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File Version Author Date Message
Rmd ea63e54 noah-padgett 2021-04-15 updated picrust results
html ea63e54 noah-padgett 2021-04-15 updated picrust results 
i. Mean relative abundance in Tumors

ii. Standard error of mean in Tumors

iii. Mean relative abundance in Non-tumors

iv. Standard error of mean in Non-tumors

v. GLM differential abundance analysis between Tumor vs Non-tumor (Patient=Fixed effect)
  1. P-value
  2. FDR corrected q-value
vi. GLMM differential abundance analysis between Tumor vs Non-tumor (Patient=Random Effect)
  1.P-value
  2. FDR corrected q-value

Part 1 EC Data

# note: must rename function to func (or something else) because "function" is a reserved name in R and can't be used.

descriptions <- readr::read_tsv("data/PICRUST/ec_pred_metagenome_unstrat_descrip.tsv")[,1:2] %>%
  distinct()

-- Column specification --------------------------------------------------------
cols(
  .default = col_double(),
  `function` = col_character(),
  description = col_character()
)
i Use `spec()` for the full column specifications.
colnames(descriptions) <- c("func", "description")

pi.dat <- readxl::read_xlsx("data/PICRUST-Stratified/EC_prevo.xlsx")
colnames(pi.dat) <- c("func",  colnames(pi.dat)[-c(1)])

# add descriptions to dataframe
pi.dat <- left_join(pi.dat, descriptions, by="func")
pi.dat <- pi.dat[,c(1,161,3:160)]

# aggregate descriptions to get 1 description per row - unique;y defined.
pi.dat <- pi.dat %>%
  group_by(description) %>%
  summarise(across(`1.S37.Jun172016`:`99.D01.S37.Jun232016`,.fns = sum))

# make long format
pi.dat <- pi.dat %>%
  pivot_longer(
    cols=`1.S37.Jun172016`:`99.D01.S37.Jun232016`,
    names_to = "ID",
    values_to = "Abundance"
  )
d <- as.data.frame(dat.16s)
mydata <- full_join(pi.dat, d)
Joining, by = "ID"
Warning in class(x) <- c(setdiff(subclass, tibble_class), tibble_class): Setting
class(x) to multiple strings ("tbl_df", "tbl", ...); result will no longer be an
S4 object
mydata <- mydata %>%
  mutate(
    ID.n = as.numeric(as.factor(ID)),
    description.n = as.numeric(as.factor(description))
  ) %>%
  group_by(ID) %>%
  mutate(
    dem = ifelse(sum(Abundance)==0, 1, sum(Abundance)),
    RelAbundance = Abundance/dem*100) %>%
  ungroup()%>%
  group_by(description)%>%
  mutate(avgRA = mean(RelAbundance))

Abundance

I needed to change from relative abundance to abundance due to so many individuals having 0 counts for all descriptions.

d <- mydata %>%
  filter(description=="DNA-directed DNA polymerase")

t.test(d$RelAbundance ~ d$tumor.cat)

    Welch Two Sample t-test

data:  d$RelAbundance by d$tumor.cat
t = -1.61, df = 147, p-value = 0.11
alternative hypothesis: true difference in means is not equal to 0
95 percent confidence interval:
 -0.42507  0.04277
sample estimates:
mean in group Non-Tumor     mean in group Tumor 
                 1.1167                  1.3079 
# Run on all descriptions
tb.ra1 <- mydata %>%
  group_by(description) %>%
  summarise(ng = n(),
            Overall.M = mean(RelAbundance),
            Overall.SE = sd(RelAbundance)/sqrt(ng))
tb.ra2m <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(M = mean(RelAbundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = M)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra2se <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(),SE = sd(RelAbundance)/sqrt(ng)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = SE)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra2var <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(), VAR = var(RelAbundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = VAR)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra2ng <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n()) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = ng)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra <- left_join(tb.ra1, tb.ra2m)
Joining, by = "description"
tb.ra <- cbind(tb.ra, tb.ra2se[,-1])
tb.ra <- cbind(tb.ra, tb.ra2var[,-1])
tb.ra <- cbind(tb.ra, tb.ra2ng[,-1]) 

colnames(tb.ra) <- c("description", "ng", "Overall Mean", "Overall SE", "Non-Tumor Mean", "Tumor Mean", "Non-Tumor SE", "Tumor SE","Non-Tumor Var", "Tumor Var", "Non-Tumor Ng", "Tumor Ng")
tb.ra <- tb.ra %>%
  arrange(desc(`Overall Mean`))
tb.ra <- tb.ra[, c("description", "Overall Mean", "Overall SE","Tumor Mean","Tumor Var", "Tumor SE","Tumor Ng", "Non-Tumor Mean","Non-Tumor Var", "Non-Tumor SE", "Non-Tumor Ng")]

# compute t-test
tb.ra <- tb.ra %>%
  mutate(
    SEpooled = sqrt(`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`),
    t = (`Tumor Mean` - `Non-Tumor Mean`)/(SEpooled),
    df = ((`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`)**2)/(((`Tumor Var`/`Tumor Ng`)**2)/(`Tumor Ng`-1) + ((`Non-Tumor Var`/`Non-Tumor Ng`)**2)/(`Non-Tumor Ng`-1)),
    p = pt(q = abs(t), df=df, lower.tail = F)*2,
    fdr_p = p.adjust(p, method="fdr")
  )


kable(tb.ra, format="html", digits=5, caption="Stratefied EC Data - Prevotella spp. (genus level only): Average RelAbundance of Each Description (sorted in descending order)") %>%
  kable_styling(full_width = T) %>%
  scroll_box(width = "100%", height="600px")
Stratefied EC Data - Prevotella spp. (genus level only): Average RelAbundance of Each Description (sorted in descending order)
description Overall Mean Overall SE Tumor Mean Tumor Var Tumor SE Tumor Ng Non-Tumor Mean Non-Tumor Var Non-Tumor SE Non-Tumor Ng SEpooled t df p fdr_p
NADH:ubiquinone reductase (H(+)-translocating) 1.31524 0.06542 1.43681 0.58016 0.09447 65 1.23027 0.73253 0.08875 93 0.12962 1.59341 147.105 0.11322 0.22225
DNA helicase 1.27066 0.06326 1.38024 0.53715 0.09091 65 1.19407 0.69089 0.08619 93 0.12527 1.48620 147.735 0.13936 0.25058
Peptidylprolyl isomerase 1.25121 0.06244 1.37574 0.53377 0.09062 65 1.16417 0.66135 0.08433 93 0.12379 1.70914 146.443 0.08954 0.22225
DNA-directed DNA polymerase 1.19536 0.05968 1.30787 0.48665 0.08653 65 1.11672 0.60663 0.08076 93 0.11836 1.61493 146.658 0.10848 0.22225
2-oxoglutarate synthase 0.75694 0.03781 0.82018 0.19183 0.05433 65 0.71273 0.24720 0.05156 93 0.07490 1.43463 147.798 0.15350 0.26690
DNA topoisomerase 0.54874 0.03003 0.59546 0.12760 0.04431 65 0.51609 0.15177 0.04040 93 0.05996 1.32379 144.952 0.18766 0.30606
2-oxoacid oxidoreductase (ferredoxin) 0.49389 0.02500 0.53282 0.08437 0.03603 65 0.46668 0.10797 0.03407 93 0.04959 1.33376 147.566 0.18434 0.30321
Site-specific DNA-methyltransferase (adenine-specific) 0.47921 0.02528 0.51718 0.08530 0.03623 65 0.45267 0.11122 0.03458 93 0.05008 1.28794 148.186 0.19977 0.32220
Type I site-specific deoxyribonuclease 0.42086 0.02698 0.43782 0.11246 0.04160 65 0.40901 0.11768 0.03557 93 0.05473 0.52639 139.822 0.59945 0.69416
Beta-galactosidase 0.40945 0.02341 0.43686 0.07635 0.03427 65 0.39028 0.09374 0.03175 93 0.04672 0.99706 146.115 0.32038 0.43845
Alpha-L-fucosidase 0.40586 0.02201 0.43435 0.06588 0.03184 65 0.38595 0.08381 0.03002 93 0.04376 1.10621 147.363 0.27044 0.40253
DNA-directed RNA polymerase 0.39996 0.02003 0.43885 0.05537 0.02919 65 0.37278 0.06781 0.02700 93 0.03976 1.66180 146.025 0.09870 0.22225
23S rRNA pseudouridine(1911/1915/1917) synthase 0.39457 0.01963 0.43104 0.05221 0.02834 65 0.36908 0.06593 0.02663 93 0.03889 1.59341 147.105 0.11322 0.22225
C-terminal processing peptidase 0.39457 0.01963 0.43104 0.05221 0.02834 65 0.36908 0.06593 0.02663 93 0.03889 1.59341 147.105 0.11322 0.22225
Beta-N-acetylhexosaminidase 0.37051 0.02348 0.40339 0.08646 0.03647 65 0.34752 0.08718 0.03062 93 0.04762 1.17335 138.236 0.24267 0.37372
Long-chain-fatty-acid–CoA ligase 0.36482 0.01875 0.39036 0.04622 0.02667 65 0.34697 0.06182 0.02578 93 0.03709 1.16969 149.002 0.24399 0.37472
[Formate-C-acetyltransferase]-activating enzyme 0.35029 0.01795 0.38326 0.04396 0.02601 65 0.32725 0.05503 0.02433 93 0.03561 1.57263 146.805 0.11796 0.22842
Ribonucleoside-diphosphate reductase 0.31527 0.01747 0.35311 0.04417 0.02607 65 0.28883 0.04985 0.02315 93 0.03486 1.84371 142.922 0.06730 0.22225
Glutathione peroxidase 0.30699 0.01633 0.33469 0.03788 0.02414 65 0.28763 0.04465 0.02191 93 0.03260 1.44346 144.610 0.15105 0.26607
Undecaprenyl-diphosphate phosphatase 0.29978 0.01534 0.32305 0.03138 0.02197 65 0.28352 0.04100 0.02100 93 0.03039 1.30064 148.249 0.19540 0.31602
Alpha-amylase 0.28930 0.01515 0.31881 0.03192 0.02216 65 0.26867 0.03865 0.02038 93 0.03011 1.66497 145.606 0.09807 0.22225
S-adenosylmethionine:tRNA ribosyltransferase-isomerase 0.26844 0.01354 0.29517 0.02567 0.01987 65 0.24975 0.03070 0.01817 93 0.02693 1.68701 145.154 0.09375 0.22225
H(+)-transporting two-sector ATPase 0.26619 0.01332 0.28820 0.02337 0.01896 65 0.25081 0.03102 0.01826 93 0.02633 1.42001 148.764 0.15770 0.27184
Peroxiredoxin 0.26584 0.01334 0.28951 0.02403 0.01923 65 0.24930 0.03058 0.01813 93 0.02643 1.52172 147.373 0.13022 0.23785
Carbamoyl-phosphate synthase (glutamine-hydrolyzing) 0.26498 0.01320 0.29007 0.02375 0.01911 65 0.24744 0.02968 0.01786 93 0.02616 1.62961 146.746 0.10533 0.22225
GTP diphosphokinase 0.26463 0.01318 0.28930 0.02361 0.01906 65 0.24739 0.02967 0.01786 93 0.02612 1.60449 146.937 0.11075 0.22225
Mannose-1-phosphate guanylyltransferase 0.26337 0.01310 0.28814 0.02335 0.01895 65 0.24605 0.02930 0.01775 93 0.02597 1.62068 146.893 0.10723 0.22225
Acyl-[acyl-carrier-protein]–UDP-N-acetylglucosamine O-acyltransferase 0.26305 0.01308 0.28736 0.02321 0.01889 65 0.24605 0.02930 0.01775 93 0.02592 1.59341 147.105 0.11322 0.22225
Dipeptidyl-peptidase IV 0.26305 0.01308 0.28736 0.02321 0.01889 65 0.24605 0.02930 0.01775 93 0.02592 1.59341 147.105 0.11322 0.22225
DNA topoisomerase (ATP-hydrolyzing) 0.26305 0.01308 0.28736 0.02321 0.01889 65 0.24605 0.02930 0.01775 93 0.02592 1.59341 147.105 0.11322 0.22225
Exodeoxyribonuclease VII 0.26305 0.01308 0.28736 0.02321 0.01889 65 0.24605 0.02930 0.01775 93 0.02592 1.59341 147.105 0.11322 0.22225
Fumarate reductase (quinol) 0.26305 0.01308 0.28736 0.02321 0.01889 65 0.24605 0.02930 0.01775 93 0.02592 1.59341 147.105 0.11322 0.22225
IMP cyclohydrolase 0.26305 0.01308 0.28736 0.02321 0.01889 65 0.24605 0.02930 0.01775 93 0.02592 1.59341 147.105 0.11322 0.22225
Phenylalanine–tRNA ligase 0.26305 0.01308 0.28736 0.02321 0.01889 65 0.24605 0.02930 0.01775 93 0.02592 1.59341 147.105 0.11322 0.22225
Phosphoribosylaminoimidazolecarboxamide formyltransferase 0.26305 0.01308 0.28736 0.02321 0.01889 65 0.24605 0.02930 0.01775 93 0.02592 1.59341 147.105 0.11322 0.22225
Ribonuclease H 0.26305 0.01308 0.28736 0.02321 0.01889 65 0.24605 0.02930 0.01775 93 0.02592 1.59341 147.105 0.11322 0.22225
Succinate dehydrogenase (quinone) 0.26305 0.01308 0.28736 0.02321 0.01889 65 0.24605 0.02930 0.01775 93 0.02592 1.59341 147.105 0.11322 0.22225
tRNA dimethylallyltransferase 0.26305 0.01308 0.28736 0.02321 0.01889 65 0.24605 0.02930 0.01775 93 0.02592 1.59341 147.105 0.11322 0.22225
Uridine kinase 0.26305 0.01308 0.28736 0.02321 0.01889 65 0.24605 0.02930 0.01775 93 0.02592 1.59341 147.105 0.11322 0.22225
XTP/dITP diphosphatase 0.26305 0.01308 0.28736 0.02321 0.01889 65 0.24605 0.02930 0.01775 93 0.02592 1.59341 147.105 0.11322 0.22225
Xaa-Pro aminopeptidase 0.26200 0.01307 0.28485 0.02318 0.01888 65 0.24602 0.02929 0.01775 93 0.02592 1.49854 147.131 0.13613 0.24787
5’-nucleotidase 0.25993 0.01298 0.28443 0.02293 0.01878 65 0.24281 0.02874 0.01758 93 0.02573 1.61809 146.846 0.10779 0.22225
Bleomycin hydrolase 0.25835 0.01291 0.28250 0.02269 0.01868 65 0.24147 0.02847 0.01750 93 0.02560 1.60278 146.884 0.11113 0.22225
DNA (cytosine-5-)-methyltransferase 0.25690 0.01515 0.27995 0.03447 0.02303 65 0.24078 0.03728 0.02002 93 0.03052 1.28362 141.201 0.20138 0.32298
Pyridoxal 5’-phosphate synthase (glutamine hydrolyzing) 0.25682 0.01303 0.28151 0.02326 0.01892 65 0.23956 0.02889 0.01762 93 0.02585 1.62225 146.526 0.10690 0.22225
Phosphoglycerate mutase (2,3-diphosphoglycerate-independent) 0.25506 0.01408 0.26873 0.02734 0.02051 65 0.24552 0.03424 0.01919 93 0.02808 0.82654 146.819 0.40984 0.53325
Phosphoglycolate phosphatase 0.25456 0.01353 0.27916 0.02652 0.02020 65 0.23737 0.03017 0.01801 93 0.02706 1.54419 143.238 0.12475 0.23196
Peptidyl-dipeptidase Dcp 0.25241 0.01308 0.27698 0.02417 0.01928 65 0.23524 0.02861 0.01754 93 0.02607 1.60113 144.770 0.11153 0.22225
Coproporphyrinogen dehydrogenase 0.25017 0.01274 0.27182 0.02251 0.01861 65 0.23503 0.02757 0.01722 93 0.02535 1.45116 146.021 0.14888 0.26524
Dephospho-CoA kinase 0.24817 0.01256 0.27105 0.02146 0.01817 65 0.23218 0.02698 0.01703 93 0.02490 1.56087 146.948 0.12071 0.23069
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 0.24625 0.01248 0.26719 0.02119 0.01805 65 0.23162 0.02671 0.01695 93 0.02476 1.43634 147.050 0.15303 0.26690
Aldose 1-epimerase 0.24621 0.01249 0.26468 0.02106 0.01800 65 0.23331 0.02698 0.01703 93 0.02478 1.26589 147.605 0.20755 0.32833
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase 0.24568 0.01243 0.26525 0.02088 0.01792 65 0.23200 0.02670 0.01694 93 0.02466 1.34791 147.538 0.17975 0.29652
Methionyl aminopeptidase 0.24039 0.01230 0.26134 0.02080 0.01789 65 0.22576 0.02578 0.01665 93 0.02444 1.45601 146.454 0.14753 0.26364
Aspartate kinase 0.22979 0.01190 0.24660 0.01916 0.01717 65 0.21805 0.02449 0.01623 93 0.02362 1.20846 147.511 0.22880 0.35908
Thiamine-phosphate diphosphorylase 0.22949 0.01571 0.26310 0.03808 0.02420 65 0.20600 0.03872 0.02041 93 0.03166 1.80390 138.602 0.07342 0.22225
Glycerol-3-phosphate dehydrogenase 0.22509 0.01704 0.24874 0.04274 0.02564 65 0.20856 0.04790 0.02270 93 0.03424 1.17314 142.645 0.24270 0.37372
Fructokinase 0.22493 0.01183 0.24048 0.01942 0.01728 65 0.21407 0.02391 0.01603 93 0.02358 1.12021 146.213 0.26446 0.39772
Sialate O-acetylesterase 0.22155 0.01351 0.23055 0.02458 0.01945 65 0.21526 0.03202 0.01856 93 0.02688 0.56898 148.155 0.57023 0.67243
Aspartate transaminase 0.22082 0.01255 0.23782 0.02236 0.01855 65 0.20894 0.02654 0.01689 93 0.02509 1.15106 144.866 0.25160 0.38336
Glucosamine-6-phosphate deaminase 0.21876 0.01245 0.23740 0.02208 0.01843 65 0.20573 0.02605 0.01674 93 0.02490 1.27211 144.642 0.20538 0.32579
Leucine–tRNA ligase 0.21497 0.01138 0.23270 0.01785 0.01657 65 0.20258 0.02212 0.01542 93 0.02264 1.33024 146.458 0.18551 0.30364
Glutamate–ammonia ligase 0.20693 0.01103 0.22563 0.01726 0.01630 65 0.19386 0.02039 0.01481 93 0.02202 1.44298 144.688 0.15119 0.26607
Non-specific serine/threonine protein kinase 0.20554 0.01545 0.22919 0.03762 0.02406 65 0.18901 0.03751 0.02008 93 0.03134 1.28219 137.750 0.20193 0.32298
Uracil-DNA glycosylase 0.20190 0.01099 0.21993 0.01697 0.01616 65 0.18929 0.02036 0.01480 93 0.02191 1.39808 145.271 0.16422 0.28014
Glutamate dehydrogenase (NADP(+)) 0.19792 0.01085 0.21825 0.01690 0.01612 65 0.18372 0.01950 0.01448 93 0.02167 1.59352 143.805 0.11324 0.22225
Glycine dehydrogenase (aminomethyl-transferring) 0.19667 0.01254 0.21339 0.02399 0.01921 65 0.18498 0.02537 0.01652 93 0.02534 1.12160 140.261 0.26395 0.39772
Succinate–CoA ligase (ADP-forming) 0.19002 0.01230 0.20732 0.02325 0.01891 65 0.17793 0.02426 0.01615 93 0.02487 1.18177 139.709 0.23930 0.37147
Beta-glucosidase 0.18843 0.01915 0.17968 0.04865 0.02736 65 0.19454 0.06496 0.02643 93 0.03804 -0.39072 148.951 0.69656 0.77560
Hydroxymethylpyrimidine kinase 0.18621 0.01054 0.20880 0.01665 0.01600 65 0.17042 0.01778 0.01383 93 0.02115 1.81471 140.683 0.07170 0.22225
Phosphomethylpyrimidine kinase 0.18621 0.01054 0.20880 0.01665 0.01600 65 0.17042 0.01778 0.01383 93 0.02115 1.81471 140.683 0.07170 0.22225
Serine O-acetyltransferase 0.18128 0.01054 0.19925 0.01615 0.01576 65 0.16871 0.01833 0.01404 93 0.02111 1.44679 143.154 0.15014 0.26607
Signal peptidase I 0.17830 0.01102 0.19862 0.02023 0.01764 65 0.16410 0.01817 0.01398 93 0.02251 1.53344 133.085 0.12754 0.23443
3-oxoacyl-[acyl-carrier-protein] reductase 0.17707 0.00962 0.18460 0.01170 0.01342 65 0.17181 0.01674 0.01342 93 0.01897 0.67408 150.964 0.50129 0.61233
Fumarate hydratase 0.17270 0.01097 0.19072 0.01794 0.01661 65 0.16011 0.01958 0.01451 93 0.02206 1.38772 141.565 0.16740 0.28014
3-hydroxyacyl-[acyl-carrier-protein] dehydratase 0.17019 0.00923 0.17711 0.01056 0.01274 65 0.16535 0.01555 0.01293 93 0.01816 0.64816 151.730 0.51786 0.62597
Alpha-galactosidase 0.16998 0.01108 0.18309 0.01759 0.01645 65 0.16082 0.02066 0.01491 93 0.02220 1.00322 144.483 0.31743 0.43845
DNA-(apurinic or apyrimidinic site) lyase 0.16895 0.00926 0.18686 0.01238 0.01380 65 0.15643 0.01413 0.01233 93 0.01850 1.64511 143.375 0.10214 0.22225
Exodeoxyribonuclease III 0.16895 0.00926 0.18686 0.01238 0.01380 65 0.15643 0.01413 0.01233 93 0.01850 1.64511 143.375 0.10214 0.22225
Glucokinase 0.16874 0.00946 0.18300 0.01311 0.01420 65 0.15878 0.01478 0.01260 93 0.01899 1.27551 142.870 0.20420 0.32481
Asparaginase 0.16639 0.00926 0.18087 0.01215 0.01367 65 0.15627 0.01443 0.01246 93 0.01849 1.32988 144.920 0.18565 0.30364
Serine-type D-Ala-D-Ala carboxypeptidase 0.15720 0.00852 0.16929 0.00979 0.01227 65 0.14875 0.01260 0.01164 93 0.01691 1.21410 147.758 0.22665 0.35757
O-acetylhomoserine aminocarboxypropyltransferase 0.15553 0.01046 0.16240 0.01587 0.01563 65 0.15072 0.01842 0.01407 93 0.02103 0.55497 144.006 0.57977 0.67953
UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) 0.15516 0.00856 0.16687 0.00948 0.01208 65 0.14698 0.01298 0.01181 93 0.01690 1.17734 149.705 0.24093 0.37299
Acid phosphatase 0.15166 0.01170 0.16649 0.02111 0.01802 65 0.14130 0.02197 0.01537 93 0.02368 1.06392 139.586 0.28920 0.41967
2’,3’-cyclic-nucleotide 2’-phosphodiesterase 0.15127 0.00807 0.16172 0.00857 0.01148 65 0.14397 0.01146 0.01110 93 0.01597 1.11142 149.010 0.26818 0.40019
3’-nucleotidase 0.15127 0.00807 0.16172 0.00857 0.01148 65 0.14397 0.01146 0.01110 93 0.01597 1.11142 149.010 0.26818 0.40019
1-deoxy-D-xylulose-5-phosphate synthase 0.15048 0.00815 0.16622 0.00996 0.01238 65 0.13948 0.01069 0.01072 93 0.01638 1.63320 140.871 0.10466 0.22225
N-acetylmuramoyl-L-alanine amidase 0.14847 0.00807 0.16052 0.00894 0.01173 65 0.14004 0.01116 0.01096 93 0.01605 1.27613 146.725 0.20393 0.32481
Mannan endo-1,4-beta-mannosidase 0.14690 0.01095 0.14658 0.01464 0.01501 65 0.14713 0.02216 0.01544 93 0.02153 -0.02577 152.403 0.97947 0.97947
Beta-ketoacyl-[acyl-carrier-protein] synthase III 0.14634 0.00806 0.16469 0.01083 0.01291 65 0.13350 0.00956 0.01014 93 0.01641 1.90036 132.300 0.05956 0.22225
Cadmium-exporting ATPase 0.14419 0.00787 0.16093 0.00957 0.01213 65 0.13249 0.00972 0.01022 93 0.01587 1.79231 138.576 0.07527 0.22225
Dihydrofolate reductase 0.14419 0.00787 0.16093 0.00957 0.01213 65 0.13249 0.00972 0.01022 93 0.01587 1.79231 138.576 0.07527 0.22225
GTP cyclohydrolase I 0.14419 0.00787 0.16093 0.00957 0.01213 65 0.13249 0.00972 0.01022 93 0.01587 1.79231 138.576 0.07527 0.22225
Zinc-exporting ATPase 0.14419 0.00787 0.16093 0.00957 0.01213 65 0.13249 0.00972 0.01022 93 0.01587 1.79231 138.576 0.07527 0.22225
8-oxo-dGTP diphosphatase 0.14331 0.01023 0.15438 0.01629 0.01583 65 0.13558 0.01672 0.01341 93 0.02075 0.90634 138.994 0.36632 0.48647
Cu(2+)-exporting ATPase 0.14329 0.00767 0.15706 0.00807 0.01114 65 0.13366 0.01001 0.01037 93 0.01522 1.53766 146.494 0.12629 0.23361
Methionine synthase 0.14305 0.00983 0.15178 0.01518 0.01528 65 0.13695 0.01537 0.01286 93 0.01997 0.74295 138.413 0.45877 0.57998
Glutamate synthase (NADH) 0.14154 0.00833 0.14871 0.00960 0.01216 65 0.13654 0.01196 0.01134 93 0.01662 0.73214 146.631 0.46525 0.58434
Glutamate synthase (NADPH) 0.14154 0.00833 0.14871 0.00960 0.01216 65 0.13654 0.01196 0.01134 93 0.01662 0.73214 146.631 0.46525 0.58434
D-Ala-D-Ala dipeptidase 0.14098 0.00800 0.15580 0.01023 0.01254 65 0.13063 0.00989 0.01031 93 0.01624 1.55015 136.396 0.12342 0.23196
Triose-phosphate isomerase 0.13928 0.00722 0.15330 0.00750 0.01074 65 0.12948 0.00859 0.00961 93 0.01441 1.65315 143.515 0.10049 0.22225
3-deoxy-manno-octulosonate cytidylyltransferase 0.13921 0.00722 0.15285 0.00741 0.01068 65 0.12967 0.00869 0.00967 93 0.01440 1.60931 144.393 0.10973 0.22225
Methionine adenosyltransferase 0.13921 0.00722 0.15285 0.00741 0.01068 65 0.12967 0.00869 0.00967 93 0.01440 1.60931 144.393 0.10973 0.22225
Cob(I)yrinic acid a,c-diamide adenosyltransferase 0.13912 0.00828 0.14917 0.01019 0.01252 65 0.13210 0.01125 0.01100 93 0.01667 1.02447 142.039 0.30735 0.43845
Dihydroorotase 0.13691 0.00714 0.15149 0.00757 0.01079 65 0.12672 0.00823 0.00941 93 0.01432 1.73024 141.440 0.08577 0.22225
Endopeptidase La 0.13691 0.00714 0.15149 0.00757 0.01079 65 0.12672 0.00823 0.00941 93 0.01432 1.73024 141.440 0.08577 0.22225
Isoleucine–tRNA ligase 0.13691 0.00714 0.15149 0.00757 0.01079 65 0.12672 0.00823 0.00941 93 0.01432 1.73024 141.440 0.08577 0.22225
Phosphoribosylformylglycinamidine synthase 0.13691 0.00714 0.15149 0.00757 0.01079 65 0.12672 0.00823 0.00941 93 0.01432 1.73024 141.440 0.08577 0.22225
Aspartate ammonia-lyase 0.13596 0.00756 0.14844 0.00723 0.01054 65 0.12724 0.01018 0.01046 93 0.01485 1.42750 150.544 0.15551 0.26958
23S rRNA pseudouridine(746) synthase 0.13565 0.00730 0.14895 0.00778 0.01094 65 0.12636 0.00875 0.00970 93 0.01462 1.54553 142.761 0.12443 0.23196
tRNA pseudouridine(32) synthase 0.13565 0.00730 0.14895 0.00778 0.01094 65 0.12636 0.00875 0.00970 93 0.01462 1.54553 142.761 0.12443 0.23196
UDP-glucose 4-epimerase 0.13496 0.00690 0.14738 0.00648 0.00998 65 0.12627 0.00814 0.00936 93 0.01368 1.54295 146.936 0.12499 0.23196
Transketolase 0.13469 0.00682 0.14755 0.00647 0.00997 65 0.12570 0.00785 0.00918 93 0.01356 1.61166 145.688 0.10920 0.22225
16S rRNA (cytidine(1402)-2’-O)-methyltransferase 0.13464 0.00688 0.14661 0.00639 0.00992 65 0.12627 0.00814 0.00936 93 0.01363 1.49157 147.395 0.13795 0.24960
3’(2’),5’-bisphosphate nucleotidase 0.13464 0.00688 0.14661 0.00639 0.00992 65 0.12627 0.00814 0.00936 93 0.01363 1.49157 147.395 0.13795 0.24960
3-deoxy-manno-octulosonate-8-phosphatase 0.13311 0.00665 0.14562 0.00605 0.00964 65 0.12436 0.00753 0.00900 93 0.01319 1.61107 146.640 0.10931 0.22225
Amidophosphoribosyltransferase 0.13276 0.00663 0.14516 0.00597 0.00959 65 0.12410 0.00751 0.00898 93 0.01314 1.60303 146.932 0.11107 0.22225
UDP-glucose 6-dehydrogenase 0.13276 0.00663 0.14516 0.00597 0.00959 65 0.12410 0.00751 0.00898 93 0.01314 1.60303 146.932 0.11107 0.22225
3,4-dihydroxy-2-butanone-4-phosphate synthase 0.13260 0.00668 0.14619 0.00643 0.00994 65 0.12311 0.00734 0.00888 93 0.01333 1.73100 143.370 0.08560 0.22225
Histidine kinase 0.13258 0.00668 0.14619 0.00643 0.00994 65 0.12306 0.00733 0.00888 93 0.01333 1.73494 143.337 0.08490 0.22225
Uroporphyrinogen-III synthase 0.13254 0.00663 0.14368 0.00580 0.00945 65 0.12475 0.00767 0.00908 93 0.01311 1.44451 148.651 0.15070 0.26607
Phosphoribosylglycinamide formyltransferase 0.13244 0.00661 0.14438 0.00589 0.00952 65 0.12410 0.00751 0.00898 93 0.01309 1.55023 147.450 0.12323 0.23196
GTP cyclohydrolase II 0.13155 0.00654 0.14368 0.00580 0.00945 65 0.12308 0.00733 0.00888 93 0.01296 1.58937 147.133 0.11412 0.22289
(2E,6E)-farnesyl diphosphate synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
(Kdo)-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
(Kdo)(2)-lipid IV(A) (2-8) 3-deoxy-D-manno-octulosonic acid transferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
(Kdo)(3)-lipid IV(A) (2-4) 3-deoxy-D-manno-octulosonic acid transferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
[Acyl-carrier-protein] S-malonyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
[Ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
1-acylglycerol-3-phosphate O-acyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
1-deoxy-D-xylulose-5-phosphate reductoisomerase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
1,4-alpha-glucan branching enzyme 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
1,4-dihydroxy-2-naphthoate polyprenyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
1,4-dihydroxy-2-naphthoyl-CoA synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
16S rRNA (cytosine(1402)-N(4))-methyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
16S rRNA (guanine(527)-N(7))-methyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
16S rRNA (uracil(1498)-N(3))-methyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
2-iminobutanoate/2-iminopropanoate deaminase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
23S rRNA (adenine(2503)-C(2))-methyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
23S rRNA (cytosine(1962)-C(5))-methyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
23S rRNA (pseudouridine(1915)-N(3))-methyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
23S rRNA (uracil(1939)-C(5))-methyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
23S rRNA pseudouridine(2605) synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
3-dehydroquinate dehydratase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
3-dehydroquinate synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
3-deoxy-8-phosphooctulonate synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
3-phosphoshikimate 1-carboxyvinyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol kinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
4-alpha-glucanotransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
4-hydroxy-3-methylbut-2-enyl diphosphate reductase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
4-hydroxy-tetrahydrodipicolinate reductase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
4-hydroxy-tetrahydrodipicolinate synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
4-hydroxythreonine-4-phosphate dehydrogenase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
5-(carboxyamino)imidazole ribonucleotide mutase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
5-amino-6-(5-phosphoribosylamino)uracil reductase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
5-formyltetrahydrofolate cyclo-ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
6-phosphofructokinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
6,7-dimethyl-8-ribityllumazine synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
7-cyano-7-deazaguanine synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Acetate kinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
acetylglucosaminyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Adenine phosphoribosyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Adenosylhomocysteine nucleosidase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Adenylate kinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Adenylosuccinate lyase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Adenylosuccinate synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Alanine–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Alanine racemase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
All-trans-octaprenyl-diphosphate synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Aminoacyl-tRNA hydrolase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Arabinose-5-phosphate isomerase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Arginine–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Arginine decarboxylase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Asparagine–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Aspartate–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Aspartate-semialdehyde dehydrogenase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Aspartate carbamoyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Beta-ketoacyl-[acyl-carrier-protein] synthase II 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Biotin–[acetyl-CoA-carboxylase] ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Branched-chain-amino-acid transaminase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Carboxynorspermidine decarboxylase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
CDP-diacylglycerol–serine O-phosphatidyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Chorismate mutase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Chorismate synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Crossover junction endodeoxyribonuclease 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
CTP synthase (glutamine hydrolyzing) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Cysteine–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Cysteine desulfurase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Cytidine deaminase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
D-alanine–D-alanine ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
dCMP deaminase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Demethylmenaquinone methyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Deoxyribose-phosphate aldolase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
dGTPase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Diamine N-acetyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Diaminohydroxyphosphoribosylaminopyrimidine deaminase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Dihydrofolate synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Dihydroneopterin aldolase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Dihydroorotate dehydrogenase (NAD(+)) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Dihydropteroate synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Dimethylallyltranstransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Dipeptidyl-peptidase III 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Diphosphate–fructose-6-phosphate 1-phosphotransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
diphosphate specific) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
DNA ligase (NAD(+)) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Dolichyl-phosphate beta-D-mannosyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
dTDP-4-dehydrorhamnose 3,5-epimerase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
dTDP-4-dehydrorhamnose reductase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
dTDP-glucose 4,6-dehydratase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
dUTP diphosphatase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Endopeptidase Clp 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Epoxyqueuosine reductase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
FAD synthetase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
FMN reductase (NAD(P)H) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Fructose-bisphosphatase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Fructose-bisphosphate aldolase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
GDP-L-fucose synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
GDP-mannose 4,6-dehydratase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Geranylgeranyl diphosphate synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Glucose-1-phosphate thymidylyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Glucose-6-phosphate isomerase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Glutamate–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Glutamate racemase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Glutamine–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Glycerate dehydrogenase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Glycine–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Glycine hydroxymethyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Glycogen phosphorylase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
GMP synthase (glutamine-hydrolyzing) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Guanylate kinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Histidine–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Hypoxanthine phosphoribosyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
IMP dehydrogenase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Iron-chelate-transporting ATPase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Isochorismate synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Kdo(2)-lipid IV(A) lauroyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
L-serine ammonia-lyase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
L-threonylcarbamoyladenylate synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Lipid-A-disaccharide synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Lysine–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Malate dehydrogenase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Mannose-6-phosphate isomerase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Methenyltetrahydrofolate cyclohydrolase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Methionine–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Methionyl-tRNA formyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Methylated-DNA–[protein]-cysteine S-methyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Methylenetetrahydrofolate dehydrogenase (NADP(+)) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
N-carbamoylputrescine amidase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
N(6)-L-threonylcarbamoyladenine synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
NAD(+) diphosphatase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
NAD(+) kinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
NAD(+) synthase (glutamine-hydrolyzing) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
NAD(P)H-hydrate epimerase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Nicotinamide-nucleotide amidase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Nicotinate-nucleotide adenylyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Oligonucleotidase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Orotate phosphoribosyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Orotidine-5’-phosphate decarboxylase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Pantetheine-phosphate adenylyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Pantothenate kinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Peptide-methionine (R)-S-oxide reductase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Peptide-methionine (S)-S-oxide reductase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Peptide chain release factor N(5)-glutamine methyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Peptide deformylase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Phosphate acetyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Phosphatidate cytidylyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Phosphatidylserine decarboxylase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Phospho-N-acetylmuramoyl-pentapeptide-transferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Phosphoenolpyruvate carboxykinase (ATP) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Phosphoglycerate kinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Phosphomannomutase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Phosphopyruvate hydratase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Phosphoribosylamine–glycine ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Phosphoribosylaminoimidazolesuccinocarboxamide synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Phosphoribosylformylglycinamidine cyclo-ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Polyribonucleotide nucleotidyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
PreQ(1) synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Proline–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Protein-disulfide reductase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Purine-nucleoside phosphorylase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Pyruvate carboxylase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Pyruvate kinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Pyruvate synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Pyruvate, phosphate dikinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Riboflavin kinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Riboflavin synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Ribonuclease P 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Ribonuclease Z 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Ribonucleoside-triphosphate reductase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Ribose-5-phosphate isomerase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Ribose-phosphate diphosphokinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Ribulose-phosphate 3-epimerase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
RNA helicase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Saccharopine dehydrogenase (NAD(+), L-lysine-forming) 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Selenocysteine lyase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Serine–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Shikimate dehydrogenase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Shikimate kinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Signal peptidase II 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Starch synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Tetraacyldisaccharide 4’-kinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Tetrahydrofolate synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Thiamine-phosphate kinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Thioredoxin-disulfide reductase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Threonine–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Thymidine kinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Tripeptide aminopeptidase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
tRNA-guanine(34) transglycosylase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
tRNA (guanine(37)-N(1))-methyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
tRNA (guanine(46)-N(7))-methyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
tRNA pseudouridine(38-40) synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
tRNA pseudouridine(55) synthase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
tRNA(adenine(34)) deaminase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
tRNA(Ile)-lysidine synthetase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Tryptophan–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Tyrosine–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
UDP-2,3-diacylglucosamine diphosphatase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
UDP-3-O-acyl-N-acetylglucosamine deacetylase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
UDP-N-acetylmuramate–L-alanine ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
UDP-N-acetylmuramate dehydrogenase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
UDP-N-acetylmuramoyl-L-alanine–D-glutamate ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
UMP kinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
UMP/CMP kinase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Uracil phosphoribosyltransferase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Uridine phosphorylase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Valine–tRNA ligase 0.13152 0.00654 0.14368 0.00580 0.00945 65 0.12303 0.00733 0.00888 93 0.01296 1.59341 147.105 0.11322 0.22225
Nicotinate phosphoribosyltransferase 0.13120 0.00654 0.14291 0.00579 0.00944 65 0.12303 0.00733 0.00888 93 0.01296 1.53448 147.178 0.12706 0.23429
3-methyl-2-oxobutanoate hydroxymethyltransferase 0.13051 0.00653 0.14368 0.00580 0.00945 65 0.12130 0.00727 0.00884 93 0.01294 1.72959 146.821 0.08581 0.22225
Aspartate 1-decarboxylase 0.13051 0.00653 0.14368 0.00580 0.00945 65 0.12130 0.00727 0.00884 93 0.01294 1.72959 146.821 0.08581 0.22225
Pantoate–beta-alanine ligase (AMP-forming) 0.13051 0.00653 0.14368 0.00580 0.00945 65 0.12130 0.00727 0.00884 93 0.01294 1.72959 146.821 0.08581 0.22225
Phosphopantothenate–cysteine ligase 0.13051 0.00653 0.14368 0.00580 0.00945 65 0.12130 0.00727 0.00884 93 0.01294 1.72959 146.821 0.08581 0.22225
Phosphopantothenoylcysteine decarboxylase 0.13051 0.00653 0.14368 0.00580 0.00945 65 0.12130 0.00727 0.00884 93 0.01294 1.72959 146.821 0.08581 0.22225
Diaminopimelate dehydrogenase 0.12994 0.00650 0.14175 0.00573 0.00939 65 0.12169 0.00722 0.00881 93 0.01288 1.55743 147.030 0.12152 0.23069
Phosphoglycerate dehydrogenase 0.12994 0.00650 0.14175 0.00573 0.00939 65 0.12169 0.00722 0.00881 93 0.01288 1.55743 147.030 0.12152 0.23069
Phosphoserine transaminase 0.12994 0.00650 0.14175 0.00573 0.00939 65 0.12169 0.00722 0.00881 93 0.01288 1.55743 147.030 0.12152 0.23069
DNA-3-methyladenine glycosylase I 0.12967 0.00818 0.14355 0.00992 0.01235 65 0.11996 0.01089 0.01082 93 0.01642 1.43608 141.845 0.15318 0.26690
Protein-tyrosine-phosphatase 0.12922 0.00656 0.13975 0.00599 0.00960 65 0.12187 0.00732 0.00887 93 0.01307 1.36854 145.912 0.17325 0.28825
Nitrite reductase (cytochrome; ammonia-forming) 0.12914 0.00655 0.14040 0.00598 0.00959 65 0.12127 0.00726 0.00884 93 0.01304 1.46693 145.732 0.14455 0.25911
Bacterial non-heme ferritin 0.12841 0.00652 0.14075 0.00581 0.00946 65 0.11978 0.00722 0.00881 93 0.01293 1.62225 146.526 0.10690 0.22225
Enoyl-[acyl-carrier-protein] reductase (NADH) 0.12841 0.00652 0.14075 0.00581 0.00946 65 0.11978 0.00722 0.00881 93 0.01293 1.62225 146.526 0.10690 0.22225
Enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) 0.12841 0.00652 0.14075 0.00581 0.00946 65 0.11978 0.00722 0.00881 93 0.01293 1.62225 146.526 0.10690 0.22225
o-succinylbenzoate–CoA ligase 0.12841 0.00652 0.14075 0.00581 0.00946 65 0.11978 0.00722 0.00881 93 0.01293 1.62225 146.526 0.10690 0.22225
Phosphoribosylanthranilate isomerase 0.12841 0.00652 0.14075 0.00581 0.00946 65 0.11978 0.00722 0.00881 93 0.01293 1.62225 146.526 0.10690 0.22225
Ribonuclease III 0.12838 0.00661 0.14284 0.00577 0.00942 65 0.11827 0.00750 0.00898 93 0.01302 1.88826 148.110 0.06095 0.22225
Hydroxylamine reductase 0.12835 0.00663 0.14106 0.00611 0.00969 65 0.11947 0.00740 0.00892 93 0.01317 1.63906 145.626 0.10336 0.22225
Formate C-acetyltransferase 0.12788 0.00651 0.13924 0.00591 0.00954 65 0.11993 0.00715 0.00877 93 0.01296 1.48990 145.571 0.13842 0.24966
Thymidylate synthase 0.12436 0.00780 0.13995 0.00938 0.01201 65 0.11346 0.00960 0.01016 93 0.01573 1.68383 138.907 0.09446 0.22225
Pyridoxal kinase 0.12404 0.00656 0.13981 0.00577 0.00942 65 0.11302 0.00728 0.00885 93 0.01292 2.07253 147.096 0.03996 0.22225
Thiamine diphosphokinase 0.12311 0.00666 0.13730 0.00606 0.00966 65 0.11319 0.00750 0.00898 93 0.01319 1.82792 146.407 0.06960 0.22225
Galactokinase 0.12270 0.00649 0.13355 0.00607 0.00966 65 0.11512 0.00700 0.00868 93 0.01299 1.41925 143.782 0.15799 0.27184
Maltose O-acetyltransferase 0.12179 0.00694 0.13319 0.00697 0.01036 65 0.11382 0.00798 0.00926 93 0.01390 1.39377 143.496 0.16554 0.28014
Protoporphyrinogen oxidase 0.12128 0.00647 0.13168 0.00615 0.00973 65 0.11401 0.00687 0.00859 93 0.01298 1.36155 142.474 0.17549 0.29031
Formate–tetrahydrofolate ligase 0.11885 0.00645 0.12643 0.00596 0.00958 65 0.11356 0.00700 0.00868 93 0.01292 0.99605 144.472 0.32089 0.43845
S-ribosylhomocysteine lyase 0.11885 0.00645 0.12643 0.00596 0.00958 65 0.11356 0.00700 0.00868 93 0.01292 0.99605 144.472 0.32089 0.43845
Glycine C-acetyltransferase 0.11846 0.00921 0.12432 0.01230 0.01376 65 0.11436 0.01428 0.01239 93 0.01851 0.53816 144.021 0.59130 0.68747
Fructan beta-fructosidase 0.11780 0.00646 0.12392 0.00607 0.00966 65 0.11352 0.00700 0.00867 93 0.01298 0.80097 143.778 0.42447 0.54767
Glutamine–fructose-6-phosphate transaminase (isomerizing) 0.11658 0.00640 0.12527 0.00595 0.00956 65 0.11050 0.00680 0.00855 93 0.01283 1.15136 143.458 0.25150 0.38336
Pullulanase 0.11574 0.00639 0.12350 0.00587 0.00951 65 0.11031 0.00684 0.00857 93 0.01280 1.03035 144.133 0.30457 0.43662
Cystathionine beta-lyase 0.11424 0.00642 0.12004 0.00596 0.00957 65 0.11019 0.00694 0.00864 93 0.01290 0.76374 144.196 0.44627 0.56665
Tryptophan synthase 0.11201 0.00667 0.12059 0.00678 0.01022 65 0.10602 0.00720 0.00880 93 0.01348 1.08097 140.434 0.28157 0.41481
Calcium-transporting ATPase 0.11178 0.00646 0.12564 0.00591 0.00953 65 0.10208 0.00691 0.00862 93 0.01285 1.83311 144.317 0.06885 0.22225
Xanthine phosphoribosyltransferase 0.11178 0.00646 0.12564 0.00591 0.00953 65 0.10208 0.00691 0.00862 93 0.01285 1.83311 144.317 0.06885 0.22225
Histidinol-phosphate transaminase 0.11119 0.00761 0.12547 0.00963 0.01217 65 0.10121 0.00867 0.00966 93 0.01554 1.56112 133.194 0.12087 0.23069
NADH dehydrogenase 0.10992 0.00626 0.12016 0.00566 0.00933 65 0.10276 0.00651 0.00837 93 0.01253 1.38851 143.673 0.16713 0.28014
Prolyl oligopeptidase 0.10919 0.00643 0.11994 0.00599 0.00960 65 0.10167 0.00686 0.00859 93 0.01288 1.41847 143.501 0.15822 0.27184
1,4-beta-mannosyl-N-acetylglucosamine phosphorylase 0.10611 0.00622 0.11479 0.00544 0.00915 65 0.10005 0.00654 0.00838 93 0.01241 1.18814 145.316 0.23672 0.36844
Beta-1,4-mannooligosaccharide phosphorylase 0.10611 0.00622 0.11479 0.00544 0.00915 65 0.10005 0.00654 0.00838 93 0.01241 1.18814 145.316 0.23672 0.36844
Exo-alpha-sialidase 0.10611 0.00622 0.11479 0.00544 0.00915 65 0.10005 0.00654 0.00838 93 0.01241 1.18814 145.316 0.23672 0.36844
Phosphoserine phosphatase 0.10588 0.00621 0.11069 0.00590 0.00953 65 0.10252 0.00626 0.00820 93 0.01257 0.65026 140.403 0.51659 0.62597
N-acylglucosamine 2-epimerase 0.10506 0.00622 0.11229 0.00549 0.00919 65 0.10001 0.00654 0.00839 93 0.01244 0.98644 145.048 0.32556 0.44129
Nicotinamidase 0.10352 0.00641 0.12007 0.00568 0.00935 65 0.09195 0.00679 0.00855 93 0.01267 2.22025 145.147 0.02795 0.22225
Glycerate 3-kinase 0.10324 0.00626 0.11187 0.00577 0.00943 65 0.09721 0.00647 0.00834 93 0.01259 1.16435 142.641 0.24623 0.37716
Lipoyl synthase 0.10270 0.00675 0.10764 0.00616 0.00973 65 0.09925 0.00798 0.00926 93 0.01344 0.62467 147.985 0.53315 0.63648
Aspartate–ammonia ligase 0.10167 0.00606 0.10906 0.00539 0.00911 65 0.09650 0.00610 0.00810 93 0.01218 1.03020 143.011 0.30465 0.43662
N-acetylneuraminate lyase 0.10165 0.00621 0.10955 0.00562 0.00930 65 0.09613 0.00643 0.00831 93 0.01247 1.07638 143.475 0.28356 0.41481
Anthranilate synthase 0.10149 0.00677 0.11249 0.00714 0.01048 65 0.09379 0.00726 0.00883 93 0.01371 1.36425 138.581 0.17470 0.28983
Aminomethyltransferase 0.09833 0.00627 0.10670 0.00600 0.00961 65 0.09249 0.00634 0.00826 93 0.01267 1.12160 140.261 0.26395 0.39772
Dihydrolipoyl dehydrogenase 0.09833 0.00627 0.10670 0.00600 0.00961 65 0.09249 0.00634 0.00826 93 0.01267 1.12160 140.261 0.26395 0.39772
Diaminopimelate decarboxylase 0.09827 0.00620 0.10291 0.00568 0.00935 65 0.09502 0.00637 0.00828 93 0.01249 0.63226 142.698 0.52823 0.63322
Homoserine dehydrogenase 0.09827 0.00620 0.10291 0.00568 0.00935 65 0.09502 0.00637 0.00828 93 0.01249 0.63226 142.698 0.52823 0.63322
Homoserine O-succinyltransferase 0.09827 0.00620 0.10291 0.00568 0.00935 65 0.09502 0.00637 0.00828 93 0.01249 0.63226 142.698 0.52823 0.63322
Acetate–CoA ligase 0.09750 0.00609 0.10362 0.00538 0.00910 65 0.09323 0.00622 0.00818 93 0.01223 0.85001 143.874 0.39673 0.51736
Aminodeoxychorismate lyase 0.09591 0.00638 0.10577 0.00623 0.00979 65 0.08901 0.00652 0.00838 93 0.01288 1.30117 139.883 0.19534 0.31602
Aminodeoxychorismate synthase 0.09591 0.00638 0.10577 0.00623 0.00979 65 0.08901 0.00652 0.00838 93 0.01288 1.30117 139.883 0.19534 0.31602
Cysteine synthase 0.09515 0.00611 0.09999 0.00545 0.00916 65 0.09177 0.00625 0.00820 93 0.01229 0.66803 143.527 0.50519 0.61472
Butyrate kinase 0.09396 0.00628 0.10575 0.00591 0.00953 65 0.08573 0.00635 0.00827 93 0.01262 1.58715 140.984 0.11472 0.22289
Phosphate butyryltransferase 0.09396 0.00628 0.10575 0.00591 0.00953 65 0.08573 0.00635 0.00827 93 0.01262 1.58715 140.984 0.11472 0.22289
Inositol-3-phosphate synthase 0.09150 0.00632 0.10232 0.00612 0.00971 65 0.08394 0.00636 0.00827 93 0.01275 1.44143 139.489 0.15170 0.26617
L-aspartate oxidase 0.09142 0.00610 0.09922 0.00575 0.00941 65 0.08597 0.00596 0.00801 93 0.01235 1.07297 139.423 0.28514 0.41481
Nicotinate-nucleotide diphosphorylase (carboxylating) 0.09142 0.00610 0.09922 0.00575 0.00941 65 0.08597 0.00596 0.00801 93 0.01235 1.07297 139.423 0.28514 0.41481
Quinolinate synthase 0.09142 0.00610 0.09922 0.00575 0.00941 65 0.08597 0.00596 0.00801 93 0.01235 1.07297 139.423 0.28514 0.41481
Superoxide reductase 0.09092 0.00608 0.10212 0.00566 0.00933 65 0.08309 0.00589 0.00796 93 0.01227 1.55169 139.564 0.12300 0.23196
Levanase 0.08973 0.00605 0.09653 0.00531 0.00904 65 0.08498 0.00611 0.00810 93 0.01214 0.95181 143.645 0.34279 0.45837
Formimidoyltetrahydrofolate cyclodeaminase 0.08849 0.00612 0.09491 0.00587 0.00950 65 0.08401 0.00596 0.00800 93 0.01242 0.87711 138.526 0.38195 0.50033
Glutamate formimidoyltransferase 0.08849 0.00612 0.09491 0.00587 0.00950 65 0.08401 0.00596 0.00800 93 0.01242 0.87711 138.526 0.38195 0.50033
Histidine ammonia-lyase 0.08849 0.00612 0.09491 0.00587 0.00950 65 0.08401 0.00596 0.00800 93 0.01242 0.87711 138.526 0.38195 0.50033
Imidazolonepropionase 0.08849 0.00612 0.09491 0.00587 0.00950 65 0.08401 0.00596 0.00800 93 0.01242 0.87711 138.526 0.38195 0.50033
Urocanate hydratase 0.08849 0.00612 0.09491 0.00587 0.00950 65 0.08401 0.00596 0.00800 93 0.01242 0.87711 138.526 0.38195 0.50033
Inorganic diphosphatase 0.08744 0.00591 0.09291 0.00506 0.00882 65 0.08361 0.00585 0.00793 93 0.01186 0.78341 143.856 0.43467 0.55481
Hyaluronoglucosaminidase 0.08632 0.00600 0.09204 0.00513 0.00889 65 0.08232 0.00611 0.00811 93 0.01203 0.80811 145.011 0.42035 0.54448
Methylenetetrahydrofolate reductase (NAD(P)H) 0.08596 0.00597 0.08841 0.00521 0.00896 65 0.08425 0.00596 0.00801 93 0.01201 0.34644 143.443 0.72952 0.78152
Alpha-glucosidase 0.08199 0.00608 0.08999 0.00542 0.00913 65 0.07640 0.00611 0.00810 93 0.01221 1.11305 142.859 0.26756 0.40019
D-lactate dehydrogenase 0.08190 0.00588 0.09152 0.00527 0.00901 65 0.07519 0.00555 0.00773 93 0.01187 1.37612 140.110 0.17098 0.28530
Methylmalonyl-CoA mutase 0.08118 0.00588 0.08414 0.00495 0.00873 65 0.07911 0.00586 0.00794 93 0.01180 0.42622 144.760 0.67058 0.75392
Beta-ketoacyl-[acyl-carrier-protein] synthase I 0.07733 0.00880 0.06687 0.00925 0.01193 65 0.08464 0.01429 0.01240 93 0.01720 -1.03307 152.846 0.30320 0.43662
Glucose-1-phosphatase 0.07571 0.00585 0.08319 0.00527 0.00901 65 0.07048 0.00549 0.00768 93 0.01184 1.07334 139.615 0.28497 0.41481
2-dehydropantoate 2-reductase 0.07218 0.00569 0.07556 0.00499 0.00877 65 0.06981 0.00525 0.00751 93 0.01154 0.49861 139.998 0.61884 0.71093
Carbonate dehydratase 0.06596 0.00561 0.06865 0.00496 0.00874 65 0.06407 0.00501 0.00734 93 0.01141 0.40107 138.293 0.68898 0.76864
Arylsulfatase 0.06462 0.00559 0.06788 0.00483 0.00862 65 0.06235 0.00506 0.00738 93 0.01135 0.48679 139.872 0.62717 0.71907
Phosphomethylpyrimidine synthase 0.05938 0.00550 0.06998 0.00512 0.00887 65 0.05197 0.00445 0.00692 93 0.01125 1.60063 131.674 0.11186 0.22225
Galactoside O-acetyltransferase 0.05510 0.00526 0.06505 0.00463 0.00844 65 0.04815 0.00413 0.00667 93 0.01075 1.57117 132.804 0.11852 0.22875
Glycerol kinase 0.05310 0.00498 0.06225 0.00411 0.00795 65 0.04670 0.00374 0.00634 93 0.01017 1.52977 133.689 0.12844 0.23533
All-trans-retinol 13,14-reductase 0.05270 0.00683 0.04689 0.00605 0.00965 65 0.05676 0.00832 0.00946 93 0.01351 -0.73034 149.855 0.46632 0.58442
Prephenate dehydratase 0.05052 0.00514 0.04612 0.00384 0.00769 65 0.05360 0.00442 0.00690 93 0.01033 -0.72481 143.699 0.46975 0.58744
Cobaltochelatase 0.04497 0.00516 0.04929 0.00450 0.00832 65 0.04195 0.00403 0.00659 93 0.01061 0.69191 132.991 0.49020 0.60133
Type II site-specific deoxyribonuclease 0.04472 0.00629 0.05129 0.00637 0.00990 65 0.04013 0.00620 0.00816 93 0.01283 0.87038 136.686 0.38562 0.50400
Acetolactate synthase 0.04408 0.00703 0.04225 0.00713 0.01047 65 0.04537 0.00838 0.00949 93 0.01413 -0.22088 144.503 0.82549 0.85964
Superoxide dismutase 0.04350 0.00483 0.04591 0.00397 0.00781 65 0.04181 0.00352 0.00616 93 0.00995 0.41288 132.559 0.68036 0.76048
2-dehydro-3-deoxygluconokinase 0.04288 0.00676 0.03962 0.00599 0.00960 65 0.04516 0.00816 0.00937 93 0.01341 -0.41288 149.582 0.68028 0.76048
Indole-3-glycerol-phosphate synthase 0.04260 0.00465 0.04464 0.00345 0.00729 65 0.04118 0.00341 0.00606 93 0.00948 0.36572 137.392 0.71513 0.78152
Methylaspartate mutase 0.04118 0.00689 0.04704 0.00790 0.01103 65 0.03708 0.00724 0.00883 93 0.01412 0.70494 134.018 0.48207 0.59261
UDP-galactopyranose mutase 0.03809 0.00462 0.04235 0.00384 0.00768 65 0.03510 0.00307 0.00575 93 0.00959 0.75562 127.810 0.45127 0.57174
6-carboxytetrahydropterin synthase 0.03772 0.00470 0.04123 0.00380 0.00765 65 0.03527 0.00329 0.00595 93 0.00969 0.61468 131.421 0.53983 0.64050
6-pyruvoyltetrahydropterin synthase 0.03772 0.00470 0.04123 0.00380 0.00765 65 0.03527 0.00329 0.00595 93 0.00969 0.61468 131.421 0.53983 0.64050
23S rRNA (adenine(2085)-N(6))-dimethyltransferase 0.03742 0.00450 0.04318 0.00342 0.00726 65 0.03340 0.00304 0.00572 93 0.00924 1.05920 132.564 0.29143 0.42185
Alkaline phosphatase 0.03500 0.00452 0.03879 0.00380 0.00765 65 0.03235 0.00286 0.00554 93 0.00944 0.68113 124.877 0.49705 0.60844
Dipeptidase E 0.03360 0.00442 0.03313 0.00306 0.00686 65 0.03393 0.00313 0.00580 93 0.00898 -0.08951 138.957 0.92880 0.93202
Threonine ammonia-lyase 0.03274 0.00433 0.03606 0.00342 0.00726 65 0.03041 0.00267 0.00536 93 0.00902 0.62655 126.594 0.53209 0.63648
Arabinogalactan endo-beta-1,4-galactanase 0.03134 0.00420 0.03242 0.00293 0.00671 65 0.03058 0.00272 0.00540 93 0.00862 0.21316 134.569 0.83153 0.86282
Alpha-N-acetylglucosaminidase 0.02891 0.00615 0.02313 0.00488 0.00866 65 0.03296 0.00675 0.00852 93 0.01215 -0.80902 150.060 0.41978 0.54448
Glycerophosphodiester phosphodiesterase 0.02857 0.00456 0.02949 0.00349 0.00733 65 0.02793 0.00318 0.00585 93 0.00938 0.16583 133.714 0.86854 0.89481
N-acetylmuramic acid 6-phosphate etherase 0.02767 0.00404 0.02489 0.00210 0.00568 65 0.02962 0.00293 0.00562 93 0.00799 -0.59243 150.337 0.55445 0.65650
Arabinan endo-1,5-alpha-L-arabinosidase 0.02741 0.00387 0.02544 0.00207 0.00565 65 0.02878 0.00259 0.00527 93 0.00773 -0.43190 146.695 0.66645 0.75392
Diaminopimelate epimerase 0.02700 0.00381 0.02787 0.00223 0.00586 65 0.02639 0.00237 0.00505 93 0.00773 0.19060 140.398 0.84912 0.87636
LL-diaminopimelate aminotransferase 0.02700 0.00381 0.02787 0.00223 0.00586 65 0.02639 0.00237 0.00505 93 0.00773 0.19060 140.398 0.84912 0.87636
Glucuronate isomerase 0.02549 0.00394 0.02137 0.00177 0.00521 65 0.02838 0.00293 0.00561 93 0.00766 -0.91523 154.205 0.36150 0.48117
Alpha-D-xyloside xylohydrolase 0.02548 0.00379 0.02273 0.00187 0.00536 65 0.02740 0.00257 0.00526 93 0.00751 -0.62073 149.868 0.53572 0.63823
Threonine synthase 0.02519 0.00377 0.02196 0.00179 0.00524 65 0.02744 0.00258 0.00526 93 0.00743 -0.73860 151.197 0.46130 0.58190
Adenosylcobalamin/alpha-ribazole phosphatase 0.02388 0.00356 0.02068 0.00148 0.00477 65 0.02611 0.00238 0.00506 93 0.00695 -0.78102 153.646 0.43599 0.55481
Adenosylcobinamide-GDP ribazoletransferase 0.02388 0.00356 0.02068 0.00148 0.00477 65 0.02611 0.00238 0.00506 93 0.00695 -0.78102 153.646 0.43599 0.55481
Adenosylcobinamide-phosphate guanylyltransferase 0.02388 0.00356 0.02068 0.00148 0.00477 65 0.02611 0.00238 0.00506 93 0.00695 -0.78102 153.646 0.43599 0.55481
Adenosylcobinamide kinase 0.02388 0.00356 0.02068 0.00148 0.00477 65 0.02611 0.00238 0.00506 93 0.00695 -0.78102 153.646 0.43599 0.55481
Nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase 0.02388 0.00356 0.02068 0.00148 0.00477 65 0.02611 0.00238 0.00506 93 0.00695 -0.78102 153.646 0.43599 0.55481
(4S)-4-hydroxy-2-oxoglutarate aldolase 0.02303 0.00370 0.02112 0.00178 0.00524 65 0.02436 0.00245 0.00513 93 0.00733 -0.44125 149.826 0.65967 0.75335
2-dehydro-3-deoxy-phosphogluconate aldolase 0.02303 0.00370 0.02112 0.00178 0.00524 65 0.02436 0.00245 0.00513 93 0.00733 -0.44125 149.826 0.65967 0.75335
4-O-beta-D-mannosyl-D-glucose phosphorylase 0.02223 0.00353 0.01764 0.00141 0.00466 65 0.02544 0.00235 0.00503 93 0.00685 -1.13757 154.315 0.25706 0.39066
Dihydroxy-acid dehydratase 0.02204 0.00352 0.02112 0.00178 0.00524 65 0.02268 0.00209 0.00475 93 0.00707 -0.22088 144.503 0.82549 0.85964
Ketol-acid reductoisomerase (NADP(+)) 0.02204 0.00352 0.02112 0.00178 0.00524 65 0.02268 0.00209 0.00475 93 0.00707 -0.22088 144.503 0.82549 0.85964
Gluconate 5-dehydrogenase 0.02203 0.00352 0.02117 0.00179 0.00525 65 0.02264 0.00209 0.00474 93 0.00707 -0.20778 144.246 0.83569 0.86559
Xylulokinase 0.02201 0.00351 0.02112 0.00178 0.00524 65 0.02264 0.00209 0.00474 93 0.00706 -0.21413 144.428 0.83074 0.86282
Alanine dehydrogenase 0.02190 0.00352 0.02066 0.00179 0.00524 65 0.02278 0.00209 0.00475 93 0.00707 -0.29945 144.413 0.76503 0.80245
Non-reducing end alpha-L-arabinofuranosidase 0.02141 0.00353 0.02120 0.00185 0.00533 65 0.02157 0.00207 0.00472 93 0.00712 -0.05203 142.617 0.95858 0.96024
Mannonate dehydratase 0.02109 0.00350 0.02042 0.00176 0.00521 65 0.02157 0.00207 0.00472 93 0.00703 -0.16304 144.482 0.87071 0.89546
Choline-phosphate cytidylyltransferase 0.02059 0.00344 0.02352 0.00198 0.00551 65 0.01854 0.00181 0.00441 93 0.00706 0.70494 134.018 0.48207 0.59261
Methylaspartate ammonia-lyase 0.02059 0.00344 0.02352 0.00198 0.00551 65 0.01854 0.00181 0.00441 93 0.00706 0.70494 134.018 0.48207 0.59261
Tryptophanase 0.02059 0.00344 0.02352 0.00198 0.00551 65 0.01854 0.00181 0.00441 93 0.00706 0.70494 134.018 0.48207 0.59261
Thymidylate synthase (FAD) 0.02007 0.00326 0.01881 0.00145 0.00472 65 0.02094 0.00186 0.00447 93 0.00650 -0.32792 147.729 0.74343 0.78693
L-arabinose isomerase 0.01894 0.00323 0.01780 0.00141 0.00466 65 0.01973 0.00183 0.00444 93 0.00643 -0.30075 148.045 0.76403 0.80245
L-ribulose-5-phosphate 4-epimerase 0.01894 0.00323 0.01780 0.00141 0.00466 65 0.01973 0.00183 0.00444 93 0.00643 -0.30075 148.045 0.76403 0.80245
Pectinesterase 0.01880 0.00326 0.01765 0.00148 0.00477 65 0.01961 0.00183 0.00443 93 0.00651 -0.30023 146.378 0.76443 0.80245
5-dehydro-4-deoxy-D-glucuronate isomerase 0.01848 0.00322 0.01688 0.00139 0.00462 65 0.01961 0.00183 0.00443 93 0.00640 -0.42642 148.552 0.67042 0.75392
Altronate dehydratase 0.01848 0.00322 0.01688 0.00139 0.00462 65 0.01961 0.00183 0.00443 93 0.00640 -0.42642 148.552 0.67042 0.75392
Tagaturonate reductase 0.01848 0.00322 0.01688 0.00139 0.00462 65 0.01961 0.00183 0.00443 93 0.00640 -0.42642 148.552 0.67042 0.75392
Chondroitin-sulfate-ABC endolyase 0.01817 0.00322 0.01610 0.00137 0.00460 65 0.01961 0.00183 0.00443 93 0.00639 -0.54890 148.868 0.58390 0.68024
Chondroitin-sulfate-ABC exolyase 0.01817 0.00322 0.01610 0.00137 0.00460 65 0.01961 0.00183 0.00443 93 0.00639 -0.54890 148.868 0.58390 0.68024
Fructuronate reductase 0.01817 0.00322 0.01610 0.00137 0.00460 65 0.01961 0.00183 0.00443 93 0.00639 -0.54890 148.868 0.58390 0.68024
Beta-fructofuranosidase 0.01721 0.00319 0.01456 0.00123 0.00435 65 0.01906 0.00187 0.00449 93 0.00625 -0.71857 152.532 0.47351 0.59072
CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase 0.01715 0.00341 0.01886 0.00198 0.00551 65 0.01595 0.00176 0.00435 93 0.00703 0.41410 132.799 0.67947 0.76048
Lysozyme 0.01644 0.00333 0.02180 0.00233 0.00598 65 0.01268 0.00134 0.00379 93 0.00708 1.28775 113.020 0.20046 0.32241
Leucyltransferase 0.01613 0.00335 0.01886 0.00198 0.00551 65 0.01423 0.00164 0.00421 93 0.00693 0.66794 129.605 0.50536 0.61472
Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) 0.01603 0.00334 0.01820 0.00196 0.00549 65 0.01451 0.00164 0.00420 93 0.00692 0.53299 129.906 0.59495 0.69033
Nitric-oxide reductase (cytochrome c) 0.01582 0.00335 0.01809 0.00197 0.00550 65 0.01423 0.00164 0.00421 93 0.00692 0.55712 129.852 0.57841 0.67931
Dextranase 0.01406 0.00282 0.01373 0.00122 0.00433 65 0.01429 0.00129 0.00373 93 0.00572 -0.09911 140.345 0.92119 0.92599
Phosphatidylglycerophosphatase 0.01400 0.00308 0.01802 0.00197 0.00551 65 0.01119 0.00117 0.00355 93 0.00656 1.04229 114.441 0.29947 0.43241
Beta-lactamase 0.01383 0.00293 0.01589 0.00139 0.00462 65 0.01239 0.00134 0.00380 93 0.00598 0.58609 136.401 0.55878 0.66028
L-rhamnose isomerase 0.01317 0.00301 0.01192 0.00124 0.00436 65 0.01405 0.00158 0.00412 93 0.00600 -0.35474 147.413 0.72329 0.78152
Rhamnulokinase 0.01317 0.00301 0.01192 0.00124 0.00436 65 0.01405 0.00158 0.00412 93 0.00600 -0.35474 147.413 0.72329 0.78152
Rhamnulose-1-phosphate aldolase 0.01317 0.00301 0.01192 0.00124 0.00436 65 0.01405 0.00158 0.00412 93 0.00600 -0.35474 147.413 0.72329 0.78152
Maltose alpha-D-glucosyltransferase 0.01300 0.00300 0.01245 0.00135 0.00456 65 0.01338 0.00149 0.00400 93 0.00606 -0.15297 141.979 0.87864 0.90201
UDP-glucuronate 4-epimerase 0.01268 0.00273 0.01408 0.00106 0.00404 65 0.01170 0.00127 0.00370 93 0.00548 0.43564 145.391 0.66375 0.75392
Glycerol-3-phosphate cytidylyltransferase 0.01267 0.00300 0.01725 0.00196 0.00550 65 0.00947 0.00104 0.00334 93 0.00643 1.21009 109.604 0.22885 0.35908
4-carboxymuconolactone decarboxylase 0.01208 0.00270 0.01416 0.00106 0.00405 65 0.01063 0.00122 0.00362 93 0.00543 0.64950 143.609 0.51705 0.62597
Cyclic pyranopterin phosphate synthase 0.01176 0.00269 0.01338 0.00105 0.00401 65 0.01063 0.00122 0.00362 93 0.00541 0.50921 144.268 0.61138 0.70376
Protein-L-isoaspartate(D-aspartate) O-methyltransferase 0.01176 0.00269 0.01338 0.00105 0.00401 65 0.01063 0.00122 0.00362 93 0.00541 0.50921 144.268 0.61138 0.70376
UDP-glucuronate decarboxylase 0.01176 0.00269 0.01338 0.00105 0.00401 65 0.01063 0.00122 0.00362 93 0.00541 0.50921 144.268 0.61138 0.70376
Alpha-glucuronidase 0.01102 0.00265 0.00930 0.00084 0.00360 65 0.01222 0.00131 0.00375 93 0.00520 -0.56115 153.036 0.57552 0.67729
5’ to 3’ exodeoxyribonuclease (nucleoside 3’-phosphate-forming) 0.01070 0.00264 0.00852 0.00082 0.00354 65 0.01222 0.00131 0.00375 93 0.00516 -0.71542 153.657 0.47544 0.59072
Formyltetrahydrofolate deformylase 0.01070 0.00264 0.00852 0.00082 0.00354 65 0.01222 0.00131 0.00375 93 0.00516 -0.71542 153.657 0.47544 0.59072
Lipoate–protein ligase 0.01056 0.00274 0.00720 0.00078 0.00346 65 0.01291 0.00147 0.00397 93 0.00527 -1.08388 155.709 0.28010 0.41477
(R)-2-methylmalate dehydratase 0.00684 0.00324 0.00820 0.00203 0.00559 65 0.00590 0.00142 0.00391 93 0.00682 0.33663 121.543 0.73697 0.78152
3-isopropylmalate dehydratase 0.00684 0.00324 0.00820 0.00203 0.00559 65 0.00590 0.00142 0.00391 93 0.00682 0.33663 121.543 0.73697 0.78152
Lactoylglutathione lyase 0.00647 0.00219 0.00387 0.00033 0.00225 65 0.00829 0.00105 0.00336 93 0.00405 -1.08932 149.749 0.27776 0.41237
Sulfate adenylyltransferase 0.00623 0.00290 0.00586 0.00121 0.00432 65 0.00649 0.00143 0.00391 93 0.00583 -0.10880 144.556 0.91351 0.91987
L-threonine aldolase 0.00545 0.00176 0.00700 0.00062 0.00310 65 0.00436 0.00040 0.00208 93 0.00373 0.70639 117.912 0.48134 0.59261
Gingipain R 0.00539 0.00208 0.00781 0.00107 0.00405 65 0.00370 0.00042 0.00212 93 0.00457 0.89934 98.630 0.37066 0.49111
L-rhamnose mutarotase 0.00527 0.00208 0.00555 0.00073 0.00336 65 0.00508 0.00066 0.00266 93 0.00428 0.11022 132.912 0.91240 0.91987
Aconitate hydratase 0.00356 0.00185 0.00590 0.00087 0.00366 65 0.00191 0.00031 0.00183 93 0.00410 0.97374 95.817 0.33264 0.44583
Isocitrate dehydrogenase (NADP(+)) 0.00356 0.00185 0.00590 0.00087 0.00366 65 0.00191 0.00031 0.00183 93 0.00410 0.97374 95.817 0.33264 0.44583
Polar-amino-acid-transporting ATPase 0.00347 0.00166 0.00161 0.00007 0.00104 65 0.00476 0.00069 0.00273 93 0.00292 -1.07874 117.046 0.28292 0.41481
(R)-citramalate synthase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
2-isopropylmalate synthase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
3-isopropylmalate dehydrogenase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
Acetylglutamate kinase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
Acetylornithine deacetylase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
Acetylornithine transaminase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
Argininosuccinate lyase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
Argininosuccinate synthase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
ATP phosphoribosyltransferase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
Histidinol-phosphatase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
Histidinol dehydrogenase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
Imidazoleglycerol-phosphate dehydratase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
isomerase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
N-acetyl-gamma-glutamyl-phosphate reductase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
N-succinylornithine carbamoyltransferase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
Phosphoribosyl-AMP cyclohydrolase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
Phosphoribosyl-ATP diphosphatase 0.00342 0.00162 0.00410 0.00051 0.00280 65 0.00295 0.00035 0.00195 93 0.00341 0.33663 121.543 0.73697 0.78152
Anthranilate phosphoribosyltransferase 0.00339 0.00162 0.00410 0.00051 0.00280 65 0.00290 0.00036 0.00195 93 0.00341 0.35080 121.551 0.72634 0.78152
Potassium-transporting ATPase 0.00316 0.00310 0.00752 0.00368 0.00752 65 0.00010 0.00000 0.00010 93 0.00752 0.98624 64.024 0.32773 0.44129
Creatininase 0.00315 0.00164 0.00084 0.00003 0.00071 65 0.00476 0.00069 0.00273 93 0.00282 -1.39249 104.041 0.16674 0.28014
Exo-1,4-beta-D-glucosaminidase 0.00315 0.00164 0.00084 0.00003 0.00071 65 0.00476 0.00069 0.00273 93 0.00282 -1.39249 104.041 0.16674 0.28014
N-acetylneuraminate synthase 0.00315 0.00164 0.00084 0.00003 0.00071 65 0.00476 0.00069 0.00273 93 0.00282 -1.39249 104.041 0.16674 0.28014
N-acylneuraminate cytidylyltransferase 0.00315 0.00164 0.00084 0.00003 0.00071 65 0.00476 0.00069 0.00273 93 0.00282 -1.39249 104.041 0.16674 0.28014
RNA ligase (ATP) 0.00315 0.00164 0.00084 0.00003 0.00071 65 0.00476 0.00069 0.00273 93 0.00282 -1.39249 104.041 0.16674 0.28014
4-phosphoerythronate dehydrogenase 0.00311 0.00145 0.00293 0.00030 0.00216 65 0.00324 0.00036 0.00196 93 0.00291 -0.10880 144.556 0.91351 0.91987
8-amino-7-oxononanoate synthase 0.00311 0.00145 0.00293 0.00030 0.00216 65 0.00324 0.00036 0.00196 93 0.00291 -0.10880 144.556 0.91351 0.91987
Adenylyl-sulfate kinase 0.00311 0.00145 0.00293 0.00030 0.00216 65 0.00324 0.00036 0.00196 93 0.00291 -0.10880 144.556 0.91351 0.91987
AMP nucleosidase 0.00311 0.00145 0.00293 0.00030 0.00216 65 0.00324 0.00036 0.00196 93 0.00291 -0.10880 144.556 0.91351 0.91987
Exodeoxyribonuclease V 0.00311 0.00145 0.00293 0.00030 0.00216 65 0.00324 0.00036 0.00196 93 0.00291 -0.10880 144.556 0.91351 0.91987
Nucleoside-diphosphate kinase 0.00311 0.00145 0.00293 0.00030 0.00216 65 0.00324 0.00036 0.00196 93 0.00291 -0.10880 144.556 0.91351 0.91987
Polynucleotide adenylyltransferase 0.00311 0.00145 0.00293 0.00030 0.00216 65 0.00324 0.00036 0.00196 93 0.00291 -0.10880 144.556 0.91351 0.91987
Pyridoxine 5’-phosphate synthase 0.00311 0.00145 0.00293 0.00030 0.00216 65 0.00324 0.00036 0.00196 93 0.00291 -0.10880 144.556 0.91351 0.91987
Xylose isomerase 0.00307 0.00159 0.00332 0.00047 0.00270 65 0.00290 0.00036 0.00195 93 0.00333 0.12651 124.682 0.89953 0.91987
CDP-glycerol glycerophosphotransferase 0.00230 0.00133 0.00393 0.00050 0.00276 65 0.00116 0.00013 0.00116 93 0.00300 0.92313 86.745 0.35850 0.47828
Hippurate hydrolase 0.00207 0.00126 0.00251 0.00041 0.00251 65 0.00176 0.00014 0.00125 93 0.00280 0.26828 95.453 0.78906 0.82616
Pyrroline-5-carboxylate reductase 0.00171 0.00071 0.00244 0.00012 0.00137 65 0.00120 0.00005 0.00073 93 0.00155 0.80158 99.840 0.42470 0.54767
Alpha-L-rhamnosidase 0.00158 0.00065 0.00193 0.00009 0.00116 65 0.00134 0.00005 0.00075 93 0.00138 0.43390 114.502 0.66517 0.75392
Nitrous-oxide reductase 0.00158 0.00065 0.00193 0.00009 0.00116 65 0.00134 0.00005 0.00075 93 0.00138 0.43390 114.502 0.66517 0.75392
Type III site-specific deoxyribonuclease 0.00133 0.00080 0.00078 0.00004 0.00078 65 0.00172 0.00014 0.00125 93 0.00147 -0.64553 145.619 0.51960 0.62676
Cellobiose phosphorylase 0.00124 0.00060 0.00148 0.00007 0.00104 65 0.00107 0.00005 0.00071 93 0.00126 0.32436 119.723 0.74623 0.78844
Citrate CoA-transferase 0.00105 0.00103 0.00251 0.00041 0.00251 65 0.00003 0.00000 0.00003 93 0.00251 0.98624 64.024 0.32773 0.44129
Citrate lyase holo-[acyl-carrier protein] synthase 0.00105 0.00103 0.00251 0.00041 0.00251 65 0.00003 0.00000 0.00003 93 0.00251 0.98624 64.024 0.32773 0.44129
Citryl-CoA lyase 0.00105 0.00103 0.00251 0.00041 0.00251 65 0.00003 0.00000 0.00003 93 0.00251 0.98624 64.024 0.32773 0.44129
RNA-directed DNA polymerase 0.00105 0.00103 0.00251 0.00041 0.00251 65 0.00003 0.00000 0.00003 93 0.00251 0.98624 64.024 0.32773 0.44129
Glucosylceramidase 0.00092 0.00051 0.00070 0.00003 0.00070 65 0.00107 0.00005 0.00071 93 0.00100 -0.36761 151.566 0.71368 0.78152
2-iminoacetate synthase 0.00032 0.00032 0.00078 0.00004 0.00078 65 0.00000 0.00000 0.00000 93 0.00078 1.00000 64.000 0.32108 0.43845
Asparagine synthase (glutamine-hydrolyzing) 0.00032 0.00032 0.00078 0.00004 0.00078 65 0.00000 0.00000 0.00000 93 0.00078 1.00000 64.000 0.32108 0.43845
Aspartyl aminopeptidase 0.00032 0.00032 0.00078 0.00004 0.00078 65 0.00000 0.00000 0.00000 93 0.00078 1.00000 64.000 0.32108 0.43845
Cellulase 0.00032 0.00032 0.00078 0.00004 0.00078 65 0.00000 0.00000 0.00000 93 0.00078 1.00000 64.000 0.32108 0.43845
Citrate (Si)-synthase 0.00032 0.00032 0.00078 0.00004 0.00078 65 0.00000 0.00000 0.00000 93 0.00078 1.00000 64.000 0.32108 0.43845
D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase 0.00032 0.00032 0.00078 0.00004 0.00078 65 0.00000 0.00000 0.00000 93 0.00078 1.00000 64.000 0.32108 0.43845
D-glycero-alpha-D-manno-heptose-7-phosphate kinase 0.00032 0.00032 0.00078 0.00004 0.00078 65 0.00000 0.00000 0.00000 93 0.00078 1.00000 64.000 0.32108 0.43845
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase 0.00032 0.00032 0.00078 0.00004 0.00078 65 0.00000 0.00000 0.00000 93 0.00078 1.00000 64.000 0.32108 0.43845
D-sedoheptulose 7-phosphate isomerase 0.00032 0.00032 0.00078 0.00004 0.00078 65 0.00000 0.00000 0.00000 93 0.00078 1.00000 64.000 0.32108 0.43845
Endo-1,4-beta-xylanase 0.00032 0.00032 0.00078 0.00004 0.00078 65 0.00000 0.00000 0.00000 93 0.00078 1.00000 64.000 0.32108 0.43845
Glutamate-5-semialdehyde dehydrogenase 0.00032 0.00032 0.00078 0.00004 0.00078 65 0.00000 0.00000 0.00000 93 0.00078 1.00000 64.000 0.32108 0.43845
Glutamate 5-kinase 0.00032 0.00032 0.00078 0.00004 0.00078 65 0.00000 0.00000 0.00000 93 0.00078 1.00000 64.000 0.32108 0.43845
Phosphoadenylyl-sulfate reductase (thioredoxin) 0.00032 0.00032 0.00078 0.00004 0.00078 65 0.00000 0.00000 0.00000 93 0.00078 1.00000 64.000 0.32108 0.43845
Prolyl aminopeptidase 0.00032 0.00032 0.00078 0.00004 0.00078 65 0.00000 0.00000 0.00000 93 0.00078 1.00000 64.000 0.32108 0.43845
Thiazole synthase 0.00032 0.00032 0.00078 0.00004 0.00078 65 0.00000 0.00000 0.00000 93 0.00078 1.00000 64.000 0.32108 0.43845 
plot.dat <- tb.ra %>%
  arrange(desc(`Overall Mean`)) %>%
  slice_head(n=50) %>%
  mutate(
    description = fct_reorder(description, `Overall Mean`),
    description = factor(description, levels = levels(description), ordered=T)
  ) %>%
  arrange(description) %>%
  mutate(
    id = 1:n(),
    step = ifelse(id%%2 == 0, 1, 0),
    Mean_diff = `Tumor Mean` - `Non-Tumor Mean`,
    diff_se = SEpooled,
    Mean_diff_ll = Mean_diff - qt(0.975, df)*diff_se,
    Mean_diff_ul = Mean_diff + qt(0.975, df)*diff_se
  ) %>%
  pivot_longer(
    cols=contains("Mean"),
    names_to = "group",
    values_to = "mean"
  )



p1.d <- plot.dat %>%
  filter(group %in% c("Tumor Mean","Non-Tumor Mean")) %>%
  mutate(
    group = ifelse(group == "Tumor Mean", "Tumor", "Non-Tumor"),
    col = ifelse(step == 1, "grey90", "white"),
    h=1, w=Inf
    
  )
p1 <- ggplot()+
  geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_bar(data=p1.d,
             aes(x=mean, y=description,
                 group=group, color=group,
                 fill=group),
             stat="identity",position = "dodge",
             alpha = 1)+
    labs(x="Mean RelAbundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      plot.margin = unit(c(1,0,1,1), "lines")
    )

p2.d <- plot.dat %>%
  filter(group %in% c("Mean_diff", "Mean_diff_ll", "Mean_diff_ul")) %>%
  pivot_wider(
    names_from = group,
    values_from = mean
  ) %>%
  mutate(
    group = ifelse(Mean_diff > 0, "Tumor", "Non-Tumor"),
    p = sprintf("%.3f", round(p,3)),
    ll = min(Mean_diff_ll)-0.01,
    ul = max(Mean_diff_ul)+0.01
  )
p2<-ggplot(p2.d, aes(x=Mean_diff, y=description))+
    geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_vline(xintercept = 0, linetype="dashed", alpha=0.5)+
    geom_segment(aes(x=Mean_diff_ll, y=description, xend=Mean_diff_ul, yend=description))+
    geom_point(aes(fill=group, color=group))+
    geom_text(aes(label=p, x=unique(ul)+0.1))+
    coord_cartesian(xlim = c(unique(p2.d$ll), unique(p2.d$ul)),
                    clip = 'off') +
    annotate("text", x=unique(p2.d$ul)+0.2,y = 25,
             angle=90,
             label="p-value (uncorrected)")+
    labs(x="Mean Difference in RelAbundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      axis.title.y = element_blank(),
      axis.text.y = element_blank(),
      axis.line.y = element_blank(),
      axis.ticks.y = element_blank(),
      plot.margin = unit(c(1,4,1,0), "lines")
    )

# plot
p1 + p2 +
  plot_annotation(title="Stratefied EC Data - Prevotella spp. (genus level only): 50 most abundant descriptions")

Modeling Difference between Tumor and Non-Tumor

For the modeling, we used a generalized linear mixed model (GLMM).

First, we looked at the biserial correlation between the abundance of each description and the tumor status.

tb <- mydata %>%
  group_by(description)%>%
  summarise(
    r = cor(tumor, Abundance)
  ) %>%
  mutate(
    M=mean(r)
  )

ggplot(tb, aes(x=r))+
  geom_density()+
  geom_vline(aes(xintercept = M))+
  labs(x="Biserial Correlation",title="Relationship between description abundance and tumor (tumor vs. non-tumor)")+
  theme(panel.grid = element_blank())

Next, we need the data to be on an interpretable scale. First, let’s use the raw abundance like scale.

p <- ggplot(mydata, aes(x=Abundance))+
  geom_density()
p

mydata <- mydata %>%
  mutate(Abundance.dich=ifelse(Abundance==0, 0, 1))
table(mydata$Abundance.dich)

    0     1 
38726 52756

Let’s first run models by description so that we can avoid the nesting issue initially. We will come back to this to conduct the final model (it will be more powerful).

DESCRIPTIONS <- unique(mydata$description)
i<-1
dat0 <- mydata %>% filter(description==DESCRIPTIONS[i])

# quasipossion (approximately negative binom) give an approx. answer.
fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
summary(fit0)

Call:
glm(formula = Abundance ~ 1 + tumor, family = quasipoisson(link = "log"), 
    data = dat0)

Deviance Residuals: 
   Min      1Q  Median      3Q     Max  
 -7.50   -6.68   -4.88    1.25   29.69  

Coefficients:
            Estimate Std. Error t value Pr(>|t|)    
(Intercept)    3.336      0.177   18.85   <2e-16 ***
tumor         -0.230      0.296   -0.78     0.44    
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for quasipoisson family taken to be 81.936)

    Null deviance: 8507.2  on 157  degrees of freedom
Residual deviance: 8456.6  on 156  degrees of freedom
AIC: NA

Number of Fisher Scoring iterations: 6

Run over all descriptors

results.out <- as.data.frame(matrix(ncol=4, nrow=length(DESCRIPTIONS)))
colnames(results.out) <- c("description", "Est", "SE", "p")
#results.out$description <-DESCRIPTIONS

i <- 1
for(i in 1:length(DESCRIPTIONS)){
#for(i in 1:5){ 
  dat0 <- mydata %>%
    filter(description == DESCRIPTIONS[i])
  fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
  fit.sum <- summary(fit0)
  results.out[i, 1] <- DESCRIPTIONS[i]
  results.out[i, 2:4] <- fit.sum$coefficients[2, c(1,2,4)]
}

results.out$fdr_p <- p.adjust(results.out$p, method="fdr")

kable(results.out, format="html", digits=3) %>%
  kable_styling(full_width = T)%>%
  scroll_box(width="100%", height="600px")
description Est SE p fdr_p
(2E,6E)-farnesyl diphosphate synthase -0.230 0.296 0.438 0.635
(4S)-4-hydroxy-2-oxoglutarate aldolase -0.628 0.582 0.282 0.635
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin) -0.230 0.296 0.438 0.635
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin) -0.230 0.296 0.438 0.635
(Kdo)-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -0.230 0.296 0.438 0.635
(Kdo)(2)-lipid IV(A) (2-8) 3-deoxy-D-manno-octulosonic acid transferase -0.230 0.296 0.438 0.635
(Kdo)(3)-lipid IV(A) (2-4) 3-deoxy-D-manno-octulosonic acid transferase -0.230 0.296 0.438 0.635
(R)-2-methylmalate dehydratase -0.100 1.127 0.930 0.968
(R)-citramalate synthase -0.100 1.127 0.930 0.968
[Acyl-carrier-protein] S-malonyltransferase -0.230 0.296 0.438 0.635
[Formate-C-acetyltransferase]-activating enzyme -0.204 0.299 0.496 0.635
[Ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase -0.230 0.296 0.438 0.635
1-acylglycerol-3-phosphate O-acyltransferase -0.230 0.296 0.438 0.635
1-deoxy-D-xylulose-5-phosphate reductoisomerase -0.230 0.296 0.438 0.635
1-deoxy-D-xylulose-5-phosphate synthase -0.211 0.305 0.489 0.635
1,4-alpha-glucan branching enzyme -0.230 0.296 0.438 0.635
1,4-beta-mannosyl-N-acetylglucosamine phosphorylase -0.234 0.288 0.419 0.635
1,4-dihydroxy-2-naphthoate polyprenyltransferase -0.230 0.296 0.438 0.635
1,4-dihydroxy-2-naphthoyl-CoA synthase -0.230 0.296 0.438 0.635
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase -0.230 0.296 0.438 0.635
16S rRNA (cytidine(1402)-2’-O)-methyltransferase -0.242 0.294 0.412 0.635
16S rRNA (cytosine(1402)-N(4))-methyltransferase -0.230 0.296 0.438 0.635
16S rRNA (guanine(527)-N(7))-methyltransferase -0.230 0.296 0.438 0.635
16S rRNA (uracil(1498)-N(3))-methyltransferase -0.230 0.296 0.438 0.635
2’,3’-cyclic-nucleotide 2’-phosphodiesterase -0.285 0.310 0.360 0.635
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase -0.240 0.304 0.431 0.635
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -0.230 0.296 0.438 0.635
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -0.232 0.307 0.452 0.635
2-dehydro-3-deoxy-phosphogluconate aldolase -0.628 0.582 0.282 0.635
2-dehydro-3-deoxygluconokinase -0.577 0.590 0.329 0.635
2-dehydropantoate 2-reductase -0.220 0.329 0.504 0.635
2-iminoacetate synthase 18.519 3411.091 0.996 0.997
2-iminobutanoate/2-iminopropanoate deaminase -0.230 0.296 0.438 0.635
2-isopropylmalate synthase -0.100 1.127 0.930 0.968
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase -0.230 0.296 0.438 0.635
2-oxoacid oxidoreductase (ferredoxin) -0.241 0.306 0.433 0.635
2-oxoglutarate synthase -0.237 0.303 0.434 0.635
23S rRNA (adenine(2085)-N(6))-dimethyltransferase 0.141 0.367 0.701 0.790
23S rRNA (adenine(2503)-C(2))-methyltransferase -0.230 0.296 0.438 0.635
23S rRNA (cytosine(1962)-C(5))-methyltransferase -0.230 0.296 0.438 0.635
23S rRNA (pseudouridine(1915)-N(3))-methyltransferase -0.230 0.296 0.438 0.635
23S rRNA (uracil(1939)-C(5))-methyltransferase -0.230 0.296 0.438 0.635
23S rRNA pseudouridine(1911/1915/1917) synthase -0.230 0.296 0.438 0.635
23S rRNA pseudouridine(2605) synthase -0.230 0.296 0.438 0.635
23S rRNA pseudouridine(746) synthase -0.223 0.336 0.508 0.635
3’-nucleotidase -0.285 0.310 0.360 0.635
3’(2’),5’-bisphosphate nucleotidase -0.242 0.294 0.412 0.635
3-dehydroquinate dehydratase -0.230 0.296 0.438 0.635
3-dehydroquinate synthase -0.230 0.296 0.438 0.635
3-deoxy-8-phosphooctulonate synthase -0.230 0.296 0.438 0.635
3-deoxy-manno-octulosonate-8-phosphatase -0.232 0.301 0.441 0.635
3-deoxy-manno-octulosonate cytidylyltransferase -0.243 0.292 0.407 0.635
3-hydroxyacyl-[acyl-carrier-protein] dehydratase -0.331 0.309 0.285 0.635
3-isopropylmalate dehydratase -0.100 1.127 0.930 0.968
3-isopropylmalate dehydrogenase -0.100 1.127 0.930 0.968
3-methyl-2-oxobutanoate hydroxymethyltransferase -0.213 0.298 0.477 0.635
3-oxoacyl-[acyl-carrier-protein] reductase -0.342 0.306 0.265 0.635
3-phosphoshikimate 1-carboxyvinyltransferase -0.230 0.296 0.438 0.635
3,4-dihydroxy-2-butanone-4-phosphate synthase -0.226 0.295 0.445 0.635
4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol kinase -0.230 0.296 0.438 0.635
4-alpha-glucanotransferase -0.230 0.296 0.438 0.635
4-carboxymuconolactone decarboxylase -0.135 0.612 0.825 0.905
4-hydroxy-3-methylbut-2-enyl diphosphate reductase -0.230 0.296 0.438 0.635
4-hydroxy-tetrahydrodipicolinate reductase -0.230 0.296 0.438 0.635
4-hydroxy-tetrahydrodipicolinate synthase -0.230 0.296 0.438 0.635
4-hydroxythreonine-4-phosphate dehydrogenase -0.230 0.296 0.438 0.635
4-O-beta-D-mannosyl-D-glucose phosphorylase -0.588 0.587 0.318 0.635
4-phosphoerythronate dehydrogenase -0.754 1.120 0.502 0.635
5’-nucleotidase -0.225 0.298 0.452 0.635
5’ to 3’ exodeoxyribonuclease (nucleoside 3’-phosphate-forming) -0.789 0.881 0.372 0.635
5-(carboxyamino)imidazole ribonucleotide mutase -0.230 0.296 0.438 0.635
5-amino-6-(5-phosphoribosylamino)uracil reductase -0.230 0.296 0.438 0.635
5-dehydro-4-deoxy-D-glucuronate isomerase -0.676 0.652 0.302 0.635
5-formyltetrahydrofolate cyclo-ligase -0.230 0.296 0.438 0.635
6-carboxytetrahydropterin synthase -0.395 0.451 0.383 0.635
6-phosphofructokinase -0.230 0.296 0.438 0.635
6-pyruvoyltetrahydropterin synthase -0.395 0.451 0.383 0.635
6,7-dimethyl-8-ribityllumazine synthase -0.230 0.296 0.438 0.635
7-cyano-7-deazaguanine synthase -0.230 0.296 0.438 0.635
8-amino-7-oxononanoate synthase -0.754 1.120 0.502 0.635
8-oxo-dGTP diphosphatase -0.128 0.324 0.693 0.790
Acetate–CoA ligase -0.203 0.301 0.500 0.635
Acetate kinase -0.230 0.296 0.438 0.635
Acetolactate synthase -0.548 0.584 0.350 0.635
acetylglucosaminyltransferase -0.230 0.296 0.438 0.635
Acetylglutamate kinase -0.100 1.127 0.930 0.968
Acetylornithine deacetylase -0.100 1.127 0.930 0.968
Acetylornithine transaminase -0.100 1.127 0.930 0.968
Acid phosphatase -0.073 0.305 0.811 0.902
Aconitate hydratase -0.429 1.387 0.758 0.845
Acyl-[acyl-carrier-protein]–UDP-N-acetylglucosamine O-acyltransferase -0.230 0.296 0.438 0.635
Adenine phosphoribosyltransferase -0.230 0.296 0.438 0.635
Adenosylcobalamin/alpha-ribazole phosphatase -0.680 0.538 0.208 0.635
Adenosylcobinamide-GDP ribazoletransferase -0.680 0.538 0.208 0.635
Adenosylcobinamide-phosphate guanylyltransferase -0.680 0.538 0.208 0.635
Adenosylcobinamide kinase -0.680 0.538 0.208 0.635
Adenosylhomocysteine nucleosidase -0.230 0.296 0.438 0.635
Adenylate kinase -0.230 0.296 0.438 0.635
Adenylosuccinate lyase -0.230 0.296 0.438 0.635
Adenylosuccinate synthase -0.230 0.296 0.438 0.635
Adenylyl-sulfate kinase -0.754 1.120 0.502 0.635
Alanine–tRNA ligase -0.230 0.296 0.438 0.635
Alanine dehydrogenase -0.647 0.554 0.244 0.635
Alanine racemase -0.230 0.296 0.438 0.635
Aldose 1-epimerase -0.243 0.306 0.429 0.635
Alkaline phosphatase -0.400 0.466 0.392 0.635
All-trans-octaprenyl-diphosphate synthase -0.230 0.296 0.438 0.635
All-trans-retinol 13,14-reductase -0.696 0.523 0.185 0.635
Alpha-amylase -0.248 0.296 0.404 0.635
Alpha-D-xyloside xylohydrolase -0.603 0.561 0.284 0.635
Alpha-galactosidase -0.168 0.287 0.561 0.685
Alpha-glucosidase -0.117 0.305 0.702 0.790
Alpha-glucuronidase -0.788 0.881 0.373 0.635
Alpha-L-fucosidase -0.244 0.296 0.412 0.635
Alpha-L-rhamnosidase -0.319 0.983 0.746 0.837
Alpha-N-acetylglucosaminidase -0.855 0.801 0.287 0.635
Altronate dehydratase -0.676 0.652 0.302 0.635
Amidophosphoribosyltransferase -0.219 0.308 0.477 0.635
Aminoacyl-tRNA hydrolase -0.230 0.296 0.438 0.635
Aminodeoxychorismate lyase -0.158 0.328 0.632 0.736
Aminodeoxychorismate synthase -0.158 0.328 0.632 0.736
Aminomethyltransferase -0.190 0.321 0.556 0.680
AMP nucleosidase -0.754 1.120 0.502 0.635
Anthranilate phosphoribosyltransferase -0.089 1.133 0.938 0.969
Anthranilate synthase -0.163 0.338 0.630 0.736
Arabinan endo-1,5-alpha-L-arabinosidase -0.573 0.507 0.260 0.635
Arabinogalactan endo-beta-1,4-galactanase -0.483 0.529 0.363 0.635
Arabinose-5-phosphate isomerase -0.230 0.296 0.438 0.635
Arginine–tRNA ligase -0.230 0.296 0.438 0.635
Arginine decarboxylase -0.230 0.296 0.438 0.635
Argininosuccinate lyase -0.100 1.127 0.930 0.968
Argininosuccinate synthase -0.100 1.127 0.930 0.968
Arylsulfatase -0.131 0.339 0.701 0.790
Asparaginase -0.260 0.336 0.441 0.635
Asparagine–tRNA ligase -0.230 0.296 0.438 0.635
Asparagine synthase (glutamine-hydrolyzing) 18.519 3411.091 0.996 0.997
Aspartate–ammonia ligase -0.213 0.293 0.468 0.635
Aspartate–tRNA ligase -0.230 0.296 0.438 0.635
Aspartate-semialdehyde dehydrogenase -0.230 0.296 0.438 0.635
Aspartate 1-decarboxylase -0.213 0.298 0.477 0.635
Aspartate ammonia-lyase -0.259 0.322 0.423 0.635
Aspartate carbamoyltransferase -0.230 0.296 0.438 0.635
Aspartate kinase -0.249 0.296 0.402 0.635
Aspartate transaminase -0.235 0.289 0.416 0.635
Aspartyl aminopeptidase 18.519 3411.091 0.996 0.997
ATP phosphoribosyltransferase -0.100 1.127 0.930 0.968
Bacterial non-heme ferritin -0.219 0.301 0.468 0.635
Beta-1,4-mannooligosaccharide phosphorylase -0.234 0.288 0.419 0.635
Beta-fructofuranosidase -0.496 0.487 0.311 0.635
Beta-galactosidase -0.246 0.296 0.408 0.635
Beta-glucosidase -0.399 0.427 0.352 0.635
Beta-ketoacyl-[acyl-carrier-protein] synthase I -0.741 0.488 0.131 0.635
Beta-ketoacyl-[acyl-carrier-protein] synthase II -0.230 0.296 0.438 0.635
Beta-ketoacyl-[acyl-carrier-protein] synthase III -0.223 0.335 0.506 0.635
Beta-lactamase -0.298 0.574 0.604 0.718
Beta-N-acetylhexosaminidase -0.212 0.270 0.432 0.635
Biotin–[acetyl-CoA-carboxylase] ligase -0.230 0.296 0.438 0.635
Bleomycin hydrolase -0.224 0.296 0.452 0.635
Branched-chain-amino-acid transaminase -0.230 0.296 0.438 0.635
Butyrate kinase -0.147 0.329 0.655 0.755
C-terminal processing peptidase -0.230 0.296 0.438 0.635
Cadmium-exporting ATPase -0.201 0.284 0.481 0.635
Calcium-transporting ATPase -0.156 0.300 0.605 0.718
Carbamoyl-phosphate synthase (glutamine-hydrolyzing) -0.232 0.298 0.439 0.635
Carbonate dehydratase -0.169 0.333 0.614 0.727
Carboxynorspermidine decarboxylase -0.230 0.296 0.438 0.635
CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase -0.227 0.517 0.662 0.761
CDP-diacylglycerol–serine O-phosphatidyltransferase -0.230 0.296 0.438 0.635
CDP-glycerol glycerophosphotransferase 0.092 1.404 0.948 0.979
Cellobiose phosphorylase 0.154 1.349 0.909 0.968
Cellulase 18.519 3411.091 0.996 0.997
Choline-phosphate cytidylyltransferase -0.221 0.572 0.699 0.790
Chondroitin-sulfate-ABC endolyase -0.677 0.652 0.301 0.635
Chondroitin-sulfate-ABC exolyase -0.677 0.652 0.301 0.635
Chorismate mutase -0.230 0.296 0.438 0.635
Chorismate synthase -0.230 0.296 0.438 0.635
Citrate (Si)-synthase 18.519 3411.091 0.996 0.997
Citrate CoA-transferase 2.304 1.989 0.248 0.635
Citrate lyase holo-[acyl-carrier protein] synthase 2.304 1.989 0.248 0.635
Citryl-CoA lyase 2.304 1.989 0.248 0.635
Cob(I)yrinic acid a,c-diamide adenosyltransferase -0.256 0.335 0.446 0.635
Cobaltochelatase -0.341 0.419 0.416 0.635
Coproporphyrinogen dehydrogenase -0.227 0.294 0.441 0.635
Creatininase -2.232 1.933 0.250 0.635
Crossover junction endodeoxyribonuclease -0.230 0.296 0.438 0.635
CTP synthase (glutamine hydrolyzing) -0.230 0.296 0.438 0.635
Cu(2+)-exporting ATPase -0.224 0.285 0.434 0.635
Cyclic pyranopterin phosphate synthase -0.137 0.613 0.823 0.905
Cystathionine beta-lyase -0.267 0.319 0.403 0.635
Cysteine–tRNA ligase -0.230 0.296 0.438 0.635
Cysteine desulfurase -0.230 0.296 0.438 0.635
Cysteine synthase -0.260 0.313 0.407 0.635
Cytidine deaminase -0.230 0.296 0.438 0.635
D-Ala-D-Ala dipeptidase -0.199 0.288 0.490 0.635
D-alanine–D-alanine ligase -0.230 0.296 0.438 0.635
D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase 18.519 3411.091 0.996 0.997
D-glycero-alpha-D-manno-heptose-7-phosphate kinase 18.519 3411.091 0.996 0.997
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase 18.519 3411.091 0.996 0.997
D-lactate dehydrogenase -0.088 0.288 0.760 0.846
D-sedoheptulose 7-phosphate isomerase 18.519 3411.091 0.996 0.997
dCMP deaminase -0.230 0.296 0.438 0.635
Demethylmenaquinone methyltransferase -0.230 0.296 0.438 0.635
Deoxyribose-phosphate aldolase -0.230 0.296 0.438 0.635
Dephospho-CoA kinase -0.228 0.308 0.459 0.635
Dextranase -0.282 0.509 0.580 0.704
dGTPase -0.230 0.296 0.438 0.635
Diamine N-acetyltransferase -0.230 0.296 0.438 0.635
Diaminohydroxyphosphoribosylaminopyrimidine deaminase -0.230 0.296 0.438 0.635
Diaminopimelate decarboxylase -0.274 0.307 0.374 0.635
Diaminopimelate dehydrogenase -0.228 0.293 0.436 0.635
Diaminopimelate epimerase -0.394 0.395 0.320 0.635
Dihydrofolate reductase -0.201 0.284 0.481 0.635
Dihydrofolate synthase -0.230 0.296 0.438 0.635
Dihydrolipoyl dehydrogenase -0.190 0.321 0.556 0.680
Dihydroneopterin aldolase -0.230 0.296 0.438 0.635
Dihydroorotase -0.220 0.308 0.477 0.635
Dihydroorotate dehydrogenase (NAD(+)) -0.230 0.296 0.438 0.635
Dihydropteroate synthase -0.230 0.296 0.438 0.635
Dihydroxy-acid dehydratase -0.548 0.584 0.350 0.635
Dimethylallyltranstransferase -0.230 0.296 0.438 0.635
Dipeptidase E -0.619 0.514 0.230 0.635
Dipeptidyl-peptidase III -0.230 0.296 0.438 0.635
Dipeptidyl-peptidase IV -0.230 0.296 0.438 0.635
Diphosphate–fructose-6-phosphate 1-phosphotransferase -0.230 0.296 0.438 0.635
diphosphate specific) -0.230 0.296 0.438 0.635
DNA-(apurinic or apyrimidinic site) lyase -0.138 0.295 0.642 0.745
DNA-3-methyladenine glycosylase I -0.227 0.333 0.497 0.635
DNA-directed DNA polymerase -0.228 0.295 0.441 0.635
DNA-directed RNA polymerase -0.227 0.300 0.450 0.635
DNA (cytosine-5-)-methyltransferase -0.244 0.306 0.427 0.635
DNA helicase -0.238 0.300 0.428 0.635
DNA ligase (NAD(+)) -0.230 0.296 0.438 0.635
DNA topoisomerase -0.294 0.331 0.376 0.635
DNA topoisomerase (ATP-hydrolyzing) -0.230 0.296 0.438 0.635
Dolichyl-phosphate beta-D-mannosyltransferase -0.230 0.296 0.438 0.635
dTDP-4-dehydrorhamnose 3,5-epimerase -0.230 0.296 0.438 0.635
dTDP-4-dehydrorhamnose reductase -0.230 0.296 0.438 0.635
dTDP-glucose 4,6-dehydratase -0.230 0.296 0.438 0.635
dUTP diphosphatase -0.230 0.296 0.438 0.635
Endo-1,4-beta-xylanase 18.519 3411.091 0.996 0.997
Endopeptidase Clp -0.230 0.296 0.438 0.635
Endopeptidase La -0.220 0.308 0.477 0.635
Enoyl-[acyl-carrier-protein] reductase (NADH) -0.219 0.301 0.468 0.635
Enoyl-[acyl-carrier-protein] reductase (NADPH, Si-specific) -0.219 0.301 0.468 0.635
Epoxyqueuosine reductase -0.230 0.296 0.438 0.635
Exo-1,4-beta-D-glucosaminidase -2.232 1.933 0.250 0.635
Exo-alpha-sialidase -0.234 0.288 0.419 0.635
Exodeoxyribonuclease III -0.138 0.295 0.642 0.745
Exodeoxyribonuclease V -0.754 1.120 0.502 0.635
Exodeoxyribonuclease VII -0.230 0.296 0.438 0.635
FAD synthetase -0.230 0.296 0.438 0.635
FMN reductase (NAD(P)H) -0.230 0.296 0.438 0.635
Formate–tetrahydrofolate ligase -0.263 0.312 0.401 0.635
Formate C-acetyltransferase -0.215 0.295 0.468 0.635
Formimidoyltetrahydrofolate cyclodeaminase -0.162 0.333 0.626 0.734
Formyltetrahydrofolate deformylase -0.789 0.881 0.372 0.635
Fructan beta-fructosidase -0.268 0.313 0.394 0.635
Fructokinase -0.239 0.302 0.431 0.635
Fructose-bisphosphatase -0.230 0.296 0.438 0.635
Fructose-bisphosphate aldolase -0.230 0.296 0.438 0.635
Fructuronate reductase -0.677 0.652 0.301 0.635
Fumarate hydratase -0.228 0.345 0.510 0.635
Fumarate reductase (quinol) -0.230 0.296 0.438 0.635
Galactokinase -0.224 0.269 0.406 0.635
Galactoside O-acetyltransferase -0.062 0.367 0.865 0.945
GDP-L-fucose synthase -0.230 0.296 0.438 0.635
GDP-mannose 4,6-dehydratase -0.230 0.296 0.438 0.635
Geranylgeranyl diphosphate synthase -0.230 0.296 0.438 0.635
Gingipain R -0.001 1.049 0.999 0.999
Glucokinase -0.268 0.292 0.361 0.635
Gluconate 5-dehydrogenase -0.542 0.584 0.355 0.635
Glucosamine-6-phosphate deaminase -0.226 0.290 0.438 0.635
Glucose-1-phosphatase -0.072 0.305 0.815 0.904
Glucose-1-phosphate thymidylyltransferase -0.230 0.296 0.438 0.635
Glucose-6-phosphate isomerase -0.230 0.296 0.438 0.635
Glucosylceramidase 0.151 1.352 0.911 0.968
Glucuronate isomerase -0.839 0.582 0.151 0.635
Glutamate–ammonia ligase -0.204 0.294 0.489 0.635
Glutamate–tRNA ligase -0.230 0.296 0.438 0.635
Glutamate-5-semialdehyde dehydrogenase 18.519 3411.091 0.996 0.997
Glutamate 5-kinase 18.519 3411.091 0.996 0.997
Glutamate dehydrogenase (NADP(+)) -0.154 0.290 0.596 0.718
Glutamate formimidoyltransferase -0.162 0.333 0.626 0.734
Glutamate racemase -0.230 0.296 0.438 0.635
Glutamate synthase (NADH) -0.323 0.318 0.311 0.635
Glutamate synthase (NADPH) -0.323 0.318 0.311 0.635
Glutamine–fructose-6-phosphate transaminase (isomerizing) -0.243 0.311 0.436 0.635
Glutamine–tRNA ligase -0.230 0.296 0.438 0.635
Glutathione peroxidase -0.203 0.301 0.502 0.635
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) -0.230 0.296 0.438 0.635
Glycerate 3-kinase -0.206 0.323 0.524 0.647
Glycerate dehydrogenase -0.230 0.296 0.438 0.635
Glycerol-3-phosphate cytidylyltransferase 0.358 0.550 0.516 0.641
Glycerol-3-phosphate dehydrogenase -0.228 0.331 0.492 0.635
Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) -0.230 0.296 0.438 0.635
Glycerol kinase -0.075 0.341 0.826 0.905
Glycerophosphodiester phosphodiesterase -0.647 0.496 0.194 0.635
Glycine–tRNA ligase -0.230 0.296 0.438 0.635
Glycine C-acetyltransferase -0.323 0.372 0.387 0.635
Glycine dehydrogenase (aminomethyl-transferring) -0.190 0.321 0.556 0.680
Glycine hydroxymethyltransferase -0.230 0.296 0.438 0.635
Glycogen phosphorylase -0.230 0.296 0.438 0.635
GMP synthase (glutamine-hydrolyzing) -0.230 0.296 0.438 0.635
GTP cyclohydrolase I -0.201 0.284 0.481 0.635
GTP cyclohydrolase II -0.231 0.296 0.437 0.635
GTP diphosphokinase -0.231 0.299 0.439 0.635
Guanylate kinase -0.230 0.296 0.438 0.635
H(+)-transporting two-sector ATPase -0.237 0.295 0.423 0.635
Hippurate hydrolase -1.546 2.070 0.456 0.635
Histidine–tRNA ligase -0.230 0.296 0.438 0.635
Histidine ammonia-lyase -0.162 0.333 0.626 0.734
Histidine kinase -0.226 0.296 0.445 0.635
Histidinol-phosphatase -0.100 1.127 0.930 0.968
Histidinol-phosphate transaminase -0.159 0.284 0.576 0.702
Histidinol dehydrogenase -0.100 1.127 0.930 0.968
Homoserine dehydrogenase -0.274 0.307 0.374 0.635
Homoserine O-succinyltransferase -0.274 0.307 0.374 0.635
Hyaluronoglucosaminidase -0.247 0.317 0.437 0.635
Hydroxylamine reductase -0.206 0.301 0.494 0.635
Hydroxymethylpyrimidine kinase -0.134 0.312 0.669 0.765
Hypoxanthine phosphoribosyltransferase -0.230 0.296 0.438 0.635
Imidazoleglycerol-phosphate dehydratase -0.100 1.127 0.930 0.968
Imidazolonepropionase -0.162 0.333 0.626 0.734
IMP cyclohydrolase -0.230 0.296 0.438 0.635
IMP dehydrogenase -0.230 0.296 0.438 0.635
Indole-3-glycerol-phosphate synthase -0.376 0.442 0.397 0.635
Inorganic diphosphatase -0.240 0.317 0.450 0.635
Inositol-3-phosphate synthase -0.144 0.334 0.667 0.765
Iron-chelate-transporting ATPase -0.230 0.296 0.438 0.635
Isochorismate synthase -0.230 0.296 0.438 0.635
Isocitrate dehydrogenase (NADP(+)) -0.429 1.387 0.758 0.845
Isoleucine–tRNA ligase -0.220 0.308 0.477 0.635
isomerase -0.100 1.127 0.930 0.968
Kdo(2)-lipid IV(A) lauroyltransferase -0.230 0.296 0.438 0.635
Ketol-acid reductoisomerase (NADP(+)) -0.548 0.584 0.350 0.635
L-arabinose isomerase -0.670 0.642 0.298 0.635
L-aspartate oxidase -0.172 0.328 0.602 0.718
L-rhamnose isomerase -0.810 0.830 0.330 0.635
L-rhamnose mutarotase -0.846 0.965 0.382 0.635
L-ribulose-5-phosphate 4-epimerase -0.670 0.642 0.298 0.635
L-serine ammonia-lyase -0.230 0.296 0.438 0.635
L-threonine aldolase -0.170 0.761 0.824 0.905
L-threonylcarbamoyladenylate synthase -0.230 0.296 0.438 0.635
Lactoylglutathione lyase -1.045 0.919 0.257 0.635
Leucine–tRNA ligase -0.222 0.299 0.458 0.635
Leucyltransferase 0.056 0.493 0.910 0.968
Levanase -0.223 0.321 0.489 0.635
Lipid-A-disaccharide synthase -0.230 0.296 0.438 0.635
Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase -0.230 0.296 0.438 0.635
Lipoate–protein ligase -0.717 0.722 0.322 0.635
Lipoyl synthase -0.230 0.317 0.469 0.635
LL-diaminopimelate aminotransferase -0.394 0.395 0.320 0.635
Long-chain-fatty-acid–CoA ligase -0.247 0.302 0.414 0.635
Lysine–tRNA ligase -0.230 0.296 0.438 0.635
Lysozyme 0.038 0.447 0.932 0.968
Malate dehydrogenase -0.230 0.296 0.438 0.635
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) -0.230 0.296 0.438 0.635
Maltose alpha-D-glucosyltransferase -0.629 0.781 0.422 0.635
Maltose O-acetyltransferase -0.230 0.328 0.484 0.635
Mannan endo-1,4-beta-mannosidase -0.329 0.354 0.354 0.635
Mannonate dehydratase -0.692 0.616 0.263 0.635
Mannose-1-phosphate guanylyltransferase -0.230 0.296 0.438 0.635
Mannose-6-phosphate isomerase -0.230 0.296 0.438 0.635
Methenyltetrahydrofolate cyclohydrolase -0.230 0.296 0.438 0.635
Methionine–tRNA ligase -0.230 0.296 0.438 0.635
Methionine adenosyltransferase -0.243 0.292 0.407 0.635
Methionine synthase -0.206 0.312 0.510 0.635
Methionyl-tRNA formyltransferase -0.230 0.296 0.438 0.635
Methionyl aminopeptidase -0.224 0.289 0.440 0.635
Methylaspartate ammonia-lyase -0.221 0.572 0.699 0.790
Methylaspartate mutase -0.221 0.572 0.699 0.790
Methylated-DNA–[protein]-cysteine S-methyltransferase -0.230 0.296 0.438 0.635
Methylenetetrahydrofolate dehydrogenase (NADP(+)) -0.230 0.296 0.438 0.635
Methylenetetrahydrofolate reductase (NAD(P)H) -0.264 0.307 0.391 0.635
Methylmalonyl-CoA mutase -0.246 0.310 0.427 0.635
N-acetyl-gamma-glutamyl-phosphate reductase -0.100 1.127 0.930 0.968
N-acetylmuramic acid 6-phosphate etherase -0.747 0.519 0.152 0.635
N-acetylmuramoyl-L-alanine amidase -0.285 0.315 0.367 0.635
N-acetylneuraminate lyase -0.206 0.295 0.486 0.635
N-acetylneuraminate synthase -2.232 1.933 0.250 0.635
N-acylglucosamine 2-epimerase -0.240 0.289 0.409 0.635
N-acylneuraminate cytidylyltransferase -2.232 1.933 0.250 0.635
N-carbamoylputrescine amidase -0.230 0.296 0.438 0.635
N-succinylornithine carbamoyltransferase -0.100 1.127 0.930 0.968
N(6)-L-threonylcarbamoyladenine synthase -0.230 0.296 0.438 0.635
NAD(+) diphosphatase -0.230 0.296 0.438 0.635
NAD(+) kinase -0.230 0.296 0.438 0.635
NAD(+) synthase (glutamine-hydrolyzing) -0.230 0.296 0.438 0.635
NAD(P)H-hydrate epimerase -0.230 0.296 0.438 0.635
NADH dehydrogenase -0.211 0.290 0.469 0.635
NADH:ubiquinone reductase (H(+)-translocating) -0.230 0.296 0.438 0.635
Nicotinamidase -0.097 0.315 0.757 0.845
Nicotinamide-nucleotide amidase -0.230 0.296 0.438 0.635
Nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase -0.680 0.538 0.208 0.635
Nicotinate-nucleotide adenylyltransferase -0.230 0.296 0.438 0.635
Nicotinate-nucleotide diphosphorylase (carboxylating) -0.172 0.328 0.602 0.718
Nicotinate phosphoribosyltransferase -0.231 0.296 0.438 0.635
Nitric-oxide reductase (cytochrome c) 0.054 0.493 0.913 0.968
Nitrite reductase (cytochrome; ammonia-forming) -0.217 0.299 0.469 0.635
Nitrous-oxide reductase -0.319 0.983 0.746 0.837
Non-reducing end alpha-L-arabinofuranosidase -0.691 0.615 0.263 0.635
Non-specific serine/threonine protein kinase -0.044 0.314 0.889 0.968
Nucleoside-diphosphate kinase -0.754 1.120 0.502 0.635
O-acetylhomoserine aminocarboxypropyltransferase -0.208 0.306 0.498 0.635
o-succinylbenzoate–CoA ligase -0.219 0.301 0.468 0.635
Oligonucleotidase -0.230 0.296 0.438 0.635
Orotate phosphoribosyltransferase -0.230 0.296 0.438 0.635
Orotidine-5’-phosphate decarboxylase -0.230 0.296 0.438 0.635
Pantetheine-phosphate adenylyltransferase -0.230 0.296 0.438 0.635
Pantoate–beta-alanine ligase (AMP-forming) -0.213 0.298 0.477 0.635
Pantothenate kinase -0.230 0.296 0.438 0.635
Pectinesterase -0.674 0.651 0.302 0.635
Peptide-methionine (R)-S-oxide reductase -0.230 0.296 0.438 0.635
Peptide-methionine (S)-S-oxide reductase -0.230 0.296 0.438 0.635
Peptide chain release factor N(5)-glutamine methyltransferase -0.230 0.296 0.438 0.635
Peptide deformylase -0.230 0.296 0.438 0.635
Peptidyl-dipeptidase Dcp -0.233 0.311 0.453 0.635
Peptidylprolyl isomerase -0.215 0.294 0.466 0.635
Peroxiredoxin -0.236 0.295 0.424 0.635
Phenylalanine–tRNA ligase -0.230 0.296 0.438 0.635
Phosphate acetyltransferase -0.230 0.296 0.438 0.635
Phosphate butyryltransferase -0.147 0.329 0.655 0.755
Phosphatidate cytidylyltransferase -0.230 0.296 0.438 0.635
Phosphatidylglycerophosphatase -0.015 0.569 0.979 0.997
Phosphatidylserine decarboxylase -0.230 0.296 0.438 0.635
Phospho-N-acetylmuramoyl-pentapeptide-transferase -0.230 0.296 0.438 0.635
Phosphoadenylyl-sulfate reductase (thioredoxin) 18.519 3411.091 0.996 0.997
Phosphoenolpyruvate carboxykinase (ATP) -0.230 0.296 0.438 0.635
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent) -0.230 0.296 0.438 0.635
Phosphoglycerate dehydrogenase -0.228 0.293 0.436 0.635
Phosphoglycerate kinase -0.230 0.296 0.438 0.635
Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) 0.038 0.480 0.937 0.969
Phosphoglycerate mutase (2,3-diphosphoglycerate-independent) -0.291 0.314 0.356 0.635
Phosphoglycolate phosphatase -0.223 0.280 0.427 0.635
Phosphomannomutase -0.230 0.296 0.438 0.635
Phosphomethylpyrimidine kinase -0.134 0.312 0.669 0.765
Phosphomethylpyrimidine synthase 0.014 0.383 0.970 0.997
Phosphopantothenate–cysteine ligase -0.213 0.298 0.477 0.635
Phosphopantothenoylcysteine decarboxylase -0.213 0.298 0.477 0.635
Phosphopyruvate hydratase -0.230 0.296 0.438 0.635
Phosphoribosyl-AMP cyclohydrolase -0.100 1.127 0.930 0.968
Phosphoribosyl-ATP diphosphatase -0.100 1.127 0.930 0.968
Phosphoribosyl 1,2-cyclic phosphate phosphodiesterase -0.230 0.296 0.438 0.635
Phosphoribosylamine–glycine ligase -0.230 0.296 0.438 0.635
Phosphoribosylaminoimidazolecarboxamide formyltransferase -0.230 0.296 0.438 0.635
Phosphoribosylaminoimidazolesuccinocarboxamide synthase -0.230 0.296 0.438 0.635
Phosphoribosylanthranilate isomerase -0.219 0.301 0.468 0.635
Phosphoribosylformylglycinamidine cyclo-ligase -0.230 0.296 0.438 0.635
Phosphoribosylformylglycinamidine synthase -0.220 0.308 0.477 0.635
Phosphoribosylglycinamide formyltransferase -0.219 0.308 0.477 0.635
Phosphoserine phosphatase -0.237 0.319 0.459 0.635
Phosphoserine transaminase -0.228 0.293 0.436 0.635
Polar-amino-acid-transporting ATPase -2.168 1.874 0.249 0.635
Polynucleotide adenylyltransferase -0.754 1.120 0.502 0.635
Polyribonucleotide nucleotidyltransferase -0.230 0.296 0.438 0.635
Potassium-transporting ATPase 2.304 1.989 0.248 0.635
Prephenate dehydratase -0.644 0.452 0.157 0.635
PreQ(1) synthase -0.230 0.296 0.438 0.635
Proline–tRNA ligase -0.230 0.296 0.438 0.635
Prolyl aminopeptidase 18.519 3411.091 0.996 0.997
Prolyl oligopeptidase -0.210 0.327 0.521 0.645
Protein-disulfide reductase -0.230 0.296 0.438 0.635
Protein-L-isoaspartate(D-aspartate) O-methyltransferase -0.137 0.613 0.823 0.905
Protein-tyrosine-phosphatase -0.237 0.301 0.432 0.635
Protoporphyrinogen oxidase -0.232 0.293 0.430 0.635
Pullulanase -0.252 0.318 0.429 0.635
Purine-nucleoside phosphorylase -0.230 0.296 0.438 0.635
Pyridoxal 5’-phosphate synthase (glutamine hydrolyzing) -0.219 0.301 0.468 0.635
Pyridoxal kinase -0.186 0.306 0.545 0.671
Pyridoxine 5’-phosphate synthase -0.754 1.120 0.502 0.635
Pyrroline-5-carboxylate reductase 0.139 1.250 0.912 0.968
Pyruvate carboxylase -0.230 0.296 0.438 0.635
Pyruvate kinase -0.230 0.296 0.438 0.635
Pyruvate synthase -0.230 0.296 0.438 0.635
Pyruvate, phosphate dikinase -0.230 0.296 0.438 0.635
Quinolinate synthase -0.172 0.328 0.602 0.718
Rhamnulokinase -0.810 0.830 0.330 0.635
Rhamnulose-1-phosphate aldolase -0.810 0.830 0.330 0.635
Riboflavin kinase -0.230 0.296 0.438 0.635
Riboflavin synthase -0.230 0.296 0.438 0.635
Ribonuclease H -0.230 0.296 0.438 0.635
Ribonuclease III -0.217 0.299 0.469 0.635
Ribonuclease P -0.230 0.296 0.438 0.635
Ribonuclease Z -0.230 0.296 0.438 0.635
Ribonucleoside-diphosphate reductase -0.160 0.292 0.584 0.707
Ribonucleoside-triphosphate reductase -0.230 0.296 0.438 0.635
Ribose-5-phosphate isomerase -0.230 0.296 0.438 0.635
Ribose-phosphate diphosphokinase -0.230 0.296 0.438 0.635
Ribulose-phosphate 3-epimerase -0.230 0.296 0.438 0.635
RNA-directed DNA polymerase 2.304 1.989 0.248 0.635
RNA helicase -0.230 0.296 0.438 0.635
RNA ligase (ATP) -2.232 1.933 0.250 0.635
S-adenosylmethionine:tRNA ribosyltransferase-isomerase -0.225 0.301 0.457 0.635
S-ribosylhomocysteine lyase -0.263 0.312 0.401 0.635
Saccharopine dehydrogenase (NAD(+), L-lysine-forming) -0.230 0.296 0.438 0.635
Selenocysteine lyase -0.230 0.296 0.438 0.635
Serine–tRNA ligase -0.230 0.296 0.438 0.635
Serine-type D-Ala-D-Ala carboxypeptidase -0.288 0.314 0.360 0.635
Serine O-acetyltransferase -0.157 0.290 0.590 0.713
Shikimate dehydrogenase -0.230 0.296 0.438 0.635
Shikimate kinase -0.230 0.296 0.438 0.635
Sialate O-acetylesterase -0.283 0.313 0.368 0.635
Signal peptidase I -0.223 0.297 0.456 0.635
Signal peptidase II -0.230 0.296 0.438 0.635
Site-specific DNA-methyltransferase (adenine-specific) -0.214 0.306 0.485 0.635
Starch synthase -0.230 0.296 0.438 0.635
Succinate–CoA ligase (ADP-forming) -0.173 0.329 0.600 0.718
Succinate dehydrogenase (quinone) -0.230 0.296 0.438 0.635
Sulfate adenylyltransferase -0.754 1.120 0.502 0.635
Superoxide dismutase -0.396 0.395 0.317 0.635
Superoxide reductase -0.166 0.321 0.605 0.718
synthase -0.230 0.296 0.438 0.635
Tagaturonate reductase -0.676 0.652 0.302 0.635
Tetraacyldisaccharide 4’-kinase -0.230 0.296 0.438 0.635
Tetrahydrofolate synthase -0.230 0.296 0.438 0.635
Thiamine-phosphate diphosphorylase -0.063 0.337 0.853 0.934
Thiamine-phosphate kinase -0.230 0.296 0.438 0.635
Thiamine diphosphokinase -0.198 0.307 0.519 0.643
Thiazole synthase 18.519 3411.091 0.996 0.997
Thioredoxin-disulfide reductase -0.230 0.296 0.438 0.635
Threonine–tRNA ligase -0.230 0.296 0.438 0.635
Threonine ammonia-lyase -0.378 0.462 0.414 0.635
Threonine synthase -0.606 0.561 0.282 0.635
Thymidine kinase -0.230 0.296 0.438 0.635
Thymidylate synthase -0.172 0.309 0.579 0.704
Thymidylate synthase (FAD) -0.625 0.575 0.278 0.635
Transketolase -0.234 0.306 0.446 0.635
Triose-phosphate isomerase -0.240 0.307 0.435 0.635
Tripeptide aminopeptidase -0.230 0.296 0.438 0.635
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase -0.230 0.296 0.438 0.635
tRNA-guanine(34) transglycosylase -0.230 0.296 0.438 0.635
tRNA (guanine(37)-N(1))-methyltransferase -0.230 0.296 0.438 0.635
tRNA (guanine(46)-N(7))-methyltransferase -0.230 0.296 0.438 0.635
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase -0.230 0.296 0.438 0.635
tRNA dimethylallyltransferase -0.230 0.296 0.438 0.635
tRNA pseudouridine(32) synthase -0.223 0.336 0.508 0.635
tRNA pseudouridine(38-40) synthase -0.230 0.296 0.438 0.635
tRNA pseudouridine(55) synthase -0.230 0.296 0.438 0.635
tRNA(1)(Val) (adenine(37)-N(6))-methyltransferase -0.230 0.296 0.438 0.635
tRNA(adenine(34)) deaminase -0.230 0.296 0.438 0.635
tRNA(Ile)-lysidine synthetase -0.230 0.296 0.438 0.635
Tryptophan–tRNA ligase -0.230 0.296 0.438 0.635
Tryptophan synthase -0.229 0.301 0.447 0.635
Tryptophanase -0.221 0.572 0.699 0.790
Type I site-specific deoxyribonuclease -0.237 0.303 0.435 0.635
Type II site-specific deoxyribonuclease -0.343 0.461 0.459 0.635
Type III site-specific deoxyribonuclease -5.080 10.936 0.643 0.745
Tyrosine–tRNA ligase -0.230 0.296 0.438 0.635
UDP-2,3-diacylglucosamine diphosphatase -0.230 0.296 0.438 0.635
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -0.230 0.296 0.438 0.635
UDP-3-O-acyl-N-acetylglucosamine deacetylase -0.230 0.296 0.438 0.635
UDP-galactopyranose mutase -0.337 0.418 0.421 0.635
UDP-glucose 4-epimerase -0.241 0.294 0.412 0.635
UDP-glucose 6-dehydrogenase -0.219 0.308 0.477 0.635
UDP-glucuronate 4-epimerase -0.057 0.574 0.921 0.968
UDP-glucuronate decarboxylase -0.137 0.613 0.823 0.905
UDP-N-acetylglucosamine 1-carboxyvinyltransferase -0.230 0.296 0.438 0.635
UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -0.287 0.294 0.330 0.635
UDP-N-acetylmuramate–L-alanine ligase -0.230 0.296 0.438 0.635
UDP-N-acetylmuramate dehydrogenase -0.230 0.296 0.438 0.635
UDP-N-acetylmuramoyl-L-alanine–D-glutamate ligase -0.230 0.296 0.438 0.635
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase -0.230 0.296 0.438 0.635
UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase -0.230 0.296 0.438 0.635
UMP kinase -0.230 0.296 0.438 0.635
UMP/CMP kinase -0.230 0.296 0.438 0.635
Undecaprenyl-diphosphate phosphatase -0.274 0.301 0.364 0.635
Uracil-DNA glycosylase -0.204 0.307 0.507 0.635
Uracil phosphoribosyltransferase -0.230 0.296 0.438 0.635
Uridine kinase -0.230 0.296 0.438 0.635
Uridine phosphorylase -0.230 0.296 0.438 0.635
Urocanate hydratase -0.162 0.333 0.626 0.734
Uroporphyrinogen-III synthase -0.248 0.296 0.403 0.635
Valine–tRNA ligase -0.230 0.296 0.438 0.635
Xaa-Pro aminopeptidase -0.233 0.297 0.434 0.635
Xanthine phosphoribosyltransferase -0.156 0.300 0.605 0.718
XTP/dITP diphosphatase -0.230 0.296 0.438 0.635
Xylose isomerase -0.092 1.135 0.935 0.969
Xylulokinase -0.546 0.585 0.352 0.635
Zinc-exporting ATPase -0.201 0.284 0.481 0.635 
# merge with tb.ra for full results table
full.res <- left_join(tb.ra, results.out, by = "description")

write.csv(full.res, "output/picrust_ec_stratefied_prevo_data_results.csv", row.names = F)

Part 2 KO Data

descriptions <- readr::read_tsv("data/PICRUST/ko_pred_metagenome_unstrat_descrip.tsv")[,1:2] %>%
  distinct()

-- Column specification --------------------------------------------------------
cols(
  .default = col_double(),
  `function` = col_character(),
  description = col_character()
)
i Use `spec()` for the full column specifications.
colnames(descriptions) <- c("func", "description")

pi.dat <- readxl::read_xlsx("data/PICRUST-Stratified/KO_prevo.xlsx")
colnames(pi.dat) <- c("func",  colnames(pi.dat)[-c(1)])

# add descriptions to dataframe
pi.dat <- left_join(pi.dat, descriptions, by="func")
pi.dat <- pi.dat[,c(1,161,3:160)]

# aggregate descriptions to get 1 description per row - unique;y defined.
pi.dat <- pi.dat %>%
  group_by(description) %>%
  summarise(across(`X1.S37.Jun172016`:`X99.D01.S37.Jun232016`,.fns = sum))

# make long format
pi.dat <- pi.dat %>%
  pivot_longer(
    cols=`X1.S37.Jun172016`:`X99.D01.S37.Jun232016`,
    names_to = "ID",
    values_to = "Abundance"
  ) %>%
  mutate(
    ID = substr(ID, 2, 99)
  )

d <- as.data.frame(dat.16s)
mydata <- full_join(pi.dat, d)
Joining, by = "ID"
Warning in class(x) <- c(setdiff(subclass, tibble_class), tibble_class): Setting
class(x) to multiple strings ("tbl_df", "tbl", ...); result will no longer be an
S4 object
mydata <- mydata %>%
  mutate(
    ID.n = as.numeric(as.factor(ID)),
    description.n = as.numeric(as.factor(description))
  ) %>%
  group_by(ID) %>%
  mutate(
    dem = ifelse(sum(Abundance)==0, 1, sum(Abundance)),
    RelAbundance = Abundance/dem*100) %>%
  ungroup()%>%
  group_by(description)%>%
  mutate(avgRA = mean(RelAbundance))

Abundance

# Run on all descriptions
tb.ra1 <- mydata %>%
  group_by(description) %>%
  summarise(ng = n(),
            Overall.M = mean(RelAbundance),
            Overall.SE = sd(RelAbundance)/sqrt(ng))
tb.ra2m <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(M = mean(RelAbundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = M)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra2se <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(),SE = sd(RelAbundance)/sqrt(ng)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = SE)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra2var <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(), VAR = var(RelAbundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = VAR)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra2ng <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n()) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = ng)
`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.
tb.ra <- left_join(tb.ra1, tb.ra2m)
Joining, by = "description"
tb.ra <- cbind(tb.ra, tb.ra2se[,-1])
tb.ra <- cbind(tb.ra, tb.ra2var[,-1])
tb.ra <- cbind(tb.ra, tb.ra2ng[,-1]) 

colnames(tb.ra) <- c("description", "ng", "Overall Mean", "Overall SE", "Non-Tumor Mean", "Tumor Mean", "Non-Tumor SE", "Tumor SE","Non-Tumor Var", "Tumor Var", "Non-Tumor Ng", "Tumor Ng")
tb.ra <- tb.ra %>%
  arrange(desc(`Overall Mean`))
tb.ra <- tb.ra[, c("description", "Overall Mean", "Overall SE","Tumor Mean","Tumor Var", "Tumor SE","Tumor Ng", "Non-Tumor Mean","Non-Tumor Var", "Non-Tumor SE", "Non-Tumor Ng")]

# compute t-test
tb.ra <- tb.ra %>%
  mutate(
    SEpooled = sqrt(`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`),
    t = (`Tumor Mean` - `Non-Tumor Mean`)/(SEpooled),
    df = ((`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`)**2)/(((`Tumor Var`/`Tumor Ng`)**2)/(`Tumor Ng`-1) + ((`Non-Tumor Var`/`Non-Tumor Ng`)**2)/(`Non-Tumor Ng`-1)),
    p = pt(q = abs(t), df=df, lower.tail = F)*2,
    fdr_p = p.adjust(p, method="fdr")
  )


kable(tb.ra, format="html", digits=5, caption="Stratefied KO Data - Prevotella spp. (genus level only): Average RelAbundance of Each Description (sorted in descending order)") %>%
  kable_styling(full_width = T) %>%
  scroll_box(width = "100%", height="600px")
Stratefied KO Data - Prevotella spp. (genus level only): Average RelAbundance of Each Description (sorted in descending order)
description Overall Mean Overall SE Tumor Mean Tumor Var Tumor SE Tumor Ng Non-Tumor Mean Non-Tumor Var Non-Tumor SE Non-Tumor Ng SEpooled t df p fdr_p
rpoE; RNA polymerase sigma-70 factor, ECF subfamily 0.60820 0.03108 0.64798 0.12618 0.04406 65 0.58039 0.17083 0.04286 93 0.06147 1.09959 149.379 0.27328 0.40992
TC.FEV.OM; iron complex outermembrane recepter protein 0.56645 0.02877 0.61137 0.11142 0.04140 65 0.53505 0.14332 0.03926 93 0.05705 1.33758 147.737 0.18309 0.30818
ABCB-BAC; ATP-binding cassette, subfamily B, bacterial 0.33043 0.01770 0.35661 0.04427 0.02610 65 0.31213 0.05287 0.02384 93 0.03535 1.25829 145.101 0.21031 0.34268
fklB; FKBP-type peptidyl-prolyl cis-trans isomerase FklB [EC:5.2.1.8] 0.31007 0.01556 0.34047 0.03353 0.02271 65 0.28883 0.04087 0.02096 93 0.03091 1.67089 145.859 0.09689 0.23153
hlpA, ompH; outer membrane protein 0.30286 0.01505 0.33066 0.03064 0.02171 65 0.28344 0.03881 0.02043 93 0.02981 1.58388 147.213 0.11537 0.23153
acm; lysozyme 0.29051 0.01543 0.31531 0.03337 0.02266 65 0.27317 0.04027 0.02081 93 0.03076 1.37007 145.497 0.17278 0.29466
ABC-2.P; ABC-2 type transport system permease protein 0.28741 0.01529 0.31044 0.03292 0.02251 65 0.27131 0.03952 0.02061 93 0.03052 1.28199 145.292 0.20189 0.33020
tonB; periplasmic protein TonB 0.27255 0.01476 0.30222 0.03252 0.02237 65 0.25182 0.03510 0.01943 93 0.02963 1.70106 141.125 0.09113 0.23153
topB; DNA topoisomerase III [EC:5.99.1.2] 0.24004 0.01388 0.25976 0.02789 0.02072 65 0.22626 0.03209 0.01858 93 0.02782 1.20375 143.677 0.23066 0.36341
hupB; DNA-binding protein HU-beta 0.23916 0.01204 0.25950 0.01946 0.01730 65 0.22494 0.02505 0.01641 93 0.02385 1.44928 147.758 0.14938 0.27457
E3.4.21.102, prc, ctpA; carboxyl-terminal processing protease [EC:3.4.21.102] 0.22715 0.01129 0.24799 0.01724 0.01628 65 0.21258 0.02183 0.01532 93 0.02236 1.58388 147.213 0.11537 0.23153
rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] 0.22715 0.01129 0.24799 0.01724 0.01628 65 0.21258 0.02183 0.01532 93 0.02236 1.58388 147.213 0.11537 0.23153
ABC-2.A; ABC-2 type transport system ATP-binding protein 0.22551 0.01205 0.24118 0.02031 0.01768 65 0.21456 0.02476 0.01632 93 0.02406 1.10671 145.859 0.27024 0.40626
pqqL; zinc protease [EC:3.4.24.-] 0.22030 0.01175 0.24047 0.01899 0.01709 65 0.20621 0.02350 0.01590 93 0.02334 1.46745 146.397 0.14440 0.26754
rpoD; RNA polymerase primary sigma factor 0.21601 0.01084 0.23685 0.01607 0.01572 65 0.20144 0.02001 0.01467 93 0.02150 1.64697 146.628 0.10171 0.23153
HEXA_B; hexosaminidase [EC:3.2.1.52] 0.21344 0.01346 0.23216 0.02826 0.02085 65 0.20037 0.02879 0.01759 93 0.02728 1.16526 138.671 0.24592 0.38224
K07133; uncharacterized protein 0.21333 0.01136 0.23039 0.01800 0.01664 65 0.20140 0.02192 0.01535 93 0.02264 1.28013 145.825 0.20253 0.33080
lacZ; beta-galactosidase [EC:3.2.1.23] 0.21093 0.01242 0.22759 0.02244 0.01858 65 0.19928 0.02566 0.01661 93 0.02492 1.13591 143.443 0.25789 0.39294
ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3] 0.21016 0.01081 0.22473 0.01535 0.01537 65 0.19997 0.02056 0.01487 93 0.02138 1.15781 149.037 0.24879 0.38414
ampG; MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG 0.19585 0.01001 0.21459 0.01385 0.01460 65 0.18274 0.01696 0.01350 93 0.01989 1.60164 146.012 0.11140 0.23153
yfbK; Ca-activated chloride channel homolog 0.19015 0.00989 0.20627 0.01347 0.01440 65 0.17889 0.01667 0.01339 93 0.01966 1.39272 146.403 0.16581 0.29098
recG; ATP-dependent DNA helicase RecG [EC:3.6.4.12] 0.18742 0.01019 0.20431 0.01518 0.01528 65 0.17561 0.01707 0.01355 93 0.02042 1.40492 142.768 0.16222 0.28900
K07025; putative hydrolase of the HAD superfamily 0.18508 0.00979 0.20178 0.01313 0.01421 65 0.17341 0.01636 0.01326 93 0.01944 1.45885 146.647 0.14675 0.27108
gpx; glutathione peroxidase [EC:1.11.1.9] 0.17688 0.00942 0.19277 0.01262 0.01394 65 0.16577 0.01485 0.01264 93 0.01881 1.43485 144.544 0.15349 0.27772
FUCA; alpha-L-fucosidase [EC:3.2.1.51] 0.17043 0.00936 0.18172 0.01201 0.01359 65 0.16254 0.01510 0.01274 93 0.01863 1.02962 146.976 0.30488 0.43751
lacI, galR; LacI family transcriptional regulator 0.16916 0.00913 0.18385 0.01174 0.01344 65 0.15888 0.01403 0.01228 93 0.01821 1.37163 145.118 0.17230 0.29428
ENDOG; endonuclease G, mitochondrial 0.16836 0.00888 0.18396 0.01093 0.01297 65 0.15746 0.01336 0.01198 93 0.01766 1.50035 145.950 0.13568 0.25590
TC.FEV.OM2, cirA, cfrA, hmuR; outer membrane receptor for ferrienterochelin and colicins 0.16668 0.00890 0.18167 0.01139 0.01324 65 0.15621 0.01315 0.01189 93 0.01779 1.43096 143.815 0.15461 0.27888
parA, soj; chromosome partitioning protein 0.16529 0.00885 0.17727 0.01045 0.01268 65 0.15692 0.01366 0.01212 93 0.01754 1.16031 148.261 0.24779 0.38309
uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12] 0.15913 0.00814 0.17280 0.00900 0.01177 65 0.14957 0.01136 0.01105 93 0.01615 1.43841 147.074 0.15244 0.27669
uvrA; excinuclease ABC subunit A 0.15864 0.00812 0.17514 0.00942 0.01204 65 0.14711 0.01090 0.01083 93 0.01619 1.73161 143.909 0.08549 0.23153
dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] 0.15804 0.00812 0.17370 0.00944 0.01205 65 0.14709 0.01090 0.01082 93 0.01620 1.64266 143.819 0.10264 0.23153
recQ; ATP-dependent DNA helicase RecQ [EC:3.6.4.12] 0.15533 0.00782 0.16801 0.00806 0.01114 65 0.14647 0.01070 0.01073 93 0.01546 1.39343 148.774 0.16557 0.29098
K08303; putative protease [EC:3.4.-.-] 0.15450 0.00777 0.16977 0.00844 0.01139 65 0.14383 0.01015 0.01045 93 0.01546 1.67862 145.356 0.09537 0.23153
queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17] 0.15450 0.00777 0.16977 0.00844 0.01139 65 0.14383 0.01015 0.01045 93 0.01546 1.67862 145.356 0.09537 0.23153
relA; GTP pyrophosphokinase [EC:2.7.6.5] 0.15234 0.00758 0.16644 0.00779 0.01095 65 0.14249 0.00982 0.01028 93 0.01502 1.59496 147.049 0.11287 0.23153
manC, cpsB; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13] 0.15162 0.00753 0.16578 0.00771 0.01089 65 0.14172 0.00970 0.01021 93 0.01493 1.61144 146.984 0.10923 0.23153
clsA_B; cardiolipin synthase A/B [EC:2.7.8.-] 0.15143 0.00752 0.16533 0.00766 0.01086 65 0.14172 0.00970 0.01021 93 0.01491 1.58388 147.213 0.11537 0.23153
DPP4, CD26; dipeptidyl-peptidase 4 [EC:3.4.14.5] 0.15143 0.00752 0.16533 0.00766 0.01086 65 0.14172 0.00970 0.01021 93 0.01491 1.58388 147.213 0.11537 0.23153
fusA, GFM, EFG; elongation factor G 0.15143 0.00752 0.16533 0.00766 0.01086 65 0.14172 0.00970 0.01021 93 0.01491 1.58388 147.213 0.11537 0.23153
lolC_E; lipoprotein-releasing system permease protein 0.15143 0.00752 0.16533 0.00766 0.01086 65 0.14172 0.00970 0.01021 93 0.01491 1.58388 147.213 0.11537 0.23153
lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129] 0.15143 0.00752 0.16533 0.00766 0.01086 65 0.14172 0.00970 0.01021 93 0.01491 1.58388 147.213 0.11537 0.23153
miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75] 0.15143 0.00752 0.16533 0.00766 0.01086 65 0.14172 0.00970 0.01021 93 0.01491 1.58388 147.213 0.11537 0.23153
mrcA; penicillin-binding protein 1A [EC:2.4.1.129 3.4.16.4] 0.15143 0.00752 0.16533 0.00766 0.01086 65 0.14172 0.00970 0.01021 93 0.01491 1.58388 147.213 0.11537 0.23153
pepD; dipeptidase D [EC:3.4.13.-] 0.15143 0.00752 0.16533 0.00766 0.01086 65 0.14172 0.00970 0.01021 93 0.01491 1.58388 147.213 0.11537 0.23153
purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] 0.15143 0.00752 0.16533 0.00766 0.01086 65 0.14172 0.00970 0.01021 93 0.01491 1.58388 147.213 0.11537 0.23153
rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66] 0.15143 0.00752 0.16533 0.00766 0.01086 65 0.14172 0.00970 0.01021 93 0.01491 1.58388 147.213 0.11537 0.23153
surA; peptidyl-prolyl cis-trans isomerase SurA [EC:5.2.1.8] 0.15143 0.00752 0.16533 0.00766 0.01086 65 0.14172 0.00970 0.01021 93 0.01491 1.58388 147.213 0.11537 0.23153
udk, UCK; uridine kinase [EC:2.7.1.48] 0.15143 0.00752 0.16533 0.00766 0.01086 65 0.14172 0.00970 0.01021 93 0.01491 1.58388 147.213 0.11537 0.23153
pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9] 0.15083 0.00751 0.16388 0.00765 0.01085 65 0.14170 0.00970 0.01021 93 0.01490 1.48877 147.245 0.13869 0.26029
exbB; biopolymer transport protein ExbB 0.14964 0.00746 0.16364 0.00757 0.01079 65 0.13986 0.00952 0.01012 93 0.01479 1.60801 146.972 0.10998 0.23153
K06950; uncharacterized protein 0.14964 0.00746 0.16364 0.00757 0.01079 65 0.13986 0.00952 0.01012 93 0.01479 1.60801 146.972 0.10998 0.23153
BLMH, pepC; bleomycin hydrolase [EC:3.4.22.40] 0.14873 0.00743 0.16253 0.00749 0.01073 65 0.13909 0.00943 0.01007 93 0.01472 1.59272 147.007 0.11337 0.23153
hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3] 0.14845 0.00945 0.15496 0.01364 0.01448 65 0.14389 0.01455 0.01251 93 0.01914 0.57837 140.648 0.56394 0.66569
DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] 0.14785 0.00867 0.16112 0.01132 0.01320 65 0.13857 0.01219 0.01145 93 0.01747 1.29082 141.024 0.19888 0.32713
gph; phosphoglycolate phosphatase [EC:3.1.3.18] 0.14660 0.00778 0.16063 0.00873 0.01159 65 0.13680 0.01001 0.01037 93 0.01555 1.53227 143.569 0.12766 0.24515
dcp; peptidyl-dipeptidase Dcp [EC:3.4.15.5] 0.14537 0.00753 0.15942 0.00799 0.01109 65 0.13555 0.00949 0.01010 93 0.01500 1.59118 144.917 0.11375 0.23153
hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3] 0.14398 0.00732 0.15634 0.00741 0.01068 65 0.13535 0.00912 0.00990 93 0.01456 1.44105 146.185 0.15171 0.27622
ABC-2.TX; HlyD family secretion protein 0.14362 0.00727 0.15407 0.00712 0.01047 65 0.13631 0.00917 0.00993 93 0.01443 1.23056 147.762 0.22044 0.35455
coaE; dephospho-CoA kinase [EC:2.7.1.24] 0.14296 0.00724 0.15602 0.00711 0.01046 65 0.13384 0.00898 0.00983 93 0.01435 1.54529 147.100 0.12443 0.24217
K07098; uncharacterized protein 0.14256 0.00729 0.15464 0.00742 0.01068 65 0.13412 0.00901 0.00984 93 0.01453 1.41266 145.734 0.15989 0.28676
asnC; Lrp/AsnC family transcriptional regulator, regulator for asnA, asnC and gidA 0.14243 0.00721 0.15383 0.00704 0.01040 65 0.13447 0.00897 0.00982 93 0.01431 1.35304 147.433 0.17812 0.30243
korA, oorA, oforA; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11] 0.14225 0.00720 0.15337 0.00700 0.01038 65 0.13447 0.00897 0.00982 93 0.01429 1.32309 147.602 0.18785 0.31435
korB, oorB, oforB; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11] 0.14225 0.00720 0.15337 0.00700 0.01038 65 0.13447 0.00897 0.00982 93 0.01429 1.32309 147.602 0.18785 0.31435
ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60] 0.14184 0.00719 0.15383 0.00704 0.01040 65 0.13347 0.00887 0.00977 93 0.01427 1.42673 147.054 0.15578 0.28011
galM, GALM; aldose 1-epimerase [EC:5.1.3.3] 0.14183 0.00720 0.15238 0.00699 0.01037 65 0.13445 0.00897 0.00982 93 0.01428 1.25549 147.629 0.21129 0.34315
folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3] 0.14152 0.00717 0.15272 0.00694 0.01033 65 0.13370 0.00887 0.00977 93 0.01422 1.33756 147.553 0.18310 0.30818
TC.MATE, SLC47A, norM, mdtK, dinF; multidrug resistance protein, MATE family 0.14042 0.00721 0.15343 0.00713 0.01047 65 0.13134 0.00887 0.00977 93 0.01432 1.54262 146.622 0.12508 0.24217
chrA; chromate transporter 0.13987 0.00743 0.15047 0.00802 0.01111 65 0.13245 0.00918 0.00994 93 0.01491 1.20911 143.476 0.22861 0.36067
map; methionyl aminopeptidase [EC:3.4.11.18] 0.13852 0.00710 0.15048 0.00692 0.01031 65 0.13016 0.00859 0.00961 93 0.01410 1.44166 146.537 0.15153 0.27622
acrA, mexA, adeI, smeD, mtrC, cmeA; membrane fusion protein, multidrug efflux system 0.13744 0.00714 0.14860 0.00709 0.01045 65 0.12964 0.00868 0.00966 93 0.01423 1.33214 145.996 0.18489 0.31029
TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family 0.13744 0.00714 0.14860 0.00709 0.01045 65 0.12964 0.00868 0.00966 93 0.01423 1.33214 145.996 0.18489 0.31029
fur, zur, furB; Fur family transcriptional regulator, ferric uptake regulator 0.13611 0.00747 0.14338 0.00772 0.01090 65 0.13103 0.00961 0.01016 93 0.01490 0.82874 146.607 0.40860 0.52632
K07095; uncharacterized protein 0.13570 0.00739 0.14419 0.00785 0.01099 65 0.12976 0.00919 0.00994 93 0.01482 0.97385 144.345 0.33176 0.44209
SPP; sucrose-6-phosphatase [EC:3.1.3.24] 0.13269 0.00693 0.14663 0.00669 0.01015 65 0.12294 0.00805 0.00931 93 0.01377 1.72111 145.373 0.08736 0.23153
ytfE, scdA; regulator of cell morphogenesis and NO signaling 0.13254 0.00692 0.14422 0.00665 0.01012 65 0.12437 0.00813 0.00935 93 0.01377 1.44108 145.927 0.15171 0.27622
thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3] 0.13190 0.00902 0.15123 0.01255 0.01390 65 0.11839 0.01275 0.01171 93 0.01817 1.80706 138.566 0.07292 0.23153
E2.7.1.4, scrK; fructokinase [EC:2.7.1.4] 0.12970 0.00684 0.13858 0.00650 0.01000 65 0.12349 0.00800 0.00928 93 0.01364 1.10613 146.186 0.27049 0.40626
E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] 0.12896 0.00678 0.14334 0.00652 0.01001 65 0.11891 0.00760 0.00904 93 0.01349 1.81119 144.221 0.07219 0.23153
acpP; acyl carrier protein 0.12803 0.00773 0.13091 0.00757 0.01079 65 0.12603 0.01083 0.01079 93 0.01526 0.31966 150.965 0.74967 0.80755
SIAE; sialate O-acetylesterase [EC:3.1.1.53] 0.12799 0.00784 0.13305 0.00827 0.01128 65 0.12444 0.01080 0.01078 93 0.01560 0.55163 148.240 0.58203 0.67874
mrdA; penicillin-binding protein 2 [EC:3.4.16.4] 0.12744 0.00675 0.14141 0.00642 0.00994 65 0.11769 0.00759 0.00903 93 0.01343 1.76618 144.744 0.07947 0.23153
aspB; aspartate aminotransferase [EC:2.6.1.1] 0.12739 0.00725 0.13708 0.00745 0.01070 65 0.12062 0.00887 0.00976 93 0.01449 1.13640 144.989 0.25767 0.39294
nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6] 0.12621 0.00719 0.13684 0.00735 0.01064 65 0.11878 0.00871 0.00968 93 0.01438 1.25651 144.779 0.21095 0.34310
pepO; putative endopeptidase [EC:3.4.24.-] 0.12601 0.00672 0.13943 0.00639 0.00992 65 0.11663 0.00752 0.00899 93 0.01339 1.70274 144.534 0.09077 0.23153
pflA, pflC, pflE; pyruvate formate lyase activating enzyme [EC:1.97.1.4] 0.12586 0.00675 0.13781 0.00629 0.00984 65 0.11751 0.00772 0.00911 93 0.01341 1.51356 146.090 0.13230 0.25033
LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4] 0.12391 0.00658 0.13402 0.00595 0.00957 65 0.11685 0.00740 0.00892 93 0.01308 1.31236 146.576 0.19145 0.31853
moxR; MoxR-like ATPase [EC:3.6.3.-] 0.12123 0.00651 0.13528 0.00607 0.00967 65 0.11141 0.00698 0.00866 93 0.01298 1.83939 143.632 0.06792 0.23153
glnA, GLUL; glutamine synthetase [EC:6.3.1.2] 0.11923 0.00637 0.12997 0.00577 0.00942 65 0.11172 0.00679 0.00854 93 0.01272 1.43497 144.545 0.15346 0.27772
UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27] 0.11616 0.00631 0.12651 0.00560 0.00928 65 0.10893 0.00671 0.00849 93 0.01258 1.39727 145.199 0.16446 0.29098
E1.4.1.4, gdhA; glutamate dehydrogenase (NADP+) [EC:1.4.1.4] 0.11393 0.00624 0.12555 0.00557 0.00926 65 0.10581 0.00646 0.00833 93 0.01246 1.58497 143.959 0.11517 0.23153
ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-] 0.11132 0.00657 0.11410 0.00541 0.00912 65 0.10938 0.00788 0.00920 93 0.01296 0.36449 151.447 0.71600 0.79489
bglX; beta-glucosidase [EC:3.2.1.21] 0.10935 0.01120 0.10421 0.01668 0.01602 65 0.11295 0.02219 0.01545 93 0.02225 -0.39300 148.820 0.69488 0.77746
K06871; uncharacterized protein 0.10934 0.00636 0.11961 0.00568 0.00934 65 0.10217 0.00685 0.00858 93 0.01269 1.37403 145.471 0.17155 0.29378
thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7] 0.10715 0.00606 0.12010 0.00549 0.00919 65 0.09811 0.00587 0.00794 93 0.01215 1.81089 140.712 0.07229 0.23153
licD; lipopolysaccharide cholinephosphotransferase [EC:2.7.8.-] 0.10596 0.00656 0.12092 0.00700 0.01038 65 0.09551 0.00647 0.00834 93 0.01332 1.90842 134.407 0.05847 0.23153
cysE; serine O-acetyltransferase [EC:2.3.1.30] 0.10445 0.00608 0.11476 0.00537 0.00909 65 0.09724 0.00609 0.00810 93 0.01217 1.43880 143.155 0.15239 0.27669
hsdM; type I restriction enzyme M protein [EC:2.1.1.72] 0.10290 0.00634 0.10801 0.00611 0.00970 65 0.09933 0.00655 0.00839 93 0.01282 0.67637 140.781 0.49992 0.60634
fucP; MFS transporter, FHS family, L-fucose permease 0.10287 0.00589 0.11110 0.00499 0.00876 65 0.09713 0.00579 0.00789 93 0.01179 1.18452 143.987 0.23816 0.37248
lepB; signal peptidase I [EC:3.4.21.89] 0.10260 0.00631 0.11414 0.00659 0.01007 65 0.09453 0.00600 0.00803 93 0.01288 1.52265 133.734 0.13021 0.24759
fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] 0.10203 0.00555 0.10630 0.00390 0.00775 65 0.09905 0.00558 0.00775 93 0.01096 0.66141 150.968 0.50936 0.61377
K07481; transposase, IS5 family 0.10110 0.01066 0.11685 0.01857 0.01690 65 0.09009 0.01744 0.01369 93 0.02176 1.23014 135.088 0.22078 0.35460
PPIB, ppiB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8] 0.09968 0.00645 0.11106 0.00643 0.00995 65 0.09174 0.00659 0.00842 93 0.01303 1.48256 138.958 0.14046 0.26172
E3.2.1.22B, galA, rafA; alpha-galactosidase [EC:3.2.1.22] 0.09793 0.00637 0.10541 0.00580 0.00945 65 0.09271 0.00683 0.00857 93 0.01276 0.99593 144.582 0.32095 0.43751
E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2] 0.09734 0.00535 0.10760 0.00413 0.00797 65 0.09018 0.00472 0.00712 93 0.01069 1.63046 143.410 0.10520 0.23153
glk; glucokinase [EC:2.7.1.2] 0.09720 0.00545 0.10530 0.00433 0.00816 65 0.09154 0.00493 0.00728 93 0.01094 1.25810 143.236 0.21040 0.34268
bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] 0.09704 0.00534 0.10337 0.00382 0.00767 65 0.09261 0.00499 0.00733 93 0.01061 1.01429 148.250 0.31210 0.43751
E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1] 0.09574 0.00531 0.10398 0.00398 0.00783 65 0.08997 0.00476 0.00716 93 0.01061 1.32104 145.174 0.18857 0.31509
K07052; uncharacterized protein 0.09411 0.00537 0.09918 0.00338 0.00721 65 0.09057 0.00539 0.00761 93 0.01049 0.82141 153.503 0.41269 0.52981
dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-] 0.09066 0.00494 0.09753 0.00329 0.00711 65 0.08585 0.00425 0.00676 93 0.00981 1.19025 147.899 0.23586 0.37059
eptC; heptose-I-phosphate ethanolaminephosphotransferase [EC:2.7.8.-] 0.09023 0.00532 0.09842 0.00439 0.00822 65 0.08450 0.00450 0.00696 93 0.01077 1.29249 138.929 0.19833 0.32713
metY; O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49] 0.08978 0.00604 0.09373 0.00530 0.00903 65 0.08702 0.00614 0.00812 93 0.01215 0.55213 143.953 0.58171 0.67874
AMY, amyA, malS; alpha-amylase [EC:3.2.1.1] 0.08950 0.00511 0.09851 0.00354 0.00738 65 0.08321 0.00447 0.00693 93 0.01013 1.51141 147.067 0.13283 0.25092
wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14] 0.08918 0.00488 0.09590 0.00309 0.00689 65 0.08448 0.00423 0.00674 93 0.00964 1.18386 149.686 0.23835 0.37248
ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4] 0.08743 0.00476 0.09606 0.00321 0.00703 65 0.08140 0.00379 0.00639 93 0.00950 1.54357 144.669 0.12488 0.24217
phoN; acid phosphatase (class A) [EC:3.1.3.2] 0.08726 0.00673 0.09577 0.00697 0.01036 65 0.08131 0.00727 0.00884 93 0.01362 1.06142 139.659 0.29033 0.42619
ABC-2.OM, wza; polysaccharide biosynthesis/export protein 0.08720 0.00467 0.09312 0.00286 0.00664 65 0.08306 0.00385 0.00644 93 0.00925 1.08789 149.211 0.27840 0.41652
cpdB; 2’,3’-cyclic-nucleotide 2’-phosphodiesterase / 3’-nucleotidase [EC:3.1.4.16 3.1.3.6] 0.08720 0.00467 0.09312 0.00286 0.00664 65 0.08306 0.00385 0.00644 93 0.00925 1.08789 149.211 0.27840 0.41652
dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7] 0.08660 0.00468 0.09560 0.00327 0.00709 65 0.08031 0.00353 0.00616 93 0.00940 1.62662 141.095 0.10605 0.23153
radA, sms; DNA repair protein RadA/Sms 0.08629 0.00463 0.09201 0.00279 0.00655 65 0.08230 0.00379 0.00639 93 0.00915 1.06193 149.498 0.28998 0.42619
feoB; ferrous iron transport protein B 0.08485 0.00465 0.09302 0.00313 0.00694 65 0.07913 0.00357 0.00619 93 0.00930 1.49264 143.269 0.13773 0.25934
crcB, FEX; fluoride exporter 0.08436 0.00451 0.09162 0.00273 0.00648 65 0.07929 0.00353 0.00616 93 0.00894 1.37838 147.853 0.17017 0.29333
fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] 0.08420 0.00462 0.09470 0.00356 0.00740 65 0.07686 0.00315 0.00582 93 0.00941 1.89524 132.461 0.06024 0.23153
tatD; TatD DNase family protein [EC:3.1.21.-] 0.08418 0.00453 0.09197 0.00280 0.00657 65 0.07874 0.00351 0.00615 93 0.00899 1.47120 146.865 0.14338 0.26608
DHFR, folA; dihydrofolate reductase [EC:1.5.1.3] 0.08293 0.00450 0.09248 0.00311 0.00692 65 0.07625 0.00319 0.00586 93 0.00906 1.79056 139.000 0.07554 0.23153
fldA, nifF, isiB; flavodoxin I 0.08293 0.00450 0.09248 0.00311 0.00692 65 0.07625 0.00319 0.00586 93 0.00906 1.79056 139.000 0.07554 0.23153
GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16] 0.08293 0.00450 0.09248 0.00311 0.00692 65 0.07625 0.00319 0.00586 93 0.00906 1.79056 139.000 0.07554 0.23153
RP-L17, MRPL17, rplQ; large subunit ribosomal protein L17 0.08293 0.00450 0.09248 0.00311 0.00692 65 0.07625 0.00319 0.00586 93 0.00906 1.79056 139.000 0.07554 0.23153
zntA; Cd2+/Zn2+-exporting ATPase [EC:3.6.3.3 3.6.3.5] 0.08293 0.00450 0.09248 0.00311 0.00692 65 0.07625 0.00319 0.00586 93 0.00906 1.79056 139.000 0.07554 0.23153
metH, MTR; 5-methyltetrahydrofolate–homocysteine methyltransferase [EC:2.1.1.13] 0.08261 0.00568 0.08762 0.00507 0.00883 65 0.07911 0.00514 0.00743 93 0.01154 0.73721 138.453 0.46224 0.57956
mutT, NUDT15, MTH2; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] 0.08248 0.00589 0.08885 0.00542 0.00913 65 0.07802 0.00555 0.00773 93 0.01196 0.90534 138.949 0.36685 0.47947
copB; Cu2+-exporting ATPase [EC:3.6.3.4] 0.08239 0.00438 0.09028 0.00263 0.00636 65 0.07688 0.00327 0.00593 93 0.00870 1.54205 146.519 0.12522 0.24217
gltD; glutamate synthase (NADPH/NADH) small chain [EC:1.4.1.13 1.4.1.14] 0.08151 0.00481 0.08532 0.00315 0.00696 65 0.07884 0.00403 0.00658 93 0.00958 0.67693 147.598 0.49951 0.60634
lemA; LemA protein 0.08107 0.00440 0.08803 0.00273 0.00648 65 0.07620 0.00327 0.00593 93 0.00878 1.34563 145.243 0.18052 0.30472
vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22] 0.08105 0.00458 0.08949 0.00333 0.00715 65 0.07515 0.00325 0.00591 93 0.00928 1.54530 136.792 0.12458 0.24217
K07005; uncharacterized protein 0.08083 0.00439 0.08854 0.00285 0.00662 65 0.07544 0.00315 0.00582 93 0.00881 1.48603 141.999 0.13949 0.26095
TPI, tpiA; triosephosphate isomerase (TIM) [EC:5.3.1.1] 0.08022 0.00416 0.08825 0.00250 0.00620 65 0.07461 0.00286 0.00554 93 0.00832 1.64017 143.509 0.10316 0.23153
kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38] 0.08017 0.00416 0.08799 0.00247 0.00616 65 0.07471 0.00289 0.00557 93 0.00831 1.59919 144.310 0.11197 0.23153
metK; S-adenosylmethionine synthetase [EC:2.5.1.6] 0.08017 0.00416 0.08799 0.00247 0.00616 65 0.07471 0.00289 0.00557 93 0.00831 1.59919 144.310 0.11197 0.23153
fic; cell filamentation protein 0.08011 0.00422 0.08937 0.00272 0.00647 65 0.07364 0.00280 0.00549 93 0.00848 1.85444 139.105 0.06579 0.23153
K07085; putative transport protein 0.07896 0.00411 0.08635 0.00235 0.00601 65 0.07380 0.00286 0.00555 93 0.00818 1.53440 145.873 0.12710 0.24448
IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5] 0.07879 0.00410 0.08711 0.00248 0.00617 65 0.07297 0.00272 0.00540 93 0.00820 1.72409 141.759 0.08687 0.23153
lon; ATP-dependent Lon protease [EC:3.4.21.53] 0.07879 0.00410 0.08711 0.00248 0.00617 65 0.07297 0.00272 0.00540 93 0.00820 1.72409 141.759 0.08687 0.23153
purL, PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3] 0.07879 0.00410 0.08711 0.00248 0.00617 65 0.07297 0.00272 0.00540 93 0.00820 1.72409 141.759 0.08687 0.23153
rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] 0.07879 0.00410 0.08711 0.00248 0.00617 65 0.07297 0.00272 0.00540 93 0.00820 1.72409 141.759 0.08687 0.23153
URA4, pyrC; dihydroorotase [EC:3.5.2.3] 0.07879 0.00410 0.08711 0.00248 0.00617 65 0.07297 0.00272 0.00540 93 0.00820 1.72409 141.759 0.08687 0.23153
uup; ABC transport system ATP-binding/permease protein 0.07879 0.00410 0.08711 0.00248 0.00617 65 0.07297 0.00272 0.00540 93 0.00820 1.72409 141.759 0.08687 0.23153
K07011; uncharacterized protein 0.07855 0.00402 0.08432 0.00203 0.00559 65 0.07451 0.00290 0.00558 93 0.00790 1.24135 150.863 0.21640 0.34980
aspA; aspartate ammonia-lyase [EC:4.3.1.1] 0.07837 0.00437 0.08545 0.00241 0.00609 65 0.07341 0.00342 0.00606 93 0.00859 1.40148 150.772 0.16313 0.29017
rluA; tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29] 0.07806 0.00419 0.08564 0.00255 0.00626 65 0.07275 0.00288 0.00557 93 0.00838 1.53891 143.067 0.12604 0.24325
hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1] 0.07791 0.00632 0.08606 0.00621 0.00978 65 0.07221 0.00637 0.00827 93 0.01281 1.08059 138.933 0.28175 0.41851
comM; magnesium chelatase family protein 0.07770 0.00396 0.08360 0.00198 0.00552 65 0.07358 0.00282 0.00550 93 0.00779 1.28489 150.846 0.20080 0.32937
ftsZ; cell division protein FtsZ 0.07769 0.00397 0.08480 0.00214 0.00574 65 0.07272 0.00269 0.00538 93 0.00787 1.53550 146.945 0.12681 0.24434
E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1] 0.07754 0.00392 0.08489 0.00213 0.00573 65 0.07240 0.00260 0.00529 93 0.00779 1.60224 145.811 0.11127 0.23153
ATPF1A, atpA; F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14] 0.07752 0.00395 0.08314 0.00195 0.00547 65 0.07358 0.00282 0.00550 93 0.00776 1.23170 151.281 0.21997 0.35428
rsmI; 16S rRNA (cytidine1402-2’-O)-methyltransferase [EC:2.1.1.198] 0.07751 0.00396 0.08435 0.00211 0.00570 65 0.07272 0.00269 0.00538 93 0.00784 1.48355 147.441 0.14006 0.26160
carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5] 0.07681 0.00384 0.08423 0.00203 0.00558 65 0.07163 0.00249 0.00518 93 0.00762 1.65445 146.205 0.10018 0.23153
kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45] 0.07663 0.00382 0.08378 0.00200 0.00554 65 0.07163 0.00249 0.00518 93 0.00758 1.60156 146.755 0.11140 0.23153
ssb; single-strand DNA-binding protein 0.07663 0.00382 0.08378 0.00200 0.00554 65 0.07163 0.00249 0.00518 93 0.00758 1.60156 146.755 0.11140 0.23153
greA; transcription elongation factor GreA 0.07649 0.00383 0.08312 0.00195 0.00547 65 0.07186 0.00254 0.00523 93 0.00757 1.48674 148.262 0.13921 0.26085
purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14] 0.07643 0.00381 0.08352 0.00198 0.00551 65 0.07148 0.00249 0.00517 93 0.00756 1.59413 146.988 0.11306 0.23153
UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22] 0.07643 0.00381 0.08352 0.00198 0.00551 65 0.07148 0.00249 0.00517 93 0.00756 1.59413 146.988 0.11306 0.23153
hemD, UROS; uroporphyrinogen-III synthase [EC:4.2.1.75] 0.07631 0.00382 0.08266 0.00192 0.00543 65 0.07186 0.00254 0.00523 93 0.00754 1.43307 148.798 0.15394 0.27809
K09155; uncharacterized protein 0.07614 0.00384 0.08366 0.00212 0.00571 65 0.07088 0.00243 0.00511 93 0.00766 1.66767 143.501 0.09756 0.23153
yjbB; phosphate:Na+ symporter 0.07590 0.00378 0.08312 0.00195 0.00547 65 0.07086 0.00243 0.00511 93 0.00749 1.63742 146.633 0.10369 0.23153
ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25] 0.07573 0.00376 0.08266 0.00192 0.00543 65 0.07089 0.00243 0.00511 93 0.00745 1.57980 147.242 0.11630 0.23300
AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ABC.FEV.A; iron complex transport system ATP-binding protein [EC:3.6.3.34] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ABC.FEV.P; iron complex transport system permease protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ABC.FEV.S; iron complex transport system substrate-binding protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ABC.SN.S; NitT/TauT family transport system substrate-binding protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ABCF3; ATP-binding cassette, subfamily F, member 3 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ackA; acetate kinase [EC:2.7.2.1] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
adk, AK; adenylate kinase [EC:2.7.4.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
aguB; N-carbamoylputrescine amidase [EC:3.5.1.53] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
AIBP, nnrE; NAD(P)H-hydrate epimerase [EC:5.1.99.6] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
alr; alanine racemase [EC:5.1.1.1] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
apbE; FAD:protein FMN transferase [EC:2.7.1.180] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
APRT, apt; adenine phosphoribosyltransferase [EC:2.4.2.7] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
argR, ahrC; transcriptional regulator of arginine metabolism 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
AROA1, aroA; chorismate mutase [EC:5.4.99.5] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
aroB; 3-dehydroquinate synthase [EC:4.2.3.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
aroC; chorismate synthase [EC:4.2.3.5] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
aroE; shikimate dehydrogenase [EC:1.1.1.25] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
aspS; aspartyl-tRNA synthetase [EC:6.1.1.12] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ATPF0A, atpB; F-type H+-transporting ATPase subunit a 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ATPF0B, atpF; F-type H+-transporting ATPase subunit b 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ATPF0C, atpE; F-type H+-transporting ATPase subunit c 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ATPF1B, atpD; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ATPF1D, atpH; F-type H+-transporting ATPase subunit delta 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ATPF1E, atpC; F-type H+-transporting ATPase subunit epsilon 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ATPF1G, atpG; F-type H+-transporting ATPase subunit gamma 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
bamD; outer membrane protein assembly factor BamD 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
BCP, PRXQ, DOT5; peroxiredoxin Q/BCP [EC:1.11.1.15] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
birA; BirA family transcriptional regulator, biotin operon repressor / biotin—[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
cdd, CDA; cytidine deaminase [EC:3.5.4.5] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
CHO1, pssA; CDP-diacylglycerol—serine O-phosphatidyltransferase [EC:2.7.8.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
clpB; ATP-dependent Clp protease ATP-binding subunit ClpB 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
clpC; ATP-dependent Clp protease ATP-binding subunit ClpC 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
clpX, CLPX; ATP-dependent Clp protease ATP-binding subunit ClpX 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
cmk; CMP/dCMP kinase [EC:2.7.4.25] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
comEB; dCMP deaminase [EC:3.5.4.12] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
comEC; competence protein ComEC 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
corA; magnesium transporter 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
cydA; cytochrome bd ubiquinol oxidase subunit I [EC:1.10.3.14] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
cydB; cytochrome bd ubiquinol oxidase subunit II [EC:1.10.3.14] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
deaD, cshA; ATP-dependent RNA helicase DeaD [EC:3.6.4.13] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
deoC, DERA; deoxyribose-phosphate aldolase [EC:4.1.2.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dgt; dGTPase [EC:3.1.5.1] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dinB; DNA polymerase IV [EC:2.7.7.7] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dnaA; chromosomal replication initiator protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dnaB; replicative DNA helicase [EC:3.6.4.12] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dnaG; DNA primase [EC:2.7.7.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dnaJ; molecular chaperone DnaJ 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dnaK, HSPA9; molecular chaperone DnaK 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
DPP3; dipeptidyl-peptidase III [EC:3.4.14.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dsbD; thiol:disulfide interchange protein DsbD [EC:1.8.1.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dtd, DTD1; D-tyrosyl-tRNA(Tyr) deacylase [EC:3.1.-.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
dxr; 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E1.1.1.40, maeB; malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E2.3.1.8, pta; phosphate acetyltransferase [EC:2.3.1.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E2.7.1.71, aroK, aroL; shikimate kinase [EC:2.7.1.71] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E2.7.4.8, gmk; guanylate kinase [EC:2.7.4.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E2.7.7.24, rfbA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E2.7.7.3A, coaD, kdtB; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E3.2.1.1A; alpha-amylase [EC:3.2.1.1] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E3.6.1.22, NUDT12, nudC; NAD+ diphosphatase [EC:3.6.1.22] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E4.1.1.49, pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E4.2.1.2A, fumA, fumB; fumarate hydratase, class I [EC:4.2.1.2] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E4.2.1.46, rfbB, rffG; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E4.3.1.17, sdaA, sdaB, tdcG; L-serine dehydratase [EC:4.3.1.17] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E6.3.5.1, NADSYN1, QNS1, nadE; NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
efp; elongation factor P 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
engA, der; GTPase 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
engB; GTP-binding protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ENO, eno; enolase [EC:4.2.1.11] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
entC; isochorismate synthase [EC:5.4.4.2] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
era, ERAL1; GTPase 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
fbp3; fructose-1,6-bisphosphatase III [EC:3.1.3.11] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
fixA, etfB; electron transfer flavoprotein beta subunit 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
fixB, etfA; electron transfer flavoprotein alpha subunit 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:4.1.2.25 5.1.99.8 1.13.11.81] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
folP; dihydropteroate synthase [EC:2.5.1.15] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
frr, MRRF, RRF; ribosome recycling factor 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ftsA; cell division protein FtsA 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ftsE; cell division transport system ATP-binding protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ftsH, hflB; cell division protease FtsH [EC:3.4.24.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ftsK, spoIIIE; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ftsQ; cell division protein FtsQ 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ftsW, spoVE; cell division protein FtsW 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ftsX; cell division transport system permease protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ftsY; fused signal recognition particle receptor 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
galE, GALE; UDP-glucose 4-epimerase [EC:5.1.3.2] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
GARS, glyS1; glycyl-tRNA synthetase [EC:6.1.1.14] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
GBE1, glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
gcpE, ispG; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
gidA, mnmG, MTO1; tRNA uridine 5-carboxymethylaminomethyl modification enzyme 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
glgA; starch synthase [EC:2.4.1.21] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
gmd, GMDS; GDPmannose 4,6-dehydratase [EC:4.2.1.47] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
GPI, pgi; glucose-6-phosphate isomerase [EC:5.3.1.9] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
groEL, HSPD1; chaperonin GroEL 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
groES, HSPE1; chaperonin GroES 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
GRPE; molecular chaperone GrpE 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
gyrA; DNA gyrase subunit A [EC:5.99.1.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
gyrB; DNA gyrase subunit B [EC:5.99.1.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
hemK, prmC, HEMK; release factor glutamine methyltransferase [EC:2.1.1.297] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
hflX; GTPase 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
HINT1, hinT, hit; histidine triad (HIT) family protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
holA; DNA polymerase III subunit delta [EC:2.7.7.7] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
holB; DNA polymerase III subunit delta’ [EC:2.7.7.7] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
hprA; glycerate dehydrogenase [EC:1.1.1.29] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
hslR; ribosome-associated heat shock protein Hsp15 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
HSP90A, htpG; molecular chaperone HtpG 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
infA; translation initiation factor IF-1 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
infB, MTIF2; translation initiation factor IF-2 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
infC, MTIF3; translation initiation factor IF-3 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ispB; octaprenyl-diphosphate synthase [EC:2.5.1.90] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ispH, lytB; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
K00243; uncharacterized protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
K06890; uncharacterized protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
K07027; glycosyltransferase 2 family protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
K07037; uncharacterized protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
K07082; UPF0755 protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
K07137; uncharacterized protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
K07164; uncharacterized protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
K09861; uncharacterized protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
KAE1, tsaD, QRI7; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
kdsD, kpsF; arabinose-5-phosphate isomerase [EC:5.3.1.13] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
kdtA, waaA; 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.4.99.12 2.4.99.13 2.4.99.14 2.4.99.15] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
korC, oorC; 2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
korD, oorD; 2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
lepA; GTP-binding protein LepA 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
lolD; lipoprotein-releasing system ATP-binding protein [EC:3.6.3.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
lptB; lipopolysaccharide export system ATP-binding protein [EC:3.6.3.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
lptF; lipopolysaccharide export system permease protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
lptG; lipopolysaccharide export system permease protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
lpxC-fabZ; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
lpxH; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
lpxK; tetraacyldisaccharide 4’-kinase [EC:2.7.1.130] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
lpxL, htrB; Kdo2-lipid IVA lauroyltransferase [EC:2.3.1.241] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
lspA; signal peptidase II [EC:3.4.23.36] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
lysC; aspartate kinase [EC:2.7.2.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
maf; septum formation protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
malQ; 4-alpha-glucanotransferase [EC:2.4.1.25] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
manA, MPI; mannose-6-phosphate isomerase [EC:5.3.1.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
manB; phosphomannomutase [EC:5.4.2.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mdh; malate dehydrogenase [EC:1.1.1.37] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
menA; 1,4-dihydroxy-2-naphthoate octaprenyltransferase [EC:2.5.1.74 2.5.1.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
menB; naphthoate synthase [EC:4.1.3.36] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
menD; 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [EC:2.2.1.9] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mfd; transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mlaD, linM; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mlaE, linK; phospholipid/cholesterol/gamma-HCH transport system permease protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mlaF, linL, mkl; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mnmA, trmU; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
motB; chemotaxis protein MotB 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mraW, rsmH; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mreB; rod shape-determining protein MreB and related proteins 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mreC; rod shape-determining protein MreC 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mrp, NUBPL; ATP-binding protein involved in chromosome partitioning 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:3.6.3.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mscL; large conductance mechanosensitive channel 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mtgA; monofunctional glycosyltransferase [EC:2.4.1.129] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mtnN, mtn, pfs; adenosylhomocysteine nucleosidase [EC:3.2.2.9] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
murC; UDP-N-acetylmuramate–alanine ligase [EC:6.3.2.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
murD; UDP-N-acetylmuramoylalanine–D-glutamate ligase [EC:6.3.2.9] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase [EC:6.3.2.13] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
murF; UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase [EC:6.3.2.10] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
murG; UDP-N-acetylglucosamine–N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
murI; glutamate racemase [EC:5.1.1.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mutL; DNA mismatch repair protein MutL 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mutS; DNA mismatch repair protein MutS 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mutS2; DNA mismatch repair protein MutS2 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nfrA2; FMN reductase [NAD(P)H] [EC:1.5.1.39] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nqrA; Na+-transporting NADH:ubiquinone oxidoreductase subunit A [EC:1.6.5.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nqrB; Na+-transporting NADH:ubiquinone oxidoreductase subunit B [EC:1.6.5.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nqrC; Na+-transporting NADH:ubiquinone oxidoreductase subunit C [EC:1.6.5.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nqrD; Na+-transporting NADH:ubiquinone oxidoreductase subunit D [EC:1.6.5.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nqrE; Na+-transporting NADH:ubiquinone oxidoreductase subunit E [EC:1.6.5.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nqrF; Na+-transporting NADH:ubiquinone oxidoreductase subunit F [EC:1.6.5.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nspC; carboxynorspermidine decarboxylase [EC:4.1.1.96] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
NTH; endonuclease III [EC:4.2.99.18] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nuoA; NADH-quinone oxidoreductase subunit A [EC:1.6.5.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nuoB; NADH-quinone oxidoreductase subunit B [EC:1.6.5.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nuoCD; NADH-quinone oxidoreductase subunit C/D [EC:1.6.5.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nuoH; NADH-quinone oxidoreductase subunit H [EC:1.6.5.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nuoI; NADH-quinone oxidoreductase subunit I [EC:1.6.5.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nuoJ; NADH-quinone oxidoreductase subunit J [EC:1.6.5.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nuoK; NADH-quinone oxidoreductase subunit K [EC:1.6.5.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nuoL; NADH-quinone oxidoreductase subunit L [EC:1.6.5.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nuoM; NADH-quinone oxidoreductase subunit M [EC:1.6.5.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nuoN; NADH-quinone oxidoreductase subunit N [EC:1.6.5.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nupG; MFS transporter, NHS family, nucleoside permease 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nusA; N utilization substance protein A 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nusB; N utilization substance protein B 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
nusG; transcriptional antiterminator NusG 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
obgE, cgtA; GTPase [EC:3.6.5.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
parB, spo0J; chromosome partitioning protein, ParB family 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
parC; topoisomerase IV subunit A [EC:5.99.1.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
parE; topoisomerase IV subunit B [EC:5.99.1.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
PDF, def; peptide deformylase [EC:3.5.1.88] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pdxA; 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pepT; tripeptide aminopeptidase [EC:3.4.11.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pfp, PFP; diphosphate-dependent phosphofructokinase [EC:2.7.1.90] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pgm; phosphoglucomutase [EC:5.4.2.2] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
phnP; phosphoribosyl 1,2-cyclic phosphate phosphodiesterase [EC:3.1.4.55] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
phoH, phoL; phosphate starvation-inducible protein PhoH and related proteins 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
PK, pyk; pyruvate kinase [EC:2.7.1.40] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pnuC; nicotinamide mononucleotide transporter 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
polA; DNA polymerase I [EC:2.7.7.7] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
por, nifJ; pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ppnK, NADK; NAD+ kinase [EC:2.7.1.23] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
prfA, MTRF1, MRF1; peptide chain release factor 1 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
prfB; peptide chain release factor 2 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
prfC; peptide chain release factor 3 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
priA; primosomal protein N’ (replication factor Y) (superfamily II helicase) [EC:3.6.4.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pstS; phosphate transport system substrate-binding protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
PTH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
punA, PNP; purine-nucleoside phosphorylase [EC:2.4.2.1] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
purB, ADSL; adenylosuccinate lyase [EC:4.3.2.2] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
purD; phosphoribosylamine—glycine ligase [EC:6.3.4.13] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pycB; pyruvate carboxylase subunit B [EC:6.4.1.1] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
PYG, glgP; glycogen phosphorylase [EC:2.4.1.1] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pyrB, PYR2; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pyrDII; dihydroorotate dehydrogenase electron transfer subunit 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pyrF; orotidine-5’-phosphate decarboxylase [EC:4.1.1.23] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pyrG, CTPS; CTP synthase [EC:6.3.4.2] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pyrH; uridylate kinase [EC:2.7.4.22] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pyrI; aspartate carbamoyltransferase regulatory subunit 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
QARS, glnS; glutaminyl-tRNA synthetase [EC:6.1.1.18] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
queG; epoxyqueuosine reductase [EC:1.17.99.6] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
radC; DNA repair protein RadC 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rbfA; ribosome-binding factor A 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
recA; recombination protein RecA 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
recF; DNA replication and repair protein RecF 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
recN; DNA repair protein RecN (Recombination protein N) 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
recO; DNA repair protein RecO (recombination protein O) 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
recR; recombination protein RecR 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
recX; regulatory protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rfbC, rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rfbD, rmlD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rho; transcription termination factor Rho 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ribE, RIB5; riboflavin synthase [EC:2.5.1.9] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ribH, RIB4; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ridA, tdcF, RIDA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rimM; 16S rRNA processing protein RimM 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rimP; ribosome maturation factor RimP 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rmuC; DNA recombination protein RmuC 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rng, cafA; ribonuclease G [EC:3.1.26.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rnhB; ribonuclease HII [EC:3.1.26.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rnpA; ribonuclease P protein component [EC:3.1.26.5] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rnr, vacB; ribonuclease R [EC:3.1.-.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rny; ribonucrease Y [EC:3.1.-.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rnz; ribonuclease Z [EC:3.1.26.11] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rodA, mrdB; rod shape determining protein RodA 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L1, MRPL1, rplA; large subunit ribosomal protein L1 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L10, MRPL10, rplJ; large subunit ribosomal protein L10 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L11, MRPL11, rplK; large subunit ribosomal protein L11 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L13, MRPL13, rplM; large subunit ribosomal protein L13 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L14, MRPL14, rplN; large subunit ribosomal protein L14 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L15, MRPL15, rplO; large subunit ribosomal protein L15 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L16, MRPL16, rplP; large subunit ribosomal protein L16 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L18, MRPL18, rplR; large subunit ribosomal protein L18 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L19, MRPL19, rplS; large subunit ribosomal protein L19 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L2, MRPL2, rplB; large subunit ribosomal protein L2 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L20, MRPL20, rplT; large subunit ribosomal protein L20 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L21, MRPL21, rplU; large subunit ribosomal protein L21 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L22, MRPL22, rplV; large subunit ribosomal protein L22 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L23, MRPL23, rplW; large subunit ribosomal protein L23 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L24, MRPL24, rplX; large subunit ribosomal protein L24 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L25, rplY; large subunit ribosomal protein L25 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L27, MRPL27, rpmA; large subunit ribosomal protein L27 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L28, MRPL28, rpmB; large subunit ribosomal protein L28 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L29, rpmC; large subunit ribosomal protein L29 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L3, MRPL3, rplC; large subunit ribosomal protein L3 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L30, MRPL30, rpmD; large subunit ribosomal protein L30 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L31, rpmE; large subunit ribosomal protein L31 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L32, MRPL32, rpmF; large subunit ribosomal protein L32 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L33, MRPL33, rpmG; large subunit ribosomal protein L33 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L35, MRPL35, rpmI; large subunit ribosomal protein L35 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L4, MRPL4, rplD; large subunit ribosomal protein L4 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L5, MRPL5, rplE; large subunit ribosomal protein L5 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L6, MRPL6, rplF; large subunit ribosomal protein L6 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L7, MRPL12, rplL; large subunit ribosomal protein L7/L12 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-L9, MRPL9, rplI; large subunit ribosomal protein L9 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S1, rpsA; small subunit ribosomal protein S1 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S10, MRPS10, rpsJ; small subunit ribosomal protein S10 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S11, MRPS11, rpsK; small subunit ribosomal protein S11 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S13, rpsM; small subunit ribosomal protein S13 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S14, MRPS14, rpsN; small subunit ribosomal protein S14 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S15, MRPS15, rpsO; small subunit ribosomal protein S15 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S16, MRPS16, rpsP; small subunit ribosomal protein S16 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S17, MRPS17, rpsQ; small subunit ribosomal protein S17 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S19, rpsS; small subunit ribosomal protein S19 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S20, rpsT; small subunit ribosomal protein S20 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S21, MRPS21, rpsU; small subunit ribosomal protein S21 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S3, rpsC; small subunit ribosomal protein S3 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S4, rpsD; small subunit ribosomal protein S4 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S5, MRPS5, rpsE; small subunit ribosomal protein S5 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S7, MRPS7, rpsG; small subunit ribosomal protein S7 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S8, rpsH; small subunit ribosomal protein S8 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
RP-S9, MRPS9, rpsI; small subunit ribosomal protein S9 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rpe, RPE; ribulose-phosphate 3-epimerase [EC:5.1.3.1] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rpoC; DNA-directed RNA polymerase subunit beta’ [EC:2.7.7.6] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rpoN; RNA polymerase sigma-54 factor 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rseP; regulator of sigma E protease [EC:3.4.24.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rtpR; ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ruvA; holliday junction DNA helicase RuvA [EC:3.6.4.12] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ruvB; holliday junction DNA helicase RuvB [EC:3.6.4.12] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ruvX; putative holliday junction resolvase [EC:3.1.-.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
SAM50, TOB55, bamA; outer membrane protein insertion porin family 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
sdhA, frdA; succinate dehydrogenase / fumarate reductase, flavoprotein subunit [EC:1.3.5.1 1.3.5.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
sdhB, frdB; succinate dehydrogenase / fumarate reductase, iron-sulfur subunit [EC:1.3.5.1 1.3.5.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
sdhC, frdC; succinate dehydrogenase / fumarate reductase, cytochrome b subunit 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
secA; preprotein translocase subunit SecA 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
secDF; SecD/SecF fusion protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
secG; preprotein translocase subunit SecG 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
secY; preprotein translocase subunit SecY 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
slyD; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
smf; DNA processing protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
smpB; SsrA-binding protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
speA; arginine decarboxylase [EC:4.1.1.19] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
speG, SAT; diamine N-acetyltransferase [EC:2.3.1.57] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
spoU; RNA methyltransferase, TrmH family 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
sppA; protease IV [EC:3.4.21.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
sufB; Fe-S cluster assembly protein SufB 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
sufC; Fe-S cluster assembly ATP-binding protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
sufD; Fe-S cluster assembly protein SufD 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
sufE; cysteine desulfuration protein SufE 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
surE; 5’-nucleotidase [EC:3.1.3.5] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
tadA; tRNA(adenine34) deaminase [EC:3.5.4.33] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
TC.CIC; chloride channel protein, CIC family 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
TC.POT; proton-dependent oligopeptide transporter, POT family 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
tdk, TK; thymidine kinase [EC:2.7.1.21] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
tgt, QTRT1; queuine tRNA-ribosyltransferase [EC:2.4.2.29] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
thiJ; protein deglycase [EC:3.5.1.124] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
thiL; thiamine-monophosphate kinase [EC:2.7.4.16] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
tig; trigger factor 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
topA; DNA topoisomerase I [EC:5.99.1.2] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
trkA, ktrA; trk system potassium uptake protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
trkH, trkG, ktrB; trk system potassium uptake protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
trmB, METTL1; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
truA, PUS1; tRNA pseudouridine38-40 synthase [EC:5.4.99.12] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
truB, PUS4, TRUB1; tRNA pseudouridine55 synthase [EC:5.4.99.25] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
trxA; thioredoxin 1 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
tsaC, rimN, SUA5; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
tsf, TSFM; elongation factor Ts 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
TSTA3, fcl; GDP-L-fucose synthase [EC:1.1.1.271] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
tuf, TUFM; elongation factor Tu 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
typA, bipA; GTP-binding protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
udp, UPP; uridine phosphorylase [EC:2.4.2.3] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
uvrB; excinuclease ABC subunit B 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
uvrC; excinuclease ABC subunit C 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
xerC; integrase/recombinase XerC 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
xerD; integrase/recombinase XerD 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
yajC; preprotein translocase subunit YajC 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ybeB; ribosome-associated protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ycaJ; putative ATPase 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ychF; ribosome-binding ATPase 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
yfiC, trmX; tRNA1Val (adenine37-N6)-methyltransferase [EC:2.1.1.223] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
yfiH; polyphenol oxidase [EC:1.10.3.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
yggS, PROSC; PLP dependent protein 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-] 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
yraN; putative endonuclease 0.07572 0.00376 0.08266 0.00192 0.00543 65 0.07086 0.00243 0.00511 93 0.00745 1.58388 147.213 0.11537 0.23153
pncB, NAPRT1; nicotinate phosphoribosyltransferase [EC:6.3.4.21] 0.07553 0.00376 0.08221 0.00191 0.00542 65 0.07086 0.00243 0.00511 93 0.00745 1.52421 147.312 0.12960 0.24692
PRDX2_4, ahpC; peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC:1.11.1.15] 0.07553 0.00376 0.08221 0.00191 0.00542 65 0.07086 0.00243 0.00511 93 0.00745 1.52421 147.312 0.12960 0.24692
TC.KEF; monovalent cation:H+ antiporter-2, CPA2 family 0.07549 0.00411 0.08552 0.00246 0.00615 65 0.06847 0.00272 0.00541 93 0.00819 2.08130 142.123 0.03920 0.23153
TC.BASS; bile acid:Na+ symporter, BASS family 0.07518 0.00377 0.08246 0.00199 0.00553 65 0.07009 0.00239 0.00507 93 0.00750 1.64899 145.418 0.10131 0.23153
coaBC, dfp; phosphopantothenoylcysteine decarboxylase / phosphopantothenate—cysteine ligase [EC:4.1.1.36 6.3.2.5] 0.07513 0.00376 0.08266 0.00192 0.00543 65 0.06986 0.00240 0.00508 93 0.00744 1.72184 146.905 0.08720 0.23153
panB; 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11] 0.07513 0.00376 0.08266 0.00192 0.00543 65 0.06986 0.00240 0.00508 93 0.00744 1.72184 146.905 0.08720 0.23153
panC; pantoate–beta-alanine ligase [EC:6.3.2.1] 0.07513 0.00376 0.08266 0.00192 0.00543 65 0.06986 0.00240 0.00508 93 0.00744 1.72184 146.905 0.08720 0.23153
panD; aspartate 1-decarboxylase [EC:4.1.1.11] 0.07513 0.00376 0.08266 0.00192 0.00543 65 0.06986 0.00240 0.00508 93 0.00744 1.72184 146.905 0.08720 0.23153
mltD, dniR; membrane-bound lytic murein transglycosylase D [EC:4.2.2.-] 0.07511 0.00378 0.08122 0.00198 0.00552 65 0.07084 0.00242 0.00511 93 0.00752 1.38064 146.048 0.16950 0.29333
oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator 0.07494 0.00375 0.08221 0.00191 0.00542 65 0.06986 0.00240 0.00508 93 0.00743 1.66216 147.005 0.09861 0.23153
dapdh; diaminopimelate dehydrogenase [EC:1.4.1.16] 0.07481 0.00374 0.08155 0.00189 0.00540 65 0.07009 0.00239 0.00507 93 0.00740 1.54797 147.134 0.12378 0.24171
K07139; uncharacterized protein 0.07481 0.00374 0.08155 0.00189 0.00540 65 0.07009 0.00239 0.00507 93 0.00740 1.54797 147.134 0.12378 0.24171
malY, malT; maltose/moltooligosaccharide transporter 0.07481 0.00374 0.08155 0.00189 0.00540 65 0.07009 0.00239 0.00507 93 0.00740 1.54797 147.134 0.12378 0.24171
RP-L34, MRPL34, rpmH; large subunit ribosomal protein L34 0.07481 0.00374 0.08155 0.00189 0.00540 65 0.07009 0.00239 0.00507 93 0.00740 1.54797 147.134 0.12378 0.24171
serA, PHGDH; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] 0.07481 0.00374 0.08155 0.00189 0.00540 65 0.07009 0.00239 0.00507 93 0.00740 1.54797 147.134 0.12378 0.24171
serC, PSAT1; phosphoserine aminotransferase [EC:2.6.1.52] 0.07481 0.00374 0.08155 0.00189 0.00540 65 0.07009 0.00239 0.00507 93 0.00740 1.54797 147.134 0.12378 0.24171
tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] 0.07460 0.00467 0.08256 0.00323 0.00705 65 0.06904 0.00356 0.00619 93 0.00938 1.44185 141.941 0.15155 0.27622
SLC13A2_3_5; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 0.07446 0.00379 0.08138 0.00195 0.00548 65 0.06961 0.00245 0.00514 93 0.00751 1.56780 147.001 0.11908 0.23734
E3.1.3.48; protein-tyrosine phosphatase [EC:3.1.3.48] 0.07439 0.00377 0.08041 0.00198 0.00552 65 0.07019 0.00242 0.00510 93 0.00752 1.35944 146.018 0.17610 0.29989
nrfA; nitrite reductase (cytochrome c-552) [EC:1.7.2.2] 0.07433 0.00377 0.08076 0.00197 0.00551 65 0.06984 0.00240 0.00508 93 0.00749 1.45792 145.849 0.14701 0.27108
nrfH; cytochrome c nitrite reductase small subunit 0.07433 0.00377 0.08076 0.00197 0.00551 65 0.06984 0.00240 0.00508 93 0.00749 1.45792 145.849 0.14701 0.27108
K07000; uncharacterized protein 0.07411 0.00376 0.08143 0.00195 0.00548 65 0.06900 0.00239 0.00507 93 0.00747 1.66499 146.036 0.09806 0.23153
coaW; type II pantothenate kinase [EC:2.7.1.33] 0.07393 0.00375 0.08098 0.00192 0.00543 65 0.06900 0.00239 0.00507 93 0.00743 1.61181 146.658 0.10915 0.23153
E3.1.3.5; 5’-nucleotidase [EC:3.1.3.5] 0.07393 0.00375 0.08098 0.00192 0.00543 65 0.06900 0.00239 0.00507 93 0.00743 1.61181 146.658 0.10915 0.23153
fabI; enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10] 0.07393 0.00375 0.08098 0.00192 0.00543 65 0.06900 0.00239 0.00507 93 0.00743 1.61181 146.658 0.10915 0.23153
ftnA, ftn; ferritin [EC:1.16.3.2] 0.07393 0.00375 0.08098 0.00192 0.00543 65 0.06900 0.00239 0.00507 93 0.00743 1.61181 146.658 0.10915 0.23153
K09125; uncharacterized protein 0.07393 0.00375 0.08098 0.00192 0.00543 65 0.06900 0.00239 0.00507 93 0.00743 1.61181 146.658 0.10915 0.23153
menE; O-succinylbenzoic acid—CoA ligase [EC:6.2.1.26] 0.07393 0.00375 0.08098 0.00192 0.00543 65 0.06900 0.00239 0.00507 93 0.00743 1.61181 146.658 0.10915 0.23153
pdxS, pdx1; pyridoxal 5’-phosphate synthase pdxS subunit [EC:4.3.3.6] 0.07393 0.00375 0.08098 0.00192 0.00543 65 0.06900 0.00239 0.00507 93 0.00743 1.61181 146.658 0.10915 0.23153
pdxT, pdx2; 5’-phosphate synthase pdxT subunit [EC:4.3.3.6] 0.07393 0.00375 0.08098 0.00192 0.00543 65 0.06900 0.00239 0.00507 93 0.00743 1.61181 146.658 0.10915 0.23153
trpF; phosphoribosylanthranilate isomerase [EC:5.3.1.24] 0.07393 0.00375 0.08098 0.00192 0.00543 65 0.06900 0.00239 0.00507 93 0.00743 1.61181 146.658 0.10915 0.23153
zapA; cell division protein ZapA 0.07393 0.00375 0.08098 0.00192 0.00543 65 0.06900 0.00239 0.00507 93 0.00743 1.61181 146.658 0.10915 0.23153
rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3] 0.07392 0.00380 0.08218 0.00190 0.00541 65 0.06814 0.00249 0.00517 93 0.00749 1.87655 148.240 0.06254 0.23153
hcp; hydroxylamine reductase [EC:1.7.99.1] 0.07386 0.00381 0.08112 0.00201 0.00557 65 0.06878 0.00245 0.00513 93 0.00757 1.63041 145.713 0.10517 0.23153
pbuG; putative MFS transporter, AGZA family, xanthine/uracil permease 0.07374 0.00374 0.08052 0.00191 0.00542 65 0.06900 0.00239 0.00507 93 0.00743 1.55234 146.787 0.12273 0.24171
rlpA; rare lipoprotein A 0.07373 0.00380 0.08173 0.00190 0.00540 65 0.06814 0.00249 0.00517 93 0.00748 1.81748 148.342 0.07116 0.23153
E2.3.1.54, pflD; formate C-acetyltransferase [EC:2.3.1.54] 0.07361 0.00374 0.08011 0.00195 0.00548 65 0.06907 0.00237 0.00504 93 0.00745 1.48171 145.657 0.14058 0.26172
ybdG, mscM; miniconductance mechanosensitive channel 0.07332 0.00376 0.07953 0.00198 0.00552 65 0.06898 0.00239 0.00507 93 0.00749 1.40871 145.558 0.16105 0.28737
K08999; uncharacterized protein 0.07302 0.00372 0.07987 0.00189 0.00540 65 0.06823 0.00235 0.00503 93 0.00738 1.57731 146.596 0.11688 0.23336
pyrP, uraA; uracil permease 0.07283 0.00371 0.07941 0.00188 0.00538 65 0.06823 0.00235 0.00503 93 0.00737 1.51760 146.746 0.13127 0.24919
K07007; uncharacterized protein 0.07260 0.00376 0.07872 0.00197 0.00551 65 0.06833 0.00239 0.00507 93 0.00749 1.38830 145.542 0.16717 0.29098
thyA, TYMS; thymidylate synthase [EC:2.1.1.45] 0.07143 0.00447 0.08038 0.00307 0.00687 65 0.06518 0.00315 0.00582 93 0.00900 1.68884 138.988 0.09349 0.23153
pdxK, pdxY; pyridoxine kinase [EC:2.7.1.35] 0.07141 0.00377 0.08043 0.00190 0.00541 65 0.06511 0.00241 0.00509 93 0.00743 2.06193 147.224 0.04097 0.23153
thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2] 0.07085 0.00383 0.07895 0.00200 0.00555 65 0.06519 0.00249 0.00517 93 0.00758 1.81463 146.567 0.07163 0.23153
galK; galactokinase [EC:2.7.1.6] 0.07068 0.00374 0.07689 0.00201 0.00556 65 0.06634 0.00232 0.00500 93 0.00747 1.41162 143.879 0.16022 0.28676
K08998; uncharacterized protein 0.07068 0.00374 0.07689 0.00201 0.00556 65 0.06634 0.00232 0.00500 93 0.00747 1.41162 143.879 0.16022 0.28676
dps; starvation-inducible DNA-binding protein 0.07047 0.00378 0.07544 0.00213 0.00572 65 0.06699 0.00234 0.00501 93 0.00761 1.11051 141.798 0.26866 0.40456
ppnN; pyrimidine/purine-5’-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-] 0.07030 0.00394 0.07454 0.00221 0.00583 65 0.06733 0.00262 0.00530 93 0.00788 0.91370 144.741 0.36239 0.47472
maa; maltose O-acetyltransferase [EC:2.3.1.79] 0.07021 0.00400 0.07670 0.00231 0.00596 65 0.06567 0.00266 0.00535 93 0.00801 1.37714 143.668 0.17061 0.29356
PPOX, hemY; protoporphyrinogen/coproporphyrinogen III oxidase [EC:1.3.3.4 1.3.3.15] 0.06982 0.00372 0.07575 0.00203 0.00559 65 0.06567 0.00227 0.00494 93 0.00746 1.35116 142.627 0.17878 0.30268
tex; protein Tex 0.06976 0.00369 0.07623 0.00195 0.00548 65 0.06524 0.00227 0.00494 93 0.00738 1.48917 144.137 0.13863 0.26029
fhs; formate–tetrahydrofolate ligase [EC:6.3.4.3] 0.06851 0.00372 0.07285 0.00198 0.00552 65 0.06547 0.00233 0.00500 93 0.00745 0.99027 144.500 0.32370 0.43751
luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21] 0.06851 0.00372 0.07285 0.00198 0.00552 65 0.06547 0.00233 0.00500 93 0.00745 0.99027 144.500 0.32370 0.43751
npdA; NAD-dependent deacetylase [EC:3.5.1.-] 0.06851 0.00372 0.07285 0.00198 0.00552 65 0.06547 0.00233 0.00500 93 0.00745 0.99027 144.500 0.32370 0.43751
yhbH; putative sigma-54 modulation protein 0.06851 0.00372 0.07285 0.00198 0.00552 65 0.06547 0.00233 0.00500 93 0.00745 0.99027 144.500 0.32370 0.43751
MMAB, pduO; cob(I)alamin adenosyltransferase [EC:2.5.1.17] 0.06832 0.00371 0.07240 0.00197 0.00550 65 0.06547 0.00233 0.00500 93 0.00744 0.93132 144.778 0.35324 0.46483
kbl, GCAT; glycine C-acetyltransferase [EC:2.3.1.29] 0.06804 0.00527 0.07143 0.00403 0.00787 65 0.06567 0.00467 0.00708 93 0.01059 0.54443 143.949 0.58699 0.68383
fruA; fructan beta-fructosidase [EC:3.2.1.80] 0.06790 0.00373 0.07140 0.00202 0.00557 65 0.06545 0.00233 0.00500 93 0.00749 0.79520 143.811 0.42781 0.54380
gpmB; probable phosphoglycerate mutase [EC:5.4.2.12] 0.06760 0.00368 0.07174 0.00194 0.00546 65 0.06470 0.00229 0.00496 93 0.00738 0.95419 144.676 0.34158 0.45143
mraZ; MraZ protein 0.06760 0.00368 0.07174 0.00194 0.00546 65 0.06470 0.00229 0.00496 93 0.00738 0.95419 144.676 0.34158 0.45143
HSP20; HSP20 family protein 0.06752 0.00372 0.07070 0.00201 0.00556 65 0.06530 0.00232 0.00500 93 0.00747 0.72254 143.952 0.47114 0.58301
cutC; copper homeostasis protein 0.06752 0.00370 0.07143 0.00195 0.00547 65 0.06478 0.00232 0.00499 93 0.00741 0.89787 144.940 0.37074 0.48293
glmS, GFPT; glucosamine—fructose-6-phosphate aminotransferase (isomerizing) [EC:2.6.1.16] 0.06719 0.00369 0.07219 0.00198 0.00552 65 0.06370 0.00226 0.00493 93 0.00740 1.14755 143.403 0.25306 0.38814
pulA; pullulanase [EC:3.2.1.41] 0.06672 0.00368 0.07116 0.00195 0.00548 65 0.06361 0.00228 0.00495 93 0.00738 1.02340 144.183 0.30783 0.43751
gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12] 0.06658 0.00373 0.07231 0.00196 0.00549 65 0.06258 0.00235 0.00503 93 0.00744 1.30606 145.315 0.19360 0.32026
secE; preprotein translocase subunit SecE 0.06616 0.00363 0.07260 0.00184 0.00531 65 0.06166 0.00223 0.00489 93 0.00722 1.51502 145.681 0.13193 0.25005
lldE; L-lactate dehydrogenase complex protein LldE 0.06613 0.00367 0.07116 0.00195 0.00548 65 0.06261 0.00225 0.00492 93 0.00736 1.16232 143.700 0.24703 0.38244
lldF; L-lactate dehydrogenase complex protein LldF 0.06613 0.00367 0.07116 0.00195 0.00548 65 0.06261 0.00225 0.00492 93 0.00736 1.16232 143.700 0.24703 0.38244
lldG; L-lactate dehydrogenase complex protein LldG 0.06613 0.00367 0.07116 0.00195 0.00548 65 0.06261 0.00225 0.00492 93 0.00736 1.16232 143.700 0.24703 0.38244
cbpA; curved DNA-binding protein 0.06612 0.00373 0.07237 0.00196 0.00549 65 0.06175 0.00233 0.00501 93 0.00743 1.42920 144.949 0.15510 0.27932
ina; immune inhibitor A [EC:3.4.24.-] 0.06611 0.00369 0.06972 0.00198 0.00552 65 0.06359 0.00227 0.00494 93 0.00741 0.82689 143.574 0.40967 0.52653
patB, malY; cystathione beta-lyase [EC:4.4.1.8] 0.06585 0.00370 0.06917 0.00198 0.00552 65 0.06353 0.00231 0.00498 93 0.00743 0.75842 144.231 0.44944 0.56632
nhaA; Na+:H+ antiporter, NhaA family 0.06571 0.00376 0.07038 0.00215 0.00575 65 0.06244 0.00229 0.00496 93 0.00759 1.04565 140.611 0.29752 0.43391
K06889; uncharacterized protein 0.06556 0.00394 0.06998 0.00219 0.00580 65 0.06247 0.00265 0.00534 93 0.00788 0.95356 145.626 0.34189 0.45143
trpB; tryptophan synthase beta chain [EC:4.2.1.20] 0.06447 0.00384 0.06911 0.00221 0.00583 65 0.06123 0.00242 0.00510 93 0.00774 1.01835 141.689 0.31025 0.43751
E3.6.3.8; Ca2+-transporting ATPase [EC:3.6.3.8] 0.06423 0.00370 0.07220 0.00194 0.00547 65 0.05865 0.00227 0.00494 93 0.00737 1.83853 144.268 0.06804 0.23153
xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22] 0.06423 0.00370 0.07220 0.00194 0.00547 65 0.05865 0.00227 0.00494 93 0.00737 1.83853 144.268 0.06804 0.23153
ATOX1, ATX1, copZ, golB; copper chaperone 0.06419 0.00370 0.06917 0.00195 0.00548 65 0.06070 0.00230 0.00497 93 0.00740 1.14483 144.481 0.25417 0.38933
hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9] 0.06404 0.00436 0.07216 0.00314 0.00695 65 0.05837 0.00286 0.00555 93 0.00890 1.55048 133.762 0.12339 0.24171
yrbG; cation:H+ antiporter 0.06404 0.00370 0.07175 0.00193 0.00545 65 0.05865 0.00227 0.00494 93 0.00735 1.78084 144.565 0.07704 0.23153
K07058; membrane protein 0.06402 0.00368 0.06991 0.00200 0.00555 65 0.05990 0.00221 0.00487 93 0.00739 1.35400 141.992 0.17789 0.30243
ogt, MGMT; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] 0.06378 0.00369 0.07122 0.00191 0.00542 65 0.05858 0.00227 0.00494 93 0.00733 1.72314 144.816 0.08700 0.23153
rnfG; electron transport complex protein RnfG 0.06360 0.00368 0.06917 0.00195 0.00548 65 0.05970 0.00226 0.00493 93 0.00737 1.28451 143.906 0.20103 0.32937
ndh; NADH dehydrogenase [EC:1.6.99.3] 0.06341 0.00362 0.06926 0.00188 0.00538 65 0.05932 0.00217 0.00483 93 0.00724 1.37484 143.778 0.17132 0.29378
PREP; prolyl oligopeptidase [EC:3.4.21.26] 0.06292 0.00371 0.06907 0.00199 0.00553 65 0.05861 0.00228 0.00495 93 0.00742 1.40935 143.563 0.16089 0.28737
TC.AGCS; alanine or glycine:cation symporter, AGCS family 0.06189 0.00589 0.06763 0.00533 0.00906 65 0.05788 0.00562 0.00777 93 0.01194 0.81760 140.104 0.41498 0.53216
K09704; uncharacterized protein 0.06151 0.00357 0.06674 0.00184 0.00532 65 0.05786 0.00212 0.00478 93 0.00715 1.24111 143.737 0.21659 0.34980
purT; phosphoribosylglycinamide formyltransferase 2 [EC:2.1.2.2] 0.06149 0.00363 0.06872 0.00186 0.00535 65 0.05643 0.00220 0.00487 93 0.00723 1.69875 144.763 0.09151 0.23153
mp2; beta-1,4-mannooligosaccharide/beta-1,4-mannosyl-N-acetylglucosamine phosphorylase [EC:2.4.1.319 2.4.1.320] 0.06122 0.00359 0.06616 0.00181 0.00528 65 0.05777 0.00219 0.00485 93 0.00717 1.17120 145.487 0.24343 0.37889
NEU1; sialidase-1 [EC:3.2.1.18] 0.06122 0.00359 0.06616 0.00181 0.00528 65 0.05777 0.00219 0.00485 93 0.00717 1.17120 145.487 0.24343 0.37889
serB, PSPH; phosphoserine phosphatase [EC:3.1.3.3] 0.06103 0.00358 0.06379 0.00196 0.00549 65 0.05911 0.00208 0.00473 93 0.00725 0.64545 140.417 0.51969 0.62363
xanP; xanthine permease XanP 0.06072 0.00367 0.06799 0.00195 0.00547 65 0.05564 0.00221 0.00488 93 0.00733 1.68468 143.230 0.09423 0.23153
RENBP; N-acylglucosamine 2-epimerase [EC:5.1.3.8] 0.06061 0.00359 0.06471 0.00183 0.00530 65 0.05775 0.00219 0.00485 93 0.00718 0.96980 145.221 0.33376 0.44424
pncA; nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-] 0.05948 0.00367 0.06899 0.00187 0.00536 65 0.05283 0.00223 0.00490 93 0.00726 2.22516 145.193 0.02761 0.23153
glxK, garK; glycerate 2-kinase [EC:2.7.1.165] 0.05947 0.00361 0.06439 0.00191 0.00543 65 0.05602 0.00215 0.00481 93 0.00725 1.15429 142.745 0.25031 0.38443
lipA; lipoyl synthase [EC:2.8.1.8] 0.05908 0.00388 0.06195 0.00204 0.00560 65 0.05708 0.00263 0.00532 93 0.00772 0.63050 147.835 0.52934 0.63324
K07001; NTE family protein 0.05894 0.00398 0.06157 0.00243 0.00612 65 0.05710 0.00258 0.00527 93 0.00807 0.55357 140.364 0.58075 0.67862
asnA; aspartate–ammonia ligase [EC:6.3.1.1] 0.05864 0.00350 0.06283 0.00179 0.00525 65 0.05570 0.00204 0.00468 93 0.00703 1.01338 143.230 0.31259 0.43751
E4.1.3.3, nanA, NPL; N-acetylneuraminate lyase [EC:4.1.3.3] 0.05861 0.00359 0.06311 0.00187 0.00536 65 0.05548 0.00214 0.00480 93 0.00720 1.06037 143.648 0.29075 0.42619
RP-L36, MRPL36, rpmJ; large subunit ribosomal protein L36 0.05850 0.00370 0.06554 0.00201 0.00556 65 0.05358 0.00223 0.00490 93 0.00741 1.61328 142.268 0.10890 0.23153
ahpF; alkyl hydroperoxide reductase subunit F [EC:1.6.4.-] 0.05754 0.00363 0.06421 0.00193 0.00544 65 0.05287 0.00216 0.00482 93 0.00727 1.55924 142.686 0.12116 0.24065
oprO_P; phosphate-selective porin OprO and OprP 0.05743 0.00360 0.06410 0.00183 0.00531 65 0.05277 0.00217 0.00483 93 0.00718 1.57768 144.747 0.11682 0.23336
AXY8, FUC95A, afcA; alpha-L-fucosidase 2 [EC:3.2.1.51] 0.05734 0.00363 0.06331 0.00200 0.00555 65 0.05316 0.00211 0.00476 93 0.00731 1.38904 140.221 0.16702 0.29098
perR; Fur family transcriptional regulator, peroxide stress response regulator 0.05702 0.00362 0.06239 0.00202 0.00558 65 0.05327 0.00210 0.00475 93 0.00733 1.24513 139.394 0.21517 0.34849
K06885; uncharacterized protein 0.05694 0.00366 0.06394 0.00198 0.00552 65 0.05204 0.00218 0.00484 93 0.00734 1.62213 141.886 0.10699 0.23153
lysA; diaminopimelate decarboxylase [EC:4.1.1.20] 0.05679 0.00359 0.05945 0.00191 0.00541 65 0.05493 0.00214 0.00480 93 0.00723 0.62500 142.721 0.53297 0.63496
metA; homoserine O-succinyltransferase/O-acetyltransferase [EC:2.3.1.46 2.3.1.31] 0.05679 0.00359 0.05945 0.00191 0.00541 65 0.05493 0.00214 0.00480 93 0.00723 0.62500 142.721 0.53297 0.63496
thrA; bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3] 0.05679 0.00359 0.05945 0.00191 0.00541 65 0.05493 0.00214 0.00480 93 0.00723 0.62500 142.721 0.53297 0.63496
DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4] 0.05657 0.00360 0.06140 0.00199 0.00553 65 0.05319 0.00209 0.00474 93 0.00728 1.12742 140.106 0.26149 0.39582
gcvH, GCSH; glycine cleavage system H protein 0.05657 0.00360 0.06140 0.00199 0.00553 65 0.05319 0.00209 0.00474 93 0.00728 1.12742 140.106 0.26149 0.39582
gcvPA; glycine dehydrogenase subunit 1 [EC:1.4.4.2] 0.05657 0.00360 0.06140 0.00199 0.00553 65 0.05319 0.00209 0.00474 93 0.00728 1.12742 140.106 0.26149 0.39582
gcvPB; glycine dehydrogenase subunit 2 [EC:1.4.4.2] 0.05657 0.00360 0.06140 0.00199 0.00553 65 0.05319 0.00209 0.00474 93 0.00728 1.12742 140.106 0.26149 0.39582
gcvT, AMT; aminomethyltransferase [EC:2.1.2.10] 0.05657 0.00360 0.06140 0.00199 0.00553 65 0.05319 0.00209 0.00474 93 0.00728 1.12742 140.106 0.26149 0.39582
trpG; anthranilate synthase component II [EC:4.1.3.27] 0.05643 0.00365 0.06239 0.00202 0.00558 65 0.05226 0.00215 0.00481 93 0.00737 1.37492 140.389 0.17135 0.29378
ACSS, acs; acetyl-CoA synthetase [EC:6.2.1.1] 0.05624 0.00352 0.05970 0.00179 0.00524 65 0.05382 0.00208 0.00473 93 0.00706 0.83228 144.100 0.40663 0.52436
mgtC; putative Mg2+ transporter-C (MgtC) family protein 0.05618 0.00359 0.05800 0.00190 0.00541 65 0.05491 0.00214 0.00480 93 0.00723 0.42803 142.860 0.66928 0.75538
E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72] 0.05600 0.00504 0.06257 0.00431 0.00814 65 0.05141 0.00380 0.00639 93 0.01035 1.07894 132.233 0.28258 0.41851
MAN; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78] 0.05576 0.00357 0.05917 0.00189 0.00539 65 0.05338 0.00211 0.00476 93 0.00720 0.80456 142.509 0.42241 0.53931
hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3] 0.05558 0.00359 0.05661 0.00194 0.00546 65 0.05486 0.00213 0.00479 93 0.00726 0.24106 141.957 0.80986 0.86483
djlA; DnaJ like chaperone protein 0.05523 0.00356 0.06070 0.00197 0.00550 65 0.05140 0.00201 0.00465 93 0.00720 1.29098 138.722 0.19886 0.32713
pabB; para-aminobenzoate synthetase component I [EC:2.6.1.85] 0.05514 0.00367 0.06085 0.00206 0.00563 65 0.05116 0.00215 0.00481 93 0.00740 1.30864 139.697 0.19280 0.31941
pabC; 4-amino-4-deoxychorismate lyase [EC:4.1.3.38] 0.05514 0.00367 0.06085 0.00206 0.00563 65 0.05116 0.00215 0.00481 93 0.00740 1.30864 139.697 0.19280 0.31941
cysK; cysteine synthase A [EC:2.5.1.47] 0.05500 0.00354 0.05776 0.00183 0.00531 65 0.05307 0.00210 0.00475 93 0.00712 0.65928 143.548 0.51077 0.61420
sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5] 0.05466 0.00353 0.05965 0.00192 0.00544 65 0.05117 0.00200 0.00464 93 0.00715 1.18696 139.569 0.23726 0.37178
sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5] 0.05466 0.00353 0.05965 0.00192 0.00544 65 0.05117 0.00200 0.00464 93 0.00715 1.18696 139.569 0.23726 0.37178
fes; enterochelin esterase and related enzymes 0.05464 0.00387 0.05728 0.00200 0.00555 65 0.05279 0.00264 0.00533 93 0.00769 0.58316 148.543 0.56067 0.66250
buk; butyrate kinase [EC:2.7.2.7] 0.05406 0.00361 0.06086 0.00196 0.00549 65 0.04930 0.00210 0.00475 93 0.00726 1.59256 140.865 0.11350 0.23153
ptb; phosphate butyryltransferase [EC:2.3.1.19] 0.05406 0.00361 0.06086 0.00196 0.00549 65 0.04930 0.00210 0.00475 93 0.00726 1.59256 140.865 0.11350 0.23153
TC.NSS; neurotransmitter:Na+ symporter, NSS family 0.05399 0.00353 0.05677 0.00188 0.00537 65 0.05205 0.00205 0.00470 93 0.00714 0.66194 141.621 0.50908 0.61377
slo; thiol-activated cytolysin 0.05287 0.00433 0.05651 0.00285 0.00662 65 0.05032 0.00306 0.00574 93 0.00876 0.70668 140.908 0.48093 0.58785
INO1, ISYNA1; myo-inositol-1-phosphate synthase [EC:5.5.1.4] 0.05261 0.00363 0.05886 0.00203 0.00558 65 0.04825 0.00210 0.00475 93 0.00733 1.44661 139.341 0.15025 0.27574
nadA; quinolinate synthase [EC:2.5.1.72] 0.05257 0.00350 0.05707 0.00190 0.00541 65 0.04942 0.00196 0.00459 93 0.00710 1.07780 139.291 0.28299 0.41851
nadB; L-aspartate oxidase [EC:1.4.3.16] 0.05257 0.00350 0.05707 0.00190 0.00541 65 0.04942 0.00196 0.00459 93 0.00710 1.07780 139.291 0.28299 0.41851
nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19] 0.05257 0.00350 0.05707 0.00190 0.00541 65 0.04942 0.00196 0.00459 93 0.00710 1.07780 139.291 0.28299 0.41851
dfx; superoxide reductase [EC:1.15.1.2] 0.05231 0.00350 0.05877 0.00187 0.00537 65 0.04780 0.00194 0.00457 93 0.00705 1.55480 139.461 0.12226 0.24171
sacC, levB; levanase [EC:3.2.1.65] 0.05188 0.00350 0.05577 0.00178 0.00524 65 0.04916 0.00205 0.00470 93 0.00704 0.93976 143.662 0.34892 0.46019
cidA; holin-like protein 0.05115 0.00361 0.05733 0.00196 0.00549 65 0.04682 0.00211 0.00476 93 0.00727 1.44533 141.025 0.15058 0.27591
FTCD; glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase [EC:2.1.2.5 4.3.1.4] 0.05085 0.00351 0.05454 0.00193 0.00546 65 0.04827 0.00196 0.00459 93 0.00713 0.87947 138.406 0.38067 0.49364
hutH, HAL; histidine ammonia-lyase [EC:4.3.1.3] 0.05085 0.00351 0.05454 0.00193 0.00546 65 0.04827 0.00196 0.00459 93 0.00713 0.87947 138.406 0.38067 0.49364
hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7] 0.05085 0.00351 0.05454 0.00193 0.00546 65 0.04827 0.00196 0.00459 93 0.00713 0.87947 138.406 0.38067 0.49364
hutU, UROC1; urocanate hydratase [EC:4.2.1.49] 0.05085 0.00351 0.05454 0.00193 0.00546 65 0.04827 0.00196 0.00459 93 0.00713 0.87947 138.406 0.38067 0.49364
hppA; K(+)-stimulated pyrophosphate-energized sodium pump [EC:3.6.1.1] 0.05054 0.00342 0.05365 0.00170 0.00511 65 0.04836 0.00197 0.00460 93 0.00687 0.76915 143.981 0.44306 0.55890
K15977; putative oxidoreductase 0.05050 0.00360 0.05682 0.00198 0.00552 65 0.04608 0.00207 0.00472 93 0.00726 1.47992 139.835 0.14114 0.26235
K07387; putative metalloprotease [EC:3.4.24.-] 0.05050 0.00345 0.05218 0.00173 0.00516 65 0.04932 0.00200 0.00464 93 0.00694 0.41246 143.867 0.68062 0.76594
ybaZ; methylated-DNA-protein-cysteine methyltransferase related protein 0.05041 0.00349 0.05378 0.00177 0.00522 65 0.04805 0.00205 0.00469 93 0.00701 0.81580 143.927 0.41596 0.53284
mntH; manganese transport protein 0.05023 0.00350 0.05426 0.00176 0.00521 65 0.04741 0.00205 0.00470 93 0.00701 0.97632 144.081 0.33054 0.44098
hya; hyaluronoglucosaminidase [EC:3.2.1.35] 0.04989 0.00348 0.05315 0.00172 0.00514 65 0.04762 0.00205 0.00470 93 0.00697 0.79367 145.094 0.42868 0.54432
metF, MTHFR; methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] 0.04970 0.00346 0.05109 0.00175 0.00519 65 0.04872 0.00200 0.00464 93 0.00696 0.34073 143.377 0.73381 0.79489
ompX; outer membrane protein X 0.04961 0.00360 0.05545 0.00209 0.00567 65 0.04553 0.00201 0.00465 93 0.00733 1.35269 136.141 0.17840 0.30246
E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] 0.04937 0.00342 0.05527 0.00180 0.00526 65 0.04525 0.00186 0.00447 93 0.00690 1.45093 139.408 0.14905 0.27440
K01163; uncharacterized protein 0.04905 0.00345 0.05442 0.00183 0.00530 65 0.04530 0.00190 0.00452 93 0.00697 1.30985 139.621 0.19240 0.31941
malZ; alpha-glucosidase [EC:3.2.1.20] 0.04717 0.00349 0.05176 0.00179 0.00525 65 0.04396 0.00202 0.00466 93 0.00702 1.11112 142.932 0.26838 0.40456
ldhA; D-lactate dehydrogenase [EC:1.1.1.28] 0.04713 0.00338 0.05265 0.00174 0.00518 65 0.04327 0.00184 0.00445 93 0.00682 1.37363 140.164 0.17175 0.29378
hlyIII; hemolysin III 0.04580 0.00330 0.04853 0.00156 0.00491 65 0.04389 0.00183 0.00444 93 0.00662 0.70011 144.342 0.48499 0.59055
mviM; virulence factor 0.04568 0.00336 0.04851 0.00169 0.00510 65 0.04371 0.00185 0.00446 93 0.00678 0.70906 141.762 0.47945 0.58690
umuC; DNA polymerase V 0.04530 0.00339 0.04823 0.00178 0.00524 65 0.04325 0.00185 0.00446 93 0.00688 0.72362 139.502 0.47051 0.58301
icmF; isobutyryl-CoA mutase [EC:5.4.99.13] 0.04513 0.00338 0.04691 0.00168 0.00509 65 0.04388 0.00191 0.00453 93 0.00681 0.44362 143.078 0.65799 0.75366
abgT; aminobenzoyl-glutamate transport protein 0.04510 0.00347 0.04869 0.00183 0.00530 65 0.04260 0.00196 0.00460 93 0.00702 0.86866 140.920 0.38651 0.49897
fabB; 3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41] 0.04465 0.00509 0.03858 0.00309 0.00690 65 0.04890 0.00478 0.00717 93 0.00995 -1.03765 152.843 0.30107 0.43744
tolA; colicin import membrane protein 0.04442 0.00335 0.04842 0.00185 0.00534 65 0.04163 0.00172 0.00431 93 0.00686 0.98914 134.705 0.32437 0.43751
cas1; CRISP-associated protein Cas1 0.04423 0.00402 0.04452 0.00250 0.00620 65 0.04402 0.00262 0.00531 93 0.00816 0.06129 139.979 0.95122 0.95867
cas2; CRISPR-associated protein Cas2 0.04423 0.00402 0.04452 0.00250 0.00620 65 0.04402 0.00262 0.00531 93 0.00816 0.06129 139.979 0.95122 0.95867
K06926; uncharacterized protein 0.04382 0.00342 0.04552 0.00170 0.00512 65 0.04263 0.00196 0.00459 93 0.00688 0.41953 143.679 0.67545 0.76087
agp; glucose-1-phosphatase [EC:3.1.3.10] 0.04356 0.00336 0.04785 0.00174 0.00518 65 0.04056 0.00182 0.00442 93 0.00681 1.07094 139.687 0.28604 0.42250
glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3] 0.04339 0.00329 0.04789 0.00159 0.00495 65 0.04024 0.00179 0.00439 93 0.00662 1.15500 142.778 0.25002 0.38443
glpB; glycerol-3-phosphate dehydrogenase subunit B [EC:1.1.5.3] 0.04339 0.00329 0.04789 0.00159 0.00495 65 0.04024 0.00179 0.00439 93 0.00662 1.15500 142.778 0.25002 0.38443
glpC; glycerol-3-phosphate dehydrogenase subunit C [EC:1.1.5.3] 0.04339 0.00329 0.04789 0.00159 0.00495 65 0.04024 0.00179 0.00439 93 0.00662 1.15500 142.778 0.25002 0.38443
kup; KUP system potassium uptake protein 0.04274 0.00347 0.04774 0.00196 0.00549 65 0.03925 0.00186 0.00447 93 0.00708 1.19788 135.474 0.23306 0.36668
panE, apbA; 2-dehydropantoate 2-reductase [EC:1.1.1.169] 0.04170 0.00329 0.04363 0.00167 0.00507 65 0.04036 0.00176 0.00435 93 0.00668 0.48927 140.055 0.62542 0.72135
K07003; uncharacterized protein 0.04119 0.00321 0.04334 0.00157 0.00491 65 0.03968 0.00168 0.00425 93 0.00650 0.56202 140.788 0.57500 0.67667
K09975; uncharacterized protein 0.04066 0.00327 0.04356 0.00176 0.00521 65 0.03863 0.00165 0.00421 93 0.00669 0.73663 134.922 0.46263 0.57956
K08987; putative membrane protein 0.04056 0.00347 0.04815 0.00201 0.00555 65 0.03525 0.00177 0.00437 93 0.00707 1.82586 132.417 0.07012 0.23153
ABC.CD.P; putative ABC transport system permease protein 0.03931 0.00542 0.03298 0.00296 0.00675 65 0.04374 0.00580 0.00790 93 0.01039 -1.03632 155.910 0.30166 0.43751
K08884; serine/threonine protein kinase, bacterial [EC:2.7.11.1] 0.03872 0.00322 0.04380 0.00168 0.00508 65 0.03518 0.00160 0.00415 93 0.00656 1.31356 135.753 0.19121 0.31853
cynT, can; carbonic anhydrase [EC:4.2.1.1] 0.03804 0.00324 0.03960 0.00166 0.00505 65 0.03694 0.00167 0.00424 93 0.00659 0.40361 138.123 0.68713 0.77177
dam; DNA adenine methylase [EC:2.1.1.72] 0.03744 0.00346 0.03763 0.00155 0.00489 65 0.03731 0.00214 0.00480 93 0.00685 0.04551 149.973 0.96376 0.96878
E3.1.6.1, aslA; arylsulfatase [EC:3.1.6.1] 0.03726 0.00323 0.03915 0.00161 0.00498 65 0.03594 0.00169 0.00426 93 0.00655 0.48966 139.740 0.62514 0.72135
fsr; MFS transporter, FSR family, fosmidomycin resistance protein 0.03587 0.00317 0.03982 0.00162 0.00500 65 0.03312 0.00157 0.00411 93 0.00647 1.03568 136.409 0.30218 0.43751
E5.2.1.8; peptidylprolyl isomerase [EC:5.2.1.8] 0.03516 0.00317 0.03900 0.00166 0.00506 65 0.03247 0.00154 0.00407 93 0.00649 1.00683 134.554 0.31582 0.43751
SERPINB; serpin B 0.03514 0.00314 0.03756 0.00160 0.00496 65 0.03345 0.00153 0.00406 93 0.00641 0.64122 136.079 0.52246 0.62565
K07088; uncharacterized protein 0.03455 0.00314 0.03756 0.00160 0.00496 65 0.03245 0.00154 0.00407 93 0.00642 0.79650 136.364 0.42712 0.54353
sanA; SanA protein 0.03455 0.00314 0.03756 0.00160 0.00496 65 0.03245 0.00154 0.00407 93 0.00642 0.79650 136.364 0.42712 0.54353
thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17] 0.03414 0.00316 0.04023 0.00169 0.00510 65 0.02988 0.00147 0.00397 93 0.00646 1.60263 131.654 0.11141 0.23153
THI4, THI1; cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60] 0.03395 0.00316 0.03978 0.00171 0.00513 65 0.02988 0.00147 0.00397 93 0.00649 1.52597 131.028 0.12943 0.24692
wbpO; UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.-] 0.03311 0.00314 0.03724 0.00171 0.00513 65 0.03022 0.00145 0.00395 93 0.00647 1.08462 130.609 0.28009 0.41774
yjdF; putative membrane protein 0.03190 0.00301 0.03271 0.00135 0.00456 65 0.03133 0.00151 0.00402 93 0.00608 0.22834 142.339 0.81971 0.87085
capA, pgsA; gamma-polyglutamate biosynthesis protein CapA 0.03180 0.00294 0.03489 0.00138 0.00461 65 0.02964 0.00135 0.00381 93 0.00599 0.87814 136.818 0.38141 0.49398
lacA; galactoside O-acetyltransferase [EC:2.3.1.18] 0.03173 0.00303 0.03744 0.00153 0.00486 65 0.02775 0.00137 0.00384 93 0.00619 1.56367 132.962 0.12027 0.23930
lrp; Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein 0.03161 0.00299 0.03495 0.00139 0.00463 65 0.02927 0.00143 0.00392 93 0.00607 0.93501 138.904 0.35141 0.46295
higA; HTH-type transcriptional regulator / antitoxin HigA 0.03160 0.00302 0.03335 0.00142 0.00467 65 0.03037 0.00146 0.00397 93 0.00613 0.48496 139.203 0.62847 0.72415
GLPF; glycerol uptake facilitator protein 0.03061 0.00288 0.03588 0.00137 0.00459 65 0.02693 0.00125 0.00366 93 0.00587 1.52492 133.711 0.12964 0.24692
glpK, GK; glycerol kinase [EC:2.7.1.30] 0.03061 0.00288 0.03588 0.00137 0.00459 65 0.02693 0.00125 0.00366 93 0.00587 1.52492 133.711 0.12964 0.24692
RETSAT; all-trans-retinol 13,14-reductase [EC:1.3.99.23] 0.03053 0.00398 0.02711 0.00205 0.00562 65 0.03293 0.00283 0.00552 93 0.00787 -0.73918 150.001 0.46095 0.57956
K07054; uncharacterized protein 0.03010 0.00296 0.03223 0.00137 0.00459 65 0.02860 0.00140 0.00388 93 0.00601 0.60408 138.857 0.54677 0.65007
pheA2; prephenate dehydratase [EC:4.2.1.51] 0.02919 0.00297 0.02663 0.00129 0.00445 65 0.03098 0.00148 0.00399 93 0.00598 -0.72712 143.767 0.46834 0.58301
K09797; uncharacterized protein 0.02815 0.00302 0.02944 0.00150 0.00480 65 0.02725 0.00141 0.00389 93 0.00618 0.35407 135.238 0.72384 0.79489
K07729; putative transcriptional regulator 0.02704 0.00283 0.03106 0.00138 0.00461 65 0.02422 0.00117 0.00355 93 0.00582 1.17590 130.545 0.24177 0.37732
csn1, cas9; CRISPR-associated endonuclease Csn1 [EC:3.1.-.-] 0.02677 0.00323 0.02789 0.00154 0.00487 65 0.02598 0.00175 0.00434 93 0.00652 0.29266 143.216 0.77020 0.82583
cobN; cobaltochelatase CobN [EC:6.6.1.2] 0.02576 0.00295 0.02817 0.00146 0.00474 65 0.02407 0.00133 0.00377 93 0.00606 0.67625 133.514 0.50005 0.60634
E3.1.21.4; type II restriction enzyme [EC:3.1.21.4] 0.02567 0.00359 0.02945 0.00208 0.00566 65 0.02303 0.00201 0.00465 93 0.00732 0.87744 136.398 0.38179 0.49398
aqpZ; aquaporin Z 0.02530 0.00279 0.02755 0.00120 0.00430 65 0.02372 0.00126 0.00368 93 0.00566 0.67769 139.883 0.49909 0.60634
gmuG; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78] 0.02528 0.00409 0.02006 0.00189 0.00539 65 0.02893 0.00316 0.00583 93 0.00795 -1.11661 154.356 0.26590 0.40197
mltF; membrane-bound lytic murein transglycosylase F [EC:4.2.2.-] 0.02527 0.00282 0.02544 0.00124 0.00437 65 0.02514 0.00129 0.00372 93 0.00574 0.05243 139.354 0.95826 0.96468
SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1] 0.02510 0.00279 0.02643 0.00132 0.00450 65 0.02416 0.00118 0.00356 93 0.00574 0.39667 132.985 0.69225 0.77590
kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45] 0.02497 0.00396 0.02303 0.00204 0.00560 65 0.02633 0.00279 0.00548 93 0.00784 -0.42171 149.719 0.67384 0.75979
K06975; uncharacterized protein 0.02456 0.00308 0.02417 0.00123 0.00435 65 0.02484 0.00170 0.00427 93 0.00609 -0.10949 149.943 0.91296 0.93531
trpC; indole-3-glycerol phosphate synthase [EC:4.1.1.48] 0.02454 0.00268 0.02568 0.00114 0.00419 65 0.02375 0.00114 0.00349 93 0.00546 0.35538 137.635 0.72285 0.79489
K09117; uncharacterized protein 0.02436 0.00284 0.02433 0.00125 0.00439 65 0.02437 0.00130 0.00373 93 0.00576 -0.00719 139.295 0.99428 0.99428
znuB; zinc transport system permease protein 0.02399 0.00275 0.02390 0.00116 0.00423 65 0.02406 0.00123 0.00364 93 0.00558 -0.02940 140.293 0.97659 0.97743
znuC; zinc transport system ATP-binding protein [EC:3.6.3.-] 0.02399 0.00275 0.02390 0.00116 0.00423 65 0.02406 0.00123 0.00364 93 0.00558 -0.02940 140.293 0.97659 0.97743
htpX; heat shock protein HtpX [EC:3.4.24.-] 0.02303 0.00278 0.02277 0.00122 0.00432 65 0.02321 0.00123 0.00364 93 0.00565 -0.07722 138.486 0.93856 0.95220
ABC.CD.TX; HlyD family secretion protein 0.02302 0.00306 0.02093 0.00109 0.00410 65 0.02448 0.00177 0.00436 93 0.00598 -0.59233 153.793 0.55450 0.65589
ABC.X2.P; putative ABC transport system permease protein 0.02250 0.00276 0.02236 0.00122 0.00433 65 0.02259 0.00121 0.00361 93 0.00564 -0.04022 137.638 0.96798 0.97218
fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] 0.02233 0.00254 0.01929 0.00077 0.00345 65 0.02445 0.00119 0.00358 93 0.00497 -1.03765 152.843 0.30107 0.43744
glf; UDP-galactopyranose mutase [EC:5.4.99.9] 0.02199 0.00267 0.02439 0.00127 0.00442 65 0.02032 0.00103 0.00333 93 0.00554 0.73396 128.492 0.46431 0.58064
queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50] 0.02176 0.00271 0.02371 0.00126 0.00439 65 0.02040 0.00110 0.00345 93 0.00558 0.59362 132.130 0.55378 0.65570
tolC; outer membrane protein 0.02171 0.00281 0.02008 0.00102 0.00396 65 0.02286 0.00142 0.00391 93 0.00556 -0.50077 150.335 0.61726 0.71337
APEX1; AP endonuclease 1 [EC:4.2.99.18] 0.02163 0.00261 0.02494 0.00115 0.00420 65 0.01932 0.00102 0.00331 93 0.00535 1.05067 132.664 0.29532 0.43125
ermC, ermA; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184] 0.02163 0.00261 0.02494 0.00115 0.00420 65 0.01932 0.00102 0.00331 93 0.00535 1.05067 132.664 0.29532 0.43125
mvpA, vapC; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-] 0.02163 0.00261 0.02494 0.00115 0.00420 65 0.01932 0.00102 0.00331 93 0.00535 1.05067 132.664 0.29532 0.43125
dcuA; anaerobic C4-dicarboxylate transporter DcuA 0.02135 0.00262 0.02358 0.00116 0.00422 65 0.01979 0.00103 0.00333 93 0.00538 0.70516 132.658 0.48195 0.58809
E3.1.3.1, phoA, phoB; alkaline phosphatase [EC:3.1.3.1] 0.02018 0.00261 0.02229 0.00125 0.00439 65 0.01871 0.00096 0.00321 93 0.00544 0.65972 125.580 0.51064 0.61420
bgaB, lacA; beta-galactosidase [EC:3.2.1.23] 0.02008 0.00252 0.02024 0.00100 0.00392 65 0.01997 0.00102 0.00331 93 0.00513 0.05169 138.838 0.95885 0.96468
K07483; transposase 0.01978 0.00253 0.02058 0.00104 0.00400 65 0.01922 0.00100 0.00327 93 0.00517 0.26321 136.017 0.79279 0.84900
mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72] 0.01970 0.00260 0.02367 0.00121 0.00432 65 0.01693 0.00096 0.00321 93 0.00538 1.25193 127.301 0.21289 0.34528
ABC.CD.A; putative ABC transport system ATP-binding protein 0.01936 0.00261 0.01649 0.00074 0.00337 65 0.02137 0.00131 0.00375 93 0.00505 -0.96726 155.136 0.33492 0.44477
pepE; dipeptidase E [EC:3.4.13.21] 0.01932 0.00254 0.01907 0.00101 0.00395 65 0.01950 0.00103 0.00333 93 0.00516 -0.08239 138.690 0.93446 0.95005
E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19] 0.01888 0.00250 0.02073 0.00113 0.00417 65 0.01759 0.00090 0.00310 93 0.00519 0.60313 127.433 0.54749 0.65025
K09805; uncharacterized protein 0.01829 0.00253 0.01790 0.00099 0.00391 65 0.01856 0.00103 0.00333 93 0.00514 -0.13035 139.369 0.89647 0.93531
E3.2.1.89; arabinogalactan endo-1,4-beta-galactosidase [EC:3.2.1.89] 0.01820 0.00245 0.01879 0.00099 0.00390 65 0.01778 0.00092 0.00315 93 0.00501 0.20214 134.941 0.84011 0.89007
purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] 0.01785 0.00245 0.01761 0.00082 0.00356 65 0.01801 0.00104 0.00335 93 0.00489 -0.08342 147.339 0.93363 0.95004
NAGLU; alpha-N-acetylglucosaminidase [EC:3.2.1.50] 0.01686 0.00360 0.01349 0.00167 0.00507 65 0.01922 0.00232 0.00499 93 0.00712 -0.80581 150.074 0.42163 0.53890
E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46] 0.01663 0.00267 0.01714 0.00120 0.00429 65 0.01627 0.00109 0.00343 93 0.00549 0.15690 133.798 0.87556 0.91672
K09924; uncharacterized protein 0.01617 0.00218 0.01872 0.00081 0.00352 65 0.01439 0.00071 0.00277 93 0.00448 0.96783 132.559 0.33489 0.44477
murQ; N-acetylmuramic acid 6-phosphate etherase [EC:4.2.1.126] 0.01608 0.00236 0.01445 0.00071 0.00331 65 0.01722 0.00100 0.00327 93 0.00466 -0.59501 150.289 0.55273 0.65513
wcaJ; putative colanic acid biosysnthesis UDP-glucose lipid carrier transferase 0.01604 0.00219 0.01667 0.00073 0.00335 65 0.01561 0.00078 0.00290 93 0.00443 0.24048 140.834 0.81031 0.86483
abnA; arabinan endo-1,5-alpha-L-arabinosidase [EC:3.2.1.99] 0.01593 0.00226 0.01478 0.00071 0.00330 65 0.01673 0.00088 0.00307 93 0.00451 -0.43062 146.493 0.66737 0.75397
pspC; phage shock protein C 0.01586 0.00219 0.01622 0.00073 0.00336 65 0.01561 0.00078 0.00290 93 0.00444 0.13815 140.744 0.89032 0.93134
vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-] 0.01584 0.00233 0.01620 0.00075 0.00339 65 0.01559 0.00094 0.00318 93 0.00465 0.13151 147.076 0.89556 0.93531
dapF; diaminopimelate epimerase [EC:5.1.1.7] 0.01560 0.00221 0.01611 0.00075 0.00340 65 0.01525 0.00079 0.00292 93 0.00448 0.19400 140.012 0.84646 0.89516
E2.6.1.83; LL-diaminopimelate aminotransferase [EC:2.6.1.83] 0.01560 0.00221 0.01611 0.00075 0.00340 65 0.01525 0.00079 0.00292 93 0.00448 0.19400 140.012 0.84646 0.89516
fecA; Fe(3+) dicitrate transport protein 0.01536 0.00236 0.01861 0.00106 0.00405 65 0.01309 0.00075 0.00284 93 0.00494 1.11684 122.110 0.26626 0.40199
ihfA, himA; integration host factor subunit alpha 0.01532 0.00219 0.01551 0.00068 0.00323 65 0.01520 0.00082 0.00298 93 0.00439 0.07090 145.844 0.94357 0.95428
cynR; LysR family transcriptional regulator, cyn operon transcriptional activator 0.01489 0.00218 0.01699 0.00078 0.00346 65 0.01342 0.00074 0.00281 93 0.00446 0.79832 135.417 0.42608 0.54339
uxaC; glucuronate isomerase [EC:5.3.1.12] 0.01483 0.00230 0.01242 0.00060 0.00305 65 0.01650 0.00099 0.00327 93 0.00447 -0.91263 154.088 0.36286 0.47480
xylS, yicI; alpha-D-xyloside xylohydrolase [EC:3.2.1.177] 0.01481 0.00221 0.01322 0.00064 0.00314 65 0.01593 0.00087 0.00307 93 0.00439 -0.61788 149.676 0.53760 0.63981
apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12] 0.01464 0.00220 0.01277 0.00061 0.00306 65 0.01596 0.00088 0.00307 93 0.00434 -0.73588 151.027 0.46295 0.57956
TC.GPH; glycoside/pentoside/hexuronide:cation symporter, GPH family 0.01464 0.00220 0.01277 0.00061 0.00306 65 0.01596 0.00088 0.00307 93 0.00434 -0.73588 151.027 0.46295 0.57956
thrC; threonine synthase [EC:4.2.3.1] 0.01464 0.00220 0.01277 0.00061 0.00306 65 0.01596 0.00088 0.00307 93 0.00434 -0.73588 151.027 0.46295 0.57956
K06872; uncharacterized protein 0.01430 0.00216 0.01699 0.00078 0.00346 65 0.01242 0.00071 0.00277 93 0.00443 1.02940 133.951 0.30515 0.43751
cobC, phpB; alpha-ribazole phosphatase [EC:3.1.3.73] 0.01386 0.00207 0.01199 0.00050 0.00278 65 0.01516 0.00081 0.00294 93 0.00405 -0.78373 153.588 0.43440 0.54909
cobP, cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62] 0.01386 0.00207 0.01199 0.00050 0.00278 65 0.01516 0.00081 0.00294 93 0.00405 -0.78373 153.588 0.43440 0.54909
E2.4.2.21, cobU, cobT; nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21] 0.01386 0.00207 0.01199 0.00050 0.00278 65 0.01516 0.00081 0.00294 93 0.00405 -0.78373 153.588 0.43440 0.54909
E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26] 0.01386 0.00207 0.01199 0.00050 0.00278 65 0.01516 0.00081 0.00294 93 0.00405 -0.78373 153.588 0.43440 0.54909
yafQ; mRNA interferase YafQ [EC:3.1.-.-] 0.01383 0.00216 0.01373 0.00071 0.00331 65 0.01390 0.00076 0.00287 93 0.00438 -0.03819 140.855 0.96959 0.97295
lctP; lactate permease 0.01364 0.00214 0.01394 0.00064 0.00313 65 0.01343 0.00079 0.00292 93 0.00428 0.12086 146.651 0.90397 0.93531
K07126; uncharacterized protein 0.01351 0.00210 0.01509 0.00069 0.00326 65 0.01240 0.00071 0.00276 93 0.00427 0.62845 139.125 0.53074 0.63425
eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] 0.01342 0.00217 0.01229 0.00061 0.00306 65 0.01421 0.00084 0.00300 93 0.00429 -0.44784 149.868 0.65492 0.75088
arnE; undecaprenyl phosphate-alpha-L-ara4N flippase subunit ArnE 0.01341 0.00207 0.01100 0.00049 0.00276 65 0.01509 0.00081 0.00294 93 0.00403 -1.01364 153.927 0.31234 0.43751
K07727; putative transcriptional regulator 0.01323 0.00206 0.01596 0.00077 0.00344 65 0.01133 0.00060 0.00254 93 0.00427 1.08347 126.692 0.28066 0.41774
fadL; long-chain fatty acid transport protein 0.01321 0.00206 0.01299 0.00062 0.00308 65 0.01336 0.00072 0.00278 93 0.00415 -0.08848 144.144 0.92962 0.94679
TC.ZIP, zupT, ZRT3, ZIP2; zinc transporter, ZIP family 0.01311 0.00203 0.01436 0.00067 0.00320 65 0.01223 0.00064 0.00263 93 0.00415 0.51422 136.271 0.60793 0.70398
cbe, mbe; cellobiose epimerase [EC:5.1.3.11] 0.01291 0.00206 0.01023 0.00048 0.00272 65 0.01478 0.00080 0.00293 93 0.00399 -1.13685 154.246 0.25737 0.39294
mgp; 4-O-beta-D-mannosyl-D-glucose phosphorylase [EC:2.4.1.281] 0.01291 0.00206 0.01023 0.00048 0.00272 65 0.01478 0.00080 0.00293 93 0.00399 -1.13685 154.246 0.25737 0.39294
E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6] 0.01284 0.00206 0.01229 0.00061 0.00306 65 0.01323 0.00072 0.00278 93 0.00414 -0.22910 144.632 0.81912 0.87085
E2.2.1.6S, ilvH, ilvN; acetolactate synthase I/III small subunit [EC:2.2.1.6] 0.01284 0.00206 0.01229 0.00061 0.00306 65 0.01323 0.00072 0.00278 93 0.00414 -0.22910 144.632 0.81912 0.87085
ilvC; ketol-acid reductoisomerase [EC:1.1.1.86] 0.01284 0.00206 0.01229 0.00061 0.00306 65 0.01323 0.00072 0.00278 93 0.00414 -0.22910 144.632 0.81912 0.87085
ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9] 0.01284 0.00206 0.01229 0.00061 0.00306 65 0.01323 0.00072 0.00278 93 0.00414 -0.22910 144.632 0.81912 0.87085
idnO; gluconate 5-dehydrogenase [EC:1.1.1.69] 0.01284 0.00206 0.01231 0.00061 0.00307 65 0.01321 0.00072 0.00278 93 0.00414 -0.21610 144.380 0.82921 0.87933
xylB, XYLB; xylulokinase [EC:2.7.1.17] 0.01283 0.00206 0.01229 0.00061 0.00306 65 0.01321 0.00072 0.00278 93 0.00414 -0.22242 144.558 0.82430 0.87492
ald; alanine dehydrogenase [EC:1.4.1.1] 0.01276 0.00206 0.01200 0.00061 0.00306 65 0.01328 0.00072 0.00278 93 0.00414 -0.30938 144.568 0.75748 0.81294
abfA; alpha-N-arabinofuranosidase [EC:3.2.1.55] 0.01248 0.00207 0.01233 0.00063 0.00312 65 0.01259 0.00071 0.00276 93 0.00417 -0.06154 142.757 0.95102 0.95867
K09955; uncharacterized protein 0.01248 0.00207 0.01233 0.00063 0.00312 65 0.01259 0.00071 0.00276 93 0.00417 -0.06154 142.757 0.95102 0.95867
exuT; MFS transporter, ACS family, hexuronate transporter 0.01230 0.00205 0.01188 0.00060 0.00305 65 0.01259 0.00071 0.00276 93 0.00411 -0.17255 144.618 0.86324 0.90959
TC.SSS; solute:Na+ symporter, SSS family 0.01230 0.00205 0.01188 0.00060 0.00305 65 0.01259 0.00071 0.00276 93 0.00411 -0.17255 144.618 0.86324 0.90959
uxuA; mannonate dehydratase [EC:4.2.1.8] 0.01230 0.00205 0.01188 0.00060 0.00305 65 0.01259 0.00071 0.00276 93 0.00411 -0.17255 144.618 0.86324 0.90959
glpT; MFS transporter, OPA family, glycerol-3-phosphate transporter 0.01209 0.00197 0.01191 0.00059 0.00302 65 0.01222 0.00064 0.00262 93 0.00400 -0.07975 140.865 0.93655 0.95133
K02477; two-component system, LytTR family, response regulator 0.01190 0.00195 0.01385 0.00063 0.00313 65 0.01054 0.00058 0.00250 93 0.00400 0.82813 133.800 0.40907 0.52634
algI; alginate O-acetyltransferase complex protein AlgI 0.01172 0.00195 0.01340 0.00063 0.00312 65 0.01054 0.00058 0.00250 93 0.00400 0.71514 133.872 0.47577 0.58301
cobA, btuR; cob(I)alamin adenosyltransferase [EC:2.5.1.17] 0.01172 0.00195 0.01340 0.00063 0.00312 65 0.01054 0.00058 0.00250 93 0.00400 0.71514 133.872 0.47577 0.58301
dcuB; anaerobic C4-dicarboxylate transporter DcuB 0.01172 0.00195 0.01340 0.00063 0.00312 65 0.01054 0.00058 0.00250 93 0.00400 0.71514 133.872 0.47577 0.58301
E4.2.1.2AA, fumA; fumarate hydratase subunit alpha [EC:4.2.1.2] 0.01172 0.00195 0.01340 0.00063 0.00312 65 0.01054 0.00058 0.00250 93 0.00400 0.71514 133.872 0.47577 0.58301
E4.2.1.2AB, fumB; fumarate hydratase subunit beta [EC:4.2.1.2] 0.01172 0.00195 0.01340 0.00063 0.00312 65 0.01054 0.00058 0.00250 93 0.00400 0.71514 133.872 0.47577 0.58301
glmE, mutE, mamB; methylaspartate mutase epsilon subunit [EC:5.4.99.1] 0.01172 0.00195 0.01340 0.00063 0.00312 65 0.01054 0.00058 0.00250 93 0.00400 0.71514 133.872 0.47577 0.58301
glmS, mutS, mamA; methylaspartate mutase sigma subunit [EC:5.4.99.1] 0.01172 0.00195 0.01340 0.00063 0.00312 65 0.01054 0.00058 0.00250 93 0.00400 0.71514 133.872 0.47577 0.58301
inlA; internalin A 0.01172 0.00195 0.01340 0.00063 0.00312 65 0.01054 0.00058 0.00250 93 0.00400 0.71514 133.872 0.47577 0.58301
mal; methylaspartate ammonia-lyase [EC:4.3.1.2] 0.01172 0.00195 0.01340 0.00063 0.00312 65 0.01054 0.00058 0.00250 93 0.00400 0.71514 133.872 0.47577 0.58301
PCYT1; choline-phosphate cytidylyltransferase [EC:2.7.7.15] 0.01172 0.00195 0.01340 0.00063 0.00312 65 0.01054 0.00058 0.00250 93 0.00400 0.71514 133.872 0.47577 0.58301
tnaA; tryptophanase [EC:4.1.99.1] 0.01172 0.00195 0.01340 0.00063 0.00312 65 0.01054 0.00058 0.00250 93 0.00400 0.71514 133.872 0.47577 0.58301
znuA; zinc transport system substrate-binding protein 0.01170 0.00207 0.01250 0.00070 0.00328 65 0.01114 0.00067 0.00268 93 0.00423 0.32142 135.836 0.74838 0.80692
terC; tellurite resistance protein TerC 0.01167 0.00191 0.01091 0.00049 0.00275 65 0.01220 0.00064 0.00262 93 0.00380 -0.34023 147.959 0.73417 0.79489
thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148] 0.01167 0.00191 0.01091 0.00049 0.00275 65 0.01220 0.00064 0.00262 93 0.00380 -0.34023 147.959 0.73417 0.79489
ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63] 0.01149 0.00190 0.01046 0.00049 0.00274 65 0.01220 0.00064 0.00262 93 0.00379 -0.46052 148.209 0.64582 0.74192
araA; L-arabinose isomerase [EC:5.3.1.4] 0.01103 0.00189 0.01033 0.00048 0.00272 65 0.01151 0.00063 0.00260 93 0.00376 -0.31245 148.256 0.75514 0.81193
araD, ulaF, sgaE, sgbE; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4] 0.01103 0.00189 0.01033 0.00048 0.00272 65 0.01151 0.00063 0.00260 93 0.00376 -0.31245 148.256 0.75514 0.81193
E3.1.1.11; pectinesterase [EC:3.1.1.11] 0.01095 0.00190 0.01025 0.00050 0.00278 65 0.01144 0.00063 0.00260 93 0.00381 -0.31024 146.579 0.75682 0.81294
K07090; uncharacterized protein 0.01091 0.00194 0.01204 0.00069 0.00326 65 0.01011 0.00053 0.00238 93 0.00404 0.47733 125.481 0.63396 0.72974
kduI; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase [EC:5.3.1.17] 0.01076 0.00188 0.00980 0.00047 0.00270 65 0.01144 0.00063 0.00260 93 0.00374 -0.43667 148.744 0.66298 0.75397
PTS-Gat-EIIC, gatC, sgcC; PTS system, galactitol-specific IIC component 0.01076 0.00188 0.00980 0.00047 0.00270 65 0.01144 0.00063 0.00260 93 0.00374 -0.43667 148.744 0.66298 0.75397
uxaA; altronate hydrolase [EC:4.2.1.7] 0.01076 0.00188 0.00980 0.00047 0.00270 65 0.01144 0.00063 0.00260 93 0.00374 -0.43667 148.744 0.66298 0.75397
uxaB; tagaturonate reductase [EC:1.1.1.58] 0.01076 0.00188 0.00980 0.00047 0.00270 65 0.01144 0.00063 0.00260 93 0.00374 -0.43667 148.744 0.66298 0.75397
cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-] 0.01058 0.00188 0.00935 0.00047 0.00268 65 0.01144 0.00063 0.00260 93 0.00373 -0.55924 149.063 0.57684 0.67677
K08961; chondroitin-sulfate-ABC endolyase/exolyase [EC:4.2.2.20 4.2.2.21] 0.01058 0.00188 0.00935 0.00047 0.00268 65 0.01144 0.00063 0.00260 93 0.00373 -0.55924 149.063 0.57684 0.67677
uxuB; fructuronate reductase [EC:1.1.1.57] 0.01058 0.00188 0.00935 0.00047 0.00268 65 0.01144 0.00063 0.00260 93 0.00373 -0.55924 149.063 0.57684 0.67677
INV, sacA; beta-fructofuranosidase [EC:3.2.1.26] 0.00992 0.00184 0.00842 0.00041 0.00252 65 0.01097 0.00062 0.00258 93 0.00361 -0.70604 152.173 0.48124 0.58785
pgsA, PGS1; CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5] 0.00979 0.00194 0.01075 0.00064 0.00313 65 0.00911 0.00057 0.00248 93 0.00399 0.40894 133.362 0.68324 0.76815
tetM, tetO; ribosomal protection tetracycline resistance protein 0.00966 0.00181 0.01075 0.00052 0.00282 65 0.00890 0.00052 0.00237 93 0.00369 0.50305 138.179 0.61573 0.71231
yoeB; toxin YoeB [EC:3.1.-.-] 0.00962 0.00198 0.01174 0.00074 0.00337 65 0.00813 0.00053 0.00240 93 0.00413 0.87300 123.201 0.38436 0.49675
E3.2.1.17; lysozyme [EC:3.2.1.17] 0.00941 0.00190 0.01247 0.00076 0.00341 65 0.00727 0.00044 0.00217 93 0.00405 1.28593 113.342 0.20109 0.32937
lolA; outer membrane lipoprotein carrier protein 0.00938 0.00176 0.00841 0.00040 0.00247 65 0.01005 0.00056 0.00245 93 0.00348 -0.47251 150.457 0.63725 0.73280
aat; leucyl/phenylalanyl-tRNA—protein transferase [EC:2.3.2.6] 0.00920 0.00191 0.01075 0.00064 0.00313 65 0.00811 0.00053 0.00240 93 0.00394 0.66885 130.040 0.50478 0.60952
clpA; ATP-dependent Clp protease ATP-binding subunit ClpA 0.00920 0.00191 0.01075 0.00064 0.00313 65 0.00811 0.00053 0.00240 93 0.00394 0.66885 130.040 0.50478 0.60952
clpS; ATP-dependent Clp protease adaptor protein ClpS 0.00920 0.00191 0.01075 0.00064 0.00313 65 0.00811 0.00053 0.00240 93 0.00394 0.66885 130.040 0.50478 0.60952
PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] 0.00913 0.00190 0.01036 0.00063 0.00311 65 0.00828 0.00053 0.00240 93 0.00393 0.53015 130.380 0.59691 0.69399
troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator 0.00913 0.00190 0.01036 0.00063 0.00311 65 0.00828 0.00053 0.00240 93 0.00393 0.53015 130.380 0.59691 0.69399
cusB, silB; membrane fusion protein, Cu(I)/Ag(I) efflux system 0.00903 0.00181 0.01204 0.00070 0.00329 65 0.00693 0.00039 0.00204 93 0.00387 1.32076 111.440 0.18929 0.31584
K07504; predicted type IV restriction endonuclease 0.00901 0.00190 0.01029 0.00063 0.00312 65 0.00811 0.00053 0.00240 93 0.00393 0.55484 130.321 0.57995 0.67837
norB; nitric oxide reductase subunit B [EC:1.7.2.5] 0.00901 0.00190 0.01029 0.00063 0.00312 65 0.00811 0.00053 0.00240 93 0.00393 0.55484 130.321 0.57995 0.67837
TC.FEV.OM3, tbpA, hemR, lbpA, hpuB, bhuR, hugA, hmbR; hemoglobin/transferrin/lactoferrin receptor protein 0.00901 0.00190 0.01029 0.00063 0.00312 65 0.00811 0.00053 0.00240 93 0.00393 0.55484 130.321 0.57995 0.67837
xapB; MFS transporter, NHS family, xanthosine permease 0.00900 0.00185 0.01150 0.00070 0.00327 65 0.00725 0.00043 0.00215 93 0.00392 1.08425 116.177 0.28050 0.41774
ccrM; modification methylase [EC:2.1.1.72] 0.00865 0.00164 0.00895 0.00037 0.00238 65 0.00843 0.00047 0.00224 93 0.00327 0.15863 147.124 0.87418 0.91611
K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72] 0.00865 0.00164 0.00895 0.00037 0.00238 65 0.00843 0.00047 0.00224 93 0.00327 0.15863 147.124 0.87418 0.91611
czcA; cobalt-zinc-cadmium resistance protein CzcA 0.00861 0.00205 0.01316 0.00112 0.00415 65 0.00543 0.00033 0.00190 93 0.00456 1.69534 90.794 0.09344 0.23153
gpr; L-glyceraldehyde 3-phosphate reductase [EC:1.1.1.-] 0.00848 0.00189 0.01136 0.00075 0.00341 65 0.00647 0.00043 0.00215 93 0.00403 1.21303 112.810 0.22765 0.35965
mrr; restriction system protein 0.00848 0.00177 0.00810 0.00034 0.00228 65 0.00874 0.00061 0.00257 93 0.00344 -0.18597 155.381 0.85271 0.90095
dexA; dextranase [EC:3.2.1.11] 0.00812 0.00163 0.00794 0.00041 0.00251 65 0.00825 0.00043 0.00215 93 0.00331 -0.09245 139.923 0.92648 0.94442
cusA, silA; Cu(I)/Ag(I) efflux system membrane protein CusA/SilA 0.00812 0.00172 0.01093 0.00064 0.00313 65 0.00616 0.00034 0.00192 93 0.00367 1.29734 110.472 0.19722 0.32579
pgpA; phosphatidylglycerophosphatase A [EC:3.1.3.27] 0.00799 0.00175 0.01027 0.00063 0.00313 65 0.00639 0.00038 0.00202 93 0.00372 1.04137 114.832 0.29989 0.43682
penP; beta-lactamase class A [EC:3.5.2.6] 0.00787 0.00166 0.00907 0.00045 0.00263 65 0.00704 0.00043 0.00215 93 0.00339 0.59833 135.924 0.55062 0.65329
rhaA; L-rhamnose isomerase [EC:5.3.1.14] 0.00770 0.00177 0.00696 0.00043 0.00256 65 0.00822 0.00054 0.00242 93 0.00352 -0.35937 147.559 0.71983 0.79489
rhaB; rhamnulokinase [EC:2.7.1.5] 0.00770 0.00177 0.00696 0.00043 0.00256 65 0.00822 0.00054 0.00242 93 0.00352 -0.35937 147.559 0.71983 0.79489
rhaD; rhamnulose-1-phosphate aldolase [EC:4.1.2.19] 0.00770 0.00177 0.00696 0.00043 0.00256 65 0.00822 0.00054 0.00242 93 0.00352 -0.35937 147.559 0.71983 0.79489
treS; maltose alpha-D-glucosyltransferase / alpha-amylase [EC:5.4.99.16 3.2.1.1] 0.00757 0.00175 0.00722 0.00045 0.00265 65 0.00781 0.00051 0.00234 93 0.00353 -0.16853 142.677 0.86640 0.91209
dpo; DNA polymerase bacteriophage-type [EC:2.7.7.7] 0.00721 0.00170 0.00981 0.00063 0.00311 65 0.00539 0.00033 0.00190 93 0.00365 1.21337 109.783 0.22759 0.35965
epsD; glycosyltransferase EpsD [EC:2.4.-.-] 0.00721 0.00170 0.00981 0.00063 0.00311 65 0.00539 0.00033 0.00190 93 0.00365 1.21337 109.783 0.22759 0.35965
K06904; uncharacterized protein 0.00721 0.00170 0.00981 0.00063 0.00311 65 0.00539 0.00033 0.00190 93 0.00365 1.21337 109.783 0.22759 0.35965
K07270; glycosyl transferase, family 25 0.00721 0.00170 0.00981 0.00063 0.00311 65 0.00539 0.00033 0.00190 93 0.00365 1.21337 109.783 0.22759 0.35965
K09137; uncharacterized protein 0.00721 0.00170 0.00981 0.00063 0.00311 65 0.00539 0.00033 0.00190 93 0.00365 1.21337 109.783 0.22759 0.35965
kch, trkA, mthK, pch; voltage-gated potassium channel 0.00721 0.00170 0.00981 0.00063 0.00311 65 0.00539 0.00033 0.00190 93 0.00365 1.21337 109.783 0.22759 0.35965
mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-] 0.00721 0.00170 0.00981 0.00063 0.00311 65 0.00539 0.00033 0.00190 93 0.00365 1.21337 109.783 0.22759 0.35965
mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC 0.00721 0.00170 0.00981 0.00063 0.00311 65 0.00539 0.00033 0.00190 93 0.00365 1.21337 109.783 0.22759 0.35965
PNC1; nicotinamidase [EC:3.5.1.19] 0.00721 0.00170 0.00981 0.00063 0.00311 65 0.00539 0.00033 0.00190 93 0.00365 1.21337 109.783 0.22759 0.35965
rgpB; rhamnosyltransferase [EC:2.4.1.-] 0.00721 0.00170 0.00981 0.00063 0.00311 65 0.00539 0.00033 0.00190 93 0.00365 1.21337 109.783 0.22759 0.35965
tagD; glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39] 0.00721 0.00170 0.00981 0.00063 0.00311 65 0.00539 0.00033 0.00190 93 0.00365 1.21337 109.783 0.22759 0.35965
E5.1.3.6; UDP-glucuronate 4-epimerase [EC:5.1.3.6] 0.00721 0.00154 0.00803 0.00034 0.00228 65 0.00663 0.00041 0.00209 93 0.00309 0.45053 145.185 0.65300 0.74943
pcaC; 4-carboxymuconolactone decarboxylase [EC:4.1.1.44] 0.00686 0.00153 0.00807 0.00034 0.00229 65 0.00602 0.00039 0.00204 93 0.00307 0.67038 143.289 0.50369 0.60952
E2.1.1.77, pcm; protein-L-isoaspartate(D-aspartate) O-methyltransferase [EC:2.1.1.77] 0.00668 0.00152 0.00762 0.00033 0.00227 65 0.00602 0.00039 0.00204 93 0.00305 0.52542 144.020 0.60010 0.69561
moaA, CNX2; GTP 3’,8-cyclase [EC:4.1.99.22] 0.00668 0.00152 0.00762 0.00033 0.00227 65 0.00602 0.00039 0.00204 93 0.00305 0.52542 144.020 0.60010 0.69561
UXS1, uxs; UDP-glucuronate decarboxylase [EC:4.1.1.35] 0.00668 0.00152 0.00762 0.00033 0.00227 65 0.00602 0.00039 0.00204 93 0.00305 0.52542 144.020 0.60010 0.69561
xlyAB; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] 0.00660 0.00161 0.00516 0.00029 0.00210 65 0.00761 0.00050 0.00232 93 0.00313 -0.78302 155.009 0.43481 0.54909
aguA; alpha-glucuronidase [EC:3.2.1.139] 0.00643 0.00155 0.00541 0.00029 0.00210 65 0.00714 0.00045 0.00220 93 0.00304 -0.56833 153.222 0.57064 0.67223
cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 3.6.4.-] 0.00624 0.00155 0.00496 0.00028 0.00207 65 0.00714 0.00045 0.00220 93 0.00302 -0.72255 153.826 0.47105 0.58301
cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1] 0.00624 0.00155 0.00496 0.00028 0.00207 65 0.00714 0.00045 0.00220 93 0.00302 -0.72255 153.826 0.47105 0.58301
purU; formyltetrahydrofolate deformylase [EC:3.5.1.10] 0.00624 0.00155 0.00496 0.00028 0.00207 65 0.00714 0.00045 0.00220 93 0.00302 -0.72255 153.826 0.47105 0.58301
rhaT; L-rhamnose-H+ transport protein 0.00624 0.00155 0.00496 0.00028 0.00207 65 0.00714 0.00045 0.00220 93 0.00302 -0.72255 153.826 0.47105 0.58301
lplA, lplJ; lipoate—protein ligase [EC:6.3.1.20] 0.00610 0.00158 0.00418 0.00026 0.00202 65 0.00745 0.00049 0.00229 93 0.00305 -1.06859 155.534 0.28691 0.42291
K06921; uncharacterized protein 0.00569 0.00149 0.00493 0.00029 0.00212 65 0.00622 0.00039 0.00205 93 0.00295 -0.43956 148.979 0.66090 0.75397
dinD; DNA-damage-inducible protein D 0.00527 0.00125 0.00780 0.00041 0.00251 65 0.00350 0.00013 0.00118 93 0.00277 1.55358 92.553 0.12370 0.24171
MuB; ATP-dependent target DNA activator [EC:3.6.1.3] 0.00487 0.00149 0.00493 0.00035 0.00232 65 0.00483 0.00036 0.00196 93 0.00304 0.03180 138.821 0.97467 0.97721
csm1, cas10; CRISPR-associated protein Csm1 0.00480 0.00135 0.00468 0.00028 0.00207 65 0.00489 0.00030 0.00178 93 0.00273 -0.07453 140.363 0.94069 0.95220
csm2; CRISPR-associated protein Csm2 0.00480 0.00135 0.00468 0.00028 0.00207 65 0.00489 0.00030 0.00178 93 0.00273 -0.07453 140.363 0.94069 0.95220
csm3; CRISPR-associated protein Csm3 0.00480 0.00135 0.00468 0.00028 0.00207 65 0.00489 0.00030 0.00178 93 0.00273 -0.07453 140.363 0.94069 0.95220
GLO1, gloA; lactoylglutathione lyase [EC:4.4.1.5] 0.00371 0.00125 0.00223 0.00011 0.00130 65 0.00475 0.00034 0.00193 93 0.00232 -1.08416 150.017 0.28003 0.41774
ltaE; threonine aldolase [EC:4.1.2.48] 0.00317 0.00103 0.00407 0.00021 0.00181 65 0.00254 0.00014 0.00122 93 0.00219 0.70253 117.964 0.48373 0.58964
ABC.X2.A; putative ABC transport system ATP-binding protein 0.00307 0.00128 0.00202 0.00016 0.00159 65 0.00380 0.00033 0.00188 93 0.00246 -0.72195 155.976 0.47141 0.58301
K07454; putative restriction endonuclease 0.00307 0.00118 0.00445 0.00034 0.00230 65 0.00211 0.00013 0.00120 93 0.00260 0.90155 98.601 0.36949 0.48184
rgpA_B; gingipain R [EC:3.4.22.37] 0.00307 0.00118 0.00445 0.00034 0.00230 65 0.00211 0.00013 0.00120 93 0.00260 0.90155 98.601 0.36949 0.48184
rhaM; L-rhamnose mutarotase [EC:5.1.3.32] 0.00306 0.00121 0.00323 0.00025 0.00196 65 0.00294 0.00022 0.00154 93 0.00249 0.11617 132.356 0.90769 0.93531
agaR; DeoR family transcriptional regulator, aga operon transcriptional repressor 0.00271 0.00100 0.00159 0.00004 0.00079 65 0.00349 0.00024 0.00161 93 0.00179 -1.06101 131.216 0.29063 0.42619
umuD; DNA polymerase V [EC:3.4.21.-] 0.00258 0.00104 0.00093 0.00002 0.00060 65 0.00373 0.00027 0.00170 93 0.00181 -1.54439 113.844 0.12527 0.24217
zraR, hydG; two-component system, NtrC family, response regulator HydG 0.00240 0.00102 0.00313 0.00023 0.00189 65 0.00188 0.00012 0.00112 93 0.00219 0.57039 107.782 0.56960 0.67169
padR; PadR family transcriptional regulator, regulatory protein PadR 0.00238 0.00093 0.00169 0.00010 0.00124 65 0.00286 0.00016 0.00132 93 0.00181 -0.64944 153.722 0.51703 0.62107
tatA; sec-independent protein translocase protein TatA 0.00220 0.00096 0.00266 0.00018 0.00167 65 0.00188 0.00012 0.00115 93 0.00203 0.38451 120.816 0.70128 0.78311
tatC; sec-independent protein translocase protein TatC 0.00220 0.00096 0.00266 0.00018 0.00167 65 0.00188 0.00012 0.00115 93 0.00203 0.38451 120.816 0.70128 0.78311
pnbA; para-nitrobenzyl esterase [EC:3.1.1.-] 0.00218 0.00096 0.00266 0.00018 0.00167 65 0.00185 0.00012 0.00115 93 0.00203 0.39833 120.827 0.69109 0.77547
ACO, acnA; aconitate hydratase [EC:4.2.1.3] 0.00208 0.00108 0.00344 0.00030 0.00214 65 0.00113 0.00011 0.00108 93 0.00239 0.96741 96.449 0.33576 0.44486
IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42] 0.00208 0.00108 0.00344 0.00030 0.00214 65 0.00113 0.00011 0.00108 93 0.00239 0.96741 96.449 0.33576 0.44486
argB; acetylglutamate kinase [EC:2.7.2.8] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
argE; acetylornithine deacetylase [EC:3.5.1.16] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
argF; N-succinyl-L-ornithine transcarbamylase [EC:2.1.3.11] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
argG, ASS1; argininosuccinate synthase [EC:6.3.4.5] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
argH, ASL; argininosuccinate lyase [EC:4.3.2.1] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
cimA; (R)-citramalate synthase [EC:2.3.1.182] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
E2.6.1.11, argD; acetylornithine aminotransferase [EC:2.6.1.11] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
hisB; imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase [EC:4.2.1.19 3.1.3.15] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
hisD; histidinol dehydrogenase [EC:1.1.1.23] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
hisF; cyclase [EC:4.1.3.-] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
hisG; ATP phosphoribosyltransferase [EC:2.4.2.17] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
hisH; glutamine amidotransferase [EC:2.4.2.-] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
hisIE; phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase [EC:3.6.1.31 3.5.4.19] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
leuB, IMDH; 3-isopropylmalate dehydrogenase [EC:1.1.1.85] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
leuC, IPMI-L; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
leuD, IPMI-S; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35] 0.00200 0.00095 0.00240 0.00018 0.00165 65 0.00172 0.00012 0.00115 93 0.00201 0.33903 121.434 0.73517 0.79489
trpA; tryptophan synthase alpha chain [EC:4.2.1.20] 0.00199 0.00095 0.00240 0.00018 0.00165 65 0.00170 0.00012 0.00115 93 0.00201 0.35299 121.442 0.72471 0.79489
trpD; anthranilate phosphoribosyltransferase [EC:2.4.2.18] 0.00199 0.00095 0.00240 0.00018 0.00165 65 0.00170 0.00012 0.00115 93 0.00201 0.35299 121.442 0.72471 0.79489
trpE; anthranilate synthase component I [EC:4.1.3.27] 0.00199 0.00095 0.00240 0.00018 0.00165 65 0.00170 0.00012 0.00115 93 0.00201 0.35299 121.442 0.72471 0.79489
ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:3.6.3.21] 0.00199 0.00095 0.00093 0.00002 0.00060 65 0.00272 0.00023 0.00156 93 0.00167 -1.06946 117.639 0.28705 0.42291
bdhAB; butanol dehydrogenase [EC:1.1.1.-] 0.00198 0.00085 0.00214 0.00011 0.00131 65 0.00186 0.00012 0.00112 93 0.00173 0.16109 139.604 0.87226 0.91575
sbcD, mre11; DNA repair protein SbcD/Mre11 0.00198 0.00085 0.00214 0.00011 0.00131 65 0.00186 0.00012 0.00112 93 0.00173 0.16109 139.604 0.87226 0.91575
TC.SULP; sulfate permease, SulP family 0.00198 0.00085 0.00214 0.00011 0.00131 65 0.00186 0.00012 0.00112 93 0.00173 0.16109 139.604 0.87226 0.91575
K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72] 0.00193 0.00096 0.00370 0.00029 0.00212 65 0.00069 0.00004 0.00067 93 0.00223 1.35323 76.887 0.17995 0.30420
nosL; copper chaperone NosL 0.00182 0.00074 0.00222 0.00012 0.00133 65 0.00154 0.00007 0.00086 93 0.00159 0.43147 114.686 0.66694 0.75397
K07496; putative transposase 0.00182 0.00178 0.00434 0.00122 0.00434 65 0.00006 0.00000 0.00006 93 0.00434 0.98657 64.023 0.32757 0.43751
xylA; xylose isomerase [EC:5.3.1.5] 0.00180 0.00094 0.00195 0.00016 0.00159 65 0.00170 0.00012 0.00115 93 0.00196 0.13003 124.530 0.89675 0.93531
bshA; L-malate glycosyltransferase [EC:2.4.1.-] 0.00180 0.00094 0.00048 0.00001 0.00040 65 0.00272 0.00023 0.00156 93 0.00161 -1.39048 104.095 0.16735 0.29098
csxA; exo-1,4-beta-D-glucosaminidase [EC:3.2.1.165] 0.00180 0.00094 0.00048 0.00001 0.00040 65 0.00272 0.00023 0.00156 93 0.00161 -1.39048 104.095 0.16735 0.29098
E2.5.1.56, neuB; N-acetylneuraminate synthase [EC:2.5.1.56] 0.00180 0.00094 0.00048 0.00001 0.00040 65 0.00272 0.00023 0.00156 93 0.00161 -1.39048 104.095 0.16735 0.29098
E3.5.2.10; creatinine amidohydrolase [EC:3.5.2.10] 0.00180 0.00094 0.00048 0.00001 0.00040 65 0.00272 0.00023 0.00156 93 0.00161 -1.39048 104.095 0.16735 0.29098
FLOT; flotillin 0.00180 0.00094 0.00048 0.00001 0.00040 65 0.00272 0.00023 0.00156 93 0.00161 -1.39048 104.095 0.16735 0.29098
higB-1; toxin HigB-1 0.00180 0.00094 0.00048 0.00001 0.00040 65 0.00272 0.00023 0.00156 93 0.00161 -1.39048 104.095 0.16735 0.29098
K13652; AraC family transcriptional regulator 0.00180 0.00094 0.00048 0.00001 0.00040 65 0.00272 0.00023 0.00156 93 0.00161 -1.39048 104.095 0.16735 0.29098
neuA; N-acylneuraminate cytidylyltransferase [EC:2.7.7.43] 0.00180 0.00094 0.00048 0.00001 0.00040 65 0.00272 0.00023 0.00156 93 0.00161 -1.39048 104.095 0.16735 0.29098
RTCB, rtcB; tRNA-splicing ligase RtcB (3’-phosphate/5’-hydroxy nucleic acid ligase) [EC:6.5.1.8] 0.00180 0.00094 0.00048 0.00001 0.00040 65 0.00272 0.00023 0.00156 93 0.00161 -1.39048 104.095 0.16735 0.29098
TC.CPA1; monovalent cation:H+ antiporter, CPA1 family 0.00180 0.00094 0.00048 0.00001 0.00040 65 0.00272 0.00023 0.00156 93 0.00161 -1.39048 104.095 0.16735 0.29098
amn; AMP nucleosidase [EC:3.2.2.4] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
coaX; type III pantothenate kinase [EC:2.7.1.33] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
cysC; adenylylsulfate kinase [EC:2.7.1.25] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
cysN; sulfate adenylyltransferase subunit 1 [EC:2.7.7.4] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
cysQ, MET22, BPNT1; 3’(2’), 5’-bisphosphate nucleotidase [EC:3.1.3.7] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
E3.1.11.5; exodeoxyribonuclease V [EC:3.1.11.5] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
EIF1, SUI1; translation initiation factor 1 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
K06973; uncharacterized protein 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
K07043; uncharacterized protein 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
K07150; uncharacterized protein 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
marC; multiple antibiotic resistance protein 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
mbtN, fadE14; acyl-ACP dehydrogenase [EC:1.3.99.-] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
mepS, spr; murein DD-endopeptidase / murein LD-carboxypeptidase [EC:3.4.-.- 3.4.17.13] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
mscS; small conductance mechanosensitive channel 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
pcnB; poly(A) polymerase [EC:2.7.7.19] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
pdxB; erythronate-4-phosphate dehydrogenase [EC:1.1.1.290] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
pdxJ; pyridoxine 5-phosphate synthase [EC:2.6.99.2] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
tpx; thiol peroxidase, atypical 2-Cys peroxiredoxin [EC:1.11.1.15] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
ybaK, ebsC; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-] 0.00179 0.00083 0.00169 0.00010 0.00124 65 0.00186 0.00012 0.00112 93 0.00167 -0.10473 144.116 0.91673 0.93531
eamB; cysteine/O-acetylserine efflux protein 0.00132 0.00076 0.00226 0.00016 0.00159 65 0.00067 0.00004 0.00067 93 0.00172 0.92082 86.965 0.35969 0.47172
K09124; uncharacterized protein 0.00132 0.00076 0.00226 0.00016 0.00159 65 0.00067 0.00004 0.00067 93 0.00172 0.92082 86.965 0.35969 0.47172
tagF; CDP-glycerol glycerophosphotransferase [EC:2.7.8.12] 0.00132 0.00076 0.00226 0.00016 0.00159 65 0.00067 0.00004 0.00067 93 0.00172 0.92082 86.965 0.35969 0.47172
cvrA, nhaP2; cell volume regulation protein A 0.00127 0.00090 0.00154 0.00016 0.00154 65 0.00108 0.00011 0.00108 93 0.00188 0.24678 121.612 0.80550 0.86128
hipO; hippurate hydrolase [EC:3.5.1.32] 0.00120 0.00073 0.00145 0.00014 0.00145 65 0.00102 0.00005 0.00072 93 0.00162 0.26278 95.968 0.79328 0.84900
proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2] 0.00099 0.00041 0.00142 0.00004 0.00080 65 0.00069 0.00002 0.00042 93 0.00090 0.80786 99.389 0.42110 0.53882
K07014; uncharacterized protein 0.00093 0.00037 0.00111 0.00003 0.00067 65 0.00080 0.00002 0.00043 93 0.00079 0.39603 114.759 0.69281 0.77590
nosD; nitrous oxidase accessory protein 0.00091 0.00037 0.00111 0.00003 0.00067 65 0.00077 0.00002 0.00043 93 0.00079 0.43147 114.686 0.66694 0.75397
nosF; Cu-processing system ATP-binding protein 0.00091 0.00037 0.00111 0.00003 0.00067 65 0.00077 0.00002 0.00043 93 0.00079 0.43147 114.686 0.66694 0.75397
nosY; Cu-processing system permease protein 0.00091 0.00037 0.00111 0.00003 0.00067 65 0.00077 0.00002 0.00043 93 0.00079 0.43147 114.686 0.66694 0.75397
nosZ; nitrous-oxide reductase [EC:1.7.2.4] 0.00091 0.00037 0.00111 0.00003 0.00067 65 0.00077 0.00002 0.00043 93 0.00079 0.43147 114.686 0.66694 0.75397
ramA; alpha-L-rhamnosidase [EC:3.2.1.40] 0.00091 0.00037 0.00111 0.00003 0.00067 65 0.00077 0.00002 0.00043 93 0.00079 0.43147 114.686 0.66694 0.75397
rnj; ribonuclease J [EC:3.1.-.-] 0.00091 0.00037 0.00111 0.00003 0.00067 65 0.00077 0.00002 0.00043 93 0.00079 0.43147 114.686 0.66694 0.75397
spsF; spore coat polysaccharide biosynthesis protein SpsF 0.00091 0.00037 0.00111 0.00003 0.00067 65 0.00077 0.00002 0.00043 93 0.00079 0.43147 114.686 0.66694 0.75397
dndD; DNA sulfur modification protein DndD 0.00079 0.00062 0.00190 0.00015 0.00151 65 0.00002 0.00000 0.00002 93 0.00151 1.24611 64.021 0.21727 0.35041
res; type III restriction enzyme [EC:3.1.21.5] 0.00078 0.00046 0.00045 0.00001 0.00045 65 0.00100 0.00005 0.00072 93 0.00085 -0.64145 145.970 0.52223 0.62565
E2.4.1.20; cellobiose phosphorylase [EC:2.4.1.20] 0.00072 0.00034 0.00086 0.00002 0.00060 65 0.00062 0.00002 0.00041 93 0.00073 0.33360 118.820 0.73927 0.79783
xylE; MFS transporter, SP family, xylose:H+ symportor 0.00072 0.00034 0.00086 0.00002 0.00060 65 0.00062 0.00002 0.00041 93 0.00073 0.33360 118.820 0.73927 0.79783
citD; citrate lyase subunit gamma (acyl carrier protein) 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34] 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10] 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
citX; holo-ACP synthase [EC:2.7.7.61] 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
dndC; DNA sulfur modification protein DndC 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
dndE; DNA sulfur modification protein DndE 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
elaA; ElaA protein 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
K02481; two-component system, NtrC family, response regulator 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
K07220; uncharacterized protein 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
K07491; putative transposase 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
kdpA; K+-transporting ATPase ATPase A chain [EC:3.6.3.12] 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
kdpB; K+-transporting ATPase ATPase B chain [EC:3.6.3.12] 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
kdpC; K+-transporting ATPase ATPase C chain [EC:3.6.3.12] 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
ltrA; RNA-directed DNA polymerase [EC:2.7.7.49] 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
norB, norC; MFS transporter, DHA2 family, multidrug resistance protein 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
raxB, cvaB; ATP-binding cassette, subfamily B, bacterial RaxB 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
ribB, RIB3; 3,4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12] 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
TC.PIT; inorganic phosphate transporter, PiT family 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
wcaK, amsJ; colanic acid/amylovoran biosynthesis protein 0.00061 0.00059 0.00145 0.00014 0.00145 65 0.00002 0.00000 0.00002 93 0.00145 0.98657 64.023 0.32757 0.43751
dnaC; DNA replication protein DnaC 0.00059 0.00043 0.00000 0.00000 0.00000 65 0.00100 0.00005 0.00072 93 0.00072 -1.38231 92.000 0.17022 0.29333
K06915; uncharacterized protein 0.00059 0.00043 0.00000 0.00000 0.00000 65 0.00100 0.00005 0.00072 93 0.00072 -1.38231 92.000 0.17022 0.29333
K07078; uncharacterized protein 0.00059 0.00043 0.00000 0.00000 0.00000 65 0.00100 0.00005 0.00072 93 0.00072 -1.38231 92.000 0.17022 0.29333
utp; urea transporter 0.00059 0.00043 0.00000 0.00000 0.00000 65 0.00100 0.00005 0.00072 93 0.00072 -1.38231 92.000 0.17022 0.29333
cytR; LacI family transcriptional regulator, repressor for deo operon, udp, cdd, tsx, nupC, and nupG 0.00053 0.00029 0.00041 0.00001 0.00041 65 0.00062 0.00002 0.00041 93 0.00058 -0.36408 151.355 0.71631 0.79489
GBA, srfJ; glucosylceramidase [EC:3.2.1.45] 0.00053 0.00029 0.00041 0.00001 0.00041 65 0.00062 0.00002 0.00041 93 0.00058 -0.36408 151.355 0.71631 0.79489
K09973; uncharacterized protein 0.00053 0.00029 0.00041 0.00001 0.00041 65 0.00062 0.00002 0.00041 93 0.00058 -0.36408 151.355 0.71631 0.79489
amt, AMT, MEP; ammonium transporter, Amt family 0.00037 0.00037 0.00091 0.00005 0.00091 65 0.00000 0.00000 0.00000 93 0.00091 1.00000 64.000 0.32108 0.43751
ABC.PA.S; polar amino acid transport system substrate-binding protein 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
asnB, ASNS; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4] 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
CS, gltA; citrate synthase [EC:2.3.3.1] 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
cysH; phosphoadenosine phosphosulfate reductase [EC:1.8.4.8 1.8.4.10] 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
czcB; membrane fusion protein, cobalt-zinc-cadmium efflux system 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
DNPEP; aspartyl aminopeptidase [EC:3.4.11.21] 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
E3.2.1.4; endoglucanase [EC:3.2.1.4] 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
E3.2.1.8, xynA; endo-1,4-beta-xylanase [EC:3.2.1.8] 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
emrA; membrane fusion protein, multidrug efflux system 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
glnB; nitrogen regulatory protein P-II 1 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
gltB; glutamate synthase (NADPH/NADH) large chain [EC:1.4.1.13 1.4.1.14] 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
gmhA, lpcA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28] 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83] 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
hddA; D-glycero-alpha-D-manno-heptose-7-phosphate kinase [EC:2.7.1.168] 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
K07166; ACT domain-containing protein 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
K07484; transposase 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
K09157; uncharacterized protein 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
K09922; uncharacterized protein 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
modF; molybdate transport system ATP-binding protein 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
nhaC; Na+:H+ antiporter, NhaC family 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
pip; proline iminopeptidase [EC:3.4.11.5] 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41] 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
proB; glutamate 5-kinase [EC:2.7.2.11] 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
rnfA; electron transport complex protein RnfA 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
rnfC; electron transport complex protein RnfC 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
rnfD; electron transport complex protein RnfD 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
rnfE; electron transport complex protein RnfE 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
rseC; sigma-E factor negative regulatory protein RseC 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
thiG; thiazole synthase [EC:2.8.1.10] 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
thiH; 2-iminoacetate synthase [EC:4.1.99.19] 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
thiS; sulfur carrier protein 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751
yaeR; glyoxylase I family protein 0.00019 0.00019 0.00045 0.00001 0.00045 65 0.00000 0.00000 0.00000 93 0.00045 1.00000 64.000 0.32108 0.43751 
plot.dat <- tb.ra %>%
  arrange(desc(`Overall Mean`)) %>%
  slice_head(n=50)%>%
  mutate(
    description = fct_reorder(description, `Overall Mean`),
    description = factor(description, levels = levels(description), ordered=T)
  ) %>%
  arrange(description) %>%
  mutate(
    id = 1:n(),
    step = ifelse(id%%2 == 0, 1, 0),
    Mean_diff = `Tumor Mean` - `Non-Tumor Mean`,
    diff_se = SEpooled,
    Mean_diff_ll = Mean_diff - qt(0.975, df)*diff_se,
    Mean_diff_ul = Mean_diff + qt(0.975, df)*diff_se
  ) %>%
  pivot_longer(
    cols=contains("Mean"),
    names_to = "group",
    values_to = "mean"
  )



p1.d <- plot.dat %>%
  filter(group %in% c("Tumor Mean","Non-Tumor Mean")) %>%
  mutate(
    group = ifelse(group == "Tumor Mean", "Tumor", "Non-Tumor"),
    col = ifelse(step == 1, "grey90", "white"),
    h=1, w=Inf
    
  )
p1 <- ggplot()+
  geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_bar(data=p1.d,
             aes(x=mean, y=description,
                 group=group, color=group,
                 fill=group),
             stat="identity",position = "dodge",
             alpha = 1)+
    labs(x="Mean RelAbundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      plot.margin = unit(c(1,0,1,1), "lines")
    )

p2.d <- plot.dat %>%
  filter(group %in% c("Mean_diff", "Mean_diff_ll", "Mean_diff_ul")) %>%
  pivot_wider(
    names_from = group,
    values_from = mean
  ) %>%
  mutate(
    group = ifelse(Mean_diff > 0, "Tumor", "Non-Tumor"),
    p = sprintf("%.3f", round(p,3)),
    ll = min(Mean_diff_ll)-0.01,
    ul = max(Mean_diff_ul)+0.01
  )
p2<-ggplot(p2.d, aes(x=Mean_diff, y=description))+
    geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_vline(xintercept = 0, linetype="dashed", alpha=0.5)+
    geom_segment(aes(x=Mean_diff_ll, y=description, xend=Mean_diff_ul, yend=description))+
    geom_point(aes(fill=group, color=group))+
    geom_text(aes(label=p, x=unique(ul)+0.1))+
    coord_cartesian(xlim = c(unique(p2.d$ll), unique(p2.d$ul)),
                    clip = 'off') +
    annotate("text", x=unique(p2.d$ul)+0.2,y = 25,
             angle=90,
             label="p-value (uncorrected)")+
    labs(x="Mean Difference in RelAbundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      axis.title.y = element_blank(),
      axis.text.y = element_blank(),
      axis.line.y = element_blank(),
      axis.ticks.y = element_blank(),
      plot.margin = unit(c(1,4,1,0), "lines")
    )

# plot
p1 + p2 +
  plot_annotation(title="Stratefied KO Data - Prevotella spp. (genus level only): 50 most abundant descriptions")

Modeling Difference between Tumor and Non-Tumor

For the modeling, we used a generalized linear mixed model (GLMM).

First, we looked at the biserial correlation between the abundance of each description and the tumor status.

tb <- mydata %>%
  group_by(description)%>%
  summarise(
    r = cor(tumor, Abundance)
  ) %>%
  mutate(
    M=mean(r)
  )

ggplot(tb, aes(x=r))+
  geom_density()+
  geom_vline(aes(xintercept = M))+
  labs(x="Biserial Correlation",title="Relationship between description abundance and tumor (tumor vs. non-tumor)")+
  theme(panel.grid = element_blank())

Next, we need the data to be on an interpretable scale. First, let’s use the raw abundance like scale.

p <- ggplot(mydata, aes(x=Abundance))+
  geom_density()
p

mydata <- mydata %>%
  mutate(Abundance.dich=ifelse(Abundance==0, 0, 1))
table(mydata$Abundance.dich)

     0      1 
 80642 102322

Let’s first run models by description so that we can avoid the nesting issue initially. We will come back to this to conduct the final model (it will be more powerful).

DESCRIPTIONS <- unique(mydata$description)
i<-1
dat0 <- mydata %>% filter(description==DESCRIPTIONS[i])

# quasipossion (approximately negative binom) give an approx. answer.
fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
summary(fit0)

Call:
glm(formula = Abundance ~ 1 + tumor, family = quasipoisson(link = "log"), 
    data = dat0)

Deviance Residuals: 
   Min      1Q  Median      3Q     Max  
 -7.50   -6.68   -4.88    1.25   29.69  

Coefficients:
            Estimate Std. Error t value Pr(>|t|)    
(Intercept)    3.336      0.177   18.85   <2e-16 ***
tumor         -0.230      0.296   -0.78     0.44    
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for quasipoisson family taken to be 81.936)

    Null deviance: 8507.2  on 157  degrees of freedom
Residual deviance: 8456.6  on 156  degrees of freedom
AIC: NA

Number of Fisher Scoring iterations: 6

NExt, let’s model the percent relative abundance. This will allow us to make inference about the difference average relative abundance. Which is a simpler interpretation than trying to model differences in the log relative abundance which will need to be interpreted as the multiplicative relative change.

results.out <- as.data.frame(matrix(ncol=4, nrow=length(DESCRIPTIONS)))
colnames(results.out) <- c("description", "Est", "SE", "p")
#results.out$description <-DESCRIPTIONS

i <- 1
for(i in 1:length(DESCRIPTIONS)){
#for(i in 1:5){ 
  dat0 <- mydata %>%
    filter(description == DESCRIPTIONS[i])
  fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
  fit.sum <- summary(fit0)
  results.out[i, 1] <- DESCRIPTIONS[i]
  results.out[i, 2:4] <- fit.sum$coefficients[2, c(1,2,4)]
}

results.out$fdr_p <- p.adjust(results.out$p, method="fdr")

kable(results.out, format="html", digits=3) %>%
  kable_styling(full_width = T)%>%
  scroll_box(width="100%", height="600px")
description Est SE p fdr_p
AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7] -0.230 0.296 0.438 0.651
aat; leucyl/phenylalanyl-tRNA—protein transferase [EC:2.3.2.6] 0.056 0.493 0.910 0.976
ABC-2.A; ABC-2 type transport system ATP-binding protein -0.287 0.311 0.357 0.651
ABC-2.OM, wza; polysaccharide biosynthesis/export protein -0.285 0.310 0.360 0.651
ABC-2.P; ABC-2 type transport system permease protein -0.263 0.312 0.401 0.651
ABC-2.TX; HlyD family secretion protein -0.249 0.304 0.415 0.651
ABC.CD.A; putative ABC transport system ATP-binding protein -0.616 0.516 0.234 0.651
ABC.CD.P; putative ABC transport system permease protein -0.642 0.523 0.221 0.651
ABC.CD.TX; HlyD family secretion protein -0.566 0.561 0.314 0.651
ABC.FEV.A; iron complex transport system ATP-binding protein [EC:3.6.3.34] -0.230 0.296 0.438 0.651
ABC.FEV.P; iron complex transport system permease protein -0.230 0.296 0.438 0.651
ABC.FEV.S; iron complex transport system substrate-binding protein -0.230 0.296 0.438 0.651
ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:3.6.3.21] -2.168 1.874 0.249 0.651
ABC.PA.S; polar amino acid transport system substrate-binding protein 18.519 3411.091 0.996 0.998
ABC.SN.S; NitT/TauT family transport system substrate-binding protein -0.230 0.296 0.438 0.651
ABC.X2.A; putative ABC transport system ATP-binding protein -1.649 1.326 0.215 0.651
ABC.X2.P; putative ABC transport system permease protein -0.521 0.433 0.230 0.651
ABCB-BAC; ATP-binding cassette, subfamily B, bacterial -0.288 0.314 0.360 0.651
ABCF3; ATP-binding cassette, subfamily F, member 3 -0.230 0.296 0.438 0.651
abfA; alpha-N-arabinofuranosidase [EC:3.2.1.55] -0.691 0.615 0.263 0.651
abgT; aminobenzoyl-glutamate transport protein -0.123 0.313 0.694 0.797
abnA; arabinan endo-1,5-alpha-L-arabinosidase [EC:3.2.1.99] -0.573 0.507 0.260 0.651
ackA; acetate kinase [EC:2.7.2.1] -0.230 0.296 0.438 0.651
acm; lysozyme -0.207 0.296 0.486 0.651
ACO, acnA; aconitate hydratase [EC:4.2.1.3] -0.429 1.387 0.758 0.843
acpP; acyl carrier protein -0.367 0.318 0.251 0.651
acrA, mexA, adeI, smeD, mtrC, cmeA; membrane fusion protein, multidrug efflux system -0.216 0.278 0.438 0.651
ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3] -0.247 0.302 0.414 0.651
ACSS, acs; acetyl-CoA synthetase [EC:6.2.1.1] -0.203 0.301 0.500 0.651
ada; AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC:2.1.1.63] -0.626 0.575 0.278 0.651
adk, AK; adenylate kinase [EC:2.7.4.3] -0.230 0.296 0.438 0.651
agaR; DeoR family transcriptional regulator, aga operon transcriptional repressor -0.731 0.848 0.390 0.651
agp; glucose-1-phosphatase [EC:3.1.3.10] -0.072 0.305 0.815 0.896
aguA; alpha-glucuronidase [EC:3.2.1.139] -0.788 0.881 0.373 0.651
aguB; N-carbamoylputrescine amidase [EC:3.5.1.53] -0.230 0.296 0.438 0.651
ahpF; alkyl hydroperoxide reductase subunit F [EC:1.6.4.-] -0.120 0.315 0.704 0.799
AIBP, nnrE; NAD(P)H-hydrate epimerase [EC:5.1.99.6] -0.230 0.296 0.438 0.651
ald; alanine dehydrogenase [EC:1.4.1.1] -0.647 0.554 0.244 0.651
algI; alginate O-acetyltransferase complex protein AlgI -0.221 0.572 0.699 0.797
alr; alanine racemase [EC:5.1.1.1] -0.230 0.296 0.438 0.651
amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] -0.230 0.296 0.438 0.651
amn; AMP nucleosidase [EC:3.2.2.4] -0.754 1.120 0.502 0.651
ampG; MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG -0.211 0.297 0.479 0.651
amt, AMT, MEP; ammonium transporter, Amt family 18.212 2925.911 0.995 0.998
AMY, amyA, malS; alpha-amylase [EC:3.2.1.1] -0.270 0.303 0.374 0.651
apbE; FAD:protein FMN transferase [EC:2.7.1.180] -0.230 0.296 0.438 0.651
APEX1; AP endonuclease 1 [EC:4.2.99.18] 0.141 0.367 0.701 0.797
apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12] -0.606 0.561 0.282 0.651
APRT, apt; adenine phosphoribosyltransferase [EC:2.4.2.7] -0.230 0.296 0.438 0.651
aqpZ; aquaporin Z 0.145 0.349 0.679 0.789
araA; L-arabinose isomerase [EC:5.3.1.4] -0.670 0.642 0.298 0.651
araD, ulaF, sgaE, sgbE; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4] -0.670 0.642 0.298 0.651
argB; acetylglutamate kinase [EC:2.7.2.8] -0.100 1.127 0.930 0.976
argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38] -0.100 1.127 0.930 0.976
argE; acetylornithine deacetylase [EC:3.5.1.16] -0.100 1.127 0.930 0.976
argF; N-succinyl-L-ornithine transcarbamylase [EC:2.1.3.11] -0.100 1.127 0.930 0.976
argG, ASS1; argininosuccinate synthase [EC:6.3.4.5] -0.100 1.127 0.930 0.976
argH, ASL; argininosuccinate lyase [EC:4.3.2.1] -0.100 1.127 0.930 0.976
argR, ahrC; transcriptional regulator of arginine metabolism -0.230 0.296 0.438 0.651
arnE; undecaprenyl phosphate-alpha-L-ara4N flippase subunit ArnE -0.685 0.544 0.210 0.651
aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19] -0.230 0.296 0.438 0.651
AROA1, aroA; chorismate mutase [EC:5.4.99.5] -0.230 0.296 0.438 0.651
aroB; 3-dehydroquinate synthase [EC:4.2.3.4] -0.230 0.296 0.438 0.651
aroC; chorismate synthase [EC:4.2.3.5] -0.230 0.296 0.438 0.651
aroE; shikimate dehydrogenase [EC:1.1.1.25] -0.230 0.296 0.438 0.651
aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10] -0.230 0.296 0.438 0.651
asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11] -0.230 0.296 0.438 0.651
asnA; aspartate–ammonia ligase [EC:6.3.1.1] -0.213 0.293 0.468 0.651
asnB, ASNS; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4] 18.519 3411.091 0.996 0.998
asnC; Lrp/AsnC family transcriptional regulator, regulator for asnA, asnC and gidA -0.241 0.306 0.433 0.651
aspA; aspartate ammonia-lyase [EC:4.3.1.1] -0.259 0.322 0.423 0.651
aspB; aspartate aminotransferase [EC:2.6.1.1] -0.235 0.289 0.416 0.651
aspS; aspartyl-tRNA synthetase [EC:6.1.1.12] -0.230 0.296 0.438 0.651
ATOX1, ATX1, copZ, golB; copper chaperone -0.242 0.322 0.454 0.651
ATPF0A, atpB; F-type H+-transporting ATPase subunit a -0.230 0.296 0.438 0.651
ATPF0B, atpF; F-type H+-transporting ATPase subunit b -0.230 0.296 0.438 0.651
ATPF0C, atpE; F-type H+-transporting ATPase subunit c -0.230 0.296 0.438 0.651
ATPF1A, atpA; F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14] -0.244 0.294 0.409 0.651
ATPF1B, atpD; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14] -0.230 0.296 0.438 0.651
ATPF1D, atpH; F-type H+-transporting ATPase subunit delta -0.230 0.296 0.438 0.651
ATPF1E, atpC; F-type H+-transporting ATPase subunit epsilon -0.230 0.296 0.438 0.651
ATPF1G, atpG; F-type H+-transporting ATPase subunit gamma -0.230 0.296 0.438 0.651
AXY8, FUC95A, afcA; alpha-L-fucosidase 2 [EC:3.2.1.51] -0.161 0.278 0.562 0.689
bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] -0.230 0.296 0.438 0.651
bamD; outer membrane protein assembly factor BamD -0.230 0.296 0.438 0.651
BCP, PRXQ, DOT5; peroxiredoxin Q/BCP [EC:1.11.1.15] -0.230 0.296 0.438 0.651
bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] -0.309 0.308 0.317 0.651
bdhAB; butanol dehydrogenase [EC:1.1.1.-] -0.746 1.115 0.505 0.651
bgaB, lacA; beta-galactosidase [EC:3.2.1.23] -0.671 0.462 0.148 0.651
bglX; beta-glucosidase [EC:3.2.1.21] -0.399 0.427 0.352 0.651
bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47] -0.754 1.120 0.502 0.651
birA; BirA family transcriptional regulator, biotin operon repressor / biotin—[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] -0.230 0.296 0.438 0.651
BLMH, pepC; bleomycin hydrolase [EC:3.4.22.40] -0.224 0.296 0.452 0.651
bshA; L-malate glycosyltransferase [EC:2.4.1.-] -2.232 1.933 0.250 0.651
buk; butyrate kinase [EC:2.7.2.7] -0.147 0.329 0.655 0.768
capA, pgsA; gamma-polyglutamate biosynthesis protein CapA -0.117 0.336 0.728 0.823
carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5] -0.230 0.296 0.438 0.651
carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5] -0.232 0.301 0.441 0.651
CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16] -0.230 0.296 0.438 0.651
cas1; CRISP-associated protein Cas1 -0.588 0.445 0.188 0.651
cas2; CRISPR-associated protein Cas2 -0.588 0.445 0.188 0.651
cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 3.6.4.-] -0.789 0.881 0.372 0.651
cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1] -0.789 0.881 0.372 0.651
cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-] -0.677 0.652 0.301 0.651
cbe, mbe; cellobiose epimerase [EC:5.1.3.11] -0.588 0.587 0.318 0.651
cbpA; curved DNA-binding protein -0.231 0.318 0.469 0.651
ccrM; modification methylase [EC:2.1.1.72] -0.297 0.684 0.664 0.776
cdd, CDA; cytidine deaminase [EC:3.5.4.5] -0.230 0.296 0.438 0.651
CHO1, pssA; CDP-diacylglycerol—serine O-phosphatidyltransferase [EC:2.7.8.8] -0.230 0.296 0.438 0.651
chrA; chromate transporter -0.220 0.299 0.463 0.651
cidA; holin-like protein -0.110 0.293 0.709 0.803
cimA; (R)-citramalate synthase [EC:2.3.1.182] -0.100 1.127 0.930 0.976
citD; citrate lyase subunit gamma (acyl carrier protein) 2.304 1.989 0.248 0.651
citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34] 2.304 1.989 0.248 0.651
citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10] 2.304 1.989 0.248 0.651
citX; holo-ACP synthase [EC:2.7.7.61] 2.304 1.989 0.248 0.651
clpA; ATP-dependent Clp protease ATP-binding subunit ClpA 0.056 0.493 0.910 0.976
clpB; ATP-dependent Clp protease ATP-binding subunit ClpB -0.230 0.296 0.438 0.651
clpC; ATP-dependent Clp protease ATP-binding subunit ClpC -0.230 0.296 0.438 0.651
clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] -0.230 0.296 0.438 0.651
clpS; ATP-dependent Clp protease adaptor protein ClpS 0.056 0.493 0.910 0.976
clpX, CLPX; ATP-dependent Clp protease ATP-binding subunit ClpX -0.230 0.296 0.438 0.651
clsA_B; cardiolipin synthase A/B [EC:2.7.8.-] -0.230 0.296 0.438 0.651
cmk; CMP/dCMP kinase [EC:2.7.4.25] -0.230 0.296 0.438 0.651
coaBC, dfp; phosphopantothenoylcysteine decarboxylase / phosphopantothenate—cysteine ligase [EC:4.1.1.36 6.3.2.5] -0.213 0.298 0.477 0.651
coaE; dephospho-CoA kinase [EC:2.7.1.24] -0.228 0.308 0.459 0.651
coaW; type II pantothenate kinase [EC:2.7.1.33] -0.219 0.301 0.468 0.651
coaX; type III pantothenate kinase [EC:2.7.1.33] -0.754 1.120 0.502 0.651
cobA, btuR; cob(I)alamin adenosyltransferase [EC:2.5.1.17] -0.221 0.572 0.699 0.797
cobC, phpB; alpha-ribazole phosphatase [EC:3.1.3.73] -0.680 0.538 0.208 0.651
cobN; cobaltochelatase CobN [EC:6.6.1.2] -0.341 0.419 0.416 0.651
cobP, cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62] -0.680 0.538 0.208 0.651
comEB; dCMP deaminase [EC:3.5.4.12] -0.230 0.296 0.438 0.651
comEC; competence protein ComEC -0.230 0.296 0.438 0.651
comM; magnesium chelatase family protein -0.243 0.294 0.409 0.651
copB; Cu2+-exporting ATPase [EC:3.6.3.4] -0.224 0.285 0.434 0.651
corA; magnesium transporter -0.230 0.296 0.438 0.651
cpdB; 2’,3’-cyclic-nucleotide 2’-phosphodiesterase / 3’-nucleotidase [EC:3.1.4.16 3.1.3.6] -0.285 0.310 0.360 0.651
crcB, FEX; fluoride exporter -0.239 0.315 0.449 0.651
CS, gltA; citrate synthase [EC:2.3.3.1] 18.519 3411.091 0.996 0.998
csm1, cas10; CRISPR-associated protein Csm1 -1.447 1.576 0.360 0.651
csm2; CRISPR-associated protein Csm2 -1.447 1.576 0.360 0.651
csm3; CRISPR-associated protein Csm3 -1.447 1.576 0.360 0.651
csn1, cas9; CRISPR-associated endonuclease Csn1 [EC:3.1.-.-] -0.460 0.462 0.321 0.651
csxA; exo-1,4-beta-D-glucosaminidase [EC:3.2.1.165] -2.232 1.933 0.250 0.651
cusA, silA; Cu(I)/Ag(I) efflux system membrane protein CusA/SilA 0.153 0.466 0.742 0.834
cusB, silB; membrane fusion protein, Cu(I)/Ag(I) efflux system 0.045 0.522 0.932 0.976
cutC; copper homeostasis protein -0.277 0.305 0.364 0.651
cvrA, nhaP2; cell volume regulation protein A -1.146 1.935 0.555 0.683
cydA; cytochrome bd ubiquinol oxidase subunit I [EC:1.10.3.14] -0.230 0.296 0.438 0.651
cydB; cytochrome bd ubiquinol oxidase subunit II [EC:1.10.3.14] -0.230 0.296 0.438 0.651
cynR; LysR family transcriptional regulator, cyn operon transcriptional activator -0.330 0.504 0.514 0.651
cynT, can; carbonic anhydrase [EC:4.2.1.1] -0.169 0.333 0.614 0.731
cysC; adenylylsulfate kinase [EC:2.7.1.25] -0.754 1.120 0.502 0.651
cysD; sulfate adenylyltransferase subunit 2 [EC:2.7.7.4] -0.754 1.120 0.502 0.651
cysE; serine O-acetyltransferase [EC:2.3.1.30] -0.157 0.290 0.590 0.717
cysH; phosphoadenosine phosphosulfate reductase [EC:1.8.4.8 1.8.4.10] 18.519 3411.091 0.996 0.998
cysK; cysteine synthase A [EC:2.5.1.47] -0.260 0.313 0.407 0.651
cysN; sulfate adenylyltransferase subunit 1 [EC:2.7.7.4] -0.754 1.120 0.502 0.651
cysQ, MET22, BPNT1; 3’(2’), 5’-bisphosphate nucleotidase [EC:3.1.3.7] -0.754 1.120 0.502 0.651
cytR; LacI family transcriptional regulator, repressor for deo operon, udp, cdd, tsx, nupC, and nupG 0.151 1.352 0.911 0.976
czcA; cobalt-zinc-cadmium resistance protein CzcA 0.470 0.526 0.372 0.651
czcB; membrane fusion protein, cobalt-zinc-cadmium efflux system 18.519 3411.091 0.996 0.998
dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-] -0.288 0.314 0.360 0.651
dam; DNA adenine methylase [EC:2.1.1.72] -0.174 0.353 0.623 0.740
dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7] -0.230 0.296 0.438 0.651
dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8] -0.230 0.296 0.438 0.651
dapdh; diaminopimelate dehydrogenase [EC:1.4.1.16] -0.228 0.293 0.436 0.651
dapF; diaminopimelate epimerase [EC:5.1.1.7] -0.394 0.395 0.320 0.651
dcp; peptidyl-dipeptidase Dcp [EC:3.4.15.5] -0.233 0.311 0.453 0.651
dcuA; anaerobic C4-dicarboxylate transporter DcuA -0.318 0.477 0.505 0.651
dcuB; anaerobic C4-dicarboxylate transporter DcuB -0.221 0.572 0.699 0.797
ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] -0.230 0.296 0.438 0.651
deaD, cshA; ATP-dependent RNA helicase DeaD [EC:3.6.4.13] -0.230 0.296 0.438 0.651
deoC, DERA; deoxyribose-phosphate aldolase [EC:4.1.2.4] -0.230 0.296 0.438 0.651
dexA; dextranase [EC:3.2.1.11] -0.282 0.509 0.580 0.706
dfx; superoxide reductase [EC:1.15.1.2] -0.166 0.321 0.605 0.723
dgt; dGTPase [EC:3.1.5.1] -0.230 0.296 0.438 0.651
DHFR, folA; dihydrofolate reductase [EC:1.5.1.3] -0.201 0.284 0.481 0.651
dinB; DNA polymerase IV [EC:2.7.7.7] -0.230 0.296 0.438 0.651
dinD; DNA-damage-inducible protein D -0.195 0.637 0.759 0.844
djlA; DnaJ like chaperone protein -0.174 0.327 0.596 0.722
DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4] -0.190 0.321 0.556 0.683
dnaA; chromosomal replication initiator protein -0.230 0.296 0.438 0.651
dnaB; replicative DNA helicase [EC:3.6.4.12] -0.230 0.296 0.438 0.651
dnaC; DNA replication protein DnaC -17.599 3454.822 0.996 0.998
dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] -0.230 0.296 0.438 0.651
dnaG; DNA primase [EC:2.7.7.-] -0.230 0.296 0.438 0.651
dnaJ; molecular chaperone DnaJ -0.230 0.296 0.438 0.651
dnaK, HSPA9; molecular chaperone DnaK -0.230 0.296 0.438 0.651
dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] -0.230 0.296 0.438 0.651
dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] -0.218 0.290 0.455 0.651
dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] -0.230 0.296 0.438 0.651
dndC; DNA sulfur modification protein DndC 2.304 1.989 0.248 0.651
dndD; DNA sulfur modification protein DndD 2.332 1.962 0.236 0.651
dndE; DNA sulfur modification protein DndE 2.304 1.989 0.248 0.651
DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] -0.244 0.306 0.427 0.651
DNPEP; aspartyl aminopeptidase [EC:3.4.11.21] 18.519 3411.091 0.996 0.998
DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83] -0.230 0.296 0.438 0.651
dpo; DNA polymerase bacteriophage-type [EC:2.7.7.7] 0.358 0.550 0.516 0.651
DPP3; dipeptidyl-peptidase III [EC:3.4.14.4] -0.230 0.296 0.438 0.651
DPP4, CD26; dipeptidyl-peptidase 4 [EC:3.4.14.5] -0.230 0.296 0.438 0.651
dps; starvation-inducible DNA-binding protein -0.222 0.303 0.464 0.651
dsbD; thiol:disulfide interchange protein DsbD [EC:1.8.1.8] -0.230 0.296 0.438 0.651
dtd, DTD1; D-tyrosyl-tRNA(Tyr) deacylase [EC:3.1.-.-] -0.230 0.296 0.438 0.651
dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23] -0.230 0.296 0.438 0.651
dxr; 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267] -0.230 0.296 0.438 0.651
dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7] -0.211 0.305 0.489 0.651
E1.1.1.40, maeB; malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) [EC:1.1.1.40] -0.230 0.296 0.438 0.651
E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] -0.178 0.295 0.546 0.680
E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] -0.123 0.286 0.667 0.778
E1.4.1.4, gdhA; glutamate dehydrogenase (NADP+) [EC:1.4.1.4] -0.154 0.290 0.596 0.722
E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72] -0.359 0.322 0.266 0.651
E2.1.1.77, pcm; protein-L-isoaspartate(D-aspartate) O-methyltransferase [EC:2.1.1.77] -0.137 0.613 0.823 0.900
E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1] -0.234 0.306 0.446 0.651
E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6] -0.548 0.584 0.350 0.651
E2.2.1.6S, ilvH, ilvN; acetolactate synthase I/III small subunit [EC:2.2.1.6] -0.548 0.584 0.350 0.651
E2.3.1.54, pflD; formate C-acetyltransferase [EC:2.3.1.54] -0.215 0.295 0.468 0.651
E2.3.1.8, pta; phosphate acetyltransferase [EC:2.3.1.8] -0.230 0.296 0.438 0.651
E2.4.1.20; cellobiose phosphorylase [EC:2.4.1.20] 0.154 1.349 0.909 0.976
E2.4.2.21, cobU, cobT; nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21] -0.680 0.538 0.208 0.651
E2.5.1.56, neuB; N-acetylneuraminate synthase [EC:2.5.1.56] -2.232 1.933 0.250 0.651
E2.6.1.11, argD; acetylornithine aminotransferase [EC:2.6.1.11] -0.100 1.127 0.930 0.976
E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42] -0.230 0.296 0.438 0.651
E2.6.1.83; LL-diaminopimelate aminotransferase [EC:2.6.1.83] -0.394 0.395 0.320 0.651
E2.7.1.4, scrK; fructokinase [EC:2.7.1.4] -0.239 0.302 0.431 0.651
E2.7.1.71, aroK, aroL; shikimate kinase [EC:2.7.1.71] -0.230 0.296 0.438 0.651
E2.7.4.8, gmk; guanylate kinase [EC:2.7.4.8] -0.230 0.296 0.438 0.651
E2.7.7.24, rfbA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] -0.230 0.296 0.438 0.651
E2.7.7.3A, coaD, kdtB; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3] -0.230 0.296 0.438 0.651
E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41] -0.230 0.296 0.438 0.651
E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26] -0.680 0.538 0.208 0.651
E3.1.1.11; pectinesterase [EC:3.1.1.11] -0.674 0.651 0.302 0.651
E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2] -0.138 0.295 0.642 0.755
E3.1.11.5; exodeoxyribonuclease V [EC:3.1.11.5] -0.754 1.120 0.502 0.651
E3.1.21.4; type II restriction enzyme [EC:3.1.21.4] -0.343 0.461 0.459 0.651
E3.1.3.1, phoA, phoB; alkaline phosphatase [EC:3.1.3.1] -0.400 0.466 0.392 0.651
E3.1.3.48; protein-tyrosine phosphatase [EC:3.1.3.48] -0.237 0.301 0.432 0.651
E3.1.3.5; 5’-nucleotidase [EC:3.1.3.5] -0.219 0.301 0.468 0.651
E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46] -0.647 0.496 0.194 0.651
E3.1.6.1, aslA; arylsulfatase [EC:3.1.6.1] -0.131 0.339 0.701 0.797
E3.2.1.17; lysozyme [EC:3.2.1.17] 0.038 0.447 0.932 0.976
E3.2.1.1A; alpha-amylase [EC:3.2.1.1] -0.230 0.296 0.438 0.651
E3.2.1.22B, galA, rafA; alpha-galactosidase [EC:3.2.1.22] -0.168 0.287 0.561 0.689
E3.2.1.4; endoglucanase [EC:3.2.1.4] 18.519 3411.091 0.996 0.998
E3.2.1.8, xynA; endo-1,4-beta-xylanase [EC:3.2.1.8] 18.519 3411.091 0.996 0.998
E3.2.1.89; arabinogalactan endo-1,4-beta-galactosidase [EC:3.2.1.89] -0.483 0.529 0.363 0.651
E3.4.21.102, prc, ctpA; carboxyl-terminal processing protease [EC:3.4.21.102] -0.230 0.296 0.438 0.651
E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1] -0.260 0.336 0.441 0.651
E3.5.2.10; creatinine amidohydrolase [EC:3.5.2.10] -2.232 1.933 0.250 0.651
E3.6.1.22, NUDT12, nudC; NAD+ diphosphatase [EC:3.6.1.22] -0.230 0.296 0.438 0.651
E3.6.3.8; Ca2+-transporting ATPase [EC:3.6.3.8] -0.156 0.300 0.605 0.723
E4.1.1.49, pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49] -0.230 0.296 0.438 0.651
E4.1.3.3, nanA, NPL; N-acetylneuraminate lyase [EC:4.1.3.3] -0.206 0.295 0.486 0.651
E4.2.1.2A, fumA, fumB; fumarate hydratase, class I [EC:4.2.1.2] -0.230 0.296 0.438 0.651
E4.2.1.2AA, fumA; fumarate hydratase subunit alpha [EC:4.2.1.2] -0.221 0.572 0.699 0.797
E4.2.1.2AB, fumB; fumarate hydratase subunit beta [EC:4.2.1.2] -0.221 0.572 0.699 0.797
E4.2.1.46, rfbB, rffG; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] -0.230 0.296 0.438 0.651
E4.3.1.17, sdaA, sdaB, tdcG; L-serine dehydratase [EC:4.3.1.17] -0.230 0.296 0.438 0.651
E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19] -0.378 0.462 0.414 0.651
E5.1.3.6; UDP-glucuronate 4-epimerase [EC:5.1.3.6] -0.057 0.574 0.921 0.976
E5.2.1.8; peptidylprolyl isomerase [EC:5.2.1.8] -0.080 0.342 0.815 0.896
E6.3.5.1, NADSYN1, QNS1, nadE; NAD+ synthase (glutamine-hydrolysing) [EC:6.3.5.1] -0.230 0.296 0.438 0.651
E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2] -0.230 0.296 0.438 0.651
eamB; cysteine/O-acetylserine efflux protein 0.092 1.404 0.948 0.986
EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17] -0.230 0.296 0.438 0.651
eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] -0.628 0.582 0.282 0.651
efp; elongation factor P -0.230 0.296 0.438 0.651
EIF1, SUI1; translation initiation factor 1 -0.754 1.120 0.502 0.651
elaA; ElaA protein 2.304 1.989 0.248 0.651
emrA; membrane fusion protein, multidrug efflux system 18.519 3411.091 0.996 0.998
ENDOG; endonuclease G, mitochondrial -0.199 0.305 0.515 0.651
engA, der; GTPase -0.230 0.296 0.438 0.651
engB; GTP-binding protein -0.230 0.296 0.438 0.651
ENO, eno; enolase [EC:4.2.1.11] -0.230 0.296 0.438 0.651
entC; isochorismate synthase [EC:5.4.4.2] -0.230 0.296 0.438 0.651
epsD; glycosyltransferase EpsD [EC:2.4.-.-] 0.358 0.550 0.516 0.651
eptC; heptose-I-phosphate ethanolaminephosphotransferase [EC:2.7.8.-] -0.236 0.284 0.407 0.651
era, ERAL1; GTPase -0.230 0.296 0.438 0.651
ermC, ermA; 23S rRNA (adenine-N6)-dimethyltransferase [EC:2.1.1.184] 0.141 0.367 0.701 0.797
exbB; biopolymer transport protein ExbB -0.225 0.298 0.452 0.651
exuT; MFS transporter, ACS family, hexuronate transporter -0.692 0.616 0.263 0.651
fabB; 3-oxoacyl-[acyl-carrier-protein] synthase I [EC:2.3.1.41] -0.741 0.488 0.131 0.651
fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] -0.230 0.296 0.438 0.651
fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] -0.230 0.296 0.438 0.651
fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] -0.342 0.306 0.265 0.651
fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] -0.223 0.335 0.506 0.651
fabI; enoyl-[acyl-carrier protein] reductase I [EC:1.3.1.9 1.3.1.10] -0.219 0.301 0.468 0.651
fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] -0.741 0.488 0.131 0.651
fadL; long-chain fatty acid transport protein -0.642 0.547 0.242 0.651
FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] -0.230 0.296 0.438 0.651
FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] -0.230 0.296 0.438 0.651
FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] -0.230 0.296 0.438 0.651
fbp3; fructose-1,6-bisphosphatase III [EC:3.1.3.11] -0.230 0.296 0.438 0.651
fecA; Fe(3+) dicitrate transport protein -0.202 0.360 0.576 0.703
feoB; ferrous iron transport protein B -0.214 0.282 0.449 0.651
fes; enterochelin esterase and related enzymes -0.206 0.316 0.516 0.651
fhs; formate–tetrahydrofolate ligase [EC:6.3.4.3] -0.263 0.312 0.401 0.651
fic; cell filamentation protein -0.213 0.305 0.486 0.651
fixA, etfB; electron transfer flavoprotein beta subunit -0.230 0.296 0.438 0.651
fixB, etfA; electron transfer flavoprotein alpha subunit -0.230 0.296 0.438 0.651
fklB; FKBP-type peptidyl-prolyl cis-trans isomerase FklB [EC:5.2.1.8] -0.223 0.293 0.448 0.651
fldA, nifF, isiB; flavodoxin I -0.201 0.284 0.481 0.651
FLOT; flotillin -2.232 1.933 0.250 0.651
folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:4.1.2.25 5.1.99.8 1.13.11.81] -0.230 0.296 0.438 0.651
folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] -0.230 0.296 0.438 0.651
folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] -0.230 0.296 0.438 0.651
folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3] -0.240 0.304 0.431 0.651
folP; dihydropteroate synthase [EC:2.5.1.15] -0.230 0.296 0.438 0.651
frr, MRRF, RRF; ribosome recycling factor -0.230 0.296 0.438 0.651
fruA; fructan beta-fructosidase [EC:3.2.1.80] -0.268 0.313 0.394 0.651
fsr; MFS transporter, FSR family, fosmidomycin resistance protein -0.081 0.335 0.809 0.893
FTCD; glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase [EC:2.1.2.5 4.3.1.4] -0.162 0.333 0.626 0.741
ftnA, ftn; ferritin [EC:1.16.3.2] -0.219 0.301 0.468 0.651
ftsA; cell division protein FtsA -0.230 0.296 0.438 0.651
ftsE; cell division transport system ATP-binding protein -0.230 0.296 0.438 0.651
ftsH, hflB; cell division protease FtsH [EC:3.4.24.-] -0.230 0.296 0.438 0.651
ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4] -0.229 0.320 0.476 0.651
ftsK, spoIIIE; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family -0.230 0.296 0.438 0.651
ftsQ; cell division protein FtsQ -0.230 0.296 0.438 0.651
ftsW, spoVE; cell division protein FtsW -0.230 0.296 0.438 0.651
ftsX; cell division transport system permease protein -0.230 0.296 0.438 0.651
ftsY; fused signal recognition particle receptor -0.230 0.296 0.438 0.651
ftsZ; cell division protein FtsZ -0.241 0.294 0.412 0.651
FUCA; alpha-L-fucosidase [EC:3.2.1.51] -0.246 0.300 0.413 0.651
fucP; MFS transporter, FHS family, L-fucose permease -0.286 0.297 0.338 0.651
fur, zur, furB; Fur family transcriptional regulator, ferric uptake regulator -0.264 0.311 0.398 0.651
fusA, GFM, EFG; elongation factor G -0.230 0.296 0.438 0.651
galE, GALE; UDP-glucose 4-epimerase [EC:5.1.3.2] -0.230 0.296 0.438 0.651
galK; galactokinase [EC:2.7.1.6] -0.224 0.269 0.406 0.651
galM, GALM; aldose 1-epimerase [EC:5.1.3.3] -0.243 0.306 0.429 0.651
GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12] -0.230 0.296 0.438 0.651
GARS, glyS1; glycyl-tRNA synthetase [EC:6.1.1.14] -0.230 0.296 0.438 0.651
GBA, srfJ; glucosylceramidase [EC:3.2.1.45] 0.151 1.352 0.911 0.976
GBE1, glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18] -0.230 0.296 0.438 0.651
GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16] -0.201 0.284 0.481 0.651
gcpE, ispG; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3] -0.230 0.296 0.438 0.651
gcvH, GCSH; glycine cleavage system H protein -0.190 0.321 0.556 0.683
gcvPA; glycine dehydrogenase subunit 1 [EC:1.4.4.2] -0.190 0.321 0.556 0.683
gcvPB; glycine dehydrogenase subunit 2 [EC:1.4.4.2] -0.190 0.321 0.556 0.683
gcvT, AMT; aminomethyltransferase [EC:2.1.2.10] -0.190 0.321 0.556 0.683
GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29] -0.230 0.296 0.438 0.651
gidA, mnmG, MTO1; tRNA uridine 5-carboxymethylaminomethyl modification enzyme -0.230 0.296 0.438 0.651
gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170] -0.230 0.296 0.438 0.651
glf; UDP-galactopyranose mutase [EC:5.4.99.9] -0.337 0.418 0.421 0.651
glgA; starch synthase [EC:2.4.1.21] -0.230 0.296 0.438 0.651
glk; glucokinase [EC:2.7.1.2] -0.268 0.292 0.361 0.651
glmE, mutE, mamB; methylaspartate mutase epsilon subunit [EC:5.4.99.1] -0.221 0.572 0.699 0.797
glmS, GFPT; glucosamine—fructose-6-phosphate aminotransferase (isomerizing) [EC:2.6.1.16] -0.243 0.311 0.436 0.651
glmS, mutS, mamA; methylaspartate mutase sigma subunit [EC:5.4.99.1] -0.221 0.572 0.699 0.797
glnA, GLUL; glutamine synthetase [EC:6.3.1.2] -0.204 0.294 0.489 0.651
glnB; nitrogen regulatory protein P-II 1 18.519 3411.091 0.996 0.998
GLO1, gloA; lactoylglutathione lyase [EC:4.4.1.5] -1.045 0.919 0.257 0.651
glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3] -0.228 0.331 0.492 0.651
glpB; glycerol-3-phosphate dehydrogenase subunit B [EC:1.1.5.3] -0.228 0.331 0.492 0.651
glpC; glycerol-3-phosphate dehydrogenase subunit C [EC:1.1.5.3] -0.228 0.331 0.492 0.651
GLPF; glycerol uptake facilitator protein -0.075 0.341 0.826 0.900
glpK, GK; glycerol kinase [EC:2.7.1.30] -0.075 0.341 0.826 0.900
glpT; MFS transporter, OPA family, glycerol-3-phosphate transporter -0.591 0.565 0.297 0.651
gltB; glutamate synthase (NADPH/NADH) large chain [EC:1.4.1.13 1.4.1.14] 18.519 3411.091 0.996 0.998
gltD; glutamate synthase (NADPH/NADH) small chain [EC:1.4.1.13 1.4.1.14] -0.324 0.318 0.311 0.651
glxK, garK; glycerate 2-kinase [EC:2.7.1.165] -0.206 0.323 0.524 0.659
glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1] -0.230 0.296 0.438 0.651
gmd, GMDS; GDPmannose 4,6-dehydratase [EC:4.2.1.47] -0.230 0.296 0.438 0.651
gmhA, lpcA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28] 18.519 3411.091 0.996 0.998
gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83] 18.519 3411.091 0.996 0.998
gmuG; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78] -0.658 0.589 0.265 0.651
gph; phosphoglycolate phosphatase [EC:3.1.3.18] -0.223 0.280 0.427 0.651
GPI, pgi; glucose-6-phosphate isomerase [EC:5.3.1.9] -0.230 0.296 0.438 0.651
gpmB; probable phosphoglycerate mutase [EC:5.4.2.12] -0.262 0.309 0.398 0.651
gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12] -0.249 0.316 0.432 0.651
gpr; L-glyceraldehyde 3-phosphate reductase [EC:1.1.1.-] 0.179 0.522 0.732 0.826
gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94] -0.230 0.296 0.438 0.651
gpx; glutathione peroxidase [EC:1.11.1.9] -0.203 0.301 0.502 0.651
greA; transcription elongation factor GreA -0.248 0.296 0.404 0.651
groEL, HSPD1; chaperonin GroEL -0.230 0.296 0.438 0.651
groES, HSPE1; chaperonin GroES -0.230 0.296 0.438 0.651
GRPE; molecular chaperone GrpE -0.230 0.296 0.438 0.651
guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] -0.230 0.296 0.438 0.651
gyrA; DNA gyrase subunit A [EC:5.99.1.3] -0.230 0.296 0.438 0.651
gyrB; DNA gyrase subunit B [EC:5.99.1.3] -0.230 0.296 0.438 0.651
HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21] -0.230 0.296 0.438 0.651
hcp; hydroxylamine reductase [EC:1.7.99.1] -0.206 0.301 0.494 0.651
hddA; D-glycero-alpha-D-manno-heptose-7-phosphate kinase [EC:2.7.1.168] 18.519 3411.091 0.996 0.998
hemD, UROS; uroporphyrinogen-III synthase [EC:4.2.1.75] -0.248 0.296 0.403 0.651
hemK, prmC, HEMK; release factor glutamine methyltransferase [EC:2.1.1.297] -0.230 0.296 0.438 0.651
hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3] -0.227 0.294 0.441 0.651
HEXA_B; hexosaminidase [EC:3.2.1.52] -0.212 0.270 0.432 0.651
hflX; GTPase -0.230 0.296 0.438 0.651
higA; HTH-type transcriptional regulator / antitoxin HigA -0.106 0.353 0.765 0.849
higB-1; toxin HigB-1 -2.232 1.933 0.250 0.651
HINT1, hinT, hit; histidine triad (HIT) family protein -0.230 0.296 0.438 0.651
hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1] -0.014 0.330 0.966 0.998
hipO; hippurate hydrolase [EC:3.5.1.32] -1.546 2.070 0.456 0.651
hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16] -0.100 1.127 0.930 0.976
hisB; imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase [EC:4.2.1.19 3.1.3.15] -0.100 1.127 0.930 0.976
hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9] -0.159 0.284 0.576 0.703
hisD; histidinol dehydrogenase [EC:1.1.1.23] -0.100 1.127 0.930 0.976
hisF; cyclase [EC:4.1.3.-] -0.100 1.127 0.930 0.976
hisG; ATP phosphoribosyltransferase [EC:2.4.2.17] -0.100 1.127 0.930 0.976
hisH; glutamine amidotransferase [EC:2.4.2.-] -0.100 1.127 0.930 0.976
hisIE; phosphoribosyl-ATP pyrophosphohydrolase / phosphoribosyl-AMP cyclohydrolase [EC:3.6.1.31 3.5.4.19] -0.100 1.127 0.930 0.976
hlpA, ompH; outer membrane protein -0.230 0.296 0.438 0.651
hlyIII; hemolysin III -0.202 0.335 0.547 0.680
holA; DNA polymerase III subunit delta [EC:2.7.7.7] -0.230 0.296 0.438 0.651
holB; DNA polymerase III subunit delta’ [EC:2.7.7.7] -0.230 0.296 0.438 0.651
hppA; K(+)-stimulated pyrophosphate-energized sodium pump [EC:3.6.1.1] -0.240 0.317 0.450 0.651
hprA; glycerate dehydrogenase [EC:1.1.1.29] -0.230 0.296 0.438 0.651
hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8] -0.230 0.296 0.438 0.651
hsdM; type I restriction enzyme M protein [EC:2.1.1.72] -0.227 0.303 0.455 0.651
hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3] -0.273 0.327 0.405 0.651
hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3] -0.246 0.299 0.411 0.651
hslR; ribosome-associated heat shock protein Hsp15 -0.230 0.296 0.438 0.651
HSP20; HSP20 family protein -0.254 0.323 0.433 0.651
HSP90A, htpG; molecular chaperone HtpG -0.230 0.296 0.438 0.651
htpX; heat shock protein HtpX [EC:3.4.24.-] -0.446 0.424 0.294 0.651
hupB; DNA-binding protein HU-beta -0.250 0.294 0.397 0.651
hutH, HAL; histidine ammonia-lyase [EC:4.3.1.3] -0.162 0.333 0.626 0.741
hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7] -0.162 0.333 0.626 0.741
hutU, UROC1; urocanate hydratase [EC:4.2.1.49] -0.162 0.333 0.626 0.741
hya; hyaluronoglucosaminidase [EC:3.2.1.35] -0.247 0.317 0.437 0.651
IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5] -0.220 0.308 0.477 0.651
icmF; isobutyryl-CoA mutase [EC:5.4.99.13] -0.228 0.317 0.474 0.651
IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42] -0.429 1.387 0.758 0.843
idnO; gluconate 5-dehydrogenase [EC:1.1.1.69] -0.542 0.584 0.355 0.651
ihfA, himA; integration host factor subunit alpha -0.364 0.544 0.505 0.651
ilvC; ketol-acid reductoisomerase [EC:1.1.1.86] -0.548 0.584 0.350 0.651
ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9] -0.548 0.584 0.350 0.651
IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205] -0.230 0.296 0.438 0.651
ina; immune inhibitor A [EC:3.4.24.-] -0.257 0.319 0.422 0.651
infA; translation initiation factor IF-1 -0.230 0.296 0.438 0.651
infB, MTIF2; translation initiation factor IF-2 -0.230 0.296 0.438 0.651
infC, MTIF3; translation initiation factor IF-3 -0.230 0.296 0.438 0.651
inlA; internalin A -0.221 0.572 0.699 0.797
INO1, ISYNA1; myo-inositol-1-phosphate synthase [EC:5.5.1.4] -0.144 0.334 0.667 0.778
INV, sacA; beta-fructofuranosidase [EC:3.2.1.26] -0.496 0.487 0.311 0.651
ispB; octaprenyl-diphosphate synthase [EC:2.5.1.90] -0.230 0.296 0.438 0.651
ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60] -0.232 0.307 0.452 0.651
ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148] -0.230 0.296 0.438 0.651
ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12] -0.230 0.296 0.438 0.651
ispH, lytB; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4] -0.230 0.296 0.438 0.651
K00243; uncharacterized protein -0.230 0.296 0.438 0.651
K01163; uncharacterized protein -0.113 0.281 0.688 0.797
K02477; two-component system, LytTR family, response regulator -0.221 0.571 0.700 0.797
K02481; two-component system, NtrC family, response regulator 2.304 1.989 0.248 0.651
K06871; uncharacterized protein -0.311 0.327 0.343 0.651
K06872; uncharacterized protein -0.253 0.518 0.626 0.741
K06885; uncharacterized protein -0.115 0.303 0.705 0.799
K06889; uncharacterized protein -0.239 0.319 0.455 0.651
K06890; uncharacterized protein -0.230 0.296 0.438 0.651
K06904; uncharacterized protein 0.358 0.550 0.516 0.651
K06915; uncharacterized protein -17.599 3454.822 0.996 0.998
K06921; uncharacterized protein -0.594 0.750 0.429 0.651
K06926; uncharacterized protein -0.511 0.365 0.164 0.651
K06950; uncharacterized protein -0.225 0.298 0.452 0.651
K06973; uncharacterized protein -0.754 1.120 0.502 0.651
K06975; uncharacterized protein -0.428 0.414 0.303 0.651
K07000; uncharacterized protein -0.219 0.301 0.469 0.651
K07001; NTE family protein -0.294 0.304 0.334 0.651
K07003; uncharacterized protein -0.248 0.345 0.474 0.651
K07005; uncharacterized protein -0.229 0.336 0.497 0.651
K07007; uncharacterized protein -0.226 0.306 0.462 0.651
K07011; uncharacterized protein -0.246 0.298 0.412 0.651
K07014; uncharacterized protein -0.335 0.976 0.732 0.826
K07025; putative hydrolase of the HAD superfamily -0.232 0.310 0.456 0.651
K07027; glycosyltransferase 2 family protein -0.230 0.296 0.438 0.651
K07037; uncharacterized protein -0.230 0.296 0.438 0.651
K07043; uncharacterized protein -0.754 1.120 0.502 0.651
K07052; uncharacterized protein -0.250 0.275 0.365 0.651
K07054; uncharacterized protein -0.049 0.358 0.891 0.966
K07058; membrane protein -0.229 0.309 0.461 0.651
K07078; uncharacterized protein -17.599 3454.822 0.996 0.998
K07082; UPF0755 protein -0.230 0.296 0.438 0.651
K07085; putative transport protein -0.247 0.292 0.398 0.651
K07088; uncharacterized protein -0.089 0.344 0.796 0.879
K07090; uncharacterized protein -0.307 0.429 0.475 0.651
K07095; uncharacterized protein -0.256 0.314 0.416 0.651
K07098; uncharacterized protein -0.230 0.306 0.452 0.651
K07126; uncharacterized protein -0.275 0.524 0.601 0.723
K07133; uncharacterized protein -0.250 0.312 0.424 0.651
K07137; uncharacterized protein -0.230 0.296 0.438 0.651
K07139; uncharacterized protein -0.228 0.293 0.436 0.651
K07150; uncharacterized protein -0.754 1.120 0.502 0.651
K07164; uncharacterized protein -0.230 0.296 0.438 0.651
K07166; ACT domain-containing protein 18.519 3411.091 0.996 0.998
K07220; uncharacterized protein 2.304 1.989 0.248 0.651
K07270; glycosyl transferase, family 25 0.358 0.550 0.516 0.651
K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72] 0.248 1.294 0.848 0.924
K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72] -0.297 0.684 0.664 0.776
K07387; putative metalloprotease [EC:3.4.24.-] -0.247 0.316 0.435 0.651
K07454; putative restriction endonuclease -0.001 1.049 0.999 0.999
K07481; transposase, IS5 family -0.256 0.444 0.566 0.693
K07483; transposase -0.398 0.499 0.426 0.651
K07484; transposase 18.519 3411.091 0.996 0.998
K07491; putative transposase 2.304 1.989 0.248 0.651
K07496; putative transposase 2.304 1.989 0.248 0.651
K07504; predicted type IV restriction endonuclease 0.054 0.493 0.913 0.976
K07727; putative transcriptional regulator -0.211 0.577 0.715 0.809
K07729; putative transcriptional regulator -0.054 0.371 0.885 0.961
K08303; putative protease [EC:3.4.-.-] -0.225 0.301 0.457 0.651
K08884; serine/threonine protein kinase, bacterial [EC:2.7.11.1] -0.098 0.320 0.761 0.844
K08961; chondroitin-sulfate-ABC endolyase/exolyase [EC:4.2.2.20 4.2.2.21] -0.677 0.652 0.301 0.651
K08987; putative membrane protein 0.038 0.353 0.913 0.976
K08998; uncharacterized protein -0.224 0.269 0.406 0.651
K08999; uncharacterized protein -0.216 0.297 0.468 0.651
K09117; uncharacterized protein -0.480 0.429 0.265 0.651
K09124; uncharacterized protein 0.092 1.404 0.948 0.986
K09125; uncharacterized protein -0.219 0.301 0.468 0.651
K09137; uncharacterized protein 0.358 0.550 0.516 0.651
K09155; uncharacterized protein -0.226 0.296 0.445 0.651
K09157; uncharacterized protein 18.519 3411.091 0.996 0.998
K09704; uncharacterized protein -0.223 0.285 0.435 0.651
K09797; uncharacterized protein -0.400 0.427 0.350 0.651
K09805; uncharacterized protein -0.659 0.562 0.243 0.651
K09861; uncharacterized protein -0.230 0.296 0.438 0.651
K09922; uncharacterized protein 18.519 3411.091 0.996 0.998
K09924; uncharacterized protein -0.280 0.500 0.577 0.703
K09955; uncharacterized protein -0.691 0.615 0.263 0.651
K09973; uncharacterized protein 0.151 1.352 0.911 0.976
K09975; uncharacterized protein -0.172 0.359 0.633 0.746
K13652; AraC family transcriptional regulator -2.232 1.933 0.250 0.651
K15977; putative oxidoreductase -0.050 0.281 0.859 0.934
KAE1, tsaD, QRI7; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234] -0.230 0.296 0.438 0.651
KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] -0.230 0.296 0.438 0.651
kbl, GCAT; glycine C-acetyltransferase [EC:2.3.1.29] -0.323 0.372 0.387 0.651
kch, trkA, mthK, pch; voltage-gated potassium channel 0.358 0.550 0.516 0.651
kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45] -0.577 0.590 0.329 0.651
kdpA; K+-transporting ATPase ATPase A chain [EC:3.6.3.12] 2.304 1.989 0.248 0.651
kdpB; K+-transporting ATPase ATPase B chain [EC:3.6.3.12] 2.304 1.989 0.248 0.651
kdpC; K+-transporting ATPase ATPase C chain [EC:3.6.3.12] 2.304 1.989 0.248 0.651
kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3] 2.304 1.989 0.248 0.651
kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55] -0.230 0.296 0.438 0.651
kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38] -0.243 0.292 0.407 0.651
kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45] -0.232 0.301 0.441 0.651
kdsD, kpsF; arabinose-5-phosphate isomerase [EC:5.3.1.13] -0.230 0.296 0.438 0.651
kdtA, waaA; 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.4.99.12 2.4.99.13 2.4.99.14 2.4.99.15] -0.230 0.296 0.438 0.651
kduI; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase [EC:5.3.1.17] -0.676 0.652 0.302 0.651
korA, oorA, oforA; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11] -0.241 0.306 0.433 0.651
korB, oorB, oforB; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11] -0.241 0.306 0.433 0.651
korC, oorC; 2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3] -0.230 0.296 0.438 0.651
korD, oorD; 2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3] -0.230 0.296 0.438 0.651
ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182] -0.230 0.296 0.438 0.651
kup; KUP system potassium uptake protein -0.098 0.312 0.753 0.841
lacA; galactoside O-acetyltransferase [EC:2.3.1.18] -0.062 0.367 0.865 0.940
lacI, galR; LacI family transcriptional regulator -0.239 0.298 0.424 0.651
lacZ; beta-galactosidase [EC:3.2.1.23] -0.222 0.291 0.446 0.651
LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4] -0.222 0.299 0.458 0.651
lctP; lactate permease -0.289 0.546 0.598 0.723
ldhA; D-lactate dehydrogenase [EC:1.1.1.28] -0.088 0.288 0.760 0.844
lemA; LemA protein -0.230 0.290 0.428 0.651
lepA; GTP-binding protein LepA -0.230 0.296 0.438 0.651
lepB; signal peptidase I [EC:3.4.21.89] -0.223 0.297 0.456 0.651
leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13] -0.100 1.127 0.930 0.976
leuB, IMDH; 3-isopropylmalate dehydrogenase [EC:1.1.1.85] -0.100 1.127 0.930 0.976
leuC, IPMI-L; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35] -0.100 1.127 0.930 0.976
leuD, IPMI-S; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35] -0.100 1.127 0.930 0.976
licD; lipopolysaccharide cholinephosphotransferase [EC:2.7.8.-] -0.176 0.308 0.568 0.695
lipA; lipoyl synthase [EC:2.8.1.8] -0.230 0.317 0.469 0.651
lldE; L-lactate dehydrogenase complex protein LldE -0.233 0.320 0.468 0.651
lldF; L-lactate dehydrogenase complex protein LldF -0.233 0.320 0.468 0.651
lldG; L-lactate dehydrogenase complex protein LldG -0.233 0.320 0.468 0.651
lolA; outer membrane lipoprotein carrier protein -0.750 0.852 0.380 0.651
lolC_E; lipoprotein-releasing system permease protein -0.230 0.296 0.438 0.651
lolD; lipoprotein-releasing system ATP-binding protein [EC:3.6.3.-] -0.230 0.296 0.438 0.651
lon; ATP-dependent Lon protease [EC:3.4.21.53] -0.220 0.308 0.477 0.651
lplA, lplJ; lipoate—protein ligase [EC:6.3.1.20] -0.717 0.722 0.322 0.651
lptB; lipopolysaccharide export system ATP-binding protein [EC:3.6.3.-] -0.230 0.296 0.438 0.651
lptF; lipopolysaccharide export system permease protein -0.230 0.296 0.438 0.651
lptG; lipopolysaccharide export system permease protein -0.230 0.296 0.438 0.651
lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129] -0.230 0.296 0.438 0.651
lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182] -0.230 0.296 0.438 0.651
lpxC-fabZ; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase / 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:3.5.1.108 4.2.1.59] -0.230 0.296 0.438 0.651
lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191] -0.230 0.296 0.438 0.651
lpxH; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54] -0.230 0.296 0.438 0.651
lpxK; tetraacyldisaccharide 4’-kinase [EC:2.7.1.130] -0.230 0.296 0.438 0.651
lpxL, htrB; Kdo2-lipid IVA lauroyltransferase [EC:2.3.1.241] -0.230 0.296 0.438 0.651
lrp; Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein -0.042 0.347 0.904 0.976
lspA; signal peptidase II [EC:3.4.23.36] -0.230 0.296 0.438 0.651
ltaE; threonine aldolase [EC:4.1.2.48] -0.170 0.761 0.824 0.900
ltrA; RNA-directed DNA polymerase [EC:2.7.7.49] 2.304 1.989 0.248 0.651
luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21] -0.263 0.312 0.401 0.651
LYS1; saccharopine dehydrogenase (NAD+, L-lysine forming) [EC:1.5.1.7] -0.230 0.296 0.438 0.651
lysA; diaminopimelate decarboxylase [EC:4.1.1.20] -0.274 0.307 0.374 0.651
lysC; aspartate kinase [EC:2.7.2.4] -0.230 0.296 0.438 0.651
maa; maltose O-acetyltransferase [EC:2.3.1.79] -0.230 0.328 0.484 0.651
maf; septum formation protein -0.230 0.296 0.438 0.651
mal; methylaspartate ammonia-lyase [EC:4.3.1.2] -0.221 0.572 0.699 0.797
malQ; 4-alpha-glucanotransferase [EC:2.4.1.25] -0.230 0.296 0.438 0.651
malY, malT; maltose/moltooligosaccharide transporter -0.228 0.293 0.436 0.651
malZ; alpha-glucosidase [EC:3.2.1.20] -0.117 0.305 0.702 0.797
MAN; mannan endo-1,4-beta-mannosidase [EC:3.2.1.78] -0.189 0.299 0.528 0.663
manA, MPI; mannose-6-phosphate isomerase [EC:5.3.1.8] -0.230 0.296 0.438 0.651
manB; phosphomannomutase [EC:5.4.2.8] -0.230 0.296 0.438 0.651
manC, cpsB; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13] -0.230 0.296 0.438 0.651
map; methionyl aminopeptidase [EC:3.4.11.18] -0.224 0.289 0.440 0.651
marC; multiple antibiotic resistance protein -0.754 1.120 0.502 0.651
MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10] -0.230 0.296 0.438 0.651
mbtN, fadE14; acyl-ACP dehydrogenase [EC:1.3.99.-] -0.754 1.120 0.502 0.651
mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-] 0.358 0.550 0.516 0.651
mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC 0.358 0.550 0.516 0.651
mdh; malate dehydrogenase [EC:1.1.1.37] -0.230 0.296 0.438 0.651
menA; 1,4-dihydroxy-2-naphthoate octaprenyltransferase [EC:2.5.1.74 2.5.1.-] -0.230 0.296 0.438 0.651
menB; naphthoate synthase [EC:4.1.3.36] -0.230 0.296 0.438 0.651
menD; 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [EC:2.2.1.9] -0.230 0.296 0.438 0.651
menE; O-succinylbenzoic acid—CoA ligase [EC:6.2.1.26] -0.219 0.301 0.468 0.651
mepS, spr; murein DD-endopeptidase / murein LD-carboxypeptidase [EC:3.4.-.- 3.4.17.13] -0.754 1.120 0.502 0.651
metA; homoserine O-succinyltransferase/O-acetyltransferase [EC:2.3.1.46 2.3.1.31] -0.274 0.307 0.374 0.651
metF, MTHFR; methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20] -0.264 0.307 0.391 0.651
metH, MTR; 5-methyltetrahydrofolate–homocysteine methyltransferase [EC:2.1.1.13] -0.206 0.312 0.510 0.651
metK; S-adenosylmethionine synthetase [EC:2.5.1.6] -0.243 0.292 0.407 0.651
metY; O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49] -0.208 0.306 0.498 0.651
mfd; transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-] -0.230 0.296 0.438 0.651
mgp; 4-O-beta-D-mannosyl-D-glucose phosphorylase [EC:2.4.1.281] -0.588 0.587 0.318 0.651
mgtC; putative Mg2+ transporter-C (MgtC) family protein -0.280 0.308 0.365 0.651
miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75] -0.230 0.296 0.438 0.651
miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3] -0.230 0.296 0.438 0.651
mlaD, linM; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein -0.230 0.296 0.438 0.651
mlaE, linK; phospholipid/cholesterol/gamma-HCH transport system permease protein -0.230 0.296 0.438 0.651
mlaF, linL, mkl; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein -0.230 0.296 0.438 0.651
mltD, dniR; membrane-bound lytic murein transglycosylase D [EC:4.2.2.-] -0.235 0.297 0.430 0.651
mltF; membrane-bound lytic murein transglycosylase F [EC:4.2.2.-] -0.468 0.400 0.244 0.651
MMAB, pduO; cob(I)alamin adenosyltransferase [EC:2.5.1.17] -0.263 0.312 0.401 0.651
mnmA, trmU; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13] -0.230 0.296 0.438 0.651
mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-] -0.230 0.296 0.438 0.651
mntH; manganese transport protein -0.224 0.319 0.483 0.651
moaA, CNX2; GTP 3’,8-cyclase [EC:4.1.99.22] -0.137 0.613 0.823 0.900
mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72] -0.171 0.451 0.705 0.799
modF; molybdate transport system ATP-binding protein 18.519 3411.091 0.996 0.998
motB; chemotaxis protein MotB -0.230 0.296 0.438 0.651
moxR; MoxR-like ATPase [EC:3.6.3.-] -0.170 0.284 0.551 0.683
mp2; beta-1,4-mannooligosaccharide/beta-1,4-mannosyl-N-acetylglucosamine phosphorylase [EC:2.4.1.319 2.4.1.320] -0.234 0.288 0.419 0.651
mraW, rsmH; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199] -0.230 0.296 0.438 0.651
mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] -0.230 0.296 0.438 0.651
mraZ; MraZ protein -0.262 0.309 0.398 0.651
mrcA; penicillin-binding protein 1A [EC:2.4.1.129 3.4.16.4] -0.230 0.296 0.438 0.651
mrdA; penicillin-binding protein 2 [EC:3.4.16.4] -0.194 0.303 0.523 0.657
mreB; rod shape-determining protein MreB and related proteins -0.230 0.296 0.438 0.651
mreC; rod shape-determining protein MreC -0.230 0.296 0.438 0.651
mrp, NUBPL; ATP-binding protein involved in chromosome partitioning -0.230 0.296 0.438 0.651
mrr; restriction system protein -0.301 0.567 0.596 0.722
msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:3.6.3.-] -0.230 0.296 0.438 0.651
mscL; large conductance mechanosensitive channel -0.230 0.296 0.438 0.651
mscS; small conductance mechanosensitive channel -0.754 1.120 0.502 0.651
msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12] -0.230 0.296 0.438 0.651
mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5] -0.230 0.296 0.438 0.651
MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9] -0.230 0.296 0.438 0.651
mtgA; monofunctional glycosyltransferase [EC:2.4.1.129] -0.230 0.296 0.438 0.651
MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2] -0.230 0.296 0.438 0.651
mtnN, mtn, pfs; adenosylhomocysteine nucleosidase [EC:3.2.2.9] -0.230 0.296 0.438 0.651
MuB; ATP-dependent target DNA activator [EC:3.6.1.3] -0.261 0.938 0.781 0.865
murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] -0.230 0.296 0.438 0.651
murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] -0.230 0.296 0.438 0.651
murC; UDP-N-acetylmuramate–alanine ligase [EC:6.3.2.8] -0.230 0.296 0.438 0.651
murD; UDP-N-acetylmuramoylalanine–D-glutamate ligase [EC:6.3.2.9] -0.230 0.296 0.438 0.651
murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase [EC:6.3.2.13] -0.230 0.296 0.438 0.651
murF; UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase [EC:6.3.2.10] -0.230 0.296 0.438 0.651
murG; UDP-N-acetylglucosamine–N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] -0.230 0.296 0.438 0.651
murI; glutamate racemase [EC:5.1.1.3] -0.230 0.296 0.438 0.651
murQ; N-acetylmuramic acid 6-phosphate etherase [EC:4.2.1.126] -0.747 0.519 0.152 0.651
mutL; DNA mismatch repair protein MutL -0.230 0.296 0.438 0.651
mutS; DNA mismatch repair protein MutS -0.230 0.296 0.438 0.651
mutS2; DNA mismatch repair protein MutS2 -0.230 0.296 0.438 0.651
mutT, NUDT15, MTH2; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] -0.128 0.324 0.693 0.797
mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] -0.230 0.296 0.438 0.651
mviM; virulence factor -0.262 0.328 0.427 0.651
mvpA, vapC; tRNA(fMet)-specific endonuclease VapC [EC:3.1.-.-] 0.141 0.367 0.701 0.797
nadA; quinolinate synthase [EC:2.5.1.72] -0.172 0.328 0.602 0.723
nadB; L-aspartate oxidase [EC:1.4.3.16] -0.172 0.328 0.602 0.723
nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19] -0.172 0.328 0.602 0.723
nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18] -0.230 0.296 0.438 0.651
nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6] -0.226 0.290 0.438 0.651
NAGLU; alpha-N-acetylglucosaminidase [EC:3.2.1.50] -0.855 0.801 0.287 0.651
NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22] -0.230 0.296 0.438 0.651
ndh; NADH dehydrogenase [EC:1.6.99.3] -0.211 0.290 0.469 0.651
ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6] -0.754 1.120 0.502 0.651
NEU1; sialidase-1 [EC:3.2.1.18] -0.234 0.288 0.419 0.651
neuA; N-acylneuraminate cytidylyltransferase [EC:2.7.7.43] -2.232 1.933 0.250 0.651
nfrA2; FMN reductase [NAD(P)H] [EC:1.5.1.39] -0.230 0.296 0.438 0.651
nhaA; Na+:H+ antiporter, NhaA family -0.205 0.309 0.509 0.651
nhaC; Na+:H+ antiporter, NhaC family 18.519 3411.091 0.996 0.998
norB, norC; MFS transporter, DHA2 family, multidrug resistance protein 2.304 1.989 0.248 0.651
norB; nitric oxide reductase subunit B [EC:1.7.2.5] 0.054 0.493 0.913 0.976
nosD; nitrous oxidase accessory protein -0.319 0.983 0.746 0.834
nosF; Cu-processing system ATP-binding protein -0.319 0.983 0.746 0.834
nosL; copper chaperone NosL -0.319 0.983 0.746 0.834
nosY; Cu-processing system permease protein -0.319 0.983 0.746 0.834
nosZ; nitrous-oxide reductase [EC:1.7.2.4] -0.319 0.983 0.746 0.834
npdA; NAD-dependent deacetylase [EC:3.5.1.-] -0.263 0.312 0.401 0.651
nqrA; Na+-transporting NADH:ubiquinone oxidoreductase subunit A [EC:1.6.5.8] -0.230 0.296 0.438 0.651
nqrB; Na+-transporting NADH:ubiquinone oxidoreductase subunit B [EC:1.6.5.8] -0.230 0.296 0.438 0.651
nqrC; Na+-transporting NADH:ubiquinone oxidoreductase subunit C [EC:1.6.5.8] -0.230 0.296 0.438 0.651
nqrD; Na+-transporting NADH:ubiquinone oxidoreductase subunit D [EC:1.6.5.8] -0.230 0.296 0.438 0.651
nqrE; Na+-transporting NADH:ubiquinone oxidoreductase subunit E [EC:1.6.5.8] -0.230 0.296 0.438 0.651
nqrF; Na+-transporting NADH:ubiquinone oxidoreductase subunit F [EC:1.6.5.8] -0.230 0.296 0.438 0.651
nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4] -0.230 0.296 0.438 0.651
nrfA; nitrite reductase (cytochrome c-552) [EC:1.7.2.2] -0.217 0.299 0.469 0.651
nrfH; cytochrome c nitrite reductase small subunit -0.217 0.299 0.469 0.651
nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3] -0.230 0.296 0.438 0.651
nspC; carboxynorspermidine decarboxylase [EC:4.1.1.96] -0.230 0.296 0.438 0.651
NTH; endonuclease III [EC:4.2.99.18] -0.230 0.296 0.438 0.651
nuoA; NADH-quinone oxidoreductase subunit A [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoB; NADH-quinone oxidoreductase subunit B [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoCD; NADH-quinone oxidoreductase subunit C/D [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoH; NADH-quinone oxidoreductase subunit H [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoI; NADH-quinone oxidoreductase subunit I [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoJ; NADH-quinone oxidoreductase subunit J [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoK; NADH-quinone oxidoreductase subunit K [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoL; NADH-quinone oxidoreductase subunit L [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoM; NADH-quinone oxidoreductase subunit M [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nuoN; NADH-quinone oxidoreductase subunit N [EC:1.6.5.3] -0.230 0.296 0.438 0.651
nupG; MFS transporter, NHS family, nucleoside permease -0.230 0.296 0.438 0.651
nusA; N utilization substance protein A -0.230 0.296 0.438 0.651
nusB; N utilization substance protein B -0.230 0.296 0.438 0.651
nusG; transcriptional antiterminator NusG -0.230 0.296 0.438 0.651
obgE, cgtA; GTPase [EC:3.6.5.-] -0.230 0.296 0.438 0.651
ogt, MGMT; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63] -0.155 0.301 0.607 0.723
ompX; outer membrane protein X -0.096 0.328 0.770 0.853
oprO_P; phosphate-selective porin OprO and OprP -0.180 0.298 0.546 0.680
oxyR; LysR family transcriptional regulator, hydrogen peroxide-inducible genes activator -0.213 0.298 0.476 0.651
pabB; para-aminobenzoate synthetase component I [EC:2.6.1.85] -0.158 0.328 0.632 0.746
pabC; 4-amino-4-deoxychorismate lyase [EC:4.1.3.38] -0.158 0.328 0.632 0.746
padR; PadR family transcriptional regulator, regulatory protein PadR -1.243 1.127 0.272 0.651
panB; 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11] -0.213 0.298 0.477 0.651
panC; pantoate–beta-alanine ligase [EC:6.3.2.1] -0.213 0.298 0.477 0.651
panD; aspartate 1-decarboxylase [EC:4.1.1.11] -0.213 0.298 0.477 0.651
panE, apbA; 2-dehydropantoate 2-reductase [EC:1.1.1.169] -0.220 0.329 0.504 0.651
parA, soj; chromosome partitioning protein -0.290 0.310 0.351 0.651
parB, spo0J; chromosome partitioning protein, ParB family -0.230 0.296 0.438 0.651
parC; topoisomerase IV subunit A [EC:5.99.1.-] -0.230 0.296 0.438 0.651
parE; topoisomerase IV subunit B [EC:5.99.1.-] -0.230 0.296 0.438 0.651
PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15] -0.230 0.296 0.438 0.651
patB, malY; cystathione beta-lyase [EC:4.4.1.8] -0.267 0.319 0.403 0.651
pbuG; putative MFS transporter, AGZA family, xanthine/uracil permease -0.219 0.301 0.468 0.651
pcaC; 4-carboxymuconolactone decarboxylase [EC:4.1.1.44] -0.135 0.612 0.825 0.900
pcnB; poly(A) polymerase [EC:2.7.7.19] -0.754 1.120 0.502 0.651
PCYT1; choline-phosphate cytidylyltransferase [EC:2.7.7.15] -0.221 0.572 0.699 0.797
PDF, def; peptide deformylase [EC:3.5.1.88] -0.230 0.296 0.438 0.651
pdxA; 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262] -0.230 0.296 0.438 0.651
pdxB; erythronate-4-phosphate dehydrogenase [EC:1.1.1.290] -0.754 1.120 0.502 0.651
pdxJ; pyridoxine 5-phosphate synthase [EC:2.6.99.2] -0.754 1.120 0.502 0.651
pdxK, pdxY; pyridoxine kinase [EC:2.7.1.35] -0.186 0.306 0.545 0.680
pdxS, pdx1; pyridoxal 5’-phosphate synthase pdxS subunit [EC:4.3.3.6] -0.219 0.301 0.468 0.651
pdxT, pdx2; 5’-phosphate synthase pdxT subunit [EC:4.3.3.6] -0.219 0.301 0.468 0.651
penP; beta-lactamase class A [EC:3.5.2.6] -0.298 0.574 0.604 0.723
pepD; dipeptidase D [EC:3.4.13.-] -0.230 0.296 0.438 0.651
pepE; dipeptidase E [EC:3.4.13.21] -0.619 0.514 0.230 0.651
pepO; putative endopeptidase [EC:3.4.24.-] -0.192 0.304 0.529 0.663
pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9] -0.233 0.297 0.434 0.651
pepT; tripeptide aminopeptidase [EC:3.4.11.4] -0.230 0.296 0.438 0.651
perR; Fur family transcriptional regulator, peroxide stress response regulator -0.190 0.321 0.555 0.683
pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11] -0.230 0.296 0.438 0.651
pflA, pflC, pflE; pyruvate formate lyase activating enzyme [EC:1.97.1.4] -0.188 0.302 0.535 0.670
pfp, PFP; diphosphate-dependent phosphofructokinase [EC:2.7.1.90] -0.230 0.296 0.438 0.651
PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] 0.038 0.480 0.937 0.977
PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3] -0.230 0.296 0.438 0.651
pgm; phosphoglucomutase [EC:5.4.2.2] -0.230 0.296 0.438 0.651
pgpA; phosphatidylglycerophosphatase A [EC:3.1.3.27] -0.015 0.569 0.979 0.998
pgsA, PGS1; CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5] -0.227 0.517 0.662 0.775
pheA2; prephenate dehydratase [EC:4.2.1.51] -0.644 0.452 0.157 0.651
phnP; phosphoribosyl 1,2-cyclic phosphate phosphodiesterase [EC:3.1.4.55] -0.230 0.296 0.438 0.651
phoH, phoL; phosphate starvation-inducible protein PhoH and related proteins -0.230 0.296 0.438 0.651
phoN; acid phosphatase (class A) [EC:3.1.3.2] -0.073 0.305 0.811 0.894
phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3] -0.230 0.296 0.438 0.651
pip; proline iminopeptidase [EC:3.4.11.5] 18.519 3411.091 0.996 0.998
PK, pyk; pyruvate kinase [EC:2.7.1.40] -0.230 0.296 0.438 0.651
plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] -0.230 0.296 0.438 0.651
pnbA; para-nitrobenzyl esterase [EC:3.1.1.-] -0.508 0.875 0.562 0.689
PNC1; nicotinamidase [EC:3.5.1.19] 0.358 0.550 0.516 0.651
pncA; nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-] -0.097 0.315 0.757 0.843
pncB, NAPRT1; nicotinate phosphoribosyltransferase [EC:6.3.4.21] -0.231 0.296 0.438 0.651
pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42] -0.230 0.296 0.438 0.651
pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] -0.230 0.296 0.438 0.651
pnuC; nicotinamide mononucleotide transporter -0.230 0.296 0.438 0.651
polA; DNA polymerase I [EC:2.7.7.7] -0.230 0.296 0.438 0.651
por, nifJ; pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-] -0.230 0.296 0.438 0.651
ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1] -0.230 0.296 0.438 0.651
PPIB, ppiB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8] -0.146 0.307 0.634 0.747
ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8] -0.230 0.296 0.438 0.651
ppnK, NADK; NAD+ kinase [EC:2.7.1.23] -0.230 0.296 0.438 0.651
ppnN; pyrimidine/purine-5’-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-] -0.274 0.310 0.377 0.651
PPOX, hemY; protoporphyrinogen/coproporphyrinogen III oxidase [EC:1.3.3.4 1.3.3.15] -0.232 0.293 0.430 0.651
pqqL; zinc protease [EC:3.4.24.-] -0.201 0.306 0.512 0.651
PRDX2_4, ahpC; peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC:1.11.1.15] -0.231 0.296 0.438 0.651
PREP; prolyl oligopeptidase [EC:3.4.21.26] -0.210 0.327 0.521 0.656
prfA, MTRF1, MRF1; peptide chain release factor 1 -0.230 0.296 0.438 0.651
prfB; peptide chain release factor 2 -0.230 0.296 0.438 0.651
prfC; peptide chain release factor 3 -0.230 0.296 0.438 0.651
priA; primosomal protein N’ (replication factor Y) (superfamily II helicase) [EC:3.6.4.-] -0.230 0.296 0.438 0.651
prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-] -0.230 0.296 0.438 0.651
proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41] 18.519 3411.091 0.996 0.998
proB; glutamate 5-kinase [EC:2.7.2.11] 18.519 3411.091 0.996 0.998
proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2] 0.139 1.250 0.912 0.976
PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] -0.230 0.296 0.438 0.651
psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65] -0.230 0.296 0.438 0.651
pspC; phage shock protein C -0.429 0.536 0.424 0.651
pstS; phosphate transport system substrate-binding protein -0.230 0.296 0.438 0.651
ptb; phosphate butyryltransferase [EC:2.3.1.19] -0.147 0.329 0.655 0.768
PTH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29] -0.230 0.296 0.438 0.651
PTS-Gat-EIIC, gatC, sgcC; PTS system, galactitol-specific IIC component -0.676 0.652 0.302 0.651
pulA; pullulanase [EC:3.2.1.41] -0.252 0.318 0.429 0.651
punA, PNP; purine-nucleoside phosphorylase [EC:2.4.2.1] -0.230 0.296 0.438 0.651
purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4] -0.230 0.296 0.438 0.651
purB, ADSL; adenylosuccinate lyase [EC:4.3.2.2] -0.230 0.296 0.438 0.651
purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6] -0.230 0.296 0.438 0.651
purD; phosphoribosylamine—glycine ligase [EC:6.3.4.13] -0.230 0.296 0.438 0.651
purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18] -0.230 0.296 0.438 0.651
purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14] -0.219 0.308 0.477 0.651
purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] -0.230 0.296 0.438 0.651
purL, PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3] -0.220 0.308 0.477 0.651
purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1] -0.230 0.296 0.438 0.651
purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] -0.360 0.503 0.475 0.651
purT; phosphoribosylglycinamide formyltransferase 2 [EC:2.1.2.2] -0.193 0.294 0.513 0.651
purU; formyltetrahydrofolate deformylase [EC:3.5.1.10] -0.789 0.881 0.372 0.651
pycB; pyruvate carboxylase subunit B [EC:6.4.1.1] -0.230 0.296 0.438 0.651
PYG, glgP; glycogen phosphorylase [EC:2.4.1.1] -0.230 0.296 0.438 0.651
pyrB, PYR2; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2] -0.230 0.296 0.438 0.651
pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14] -0.230 0.296 0.438 0.651
pyrDII; dihydroorotate dehydrogenase electron transfer subunit -0.230 0.296 0.438 0.651
pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10] -0.230 0.296 0.438 0.651
pyrF; orotidine-5’-phosphate decarboxylase [EC:4.1.1.23] -0.230 0.296 0.438 0.651
pyrG, CTPS; CTP synthase [EC:6.3.4.2] -0.230 0.296 0.438 0.651
pyrH; uridylate kinase [EC:2.7.4.22] -0.230 0.296 0.438 0.651
pyrI; aspartate carbamoyltransferase regulatory subunit -0.230 0.296 0.438 0.651
pyrP, uraA; uracil permease -0.217 0.297 0.467 0.651
QARS, glnS; glutaminyl-tRNA synthetase [EC:6.1.1.18] -0.230 0.296 0.438 0.651
queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17] -0.225 0.301 0.457 0.651
queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20] -0.230 0.296 0.438 0.651
queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50] -0.395 0.451 0.383 0.651
queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13] -0.230 0.296 0.438 0.651
queG; epoxyqueuosine reductase [EC:1.17.99.6] -0.230 0.296 0.438 0.651
radA, sms; DNA repair protein RadA/Sms -0.284 0.308 0.358 0.651
radC; DNA repair protein RadC -0.230 0.296 0.438 0.651
ramA; alpha-L-rhamnosidase [EC:3.2.1.40] -0.319 0.983 0.746 0.834
RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19] -0.230 0.296 0.438 0.651
raxB, cvaB; ATP-binding cassette, subfamily B, bacterial RaxB 2.304 1.989 0.248 0.651
rbfA; ribosome-binding factor A -0.230 0.296 0.438 0.651
rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66] -0.230 0.296 0.438 0.651
recA; recombination protein RecA -0.230 0.296 0.438 0.651
recF; DNA replication and repair protein RecF -0.230 0.296 0.438 0.651
recG; ATP-dependent DNA helicase RecG [EC:3.6.4.12] -0.213 0.312 0.495 0.651
recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] -0.230 0.296 0.438 0.651
recN; DNA repair protein RecN (Recombination protein N) -0.230 0.296 0.438 0.651
recO; DNA repair protein RecO (recombination protein O) -0.230 0.296 0.438 0.651
recQ; ATP-dependent DNA helicase RecQ [EC:3.6.4.12] -0.243 0.293 0.409 0.651
recR; recombination protein RecR -0.230 0.296 0.438 0.651
recX; regulatory protein -0.230 0.296 0.438 0.651
relA; GTP pyrophosphokinase [EC:2.7.6.5] -0.231 0.299 0.439 0.651
RENBP; N-acylglucosamine 2-epimerase [EC:5.1.3.8] -0.240 0.289 0.409 0.651
res; type III restriction enzyme [EC:3.1.21.5] -5.080 10.936 0.643 0.756
RETSAT; all-trans-retinol 13,14-reductase [EC:1.3.99.23] -0.696 0.523 0.185 0.651
rfbC, rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] -0.230 0.296 0.438 0.651
rfbD, rmlD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] -0.230 0.296 0.438 0.651
rgpA_B; gingipain R [EC:3.4.22.37] -0.001 1.049 0.999 0.999
rgpB; rhamnosyltransferase [EC:2.4.1.-] 0.358 0.550 0.516 0.651
rhaA; L-rhamnose isomerase [EC:5.3.1.14] -0.810 0.830 0.330 0.651
rhaB; rhamnulokinase [EC:2.7.1.5] -0.810 0.830 0.330 0.651
rhaD; rhamnulose-1-phosphate aldolase [EC:4.1.2.19] -0.810 0.830 0.330 0.651
rhaM; L-rhamnose mutarotase [EC:5.1.3.32] -0.846 0.965 0.382 0.651
rhaT; L-rhamnose-H+ transport protein -0.789 0.881 0.372 0.651
rho; transcription termination factor Rho -0.230 0.296 0.438 0.651
ribB, RIB3; 3,4-dihydroxy 2-butanone 4-phosphate synthase [EC:4.1.99.12] 2.304 1.989 0.248 0.651
ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25] -0.231 0.296 0.437 0.651
ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193] -0.230 0.296 0.438 0.651
ribE, RIB5; riboflavin synthase [EC:2.5.1.9] -0.230 0.296 0.438 0.651
ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2] -0.230 0.296 0.438 0.651
ribH, RIB4; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78] -0.230 0.296 0.438 0.651
ridA, tdcF, RIDA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10] -0.230 0.296 0.438 0.651
rimM; 16S rRNA processing protein RimM -0.230 0.296 0.438 0.651
rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4] -0.230 0.296 0.438 0.651
rimP; ribosome maturation factor RimP -0.230 0.296 0.438 0.651
rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177] -0.230 0.296 0.438 0.651
rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191] -0.230 0.296 0.438 0.651
rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192] -0.230 0.296 0.438 0.651
rlpA; rare lipoprotein A -0.217 0.299 0.469 0.651
rluA; tRNA pseudouridine32 synthase / 23S rRNA pseudouridine746 synthase [EC:5.4.99.28 5.4.99.29] -0.223 0.336 0.508 0.651
rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22] -0.230 0.296 0.438 0.651
rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] -0.230 0.296 0.438 0.651
rmuC; DNA recombination protein RmuC -0.230 0.296 0.438 0.651
rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3] -0.217 0.299 0.469 0.651
rnfA; electron transport complex protein RnfA 18.519 3411.091 0.996 0.998
rnfC; electron transport complex protein RnfC 18.519 3411.091 0.996 0.998
rnfD; electron transport complex protein RnfD 18.519 3411.091 0.996 0.998
rnfE; electron transport complex protein RnfE 18.519 3411.091 0.996 0.998
rnfG; electron transport complex protein RnfG -0.222 0.324 0.494 0.651
rng, cafA; ribonuclease G [EC:3.1.26.-] -0.230 0.296 0.438 0.651
rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4] -0.230 0.296 0.438 0.651
rnhB; ribonuclease HII [EC:3.1.26.4] -0.230 0.296 0.438 0.651
rnj; ribonuclease J [EC:3.1.-.-] -0.319 0.983 0.746 0.834
rnpA; ribonuclease P protein component [EC:3.1.26.5] -0.230 0.296 0.438 0.651
rnr, vacB; ribonuclease R [EC:3.1.-.-] -0.230 0.296 0.438 0.651
rny; ribonucrease Y [EC:3.1.-.-] -0.230 0.296 0.438 0.651
rnz; ribonuclease Z [EC:3.1.26.11] -0.230 0.296 0.438 0.651
rodA, mrdB; rod shape determining protein RodA -0.230 0.296 0.438 0.651
RP-L1, MRPL1, rplA; large subunit ribosomal protein L1 -0.230 0.296 0.438 0.651
RP-L10, MRPL10, rplJ; large subunit ribosomal protein L10 -0.230 0.296 0.438 0.651
RP-L11, MRPL11, rplK; large subunit ribosomal protein L11 -0.230 0.296 0.438 0.651
RP-L13, MRPL13, rplM; large subunit ribosomal protein L13 -0.230 0.296 0.438 0.651
RP-L14, MRPL14, rplN; large subunit ribosomal protein L14 -0.230 0.296 0.438 0.651
RP-L15, MRPL15, rplO; large subunit ribosomal protein L15 -0.230 0.296 0.438 0.651
RP-L16, MRPL16, rplP; large subunit ribosomal protein L16 -0.230 0.296 0.438 0.651
RP-L17, MRPL17, rplQ; large subunit ribosomal protein L17 -0.201 0.284 0.481 0.651
RP-L18, MRPL18, rplR; large subunit ribosomal protein L18 -0.230 0.296 0.438 0.651
RP-L19, MRPL19, rplS; large subunit ribosomal protein L19 -0.230 0.296 0.438 0.651
RP-L2, MRPL2, rplB; large subunit ribosomal protein L2 -0.230 0.296 0.438 0.651
RP-L20, MRPL20, rplT; large subunit ribosomal protein L20 -0.230 0.296 0.438 0.651
RP-L21, MRPL21, rplU; large subunit ribosomal protein L21 -0.230 0.296 0.438 0.651
RP-L22, MRPL22, rplV; large subunit ribosomal protein L22 -0.230 0.296 0.438 0.651
RP-L23, MRPL23, rplW; large subunit ribosomal protein L23 -0.230 0.296 0.438 0.651
RP-L24, MRPL24, rplX; large subunit ribosomal protein L24 -0.230 0.296 0.438 0.651
RP-L25, rplY; large subunit ribosomal protein L25 -0.230 0.296 0.438 0.651
RP-L27, MRPL27, rpmA; large subunit ribosomal protein L27 -0.230 0.296 0.438 0.651
RP-L28, MRPL28, rpmB; large subunit ribosomal protein L28 -0.230 0.296 0.438 0.651
RP-L29, rpmC; large subunit ribosomal protein L29 -0.230 0.296 0.438 0.651
RP-L3, MRPL3, rplC; large subunit ribosomal protein L3 -0.230 0.296 0.438 0.651
RP-L30, MRPL30, rpmD; large subunit ribosomal protein L30 -0.230 0.296 0.438 0.651
RP-L31, rpmE; large subunit ribosomal protein L31 -0.230 0.296 0.438 0.651
RP-L32, MRPL32, rpmF; large subunit ribosomal protein L32 -0.230 0.296 0.438 0.651
RP-L33, MRPL33, rpmG; large subunit ribosomal protein L33 -0.230 0.296 0.438 0.651
RP-L34, MRPL34, rpmH; large subunit ribosomal protein L34 -0.228 0.293 0.436 0.651
RP-L35, MRPL35, rpmI; large subunit ribosomal protein L35 -0.230 0.296 0.438 0.651
RP-L36, MRPL36, rpmJ; large subunit ribosomal protein L36 -0.123 0.303 0.685 0.796
RP-L4, MRPL4, rplD; large subunit ribosomal protein L4 -0.230 0.296 0.438 0.651
RP-L5, MRPL5, rplE; large subunit ribosomal protein L5 -0.230 0.296 0.438 0.651
RP-L6, MRPL6, rplF; large subunit ribosomal protein L6 -0.230 0.296 0.438 0.651
RP-L7, MRPL12, rplL; large subunit ribosomal protein L7/L12 -0.230 0.296 0.438 0.651
RP-L9, MRPL9, rplI; large subunit ribosomal protein L9 -0.230 0.296 0.438 0.651
RP-S1, rpsA; small subunit ribosomal protein S1 -0.230 0.296 0.438 0.651
RP-S10, MRPS10, rpsJ; small subunit ribosomal protein S10 -0.230 0.296 0.438 0.651
RP-S11, MRPS11, rpsK; small subunit ribosomal protein S11 -0.230 0.296 0.438 0.651
RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12 -0.230 0.296 0.438 0.651
RP-S13, rpsM; small subunit ribosomal protein S13 -0.230 0.296 0.438 0.651
RP-S14, MRPS14, rpsN; small subunit ribosomal protein S14 -0.230 0.296 0.438 0.651
RP-S15, MRPS15, rpsO; small subunit ribosomal protein S15 -0.230 0.296 0.438 0.651
RP-S16, MRPS16, rpsP; small subunit ribosomal protein S16 -0.230 0.296 0.438 0.651
RP-S17, MRPS17, rpsQ; small subunit ribosomal protein S17 -0.230 0.296 0.438 0.651
RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18 -0.230 0.296 0.438 0.651
RP-S19, rpsS; small subunit ribosomal protein S19 -0.230 0.296 0.438 0.651
RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2 -0.230 0.296 0.438 0.651
RP-S20, rpsT; small subunit ribosomal protein S20 -0.230 0.296 0.438 0.651
RP-S21, MRPS21, rpsU; small subunit ribosomal protein S21 -0.230 0.296 0.438 0.651
RP-S3, rpsC; small subunit ribosomal protein S3 -0.230 0.296 0.438 0.651
RP-S4, rpsD; small subunit ribosomal protein S4 -0.230 0.296 0.438 0.651
RP-S5, MRPS5, rpsE; small subunit ribosomal protein S5 -0.230 0.296 0.438 0.651
RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6 -0.230 0.296 0.438 0.651
RP-S7, MRPS7, rpsG; small subunit ribosomal protein S7 -0.230 0.296 0.438 0.651
RP-S8, rpsH; small subunit ribosomal protein S8 -0.230 0.296 0.438 0.651
RP-S9, MRPS9, rpsI; small subunit ribosomal protein S9 -0.230 0.296 0.438 0.651
rpe, RPE; ribulose-phosphate 3-epimerase [EC:5.1.3.1] -0.230 0.296 0.438 0.651
rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6] -0.230 0.296 0.438 0.651
rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] -0.220 0.308 0.477 0.651
rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] -0.230 0.296 0.438 0.651
rpoC; DNA-directed RNA polymerase subunit beta’ [EC:2.7.7.6] -0.230 0.296 0.438 0.651
rpoD; RNA polymerase primary sigma factor -0.226 0.304 0.458 0.651
rpoE; RNA polymerase sigma-70 factor, ECF subfamily -0.274 0.308 0.375 0.651
rpoN; RNA polymerase sigma-54 factor -0.230 0.296 0.438 0.651
rseC; sigma-E factor negative regulatory protein RseC 18.519 3411.091 0.996 0.998
rseP; regulator of sigma E protease [EC:3.4.24.-] -0.230 0.296 0.438 0.651
rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] -0.230 0.296 0.438 0.651
rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193] -0.230 0.296 0.438 0.651
rsmI; 16S rRNA (cytidine1402-2’-O)-methyltransferase [EC:2.1.1.198] -0.242 0.294 0.412 0.651
RTCB, rtcB; tRNA-splicing ligase RtcB (3’-phosphate/5’-hydroxy nucleic acid ligase) [EC:6.5.1.8] -2.232 1.933 0.250 0.651
rtpR; ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2] -0.230 0.296 0.438 0.651
rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190] -0.230 0.296 0.438 0.651
ruvA; holliday junction DNA helicase RuvA [EC:3.6.4.12] -0.230 0.296 0.438 0.651
ruvB; holliday junction DNA helicase RuvB [EC:3.6.4.12] -0.230 0.296 0.438 0.651
ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4] -0.230 0.296 0.438 0.651
ruvX; putative holliday junction resolvase [EC:3.1.-.-] -0.230 0.296 0.438 0.651
sacC, levB; levanase [EC:3.2.1.65] -0.223 0.321 0.489 0.651
SAM50, TOB55, bamA; outer membrane protein insertion porin family -0.230 0.296 0.438 0.651
sanA; SanA protein -0.089 0.344 0.796 0.879
SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11] -0.230 0.296 0.438 0.651
sbcD, mre11; DNA repair protein SbcD/Mre11 -0.746 1.115 0.505 0.651
sdhA, frdA; succinate dehydrogenase / fumarate reductase, flavoprotein subunit [EC:1.3.5.1 1.3.5.4] -0.230 0.296 0.438 0.651
sdhB, frdB; succinate dehydrogenase / fumarate reductase, iron-sulfur subunit [EC:1.3.5.1 1.3.5.4] -0.230 0.296 0.438 0.651
sdhC, frdC; succinate dehydrogenase / fumarate reductase, cytochrome b subunit -0.230 0.296 0.438 0.651
secA; preprotein translocase subunit SecA -0.230 0.296 0.438 0.651
secDF; SecD/SecF fusion protein -0.230 0.296 0.438 0.651
secE; preprotein translocase subunit SecE -0.216 0.300 0.472 0.651
secG; preprotein translocase subunit SecG -0.230 0.296 0.438 0.651
secY; preprotein translocase subunit SecY -0.230 0.296 0.438 0.651
serA, PHGDH; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399] -0.228 0.293 0.436 0.651
serB, PSPH; phosphoserine phosphatase [EC:3.1.3.3] -0.237 0.319 0.459 0.651
serC, PSAT1; phosphoserine aminotransferase [EC:2.6.1.52] -0.228 0.293 0.436 0.651
SERPINB; serpin B -0.131 0.338 0.699 0.797
SIAE; sialate O-acetylesterase [EC:3.1.1.53] -0.283 0.313 0.368 0.651
SLC13A2_3_5; solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 -0.208 0.313 0.507 0.651
slo; thiol-activated cytolysin -0.154 0.385 0.690 0.797
slyD; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8] -0.230 0.296 0.438 0.651
smf; DNA processing protein -0.230 0.296 0.438 0.651
smpB; SsrA-binding protein -0.230 0.296 0.438 0.651
SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1] -0.396 0.395 0.317 0.651
speA; arginine decarboxylase [EC:4.1.1.19] -0.230 0.296 0.438 0.651
speG, SAT; diamine N-acetyltransferase [EC:2.3.1.57] -0.230 0.296 0.438 0.651
spoU; RNA methyltransferase, TrmH family -0.230 0.296 0.438 0.651
SPP; sucrose-6-phosphatase [EC:3.1.3.24] -0.208 0.288 0.471 0.651
sppA; protease IV [EC:3.4.21.-] -0.230 0.296 0.438 0.651
spsF; spore coat polysaccharide biosynthesis protein SpsF -0.319 0.983 0.746 0.834
SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4] -0.230 0.296 0.438 0.651
ssb; single-strand DNA-binding protein -0.232 0.301 0.441 0.651
sucC; succinyl-CoA synthetase beta subunit [EC:6.2.1.5] -0.173 0.329 0.600 0.723
sucD; succinyl-CoA synthetase alpha subunit [EC:6.2.1.5] -0.173 0.329 0.600 0.723
sufB; Fe-S cluster assembly protein SufB -0.230 0.296 0.438 0.651
sufC; Fe-S cluster assembly ATP-binding protein -0.230 0.296 0.438 0.651
sufD; Fe-S cluster assembly protein SufD -0.230 0.296 0.438 0.651
sufE; cysteine desulfuration protein SufE -0.230 0.296 0.438 0.651
sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16] -0.230 0.296 0.438 0.651
surA; peptidyl-prolyl cis-trans isomerase SurA [EC:5.2.1.8] -0.230 0.296 0.438 0.651
surE; 5’-nucleotidase [EC:3.1.3.5] -0.230 0.296 0.438 0.651
tadA; tRNA(adenine34) deaminase [EC:3.5.4.33] -0.230 0.296 0.438 0.651
tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] -0.227 0.333 0.497 0.651
tagD; glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39] 0.358 0.550 0.516 0.651
tagF; CDP-glycerol glycerophosphotransferase [EC:2.7.8.12] 0.092 1.404 0.948 0.986
TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3] -0.230 0.296 0.438 0.651
tatA; sec-independent protein translocase protein TatA -0.520 0.870 0.551 0.683
tatC; sec-independent protein translocase protein TatC -0.520 0.870 0.551 0.683
tatD; TatD DNase family protein [EC:3.1.21.-] -0.234 0.283 0.408 0.651
TC.AGCS; alanine or glycine:cation symporter, AGCS family -0.045 0.351 0.898 0.972
TC.BASS; bile acid:Na+ symporter, BASS family -0.228 0.293 0.437 0.651
TC.CIC; chloride channel protein, CIC family -0.230 0.296 0.438 0.651
TC.CPA1; monovalent cation:H+ antiporter, CPA1 family -2.232 1.933 0.250 0.651
TC.FEV.OM; iron complex outermembrane recepter protein -0.224 0.298 0.453 0.651
TC.FEV.OM2, cirA, cfrA, hmuR; outer membrane receptor for ferrienterochelin and colicins -0.212 0.308 0.491 0.651
TC.FEV.OM3, tbpA, hemR, lbpA, hpuB, bhuR, hugA, hmbR; hemoglobin/transferrin/lactoferrin receptor protein 0.054 0.493 0.913 0.976
TC.GPH; glycoside/pentoside/hexuronide:cation symporter, GPH family -0.606 0.561 0.282 0.651
TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family -0.216 0.278 0.438 0.651
TC.KEF; monovalent cation:H+ antiporter-2, CPA2 family -0.187 0.310 0.548 0.681
TC.MATE, SLC47A, norM, mdtK, dinF; multidrug resistance protein, MATE family -0.227 0.307 0.462 0.651
TC.NSS; neurotransmitter:Na+ symporter, NSS family -0.242 0.316 0.446 0.651
TC.PIT; inorganic phosphate transporter, PiT family 2.304 1.989 0.248 0.651
TC.POT; proton-dependent oligopeptide transporter, POT family -0.230 0.296 0.438 0.651
TC.SSS; solute:Na+ symporter, SSS family -0.692 0.616 0.263 0.651
TC.SULP; sulfate permease, SulP family -0.746 1.115 0.505 0.651
TC.ZIP, zupT, ZRT3, ZIP2; zinc transporter, ZIP family -0.247 0.568 0.664 0.776
tdk, TK; thymidine kinase [EC:2.7.1.21] -0.230 0.296 0.438 0.651
terC; tellurite resistance protein TerC -0.625 0.575 0.278 0.651
tetM, tetO; ribosomal protection tetracycline resistance protein -0.388 0.498 0.437 0.651
tex; protein Tex -0.196 0.300 0.514 0.651
tgt, QTRT1; queuine tRNA-ribosyltransferase [EC:2.4.2.29] -0.230 0.296 0.438 0.651
THI4, THI1; cysteine-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.60] 0.014 0.383 0.970 0.998
thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17] 0.014 0.383 0.970 0.998
thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7] -0.134 0.312 0.669 0.779
thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3] -0.063 0.337 0.853 0.928
thiG; thiazole synthase [EC:2.8.1.10] 18.519 3411.091 0.996 0.998
thiH; 2-iminoacetate synthase [EC:4.1.99.19] 18.519 3411.091 0.996 0.998
thiJ; protein deglycase [EC:3.5.1.124] -0.230 0.296 0.438 0.651
thiL; thiamine-monophosphate kinase [EC:2.7.4.16] -0.230 0.296 0.438 0.651
thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2] -0.198 0.307 0.519 0.653
thiS; sulfur carrier protein 18.519 3411.091 0.996 0.998
thrA; bifunctional aspartokinase / homoserine dehydrogenase 1 [EC:2.7.2.4 1.1.1.3] -0.274 0.307 0.374 0.651
thrC; threonine synthase [EC:4.2.3.1] -0.606 0.561 0.282 0.651
thyA, TYMS; thymidylate synthase [EC:2.1.1.45] -0.172 0.309 0.579 0.705
thyX, thy1; thymidylate synthase (FAD) [EC:2.1.1.148] -0.625 0.575 0.278 0.651
tig; trigger factor -0.230 0.296 0.438 0.651
tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19] -0.230 0.296 0.438 0.651
tnaA; tryptophanase [EC:4.1.99.1] -0.221 0.572 0.699 0.797
tolA; colicin import membrane protein -0.164 0.315 0.604 0.723
tolC; outer membrane protein -0.590 0.508 0.248 0.651
tonB; periplasmic protein TonB -0.185 0.276 0.505 0.651
topA; DNA topoisomerase I [EC:5.99.1.2] -0.230 0.296 0.438 0.651
topB; DNA topoisomerase III [EC:5.99.1.2] -0.314 0.345 0.363 0.651
TPI, tpiA; triosephosphate isomerase (TIM) [EC:5.3.1.1] -0.240 0.307 0.435 0.651
tpx; thiol peroxidase, atypical 2-Cys peroxiredoxin [EC:1.11.1.15] -0.754 1.120 0.502 0.651
treS; maltose alpha-D-glucosyltransferase / alpha-amylase [EC:5.4.99.16 3.2.1.1] -0.629 0.781 0.422 0.651
trkA, ktrA; trk system potassium uptake protein -0.230 0.296 0.438 0.651
trkH, trkG, ktrB; trk system potassium uptake protein -0.230 0.296 0.438 0.651
trmB, METTL1; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33] -0.230 0.296 0.438 0.651
trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228] -0.230 0.296 0.438 0.651
troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator 0.038 0.480 0.937 0.977
trpA; tryptophan synthase alpha chain [EC:4.2.1.20] -0.089 1.133 0.938 0.977
trpB; tryptophan synthase beta chain [EC:4.2.1.20] -0.229 0.301 0.447 0.651
trpC; indole-3-glycerol phosphate synthase [EC:4.1.1.48] -0.376 0.442 0.397 0.651
trpD; anthranilate phosphoribosyltransferase [EC:2.4.2.18] -0.089 1.133 0.938 0.977
trpE; anthranilate synthase component I [EC:4.1.3.27] -0.089 1.133 0.938 0.977
trpF; phosphoribosylanthranilate isomerase [EC:5.3.1.24] -0.219 0.301 0.468 0.651
trpG; anthranilate synthase component II [EC:4.1.3.27] -0.167 0.324 0.608 0.725
truA, PUS1; tRNA pseudouridine38-40 synthase [EC:5.4.99.12] -0.230 0.296 0.438 0.651
truB, PUS4, TRUB1; tRNA pseudouridine55 synthase [EC:5.4.99.25] -0.230 0.296 0.438 0.651
trxA; thioredoxin 1 -0.230 0.296 0.438 0.651
trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9] -0.230 0.296 0.438 0.651
tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB -0.230 0.296 0.438 0.651
tsaC, rimN, SUA5; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87] -0.230 0.296 0.438 0.651
tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE -0.230 0.296 0.438 0.651
tsf, TSFM; elongation factor Ts -0.230 0.296 0.438 0.651
TSTA3, fcl; GDP-L-fucose synthase [EC:1.1.1.271] -0.230 0.296 0.438 0.651
tuf, TUFM; elongation factor Tu -0.230 0.296 0.438 0.651
typA, bipA; GTP-binding protein -0.230 0.296 0.438 0.651
ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201] -0.230 0.296 0.438 0.651
udk, UCK; uridine kinase [EC:2.7.1.48] -0.230 0.296 0.438 0.651
udp, UPP; uridine phosphorylase [EC:2.4.2.3] -0.230 0.296 0.438 0.651
UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22] -0.219 0.308 0.477 0.651
umuC; DNA polymerase V -0.183 0.301 0.543 0.678
umuD; DNA polymerase V [EC:3.4.21.-] -2.933 2.379 0.219 0.651
UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27] -0.204 0.307 0.507 0.651
upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9] -0.230 0.296 0.438 0.651
uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] -0.230 0.296 0.438 0.651
URA4, pyrC; dihydroorotase [EC:3.5.2.3] -0.220 0.308 0.477 0.651
utp; urea transporter -17.599 3454.822 0.996 0.998
uup; ABC transport system ATP-binding/permease protein -0.220 0.308 0.477 0.651
uvrA; excinuclease ABC subunit A -0.215 0.290 0.459 0.651
uvrB; excinuclease ABC subunit B -0.230 0.296 0.438 0.651
uvrC; excinuclease ABC subunit C -0.230 0.296 0.438 0.651
uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12] -0.254 0.306 0.407 0.651
uxaA; altronate hydrolase [EC:4.2.1.7] -0.676 0.652 0.302 0.651
uxaB; tagaturonate reductase [EC:1.1.1.58] -0.676 0.652 0.302 0.651
uxaC; glucuronate isomerase [EC:5.3.1.12] -0.839 0.582 0.151 0.651
UXS1, uxs; UDP-glucuronate decarboxylase [EC:4.1.1.35] -0.137 0.613 0.823 0.900
uxuA; mannonate dehydratase [EC:4.2.1.8] -0.692 0.616 0.263 0.651
uxuB; fructuronate reductase [EC:1.1.1.57] -0.677 0.652 0.301 0.651
vanX; zinc D-Ala-D-Ala dipeptidase [EC:3.4.13.22] -0.199 0.288 0.490 0.651
VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9] -0.230 0.296 0.438 0.651
vsr; DNA mismatch endonuclease, patch repair protein [EC:3.1.-.-] -0.298 0.485 0.540 0.676
WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] -0.230 0.296 0.438 0.651
wbpO; UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.-] -0.076 0.332 0.819 0.899
wcaJ; putative colanic acid biosysnthesis UDP-glucose lipid carrier transferase -0.429 0.535 0.425 0.651
wcaK, amsJ; colanic acid/amylovoran biosynthesis protein 2.304 1.989 0.248 0.651
wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14] -0.287 0.294 0.330 0.651
xanP; xanthine permease XanP -0.131 0.310 0.674 0.784
xapB; MFS transporter, NHS family, xanthosine permease 0.027 0.484 0.955 0.992
xerC; integrase/recombinase XerC -0.230 0.296 0.438 0.651
xerD; integrase/recombinase XerD -0.230 0.296 0.438 0.651
xlyAB; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] -1.535 1.399 0.274 0.651
xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22] -0.156 0.300 0.605 0.723
xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6] -0.230 0.296 0.438 0.651
xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6] -0.230 0.296 0.438 0.651
xylA; xylose isomerase [EC:5.3.1.5] -0.092 1.135 0.935 0.977
xylB, XYLB; xylulokinase [EC:2.7.1.17] -0.546 0.585 0.352 0.651
xylE; MFS transporter, SP family, xylose:H+ symportor 0.154 1.349 0.909 0.976
xylS, yicI; alpha-D-xyloside xylohydrolase [EC:3.2.1.177] -0.603 0.561 0.284 0.651
yaeR; glyoxylase I family protein 18.519 3411.091 0.996 0.998
yafQ; mRNA interferase YafQ [EC:3.1.-.-] -0.737 0.680 0.280 0.651
yajC; preprotein translocase subunit YajC -0.230 0.296 0.438 0.651
YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1] -0.230 0.296 0.438 0.651
ybaK, ebsC; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-] -0.754 1.120 0.502 0.651
ybaZ; methylated-DNA-protein-cysteine methyltransferase related protein -0.213 0.325 0.513 0.651
ybdG, mscM; miniconductance mechanosensitive channel -0.223 0.302 0.460 0.651
ybeB; ribosome-associated protein -0.230 0.296 0.438 0.651
ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-] -0.370 0.319 0.249 0.651
ycaJ; putative ATPase -0.230 0.296 0.438 0.651
ychF; ribosome-binding ATPase -0.230 0.296 0.438 0.651
yfbK; Ca-activated chloride channel homolog -0.248 0.303 0.415 0.651
yfiC, trmX; tRNA1Val (adenine37-N6)-methyltransferase [EC:2.1.1.223] -0.230 0.296 0.438 0.651
yfiH; polyphenol oxidase [EC:1.10.3.-] -0.230 0.296 0.438 0.651
yggS, PROSC; PLP dependent protein -0.230 0.296 0.438 0.651
yhbH; putative sigma-54 modulation protein -0.263 0.312 0.401 0.651
yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase -0.230 0.296 0.438 0.651
yjbB; phosphate:Na+ symporter -0.230 0.296 0.438 0.651
yjdF; putative membrane protein -0.084 0.350 0.811 0.894
yoeB; toxin YoeB [EC:3.1.-.-] 0.112 0.479 0.816 0.896
ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-] -0.230 0.296 0.438 0.651
yraN; putative endonuclease -0.230 0.296 0.438 0.651
yrbG; cation:H+ antiporter -0.156 0.300 0.605 0.723
ytfE, scdA; regulator of cell morphogenesis and NO signaling -0.216 0.284 0.448 0.651
zapA; cell division protein ZapA -0.219 0.301 0.468 0.651
zntA; Cd2+/Zn2+-exporting ATPase [EC:3.6.3.3 3.6.3.5] -0.201 0.284 0.481 0.651
znuA; zinc transport system substrate-binding protein -0.352 0.456 0.441 0.651
znuB; zinc transport system permease protein -0.452 0.409 0.271 0.651
znuC; zinc transport system ATP-binding protein [EC:3.6.3.-] -0.452 0.409 0.271 0.651
zraR, hydG; two-component system, NtrC family, response regulator HydG -0.512 0.991 0.606 0.723 
# merge with tb.ra for full results table
full.res <- left_join(tb.ra, results.out, by = "description")

write.csv(full.res, "output/picrust_ko_stratefied_prevo_data_results.csv", row.names = F)

sessionInfo()
R version 4.0.5 (2021-03-31)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19042)

Matrix products: default

locale:
[1] LC_COLLATE=English_United States.1252 
[2] LC_CTYPE=English_United States.1252   
[3] LC_MONETARY=English_United States.1252
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.1252    

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] cowplot_1.1.1     dendextend_1.14.0 ggdendro_0.1.22   reshape2_1.4.4   
 [5] car_3.0-10        carData_3.0-4     gvlma_1.0.0.3     patchwork_1.1.1  
 [9] viridis_0.5.1     viridisLite_0.3.0 gridExtra_2.3     xtable_1.8-4     
[13] kableExtra_1.3.4  MASS_7.3-53.1     data.table_1.14.0 readxl_1.3.1     
[17] forcats_0.5.1     stringr_1.4.0     dplyr_1.0.5       purrr_0.3.4      
[21] readr_1.4.0       tidyr_1.1.3       tibble_3.1.0      ggplot2_3.3.3    
[25] tidyverse_1.3.0   lmerTest_3.1-3    lme4_1.1-26       Matrix_1.3-2     
[29] vegan_2.5-7       lattice_0.20-41   permute_0.9-5     phyloseq_1.34.0  
[33] workflowr_1.6.2  

loaded via a namespace (and not attached):
  [1] minqa_1.2.4         colorspace_2.0-0    rio_0.5.26         
  [4] ellipsis_0.3.1      rprojroot_2.0.2     XVector_0.30.0     
  [7] fs_1.5.0            rstudioapi_0.13     farver_2.1.0       
 [10] fansi_0.4.2         lubridate_1.7.10    xml2_1.3.2         
 [13] codetools_0.2-18    splines_4.0.5       knitr_1.31         
 [16] ade4_1.7-16         jsonlite_1.7.2      nloptr_1.2.2.2     
 [19] broom_0.7.5         cluster_2.1.1       dbplyr_2.1.0       
 [22] BiocManager_1.30.10 compiler_4.0.5      httr_1.4.2         
 [25] backports_1.2.1     assertthat_0.2.1    cli_2.3.1          
 [28] later_1.1.0.1       htmltools_0.5.1.1   prettyunits_1.1.1  
 [31] tools_4.0.5         igraph_1.2.6        gtable_0.3.0       
 [34] glue_1.4.2          Rcpp_1.0.6          Biobase_2.50.0     
 [37] cellranger_1.1.0    jquerylib_0.1.3     vctrs_0.3.6        
 [40] Biostrings_2.58.0   rhdf5filters_1.2.0  multtest_2.46.0    
 [43] svglite_2.0.0       ape_5.4-1           nlme_3.1-152       
 [46] iterators_1.0.13    xfun_0.21           ps_1.6.0           
 [49] openxlsx_4.2.3      rvest_1.0.0         lifecycle_1.0.0    
 [52] statmod_1.4.35      zlibbioc_1.36.0     scales_1.1.1       
 [55] hms_1.0.0           promises_1.2.0.1    parallel_4.0.5     
 [58] biomformat_1.18.0   rhdf5_2.34.0        curl_4.3           
 [61] yaml_2.2.1          sass_0.3.1          stringi_1.5.3      
 [64] highr_0.8           S4Vectors_0.28.1    foreach_1.5.1      
 [67] BiocGenerics_0.36.0 zip_2.1.1           boot_1.3-27        
 [70] systemfonts_1.0.1   rlang_0.4.10        pkgconfig_2.0.3    
 [73] evaluate_0.14       Rhdf5lib_1.12.1     labeling_0.4.2     
 [76] tidyselect_1.1.0    plyr_1.8.6          magrittr_2.0.1     
 [79] R6_2.5.0            IRanges_2.24.1      generics_0.1.0     
 [82] DBI_1.1.1           foreign_0.8-81      pillar_1.5.1       
 [85] haven_2.3.1         whisker_0.4         withr_2.4.1        
 [88] mgcv_1.8-34         abind_1.4-5         survival_3.2-10    
 [91] modelr_0.1.8        crayon_1.4.1        utf8_1.1.4         
 [94] rmarkdown_2.7       progress_1.2.2      grid_4.0.5         
 [97] git2r_0.28.0        webshot_0.5.2       reprex_1.0.0       
[100] digest_0.6.27       httpuv_1.5.5        numDeriv_2016.8-1.1
[103] stats4_4.0.5        munsell_0.5.0       bslib_0.2.4