PICRUSt Stratified Analyses

Streptococcus sanguinis

workflowr

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Last updated: 2021-04-15

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Knit directory: esoph-micro-cancer-workflow/

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i. Mean relative abundance in Tumors

ii. Standard error of mean in Tumors

iii. Mean relative abundance in Non-tumors

iv. Standard error of mean in Non-tumors

v. GLM differential abundance analysis between Tumor vs Non-tumor (Patient=Fixed effect)
  1. P-value
  2. FDR corrected q-value
vi. GLMM differential abundance analysis between Tumor vs Non-tumor (Patient=Random Effect)
  1.P-value
  2. FDR corrected q-value

Part 1 EC Data

# note: must rename function to func (or something else) because "function" is a reserved name in R and can't be used.

descriptions <- readr::read_tsv("data/PICRUST/ec_pred_metagenome_unstrat_descrip.tsv")[,1:2] %>%
  distinct()

-- Column specification --------------------------------------------------------
cols(
  .default = col_double(),
  `function` = col_character(),
  description = col_character()
)
i Use `spec()` for the full column specifications.

colnames(descriptions) <- c("func", "description")

pi.dat <- readxl::read_xlsx("data/PICRUST-Stratified/EC_strepto.xlsx")
colnames(pi.dat) <- c("func",  colnames(pi.dat)[-c(1)])

# add descriptions to dataframe
pi.dat <- left_join(pi.dat, descriptions, by="func")
pi.dat <- pi.dat[,c(1,161,3:160)]

# aggregate descriptions to get 1 description per row - unique;y defined.
pi.dat <- pi.dat %>%
  group_by(description) %>%
  summarise(across(`1.S37.Jun172016`:`99.D01.S37.Jun232016`,.fns = mean))

# make long format
pi.dat <- pi.dat %>%
  pivot_longer(
    cols=`1.S37.Jun172016`:`99.D01.S37.Jun232016`,
    names_to = "ID",
    values_to = "Abundance"
  )
d <- as.data.frame(dat.16s)
mydata <- full_join(pi.dat, d)

Joining, by = "ID"

Warning in class(x) <- c(setdiff(subclass, tibble_class), tibble_class): Setting
class(x) to multiple strings ("tbl_df", "tbl", ...); result will no longer be an
S4 object

mydata <- mydata %>%
  mutate(
    ID.n = as.numeric(as.factor(ID)),
    description.n = as.numeric(as.factor(description))
  ) %>%
  group_by(description)%>%
  mutate(avgA = mean(Abundance))

Abundance

I needed to change from relative abundance to abundance due to so many individuals having 0 counts for all descriptions.

d <- mydata %>%
  filter(description=="DNA-directed DNA polymerase")

t.test(d$Abundance ~ d$tumor.cat)

    Welch Two Sample t-test

data:  d$Abundance by d$tumor.cat
t = 0.685, df = 153, p-value = 0.49
alternative hypothesis: true difference in means is not equal to 0
95 percent confidence interval:
 -5.7513 11.8575
sample estimates:
mean in group Non-Tumor     mean in group Tumor 
                 25.754                  22.701 

# Run on all descriptions
tb.ra1 <- mydata %>%
  group_by(description) %>%
  summarise(ng = n(),
            Overall.M = mean(Abundance),
            Overall.SE = sd(Abundance)/sqrt(ng))
tb.ra2m <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(M = mean(Abundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = M)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2se <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(),SE = sd(Abundance)/sqrt(ng)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = SE)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2var <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(), VAR = var(Abundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = VAR)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2ng <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n()) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = ng)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra <- left_join(tb.ra1, tb.ra2m)

Joining, by = "description"

tb.ra <- cbind(tb.ra, tb.ra2se[,-1])
tb.ra <- cbind(tb.ra, tb.ra2var[,-1])
tb.ra <- cbind(tb.ra, tb.ra2ng[,-1]) 

colnames(tb.ra) <- c("description", "ng", "Overall Mean", "Overall SE", "Non-Tumor Mean", "Tumor Mean", "Non-Tumor SE", "Tumor SE","Non-Tumor Var", "Tumor Var", "Non-Tumor Ng", "Tumor Ng")
tb.ra <- tb.ra %>%
  arrange(desc(`Overall Mean`))
tb.ra <- tb.ra[, c("description", "Overall Mean", "Overall SE","Tumor Mean","Tumor Var", "Tumor SE","Tumor Ng", "Non-Tumor Mean","Non-Tumor Var", "Non-Tumor SE", "Non-Tumor Ng")]

# compute t-test
tb.ra <- tb.ra %>%
  mutate(
    SEpooled = sqrt(`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`),
    t = (`Tumor Mean` - `Non-Tumor Mean`)/(SEpooled),
    df = ((`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`)**2)/(((`Tumor Var`/`Tumor Ng`)**2)/(`Tumor Ng`-1) + ((`Non-Tumor Var`/`Non-Tumor Ng`)**2)/(`Non-Tumor Ng`-1)),
    p = pt(q = abs(t), df=df, lower.tail = F)*2,
    fdr_p = p.adjust(p, method="fdr")
  )


kable(tb.ra, format="html", digits=5, caption="Stratefied EC Data - Streptococcus sanguinis : Average Abundance of Each Description (sorted in descending order)") %>%
  kable_styling(full_width = T) %>%
  scroll_box(width = "100%", height="600px")

Stratefied EC Data - Streptococcus sanguinis : Average Abundance of Each Description (sorted in descending order)

description	Overall Mean	Overall SE	Tumor Mean	Tumor Var	Tumor SE	Tumor Ng	Non-Tumor Mean	Non-Tumor Var	Non-Tumor SE	Non-Tumor Ng	SEpooled	t	df	p	fdr_p
DNA-directed DNA polymerase	24.49838	2.27656	22.70132	617.00038	3.08096	65	25.75439	964.32390	3.22010	93	4.45661	-0.68506	153.10	0.49434	0.54516
Protein-N(pi)-phosphohistidine–sugar phosphotransferase	24.49838	2.27656	22.70132	617.00038	3.08096	65	25.75439	964.32390	3.22010	93	4.45661	-0.68506	153.10	0.49434	0.54516
DNA helicase	21.77634	2.02361	20.17895	487.50647	2.73863	65	22.89279	761.93493	2.86232	93	3.96143	-0.68506	153.10	0.49434	0.54516
Histidine kinase	20.59153	1.91208	19.08562	429.50613	2.57056	65	21.64404	684.27742	2.71253	93	3.73706	-0.68461	153.49	0.49462	0.54516
8-oxo-dGTP diphosphatase	15.63121	1.47713	14.46589	276.44703	2.06229	65	16.44568	394.37041	2.05926	93	2.91437	-0.67932	150.89	0.49798	0.54516
Exo-alpha-sialidase	11.51975	1.13130	10.71008	126.18687	1.39332	65	12.08565	256.51674	1.66080	93	2.16785	-0.63453	155.99	0.52666	0.54516
Hydroxyethylthiazole kinase	11.51975	1.13130	10.71008	126.18687	1.39332	65	12.08565	256.51674	1.66080	93	2.16785	-0.63453	155.99	0.52666	0.54516
Pyridoxal 5’-phosphate synthase (glutamine hydrolyzing)	11.51975	1.13130	10.71008	126.18687	1.39332	65	12.08565	256.51674	1.66080	93	2.16785	-0.63453	155.99	0.52666	0.54516
Thiamine-phosphate diphosphorylase	11.51975	1.13130	10.71008	126.18687	1.39332	65	12.08565	256.51674	1.66080	93	2.16785	-0.63453	155.99	0.52666	0.54516
Uroporphyrinogen decarboxylase	11.51975	1.13130	10.71008	126.18687	1.39332	65	12.08565	256.51674	1.66080	93	2.16785	-0.63453	155.99	0.52666	0.54516
Polar-amino-acid-transporting ATPase	11.23806	1.04586	10.42313	123.83431	1.38027	65	11.80763	207.98515	1.49546	93	2.03508	-0.68032	154.42	0.49732	0.54516
DNA-directed RNA polymerase	10.88817	1.01180	10.08948	121.87662	1.36932	65	11.44639	190.48373	1.43116	93	1.98072	-0.68506	153.10	0.49434	0.54516
Type I site-specific deoxyribonuclease	10.53322	0.98944	9.75172	122.25442	1.37144	65	11.07942	178.18759	1.38419	93	1.94855	-0.68138	151.46	0.49667	0.54516
Phosphoglycerate mutase (2,3-diphosphoglycerate-independent)	9.00231	0.85848	8.32782	94.85856	1.20804	65	9.47373	132.18135	1.19218	93	1.69725	-0.67516	150.24	0.50061	0.54516
Galactose-6-phosphate isomerase	8.51855	0.79469	7.90281	70.30952	1.04004	65	8.94890	120.91553	1.14025	93	1.54332	-0.67782	154.77	0.49890	0.54516
23S rRNA pseudouridine(1911/1915/1917) synthase	8.16613	0.75885	7.56711	68.55560	1.02699	65	8.58480	107.14710	1.07337	93	1.48554	-0.68506	153.10	0.49434	0.54516
Asparaginyl-tRNA synthase (glutamine-hydrolyzing)	8.16613	0.75885	7.56711	68.55560	1.02699	65	8.58480	107.14710	1.07337	93	1.48554	-0.68506	153.10	0.49434	0.54516
Cysteine desulfurase	8.16613	0.75885	7.56711	68.55560	1.02699	65	8.58480	107.14710	1.07337	93	1.48554	-0.68506	153.10	0.49434	0.54516
Glutaminyl-tRNA synthase (glutamine-hydrolyzing)	8.16613	0.75885	7.56711	68.55560	1.02699	65	8.58480	107.14710	1.07337	93	1.48554	-0.68506	153.10	0.49434	0.54516
Peptidylprolyl isomerase	8.16613	0.75885	7.56711	68.55560	1.02699	65	8.58480	107.14710	1.07337	93	1.48554	-0.68506	153.10	0.49434	0.54516
Tryptophan synthase	8.16613	0.75885	7.56711	68.55560	1.02699	65	8.58480	107.14710	1.07337	93	1.48554	-0.68506	153.10	0.49434	0.54516
Acetyl-CoA carboxylase	8.16486	0.75886	7.56608	68.55893	1.02701	65	8.58336	107.14706	1.07337	93	1.48555	-0.68478	153.10	0.49452	0.54516
Ribosomal-protein-alanine N-acetyltransferase	7.81624	0.73857	7.23346	69.10934	1.03113	65	8.22356	98.59577	1.02965	93	1.45719	-0.67946	150.90	0.49789	0.54516
Serine-type D-Ala-D-Ala carboxypeptidase	7.81624	0.73857	7.23346	69.10934	1.03113	65	8.22356	98.59577	1.02965	93	1.45719	-0.67946	150.90	0.49789	0.54516
Site-specific DNA-methyltransferase (adenine-specific)	7.81244	0.73855	7.23038	69.12434	1.03124	65	8.21925	98.57819	1.02955	93	1.45720	-0.67861	150.89	0.49842	0.54516
Phosphate-transporting ATPase	6.98005	0.64885	6.47275	48.14762	0.86066	65	7.33462	79.71352	0.92582	93	1.26407	-0.68182	154.19	0.49638	0.54516
Ribonuclease H	6.98005	0.64885	6.47275	48.14762	0.86066	65	7.33462	79.71352	0.92582	93	1.26407	-0.68182	154.19	0.49638	0.54516
Alcohol dehydrogenase	6.63016	0.62059	6.13910	47.64621	0.85617	65	6.97338	70.40897	0.87011	93	1.22070	-0.68344	151.81	0.49537	0.54516
H(+)-transporting two-sector ATPase	6.63016	0.62059	6.13910	47.64621	0.85617	65	6.97338	70.40897	0.87011	93	1.22070	-0.68344	151.81	0.49537	0.54516
[Formate-C-acetyltransferase]-activating enzyme	6.62889	0.62059	6.13807	47.64976	0.85620	65	6.97194	70.40586	0.87009	93	1.22071	-0.68310	151.81	0.49558	0.54516
Transketolase	6.20647	0.58424	5.76146	36.76504	0.75207	65	6.51750	66.21996	0.84383	93	1.13034	-0.66887	155.32	0.50457	0.54516
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
6-carboxytetrahydropterin synthase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
6-pyruvoyltetrahydropterin synthase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
7-carboxy-7-deazaguanine synthase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
7-cyano-7-deazaguanine synthase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Adenylate cyclase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Agmatine deiminase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Aminopyrimidine aminohydrolase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Arginine decarboxylase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Aspartate–ammonia ligase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Carboxynorspermidine decarboxylase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Cephalosporin-C deacetylase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Dolichyl-phosphate beta-D-mannosyltransferase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Fe(3+)-transporting ATPase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Glucan 1,6-alpha-glucosidase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Glycerone kinase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Hydroxymethylpyrimidine kinase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Lysine decarboxylase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
N-carbamoylputrescine amidase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Nucleoside-diphosphate kinase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Phosphomethylpyrimidine kinase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
PreQ(1) synthase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Pyroglutamyl-peptidase I	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Ribitol-5-phosphate 2-dehydrogenase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Saccharopine dehydrogenase (NAD(+), L-lysine-forming)	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Spermidine synthase	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.54516
Uracil phosphoribosyltransferase	5.44535	0.50590	5.04576	30.46705	0.68463	65	5.72463	47.62128	0.71558	93	0.99034	-0.68549	153.10	0.49407	0.54516
(R)-2-methylmalate dehydratase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
16S rRNA pseudouridine(516) synthase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
3-isopropylmalate dehydratase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
3-oxoacyl-[acyl-carrier-protein] reductase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Acetolactate synthase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Anthranilate synthase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Carbamoyl-phosphate synthase (glutamine-hydrolyzing)	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
D-alanine–poly(phosphoribitol) ligase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Dihydrofolate synthase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
DNA-(apurinic or apyrimidinic site) lyase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
DNA topoisomerase (ATP-hydrolyzing)	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Exodeoxyribonuclease VII	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Glucose-1-phosphate adenylyltransferase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Glycerol-3-phosphate 1-O-acyltransferase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Glycine–tRNA ligase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
GTP diphosphokinase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Iron-chelate-transporting ATPase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
L-serine ammonia-lyase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Peptide-methionine (R)-S-oxide reductase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Peptide-methionine (S)-S-oxide reductase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Peptide deformylase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Phenylalanine–tRNA ligase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Phosphoribosylanthranilate isomerase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Protein-serine/threonine phosphatase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Purine-nucleoside phosphorylase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Pyruvate dehydrogenase (acetyl-transferring)	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Ribonucleoside-diphosphate reductase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Ribonucleoside-triphosphate reductase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Ribose-phosphate diphosphokinase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
RNA helicase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Tetrahydrofolate synthase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Thioredoxin-disulfide reductase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
UDP-glucose 4-epimerase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
Undecaprenyl-diphosphate phosphatase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.54516
3-deoxy-7-phosphoheptulonate synthase	5.44282	0.50591	5.04371	30.47140	0.68468	65	5.72176	47.62097	0.71558	93	0.99038	-0.68464	153.10	0.49461	0.54516
6-phospho-beta-glucosidase	5.09419	0.48981	4.71109	31.22347	0.69308	65	5.36196	42.79143	0.67832	93	0.96979	-0.67115	149.75	0.50316	0.54516
Pullulanase	5.09293	0.48980	4.71006	31.22724	0.69312	65	5.36052	42.78526	0.67827	93	0.96978	-0.67073	149.74	0.50343	0.54516
Sortase A	5.09293	0.48980	4.71006	31.22724	0.69312	65	5.36052	42.78526	0.67827	93	0.96978	-0.67073	149.74	0.50343	0.54516
Alpha-L-fucosidase	4.61549	0.45235	4.29018	20.19631	0.55742	65	4.84286	40.99446	0.66393	93	0.86690	-0.63753	155.99	0.52471	0.54516
DNA (cytosine-5-)-methyltransferase	4.61549	0.45235	4.29018	20.19631	0.55742	65	4.84286	40.99446	0.66393	93	0.86690	-0.63753	155.99	0.52471	0.54516
(S,S)-butanediol dehydrogenase	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.54516
Alpha-mannosidase	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.54516
Diacetyl reductase ((S)-acetoin forming)	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.54516
Diamine N-acetyltransferase	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.54516
UDP-N-acetylglucosamine kinase	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.54516
D-alanine–D-alanine ligase	4.25801	0.39736	3.95038	17.57818	0.52003	65	4.47302	30.23167	0.57015	93	0.77169	-0.67726	154.77	0.49925	0.54516
4-hydroxy-tetrahydrodipicolinate reductase	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.54516
ADP-ribose diphosphatase	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.54516
Arsenate reductase (glutaredoxin)	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.54516
Aspartate–tRNA ligase	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.54516
Beta-galactosidase	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.54516
Formate–tetrahydrofolate ligase	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.54516
Glutamate dehydrogenase (NADP(+))	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.54516
Glycogen phosphorylase	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.54516
N(6)-L-threonylcarbamoyladenine synthase	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.54516
Protein-tyrosine-phosphatase	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.54516
Pyridoxal kinase	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.54516
Signal peptidase I	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.54516
Xaa-Pro dipeptidyl-peptidase	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.54516
Formate C-acetyltransferase	3.90685	0.36928	3.61570	17.27980	0.51560	65	4.11034	24.64592	0.51479	93	0.72860	-0.67890	150.89	0.49824	0.54516
Pyruvate, water dikinase	3.23475	0.34040	2.98462	15.93997	0.49521	65	3.40958	20.07809	0.46464	93	0.67906	-0.62581	147.02	0.53241	0.54516
Beta-fructofuranosidase	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.54516
Chorismate mutase	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.54516
Cu(+) exporting ATPase	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.54516
DNA topoisomerase	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.54516
Glucose-6-phosphate isomerase	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.54516
GMP synthase (glutamine-hydrolyzing)	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.54516
L-lactate dehydrogenase	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.54516
Polyribonucleotide nucleotidyltransferase	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.54516
Tagatose-6-phosphate kinase	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.54516
Tagatose-bisphosphate aldolase	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.54516
Uridine kinase	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.54516
(2E,6E)-farnesyl diphosphate synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
(FADH(2)-oxidizing)	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
[Acyl-carrier-protein] S-malonyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
1-acylglycerol-3-phosphate O-acyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
1-phosphofructokinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
1,4-alpha-glucan branching enzyme	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
16S rRNA (cytidine(1402)-2’-O)-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
16S rRNA (cytidine(1409)-2’-O)-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
16S rRNA (cytosine(1402)-N(4))-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
16S rRNA (cytosine(967)-C(5))-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
16S rRNA (guanine(1207)-N(2))-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
16S rRNA (guanine(527)-N(7))-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
16S rRNA (guanine(966)-N(2))-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
16S rRNA (uracil(1498)-N(3))-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
2-hydroxymuconate tautomerase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
2-iminobutanoate/2-iminopropanoate deaminase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
2-isopropylmalate synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
23S rRNA (adenine(2503)-C(2))-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
23S rRNA (cytidine(1920)-2’-O)-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
23S rRNA (cytosine(1962)-C(5))-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
23S rRNA (guanine(745)-N(1))-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
23S rRNA (guanosine(2251)-2’-O)-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
23S rRNA (pseudouridine(1915)-N(3))-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
23S rRNA (uracil(1939)-C(5))-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
23S rRNA pseudouridine(2605) synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
3’(2’),5’-bisphosphate nucleotidase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
3-dehydroquinate dehydratase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
3-dehydroquinate synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
3-hydroxyacyl-[acyl-carrier-protein] dehydratase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
3-isopropylmalate dehydrogenase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
3-phosphoshikimate 1-carboxyvinyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
4-alpha-glucanotransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
4-hydroxy-tetrahydrodipicolinate synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
4-nitrophenylphosphatase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
5-(carboxyamino)imidazole ribonucleotide mutase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
5-(carboxyamino)imidazole ribonucleotide synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
5-formyltetrahydrofolate cyclo-ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
5-methyltetrahydropteroyltriglutamate–homocysteine S-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
6-phospho-beta-galactosidase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
6-phosphofructokinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
6-phosphogluconolactonase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Acetaldehyde dehydrogenase (acetylating)	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Acetate kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Acetolactate decarboxylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
acetylglucosaminyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Acylphosphatase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Adenine phosphoribosyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Adenosylhomocysteine nucleosidase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Adenylate kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Adenylosuccinate lyase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Adenylosuccinate synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Alanine–tRNA ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Alanine racemase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Alanine transaminase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Aldose 1-epimerase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Alpha-amylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Amidophosphoribosyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Aminoacyl-tRNA hydrolase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Aminodeoxychorismate lyase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Aminodeoxychorismate synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Anthranilate phosphoribosyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Arginine–tRNA ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Asparaginase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Asparagine–tRNA ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Aspartate-semialdehyde dehydrogenase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Aspartate carbamoyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Aspartate kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Beta-ketoacyl-[acyl-carrier-protein] synthase II	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Beta-ketoacyl-[acyl-carrier-protein] synthase III	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Beta-lactamase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Biotin–[acetyl-CoA-carboxylase] ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Biotin carboxylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Bleomycin hydrolase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Branched-chain-amino-acid transaminase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Calcium-transporting ATPase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Carbonate dehydratase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Catechol 2,3-dioxygenase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
CCA tRNA nucleotidyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Chorismate synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Coproporphyrinogen dehydrogenase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
CTP synthase (glutamine hydrolyzing)	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Cystathionine beta-lyase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Cystathionine gamma-synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Cysteine–tRNA ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Cysteine synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Cytidine deaminase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
dCMP deaminase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Deoxyribose-phosphate aldolase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Dephospho-CoA kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Diadenylate cyclase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Diaminopimelate decarboxylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Dihydrofolate reductase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Dihydrolipoyl dehydrogenase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Dihydrolipoyllysine-residue acetyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Dihydroneopterin aldolase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Dihydroorotase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Dihydroorotate dehydrogenase (NAD(+))	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Dihydroorotate oxidase (fumarate)	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Dihydropteroate synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Dihydroxy-acid dehydratase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Dimethylallyltranstransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
diphosphate specific)	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Diphosphomevalonate decarboxylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
DNA-3-methyladenine glycosylase I	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
DNA-formamidopyrimidine glycosylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
DNA ligase (NAD(+))	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Dodecanoyl-[acyl-carrier-protein] hydrolase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
dTMP kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
dUTP diphosphatase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Endopeptidase Clp	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Enoyl-[acyl-carrier-protein] reductase (NADH)	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Exodeoxyribonuclease III	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Exodeoxyribonuclease V	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
FAD synthetase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Ferrochelatase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Fructose-bisphosphate aldolase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Galactokinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Geranylgeranyl diphosphate synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glucokinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glucosamine-1-phosphate N-acetyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glucosamine-6-phosphate deaminase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glucose-6-phosphate dehydrogenase (NAD(P)(+))	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glucose-6-phosphate dehydrogenase (NADP(+))	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glutamate–ammonia ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glutamate–tRNA(Gln) ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glutamate-5-semialdehyde dehydrogenase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glutamate 5-kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glutamate racemase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glutamine–fructose-6-phosphate transaminase (isomerizing)	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glutamyl aminopeptidase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glutathione-disulfide reductase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glutathione peroxidase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glycerate 3-kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glycerol-3-phosphate dehydrogenase (NAD(P)(+))	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glycerol-3-phosphate oxidase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glycerol kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glycerophosphodiester phosphodiesterase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Glycine hydroxymethyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
GMP reductase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
GTP cyclohydrolase I	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Guanylate kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Histidine–tRNA ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Holo-[acyl-carrier-protein] synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Homoserine dehydrogenase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Homoserine kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Homoserine O-succinyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Hydroxymethylglutaryl-CoA reductase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Hydroxymethylglutaryl-CoA synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Hypoxanthine phosphoribosyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
IMP cyclohydrolase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
IMP dehydrogenase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Indole-3-glycerol-phosphate synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Inorganic diphosphatase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Inositol-phosphate phosphatase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Isoleucine–tRNA ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Isopentenyl-diphosphate Delta-isomerase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Ketol-acid reductoisomerase (NADP(+))	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
L-threonylcarbamoyladenylate synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Lactoylglutathione lyase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Leucine–tRNA ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Lipoate–protein ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Lysine–tRNA ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Magnesium-importing ATPase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Maltose 6’-phosphate phosphatase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Maltose O-acetyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Mannose-6-phosphate isomerase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Membrane alanyl aminopeptidase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Methenyltetrahydrofolate cyclohydrolase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Methionine–tRNA ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Methionine adenosyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Methionyl-tRNA formyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Methionyl aminopeptidase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Methylated-DNA–[protein]-cysteine S-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Methylenetetrahydrofolate dehydrogenase (NADP(+))	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Methylenetetrahydrofolate reductase (NAD(P)H)	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Mevalonate kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Monosaccharide-transporting ATPase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
N-acetyldiaminopimelate deacetylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
N-acetylglucosamine-6-phosphate deacetylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
N-acetylneuraminate lyase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
N-acylglucosamine-6-phosphate 2-epimerase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
NAD(+) kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
NAD(+) synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Neopullulanase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Nicotinamide-nucleotide amidase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Nicotinate-nucleotide adenylyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Nicotinate phosphoribosyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Non-specific serine/threonine protein kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
O-acetylhomoserine aminocarboxypropyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Oligonucleotidase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Orotate phosphoribosyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Orotidine-5’-phosphate decarboxylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Pantetheine-phosphate adenylyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Pantothenate kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Peptidase Do	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Peptide chain release factor N(5)-glutamine methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Peptidoglycan glycosyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Peroxiredoxin	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphate acetyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphatidate cytidylyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phospho-N-acetylmuramoyl-pentapeptide-transferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphoenolpyruvate–protein phosphotransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphoenolpyruvate carboxylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphogluconate dehydrogenase (NAD(+)-dependent, decarboxylating)	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphoglucosamine mutase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphoglycerate kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphoglycolate phosphatase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphomevalonate kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphopantothenate–cysteine ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphopantothenoylcysteine decarboxylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphopentomutase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphopyruvate hydratase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphoribosylamine–glycine ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphoribosylaminoimidazolecarboxamide formyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphoribosylaminoimidazolesuccinocarboxamide synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphoribosylformylglycinamidine cyclo-ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphoribosylformylglycinamidine synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphoribosylglycinamide formyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Phosphoserine phosphatase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Polyamine-transporting ATPase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Prephenate dehydratase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Prephenate dehydrogenase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Prepilin peptidase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Proline–tRNA ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Pyrimidine-nucleoside phosphorylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Pyrroline-5-carboxylate reductase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Pyruvate kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Pyruvate oxidase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Riboflavin kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Ribonuclease III	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Ribonuclease M5	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Ribonuclease P	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Ribonuclease Z	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Ribose-5-phosphate isomerase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Ribulose-phosphate 3-epimerase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
S-adenosylhomocysteine deaminase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
S-adenosylmethionine:tRNA ribosyltransferase-isomerase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
S-methyl-5’-thioadenosine deaminase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
S-ribosylhomocysteine lyase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Selenocysteine lyase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Serine–tRNA ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Serine O-acetyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Shikimate dehydrogenase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Shikimate kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Signal peptidase II	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Starch synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Succinyl-diaminopimelate desuccinylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Superoxide dismutase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Tellurite methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Thiamine diphosphokinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Threonine–tRNA ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Threonine ammonia-lyase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Threonine synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Thymidine kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Thymidylate synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Trans-2-decenoyl-[acyl-carrier-protein] isomerase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Triose-phosphate isomerase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Tripeptide aminopeptidase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
tRNA-guanine(34) transglycosylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
tRNA (adenine(22)-N(1))-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
tRNA (cytidine(34)-2’-O)-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
tRNA (guanine(37)-N(1))-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
tRNA (guanine(46)-N(7))-methyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
tRNA dimethylallyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
tRNA pseudouridine(38-40) synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
tRNA pseudouridine(55) synthase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
tRNA(adenine(34)) deaminase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
tRNA(Ile)-lysidine synthetase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Tryptophan–tRNA ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Tyrosine–tRNA ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
UDP-glucose–hexose-1-phosphate uridylyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
UDP-N-acetylglucosamine diphosphorylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
UDP-N-acetylmuramate–L-alanine ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
UDP-N-acetylmuramate dehydrogenase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
UDP-N-acetylmuramoyl-L-alanine–D-glutamate ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–L-lysine ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
UMP kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
UMP/CMP kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Undecaprenol kinase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Uracil-DNA glycosylase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
UTP–glucose-1-phosphate uridylyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Valine–pyruvate transaminase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Valine–tRNA ligase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Xaa-Pro aminopeptidase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Xaa-Pro dipeptidase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
Xanthine phosphoribosyltransferase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
XTP/dITP diphosphatase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.54516
2’,3’-cyclic-nucleotide 2’-phosphodiesterase	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.54516
3’-nucleotidase	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.54516
3-dehydro-L-gulonate-6-phosphate decarboxylase	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.54516
Alpha-galactosidase	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.54516
Epoxyqueuosine reductase	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.54516
Fructose-bisphosphatase	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.54516
Glyceraldehyde-3-phosphate dehydrogenase (NADP(+))	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.54516
Glycerol dehydrogenase	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.54516
Homocysteine S-methyltransferase	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.54516
L-ribulose-5-phosphate 4-epimerase	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.54516
Phosphoenolpyruvate carboxykinase (ATP)	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.54516
Phosphoglycerate dehydrogenase	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.54516
Phosphoserine transaminase	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.54516
Sucrose phosphorylase	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.54516
Lactocepin	1.62083	0.17031	1.49510	3.98064	0.24747	65	1.70870	5.03262	0.23262	93	0.33964	-0.62889	147.15	0.53040	0.54516
Acetylornithine transaminase	1.61910	0.17025	1.49371	3.98269	0.24753	65	1.70674	5.02571	0.23246	93	0.33958	-0.62737	147.08	0.53139	0.54516
Beta-N-acetylhexosaminidase	1.61910	0.17025	1.49371	3.98269	0.24753	65	1.70674	5.02571	0.23246	93	0.33958	-0.62737	147.08	0.53139	0.54516
(R,R)-butanediol dehydrogenase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
23S rRNA pseudouridine(746) synthase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
4-hydroxybenzoate polyprenyltransferase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
5’-nucleotidase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Acetylglutamate kinase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Aconitate hydratase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Alanine dehydrogenase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Alpha,alpha-phosphotrehalase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Amino-acid N-acetyltransferase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Arginine deiminase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Argininosuccinate lyase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Argininosuccinate synthase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
ATP phosphoribosyltransferase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Carbamate kinase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
CDP-diacylglycerol–serine O-phosphatidyltransferase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Citrate (Si)-synthase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Dextransucrase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Diacetyl reductase ((R)-acetoin forming)	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Diacylglycerol kinase (ATP)	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Diglucosyl diacylglycerol synthase (1,2-linking)	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Dipeptidase E	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
dTDP-4-dehydrorhamnose 3,5-epimerase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
dTDP-4-dehydrorhamnose reductase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
dTDP-glucose 4,6-dehydratase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Formimidoylglutamase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Formimidoyltetrahydrofolate cyclodeaminase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Fructan beta-fructosidase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Fructokinase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Glucose-1-phosphate thymidylyltransferase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Glutamate–cysteine ligase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Glutamate formimidoyltransferase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Glutamate N-acetyltransferase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Histidine ammonia-lyase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Histidinol-phosphatase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Histidinol-phosphate transaminase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Histidinol dehydrogenase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Imidazoleglycerol-phosphate dehydratase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Imidazolonepropionase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Isocitrate dehydrogenase (NADP(+))	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
isomerase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Kanamycin kinase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
N-acetyl-gamma-glutamyl-phosphate reductase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
N-acetylglucosaminephosphotransferase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
NAD(P)H dehydrogenase (quinone)	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Ornithine carbamoyltransferase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Phosphatidylglycerol–membrane-oligosaccharide glycerophosphotransferase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Phosphatidylserine decarboxylase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Phosphinothricin acetyltransferase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Phosphoribosyl-AMP cyclohydrolase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Phosphoribosyl-ATP diphosphatase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Poly(glycerol-phosphate) alpha-glucosyltransferase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Pyruvate, phosphate dikinase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
tRNA pseudouridine(32) synthase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
Urocanate hydratase	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.54516
2-dehydropantoate 2-reductase	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
4-carboxymuconolactone decarboxylase	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
Aspartate racemase	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
Fructose-6-phosphate phosphoketolase	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
Hydroxyacylglutathione hydrolase	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
L-threonine aldolase	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
Malate dehydrogenase (oxaloacetate-decarboxylating)	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
Phosphoketolase	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
Quaternary-amine-transporting ATPase	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
Sorbitol-6-phosphate 2-dehydrogenase	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
UDP-galactopyranose mutase	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725

plot.dat <- tb.ra %>%
  arrange(p) %>%
  slice_head(n=50)%>%
  mutate(
    description = fct_reorder(description, `Overall Mean`),
    description = factor(description, levels = levels(description), ordered=T)
  ) %>%
  arrange(description) %>%
  mutate(
    id = 1:n(),
    step = ifelse(id%%2 == 0, 1, 0),
    Mean_diff = `Tumor Mean` - `Non-Tumor Mean`,
    diff_se = SEpooled,
    Mean_diff_ll = Mean_diff - qt(0.975, df)*diff_se,
    Mean_diff_ul = Mean_diff + qt(0.975, df)*diff_se
  ) %>%
  pivot_longer(
    cols=contains("Mean"),
    names_to = "group",
    values_to = "mean"
  )



p1.d <- plot.dat %>%
  filter(group %in% c("Tumor Mean","Non-Tumor Mean")) %>%
  mutate(
    group = ifelse(group == "Tumor Mean", "Tumor", "Non-Tumor"),
    col = ifelse(step == 1, "grey90", "white"),
    h=1, w=Inf
    
  )
p1 <- ggplot()+
  geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_bar(data=p1.d,
             aes(x=mean, y=description,
                 group=group, color=group,
                 fill=group),
             stat="identity",position = "dodge",
             alpha = 1)+
    labs(x="Mean Abundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      plot.margin = unit(c(1,0,1,1), "lines")
    )

p2.d <- plot.dat %>%
  filter(group %in% c("Mean_diff", "Mean_diff_ll", "Mean_diff_ul")) %>%
  pivot_wider(
    names_from = group,
    values_from = mean
  ) %>%
  mutate(
    group = ifelse(Mean_diff > 0, "Tumor", "Non-Tumor"),
    p = sprintf("%.3f", round(p,3)),
    ll = min(Mean_diff_ll)-0.01,
    ul = max(Mean_diff_ul)+0.01
  )
p2<-ggplot(p2.d, aes(x=Mean_diff, y=description))+
    geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_vline(xintercept = 0, linetype="dashed", alpha=0.5)+
    geom_segment(aes(x=Mean_diff_ll, y=description, xend=Mean_diff_ul, yend=description))+
    geom_point(aes(fill=group, color=group))+
    geom_text(aes(label=p, x=unique(ul)+0.1))+
    coord_cartesian(xlim = c(unique(p2.d$ll), unique(p2.d$ul)),
                    clip = 'off') +
    annotate("text", x=unique(p2.d$ul)+0.2,y = 25,
             angle=90,
             label="p-value (uncorrected)")+
    labs(x="Mean Difference in Abundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      axis.title.y = element_blank(),
      axis.text.y = element_blank(),
      axis.line.y = element_blank(),
      axis.ticks.y = element_blank(),
      plot.margin = unit(c(1,4,1,0), "lines")
    )

# plot
p1 + p2 +
  plot_annotation(title="Stratefied EC Data - Streptococcus sanguinis : First 50 descriptions with lowest p-value (uncorrected)")

Modeling Difference between Tumor and Non-Tumor

For the modeling, we used a generalized linear mixed model (GLMM).

First, we looked at the biserial correlation between the abundance of each description and the tumor status.

tb <- mydata %>%
  group_by(description)%>%
  summarise(
    r = cor(tumor, Abundance)
  ) %>%
  mutate(
    M=mean(r)
  )

ggplot(tb, aes(x=r))+
  geom_density()+
  geom_vline(aes(xintercept = M))+
  labs(x="Biserial Correlation",title="Relationship between description abundance and tumor (tumor vs. non-tumor)")+
  theme(panel.grid = element_blank())

Next, we need the data to be on an interpretable scale. First, let’s use the raw abundance like scale.

p <- ggplot(mydata, aes(x=Abundance))+
  geom_density()
p

mydata <- mydata %>%
  mutate(Abundance.dich=ifelse(Abundance==0, 0, 1))
table(mydata$Abundance.dich)

    0     1 
11460 69436 

Let’s first run models by description so that we can avoid the nesting issue initially. We will come back to this to conduct the final model (it will be more powerful).

DESCRIPTIONS <- unique(mydata$description)
i<-1
dat0 <- mydata %>% filter(description==DESCRIPTIONS[i])

# quasipossion (approximately negative binom) give an approx. answer.
fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
summary(fit0)

Call:
glm(formula = Abundance ~ 1 + tumor, family = quasipoisson(link = "log"), 
    data = dat0)

Deviance Residuals: 
   Min      1Q  Median      3Q     Max  
-2.392  -2.036  -0.885   1.016   4.266  

Coefficients:
            Estimate Std. Error t value Pr(>|t|)    
(Intercept)    1.051      0.118    8.93  1.1e-15 ***
tumor         -0.126      0.191   -0.66     0.51    
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for quasipoisson family taken to be 3.6927)

    Null deviance: 550.16  on 157  degrees of freedom
Residual deviance: 548.53  on 156  degrees of freedom
AIC: NA

Number of Fisher Scoring iterations: 5

Run over all descriptors

results.out <- as.data.frame(matrix(ncol=4, nrow=length(DESCRIPTIONS)))
colnames(results.out) <- c("description", "Est", "SE", "p")
#results.out$description <-DESCRIPTIONS

i <- 1
for(i in 1:length(DESCRIPTIONS)){
#for(i in 1:5){ 
  dat0 <- mydata %>%
    filter(description == DESCRIPTIONS[i])
  fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
  fit.sum <- summary(fit0)
  results.out[i, 1] <- DESCRIPTIONS[i]
  results.out[i, 2:4] <- fit.sum$coefficients[2, c(1,2,4)]
}

results.out$fdr_p <- p.adjust(results.out$p, method="fdr")

kable(results.out, format="html", digits=3) %>%
  kable_styling(full_width = T)%>%
  scroll_box(width="100%", height="600px")

description	Est	SE	p	fdr_p
(2E,6E)-farnesyl diphosphate synthase	-0.126	0.191	0.509	0.560
(FADH(2)-oxidizing)	-0.126	0.191	0.509	0.560
(R)-2-methylmalate dehydratase	-0.126	0.191	0.509	0.560
(R,R)-butanediol dehydrogenase	-0.133	0.217	0.540	0.560
(S,S)-butanediol dehydrogenase	-0.121	0.201	0.547	0.560
[Acyl-carrier-protein] S-malonyltransferase	-0.126	0.191	0.509	0.560
[Formate-C-acetyltransferase]-activating enzyme	-0.127	0.192	0.509	0.560
1-acylglycerol-3-phosphate O-acyltransferase	-0.126	0.191	0.509	0.560
1-phosphofructokinase	-0.126	0.191	0.509	0.560
1,4-alpha-glucan branching enzyme	-0.126	0.191	0.509	0.560
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase	-0.126	0.191	0.509	0.560
16S rRNA (cytidine(1402)-2’-O)-methyltransferase	-0.126	0.191	0.509	0.560
16S rRNA (cytidine(1409)-2’-O)-methyltransferase	-0.126	0.191	0.509	0.560
16S rRNA (cytosine(1402)-N(4))-methyltransferase	-0.126	0.191	0.509	0.560
16S rRNA (cytosine(967)-C(5))-methyltransferase	-0.126	0.191	0.509	0.560
16S rRNA (guanine(1207)-N(2))-methyltransferase	-0.126	0.191	0.509	0.560
16S rRNA (guanine(527)-N(7))-methyltransferase	-0.126	0.191	0.509	0.560
16S rRNA (guanine(966)-N(2))-methyltransferase	-0.126	0.191	0.509	0.560
16S rRNA (uracil(1498)-N(3))-methyltransferase	-0.126	0.191	0.509	0.560
16S rRNA pseudouridine(516) synthase	-0.126	0.191	0.509	0.560
2’,3’-cyclic-nucleotide 2’-phosphodiesterase	-0.133	0.217	0.541	0.560
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase	-0.126	0.191	0.509	0.560
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-0.121	0.201	0.548	0.560
2-dehydropantoate 2-reductase	-0.335	1.544	0.829	0.829
2-hydroxymuconate tautomerase	-0.126	0.191	0.509	0.560
2-iminobutanoate/2-iminopropanoate deaminase	-0.126	0.191	0.509	0.560
2-isopropylmalate synthase	-0.126	0.191	0.509	0.560
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	-0.126	0.191	0.509	0.560
23S rRNA (adenine(2503)-C(2))-methyltransferase	-0.126	0.191	0.509	0.560
23S rRNA (cytidine(1920)-2’-O)-methyltransferase	-0.126	0.191	0.509	0.560
23S rRNA (cytosine(1962)-C(5))-methyltransferase	-0.126	0.191	0.509	0.560
23S rRNA (guanine(745)-N(1))-methyltransferase	-0.126	0.191	0.509	0.560
23S rRNA (guanosine(2251)-2’-O)-methyltransferase	-0.126	0.191	0.509	0.560
23S rRNA (pseudouridine(1915)-N(3))-methyltransferase	-0.126	0.191	0.509	0.560
23S rRNA (uracil(1939)-C(5))-methyltransferase	-0.126	0.191	0.509	0.560
23S rRNA pseudouridine(1911/1915/1917) synthase	-0.126	0.191	0.509	0.560
23S rRNA pseudouridine(2605) synthase	-0.126	0.191	0.509	0.560
23S rRNA pseudouridine(746) synthase	-0.133	0.217	0.540	0.560
3’-nucleotidase	-0.133	0.217	0.541	0.560
3’(2’),5’-bisphosphate nucleotidase	-0.126	0.191	0.509	0.560
3-dehydro-L-gulonate-6-phosphate decarboxylase	-0.133	0.217	0.541	0.560
3-dehydroquinate dehydratase	-0.126	0.191	0.509	0.560
3-dehydroquinate synthase	-0.126	0.191	0.509	0.560
3-deoxy-7-phosphoheptulonate synthase	-0.126	0.191	0.510	0.560
3-hydroxyacyl-[acyl-carrier-protein] dehydratase	-0.126	0.191	0.509	0.560
3-isopropylmalate dehydratase	-0.126	0.191	0.509	0.560
3-isopropylmalate dehydrogenase	-0.126	0.191	0.509	0.560
3-oxoacyl-[acyl-carrier-protein] reductase	-0.126	0.191	0.509	0.560
3-phosphoshikimate 1-carboxyvinyltransferase	-0.126	0.191	0.509	0.560
4-alpha-glucanotransferase	-0.126	0.191	0.509	0.560
4-carboxymuconolactone decarboxylase	-0.335	1.544	0.829	0.829
4-hydroxy-tetrahydrodipicolinate reductase	-0.128	0.194	0.510	0.560
4-hydroxy-tetrahydrodipicolinate synthase	-0.126	0.191	0.509	0.560
4-hydroxybenzoate polyprenyltransferase	-0.133	0.217	0.540	0.560
4-nitrophenylphosphatase	-0.126	0.191	0.509	0.560
5’-nucleotidase	-0.133	0.217	0.540	0.560
5-(carboxyamino)imidazole ribonucleotide mutase	-0.126	0.191	0.509	0.560
5-(carboxyamino)imidazole ribonucleotide synthase	-0.126	0.191	0.509	0.560
5-formyltetrahydrofolate cyclo-ligase	-0.126	0.191	0.509	0.560
5-methyltetrahydropteroyltriglutamate–homocysteine S-methyltransferase	-0.126	0.191	0.509	0.560
6-carboxytetrahydropterin synthase	-0.121	0.201	0.548	0.560
6-phospho-beta-galactosidase	-0.126	0.191	0.509	0.560
6-phospho-beta-glucosidase	-0.129	0.198	0.514	0.560
6-phosphofructokinase	-0.126	0.191	0.509	0.560
6-phosphogluconolactonase	-0.126	0.191	0.509	0.560
6-pyruvoyltetrahydropterin synthase	-0.121	0.201	0.548	0.560
7-carboxy-7-deazaguanine synthase	-0.121	0.201	0.548	0.560
7-cyano-7-deazaguanine synthase	-0.121	0.201	0.548	0.560
8-oxo-dGTP diphosphatase	-0.128	0.194	0.510	0.560
Acetaldehyde dehydrogenase (acetylating)	-0.126	0.191	0.509	0.560
Acetate kinase	-0.126	0.191	0.509	0.560
Acetolactate decarboxylase	-0.126	0.191	0.509	0.560
Acetolactate synthase	-0.126	0.191	0.509	0.560
Acetyl-CoA carboxylase	-0.126	0.191	0.510	0.560
acetylglucosaminyltransferase	-0.126	0.191	0.509	0.560
Acetylglutamate kinase	-0.133	0.217	0.540	0.560
Acetylornithine transaminase	-0.133	0.217	0.539	0.560
Aconitate hydratase	-0.133	0.217	0.540	0.560
Acylphosphatase	-0.126	0.191	0.509	0.560
Adenine phosphoribosyltransferase	-0.126	0.191	0.509	0.560
Adenosylhomocysteine nucleosidase	-0.126	0.191	0.509	0.560
Adenylate cyclase	-0.121	0.201	0.548	0.560
Adenylate kinase	-0.126	0.191	0.509	0.560
Adenylosuccinate lyase	-0.126	0.191	0.509	0.560
Adenylosuccinate synthase	-0.126	0.191	0.509	0.560
ADP-ribose diphosphatase	-0.128	0.194	0.510	0.560
Agmatine deiminase	-0.121	0.201	0.548	0.560
Alanine–tRNA ligase	-0.126	0.191	0.509	0.560
Alanine dehydrogenase	-0.133	0.217	0.540	0.560
Alanine racemase	-0.126	0.191	0.509	0.560
Alanine transaminase	-0.126	0.191	0.509	0.560
Alcohol dehydrogenase	-0.127	0.192	0.509	0.560
Aldose 1-epimerase	-0.126	0.191	0.509	0.560
Alpha-amylase	-0.126	0.191	0.509	0.560
Alpha-galactosidase	-0.133	0.217	0.541	0.560
Alpha-L-fucosidase	-0.121	0.200	0.546	0.560
Alpha-mannosidase	-0.121	0.201	0.547	0.560
Alpha,alpha-phosphotrehalase	-0.133	0.217	0.540	0.560
Amidophosphoribosyltransferase	-0.126	0.191	0.509	0.560
Amino-acid N-acetyltransferase	-0.133	0.217	0.540	0.560
Aminoacyl-tRNA hydrolase	-0.126	0.191	0.509	0.560
Aminodeoxychorismate lyase	-0.126	0.191	0.509	0.560
Aminodeoxychorismate synthase	-0.126	0.191	0.509	0.560
Aminopyrimidine aminohydrolase	-0.121	0.201	0.548	0.560
Anthranilate phosphoribosyltransferase	-0.126	0.191	0.509	0.560
Anthranilate synthase	-0.126	0.191	0.509	0.560
Arginine–tRNA ligase	-0.126	0.191	0.509	0.560
Arginine decarboxylase	-0.121	0.201	0.548	0.560
Arginine deiminase	-0.133	0.217	0.540	0.560
Argininosuccinate lyase	-0.133	0.217	0.540	0.560
Argininosuccinate synthase	-0.133	0.217	0.540	0.560
Arsenate reductase (glutaredoxin)	-0.128	0.194	0.510	0.560
Asparaginase	-0.126	0.191	0.509	0.560
Asparagine–tRNA ligase	-0.126	0.191	0.509	0.560
Asparaginyl-tRNA synthase (glutamine-hydrolyzing)	-0.126	0.191	0.509	0.560
Aspartate–ammonia ligase	-0.121	0.201	0.548	0.560
Aspartate–tRNA ligase	-0.128	0.194	0.510	0.560
Aspartate-semialdehyde dehydrogenase	-0.126	0.191	0.509	0.560
Aspartate carbamoyltransferase	-0.126	0.191	0.509	0.560
Aspartate kinase	-0.126	0.191	0.509	0.560
Aspartate racemase	-0.335	1.544	0.829	0.829
ATP phosphoribosyltransferase	-0.133	0.217	0.540	0.560
Beta-fructofuranosidase	-0.126	0.191	0.509	0.560
Beta-galactosidase	-0.128	0.194	0.510	0.560
Beta-ketoacyl-[acyl-carrier-protein] synthase II	-0.126	0.191	0.509	0.560
Beta-ketoacyl-[acyl-carrier-protein] synthase III	-0.126	0.191	0.509	0.560
Beta-lactamase	-0.126	0.191	0.509	0.560
Beta-N-acetylhexosaminidase	-0.133	0.217	0.539	0.560
Biotin–[acetyl-CoA-carboxylase] ligase	-0.126	0.191	0.509	0.560
Biotin carboxylase	-0.126	0.191	0.509	0.560
Bleomycin hydrolase	-0.126	0.191	0.509	0.560
Branched-chain-amino-acid transaminase	-0.126	0.191	0.509	0.560
Calcium-transporting ATPase	-0.126	0.191	0.509	0.560
Carbamate kinase	-0.133	0.217	0.540	0.560
Carbamoyl-phosphate synthase (glutamine-hydrolyzing)	-0.126	0.191	0.509	0.560
Carbonate dehydratase	-0.126	0.191	0.509	0.560
Carboxynorspermidine decarboxylase	-0.121	0.201	0.548	0.560
Catechol 2,3-dioxygenase	-0.126	0.191	0.509	0.560
CCA tRNA nucleotidyltransferase	-0.126	0.191	0.509	0.560
CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase	-0.126	0.191	0.509	0.560
CDP-diacylglycerol–serine O-phosphatidyltransferase	-0.133	0.217	0.540	0.560
Cephalosporin-C deacetylase	-0.121	0.201	0.548	0.560
Chorismate mutase	-0.126	0.191	0.509	0.560
Chorismate synthase	-0.126	0.191	0.509	0.560
Citrate (Si)-synthase	-0.133	0.217	0.540	0.560
Coproporphyrinogen dehydrogenase	-0.126	0.191	0.509	0.560
CTP synthase (glutamine hydrolyzing)	-0.126	0.191	0.509	0.560
Cu(+) exporting ATPase	-0.126	0.191	0.509	0.560
Cystathionine beta-lyase	-0.126	0.191	0.509	0.560
Cystathionine gamma-synthase	-0.126	0.191	0.509	0.560
Cysteine–tRNA ligase	-0.126	0.191	0.509	0.560
Cysteine desulfurase	-0.126	0.191	0.509	0.560
Cysteine synthase	-0.126	0.191	0.509	0.560
Cytidine deaminase	-0.126	0.191	0.509	0.560
D-alanine–D-alanine ligase	-0.124	0.191	0.517	0.560
D-alanine–poly(phosphoribitol) ligase	-0.126	0.191	0.509	0.560
dCMP deaminase	-0.126	0.191	0.509	0.560
Deoxyribose-phosphate aldolase	-0.126	0.191	0.509	0.560
Dephospho-CoA kinase	-0.126	0.191	0.509	0.560
Dextransucrase	-0.133	0.217	0.540	0.560
Diacetyl reductase ((R)-acetoin forming)	-0.133	0.217	0.540	0.560
Diacetyl reductase ((S)-acetoin forming)	-0.121	0.201	0.547	0.560
Diacylglycerol kinase (ATP)	-0.133	0.217	0.540	0.560
Diadenylate cyclase	-0.126	0.191	0.509	0.560
Diamine N-acetyltransferase	-0.121	0.201	0.547	0.560
Diaminopimelate decarboxylase	-0.126	0.191	0.509	0.560
Diglucosyl diacylglycerol synthase (1,2-linking)	-0.133	0.217	0.540	0.560
Dihydrofolate reductase	-0.126	0.191	0.509	0.560
Dihydrofolate synthase	-0.126	0.191	0.509	0.560
Dihydrolipoyl dehydrogenase	-0.126	0.191	0.509	0.560
Dihydrolipoyllysine-residue acetyltransferase	-0.126	0.191	0.509	0.560
Dihydroneopterin aldolase	-0.126	0.191	0.509	0.560
Dihydroorotase	-0.126	0.191	0.509	0.560
Dihydroorotate dehydrogenase (NAD(+))	-0.126	0.191	0.509	0.560
Dihydroorotate oxidase (fumarate)	-0.126	0.191	0.509	0.560
Dihydropteroate synthase	-0.126	0.191	0.509	0.560
Dihydroxy-acid dehydratase	-0.126	0.191	0.509	0.560
Dimethylallyltranstransferase	-0.126	0.191	0.509	0.560
Dipeptidase E	-0.133	0.217	0.540	0.560
diphosphate specific)	-0.126	0.191	0.509	0.560
Diphosphomevalonate decarboxylase	-0.126	0.191	0.509	0.560
DNA-(apurinic or apyrimidinic site) lyase	-0.126	0.191	0.509	0.560
DNA-3-methyladenine glycosylase I	-0.126	0.191	0.509	0.560
DNA-directed DNA polymerase	-0.126	0.191	0.509	0.560
DNA-directed RNA polymerase	-0.126	0.191	0.509	0.560
DNA-formamidopyrimidine glycosylase	-0.126	0.191	0.509	0.560
DNA (cytosine-5-)-methyltransferase	-0.121	0.200	0.546	0.560
DNA helicase	-0.126	0.191	0.509	0.560
DNA ligase (NAD(+))	-0.126	0.191	0.509	0.560
DNA topoisomerase	-0.126	0.191	0.509	0.560
DNA topoisomerase (ATP-hydrolyzing)	-0.126	0.191	0.509	0.560
Dodecanoyl-[acyl-carrier-protein] hydrolase	-0.126	0.191	0.509	0.560
Dolichyl-phosphate beta-D-mannosyltransferase	-0.121	0.201	0.548	0.560
dTDP-4-dehydrorhamnose 3,5-epimerase	-0.133	0.217	0.540	0.560
dTDP-4-dehydrorhamnose reductase	-0.133	0.217	0.540	0.560
dTDP-glucose 4,6-dehydratase	-0.133	0.217	0.540	0.560
dTMP kinase	-0.126	0.191	0.509	0.560
dUTP diphosphatase	-0.126	0.191	0.509	0.560
Endopeptidase Clp	-0.126	0.191	0.509	0.560
Enoyl-[acyl-carrier-protein] reductase (NADH)	-0.126	0.191	0.509	0.560
Epoxyqueuosine reductase	-0.133	0.217	0.541	0.560
Exo-alpha-sialidase	-0.121	0.201	0.548	0.560
Exodeoxyribonuclease III	-0.126	0.191	0.509	0.560
Exodeoxyribonuclease V	-0.126	0.191	0.509	0.560
Exodeoxyribonuclease VII	-0.126	0.191	0.509	0.560
FAD synthetase	-0.126	0.191	0.509	0.560
Fe(3+)-transporting ATPase	-0.121	0.201	0.548	0.560
Ferrochelatase	-0.126	0.191	0.509	0.560
Formate–tetrahydrofolate ligase	-0.128	0.194	0.510	0.560
Formate C-acetyltransferase	-0.128	0.194	0.510	0.560
Formimidoylglutamase	-0.133	0.217	0.540	0.560
Formimidoyltetrahydrofolate cyclodeaminase	-0.133	0.217	0.540	0.560
Fructan beta-fructosidase	-0.133	0.217	0.540	0.560
Fructokinase	-0.133	0.217	0.540	0.560
Fructose-6-phosphate phosphoketolase	-0.335	1.544	0.829	0.829
Fructose-bisphosphatase	-0.133	0.217	0.541	0.560
Fructose-bisphosphate aldolase	-0.126	0.191	0.509	0.560
Galactokinase	-0.126	0.191	0.509	0.560
Galactose-6-phosphate isomerase	-0.124	0.191	0.517	0.560
Geranylgeranyl diphosphate synthase	-0.126	0.191	0.509	0.560
Glucan 1,6-alpha-glucosidase	-0.121	0.201	0.548	0.560
Glucokinase	-0.126	0.191	0.509	0.560
Glucosamine-1-phosphate N-acetyltransferase	-0.126	0.191	0.509	0.560
Glucosamine-6-phosphate deaminase	-0.126	0.191	0.509	0.560
Glucose-1-phosphate adenylyltransferase	-0.126	0.191	0.509	0.560
Glucose-1-phosphate thymidylyltransferase	-0.133	0.217	0.540	0.560
Glucose-6-phosphate dehydrogenase (NAD(P)(+))	-0.126	0.191	0.509	0.560
Glucose-6-phosphate dehydrogenase (NADP(+))	-0.126	0.191	0.509	0.560
Glucose-6-phosphate isomerase	-0.126	0.191	0.509	0.560
Glutamate–ammonia ligase	-0.126	0.191	0.509	0.560
Glutamate–cysteine ligase	-0.133	0.217	0.540	0.560
Glutamate–tRNA(Gln) ligase	-0.126	0.191	0.509	0.560
Glutamate-5-semialdehyde dehydrogenase	-0.126	0.191	0.509	0.560
Glutamate 5-kinase	-0.126	0.191	0.509	0.560
Glutamate dehydrogenase (NADP(+))	-0.128	0.194	0.510	0.560
Glutamate formimidoyltransferase	-0.133	0.217	0.540	0.560
Glutamate N-acetyltransferase	-0.133	0.217	0.540	0.560
Glutamate racemase	-0.126	0.191	0.509	0.560
Glutamine–fructose-6-phosphate transaminase (isomerizing)	-0.126	0.191	0.509	0.560
Glutaminyl-tRNA synthase (glutamine-hydrolyzing)	-0.126	0.191	0.509	0.560
Glutamyl aminopeptidase	-0.126	0.191	0.509	0.560
Glutathione-disulfide reductase	-0.126	0.191	0.509	0.560
Glutathione peroxidase	-0.126	0.191	0.509	0.560
Glyceraldehyde-3-phosphate dehydrogenase (NADP(+))	-0.133	0.217	0.541	0.560
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	-0.126	0.191	0.509	0.560
Glycerate 3-kinase	-0.126	0.191	0.509	0.560
Glycerol-3-phosphate 1-O-acyltransferase	-0.126	0.191	0.509	0.560
Glycerol-3-phosphate dehydrogenase (NAD(P)(+))	-0.126	0.191	0.509	0.560
Glycerol-3-phosphate oxidase	-0.126	0.191	0.509	0.560
Glycerol dehydrogenase	-0.133	0.217	0.541	0.560
Glycerol kinase	-0.126	0.191	0.509	0.560
Glycerone kinase	-0.121	0.201	0.548	0.560
Glycerophosphodiester phosphodiesterase	-0.126	0.191	0.509	0.560
Glycine–tRNA ligase	-0.126	0.191	0.509	0.560
Glycine hydroxymethyltransferase	-0.126	0.191	0.509	0.560
Glycogen phosphorylase	-0.128	0.194	0.510	0.560
GMP reductase	-0.126	0.191	0.509	0.560
GMP synthase (glutamine-hydrolyzing)	-0.126	0.191	0.509	0.560
GTP cyclohydrolase I	-0.126	0.191	0.509	0.560
GTP diphosphokinase	-0.126	0.191	0.509	0.560
Guanylate kinase	-0.126	0.191	0.509	0.560
H(+)-transporting two-sector ATPase	-0.127	0.192	0.509	0.560
Histidine–tRNA ligase	-0.126	0.191	0.509	0.560
Histidine ammonia-lyase	-0.133	0.217	0.540	0.560
Histidine kinase	-0.126	0.191	0.510	0.560
Histidinol-phosphatase	-0.133	0.217	0.540	0.560
Histidinol-phosphate transaminase	-0.133	0.217	0.540	0.560
Histidinol dehydrogenase	-0.133	0.217	0.540	0.560
Holo-[acyl-carrier-protein] synthase	-0.126	0.191	0.509	0.560
Homocysteine S-methyltransferase	-0.133	0.217	0.541	0.560
Homoserine dehydrogenase	-0.126	0.191	0.509	0.560
Homoserine kinase	-0.126	0.191	0.509	0.560
Homoserine O-succinyltransferase	-0.126	0.191	0.509	0.560
Hydroxyacylglutathione hydrolase	-0.335	1.544	0.829	0.829
Hydroxyethylthiazole kinase	-0.121	0.201	0.548	0.560
Hydroxymethylglutaryl-CoA reductase	-0.126	0.191	0.509	0.560
Hydroxymethylglutaryl-CoA synthase	-0.126	0.191	0.509	0.560
Hydroxymethylpyrimidine kinase	-0.121	0.201	0.548	0.560
Hypoxanthine phosphoribosyltransferase	-0.126	0.191	0.509	0.560
Imidazoleglycerol-phosphate dehydratase	-0.133	0.217	0.540	0.560
Imidazolonepropionase	-0.133	0.217	0.540	0.560
IMP cyclohydrolase	-0.126	0.191	0.509	0.560
IMP dehydrogenase	-0.126	0.191	0.509	0.560
Indole-3-glycerol-phosphate synthase	-0.126	0.191	0.509	0.560
Inorganic diphosphatase	-0.126	0.191	0.509	0.560
Inositol-phosphate phosphatase	-0.126	0.191	0.509	0.560
Iron-chelate-transporting ATPase	-0.126	0.191	0.509	0.560
Isocitrate dehydrogenase (NADP(+))	-0.133	0.217	0.540	0.560
Isoleucine–tRNA ligase	-0.126	0.191	0.509	0.560
isomerase	-0.133	0.217	0.540	0.560
Isopentenyl-diphosphate Delta-isomerase	-0.126	0.191	0.509	0.560
Kanamycin kinase	-0.133	0.217	0.540	0.560
Ketol-acid reductoisomerase (NADP(+))	-0.126	0.191	0.509	0.560
L-lactate dehydrogenase	-0.126	0.191	0.509	0.560
L-ribulose-5-phosphate 4-epimerase	-0.133	0.217	0.541	0.560
L-serine ammonia-lyase	-0.126	0.191	0.509	0.560
L-threonine aldolase	-0.335	1.544	0.829	0.829
L-threonylcarbamoyladenylate synthase	-0.126	0.191	0.509	0.560
Lactocepin	-0.134	0.217	0.538	0.560
Lactoylglutathione lyase	-0.126	0.191	0.509	0.560
Leucine–tRNA ligase	-0.126	0.191	0.509	0.560
Lipoate–protein ligase	-0.126	0.191	0.509	0.560
Lysine–tRNA ligase	-0.126	0.191	0.509	0.560
Lysine decarboxylase	-0.121	0.201	0.548	0.560
Magnesium-importing ATPase	-0.126	0.191	0.509	0.560
Malate dehydrogenase (oxaloacetate-decarboxylating)	-0.335	1.544	0.829	0.829
Maltose 6’-phosphate phosphatase	-0.126	0.191	0.509	0.560
Maltose O-acetyltransferase	-0.126	0.191	0.509	0.560
Mannose-6-phosphate isomerase	-0.126	0.191	0.509	0.560
Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	-0.121	0.201	0.548	0.560
Membrane alanyl aminopeptidase	-0.126	0.191	0.509	0.560
Methenyltetrahydrofolate cyclohydrolase	-0.126	0.191	0.509	0.560
Methionine–tRNA ligase	-0.126	0.191	0.509	0.560
Methionine adenosyltransferase	-0.126	0.191	0.509	0.560
Methionyl-tRNA formyltransferase	-0.126	0.191	0.509	0.560
Methionyl aminopeptidase	-0.126	0.191	0.509	0.560
Methylated-DNA–[protein]-cysteine S-methyltransferase	-0.126	0.191	0.509	0.560
Methylenetetrahydrofolate dehydrogenase (NADP(+))	-0.126	0.191	0.509	0.560
Methylenetetrahydrofolate reductase (NAD(P)H)	-0.126	0.191	0.509	0.560
Mevalonate kinase	-0.126	0.191	0.509	0.560
Monosaccharide-transporting ATPase	-0.126	0.191	0.509	0.560
N-acetyl-gamma-glutamyl-phosphate reductase	-0.133	0.217	0.540	0.560
N-acetyldiaminopimelate deacetylase	-0.126	0.191	0.509	0.560
N-acetylglucosamine-6-phosphate deacetylase	-0.126	0.191	0.509	0.560
N-acetylglucosaminephosphotransferase	-0.133	0.217	0.540	0.560
N-acetylneuraminate lyase	-0.126	0.191	0.509	0.560
N-acylglucosamine-6-phosphate 2-epimerase	-0.126	0.191	0.509	0.560
N-carbamoylputrescine amidase	-0.121	0.201	0.548	0.560
N(6)-L-threonylcarbamoyladenine synthase	-0.128	0.194	0.510	0.560
NAD(+) kinase	-0.126	0.191	0.509	0.560
NAD(+) synthase	-0.126	0.191	0.509	0.560
NAD(P)H dehydrogenase (quinone)	-0.133	0.217	0.540	0.560
Neopullulanase	-0.126	0.191	0.509	0.560
Nicotinamide-nucleotide amidase	-0.126	0.191	0.509	0.560
Nicotinate-nucleotide adenylyltransferase	-0.126	0.191	0.509	0.560
Nicotinate phosphoribosyltransferase	-0.126	0.191	0.509	0.560
Non-specific serine/threonine protein kinase	-0.126	0.191	0.509	0.560
Nucleoside-diphosphate kinase	-0.121	0.201	0.548	0.560
O-acetylhomoserine aminocarboxypropyltransferase	-0.126	0.191	0.509	0.560
Oligonucleotidase	-0.126	0.191	0.509	0.560
Ornithine carbamoyltransferase	-0.133	0.217	0.540	0.560
Orotate phosphoribosyltransferase	-0.126	0.191	0.509	0.560
Orotidine-5’-phosphate decarboxylase	-0.126	0.191	0.509	0.560
Pantetheine-phosphate adenylyltransferase	-0.126	0.191	0.509	0.560
Pantothenate kinase	-0.126	0.191	0.509	0.560
Peptidase Do	-0.126	0.191	0.509	0.560
Peptide-methionine (R)-S-oxide reductase	-0.126	0.191	0.509	0.560
Peptide-methionine (S)-S-oxide reductase	-0.126	0.191	0.509	0.560
Peptide chain release factor N(5)-glutamine methyltransferase	-0.126	0.191	0.509	0.560
Peptide deformylase	-0.126	0.191	0.509	0.560
Peptidoglycan glycosyltransferase	-0.126	0.191	0.509	0.560
Peptidylprolyl isomerase	-0.126	0.191	0.509	0.560
Peroxiredoxin	-0.126	0.191	0.509	0.560
Phenylalanine–tRNA ligase	-0.126	0.191	0.509	0.560
Phosphate-transporting ATPase	-0.125	0.191	0.513	0.560
Phosphate acetyltransferase	-0.126	0.191	0.509	0.560
Phosphatidate cytidylyltransferase	-0.126	0.191	0.509	0.560
Phosphatidylglycerol–membrane-oligosaccharide glycerophosphotransferase	-0.133	0.217	0.540	0.560
Phosphatidylserine decarboxylase	-0.133	0.217	0.540	0.560
Phosphinothricin acetyltransferase	-0.133	0.217	0.540	0.560
Phospho-N-acetylmuramoyl-pentapeptide-transferase	-0.126	0.191	0.509	0.560
Phosphoenolpyruvate–protein phosphotransferase	-0.126	0.191	0.509	0.560
Phosphoenolpyruvate carboxykinase (ATP)	-0.133	0.217	0.541	0.560
Phosphoenolpyruvate carboxylase	-0.126	0.191	0.509	0.560
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)	-0.126	0.191	0.509	0.560
Phosphogluconate dehydrogenase (NAD(+)-dependent, decarboxylating)	-0.126	0.191	0.509	0.560
Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating)	-0.126	0.191	0.509	0.560
Phosphoglucosamine mutase	-0.126	0.191	0.509	0.560
Phosphoglycerate dehydrogenase	-0.133	0.217	0.541	0.560
Phosphoglycerate kinase	-0.126	0.191	0.509	0.560
Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)	-0.126	0.191	0.509	0.560
Phosphoglycerate mutase (2,3-diphosphoglycerate-independent)	-0.129	0.196	0.512	0.560
Phosphoglycolate phosphatase	-0.126	0.191	0.509	0.560
Phosphoketolase	-0.335	1.544	0.829	0.829
Phosphomethylpyrimidine kinase	-0.121	0.201	0.548	0.560
Phosphomevalonate kinase	-0.126	0.191	0.509	0.560
Phosphopantothenate–cysteine ligase	-0.126	0.191	0.509	0.560
Phosphopantothenoylcysteine decarboxylase	-0.126	0.191	0.509	0.560
Phosphopentomutase	-0.126	0.191	0.509	0.560
Phosphopyruvate hydratase	-0.126	0.191	0.509	0.560
Phosphoribosyl-AMP cyclohydrolase	-0.133	0.217	0.540	0.560
Phosphoribosyl-ATP diphosphatase	-0.133	0.217	0.540	0.560
Phosphoribosylamine–glycine ligase	-0.126	0.191	0.509	0.560
Phosphoribosylaminoimidazolecarboxamide formyltransferase	-0.126	0.191	0.509	0.560
Phosphoribosylaminoimidazolesuccinocarboxamide synthase	-0.126	0.191	0.509	0.560
Phosphoribosylanthranilate isomerase	-0.126	0.191	0.509	0.560
Phosphoribosylformylglycinamidine cyclo-ligase	-0.126	0.191	0.509	0.560
Phosphoribosylformylglycinamidine synthase	-0.126	0.191	0.509	0.560
Phosphoribosylglycinamide formyltransferase	-0.126	0.191	0.509	0.560
Phosphoserine phosphatase	-0.126	0.191	0.509	0.560
Phosphoserine transaminase	-0.133	0.217	0.541	0.560
Polar-amino-acid-transporting ATPase	-0.125	0.191	0.514	0.560
Poly(glycerol-phosphate) alpha-glucosyltransferase	-0.133	0.217	0.540	0.560
Polyamine-transporting ATPase	-0.126	0.191	0.509	0.560
Polyribonucleotide nucleotidyltransferase	-0.126	0.191	0.509	0.560
Prephenate dehydratase	-0.126	0.191	0.509	0.560
Prephenate dehydrogenase	-0.126	0.191	0.509	0.560
Prepilin peptidase	-0.126	0.191	0.509	0.560
PreQ(1) synthase	-0.121	0.201	0.548	0.560
Proline–tRNA ligase	-0.126	0.191	0.509	0.560
Protein-N(pi)-phosphohistidine–sugar phosphotransferase	-0.126	0.191	0.509	0.560
Protein-serine/threonine phosphatase	-0.126	0.191	0.509	0.560
Protein-tyrosine-phosphatase	-0.128	0.194	0.510	0.560
Pullulanase	-0.129	0.198	0.514	0.560
Purine-nucleoside phosphorylase	-0.126	0.191	0.509	0.560
Pyridoxal 5’-phosphate synthase (glutamine hydrolyzing)	-0.121	0.201	0.548	0.560
Pyridoxal kinase	-0.128	0.194	0.510	0.560
Pyrimidine-nucleoside phosphorylase	-0.126	0.191	0.509	0.560
Pyroglutamyl-peptidase I	-0.121	0.201	0.548	0.560
Pyrroline-5-carboxylate reductase	-0.126	0.191	0.509	0.560
Pyruvate dehydrogenase (acetyl-transferring)	-0.126	0.191	0.509	0.560
Pyruvate kinase	-0.126	0.191	0.509	0.560
Pyruvate oxidase	-0.126	0.191	0.509	0.560
Pyruvate, phosphate dikinase	-0.133	0.217	0.540	0.560
Pyruvate, water dikinase	-0.133	0.217	0.540	0.560
Quaternary-amine-transporting ATPase	-0.335	1.544	0.829	0.829
Ribitol-5-phosphate 2-dehydrogenase	-0.121	0.201	0.548	0.560
Riboflavin kinase	-0.126	0.191	0.509	0.560
Ribonuclease H	-0.125	0.191	0.513	0.560
Ribonuclease III	-0.126	0.191	0.509	0.560
Ribonuclease M5	-0.126	0.191	0.509	0.560
Ribonuclease P	-0.126	0.191	0.509	0.560
Ribonuclease Z	-0.126	0.191	0.509	0.560
Ribonucleoside-diphosphate reductase	-0.126	0.191	0.509	0.560
Ribonucleoside-triphosphate reductase	-0.126	0.191	0.509	0.560
Ribose-5-phosphate isomerase	-0.126	0.191	0.509	0.560
Ribose-phosphate diphosphokinase	-0.126	0.191	0.509	0.560
Ribosomal-protein-alanine N-acetyltransferase	-0.128	0.194	0.510	0.560
Ribulose-phosphate 3-epimerase	-0.126	0.191	0.509	0.560
RNA helicase	-0.126	0.191	0.509	0.560
S-adenosylhomocysteine deaminase	-0.126	0.191	0.509	0.560
S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-0.126	0.191	0.509	0.560
S-methyl-5’-thioadenosine deaminase	-0.126	0.191	0.509	0.560
S-ribosylhomocysteine lyase	-0.126	0.191	0.509	0.560
Saccharopine dehydrogenase (NAD(+), L-lysine-forming)	-0.121	0.201	0.548	0.560
Selenocysteine lyase	-0.126	0.191	0.509	0.560
Serine–tRNA ligase	-0.126	0.191	0.509	0.560
Serine-type D-Ala-D-Ala carboxypeptidase	-0.128	0.194	0.510	0.560
Serine O-acetyltransferase	-0.126	0.191	0.509	0.560
Shikimate dehydrogenase	-0.126	0.191	0.509	0.560
Shikimate kinase	-0.126	0.191	0.509	0.560
Signal peptidase I	-0.128	0.194	0.510	0.560
Signal peptidase II	-0.126	0.191	0.509	0.560
Site-specific DNA-methyltransferase (adenine-specific)	-0.128	0.194	0.511	0.560
Sorbitol-6-phosphate 2-dehydrogenase	-0.335	1.544	0.829	0.829
Sortase A	-0.129	0.198	0.514	0.560
Spermidine synthase	-0.121	0.201	0.548	0.560
Starch synthase	-0.126	0.191	0.509	0.560
Succinyl-diaminopimelate desuccinylase	-0.126	0.191	0.509	0.560
Sucrose phosphorylase	-0.133	0.217	0.541	0.560
Superoxide dismutase	-0.126	0.191	0.509	0.560
Tagatose-6-phosphate kinase	-0.126	0.191	0.509	0.560
Tagatose-bisphosphate aldolase	-0.126	0.191	0.509	0.560
Tellurite methyltransferase	-0.126	0.191	0.509	0.560
Tetrahydrofolate synthase	-0.126	0.191	0.509	0.560
Thiamine-phosphate diphosphorylase	-0.121	0.201	0.548	0.560
Thiamine diphosphokinase	-0.126	0.191	0.509	0.560
Thioredoxin-disulfide reductase	-0.126	0.191	0.509	0.560
Threonine–tRNA ligase	-0.126	0.191	0.509	0.560
Threonine ammonia-lyase	-0.126	0.191	0.509	0.560
Threonine synthase	-0.126	0.191	0.509	0.560
Thymidine kinase	-0.126	0.191	0.509	0.560
Thymidylate synthase	-0.126	0.191	0.509	0.560
Trans-2-decenoyl-[acyl-carrier-protein] isomerase	-0.126	0.191	0.509	0.560
Transketolase	-0.123	0.193	0.524	0.560
Triose-phosphate isomerase	-0.126	0.191	0.509	0.560
Tripeptide aminopeptidase	-0.126	0.191	0.509	0.560
tRNA-guanine(34) transglycosylase	-0.126	0.191	0.509	0.560
tRNA (adenine(22)-N(1))-methyltransferase	-0.126	0.191	0.509	0.560
tRNA (cytidine(34)-2’-O)-methyltransferase	-0.126	0.191	0.509	0.560
tRNA (guanine(37)-N(1))-methyltransferase	-0.126	0.191	0.509	0.560
tRNA (guanine(46)-N(7))-methyltransferase	-0.126	0.191	0.509	0.560
tRNA dimethylallyltransferase	-0.126	0.191	0.509	0.560
tRNA pseudouridine(32) synthase	-0.133	0.217	0.540	0.560
tRNA pseudouridine(38-40) synthase	-0.126	0.191	0.509	0.560
tRNA pseudouridine(55) synthase	-0.126	0.191	0.509	0.560
tRNA(adenine(34)) deaminase	-0.126	0.191	0.509	0.560
tRNA(Ile)-lysidine synthetase	-0.126	0.191	0.509	0.560
Tryptophan–tRNA ligase	-0.126	0.191	0.509	0.560
Tryptophan synthase	-0.126	0.191	0.509	0.560
Type I site-specific deoxyribonuclease	-0.128	0.193	0.509	0.560
Tyrosine–tRNA ligase	-0.126	0.191	0.509	0.560
UDP-galactopyranose mutase	-0.335	1.544	0.829	0.829
UDP-glucose–hexose-1-phosphate uridylyltransferase	-0.126	0.191	0.509	0.560
UDP-glucose 4-epimerase	-0.126	0.191	0.509	0.560
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-0.126	0.191	0.509	0.560
UDP-N-acetylglucosamine diphosphorylase	-0.126	0.191	0.509	0.560
UDP-N-acetylglucosamine kinase	-0.121	0.201	0.547	0.560
UDP-N-acetylmuramate–L-alanine ligase	-0.126	0.191	0.509	0.560
UDP-N-acetylmuramate dehydrogenase	-0.126	0.191	0.509	0.560
UDP-N-acetylmuramoyl-L-alanine–D-glutamate ligase	-0.126	0.191	0.509	0.560
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase	-0.126	0.191	0.509	0.560
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–L-lysine ligase	-0.126	0.191	0.509	0.560
UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase	-0.126	0.191	0.509	0.560
UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase	-0.126	0.191	0.509	0.560
UMP kinase	-0.126	0.191	0.509	0.560
UMP/CMP kinase	-0.126	0.191	0.509	0.560
Undecaprenol kinase	-0.126	0.191	0.509	0.560
Undecaprenyl-diphosphate phosphatase	-0.126	0.191	0.509	0.560
Uracil-DNA glycosylase	-0.126	0.191	0.509	0.560
Uracil phosphoribosyltransferase	-0.126	0.191	0.509	0.560
Uridine kinase	-0.126	0.191	0.509	0.560
Urocanate hydratase	-0.133	0.217	0.540	0.560
Uroporphyrinogen decarboxylase	-0.121	0.201	0.548	0.560
UTP–glucose-1-phosphate uridylyltransferase	-0.126	0.191	0.509	0.560
Valine–pyruvate transaminase	-0.126	0.191	0.509	0.560
Valine–tRNA ligase	-0.126	0.191	0.509	0.560
Xaa-Pro aminopeptidase	-0.126	0.191	0.509	0.560
Xaa-Pro dipeptidase	-0.126	0.191	0.509	0.560
Xaa-Pro dipeptidyl-peptidase	-0.128	0.194	0.510	0.560
Xanthine phosphoribosyltransferase	-0.126	0.191	0.509	0.560
XTP/dITP diphosphatase	-0.126	0.191	0.509	0.560

# merge with tb.ra for full results table
full.res <- left_join(tb.ra, results.out, by = "description")

write.csv(full.res, "output/picrust_ec_stratefied_strepto_data_results.csv", row.names = F)

Part 2 KO Data

descriptions <- readr::read_tsv("data/PICRUST/ko_pred_metagenome_unstrat_descrip.tsv")[,1:2] %>%
  distinct()

-- Column specification --------------------------------------------------------
cols(
  .default = col_double(),
  `function` = col_character(),
  description = col_character()
)
i Use `spec()` for the full column specifications.

colnames(descriptions) <- c("func", "description")

pi.dat <- readxl::read_xlsx("data/PICRUST-Stratified/KO_strepto.xlsx")
colnames(pi.dat) <- c("func",  colnames(pi.dat)[-c(1)])

# add descriptions to dataframe
pi.dat <- left_join(pi.dat, descriptions, by="func")
pi.dat <- pi.dat[,c(1,161,3:160)]

# aggregate descriptions to get 1 description per row - unique;y defined.
pi.dat <- pi.dat %>%
  group_by(description) %>%
  summarise(across(`X1.S37.Jun172016`:`X99.D01.S37.Jun232016`,.fns = mean))

# make long format
pi.dat <- pi.dat %>%
  pivot_longer(
    cols=`X1.S37.Jun172016`:`X99.D01.S37.Jun232016`,
    names_to = "ID",
    values_to = "Abundance"
  ) %>%
  mutate(
    ID = substr(ID, 2, 99)
  )

d <- as.data.frame(dat.16s)
mydata <- full_join(pi.dat, d)

Joining, by = "ID"

Warning in class(x) <- c(setdiff(subclass, tibble_class), tibble_class): Setting
class(x) to multiple strings ("tbl_df", "tbl", ...); result will no longer be an
S4 object

mydata <- mydata %>%
  mutate(
    ID.n = as.numeric(as.factor(ID)),
    description.n = as.numeric(as.factor(description))
  ) %>%
  group_by(description)%>%
  mutate(avgA = mean(Abundance))

Abundance

# Run on all descriptions
tb.ra1 <- mydata %>%
  group_by(description) %>%
  summarise(ng = n(),
            Overall.M = mean(Abundance),
            Overall.SE = sd(Abundance)/sqrt(ng))
tb.ra2m <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(M = mean(Abundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = M)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2se <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(),SE = sd(Abundance)/sqrt(ng)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = SE)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2var <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(), VAR = var(Abundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = VAR)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2ng <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n()) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = ng)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra <- left_join(tb.ra1, tb.ra2m)

Joining, by = "description"

tb.ra <- cbind(tb.ra, tb.ra2se[,-1])
tb.ra <- cbind(tb.ra, tb.ra2var[,-1])
tb.ra <- cbind(tb.ra, tb.ra2ng[,-1]) 

colnames(tb.ra) <- c("description", "ng", "Overall Mean", "Overall SE", "Non-Tumor Mean", "Tumor Mean", "Non-Tumor SE", "Tumor SE","Non-Tumor Var", "Tumor Var", "Non-Tumor Ng", "Tumor Ng")
tb.ra <- tb.ra %>%
  arrange(desc(`Overall Mean`))
tb.ra <- tb.ra[, c("description", "Overall Mean", "Overall SE","Tumor Mean","Tumor Var", "Tumor SE","Tumor Ng", "Non-Tumor Mean","Non-Tumor Var", "Non-Tumor SE", "Non-Tumor Ng")]

# compute t-test
tb.ra <- tb.ra %>%
  mutate(
    SEpooled = sqrt(`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`),
    t = (`Tumor Mean` - `Non-Tumor Mean`)/(SEpooled),
    df = ((`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`)**2)/(((`Tumor Var`/`Tumor Ng`)**2)/(`Tumor Ng`-1) + ((`Non-Tumor Var`/`Non-Tumor Ng`)**2)/(`Non-Tumor Ng`-1)),
    p = pt(q = abs(t), df=df, lower.tail = F)*2,
    fdr_p = p.adjust(p, method="fdr")
  )



kable(tb.ra, format="html", digits=5, caption="Stratefied KO Data - Streptococcus sanguinis : Average Abundance of Each Description (sorted in descending order)") %>%
  kable_styling(full_width = T) %>%
  scroll_box(width = "100%", height="600px")

Stratefied KO Data - Streptococcus sanguinis : Average Abundance of Each Description (sorted in descending order)

description	Overall Mean	Overall SE	Tumor Mean	Tumor Var	Tumor SE	Tumor Ng	Non-Tumor Mean	Non-Tumor Var	Non-Tumor SE	Non-Tumor Ng	SEpooled	t	df	p	fdr_p
ABC-2.A; ABC-2 type transport system ATP-binding protein	27.22042	2.52951	25.22369	761.72886	3.42329	65	28.61599	1190.52333	3.57789	93	4.95179	-0.68506	153.10	0.49434	0.55070
ABC-2.P; ABC-2 type transport system permease protein	27.22042	2.52951	25.22369	761.72886	3.42329	65	28.61599	1190.52333	3.57789	93	4.95179	-0.68506	153.10	0.49434	0.55070
SPP; sucrose-6-phosphatase [EC:3.1.3.24]	24.14849	2.25083	22.36767	616.35075	3.07934	65	25.39315	933.44165	3.16812	93	4.41807	-0.68480	152.41	0.49451	0.55070
ABC.CD.A; putative ABC transport system ATP-binding protein	23.31104	2.16496	21.60594	551.49891	2.91283	65	24.50277	876.62701	3.07019	93	4.23210	-0.68449	153.45	0.49470	0.55070
ABC.CD.P; putative ABC transport system permease protein	20.24037	1.88374	18.75094	428.00923	2.56608	65	21.28137	656.36608	2.65663	93	3.69357	-0.68509	152.69	0.49433	0.55070
K07052; uncharacterized protein	17.86949	1.65925	16.56325	322.76489	2.22837	65	18.78244	515.74316	2.35492	93	3.24210	-0.68449	153.55	0.49470	0.55070
K07491; putative transposase	17.27962	1.69696	16.06512	283.92047	2.08998	65	18.12847	577.16266	2.49119	93	3.25178	-0.63453	155.99	0.52666	0.55070
ABCB-BAC; ATP-binding cassette, subfamily B, bacterial	17.16844	1.60995	15.89492	322.47469	2.22736	65	18.05853	472.59016	2.25424	93	3.16903	-0.68273	151.61	0.49582	0.55070
mutT, NUDT15, MTH2; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]	15.63121	1.47713	14.46589	276.44703	2.06229	65	16.44568	394.37041	2.05926	93	2.91437	-0.67932	150.89	0.49798	0.55070
oppA, mppA; oligopeptide transport system substrate-binding protein	13.12392	1.23949	12.18479	163.72791	1.58710	65	13.78029	299.28981	1.79393	93	2.39522	-0.66612	155.47	0.50632	0.55070
hemE, UROD; uroporphyrinogen decarboxylase [EC:4.1.1.37]	11.51975	1.13130	10.71008	126.18687	1.39332	65	12.08565	256.51674	1.66080	93	2.16785	-0.63453	155.99	0.52666	0.55070
licD; lipopolysaccharide cholinephosphotransferase [EC:2.7.8.-]	11.51975	1.13130	10.71008	126.18687	1.39332	65	12.08565	256.51674	1.66080	93	2.16785	-0.63453	155.99	0.52666	0.55070
NEU1; sialidase-1 [EC:3.2.1.18]	11.51975	1.13130	10.71008	126.18687	1.39332	65	12.08565	256.51674	1.66080	93	2.16785	-0.63453	155.99	0.52666	0.55070
thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]	11.51975	1.13130	10.71008	126.18687	1.39332	65	12.08565	256.51674	1.66080	93	2.16785	-0.63453	155.99	0.52666	0.55070
thiM; hydroxyethylthiazole kinase [EC:2.7.1.50]	11.51975	1.13130	10.71008	126.18687	1.39332	65	12.08565	256.51674	1.66080	93	2.16785	-0.63453	155.99	0.52666	0.55070
ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:3.6.3.21]	11.23806	1.04586	10.42313	123.83431	1.38027	65	11.80763	207.98515	1.49546	93	2.03508	-0.68032	154.42	0.49732	0.55070
ABC.PA.P; polar amino acid transport system permease protein	11.23806	1.04586	10.42313	123.83431	1.38027	65	11.80763	207.98515	1.49546	93	2.03508	-0.68032	154.42	0.49732	0.55070
ABC.PA.S; polar amino acid transport system substrate-binding protein	11.23806	1.04586	10.42313	123.83431	1.38027	65	11.80763	207.98515	1.49546	93	2.03508	-0.68032	154.42	0.49732	0.55070
K07729; putative transcriptional regulator	10.53828	0.98946	9.75583	122.22980	1.37130	65	11.08515	178.21059	1.38428	93	1.94851	-0.68223	151.47	0.49614	0.55070
ecfT; energy-coupling factor transport system permease protein	9.70336	0.90115	8.99614	93.94865	1.20223	65	10.19765	153.00319	1.28265	93	1.75800	-0.68345	153.90	0.49535	0.55070
gpmB; probable phosphoglycerate mutase [EC:5.4.2.12]	9.00231	0.85848	8.32782	94.85856	1.20804	65	9.47373	132.18135	1.19218	93	1.69725	-0.67516	150.24	0.50061	0.55070
E5.3.1.26, lacA, lacB; galactose-6-phosphate isomerase [EC:5.3.1.26]	8.51855	0.79469	7.90281	70.30952	1.04004	65	8.94890	120.91553	1.14025	93	1.54332	-0.67782	154.77	0.49890	0.55070
lacI, galR; LacI family transcriptional regulator	8.16866	0.75885	7.56916	68.54934	1.02694	65	8.58766	107.14834	1.07337	93	1.48551	-0.68563	153.10	0.49399	0.55070
argR, ahrC; transcriptional regulator of arginine metabolism	8.16613	0.75885	7.56711	68.55560	1.02699	65	8.58480	107.14710	1.07337	93	1.48554	-0.68506	153.10	0.49434	0.55070
PTS-Man-EIIB, manX; PTS system, mannose-specific IIB component [EC:2.7.1.191]	8.16613	0.75885	7.56711	68.55560	1.02699	65	8.58480	107.14710	1.07337	93	1.48554	-0.68506	153.10	0.49434	0.55070
PTS-Man-EIIC, manY; PTS system, mannose-specific IIC component	8.16613	0.75885	7.56711	68.55560	1.02699	65	8.58480	107.14710	1.07337	93	1.48554	-0.68506	153.10	0.49434	0.55070
rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]	8.16613	0.75885	7.56711	68.55560	1.02699	65	8.58480	107.14710	1.07337	93	1.48554	-0.68506	153.10	0.49434	0.55070
agrA, blpR, fsrA; two-component system, LytTR family, response regulator AgrA	7.32994	0.69443	6.80640	50.95990	0.88544	65	7.69586	94.24634	1.00668	93	1.34067	-0.66344	155.57	0.50803	0.55070
ABCC-BAC; ATP-binding cassette, subfamily C, bacterial	6.98258	0.64883	6.47480	48.14398	0.86063	65	7.33748	79.70847	0.92579	93	1.26402	-0.68249	154.19	0.49595	0.55070
ecfA2; energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-]	6.98258	0.64883	6.47480	48.14398	0.86063	65	7.33748	79.70847	0.92579	93	1.26402	-0.68249	154.19	0.49595	0.55070
ABC.PE.S; peptide/nickel transport system substrate-binding protein	6.98005	0.64885	6.47275	48.14762	0.86066	65	7.33462	79.71352	0.92582	93	1.26407	-0.68182	154.19	0.49638	0.55070
pstB; phosphate transport system ATP-binding protein [EC:3.6.3.27]	6.98005	0.64885	6.47275	48.14762	0.86066	65	7.33462	79.71352	0.92582	93	1.26407	-0.68182	154.19	0.49638	0.55070
ABC.FEV.P; iron complex transport system permease protein	6.97878	0.64886	6.47172	48.14964	0.86068	65	7.33318	79.71661	0.92583	93	1.26409	-0.68148	154.19	0.49659	0.55070
hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]	6.62763	0.62059	6.13705	47.65345	0.85623	65	6.97051	70.40314	0.87007	93	1.22072	-0.68276	151.81	0.49580	0.55070
E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	6.20647	0.58424	5.76146	36.76504	0.75207	65	6.51750	66.21996	0.84383	93	1.13034	-0.66887	155.32	0.50457	0.55070
ABC.GLN1.P; putative glutamine transport system permease protein	5.83024	0.54205	5.40288	34.98266	0.73362	65	6.12892	54.66741	0.76670	93	1.06114	-0.68421	153.10	0.49487	0.55070
yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]	5.79524	0.54524	5.37942	32.02514	0.70192	65	6.08587	57.67286	0.78749	93	1.05491	-0.66968	155.32	0.50405	0.55070
ABC.MS.S; multiple sugar transport system substrate-binding protein	5.79397	0.54526	5.37839	32.02572	0.70193	65	6.08444	57.67871	0.78753	93	1.05494	-0.66928	155.32	0.50431	0.55070
agrC, blpH, fsrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]	5.79397	0.54526	5.37839	32.02572	0.70193	65	6.08444	57.67871	0.78753	93	1.05494	-0.66928	155.32	0.50431	0.55070
adh2; alcohol dehydrogenase [EC:1.1.1.-]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
afuA, fbpA; iron(III) transport system substrate-binding protein	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
afuB, fbpB; iron(III) transport system permease protein	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
afuC, fbpC; iron(III) transport system ATP-binding protein [EC:3.6.3.30]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
aguA; agmatine deiminase [EC:3.5.3.12]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
aguB; N-carbamoylputrescine amidase [EC:3.5.1.53]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
asnA; aspartate–ammonia ligase [EC:6.3.1.1]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
cah; cephalosporin-C deacetylase [EC:3.1.1.41]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
cpoA; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-galactosyltransferase [EC:2.4.1.-]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
DAK, TKFC; triose/dihydroxyacetone kinase / FAD-AMP lyase (cyclizing) [EC:2.7.1.28 2.7.1.29 4.6.1.15]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
dexB; glucan 1,6-alpha-glucosidase [EC:3.2.1.70]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
dhaK; phosphoenolpyruvate—glycerone phosphotransferase subunit DhaK [EC:2.7.1.121]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
doc; death on curing protein	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
E2.7.13.3; histidine kinase [EC:2.7.13.3]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
E3.2.1.96; mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase [EC:3.2.1.96]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
E4.1.1.18, ldcC, cadA; lysine decarboxylase [EC:4.1.1.18]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
E4.1.1.19; arginine decarboxylase [EC:4.1.1.19]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
E4.6.1.1B, cyaB; adenylate cyclase, class 2 [EC:4.6.1.1]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
K06915; uncharacterized protein	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
K07133; uncharacterized protein	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
mmr; MFS transporter, DHA2 family, methylenomycin A resistance protein	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
nspC; carboxynorspermidine decarboxylase [EC:4.1.1.96]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
pcp; pyroglutamyl-peptidase [EC:3.4.19.3]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
pdxS, pdx1; pyridoxal 5’-phosphate synthase pdxS subunit [EC:4.3.3.6]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
pdxT, pdx2; 5’-phosphate synthase pdxT subunit [EC:4.3.3.6]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
slo; thiol-activated cytolysin	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
speE, SRM; spermidine synthase [EC:2.5.1.16]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
tarJ; ribitol-5-phosphate 2-dehydrogenase (NADP+) [EC:1.1.1.405]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
TC.AAT; amino acid transporter, AAT family	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
TC.CPA1; monovalent cation:H+ antiporter, CPA1 family	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
TC.NSS; neurotransmitter:Na+ symporter, NSS family	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
TC.POT; proton-dependent oligopeptide transporter, POT family	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
tenA; thiaminase (transcriptional activator TenA) [EC:3.5.99.2]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
xerD; integrase/recombinase XerD	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
yefM; antitoxin YefM	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
ykoE; energy-coupling factor transport system substrate-specific component	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
ytmI; uncharacterized N-acetyltransferase [EC:2.3.1.-]	5.75987	0.56565	5.35504	31.54672	0.69666	65	6.04282	64.12918	0.83040	93	1.08393	-0.63453	155.99	0.52666	0.55070
ssb; single-strand DNA-binding protein	5.44535	0.50590	5.04576	30.46705	0.68463	65	5.72463	47.62128	0.71558	93	0.99034	-0.68549	153.10	0.49407	0.55070
ABC.FEV.A; iron complex transport system ATP-binding protein [EC:3.6.3.34]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
ABC.SS.P; simple sugar transport system permease protein	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
acpP; acyl carrier protein	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
ccdA; cytochrome c-type biogenesis protein	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
crcB, FEX; fluoride exporter	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
E4.3.1.17, sdaA, sdaB, tdcG; L-serine dehydratase [EC:4.3.1.17]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
galE, GALE; UDP-glucose 4-epimerase [EC:5.1.3.2]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
glgC; glucose-1-phosphate adenylyltransferase [EC:2.7.7.27]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
GLPF; glycerol uptake facilitator protein	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
iscS, NFS1; cysteine desulfurase [EC:2.8.1.7]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
PDF, def; peptide deformylase [EC:3.5.1.88]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
PTS-Man-EIID, manZ; PTS system, mannose-specific IID component	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
rnj; ribonuclease J [EC:3.1.-.-]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
rtpR; ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
secA; preprotein translocase subunit SecA	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
secY; preprotein translocase subunit SecY	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
trkA, ktrA; trk system potassium uptake protein	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
trkH, trkG, ktrB; trk system potassium uptake protein	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
trpB; tryptophan synthase beta chain [EC:4.2.1.20]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
trpF; phosphoribosylanthranilate isomerase [EC:5.3.1.24]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9]	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
znuA; zinc transport system substrate-binding protein	5.44408	0.50590	5.04474	30.46915	0.68466	65	5.72320	47.62093	0.71558	93	0.99036	-0.68506	153.10	0.49434	0.55070
E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	5.44282	0.50591	5.04371	30.47140	0.68468	65	5.72176	47.62097	0.71558	93	0.99038	-0.68464	153.10	0.49461	0.55070
K07010; putative glutamine amidotransferase	5.44282	0.50591	5.04371	30.47140	0.68468	65	5.72176	47.62097	0.71558	93	0.99038	-0.68464	153.10	0.49461	0.55070
spxA; regulatory protein spx	5.44282	0.50591	5.04371	30.47140	0.68468	65	5.72176	47.62097	0.71558	93	0.99038	-0.68464	153.10	0.49461	0.55070
E3.2.1.86B, bglA; 6-phospho-beta-glucosidase [EC:3.2.1.86]	5.09419	0.48981	4.71109	31.22347	0.69308	65	5.36196	42.79143	0.67832	93	0.96979	-0.67115	149.75	0.50316	0.55070
K07025; putative hydrolase of the HAD superfamily	5.09419	0.48981	4.71109	31.22347	0.69308	65	5.36196	42.79143	0.67832	93	0.96979	-0.67115	149.75	0.50316	0.55070
pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3]	5.09419	0.48981	4.71109	31.22347	0.69308	65	5.36196	42.79143	0.67832	93	0.96979	-0.67115	149.75	0.50316	0.55070
pulA; pullulanase [EC:3.2.1.41]	5.09293	0.48980	4.71006	31.22724	0.69312	65	5.36052	42.78526	0.67827	93	0.96978	-0.67073	149.74	0.50343	0.55070
DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]	4.61549	0.45235	4.29018	20.19631	0.55742	65	4.84286	40.99446	0.66393	93	0.86690	-0.63753	155.99	0.52471	0.55070
FUCA; alpha-L-fucosidase [EC:3.2.1.51]	4.61549	0.45235	4.29018	20.19631	0.55742	65	4.84286	40.99446	0.66393	93	0.86690	-0.63753	155.99	0.52471	0.55070
aqpZ; aquaporin Z	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
butA, budC; meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.- 1.1.1.76 1.1.1.304]	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
comA; ATP-binding cassette, subfamily C, bacterial, competence factor transporting protein [EC:3.4.22.-]	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
comB; competence factor transport accessory protein ComB	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
K07485; transposase	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
K09704; uncharacterized protein	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
lctO; L-lactate oxidase [EC:1.1.3.2]	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
MAN2C1; alpha-mannosidase [EC:3.2.1.24]	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
pbuX; xanthine permease	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
pezA; HTH-type transcriptional regulator / antitoxin PezA	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
pezT; UDP-N-acetylglucosamine kinase [EC:2.7.1.176]	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
PTS-Gat-EIIA, gatA, sgcA; PTS system, galactitol-specific IIA component [EC:2.7.1.200]	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
PTS-Gat-EIIB, gatB, sgcB; PTS system, galactitol-specific IIB component [EC:2.7.1.200]	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
PTS-Gat-EIIC, gatC, sgcC; PTS system, galactitol-specific IIC component	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
queH; epoxyqueuosine reductase [EC:1.17.99.6]	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
relE, stbE; mRNA interferase RelE/StbE	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
speG, SAT; diamine N-acetyltransferase [EC:2.3.1.57]	4.61170	0.45243	4.28711	20.19249	0.55736	65	4.83856	41.01685	0.66411	93	0.86700	-0.63604	155.99	0.52568	0.55070
ABC.MS.P; multiple sugar transport system permease protein	4.56080	0.42576	4.23145	20.18011	0.55719	65	4.79098	34.70837	0.61091	93	0.82684	-0.67671	154.77	0.49960	0.55070
ABC.MS.P1; multiple sugar transport system permease protein	4.56080	0.42576	4.23145	20.18011	0.55719	65	4.79098	34.70837	0.61091	93	0.82684	-0.67671	154.77	0.49960	0.55070
tcyM; L-cystine transport system permease protein	4.56080	0.42576	4.23145	20.18011	0.55719	65	4.79098	34.70837	0.61091	93	0.82684	-0.67671	154.77	0.49960	0.55070
ABC.X4.A; putative ABC transport system ATP-binding protein	4.25927	0.39735	3.95141	17.57738	0.52002	65	4.47445	30.22888	0.57012	93	0.77166	-0.67782	154.77	0.49890	0.55070
ABC.X4.P; putative ABC transport system permease protein	4.25927	0.39735	3.95141	17.57738	0.52002	65	4.47445	30.22888	0.57012	93	0.77166	-0.67782	154.77	0.49890	0.55070
yesN; two-component system, response regulator YesN	4.25927	0.39735	3.95141	17.57738	0.52002	65	4.47445	30.22888	0.57012	93	0.77166	-0.67782	154.77	0.49890	0.55070
ABC.FEV.S; iron complex transport system substrate-binding protein	4.25801	0.39736	3.95038	17.57818	0.52003	65	4.47302	30.23167	0.57015	93	0.77169	-0.67726	154.77	0.49925	0.55070
ABC.X4.S; putative ABC transport system substrate-binding protein	4.25801	0.39736	3.95038	17.57818	0.52003	65	4.47302	30.23167	0.57015	93	0.77169	-0.67726	154.77	0.49925	0.55070
comE; two-component system, LytTR family, response regulator ComE	4.25801	0.39736	3.95038	17.57818	0.52003	65	4.47302	30.23167	0.57015	93	0.77169	-0.67726	154.77	0.49925	0.55070
comX1_2; competence protein ComX	4.25801	0.39736	3.95038	17.57818	0.52003	65	4.47302	30.23167	0.57015	93	0.77169	-0.67726	154.77	0.49925	0.55070
ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]	4.25801	0.39736	3.95038	17.57818	0.52003	65	4.47302	30.23167	0.57015	93	0.77169	-0.67726	154.77	0.49925	0.55070
ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein	4.25801	0.39736	3.95038	17.57818	0.52003	65	4.47302	30.23167	0.57015	93	0.77169	-0.67726	154.77	0.49925	0.55070
K07007; uncharacterized protein	4.25801	0.39736	3.95038	17.57818	0.52003	65	4.47302	30.23167	0.57015	93	0.77169	-0.67726	154.77	0.49925	0.55070
K17318, lplA; putative aldouronate transport system substrate-binding protein	4.25801	0.39736	3.95038	17.57818	0.52003	65	4.47302	30.23167	0.57015	93	0.77169	-0.67726	154.77	0.49925	0.55070
lplB; putative aldouronate transport system permease protein	4.25801	0.39736	3.95038	17.57818	0.52003	65	4.47302	30.23167	0.57015	93	0.77169	-0.67726	154.77	0.49925	0.55070
lplC; putative aldouronate transport system permease protein	4.25801	0.39736	3.95038	17.57818	0.52003	65	4.47302	30.23167	0.57015	93	0.77169	-0.67726	154.77	0.49925	0.55070
metI; D-methionine transport system permease protein	4.25801	0.39736	3.95038	17.57818	0.52003	65	4.47302	30.23167	0.57015	93	0.77169	-0.67726	154.77	0.49925	0.55070
padR; PadR family transcriptional regulator, regulatory protein PadR	4.25801	0.39736	3.95038	17.57818	0.52003	65	4.47302	30.23167	0.57015	93	0.77169	-0.67726	154.77	0.49925	0.55070
rnhB; ribonuclease HII [EC:3.1.26.4]	4.25801	0.39736	3.95038	17.57818	0.52003	65	4.47302	30.23167	0.57015	93	0.77169	-0.67726	154.77	0.49925	0.55070
zmpB; zinc metalloprotease ZmpB [EC:3.4.24.-]	4.25801	0.39736	3.95038	17.57818	0.52003	65	4.47302	30.23167	0.57015	93	0.77169	-0.67726	154.77	0.49925	0.55070
hsdM; type I restriction enzyme M protein [EC:2.1.1.72]	4.18456	0.39565	3.87287	19.83949	0.55247	65	4.40240	28.28947	0.55153	93	0.78065	-0.67833	150.88	0.49860	0.55070
hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]	4.18456	0.39565	3.87287	19.83949	0.55247	65	4.40240	28.28947	0.55153	93	0.78065	-0.67833	150.88	0.49860	0.55070
RP-L33, MRPL33, rpmG; large subunit ribosomal protein L33	3.90938	0.36929	3.61775	17.27501	0.51553	65	4.11321	24.65235	0.51486	93	0.72859	-0.68002	150.90	0.49753	0.55070
ABC.CD.TX; HlyD family secretion protein	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
ARSC1, arsC; arsenate reductase [EC:1.20.4.1]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
aspS; aspartyl-tRNA synthetase [EC:6.1.1.12]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
E1.4.1.4, gdhA; glutamate dehydrogenase (NADP+) [EC:1.4.1.4]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
E3.1.3.48; protein-tyrosine phosphatase [EC:3.1.3.48]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
fhs; formate–tetrahydrofolate ligase [EC:6.3.4.3]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
ftsK, spoIIIE; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
KAE1, tsaD, QRI7; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
lacR; DeoR family transcriptional regulator, lactose phosphotransferase system repressor	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
lepB; signal peptidase I [EC:3.4.21.89]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
nrdI; protein involved in ribonucleotide reduction	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
nudF; ADP-ribose pyrophosphatase [EC:3.6.1.13]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
pdxK, pdxY; pyridoxine kinase [EC:2.7.1.35]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
pepX; X-Pro dipeptidyl-peptidase [EC:3.4.14.11]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
rimI; [ribosomal protein S18]-alanine N-acetyltransferase [EC:2.3.1.266]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
rimJ; [ribosomal protein S5]-alanine N-acetyltransferase [EC:2.3.1.267]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
sufB; Fe-S cluster assembly protein SufB	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
thiJ; protein deglycase [EC:3.5.1.124]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
trxA; thioredoxin 1	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]	3.90812	0.36928	3.61673	17.27734	0.51556	65	4.11178	24.64894	0.51482	93	0.72859	-0.67946	150.90	0.49789	0.55070
E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]	3.90685	0.36928	3.61570	17.27980	0.51560	65	4.11034	24.64592	0.51479	93	0.72860	-0.67890	150.89	0.49824	0.55070
E2.3.1.54, pflD; formate C-acetyltransferase [EC:2.3.1.54]	3.90685	0.36928	3.61570	17.27980	0.51560	65	4.11034	24.64592	0.51479	93	0.72860	-0.67890	150.89	0.49824	0.55070
msmX, msmK, malK, sugC, ggtA, msiK; multiple sugar transport system ATP-binding protein	3.90685	0.36928	3.61570	17.27980	0.51560	65	4.11034	24.64592	0.51479	93	0.72860	-0.67890	150.89	0.49824	0.55070
pflA, pflC, pflE; pyruvate formate lyase activating enzyme [EC:1.97.1.4]	3.90685	0.36928	3.61570	17.27980	0.51560	65	4.11034	24.64592	0.51479	93	0.72860	-0.67890	150.89	0.49824	0.55070
srtA; sortase A [EC:3.4.22.70]	3.90685	0.36928	3.61570	17.27980	0.51560	65	4.11034	24.64592	0.51479	93	0.72860	-0.67890	150.89	0.49824	0.55070
PTS-Cel-EIIC, celB, chbC; PTS system, cellobiose-specific IIC component	3.55443	0.37434	3.28000	19.29975	0.54490	65	3.74624	24.26795	0.51083	93	0.74690	-0.62423	146.96	0.53345	0.55070
pps, ppsA; pyruvate, water dikinase [EC:2.7.9.2]	3.23475	0.34040	2.98462	15.93997	0.49521	65	3.40958	20.07809	0.46464	93	0.67906	-0.62581	147.02	0.53241	0.55070
ABC.GLN1.A; putative glutamine transport system ATP-binding protein [EC:3.6.3.-]	2.91512	0.27103	2.70144	8.74566	0.36681	65	3.06446	13.66685	0.38335	93	0.53057	-0.68421	153.10	0.49487	0.55070
ABC.GLN1.S; putative glutamine transport system substrate-binding protein	2.91512	0.27103	2.70144	8.74566	0.36681	65	3.06446	13.66685	0.38335	93	0.53057	-0.68421	153.10	0.49487	0.55070
accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]	2.91512	0.27103	2.70144	8.74566	0.36681	65	3.06446	13.66685	0.38335	93	0.53057	-0.68421	153.10	0.49487	0.55070
dhaL; phosphoenolpyruvate—glycerone phosphotransferase subunit DhaL [EC:2.7.1.121]	2.91512	0.27103	2.70144	8.74566	0.36681	65	3.06446	13.66685	0.38335	93	0.53057	-0.68421	153.10	0.49487	0.55070
PTS-Ula-EIIB, ulaB, sgaB; PTS system, ascorbate-specific IIB component [EC:2.7.1.194]	2.91512	0.27103	2.70144	8.74566	0.36681	65	3.06446	13.66685	0.38335	93	0.53057	-0.68421	153.10	0.49487	0.55070
PTS-Ula-EIIC, ulaA, sgaT; PTS system, ascorbate-specific IIC component	2.91512	0.27103	2.70144	8.74566	0.36681	65	3.06446	13.66685	0.38335	93	0.53057	-0.68421	153.10	0.49487	0.55070
TC.AGCS; alanine or glycine:cation symporter, AGCS family	2.91512	0.27103	2.70144	8.74566	0.36681	65	3.06446	13.66685	0.38335	93	0.53057	-0.68421	153.10	0.49487	0.55070
tcyK; L-cystine transport system substrate-binding protein	2.91512	0.27103	2.70144	8.74566	0.36681	65	3.06446	13.66685	0.38335	93	0.53057	-0.68421	153.10	0.49487	0.55070
tcyL; L-cystine transport system permease protein	2.91512	0.27103	2.70144	8.74566	0.36681	65	3.06446	13.66685	0.38335	93	0.53057	-0.68421	153.10	0.49487	0.55070
tcyN; L-cystine transport system ATP-binding protein [EC:3.6.3.-]	2.91512	0.27103	2.70144	8.74566	0.36681	65	3.06446	13.66685	0.38335	93	0.53057	-0.68421	153.10	0.49487	0.55070
ABC-2.CYL.A, cylA; multidrug/hemolysin transport system ATP-binding protein	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
ABC-2.CYL.P, cylB; multidrug/hemolysin transport system permease protein	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
clpC; ATP-dependent Clp protease ATP-binding subunit ClpC	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
copA, ATP7; Cu+-exporting ATPase [EC:3.6.3.54]	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
ctpE; cation-transporting P-type ATPase E [EC:3.6.3.-]	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
ecfA1; energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-]	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
endA; DNA-entry nuclease	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
GPI, pgi; glucose-6-phosphate isomerase [EC:5.3.1.9]	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
lacC; tagatose 6-phosphate kinase [EC:2.7.1.144]	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40]	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
LDH, ldh; L-lactate dehydrogenase [EC:1.1.1.27]	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
pnuC; nicotinamide mononucleotide transporter	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9]	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
udk, UCK; uridine kinase [EC:2.7.1.48]	2.72331	0.25295	2.52339	7.61627	0.34231	65	2.86303	11.90550	0.35779	93	0.49517	-0.68591	153.11	0.49381	0.55070
aadK; aminoglycoside 6-adenylyltransferase [EC:2.7.7.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ABC.SS.A; simple sugar transport system ATP-binding protein [EC:3.6.3.17]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ABCF3; ATP-binding cassette, subfamily F, member 3	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
accB, bccP; acetyl-CoA carboxylase biotin carboxyl carrier protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ackA; acetate kinase [EC:2.7.2.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
acm; lysozyme	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
acuB; acetoin utilization protein AcuB	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
acyP; acylphosphatase [EC:3.6.1.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
addA; ATP-dependent helicase/nuclease subunit A [EC:3.1.-.- 3.6.4.12]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
addB; ATP-dependent helicase/nuclease subunit B [EC:3.1.-.- 3.6.4.12]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
adk, AK; adenylate kinase [EC:2.7.4.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
agaS; tagatose-6-phosphate ketose/aldose isomerase [EC:5.-.-.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
alr; alanine racemase [EC:5.1.1.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
alsD, budA, aldC; acetolactate decarboxylase [EC:4.1.1.5]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ampC; beta-lactamase class C [EC:3.5.2.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ampS, pepS, ampT; aminopeptidase [EC:3.4.11.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
AMY, amyA, malS; alpha-amylase [EC:3.2.1.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
apbE; FAD:protein FMN transferase [EC:2.7.1.180]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
APRT, apt; adenine phosphoribosyltransferase [EC:2.4.2.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
AROA1, aroA; chorismate mutase [EC:5.4.99.5]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
aroB; 3-dehydroquinate synthase [EC:4.2.3.4]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
aroC; chorismate synthase [EC:4.2.3.5]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
aroD; 3-dehydroquinate dehydratase I [EC:4.2.1.10]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
aroE; shikimate dehydrogenase [EC:1.1.1.25]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
asp1; accessory secretory protein Asp1	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
asp2; accessory secretory protein Asp2	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
asp3; accessory secretory protein Asp3	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ATPF0A, atpB; F-type H+-transporting ATPase subunit a	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ATPF0B, atpF; F-type H+-transporting ATPase subunit b	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ATPF0C, atpE; F-type H+-transporting ATPase subunit c	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ATPF1A, atpA; F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ATPF1B, atpD; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ATPF1D, atpH; F-type H+-transporting ATPase subunit delta	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ATPF1E, atpC; F-type H+-transporting ATPase subunit epsilon	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ATPF1G, atpG; F-type H+-transporting ATPase subunit gamma	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
bgaB, lacA; beta-galactosidase [EC:3.2.1.23]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
bioY; biotin transport system substrate-specific component	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
birA; BirA family transcriptional regulator, biotin operon repressor / biotin—[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
BLMH, pepC; bleomycin hydrolase [EC:3.4.22.40]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
bmpA, bmpB, tmpC; basic membrane protein A and related proteins	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
capA, pgsA; gamma-polyglutamate biosynthesis protein CapA	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
catE; catechol 2,3-dioxygenase [EC:1.13.11.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
cbf, cbf1; 3’-5’ exoribonuclease [EC:3.1.-.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
cdd, CDA; cytidine deaminase [EC:3.5.4.5]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ciaR; two-component system, OmpR family, response regulator CiaR	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
cidA; holin-like protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
clpE; ATP-dependent Clp protease ATP-binding subunit ClpE	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
clpL; ATP-dependent Clp protease ATP-binding subunit ClpL	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
clpX, CLPX; ATP-dependent Clp protease ATP-binding subunit ClpX	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
clsA_B; cardiolipin synthase A/B [EC:2.7.8.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
cmk; CMP/dCMP kinase [EC:2.7.4.25]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
coaA; type I pantothenate kinase [EC:2.7.1.33]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
coaE; dephospho-CoA kinase [EC:2.7.1.24]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
codY; transcriptional pleiotropic repressor	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
coiA; competence protein CoiA	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
comC; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
comD; two-component system, LytTR family, sensor histidine kinase ComD [EC:2.7.13.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
comEA; competence protein ComEA	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
comEB; dCMP deaminase [EC:3.5.4.12]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
comEC; competence protein ComEC	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
comFA; competence protein ComFA	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
comFC; competence protein ComFC	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
comGA; competence protein ComGA	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
comGB; competence protein ComGB	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
comGC; competence protein ComGC	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
comGD; competence protein ComGD	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
comGF; competence protein ComGF	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
corA; magnesium transporter	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
cshB; ATP-dependent RNA helicase CshB [EC:3.6.4.13]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ctsR; transcriptional regulator of stress and heat shock response	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
cutC; copper homeostasis protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
cycB, ganO; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
cynT, can; carbonic anhydrase [EC:4.2.1.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
cysE; serine O-acetyltransferase [EC:2.3.1.30]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
cysK; cysteine synthase A [EC:2.5.1.47]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
czcD, zitB; cobalt-zinc-cadmium efflux system protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dacA; diadenylate cyclase [EC:2.7.7.85]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dacC, dacA, dacD; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dapD; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [EC:2.3.1.117]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dapL; N-acetyldiaminopimelate deacetylase [EC:3.5.1.47]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
deaD, cshA; ATP-dependent RNA helicase DeaD [EC:3.6.4.13]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
degP, htrA; serine protease Do [EC:3.4.21.107]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
deoB; phosphopentomutase [EC:5.4.2.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
deoC, DERA; deoxyribose-phosphate aldolase [EC:4.1.2.4]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
deoD; purine-nucleoside phosphorylase [EC:2.4.2.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dgkA; undecaprenol kinase [EC:2.7.1.66]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
DHFR, folA; dihydrofolate reductase [EC:1.5.1.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dinB; DNA polymerase IV [EC:2.7.7.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dinG; ATP-dependent DNA helicase DinG [EC:3.6.4.12]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dinJ; DNA-damage-inducible protein J	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
divIC, divA; cell division protein DivIC	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
divIVA; cell division initiation protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
DLAT, aceF, pdhC; pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dltA; D-alanine–poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dltB; membrane protein involved in D-alanine export	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dltC; D-alanine–poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dltD; D-alanine transfer protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dnaA; chromosomal replication initiator protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dnaB; replication initiation and membrane attachment protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dnaB; replicative DNA helicase [EC:3.6.4.12]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dnaD; DNA replication protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dnaG; DNA primase [EC:2.7.7.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dnaI; primosomal protein DnaI	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dnaJ; molecular chaperone DnaJ	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dnaK, HSPA9; molecular chaperone DnaK	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dps; starvation-inducible DNA-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dtd, DTD1; D-tyrosyl-tRNA(Tyr) deacylase [EC:3.1.-.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E1.1.1.3; homoserine dehydrogenase [EC:1.1.1.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E1.1.3.21; alpha-glycerophosphate oxidase [EC:1.1.3.21]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E1.2.3.3, poxL; pyruvate oxidase [EC:1.2.3.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E1.7.1.7, guaC; GMP reductase [EC:1.7.1.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E2.2.1.6S, ilvH, ilvN; acetolactate synthase I/III small subunit [EC:2.2.1.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E2.3.1.8, pta; phosphate acetyltransferase [EC:2.3.1.8]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E2.3.3.10; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E2.7.1.36, MVK, mvaK1; mevalonate kinase [EC:2.7.1.36]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E2.7.1.71, aroK, aroL; shikimate kinase [EC:2.7.1.71]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E2.7.4.2, mvaK2; phosphomevalonate kinase [EC:2.7.4.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E2.7.4.8, gmk; guanylate kinase [EC:2.7.4.8]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E2.7.6.5X; putative GTP pyrophosphokinase [EC:2.7.6.5]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E2.7.7.3A, coaD, kdtB; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E3.1.3.16; protein phosphatase [EC:3.1.3.16]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E3.1.3.25, IMPA, suhB; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E3.1.3.41; 4-nitrophenyl phosphatase [EC:3.1.3.41]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E3.2.1.85, lacG; 6-phospho-beta-galactosidase [EC:3.2.1.85]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E3.4.13.-; D-alanyl-D-alanine dipeptidase [EC:3.4.13.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E3.6.3.8; Ca2+-transporting ATPase [EC:3.6.3.8]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E4.1.3.3, nanA, NPL; N-acetylneuraminate lyase [EC:4.1.3.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
efp; elongation factor P	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
engA, der; GTPase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
engB; GTP-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ENO, eno; enolase [EC:4.2.1.11]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
era, ERAL1; GTPase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
estA; putative tributyrin esterase [EC:3.1.1.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
eta; exfoliative toxin A/B	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ezrA; septation ring formation regulator	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
fabM; trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:5.3.3.14]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
fer; ferredoxin	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
flA; adenosyl-fluoride synthase [EC:2.5.1.63]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
folP; dihydropteroate synthase [EC:2.5.1.15]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
frr, MRRF, RRF; ribosome recycling factor	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
fruK; 1-phosphofructokinase [EC:2.7.1.56]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
fruR2, fruR; DeoR family transcriptional regulator, fructose operon transcriptional repressor	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ftsA; cell division protein FtsA	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ftsE; cell division transport system ATP-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ftsH, hflB; cell division protease FtsH [EC:3.4.24.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ftsQ; cell division protein FtsQ	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ftsW, spoVE; cell division protein FtsW	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ftsX; cell division transport system permease protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ftsY; fused signal recognition particle receptor	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ftsZ; cell division protein FtsZ	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
fusA, GFM, EFG; elongation factor G	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
galK; galactokinase [EC:2.7.1.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
galM, GALM; aldose 1-epimerase [EC:5.1.3.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
galT, GALT; UDPglucose–hexose-1-phosphate uridylyltransferase [EC:2.7.7.12]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
gatA, QRSL1; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
gatB, PET112; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
gatC, GATC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
GBE1, glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
gidA, mnmG, MTO1; tRNA uridine 5-carboxymethylaminomethyl modification enzyme	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
glgA; starch synthase [EC:2.4.1.21]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
glk; glucokinase [EC:2.7.1.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
glmM; phosphoglucosamine mutase [EC:5.4.2.10]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
glmS, GFPT; glucosamine—fructose-6-phosphate aminotransferase (isomerizing) [EC:2.6.1.16]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
glnR; MerR family transcriptional regulator, glutamine synthetase repressor	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
GLO1, gloA; lactoylglutathione lyase [EC:4.4.1.5]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
glpK, GK; glycerol kinase [EC:2.7.1.30]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
glxK, garK; glycerate 2-kinase [EC:2.7.1.165]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
gph; phosphoglycolate phosphatase [EC:3.1.3.18]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
gpx; glutathione peroxidase [EC:1.11.1.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
greA; transcription elongation factor GreA	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
groEL, HSPD1; chaperonin GroEL	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
groES, HSPE1; chaperonin GroES	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
GRPE; molecular chaperone GrpE	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
GSP13; general stress protein 13	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
GSR, gor; glutathione reductase (NADPH) [EC:1.8.1.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
gyrA; DNA gyrase subunit A [EC:5.99.1.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
gyrB; DNA gyrase subunit B [EC:5.99.1.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
hemH, FECH; protoporphyrin/coproporphyrin ferrochelatase [EC:4.99.1.1 4.99.1.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
hemK, prmC, HEMK; release factor glutamine methyltransferase [EC:2.1.1.297]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
hflX; GTPase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
HINT1, hinT, hit; histidine triad (HIT) family protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
hlyIII; hemolysin III	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
holA; DNA polymerase III subunit delta [EC:2.7.7.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
holB; DNA polymerase III subunit delta’ [EC:2.7.7.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
hprK, ptsK; HPr kinase/phosphorylase [EC:2.7.11.- 2.7.4.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
hrcA; heat-inducible transcriptional repressor	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
hslO; molecular chaperone Hsp33	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
htpX; heat shock protein HtpX [EC:3.4.24.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
htsT; energy-coupling factor transport system substrate-specific component	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
hupB; DNA-binding protein HU-beta	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
idi, IDI; isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ilvC; ketol-acid reductoisomerase [EC:1.1.1.86]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
infA; translation initiation factor IF-1	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
infB, MTIF2; translation initiation factor IF-2	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
infC, MTIF3; translation initiation factor IF-3	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
iscU, nifU; nitrogen fixation protein NifU and related proteins	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
jag; spoIIIJ-associated protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K00243; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K03710; GntR family transcriptional regulator	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K06878; tRNA-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K06885; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K06890; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K06929; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K06940; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K06960; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K07009; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K07015; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K07030; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K07040; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K07058; membrane protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K07082; UPF0755 protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K07089; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K07095; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K07105; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K07124; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K07139; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K07146; UPF0176 protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K07166; ACT domain-containing protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K07177; Lon-like protease	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K07461; putative endonuclease	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K08303; putative protease [EC:3.4.-.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K08884; serine/threonine protein kinase, bacterial [EC:2.7.11.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K08974; putative membrane protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K08987; putative membrane protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K08998; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K09155; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K09157; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K09747; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K09762; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K09787; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K09790; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K09861; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K09962; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K09976; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K11145; ribonuclease III family protein [EC:3.1.26.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
K17076, lysY; putative lysine transport system ATP-binding protein [EC:3.6.3.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
kch, trkA, mthK, pch; voltage-gated potassium channel	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
lacT; transcriptional antiterminator	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
lemA; LemA protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
lepA; GTP-binding protein LepA	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
leuB, IMDH; 3-isopropylmalate dehydrogenase [EC:1.1.1.85]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
leuC, IPMI-L; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
leuD, IPMI-S; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
lgt, umpA; phosphatidylglycerol:prolipoprotein diacylglycerol transferase [EC:2.-.-.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
liaR; two-component system, NarL family, response regulator LiaR	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
livF; branched-chain amino acid transport system ATP-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
livG; branched-chain amino acid transport system ATP-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
livH; branched-chain amino acid transport system permease protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
livK; branched-chain amino acid transport system substrate-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
livM; branched-chain amino acid transport system permease protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
lplA, lplJ; lipoate—protein ligase [EC:6.3.1.20]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
lspA; signal peptidase II [EC:3.4.23.36]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
lysA; diaminopimelate decarboxylase [EC:4.1.1.20]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
lysC; aspartate kinase [EC:2.7.2.4]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
lysX2; putative lysine transport system permease protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
maa; maltose O-acetyltransferase [EC:2.3.1.79]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
malQ; 4-alpha-glucanotransferase [EC:2.4.1.25]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
manA, MPI; mannose-6-phosphate isomerase [EC:5.3.1.8]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
map; methionyl aminopeptidase [EC:3.4.11.18]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mapP; maltose 6’-phosphate phosphatase [EC:3.1.3.90]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
MCH; medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mecA1_2; adapter protein MecA 1/2	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
metA; homoserine O-succinyltransferase/O-acetyltransferase [EC:2.3.1.46 2.3.1.31]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
metB; cystathionine gamma-synthase [EC:2.5.1.48]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
metE; 5-methyltetrahydropteroyltriglutamate–homocysteine methyltransferase [EC:2.1.1.14]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
metF, MTHFR; methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
metK; S-adenosylmethionine synthetase [EC:2.5.1.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
metN; D-methionine transport system ATP-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
metQ; D-methionine transport system substrate-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
metY; O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mfd; transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
MFS.CP; MFS transporter, CP family, cyanate transporter	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mgs, bgsB; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mgtA, mgtB; Mg2+-importing ATPase [EC:3.6.3.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mnmA, trmU; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mraW, rsmH; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mrcA; penicillin-binding protein 1A [EC:2.4.1.129 3.4.16.4]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mreC; rod shape-determining protein MreC	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mreD; rod shape-determining protein MreD	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mscL; large conductance mechanosensitive channel	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mscS; small conductance mechanosensitive channel	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mtaD; 5-methylthioadenosine/S-adenosylhomocysteine deaminase [EC:3.5.4.31 3.5.4.28]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mtnN, mtn, pfs; adenosylhomocysteine nucleosidase [EC:3.2.2.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mtsA; iron/zinc/manganese/copper transport system substrate-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mtsB; iron/zinc/manganese/copper transport system ATP-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mtsC; iron/zinc/manganese/copper transport system permease protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mtsT; energy-coupling factor transport system substrate-specific component	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
murC; UDP-N-acetylmuramate–alanine ligase [EC:6.3.2.8]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
murD; UDP-N-acetylmuramoylalanine–D-glutamate ligase [EC:6.3.2.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase [EC:6.3.2.13]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
murF; UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase [EC:6.3.2.10]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
murG; UDP-N-acetylglucosamine–N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
murI; glutamate racemase [EC:5.1.1.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
murM; serine/alanine adding enzyme [EC:2.3.2.10]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
murN; alanine adding enzyme [EC:2.3.2.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mutL; DNA mismatch repair protein MutL	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mutM, fpg; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mutS; DNA mismatch repair protein MutS	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mutS2; DNA mismatch repair protein MutS2	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
mvaA; hydroxymethylglutaryl-CoA reductase [EC:1.1.1.88]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
MVD, mvaD; diphosphomevalonate decarboxylase [EC:4.1.1.33]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
nadE; NAD+ synthase [EC:6.3.1.5]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
nagA, AMDHD2; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
nanE; N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
niaX; niacin transporter	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
npdA; NAD-dependent deacetylase [EC:3.5.1.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
nrdH; glutaredoxin-like protein NrdH	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
nrdR; transcriptional repressor NrdR	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
NTH; endonuclease III [EC:4.2.99.18]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
nusA; N utilization substance protein A	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
nusB; N utilization substance protein B	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
nusG; transcriptional antiterminator NusG	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
obgE, cgtA; GTPase [EC:3.6.5.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ogt, MGMT; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
oppB; oligopeptide transport system permease protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
oppC; oligopeptide transport system permease protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
oppD; oligopeptide transport system ATP-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
oppF; oligopeptide transport system ATP-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
opuA; osmoprotectant transport system ATP-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
opuBD; osmoprotectant transport system permease protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
paaI; acyl-CoA thioesterase [EC:3.1.2.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pabBC; para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:2.6.1.85 4.1.3.38]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
parB, spo0J; chromosome partitioning protein, ParB family	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
parC; topoisomerase IV subunit A [EC:5.99.1.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
parE; topoisomerase IV subunit B [EC:5.99.1.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
patA, rscA, lmrC, satA; ATP-binding cassette, subfamily B, multidrug efflux pump	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
patA; aminotransferase [EC:2.6.1.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
patB, malY; cystathione beta-lyase [EC:4.4.1.8]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
patB, rscB, lmrC, satB; ATP-binding cassette, subfamily B, multidrug efflux pump	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pbp1b; penicillin-binding protein 1B	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pbp2A; penicillin-binding protein 2A [EC:2.4.1.129 3.4.16.4]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pbp2B, penA; penicillin-binding protein 2B	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pbp2X; penicillin-binding protein 2X	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pbuG; putative MFS transporter, AGZA family, xanthine/uracil permease	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PDHB, pdhB; pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pdp; pyrimidine-nucleoside phosphorylase [EC:2.4.2.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pepA; glutamyl aminopeptidase [EC:3.4.11.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pepF, pepB; oligoendopeptidase F [EC:3.4.24.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pepN; aminopeptidase N [EC:3.4.11.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pepO; putative endopeptidase [EC:3.4.24.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pepQ; Xaa-Pro dipeptidase [EC:3.4.13.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pepT; tripeptide aminopeptidase [EC:3.4.11.4]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PGD, gnd, gntZ; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pgl; 6-phosphogluconolactonase [EC:3.1.1.31]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pgm; phosphoglucomutase [EC:5.4.2.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pgsA, PGS1; CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pheA2; prephenate dehydratase [EC:4.2.1.51]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
phnA; protein PhnA	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
phoH, phoL; phosphate starvation-inducible protein PhoH and related proteins	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
phoU; phosphate transport system protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PK, pyk; pyruvate kinase [EC:2.7.1.40]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
plsX; glycerol-3-phosphate acyltransferase PlsX [EC:2.3.1.15]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
plsY; glycerol-3-phosphate acyltransferase PlsY [EC:2.3.1.15]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pncB, NAPRT1; nicotinate phosphoribosyltransferase [EC:6.3.4.21]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
polA; DNA polymerase I [EC:2.7.7.7]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
potA; spermidine/putrescine transport system ATP-binding protein [EC:3.6.3.31]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
potB; spermidine/putrescine transport system permease protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
potC; spermidine/putrescine transport system permease protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
potD; spermidine/putrescine transport system substrate-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ppaC; manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PPCDC, coaC; phosphopantothenoylcysteine decarboxylase [EC:4.1.1.36]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PPCS, COAB; phosphopantothenate—cysteine ligase (ATP) [EC:6.3.2.51]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pphA; serine/threonine protein phosphatase 1 [EC:3.1.3.16]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PPIB, ppiB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ppnK, NADK; NAD+ kinase [EC:2.7.1.23]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
praC, xylH; 4-oxalocrotonate tautomerase [EC:5.3.2.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
prfA, MTRF1, MRF1; peptide chain release factor 1	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
prfB; peptide chain release factor 2	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
prfC; peptide chain release factor 3	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
priA; primosomal protein N’ (replication factor Y) (superfamily II helicase) [EC:3.6.4.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
proB; glutamate 5-kinase [EC:2.7.2.11]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
prsA; foldase protein PrsA [EC:5.2.1.8]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pstA; phosphate transport system permease protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pstC; phosphate transport system permease protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pstS; phosphate transport system substrate-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PTH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PTS-Aga-EIIA, agaF; PTS system, N-acetylgalactosamine-specific IIA component [EC:2.7.1.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PTS-EI.PTSI, ptsI; phosphotransferase system, enzyme I, PtsI [EC:2.7.3.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PTS-Fru-EIIC, fruA; PTS system, fructose-specific IIC component	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PTS-Fru1-EIID, levG; PTS system, fructose-specific IID component	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PTS-Glc-EIIC, ptsG; PTS system, glucose-specific IIC component	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PTS-HPR; phosphocarrier protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PTS-Lac-EIIA, lacF; PTS system, lactose-specific IIA component [EC:2.7.1.207]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PTS-Lac-EIIC, lacE; PTS system, lactose-specific IIC component	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PTS-Man-EIIA, manX; PTS system, mannose-specific IIA component [EC:2.7.1.191]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
PTS-Scr-EIIC, scrA, sacP, sacX, ptsS; PTS system, sucrose-specific IIC component	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
punA, PNP; purine-nucleoside phosphorylase [EC:2.4.2.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
purB, ADSL; adenylosuccinate lyase [EC:4.3.2.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
purD; phosphoribosylamine—glycine ligase [EC:6.3.4.13]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
purK; 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
purL, PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
purR; purine operon repressor	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pyrB, PYR2; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pyrD; dihydroorotate dehydrogenase (fumarate) [EC:1.3.98.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pyrDII; dihydroorotate dehydrogenase electron transfer subunit	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pyrF; orotidine-5’-phosphate decarboxylase [EC:4.1.1.23]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pyrG, CTPS; CTP synthase [EC:6.3.4.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pyrH; uridylate kinase [EC:2.7.4.22]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
pyrP, uraA; uracil permease	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
radA, sms; DNA repair protein RadA/Sms	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
radC; DNA repair protein RadC	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rapZ; RNase adapter protein RapZ	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rbfA; ribosome-binding factor A	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rbgA; ribosome biogenesis GTPase A	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rbsB; ribose transport system substrate-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
recA; recombination protein RecA	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
recF; DNA replication and repair protein RecF	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
recG; ATP-dependent DNA helicase RecG [EC:3.6.4.12]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
recN; DNA repair protein RecN (Recombination protein N)	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
recO; DNA repair protein RecO (recombination protein O)	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
recR; recombination protein RecR	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
recU; recombination protein U	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
recX; regulatory protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
relA; GTP pyrophosphokinase [EC:2.7.6.5]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rex; redox-sensing transcriptional repressor	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ridA, tdcF, RIDA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rimM; 16S rRNA processing protein RimM	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rimP; ribosome maturation factor RimP	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rlmA1; 23S rRNA (guanine745-N1)-methyltransferase [EC:2.1.1.187]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rlmB; 23S rRNA (guanosine2251-2’-O)-methyltransferase [EC:2.1.1.185]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rmuC; DNA recombination protein RmuC	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rnhC; ribonuclease HIII [EC:3.1.26.4]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rnmV; ribonuclease M5 [EC:3.1.26.8]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rnpA; ribonuclease P protein component [EC:3.1.26.5]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rnr, vacB; ribonuclease R [EC:3.1.-.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rny; ribonucrease Y [EC:3.1.-.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rnz; ribonuclease Z [EC:3.1.26.11]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rodA, mrdB; rod shape determining protein RodA	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L1, MRPL1, rplA; large subunit ribosomal protein L1	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L10, MRPL10, rplJ; large subunit ribosomal protein L10	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L11, MRPL11, rplK; large subunit ribosomal protein L11	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L13, MRPL13, rplM; large subunit ribosomal protein L13	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L14, MRPL14, rplN; large subunit ribosomal protein L14	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L15, MRPL15, rplO; large subunit ribosomal protein L15	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L16, MRPL16, rplP; large subunit ribosomal protein L16	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L17, MRPL17, rplQ; large subunit ribosomal protein L17	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L18, MRPL18, rplR; large subunit ribosomal protein L18	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L19, MRPL19, rplS; large subunit ribosomal protein L19	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L2, MRPL2, rplB; large subunit ribosomal protein L2	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L20, MRPL20, rplT; large subunit ribosomal protein L20	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L21, MRPL21, rplU; large subunit ribosomal protein L21	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L22, MRPL22, rplV; large subunit ribosomal protein L22	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L23, MRPL23, rplW; large subunit ribosomal protein L23	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L24, MRPL24, rplX; large subunit ribosomal protein L24	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L27, MRPL27, rpmA; large subunit ribosomal protein L27	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L28, MRPL28, rpmB; large subunit ribosomal protein L28	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L29, rpmC; large subunit ribosomal protein L29	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L30, MRPL30, rpmD; large subunit ribosomal protein L30	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L31, rpmE; large subunit ribosomal protein L31	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L32, MRPL32, rpmF; large subunit ribosomal protein L32	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L34, MRPL34, rpmH; large subunit ribosomal protein L34	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L35, MRPL35, rpmI; large subunit ribosomal protein L35	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L4, MRPL4, rplD; large subunit ribosomal protein L4	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L5, MRPL5, rplE; large subunit ribosomal protein L5	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L6, MRPL6, rplF; large subunit ribosomal protein L6	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L7, MRPL12, rplL; large subunit ribosomal protein L7/L12	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-L9, MRPL9, rplI; large subunit ribosomal protein L9	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S1, rpsA; small subunit ribosomal protein S1	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S10, MRPS10, rpsJ; small subunit ribosomal protein S10	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S11, MRPS11, rpsK; small subunit ribosomal protein S11	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S13, rpsM; small subunit ribosomal protein S13	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S14, MRPS14, rpsN; small subunit ribosomal protein S14	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S15, MRPS15, rpsO; small subunit ribosomal protein S15	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S16, MRPS16, rpsP; small subunit ribosomal protein S16	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S17, MRPS17, rpsQ; small subunit ribosomal protein S17	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S19, rpsS; small subunit ribosomal protein S19	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S20, rpsT; small subunit ribosomal protein S20	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S21, MRPS21, rpsU; small subunit ribosomal protein S21	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S3, rpsC; small subunit ribosomal protein S3	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S4, rpsD; small subunit ribosomal protein S4	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S5, MRPS5, rpsE; small subunit ribosomal protein S5	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S7, MRPS7, rpsG; small subunit ribosomal protein S7	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S8, rpsH; small subunit ribosomal protein S8	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
RP-S9, MRPS9, rpsI; small subunit ribosomal protein S9	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rpe, RPE; ribulose-phosphate 3-epimerase [EC:5.1.3.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rpoC; DNA-directed RNA polymerase subunit beta’ [EC:2.7.7.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rpoD; RNA polymerase primary sigma factor	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rpoE; DNA-directed RNA polymerase subunit delta	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rseP; regulator of sigma E protease [EC:3.4.24.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rsmB, sun; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rsmC; 16S rRNA (guanine1207-N2)-methyltransferase [EC:2.1.1.172]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rsmD; 16S rRNA (guanine966-N2)-methyltransferase [EC:2.1.1.171]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rsmI; 16S rRNA (cytidine1402-2’-O)-methyltransferase [EC:2.1.1.198]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ruvA; holliday junction DNA helicase RuvA [EC:3.6.4.12]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ruvB; holliday junction DNA helicase RuvB [EC:3.6.4.12]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ruvX; putative holliday junction resolvase [EC:3.1.-.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
saeR; two-component system, OmpR family, response regulator SaeR	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
saeS; two-component system, OmpR family, sensor histidine kinase SaeS [EC:2.7.13.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
scpA; segregation and condensation protein A	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
scpB; segregation and condensation protein B	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
scrR; LacI family transcriptional regulator, sucrose operon repressor	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
secG; preprotein translocase subunit SecG	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
sepF; cell division inhibitor SepF	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
serB, PSPH; phosphoserine phosphatase [EC:3.1.3.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
smc; chromosome segregation protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
smf; DNA processing protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
smpB; SsrA-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
spoU; RNA methyltransferase, TrmH family	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
sstT; serine/threonine transporter	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
sufC; Fe-S cluster assembly ATP-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
sufD; Fe-S cluster assembly protein SufD	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
sulD; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:4.1.2.25 2.7.6.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tatD; TatD DNase family protein [EC:3.1.21.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
TC.APA; basic amino acid/polyamine antiporter, APA family	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
TC.LIVCS; branched-chain amino acid:cation transporter, LIVCS family	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
TC.MATE, SLC47A, norM, mdtK, dinF; multidrug resistance protein, MATE family	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tdk, TK; thymidine kinase [EC:2.7.1.21]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tehB; tellurite methyltransferase [EC:2.1.1.265]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tex; protein Tex	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tgt, QTRT1; queuine tRNA-ribosyltransferase [EC:2.4.2.29]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
thrB1; homoserine kinase [EC:2.7.1.39]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
thrC; threonine synthase [EC:4.2.3.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
thyA, TYMS; thymidylate synthase [EC:2.1.1.45]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tig; trigger factor	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tlyA; 23S rRNA (cytidine1920-2’-O)/16S rRNA (cytidine1409-2’-O)-methyltransferase [EC:2.1.1.226 2.1.1.227]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tlyC; putative hemolysin	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tmk, DTYMK; dTMP kinase [EC:2.7.4.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
topA; DNA topoisomerase I [EC:5.99.1.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
TPI, tpiA; triosephosphate isomerase (TIM) [EC:5.3.1.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tpx; thiol peroxidase, atypical 2-Cys peroxiredoxin [EC:1.11.1.15]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
trmB, METTL1; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
trmFO, gid; methylenetetrahydrofolate–tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
trmK; tRNA (adenine22-N1)-methyltransferase [EC:2.1.1.217]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
trmL, cspR; tRNA (cytidine/uridine-2’-O-)-methyltransferase [EC:2.1.1.207]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
trpA; tryptophan synthase alpha chain [EC:4.2.1.20]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
trpC; indole-3-glycerol phosphate synthase [EC:4.1.1.48]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
trpD; anthranilate phosphoribosyltransferase [EC:2.4.2.18]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
trpE; anthranilate synthase component I [EC:4.1.3.27]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
trpG; anthranilate synthase component II [EC:4.1.3.27]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
truA, PUS1; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
truB, PUS4, TRUB1; tRNA pseudouridine55 synthase [EC:5.4.99.25]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tsaC, rimN, SUA5; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tsf, TSFM; elongation factor Ts	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tuf, TUFM; elongation factor Tu	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
typA, bipA; GTP-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
tyrA2; prephenate dehydrogenase [EC:1.3.1.12]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
UGP2, galU, galF; UTP–glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
umuC; DNA polymerase V	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
URA4, pyrC; dihydroorotase [EC:3.5.2.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
uup; ABC transport system ATP-binding/permease protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
uvrA; excinuclease ABC subunit A	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
uvrB; excinuclease ABC subunit B	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
uvrC; excinuclease ABC subunit C	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
vicR; two-component system, OmpR family, response regulator VicR	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
yafQ; mRNA interferase YafQ [EC:3.1.-.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
yajC; preprotein translocase subunit YajC	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ybaK, ebsC; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ybeB; ribosome-associated protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ybeY, yqfG; probable rRNA maturation factor	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ycaJ; putative ATPase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ycgQ; putative membrane protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ychF; ribosome-binding ATPase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ygaC; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
yggS, PROSC; PLP dependent protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
yggT; YggT family protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
yhbH; putative sigma-54 modulation protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
yhbY; RNA-binding protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
yhgE; putative membrane protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
yjbB; phosphate:Na+ symporter	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ylxR; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
yqeH; 30S ribosome assembly GTPase	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
ysxB; uncharacterized protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
znuB; zinc transport system permease protein	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
znuC; zinc transport system ATP-binding protein [EC:3.6.3.-]	2.72204	0.25295	2.52237	7.61729	0.34233	65	2.86160	11.90523	0.35779	93	0.49518	-0.68506	153.10	0.49434	0.55070
bdhAB; butanol dehydrogenase [EC:1.1.1.-]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
bglG1; transcriptional antiterminator	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
cas1; CRISP-associated protein Cas1	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
cas2; CRISPR-associated protein Cas2	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
cpdB; 2’,3’-cyclic-nucleotide 2’-phosphodiesterase / 3’-nucleotidase [EC:3.1.4.16 3.1.3.6]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
csn1, cas9; CRISPR-associated endonuclease Csn1 [EC:3.1.-.-]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
E2.4.1.7; sucrose phosphorylase [EC:2.4.1.7]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
E3.2.1.22B, galA, rafA; alpha-galactosidase [EC:3.2.1.22]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
E4.1.1.49, pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
fbp3; fructose-1,6-bisphosphatase III [EC:3.1.3.11]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
gldA; glycerol dehydrogenase [EC:1.1.1.6]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
higB-1; toxin HigB-1	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
K06871; uncharacterized protein	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
K06962; uncharacterized protein	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
mmuM, BHMT2; homocysteine S-methyltransferase [EC:2.1.1.10]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
msmE; raffinose/stachyose/melibiose transport system substrate-binding protein	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
msmF; raffinose/stachyose/melibiose transport system permease protein	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
msmG; raffinose/stachyose/melibiose transport system permease protein	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
ppsR; [pyruvate, water dikinase]-phosphate phosphotransferase / [pyruvate, water dikinase] kinase [EC:2.7.4.28 2.7.11.33]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
PTS-Cel-EIIA, celC, chbA; PTS system, cellobiose-specific IIA component [EC:2.7.1.196 2.7.1.205]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
PTS-Cel-EIIB, celA, chbB; PTS system, cellobiose-specific IIB component [EC:2.7.1.196 2.7.1.205]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
PTS-Ula-EIIA, ulaC, sgaA; PTS system, ascorbate-specific IIA component [EC:2.7.1.194]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
queG; epoxyqueuosine reductase [EC:1.17.99.6]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
rpoE; RNA polymerase sigma-70 factor, ECF subfamily	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
serA, PHGDH; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
serC, PSAT1; phosphoserine aminotransferase [EC:2.6.1.52]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
ulaG; L-ascorbate 6-phosphate lactonase [EC:3.1.1.-]	1.77722	0.18717	1.64000	4.82494	0.27245	65	1.87312	6.06699	0.25541	93	0.37345	-0.62423	146.96	0.53345	0.55070
E3.4.21.96; lactocepin [EC:3.4.21.96]	1.62083	0.17031	1.49510	3.98064	0.24747	65	1.70870	5.03262	0.23262	93	0.33964	-0.62889	147.15	0.53040	0.55070
E2.6.1.11, argD; acetylornithine aminotransferase [EC:2.6.1.11]	1.61910	0.17025	1.49371	3.98269	0.24753	65	1.70674	5.02571	0.23246	93	0.33958	-0.62737	147.08	0.53139	0.55070
HEXA_B; hexosaminidase [EC:3.2.1.52]	1.61910	0.17025	1.49371	3.98269	0.24753	65	1.70674	5.02571	0.23246	93	0.33958	-0.62737	147.08	0.53139	0.55070
rgpA; rhamnosyltransferase [EC:2.4.1.-]	1.61910	0.17025	1.49371	3.98269	0.24753	65	1.70674	5.02571	0.23246	93	0.33958	-0.62737	147.08	0.53139	0.55070
ACO, acnA; aconitate hydratase [EC:4.2.1.3]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
acrR, smeT; TetR/AcrR family transcriptional regulator, acrAB operon repressor	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
ald; alanine dehydrogenase [EC:1.4.1.1]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
aphA; kanamycin kinase [EC:2.7.1.95]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
arcA; arginine deiminase [EC:3.5.3.6]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
arcC; carbamate kinase [EC:2.7.2.2]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
argB; acetylglutamate kinase [EC:2.7.2.8]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
argG, ASS1; argininosuccinate synthase [EC:6.3.4.5]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
argH, ASL; argininosuccinate lyase [EC:4.3.2.1]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
argJ; glutamate N-acetyltransferase / amino-acid N-acetyltransferase [EC:2.3.1.35 2.3.1.1]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
ATPVA, ntpA, atpA; V/A-type H+/Na+-transporting ATPase subunit A [EC:3.6.3.14 3.6.3.15]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
ATPVB, ntpB, atpB; V/A-type H+/Na+-transporting ATPase subunit B	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
ATPVC, ntpC, atpC; V/A-type H+/Na+-transporting ATPase subunit C	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
ATPVD, ntpD, atpD; V/A-type H+/Na+-transporting ATPase subunit D	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
ATPVE, ntpE, atpE; V/A-type H+/Na+-transporting ATPase subunit E	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
ATPVF, ntpF, atpF; V/A-type H+/Na+-transporting ATPase subunit F	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
ATPVI, ntpI, atpI; V/A-type H+/Na+-transporting ATPase subunit I	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
ATPVK, ntpK, atpK; V/A-type H+/Na+-transporting ATPase subunit K	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
BDH, butB; (R,R)-butanediol dehydrogenase / meso-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.4 1.1.1.- 1.1.1.303]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
CHO1, pssA; CDP-diacylglycerol—serine O-phosphatidyltransferase [EC:2.7.8.8]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
CS, gltA; citrate synthase [EC:2.3.3.1]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
dagK; diacylglycerol kinase (ATP) [EC:2.7.1.107]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
dgs, bgsA; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-glucosyltransferase [EC:2.4.1.208]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
E1.1.1.1, adh; alcohol dehydrogenase [EC:1.1.1.1]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
E2.4.-.-; glycosyltransferase [EC:2.4.-.-]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
E2.4.1.5; dextransucrase [EC:2.4.1.5]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
E2.7.1.4, scrK; fructokinase [EC:2.7.1.4]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
E2.7.7.24, rfbA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
E3.1.3.15B; histidinol-phosphatase (PHP family) [EC:3.1.3.15]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
E3.1.3.5; 5’-nucleotidase [EC:3.1.3.5]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
E3.4.16.4; D-alanyl-D-alanine carboxypeptidase [EC:3.4.16.4]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
E4.2.1.46, rfbB, rffG; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
E4.3.1.4; formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
efeB; deferrochelatase/peroxidase EfeB [EC:1.11.1.-]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
efeO; iron uptake system component EfeO	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
efrA; ATP-binding cassette, subfamily B, multidrug efflux pump	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
efrB; ATP-binding cassette, subfamily B, multidrug efflux pump	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
elaA; ElaA protein	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
fctD; glutamate formiminotransferase [EC:2.1.2.5]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
FLOT; flotillin	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
fruA; fructan beta-fructosidase [EC:3.2.1.80]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
FTR, FTH1, efeU; high-affinity iron transporter	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
gltP, gltT; proton glutamate symport protein	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
gshA; glutamate–cysteine ligase [EC:6.3.2.2]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
hisB; imidazoleglycerol-phosphate dehydratase [EC:4.2.1.19]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
hisD; histidinol dehydrogenase [EC:1.1.1.23]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
hisE; phosphoribosyl-ATP pyrophosphohydrolase [EC:3.6.1.31]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
hisF; cyclase [EC:4.1.3.-]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
hisG; ATP phosphoribosyltransferase [EC:2.4.2.17]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
hisH; glutamine amidotransferase [EC:2.4.2.-]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
hisI; phosphoribosyl-AMP cyclohydrolase [EC:3.5.4.19]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
hisZ; ATP phosphoribosyltransferase regulatory subunit	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
hutG; formiminoglutamase [EC:3.5.3.8]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
hutH, HAL; histidine ammonia-lyase [EC:4.3.1.3]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
hutU, UROC1; urocanate hydratase [EC:4.2.1.49]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
irr; two-component system, OmpR family, response regulator Irr	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
K01436; amidohydrolase [EC:3.5.1.-]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
K06889; uncharacterized protein	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
K06950; uncharacterized protein	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
K07004; uncharacterized protein	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
K07023; putative hydrolases of HD superfamily	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
K07727; putative transcriptional regulator	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
K09153; uncharacterized protein	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
K13653; AraC family transcriptional regulator	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
lacY; MFS transporter, OHS family, lactose permease	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
lacZ; beta-galactosidase [EC:3.2.1.23]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
licR; lichenan operon transcriptional antiterminator	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
licT, bglG; beta-glucoside operon transcriptional antiterminator	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
ltaS; lipoteichoic acid synthase [EC:2.7.8.20]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
nudB, ntpA; dihydroneopterin triphosphate diphosphatase [EC:3.6.1.67]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
OTC, argF, argI; ornithine carbamoyltransferase [EC:2.1.3.3]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
pat; phosphinothricin acetyltransferase [EC:2.3.1.183]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
pepDA, pepDB; dipeptidase [EC:3.4.-.-]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
pepE; dipeptidase E [EC:3.4.13.21]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
perR; Fur family transcriptional regulator, peroxide stress response regulator	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
phnB; PhnB protein	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
prdX, proX; Ala-tRNA(Pro) deacylase [EC:3.1.1.-]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
PTS-Tre-EIIC, treB; PTS system, trehalose-specific IIC component	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
rfbC, rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
rfbD, rmlD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
rgpB; rhamnosyltransferase [EC:2.4.1.-]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
rgpF; rhamnosyltransferase [EC:2.4.1.-]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
rluA; tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
RP-L36, MRPL36, rpmJ; large subunit ribosomal protein L36	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
secE; preprotein translocase subunit SecE	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
sprL; SprT-like protein	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
srtB; sortase B [EC:3.4.22.70]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
tagE; poly(glycerol-phosphate) alpha-glucosyltransferase [EC:2.4.1.52]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
tatA; sec-independent protein translocase protein TatA	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
tatC; sec-independent protein translocase protein TatC	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
TC.DAACS; dicarboxylate/amino acid:cation (Na+ or H+) symporter, DAACS family	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
TC.ZIP, zupT, ZRT3, ZIP2; zinc transporter, ZIP family	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
treC; trehalose-6-phosphate hydrolase [EC:3.2.1.93]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
treR2, treR; GntR family transcriptional regulator, trehalose operon transcriptional repressor	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
ubiA; 4-hydroxybenzoate polyprenyltransferase [EC:2.5.1.39]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
wecA, tagO, rfe; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
yaeR; glyoxylase I family protein	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
ybaZ; methylated-DNA-protein-cysteine methyltransferase related protein	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
yghU, yfcG; GSH-dependent disulfide-bond oxidoreductase [EC:1.8.4.-]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
yjgM; putative acetyltransferase [EC:2.3.1.-]	1.61738	0.17020	1.49231	3.98499	0.24760	65	1.70479	5.01952	0.23232	93	0.33953	-0.62581	147.02	0.53241	0.55070
parA, soj; chromosome partitioning protein	0.03797	0.02823	0.03077	0.06154	0.03077	65	0.04301	0.17204	0.04301	93	0.05288	-0.23148	152.75	0.81725	0.81725
PTS-Gut-EIIC, srlA; PTS system, glucitol/sorbitol-specific IIC component	0.03797	0.02823	0.03077	0.06154	0.03077	65	0.04301	0.17204	0.04301	93	0.05288	-0.23148	152.75	0.81725	0.81725
ATPVG, ahaH, atpH; V/A-type H+/Na+-transporting ATPase subunit G/H	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
cotH; spore coat protein H	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
emrE, qac, mmr, smr; small multidrug resistance pump	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
glf; UDP-galactopyranose mutase [EC:5.4.99.9]	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
gloB, HAGH; hydroxyacylglutathione hydrolase [EC:3.1.2.6]	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
K07054; uncharacterized protein	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
K07078; uncharacterized protein	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
K07088; uncharacterized protein	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
K07498; putative transposase	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
K09384; uncharacterized protein	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
K10120, msmE; fructooligosaccharide transport system substrate-binding protein	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
K10121, msmF; fructooligosaccharide transport system permease protein	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
K10122, msmG; fructooligosaccharide transport system permease protein	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
ltaE; threonine aldolase [EC:4.1.2.48]	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
ME2, sfcA, maeA; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
mntH; manganese transport protein	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
panE, apbA; 2-dehydropantoate 2-reductase [EC:1.1.1.169]	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
pcaC; 4-carboxymuconolactone decarboxylase [EC:4.1.1.44]	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
proV; glycine betaine/proline transport system ATP-binding protein [EC:3.6.3.32]	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
proX; glycine betaine/proline transport system substrate-binding protein	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
PTS-Bgl-EIIC, bglF, bglP; PTS system, beta-glucoside-specific IIC component	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
PTS-Gut-EIIA, srlB; PTS system, glucitol/sorbitol-specific IIA component [EC:2.7.1.198]	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
qrtT; energy-coupling factor transport system substrate-specific component	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
racD; aspartate racemase [EC:5.1.1.13]	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
rgpE; glucosyltransferase [EC:2.4.1.-]	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
rstA1; phage replication initiation protein	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
sbcC, rad50; DNA repair protein SbcC/Rad50	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
srlD; sorbitol-6-phosphate 2-dehydrogenase [EC:1.1.1.140]	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
TC.SSS; solute:Na+ symporter, SSS family	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
topB; DNA topoisomerase III [EC:5.99.1.2]	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
tyrA1; chorismate mutase [EC:5.4.99.5]	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
virD4, lvhD4; type IV secretion system protein VirD4	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725
xfp, xpk; xylulose-5-phosphate/fructose-6-phosphate phosphoketolase [EC:4.1.2.9 4.1.2.22]	0.01899	0.01412	0.01538	0.01538	0.01538	65	0.02151	0.04301	0.02151	93	0.02644	-0.23148	152.75	0.81725	0.81725

plot.dat <- tb.ra %>%
  arrange(p) %>%
  slice_head(n=50)%>%
  mutate(
    description = fct_reorder(description, `Overall Mean`),
    description = factor(description, levels = levels(description), ordered=T)
  ) %>%
  arrange(description) %>%
  mutate(
    id = 1:n(),
    step = ifelse(id%%2 == 0, 1, 0),
    Mean_diff = `Tumor Mean` - `Non-Tumor Mean`,
    diff_se = SEpooled,
    Mean_diff_ll = Mean_diff - qt(0.975, df)*diff_se,
    Mean_diff_ul = Mean_diff + qt(0.975, df)*diff_se
  ) %>%
  pivot_longer(
    cols=contains("Mean"),
    names_to = "group",
    values_to = "mean"
  )



p1.d <- plot.dat %>%
  filter(group %in% c("Tumor Mean","Non-Tumor Mean")) %>%
  mutate(
    group = ifelse(group == "Tumor Mean", "Tumor", "Non-Tumor"),
    col = ifelse(step == 1, "grey90", "white"),
    h=1, w=Inf
    
  )
p1 <- ggplot()+
  geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_bar(data=p1.d,
             aes(x=mean, y=description,
                 group=group, color=group,
                 fill=group),
             stat="identity",position = "dodge",
             alpha = 1)+
    labs(x="Mean Abundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      plot.margin = unit(c(1,0,1,1), "lines")
    )

p2.d <- plot.dat %>%
  filter(group %in% c("Mean_diff", "Mean_diff_ll", "Mean_diff_ul")) %>%
  pivot_wider(
    names_from = group,
    values_from = mean
  ) %>%
  mutate(
    group = ifelse(Mean_diff > 0, "Tumor", "Non-Tumor"),
    p = sprintf("%.3f", round(p,3)),
    ll = min(Mean_diff_ll)-0.01,
    ul = max(Mean_diff_ul)+0.01
  )
p2<-ggplot(p2.d, aes(x=Mean_diff, y=description))+
    geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_vline(xintercept = 0, linetype="dashed", alpha=0.5)+
    geom_segment(aes(x=Mean_diff_ll, y=description, xend=Mean_diff_ul, yend=description))+
    geom_point(aes(fill=group, color=group))+
    geom_text(aes(label=p, x=unique(ul)+0.1))+
    coord_cartesian(xlim = c(unique(p2.d$ll), unique(p2.d$ul)),
                    clip = 'off') +
    annotate("text", x=unique(p2.d$ul)+0.2,y = 25,
             angle=90,
             label="p-value (uncorrected)")+
    labs(x="Mean Difference in Abundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      axis.title.y = element_blank(),
      axis.text.y = element_blank(),
      axis.line.y = element_blank(),
      axis.ticks.y = element_blank(),
      plot.margin = unit(c(1,4,1,0), "lines")
    )

# plot
p1 + p2 +
  plot_annotation(title="Stratefied KO Data - Streptococcus sanguinis : First 50 descriptions with lowest p-value (uncorrected)")

Modeling Difference between Tumor and Non-Tumor

For the modeling, we used a generalized linear mixed model (GLMM).

First, we looked at the biserial correlation between the abundance of each description and the tumor status.

tb <- mydata %>%
  group_by(description)%>%
  summarise(
    r = cor(tumor, Abundance)
  ) %>%
  mutate(
    M=mean(r)
  )

ggplot(tb, aes(x=r))+
  geom_density()+
  geom_vline(aes(xintercept = M))+
  labs(x="Biserial Correlation",title="Relationship between description abundance and tumor (tumor vs. non-tumor)")+
  theme(panel.grid = element_blank())

Next, we need the data to be on an interpretable scale. First, let’s use the raw abundance like scale.

p <- ggplot(mydata, aes(x=Abundance))+
  geom_density()
p

mydata <- mydata %>%
  mutate(Abundance.dich=ifelse(Abundance==0, 0, 1))
table(mydata$Abundance.dich)

     0      1 
 26243 150243 

Let’s first run models by description so that we can avoid the nesting issue initially. We will come back to this to conduct the final model (it will be more powerful).

DESCRIPTIONS <- unique(mydata$description)
i<-1
dat0 <- mydata %>% filter(description==DESCRIPTIONS[i])

# quasipossion (approximately negative binom) give an approx. answer.
fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
summary(fit0)

Call:
glm(formula = Abundance ~ 1 + tumor, family = quasipoisson(link = "log"), 
    data = dat0)

Deviance Residuals: 
   Min      1Q  Median      3Q     Max  
-2.392  -2.036  -0.885   1.016   4.266  

Coefficients:
            Estimate Std. Error t value Pr(>|t|)    
(Intercept)    1.051      0.118    8.93  1.1e-15 ***
tumor         -0.126      0.191   -0.66     0.51    
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for quasipoisson family taken to be 3.6927)

    Null deviance: 550.16  on 157  degrees of freedom
Residual deviance: 548.53  on 156  degrees of freedom
AIC: NA

Number of Fisher Scoring iterations: 5

NExt, let’s model the percent relative abundance. This will allow us to make inference about the difference average relative abundance. Which is a simpler interpretation than trying to model differences in the log relative abundance which will need to be interpreted as the multiplicative relative change.

results.out <- as.data.frame(matrix(ncol=4, nrow=length(DESCRIPTIONS)))
colnames(results.out) <- c("description", "Est", "SE", "p")
#results.out$description <-DESCRIPTIONS

i <- 1
for(i in 1:length(DESCRIPTIONS)){
#for(i in 1:5){ 
  dat0 <- mydata %>%
    filter(description == DESCRIPTIONS[i])
  fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
  fit.sum <- summary(fit0)
  results.out[i, 1] <- DESCRIPTIONS[i]
  results.out[i, 2:4] <- fit.sum$coefficients[2, c(1,2,4)]
}

results.out$fdr_p <- p.adjust(results.out$p, method="fdr")

kable(results.out, format="html", digits=3) %>%
  kable_styling(full_width = T)%>%
  scroll_box(width="100%", height="600px")

description	Est	SE	p	fdr_p
aadK; aminoglycoside 6-adenylyltransferase [EC:2.7.7.-]	-0.126	0.191	0.509	0.566
AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]	-0.126	0.191	0.509	0.566
ABC-2.A; ABC-2 type transport system ATP-binding protein	-0.126	0.191	0.509	0.566
ABC-2.CYL.A, cylA; multidrug/hemolysin transport system ATP-binding protein	-0.126	0.191	0.509	0.566
ABC-2.CYL.P, cylB; multidrug/hemolysin transport system permease protein	-0.126	0.191	0.509	0.566
ABC-2.P; ABC-2 type transport system permease protein	-0.126	0.191	0.509	0.566
ABC.CD.A; putative ABC transport system ATP-binding protein	-0.126	0.191	0.510	0.566
ABC.CD.P; putative ABC transport system permease protein	-0.127	0.191	0.509	0.566
ABC.CD.TX; HlyD family secretion protein	-0.128	0.194	0.510	0.566
ABC.FEV.A; iron complex transport system ATP-binding protein [EC:3.6.3.34]	-0.126	0.191	0.509	0.566
ABC.FEV.P; iron complex transport system permease protein	-0.125	0.191	0.513	0.566
ABC.FEV.S; iron complex transport system substrate-binding protein	-0.124	0.191	0.517	0.566
ABC.GLN1.A; putative glutamine transport system ATP-binding protein [EC:3.6.3.-]	-0.126	0.191	0.510	0.566
ABC.GLN1.P; putative glutamine transport system permease protein	-0.126	0.191	0.510	0.566
ABC.GLN1.S; putative glutamine transport system substrate-binding protein	-0.126	0.191	0.510	0.566
ABC.MS.P; multiple sugar transport system permease protein	-0.124	0.191	0.517	0.566
ABC.MS.P1; multiple sugar transport system permease protein	-0.124	0.191	0.517	0.566
ABC.MS.S; multiple sugar transport system substrate-binding protein	-0.123	0.193	0.523	0.566
ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:3.6.3.21]	-0.125	0.191	0.514	0.566
ABC.PA.P; polar amino acid transport system permease protein	-0.125	0.191	0.514	0.566
ABC.PA.S; polar amino acid transport system substrate-binding protein	-0.125	0.191	0.514	0.566
ABC.PE.S; peptide/nickel transport system substrate-binding protein	-0.125	0.191	0.513	0.566
ABC.SS.A; simple sugar transport system ATP-binding protein [EC:3.6.3.17]	-0.126	0.191	0.509	0.566
ABC.SS.P; simple sugar transport system permease protein	-0.126	0.191	0.509	0.566
ABC.X4.A; putative ABC transport system ATP-binding protein	-0.124	0.191	0.517	0.566
ABC.X4.P; putative ABC transport system permease protein	-0.124	0.191	0.517	0.566
ABC.X4.S; putative ABC transport system substrate-binding protein	-0.124	0.191	0.517	0.566
ABCB-BAC; ATP-binding cassette, subfamily B, bacterial	-0.128	0.193	0.509	0.566
ABCC-BAC; ATP-binding cassette, subfamily C, bacterial	-0.125	0.191	0.513	0.566
ABCF3; ATP-binding cassette, subfamily F, member 3	-0.126	0.191	0.509	0.566
accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]	-0.126	0.191	0.510	0.566
accB, bccP; acetyl-CoA carboxylase biotin carboxyl carrier protein	-0.126	0.191	0.509	0.566
accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	-0.126	0.191	0.509	0.566
accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]	-0.126	0.191	0.509	0.566
ackA; acetate kinase [EC:2.7.2.1]	-0.126	0.191	0.509	0.566
acm; lysozyme	-0.126	0.191	0.509	0.566
ACO, acnA; aconitate hydratase [EC:4.2.1.3]	-0.133	0.217	0.540	0.566
acpP; acyl carrier protein	-0.126	0.191	0.509	0.566
acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7]	-0.126	0.191	0.509	0.566
acrR, smeT; TetR/AcrR family transcriptional regulator, acrAB operon repressor	-0.133	0.217	0.540	0.566
acuB; acetoin utilization protein AcuB	-0.126	0.191	0.509	0.566
acyP; acylphosphatase [EC:3.6.1.7]	-0.126	0.191	0.509	0.566
addA; ATP-dependent helicase/nuclease subunit A [EC:3.1.-.- 3.6.4.12]	-0.126	0.191	0.509	0.566
addB; ATP-dependent helicase/nuclease subunit B [EC:3.1.-.- 3.6.4.12]	-0.126	0.191	0.509	0.566
adh2; alcohol dehydrogenase [EC:1.1.1.-]	-0.121	0.201	0.548	0.566
adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1]	-0.126	0.191	0.509	0.566
adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]	-0.126	0.191	0.509	0.566
adk, AK; adenylate kinase [EC:2.7.4.3]	-0.126	0.191	0.509	0.566
afuA, fbpA; iron(III) transport system substrate-binding protein	-0.121	0.201	0.548	0.566
afuB, fbpB; iron(III) transport system permease protein	-0.121	0.201	0.548	0.566
afuC, fbpC; iron(III) transport system ATP-binding protein [EC:3.6.3.30]	-0.121	0.201	0.548	0.566
agaS; tagatose-6-phosphate ketose/aldose isomerase [EC:5.-.-.-]	-0.126	0.191	0.509	0.566
agrA, blpR, fsrA; two-component system, LytTR family, response regulator AgrA	-0.123	0.194	0.528	0.566
agrC, blpH, fsrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]	-0.123	0.193	0.523	0.566
aguA; agmatine deiminase [EC:3.5.3.12]	-0.121	0.201	0.548	0.566
aguB; N-carbamoylputrescine amidase [EC:3.5.1.53]	-0.121	0.201	0.548	0.566
alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]	-0.126	0.191	0.509	0.566
ald; alanine dehydrogenase [EC:1.4.1.1]	-0.133	0.217	0.540	0.566
alr; alanine racemase [EC:5.1.1.1]	-0.126	0.191	0.509	0.566
alsD, budA, aldC; acetolactate decarboxylase [EC:4.1.1.5]	-0.126	0.191	0.509	0.566
ampC; beta-lactamase class C [EC:3.5.2.6]	-0.126	0.191	0.509	0.566
ampS, pepS, ampT; aminopeptidase [EC:3.4.11.-]	-0.126	0.191	0.509	0.566
AMY, amyA, malS; alpha-amylase [EC:3.2.1.1]	-0.126	0.191	0.509	0.566
apbE; FAD:protein FMN transferase [EC:2.7.1.180]	-0.126	0.191	0.509	0.566
aphA; kanamycin kinase [EC:2.7.1.95]	-0.133	0.217	0.540	0.566
APRT, apt; adenine phosphoribosyltransferase [EC:2.4.2.7]	-0.126	0.191	0.509	0.566
aqpZ; aquaporin Z	-0.121	0.201	0.547	0.566
arcA; arginine deiminase [EC:3.5.3.6]	-0.133	0.217	0.540	0.566
arcC; carbamate kinase [EC:2.7.2.2]	-0.133	0.217	0.540	0.566
argB; acetylglutamate kinase [EC:2.7.2.8]	-0.133	0.217	0.540	0.566
argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]	-0.133	0.217	0.540	0.566
argG, ASS1; argininosuccinate synthase [EC:6.3.4.5]	-0.133	0.217	0.540	0.566
argH, ASL; argininosuccinate lyase [EC:4.3.2.1]	-0.133	0.217	0.540	0.566
argJ; glutamate N-acetyltransferase / amino-acid N-acetyltransferase [EC:2.3.1.35 2.3.1.1]	-0.133	0.217	0.540	0.566
argR, ahrC; transcriptional regulator of arginine metabolism	-0.126	0.191	0.509	0.566
aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]	-0.126	0.191	0.509	0.566
AROA1, aroA; chorismate mutase [EC:5.4.99.5]	-0.126	0.191	0.509	0.566
aroB; 3-dehydroquinate synthase [EC:4.2.3.4]	-0.126	0.191	0.509	0.566
aroC; chorismate synthase [EC:4.2.3.5]	-0.126	0.191	0.509	0.566
aroD; 3-dehydroquinate dehydratase I [EC:4.2.1.10]	-0.126	0.191	0.509	0.566
aroE; shikimate dehydrogenase [EC:1.1.1.25]	-0.126	0.191	0.509	0.566
ARSC1, arsC; arsenate reductase [EC:1.20.4.1]	-0.128	0.194	0.510	0.566
asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	-0.126	0.191	0.509	0.566
asnA; aspartate–ammonia ligase [EC:6.3.1.1]	-0.121	0.201	0.548	0.566
asp1; accessory secretory protein Asp1	-0.126	0.191	0.509	0.566
asp2; accessory secretory protein Asp2	-0.126	0.191	0.509	0.566
asp3; accessory secretory protein Asp3	-0.126	0.191	0.509	0.566
aspS; aspartyl-tRNA synthetase [EC:6.1.1.12]	-0.128	0.194	0.510	0.566
ATPF0A, atpB; F-type H+-transporting ATPase subunit a	-0.126	0.191	0.509	0.566
ATPF0B, atpF; F-type H+-transporting ATPase subunit b	-0.126	0.191	0.509	0.566
ATPF0C, atpE; F-type H+-transporting ATPase subunit c	-0.126	0.191	0.509	0.566
ATPF1A, atpA; F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14]	-0.126	0.191	0.509	0.566
ATPF1B, atpD; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14]	-0.126	0.191	0.509	0.566
ATPF1D, atpH; F-type H+-transporting ATPase subunit delta	-0.126	0.191	0.509	0.566
ATPF1E, atpC; F-type H+-transporting ATPase subunit epsilon	-0.126	0.191	0.509	0.566
ATPF1G, atpG; F-type H+-transporting ATPase subunit gamma	-0.126	0.191	0.509	0.566
ATPVA, ntpA, atpA; V/A-type H+/Na+-transporting ATPase subunit A [EC:3.6.3.14 3.6.3.15]	-0.133	0.217	0.540	0.566
ATPVB, ntpB, atpB; V/A-type H+/Na+-transporting ATPase subunit B	-0.133	0.217	0.540	0.566
ATPVC, ntpC, atpC; V/A-type H+/Na+-transporting ATPase subunit C	-0.133	0.217	0.540	0.566
ATPVD, ntpD, atpD; V/A-type H+/Na+-transporting ATPase subunit D	-0.133	0.217	0.540	0.566
ATPVE, ntpE, atpE; V/A-type H+/Na+-transporting ATPase subunit E	-0.133	0.217	0.540	0.566
ATPVF, ntpF, atpF; V/A-type H+/Na+-transporting ATPase subunit F	-0.133	0.217	0.540	0.566
ATPVG, ahaH, atpH; V/A-type H+/Na+-transporting ATPase subunit G/H	-0.335	1.544	0.829	0.829
ATPVI, ntpI, atpI; V/A-type H+/Na+-transporting ATPase subunit I	-0.133	0.217	0.540	0.566
ATPVK, ntpK, atpK; V/A-type H+/Na+-transporting ATPase subunit K	-0.133	0.217	0.540	0.566
bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]	-0.126	0.191	0.509	0.566
bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27]	-0.126	0.191	0.509	0.566
BDH, butB; (R,R)-butanediol dehydrogenase / meso-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.4 1.1.1.- 1.1.1.303]	-0.133	0.217	0.540	0.566
bdhAB; butanol dehydrogenase [EC:1.1.1.-]	-0.133	0.217	0.541	0.566
bgaB, lacA; beta-galactosidase [EC:3.2.1.23]	-0.126	0.191	0.509	0.566
bglG1; transcriptional antiterminator	-0.133	0.217	0.541	0.566
bioY; biotin transport system substrate-specific component	-0.126	0.191	0.509	0.566
birA; BirA family transcriptional regulator, biotin operon repressor / biotin—[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	-0.126	0.191	0.509	0.566
BLMH, pepC; bleomycin hydrolase [EC:3.4.22.40]	-0.126	0.191	0.509	0.566
bmpA, bmpB, tmpC; basic membrane protein A and related proteins	-0.126	0.191	0.509	0.566
butA, budC; meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.- 1.1.1.76 1.1.1.304]	-0.121	0.201	0.547	0.566
cah; cephalosporin-C deacetylase [EC:3.1.1.41]	-0.121	0.201	0.548	0.566
capA, pgsA; gamma-polyglutamate biosynthesis protein CapA	-0.126	0.191	0.509	0.566
carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]	-0.126	0.191	0.509	0.566
carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]	-0.126	0.191	0.509	0.566
CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16]	-0.126	0.191	0.509	0.566
cas1; CRISP-associated protein Cas1	-0.133	0.217	0.541	0.566
cas2; CRISPR-associated protein Cas2	-0.133	0.217	0.541	0.566
cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]	-0.133	0.217	0.541	0.566
catE; catechol 2,3-dioxygenase [EC:1.13.11.2]	-0.126	0.191	0.509	0.566
cbf, cbf1; 3’-5’ exoribonuclease [EC:3.1.-.-]	-0.126	0.191	0.509	0.566
cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]	-0.126	0.191	0.509	0.566
ccdA; cytochrome c-type biogenesis protein	-0.126	0.191	0.509	0.566
cdd, CDA; cytidine deaminase [EC:3.5.4.5]	-0.126	0.191	0.509	0.566
CHO1, pssA; CDP-diacylglycerol—serine O-phosphatidyltransferase [EC:2.7.8.8]	-0.133	0.217	0.540	0.566
ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]	-0.126	0.191	0.509	0.566
ciaR; two-component system, OmpR family, response regulator CiaR	-0.126	0.191	0.509	0.566
cidA; holin-like protein	-0.126	0.191	0.509	0.566
clpC; ATP-dependent Clp protease ATP-binding subunit ClpC	-0.126	0.191	0.509	0.566
clpE; ATP-dependent Clp protease ATP-binding subunit ClpE	-0.126	0.191	0.509	0.566
clpL; ATP-dependent Clp protease ATP-binding subunit ClpL	-0.126	0.191	0.509	0.566
clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]	-0.126	0.191	0.509	0.566
clpX, CLPX; ATP-dependent Clp protease ATP-binding subunit ClpX	-0.126	0.191	0.509	0.566
clsA_B; cardiolipin synthase A/B [EC:2.7.8.-]	-0.126	0.191	0.509	0.566
cmk; CMP/dCMP kinase [EC:2.7.4.25]	-0.126	0.191	0.509	0.566
cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-]	-0.121	0.201	0.548	0.566
coaA; type I pantothenate kinase [EC:2.7.1.33]	-0.126	0.191	0.509	0.566
coaE; dephospho-CoA kinase [EC:2.7.1.24]	-0.126	0.191	0.509	0.566
codY; transcriptional pleiotropic repressor	-0.126	0.191	0.509	0.566
coiA; competence protein CoiA	-0.126	0.191	0.509	0.566
comA; ATP-binding cassette, subfamily C, bacterial, competence factor transporting protein [EC:3.4.22.-]	-0.121	0.201	0.547	0.566
comB; competence factor transport accessory protein ComB	-0.121	0.201	0.547	0.566
comC; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]	-0.126	0.191	0.509	0.566
comD; two-component system, LytTR family, sensor histidine kinase ComD [EC:2.7.13.3]	-0.126	0.191	0.509	0.566
comE; two-component system, LytTR family, response regulator ComE	-0.124	0.191	0.517	0.566
comEA; competence protein ComEA	-0.126	0.191	0.509	0.566
comEB; dCMP deaminase [EC:3.5.4.12]	-0.126	0.191	0.509	0.566
comEC; competence protein ComEC	-0.126	0.191	0.509	0.566
comFA; competence protein ComFA	-0.126	0.191	0.509	0.566
comFC; competence protein ComFC	-0.126	0.191	0.509	0.566
comGA; competence protein ComGA	-0.126	0.191	0.509	0.566
comGB; competence protein ComGB	-0.126	0.191	0.509	0.566
comGC; competence protein ComGC	-0.126	0.191	0.509	0.566
comGD; competence protein ComGD	-0.126	0.191	0.509	0.566
comGF; competence protein ComGF	-0.126	0.191	0.509	0.566
comX1_2; competence protein ComX	-0.124	0.191	0.517	0.566
copA, ATP7; Cu+-exporting ATPase [EC:3.6.3.54]	-0.126	0.191	0.509	0.566
corA; magnesium transporter	-0.126	0.191	0.509	0.566
cotH; spore coat protein H	-0.335	1.544	0.829	0.829
cpdB; 2’,3’-cyclic-nucleotide 2’-phosphodiesterase / 3’-nucleotidase [EC:3.1.4.16 3.1.3.6]	-0.133	0.217	0.541	0.566
cpoA; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-galactosyltransferase [EC:2.4.1.-]	-0.121	0.201	0.548	0.566
crcB, FEX; fluoride exporter	-0.126	0.191	0.509	0.566
CS, gltA; citrate synthase [EC:2.3.3.1]	-0.133	0.217	0.540	0.566
cshB; ATP-dependent RNA helicase CshB [EC:3.6.4.13]	-0.126	0.191	0.509	0.566
csn1, cas9; CRISPR-associated endonuclease Csn1 [EC:3.1.-.-]	-0.133	0.217	0.541	0.566
ctpE; cation-transporting P-type ATPase E [EC:3.6.3.-]	-0.126	0.191	0.509	0.566
ctsR; transcriptional regulator of stress and heat shock response	-0.126	0.191	0.509	0.566
cutC; copper homeostasis protein	-0.126	0.191	0.509	0.566
cycB, ganO; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein	-0.126	0.191	0.509	0.566
cynT, can; carbonic anhydrase [EC:4.2.1.1]	-0.126	0.191	0.509	0.566
cysE; serine O-acetyltransferase [EC:2.3.1.30]	-0.126	0.191	0.509	0.566
cysK; cysteine synthase A [EC:2.5.1.47]	-0.126	0.191	0.509	0.566
czcD, zitB; cobalt-zinc-cadmium efflux system protein	-0.126	0.191	0.509	0.566
dacA; diadenylate cyclase [EC:2.7.7.85]	-0.126	0.191	0.509	0.566
dacC, dacA, dacD; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]	-0.126	0.191	0.509	0.566
dagK; diacylglycerol kinase (ATP) [EC:2.7.1.107]	-0.133	0.217	0.540	0.566
DAK, TKFC; triose/dihydroxyacetone kinase / FAD-AMP lyase (cyclizing) [EC:2.7.1.28 2.7.1.29 4.6.1.15]	-0.121	0.201	0.548	0.566
dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]	-0.126	0.191	0.509	0.566
dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	-0.128	0.194	0.510	0.566
dapD; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [EC:2.3.1.117]	-0.126	0.191	0.509	0.566
dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]	-0.126	0.191	0.509	0.566
dapL; N-acetyldiaminopimelate deacetylase [EC:3.5.1.47]	-0.126	0.191	0.509	0.566
ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]	-0.124	0.191	0.517	0.566
deaD, cshA; ATP-dependent RNA helicase DeaD [EC:3.6.4.13]	-0.126	0.191	0.509	0.566
degP, htrA; serine protease Do [EC:3.4.21.107]	-0.126	0.191	0.509	0.566
deoB; phosphopentomutase [EC:5.4.2.7]	-0.126	0.191	0.509	0.566
deoC, DERA; deoxyribose-phosphate aldolase [EC:4.1.2.4]	-0.126	0.191	0.509	0.566
deoD; purine-nucleoside phosphorylase [EC:2.4.2.1]	-0.126	0.191	0.509	0.566
desK; two-component system, NarL family, sensor histidine kinase DesK [EC:2.7.13.3]	-0.126	0.191	0.509	0.566
dexB; glucan 1,6-alpha-glucosidase [EC:3.2.1.70]	-0.121	0.201	0.548	0.566
dgkA; undecaprenol kinase [EC:2.7.1.66]	-0.126	0.191	0.509	0.566
dgs, bgsA; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-glucosyltransferase [EC:2.4.1.208]	-0.133	0.217	0.540	0.566
dhaK; phosphoenolpyruvate—glycerone phosphotransferase subunit DhaK [EC:2.7.1.121]	-0.121	0.201	0.548	0.566
dhaL; phosphoenolpyruvate—glycerone phosphotransferase subunit DhaL [EC:2.7.1.121]	-0.126	0.191	0.510	0.566
DHFR, folA; dihydrofolate reductase [EC:1.5.1.3]	-0.126	0.191	0.509	0.566
dinB; DNA polymerase IV [EC:2.7.7.7]	-0.126	0.191	0.509	0.566
dinG; ATP-dependent DNA helicase DinG [EC:3.6.4.12]	-0.126	0.191	0.509	0.566
dinJ; DNA-damage-inducible protein J	-0.126	0.191	0.509	0.566
divIC, divA; cell division protein DivIC	-0.126	0.191	0.509	0.566
divIVA; cell division initiation protein	-0.126	0.191	0.509	0.566
DLAT, aceF, pdhC; pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) [EC:2.3.1.12]	-0.126	0.191	0.509	0.566
DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4]	-0.126	0.191	0.509	0.566
dltA; D-alanine–poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13]	-0.126	0.191	0.509	0.566
dltB; membrane protein involved in D-alanine export	-0.126	0.191	0.509	0.566
dltC; D-alanine–poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13]	-0.126	0.191	0.509	0.566
dltD; D-alanine transfer protein	-0.126	0.191	0.509	0.566
dnaA; chromosomal replication initiator protein	-0.126	0.191	0.509	0.566
dnaB; replication initiation and membrane attachment protein	-0.126	0.191	0.509	0.566
dnaB; replicative DNA helicase [EC:3.6.4.12]	-0.126	0.191	0.509	0.566
dnaD; DNA replication protein	-0.126	0.191	0.509	0.566
dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	-0.126	0.191	0.509	0.566
dnaG; DNA primase [EC:2.7.7.-]	-0.126	0.191	0.509	0.566
dnaI; primosomal protein DnaI	-0.126	0.191	0.509	0.566
dnaJ; molecular chaperone DnaJ	-0.126	0.191	0.509	0.566
dnaK, HSPA9; molecular chaperone DnaK	-0.126	0.191	0.509	0.566
dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]	-0.126	0.191	0.509	0.566
dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]	-0.121	0.201	0.548	0.566
dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]	-0.126	0.191	0.509	0.566
DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]	-0.121	0.200	0.546	0.566
doc; death on curing protein	-0.121	0.201	0.548	0.566
DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83]	-0.121	0.201	0.548	0.566
dps; starvation-inducible DNA-binding protein	-0.126	0.191	0.509	0.566
dtd, DTD1; D-tyrosyl-tRNA(Tyr) deacylase [EC:3.1.-.-]	-0.126	0.191	0.509	0.566
dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23]	-0.126	0.191	0.509	0.566
E1.1.1.1, adh; alcohol dehydrogenase [EC:1.1.1.1]	-0.133	0.217	0.540	0.566
E1.1.1.3; homoserine dehydrogenase [EC:1.1.1.3]	-0.126	0.191	0.509	0.566
E1.1.3.21; alpha-glycerophosphate oxidase [EC:1.1.3.21]	-0.126	0.191	0.509	0.566
E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]	-0.126	0.191	0.509	0.566
E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]	-0.126	0.191	0.509	0.566
E1.2.3.3, poxL; pyruvate oxidase [EC:1.2.3.3]	-0.126	0.191	0.509	0.566
E1.4.1.4, gdhA; glutamate dehydrogenase (NADP+) [EC:1.4.1.4]	-0.128	0.194	0.510	0.566
E1.7.1.7, guaC; GMP reductase [EC:1.7.1.7]	-0.126	0.191	0.509	0.566
E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72]	-0.128	0.194	0.510	0.566
E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	-0.123	0.193	0.524	0.566
E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	-0.126	0.191	0.509	0.566
E2.2.1.6S, ilvH, ilvN; acetolactate synthase I/III small subunit [EC:2.2.1.6]	-0.126	0.191	0.509	0.566
E2.3.1.54, pflD; formate C-acetyltransferase [EC:2.3.1.54]	-0.128	0.194	0.510	0.566
E2.3.1.8, pta; phosphate acetyltransferase [EC:2.3.1.8]	-0.126	0.191	0.509	0.566
E2.3.3.10; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10]	-0.126	0.191	0.509	0.566
E2.4.-.-; glycosyltransferase [EC:2.4.-.-]	-0.133	0.217	0.540	0.566
E2.4.1.5; dextransucrase [EC:2.4.1.5]	-0.133	0.217	0.540	0.566
E2.4.1.7; sucrose phosphorylase [EC:2.4.1.7]	-0.133	0.217	0.541	0.566
E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	-0.126	0.191	0.510	0.566
E2.6.1.11, argD; acetylornithine aminotransferase [EC:2.6.1.11]	-0.133	0.217	0.539	0.566
E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42]	-0.126	0.191	0.509	0.566
E2.7.1.36, MVK, mvaK1; mevalonate kinase [EC:2.7.1.36]	-0.126	0.191	0.509	0.566
E2.7.1.4, scrK; fructokinase [EC:2.7.1.4]	-0.133	0.217	0.540	0.566
E2.7.1.71, aroK, aroL; shikimate kinase [EC:2.7.1.71]	-0.126	0.191	0.509	0.566
E2.7.13.3; histidine kinase [EC:2.7.13.3]	-0.121	0.201	0.548	0.566
E2.7.4.2, mvaK2; phosphomevalonate kinase [EC:2.7.4.2]	-0.126	0.191	0.509	0.566
E2.7.4.8, gmk; guanylate kinase [EC:2.7.4.8]	-0.126	0.191	0.509	0.566
E2.7.6.5X; putative GTP pyrophosphokinase [EC:2.7.6.5]	-0.126	0.191	0.509	0.566
E2.7.7.24, rfbA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]	-0.133	0.217	0.540	0.566
E2.7.7.3A, coaD, kdtB; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]	-0.126	0.191	0.509	0.566
E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	-0.126	0.191	0.509	0.566
E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2]	-0.126	0.191	0.509	0.566
E3.1.3.15B; histidinol-phosphatase (PHP family) [EC:3.1.3.15]	-0.133	0.217	0.540	0.566
E3.1.3.16; protein phosphatase [EC:3.1.3.16]	-0.126	0.191	0.509	0.566
E3.1.3.25, IMPA, suhB; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]	-0.126	0.191	0.509	0.566
E3.1.3.41; 4-nitrophenyl phosphatase [EC:3.1.3.41]	-0.126	0.191	0.509	0.566
E3.1.3.48; protein-tyrosine phosphatase [EC:3.1.3.48]	-0.128	0.194	0.510	0.566
E3.1.3.5; 5’-nucleotidase [EC:3.1.3.5]	-0.133	0.217	0.540	0.566
E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]	-0.126	0.191	0.509	0.566
E3.2.1.22B, galA, rafA; alpha-galactosidase [EC:3.2.1.22]	-0.133	0.217	0.541	0.566
E3.2.1.85, lacG; 6-phospho-beta-galactosidase [EC:3.2.1.85]	-0.126	0.191	0.509	0.566
E3.2.1.86B, bglA; 6-phospho-beta-glucosidase [EC:3.2.1.86]	-0.129	0.198	0.514	0.566
E3.2.1.96; mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase [EC:3.2.1.96]	-0.121	0.201	0.548	0.566
E3.4.13.-; D-alanyl-D-alanine dipeptidase [EC:3.4.13.-]	-0.126	0.191	0.509	0.566
E3.4.16.4; D-alanyl-D-alanine carboxypeptidase [EC:3.4.16.4]	-0.133	0.217	0.540	0.566
E3.4.21.96; lactocepin [EC:3.4.21.96]	-0.134	0.217	0.538	0.566
E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	-0.126	0.191	0.509	0.566
E3.6.3.8; Ca2+-transporting ATPase [EC:3.6.3.8]	-0.126	0.191	0.509	0.566
E4.1.1.18, ldcC, cadA; lysine decarboxylase [EC:4.1.1.18]	-0.121	0.201	0.548	0.566
E4.1.1.19; arginine decarboxylase [EC:4.1.1.19]	-0.121	0.201	0.548	0.566
E4.1.1.49, pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]	-0.133	0.217	0.541	0.566
E4.1.3.3, nanA, NPL; N-acetylneuraminate lyase [EC:4.1.3.3]	-0.126	0.191	0.509	0.566
E4.2.1.46, rfbB, rffG; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]	-0.133	0.217	0.540	0.566
E4.3.1.17, sdaA, sdaB, tdcG; L-serine dehydratase [EC:4.3.1.17]	-0.126	0.191	0.509	0.566
E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	-0.126	0.191	0.509	0.566
E4.3.1.4; formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4]	-0.133	0.217	0.540	0.566
E4.6.1.1B, cyaB; adenylate cyclase, class 2 [EC:4.6.1.1]	-0.121	0.201	0.548	0.566
E5.3.1.26, lacA, lacB; galactose-6-phosphate isomerase [EC:5.3.1.26]	-0.124	0.191	0.517	0.566
E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]	-0.126	0.191	0.509	0.566
ecfA1; energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-]	-0.126	0.191	0.509	0.566
ecfA2; energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-]	-0.125	0.191	0.513	0.566
ecfT; energy-coupling factor transport system permease protein	-0.125	0.191	0.512	0.566
efeB; deferrochelatase/peroxidase EfeB [EC:1.11.1.-]	-0.133	0.217	0.540	0.566
efeO; iron uptake system component EfeO	-0.133	0.217	0.540	0.566
efp; elongation factor P	-0.126	0.191	0.509	0.566
efrA; ATP-binding cassette, subfamily B, multidrug efflux pump	-0.133	0.217	0.540	0.566
efrB; ATP-binding cassette, subfamily B, multidrug efflux pump	-0.133	0.217	0.540	0.566
elaA; ElaA protein	-0.133	0.217	0.540	0.566
emrE, qac, mmr, smr; small multidrug resistance pump	-0.335	1.544	0.829	0.829
endA; DNA-entry nuclease	-0.126	0.191	0.509	0.566
engA, der; GTPase	-0.126	0.191	0.509	0.566
engB; GTP-binding protein	-0.126	0.191	0.509	0.566
ENO, eno; enolase [EC:4.2.1.11]	-0.126	0.191	0.509	0.566
era, ERAL1; GTPase	-0.126	0.191	0.509	0.566
estA; putative tributyrin esterase [EC:3.1.1.-]	-0.126	0.191	0.509	0.566
eta; exfoliative toxin A/B	-0.126	0.191	0.509	0.566
ezrA; septation ring formation regulator	-0.126	0.191	0.509	0.566
fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]	-0.126	0.191	0.509	0.566
fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]	-0.126	0.191	0.509	0.566
fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]	-0.126	0.191	0.509	0.566
fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]	-0.126	0.191	0.509	0.566
fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]	-0.126	0.191	0.509	0.566
fabM; trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:5.3.3.14]	-0.126	0.191	0.509	0.566
fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]	-0.126	0.191	0.509	0.566
FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]	-0.126	0.191	0.509	0.566
FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]	-0.126	0.191	0.509	0.566
FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	-0.126	0.191	0.509	0.566
fbp3; fructose-1,6-bisphosphatase III [EC:3.1.3.11]	-0.133	0.217	0.541	0.566
fctD; glutamate formiminotransferase [EC:2.1.2.5]	-0.133	0.217	0.540	0.566
fer; ferredoxin	-0.126	0.191	0.509	0.566
fhs; formate–tetrahydrofolate ligase [EC:6.3.4.3]	-0.128	0.194	0.510	0.566
flA; adenosyl-fluoride synthase [EC:2.5.1.63]	-0.126	0.191	0.509	0.566
FLOT; flotillin	-0.133	0.217	0.540	0.566
folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]	-0.126	0.191	0.509	0.566
folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]	-0.126	0.191	0.509	0.566
folP; dihydropteroate synthase [EC:2.5.1.15]	-0.126	0.191	0.509	0.566
frr, MRRF, RRF; ribosome recycling factor	-0.126	0.191	0.509	0.566
fruA; fructan beta-fructosidase [EC:3.2.1.80]	-0.133	0.217	0.540	0.566
fruK; 1-phosphofructokinase [EC:2.7.1.56]	-0.126	0.191	0.509	0.566
fruR2, fruR; DeoR family transcriptional regulator, fructose operon transcriptional repressor	-0.126	0.191	0.509	0.566
FTR, FTH1, efeU; high-affinity iron transporter	-0.133	0.217	0.540	0.566
ftsA; cell division protein FtsA	-0.126	0.191	0.509	0.566
ftsE; cell division transport system ATP-binding protein	-0.126	0.191	0.509	0.566
ftsH, hflB; cell division protease FtsH [EC:3.4.24.-]	-0.126	0.191	0.509	0.566
ftsK, spoIIIE; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family	-0.128	0.194	0.510	0.566
ftsQ; cell division protein FtsQ	-0.126	0.191	0.509	0.566
ftsW, spoVE; cell division protein FtsW	-0.126	0.191	0.509	0.566
ftsX; cell division transport system permease protein	-0.126	0.191	0.509	0.566
ftsY; fused signal recognition particle receptor	-0.126	0.191	0.509	0.566
ftsZ; cell division protein FtsZ	-0.126	0.191	0.509	0.566
FUCA; alpha-L-fucosidase [EC:3.2.1.51]	-0.121	0.200	0.546	0.566
fusA, GFM, EFG; elongation factor G	-0.126	0.191	0.509	0.566
G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	-0.126	0.191	0.509	0.566
galE, GALE; UDP-glucose 4-epimerase [EC:5.1.3.2]	-0.126	0.191	0.509	0.566
galK; galactokinase [EC:2.7.1.6]	-0.126	0.191	0.509	0.566
galM, GALM; aldose 1-epimerase [EC:5.1.3.3]	-0.126	0.191	0.509	0.566
galT, GALT; UDPglucose–hexose-1-phosphate uridylyltransferase [EC:2.7.7.12]	-0.126	0.191	0.509	0.566
ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein	-0.124	0.191	0.517	0.566
ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein	-0.126	0.191	0.509	0.566
GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]	-0.126	0.191	0.509	0.566
gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9]	-0.133	0.217	0.541	0.566
gatA, QRSL1; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]	-0.126	0.191	0.509	0.566
gatB, PET112; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]	-0.126	0.191	0.509	0.566
gatC, GATC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]	-0.126	0.191	0.509	0.566
GBE1, glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]	-0.126	0.191	0.509	0.566
GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16]	-0.126	0.191	0.509	0.566
GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]	-0.126	0.191	0.509	0.566
gidA, mnmG, MTO1; tRNA uridine 5-carboxymethylaminomethyl modification enzyme	-0.126	0.191	0.509	0.566
gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]	-0.126	0.191	0.509	0.566
gldA; glycerol dehydrogenase [EC:1.1.1.6]	-0.133	0.217	0.541	0.566
glf; UDP-galactopyranose mutase [EC:5.4.99.9]	-0.335	1.544	0.829	0.829
glgA; starch synthase [EC:2.4.1.21]	-0.126	0.191	0.509	0.566
glgC; glucose-1-phosphate adenylyltransferase [EC:2.7.7.27]	-0.126	0.191	0.509	0.566
glk; glucokinase [EC:2.7.1.2]	-0.126	0.191	0.509	0.566
glmM; phosphoglucosamine mutase [EC:5.4.2.10]	-0.126	0.191	0.509	0.566
glmS, GFPT; glucosamine—fructose-6-phosphate aminotransferase (isomerizing) [EC:2.6.1.16]	-0.126	0.191	0.509	0.566
glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]	-0.126	0.191	0.509	0.566
glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	-0.126	0.191	0.509	0.566
glnR; MerR family transcriptional regulator, glutamine synthetase repressor	-0.126	0.191	0.509	0.566
GLO1, gloA; lactoylglutathione lyase [EC:4.4.1.5]	-0.126	0.191	0.509	0.566
gloB, HAGH; hydroxyacylglutathione hydrolase [EC:3.1.2.6]	-0.335	1.544	0.829	0.829
GLPF; glycerol uptake facilitator protein	-0.126	0.191	0.509	0.566
glpK, GK; glycerol kinase [EC:2.7.1.30]	-0.126	0.191	0.509	0.566
gltP, gltT; proton glutamate symport protein	-0.133	0.217	0.540	0.566
gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24]	-0.126	0.191	0.509	0.566
glxK, garK; glycerate 2-kinase [EC:2.7.1.165]	-0.126	0.191	0.509	0.566
glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1]	-0.126	0.191	0.509	0.566
glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]	-0.126	0.191	0.509	0.566
glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]	-0.126	0.191	0.509	0.566
gph; phosphoglycolate phosphatase [EC:3.1.3.18]	-0.126	0.191	0.509	0.566
GPI, pgi; glucose-6-phosphate isomerase [EC:5.3.1.9]	-0.126	0.191	0.509	0.566
gpmB; probable phosphoglycerate mutase [EC:5.4.2.12]	-0.129	0.196	0.512	0.566
gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]	-0.126	0.191	0.509	0.566
gpx; glutathione peroxidase [EC:1.11.1.9]	-0.126	0.191	0.509	0.566
greA; transcription elongation factor GreA	-0.126	0.191	0.509	0.566
groEL, HSPD1; chaperonin GroEL	-0.126	0.191	0.509	0.566
groES, HSPE1; chaperonin GroES	-0.126	0.191	0.509	0.566
GRPE; molecular chaperone GrpE	-0.126	0.191	0.509	0.566
gshA; glutamate–cysteine ligase [EC:6.3.2.2]	-0.133	0.217	0.540	0.566
GSP13; general stress protein 13	-0.126	0.191	0.509	0.566
GSR, gor; glutathione reductase (NADPH) [EC:1.8.1.7]	-0.126	0.191	0.509	0.566
guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	-0.126	0.191	0.509	0.566
gyrA; DNA gyrase subunit A [EC:5.99.1.3]	-0.126	0.191	0.509	0.566
gyrB; DNA gyrase subunit B [EC:5.99.1.3]	-0.126	0.191	0.509	0.566
HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21]	-0.126	0.191	0.509	0.566
hemE, UROD; uroporphyrinogen decarboxylase [EC:4.1.1.37]	-0.121	0.201	0.548	0.566
hemH, FECH; protoporphyrin/coproporphyrin ferrochelatase [EC:4.99.1.1 4.99.1.9]	-0.126	0.191	0.509	0.566
hemK, prmC, HEMK; release factor glutamine methyltransferase [EC:2.1.1.297]	-0.126	0.191	0.509	0.566
hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	-0.126	0.191	0.509	0.566
HEXA_B; hexosaminidase [EC:3.2.1.52]	-0.133	0.217	0.539	0.566
hflX; GTPase	-0.126	0.191	0.509	0.566
higB-1; toxin HigB-1	-0.133	0.217	0.541	0.566
HINT1, hinT, hit; histidine triad (HIT) family protein	-0.126	0.191	0.509	0.566
hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16]	-0.133	0.217	0.540	0.566
hisB; imidazoleglycerol-phosphate dehydratase [EC:4.2.1.19]	-0.133	0.217	0.540	0.566
hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]	-0.133	0.217	0.540	0.566
hisD; histidinol dehydrogenase [EC:1.1.1.23]	-0.133	0.217	0.540	0.566
hisE; phosphoribosyl-ATP pyrophosphohydrolase [EC:3.6.1.31]	-0.133	0.217	0.540	0.566
hisF; cyclase [EC:4.1.3.-]	-0.133	0.217	0.540	0.566
hisG; ATP phosphoribosyltransferase [EC:2.4.2.17]	-0.133	0.217	0.540	0.566
hisH; glutamine amidotransferase [EC:2.4.2.-]	-0.133	0.217	0.540	0.566
hisI; phosphoribosyl-AMP cyclohydrolase [EC:3.5.4.19]	-0.133	0.217	0.540	0.566
hisZ; ATP phosphoribosyltransferase regulatory subunit	-0.133	0.217	0.540	0.566
hlyIII; hemolysin III	-0.126	0.191	0.509	0.566
holA; DNA polymerase III subunit delta [EC:2.7.7.7]	-0.126	0.191	0.509	0.566
holB; DNA polymerase III subunit delta’ [EC:2.7.7.7]	-0.126	0.191	0.509	0.566
hprK, ptsK; HPr kinase/phosphorylase [EC:2.7.11.- 2.7.4.-]	-0.126	0.191	0.509	0.566
hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]	-0.126	0.191	0.509	0.566
hrcA; heat-inducible transcriptional repressor	-0.126	0.191	0.509	0.566
hsdM; type I restriction enzyme M protein [EC:2.1.1.72]	-0.128	0.194	0.511	0.566
hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]	-0.128	0.194	0.511	0.566
hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]	-0.127	0.192	0.509	0.566
hslO; molecular chaperone Hsp33	-0.126	0.191	0.509	0.566
htpX; heat shock protein HtpX [EC:3.4.24.-]	-0.126	0.191	0.509	0.566
htsT; energy-coupling factor transport system substrate-specific component	-0.126	0.191	0.509	0.566
hupB; DNA-binding protein HU-beta	-0.126	0.191	0.509	0.566
hutG; formiminoglutamase [EC:3.5.3.8]	-0.133	0.217	0.540	0.566
hutH, HAL; histidine ammonia-lyase [EC:4.3.1.3]	-0.133	0.217	0.540	0.566
hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7]	-0.133	0.217	0.540	0.566
hutU, UROC1; urocanate hydratase [EC:4.2.1.49]	-0.133	0.217	0.540	0.566
IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5]	-0.126	0.191	0.509	0.566
IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	-0.133	0.217	0.540	0.566
idi, IDI; isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2]	-0.126	0.191	0.509	0.566
ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3]	-0.133	0.217	0.540	0.566
ilvC; ketol-acid reductoisomerase [EC:1.1.1.86]	-0.126	0.191	0.509	0.566
ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	-0.126	0.191	0.509	0.566
IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205]	-0.126	0.191	0.509	0.566
infA; translation initiation factor IF-1	-0.126	0.191	0.509	0.566
infB, MTIF2; translation initiation factor IF-2	-0.126	0.191	0.509	0.566
infC, MTIF3; translation initiation factor IF-3	-0.126	0.191	0.509	0.566
INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	-0.126	0.191	0.509	0.566
irr; two-component system, OmpR family, response regulator Irr	-0.133	0.217	0.540	0.566
iscS, NFS1; cysteine desulfurase [EC:2.8.1.7]	-0.126	0.191	0.509	0.566
iscU, nifU; nitrogen fixation protein NifU and related proteins	-0.126	0.191	0.509	0.566
ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60]	-0.121	0.201	0.548	0.566
jag; spoIIIJ-associated protein	-0.126	0.191	0.509	0.566
K00243; uncharacterized protein	-0.126	0.191	0.509	0.566
K01436; amidohydrolase [EC:3.5.1.-]	-0.133	0.217	0.540	0.566
K03710; GntR family transcriptional regulator	-0.126	0.191	0.509	0.566
K06871; uncharacterized protein	-0.133	0.217	0.541	0.566
K06878; tRNA-binding protein	-0.126	0.191	0.509	0.566
K06885; uncharacterized protein	-0.126	0.191	0.509	0.566
K06889; uncharacterized protein	-0.133	0.217	0.540	0.566
K06890; uncharacterized protein	-0.126	0.191	0.509	0.566
K06915; uncharacterized protein	-0.121	0.201	0.548	0.566
K06929; uncharacterized protein	-0.126	0.191	0.509	0.566
K06940; uncharacterized protein	-0.126	0.191	0.509	0.566
K06950; uncharacterized protein	-0.133	0.217	0.540	0.566
K06960; uncharacterized protein	-0.126	0.191	0.509	0.566
K06962; uncharacterized protein	-0.133	0.217	0.541	0.566
K07004; uncharacterized protein	-0.133	0.217	0.540	0.566
K07007; uncharacterized protein	-0.124	0.191	0.517	0.566
K07009; uncharacterized protein	-0.126	0.191	0.509	0.566
K07010; putative glutamine amidotransferase	-0.126	0.191	0.510	0.566
K07015; uncharacterized protein	-0.126	0.191	0.509	0.566
K07023; putative hydrolases of HD superfamily	-0.133	0.217	0.540	0.566
K07025; putative hydrolase of the HAD superfamily	-0.129	0.198	0.514	0.566
K07030; uncharacterized protein	-0.126	0.191	0.509	0.566
K07040; uncharacterized protein	-0.126	0.191	0.509	0.566
K07052; uncharacterized protein	-0.126	0.191	0.510	0.566
K07054; uncharacterized protein	-0.335	1.544	0.829	0.829
K07058; membrane protein	-0.126	0.191	0.509	0.566
K07078; uncharacterized protein	-0.335	1.544	0.829	0.829
K07082; UPF0755 protein	-0.126	0.191	0.509	0.566
K07088; uncharacterized protein	-0.335	1.544	0.829	0.829
K07089; uncharacterized protein	-0.126	0.191	0.509	0.566
K07095; uncharacterized protein	-0.126	0.191	0.509	0.566
K07105; uncharacterized protein	-0.126	0.191	0.509	0.566
K07124; uncharacterized protein	-0.126	0.191	0.509	0.566
K07133; uncharacterized protein	-0.121	0.201	0.548	0.566
K07139; uncharacterized protein	-0.126	0.191	0.509	0.566
K07146; UPF0176 protein	-0.126	0.191	0.509	0.566
K07166; ACT domain-containing protein	-0.126	0.191	0.509	0.566
K07177; Lon-like protease	-0.126	0.191	0.509	0.566
K07461; putative endonuclease	-0.126	0.191	0.509	0.566
K07485; transposase	-0.121	0.201	0.547	0.566
K07491; putative transposase	-0.121	0.201	0.548	0.566
K07498; putative transposase	-0.335	1.544	0.829	0.829
K07727; putative transcriptional regulator	-0.133	0.217	0.540	0.566
K07729; putative transcriptional regulator	-0.128	0.193	0.509	0.566
K08303; putative protease [EC:3.4.-.-]	-0.126	0.191	0.509	0.566
K08884; serine/threonine protein kinase, bacterial [EC:2.7.11.1]	-0.126	0.191	0.509	0.566
K08974; putative membrane protein	-0.126	0.191	0.509	0.566
K08987; putative membrane protein	-0.126	0.191	0.509	0.566
K08998; uncharacterized protein	-0.126	0.191	0.509	0.566
K09153; uncharacterized protein	-0.133	0.217	0.540	0.566
K09155; uncharacterized protein	-0.126	0.191	0.509	0.566
K09157; uncharacterized protein	-0.126	0.191	0.509	0.566
K09384; uncharacterized protein	-0.335	1.544	0.829	0.829
K09704; uncharacterized protein	-0.121	0.201	0.547	0.566
K09747; uncharacterized protein	-0.126	0.191	0.509	0.566
K09762; uncharacterized protein	-0.126	0.191	0.509	0.566
K09787; uncharacterized protein	-0.126	0.191	0.509	0.566
K09790; uncharacterized protein	-0.126	0.191	0.509	0.566
K09861; uncharacterized protein	-0.126	0.191	0.509	0.566
K09962; uncharacterized protein	-0.126	0.191	0.509	0.566
K09976; uncharacterized protein	-0.126	0.191	0.509	0.566
K10120, msmE; fructooligosaccharide transport system substrate-binding protein	-0.335	1.544	0.829	0.829
K10121, msmF; fructooligosaccharide transport system permease protein	-0.335	1.544	0.829	0.829
K10122, msmG; fructooligosaccharide transport system permease protein	-0.335	1.544	0.829	0.829
K11145; ribonuclease III family protein [EC:3.1.26.-]	-0.126	0.191	0.509	0.566
K13653; AraC family transcriptional regulator	-0.133	0.217	0.540	0.566
K17076, lysY; putative lysine transport system ATP-binding protein [EC:3.6.3.-]	-0.126	0.191	0.509	0.566
K17318, lplA; putative aldouronate transport system substrate-binding protein	-0.124	0.191	0.517	0.566
KAE1, tsaD, QRI7; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]	-0.128	0.194	0.510	0.566
KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]	-0.126	0.191	0.509	0.566
kch, trkA, mthK, pch; voltage-gated potassium channel	-0.126	0.191	0.509	0.566
ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]	-0.126	0.191	0.509	0.566
lacC; tagatose 6-phosphate kinase [EC:2.7.1.144]	-0.126	0.191	0.509	0.566
lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40]	-0.126	0.191	0.509	0.566
lacI, galR; LacI family transcriptional regulator	-0.126	0.191	0.509	0.566
lacR; DeoR family transcriptional regulator, lactose phosphotransferase system repressor	-0.128	0.194	0.510	0.566
lacT; transcriptional antiterminator	-0.126	0.191	0.509	0.566
lacY; MFS transporter, OHS family, lactose permease	-0.133	0.217	0.540	0.566
lacZ; beta-galactosidase [EC:3.2.1.23]	-0.133	0.217	0.540	0.566
LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4]	-0.126	0.191	0.509	0.566
lctO; L-lactate oxidase [EC:1.1.3.2]	-0.121	0.201	0.547	0.566
LDH, ldh; L-lactate dehydrogenase [EC:1.1.1.27]	-0.126	0.191	0.509	0.566
lemA; LemA protein	-0.126	0.191	0.509	0.566
lepA; GTP-binding protein LepA	-0.126	0.191	0.509	0.566
lepB; signal peptidase I [EC:3.4.21.89]	-0.128	0.194	0.510	0.566
leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	-0.126	0.191	0.509	0.566
leuB, IMDH; 3-isopropylmalate dehydrogenase [EC:1.1.1.85]	-0.126	0.191	0.509	0.566
leuC, IPMI-L; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]	-0.126	0.191	0.509	0.566
leuD, IPMI-S; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]	-0.126	0.191	0.509	0.566
lgt, umpA; phosphatidylglycerol:prolipoprotein diacylglycerol transferase [EC:2.-.-.-]	-0.126	0.191	0.509	0.566
liaR; two-component system, NarL family, response regulator LiaR	-0.126	0.191	0.509	0.566
liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3]	-0.126	0.191	0.509	0.566
licD; lipopolysaccharide cholinephosphotransferase [EC:2.7.8.-]	-0.121	0.201	0.548	0.566
licR; lichenan operon transcriptional antiterminator	-0.133	0.217	0.540	0.566
licT, bglG; beta-glucoside operon transcriptional antiterminator	-0.133	0.217	0.540	0.566
livF; branched-chain amino acid transport system ATP-binding protein	-0.126	0.191	0.509	0.566
livG; branched-chain amino acid transport system ATP-binding protein	-0.126	0.191	0.509	0.566
livH; branched-chain amino acid transport system permease protein	-0.126	0.191	0.509	0.566
livK; branched-chain amino acid transport system substrate-binding protein	-0.126	0.191	0.509	0.566
livM; branched-chain amino acid transport system permease protein	-0.126	0.191	0.509	0.566
lplA, lplJ; lipoate—protein ligase [EC:6.3.1.20]	-0.126	0.191	0.509	0.566
lplB; putative aldouronate transport system permease protein	-0.124	0.191	0.517	0.566
lplC; putative aldouronate transport system permease protein	-0.124	0.191	0.517	0.566
lspA; signal peptidase II [EC:3.4.23.36]	-0.126	0.191	0.509	0.566
ltaE; threonine aldolase [EC:4.1.2.48]	-0.335	1.544	0.829	0.829
ltaS; lipoteichoic acid synthase [EC:2.7.8.20]	-0.133	0.217	0.540	0.566
luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21]	-0.126	0.191	0.509	0.566
LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7]	-0.121	0.201	0.548	0.566
lysA; diaminopimelate decarboxylase [EC:4.1.1.20]	-0.126	0.191	0.509	0.566
lysC; aspartate kinase [EC:2.7.2.4]	-0.126	0.191	0.509	0.566
lysX2; putative lysine transport system permease protein	-0.126	0.191	0.509	0.566
maa; maltose O-acetyltransferase [EC:2.3.1.79]	-0.126	0.191	0.509	0.566
malQ; 4-alpha-glucanotransferase [EC:2.4.1.25]	-0.126	0.191	0.509	0.566
MAN2C1; alpha-mannosidase [EC:3.2.1.24]	-0.121	0.201	0.547	0.566
manA, MPI; mannose-6-phosphate isomerase [EC:5.3.1.8]	-0.126	0.191	0.509	0.566
map; methionyl aminopeptidase [EC:3.4.11.18]	-0.126	0.191	0.509	0.566
mapP; maltose 6’-phosphate phosphatase [EC:3.1.3.90]	-0.126	0.191	0.509	0.566
MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]	-0.126	0.191	0.509	0.566
MCH; medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21]	-0.126	0.191	0.509	0.566
ME2, sfcA, maeA; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]	-0.335	1.544	0.829	0.829
mecA1_2; adapter protein MecA 1/2	-0.126	0.191	0.509	0.566
metA; homoserine O-succinyltransferase/O-acetyltransferase [EC:2.3.1.46 2.3.1.31]	-0.126	0.191	0.509	0.566
metB; cystathionine gamma-synthase [EC:2.5.1.48]	-0.126	0.191	0.509	0.566
metE; 5-methyltetrahydropteroyltriglutamate–homocysteine methyltransferase [EC:2.1.1.14]	-0.126	0.191	0.509	0.566
metF, MTHFR; methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]	-0.126	0.191	0.509	0.566
metI; D-methionine transport system permease protein	-0.124	0.191	0.517	0.566
metK; S-adenosylmethionine synthetase [EC:2.5.1.6]	-0.126	0.191	0.509	0.566
metN; D-methionine transport system ATP-binding protein	-0.126	0.191	0.509	0.566
metQ; D-methionine transport system substrate-binding protein	-0.126	0.191	0.509	0.566
metY; O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49]	-0.126	0.191	0.509	0.566
mfd; transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-]	-0.126	0.191	0.509	0.566
MFS.CP; MFS transporter, CP family, cyanate transporter	-0.126	0.191	0.509	0.566
mgs, bgsB; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]	-0.126	0.191	0.509	0.566
mgtA, mgtB; Mg2+-importing ATPase [EC:3.6.3.2]	-0.126	0.191	0.509	0.566
miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	-0.126	0.191	0.509	0.566
mmr; MFS transporter, DHA2 family, methylenomycin A resistance protein	-0.121	0.201	0.548	0.566
mmuM, BHMT2; homocysteine S-methyltransferase [EC:2.1.1.10]	-0.133	0.217	0.541	0.566
mnmA, trmU; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]	-0.126	0.191	0.509	0.566
mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-]	-0.126	0.191	0.509	0.566
mntH; manganese transport protein	-0.335	1.544	0.829	0.829
mraW, rsmH; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]	-0.126	0.191	0.509	0.566
mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]	-0.126	0.191	0.509	0.566
mrcA; penicillin-binding protein 1A [EC:2.4.1.129 3.4.16.4]	-0.126	0.191	0.509	0.566
mreC; rod shape-determining protein MreC	-0.126	0.191	0.509	0.566
mreD; rod shape-determining protein MreD	-0.126	0.191	0.509	0.566
mscL; large conductance mechanosensitive channel	-0.126	0.191	0.509	0.566
mscS; small conductance mechanosensitive channel	-0.126	0.191	0.509	0.566
msmE; raffinose/stachyose/melibiose transport system substrate-binding protein	-0.133	0.217	0.541	0.566
msmF; raffinose/stachyose/melibiose transport system permease protein	-0.133	0.217	0.541	0.566
msmG; raffinose/stachyose/melibiose transport system permease protein	-0.133	0.217	0.541	0.566
msmX, msmK, malK, sugC, ggtA, msiK; multiple sugar transport system ATP-binding protein	-0.128	0.194	0.510	0.566
msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12]	-0.126	0.191	0.509	0.566
mtaD; 5-methylthioadenosine/S-adenosylhomocysteine deaminase [EC:3.5.4.31 3.5.4.28]	-0.126	0.191	0.509	0.566
MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9]	-0.126	0.191	0.509	0.566
MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]	-0.126	0.191	0.509	0.566
mtnN, mtn, pfs; adenosylhomocysteine nucleosidase [EC:3.2.2.9]	-0.126	0.191	0.509	0.566
mtsA; iron/zinc/manganese/copper transport system substrate-binding protein	-0.126	0.191	0.509	0.566
mtsB; iron/zinc/manganese/copper transport system ATP-binding protein	-0.126	0.191	0.509	0.566
mtsC; iron/zinc/manganese/copper transport system permease protein	-0.126	0.191	0.509	0.566
mtsT; energy-coupling factor transport system substrate-specific component	-0.126	0.191	0.509	0.566
murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	-0.126	0.191	0.509	0.566
murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	-0.126	0.191	0.509	0.566
murC; UDP-N-acetylmuramate–alanine ligase [EC:6.3.2.8]	-0.126	0.191	0.509	0.566
murD; UDP-N-acetylmuramoylalanine–D-glutamate ligase [EC:6.3.2.9]	-0.126	0.191	0.509	0.566
murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase [EC:6.3.2.13]	-0.126	0.191	0.509	0.566
murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7]	-0.126	0.191	0.509	0.566
murF; UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase [EC:6.3.2.10]	-0.126	0.191	0.509	0.566
murG; UDP-N-acetylglucosamine–N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]	-0.126	0.191	0.509	0.566
murI; glutamate racemase [EC:5.1.1.3]	-0.126	0.191	0.509	0.566
murM; serine/alanine adding enzyme [EC:2.3.2.10]	-0.126	0.191	0.509	0.566
murN; alanine adding enzyme [EC:2.3.2.-]	-0.126	0.191	0.509	0.566
mutL; DNA mismatch repair protein MutL	-0.126	0.191	0.509	0.566
mutM, fpg; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]	-0.126	0.191	0.509	0.566
mutS; DNA mismatch repair protein MutS	-0.126	0.191	0.509	0.566
mutS2; DNA mismatch repair protein MutS2	-0.126	0.191	0.509	0.566
mutT, NUDT15, MTH2; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]	-0.128	0.194	0.510	0.566
mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]	-0.126	0.191	0.509	0.566
mvaA; hydroxymethylglutaryl-CoA reductase [EC:1.1.1.88]	-0.126	0.191	0.509	0.566
MVD, mvaD; diphosphomevalonate decarboxylase [EC:4.1.1.33]	-0.126	0.191	0.509	0.566
nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]	-0.126	0.191	0.509	0.566
nadE; NAD+ synthase [EC:6.3.1.5]	-0.126	0.191	0.509	0.566
nagA, AMDHD2; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25]	-0.126	0.191	0.509	0.566
nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6]	-0.126	0.191	0.509	0.566
nanE; N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9]	-0.126	0.191	0.509	0.566
NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22]	-0.126	0.191	0.509	0.566
ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	-0.121	0.201	0.548	0.566
NEU1; sialidase-1 [EC:3.2.1.18]	-0.121	0.201	0.548	0.566
niaX; niacin transporter	-0.126	0.191	0.509	0.566
npdA; NAD-dependent deacetylase [EC:3.5.1.-]	-0.126	0.191	0.509	0.566
NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]	-0.133	0.217	0.540	0.566
nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4]	-0.126	0.191	0.509	0.566
nrdH; glutaredoxin-like protein NrdH	-0.126	0.191	0.509	0.566
nrdI; protein involved in ribonucleotide reduction	-0.128	0.194	0.510	0.566
nrdR; transcriptional repressor NrdR	-0.126	0.191	0.509	0.566
nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]	-0.126	0.191	0.509	0.566
nspC; carboxynorspermidine decarboxylase [EC:4.1.1.96]	-0.121	0.201	0.548	0.566
NTH; endonuclease III [EC:4.2.99.18]	-0.126	0.191	0.509	0.566
nudB, ntpA; dihydroneopterin triphosphate diphosphatase [EC:3.6.1.67]	-0.133	0.217	0.540	0.566
nudF; ADP-ribose pyrophosphatase [EC:3.6.1.13]	-0.128	0.194	0.510	0.566
nusA; N utilization substance protein A	-0.126	0.191	0.509	0.566
nusB; N utilization substance protein B	-0.126	0.191	0.509	0.566
nusG; transcriptional antiterminator NusG	-0.126	0.191	0.509	0.566
obgE, cgtA; GTPase [EC:3.6.5.-]	-0.126	0.191	0.509	0.566
ogt, MGMT; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]	-0.126	0.191	0.509	0.566
oppA, mppA; oligopeptide transport system substrate-binding protein	-0.123	0.193	0.526	0.566
oppB; oligopeptide transport system permease protein	-0.126	0.191	0.509	0.566
oppC; oligopeptide transport system permease protein	-0.126	0.191	0.509	0.566
oppD; oligopeptide transport system ATP-binding protein	-0.126	0.191	0.509	0.566
oppF; oligopeptide transport system ATP-binding protein	-0.126	0.191	0.509	0.566
opuA; osmoprotectant transport system ATP-binding protein	-0.126	0.191	0.509	0.566
opuBD; osmoprotectant transport system permease protein	-0.126	0.191	0.509	0.566
OTC, argF, argI; ornithine carbamoyltransferase [EC:2.1.3.3]	-0.133	0.217	0.540	0.566
paaI; acyl-CoA thioesterase [EC:3.1.2.-]	-0.126	0.191	0.509	0.566
pabBC; para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:2.6.1.85 4.1.3.38]	-0.126	0.191	0.509	0.566
padR; PadR family transcriptional regulator, regulatory protein PadR	-0.124	0.191	0.517	0.566
panE, apbA; 2-dehydropantoate 2-reductase [EC:1.1.1.169]	-0.335	1.544	0.829	0.829
parA, soj; chromosome partitioning protein	-0.335	1.544	0.829	0.829
parB, spo0J; chromosome partitioning protein, ParB family	-0.126	0.191	0.509	0.566
parC; topoisomerase IV subunit A [EC:5.99.1.-]	-0.126	0.191	0.509	0.566
parE; topoisomerase IV subunit B [EC:5.99.1.-]	-0.126	0.191	0.509	0.566
PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15]	-0.126	0.191	0.509	0.566
pat; phosphinothricin acetyltransferase [EC:2.3.1.183]	-0.133	0.217	0.540	0.566
patA, rscA, lmrC, satA; ATP-binding cassette, subfamily B, multidrug efflux pump	-0.126	0.191	0.509	0.566
patA; aminotransferase [EC:2.6.1.-]	-0.126	0.191	0.509	0.566
patB, malY; cystathione beta-lyase [EC:4.4.1.8]	-0.126	0.191	0.509	0.566
patB, rscB, lmrC, satB; ATP-binding cassette, subfamily B, multidrug efflux pump	-0.126	0.191	0.509	0.566
pbp1b; penicillin-binding protein 1B	-0.126	0.191	0.509	0.566
pbp2A; penicillin-binding protein 2A [EC:2.4.1.129 3.4.16.4]	-0.126	0.191	0.509	0.566
pbp2B, penA; penicillin-binding protein 2B	-0.126	0.191	0.509	0.566
pbp2X; penicillin-binding protein 2X	-0.126	0.191	0.509	0.566
pbuG; putative MFS transporter, AGZA family, xanthine/uracil permease	-0.126	0.191	0.509	0.566
pbuX; xanthine permease	-0.121	0.201	0.547	0.566
pcaC; 4-carboxymuconolactone decarboxylase [EC:4.1.1.44]	-0.335	1.544	0.829	0.829
pcp; pyroglutamyl-peptidase [EC:3.4.19.3]	-0.121	0.201	0.548	0.566
PDF, def; peptide deformylase [EC:3.5.1.88]	-0.126	0.191	0.509	0.566
PDHA, pdhA; pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]	-0.126	0.191	0.509	0.566
PDHB, pdhB; pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]	-0.126	0.191	0.509	0.566
pdp; pyrimidine-nucleoside phosphorylase [EC:2.4.2.2]	-0.126	0.191	0.509	0.566
pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3]	-0.129	0.198	0.514	0.566
pdxK, pdxY; pyridoxine kinase [EC:2.7.1.35]	-0.128	0.194	0.510	0.566
pdxS, pdx1; pyridoxal 5’-phosphate synthase pdxS subunit [EC:4.3.3.6]	-0.121	0.201	0.548	0.566
pdxT, pdx2; 5’-phosphate synthase pdxT subunit [EC:4.3.3.6]	-0.121	0.201	0.548	0.566
pepA; glutamyl aminopeptidase [EC:3.4.11.7]	-0.126	0.191	0.509	0.566
pepDA, pepDB; dipeptidase [EC:3.4.-.-]	-0.133	0.217	0.540	0.566
pepE; dipeptidase E [EC:3.4.13.21]	-0.133	0.217	0.540	0.566
pepF, pepB; oligoendopeptidase F [EC:3.4.24.-]	-0.126	0.191	0.509	0.566
pepN; aminopeptidase N [EC:3.4.11.2]	-0.126	0.191	0.509	0.566
pepO; putative endopeptidase [EC:3.4.24.-]	-0.126	0.191	0.509	0.566
pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]	-0.126	0.191	0.509	0.566
pepQ; Xaa-Pro dipeptidase [EC:3.4.13.9]	-0.126	0.191	0.509	0.566
pepT; tripeptide aminopeptidase [EC:3.4.11.4]	-0.126	0.191	0.509	0.566
pepX; X-Pro dipeptidyl-peptidase [EC:3.4.14.11]	-0.128	0.194	0.510	0.566
perR; Fur family transcriptional regulator, peroxide stress response regulator	-0.133	0.217	0.540	0.566
pezA; HTH-type transcriptional regulator / antitoxin PezA	-0.121	0.201	0.547	0.566
pezT; UDP-N-acetylglucosamine kinase [EC:2.7.1.176]	-0.121	0.201	0.547	0.566
pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]	-0.126	0.191	0.509	0.566
pflA, pflC, pflE; pyruvate formate lyase activating enzyme [EC:1.97.1.4]	-0.128	0.194	0.510	0.566
PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]	-0.126	0.191	0.509	0.566
PGD, gnd, gntZ; 6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]	-0.126	0.191	0.509	0.566
PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3]	-0.126	0.191	0.509	0.566
pgl; 6-phosphogluconolactonase [EC:3.1.1.31]	-0.126	0.191	0.509	0.566
pgm; phosphoglucomutase [EC:5.4.2.2]	-0.126	0.191	0.509	0.566
pgsA, PGS1; CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	-0.126	0.191	0.509	0.566
pheA2; prephenate dehydratase [EC:4.2.1.51]	-0.126	0.191	0.509	0.566
phnA; protein PhnA	-0.126	0.191	0.509	0.566
phnB; PhnB protein	-0.133	0.217	0.540	0.566
phoH, phoL; phosphate starvation-inducible protein PhoH and related proteins	-0.126	0.191	0.509	0.566
phoU; phosphate transport system protein	-0.126	0.191	0.509	0.566
PK, pyk; pyruvate kinase [EC:2.7.1.40]	-0.126	0.191	0.509	0.566
plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]	-0.126	0.191	0.509	0.566
plsX; glycerol-3-phosphate acyltransferase PlsX [EC:2.3.1.15]	-0.126	0.191	0.509	0.566
plsY; glycerol-3-phosphate acyltransferase PlsY [EC:2.3.1.15]	-0.126	0.191	0.509	0.566
pncB, NAPRT1; nicotinate phosphoribosyltransferase [EC:6.3.4.21]	-0.126	0.191	0.509	0.566
pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42]	-0.126	0.191	0.509	0.566
pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]	-0.126	0.191	0.509	0.566
pnuC; nicotinamide mononucleotide transporter	-0.126	0.191	0.509	0.566
polA; DNA polymerase I [EC:2.7.7.7]	-0.126	0.191	0.509	0.566
polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]	-0.126	0.191	0.509	0.566
potA; spermidine/putrescine transport system ATP-binding protein [EC:3.6.3.31]	-0.126	0.191	0.509	0.566
potB; spermidine/putrescine transport system permease protein	-0.126	0.191	0.509	0.566
potC; spermidine/putrescine transport system permease protein	-0.126	0.191	0.509	0.566
potD; spermidine/putrescine transport system substrate-binding protein	-0.126	0.191	0.509	0.566
ppaC; manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1]	-0.126	0.191	0.509	0.566
ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31]	-0.126	0.191	0.509	0.566
PPCDC, coaC; phosphopantothenoylcysteine decarboxylase [EC:4.1.1.36]	-0.126	0.191	0.509	0.566
PPCS, COAB; phosphopantothenate—cysteine ligase (ATP) [EC:6.3.2.51]	-0.126	0.191	0.509	0.566
ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1]	-0.133	0.217	0.540	0.566
pphA; serine/threonine protein phosphatase 1 [EC:3.1.3.16]	-0.126	0.191	0.509	0.566
PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8]	-0.126	0.191	0.509	0.566
PPIB, ppiB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]	-0.126	0.191	0.509	0.566
ppnK, NADK; NAD+ kinase [EC:2.7.1.23]	-0.126	0.191	0.509	0.566
pps, ppsA; pyruvate, water dikinase [EC:2.7.9.2]	-0.133	0.217	0.540	0.566
ppsR; [pyruvate, water dikinase]-phosphate phosphotransferase / [pyruvate, water dikinase] kinase [EC:2.7.4.28 2.7.11.33]	-0.133	0.217	0.541	0.566
praC, xylH; 4-oxalocrotonate tautomerase [EC:5.3.2.6]	-0.126	0.191	0.509	0.566
prdX, proX; Ala-tRNA(Pro) deacylase [EC:3.1.1.-]	-0.133	0.217	0.540	0.566
prfA, MTRF1, MRF1; peptide chain release factor 1	-0.126	0.191	0.509	0.566
prfB; peptide chain release factor 2	-0.126	0.191	0.509	0.566
prfC; peptide chain release factor 3	-0.126	0.191	0.509	0.566
priA; primosomal protein N’ (replication factor Y) (superfamily II helicase) [EC:3.6.4.-]	-0.126	0.191	0.509	0.566
prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]	-0.126	0.191	0.509	0.566
proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	-0.126	0.191	0.509	0.566
proB; glutamate 5-kinase [EC:2.7.2.11]	-0.126	0.191	0.509	0.566
proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]	-0.126	0.191	0.509	0.566
proV; glycine betaine/proline transport system ATP-binding protein [EC:3.6.3.32]	-0.335	1.544	0.829	0.829
proX; glycine betaine/proline transport system substrate-binding protein	-0.335	1.544	0.829	0.829
PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]	-0.126	0.191	0.509	0.566
prsA; foldase protein PrsA [EC:5.2.1.8]	-0.126	0.191	0.509	0.566
psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65]	-0.133	0.217	0.540	0.566
pstA; phosphate transport system permease protein	-0.126	0.191	0.509	0.566
pstB; phosphate transport system ATP-binding protein [EC:3.6.3.27]	-0.125	0.191	0.513	0.566
pstC; phosphate transport system permease protein	-0.126	0.191	0.509	0.566
pstS; phosphate transport system substrate-binding protein	-0.126	0.191	0.509	0.566
PTH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]	-0.126	0.191	0.509	0.566
PTS-Aga-EIIA, agaF; PTS system, N-acetylgalactosamine-specific IIA component [EC:2.7.1.-]	-0.126	0.191	0.509	0.566
PTS-Bgl-EIIC, bglF, bglP; PTS system, beta-glucoside-specific IIC component	-0.335	1.544	0.829	0.829
PTS-Cel-EIIA, celC, chbA; PTS system, cellobiose-specific IIA component [EC:2.7.1.196 2.7.1.205]	-0.133	0.217	0.541	0.566
PTS-Cel-EIIB, celA, chbB; PTS system, cellobiose-specific IIB component [EC:2.7.1.196 2.7.1.205]	-0.133	0.217	0.541	0.566
PTS-Cel-EIIC, celB, chbC; PTS system, cellobiose-specific IIC component	-0.133	0.217	0.541	0.566
PTS-EI.PTSI, ptsI; phosphotransferase system, enzyme I, PtsI [EC:2.7.3.9]	-0.126	0.191	0.509	0.566
PTS-Fru-EIIC, fruA; PTS system, fructose-specific IIC component	-0.126	0.191	0.509	0.566
PTS-Fru1-EIID, levG; PTS system, fructose-specific IID component	-0.126	0.191	0.509	0.566
PTS-Gat-EIIA, gatA, sgcA; PTS system, galactitol-specific IIA component [EC:2.7.1.200]	-0.121	0.201	0.547	0.566
PTS-Gat-EIIB, gatB, sgcB; PTS system, galactitol-specific IIB component [EC:2.7.1.200]	-0.121	0.201	0.547	0.566
PTS-Gat-EIIC, gatC, sgcC; PTS system, galactitol-specific IIC component	-0.121	0.201	0.547	0.566
PTS-Glc-EIIC, ptsG; PTS system, glucose-specific IIC component	-0.126	0.191	0.509	0.566
PTS-Gut-EIIA, srlB; PTS system, glucitol/sorbitol-specific IIA component [EC:2.7.1.198]	-0.335	1.544	0.829	0.829
PTS-Gut-EIIC, srlA; PTS system, glucitol/sorbitol-specific IIC component	-0.335	1.544	0.829	0.829
PTS-HPR; phosphocarrier protein	-0.126	0.191	0.509	0.566
PTS-Lac-EIIA, lacF; PTS system, lactose-specific IIA component [EC:2.7.1.207]	-0.126	0.191	0.509	0.566
PTS-Lac-EIIC, lacE; PTS system, lactose-specific IIC component	-0.126	0.191	0.509	0.566
PTS-Man-EIIA, manX; PTS system, mannose-specific IIA component [EC:2.7.1.191]	-0.126	0.191	0.509	0.566
PTS-Man-EIIB, manX; PTS system, mannose-specific IIB component [EC:2.7.1.191]	-0.126	0.191	0.509	0.566
PTS-Man-EIIC, manY; PTS system, mannose-specific IIC component	-0.126	0.191	0.509	0.566
PTS-Man-EIID, manZ; PTS system, mannose-specific IID component	-0.126	0.191	0.509	0.566
PTS-Scr-EIIC, scrA, sacP, sacX, ptsS; PTS system, sucrose-specific IIC component	-0.126	0.191	0.509	0.566
PTS-Tre-EIIC, treB; PTS system, trehalose-specific IIC component	-0.133	0.217	0.540	0.566
PTS-Ula-EIIA, ulaC, sgaA; PTS system, ascorbate-specific IIA component [EC:2.7.1.194]	-0.133	0.217	0.541	0.566
PTS-Ula-EIIB, ulaB, sgaB; PTS system, ascorbate-specific IIB component [EC:2.7.1.194]	-0.126	0.191	0.510	0.566
PTS-Ula-EIIC, ulaA, sgaT; PTS system, ascorbate-specific IIC component	-0.126	0.191	0.510	0.566
pulA; pullulanase [EC:3.2.1.41]	-0.129	0.198	0.514	0.566
punA, PNP; purine-nucleoside phosphorylase [EC:2.4.2.1]	-0.126	0.191	0.509	0.566
purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4]	-0.126	0.191	0.509	0.566
purB, ADSL; adenylosuccinate lyase [EC:4.3.2.2]	-0.126	0.191	0.509	0.566
purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]	-0.126	0.191	0.509	0.566
purD; phosphoribosylamine—glycine ligase [EC:6.3.4.13]	-0.126	0.191	0.509	0.566
purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]	-0.126	0.191	0.509	0.566
purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	-0.126	0.191	0.509	0.566
purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]	-0.126	0.191	0.509	0.566
purK; 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18]	-0.126	0.191	0.509	0.566
purL, PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]	-0.126	0.191	0.509	0.566
purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]	-0.126	0.191	0.509	0.566
purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]	-0.126	0.191	0.509	0.566
purR; purine operon repressor	-0.126	0.191	0.509	0.566
PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	-0.128	0.194	0.510	0.566
pyrB, PYR2; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]	-0.126	0.191	0.509	0.566
pyrD; dihydroorotate dehydrogenase (fumarate) [EC:1.3.98.1]	-0.126	0.191	0.509	0.566
pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14]	-0.126	0.191	0.509	0.566
pyrDII; dihydroorotate dehydrogenase electron transfer subunit	-0.126	0.191	0.509	0.566
pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10]	-0.126	0.191	0.509	0.566
pyrF; orotidine-5’-phosphate decarboxylase [EC:4.1.1.23]	-0.126	0.191	0.509	0.566
pyrG, CTPS; CTP synthase [EC:6.3.4.2]	-0.126	0.191	0.509	0.566
pyrH; uridylate kinase [EC:2.7.4.22]	-0.126	0.191	0.509	0.566
pyrP, uraA; uracil permease	-0.126	0.191	0.509	0.566
pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9]	-0.126	0.191	0.509	0.566
qrtT; energy-coupling factor transport system substrate-specific component	-0.335	1.544	0.829	0.829
queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]	-0.126	0.191	0.509	0.566
queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	-0.121	0.201	0.548	0.566
queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]	-0.121	0.201	0.548	0.566
queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]	-0.121	0.201	0.548	0.566
queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]	-0.121	0.201	0.548	0.566
queG; epoxyqueuosine reductase [EC:1.17.99.6]	-0.133	0.217	0.541	0.566
queH; epoxyqueuosine reductase [EC:1.17.99.6]	-0.121	0.201	0.547	0.566
racD; aspartate racemase [EC:5.1.1.13]	-0.335	1.544	0.829	0.829
radA, sms; DNA repair protein RadA/Sms	-0.126	0.191	0.509	0.566
radC; DNA repair protein RadC	-0.126	0.191	0.509	0.566
rapZ; RNase adapter protein RapZ	-0.126	0.191	0.509	0.566
RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19]	-0.126	0.191	0.509	0.566
rbfA; ribosome-binding factor A	-0.126	0.191	0.509	0.566
rbgA; ribosome biogenesis GTPase A	-0.126	0.191	0.509	0.566
rbsB; ribose transport system substrate-binding protein	-0.126	0.191	0.509	0.566
rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66]	-0.126	0.191	0.509	0.566
recA; recombination protein RecA	-0.126	0.191	0.509	0.566
recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]	-0.126	0.191	0.509	0.566
recF; DNA replication and repair protein RecF	-0.126	0.191	0.509	0.566
recG; ATP-dependent DNA helicase RecG [EC:3.6.4.12]	-0.126	0.191	0.509	0.566
recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]	-0.126	0.191	0.509	0.566
recN; DNA repair protein RecN (Recombination protein N)	-0.126	0.191	0.509	0.566
recO; DNA repair protein RecO (recombination protein O)	-0.126	0.191	0.509	0.566
recR; recombination protein RecR	-0.126	0.191	0.509	0.566
recU; recombination protein U	-0.126	0.191	0.509	0.566
recX; regulatory protein	-0.126	0.191	0.509	0.566
relA; GTP pyrophosphokinase [EC:2.7.6.5]	-0.126	0.191	0.509	0.566
relE, stbE; mRNA interferase RelE/StbE	-0.121	0.201	0.547	0.566
rex; redox-sensing transcriptional repressor	-0.126	0.191	0.509	0.566
rfbC, rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]	-0.133	0.217	0.540	0.566
rfbD, rmlD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]	-0.133	0.217	0.540	0.566
rgpA; rhamnosyltransferase [EC:2.4.1.-]	-0.133	0.217	0.539	0.566
rgpB; rhamnosyltransferase [EC:2.4.1.-]	-0.133	0.217	0.540	0.566
rgpE; glucosyltransferase [EC:2.4.1.-]	-0.335	1.544	0.829	0.829
rgpF; rhamnosyltransferase [EC:2.4.1.-]	-0.133	0.217	0.540	0.566
ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]	-0.126	0.191	0.509	0.566
ridA, tdcF, RIDA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10]	-0.126	0.191	0.509	0.566
rimI; [ribosomal protein S18]-alanine N-acetyltransferase [EC:2.3.1.266]	-0.128	0.194	0.510	0.566
rimJ; [ribosomal protein S5]-alanine N-acetyltransferase [EC:2.3.1.267]	-0.128	0.194	0.510	0.566
rimM; 16S rRNA processing protein RimM	-0.126	0.191	0.509	0.566
rimP; ribosome maturation factor RimP	-0.126	0.191	0.509	0.566
rlmA1; 23S rRNA (guanine745-N1)-methyltransferase [EC:2.1.1.187]	-0.126	0.191	0.509	0.566
rlmB; 23S rRNA (guanosine2251-2’-O)-methyltransferase [EC:2.1.1.185]	-0.126	0.191	0.509	0.566
rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177]	-0.126	0.191	0.509	0.566
rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191]	-0.126	0.191	0.509	0.566
rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]	-0.126	0.191	0.509	0.566
rluA; tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29]	-0.133	0.217	0.540	0.566
rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]	-0.126	0.191	0.509	0.566
rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]	-0.126	0.191	0.509	0.566
rmuC; DNA recombination protein RmuC	-0.126	0.191	0.509	0.566
rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3]	-0.126	0.191	0.509	0.566
rnhB; ribonuclease HII [EC:3.1.26.4]	-0.124	0.191	0.517	0.566
rnhC; ribonuclease HIII [EC:3.1.26.4]	-0.126	0.191	0.509	0.566
rnj; ribonuclease J [EC:3.1.-.-]	-0.126	0.191	0.509	0.566
rnmV; ribonuclease M5 [EC:3.1.26.8]	-0.126	0.191	0.509	0.566
rnpA; ribonuclease P protein component [EC:3.1.26.5]	-0.126	0.191	0.509	0.566
rnr, vacB; ribonuclease R [EC:3.1.-.-]	-0.126	0.191	0.509	0.566
rny; ribonucrease Y [EC:3.1.-.-]	-0.126	0.191	0.509	0.566
rnz; ribonuclease Z [EC:3.1.26.11]	-0.126	0.191	0.509	0.566
rodA, mrdB; rod shape determining protein RodA	-0.126	0.191	0.509	0.566
RP-L1, MRPL1, rplA; large subunit ribosomal protein L1	-0.126	0.191	0.509	0.566
RP-L10, MRPL10, rplJ; large subunit ribosomal protein L10	-0.126	0.191	0.509	0.566
RP-L11, MRPL11, rplK; large subunit ribosomal protein L11	-0.126	0.191	0.509	0.566
RP-L13, MRPL13, rplM; large subunit ribosomal protein L13	-0.126	0.191	0.509	0.566
RP-L14, MRPL14, rplN; large subunit ribosomal protein L14	-0.126	0.191	0.509	0.566
RP-L15, MRPL15, rplO; large subunit ribosomal protein L15	-0.126	0.191	0.509	0.566
RP-L16, MRPL16, rplP; large subunit ribosomal protein L16	-0.126	0.191	0.509	0.566
RP-L17, MRPL17, rplQ; large subunit ribosomal protein L17	-0.126	0.191	0.509	0.566
RP-L18, MRPL18, rplR; large subunit ribosomal protein L18	-0.126	0.191	0.509	0.566
RP-L19, MRPL19, rplS; large subunit ribosomal protein L19	-0.126	0.191	0.509	0.566
RP-L2, MRPL2, rplB; large subunit ribosomal protein L2	-0.126	0.191	0.509	0.566
RP-L20, MRPL20, rplT; large subunit ribosomal protein L20	-0.126	0.191	0.509	0.566
RP-L21, MRPL21, rplU; large subunit ribosomal protein L21	-0.126	0.191	0.509	0.566
RP-L22, MRPL22, rplV; large subunit ribosomal protein L22	-0.126	0.191	0.509	0.566
RP-L23, MRPL23, rplW; large subunit ribosomal protein L23	-0.126	0.191	0.509	0.566
RP-L24, MRPL24, rplX; large subunit ribosomal protein L24	-0.126	0.191	0.509	0.566
RP-L27, MRPL27, rpmA; large subunit ribosomal protein L27	-0.126	0.191	0.509	0.566
RP-L28, MRPL28, rpmB; large subunit ribosomal protein L28	-0.126	0.191	0.509	0.566
RP-L29, rpmC; large subunit ribosomal protein L29	-0.126	0.191	0.509	0.566
RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	-0.126	0.191	0.509	0.566
RP-L30, MRPL30, rpmD; large subunit ribosomal protein L30	-0.126	0.191	0.509	0.566
RP-L31, rpmE; large subunit ribosomal protein L31	-0.126	0.191	0.509	0.566
RP-L32, MRPL32, rpmF; large subunit ribosomal protein L32	-0.126	0.191	0.509	0.566
RP-L33, MRPL33, rpmG; large subunit ribosomal protein L33	-0.128	0.194	0.510	0.566
RP-L34, MRPL34, rpmH; large subunit ribosomal protein L34	-0.126	0.191	0.509	0.566
RP-L35, MRPL35, rpmI; large subunit ribosomal protein L35	-0.126	0.191	0.509	0.566
RP-L36, MRPL36, rpmJ; large subunit ribosomal protein L36	-0.133	0.217	0.540	0.566
RP-L4, MRPL4, rplD; large subunit ribosomal protein L4	-0.126	0.191	0.509	0.566
RP-L5, MRPL5, rplE; large subunit ribosomal protein L5	-0.126	0.191	0.509	0.566
RP-L6, MRPL6, rplF; large subunit ribosomal protein L6	-0.126	0.191	0.509	0.566
RP-L7, MRPL12, rplL; large subunit ribosomal protein L7/L12	-0.126	0.191	0.509	0.566
RP-L9, MRPL9, rplI; large subunit ribosomal protein L9	-0.126	0.191	0.509	0.566
RP-S1, rpsA; small subunit ribosomal protein S1	-0.126	0.191	0.509	0.566
RP-S10, MRPS10, rpsJ; small subunit ribosomal protein S10	-0.126	0.191	0.509	0.566
RP-S11, MRPS11, rpsK; small subunit ribosomal protein S11	-0.126	0.191	0.509	0.566
RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12	-0.126	0.191	0.509	0.566
RP-S13, rpsM; small subunit ribosomal protein S13	-0.126	0.191	0.509	0.566
RP-S14, MRPS14, rpsN; small subunit ribosomal protein S14	-0.126	0.191	0.509	0.566
RP-S15, MRPS15, rpsO; small subunit ribosomal protein S15	-0.126	0.191	0.509	0.566
RP-S16, MRPS16, rpsP; small subunit ribosomal protein S16	-0.126	0.191	0.509	0.566
RP-S17, MRPS17, rpsQ; small subunit ribosomal protein S17	-0.126	0.191	0.509	0.566
RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18	-0.126	0.191	0.509	0.566
RP-S19, rpsS; small subunit ribosomal protein S19	-0.126	0.191	0.509	0.566
RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2	-0.126	0.191	0.509	0.566
RP-S20, rpsT; small subunit ribosomal protein S20	-0.126	0.191	0.509	0.566
RP-S21, MRPS21, rpsU; small subunit ribosomal protein S21	-0.126	0.191	0.509	0.566
RP-S3, rpsC; small subunit ribosomal protein S3	-0.126	0.191	0.509	0.566
RP-S4, rpsD; small subunit ribosomal protein S4	-0.126	0.191	0.509	0.566
RP-S5, MRPS5, rpsE; small subunit ribosomal protein S5	-0.126	0.191	0.509	0.566
RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6	-0.126	0.191	0.509	0.566
RP-S7, MRPS7, rpsG; small subunit ribosomal protein S7	-0.126	0.191	0.509	0.566
RP-S8, rpsH; small subunit ribosomal protein S8	-0.126	0.191	0.509	0.566
RP-S9, MRPS9, rpsI; small subunit ribosomal protein S9	-0.126	0.191	0.509	0.566
rpe, RPE; ribulose-phosphate 3-epimerase [EC:5.1.3.1]	-0.126	0.191	0.509	0.566
rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	-0.126	0.191	0.509	0.566
rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]	-0.126	0.191	0.509	0.566
rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]	-0.126	0.191	0.509	0.566
rpoC; DNA-directed RNA polymerase subunit beta’ [EC:2.7.7.6]	-0.126	0.191	0.509	0.566
rpoD; RNA polymerase primary sigma factor	-0.126	0.191	0.509	0.566
rpoE; DNA-directed RNA polymerase subunit delta	-0.126	0.191	0.509	0.566
rpoE; RNA polymerase sigma-70 factor, ECF subfamily	-0.133	0.217	0.541	0.566
rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]	-0.126	0.191	0.509	0.566
rseP; regulator of sigma E protease [EC:3.4.24.-]	-0.126	0.191	0.509	0.566
rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]	-0.126	0.191	0.509	0.566
rsmB, sun; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]	-0.126	0.191	0.509	0.566
rsmC; 16S rRNA (guanine1207-N2)-methyltransferase [EC:2.1.1.172]	-0.126	0.191	0.509	0.566
rsmD; 16S rRNA (guanine966-N2)-methyltransferase [EC:2.1.1.171]	-0.126	0.191	0.509	0.566
rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]	-0.126	0.191	0.509	0.566
rsmI; 16S rRNA (cytidine1402-2’-O)-methyltransferase [EC:2.1.1.198]	-0.126	0.191	0.509	0.566
rstA1; phage replication initiation protein	-0.335	1.544	0.829	0.829
rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]	-0.126	0.191	0.509	0.566
rtpR; ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2]	-0.126	0.191	0.509	0.566
rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190]	-0.126	0.191	0.509	0.566
ruvA; holliday junction DNA helicase RuvA [EC:3.6.4.12]	-0.126	0.191	0.509	0.566
ruvB; holliday junction DNA helicase RuvB [EC:3.6.4.12]	-0.126	0.191	0.509	0.566
ruvX; putative holliday junction resolvase [EC:3.1.-.-]	-0.126	0.191	0.509	0.566
saeR; two-component system, OmpR family, response regulator SaeR	-0.126	0.191	0.509	0.566
saeS; two-component system, OmpR family, sensor histidine kinase SaeS [EC:2.7.13.3]	-0.126	0.191	0.509	0.566
SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11]	-0.126	0.191	0.509	0.566
sbcC, rad50; DNA repair protein SbcC/Rad50	-0.335	1.544	0.829	0.829
scpA; segregation and condensation protein A	-0.126	0.191	0.509	0.566
scpB; segregation and condensation protein B	-0.126	0.191	0.509	0.566
scrR; LacI family transcriptional regulator, sucrose operon repressor	-0.126	0.191	0.509	0.566
secA; preprotein translocase subunit SecA	-0.126	0.191	0.509	0.566
secE; preprotein translocase subunit SecE	-0.133	0.217	0.540	0.566
secG; preprotein translocase subunit SecG	-0.126	0.191	0.509	0.566
secY; preprotein translocase subunit SecY	-0.126	0.191	0.509	0.566
sepF; cell division inhibitor SepF	-0.126	0.191	0.509	0.566
serA, PHGDH; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]	-0.133	0.217	0.541	0.566
serB, PSPH; phosphoserine phosphatase [EC:3.1.3.3]	-0.126	0.191	0.509	0.566
serC, PSAT1; phosphoserine aminotransferase [EC:2.6.1.52]	-0.133	0.217	0.541	0.566
slo; thiol-activated cytolysin	-0.121	0.201	0.548	0.566
smc; chromosome segregation protein	-0.126	0.191	0.509	0.566
smf; DNA processing protein	-0.126	0.191	0.509	0.566
smpB; SsrA-binding protein	-0.126	0.191	0.509	0.566
SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	-0.126	0.191	0.509	0.566
speE, SRM; spermidine synthase [EC:2.5.1.16]	-0.121	0.201	0.548	0.566
speG, SAT; diamine N-acetyltransferase [EC:2.3.1.57]	-0.121	0.201	0.547	0.566
spoU; RNA methyltransferase, TrmH family	-0.126	0.191	0.509	0.566
SPP; sucrose-6-phosphatase [EC:3.1.3.24]	-0.127	0.191	0.509	0.566
sprL; SprT-like protein	-0.133	0.217	0.540	0.566
spxA; regulatory protein spx	-0.126	0.191	0.510	0.566
srlD; sorbitol-6-phosphate 2-dehydrogenase [EC:1.1.1.140]	-0.335	1.544	0.829	0.829
SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4]	-0.126	0.191	0.509	0.566
srtA; sortase A [EC:3.4.22.70]	-0.128	0.194	0.510	0.566
srtB; sortase B [EC:3.4.22.70]	-0.133	0.217	0.540	0.566
ssb; single-strand DNA-binding protein	-0.126	0.191	0.509	0.566
sstT; serine/threonine transporter	-0.126	0.191	0.509	0.566
sufB; Fe-S cluster assembly protein SufB	-0.128	0.194	0.510	0.566
sufC; Fe-S cluster assembly ATP-binding protein	-0.126	0.191	0.509	0.566
sufD; Fe-S cluster assembly protein SufD	-0.126	0.191	0.509	0.566
sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16]	-0.126	0.191	0.509	0.566
sulD; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:4.1.2.25 2.7.6.3]	-0.126	0.191	0.509	0.566
tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]	-0.126	0.191	0.509	0.566
tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]	-0.126	0.191	0.509	0.566
tagE; poly(glycerol-phosphate) alpha-glucosyltransferase [EC:2.4.1.52]	-0.133	0.217	0.540	0.566
tarJ; ribitol-5-phosphate 2-dehydrogenase (NADP+) [EC:1.1.1.405]	-0.121	0.201	0.548	0.566
TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3]	-0.126	0.191	0.509	0.566
tatA; sec-independent protein translocase protein TatA	-0.133	0.217	0.540	0.566
tatC; sec-independent protein translocase protein TatC	-0.133	0.217	0.540	0.566
tatD; TatD DNase family protein [EC:3.1.21.-]	-0.126	0.191	0.509	0.566
TC.AAT; amino acid transporter, AAT family	-0.121	0.201	0.548	0.566
TC.AGCS; alanine or glycine:cation symporter, AGCS family	-0.126	0.191	0.510	0.566
TC.APA; basic amino acid/polyamine antiporter, APA family	-0.126	0.191	0.509	0.566
TC.CPA1; monovalent cation:H+ antiporter, CPA1 family	-0.121	0.201	0.548	0.566
TC.DAACS; dicarboxylate/amino acid:cation (Na+ or H+) symporter, DAACS family	-0.133	0.217	0.540	0.566
TC.LIVCS; branched-chain amino acid:cation transporter, LIVCS family	-0.126	0.191	0.509	0.566
TC.MATE, SLC47A, norM, mdtK, dinF; multidrug resistance protein, MATE family	-0.126	0.191	0.509	0.566
TC.NSS; neurotransmitter:Na+ symporter, NSS family	-0.121	0.201	0.548	0.566
TC.POT; proton-dependent oligopeptide transporter, POT family	-0.121	0.201	0.548	0.566
TC.SSS; solute:Na+ symporter, SSS family	-0.335	1.544	0.829	0.829
TC.ZIP, zupT, ZRT3, ZIP2; zinc transporter, ZIP family	-0.133	0.217	0.540	0.566
tcyK; L-cystine transport system substrate-binding protein	-0.126	0.191	0.510	0.566
tcyL; L-cystine transport system permease protein	-0.126	0.191	0.510	0.566
tcyM; L-cystine transport system permease protein	-0.124	0.191	0.517	0.566
tcyN; L-cystine transport system ATP-binding protein [EC:3.6.3.-]	-0.126	0.191	0.510	0.566
tdk, TK; thymidine kinase [EC:2.7.1.21]	-0.126	0.191	0.509	0.566
tehB; tellurite methyltransferase [EC:2.1.1.265]	-0.126	0.191	0.509	0.566
tenA; thiaminase (transcriptional activator TenA) [EC:3.5.99.2]	-0.121	0.201	0.548	0.566
tex; protein Tex	-0.126	0.191	0.509	0.566
tgt, QTRT1; queuine tRNA-ribosyltransferase [EC:2.4.2.29]	-0.126	0.191	0.509	0.566
thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7]	-0.121	0.201	0.548	0.566
thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]	-0.121	0.201	0.548	0.566
thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4]	-0.126	0.191	0.509	0.566
thiJ; protein deglycase [EC:3.5.1.124]	-0.128	0.194	0.510	0.566
thiM; hydroxyethylthiazole kinase [EC:2.7.1.50]	-0.121	0.201	0.548	0.566
thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2]	-0.126	0.191	0.509	0.566
thrB1; homoserine kinase [EC:2.7.1.39]	-0.126	0.191	0.509	0.566
thrC; threonine synthase [EC:4.2.3.1]	-0.126	0.191	0.509	0.566
thyA, TYMS; thymidylate synthase [EC:2.1.1.45]	-0.126	0.191	0.509	0.566
tig; trigger factor	-0.126	0.191	0.509	0.566
tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]	-0.126	0.191	0.509	0.566
tlyA; 23S rRNA (cytidine1920-2’-O)/16S rRNA (cytidine1409-2’-O)-methyltransferase [EC:2.1.1.226 2.1.1.227]	-0.126	0.191	0.509	0.566
tlyC; putative hemolysin	-0.126	0.191	0.509	0.566
tmk, DTYMK; dTMP kinase [EC:2.7.4.9]	-0.126	0.191	0.509	0.566
topA; DNA topoisomerase I [EC:5.99.1.2]	-0.126	0.191	0.509	0.566
topB; DNA topoisomerase III [EC:5.99.1.2]	-0.335	1.544	0.829	0.829
TPI, tpiA; triosephosphate isomerase (TIM) [EC:5.3.1.1]	-0.126	0.191	0.509	0.566
tpx; thiol peroxidase, atypical 2-Cys peroxiredoxin [EC:1.11.1.15]	-0.126	0.191	0.509	0.566
treC; trehalose-6-phosphate hydrolase [EC:3.2.1.93]	-0.133	0.217	0.540	0.566
treR2, treR; GntR family transcriptional regulator, trehalose operon transcriptional repressor	-0.133	0.217	0.540	0.566
trkA, ktrA; trk system potassium uptake protein	-0.126	0.191	0.509	0.566
trkH, trkG, ktrB; trk system potassium uptake protein	-0.126	0.191	0.509	0.566
trmB, METTL1; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]	-0.126	0.191	0.509	0.566
trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]	-0.126	0.191	0.509	0.566
trmFO, gid; methylenetetrahydrofolate–tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]	-0.126	0.191	0.509	0.566
trmK; tRNA (adenine22-N1)-methyltransferase [EC:2.1.1.217]	-0.126	0.191	0.509	0.566
trmL, cspR; tRNA (cytidine/uridine-2’-O-)-methyltransferase [EC:2.1.1.207]	-0.126	0.191	0.509	0.566
troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator	-0.126	0.191	0.509	0.566
trpA; tryptophan synthase alpha chain [EC:4.2.1.20]	-0.126	0.191	0.509	0.566
trpB; tryptophan synthase beta chain [EC:4.2.1.20]	-0.126	0.191	0.509	0.566
trpC; indole-3-glycerol phosphate synthase [EC:4.1.1.48]	-0.126	0.191	0.509	0.566
trpD; anthranilate phosphoribosyltransferase [EC:2.4.2.18]	-0.126	0.191	0.509	0.566
trpE; anthranilate synthase component I [EC:4.1.3.27]	-0.126	0.191	0.509	0.566
trpF; phosphoribosylanthranilate isomerase [EC:5.3.1.24]	-0.126	0.191	0.509	0.566
trpG; anthranilate synthase component II [EC:4.1.3.27]	-0.126	0.191	0.509	0.566
truA, PUS1; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]	-0.126	0.191	0.509	0.566
truB, PUS4, TRUB1; tRNA pseudouridine55 synthase [EC:5.4.99.25]	-0.126	0.191	0.509	0.566
trxA; thioredoxin 1	-0.128	0.194	0.510	0.566
trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9]	-0.126	0.191	0.509	0.566
tsaC, rimN, SUA5; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]	-0.126	0.191	0.509	0.566
tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE	-0.126	0.191	0.509	0.566
tsf, TSFM; elongation factor Ts	-0.126	0.191	0.509	0.566
tuf, TUFM; elongation factor Tu	-0.126	0.191	0.509	0.566
typA, bipA; GTP-binding protein	-0.126	0.191	0.509	0.566
tyrA1; chorismate mutase [EC:5.4.99.5]	-0.335	1.544	0.829	0.829
tyrA2; prephenate dehydrogenase [EC:1.3.1.12]	-0.126	0.191	0.509	0.566
ubiA; 4-hydroxybenzoate polyprenyltransferase [EC:2.5.1.39]	-0.133	0.217	0.540	0.566
udk, UCK; uridine kinase [EC:2.7.1.48]	-0.126	0.191	0.509	0.566
UGP2, galU, galF; UTP–glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]	-0.126	0.191	0.509	0.566
ulaG; L-ascorbate 6-phosphate lactonase [EC:3.1.1.-]	-0.133	0.217	0.541	0.566
umuC; DNA polymerase V	-0.126	0.191	0.509	0.566
UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27]	-0.126	0.191	0.509	0.566
upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9]	-0.126	0.191	0.509	0.566
uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]	-0.126	0.191	0.509	0.566
URA4, pyrC; dihydroorotase [EC:3.5.2.3]	-0.126	0.191	0.509	0.566
uup; ABC transport system ATP-binding/permease protein	-0.126	0.191	0.509	0.566
uvrA; excinuclease ABC subunit A	-0.126	0.191	0.509	0.566
uvrB; excinuclease ABC subunit B	-0.126	0.191	0.509	0.566
uvrC; excinuclease ABC subunit C	-0.126	0.191	0.509	0.566
uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12]	-0.126	0.191	0.509	0.566
vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14]	-0.128	0.194	0.510	0.566
VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9]	-0.126	0.191	0.509	0.566
vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]	-0.126	0.191	0.509	0.566
vicR; two-component system, OmpR family, response regulator VicR	-0.126	0.191	0.509	0.566
virD4, lvhD4; type IV secretion system protein VirD4	-0.335	1.544	0.829	0.829
WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]	-0.126	0.191	0.509	0.566
wecA, tagO, rfe; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]	-0.133	0.217	0.540	0.566
xerD; integrase/recombinase XerD	-0.121	0.201	0.548	0.566
xfp, xpk; xylulose-5-phosphate/fructose-6-phosphate phosphoketolase [EC:4.1.2.9 4.1.2.22]	-0.335	1.544	0.829	0.829
xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22]	-0.126	0.191	0.509	0.566
xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]	-0.126	0.191	0.509	0.566
xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]	-0.126	0.191	0.509	0.566
yaeR; glyoxylase I family protein	-0.133	0.217	0.540	0.566
yafQ; mRNA interferase YafQ [EC:3.1.-.-]	-0.126	0.191	0.509	0.566
yajC; preprotein translocase subunit YajC	-0.126	0.191	0.509	0.566
YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1]	-0.126	0.191	0.509	0.566
ybaK, ebsC; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]	-0.126	0.191	0.509	0.566
ybaZ; methylated-DNA-protein-cysteine methyltransferase related protein	-0.133	0.217	0.540	0.566
ybeB; ribosome-associated protein	-0.126	0.191	0.509	0.566
ybeY, yqfG; probable rRNA maturation factor	-0.126	0.191	0.509	0.566
ycaJ; putative ATPase	-0.126	0.191	0.509	0.566
ycgQ; putative membrane protein	-0.126	0.191	0.509	0.566
ychF; ribosome-binding ATPase	-0.126	0.191	0.509	0.566
yefM; antitoxin YefM	-0.121	0.201	0.548	0.566
yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]	-0.123	0.193	0.523	0.566
yesN; two-component system, response regulator YesN	-0.124	0.191	0.517	0.566
ygaC; uncharacterized protein	-0.126	0.191	0.509	0.566
yggS, PROSC; PLP dependent protein	-0.126	0.191	0.509	0.566
yggT; YggT family protein	-0.126	0.191	0.509	0.566
yghU, yfcG; GSH-dependent disulfide-bond oxidoreductase [EC:1.8.4.-]	-0.133	0.217	0.540	0.566
yhbH; putative sigma-54 modulation protein	-0.126	0.191	0.509	0.566
yhbY; RNA-binding protein	-0.126	0.191	0.509	0.566
yhgE; putative membrane protein	-0.126	0.191	0.509	0.566
yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase	-0.126	0.191	0.509	0.566
yjbB; phosphate:Na+ symporter	-0.126	0.191	0.509	0.566
yjgM; putative acetyltransferase [EC:2.3.1.-]	-0.133	0.217	0.540	0.566
ykoE; energy-coupling factor transport system substrate-specific component	-0.121	0.201	0.548	0.566
ylxR; uncharacterized protein	-0.126	0.191	0.509	0.566
ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-]	-0.126	0.191	0.509	0.566
yqeH; 30S ribosome assembly GTPase	-0.126	0.191	0.509	0.566
ysxB; uncharacterized protein	-0.126	0.191	0.509	0.566
ytmI; uncharacterized N-acetyltransferase [EC:2.3.1.-]	-0.121	0.201	0.548	0.566
zmpB; zinc metalloprotease ZmpB [EC:3.4.24.-]	-0.124	0.191	0.517	0.566
znuA; zinc transport system substrate-binding protein	-0.126	0.191	0.509	0.566
znuB; zinc transport system permease protein	-0.126	0.191	0.509	0.566
znuC; zinc transport system ATP-binding protein [EC:3.6.3.-]	-0.126	0.191	0.509	0.566

# merge with tb.ra for full results table
full.res <- left_join(tb.ra, results.out, by = "description")

write.csv(full.res, "output/picrust_ko_stratefied_strepto_data_results.csv", row.names = F)

Session information

sessionInfo()

R version 4.0.5 (2021-03-31)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19042)

Matrix products: default

locale:
[1] LC_COLLATE=English_United States.1252 
[2] LC_CTYPE=English_United States.1252   
[3] LC_MONETARY=English_United States.1252
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.1252    

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] cowplot_1.1.1     dendextend_1.14.0 ggdendro_0.1.22   reshape2_1.4.4   
 [5] car_3.0-10        carData_3.0-4     gvlma_1.0.0.3     patchwork_1.1.1  
 [9] viridis_0.5.1     viridisLite_0.3.0 gridExtra_2.3     xtable_1.8-4     
[13] kableExtra_1.3.4  MASS_7.3-53.1     data.table_1.14.0 readxl_1.3.1     
[17] forcats_0.5.1     stringr_1.4.0     dplyr_1.0.5       purrr_0.3.4      
[21] readr_1.4.0       tidyr_1.1.3       tibble_3.1.0      ggplot2_3.3.3    
[25] tidyverse_1.3.0   lmerTest_3.1-3    lme4_1.1-26       Matrix_1.3-2     
[29] vegan_2.5-7       lattice_0.20-41   permute_0.9-5     phyloseq_1.34.0  
[33] workflowr_1.6.2  

loaded via a namespace (and not attached):
  [1] minqa_1.2.4         colorspace_2.0-0    rio_0.5.26         
  [4] ellipsis_0.3.1      rprojroot_2.0.2     XVector_0.30.0     
  [7] fs_1.5.0            rstudioapi_0.13     farver_2.1.0       
 [10] fansi_0.4.2         lubridate_1.7.10    xml2_1.3.2         
 [13] codetools_0.2-18    splines_4.0.5       knitr_1.31         
 [16] ade4_1.7-16         jsonlite_1.7.2      nloptr_1.2.2.2     
 [19] broom_0.7.5         cluster_2.1.1       dbplyr_2.1.0       
 [22] BiocManager_1.30.10 compiler_4.0.5      httr_1.4.2         
 [25] backports_1.2.1     assertthat_0.2.1    cli_2.3.1          
 [28] later_1.1.0.1       htmltools_0.5.1.1   prettyunits_1.1.1  
 [31] tools_4.0.5         igraph_1.2.6        gtable_0.3.0       
 [34] glue_1.4.2          Rcpp_1.0.6          Biobase_2.50.0     
 [37] cellranger_1.1.0    jquerylib_0.1.3     vctrs_0.3.6        
 [40] Biostrings_2.58.0   rhdf5filters_1.2.0  multtest_2.46.0    
 [43] svglite_2.0.0       ape_5.4-1           nlme_3.1-152       
 [46] iterators_1.0.13    xfun_0.21           ps_1.6.0           
 [49] openxlsx_4.2.3      rvest_1.0.0         lifecycle_1.0.0    
 [52] statmod_1.4.35      zlibbioc_1.36.0     scales_1.1.1       
 [55] hms_1.0.0           promises_1.2.0.1    parallel_4.0.5     
 [58] biomformat_1.18.0   rhdf5_2.34.0        curl_4.3           
 [61] yaml_2.2.1          sass_0.3.1          stringi_1.5.3      
 [64] highr_0.8           S4Vectors_0.28.1    foreach_1.5.1      
 [67] BiocGenerics_0.36.0 zip_2.1.1           boot_1.3-27        
 [70] systemfonts_1.0.1   rlang_0.4.10        pkgconfig_2.0.3    
 [73] evaluate_0.14       Rhdf5lib_1.12.1     labeling_0.4.2     
 [76] tidyselect_1.1.0    plyr_1.8.6          magrittr_2.0.1     
 [79] R6_2.5.0            IRanges_2.24.1      generics_0.1.0     
 [82] DBI_1.1.1           foreign_0.8-81      pillar_1.5.1       
 [85] haven_2.3.1         withr_2.4.1         mgcv_1.8-34        
 [88] abind_1.4-5         survival_3.2-10     modelr_0.1.8       
 [91] crayon_1.4.1        utf8_1.1.4          rmarkdown_2.7      
 [94] progress_1.2.2      grid_4.0.5          git2r_0.28.0       
 [97] webshot_0.5.2       reprex_1.0.0        digest_0.6.27      
[100] httpuv_1.5.5        numDeriv_2016.8-1.1 stats4_4.0.5       
[103] munsell_0.5.0       bslib_0.2.4