protein -0.224 0.269 0.406 0.651
K08999; uncharacterized protein -0.216 0.297 0.468 0.651
K09117; uncharacterized protein -0.480 0.429 0.265 0.651
K09124; uncharacterized protein 0.092 1.404 0.948 0.986
K09125; uncharacterized protein -0.219 0.301 0.468 0.651
K09137; uncharacterized protein 0.358 0.550 0.516 0.651
K09155; uncharacterized protein -0.226 0.296 0.445 0.651
K09157; uncharacterized protein 18.519 3411.091 0.996 0.998
K09704; uncharacterized protein -0.223 0.285 0.435 0.651
K09797; uncharacterized protein -0.400 0.427 0.350 0.651
K09805; uncharacterized protein -0.659 0.562 0.243 0.651
K09861; uncharacterized protein -0.230 0.296 0.438 0.651
K09922; uncharacterized protein 18.519 3411.091 0.996 0.998
K09924; uncharacterized protein -0.280 0.500 0.577 0.703
K09955; uncharacterized protein -0.691 0.615 0.263 0.651
K09973; uncharacterized protein 0.151 1.352 0.911 0.976
K09975; uncharacterized protein -0.172 0.359 0.633 0.746
K13652; AraC family transcriptional regulator -2.232 1.933 0.250 0.651
K15977; putative oxidoreductase -0.050 0.281 0.859 0.934
KAE1, tsaD, QRI7; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234] -0.230 0.296 0.438 0.651
KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] -0.230 0.296 0.438 0.651
kbl, GCAT; glycine C-acetyltransferase [EC:2.3.1.29] -0.323 0.372 0.387 0.651
kch, trkA, mthK, pch; voltage-gated potassium channel 0.358 0.550 0.516 0.651
kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45] -0.577 0.590 0.329 0.651
kdpA; K+-transporting ATPase ATPase A chain [EC:3.6.3.12] 2.304 1.989 0.248 0.651
kdpB; K+-transporting ATPase ATPase B chain [EC:3.6.3.12] 2.304 1.989 0.248 0.651
kdpC; K+-transporting ATPase ATPase C chain [EC:3.6.3.12] 2.304 1.989 0.248 0.651
kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] 2.304 1.989 0.248 0.651
kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55] -0.230 0.296 0.438 0.651
kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38] -0.243 0.292 0.407 0.651
kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45] -0.232 0.301 0.441 0.651
kdsD, kpsF; arabinose-5-phosphate isomerase [EC:5.3.1.13] -0.230 0.296 0.438 0.651
kdtA, waaA; 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.4.99.12 2.4.99.13 2.4.99.14 2.4.99.15] -0.230 0.296 0.438 0.651
kduI; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase [EC:5.3.1.17] -0.676 0.652 0.302 0.651
korA, oorA, oforA; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11] -0.241 0.306 0.433 0.651
korB, oorB, oforB; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11] -0.241 0.306 0.433 0.651
korC, oorC; 2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3] -0.230 0.296 0.438 0.651
korD, oorD; 2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3] -0.230 0.296 0.438 0.651
ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182] -0.230 0.296 0.438 0.651
kup; KUP system potassium uptake protein -0.098 0.312 0.753 0.841
lacA; galactoside O-acetyltransferase [EC:2.3.1.18] -0.062 0.367 0.865 0.940
lacI, galR; LacI family transcriptional regulator -0.239 0.298 0.424 0.651
lacZ; beta-galactosidase [EC:3.2.1.23] -0.222 0.291 0.446 0.651
LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4] -0.222 0.299 0.458 0.651
lctP; lactate permease -0.289 0.546 0.598 0.723
ldhA; D-lactate dehydrogenase [EC:1.1.1.28] -0.088 0.288 0.760 0.844
lemA; LemA protein -0.230 0.290 0.428 0.651
lepA; GTP-binding protein LepA -0.230 0.296 0.438 0.651
lepB; signal peptidase I [EC:3.4.21.89] -0.223 0.297 0.456 0.651
leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13] -0.100 1.127 0.930 0.976
leuB, IMDH; 3-isopropylmalate dehydrogenase [EC:1.1.1.85] -0.100 1.127 0.930 0.976
leuC, IPMI-L; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35] -0.100 1.127 0.930 0.976
leuD, IPMI-S; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35] -0.100 1.127 0.930 0.976
licD; lipopolysaccharide cholinephosphotransferase [EC:2.7.8.-] -0.176 0.308 0.568 0.695
lipA; lipoyl synthase [EC:2.8.1.8] -0.230 0.317 0.469 0.651
lldE; L-lactate dehydrogenase complex protein LldE -0.233 0.320 0.468 0.651
lldF; L-lactate dehydrogenase complex protein LldF -0.233 0.320 0.468 0.651
lldG; L-lactate dehydrogenase complex protein LldG -0.233 0.320 0.468 0.651
lolA; outer membrane lipoprotein carrier protein -0.750 0.852 0.380 0.651
lolC_E; lipoprotein-releasing system permease protein -0.230 0.296 0.438 0.651
lolD; lipoprotein-releasing system ATP-binding protein [EC:3.6.3.-] -0.230 0.296 0.438 0.651
lon; ATP-dependent Lon protease [EC:3.4.21.53] -0.220 0.308 0.477 0.651
lplA, lplJ; lipoate—protein ligase [EC:6.3.1.20] -0.717 0.722 0.322 0.651
lptB; lipopolysaccharide export system ATP-binding protein [EC:3.6.3.-] -0.230 0.296 0.438 0.651
lptF; lipopolysaccharide export system permease protein -0.230 0.296 0.438 0.651
lptG; lipopolysaccharide export system permease protein -0.230 0.296 0.438 0.651
lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129] -0.230 0.296 0.438 0.651
lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182] -0.230 0.296 0.438 0.651
lpxC-fabZ; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59] -0.230 0.296 0.438 0.651
lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191] -0.230 0.296 0.438 0.651
lpxH; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54] -0.230 0.296 0.438 0.651
lpxK; tetraacyldisaccharide 4’-kinase [EC:2.7.1.130] -0.230 0.296 0.438 0.651
lpxL, htrB; Kdo2-lipid IVA lauroyltransferase [EC:2.3.1.241] -0.230 0.296 0.438 0.651
lrp; Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein -0.042 0.347 0.904 0.976
lspA; signal peptidase II [EC:3.4.23.36] -0.230 0.296 0.438 0.651
ltaE; threonine aldolase [EC:4.1.2.48] -0.170 0.761 0.824 0.900
ltrA; RNA-directed DNA polymerase [EC:2.7.7.49] 2.304 1.989 0.248 0.651
luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21] -0.263 0.312 0.401 0.651
LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7] -0.230 0.296 0.438 0.651
lysA; diaminopimelate decarboxylase [EC:4.1.1.20] -0.274 0.307 0.374 0.651
lysC; aspartate kinase [EC:2.7.2.4] -0.230 0.296 0.438 0.651
maa; maltose O-acetyltransferase [EC:2.3.1.79] -0.230 0.328 0.484 0.651
maf; septum formation protein -0.230 0.296 0.438 0.651
mal; methylaspartate ammonia-lyase [EC:4.3.1.2] -0.221 0.572 0.699 0.797
malQ; 4-alpha-glucanotransferase [EC:2.4.1.25] -0.230 0.296 0.438 0.651
malY, malT; maltose/moltooligosaccharide transporter -0.228 0.293 0.436 0.651
malZ; alpha-glucosidase [EC:3.2.1.20] -0.117 0.305 0.702 0.797
MAN; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78] -0.189 0.299 0.528 0.663
manA, MPI; mannose-6-phosphate isomerase [EC:5.3.1.8] -0.230 0.296 0.438 0.651
manB; phosphomannomutase [EC:5.4.2.8] -0.230 0.296 0.438 0.651
manC, cpsB; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13] -0.230 0.296 0.438 0.651
map; methionyl aminopeptidase [EC:3.4.11.18] -0.224 0.289 0.440 0.651
marC; multiple antibiotic resistance protein -0.754 1.120 0.502 0.651
MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10] -0.230 0.296 0.438 0.651
mbtN, fadE14; acyl-ACP dehydrogenase [EC:1.3.99.-] -0.754 1.120 0.502 0.651
mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-] 0.358 0.550 0.516 0.651
mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC 0.358 0.550 0.516 0.651
mdh; malate dehydrogenase [EC:1.1.1.37] -0.230 0.296 0.438 0.651
menA; 1,4-dihydroxy-2-naphthoate octaprenyltransferase [EC:2.5.1.74 2.5.1.-] -0.230 0.296 0.438 0.651
menB; naphthoate synthase [EC:4.1.3.36] -0.230 0.296 0.438 0.651
menD; 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [EC:2.2.1.9] -0.230 0.296 0.438 0.651
menE; O-succinylbenzoic acid—CoA ligase [EC:6.2.1.26] -0.219 0.301 0.468 0.651
mepS, spr; murein DD-endopeptidase / murein LD-carboxypeptidase [EC:3.4.-.- 3.4.17.13] -0.754 1.120 0.502 0.651
metA; homoserine O-succinyltransferase/O-acetyltransferase [EC:2.3.1.46 2.3.1.31] -0.274 0.307 0.374 0.651
metF, MTHFR; methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] -0.264 0.307 0.391 0.651
metH, MTR; 5-methyltetrahydrofolate–homocysteine methyltransferase [EC:2.1.1.13] -0.206 0.312 0.510 0.651
metK; S-adenosylmethionine synthetase [EC:2.5.1.6] -0.243 0.292 0.407 0.651
metY; O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49] -0.208 0.306 0.498 0.651
mfd; transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-] -0.230 0.296 0.438 0.651
mgp; 4-O-beta-D-mannosyl-D-glucose phosphorylase [EC:2.4.1.281] -0.588 0.587 0.318 0.651
mgtC; putative Mg2+ transporter-C (MgtC) family protein -0.280 0.308 0.365 0.651
miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75] -0.230 0.296 0.438 0.651
miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3] -0.230 0.296 0.438 0.651
mlaD, linM; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein -0.230 0.296 0.438 0.651
mlaE, linK; phospholipid/cholesterol/gamma-HCH transport system permease protein -0.230 0.296 0.438 0.651
mlaF, linL, mkl; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein -0.230 0.296 0.438 0.651
mltD, dniR; membrane-bound lytic murein transglycosylase D [EC:4.2.2.-] -0.235 0.297 0.430 0.651
mltF; membrane-bound lytic murein transglycosylase F [EC:4.2.2.-] -0.468 0.400 0.244 0.651
MMAB, pduO; cob(I)alamin adenosyltransferase [EC:2.5.1.17] -0.263 0.312 0.401 0.651
mnmA, trmU; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13] -0.230 0.296 0.438 0.651
mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-] -0.230 0.296 0.438 0.651
mntH; manganese transport protein -0.224 0.319 0.483 0.651
moaA, CNX2; GTP 3’,8-cyclase [EC:4.1.99.22] -0.137 0.613 0.823 0.900
mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72] -0.171 0.451 0.705 0.799
modF; molybdate transport system ATP-binding protein 18.519 3411.091 0.996 0.998
motB; chemotaxis protein MotB -0.230 0.296 0.438 0.651
moxR; MoxR-like ATPase [EC:3.6.3.-] -0.170 0.284 0.551 0.683
mp2; beta-1,4-mannooligosaccharide/beta-1,4-mannosyl-N-acetylglucosamine phosphorylase [EC:2.4.1.319 2.4.1.320] -0.234 0.288 0.419 0.651
mraW, rsmH; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199] -0.230 0.296 0.438 0.651
mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] -0.230 0.296 0.438 0.651
mraZ; MraZ protein -0.262 0.309 0.398 0.651
mrcA; penicillin-binding protein 1A [EC:2.4.1.129 3.4.16.4] -0.230 0.296 0.438 0.651
mrdA; penicillin-binding protein 2 [EC:3.4.16.4] -0.194 0.303 0.523 0.657
mreB; rod shape-determining protein MreB and related proteins -0.230 0.296 0.438 0.651
mreC; rod shape-determining protein MreC -0.230 0.296 0.438 0.651
mrp, NUBPL; ATP-binding protein involved in chromosome partitioning -0.230 0.296 0.438 0.651
mrr; restriction system protein -0.301 0.567 0.596 0.722
msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:3.6.3.-] -0.230 0.296 0.438 0.651
mscL; large conductance mechanosensitive channel -0.230 0.296 0.438 0.651
mscS; small conductance mechanosensitive channel -0.754 1.120 0.502 0.651
msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12] -0.230 0.296 0.438 0.651
mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5] -0.230 0.296 0.438 0.651
MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9] -0.230 0.296 0.438 0.651
mtgA; monofunctional glycosyltransferase [EC:2.4.1.129] -0.230 0.296 0.438 0.651
MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2] -0.230 0.296 0.438 0.651
mtnN, mtn, pfs; adenosylhomocysteine nucleosidase [EC:3.2.2.9] -0.230 0.296 0.438 0.651
MuB; ATP-dependent target DNA activator [EC:3.6.1.3] -0.261 0.938 0.781 0.865
murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] -0.230 0.296 0.438 0.651
murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] -0.230 0.296 0.438 0.651
murC; UDP-N-acetylmuramate–alanine ligase [EC:6.3.2.8] -0.230 0.296 0.438 0.651
murD; UDP-N-acetylmuramoylalanine–D-glutamate ligase [EC:6.3.2.9] -0.230 0.296 0.438 0.651
murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase [EC:6.3.2.13] -0.230 0.296 0.438 0.651
murF; UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase [EC:6.3.2.10] -0.230 0.296 0.438 0.651
murG; UDP-N-acetylglucosamine–N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] -0.230 0.296 0.438 0.651
murI; glutamate racemase [EC:5.1.1.3] -0.230 0.296 0.438 0.651
murQ; N-acetylmuramic acid 6-phosphate etherase [EC:4.2.1.126] -0.747 0.519 0.152 0.651
mutL; DNA mismatch repair protein MutL -0.230 0.296 0.438 0.651
mutS; DNA mismatch repair protein MutS -0.230 0.296 0.438 0.651
mutS2; DNA mismatch repair protein MutS2 -0.230 0.296 0.438 0.651
mutT, NUDT15, MTH2; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] -0.128 0.324 0.693 0.797
mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] -0.230 0.296 0.438 0.651
mviM; virulence factor -0.262 0.328 0.427 0.651
mvpA, vapC; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-] 0.141 0.367 0.701 0.797
nadA; quinolinate synthase [EC:2.5.1.72] -0.172 0.328 0.602 0.723
nadB; L-aspartate oxidase [EC:1.4.3.16] -0.172 0.328 0.602 0.723
nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19] -0.172 0.328 0.602 0.723
nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18] -0.230 0.296 0.438 0.651
nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6] -0.226 0.290 0.438 0.651
NAGLU; alpha-N-acetylglucosaminidase [EC:3.2.1.50] -0.855 0.801 0.287 0.651
NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22] -0.230 0.296 0.438 0.651
ndh; NADH dehydrogenase [EC:1.6.99.3] -0.211 0.290 0.469 0.651
ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6] -0.754 1.120 0.502 0.651
NEU1; sialidase-1 [EC:3.2.1.18] -0.234 0.288 0.419 0.651
neuA; N-acylneuraminate cytidylyltransferase [EC:2.7.7.43] -2.232 1.933 0.250 0.651
nfrA2; FMN reductase [NAD(P)H] [EC:1.5.1.39] -0.230 0.296 0.438 0.651
nhaA; Na+:H+ antiporter, NhaA family -0.205 0.309 0.509 0.651
nhaC; Na+:H+ antiporter, NhaC family 18.519 3411.091 0.996 0.998
norB, norC; MFS transporter, DHA2 family, multidrug resistance protein 2.304 1.989 0.248 0.651
norB; nitric oxide reductase subunit B [EC:1.7.2.5] 0.054 0.493 0.913 0.976
nosD; nitrous oxidase accessory protein -0.319 0.983 0.746 0.834
nosF; Cu-processing system ATP-binding protein -0.319 0.983 0.746 0.834
nosL; copper chaperone NosL -0.319 0.983 0.746 0.834
nosY; Cu-processing system permease protein -0.319 0.983 0.746 0.834
nosZ; nitrous-oxide reductase [EC:1.7.2.4] -0.319 0.983 0.746 0.834
npdA; NAD-dependent deacetylase [EC:3.5.1.-] -0.263 0.312 0.401 0.651
nqrA; Na+-transporting NADH:ubiquinone oxidoreductase subunit A [EC:1.6.5.8] -0.230 0.296 0.438 0.651
nqrB; Na+-transporting NADH:ubiquinone oxidoreductase subunit B [EC:1.6.5.8] -0.230 0.296 0.438 0.651
nqrC; Na+-transporting NADH:ubiquinone oxidoreductase subunit C [EC:1.6.5.8] -0.230 0.296 0.438 0.651
nqrD; Na+-transporting NADH:ubiquinone oxidoreductase subunit D [EC:1.6.5.8] -0.230 0.296 0.438 0.651
nqrE; Na+-transporting NADH:ubiquinone oxidoreductase subunit E [EC:1.6.5.8] -0.230 0.296 0.438 0.651
nqrF; Na+-transporting NADH:ubiquinone oxidoreductase subunit F [EC:1.6.5.8] -0.230 0.296 0.438 0.651
nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4] -0.230 0.296 0.438 0.651
nrfA; nitrite reductase (cytochrome c-552) [EC:1.7.2.2] -0.217 0.299 0.469 0.651
nrfH; cytochrome c nitrite reductase small subunit -0.217 0.299 0.469 0.651
nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3] -0.230 0.296 0.438 0.651
nspC; carboxynorspermidine decarboxylase [EC:4.1.1.96] -0.230 0.296 0.438 0.651
NTH; endonuclease III [EC:4.2.99.18] -0.230 0.296 0.438 0.651
nuoA; NADH-quinone oxidoreductase subunit A [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoB; NADH-quinone oxidoreductase subunit B [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoCD; NADH-quinone oxidoreductase subunit C/D [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoH; NADH-quinone oxidoreductase subunit H [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoI; NADH-quinone oxidoreductase subunit I [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoJ; NADH-quinone oxidoreductase subunit J [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoK; NADH-quinone oxidoreductase subunit K [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoL; NADH-quinone oxidoreductase subunit L [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoM; NADH-quinone oxidoreductase subunit M [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoN; NADH-quinone oxidoreductase subunit N [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nupG; MFS transporter, NHS family, nucleoside permease -0.230 0.296 0.438 0.651
nusA; N utilization substance protein A -0.230 0.296 0.438 0.651
nusB; N utilization substance protein B -0.230 0.296 0.438 0.651
nusG; transcriptional antiterminator NusG -0.230 0.296 0.438 0.651
obgE, cgtA; GTPase [EC:3.6.5.-] -0.230 0.296 0.438 0.651
ogt, MGMT; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] -0.155 0.301 0.607 0.723
ompX; outer membrane protein X -0.096 0.328 0.770 0.853
oprO_P; phosphate-selective porin OprO and OprP -0.180 0.298 0.546 0.680
oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator -0.213 0.298 0.476 0.651
pabB; para-aminobenzoate synthetase component I [EC:2.6.1.85] -0.158 0.328 0.632 0.746
pabC; 4-amino-4-deoxychorismate lyase [EC:4.1.3.38] -0.158 0.328 0.632 0.746
padR; PadR family transcriptional regulator, regulatory protein PadR -1.243 1.127 0.272 0.651
panB; 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11] -0.213 0.298 0.477 0.651
panC; pantoate–beta-alanine ligase [EC:6.3.2.1] -0.213 0.298 0.477 0.651
panD; aspartate 1-decarboxylase [EC:4.1.1.11] -0.213 0.298 0.477 0.651
panE, apbA; 2-dehydropantoate 2-reductase [EC:1.1.1.169] -0.220 0.329 0.504 0.651
parA, soj; chromosome partitioning protein -0.290 0.310 0.351 0.651
parB, spo0J; chromosome partitioning protein, ParB family -0.230 0.296 0.438 0.651
parC; topoisomerase IV subunit A [EC:5.99.1.-] -0.230 0.296 0.438 0.651
parE; topoisomerase IV subunit B [EC:5.99.1.-] -0.230 0.296 0.438 0.651
PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15] -0.230 0.296 0.438 0.651
patB, malY; cystathione beta-lyase [EC:4.4.1.8] -0.267 0.319 0.403 0.651
pbuG; putative MFS transporter, AGZA family, xanthine/uracil permease -0.219 0.301 0.468 0.651
pcaC; 4-carboxymuconolactone decarboxylase [EC:4.1.1.44] -0.135 0.612 0.825 0.900
pcnB; poly(A) polymerase [EC:2.7.7.19] -0.754 1.120 0.502 0.651
PCYT1; choline-phosphate cytidylyltransferase [EC:2.7.7.15] -0.221 0.572 0.699 0.797
PDF, def; peptide deformylase [EC:3.5.1.88] -0.230 0.296 0.438 0.651
pdxA; 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262] -0.230 0.296 0.438 0.651
pdxB; erythronate-4-phosphate dehydrogenase [EC:1.1.1.290] -0.754 1.120 0.502 0.651
pdxJ; pyridoxine 5-phosphate synthase [EC:2.6.99.2] -0.754 1.120 0.502 0.651
pdxK, pdxY; pyridoxine kinase [EC:2.7.1.35] -0.186 0.306 0.545 0.680
pdxS, pdx1; pyridoxal 5’-phosphate synthase pdxS subunit [EC:4.3.3.6] -0.219 0.301 0.468 0.651
pdxT, pdx2; 5’-phosphate synthase pdxT subunit [EC:4.3.3.6] -0.219 0.301 0.468 0.651
penP; beta-lactamase class A [EC:3.5.2.6] -0.298 0.574 0.604 0.723
pepD; dipeptidase D [EC:3.4.13.-] -0.230 0.296 0.438 0.651
pepE; dipeptidase E [EC:3.4.13.21] -0.619 0.514 0.230 0.651
pepO; putative endopeptidase [EC:3.4.24.-] -0.192 0.304 0.529 0.663
pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9] -0.233 0.297 0.434 0.651
pepT; tripeptide aminopeptidase [EC:3.4.11.4] -0.230 0.296 0.438 0.651
perR; Fur family transcriptional regulator, peroxide stress response regulator -0.190 0.321 0.555 0.683
pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11] -0.230 0.296 0.438 0.651
pflA, pflC, pflE; pyruvate formate lyase activating enzyme [EC:1.97.1.4] -0.188 0.302 0.535 0.670
pfp, PFP; diphosphate-dependent phosphofructokinase [EC:2.7.1.90] -0.230 0.296 0.438 0.651
PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] 0.038 0.480 0.937 0.977
PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3] -0.230 0.296 0.438 0.651
pgm; phosphoglucomutase [EC:5.4.2.2] -0.230 0.296 0.438 0.651
pgpA; phosphatidylglycerophosphatase A [EC:3.1.3.27] -0.015 0.569 0.979 0.998
pgsA, PGS1; CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5] -0.227 0.517 0.662 0.775
pheA2; prephenate dehydratase [EC:4.2.1.51] -0.644 0.452 0.157 0.651
phnP; phosphoribosyl 1,2-cyclic phosphate phosphodiesterase [EC:3.1.4.55] -0.230 0.296 0.438 0.651
phoH, phoL; phosphate starvation-inducible protein PhoH and related proteins -0.230 0.296 0.438 0.651
phoN; acid phosphatase (class A) [EC:3.1.3.2] -0.073 0.305 0.811 0.894
phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] -0.230 0.296 0.438 0.651
pip; proline iminopeptidase [EC:3.4.11.5] 18.519 3411.091 0.996 0.998
PK, pyk; pyruvate kinase [EC:2.7.1.40] -0.230 0.296 0.438 0.651
plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] -0.230 0.296 0.438 0.651
pnbA; para-nitrobenzyl esterase [EC:3.1.1.-] -0.508 0.875 0.562 0.689
PNC1; nicotinamidase [EC:3.5.1.19] 0.358 0.550 0.516 0.651
pncA; nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-] -0.097 0.315 0.757 0.843
pncB, NAPRT1; nicotinate phosphoribosyltransferase [EC:6.3.4.21] -0.231 0.296 0.438 0.651
pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42] -0.230 0.296 0.438 0.651
pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] -0.230 0.296 0.438 0.651
pnuC; nicotinamide mononucleotide transporter -0.230 0.296 0.438 0.651
polA; DNA polymerase I [EC:2.7.7.7] -0.230 0.296 0.438 0.651
por, nifJ; pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-] -0.230 0.296 0.438 0.651
ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1] -0.230 0.296 0.438 0.651
PPIB, ppiB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8] -0.146 0.307 0.634 0.747
ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8] -0.230 0.296 0.438 0.651
ppnK, NADK; NAD+ kinase [EC:2.7.1.23] -0.230 0.296 0.438 0.651
ppnN; pyrimidine/purine-5’-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-] -0.274 0.310 0.377 0.651
PPOX, hemY; protoporphyrinogen/coproporphyrinogen III oxidase [EC:1.3.3.4 1.3.3.15] -0.232 0.293 0.430 0.651
pqqL; zinc protease [EC:3.4.24.-] -0.201 0.306 0.512 0.651
PRDX2_4, ahpC; peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC:1.11.1.15] -0.231 0.296 0.438 0.651
PREP; prolyl oligopeptidase [EC:3.4.21.26] -0.210 0.327 0.521 0.656
prfA, MTRF1, MRF1; peptide chain release factor 1 -0.230 0.296 0.438 0.651
prfB; peptide chain release factor 2 -0.230 0.296 0.438 0.651
prfC; peptide chain release factor 3 -0.230 0.296 0.438 0.651
priA; primosomal protein N’ (replication factor Y) (superfamily II helicase) [EC:3.6.4.-] -0.230 0.296 0.438 0.651
prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-] -0.230 0.296 0.438 0.651
proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41] 18.519 3411.091 0.996 0.998
proB; glutamate 5-kinase [EC:2.7.2.11] 18.519 3411.091 0.996 0.998
proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2] 0.139 1.250 0.912 0.976
PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] -0.230 0.296 0.438 0.651
psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65] -0.230 0.296 0.438 0.651
pspC; phage shock protein C -0.429 0.536 0.424 0.651
pstS; phosphate transport system substrate-binding protein -0.230 0.296 0.438 0.651
ptb; phosphate butyryltransferase [EC:2.3.1.19] -0.147 0.329 0.655 0.768
PTH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29] -0.230 0.296 0.438 0.651
PTS-Gat-EIIC, gatC, sgcC; PTS system, galactitol-specific IIC component -0.676 0.652 0.302 0.651
pulA; pullulanase [EC:3.2.1.41] -0.252 0.318 0.429 0.651
punA, PNP; purine-nucleoside phosphorylase [EC:2.4.2.1] -0.230 0.296 0.438 0.651
purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4] -0.230 0.296 0.438 0.651
purB, ADSL; adenylosuccinate lyase [EC:4.3.2.2] -0.230 0.296 0.438 0.651
purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6] -0.230 0.296 0.438 0.651
purD; phosphoribosylamine—glycine ligase [EC:6.3.4.13] -0.230 0.296 0.438 0.651
purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18] -0.230 0.296 0.438 0.651
purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14] -0.219 0.308 0.477 0.651
purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] -0.230 0.296 0.438 0.651
purL, PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3] -0.220 0.308 0.477 0.651
purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1] -0.230 0.296 0.438 0.651
purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] -0.360 0.503 0.475 0.651
purT; phosphoribosylglycinamide formyltransferase 2 [EC:2.1.2.2] -0.193 0.294 0.513 0.651
purU; formyltetrahydrofolate deformylase [EC:3.5.1.10] -0.789 0.881 0.372 0.651
pycB; pyruvate carboxylase subunit B [EC:6.4.1.1] -0.230 0.296 0.438 0.651
PYG, glgP; glycogen phosphorylase [EC:2.4.1.1] -0.230 0.296 0.438 0.651
pyrB, PYR2; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2] -0.230 0.296 0.438 0.651
pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14] -0.230 0.296 0.438 0.651
pyrDII; dihydroorotate dehydrogenase electron transfer subunit -0.230 0.296 0.438 0.651
pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10] -0.230 0.296 0.438 0.651
pyrF; orotidine-5’-phosphate decarboxylase [EC:4.1.1.23] -0.230 0.296 0.438 0.651
pyrG, CTPS; CTP synthase [EC:6.3.4.2] -0.230 0.296 0.438 0.651
pyrH; uridylate kinase [EC:2.7.4.22] -0.230 0.296 0.438 0.651
pyrI; aspartate carbamoyltransferase regulatory subunit -0.230 0.296 0.438 0.651
pyrP, uraA; uracil permease -0.217 0.297 0.467 0.651
QARS, glnS; glutaminyl-tRNA synthetase [EC:6.1.1.18] -0.230 0.296 0.438 0.651
queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17] -0.225 0.301 0.457 0.651
queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20] -0.230 0.296 0.438 0.651
queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50] -0.395 0.451 0.383 0.651
queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13] -0.230 0.296 0.438 0.651
queG; epoxyqueuosine reductase [EC:1.17.99.6] -0.230 0.296 0.438 0.651
radA, sms; DNA repair protein RadA/Sms -0.284 0.308 0.358 0.651
radC; DNA repair protein RadC -0.230 0.296 0.438 0.651
ramA; alpha-L-rhamnosidase [EC:3.2.1.40] -0.319 0.983 0.746 0.834
RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19] -0.230 0.296 0.438 0.651
raxB, cvaB; ATP-binding cassette, subfamily B, bacterial RaxB 2.304 1.989 0.248 0.651
rbfA; ribosome-binding factor A -0.230 0.296 0.438 0.651
rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66] -0.230 0.296 0.438 0.651
recA; recombination protein RecA -0.230 0.296 0.438 0.651
recF; DNA replication and repair protein RecF -0.230 0.296 0.438 0.651
recG; ATP-dependent DNA helicase RecG [EC:3.6.4.12] -0.213 0.312 0.495 0.651
recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] -0.230 0.296 0.438 0.651
recN; DNA repair protein RecN (Recombination protein N) -0.230 0.296 0.438 0.651
recO; DNA repair protein RecO (recombination protein O) -0.230 0.296 0.438 0.651
recQ; ATP-dependent DNA helicase RecQ [EC:3.6.4.12] -0.243 0.293 0.409 0.651
recR; recombination protein RecR -0.230 0.296 0.438 0.651
recX; regulatory protein -0.230 0.296 0.438 0.651
relA; GTP pyrophosphokinase [EC:2.7.6.5] -0.231 0.299 0.439 0.651
RENBP; N-acylglucosamine 2-epimerase [EC:5.1.3.8] -0.240 0.289 0.409 0.651
res; type III restriction enzyme [EC:3.1.21.5] -5.080 10.935 0.643 0.756
RETSAT; all-trans-retinol 13,14-reductase [EC:1.3.99.23] -0.696 0.523 0.185 0.651
rfbC, rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] -0.230 0.296 0.438 0.651
rfbD, rmlD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] -0.230 0.296 0.438 0.651
rgpA_B; gingipain R [EC:3.4.22.37] -0.001 1.049 0.999 0.999
rgpB; rhamnosyltransferase [EC:2.4.1.-] 0.358 0.550 0.516 0.651
rhaA; L-rhamnose isomerase [EC:5.3.1.14] -0.810 0.830 0.330 0.651
rhaB; rhamnulokinase [EC:2.7.1.5] -0.810 0.830 0.330 0.651
rhaD; rhamnulose-1-phosphate aldolase [EC:4.1.2.19] -0.810 0.830 0.330 0.651
rhaM; L-rhamnose mutarotase [EC:5.1.3.32] -0.846 0.965 0.382 0.651
rhaT; L-rhamnose-H+ transport protein -0.789 0.881 0.372 0.651
rho; transcription termination factor Rho -0.230 0.296 0.438 0.651
ribB, RIB3; 3,4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12] 2.304 1.989 0.248 0.651
ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25] -0.231 0.296 0.437 0.651
ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193] -0.230 0.296 0.438 0.651
ribE, RIB5; riboflavin synthase [EC:2.5.1.9] -0.230 0.296 0.438 0.651
ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2] -0.230 0.296 0.438 0.651
ribH, RIB4; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78] -0.230 0.296 0.438 0.651
ridA, tdcF, RIDA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10] -0.230 0.296 0.438 0.651
rimM; 16S rRNA processing protein RimM -0.230 0.296 0.438 0.651
rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4] -0.230 0.296 0.438 0.651
rimP; ribosome maturation factor RimP -0.230 0.296 0.438 0.651
rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177] -0.230 0.296 0.438 0.651
rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191] -0.230 0.296 0.438 0.651
rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192] -0.230 0.296 0.438 0.651
rlpA; rare lipoprotein A -0.217 0.299 0.469 0.651
rluA; tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29] -0.223 0.336 0.508 0.651
rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22] -0.230 0.296 0.438 0.651
rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] -0.230 0.296 0.438 0.651
rmuC; DNA recombination protein RmuC -0.230 0.296 0.438 0.651
rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3] -0.217 0.299 0.469 0.651
rnfA; electron transport complex protein RnfA 18.519 3411.091 0.996 0.998
rnfC; electron transport complex protein RnfC 18.519 3411.091 0.996 0.998
rnfD; electron transport complex protein RnfD 18.519 3411.091 0.996 0.998
rnfE; electron transport complex protein RnfE 18.519 3411.091 0.996 0.998
rnfG; electron transport complex protein RnfG -0.222 0.324 0.494 0.651
rng, cafA; ribonuclease G [EC:3.1.26.-] -0.230 0.296 0.438 0.651
rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4] -0.230 0.296 0.438 0.651
rnhB; ribonuclease HII [EC:3.1.26.4] -0.230 0.296 0.438 0.651
rnj; ribonuclease J [EC:3.1.-.-] -0.319 0.983 0.746 0.834
rnpA; ribonuclease P protein component [EC:3.1.26.5] -0.230 0.296 0.438 0.651
rnr, vacB; ribonuclease R [EC:3.1.-.-] -0.230 0.296 0.438 0.651
rny; ribonucrease Y [EC:3.1.-.-] -0.230 0.296 0.438 0.651
rnz; ribonuclease Z [EC:3.1.26.11] -0.230 0.296 0.438 0.651
rodA, mrdB; rod shape determining protein RodA -0.230 0.296 0.438 0.651
RP-L1, MRPL1, rplA; large subunit ribosomal protein L1 -0.230 0.296 0.438 0.651
RP-L10, MRPL10, rplJ; large subunit ribosomal protein L10 -0.230 0.296 0.438 0.651
RP-L11, MRPL11, rplK; large subunit ribosomal protein L11 -0.230 0.296 0.438 0.651
RP-L13, MRPL13, rplM; large subunit ribosomal protein L13 -0.230 0.296 0.438 0.651
RP-L14, MRPL14, rplN; large subunit ribosomal protein L14 -0.230 0.296 0.438 0.651
RP-L15, MRPL15, rplO; large subunit ribosomal protein L15 -0.230 0.296 0.438 0.651
RP-L16, MRPL16, rplP; large subunit ribosomal protein L16 -0.230 0.296 0.438 0.651
RP-L17, MRPL17, rplQ; large subunit ribosomal protein L17 -0.201 0.284 0.481 0.651
RP-L18, MRPL18, rplR; large subunit ribosomal protein L18 -0.230 0.296 0.438 0.651
RP-L19, MRPL19, rplS; large subunit ribosomal protein L19 -0.230 0.296 0.438 0.651
RP-L2, MRPL2, rplB; large subunit ribosomal protein L2 -0.230 0.296 0.438 0.651
RP-L20, MRPL20, rplT; large subunit ribosomal protein L20 -0.230 0.296 0.438 0.651
RP-L21, MRPL21, rplU; large subunit ribosomal protein L21 -0.230 0.296 0.438 0.651
RP-L22, MRPL22, rplV; large subunit ribosomal protein L22 -0.230 0.296 0.438 0.651
RP-L23, MRPL23, rplW; large subunit ribosomal protein L23 -0.230 0.296 0.438 0.651
RP-L24, MRPL24, rplX; large subunit ribosomal protein L24 -0.230 0.296 0.438 0.651
RP-L25, rplY; large subunit ribosomal protein L25 -0.230 0.296 0.438 0.651
RP-L27, MRPL27, rpmA; large subunit ribosomal protein L27 -0.230 0.296 0.438 0.651
RP-L28, MRPL28, rpmB; large subunit ribosomal protein L28 -0.230 0.296 0.438 0.651
RP-L29, rpmC; large subunit ribosomal protein L29 -0.230 0.296 0.438 0.651
RP-L3, MRPL3, rplC; large subunit ribosomal protein L3 -0.230 0.296 0.438 0.651
RP-L30, MRPL30, rpmD; large subunit ribosomal protein L30 -0.230 0.296 0.438 0.651
RP-L31, rpmE; large subunit ribosomal protein L31 -0.230 0.296 0.438 0.651
RP-L32, MRPL32, rpmF; large subunit ribosomal protein L32 -0.230 0.296 0.438 0.651
RP-L33, MRPL33, rpmG; large subunit ribosomal protein L33 -0.230 0.296 0.438 0.651
RP-L34, MRPL34, rpmH; large subunit ribosomal protein L34 -0.228 0.293 0.436 0.651
RP-L35, MRPL35, rpmI; large subunit ribosomal protein L35 -0.230 0.296 0.438 0.651
RP-L36, MRPL36, rpmJ; large subunit ribosomal protein L36 -0.123 0.303 0.685 0.796
RP-L4, MRPL4, rplD; large subunit ribosomal protein L4 -0.230 0.296 0.438 0.651
RP-L5, MRPL5, rplE; large subunit ribosomal protein L5 -0.230 0.296 0.438 0.651
RP-L6, MRPL6, rplF; large subunit ribosomal protein L6 -0.230 0.296 0.438 0.651
RP-L7, MRPL12, rplL; large subunit ribosomal protein L7/L12 -0.230 0.296 0.438 0.651
RP-L9, MRPL9, rplI; large subunit ribosomal protein L9 -0.230 0.296 0.438 0.651
RP-S1, rpsA; small subunit ribosomal protein S1 -0.230 0.296 0.438 0.651
RP-S10, MRPS10, rpsJ; small subunit ribosomal protein S10 -0.230 0.296 0.438 0.651
RP-S11, MRPS11, rpsK; small subunit ribosomal protein S11 -0.230 0.296 0.438 0.651
RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12 -0.230 0.296 0.438 0.651
RP-S13, rpsM; small subunit ribosomal protein S13 -0.230 0.296 0.438 0.651
RP-S14, MRPS14, rpsN; small subunit ribosomal protein S14 -0.230 0.296 0.438 0.651
RP-S15, MRPS15, rpsO; small subunit ribosomal protein S15 -0.230 0.296 0.438 0.651
RP-S16, MRPS16, rpsP; small subunit ribosomal protein S16 -0.230 0.296 0.438 0.651
RP-S17, MRPS17, rpsQ; small subunit ribosomal protein S17 -0.230 0.296 0.438 0.651
RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18 -0.230 0.296 0.438 0.651
RP-S19, rpsS; small subunit ribosomal protein S19 -0.230 0.296 0.438 0.651
RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2 -0.230 0.296 0.438 0.651
RP-S20, rpsT; small subunit ribosomal protein S20 -0.230 0.296 0.438 0.651
RP-S21, MRPS21, rpsU; small subunit ribosomal protein S21 -0.230 0.296 0.438 0.651
RP-S3, rpsC; small subunit ribosomal protein S3 -0.230 0.296 0.438 0.651
RP-S4, rpsD; small subunit ribosomal protein S4 -0.230 0.296 0.438 0.651
RP-S5, MRPS5, rpsE; small subunit ribosomal protein S5 -0.230 0.296 0.438 0.651
RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6 -0.230 0.296 0.438 0.651
RP-S7, MRPS7, rpsG; small subunit ribosomal protein S7 -0.230 0.296 0.438 0.651
RP-S8, rpsH; small subunit ribosomal protein S8 -0.230 0.296 0.438 0.651
RP-S9, MRPS9, rpsI; small subunit ribosomal protein S9 -0.230 0.296 0.438 0.651
rpe, RPE; ribulose-phosphate 3-epimerase [EC:5.1.3.1] -0.230 0.296 0.438 0.651
rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6] -0.230 0.296 0.438 0.651
rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] -0.220 0.308 0.477 0.651
rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] -0.230 0.296 0.438 0.651
rpoC; DNA-directed RNA polymerase subunit beta’ [EC:2.7.7.6] -0.230 0.296 0.438 0.651
rpoD; RNA polymerase primary sigma factor -0.226 0.304 0.458 0.651
rpoE; RNA polymerase sigma-70 factor, ECF subfamily -0.274 0.308 0.375 0.651
rpoN; RNA polymerase sigma-54 factor -0.230 0.296 0.438 0.651
rseC; sigma-E factor negative regulatory protein RseC 18.519 3411.091 0.996 0.998
rseP; regulator of sigma E protease [EC:3.4.24.-] -0.230 0.296 0.438 0.651
rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] -0.230 0.296 0.438 0.651
rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193] -0.230 0.296 0.438 0.651
rsmI; 16S rRNA (cytidine1402-2’-O)-methyltransferase [EC:2.1.1.198] -0.242 0.294 0.412 0.651
RTCB, rtcB; tRNA-splicing ligase RtcB (3’-phosphate/5’-hydroxy nucleic acid ligase) [EC:6.5.1.8] -2.232 1.933 0.250 0.651
rtpR; ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2] -0.230 0.296 0.438 0.651
rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190] -0.230 0.296 0.438 0.651
ruvA; holliday junction DNA helicase RuvA [EC:3.6.4.12] -0.230 0.296 0.438 0.651
ruvB; holliday junction DNA helicase RuvB [EC:3.6.4.12] -0.230 0.296 0.438 0.651
ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4] -0.230 0.296 0.438 0.651
ruvX; putative holliday junction resolvase [EC:3.1.-.-] -0.230 0.296 0.438 0.651
sacC, levB; levanase [EC:3.2.1.65] -0.223 0.321 0.489 0.651
SAM50, TOB55, bamA; outer membrane protein insertion porin family -0.230 0.296 0.438 0.651
sanA; SanA protein -0.089 0.344 0.796 0.879
SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11] -0.230 0.296 0.438 0.651
sbcD, mre11; DNA repair protein SbcD/Mre11 -0.746 1.115 0.505 0.651
sdhA, frdA; succinate dehydrogenase / fumarate reductase, flavoprotein subunit [EC:1.3.5.1 1.3.5.4] -0.230 0.296 0.438 0.651
sdhB, frdB; succinate dehydrogenase / fumarate reductase, iron-sulfur subunit [EC:1.3.5.1 1.3.5.4] -0.230 0.296 0.438 0.651
sdhC, frdC; succinate dehydrogenase / fumarate reductase, cytochrome b subunit -0.230 0.296 0.438 0.651
secA; preprotein translocase subunit SecA -0.230 0.296 0.438 0.651
secDF; SecD/SecF fusion protein -0.230 0.296 0.438 0.651
secE; preprotein translocase subunit SecE -0.216 0.300 0.472 0.651
secG; preprotein translocase subunit SecG -0.230 0.296 0.438 0.651
secY; preprotein translocase subunit SecY -0.230 0.296 0.438 0.651
serA, PHGDH; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] -0.228 0.293 0.436 0.651
serB, PSPH; phosphoserine phosphatase [EC:3.1.3.3] -0.237 0.319 0.459 0.651
serC, PSAT1; phosphoserine aminotransferase [EC:2.6.1.52] -0.228 0.293 0.436 0.651
SERPINB; serpin B -0.131 0.338 0.699 0.797
SIAE; sialate O-acetylesterase [EC:3.1.1.53] -0.283 0.313 0.368 0.651
SLC13A2_3_5; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 -0.208 0.313 0.507 0.651
slo; thiol-activated cytolysin -0.154 0.385 0.690 0.797
slyD; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8] -0.230 0.296 0.438 0.651
smf; DNA processing protein -0.230 0.296 0.438 0.651
smpB; SsrA-binding protein -0.230 0.296 0.438 0.651
SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1] -0.396 0.395 0.317 0.651
speA; arginine decarboxylase [EC:4.1.1.19] -0.230 0.296 0.438 0.651
speG, SAT; diamine N-acetyltransferase [EC:2.3.1.57] -0.230 0.296 0.438 0.651
spoU; RNA methyltransferase, TrmH family -0.230 0.296 0.438 0.651
SPP; sucrose-6-phosphatase [EC:3.1.3.24] -0.208 0.288 0.471 0.651
sppA; protease IV [EC:3.4.21.-] -0.230 0.296 0.438 0.651
spsF; spore coat polysaccharide biosynthesis protein SpsF -0.319 0.983 0.746 0.834
SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4] -0.230 0.296 0.438 0.651
ssb; single-strand DNA-binding protein -0.232 0.301 0.441 0.651
sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5] -0.173 0.329 0.600 0.723
sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5] -0.173 0.329 0.600 0.723
sufB; Fe-S cluster assembly protein SufB -0.230 0.296 0.438 0.651
sufC; Fe-S cluster assembly ATP-binding protein -0.230 0.296 0.438 0.651
sufD; Fe-S cluster assembly protein SufD -0.230 0.296 0.438 0.651
sufE; cysteine desulfuration protein SufE -0.230 0.296 0.438 0.651
sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16] -0.230 0.296 0.438 0.651
surA; peptidyl-prolyl cis-trans isomerase SurA [EC:5.2.1.8] -0.230 0.296 0.438 0.651
surE; 5’-nucleotidase [EC:3.1.3.5] -0.230 0.296 0.438 0.651
tadA; tRNA(adenine34) deaminase [EC:3.5.4.33] -0.230 0.296 0.438 0.651
tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] -0.227 0.333 0.497 0.651
tagD; glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39] 0.358 0.550 0.516 0.651
tagF; CDP-glycerol glycerophosphotransferase [EC:2.7.8.12] 0.092 1.404 0.948 0.986
TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3] -0.230 0.296 0.438 0.651
tatA; sec-independent protein translocase protein TatA -0.520 0.870 0.551 0.683
tatC; sec-independent protein translocase protein TatC -0.520 0.870 0.551 0.683
tatD; TatD DNase family protein [EC:3.1.21.-] -0.234 0.283 0.408 0.651
TC.AGCS; alanine or glycine:cation symporter, AGCS family -0.045 0.351 0.898 0.972
TC.BASS; bile acid:Na+ symporter, BASS family -0.228 0.293 0.437 0.651
TC.CIC; chloride channel protein, CIC family -0.230 0.296 0.438 0.651
TC.CPA1; monovalent cation:H+ antiporter, CPA1 family -2.232 1.933 0.250 0.651
TC.FEV.OM; iron complex outermembrane recepter protein -0.224 0.298 0.453 0.651
TC.FEV.OM2, cirA, cfrA, hmuR; outer membrane receptor for ferrienterochelin and colicins -0.212 0.308 0.491 0.651
TC.FEV.OM3, tbpA, hemR, lbpA, hpuB, bhuR, hugA, hmbR; hemoglobin/transferrin/lactoferrin receptor protein 0.054 0.493 0.913 0.976
TC.GPH; glycoside/pentoside/hexuronide:cation symporter, GPH family -0.606 0.561 0.282 0.651
TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family -0.216 0.278 0.438 0.651
TC.KEF; monovalent cation:H+ antiporter-2, CPA2 family -0.187 0.310 0.548 0.681
TC.MATE, SLC47A, norM, mdtK, dinF; multidrug resistance protein, MATE family -0.227 0.307 0.462 0.651
TC.NSS; neurotransmitter:Na+ symporter, NSS family -0.242 0.316 0.446 0.651
TC.PIT; inorganic phosphate transporter, PiT family 2.304 1.989 0.248 0.651
TC.POT; proton-dependent oligopeptide transporter, POT family -0.230 0.296 0.438 0.651
TC.SSS; solute:Na+ symporter, SSS family -0.692 0.616 0.263 0.651
TC.SULP; sulfate permease, SulP family -0.746 1.115 0.505 0.651
TC.ZIP, zupT, ZRT3, ZIP2; zinc transporter, ZIP family -0.247 0.568 0.664 0.776
tdk, TK; thymidine kinase [EC:2.7.1.21] -0.230 0.296 0.438 0.651
terC; tellurite resistance protein TerC -0.625 0.575 0.278 0.651
tetM, tetO; ribosomal protection tetracycline resistance protein -0.388 0.498 0.437 0.651
tex; protein Tex -0.196 0.300 0.514 0.651
tgt, QTRT1; queuine tRNA-ribosyltransferase [EC:2.4.2.29] -0.230 0.296 0.438 0.651
THI4, THI1; cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60] 0.014 0.383 0.970 0.998
thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17] 0.014 0.383 0.970 0.998
thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7] -0.134 0.312 0.669 0.779
thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3] -0.063 0.337 0.853 0.928
thiG; thiazole synthase [EC:2.8.1.10] 18.519 3411.091 0.996 0.998
thiH; 2-iminoacetate synthase [EC:4.1.99.19] 18.519 3411.091 0.996 0.998
thiJ; protein deglycase [EC:3.5.1.124] -0.230 0.296 0.438 0.651
thiL; thiamine-monophosphate kinase [EC:2.7.4.16] -0.230 0.296 0.438 0.651
thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2] -0.198 0.307 0.519 0.653
thiS; sulfur carrier protein 18.519 3411.091 0.996 0.998
thrA; bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3] -0.274 0.307 0.374 0.651
thrC; threonine synthase [EC:4.2.3.1] -0.606 0.561 0.282 0.651
thyA, TYMS; thymidylate synthase [EC:2.1.1.45] -0.172 0.309 0.579 0.705
thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148] -0.625 0.575 0.278 0.651
tig; trigger factor -0.230 0.296 0.438 0.651
tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19] -0.230 0.296 0.438 0.651
tnaA; tryptophanase [EC:4.1.99.1] -0.221 0.572 0.699 0.797
tolA; colicin import membrane protein -0.164 0.315 0.604 0.723
tolC; outer membrane protein -0.590 0.508 0.248 0.651
tonB; periplasmic protein TonB -0.185 0.276 0.505 0.651
topA; DNA topoisomerase I [EC:5.99.1.2] -0.230 0.296 0.438 0.651
topB; DNA topoisomerase III [EC:5.99.1.2] -0.314 0.345 0.363 0.651
TPI, tpiA; triosephosphate isomerase (TIM) [EC:5.3.1.1] -0.240 0.307 0.435 0.651
tpx; thiol peroxidase, atypical 2-Cys peroxiredoxin [EC:1.11.1.15] -0.754 1.120 0.502 0.651
treS; maltose alpha-D-glucosyltransferase / alpha-amylase [EC:5.4.99.16 3.2.1.1] -0.629 0.781 0.422 0.651
trkA, ktrA; trk system potassium uptake protein -0.230 0.296 0.438 0.651
trkH, trkG, ktrB; trk system potassium uptake protein -0.230 0.296 0.438 0.651
trmB, METTL1; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33] -0.230 0.296 0.438 0.651
trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228] -0.230 0.296 0.438 0.651
troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator 0.038 0.480 0.937 0.977
trpA; tryptophan synthase alpha chain [EC:4.2.1.20] -0.089 1.133 0.938 0.977
trpB; tryptophan synthase beta chain [EC:4.2.1.20] -0.229 0.301 0.447 0.651
trpC; indole-3-glycerol phosphate synthase [EC:4.1.1.48] -0.376 0.442 0.397 0.651
trpD; anthranilate phosphoribosyltransferase [EC:2.4.2.18] -0.089 1.133 0.938 0.977
trpE; anthranilate synthase component I [EC:4.1.3.27] -0.089 1.133 0.938 0.977
trpF; phosphoribosylanthranilate isomerase [EC:5.3.1.24] -0.219 0.301 0.468 0.651
trpG; anthranilate synthase component II [EC:4.1.3.27] -0.167 0.324 0.608 0.725
truA, PUS1; tRNA pseudouridine38-40 synthase [EC:5.4.99.12] -0.230 0.296 0.438 0.651
truB, PUS4, TRUB1; tRNA pseudouridine55 synthase [EC:5.4.99.25] -0.230 0.296 0.438 0.651
trxA; thioredoxin 1 -0.230 0.296 0.438 0.651
trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9] -0.230 0.296 0.438 0.651
tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB -0.230 0.296 0.438 0.651
tsaC, rimN, SUA5; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87] -0.230 0.296 0.438 0.651
tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE -0.230 0.296 0.438 0.651
tsf, TSFM; elongation factor Ts -0.230 0.296 0.438 0.651
TSTA3, fcl; GDP-L-fucose synthase [EC:1.1.1.271] -0.230 0.296 0.438 0.651
tuf, TUFM; elongation factor Tu -0.230 0.296 0.438 0.651
typA, bipA; GTP-binding protein -0.230 0.296 0.438 0.651
ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201] -0.230 0.296 0.438 0.651
udk, UCK; uridine kinase [EC:2.7.1.48] -0.230 0.296 0.438 0.651
udp, UPP; uridine phosphorylase [EC:2.4.2.3] -0.230 0.296 0.438 0.651
UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22] -0.219 0.308 0.477 0.651
umuC; DNA polymerase V -0.183 0.301 0.543 0.678
umuD; DNA polymerase V [EC:3.4.21.-] -2.933 2.379 0.219 0.651
UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27] -0.204 0.307 0.507 0.651
upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9] -0.230 0.296 0.438 0.651
uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] -0.230 0.296 0.438 0.651
URA4, pyrC; dihydroorotase [EC:3.5.2.3] -0.220 0.308 0.477 0.651
utp; urea transporter -17.599 3454.822 0.996 0.998
uup; ABC transport system ATP-binding/permease protein -0.220 0.308 0.477 0.651
uvrA; excinuclease ABC subunit A -0.215 0.290 0.459 0.651
uvrB; excinuclease ABC subunit B -0.230 0.296 0.438 0.651
uvrC; excinuclease ABC subunit C -0.230 0.296 0.438 0.651
uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12] -0.254 0.306 0.407 0.651
uxaA; altronate hydrolase [EC:4.2.1.7] -0.676 0.652 0.302 0.651
uxaB; tagaturonate reductase [EC:1.1.1.58] -0.676 0.652 0.302 0.651
uxaC; glucuronate isomerase [EC:5.3.1.12] -0.839 0.582 0.151 0.651
UXS1, uxs; UDP-glucuronate decarboxylase [EC:4.1.1.35] -0.137 0.613 0.823 0.900
uxuA; mannonate dehydratase [EC:4.2.1.8] -0.692 0.616 0.263 0.651
uxuB; fructuronate reductase [EC:1.1.1.57] -0.677 0.652 0.301 0.651
vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22] -0.199 0.288 0.490 0.651
VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9] -0.230 0.296 0.438 0.651
vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-] -0.298 0.485 0.540 0.676
WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] -0.230 0.296 0.438 0.651
wbpO; UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.-] -0.076 0.332 0.819 0.899
wcaJ; putative colanic acid biosysnthesis UDP-glucose lipid carrier transferase -0.429 0.535 0.425 0.651
wcaK, amsJ; colanic acid/amylovoran biosynthesis protein 2.304 1.989 0.248 0.651
wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14] -0.287 0.294 0.330 0.651
xanP; xanthine permease XanP -0.131 0.310 0.674 0.784
xapB; MFS transporter, NHS family, xanthosine permease 0.027 0.484 0.955 0.992
xerC; integrase/recombinase XerC -0.230 0.296 0.438 0.651
xerD; integrase/recombinase XerD -0.230 0.296 0.438 0.651
xlyAB; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] -1.535 1.399 0.274 0.651
xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22] -0.156 0.300 0.605 0.723
xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6] -0.230 0.296 0.438 0.651
xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6] -0.230 0.296 0.438 0.651
xylA; xylose isomerase [EC:5.3.1.5] -0.092 1.135 0.935 0.977
xylB, XYLB; xylulokinase [EC:2.7.1.17] -0.546 0.585 0.352 0.651
xylE; MFS transporter, SP family, xylose:H+ symportor 0.154 1.349 0.909 0.976
xylS, yicI; alpha-D-xyloside xylohydrolase [EC:3.2.1.177] -0.603 0.561 0.284 0.651
yaeR; glyoxylase I family protein 18.519 3411.091 0.996 0.998
yafQ; mRNA interferase YafQ [EC:3.1.-.-] -0.737 0.680 0.280 0.651
yajC; preprotein translocase subunit YajC -0.230 0.296 0.438 0.651
YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1] -0.230 0.296 0.438 0.651
ybaK, ebsC; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-] -0.754 1.120 0.502 0.651
ybaZ; methylated-DNA-protein-cysteine methyltransferase related protein -0.213 0.325 0.513 0.651
ybdG, mscM; miniconductance mechanosensitive channel -0.223 0.302 0.460 0.651
ybeB; ribosome-associated protein -0.230 0.296 0.438 0.651
ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-] -0.370 0.319 0.249 0.651
ycaJ; putative ATPase -0.230 0.296 0.438 0.651
ychF; ribosome-binding ATPase -0.230 0.296 0.438 0.651
yfbK; Ca-activated chloride channel homolog -0.248 0.303 0.415 0.651
yfiC, trmX; tRNA1Val (adenine37-N6)-methyltransferase [EC:2.1.1.223] -0.230 0.296 0.438 0.651
yfiH; polyphenol oxidase [EC:1.10.3.-] -0.230 0.296 0.438 0.651
yggS, PROSC; PLP dependent protein -0.230 0.296 0.438 0.651
yhbH; putative sigma-54 modulation protein -0.263 0.312 0.401 0.651
yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase -0.230 0.296 0.438 0.651
yjbB; phosphate:Na+ symporter -0.230 0.296 0.438 0.651
yjdF; putative membrane protein -0.084 0.350 0.811 0.894
yoeB; toxin YoeB [EC:3.1.-.-] 0.112 0.479 0.816 0.896
ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-] -0.230 0.296 0.438 0.651
yraN; putative endonuclease -0.230 0.296 0.438 0.651
yrbG; cation:H+ antiporter -0.156 0.300 0.605 0.723
ytfE, scdA; regulator of cell morphogenesis and NO signaling -0.216 0.284 0.448 0.651
zapA; cell division protein ZapA -0.219 0.301 0.468 0.651
zntA; Cd2+/Zn2+-exporting ATPase [EC:3.6.3.3 3.6.3.5] -0.201 0.284 0.481 0.651
znuA; zinc transport system substrate-binding protein -0.352 0.456 0.441 0.651
znuB; zinc transport system permease protein -0.452 0.409 0.271 0.651
znuC; zinc transport system ATP-binding protein [EC:3.6.3.-] -0.452 0.409 0.271 0.651
zraR, hydG; two-component system, NtrC family, response regulator HydG -0.512 0.991 0.606 0.723 
# merge with tb.ra for full results table
full.res <- left_join(tb.ra, results.out, by = "description")

write.csv(full.res, "output/picrust_ko_stratefied_prevo_data_results.csv", row.names = F)

sessionInfo()
R version 4.0.5 (2021-03-31)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19042)

Matrix products: default

locale:
[1] LC_COLLATE=English_United States.1252 
[2] LC_CTYPE=English_United States.1252   
[3] LC_MONETARY=English_United States.1252
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.1252    

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] cowplot_1.1.1     dendextend_1.14.0 ggdendro_0.1.22   reshape2_1.4.4   
 [5] car_3.0-10        carData_3.0-4     gvlma_1.0.0.3     patchwork_1.1.1  
 [9] viridis_0.5.1     viridisLite_0.3.0 gridExtra_2.3     xtable_1.8-4     
[13] kableExtra_1.3.4  MASS_7.3-53.1     data.table_1.14.0 readxl_1.3.1     
[17] forcats_0.5.1     stringr_1.4.0     dplyr_1.0.5       purrr_0.3.4      
[21] readr_1.4.0       tidyr_1.1.3       tibble_3.1.0      ggplot2_3.3.3    
[25] tidyverse_1.3.0   lmerTest_3.1-3    lme4_1.1-26       Matrix_1.3-2     
[29] vegan_2.5-7       lattice_0.20-41   permute_0.9-5     phyloseq_1.34.0  
[33] workflowr_1.6.2  

loaded via a namespace (and not attached):
  [1] minqa_1.2.4         colorspace_2.0-0    rio_0.5.26         
  [4] ellipsis_0.3.1      rprojroot_2.0.2     XVector_0.30.0     
  [7] fs_1.5.0            rstudioapi_0.13     farver_2.1.0       
 [10] fansi_0.4.2         lubridate_1.7.10    xml2_1.3.2         
 [13] codetools_0.2-18    splines_4.0.5       knitr_1.31         
 [16] ade4_1.7-16         jsonlite_1.7.2      nloptr_1.2.2.2     
 [19] broom_0.7.5         cluster_2.1.1       dbplyr_2.1.0       
 [22] BiocManager_1.30.10 compiler_4.0.5      httr_1.4.2         
 [25] backports_1.2.1     assertthat_0.2.1    cli_2.3.1          
 [28] later_1.1.0.1       htmltools_0.5.1.1   prettyunits_1.1.1  
 [31] tools_4.0.5         igraph_1.2.6        gtable_0.3.0       
 [34] glue_1.4.2          Rcpp_1.0.6          Biobase_2.50.0     
 [37] cellranger_1.1.0    jquerylib_0.1.3     vctrs_0.3.6        
 [40] Biostrings_2.58.0   rhdf5filters_1.2.0  multtest_2.46.0    
 [43] svglite_2.0.0       ape_5.4-1           nlme_3.1-152       
 [46] iterators_1.0.13    xfun_0.21           ps_1.6.0           
 [49] openxlsx_4.2.3      rvest_1.0.0         lifecycle_1.0.0    
 [52] statmod_1.4.35      zlibbioc_1.36.0     scales_1.1.1       
 [55] hms_1.0.0           promises_1.2.0.1    parallel_4.0.5     
 [58] biomformat_1.18.0   rhdf5_2.34.0        curl_4.3           
 [61] yaml_2.2.1          sass_0.3.1          stringi_1.5.3      
 [64] highr_0.8           S4Vectors_0.28.1    foreach_1.5.1      
 [67] BiocGenerics_0.36.0 zip_2.1.1           boot_1.3-27        
 [70] systemfonts_1.0.1   rlang_0.4.10        pkgconfig_2.0.3    
 [73] evaluate_0.14       Rhdf5lib_1.12.1     labeling_0.4.2     
 [76] tidyselect_1.1.0    plyr_1.8.6          magrittr_2.0.1     
 [79] R6_2.5.0            IRanges_2.24.1      generics_0.1.0     
 [82] DBI_1.1.1           foreign_0.8-81      pillar_1.5.1       
 [85] haven_2.3.1         withr_2.4.1         mgcv_1.8-34        
 [88] abind_1.4-5         survival_3.2-10     modelr_0.1.8       
 [91] crayon_1.4.1        utf8_1.1.4          rmarkdown_2.7      
 [94] progress_1.2.2      grid_4.0.5          git2r_0.28.0       
 [97] webshot_0.5.2       reprex_1.0.0        digest_0.6.27      
[100] httpuv_1.5.5        numDeriv_2016.8-1.1 stats4_4.0.5       
[103] munsell_0.5.0       bslib_0.2.4