PICRUSt Stratified Analyses

Fusobacterium nucleatum

workflowr

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Last updated: 2021-04-15

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i. Mean relative abundance in Tumors

ii. Standard error of mean in Tumors

iii. Mean relative abundance in Non-tumors

iv. Standard error of mean in Non-tumors

v. GLM differential abundance analysis between Tumor vs Non-tumor (Patient=Fixed effect)
  1. P-value
  2. FDR corrected q-value
vi. GLMM differential abundance analysis between Tumor vs Non-tumor (Patient=Random Effect)
  1.P-value
  2. FDR corrected q-value

Part 1 EC Data

# note: must rename function to func (or something else) because "function" is a reserved name in R and can't be used.

descriptions <- readr::read_tsv("data/PICRUST/ec_pred_metagenome_unstrat_descrip.tsv")[,1:2] %>%
  distinct()

-- Column specification --------------------------------------------------------
cols(
  .default = col_double(),
  `function` = col_character(),
  description = col_character()
)
i Use `spec()` for the full column specifications.

colnames(descriptions) <- c("func", "description")

pi.dat <- readxl::read_xlsx("data/PICRUST-Stratified/EC_fuso.xlsx")
colnames(pi.dat) <- c("func",  colnames(pi.dat)[-c(1)])

# add descriptions to dataframe
pi.dat <- left_join(pi.dat, descriptions, by="func")
pi.dat <- pi.dat[,c(1,161,3:160)]

# aggregate descriptions to get 1 description per row - unique;y defined.
pi.dat <- pi.dat %>%
  group_by(description) %>%
  summarise(across(`1.S37.Jun172016`:`99.D01.S37.Jun232016`,.fns = mean))

# make long format
pi.dat <- pi.dat %>%
  pivot_longer(
    cols=`1.S37.Jun172016`:`99.D01.S37.Jun232016`,
    names_to = "ID",
    values_to = "Abundance"
  )
d <- as.data.frame(dat.16s)
mydata <- full_join(pi.dat, d)

Joining, by = "ID"

Warning in class(x) <- c(setdiff(subclass, tibble_class), tibble_class): Setting
class(x) to multiple strings ("tbl_df", "tbl", ...); result will no longer be an
S4 object

mydata <- mydata %>%
  mutate(
    ID.n = as.numeric(as.factor(ID)),
    description.n = as.numeric(as.factor(description))
  ) %>%
  group_by(description)%>%
  mutate(avgA = mean(Abundance))

Abundance

I needed to change from relative abundance to abundance due to so many individuals having 0 counts for all descriptions.

# Test-1
d <- mydata %>%
  filter(description=="Arsenite-transporting ATPase")
fit1 <- t.test(d$Abundance ~ d$tumor.cat)
fit1

    Welch Two Sample t-test

data:  d$Abundance by d$tumor.cat
t = -1.75, df = 74.9, p-value = 0.085
alternative hypothesis: true difference in means is not equal to 0
95 percent confidence interval:
 -66.7110   4.3825
sample estimates:
mean in group Non-Tumor     mean in group Tumor 
                 10.774                  41.938 

fit1$stderr 

[1] 17.843

# Test-2
d <- mydata %>%
  filter(description=="Gamma-glutamyltransferase")
fit2 <- t.test(d$Abundance ~ d$tumor.cat)
fit2

    Welch Two Sample t-test

data:  d$Abundance by d$tumor.cat
t = -1.75, df = 74.9, p-value = 0.085
alternative hypothesis: true difference in means is not equal to 0
95 percent confidence interval:
 -66.7110   4.3825
sample estimates:
mean in group Non-Tumor     mean in group Tumor 
                 10.774                  41.938 

fit2$stderr

[1] 17.843

# Run on all descriptions
tb.ra1 <- mydata %>%
  group_by(description) %>%
  summarise(ng = n(),
            Overall.M = mean(Abundance),
            Overall.SE = sd(Abundance)/sqrt(ng))
tb.ra2m <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(M = mean(Abundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = M)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2se <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(),SE = sd(Abundance)/sqrt(ng)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = SE)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2var <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(), VAR = var(Abundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = VAR)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2ng <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n()) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = ng)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra <- left_join(tb.ra1, tb.ra2m)

Joining, by = "description"

tb.ra <- cbind(tb.ra, tb.ra2se[,-1])
tb.ra <- cbind(tb.ra, tb.ra2var[,-1])
tb.ra <- cbind(tb.ra, tb.ra2ng[,-1]) 

colnames(tb.ra) <- c("description", "ng", "Overall Mean", "Overall SE", "Non-Tumor Mean", "Tumor Mean", "Non-Tumor SE", "Tumor SE","Non-Tumor Var", "Tumor Var", "Non-Tumor Ng", "Tumor Ng")
tb.ra <- tb.ra %>%
  arrange(desc(`Overall Mean`))
tb.ra <- tb.ra[, c("description", "Overall Mean", "Overall SE","Tumor Mean","Tumor Var", "Tumor SE","Tumor Ng", "Non-Tumor Mean","Non-Tumor Var", "Non-Tumor SE", "Non-Tumor Ng")]

# compute t-test
tb.ra <- tb.ra %>%
  mutate(
    SEpooled = sqrt(`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`),
    t = (`Tumor Mean` - `Non-Tumor Mean`)/(SEpooled),
    df = ((`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`)**2)/(((`Tumor Var`/`Tumor Ng`)**2)/(`Tumor Ng`-1) + ((`Non-Tumor Var`/`Non-Tumor Ng`)**2)/(`Non-Tumor Ng`-1)),
    p = pt(q = abs(t), df=df, lower.tail = F)*2,
    fdr_p = p.adjust(p, method="fdr")
  )



kable(tb.ra, format="html", digits=5, caption="Stratefied EC Data - Fusobacterium nucleatum: Average Abundance of Each Description (sorted in descending order)") %>%
  kable_styling(full_width = T) %>%
  scroll_box(width = "100%", height="600px")

Stratefied EC Data - Fusobacterium nucleatum: Average Abundance of Each Description (sorted in descending order)

description	Overall Mean	Overall SE	Tumor Mean	Tumor Var	Tumor SE	Tumor Ng	Non-Tumor Mean	Non-Tumor Var	Non-Tumor SE	Non-Tumor Ng	SEpooled	t	df	p	fdr_p
Arsenite-transporting ATPase	23.59494	7.69896	41.93846	19087.49615	17.13633	65	10.77419	2299.91585	4.97295	93	17.84332	1.74655	74.864	0.08482	0.11963
Gamma-glutamyltransferase	23.59494	7.69896	41.93846	19087.49615	17.13633	65	10.77419	2299.91585	4.97295	93	17.84332	1.74655	74.864	0.08482	0.11963
Glutathione hydrolase	23.59494	7.69896	41.93846	19087.49615	17.13633	65	10.77419	2299.91585	4.97295	93	17.84332	1.74655	74.864	0.08482	0.11963
DNA helicase	17.75000	5.06063	29.36923	7903.43380	11.02684	65	9.62903	1245.12447	3.65902	93	11.61808	1.69909	78.210	0.09328	0.11963
DNA-directed DNA polymerase	16.27532	4.58797	26.74808	6449.43090	9.96102	65	8.95565	1057.35891	3.37186	93	10.51625	1.69190	78.788	0.09462	0.12092
(S)-2-hydroxy-acid oxidase	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11963
1,4-dihydroxy-2-naphthoate polyprenyltransferase	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11963
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11963
D-serine ammonia-lyase	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11963
Demethylmenaquinone methyltransferase	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11963
Diamine N-acetyltransferase	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11963
Formylmethanofuran dehydrogenase	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11963
Gluconate 5-dehydrogenase	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11963
Hydroxymethylglutaryl-CoA lyase	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11963
Isocitrate dehydrogenase (NAD(+))	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11963
L-rhamnonate dehydratase	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11963
S-methyl-5-thioribose-1-phosphate isomerase	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11963
S-methyl-5-thioribose kinase	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11963
Sulfoacetaldehyde dehydrogenase (acylating)	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11963
Iron-chelate-transporting ATPase	11.59968	3.45917	19.74038	3775.28628	7.62111	65	5.90995	520.52934	2.36582	93	7.97988	1.73316	76.435	0.08710	0.11963
Protein-N(pi)-phosphohistidine–sugar phosphotransferase	9.73165	2.67373	15.20500	2065.17055	5.63665	65	5.90618	454.95005	2.21177	93	6.05506	1.53571	83.843	0.12837	0.15690
Pyruvate synthase	9.44873	2.92620	16.35846	2731.95661	6.48306	65	4.61935	350.94940	1.94259	93	6.76785	1.73454	75.584	0.08690	0.11963
Peptidylprolyl isomerase	8.54114	2.49038	14.46538	1948.21753	5.47472	65	4.40054	274.83239	1.71907	93	5.73827	1.75399	76.724	0.08343	0.11963
DNA-directed RNA polymerase	7.10000	2.02425	11.74769	1264.54941	4.41074	65	3.85161	199.21992	1.46361	93	4.64723	1.69909	78.210	0.09328	0.11963
Type I site-specific deoxyribonuclease	6.72627	1.98184	11.50385	1235.73875	4.36020	65	3.38710	171.97726	1.35986	93	4.56734	1.77713	76.552	0.07952	0.11963
Acetate CoA-transferase	6.49937	1.96656	11.11615	1225.80485	4.34264	65	3.27258	164.44101	1.32973	93	4.54166	1.72703	76.099	0.08822	0.11963
Butyrate–acetoacetate CoA-transferase	6.49937	1.96656	11.11615	1225.80485	4.34264	65	3.27258	164.44101	1.32973	93	4.54166	1.72703	76.099	0.08822	0.11963
L-fuculose-phosphate aldolase	6.33544	1.97139	10.61538	1212.67788	4.31933	65	3.34409	182.29880	1.40007	93	4.54057	1.60141	77.560	0.11335	0.14004
Shikimate dehydrogenase	6.27468	1.94810	10.92962	1211.22070	4.31673	65	3.02124	154.67310	1.28963	93	4.50525	1.75537	75.516	0.08325	0.11963
Ethanolamine ammonia-lyase	6.20127	1.94264	11.00154	1203.15390	4.30233	65	2.84624	152.91012	1.28226	93	4.48935	1.81659	75.461	0.07325	0.11963
Nickel-transporting ATPase	6.20127	1.94264	11.00154	1203.15390	4.30233	65	2.84624	152.91012	1.28226	93	4.48935	1.81659	75.461	0.07325	0.11963
Cystathionine gamma-synthase	6.05000	1.93322	10.74308	1197.49116	4.29220	65	2.76989	148.22957	1.26248	93	4.47401	1.78211	75.162	0.07877	0.11963
Formimidoyltetrahydrofolate cyclodeaminase	6.05000	1.93322	10.74308	1197.49116	4.29220	65	2.76989	148.22957	1.26248	93	4.47401	1.78211	75.162	0.07877	0.11963
Glutamate formimidoyltransferase	6.05000	1.93322	10.74308	1197.49116	4.29220	65	2.76989	148.22957	1.26248	93	4.47401	1.78211	75.162	0.07877	0.11963
Site-specific DNA-methyltransferase (adenine-specific)	5.70728	1.55147	9.37692	736.54370	3.36622	65	3.14247	120.47337	1.13816	93	3.55343	1.75449	78.753	0.08324	0.11963
Coproporphyrinogen dehydrogenase	5.54968	1.54748	8.99731	724.52992	3.33865	65	3.14005	127.39306	1.17039	93	3.53786	1.65559	79.858	0.10173	0.12733
Asparaginyl-tRNA synthase (glutamine-hydrolyzing)	5.32500	1.51819	8.81077	711.30904	3.30805	65	2.88871	112.06120	1.09771	93	3.48542	1.69909	78.210	0.09328	0.11963
Glutaminyl-tRNA synthase (glutamine-hydrolyzing)	5.32500	1.51819	8.81077	711.30904	3.30805	65	2.88871	112.06120	1.09771	93	3.48542	1.69909	78.210	0.09328	0.11963
Cystathionine beta-lyase	5.20949	1.50878	8.65692	703.04315	3.28878	65	2.80000	110.45380	1.08981	93	3.46464	1.69049	78.171	0.09492	0.12092
H(+)-transporting two-sector ATPase	5.20949	1.50878	8.65692	703.04315	3.28878	65	2.80000	110.45380	1.08981	93	3.46464	1.69049	78.171	0.09492	0.12092
Non-specific serine/threonine protein kinase	5.13386	1.50356	8.52769	700.42656	3.28265	65	2.76183	108.47514	1.08000	93	3.45575	1.66849	77.969	0.09923	0.12447
Exodeoxyribonuclease VII	5.10032	1.49320	8.62423	698.94277	3.27917	65	2.63737	100.05373	1.03723	93	3.43930	1.74072	76.912	0.08573	0.11963
Cob(I)yrinic acid a,c-diamide adenosyltransferase	5.06677	1.48668	8.72077	697.71417	3.27629	65	2.51290	94.55199	1.00831	93	3.42794	1.81096	76.222	0.07409	0.11963
Inorganic diphosphatase	5.02468	1.48807	8.49500	696.41057	3.27323	65	2.59919	98.13895	1.02726	93	3.43064	1.71858	76.710	0.08973	0.11963
Long-chain-fatty-acid–CoA ligase	5.02468	1.48807	8.49500	696.41057	3.27323	65	2.59919	98.13895	1.02726	93	3.43064	1.71858	76.710	0.08973	0.11963
Short-chain acyl-CoA dehydrogenase	5.02468	1.48807	8.49500	696.41057	3.27323	65	2.59919	98.13895	1.02726	93	3.43064	1.71858	76.710	0.08973	0.11963
Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)	5.01468	1.56089	8.64677	772.73953	3.44794	65	2.47613	103.52967	1.05509	93	3.60576	1.71133	76.083	0.09109	0.11963
Cysteine–tRNA ligase	4.87563	1.47273	8.43769	687.43112	3.25206	65	2.38602	91.37064	0.99120	93	3.39976	1.78003	75.987	0.07907	0.11963
Ribosomal-protein-alanine N-acetyltransferase	4.80000	1.46776	8.30846	685.06762	3.24646	65	2.34785	89.52953	0.98116	93	3.39149	1.75752	75.786	0.08287	0.11963
Histidine kinase	4.19051	1.09741	6.53000	344.87946	2.30344	65	2.55538	78.23319	0.91718	93	2.47933	1.60311	84.426	0.11265	0.13947
N-acetylmuramoyl-L-alanine amidase	3.81677	1.03458	6.28615	326.76361	2.24213	65	2.09086	53.96528	0.76176	93	2.36800	1.77166	78.896	0.08031	0.11963
Acetyl-CoA carboxylase	3.77468	1.04244	6.06038	325.09371	2.23639	65	2.17715	60.58028	0.80709	93	2.37757	1.63328	80.803	0.10630	0.13247
Cysteine synthase	3.76203	1.12515	6.61011	401.30779	2.48475	65	1.77143	52.43381	0.75087	93	2.59572	1.86410	75.783	0.06618	0.11963
DNA-(apurinic or apyrimidinic site) lyase	3.70127	1.02383	6.13231	320.49863	2.22053	65	2.00215	52.58673	0.75196	93	2.34440	1.76171	78.800	0.08200	0.11963
Aminodeoxychorismate synthase	3.67559	1.11913	6.46242	398.97632	2.47752	65	1.72780	50.82876	0.73929	93	2.58547	1.83124	75.488	0.07101	0.11963
Monosaccharide-transporting ATPase	3.66551	1.02272	6.02769	322.23369	2.22653	65	2.01452	51.16393	0.74172	93	2.34683	1.71004	78.322	0.09122	0.11963
Lactaldehyde reductase	3.58915	1.11363	6.31473	397.01713	2.47143	65	1.68418	49.28762	0.72799	93	2.57642	1.79728	75.194	0.07631	0.11963
[Formate-C-acetyltransferase]-activating enzyme	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
23S rRNA pseudouridine(1911/1915/1917) synthase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Adenosylcobyric acid synthase (glutamine-hydrolyzing)	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
ADP-ribose diphosphatase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Alanine–tRNA ligase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Alanine racemase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Beta-lysine 5,6-aminomutase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Carbamoyl-phosphate synthase (glutamine-hydrolyzing)	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
D-lactate dehydrogenase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
DNA topoisomerase (ATP-hydrolyzing)	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
dTDP-glucose 4,6-dehydratase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Fructose-bisphosphatase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Glucose-1-phosphate adenylyltransferase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Glutaconate CoA-transferase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Glycerol-3-phosphate 1-O-acyltransferase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Glycine–tRNA ligase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
GTP diphosphokinase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
N(6)-L-threonylcarbamoyladenine synthase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Oxaloacetate decarboxylase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Phenylalanine–tRNA ligase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Ribonucleoside-diphosphate reductase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Thioredoxin-disulfide reductase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Transketolase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
UDP-glucose 4-epimerase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Xaa-Pro aminopeptidase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11963
Fe(3+)-transporting ATPase	3.44082	0.99758	5.84115	313.42266	2.19588	65	1.76317	43.37766	0.68295	93	2.29963	1.77332	76.483	0.08016	0.11963
Methylaspartate mutase	3.44082	0.99758	5.84115	313.42266	2.19588	65	1.76317	43.37766	0.68295	93	2.29963	1.77332	76.483	0.08016	0.11963
Peptide-methionine (S)-S-oxide reductase	3.44082	0.99758	5.84115	313.42266	2.19588	65	1.76317	43.37766	0.68295	93	2.29963	1.77332	76.483	0.08016	0.11963
1-deoxy-D-xylulose-5-phosphate synthase	3.43449	1.00296	5.72000	310.74391	2.18648	65	1.83710	48.79085	0.72432	93	2.30333	1.68578	78.163	0.09583	0.12127
CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase	3.43449	1.00296	5.72000	310.74391	2.18648	65	1.83710	48.79085	0.72432	93	2.30333	1.68578	78.163	0.09583	0.12127
Phosphatidate cytidylyltransferase	3.43449	1.00296	5.72000	310.74391	2.18648	65	1.83710	48.79085	0.72432	93	2.30333	1.68578	78.163	0.09583	0.12127
8-oxo-dGTP diphosphatase	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11963
Adenine phosphoribosyltransferase	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11963
Beta-ketoacyl-[acyl-carrier-protein] synthase III	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11963
dTDP-4-dehydrorhamnose 3,5-epimerase	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11963
Glycerophosphodiester phosphodiesterase	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11963
Lactoylglutathione lyase	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11963
Peptide-methionine (R)-S-oxide reductase	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11963
Thiamine-phosphate diphosphorylase	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11963
Uracil phosphoribosyltransferase	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11963
Endopeptidase La	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11963
Heptaprenyl diphosphate synthase	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11963
Histidine ammonia-lyase	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11963
Imidazolonepropionase	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11963
Phosphoribosylglycinamide formyltransferase	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11963
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11963
Urocanate hydratase	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11963
5’ to 3’ exodeoxyribonuclease (nucleoside 3’-phosphate-forming)	3.18038	0.97932	5.55000	307.96328	2.17667	65	1.52419	37.61829	0.63600	93	2.26768	1.77529	75.014	0.07991	0.11963
2’,3’-cyclic-nucleotide 3’-phosphodiesterase	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11963
4-nitrophenylphosphatase	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11963
Ceramide glucosyltransferase	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11963
Dipeptidase E	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11963
Dolichyl-phosphate beta-D-mannosyltransferase	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11963
Nitrogenase	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11963
Nitronate monooxygenase	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11963
Phosphoenolpyruvate carboxykinase (ATP)	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11963
Phosphonate-transporting ATPase	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11963
Prolyl aminopeptidase	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11963
Triacylglycerol lipase	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11963
Tryptophan synthase	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11963
4-hydroxy-tetrahydrodipicolinate synthase	2.90380	0.81955	4.73846	208.30365	1.79016	65	1.62151	32.15518	0.58801	93	1.88426	1.65421	77.924	0.10211	0.12752
Aspartyl aminopeptidase	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12434
Phosphoglycerate dehydrogenase	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12434
Tyrosine phenol-lyase	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12434
Acetolactate synthase	2.12224	0.58474	3.64264	107.12750	1.28379	65	1.05960	14.89465	0.40020	93	1.34472	1.92087	76.540	0.05847	0.11963
Chorismate mutase	2.11519	0.55272	3.27731	87.65935	1.16129	65	1.30296	19.77103	0.46108	93	1.24948	1.58014	84.311	0.11782	0.14524
Polar-amino-acid-transporting ATPase	2.07532	0.54546	3.25269	84.98520	1.14344	65	1.25242	19.43910	0.45719	93	1.23146	1.62431	84.595	0.10803	0.13404
Ribonuclease H	2.07532	0.54546	3.25269	84.98520	1.14344	65	1.25242	19.43910	0.45719	93	1.23146	1.62431	84.595	0.10803	0.13404
Fumarate reductase (quinol)	2.03580	0.57821	3.49495	105.70350	1.27523	65	1.01598	14.05696	0.38878	93	1.33318	1.85945	75.993	0.06683	0.11963
2-iminoacetate synthase	1.99968	0.53933	3.12346	83.72617	1.13494	65	1.21425	18.66999	0.44805	93	1.22018	1.56469	84.083	0.12141	0.14871
Biotin synthase	1.99968	0.53933	3.12346	83.72617	1.13494	65	1.21425	18.66999	0.44805	93	1.22018	1.56469	84.083	0.12141	0.14871
Phosphoglycerate mutase (2,3-diphosphoglycerate-independent)	1.99968	0.53933	3.12346	83.72617	1.13494	65	1.21425	18.66999	0.44805	93	1.22018	1.56469	84.083	0.12141	0.14871
Repressor LexA	1.99024	0.57132	3.46681	102.81491	1.25768	65	0.95822	13.86942	0.38618	93	1.31564	1.90675	76.166	0.06032	0.11963
Tryptophanase	1.99024	0.57132	3.46681	102.81491	1.25768	65	0.95822	13.86942	0.38618	93	1.31564	1.90675	76.166	0.06032	0.11963
Glutamate racemase	1.96614	0.52335	3.22000	83.43288	1.13295	65	1.08978	13.92216	0.38691	93	1.19720	1.77933	79.051	0.07903	0.11963
[Citrate (pro-3S)-lyase] ligase	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11963
2.7.11.30 and 2.7.12.1	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11963
Aminodeoxychorismate lyase	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11963
Beta-lactamase	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11963
Citrate lyase holo-[acyl-carrier protein] synthase	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11963
Glycerate dehydrogenase	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11963
Ornithine decarboxylase	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11963
Triphosphoribosyl-dephospho-CoA synthase	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11963
dTDP-4-dehydrorhamnose reductase	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11963
Fructose-bisphosphate aldolase	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11963
Glucokinase	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11963
Orotidine-5’-phosphate decarboxylase	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11963
Phosphoenolpyruvate–protein phosphotransferase	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11963
Pyridoxal 5’-phosphate synthase (glutamine hydrolyzing)	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11963
tRNA (guanine(46)-N(7))-methyltransferase	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11963
UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11963
Arsenate reductase (glutaredoxin)	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11963
Crossover junction endodeoxyribonuclease	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11963
Cysteine desulfurase	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11963
DNA topoisomerase	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11963
Homoserine kinase	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11963
Kdo(2)-lipid IV(A) lauroyltransferase	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11963
Phosphate acetyltransferase	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11963
Threonine ammonia-lyase	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11963
(2E,6E)-farnesyl diphosphate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
(FADH(2)-oxidizing)	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
[Acyl-carrier-protein] S-malonyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
1-deoxy-D-xylulose-5-phosphate reductoisomerase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
1-phosphofructokinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
1,4-alpha-glucan branching enzyme	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
16S rRNA (cytidine(1402)-2’-O)-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
16S rRNA (cytidine(1409)-2’-O)-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
16S rRNA (cytosine(1402)-N(4))-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
16S rRNA (cytosine(967)-C(5))-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
16S rRNA (guanine(1207)-N(2))-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
16S rRNA (guanine(527)-N(7))-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
16S rRNA (uracil(1498)-N(3))-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
16S rRNA pseudouridine(516) synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
2-iminobutanoate/2-iminopropanoate deaminase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
23S rRNA (adenine(2503)-C(2))-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
23S rRNA (cytidine(1920)-2’-O)-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
23S rRNA (cytosine(1962)-C(5))-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
23S rRNA (guanosine(2251)-2’-O)-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
23S rRNA (pseudouridine(1915)-N(3))-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
23S rRNA (uracil(1939)-C(5))-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
23S rRNA pseudouridine(2605) synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
23S rRNA pseudouridine(955/2504/2580) synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
3’(2’),5’-bisphosphate nucleotidase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
3-aminobutyryl-CoA ammonia-lyase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
3-dehydroquinate dehydratase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
3-deoxy-7-phosphoheptulonate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
3-deoxy-8-phosphooctulonate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
3-deoxy-manno-octulosonate-8-phosphatase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
3-deoxy-manno-octulosonate cytidylyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
3-hydroxyacyl-[acyl-carrier-protein] dehydratase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
3-hydroxybutyryl-CoA dehydrogenase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
3-oxoacyl-[acyl-carrier-protein] reductase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
3-phosphoshikimate 1-carboxyvinyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
3,4-dihydroxy-2-butanone-4-phosphate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
4-alpha-glucanotransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
5-(carboxyamino)imidazole ribonucleotide mutase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
5-amino-6-(5-phosphoribosylamino)uracil reductase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
5-formyltetrahydrofolate cyclo-ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
6-phosphofructokinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
6,7-dimethyl-8-ribityllumazine synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
8-amino-7-oxononanoate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Acetate kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Acetyl-CoA C-acetyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
acetylglucosaminyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Acyl-[acyl-carrier-protein]–UDP-N-acetylglucosamine O-acyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Acylaminoacyl-peptidase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Adenosylcobalamin/alpha-ribazole phosphatase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Adenosylcobinamide-GDP ribazoletransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Adenosylcobinamide-phosphate guanylyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Adenosylcobinamide-phosphate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Adenosylcobinamide kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Adenosylhomocysteine nucleosidase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Adenosylmethionine–8-amino-7-oxononanoate transaminase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Adenylate kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Adenylosuccinate lyase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Adenylosuccinate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
ADP-glyceromanno-heptose 6-epimerase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Aldose 1-epimerase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Amidophosphoribosyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Aminoacyl-tRNA hydrolase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Arabinose-5-phosphate isomerase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Arginine–tRNA ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Aromatic-amino-acid transaminase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Asparaginase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Asparagine–tRNA ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Aspartate–ammonia ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Aspartate–tRNA ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Aspartate carbamoyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Aspartate transaminase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Beta-ketoacyl-[acyl-carrier-protein] synthase II	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Biotin–[acetyl-CoA-carboxylase] ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
C-terminal processing peptidase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Cadmium-exporting ATPase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Caffeoyl-CoA O-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Calcium-transporting ATPase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Carboxypeptidase Taq	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
CCA tRNA nucleotidyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
CDP-diacylglycerol–serine O-phosphatidyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Chorismate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Citrate CoA-transferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Citryl-CoA lyase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Cobalt-factor II C(20)-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Cobalt-precorrin-4 methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Cobalt-precorrin-5B (C(1))-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Cobalt-precorrin-6A reductase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Cobalt-precorrin-6B (C(15))-methyltransferase (decarboxylating)	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Cobalt-precorrin-7 (C(5))-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Cobalt-precorrin-8 methylmutase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Cobalt-precorrin 5A hydrolase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Cobyrinate a,c-diamide synthase (glutamine-hydrolyzing)	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Cu(+) exporting ATPase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
D-alanine–D-alanine ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
D-sedoheptulose 7-phosphate isomerase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
dCMP deaminase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Dephospho-CoA kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Dethiobiotin synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Diadenylate cyclase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Diaminohydroxyphosphoribosylaminopyrimidine deaminase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Dihydrofolate reductase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Dihydrofolate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Dihydroneopterin aldolase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Dihydroorotase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Dihydroorotate dehydrogenase (NAD(+))	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Dihydropteroate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Dimethylallyltranstransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
diphosphate specific)	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
DNA ligase (NAD(+))	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
dTMP kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
dUTP diphosphatase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Endopeptidase Clp	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Enoyl-[acyl-carrier-protein] reductase (NADH)	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Enoyl-CoA hydratase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Exodeoxyribonuclease III	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Exopolyphosphatase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
FAD synthetase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Formate–tetrahydrofolate ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Formate C-acetyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Formimidoylglutamase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Galactokinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Geranylgeranyl diphosphate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glucosamine-1-phosphate N-acetyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glucosamine-6-phosphate deaminase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glucose-6-phosphate isomerase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glutaconyl-CoA decarboxylase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glutamate–tRNA ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glutamate-1-semialdehyde 2,1-aminomutase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glutamate dehydrogenase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glutaminase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glutamine–fructose-6-phosphate transaminase (isomerizing)	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glutamyl-tRNA reductase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glutathione peroxidase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glycerol-3-phosphate cytidylyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glycerol-3-phosphate dehydrogenase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glycerol-3-phosphate dehydrogenase (NAD(P)(+))	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glycerol kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Glycogen phosphorylase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
GMP synthase (glutamine-hydrolyzing)	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
GTP cyclohydrolase I	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
GTP cyclohydrolase II	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Guanosine-3’,5’-bis(diphosphate) 3’-diphosphatase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Guanosine-5’-triphosphate,3’-diphosphate diphosphatase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Guanylate kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Histidine–tRNA ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Histidinol-phosphatase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Holo-[acyl-carrier-protein] synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Hydroxyacylglutathione hydrolase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Hydroxylamine reductase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Hydroxymethylbilane synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Hydroxymethylpyrimidine kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Hypoxanthine phosphoribosyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
IMP cyclohydrolase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
IMP dehydrogenase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Isoleucine–tRNA ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
L-aspartate oxidase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
L-erythro-3,5-diaminohexanoate dehydrogenase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
L-lactate dehydrogenase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
L-serine ammonia-lyase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
L-threonine aldolase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
L-threonylcarbamoyladenylate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Leucine–tRNA ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Leucyl aminopeptidase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Lipid-A-disaccharide synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Lysine–tRNA ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Lysine 2,3-aminomutase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Malonyl-[acyl-carrier protein] O-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Methenyltetrahydrofolate cyclohydrolase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Methionine–tRNA ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Methionine adenosyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Methionine gamma-lyase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Methionine synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Methionyl-tRNA formyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Methionyl aminopeptidase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Methylated-DNA–[protein]-cysteine S-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Methylenetetrahydrofolate dehydrogenase (NADP(+))	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
N-acetylglucosamine-6-phosphate deacetylase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
N-acetylneuraminate lyase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
N-acylglucosamine-6-phosphate 2-epimerase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
NAD(+) kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
NAD(+) synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Nicotinamide-nucleotide amidase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Nicotinate-nucleotide adenylyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Nicotinate-nucleotide diphosphorylase (carboxylating)	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Nicotinate phosphoribosyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Oligonucleotidase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Orotate phosphoribosyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Pantetheine-phosphate adenylyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Pantothenate kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Peptide chain release factor N(5)-glutamine methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Peptide deformylase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Peroxiredoxin	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphatidylglycerophosphatase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphatidylserine decarboxylase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phospho-N-acetylmuramoyl-pentapeptide-transferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphoglucosamine mutase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphoglycerate kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphomethylpyrimidine kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphomethylpyrimidine synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphopantothenate–cysteine ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphopantothenoylcysteine decarboxylase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphopyruvate hydratase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphoribosylamine–glycine ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphoribosylaminoimidazolecarboxamide formyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphoribosylaminoimidazolesuccinocarboxamide synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphoribosylformylglycinamidine cyclo-ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphoribosylformylglycinamidine synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Phosphoserine phosphatase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Pimeloyl-[acyl-carrier protein] methyl ester esterase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Polyamine-transporting ATPase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Polyribonucleotide nucleotidyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Porphobilinogen synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Precorrin-2 C(20)-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Precorrin-2 dehydrogenase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Precorrin-3B C(17)-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Precorrin-4 C(11)-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Precorrin-6A reductase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Precorrin-8X methylmutase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Prepilin peptidase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Proline–tRNA ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Purine-nucleoside phosphorylase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Pyroglutamyl-peptidase I	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Pyruvate kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Pyruvate, phosphate dikinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Quinolinate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Riboflavin kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Riboflavin synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Ribonuclease III	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Ribonuclease M5	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Ribonuclease P	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Ribonucleoside-triphosphate reductase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Ribose-5-phosphate isomerase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Ribose-phosphate diphosphokinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Ribulose-phosphate 3-epimerase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
RNA helicase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
S-adenosylmethionine:tRNA ribosyltransferase-isomerase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Serine–tRNA ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Serine-type D-Ala-D-Ala carboxypeptidase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Shikimate kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Signal peptidase I	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Signal peptidase II	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Sirohydrochlorin cobaltochelatase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Sirohydrochlorin ferrochelatase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Spore photoproduct lyase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Starch synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Succinyl-diaminopimelate desuccinylase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Sulfur carrier protein ThiS adenylyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Tetraacyldisaccharide 4’-kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Tetrahydrofolate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Thiamine diphosphokinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Thiazole synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Threonine–tRNA ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Threonine-phosphate decarboxylase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Thymidylate synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Triose-phosphate isomerase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Tripeptide aminopeptidase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
tRNA-guanine(34) transglycosylase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
tRNA (cytidine(34)-2’-O)-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
tRNA (guanine(37)-N(1))-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
tRNA dimethylallyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
tRNA pseudouridine(38-40) synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
tRNA pseudouridine(55) synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
tRNA(Ile)-lysidine synthetase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Tryptophan–tRNA ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Tyrosine–tRNA ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
UDP-3-O-acyl-N-acetylglucosamine deacetylase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
UDP-glucose–hexose-1-phosphate uridylyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
UDP-N-acetylglucosamine diphosphorylase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
UDP-N-acetylmuramate–L-alanine ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
UDP-N-acetylmuramate dehydrogenase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
UDP-N-acetylmuramoyl-L-alanine–D-glutamate ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
UMP kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
UMP/CMP kinase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Undecaprenyl-diphosphate phosphatase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Uracil-DNA glycosylase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Uroporphyrinogen-III C-methyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Uroporphyrinogen-III synthase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
UTP–glucose-1-phosphate uridylyltransferase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Valine–tRNA ligase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Xaa-Pro dipeptidase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
Zinc-exporting ATPase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11963
NADH:ubiquinone reductase (H(+)-translocating)	1.12975	0.38350	1.05385	13.91698	0.46272	65	1.18280	29.96758	0.56765	93	0.73235	-0.17608	155.921	0.86046	0.87422
CoB–CoM heterodisulfide reductase	0.92405	0.31524	1.23077	22.49279	0.58825	65	0.70968	11.03436	0.34445	93	0.68168	0.76442	106.687	0.44630	0.48719
Hydrogen dehydrogenase (NADP(+))	0.92405	0.31524	1.23077	22.49279	0.58825	65	0.70968	11.03436	0.34445	93	0.68168	0.76442	106.687	0.44630	0.48719
Fumarate hydratase	0.89873	0.34114	0.74615	6.83690	0.32432	65	1.00538	26.59508	0.53476	93	0.62542	-0.41448	144.100	0.67914	0.69618
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.38363
4-hydroxybutanoyl-CoA dehydratase	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.38363
Alcohol dehydrogenase	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.38363
Arogenate dehydratase	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.38363
Dihydrolipoyl dehydrogenase	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.38363
Magnesium-importing ATPase	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.38363
Uridine phosphorylase	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.38363
Vinylacetyl-CoA Delta-isomerase	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.38363
Cyclic pyranopterin phosphate synthase	0.61603	0.21016	0.82051	9.99679	0.39217	65	0.47312	4.90416	0.22964	93	0.45446	0.76442	106.687	0.44630	0.48719
Propanediol dehydratase	0.60506	0.17366	1.03385	9.12071	0.37459	65	0.30538	1.56573	0.12975	93	0.39643	1.83759	79.483	0.06986	0.11963
(R)-2-methylmalate dehydratase	0.50970	0.12778	0.75487	4.11224	0.25153	65	0.33835	1.46968	0.12571	93	0.28119	1.48127	95.808	0.14182	0.17078
3-isopropylmalate dehydratase	0.50970	0.12778	0.75487	4.11224	0.25153	65	0.33835	1.46968	0.12571	93	0.28119	1.48127	95.808	0.14182	0.17078
(4S)-4-hydroxy-2-oxoglutarate aldolase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
[Ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
2-dehydro-3-deoxy-phosphogluconate aldolase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
2-dehydro-3-deoxygluconokinase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
6-carboxytetrahydropterin synthase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
6-pyruvoyltetrahydropterin synthase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Argininosuccinate lyase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Argininosuccinate synthase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Aspartate ammonia-lyase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Biotin carboxylase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Cytidine deaminase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Deoxyribose-phosphate aldolase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Diacylglycerol kinase (ATP)	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Diaminopimelate epimerase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Glucose-1-phosphate thymidylyltransferase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Glutamate synthase (NADH)	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Glutamate synthase (NADPH)	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Glycerate 3-kinase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Glycine hydroxymethyltransferase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Malate dehydrogenase (oxaloacetate-decarboxylating)	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Mannose-6-phosphate isomerase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Phosphate-transporting ATPase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Prephenate dehydratase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Propionate CoA-transferase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Pyridoxal kinase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Superoxide reductase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Tetrahydrodipicolinate N-acetyltransferase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
tRNA nucleotidyltransferase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Uridine kinase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
Xanthine phosphoribosyltransferase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
XTP/dITP diphosphatase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69618
D-ornithine 4,5-aminomutase	0.40338	0.11577	0.68923	4.05365	0.24973	65	0.20358	0.69588	0.08650	93	0.26428	1.83759	79.483	0.06986	0.11963
UDP-N-acetylglucosamine kinase	0.40338	0.11577	0.68923	4.05365	0.24973	65	0.20358	0.69588	0.08650	93	0.26428	1.83759	79.483	0.06986	0.11963
4-hydroxythreonine-4-phosphate dehydrogenase	0.36962	0.16316	0.32385	1.18548	0.13505	65	0.40161	6.35035	0.26131	93	0.29415	-0.26438	133.970	0.79189	0.80598
Diaminopropionate ammonia-lyase	0.36962	0.16316	0.32385	1.18548	0.13505	65	0.40161	6.35035	0.26131	93	0.29415	-0.26438	133.970	0.79189	0.80598
DNA (cytosine-5-)-methyltransferase	0.36962	0.16316	0.32385	1.18548	0.13505	65	0.40161	6.35035	0.26131	93	0.29415	-0.26438	133.970	0.79189	0.80598
Serine O-acetyltransferase	0.36962	0.16316	0.32385	1.18548	0.13505	65	0.40161	6.35035	0.26131	93	0.29415	-0.26438	133.970	0.79189	0.80598
Type III site-specific deoxyribonuclease	0.35570	0.08414	0.54974	1.93803	0.17267	65	0.22007	0.51532	0.07444	93	0.18803	1.75326	87.887	0.08304	0.11963
4-hydroxy-tetrahydrodipicolinate reductase	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88029
Aspartate-semialdehyde dehydrogenase	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88029
Aspartate kinase	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88029
Branched-chain-amino-acid transaminase	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88029
Glutamate–ammonia ligase	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88029
Homoserine dehydrogenase	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88029
Methylenetetrahydrofolate reductase (NAD(P)H)	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88029
N-acyl-D-amino-acid deacylase	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88029
Threonine synthase	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88029
1-acylglycerol-3-phosphate O-acyltransferase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
2-deoxy-D-gluconate 3-dehydrogenase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
2-phosphosulfolactate phosphatase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
23S rRNA (guanine(745)-N(1))-methyltransferase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
3-hydroxybutyryl-CoA dehydratase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
5-dehydro-4-deoxy-D-glucuronate isomerase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
6-phospho-beta-glucosidase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
7-carboxy-7-deazaguanine synthase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
7-cyano-7-deazaguanine synthase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Adenine deaminase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Altronate dehydratase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Beta-fructofuranosidase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Carbon-monoxide dehydrogenase (acceptor)	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Carbonate dehydratase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
CTP synthase (glutamine hydrolyzing)	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
D-ribose pyranase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Deoxyribonuclease IV	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Diaminopimelate decarboxylase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Dihydropyrimidinase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Ferredoxin–nitrite reductase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Fructokinase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Glutamate-5-semialdehyde dehydrogenase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Glutamate 5-kinase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Glutamate carboxypeptidase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Hippurate hydrolase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
HslU–HslV peptidase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
L-seryl-tRNA(Sec) selenium transferase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Maltose-6’-phosphate glucosidase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Methylaspartate ammonia-lyase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Methylglyoxal synthase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Muramoyltetrapeptide carboxypeptidase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Phosphopentomutase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Pyrroline-5-carboxylate reductase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Ribokinase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Selenide, water dikinase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Succinate dehydrogenase (quinone)	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
UDP-glucose 6-dehydrogenase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Urocanate reductase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48719
Dihydroxy-acid dehydratase	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.17078
DNA-3-methyladenine glycosylase I	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.17078
Ketol-acid reductoisomerase (NADP(+))	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.17078
O-acetylhomoserine aminocarboxypropyltransferase	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.17078
UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.17078
2-isopropylmalate synthase	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11963
3-isopropylmalate dehydrogenase	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11963
Aspartate racemase	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11963
Assimilatory sulfite reductase (ferredoxin)	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11963
Assimilatory sulfite reductase (NADPH)	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11963
Homoserine O-succinyltransferase	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11963
NAD(P)H dehydrogenase (quinone)	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11963
Propanal dehydrogenase (CoA-propanoylating)	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11963
Protein-serine/threonine phosphatase	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11963
S-ribosylhomocysteine lyase	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11963
Type II site-specific deoxyribonuclease	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11963
UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11963

plot.dat <- tb.ra %>%
  arrange(p) %>%
  slice_head(n=50)%>%
  mutate(
    description = fct_reorder(description, `Overall Mean`),
    description = factor(description, levels = levels(description), ordered=T)
  ) %>%
  arrange(description) %>%
  mutate(
    id = 1:n(),
    step = ifelse(id%%2 == 0, 1, 0),
    Mean_diff = `Tumor Mean` - `Non-Tumor Mean`,
    Mean_diff_ll = Mean_diff - qt(0.975, df)*SEpooled,
    Mean_diff_ul = Mean_diff + qt(0.975, df)*SEpooled
  ) %>%
  pivot_longer(
    cols=contains("Mean"),
    names_to = "group",
    values_to = "mean"
  )



p1.d <- plot.dat %>%
  filter(group %in% c("Tumor Mean","Non-Tumor Mean")) %>%
  mutate(
    group = ifelse(group == "Tumor Mean", "Tumor", "Non-Tumor"),
    col = ifelse(step == 1, "grey90", "white"),
    h=1, w=Inf
    
  )
p1 <- ggplot()+
  geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_bar(data=p1.d,
             aes(x=mean, y=description,
                 group=group, color=group,
                 fill=group),
             stat="identity",position = "dodge",
             alpha = 1)+
    labs(x="Mean Abundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      plot.margin = unit(c(1,0,1,1), "lines")
    )

p2.d <- plot.dat %>%
  filter(group %in% c("Mean_diff", "Mean_diff_ll", "Mean_diff_ul")) %>%
  pivot_wider(
    names_from = group,
    values_from = mean
  ) %>%
  mutate(
    group = ifelse(Mean_diff > 0, "Tumor", "Non-Tumor"),
    p = sprintf("%.3f", round(p,3)),
    ll = min(Mean_diff_ll)-0.01,
    ul = max(Mean_diff_ul)+0.01
  )
p2<-ggplot(p2.d, aes(x=Mean_diff, y=description))+
    geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_vline(xintercept = 0, linetype="dashed", alpha=0.5)+
    geom_segment(aes(x=Mean_diff_ll, y=description, xend=Mean_diff_ul, yend=description))+
    geom_point(aes(fill=group, color=group))+
    geom_text(aes(label=p, x=unique(ul)+0.1))+
    coord_cartesian(xlim = c(unique(p2.d$ll), unique(p2.d$ul)),
                    clip = 'off') +
    annotate("text", x=unique(p2.d$ul)+0.2,y = 25,
             angle=90,
             label="p-value (uncorrected)")+
    labs(x="Mean Difference in Abundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      axis.title.y = element_blank(),
      axis.text.y = element_blank(),
      axis.line.y = element_blank(),
      axis.ticks.y = element_blank(),
      plot.margin = unit(c(1,4,1,0), "lines")
    )

# plot
p1 + p2 +
  plot_annotation(title="Stratefied EC Data - Fusobacterium nucleatum: First 50 descriptions with lowest p-value (uncorrected)")

Modeling Difference between Tumor and Non-Tumor

For the modeling, we used a generalized linear mixed model (GLMM).

First, we looked at the biserial correlation between the abundance of each description and the tumor status.

tb <- mydata %>%
  group_by(description)%>%
  summarise(
    r = cor(tumor, Abundance)
  ) %>%
  mutate(
    M=mean(r)
  )

ggplot(tb, aes(x=r))+
  geom_density()+
  geom_vline(aes(xintercept = M))+
  labs(x="Biserial Correlation",title="Relationship between description abundance and tumor (tumor vs. non-tumor)")+
  theme(panel.grid = element_blank())

Next, we need the data to be on an interpretable scale. First, let’s use the raw abundance like scale.

p <- ggplot(mydata, aes(x=Abundance))+
  geom_density()
p

mydata <- mydata %>%
  mutate(Abundance.dich=ifelse(Abundance==0, 0, 1))
table(mydata$Abundance.dich)

    0     1 
56739 33637 

Let’s first run models by description so that we can avoid the nesting issue initially. We will come back to this to conduct the final model (it will be more powerful).

DESCRIPTIONS <- unique(mydata$description)
i<-1
dat0 <- mydata %>% filter(description==DESCRIPTIONS[i])

# quasipossion (approximately negative binom) give an approx. answer.
fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
summary(fit0)

Call:
glm(formula = Abundance ~ 1 + tumor, family = quasipoisson(link = "log"), 
    data = dat0)

Deviance Residuals: 
   Min      1Q  Median      3Q     Max  
 -2.42   -2.01   -1.39   -1.08   13.33  

Coefficients:
            Estimate Std. Error t value Pr(>|t|)  
(Intercept)  -0.0378     0.4566   -0.08    0.934  
tumor         1.1152     0.5534    2.02    0.046 *
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for quasipoisson family taken to be 18.666)

    Null deviance: 1230.5  on 157  degrees of freedom
Residual deviance: 1147.8  on 156  degrees of freedom
AIC: NA

Number of Fisher Scoring iterations: 7

Run over all descriptors

results.out <- as.data.frame(matrix(ncol=4, nrow=length(DESCRIPTIONS)))
colnames(results.out) <- c("description", "Est", "SE", "p")
#results.out$description <-DESCRIPTIONS

i <- 1
for(i in 1:length(DESCRIPTIONS)){
#for(i in 1:5){ 
  dat0 <- mydata %>%
    filter(description == DESCRIPTIONS[i])
  fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
  fit.sum <- summary(fit0)
  results.out[i, 1] <- DESCRIPTIONS[i]
  results.out[i, 2:4] <- fit.sum$coefficients[2, c(1,2,4)]
}

results.out$fdr_p <- p.adjust(results.out$p, method="fdr")

kable(results.out, format="html", digits=3) %>%
  kable_styling(full_width = T)%>%
  scroll_box(width="100%", height="600px")

description	Est	SE	p	fdr_p
(2E,6E)-farnesyl diphosphate synthase	1.115	0.553	0.046	0.059
(4S)-4-hydroxy-2-oxoglutarate aldolase	-0.298	0.779	0.702	0.720
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)	1.115	0.553	0.046	0.059
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)	1.115	0.553	0.046	0.059
(FADH(2)-oxidizing)	1.115	0.553	0.046	0.059
(R)-2-methylmalate dehydratase	0.802	0.500	0.111	0.133
(S)-2-hydroxy-acid oxidase	1.359	0.653	0.039	0.059
[Acyl-carrier-protein] S-malonyltransferase	1.115	0.553	0.046	0.059
[Citrate (pro-3S)-lyase] ligase	1.289	0.586	0.029	0.059
[Formate-C-acetyltransferase]-activating enzyme	1.115	0.553	0.046	0.059
[Ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase	-0.298	0.779	0.702	0.720
1-acylglycerol-3-phosphate O-acyltransferase	0.551	0.679	0.419	0.457
1-deoxy-D-xylulose-5-phosphate reductoisomerase	1.115	0.553	0.046	0.059
1-deoxy-D-xylulose-5-phosphate synthase	1.136	0.569	0.048	0.061
1-phosphofructokinase	1.115	0.553	0.046	0.059
1,4-alpha-glucan branching enzyme	1.115	0.553	0.046	0.059
1,4-dihydroxy-2-naphthoate polyprenyltransferase	1.359	0.653	0.039	0.059
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase	1.115	0.553	0.046	0.059
16S rRNA (cytidine(1402)-2’-O)-methyltransferase	1.115	0.553	0.046	0.059
16S rRNA (cytidine(1409)-2’-O)-methyltransferase	1.115	0.553	0.046	0.059
16S rRNA (cytosine(1402)-N(4))-methyltransferase	1.115	0.553	0.046	0.059
16S rRNA (cytosine(967)-C(5))-methyltransferase	1.115	0.553	0.046	0.059
16S rRNA (guanine(1207)-N(2))-methyltransferase	1.115	0.553	0.046	0.059
16S rRNA (guanine(527)-N(7))-methyltransferase	1.115	0.553	0.046	0.059
16S rRNA (uracil(1498)-N(3))-methyltransferase	1.115	0.553	0.046	0.059
16S rRNA pseudouridine(516) synthase	1.115	0.553	0.046	0.059
2’,3’-cyclic-nucleotide 3’-phosphodiesterase	1.352	0.629	0.033	0.059
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase	1.115	0.553	0.046	0.059
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	1.115	0.553	0.046	0.059
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	1.115	0.553	0.046	0.059
2-dehydro-3-deoxy-phosphogluconate aldolase	-0.298	0.779	0.702	0.720
2-dehydro-3-deoxygluconokinase	-0.298	0.779	0.702	0.720
2-deoxy-D-gluconate 3-dehydrogenase	0.551	0.679	0.419	0.457
2-iminoacetate synthase	0.945	0.526	0.074	0.091
2-iminobutanoate/2-iminopropanoate deaminase	1.115	0.553	0.046	0.059
2-isopropylmalate synthase	1.219	0.577	0.036	0.059
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase	1.359	0.653	0.039	0.059
2-phosphosulfolactate phosphatase	0.551	0.679	0.419	0.457
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	-1.604	1.840	0.385	0.455
2.7.11.30 and 2.7.12.1	1.289	0.586	0.029	0.059
23S rRNA (adenine(2503)-C(2))-methyltransferase	1.115	0.553	0.046	0.059
23S rRNA (cytidine(1920)-2’-O)-methyltransferase	1.115	0.553	0.046	0.059
23S rRNA (cytosine(1962)-C(5))-methyltransferase	1.115	0.553	0.046	0.059
23S rRNA (guanine(745)-N(1))-methyltransferase	0.551	0.679	0.419	0.457
23S rRNA (guanosine(2251)-2’-O)-methyltransferase	1.115	0.553	0.046	0.059
23S rRNA (pseudouridine(1915)-N(3))-methyltransferase	1.115	0.553	0.046	0.059
23S rRNA (uracil(1939)-C(5))-methyltransferase	1.115	0.553	0.046	0.059
23S rRNA pseudouridine(1911/1915/1917) synthase	1.115	0.553	0.046	0.059
23S rRNA pseudouridine(2605) synthase	1.115	0.553	0.046	0.059
23S rRNA pseudouridine(955/2504/2580) synthase	1.115	0.553	0.046	0.059
3’(2’),5’-bisphosphate nucleotidase	1.115	0.553	0.046	0.059
3-aminobutyryl-CoA ammonia-lyase	1.115	0.553	0.046	0.059
3-dehydroquinate dehydratase	1.115	0.553	0.046	0.059
3-deoxy-7-phosphoheptulonate synthase	1.115	0.553	0.046	0.059
3-deoxy-8-phosphooctulonate synthase	1.115	0.553	0.046	0.059
3-deoxy-manno-octulosonate-8-phosphatase	1.115	0.553	0.046	0.059
3-deoxy-manno-octulosonate cytidylyltransferase	1.115	0.553	0.046	0.059
3-hydroxyacyl-[acyl-carrier-protein] dehydratase	1.115	0.553	0.046	0.059
3-hydroxybutyryl-CoA dehydratase	0.551	0.679	0.419	0.457
3-hydroxybutyryl-CoA dehydrogenase	1.115	0.553	0.046	0.059
3-isopropylmalate dehydratase	0.802	0.500	0.111	0.133
3-isopropylmalate dehydrogenase	1.219	0.577	0.036	0.059
3-oxoacyl-[acyl-carrier-protein] reductase	1.115	0.553	0.046	0.059
3-phosphoshikimate 1-carboxyvinyltransferase	1.115	0.553	0.046	0.059
3,4-dihydroxy-2-butanone-4-phosphate synthase	1.115	0.553	0.046	0.059
4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol kinase	1.115	0.553	0.046	0.059
4-alpha-glucanotransferase	1.115	0.553	0.046	0.059
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	1.115	0.553	0.046	0.059
4-hydroxy-tetrahydrodipicolinate reductase	0.087	0.625	0.890	0.890
4-hydroxy-tetrahydrodipicolinate synthase	1.072	0.542	0.050	0.063
4-hydroxybutanoyl-CoA dehydratase	-1.604	1.840	0.385	0.455
4-hydroxythreonine-4-phosphate dehydrogenase	-0.215	0.897	0.811	0.825
4-nitrophenylphosphatase	1.352	0.629	0.033	0.059
5’ to 3’ exodeoxyribonuclease (nucleoside 3’-phosphate-forming)	1.292	0.606	0.034	0.059
5-(carboxyamino)imidazole ribonucleotide mutase	1.115	0.553	0.046	0.059
5-amino-6-(5-phosphoribosylamino)uracil reductase	1.115	0.553	0.046	0.059
5-dehydro-4-deoxy-D-glucuronate isomerase	0.551	0.679	0.419	0.457
5-formyltetrahydrofolate cyclo-ligase	1.115	0.553	0.046	0.059
6-carboxytetrahydropterin synthase	-0.298	0.779	0.702	0.720
6-phospho-beta-glucosidase	0.551	0.679	0.419	0.457
6-phosphofructokinase	1.115	0.553	0.046	0.059
6-pyruvoyltetrahydropterin synthase	-0.298	0.779	0.702	0.720
6,7-dimethyl-8-ribityllumazine synthase	1.115	0.553	0.046	0.059
7-carboxy-7-deazaguanine synthase	0.551	0.679	0.419	0.457
7-cyano-7-deazaguanine synthase	0.551	0.679	0.419	0.457
8-amino-7-oxononanoate synthase	1.115	0.553	0.046	0.059
8-oxo-dGTP diphosphatase	1.223	0.582	0.037	0.059
Acetate CoA-transferase	1.223	0.591	0.040	0.059
Acetate kinase	1.115	0.553	0.046	0.059
Acetolactate synthase	1.235	0.541	0.024	0.059
Acetyl-CoA C-acetyltransferase	1.115	0.553	0.046	0.059
Acetyl-CoA carboxylase	1.024	0.536	0.058	0.072
acetylglucosaminyltransferase	1.115	0.553	0.046	0.059
Acyl-[acyl-carrier-protein]–UDP-N-acetylglucosamine O-acyltransferase	1.115	0.553	0.046	0.059
Acylaminoacyl-peptidase	1.115	0.553	0.046	0.059
Adenine deaminase	0.551	0.679	0.419	0.457
Adenine phosphoribosyltransferase	1.223	0.582	0.037	0.059
Adenosylcobalamin/alpha-ribazole phosphatase	1.115	0.553	0.046	0.059
Adenosylcobinamide-GDP ribazoletransferase	1.115	0.553	0.046	0.059
Adenosylcobinamide-phosphate guanylyltransferase	1.115	0.553	0.046	0.059
Adenosylcobinamide-phosphate synthase	1.115	0.553	0.046	0.059
Adenosylcobinamide kinase	1.115	0.553	0.046	0.059
Adenosylcobyric acid synthase (glutamine-hydrolyzing)	1.115	0.553	0.046	0.059
Adenosylhomocysteine nucleosidase	1.115	0.553	0.046	0.059
Adenosylmethionine–8-amino-7-oxononanoate transaminase	1.115	0.553	0.046	0.059
Adenylate kinase	1.115	0.553	0.046	0.059
Adenylosuccinate lyase	1.115	0.553	0.046	0.059
Adenylosuccinate synthase	1.115	0.553	0.046	0.059
ADP-glyceromanno-heptose 6-epimerase	1.115	0.553	0.046	0.059
ADP-ribose diphosphatase	1.115	0.553	0.046	0.059
Alanine–tRNA ligase	1.115	0.553	0.046	0.059
Alanine racemase	1.115	0.553	0.046	0.059
Alcohol dehydrogenase	-1.604	1.840	0.385	0.455
Aldose 1-epimerase	1.115	0.553	0.046	0.059
Altronate dehydratase	0.551	0.679	0.419	0.457
Amidophosphoribosyltransferase	1.115	0.553	0.046	0.059
Aminoacyl-tRNA hydrolase	1.115	0.553	0.046	0.059
Aminodeoxychorismate lyase	1.289	0.586	0.029	0.059
Aminodeoxychorismate synthase	1.319	0.606	0.031	0.059
Arabinose-5-phosphate isomerase	1.115	0.553	0.046	0.059
Arginine–tRNA ligase	1.115	0.553	0.046	0.059
Argininosuccinate lyase	-0.298	0.779	0.702	0.720
Argininosuccinate synthase	-0.298	0.779	0.702	0.720
Arogenate dehydratase	-1.604	1.840	0.385	0.455
Aromatic-amino-acid transaminase	1.115	0.553	0.046	0.059
Arsenate reductase (glutaredoxin)	1.119	0.539	0.040	0.059
Arsenite-transporting ATPase	1.359	0.653	0.039	0.059
Asparaginase	1.115	0.553	0.046	0.059
Asparagine–tRNA ligase	1.115	0.553	0.046	0.059
Asparaginyl-tRNA synthase (glutamine-hydrolyzing)	1.115	0.553	0.046	0.059
Aspartate–ammonia ligase	1.115	0.553	0.046	0.059
Aspartate–tRNA ligase	1.115	0.553	0.046	0.059
Aspartate-semialdehyde dehydrogenase	0.087	0.625	0.890	0.890
Aspartate ammonia-lyase	-0.298	0.779	0.702	0.720
Aspartate carbamoyltransferase	1.115	0.553	0.046	0.059
Aspartate kinase	0.087	0.625	0.890	0.890
Aspartate racemase	1.219	0.577	0.036	0.059
Aspartate transaminase	1.115	0.553	0.046	0.059
Aspartyl aminopeptidase	1.158	0.588	0.051	0.064
Assimilatory sulfite reductase (ferredoxin)	1.219	0.577	0.036	0.059
Assimilatory sulfite reductase (NADPH)	1.219	0.577	0.036	0.059
Beta-fructofuranosidase	0.551	0.679	0.419	0.457
Beta-ketoacyl-[acyl-carrier-protein] synthase II	1.115	0.553	0.046	0.059
Beta-ketoacyl-[acyl-carrier-protein] synthase III	1.223	0.582	0.037	0.059
Beta-lactamase	1.289	0.586	0.029	0.059
Beta-lysine 5,6-aminomutase	1.115	0.553	0.046	0.059
Biotin–[acetyl-CoA-carboxylase] ligase	1.115	0.553	0.046	0.059
Biotin carboxylase	-0.298	0.779	0.702	0.720
Biotin synthase	0.945	0.526	0.074	0.091
Branched-chain-amino-acid transaminase	0.087	0.625	0.890	0.890
Butyrate–acetoacetate CoA-transferase	1.223	0.591	0.040	0.059
C-terminal processing peptidase	1.115	0.553	0.046	0.059
Cadmium-exporting ATPase	1.115	0.553	0.046	0.059
Caffeoyl-CoA O-methyltransferase	1.115	0.553	0.046	0.059
Calcium-transporting ATPase	1.115	0.553	0.046	0.059
Carbamoyl-phosphate synthase (glutamine-hydrolyzing)	1.115	0.553	0.046	0.059
Carbon-monoxide dehydrogenase (acceptor)	0.551	0.679	0.419	0.457
Carbonate dehydratase	0.551	0.679	0.419	0.457
Carboxypeptidase Taq	1.115	0.553	0.046	0.059
CCA tRNA nucleotidyltransferase	1.115	0.553	0.046	0.059
CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase	1.136	0.569	0.048	0.061
CDP-diacylglycerol–serine O-phosphatidyltransferase	1.115	0.553	0.046	0.059
Ceramide glucosyltransferase	1.352	0.629	0.033	0.059
Chorismate mutase	0.922	0.508	0.071	0.088
Chorismate synthase	1.115	0.553	0.046	0.059
Citrate CoA-transferase	1.115	0.553	0.046	0.059
Citrate lyase holo-[acyl-carrier protein] synthase	1.289	0.586	0.029	0.059
Citryl-CoA lyase	1.115	0.553	0.046	0.059
CoB–CoM heterodisulfide reductase	0.551	0.679	0.419	0.457
Cob(I)yrinic acid a,c-diamide adenosyltransferase	1.244	0.577	0.032	0.059
Cobalt-factor II C(20)-methyltransferase	1.115	0.553	0.046	0.059
Cobalt-precorrin-4 methyltransferase	1.115	0.553	0.046	0.059
Cobalt-precorrin-5B (C(1))-methyltransferase	1.115	0.553	0.046	0.059
Cobalt-precorrin-6A reductase	1.115	0.553	0.046	0.059
Cobalt-precorrin-6B (C(15))-methyltransferase (decarboxylating)	1.115	0.553	0.046	0.059
Cobalt-precorrin-7 (C(5))-methyltransferase	1.115	0.553	0.046	0.059
Cobalt-precorrin-8 methylmutase	1.115	0.553	0.046	0.059
Cobalt-precorrin 5A hydrolase	1.115	0.553	0.046	0.059
Cobyrinate a,c-diamide synthase (glutamine-hydrolyzing)	1.115	0.553	0.046	0.059
Coproporphyrinogen dehydrogenase	1.053	0.541	0.053	0.067
Crossover junction endodeoxyribonuclease	1.119	0.539	0.040	0.059
CTP synthase (glutamine hydrolyzing)	0.551	0.679	0.419	0.457
Cu(+) exporting ATPase	1.115	0.553	0.046	0.059
Cyclic pyranopterin phosphate synthase	0.551	0.679	0.419	0.457
Cystathionine beta-lyase	1.129	0.564	0.047	0.060
Cystathionine gamma-synthase	1.355	0.641	0.036	0.059
Cysteine–tRNA ligase	1.263	0.595	0.035	0.059
Cysteine desulfurase	1.119	0.539	0.040	0.059
Cysteine synthase	1.317	0.596	0.029	0.059
Cytidine deaminase	-0.298	0.779	0.702	0.720
D-alanine–D-alanine ligase	1.115	0.553	0.046	0.059
D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase	-0.298	0.779	0.702	0.720
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase	-0.298	0.779	0.702	0.720
D-lactate dehydrogenase	1.115	0.553	0.046	0.059
D-ornithine 4,5-aminomutase	1.219	0.577	0.036	0.059
D-ribose pyranase	0.551	0.679	0.419	0.457
D-sedoheptulose 7-phosphate isomerase	1.115	0.553	0.046	0.059
D-serine ammonia-lyase	1.359	0.653	0.039	0.059
dCMP deaminase	1.115	0.553	0.046	0.059
Demethylmenaquinone methyltransferase	1.359	0.653	0.039	0.059
Deoxyribonuclease IV	0.551	0.679	0.419	0.457
Deoxyribose-phosphate aldolase	-0.298	0.779	0.702	0.720
Dephospho-CoA kinase	1.115	0.553	0.046	0.059
Dethiobiotin synthase	1.115	0.553	0.046	0.059
Diacylglycerol kinase (ATP)	-0.298	0.779	0.702	0.720
Diadenylate cyclase	1.115	0.553	0.046	0.059
Diamine N-acetyltransferase	1.359	0.653	0.039	0.059
Diaminohydroxyphosphoribosylaminopyrimidine deaminase	1.115	0.553	0.046	0.059
Diaminopimelate decarboxylase	0.551	0.679	0.419	0.457
Diaminopimelate epimerase	-0.298	0.779	0.702	0.720
Diaminopropionate ammonia-lyase	-0.215	0.897	0.811	0.825
Dihydrofolate reductase	1.115	0.553	0.046	0.059
Dihydrofolate synthase	1.115	0.553	0.046	0.059
Dihydrolipoyl dehydrogenase	-1.604	1.840	0.385	0.455
Dihydroneopterin aldolase	1.115	0.553	0.046	0.059
Dihydroorotase	1.115	0.553	0.046	0.059
Dihydroorotate dehydrogenase (NAD(+))	1.115	0.553	0.046	0.059
Dihydropteroate synthase	1.115	0.553	0.046	0.059
Dihydropyrimidinase	0.551	0.679	0.419	0.457
Dihydroxy-acid dehydratase	0.802	0.500	0.111	0.133
Dimethylallyltranstransferase	1.115	0.553	0.046	0.059
Dipeptidase E	1.352	0.629	0.033	0.059
diphosphate specific)	1.115	0.553	0.046	0.059
DNA-(apurinic or apyrimidinic site) lyase	1.119	0.539	0.040	0.059
DNA-3-methyladenine glycosylase I	0.802	0.500	0.111	0.133
DNA-directed DNA polymerase	1.094	0.547	0.047	0.060
DNA-directed RNA polymerase	1.115	0.553	0.046	0.059
DNA (cytosine-5-)-methyltransferase	-0.215	0.897	0.811	0.825
DNA helicase	1.115	0.553	0.046	0.059
DNA ligase (NAD(+))	1.115	0.553	0.046	0.059
DNA topoisomerase	1.119	0.539	0.040	0.059
DNA topoisomerase (ATP-hydrolyzing)	1.115	0.553	0.046	0.059
Dolichyl-phosphate beta-D-mannosyltransferase	1.352	0.629	0.033	0.059
dTDP-4-dehydrorhamnose 3,5-epimerase	1.223	0.582	0.037	0.059
dTDP-4-dehydrorhamnose reductase	1.078	0.528	0.043	0.059
dTDP-glucose 4,6-dehydratase	1.115	0.553	0.046	0.059
dTMP kinase	1.115	0.553	0.046	0.059
dUTP diphosphatase	1.115	0.553	0.046	0.059
Endopeptidase Clp	1.115	0.553	0.046	0.059
Endopeptidase La	1.223	0.591	0.040	0.059
Enoyl-[acyl-carrier-protein] reductase (NADH)	1.115	0.553	0.046	0.059
Enoyl-CoA hydratase	1.115	0.553	0.046	0.059
Ethanolamine ammonia-lyase	1.352	0.629	0.033	0.059
Exodeoxyribonuclease III	1.115	0.553	0.046	0.059
Exodeoxyribonuclease VII	1.185	0.571	0.040	0.059
Exopolyphosphatase	1.115	0.553	0.046	0.059
FAD synthetase	1.115	0.553	0.046	0.059
Fe(3+)-transporting ATPase	1.198	0.565	0.036	0.059
Ferredoxin–nitrite reductase	0.551	0.679	0.419	0.457
Formate–tetrahydrofolate ligase	1.115	0.553	0.046	0.059
Formate C-acetyltransferase	1.115	0.553	0.046	0.059
Formimidoylglutamase	1.115	0.553	0.046	0.059
Formimidoyltetrahydrofolate cyclodeaminase	1.355	0.641	0.036	0.059
Formylmethanofuran dehydrogenase	1.359	0.653	0.039	0.059
Fructokinase	0.551	0.679	0.419	0.457
Fructose-bisphosphatase	1.115	0.553	0.046	0.059
Fructose-bisphosphate aldolase	1.078	0.528	0.043	0.059
Fumarate hydratase	-0.298	0.779	0.702	0.720
Fumarate reductase (quinol)	1.235	0.555	0.027	0.059
Galactokinase	1.115	0.553	0.046	0.059
Gamma-glutamyltransferase	1.359	0.653	0.039	0.059
Geranylgeranyl diphosphate synthase	1.115	0.553	0.046	0.059
Glucokinase	1.078	0.528	0.043	0.059
Gluconate 5-dehydrogenase	1.359	0.653	0.039	0.059
Glucosamine-1-phosphate N-acetyltransferase	1.115	0.553	0.046	0.059
Glucosamine-6-phosphate deaminase	1.115	0.553	0.046	0.059
Glucose-1-phosphate adenylyltransferase	1.115	0.553	0.046	0.059
Glucose-1-phosphate thymidylyltransferase	-0.298	0.779	0.702	0.720
Glucose-6-phosphate isomerase	1.115	0.553	0.046	0.059
Glutaconate CoA-transferase	1.115	0.553	0.046	0.059
Glutaconyl-CoA decarboxylase	1.115	0.553	0.046	0.059
Glutamate–ammonia ligase	0.087	0.625	0.890	0.890
Glutamate–tRNA ligase	1.115	0.553	0.046	0.059
Glutamate-1-semialdehyde 2,1-aminomutase	1.115	0.553	0.046	0.059
Glutamate-5-semialdehyde dehydrogenase	0.551	0.679	0.419	0.457
Glutamate 5-kinase	0.551	0.679	0.419	0.457
Glutamate carboxypeptidase	0.551	0.679	0.419	0.457
Glutamate dehydrogenase	1.115	0.553	0.046	0.059
Glutamate formimidoyltransferase	1.355	0.641	0.036	0.059
Glutamate racemase	1.083	0.516	0.037	0.059
Glutamate synthase (NADH)	-0.298	0.779	0.702	0.720
Glutamate synthase (NADPH)	-0.298	0.779	0.702	0.720
Glutaminase	1.115	0.553	0.046	0.059
Glutamine–fructose-6-phosphate transaminase (isomerizing)	1.115	0.553	0.046	0.059
Glutaminyl-tRNA synthase (glutamine-hydrolyzing)	1.115	0.553	0.046	0.059
Glutamyl-tRNA reductase	1.115	0.553	0.046	0.059
Glutathione hydrolase	1.359	0.653	0.039	0.059
Glutathione peroxidase	1.115	0.553	0.046	0.059
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	1.115	0.553	0.046	0.059
Glycerate 3-kinase	-0.298	0.779	0.702	0.720
Glycerate dehydrogenase	1.289	0.586	0.029	0.059
Glycerol-3-phosphate 1-O-acyltransferase	1.115	0.553	0.046	0.059
Glycerol-3-phosphate cytidylyltransferase	1.115	0.553	0.046	0.059
Glycerol-3-phosphate dehydrogenase	1.115	0.553	0.046	0.059
Glycerol-3-phosphate dehydrogenase (NAD(P)(+))	1.115	0.553	0.046	0.059
Glycerol kinase	1.115	0.553	0.046	0.059
Glycerophosphodiester phosphodiesterase	1.223	0.582	0.037	0.059
Glycine–tRNA ligase	1.115	0.553	0.046	0.059
Glycine hydroxymethyltransferase	-0.298	0.779	0.702	0.720
Glycogen phosphorylase	1.115	0.553	0.046	0.059
GMP synthase (glutamine-hydrolyzing)	1.115	0.553	0.046	0.059
GTP cyclohydrolase I	1.115	0.553	0.046	0.059
GTP cyclohydrolase II	1.115	0.553	0.046	0.059
GTP diphosphokinase	1.115	0.553	0.046	0.059
Guanosine-3’,5’-bis(diphosphate) 3’-diphosphatase	1.115	0.553	0.046	0.059
Guanosine-5’-triphosphate,3’-diphosphate diphosphatase	1.115	0.553	0.046	0.059
Guanylate kinase	1.115	0.553	0.046	0.059
H(+)-transporting two-sector ATPase	1.129	0.564	0.047	0.060
Heptaprenyl diphosphate synthase	1.223	0.591	0.040	0.059
Hippurate hydrolase	0.551	0.679	0.419	0.457
Histidine–tRNA ligase	1.115	0.553	0.046	0.059
Histidine ammonia-lyase	1.223	0.591	0.040	0.059
Histidine kinase	0.938	0.511	0.068	0.084
Histidinol-phosphatase	1.115	0.553	0.046	0.059
Holo-[acyl-carrier-protein] synthase	1.115	0.553	0.046	0.059
Homoserine dehydrogenase	0.087	0.625	0.890	0.890
Homoserine kinase	1.119	0.539	0.040	0.059
Homoserine O-succinyltransferase	1.219	0.577	0.036	0.059
HslU–HslV peptidase	0.551	0.679	0.419	0.457
Hydrogen dehydrogenase (NADP(+))	0.551	0.679	0.419	0.457
Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)	1.115	0.553	0.046	0.059
Hydroxyacylglutathione hydrolase	1.115	0.553	0.046	0.059
Hydroxylamine reductase	1.115	0.553	0.046	0.059
Hydroxymethylbilane synthase	1.115	0.553	0.046	0.059
Hydroxymethylglutaryl-CoA lyase	1.359	0.653	0.039	0.059
Hydroxymethylpyrimidine kinase	1.115	0.553	0.046	0.059
Hypoxanthine phosphoribosyltransferase	1.115	0.553	0.046	0.059
Imidazolonepropionase	1.223	0.591	0.040	0.059
IMP cyclohydrolase	1.115	0.553	0.046	0.059
IMP dehydrogenase	1.115	0.553	0.046	0.059
Inorganic diphosphatase	1.184	0.577	0.042	0.059
Iron-chelate-transporting ATPase	1.206	0.582	0.040	0.059
Isocitrate dehydrogenase (NAD(+))	1.359	0.653	0.039	0.059
Isoleucine–tRNA ligase	1.115	0.553	0.046	0.059
Kdo(2)-lipid IV(A) lauroyltransferase	1.119	0.539	0.040	0.059
Ketol-acid reductoisomerase (NADP(+))	0.802	0.500	0.111	0.133
L-aspartate oxidase	1.115	0.553	0.046	0.059
L-erythro-3,5-diaminohexanoate dehydrogenase	1.115	0.553	0.046	0.059
L-fuculose-phosphate aldolase	1.155	0.607	0.059	0.073
L-lactate dehydrogenase	1.115	0.553	0.046	0.059
L-rhamnonate dehydratase	1.359	0.653	0.039	0.059
L-serine ammonia-lyase	1.115	0.553	0.046	0.059
L-seryl-tRNA(Sec) selenium transferase	0.551	0.679	0.419	0.457
L-threonine aldolase	1.115	0.553	0.046	0.059
L-threonylcarbamoyladenylate synthase	1.115	0.553	0.046	0.059
Lactaldehyde reductase	1.322	0.616	0.034	0.059
Lactoylglutathione lyase	1.223	0.582	0.037	0.059
Leucine–tRNA ligase	1.115	0.553	0.046	0.059
Leucyl aminopeptidase	1.115	0.553	0.046	0.059
Lipid-A-disaccharide synthase	1.115	0.553	0.046	0.059
Long-chain-fatty-acid–CoA ligase	1.184	0.577	0.042	0.059
Lysine–tRNA ligase	1.115	0.553	0.046	0.059
Lysine 2,3-aminomutase	1.115	0.553	0.046	0.059
Magnesium-importing ATPase	-1.604	1.840	0.385	0.455
Malate dehydrogenase (oxaloacetate-decarboxylating)	-0.298	0.779	0.702	0.720
Malonyl-[acyl-carrier protein] O-methyltransferase	1.115	0.553	0.046	0.059
Maltose-6’-phosphate glucosidase	0.551	0.679	0.419	0.457
Mannose-6-phosphate isomerase	-0.298	0.779	0.702	0.720
Methenyltetrahydrofolate cyclohydrolase	1.115	0.553	0.046	0.059
Methionine–tRNA ligase	1.115	0.553	0.046	0.059
Methionine adenosyltransferase	1.115	0.553	0.046	0.059
Methionine gamma-lyase	1.115	0.553	0.046	0.059
Methionine synthase	1.115	0.553	0.046	0.059
Methionyl-tRNA formyltransferase	1.115	0.553	0.046	0.059
Methionyl aminopeptidase	1.115	0.553	0.046	0.059
Methylaspartate ammonia-lyase	0.551	0.679	0.419	0.457
Methylaspartate mutase	1.198	0.565	0.036	0.059
Methylated-DNA–[protein]-cysteine S-methyltransferase	1.115	0.553	0.046	0.059
Methylenetetrahydrofolate dehydrogenase (NADP(+))	1.115	0.553	0.046	0.059
Methylenetetrahydrofolate reductase (NAD(P)H)	0.087	0.625	0.890	0.890
Methylglyoxal synthase	0.551	0.679	0.419	0.457
Monosaccharide-transporting ATPase	1.096	0.540	0.044	0.059
Muramoyltetrapeptide carboxypeptidase	0.551	0.679	0.419	0.457
N-acetylglucosamine-6-phosphate deacetylase	1.115	0.553	0.046	0.059
N-acetylmuramoyl-L-alanine amidase	1.101	0.527	0.038	0.059
N-acetylneuraminate lyase	1.115	0.553	0.046	0.059
N-acyl-D-amino-acid deacylase	0.087	0.625	0.890	0.890
N-acylglucosamine-6-phosphate 2-epimerase	1.115	0.553	0.046	0.059
N(6)-L-threonylcarbamoyladenine synthase	1.115	0.553	0.046	0.059
NAD(+) kinase	1.115	0.553	0.046	0.059
NAD(+) synthase	1.115	0.553	0.046	0.059
NAD(P)H dehydrogenase (quinone)	1.219	0.577	0.036	0.059
NADH:ubiquinone reductase (H(+)-translocating)	-0.115	0.694	0.868	0.882
Nickel-transporting ATPase	1.352	0.629	0.033	0.059
Nicotinamide-nucleotide amidase	1.115	0.553	0.046	0.059
Nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase	1.115	0.553	0.046	0.059
Nicotinate-nucleotide adenylyltransferase	1.115	0.553	0.046	0.059
Nicotinate-nucleotide diphosphorylase (carboxylating)	1.115	0.553	0.046	0.059
Nicotinate phosphoribosyltransferase	1.115	0.553	0.046	0.059
Nitrogenase	1.352	0.629	0.033	0.059
Nitronate monooxygenase	1.352	0.629	0.033	0.059
Non-specific serine/threonine protein kinase	1.127	0.569	0.049	0.062
O-acetylhomoserine aminocarboxypropyltransferase	0.802	0.500	0.111	0.133
Oligonucleotidase	1.115	0.553	0.046	0.059
Ornithine decarboxylase	1.289	0.586	0.029	0.059
Orotate phosphoribosyltransferase	1.115	0.553	0.046	0.059
Orotidine-5’-phosphate decarboxylase	1.078	0.528	0.043	0.059
Oxaloacetate decarboxylase	1.115	0.553	0.046	0.059
Pantetheine-phosphate adenylyltransferase	1.115	0.553	0.046	0.059
Pantothenate kinase	1.115	0.553	0.046	0.059
Peptide-methionine (R)-S-oxide reductase	1.223	0.582	0.037	0.059
Peptide-methionine (S)-S-oxide reductase	1.198	0.565	0.036	0.059
Peptide chain release factor N(5)-glutamine methyltransferase	1.115	0.553	0.046	0.059
Peptide deformylase	1.115	0.553	0.046	0.059
Peptidylprolyl isomerase	1.190	0.568	0.038	0.059
Peroxiredoxin	1.115	0.553	0.046	0.059
Phenylalanine–tRNA ligase	1.115	0.553	0.046	0.059
Phosphate-transporting ATPase	-0.298	0.779	0.702	0.720
Phosphate acetyltransferase	1.119	0.539	0.040	0.059
Phosphatidate cytidylyltransferase	1.136	0.569	0.048	0.061
Phosphatidylglycerophosphatase	1.115	0.553	0.046	0.059
Phosphatidylserine decarboxylase	1.115	0.553	0.046	0.059
Phospho-N-acetylmuramoyl-pentapeptide-transferase	1.115	0.553	0.046	0.059
Phosphoenolpyruvate–protein phosphotransferase	1.078	0.528	0.043	0.059
Phosphoenolpyruvate carboxykinase (ATP)	1.352	0.629	0.033	0.059
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)	1.115	0.553	0.046	0.059
Phosphoglucosamine mutase	1.115	0.553	0.046	0.059
Phosphoglycerate dehydrogenase	1.158	0.588	0.051	0.064
Phosphoglycerate kinase	1.115	0.553	0.046	0.059
Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)	1.250	0.613	0.043	0.059
Phosphoglycerate mutase (2,3-diphosphoglycerate-independent)	0.945	0.526	0.074	0.091
Phosphomethylpyrimidine kinase	1.115	0.553	0.046	0.059
Phosphomethylpyrimidine synthase	1.115	0.553	0.046	0.059
Phosphonate-transporting ATPase	1.352	0.629	0.033	0.059
Phosphopantothenate–cysteine ligase	1.115	0.553	0.046	0.059
Phosphopantothenoylcysteine decarboxylase	1.115	0.553	0.046	0.059
Phosphopentomutase	0.551	0.679	0.419	0.457
Phosphopyruvate hydratase	1.115	0.553	0.046	0.059
Phosphoribosylamine–glycine ligase	1.115	0.553	0.046	0.059
Phosphoribosylaminoimidazolecarboxamide formyltransferase	1.115	0.553	0.046	0.059
Phosphoribosylaminoimidazolesuccinocarboxamide synthase	1.115	0.553	0.046	0.059
Phosphoribosylformylglycinamidine cyclo-ligase	1.115	0.553	0.046	0.059
Phosphoribosylformylglycinamidine synthase	1.115	0.553	0.046	0.059
Phosphoribosylglycinamide formyltransferase	1.223	0.591	0.040	0.059
Phosphoserine phosphatase	1.115	0.553	0.046	0.059
Pimeloyl-[acyl-carrier protein] methyl ester esterase	1.115	0.553	0.046	0.059
Polar-amino-acid-transporting ATPase	0.954	0.514	0.065	0.081
Polyamine-transporting ATPase	1.115	0.553	0.046	0.059
Polyribonucleotide nucleotidyltransferase	1.115	0.553	0.046	0.059
Porphobilinogen synthase	1.115	0.553	0.046	0.059
Precorrin-2 C(20)-methyltransferase	1.115	0.553	0.046	0.059
Precorrin-2 dehydrogenase	1.115	0.553	0.046	0.059
Precorrin-3B C(17)-methyltransferase	1.115	0.553	0.046	0.059
Precorrin-4 C(11)-methyltransferase	1.115	0.553	0.046	0.059
Precorrin-6A reductase	1.115	0.553	0.046	0.059
Precorrin-8X methylmutase	1.115	0.553	0.046	0.059
Prephenate dehydratase	-0.298	0.779	0.702	0.720
Prepilin peptidase	1.115	0.553	0.046	0.059
Proline–tRNA ligase	1.115	0.553	0.046	0.059
Prolyl aminopeptidase	1.352	0.629	0.033	0.059
Propanal dehydrogenase (CoA-propanoylating)	1.219	0.577	0.036	0.059
Propanediol dehydratase	1.219	0.577	0.036	0.059
Propionate CoA-transferase	-0.298	0.779	0.702	0.720
Protein-N(pi)-phosphohistidine–sugar phosphotransferase	0.946	0.535	0.079	0.097
Protein-serine/threonine phosphatase	1.219	0.577	0.036	0.059
Purine-nucleoside phosphorylase	1.115	0.553	0.046	0.059
Pyridoxal 5’-phosphate synthase (glutamine hydrolyzing)	1.078	0.528	0.043	0.059
Pyridoxal kinase	-0.298	0.779	0.702	0.720
Pyroglutamyl-peptidase I	1.115	0.553	0.046	0.059
Pyrroline-5-carboxylate reductase	0.551	0.679	0.419	0.457
Pyruvate kinase	1.115	0.553	0.046	0.059
Pyruvate synthase	1.264	0.609	0.039	0.059
Pyruvate, phosphate dikinase	1.115	0.553	0.046	0.059
Quinolinate synthase	1.115	0.553	0.046	0.059
Repressor LexA	1.286	0.569	0.025	0.059
Riboflavin kinase	1.115	0.553	0.046	0.059
Riboflavin synthase	1.115	0.553	0.046	0.059
Ribokinase	0.551	0.679	0.419	0.457
Ribonuclease H	0.954	0.514	0.065	0.081
Ribonuclease III	1.115	0.553	0.046	0.059
Ribonuclease M5	1.115	0.553	0.046	0.059
Ribonuclease P	1.115	0.553	0.046	0.059
Ribonucleoside-diphosphate reductase	1.115	0.553	0.046	0.059
Ribonucleoside-triphosphate reductase	1.115	0.553	0.046	0.059
Ribose-5-phosphate isomerase	1.115	0.553	0.046	0.059
Ribose-phosphate diphosphokinase	1.115	0.553	0.046	0.059
Ribosomal-protein-alanine N-acetyltransferase	1.264	0.602	0.037	0.059
Ribulose-phosphate 3-epimerase	1.115	0.553	0.046	0.059
RNA helicase	1.115	0.553	0.046	0.059
S-adenosylmethionine:tRNA ribosyltransferase-isomerase	1.115	0.553	0.046	0.059
S-methyl-5-thioribose-1-phosphate isomerase	1.359	0.653	0.039	0.059
S-methyl-5-thioribose kinase	1.359	0.653	0.039	0.059
S-ribosylhomocysteine lyase	1.219	0.577	0.036	0.059
Selenide, water dikinase	0.551	0.679	0.419	0.457
Serine–tRNA ligase	1.115	0.553	0.046	0.059
Serine-type D-Ala-D-Ala carboxypeptidase	1.115	0.553	0.046	0.059
Serine O-acetyltransferase	-0.215	0.897	0.811	0.825
Shikimate dehydrogenase	1.286	0.613	0.038	0.059
Shikimate kinase	1.115	0.553	0.046	0.059
Short-chain acyl-CoA dehydrogenase	1.184	0.577	0.042	0.059
Signal peptidase I	1.115	0.553	0.046	0.059
Signal peptidase II	1.115	0.553	0.046	0.059
Sirohydrochlorin cobaltochelatase	1.115	0.553	0.046	0.059
Sirohydrochlorin ferrochelatase	1.115	0.553	0.046	0.059
Site-specific DNA-methyltransferase (adenine-specific)	1.093	0.527	0.040	0.059
Spore photoproduct lyase	1.115	0.553	0.046	0.059
Starch synthase	1.115	0.553	0.046	0.059
Succinate dehydrogenase (quinone)	0.551	0.679	0.419	0.457
Succinyl-diaminopimelate desuccinylase	1.115	0.553	0.046	0.059
Sulfoacetaldehyde dehydrogenase (acylating)	1.359	0.653	0.039	0.059
Sulfur carrier protein ThiS adenylyltransferase	1.115	0.553	0.046	0.059
Superoxide reductase	-0.298	0.779	0.702	0.720
Tetraacyldisaccharide 4’-kinase	1.115	0.553	0.046	0.059
Tetrahydrodipicolinate N-acetyltransferase	-0.298	0.779	0.702	0.720
Tetrahydrofolate synthase	1.115	0.553	0.046	0.059
Thiamine-phosphate diphosphorylase	1.223	0.582	0.037	0.059
Thiamine diphosphokinase	1.115	0.553	0.046	0.059
Thiazole synthase	1.115	0.553	0.046	0.059
Thioredoxin-disulfide reductase	1.115	0.553	0.046	0.059
Threonine–tRNA ligase	1.115	0.553	0.046	0.059
Threonine-phosphate decarboxylase	1.115	0.553	0.046	0.059
Threonine ammonia-lyase	1.119	0.539	0.040	0.059
Threonine synthase	0.087	0.625	0.890	0.890
Thymidylate synthase	1.115	0.553	0.046	0.059
Transketolase	1.115	0.553	0.046	0.059
Triacylglycerol lipase	1.352	0.629	0.033	0.059
Triose-phosphate isomerase	1.115	0.553	0.046	0.059
Tripeptide aminopeptidase	1.115	0.553	0.046	0.059
Triphosphoribosyl-dephospho-CoA synthase	1.289	0.586	0.029	0.059
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase	1.115	0.553	0.046	0.059
tRNA-guanine(34) transglycosylase	1.115	0.553	0.046	0.059
tRNA (cytidine(34)-2’-O)-methyltransferase	1.115	0.553	0.046	0.059
tRNA (guanine(37)-N(1))-methyltransferase	1.115	0.553	0.046	0.059
tRNA (guanine(46)-N(7))-methyltransferase	1.078	0.528	0.043	0.059
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase	1.115	0.553	0.046	0.059
tRNA dimethylallyltransferase	1.115	0.553	0.046	0.059
tRNA nucleotidyltransferase	-0.298	0.779	0.702	0.720
tRNA pseudouridine(38-40) synthase	1.115	0.553	0.046	0.059
tRNA pseudouridine(55) synthase	1.115	0.553	0.046	0.059
tRNA(Ile)-lysidine synthetase	1.115	0.553	0.046	0.059
Tryptophan–tRNA ligase	1.115	0.553	0.046	0.059
Tryptophan synthase	1.352	0.629	0.033	0.059
Tryptophanase	1.286	0.569	0.025	0.059
Type I site-specific deoxyribonuclease	1.223	0.578	0.036	0.059
Type II site-specific deoxyribonuclease	1.219	0.577	0.036	0.059
Type III site-specific deoxyribonuclease	0.915	0.466	0.051	0.064
Tyrosine–tRNA ligase	1.115	0.553	0.046	0.059
Tyrosine phenol-lyase	1.158	0.588	0.051	0.064
UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase	1.219	0.577	0.036	0.059
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	1.223	0.591	0.040	0.059
UDP-3-O-acyl-N-acetylglucosamine deacetylase	1.115	0.553	0.046	0.059
UDP-glucose–hexose-1-phosphate uridylyltransferase	1.115	0.553	0.046	0.059
UDP-glucose 4-epimerase	1.115	0.553	0.046	0.059
UDP-glucose 6-dehydrogenase	0.551	0.679	0.419	0.457
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	1.115	0.553	0.046	0.059
UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	0.802	0.500	0.111	0.133
UDP-N-acetylglucosamine diphosphorylase	1.115	0.553	0.046	0.059
UDP-N-acetylglucosamine kinase	1.219	0.577	0.036	0.059
UDP-N-acetylmuramate–L-alanine ligase	1.115	0.553	0.046	0.059
UDP-N-acetylmuramate dehydrogenase	1.115	0.553	0.046	0.059
UDP-N-acetylmuramoyl-L-alanine–D-glutamate ligase	1.115	0.553	0.046	0.059
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase	1.115	0.553	0.046	0.059
UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase	1.078	0.528	0.043	0.059
UMP kinase	1.115	0.553	0.046	0.059
UMP/CMP kinase	1.115	0.553	0.046	0.059
Undecaprenyl-diphosphate phosphatase	1.115	0.553	0.046	0.059
Uracil-DNA glycosylase	1.115	0.553	0.046	0.059
Uracil phosphoribosyltransferase	1.223	0.582	0.037	0.059
Uridine kinase	-0.298	0.779	0.702	0.720
Uridine phosphorylase	-1.604	1.840	0.385	0.455
Urocanate hydratase	1.223	0.591	0.040	0.059
Urocanate reductase	0.551	0.679	0.419	0.457
Uroporphyrinogen-III C-methyltransferase	1.115	0.553	0.046	0.059
Uroporphyrinogen-III synthase	1.115	0.553	0.046	0.059
UTP–glucose-1-phosphate uridylyltransferase	1.115	0.553	0.046	0.059
Valine–tRNA ligase	1.115	0.553	0.046	0.059
Vinylacetyl-CoA Delta-isomerase	-1.604	1.840	0.385	0.455
Xaa-Pro aminopeptidase	1.115	0.553	0.046	0.059
Xaa-Pro dipeptidase	1.115	0.553	0.046	0.059
Xanthine phosphoribosyltransferase	-0.298	0.779	0.702	0.720
XTP/dITP diphosphatase	-0.298	0.779	0.702	0.720
Zinc-exporting ATPase	1.115	0.553	0.046	0.059

# merge with tb.ra for full results table
full.res <- left_join(tb.ra, results.out, by = "description")

write.csv(full.res, "output/picrust_ec_stratefied_fuso_data_results.csv", row.names = F)

Part 2 KO Data

descriptions <- readr::read_tsv("data/PICRUST/ko_pred_metagenome_unstrat_descrip.tsv")[,1:2] %>%
  distinct()

-- Column specification --------------------------------------------------------
cols(
  .default = col_double(),
  `function` = col_character(),
  description = col_character()
)
i Use `spec()` for the full column specifications.

colnames(descriptions) <- c("func", "description")

pi.dat <- readxl::read_xlsx("data/PICRUST-Stratified/KO_fuso.xlsx")
colnames(pi.dat) <- c("func",  colnames(pi.dat)[-c(1)])

# add descriptions to dataframe
pi.dat <- left_join(pi.dat, descriptions, by="func")
pi.dat <- pi.dat[,c(1,161,3:160)]

# aggregate descriptions to get 1 description per row - unique;y defined.
pi.dat <- pi.dat %>%
  group_by(description) %>%
  summarise(across(`X1.S37.Jun172016`:`X99.D01.S37.Jun232016`,.fns = mean))

# make long format
pi.dat <- pi.dat %>%
  pivot_longer(
    cols=`X1.S37.Jun172016`:`X99.D01.S37.Jun232016`,
    names_to = "ID",
    values_to = "Abundance"
  ) %>%
  mutate(
    ID = substr(ID, 2, 99)
  )

d <- as.data.frame(dat.16s)
mydata <- full_join(pi.dat, d)

Joining, by = "ID"

Warning in class(x) <- c(setdiff(subclass, tibble_class), tibble_class): Setting
class(x) to multiple strings ("tbl_df", "tbl", ...); result will no longer be an
S4 object

mydata <- mydata %>%
  mutate(
    ID.n = as.numeric(as.factor(ID)),
    description.n = as.numeric(as.factor(description))
  ) %>%
  group_by(description)%>%
  mutate(avgA = mean(Abundance))

Abundance

# Run on all descriptions
tb.ra1 <- mydata %>%
  group_by(description) %>%
  summarise(ng = n(),
            Overall.M = mean(Abundance),
            Overall.SE = sd(Abundance)/sqrt(ng))
tb.ra2m <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(M = mean(Abundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = M)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2se <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(),SE = sd(Abundance)/sqrt(ng)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = SE)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2var <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(), VAR = var(Abundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = VAR)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2ng <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n()) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = ng)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra <- left_join(tb.ra1, tb.ra2m)

Joining, by = "description"

tb.ra <- cbind(tb.ra, tb.ra2se[,-1])
tb.ra <- cbind(tb.ra, tb.ra2var[,-1])
tb.ra <- cbind(tb.ra, tb.ra2ng[,-1]) 

colnames(tb.ra) <- c("description", "ng", "Overall Mean", "Overall SE", "Non-Tumor Mean", "Tumor Mean", "Non-Tumor SE", "Tumor SE","Non-Tumor Var", "Tumor Var", "Non-Tumor Ng", "Tumor Ng")
tb.ra <- tb.ra %>%
  arrange(desc(`Overall Mean`))
tb.ra <- tb.ra[, c("description", "Overall Mean", "Overall SE","Tumor Mean","Tumor Var", "Tumor SE","Tumor Ng", "Non-Tumor Mean","Non-Tumor Var", "Non-Tumor SE", "Non-Tumor Ng")]

# compute t-test
tb.ra <- tb.ra %>%
  mutate(
    SEpooled = sqrt(`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`),
    t = (`Tumor Mean` - `Non-Tumor Mean`)/(SEpooled),
    df = ((`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`)**2)/(((`Tumor Var`/`Tumor Ng`)**2)/(`Tumor Ng`-1) + ((`Non-Tumor Var`/`Non-Tumor Ng`)**2)/(`Non-Tumor Ng`-1)),
    p = pt(q = abs(t), df=df, lower.tail = F)*2,
    fdr_p = p.adjust(p, method="fdr")
  )
kable(tb.ra, format="html", digits=5, caption="Stratefied KO Data - Fusobacterium nucleatum: Average Abundance of Each Description (sorted in descending order)") %>%
  kable_styling(full_width = T) %>%
  scroll_box(width = "100%", height="600px")

Stratefied KO Data - Fusobacterium nucleatum: Average Abundance of Each Description (sorted in descending order)

description	Overall Mean	Overall SE	Tumor Mean	Tumor Var	Tumor SE	Tumor Ng	Non-Tumor Mean	Non-Tumor Var	Non-Tumor SE	Non-Tumor Ng	SEpooled	t	df	p	fdr_p
K07487; transposase	58.98734	19.24740	104.84615	119296.85096	42.84082	65	26.93548	14374.47405	12.43239	93	44.60830	1.74655	74.864	0.08482	0.11932
K06867; uncharacterized protein	47.18987	15.39792	83.87692	76349.98462	34.27266	65	21.54839	9199.66339	9.94591	93	35.68664	1.74655	74.864	0.08482	0.11932
K06915; uncharacterized protein	35.39241	11.54844	62.90769	42946.86635	25.70449	65	16.16129	5174.81066	7.45943	93	26.76498	1.74655	74.864	0.08482	0.11932
K06926; uncharacterized protein	35.39241	11.54844	62.90769	42946.86635	25.70449	65	16.16129	5174.81066	7.45943	93	26.76498	1.74655	74.864	0.08482	0.11932
K07486; transposase	35.39241	11.54844	62.90769	42946.86635	25.70449	65	16.16129	5174.81066	7.45943	93	26.76498	1.74655	74.864	0.08482	0.11932
arsA, ASNA1, GET3; arsenite/tail-anchored protein-transporting ATPase [EC:3.6.3.16 3.6.3.-]	23.59494	7.69896	41.93846	19087.49615	17.13633	65	10.77419	2299.91585	4.97295	93	17.84332	1.74655	74.864	0.08482	0.11932
ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]	23.59494	7.69896	41.93846	19087.49615	17.13633	65	10.77419	2299.91585	4.97295	93	17.84332	1.74655	74.864	0.08482	0.11932
K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	23.59494	7.69896	41.93846	19087.49615	17.13633	65	10.77419	2299.91585	4.97295	93	17.84332	1.74655	74.864	0.08482	0.11932
ABC.PE.S; peptide/nickel transport system substrate-binding protein	16.08418	4.57245	26.46500	6414.37957	9.93392	65	8.82876	1045.71963	3.35325	93	10.48461	1.68211	78.705	0.09651	0.12226
ytmI; uncharacterized N-acetyltransferase [EC:2.3.1.-]	14.47563	4.40816	25.05462	6172.41406	9.74475	65	7.08172	811.24021	2.95347	93	10.18250	1.76508	75.853	0.08158	0.11932
ABC.PE.A1; peptide/nickel transport system ATP-binding protein	13.04082	3.93175	22.45808	4905.00744	8.68687	65	6.45887	649.49349	2.64269	93	9.07995	1.76204	75.942	0.08209	0.11932
ABC-2.P; ABC-2 type transport system permease protein	12.67089	3.94278	21.23077	4850.71154	8.63865	65	6.68817	729.19518	2.80014	93	9.08114	1.60141	77.560	0.11335	0.13801
nfdA; N-substituted formamide deformylase [EC:3.5.1.91]	12.67089	3.94278	21.23077	4850.71154	8.63865	65	6.68817	729.19518	2.80014	93	9.08114	1.60141	77.560	0.11335	0.13801
fhaB; filamentous hemagglutinin	12.44810	3.88810	22.03121	4825.80494	8.61645	65	5.75023	608.78186	2.55852	93	8.98828	1.81136	75.376	0.07407	0.11932
ABCB-BAC; ATP-binding cassette, subfamily B, bacterial	12.12468	3.51089	20.24269	3836.93476	7.68308	65	6.45081	575.27862	2.48713	93	8.07561	1.70784	77.524	0.09167	0.11932
algI; alginate O-acetyltransferase complex protein AlgI	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
cas5t; CRISPR-associated protein Cas5t	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
cst1, cas8a; CRISPR-associated protein Cst1	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
cst2, cas7; CRISPR-associated protein Cst2	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
dctM; C4-dicarboxylate transporter, DctM subunit	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
dsdA; D-serine dehydratase [EC:4.3.1.18]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
E4.1.3.4, HMGCL, hmgL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
ENDOG; endonuclease G, mitochondrial	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
fixC; electron transfer flavoprotein-quinone oxidoreductase [EC:1.5.5.-]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
fwdE, fmdE; formylmethanofuran dehydrogenase subunit E [EC:1.2.7.12]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
gfrE; glucoselysine-6-phosphate deglycase	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
gfrF; fructoselysine-6-phosphate deglycase	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
glcD; glycolate oxidase [EC:1.1.3.15]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
IDH3; isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
idnO; gluconate 5-dehydrogenase [EC:1.1.1.69]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
K07032; uncharacterized protein	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
K09780; uncharacterized protein	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
K13653; AraC family transcriptional regulator	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
lldG; L-lactate dehydrogenase complex protein LldG	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
LRA3, yfaW; L-rhamnonate dehydratase [EC:4.2.1.90]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
menA; 1,4-dihydroxy-2-naphthoate octaprenyltransferase [EC:2.5.1.74 2.5.1.-]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
metC; cystathionine beta-lyase [EC:4.4.1.8]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
mtnA; methylthioribose-1-phosphate isomerase [EC:5.3.1.23]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
mtnK; 5-methylthioribose kinase [EC:2.7.1.100]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
ppa; inorganic pyrophosphatase [EC:3.6.1.1]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
PTS-Bgl-EIIC, bglF, bglP; PTS system, beta-glucoside-specific IIC component	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
PTS-Gfr-EIIA, gfrA; PTS system, fructoselysine/glucoselysine-specific IIA component [EC:2.7.1.-]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
PTS-Gfr-EIIB, gfrB; PTS system, fructoselysine/glucoselysine-specific IIB component [EC:2.7.1.-]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
PTS-Gfr-EIIC, gfrC; PTS system, fructoselysine/glucoselysine-specific IIC component	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
PTS-Gfr-EIID, gfrD; PTS system, fructoselysine/glucoselysine-specific IID component	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
sauS; sulfoacetaldehyde dehydrogenase [EC:1.2.1.81]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
speG, SAT; diamine N-acetyltransferase [EC:2.3.1.57]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
TC.CITMHS; citrate-Mg2+:H+ or citrate-Ca2+:H+ symporter, CitMHS family	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
wbpO; UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.-]	11.79747	3.84948	20.96923	4771.87404	8.56816	65	5.38710	574.97896	2.48648	93	8.92166	1.74655	74.864	0.08482	0.11932
ABC.FEV.A; iron complex transport system ATP-binding protein [EC:3.6.3.34]	11.59968	3.45917	19.74038	3775.28628	7.62111	65	5.90995	520.52934	2.36582	93	7.97988	1.73316	76.435	0.08710	0.11932
ABC.FEV.P; iron complex transport system permease protein	11.53038	3.45145	19.73231	3778.95574	7.62481	65	5.79785	502.39013	2.32423	93	7.97119	1.74810	75.990	0.08449	0.11932
ABC.PE.P; peptide/nickel transport system permease protein	11.37500	3.43884	19.55385	3748.76317	7.59429	65	5.65860	500.41615	2.31966	93	7.94066	1.74989	76.039	0.08417	0.11932
ABC.PE.P1; peptide/nickel transport system permease protein	11.37500	3.43884	19.55385	3748.76317	7.59429	65	5.65860	500.41615	2.31966	93	7.94066	1.74989	76.039	0.08417	0.11932
ABC.FEV.S; iron complex transport system substrate-binding protein	11.29937	3.43399	19.42462	3743.51591	7.58898	65	5.62043	496.13634	2.30972	93	7.93268	1.74017	75.952	0.08588	0.11932
TC.AGCS; alanine or glycine:cation symporter, AGCS family	10.53449	3.02673	17.46769	2828.35294	6.59645	65	5.68871	444.85760	2.18710	93	6.94957	1.69492	78.187	0.09407	0.12021
K07485; transposase	10.05823	2.97089	17.79462	2768.09329	6.52580	65	4.65108	382.33228	2.02758	93	6.83353	1.92339	76.457	0.05815	0.11932
pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3]	9.60000	2.93553	16.61692	2740.27049	6.49292	65	4.69570	358.11813	1.96233	93	6.78297	1.75752	75.786	0.08287	0.11932
por, nifJ; pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-]	9.22405	2.90961	16.17192	2710.89005	6.45802	65	4.36801	338.86450	1.90885	93	6.73422	1.75283	75.272	0.08370	0.11932
TC.FEV.OM; iron complex outermembrane recepter protein	8.38987	2.48016	14.20692	1939.81569	5.46290	65	4.32419	268.49560	1.69913	93	5.72105	1.72743	76.484	0.08813	0.11932
nhaC; Na+:H+ antiporter, NhaC family	8.19873	2.46629	13.92385	1923.00016	5.43917	65	4.19731	262.96195	1.68153	93	5.69317	1.70846	76.333	0.09162	0.11932
relE, stbE; mRNA interferase RelE/StbE	7.73722	2.35253	13.46092	1748.85886	5.18705	65	3.73677	236.32436	1.59409	93	5.42648	1.79198	76.187	0.07711	0.11932
bigA; putative surface-exposed virulence protein	6.65506	1.97635	11.77692	1226.98266	4.34473	65	3.07527	168.12607	1.34455	93	4.54802	1.91329	76.358	0.05946	0.11932
ABC.CD.P; putative ABC transport system permease protein	6.65063	1.97652	11.37462	1232.14243	4.35385	65	3.34892	169.41625	1.34970	93	4.55826	1.76069	76.401	0.08229	0.11932
ABC.PE.A; peptide/nickel transport system ATP-binding protein	6.65063	1.97652	11.37462	1232.14243	4.35385	65	3.34892	169.41625	1.34970	93	4.55826	1.76069	76.401	0.08229	0.11932
K07133; uncharacterized protein	6.64430	1.98169	11.25346	1227.76342	4.34611	65	3.42285	179.27009	1.38839	93	4.56249	1.71630	77.170	0.09012	0.11932
pbuG; putative MFS transporter, AGZA family, xanthine/uracil permease	6.56867	1.97658	11.12423	1224.45205	4.34024	65	3.38468	176.70393	1.37842	93	4.55387	1.69955	77.017	0.09325	0.11932
fucA; L-fuculose-phosphate aldolase [EC:4.1.2.17]	6.33544	1.97139	10.61538	1212.67788	4.31933	65	3.34409	182.29880	1.40007	93	4.54057	1.60141	77.560	0.11335	0.13801
aroE; shikimate dehydrogenase [EC:1.1.1.25]	6.27468	1.94810	10.92962	1211.22070	4.31673	65	3.02124	154.67310	1.28963	93	4.50525	1.75537	75.516	0.08325	0.11932
ABCC-BAC; ATP-binding cassette, subfamily C, bacterial	6.20127	1.94264	11.00154	1203.15390	4.30233	65	2.84624	152.91012	1.28226	93	4.48935	1.81659	75.461	0.07325	0.11932
cysS1; cysteinyl-tRNA synthetase, unknown class [EC:6.1.1.16]	6.20127	1.94264	11.00154	1203.15390	4.30233	65	2.84624	152.91012	1.28226	93	4.48935	1.81659	75.461	0.07325	0.11932
K07005; uncharacterized protein	6.20127	1.94264	11.00154	1203.15390	4.30233	65	2.84624	152.91012	1.28226	93	4.48935	1.81659	75.461	0.07325	0.11932
E4.3.1.4; formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4]	6.05000	1.93322	10.74308	1197.49116	4.29220	65	2.76989	148.22957	1.26248	93	4.47401	1.78211	75.162	0.07877	0.11932
fctD; glutamate formiminotransferase [EC:2.1.2.5]	6.05000	1.93322	10.74308	1197.49116	4.29220	65	2.76989	148.22957	1.26248	93	4.47401	1.78211	75.162	0.07877	0.11932
metB; cystathionine gamma-synthase [EC:2.5.1.48]	6.05000	1.93322	10.74308	1197.49116	4.29220	65	2.76989	148.22957	1.26248	93	4.47401	1.78211	75.162	0.07877	0.11932
rimJ; [ribosomal protein S5]-alanine N-acetyltransferase [EC:2.3.1.267]	6.05000	1.93322	10.74308	1197.49116	4.29220	65	2.76989	148.22957	1.26248	93	4.47401	1.78211	75.162	0.07877	0.11932
hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	5.54968	1.54748	8.99731	724.52992	3.33865	65	3.14005	127.39306	1.17039	93	3.53786	1.65559	79.858	0.10173	0.12559
gltS; glutamate:Na+ symporter, ESS family	5.50981	1.54289	8.97269	718.62507	3.32502	65	3.08952	127.55157	1.17112	93	3.52524	1.66887	80.007	0.09905	0.12265
mnmA, trmU; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]	5.32500	1.51819	8.81077	711.30904	3.30805	65	2.88871	112.06120	1.09771	93	3.48542	1.69909	78.210	0.09328	0.11932
xerD; integrase/recombinase XerD	5.32500	1.51819	8.81077	711.30904	3.30805	65	2.88871	112.06120	1.09771	93	3.48542	1.69909	78.210	0.09328	0.11932
recG; ATP-dependent DNA helicase RecG [EC:3.6.4.12]	5.20949	1.50878	8.65692	703.04315	3.28878	65	2.80000	110.45380	1.08981	93	3.46464	1.69049	78.171	0.09492	0.12117
cbiN; cobalt/nickel transport protein	5.13570	1.56870	8.85354	776.57971	3.45650	65	2.53720	106.68874	1.07107	93	3.61864	1.74550	76.391	0.08492	0.11932
ABC.CD.A; putative ABC transport system ATP-binding protein	5.10032	1.49320	8.62423	698.94277	3.27917	65	2.63737	100.05373	1.03723	93	3.43930	1.74072	76.912	0.08573	0.11932
ACADS, bcd; butyryl-CoA dehydrogenase [EC:1.3.8.1]	5.02468	1.48807	8.49500	696.41057	3.27323	65	2.59919	98.13895	1.02726	93	3.43064	1.71858	76.710	0.08973	0.11932
ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]	5.02468	1.48807	8.49500	696.41057	3.27323	65	2.59919	98.13895	1.02726	93	3.43064	1.71858	76.710	0.08973	0.11932
K07052; uncharacterized protein	5.01468	1.56089	8.64677	772.73953	3.44794	65	2.47613	103.52967	1.05509	93	3.60576	1.71133	76.083	0.09109	0.11932
oppF; oligopeptide transport system ATP-binding protein	5.01468	1.56089	8.64677	772.73953	3.44794	65	2.47613	103.52967	1.05509	93	3.60576	1.71133	76.083	0.09109	0.11932
PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]	5.01468	1.56089	8.64677	772.73953	3.44794	65	2.47613	103.52967	1.05509	93	3.60576	1.71133	76.083	0.09109	0.11932
pepD; dipeptidase D [EC:3.4.13.-]	4.80000	1.46776	8.30846	685.06762	3.24646	65	2.34785	89.52953	0.98116	93	3.39149	1.75752	75.786	0.08287	0.11932
SPP; sucrose-6-phosphatase [EC:3.1.3.24]	4.22405	1.12022	6.43346	345.57026	2.30575	65	2.67984	92.10404	0.99517	93	2.51134	1.49467	87.942	0.13858	0.16692
ABC.PA.S; polar amino acid transport system substrate-binding protein	3.96582	1.06006	6.34346	334.19049	2.26746	65	2.30403	63.72447	0.82777	93	2.41384	1.67345	81.192	0.09809	0.12260
cysK; cysteine synthase A [EC:2.5.1.47]	3.76203	1.12515	6.61011	401.30779	2.48475	65	1.77143	52.43381	0.75087	93	2.59572	1.86410	75.783	0.06618	0.11932
patB, malY; cystathione beta-lyase [EC:4.4.1.8]	3.73481	1.03780	6.03577	321.11350	2.22266	65	2.12661	60.66108	0.80763	93	2.36484	1.65303	81.033	0.10219	0.12579
sigH; RNA polymerase sporulation-specific sigma factor	3.73481	1.03780	6.03577	321.11350	2.22266	65	2.12661	60.66108	0.80763	93	2.36484	1.65303	81.033	0.10219	0.12579
E5.2.1.8; peptidylprolyl isomerase [EC:5.2.1.8]	3.67559	1.11913	6.46242	398.97632	2.47752	65	1.72780	50.82876	0.73929	93	2.58547	1.83124	75.488	0.07101	0.11932
K07483; transposase	3.67559	1.11913	6.46242	398.97632	2.47752	65	1.72780	50.82876	0.73929	93	2.58547	1.83124	75.488	0.07101	0.11932
PTS-Ntr-EIIA, ptsN; PTS system, nitrogen regulatory IIA component [EC:2.7.1.-]	3.66551	1.02272	6.02769	322.23369	2.22653	65	2.01452	51.16393	0.74172	93	2.34683	1.71004	78.322	0.09122	0.11932
uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12]	3.66551	1.02272	6.02769	322.23369	2.22653	65	2.01452	51.16393	0.74172	93	2.34683	1.71004	78.322	0.09122	0.11932
waaF, rfaF; heptosyltransferase II [EC:2.4.-.-]	3.62563	1.01776	6.00308	318.17548	2.21247	65	1.96398	51.17139	0.74177	93	2.33350	1.73092	78.507	0.08740	0.11932
K01436; amidohydrolase [EC:3.5.1.-]	3.61930	1.02876	5.88192	315.62935	2.20360	65	2.03790	59.64663	0.80085	93	2.34461	1.63951	81.039	0.10498	0.12883
fucO; lactaldehyde reductase [EC:1.1.1.77]	3.58915	1.11363	6.31473	397.01713	2.47143	65	1.68418	49.28762	0.72799	93	2.57642	1.79728	75.194	0.07631	0.11932
AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
ABC.SS.P; simple sugar transport system permease protein	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
alr; alanine racemase [EC:5.1.1.1]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
chrA; chromate transporter	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
cobQ, cbiP; adenosylcobyric acid synthase [EC:6.3.5.10]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
E4.2.1.46, rfbB, rffG; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
exbB; biopolymer transport protein ExbB	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
exbD; biopolymer transport protein ExbD	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
fldA, nifF, isiB; flavodoxin I	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
fusA, GFM, EFG; elongation factor G	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
gidA, mnmG, MTO1; tRNA uridine 5-carboxymethylaminomethyl modification enzyme	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
glgC; glucose-1-phosphate adenylyltransferase [EC:2.7.7.27]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
K07010; putative glutamine amidotransferase	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
K08303; putative protease [EC:3.4.-.-]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
KAE1, tsaD, QRI7; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
ldhA; D-lactate dehydrogenase [EC:1.1.1.28]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
mreB; rod shape-determining protein MreB and related proteins	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
nudF; ADP-ribose pyrophosphatase [EC:3.6.1.13]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
relA; GTP pyrophosphokinase [EC:2.7.6.5]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
TC.LIVCS; branched-chain amino acid:cation transporter, LIVCS family	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
TC.NSS; neurotransmitter:Na+ symporter, NSS family	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
thiJ; protein deglycase [EC:3.5.1.124]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
tonB; periplasmic protein TonB	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
trkA, ktrA; trk system potassium uptake protein	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
trkH, trkG, ktrB; trk system potassium uptake protein	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9]	3.55000	1.01213	5.87385	316.13735	2.20537	65	1.92581	49.80498	0.73180	93	2.32362	1.69909	78.210	0.09328	0.11932
afuA, fbpA; iron(III) transport system substrate-binding protein	3.51646	1.00309	5.97038	315.37640	2.20271	65	1.80134	44.68020	0.69313	93	2.30919	1.80541	76.778	0.07493	0.11932
abgT; aminobenzoyl-glutamate transport protein	3.47437	1.00692	5.74462	314.38425	2.19925	65	1.88763	48.48749	0.72206	93	2.31475	1.66626	77.912	0.09968	0.12318
galE, GALE; UDP-glucose 4-epimerase [EC:5.1.3.2]	3.47437	1.00692	5.74462	314.38425	2.19925	65	1.88763	48.48749	0.72206	93	2.31475	1.66626	77.912	0.09968	0.12318
afuB, fbpB; iron(III) transport system permease protein	3.44082	0.99758	5.84115	313.42266	2.19588	65	1.76317	43.37766	0.68295	93	2.29963	1.77332	76.483	0.08016	0.11932
afuC, fbpC; iron(III) transport system ATP-binding protein [EC:3.6.3.30]	3.44082	0.99758	5.84115	313.42266	2.19588	65	1.76317	43.37766	0.68295	93	2.29963	1.77332	76.483	0.08016	0.11932
sepF; cell division inhibitor SepF	3.44082	0.99758	5.84115	313.42266	2.19588	65	1.76317	43.37766	0.68295	93	2.29963	1.77332	76.483	0.08016	0.11932
waaY, rfaY; heptose II phosphotransferase [EC:2.7.1.-]	3.44082	0.99758	5.84115	313.42266	2.19588	65	1.76317	43.37766	0.68295	93	2.29963	1.77332	76.483	0.08016	0.11932
bshA; L-malate glycosyltransferase [EC:2.4.1.-]	3.43449	1.00296	5.72000	310.74391	2.18648	65	1.83710	48.79085	0.72432	93	2.30333	1.68578	78.163	0.09583	0.12158
dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]	3.43449	1.00296	5.72000	310.74391	2.18648	65	1.83710	48.79085	0.72432	93	2.30333	1.68578	78.163	0.09583	0.12158
E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	3.43449	1.00296	5.72000	310.74391	2.18648	65	1.83710	48.79085	0.72432	93	2.30333	1.68578	78.163	0.09583	0.12158
pgsA, PGS1; CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	3.43449	1.00296	5.72000	310.74391	2.18648	65	1.83710	48.79085	0.72432	93	2.30333	1.68578	78.163	0.09583	0.12158
smf; DNA processing protein	3.43449	1.00296	5.72000	310.74391	2.18648	65	1.83710	48.79085	0.72432	93	2.30333	1.68578	78.163	0.09583	0.12158
znuA; zinc transport system substrate-binding protein	3.43449	1.00296	5.72000	310.74391	2.18648	65	1.83710	48.79085	0.72432	93	2.30333	1.68578	78.163	0.09583	0.12158
K07497; putative transposase	3.40316	0.99468	6.01769	309.30144	2.18139	65	1.57581	43.39737	0.68311	93	2.28585	1.94321	76.655	0.05566	0.11932
hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]	3.40095	0.99369	5.81654	309.90502	2.18352	65	1.71263	43.64680	0.68507	93	2.28847	1.79330	76.703	0.07687	0.11932
bdhAB; butanol dehydrogenase [EC:1.1.1.-]	3.36519	0.99251	5.71192	311.75395	2.19003	65	1.72500	42.12405	0.67301	93	2.29110	1.74017	76.186	0.08587	0.11932
fixA, etfB; electron transfer flavoprotein beta subunit	3.35886	0.99785	5.59077	309.07513	2.18060	65	1.79892	47.48316	0.71454	93	2.29468	1.65245	77.858	0.10247	0.12588
fixB, etfA; electron transfer flavoprotein alpha subunit	3.35886	0.99785	5.59077	309.07513	2.18060	65	1.79892	47.48316	0.71454	93	2.29468	1.65245	77.858	0.10247	0.12588
APRT, apt; adenine phosphoribosyltransferase [EC:2.4.2.7]	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11932
ccdA; cytochrome c-type biogenesis protein	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11932
E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11932
fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11932
GLO1, gloA; lactoylglutathione lyase [EC:4.4.1.5]	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11932
hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11932
msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12]	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11932
murJ, mviN; putative peptidoglycan lipid II flippase	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11932
mutT, NUDT15, MTH2; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11932
rfbC, rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11932
sppA; protease IV [EC:3.4.21.-]	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11932
thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11932
xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]	3.32532	0.98826	5.68731	308.03561	2.17693	65	1.67446	42.35406	0.67485	93	2.27913	1.76069	76.401	0.08229	0.11932
eutN; ethanolamine utilization protein EutN	3.25190	0.98211	5.75923	304.47491	2.16431	65	1.49946	40.71459	0.66166	93	2.26319	1.88220	76.060	0.06363	0.11932
MMAB, pduO; cob(I)alamin adenosyltransferase [EC:2.5.1.17]	3.25190	0.98211	5.75923	304.47491	2.16431	65	1.49946	40.71459	0.66166	93	2.26319	1.88220	76.060	0.06363	0.11932
TC.OOP; OmpA-OmpF porin, OOP family	3.25190	0.98211	5.75923	304.47491	2.16431	65	1.49946	40.71459	0.66166	93	2.26319	1.88220	76.060	0.06363	0.11932
atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11932
atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11932
dinJ; DNA-damage-inducible protein J	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11932
ecfA2; energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-]	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11932
hepST; heptaprenyl diphosphate synthase [EC:2.5.1.30]	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11932
hutH, HAL; histidine ammonia-lyase [EC:4.3.1.3]	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11932
hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7]	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11932
hutU, UROC1; urocanate hydratase [EC:4.2.1.49]	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11932
lon; ATP-dependent Lon protease [EC:3.4.21.53]	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11932
lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191]	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11932
purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11932
recO; DNA repair protein RecO (recombination protein O)	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11932
TC.GNTP; gluconate:H+ symporter, GntP family	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11932
yuiF; putative amino acid transporter	3.24968	0.98328	5.55808	306.45121	2.17132	65	1.63629	41.11025	0.66487	93	2.27083	1.72703	76.099	0.08822	0.11932
cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 3.6.4.-]	3.18038	0.97932	5.55000	307.96328	2.17667	65	1.52419	37.61829	0.63600	93	2.26768	1.77529	75.014	0.07991	0.11932
cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]	3.18038	0.97932	5.55000	307.96328	2.17667	65	1.52419	37.61829	0.63600	93	2.26768	1.77529	75.014	0.07991	0.11932
cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]	3.18038	0.97932	5.55000	307.96328	2.17667	65	1.52419	37.61829	0.63600	93	2.26768	1.77529	75.014	0.07991	0.11932
ABC.ZM.S; zinc/manganese transport system substrate-binding protein	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
atpI; ATP synthase protein I	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
ATPVG, ahaH, atpH; V/A-type H+/Na+-transporting ATPase subunit G/H	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
bioY; biotin transport system substrate-specific component	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
citG; triphosphoribosyl-dephospho-CoA synthase [EC:2.4.2.52]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
citX; holo-ACP synthase [EC:2.7.7.61]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
CNP; 2’,3’-cyclic-nucleotide 3’-phosphodiesterase [EC:3.1.4.37]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
dam; DNA adenine methylase [EC:2.1.1.72]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
E3.1.3.41; 4-nitrophenyl phosphatase [EC:3.1.3.41]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
E4.1.1.49, pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
ecfA1; energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
eutA; ethanolamine utilization protein EutA	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
eutB; ethanolamine ammonia-lyase large subunit [EC:4.3.1.7]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
eutC; ethanolamine ammonia-lyase small subunit [EC:4.3.1.7]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
eutJ; ethanolamine utilization protein EutJ	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
eutL; ethanolamine utilization protein EutL	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
eutM; ethanolamine utilization protein EutM	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
eutP; ethanolamine utilization protein EutP	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
eutQ; ethanolamine utilization protein EutQ	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
eutS; ethanolamine utilization protein EutS	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
eutT; ethanolamine utilization cobalamin adenosyltransferase [EC:2.5.1.17]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
FTR, FTH1, efeU; high-affinity iron transporter	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
higB-1; toxin HigB-1	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
K00375; GntR family transcriptional regulator / MocR family aminotransferase	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
K06921; uncharacterized protein	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
K07097; uncharacterized protein	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
K09155; uncharacterized protein	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
kptA; putative RNA 2’-phosphotransferase [EC:2.7.1.-]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
licD; lipopolysaccharide cholinephosphotransferase [EC:2.7.8.-]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
lip, TGL2; triacylglycerol lipase [EC:3.1.1.3]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
nasT; two-component system, response regulator / RNA-binding antiterminator	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
ncd2, npd; nitronate monooxygenase [EC:1.13.12.16]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
nifH; nitrogenase iron protein NifH [EC:1.18.6.1]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
nikA; nickel transport system substrate-binding protein	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
nikB; nickel transport system permease protein	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
nikC; nickel transport system permease protein	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
nikD; nickel transport system ATP-binding protein [EC:3.6.3.24]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
nikE; nickel transport system ATP-binding protein [EC:3.6.3.24]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
p19, ftrA; periplasmic iron binding protein	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
pabA; para-aminobenzoate synthetase component II [EC:2.6.1.85]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
pabB; para-aminobenzoate synthetase component I [EC:2.6.1.85]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
pepE; dipeptidase E [EC:3.4.13.21]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
phnC; phosphonate transport system ATP-binding protein [EC:3.6.3.28]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
phnD; phosphonate transport system substrate-binding protein	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
phnE; phosphonate transport system permease protein	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
pip; proline iminopeptidase [EC:3.4.11.5]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
ppnN; pyrimidine/purine-5’-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
troA, mntA, znuA; manganese/zinc/iron transport system substrate-binding protein	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
troB, mntB, znuC; manganese/zinc/iron transport system ATP- binding protein	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
troC, mntC, znuB; manganese/zinc/iron transport system permease protein	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
troD, mntD, znuB; manganese/zinc/iron transport system permease protein	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
trpB; tryptophan synthase beta chain [EC:4.2.1.20]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
UGCG; ceramide glucosyltransferase [EC:2.4.1.80]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
waaL, rfaL; O-antigen ligase [EC:2.4.1.-]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
xlyAB; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
yoeB; toxin YoeB [EC:3.1.-.-]	3.10063	0.97132	5.50077	300.78848	2.15117	65	1.42312	38.22753	0.64113	93	2.24467	1.81659	75.461	0.07325	0.11932
dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]	2.90380	0.81955	4.73846	208.30365	1.79016	65	1.62151	32.15518	0.58801	93	1.88426	1.65421	77.924	0.10211	0.12579
ATPVD, ntpD, atpD; V/A-type H+/Na+-transporting ATPase subunit D	2.77620	0.80531	4.65969	198.44951	1.74730	65	1.45978	32.55303	0.59164	93	1.84475	1.73460	78.796	0.08672	0.11932
ABC-2.A; ABC-2 type transport system ATP-binding protein	2.71899	0.80173	4.49231	200.26635	1.75528	65	1.47957	30.22012	0.57004	93	1.84553	1.63245	77.611	0.10663	0.13060
K07150; uncharacterized protein	2.71899	0.80173	4.49231	200.26635	1.75528	65	1.47957	30.22012	0.57004	93	1.84553	1.63245	77.611	0.10663	0.13060
ATPVA, ntpA, atpA; V/A-type H+/Na+-transporting ATPase subunit A [EC:3.6.3.14 3.6.3.15]	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
ATPVB, ntpB, atpB; V/A-type H+/Na+-transporting ATPase subunit B	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
ATPVC, ntpC, atpC; V/A-type H+/Na+-transporting ATPase subunit C	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
ATPVE, ntpE, atpE; V/A-type H+/Na+-transporting ATPase subunit E	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
ATPVF, ntpF, atpF; V/A-type H+/Na+-transporting ATPase subunit F	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
ATPVI, ntpI, atpI; V/A-type H+/Na+-transporting ATPase subunit I	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
ATPVK, ntpK, atpK; V/A-type H+/Na+-transporting ATPase subunit K	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
dhaK; phosphoenolpyruvate—glycerone phosphotransferase subunit DhaK [EC:2.7.1.121]	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
dhaL; phosphoenolpyruvate—glycerone phosphotransferase subunit DhaL [EC:2.7.1.121]	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
E4.1.99.2; tyrosine phenol-lyase [EC:4.1.99.2]	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
eutH; ethanolamine transporter	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
gspE; general secretion pathway protein E	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
K06885; uncharacterized protein	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
K06889; uncharacterized protein	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
K07006; uncharacterized protein	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
K07160; UPF0271 protein	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
nagD; NagD protein	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
serA, PHGDH; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
tctB; putative tricarboxylic transport membrane protein	2.65519	0.79622	4.45292	195.87416	1.73593	65	1.39871	30.79779	0.57546	93	1.82883	1.67004	78.182	0.09891	0.12260
ABC.PA.P; polar amino acid transport system permease protein	2.15095	0.55238	3.38192	86.52925	1.15378	65	1.29059	20.25715	0.46671	93	1.24460	1.68032	85.073	0.09656	0.12226
ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:3.6.3.21]	2.07532	0.54546	3.25269	84.98520	1.14344	65	1.25242	19.43910	0.45719	93	1.23146	1.62431	84.595	0.10803	0.13205
metQ; D-methionine transport system substrate-binding protein	2.07532	0.54546	3.25269	84.98520	1.14344	65	1.25242	19.43910	0.45719	93	1.23146	1.62431	84.595	0.10803	0.13205
amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	2.04177	0.53016	3.34923	84.89254	1.14282	65	1.12796	14.67633	0.39725	93	1.20990	1.83592	79.592	0.07010	0.11932
yfbK; Ca-activated chloride channel homolog	2.03580	0.57821	3.49495	105.70350	1.27523	65	1.01598	14.05696	0.38878	93	1.33318	1.85945	75.993	0.06683	0.11932
K07090; uncharacterized protein	2.00601	0.53134	3.24462	86.18503	1.15149	65	1.14032	14.32743	0.39250	93	1.21655	1.72973	78.994	0.08758	0.11932
bioB; biotin synthase [EC:2.8.1.6]	1.99968	0.53933	3.12346	83.72617	1.13494	65	1.21425	18.66999	0.44805	93	1.22018	1.56469	84.083	0.12141	0.14666
cspA; cold shock protein (beta-ribbon, CspA family)	1.99968	0.53933	3.12346	83.72617	1.13494	65	1.21425	18.66999	0.44805	93	1.22018	1.56469	84.083	0.12141	0.14666
hupB; DNA-binding protein HU-beta	1.99968	0.53933	3.12346	83.72617	1.13494	65	1.21425	18.66999	0.44805	93	1.22018	1.56469	84.083	0.12141	0.14666
K07137; uncharacterized protein	1.99968	0.53933	3.12346	83.72617	1.13494	65	1.21425	18.66999	0.44805	93	1.22018	1.56469	84.083	0.12141	0.14666
PTS-Fru-EIIC, fruA; PTS system, fructose-specific IIC component	1.99968	0.53933	3.12346	83.72617	1.13494	65	1.21425	18.66999	0.44805	93	1.22018	1.56469	84.083	0.12141	0.14666
rpoD; RNA polymerase primary sigma factor	1.99968	0.53933	3.12346	83.72617	1.13494	65	1.21425	18.66999	0.44805	93	1.22018	1.56469	84.083	0.12141	0.14666
thiH; 2-iminoacetate synthase [EC:4.1.99.19]	1.99968	0.53933	3.12346	83.72617	1.13494	65	1.21425	18.66999	0.44805	93	1.22018	1.56469	84.083	0.12141	0.14666
trxA; thioredoxin 1	1.99968	0.53933	3.12346	83.72617	1.13494	65	1.21425	18.66999	0.44805	93	1.22018	1.56469	84.083	0.12141	0.14666
lexA; repressor LexA [EC:3.4.21.88]	1.99024	0.57132	3.46681	102.81491	1.25768	65	0.95822	13.86942	0.38618	93	1.31564	1.90675	76.166	0.06032	0.11932
tnaA; tryptophanase [EC:4.1.99.1]	1.99024	0.57132	3.46681	102.81491	1.25768	65	0.95822	13.86942	0.38618	93	1.31564	1.90675	76.166	0.06032	0.11932
murI; glutamate racemase [EC:5.1.1.3]	1.96614	0.52335	3.22000	83.43288	1.13295	65	1.08978	13.92216	0.38691	93	1.19720	1.77933	79.051	0.07903	0.11932
ABC.X4.S; putative ABC transport system substrate-binding protein	1.95981	0.53455	3.09885	81.67059	1.12092	65	1.16371	18.67309	0.44809	93	1.20717	1.60304	84.586	0.11265	0.13757
npdA; NAD-dependent deacetylase [EC:3.5.1.-]	1.92627	0.51861	3.19538	81.50000	1.11975	65	1.03925	13.89105	0.38648	93	1.18457	1.82018	79.373	0.07250	0.11932
NTH; endonuclease III [EC:4.2.99.18]	1.92627	0.51861	3.19538	81.50000	1.11975	65	1.03925	13.89105	0.38648	93	1.18457	1.82018	79.373	0.07250	0.11932
citC; [citrate (pro-3S)-lyase] ligase [EC:6.2.1.22]	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
ctpC; manganese/zinc-transporting P-type ATPase C [EC:3.6.3.-]	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
E2.7.1.37; protein kinase [EC:2.7.1.37]	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
E3.5.1.28D, amiD; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
E4.1.1.17, ODC1, speC, speF; ornithine decarboxylase [EC:4.1.1.17]	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
frdA; fumarate reductase flavoprotein subunit [EC:1.3.5.4]	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
glmE, mutE, mamB; methylaspartate mutase epsilon subunit [EC:5.4.99.1]	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
gspF; general secretion pathway protein F	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
hprA; glycerate dehydrogenase [EC:1.1.1.29]	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
K02481; two-component system, NtrC family, response regulator	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
K07085; putative transport protein	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
motB; chemotaxis protein MotB	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
pabC; 4-amino-4-deoxychorismate lyase [EC:4.1.3.38]	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
penP; beta-lactamase class A [EC:3.5.2.6]	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
thrB2; homoserine kinase type II [EC:2.7.1.39]	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]	1.90380	0.56495	3.31912	101.50103	1.24962	65	0.91459	13.04452	0.37452	93	1.30454	1.84320	75.589	0.06922	0.11932
glk; glucokinase [EC:2.7.1.2]	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11932
K07001; NTE family protein	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11932
K07095; uncharacterized protein	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11932
mscS; small conductance mechanosensitive channel	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11932
murF; UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase [EC:6.3.2.10]	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11932
PTS-EI.PTSI, ptsI; phosphotransferase system, enzyme I, PtsI [EC:2.7.3.9]	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11932
pyrF; orotidine-5’-phosphate decarboxylase [EC:4.1.1.23]	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11932
rfbD, rmlD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11932
TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11932
trmB, METTL1; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]	1.89051	0.51736	3.09077	82.25823	1.12495	65	1.05161	13.21693	0.37698	93	1.18644	1.71873	78.493	0.08961	0.11932
K07088; uncharacterized protein	1.88418	0.52855	2.96962	80.49589	1.11283	65	1.12554	17.91378	0.43889	93	1.19625	1.54155	84.043	0.12694	0.15305
tuf, TUFM; elongation factor Tu	1.88418	0.52855	2.96962	80.49589	1.11283	65	1.12554	17.91378	0.43889	93	1.19625	1.54155	84.043	0.12694	0.15305
ABC.X4.A; putative ABC transport system ATP-binding protein	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11932
ABC.X4.P; putative ABC transport system permease protein	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11932
arsR; ArsR family transcriptional regulator, arsenate/arsenite/antimonite-responsive transcriptional repressor	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11932
E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11932
hsdM; type I restriction enzyme M protein [EC:2.1.1.72]	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11932
iscS, NFS1; cysteine desulfurase [EC:2.8.1.7]	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11932
lpxL, htrB; Kdo2-lipid IVA lauroyltransferase [EC:2.3.1.241]	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11932
rnj; ribonuclease J [EC:3.1.-.-]	1.85063	0.51192	3.06615	80.12466	1.11026	65	1.00108	13.14668	0.37598	93	1.17220	1.76171	78.800	0.08200	0.11932
ABC.SS.A; simple sugar transport system ATP-binding protein [EC:3.6.3.17]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ABCF3; ATP-binding cassette, subfamily F, member 3	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ackA; acetate kinase [EC:2.7.2.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
acpP; acyl carrier protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
adk, AK; adenylate kinase [EC:2.7.4.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
apbE; FAD:protein FMN transferase [EC:2.7.1.180]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
APEH; acylaminoacyl-peptidase [EC:3.4.19.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
AROA2, aroA; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
aroC; chorismate synthase [EC:4.2.3.5]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ARSC1, arsC; arsenate reductase [EC:1.20.4.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
asnA; aspartate–ammonia ligase [EC:6.3.1.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
aspB; aspartate aminotransferase [EC:2.6.1.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
aspS; aspartyl-tRNA synthetase [EC:6.1.1.12]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
atoE; short-chain fatty acids transporter	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ATPF0A, atpB; F-type H+-transporting ATPase subunit a	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ATPF0B, atpF; F-type H+-transporting ATPase subunit b	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ATPF0C, atpE; F-type H+-transporting ATPase subunit c	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ATPF1A, atpA; F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ATPF1B, atpD; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ATPF1D, atpH; F-type H+-transporting ATPase subunit delta	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ATPF1E, atpC; F-type H+-transporting ATPase subunit epsilon	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ATPF1G, atpG; F-type H+-transporting ATPase subunit gamma	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
bax; Bax protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
bioA; adenosylmethionine—8-amino-7-oxononanoate aminotransferase [EC:2.6.1.62]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
bioC; malonyl-CoA O-methyltransferase [EC:2.1.1.197]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
bioD; dethiobiotin synthetase [EC:6.3.3.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
bioG; pimeloyl-[acyl-carrier protein] methyl ester esterase [EC:3.1.1.85]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
birA; BirA family transcriptional regulator, biotin operon repressor / biotin—[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
CARP, pepA; leucyl aminopeptidase [EC:3.4.11.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cas1; CRISP-associated protein Cas1	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cas2; CRISPR-associated protein Cas2	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cat2, abfT; 4-hydroxybutyrate CoA-transferase [EC:2.8.3.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cbiB, cobD; adenosylcobinamide-phosphate synthase [EC:6.3.1.10]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cbiD; cobalt-precorrin-5B (C1)-methyltransferase [EC:2.1.1.195]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cbiE; cobalt-precorrin-7 (C5)-methyltransferase [EC:2.1.1.289]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cbiG; cobalt-precorrin 5A hydrolase [EC:3.7.1.12]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cbiK; sirohydrochlorin cobaltochelatase [EC:4.99.1.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cbiT; cobalt-precorrin-6B (C15)-methyltransferase [EC:2.1.1.196]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
CHO1, pssA; CDP-diacylglycerol—serine O-phosphatidyltransferase [EC:2.7.8.8]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cidA; holin-like protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
citD; citrate lyase subunit gamma (acyl carrier protein)	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
clpB; ATP-dependent Clp protease ATP-binding subunit ClpB	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
clpX, CLPX; ATP-dependent Clp protease ATP-binding subunit ClpX	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
clsA_B; cardiolipin synthase A/B [EC:2.7.8.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cmk; CMP/dCMP kinase [EC:2.7.4.25]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
coaBC, dfp; phosphopantothenoylcysteine decarboxylase / phosphopantothenate—cysteine ligase [EC:4.1.1.36 6.3.2.5]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
coaE; dephospho-CoA kinase [EC:2.7.1.24]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
coaX; type III pantothenate kinase [EC:2.7.1.33]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cobA-hemD; uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cobA, btuR; cob(I)alamin adenosyltransferase [EC:2.5.1.17]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cobB-cbiA; cobyrinic acid a,c-diamide synthase [EC:6.3.5.9 6.3.5.11]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cobC, phpB; alpha-ribazole phosphatase [EC:3.1.3.73]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cobD; threonine-phosphate decarboxylase [EC:4.1.1.81]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cobH-cbiC; precorrin-8X/cobalt-precorrin-8 methylmutase [EC:5.4.99.61 5.4.99.60]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cobI-cbiL; precorrin-2/cobalt-factor-2 C20-methyltransferase [EC:2.1.1.130 2.1.1.151]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cobK-cbiJ; precorrin-6A/cobalt-precorrin-6A reductase [EC:1.3.1.54 1.3.1.106]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cobM, cbiF; precorrin-4/cobalt-precorrin-4 C11-methyltransferase [EC:2.1.1.133 2.1.1.271]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cobP, cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
comEA; competence protein ComEA	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
comEB; dCMP deaminase [EC:3.5.4.12]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
comEC; competence protein ComEC	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
comFC; competence protein ComFC	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
comM; magnesium chelatase family protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
copA, ATP7; Cu+-exporting ATPase [EC:3.6.3.54]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
corA; magnesium transporter	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
creD; inner membrane protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
crt; enoyl-CoA hydratase [EC:4.2.1.17]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cutC; copper homeostasis protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cvpA; membrane protein required for colicin V production	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
cvrA, nhaP2; cell volume regulation protein A	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
dacC, dacA, dacD; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
deaD, cshA; ATP-dependent RNA helicase DeaD [EC:3.6.4.13]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
deoD; purine-nucleoside phosphorylase [EC:2.4.2.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
DHFR, folA; dihydrofolate reductase [EC:1.5.1.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
dinG; ATP-dependent DNA helicase DinG [EC:3.6.4.12]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
disA; diadenylate cyclase [EC:2.7.7.85]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
dnaB; replicative DNA helicase [EC:3.6.4.12]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
dnaG; DNA primase [EC:2.7.7.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
dnaJ; molecular chaperone DnaJ	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
dnaK, HSPA9; molecular chaperone DnaK	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
dpo; DNA polymerase bacteriophage-type [EC:2.7.7.7]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
dps; starvation-inducible DNA-binding protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
dtd, DTD1; D-tyrosyl-tRNA(Tyr) deacylase [EC:3.1.-.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
dxr; 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E2.1.1.104; caffeoyl-CoA O-methyltransferase [EC:2.1.1.104]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E2.1.1.131, cobJ, cbiH; precorrin-3B C17-methyltransferase [EC:2.1.1.131]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E2.3.1.54, pflD; formate C-acetyltransferase [EC:2.3.1.54]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E2.3.1.8, pta; phosphate acetyltransferase [EC:2.3.1.8]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E2.3.1.9, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E2.4.2.21, cobU, cobT; nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E2.7.1.71, aroK, aroL; shikimate kinase [EC:2.7.1.71]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E2.7.4.8, gmk; guanylate kinase [EC:2.7.4.8]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E2.7.7.3A, coaD, kdtB; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E3.1.3.15B; histidinol-phosphatase (PHP family) [EC:3.1.3.15]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E3.4.11.-; aminopeptidase [EC:3.4.11.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E3.4.17.19; carboxypeptidase Taq [EC:3.4.17.19]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E3.4.21.102, prc, ctpA; carboxyl-terminal processing protease [EC:3.4.21.102]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E3.6.3.8; Ca2+-transporting ATPase [EC:3.6.3.8]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E4.1.3.3, nanA, NPL; N-acetylneuraminate lyase [EC:4.1.3.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E4.3.1.17, sdaA, sdaB, tdcG; L-serine dehydratase [EC:4.3.1.17]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E4.4.1.11; methionine-gamma-lyase [EC:4.4.1.11]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ecfT; energy-coupling factor transport system permease protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
efp; elongation factor P	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
engA, der; GTPase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
engB; GTP-binding protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ENO, eno; enolase [EC:4.2.1.11]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
era, ERAL1; GTPase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
fadL; long-chain fatty acid transport protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
fbp3; fructose-1,6-bisphosphatase III [EC:3.1.3.11]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
fhs; formate–tetrahydrofolate ligase [EC:6.3.4.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
fnr; CRP/FNR family transcriptional regulator, anaerobic regulatory protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
folP; dihydropteroate synthase [EC:2.5.1.15]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
frr, MRRF, RRF; ribosome recycling factor	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
fruK; 1-phosphofructokinase [EC:2.7.1.56]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
fruR2, fruR; DeoR family transcriptional regulator, fructose operon transcriptional repressor	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ftsA; cell division protein FtsA	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ftsH, hflB; cell division protease FtsH [EC:3.4.24.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ftsQ; cell division protein FtsQ	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ftsW, spoVE; cell division protein FtsW	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ftsX; cell division transport system permease protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ftsY; fused signal recognition particle receptor	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ftsZ; cell division protein FtsZ	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
fur, zur, furB; Fur family transcriptional regulator, ferric uptake regulator	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
galK; galactokinase [EC:2.7.1.6]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
galM, GALM; aldose 1-epimerase [EC:5.1.3.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
galT, GALT; UDPglucose–hexose-1-phosphate uridylyltransferase [EC:2.7.7.12]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gatA, QRSL1; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gatB, PET112; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gatC, GATC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
GBE1, glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gcdA; glutaconyl-CoA decarboxylase [EC:4.1.1.70]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gcpE, ispG; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gctA; glutaconate CoA-transferase, subunit A [EC:2.8.3.12]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gctB; glutaconate CoA-transferase, subunit B [EC:2.8.3.12]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
glgA; starch synthase [EC:2.4.1.21]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
glgX; glycogen debranching enzyme [EC:3.2.1.196]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
glmM; phosphoglucosamine mutase [EC:5.4.2.10]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
glmS, GFPT; glucosamine—fructose-6-phosphate aminotransferase (isomerizing) [EC:2.6.1.16]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
glmS, mutS, mamA; methylaspartate mutase sigma subunit [EC:5.4.99.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
glnG, ntrC; two-component system, NtrC family, nitrogen regulation response regulator GlnG	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gloB, HAGH; hydroxyacylglutathione hydrolase [EC:3.1.2.6]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
GLPF; glycerol uptake facilitator protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
glpK, GK; glycerol kinase [EC:2.7.1.30]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
glpP; glycerol uptake operon antiterminator	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
glpX; fructose-1,6-bisphosphatase II [EC:3.1.3.11]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
glsA, GLS; glutaminase [EC:3.5.1.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gmhA, lpcA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gmhD, rfaD; ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
GPI, pgi; glucose-6-phosphate isomerase [EC:5.3.1.9]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gpmB; probable phosphoglycerate mutase [EC:5.4.2.12]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gpx; glutathione peroxidase [EC:1.11.1.9]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
groEL, HSPD1; chaperonin GroEL	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
groES, HSPE1; chaperonin GroES	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
GRPE; molecular chaperone GrpE	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gspD; general secretion pathway protein D	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gspG; general secretion pathway protein G	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gudB, rocG; glutamate dehydrogenase [EC:1.4.1.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gyrA; DNA gyrase subunit A [EC:5.99.1.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
gyrB; DNA gyrase subunit B [EC:5.99.1.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
hcp; hydroxylamine reductase [EC:1.7.99.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
hemA; glutamyl-tRNA reductase [EC:1.2.1.70]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
hemC, HMBS; hydroxymethylbilane synthase [EC:2.5.1.61]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
hemK, prmC, HEMK; release factor glutamine methyltransferase [EC:2.1.1.297]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
hemL; glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
hflX; GTPase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
HINT1, hinT, hit; histidine triad (HIT) family protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
hlpA, ompH; outer membrane protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
hlyIII; hemolysin III	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
holA; DNA polymerase III subunit delta [EC:2.7.7.7]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
holB; DNA polymerase III subunit delta’ [EC:2.7.7.7]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
hppA; K(+)-stimulated pyrophosphate-energized sodium pump [EC:3.6.1.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
hprK, ptsK; HPr kinase/phosphorylase [EC:2.7.11.- 2.7.4.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
hrcA; heat-inducible transcriptional repressor	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
hslO; molecular chaperone Hsp33	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
HSP90A, htpG; molecular chaperone HtpG	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
htpX; heat shock protein HtpX [EC:3.4.24.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
hutG; formiminoglutamase [EC:3.5.3.8]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
infA; translation initiation factor IF-1	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
infB, MTIF2; translation initiation factor IF-2	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
infC, MTIF3; translation initiation factor IF-3	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
iscU, nifU; nitrogen fixation protein NifU and related proteins	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ispH, lytB; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
jag; spoIIIJ-associated protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K00243; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K01163; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K02477; two-component system, LytTR family, response regulator	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K03653; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K06890; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K06894; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K06960; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K06975; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K07030; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K07035; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K07037; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K07043; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K07058; membrane protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K07069; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K07082; UPF0755 protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K07105; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K07120; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K07124; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K07139; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K07461; putative endonuclease	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K08884; serine/threonine protein kinase, bacterial [EC:2.7.11.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K08974; putative membrane protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K08998; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K09125; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K09729; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K09747; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K09762; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K09769; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K09778; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K09787; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K09790; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K09802; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K09861; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K09949; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K11145; ribonuclease III family protein [EC:3.1.26.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
kal; 3-aminobutyryl-CoA ammonia-lyase [EC:4.3.1.14]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
kamA; lysine 2,3-aminomutase [EC:5.4.3.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
kamD; beta-lysine 5,6-aminomutase alpha subunit [EC:5.4.3.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
kamE; beta-lysine 5,6-aminomutase beta subunit [EC:5.4.3.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
kce; 3-keto-5-aminohexanoate cleavage enzyme [EC:2.3.1.247]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
kdd; L-erythro-3,5-diaminohexanoate dehydrogenase [EC:1.4.1.11]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
kdsD, kpsF; arabinose-5-phosphate isomerase [EC:5.3.1.13]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
LDH, ldh; L-lactate dehydrogenase [EC:1.1.1.27]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
lemA; LemA protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
lepA; GTP-binding protein LepA	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
lepB; signal peptidase I [EC:3.4.21.89]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
lgt, umpA; phosphatidylglycerol:prolipoprotein diacylglycerol transferase [EC:2.-.-.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
livF; branched-chain amino acid transport system ATP-binding protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
livG; branched-chain amino acid transport system ATP-binding protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
livH; branched-chain amino acid transport system permease protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
livK; branched-chain amino acid transport system substrate-binding protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
livM; branched-chain amino acid transport system permease protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
lolC_E; lipoprotein-releasing system permease protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
lolD; lipoprotein-releasing system ATP-binding protein [EC:3.6.3.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
lptB; lipopolysaccharide export system ATP-binding protein [EC:3.6.3.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
lptF; lipopolysaccharide export system permease protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
lptG; lipopolysaccharide export system permease protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
lpxC; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [EC:3.5.1.108]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
lpxK; tetraacyldisaccharide 4’-kinase [EC:2.7.1.130]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
lspA; signal peptidase II [EC:3.4.23.36]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ltaE; threonine aldolase [EC:4.1.2.48]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
lysE, argO; L-lysine exporter family protein LysE/ArgO	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
maf; septum formation protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
malQ; 4-alpha-glucanotransferase [EC:2.4.1.25]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
map; methionyl aminopeptidase [EC:3.4.11.18]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
MET8; precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:1.3.1.76 4.99.1.4]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
metH, MTR; 5-methyltetrahydrofolate–homocysteine methyltransferase [EC:2.1.1.13]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
metI; D-methionine transport system permease protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
metK; S-adenosylmethionine synthetase [EC:2.5.1.6]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
metN; D-methionine transport system ATP-binding protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mfd; transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mglA; methyl-galactoside transport system ATP-binding protein [EC:3.6.3.17]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mglB; methyl-galactoside transport system substrate-binding protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mglC; methyl-galactoside transport system permease protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mgtC; putative Mg2+ transporter-C (MgtC) family protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mgtE; magnesium transporter	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
minC; septum site-determining protein MinC	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
minD; septum site-determining protein MinD	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
minE; cell division topological specificity factor	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mipA, ompV; MipA family protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mlaA, vacJ; phospholipid-binding lipoprotein MlaA	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mraW, rsmH; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mrcA; penicillin-binding protein 1A [EC:2.4.1.129 3.4.16.4]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mrdA; penicillin-binding protein 2 [EC:3.4.16.4]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mreC; rod shape-determining protein MreC	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:3.6.3.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mscL; large conductance mechanosensitive channel	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mtnN, mtn, pfs; adenosylhomocysteine nucleosidase [EC:3.2.2.9]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
murC; UDP-N-acetylmuramate–alanine ligase [EC:6.3.2.8]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
murD; UDP-N-acetylmuramoylalanine–D-glutamate ligase [EC:6.3.2.9]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase [EC:6.3.2.13]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
murG; UDP-N-acetylglucosamine–N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mutL; DNA mismatch repair protein MutL	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mutS; DNA mismatch repair protein MutS	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
mutS2; DNA mismatch repair protein MutS2	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
nadA; quinolinate synthase [EC:2.5.1.72]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
nadB; L-aspartate oxidase [EC:1.4.3.16]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
nadE; NAD+ synthase [EC:6.3.1.5]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
nagA, AMDHD2; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
nanE; N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
nrdR; transcriptional repressor NrdR	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
nusA; N utilization substance protein A	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
nusB; N utilization substance protein B	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
nusG; transcriptional antiterminator NusG	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
oadA; oxaloacetate decarboxylase, alpha subunit [EC:4.1.1.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
oadB; oxaloacetate decarboxylase, beta subunit [EC:4.1.1.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
obgE, cgtA; GTPase [EC:3.6.5.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ogt, MGMT; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
oppD; oligopeptide transport system ATP-binding protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
opuA; osmoprotectant transport system ATP-binding protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
opuBD; osmoprotectant transport system permease protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
paaH, hbd, fadB, mmgB; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
panF; sodium/pantothenate symporter	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pbpC; penicillin-binding protein 1C [EC:2.4.1.129]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pcp; pyroglutamyl-peptidase [EC:3.4.19.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
PDF, def; peptide deformylase [EC:3.5.1.88]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pdxS, pdx1; pyridoxal 5’-phosphate synthase pdxS subunit [EC:4.3.3.6]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pepF, pepB; oligoendopeptidase F [EC:3.4.24.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pepQ; Xaa-Pro dipeptidase [EC:3.4.13.9]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pepT; tripeptide aminopeptidase [EC:3.4.11.4]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
perR; Fur family transcriptional regulator, peroxide stress response regulator	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pflA, pflC, pflE; pyruvate formate lyase activating enzyme [EC:1.97.1.4]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pgm; phosphoglucomutase [EC:5.4.2.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pgpA; phosphatidylglycerophosphatase A [EC:3.1.3.27]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pheB; chorismate mutase [EC:5.4.99.5]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pilB; type IV pilus assembly protein PilB	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pilC; type IV pilus assembly protein PilC	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pilD, pppA; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pilT; twitching motility protein PilT	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
PK, pyk; pyruvate kinase [EC:2.7.1.40]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
plsX; glycerol-3-phosphate acyltransferase PlsX [EC:2.3.1.15]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
plsY; glycerol-3-phosphate acyltransferase PlsY [EC:2.3.1.15]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pncB, NAPRT1; nicotinate phosphoribosyltransferase [EC:6.3.4.21]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
polA; DNA polymerase I [EC:2.7.7.7]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
potA; spermidine/putrescine transport system ATP-binding protein [EC:3.6.3.31]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
potB; spermidine/putrescine transport system permease protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
potC; spermidine/putrescine transport system permease protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
potD; spermidine/putrescine transport system substrate-binding protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ppaC; manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
PPIB, ppiB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ppnK, NADK; NAD+ kinase [EC:2.7.1.23]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ppx-gppA; exopolyphosphatase / guanosine-5’-triphosphate,3’-diphosphate pyrophosphatase [EC:3.6.1.11 3.6.1.40]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
PRDX2_4, ahpC; peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC:1.11.1.15]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
prfA, MTRF1, MRF1; peptide chain release factor 1	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
prfB; peptide chain release factor 2	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
priA; primosomal protein N’ (replication factor Y) (superfamily II helicase) [EC:3.6.4.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
PTH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
PTS-Fru-EIIA, fruB; PTS system, fructose-specific IIA component [EC:2.7.1.202]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
PTS-Glc-EIIA, crr; PTS system, sugar-specific IIA component [EC:2.7.1.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
PTS-HPR.PTSH, ptsH; phosphocarrier protein HPr	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
PTS-HPR; phosphocarrier protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
PTS-Nag-EIIC, nagE; PTS system, N-acetylglucosamine-specific IIC component	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
purB, ADSL; adenylosuccinate lyase [EC:4.3.2.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
purD; phosphoribosylamine—glycine ligase [EC:6.3.4.13]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
purL, PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
putP; sodium/proline symporter	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pyrB, PYR2; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pyrDII; dihydroorotate dehydrogenase electron transfer subunit	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pyrH; uridylate kinase [EC:2.7.4.22]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
pyrP, uraA; uracil permease	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
queH; epoxyqueuosine reductase [EC:1.17.99.6]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
radA, sms; DNA repair protein RadA/Sms	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
radC; DNA repair protein RadC	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rapZ; RNase adapter protein RapZ	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rbfA; ribosome-binding factor A	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rbgA; ribosome biogenesis GTPase A	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
recA; recombination protein RecA	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
recF; DNA replication and repair protein RecF	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
recN; DNA repair protein RecN (Recombination protein N)	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
recQ; ATP-dependent DNA helicase RecQ [EC:3.6.4.12]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
recR; recombination protein RecR	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
recX; regulatory protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rho; transcription termination factor Rho	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ribH, RIB4; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ridA, tdcF, RIDA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rimI; [ribosomal protein S18]-alanine N-acetyltransferase [EC:2.3.1.266]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rimM; 16S rRNA processing protein RimM	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rimP; ribosome maturation factor RimP	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rlmB; 23S rRNA (guanosine2251-2’-O)-methyltransferase [EC:2.1.1.185]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rluC; 23S rRNA pseudouridine955/2504/2580 synthase [EC:5.4.99.24]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rnfA; electron transport complex protein RnfA	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rnfC; electron transport complex protein RnfC	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rnfD; electron transport complex protein RnfD	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rnfE; electron transport complex protein RnfE	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rnfG; electron transport complex protein RnfG	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rng, cafA; ribonuclease G [EC:3.1.26.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rnhB; ribonuclease HII [EC:3.1.26.4]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rnmV; ribonuclease M5 [EC:3.1.26.8]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rnpA; ribonuclease P protein component [EC:3.1.26.5]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rnr, vacB; ribonuclease R [EC:3.1.-.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rny; ribonucrease Y [EC:3.1.-.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rodA, mrdB; rod shape determining protein RodA	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L1, MRPL1, rplA; large subunit ribosomal protein L1	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L10, MRPL10, rplJ; large subunit ribosomal protein L10	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L11, MRPL11, rplK; large subunit ribosomal protein L11	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L13, MRPL13, rplM; large subunit ribosomal protein L13	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L14, MRPL14, rplN; large subunit ribosomal protein L14	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L15, MRPL15, rplO; large subunit ribosomal protein L15	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L16, MRPL16, rplP; large subunit ribosomal protein L16	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L17, MRPL17, rplQ; large subunit ribosomal protein L17	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L18, MRPL18, rplR; large subunit ribosomal protein L18	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L19, MRPL19, rplS; large subunit ribosomal protein L19	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L2, MRPL2, rplB; large subunit ribosomal protein L2	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L20, MRPL20, rplT; large subunit ribosomal protein L20	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L21, MRPL21, rplU; large subunit ribosomal protein L21	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L22, MRPL22, rplV; large subunit ribosomal protein L22	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L23, MRPL23, rplW; large subunit ribosomal protein L23	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L24, MRPL24, rplX; large subunit ribosomal protein L24	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L27, MRPL27, rpmA; large subunit ribosomal protein L27	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L28, MRPL28, rpmB; large subunit ribosomal protein L28	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L29, rpmC; large subunit ribosomal protein L29	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L30, MRPL30, rpmD; large subunit ribosomal protein L30	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L31, rpmE; large subunit ribosomal protein L31	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L32, MRPL32, rpmF; large subunit ribosomal protein L32	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L33, MRPL33, rpmG; large subunit ribosomal protein L33	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L34, MRPL34, rpmH; large subunit ribosomal protein L34	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L35, MRPL35, rpmI; large subunit ribosomal protein L35	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L36, MRPL36, rpmJ; large subunit ribosomal protein L36	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L4, MRPL4, rplD; large subunit ribosomal protein L4	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L5, MRPL5, rplE; large subunit ribosomal protein L5	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L6, MRPL6, rplF; large subunit ribosomal protein L6	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L7, MRPL12, rplL; large subunit ribosomal protein L7/L12	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-L9, MRPL9, rplI; large subunit ribosomal protein L9	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S10, MRPS10, rpsJ; small subunit ribosomal protein S10	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S11, MRPS11, rpsK; small subunit ribosomal protein S11	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S13, rpsM; small subunit ribosomal protein S13	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S14, MRPS14, rpsN; small subunit ribosomal protein S14	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S15, MRPS15, rpsO; small subunit ribosomal protein S15	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S16, MRPS16, rpsP; small subunit ribosomal protein S16	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S17, MRPS17, rpsQ; small subunit ribosomal protein S17	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S19, rpsS; small subunit ribosomal protein S19	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S20, rpsT; small subunit ribosomal protein S20	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S3, rpsC; small subunit ribosomal protein S3	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S4, rpsD; small subunit ribosomal protein S4	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S5, MRPS5, rpsE; small subunit ribosomal protein S5	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S7, MRPS7, rpsG; small subunit ribosomal protein S7	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S8, rpsH; small subunit ribosomal protein S8	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
RP-S9, MRPS9, rpsI; small subunit ribosomal protein S9	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rpe, RPE; ribulose-phosphate 3-epimerase [EC:5.1.3.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rpoC; DNA-directed RNA polymerase subunit beta’ [EC:2.7.7.6]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rpoE; RNA polymerase sigma-70 factor, ECF subfamily	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rsbU_P; phosphoserine phosphatase RsbU/P [EC:3.1.3.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rsbV; anti-sigma B factor antagonist	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rsbW; serine/threonine-protein kinase RsbW [EC:2.7.11.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rseC; sigma-E factor negative regulatory protein RseC	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rseP; regulator of sigma E protease [EC:3.4.24.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rsmB, sun; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rsmC; 16S rRNA (guanine1207-N2)-methyltransferase [EC:2.1.1.172]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rsmI; 16S rRNA (cytidine1402-2’-O)-methyltransferase [EC:2.1.1.198]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rtpR; ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ruvA; holliday junction DNA helicase RuvA [EC:3.6.4.12]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ruvB; holliday junction DNA helicase RuvB [EC:3.6.4.12]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ruvX; putative holliday junction resolvase [EC:3.1.-.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
SAM50, TOB55, bamA; outer membrane protein insertion porin family	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
sbcC, rad50; DNA repair protein SbcC/Rad50	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
scpA; segregation and condensation protein A	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
scpB; segregation and condensation protein B	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
secA; preprotein translocase subunit SecA	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
secD; preprotein translocase subunit SecD	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
secE; preprotein translocase subunit SecE	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
secF; preprotein translocase subunit SecF	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
secG; preprotein translocase subunit SecG	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
secY; preprotein translocase subunit SecY	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
slyD; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
smc; chromosome segregation protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
smpB; SsrA-binding protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
splB; spore photoproduct lyase [EC:4.1.99.14]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
spoIID; stage II sporulation protein D	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
spoT; GTP diphosphokinase / guanosine-3’,5’-bis(diphosphate) 3’-diphosphatase [EC:2.7.6.5 3.1.7.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
spoU; RNA methyltransferase, TrmH family	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
spoVG; stage V sporulation protein G	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ssb; single-strand DNA-binding protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
sulD; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:4.1.2.25 2.7.6.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
tagD; glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
tatD; TatD DNase family protein [EC:3.1.21.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
TC.GPH; glycoside/pentoside/hexuronide:cation symporter, GPH family	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
TC.OMF; outer membrane factor, OMF family	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
tctA; putative tricarboxylic transport membrane protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
tex; protein Tex	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
tgt, QTRT1; queuine tRNA-ribosyltransferase [EC:2.4.2.29]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
thiF; sulfur carrier protein ThiS adenylyltransferase [EC:2.7.7.73]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
thiG; thiazole synthase [EC:2.8.1.10]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
thiS; sulfur carrier protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
thyA, TYMS; thymidylate synthase [EC:2.1.1.45]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
tig; trigger factor	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
tlyA; 23S rRNA (cytidine1920-2’-O)/16S rRNA (cytidine1409-2’-O)-methyltransferase [EC:2.1.1.226 2.1.1.227]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
tlyC; putative hemolysin	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
tmk, DTYMK; dTMP kinase [EC:2.7.4.9]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
topA; DNA topoisomerase I [EC:5.99.1.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
TPI, tpiA; triosephosphate isomerase (TIM) [EC:5.3.1.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
trmFO, gid; methylenetetrahydrofolate–tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
trmL, cspR; tRNA (cytidine/uridine-2’-O-)-methyltransferase [EC:2.1.1.207]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
truA, PUS1; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
truB, PUS4, TRUB1; tRNA pseudouridine55 synthase [EC:5.4.99.25]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
tsaC, rimN, SUA5; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
tsf, TSFM; elongation factor Ts	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
typA, bipA; GTP-binding protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
tyrB; aromatic-amino-acid transaminase [EC:2.6.1.57]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
UGP2, galU, galF; UTP–glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
URA4, pyrC; dihydroorotase [EC:3.5.2.3]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
uvrA; excinuclease ABC subunit A	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
uvrB; excinuclease ABC subunit B	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
uvrC; excinuclease ABC subunit C	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
yajC; preprotein translocase subunit YajC	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ybaK, ebsC; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ybcJ; ribosome-associated protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ybeY, yqfG; probable rRNA maturation factor	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ybjD; putative ATP-dependent endonuclease of the OLD family	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ycaJ; putative ATPase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ychF; ribosome-binding ATPase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
yesN; two-component system, response regulator YesN	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
yfiH; polyphenol oxidase [EC:1.10.3.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
yggS, PROSC; PLP dependent protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
yggT; YggT family protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
yhbH; putative sigma-54 modulation protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
yhbY; RNA-binding protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
yjbB; phosphate:Na+ symporter	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ylxR; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
yqeH; 30S ribosome assembly GTPase	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
yraN; putative endonuclease	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
ysxB; uncharacterized protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
zntA; Cd2+/Zn2+-exporting ATPase [EC:3.6.3.3 3.6.3.5]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
znuB; zinc transport system permease protein	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
znuC; zinc transport system ATP-binding protein [EC:3.6.3.-]	1.77500	0.50606	2.93692	79.03434	1.10268	65	0.96290	12.45124	0.36590	93	1.16181	1.69909	78.210	0.09328	0.11932
K03710; GntR family transcriptional regulator	0.92405	0.31524	1.23077	22.49279	0.58825	65	0.70968	11.03436	0.34445	93	0.68168	0.76442	106.687	0.44630	0.48091
abfD; 4-hydroxybutyryl-CoA dehydratase / vinylacetyl-CoA-Delta-isomerase [EC:4.2.1.120 5.3.3.3]	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.37911
dapD; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [EC:2.3.1.117]	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.37911
DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4]	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.37911
mgtA, mgtB; Mg2+-importing ATPase [EC:3.6.3.2]	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.37911
murR; RpiR family transcriptional regulator, murPQ operon repressor	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.37911
pheC; cyclohexadienyl dehydratase [EC:4.2.1.51 4.2.1.91]	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.37911
pstC; phosphate transport system permease protein	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.37911
PTS-Fru2-EIIB; PTS system, fructose-specific IIB-like component [EC:2.7.1.-]	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.37911
PTS-Ula-EIIA, ulaC, sgaA; PTS system, ascorbate-specific IIA component [EC:2.7.1.194]	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.37911
PTS-Ula-EIIB, ulaB, sgaB; PTS system, ascorbate-specific IIB component [EC:2.7.1.194]	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.37911
PTS-Ula-EIIC, ulaA, sgaT; PTS system, ascorbate-specific IIC component	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.37911
recT; recombination protein RecT	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.37911
rlpA; rare lipoprotein A	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.37911
udp, UPP; uridine phosphorylase [EC:2.4.2.3]	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.37911
xtmA; phage terminase small subunit	0.87342	0.60746	0.26154	4.44615	0.26154	65	1.30108	95.95185	1.01575	93	1.04888	-0.99110	103.946	0.32394	0.37911
accB, bccP; acetyl-CoA carboxylase biotin carboxyl carrier protein	0.68038	0.21806	0.68077	5.95216	0.30261	65	0.68011	8.67984	0.30550	93	0.43000	0.00154	151.478	0.99877	0.99877
E3.1.3.97; 3’,5’-nucleoside bisphosphate phosphatase [EC:3.1.3.97]	0.68038	0.21806	0.68077	5.95216	0.30261	65	0.68011	8.67984	0.30550	93	0.43000	0.00154	151.478	0.99877	0.99877
FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	0.68038	0.21806	0.68077	5.95216	0.30261	65	0.68011	8.67984	0.30550	93	0.43000	0.00154	151.478	0.99877	0.99877
lacI, galR; LacI family transcriptional regulator	0.68038	0.21806	0.68077	5.95216	0.30261	65	0.68011	8.67984	0.30550	93	0.43000	0.00154	151.478	0.99877	0.99877
PTS-MalGlc-EIIC, malX; PTS system, maltose/glucose-specific IIC component	0.68038	0.21806	0.68077	5.95216	0.30261	65	0.68011	8.67984	0.30550	93	0.43000	0.00154	151.478	0.99877	0.99877
xdhC; xanthine dehydrogenase accessory factor	0.61603	0.21016	0.82051	9.99679	0.39217	65	0.47312	4.90416	0.22964	93	0.45446	0.76442	106.687	0.44630	0.48091
cwlK; peptidoglycan LD-endopeptidase CwlK [EC:3.4.-.-]	0.56166	0.14319	0.68440	3.34909	0.22699	65	0.47588	3.18010	0.18492	93	0.29278	0.71219	135.592	0.47757	0.51415
TC.SSS; solute:Na+ symporter, SSS family	0.46799	0.18465	0.39824	1.35538	0.14440	65	0.51674	8.24487	0.29775	93	0.33092	-0.35810	130.027	0.72085	0.73877
K07496; putative transposase	0.45654	0.10840	0.72205	3.35470	0.22718	65	0.27097	0.75020	0.08981	93	0.24429	1.84651	84.140	0.06833	0.11932
accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
argG, ASS1; argininosuccinate synthase [EC:6.3.4.5]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
argH, ASL; argininosuccinate lyase [EC:4.3.2.1]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
aspA; aspartate ammonia-lyase [EC:4.3.1.1]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
cdd, CDA; cytidine deaminase [EC:3.5.4.5]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
dapF; diaminopimelate epimerase [EC:5.1.1.7]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
dapH, dapD; tetrahydrodipicolinate N-acetyltransferase [EC:2.3.1.89]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
deoC, DERA; deoxyribose-phosphate aldolase [EC:4.1.2.4]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
dfx; superoxide reductase [EC:1.15.1.2]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
E2.7.7.24, rfbA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
E4.2.1.2AA, fumA; fumarate hydratase subunit alpha [EC:4.2.1.2]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
E4.2.1.2AB, fumB; fumarate hydratase subunit beta [EC:4.2.1.2]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
gltD; glutamate synthase (NADPH/NADH) small chain [EC:1.4.1.13 1.4.1.14]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
glxK, garK; glycerate 2-kinase [EC:2.7.1.165]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
K06871; uncharacterized protein	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
K07019; uncharacterized protein	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
K07166; ACT domain-containing protein	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
K09157; uncharacterized protein	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
K09775; uncharacterized protein	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
manA, MPI; mannose-6-phosphate isomerase [EC:5.3.1.8]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
ME2, sfcA, maeA; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
msmX, msmK, malK, sugC, ggtA, msiK; multiple sugar transport system ATP-binding protein	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
nagC; N-acetylglucosamine repressor	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
nuoE; NADH-quinone oxidoreductase subunit E [EC:1.6.5.3]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
nuoG; NADH-quinone oxidoreductase subunit G [EC:1.6.5.3]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
patA; aminotransferase [EC:2.6.1.-]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
pct; propionate CoA-transferase [EC:2.8.3.1]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
pdxK, pdxY; pyridoxine kinase [EC:2.7.1.35]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
phoB1, phoP; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
phoH2; PhoH-like ATPase	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
phoU; phosphate transport system protein	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
pstA; phosphate transport system permease protein	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
pstB; phosphate transport system ATP-binding protein [EC:3.6.3.27]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
pstS; phosphate transport system substrate-binding protein	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
PTS-Dgl-EIIC, gamP; PTS system, D-glucosamine-specific IIC component	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
PTS-Scr-EIIC, scrA, sacP, sacX, ptsS; PTS system, sucrose-specific IIC component	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
RP-S1, rpsA; small subunit ribosomal protein S1	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
rph; ribonuclease PH [EC:2.7.7.56]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
TC.NCS2; nucleobase:cation symporter-2, NCS2 family	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
udk, UCK; uridine kinase [EC:2.7.1.48]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
virK; uncharacterized protein	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22]	0.44937	0.17057	0.37308	1.70922	0.16216	65	0.50269	6.64877	0.26738	93	0.31271	-0.41448	144.100	0.67914	0.69660
ABC.SN.A; NitT/TauT family transport system ATP-binding protein	0.42966	0.11733	0.50857	1.74337	0.16377	65	0.37450	2.49129	0.16367	93	0.23154	0.57905	150.941	0.56342	0.60499
parA, soj; chromosome partitioning protein	0.42966	0.11733	0.50857	1.74337	0.16377	65	0.37450	2.49129	0.16367	93	0.23154	0.57905	150.941	0.56342	0.60499
ssuB; sulfonate transport system ATP-binding protein [EC:3.6.3.-]	0.42966	0.11733	0.50857	1.74337	0.16377	65	0.37450	2.49129	0.16367	93	0.23154	0.57905	150.941	0.56342	0.60499
mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-]	0.40338	0.11577	0.68923	4.05365	0.24973	65	0.20358	0.69588	0.08650	93	0.26428	1.83759	79.483	0.06986	0.11932
mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC	0.40338	0.11577	0.68923	4.05365	0.24973	65	0.20358	0.69588	0.08650	93	0.26428	1.83759	79.483	0.06986	0.11932
pezT; UDP-N-acetylglucosamine kinase [EC:2.7.1.176]	0.40338	0.11577	0.68923	4.05365	0.24973	65	0.20358	0.69588	0.08650	93	0.26428	1.83759	79.483	0.06986	0.11932
cysE; serine O-acetyltransferase [EC:2.3.1.30]	0.36962	0.16316	0.32385	1.18548	0.13505	65	0.40161	6.35035	0.26131	93	0.29415	-0.26438	133.970	0.79189	0.80823
DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]	0.36962	0.16316	0.32385	1.18548	0.13505	65	0.40161	6.35035	0.26131	93	0.29415	-0.26438	133.970	0.79189	0.80823
E4.3.1.15; diaminopropionate ammonia-lyase [EC:4.3.1.15]	0.36962	0.16316	0.32385	1.18548	0.13505	65	0.40161	6.35035	0.26131	93	0.29415	-0.26438	133.970	0.79189	0.80823
pdxA; 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262]	0.36962	0.16316	0.32385	1.18548	0.13505	65	0.40161	6.35035	0.26131	93	0.29415	-0.26438	133.970	0.79189	0.80823
thrB1; homoserine kinase [EC:2.7.1.39]	0.36962	0.16316	0.32385	1.18548	0.13505	65	0.40161	6.35035	0.26131	93	0.29415	-0.26438	133.970	0.79189	0.80823
mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	0.35570	0.08414	0.54974	1.93803	0.17267	65	0.22007	0.51532	0.07444	93	0.18803	1.75326	87.887	0.08304	0.11932
res; type III restriction enzyme [EC:3.1.21.5]	0.35570	0.08414	0.54974	1.93803	0.17267	65	0.22007	0.51532	0.07444	93	0.18803	1.75326	87.887	0.08304	0.11932
ABC.SN.P; NitT/TauT family transport system permease protein	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
ABC.SN.S; NitT/TauT family transport system substrate-binding protein	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
dinB; DNA polymerase IV [EC:2.7.7.7]	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
E1.1.1.3; homoserine dehydrogenase [EC:1.1.1.3]	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42]	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
E3.5.1.81; N-acyl-D-amino-acid deacylase [EC:3.5.1.81]	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
K07491; putative transposase	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
K07727; putative transcriptional regulator	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
lysC; aspartate kinase [EC:2.7.2.4]	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
metF, MTHFR; methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4]	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
rpoN; RNA polymerase sigma-54 factor	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
ssuA; sulfonate transport system substrate-binding protein	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
ssuC; sulfonate transport system permease protein	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
TC.APA; basic amino acid/polyamine antiporter, APA family	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
thrC; threonine synthase [EC:4.2.3.1]	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-]	0.34322	0.10496	0.36088	0.96461	0.12182	65	0.33088	2.29921	0.15723	93	0.19890	0.15084	155.207	0.88029	0.88387
ABC.SP.A; putative spermidine/putrescine transport system ATP-binding protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
ABC.SP.P; putative spermidine/putrescine transport system permease protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
ABC.SP.P1; putative spermidine/putrescine transport system permease protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
ABC.SP.S; putative spermidine/putrescine transport system substrate-binding protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
ade; adenine deaminase [EC:3.5.4.2]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
ampS, pepS, ampT; aminopeptidase [EC:3.4.11.-]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
comB; 2-phosphosulfolactate phosphatase [EC:3.1.3.71]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
coxS; aerobic carbon-monoxide dehydrogenase small subunit [EC:1.2.5.3]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
cpg; glutamate carboxypeptidase [EC:3.4.17.11]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
croR; 3-hydroxybutyryl-CoA dehydratase [EC:4.2.1.55]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
cynT, can; carbonic anhydrase [EC:4.2.1.1]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
cysZ; CysZ protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
deoB; phosphopentomutase [EC:5.4.2.7]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
dnaC; DNA replication protein DnaC	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
DPYS, dht, hydA; dihydropyrimidinase [EC:3.5.2.2]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
E2.7.1.4, scrK; fructokinase [EC:2.7.1.4]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
E3.2.1.86B, bglA; 6-phospho-beta-glucosidase [EC:3.2.1.86]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
elaA; ElaA protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
feoA; ferrous iron transport protein A	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
feoB; ferrous iron transport protein B	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
glvA; maltose-6’-phosphate glucosidase [EC:3.2.1.122]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
hdrA2; heterodisulfide reductase subunit A2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
hdrB2; heterodisulfide reductase subunit B2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
hdrC2; heterodisulfide reductase subunit C2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
hipO; hippurate hydrolase [EC:3.5.1.32]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
hndA; NADP-reducing hydrogenase subunit HndA [EC:1.12.1.3]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
hndC; NADP-reducing hydrogenase subunit HndC [EC:1.12.1.3]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
hndD; NADP-reducing hydrogenase subunit HndD [EC:1.12.1.3]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
hslU; ATP-dependent HslUV protease ATP-binding subunit HslU	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
hslV, clpQ; ATP-dependent HslUV protease, peptidase subunit HslV [EC:3.4.25.2]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
K01138; uncharacterized sulfatase [EC:3.1.6.-]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
K07025; putative hydrolase of the HAD superfamily	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
K07040; uncharacterized protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
K07098; uncharacterized protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
K09858; SEC-C motif domain protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
kduD; 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase [EC:1.1.1.127]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
kduI; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase [EC:5.3.1.17]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
lysA; diaminopimelate decarboxylase [EC:4.1.1.20]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
mal; methylaspartate ammonia-lyase [EC:4.3.1.2]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
mgsA; methylglyoxal synthase [EC:4.2.3.3]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
moaA, CNX2; GTP 3’,8-cyclase [EC:4.1.99.22]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
moaC, CNX3; cyclic pyranopterin monophosphate synthase [EC:4.6.1.17]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
modA; molybdate transport system substrate-binding protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
modB; molybdate transport system permease protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
moxR; MoxR-like ATPase [EC:3.6.3.-]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
nfo; deoxyribonuclease IV [EC:3.1.21.2]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
nirA; ferredoxin-nitrite reductase [EC:1.7.7.1]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
nuoF; NADH-quinone oxidoreductase subunit F [EC:1.6.5.3]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
pdhR; GntR family transcriptional regulator, transcriptional repressor for pyruvate dehydrogenase complex	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
pdxT, pdx2; 5’-phosphate synthase pdxT subunit [EC:4.3.3.6]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
pheA; chorismate mutase / prephenate dehydratase [EC:5.4.99.5 4.2.1.51]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
porA; pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
porG; pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
proB; glutamate 5-kinase [EC:2.7.2.11]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
PTS-Cel-EIIA, celC, chbA; PTS system, cellobiose-specific IIA component [EC:2.7.1.196 2.7.1.205]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
PTS-Cel-EIIB, celA, chbB; PTS system, cellobiose-specific IIB component [EC:2.7.1.196 2.7.1.205]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
PTS-Cel-EIIC, celB, chbC; PTS system, cellobiose-specific IIC component	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
pyrG, CTPS; CTP synthase [EC:6.3.4.2]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
rbsA; ribose transport system ATP-binding protein [EC:3.6.3.17]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
rbsB; ribose transport system substrate-binding protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
rbsC; ribose transport system permease protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
rbsD; D-ribose pyranase [EC:5.4.99.62]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
rbsK, RBKS; ribokinase [EC:2.7.1.15]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
rlmA1; 23S rRNA (guanine745-N1)-methyltransferase [EC:2.1.1.187]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
rpoE; DNA-directed RNA polymerase subunit delta	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
sdhA, frdA; succinate dehydrogenase / fumarate reductase, flavoprotein subunit [EC:1.3.5.1 1.3.5.4]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
selA; L-seryl-tRNA(Ser) seleniumtransferase [EC:2.9.1.1]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
selB, EEFSEC; selenocysteine-specific elongation factor	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
selD, SEPHS; selenide, water dikinase [EC:2.7.9.3]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
selU; tRNA 2-selenouridine synthase [EC:2.9.1.-]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
sfsA; sugar fermentation stimulation protein A	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
spmA; spore maturation protein A	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
TC.ZIP, zupT, ZRT3, ZIP2; zinc transporter, ZIP family	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
thiB, tbpA; thiamine transport system substrate-binding protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
thiP; thiamine transport system permease protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
ubiB, aarF; ubiquinone biosynthesis protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
urdA; urocanate reductase [EC:1.3.99.33]	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
yabN; tetrapyrrole methylase family protein / MazG family protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
yaeR; glyoxylase I family protein	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
ycdX; putative hydrolase	0.30802	0.10508	0.41026	2.49920	0.19608	65	0.23656	1.22604	0.11482	93	0.22723	0.76442	106.687	0.44630	0.48091
asrA; anaerobic sulfite reductase subunit A	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.16835
asrB; anaerobic sulfite reductase subunit B	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.16835
asrC; anaerobic sulfite reductase subunit C	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.16835
capD; UDP-glucose 4-epimerase [EC:5.1.3.2]	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.16835
E2.2.1.6S, ilvH, ilvN; acetolactate synthase I/III small subunit [EC:2.2.1.6]	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.16835
ilvC; ketol-acid reductoisomerase [EC:1.1.1.86]	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.16835
ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.16835
K07089; uncharacterized protein	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.16835
leuC, IPMI-L; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.16835
leuD, IPMI-S; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.16835
metY; O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49]	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.16835
tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.16835
TC.BAT1; bacterial/archaeal transporter family protein	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.16835
wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14]	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.16835
xerC; integrase/recombinase XerC	0.25485	0.06389	0.37744	1.02806	0.12576	65	0.16918	0.36742	0.06286	93	0.14060	1.48127	95.808	0.14182	0.16835
ARSC2, arsC; arsenate reductase [EC:1.20.4.1]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
barA, gacS, varS; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
crcB, FEX; fluoride exporter	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
csm1, cas10; CRISPR-associated protein Csm1	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
csm3; CRISPR-associated protein Csm3	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
csm4; CRISPR-associated protein Csm4	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
cusR, copR, silR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
cysI; sulfite reductase (NADPH) hemoprotein beta-component [EC:1.8.1.2]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
DOPA; 4,5-DOPA dioxygenase extradiol [EC:1.13.11.-]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
E2.6.1.-E, patB; aminotransferase [EC:2.6.1.-]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
E3.1.21.4; type II restriction enzyme [EC:3.1.21.4]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
FLOT; flotillin	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
K06905; uncharacterized protein	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
K06906; uncharacterized protein	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
K06907; uncharacterized protein	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
K06908; uncharacterized protein	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
K07126; uncharacterized protein	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
K09935; uncharacterized protein	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
K15024; putative phosphotransacetylase [EC:2.3.1.8]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
leuB, IMDH; 3-isopropylmalate dehydrogenase [EC:1.1.1.85]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
metA; homoserine O-succinyltransferase/O-acetyltransferase [EC:2.3.1.46 2.3.1.31]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
oraE; D-ornithine 4,5-aminomutase subunit beta [EC:5.4.3.5]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
oraS; D-ornithine 4,5-aminomutase subunit alpha [EC:5.4.3.5]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
pduC; propanediol dehydratase large subunit [EC:4.2.1.28]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
pduD; propanediol dehydratase medium subunit [EC:4.2.1.28]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
pduE; propanediol dehydratase small subunit [EC:4.2.1.28]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
pduP; propionaldehyde dehydrogenase [EC:1.2.1.87]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
pphA; serine/threonine protein phosphatase 1 [EC:3.1.3.16]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
racD; aspartate racemase [EC:5.1.1.13]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
rocR; arginine utilization regulatory protein	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.22.4]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
secB; preprotein translocase subunit SecB	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
sir; sulfite reductase (ferredoxin) [EC:1.8.7.1]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
topB; DNA topoisomerase III [EC:5.99.1.2]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
trbL; type IV secretion system protein TrbL	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
virB10, lvhB10; type IV secretion system protein VirB10	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
virB11, lvhB11; type IV secretion system protein VirB11	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
virB4, lvhB4; type IV secretion system protein VirB4	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
virB5, lvhB5; type IV secretion system protein VirB5	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
virB9, lvhB9; type IV secretion system protein VirB9	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
virD4, lvhD4; type IV secretion system protein VirD4	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
wbjC; UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase [EC:1.1.1.367]	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
xtmB; phage terminase large subunit	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932
yefM; antitoxin YefM	0.20169	0.05789	0.34462	1.01341	0.12486	65	0.10179	0.17397	0.04325	93	0.13214	1.83759	79.483	0.06986	0.11932

plot.dat <- tb.ra %>%
  arrange(p) %>%
  slice_head(n=50)%>%
  mutate(
    description = fct_reorder(description, `Overall Mean`),
    description = factor(description, levels = levels(description), ordered=T)
  ) %>%
  arrange(description) %>%
  mutate(
    id = 1:n(),
    step = ifelse(id%%2 == 0, 1, 0),
    Mean_diff = `Tumor Mean` - `Non-Tumor Mean`,
    Mean_diff_ll = Mean_diff - qt(0.975, df)*SEpooled,
    Mean_diff_ul = Mean_diff + qt(0.975, df)*SEpooled
  ) %>%
  pivot_longer(
    cols=contains("Mean"),
    names_to = "group",
    values_to = "mean"
  )



p1.d <- plot.dat %>%
  filter(group %in% c("Tumor Mean","Non-Tumor Mean")) %>%
  mutate(
    group = ifelse(group == "Tumor Mean", "Tumor", "Non-Tumor"),
    col = ifelse(step == 1, "grey90", "white"),
    h=1, w=Inf
    
  )
p1 <- ggplot()+
  geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_bar(data=p1.d,
             aes(x=mean, y=description,
                 group=group, color=group,
                 fill=group),
             stat="identity",position = "dodge",
             alpha = 1)+
    labs(x="Mean Abundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      plot.margin = unit(c(1,0,1,1), "lines")
    )

p2.d <- plot.dat %>%
  filter(group %in% c("Mean_diff", "Mean_diff_ll", "Mean_diff_ul")) %>%
  pivot_wider(
    names_from = group,
    values_from = mean
  ) %>%
  mutate(
    group = ifelse(Mean_diff > 0, "Tumor", "Non-Tumor"),
    p = sprintf("%.3f", round(p,3)),
    ll = min(Mean_diff_ll)-0.01,
    ul = max(Mean_diff_ul)+0.01
  )
p2<-ggplot(p2.d, aes(x=Mean_diff, y=description))+
    geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_vline(xintercept = 0, linetype="dashed", alpha=0.5)+
    geom_segment(aes(x=Mean_diff_ll, y=description, xend=Mean_diff_ul, yend=description))+
    geom_point(aes(fill=group, color=group))+
    geom_text(aes(label=p, x=unique(ul)+0.1))+
    coord_cartesian(xlim = c(unique(p2.d$ll), unique(p2.d$ul)),
                    clip = 'off') +
    annotate("text", x=unique(p2.d$ul)+0.2,y = 25,
             angle=90,
             label="p-value (uncorrected)")+
    labs(x="Mean Difference in Abundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      axis.title.y = element_blank(),
      axis.text.y = element_blank(),
      axis.line.y = element_blank(),
      axis.ticks.y = element_blank(),
      plot.margin = unit(c(1,4,1,0), "lines")
    )

# plot
p1 + p2 +
  plot_annotation(title="Stratefied KO Data - Fusobacterium nucleatum: First 50 descriptions with lowest p-value (uncorrected)")

Modeling Difference between Tumor and Non-Tumor

For the modeling, we used a generalized linear mixed model (GLMM).

First, we looked at the biserial correlation between the abundance of each description and the tumor status.

tb <- mydata %>%
  group_by(description)%>%
  summarise(
    r = cor(tumor, Abundance)
  ) %>%
  mutate(
    M=mean(r)
  )

ggplot(tb, aes(x=r))+
  geom_density()+
  geom_vline(aes(xintercept = M))+
  labs(x="Biserial Correlation",title="Relationship between description abundance and tumor (tumor vs. non-tumor)")+
  theme(panel.grid = element_blank())

Next, we need the data to be on an interpretable scale. First, let’s use the raw abundance like scale.

p <- ggplot(mydata, aes(x=Abundance))+
  geom_density()
p

mydata <- mydata %>%
  mutate(Abundance.dich=ifelse(Abundance==0, 0, 1))
table(mydata$Abundance.dich)

     0      1 
122745  72701 

Let’s first run models by description so that we can avoid the nesting issue initially. We will come back to this to conduct the final model (it will be more powerful).

DESCRIPTIONS <- unique(mydata$description)
i<-1
dat0 <- mydata %>% filter(description==DESCRIPTIONS[i])

# quasipossion (approximately negative binom) give an approx. answer.
fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
summary(fit0)

Call:
glm(formula = Abundance ~ 1 + tumor, family = quasipoisson(link = "log"), 
    data = dat0)

Deviance Residuals: 
   Min      1Q  Median      3Q     Max  
 -3.43   -2.84   -1.96   -1.53   18.85  

Coefficients:
            Estimate Std. Error t value Pr(>|t|)  
(Intercept)    0.655      0.457    1.44    0.153  
tumor          1.115      0.553    2.02    0.046 *
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for quasipoisson family taken to be 37.333)

    Null deviance: 2461.1  on 157  degrees of freedom
Residual deviance: 2295.6  on 156  degrees of freedom
AIC: NA

Number of Fisher Scoring iterations: 7

NExt, let’s model the percent relative abundance. This will allow us to make inference about the difference average relative abundance. Which is a simpler interpretation than trying to model differences in the log relative abundance which will need to be interpreted as the multiplicative relative change.

results.out <- as.data.frame(matrix(ncol=4, nrow=length(DESCRIPTIONS)))
colnames(results.out) <- c("description", "Est", "SE", "p")
#results.out$description <-DESCRIPTIONS

i <- 1
for(i in 1:length(DESCRIPTIONS)){
#for(i in 1:5){ 
  dat0 <- mydata %>%
    filter(description == DESCRIPTIONS[i])
  fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
  fit.sum <- summary(fit0)
  results.out[i, 1] <- DESCRIPTIONS[i]
  results.out[i, 2:4] <- fit.sum$coefficients[2, c(1,2,4)]
}

results.out$fdr_p <- p.adjust(results.out$p, method="fdr")

kable(results.out, format="html", digits=3) %>%
  kable_styling(full_width = T)%>%
  scroll_box(width="100%", height="600px")

description	Est	SE	p	fdr_p
AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]	1.115	0.553	0.046	0.058
ABC-2.A; ABC-2 type transport system ATP-binding protein	1.111	0.570	0.053	0.065
ABC-2.P; ABC-2 type transport system permease protein	1.155	0.607	0.059	0.072
ABC.CD.A; putative ABC transport system ATP-binding protein	1.185	0.571	0.040	0.058
ABC.CD.P; putative ABC transport system permease protein	1.223	0.582	0.037	0.058
ABC.FEV.A; iron complex transport system ATP-binding protein [EC:3.6.3.34]	1.206	0.582	0.040	0.058
ABC.FEV.P; iron complex transport system permease protein	1.225	0.584	0.038	0.058
ABC.FEV.S; iron complex transport system substrate-binding protein	1.240	0.596	0.039	0.058
ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:3.6.3.21]	0.954	0.514	0.065	0.080
ABC.PA.P; polar amino acid transport system permease protein	0.963	0.504	0.058	0.071
ABC.PA.S; polar amino acid transport system substrate-binding protein	1.013	0.519	0.053	0.065
ABC.PE.A; peptide/nickel transport system ATP-binding protein	1.223	0.582	0.037	0.058
ABC.PE.A1; peptide/nickel transport system ATP-binding protein	1.246	0.592	0.037	0.058
ABC.PE.P; peptide/nickel transport system permease protein	1.240	0.593	0.038	0.058
ABC.PE.P1; peptide/nickel transport system permease protein	1.240	0.593	0.038	0.058
ABC.PE.S; peptide/nickel transport system substrate-binding protein	1.098	0.552	0.048	0.062
ABC.SN.A; NitT/TauT family transport system ATP-binding protein	0.306	0.561	0.586	0.629
ABC.SN.P; NitT/TauT family transport system permease protein	0.087	0.625	0.890	0.893
ABC.SN.S; NitT/TauT family transport system substrate-binding protein	0.087	0.625	0.890	0.893
ABC.SP.A; putative spermidine/putrescine transport system ATP-binding protein	0.551	0.679	0.419	0.451
ABC.SP.P; putative spermidine/putrescine transport system permease protein	0.551	0.679	0.419	0.451
ABC.SP.P1; putative spermidine/putrescine transport system permease protein	0.551	0.679	0.419	0.451
ABC.SP.S; putative spermidine/putrescine transport system substrate-binding protein	0.551	0.679	0.419	0.451
ABC.SS.A; simple sugar transport system ATP-binding protein [EC:3.6.3.17]	1.115	0.553	0.046	0.058
ABC.SS.P; simple sugar transport system permease protein	1.115	0.553	0.046	0.058
ABC.X4.A; putative ABC transport system ATP-binding protein	1.119	0.539	0.040	0.058
ABC.X4.P; putative ABC transport system permease protein	1.119	0.539	0.040	0.058
ABC.X4.S; putative ABC transport system substrate-binding protein	0.979	0.537	0.070	0.085
ABC.ZM.S; zinc/manganese transport system substrate-binding protein	1.352	0.629	0.033	0.058
ABCB-BAC; ATP-binding cassette, subfamily B, bacterial	1.144	0.562	0.044	0.058
ABCC-BAC; ATP-binding cassette, subfamily C, bacterial	1.352	0.629	0.033	0.058
ABCF3; ATP-binding cassette, subfamily F, member 3	1.115	0.553	0.046	0.058
abfD; 4-hydroxybutyryl-CoA dehydratase / vinylacetyl-CoA-Delta-isomerase [EC:4.2.1.120 5.3.3.3]	-1.604	1.840	0.385	0.450
abgT; aminobenzoyl-glutamate transport protein	1.113	0.561	0.049	0.062
ACADS, bcd; butyryl-CoA dehydrogenase [EC:1.3.8.1]	1.184	0.577	0.042	0.058
accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]	1.115	0.553	0.046	0.058
accB, bccP; acetyl-CoA carboxylase biotin carboxyl carrier protein	0.001	0.653	0.999	0.999
accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	-0.298	0.779	0.702	0.720
accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]	1.115	0.553	0.046	0.058
ackA; acetate kinase [EC:2.7.2.1]	1.115	0.553	0.046	0.058
acpP; acyl carrier protein	1.115	0.553	0.046	0.058
acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7]	1.115	0.553	0.046	0.058
ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]	1.184	0.577	0.042	0.058
ade; adenine deaminase [EC:3.5.4.2]	0.551	0.679	0.419	0.451
adk, AK; adenylate kinase [EC:2.7.4.3]	1.115	0.553	0.046	0.058
afuA, fbpA; iron(III) transport system substrate-binding protein	1.198	0.557	0.033	0.058
afuB, fbpB; iron(III) transport system permease protein	1.198	0.565	0.036	0.058
afuC, fbpC; iron(III) transport system ATP-binding protein [EC:3.6.3.30]	1.198	0.565	0.036	0.058
ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]	1.352	0.629	0.033	0.058
algI; alginate O-acetyltransferase complex protein AlgI	1.359	0.653	0.039	0.058
alr; alanine racemase [EC:5.1.1.1]	1.115	0.553	0.046	0.058
amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	1.088	0.505	0.033	0.058
ampS, pepS, ampT; aminopeptidase [EC:3.4.11.-]	0.551	0.679	0.419	0.451
apbE; FAD:protein FMN transferase [EC:2.7.1.180]	1.115	0.553	0.046	0.058
APEH; acylaminoacyl-peptidase [EC:3.4.19.1]	1.115	0.553	0.046	0.058
APRT, apt; adenine phosphoribosyltransferase [EC:2.4.2.7]	1.223	0.582	0.037	0.058
argG, ASS1; argininosuccinate synthase [EC:6.3.4.5]	-0.298	0.779	0.702	0.720
argH, ASL; argininosuccinate lyase [EC:4.3.2.1]	-0.298	0.779	0.702	0.720
aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]	1.115	0.553	0.046	0.058
AROA2, aroA; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	1.115	0.553	0.046	0.058
aroC; chorismate synthase [EC:4.2.3.5]	1.115	0.553	0.046	0.058
aroE; shikimate dehydrogenase [EC:1.1.1.25]	1.286	0.613	0.038	0.058
aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10]	1.115	0.553	0.046	0.058
arsA, ASNA1, GET3; arsenite/tail-anchored protein-transporting ATPase [EC:3.6.3.16 3.6.3.-]	1.359	0.653	0.039	0.058
ARSC1, arsC; arsenate reductase [EC:1.20.4.1]	1.115	0.553	0.046	0.058
ARSC2, arsC; arsenate reductase [EC:1.20.4.1]	1.219	0.577	0.036	0.058
arsR; ArsR family transcriptional regulator, arsenate/arsenite/antimonite-responsive transcriptional repressor	1.119	0.539	0.040	0.058
asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	0.087	0.625	0.890	0.893
asnA; aspartate–ammonia ligase [EC:6.3.1.1]	1.115	0.553	0.046	0.058
aspA; aspartate ammonia-lyase [EC:4.3.1.1]	-0.298	0.779	0.702	0.720
aspB; aspartate aminotransferase [EC:2.6.1.1]	1.115	0.553	0.046	0.058
aspS; aspartyl-tRNA synthetase [EC:6.1.1.12]	1.115	0.553	0.046	0.058
asrA; anaerobic sulfite reductase subunit A	0.802	0.500	0.111	0.131
asrB; anaerobic sulfite reductase subunit B	0.802	0.500	0.111	0.131
asrC; anaerobic sulfite reductase subunit C	0.802	0.500	0.111	0.131
atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]	1.223	0.591	0.040	0.058
atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]	1.223	0.591	0.040	0.058
atoE; short-chain fatty acids transporter	1.115	0.553	0.046	0.058
ATPF0A, atpB; F-type H+-transporting ATPase subunit a	1.115	0.553	0.046	0.058
ATPF0B, atpF; F-type H+-transporting ATPase subunit b	1.115	0.553	0.046	0.058
ATPF0C, atpE; F-type H+-transporting ATPase subunit c	1.115	0.553	0.046	0.058
ATPF1A, atpA; F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14]	1.115	0.553	0.046	0.058
ATPF1B, atpD; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14]	1.115	0.553	0.046	0.058
ATPF1D, atpH; F-type H+-transporting ATPase subunit delta	1.115	0.553	0.046	0.058
ATPF1E, atpC; F-type H+-transporting ATPase subunit epsilon	1.115	0.553	0.046	0.058
ATPF1G, atpG; F-type H+-transporting ATPase subunit gamma	1.115	0.553	0.046	0.058
atpI; ATP synthase protein I	1.352	0.629	0.033	0.058
ATPVA, ntpA, atpA; V/A-type H+/Na+-transporting ATPase subunit A [EC:3.6.3.14 3.6.3.15]	1.158	0.588	0.051	0.063
ATPVB, ntpB, atpB; V/A-type H+/Na+-transporting ATPase subunit B	1.158	0.588	0.051	0.063
ATPVC, ntpC, atpC; V/A-type H+/Na+-transporting ATPase subunit C	1.158	0.588	0.051	0.063
ATPVD, ntpD, atpD; V/A-type H+/Na+-transporting ATPase subunit D	1.161	0.572	0.044	0.058
ATPVE, ntpE, atpE; V/A-type H+/Na+-transporting ATPase subunit E	1.158	0.588	0.051	0.063
ATPVF, ntpF, atpF; V/A-type H+/Na+-transporting ATPase subunit F	1.158	0.588	0.051	0.063
ATPVG, ahaH, atpH; V/A-type H+/Na+-transporting ATPase subunit G/H	1.352	0.629	0.033	0.058
ATPVI, ntpI, atpI; V/A-type H+/Na+-transporting ATPase subunit I	1.158	0.588	0.051	0.063
ATPVK, ntpK, atpK; V/A-type H+/Na+-transporting ATPase subunit K	1.158	0.588	0.051	0.063
bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]	1.115	0.553	0.046	0.058
barA, gacS, varS; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]	1.219	0.577	0.036	0.058
bax; Bax protein	1.115	0.553	0.046	0.058
bdhAB; butanol dehydrogenase [EC:1.1.1.-]	1.197	0.573	0.038	0.058
bigA; putative surface-exposed virulence protein	1.343	0.600	0.027	0.058
bioA; adenosylmethionine—8-amino-7-oxononanoate aminotransferase [EC:2.6.1.62]	1.115	0.553	0.046	0.058
bioB; biotin synthase [EC:2.8.1.6]	0.945	0.526	0.074	0.090
bioC; malonyl-CoA O-methyltransferase [EC:2.1.1.197]	1.115	0.553	0.046	0.058
bioD; dethiobiotin synthetase [EC:6.3.3.3]	1.115	0.553	0.046	0.058
bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47]	1.115	0.553	0.046	0.058
bioG; pimeloyl-[acyl-carrier protein] methyl ester esterase [EC:3.1.1.85]	1.115	0.553	0.046	0.058
bioY; biotin transport system substrate-specific component	1.352	0.629	0.033	0.058
birA; BirA family transcriptional regulator, biotin operon repressor / biotin—[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	1.115	0.553	0.046	0.058
bshA; L-malate glycosyltransferase [EC:2.4.1.-]	1.136	0.569	0.048	0.061
capD; UDP-glucose 4-epimerase [EC:5.1.3.2]	0.802	0.500	0.111	0.131
carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]	1.115	0.553	0.046	0.058
carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]	1.115	0.553	0.046	0.058
CARP, pepA; leucyl aminopeptidase [EC:3.4.11.1]	1.115	0.553	0.046	0.058
CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16]	1.115	0.553	0.046	0.058
cas1; CRISP-associated protein Cas1	1.115	0.553	0.046	0.058
cas2; CRISPR-associated protein Cas2	1.115	0.553	0.046	0.058
cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 3.6.4.-]	1.292	0.606	0.034	0.058
cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]	1.292	0.606	0.034	0.058
cas5t; CRISPR-associated protein Cas5t	1.359	0.653	0.039	0.058
cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]	1.292	0.606	0.034	0.058
cat2, abfT; 4-hydroxybutyrate CoA-transferase [EC:2.8.3.-]	1.115	0.553	0.046	0.058
cbiB, cobD; adenosylcobinamide-phosphate synthase [EC:6.3.1.10]	1.115	0.553	0.046	0.058
cbiD; cobalt-precorrin-5B (C1)-methyltransferase [EC:2.1.1.195]	1.115	0.553	0.046	0.058
cbiE; cobalt-precorrin-7 (C5)-methyltransferase [EC:2.1.1.289]	1.115	0.553	0.046	0.058
cbiG; cobalt-precorrin 5A hydrolase [EC:3.7.1.12]	1.115	0.553	0.046	0.058
cbiK; sirohydrochlorin cobaltochelatase [EC:4.99.1.3]	1.115	0.553	0.046	0.058
cbiN; cobalt/nickel transport protein	1.250	0.603	0.040	0.058
cbiT; cobalt-precorrin-6B (C15)-methyltransferase [EC:2.1.1.196]	1.115	0.553	0.046	0.058
cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]	1.115	0.553	0.046	0.058
ccdA; cytochrome c-type biogenesis protein	1.223	0.582	0.037	0.058
cdd, CDA; cytidine deaminase [EC:3.5.4.5]	-0.298	0.779	0.702	0.720
CHO1, pssA; CDP-diacylglycerol—serine O-phosphatidyltransferase [EC:2.7.8.8]	1.115	0.553	0.046	0.058
chrA; chromate transporter	1.115	0.553	0.046	0.058
cidA; holin-like protein	1.115	0.553	0.046	0.058
citC; [citrate (pro-3S)-lyase] ligase [EC:6.2.1.22]	1.289	0.586	0.029	0.058
citD; citrate lyase subunit gamma (acyl carrier protein)	1.115	0.553	0.046	0.058
citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34]	1.115	0.553	0.046	0.058
citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10]	1.115	0.553	0.046	0.058
citG; triphosphoribosyl-dephospho-CoA synthase [EC:2.4.2.52]	1.352	0.629	0.033	0.058
citX; holo-ACP synthase [EC:2.7.7.61]	1.352	0.629	0.033	0.058
clpB; ATP-dependent Clp protease ATP-binding subunit ClpB	1.115	0.553	0.046	0.058
clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]	1.115	0.553	0.046	0.058
clpX, CLPX; ATP-dependent Clp protease ATP-binding subunit ClpX	1.115	0.553	0.046	0.058
clsA_B; cardiolipin synthase A/B [EC:2.7.8.-]	1.115	0.553	0.046	0.058
cmk; CMP/dCMP kinase [EC:2.7.4.25]	1.115	0.553	0.046	0.058
cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-]	1.359	0.653	0.039	0.058
CNP; 2’,3’-cyclic-nucleotide 3’-phosphodiesterase [EC:3.1.4.37]	1.352	0.629	0.033	0.058
coaBC, dfp; phosphopantothenoylcysteine decarboxylase / phosphopantothenate—cysteine ligase [EC:4.1.1.36 6.3.2.5]	1.115	0.553	0.046	0.058
coaE; dephospho-CoA kinase [EC:2.7.1.24]	1.115	0.553	0.046	0.058
coaX; type III pantothenate kinase [EC:2.7.1.33]	1.115	0.553	0.046	0.058
cobA-hemD; uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]	1.115	0.553	0.046	0.058
cobA, btuR; cob(I)alamin adenosyltransferase [EC:2.5.1.17]	1.115	0.553	0.046	0.058
cobB-cbiA; cobyrinic acid a,c-diamide synthase [EC:6.3.5.9 6.3.5.11]	1.115	0.553	0.046	0.058
cobC, phpB; alpha-ribazole phosphatase [EC:3.1.3.73]	1.115	0.553	0.046	0.058
cobD; threonine-phosphate decarboxylase [EC:4.1.1.81]	1.115	0.553	0.046	0.058
cobH-cbiC; precorrin-8X/cobalt-precorrin-8 methylmutase [EC:5.4.99.61 5.4.99.60]	1.115	0.553	0.046	0.058
cobI-cbiL; precorrin-2/cobalt-factor-2 C20-methyltransferase [EC:2.1.1.130 2.1.1.151]	1.115	0.553	0.046	0.058
cobK-cbiJ; precorrin-6A/cobalt-precorrin-6A reductase [EC:1.3.1.54 1.3.1.106]	1.115	0.553	0.046	0.058
cobM, cbiF; precorrin-4/cobalt-precorrin-4 C11-methyltransferase [EC:2.1.1.133 2.1.1.271]	1.115	0.553	0.046	0.058
cobP, cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62]	1.115	0.553	0.046	0.058
cobQ, cbiP; adenosylcobyric acid synthase [EC:6.3.5.10]	1.115	0.553	0.046	0.058
comB; 2-phosphosulfolactate phosphatase [EC:3.1.3.71]	0.551	0.679	0.419	0.451
comEA; competence protein ComEA	1.115	0.553	0.046	0.058
comEB; dCMP deaminase [EC:3.5.4.12]	1.115	0.553	0.046	0.058
comEC; competence protein ComEC	1.115	0.553	0.046	0.058
comFC; competence protein ComFC	1.115	0.553	0.046	0.058
comM; magnesium chelatase family protein	1.115	0.553	0.046	0.058
copA, ATP7; Cu+-exporting ATPase [EC:3.6.3.54]	1.115	0.553	0.046	0.058
corA; magnesium transporter	1.115	0.553	0.046	0.058
coxS; aerobic carbon-monoxide dehydrogenase small subunit [EC:1.2.5.3]	0.551	0.679	0.419	0.451
cpg; glutamate carboxypeptidase [EC:3.4.17.11]	0.551	0.679	0.419	0.451
crcB, FEX; fluoride exporter	1.219	0.577	0.036	0.058
creD; inner membrane protein	1.115	0.553	0.046	0.058
croR; 3-hydroxybutyryl-CoA dehydratase [EC:4.2.1.55]	0.551	0.679	0.419	0.451
crt; enoyl-CoA hydratase [EC:4.2.1.17]	1.115	0.553	0.046	0.058
csm1, cas10; CRISPR-associated protein Csm1	1.219	0.577	0.036	0.058
csm3; CRISPR-associated protein Csm3	1.219	0.577	0.036	0.058
csm4; CRISPR-associated protein Csm4	1.219	0.577	0.036	0.058
cspA; cold shock protein (beta-ribbon, CspA family)	0.945	0.526	0.074	0.090
cst1, cas8a; CRISPR-associated protein Cst1	1.359	0.653	0.039	0.058
cst2, cas7; CRISPR-associated protein Cst2	1.359	0.653	0.039	0.058
ctpC; manganese/zinc-transporting P-type ATPase C [EC:3.6.3.-]	1.289	0.586	0.029	0.058
cusR, copR, silR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR	1.219	0.577	0.036	0.058
cutC; copper homeostasis protein	1.115	0.553	0.046	0.058
cvpA; membrane protein required for colicin V production	1.115	0.553	0.046	0.058
cvrA, nhaP2; cell volume regulation protein A	1.115	0.553	0.046	0.058
cwlK; peptidoglycan LD-endopeptidase CwlK [EC:3.4.-.-]	0.363	0.518	0.484	0.521
cynT, can; carbonic anhydrase [EC:4.2.1.1]	0.551	0.679	0.419	0.451
cysE; serine O-acetyltransferase [EC:2.3.1.30]	-0.215	0.897	0.811	0.827
cysI; sulfite reductase (NADPH) hemoprotein beta-component [EC:1.8.1.2]	1.219	0.577	0.036	0.058
cysK; cysteine synthase A [EC:2.5.1.47]	1.317	0.596	0.029	0.058
cysS1; cysteinyl-tRNA synthetase, unknown class [EC:6.1.1.16]	1.352	0.629	0.033	0.058
cysZ; CysZ protein	0.551	0.679	0.419	0.451
dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]	0.551	0.679	0.419	0.451
dacC, dacA, dacD; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]	1.115	0.553	0.046	0.058
dam; DNA adenine methylase [EC:2.1.1.72]	1.352	0.629	0.033	0.058
dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]	1.072	0.542	0.050	0.063
dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	0.087	0.625	0.890	0.893
dapD; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [EC:2.3.1.117]	-1.604	1.840	0.385	0.450
dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]	1.115	0.553	0.046	0.058
dapF; diaminopimelate epimerase [EC:5.1.1.7]	-0.298	0.779	0.702	0.720
dapH, dapD; tetrahydrodipicolinate N-acetyltransferase [EC:2.3.1.89]	-0.298	0.779	0.702	0.720
dctM; C4-dicarboxylate transporter, DctM subunit	1.359	0.653	0.039	0.058
ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]	1.115	0.553	0.046	0.058
deaD, cshA; ATP-dependent RNA helicase DeaD [EC:3.6.4.13]	1.115	0.553	0.046	0.058
deoB; phosphopentomutase [EC:5.4.2.7]	0.551	0.679	0.419	0.451
deoC, DERA; deoxyribose-phosphate aldolase [EC:4.1.2.4]	-0.298	0.779	0.702	0.720
deoD; purine-nucleoside phosphorylase [EC:2.4.2.1]	1.115	0.553	0.046	0.058
dfx; superoxide reductase [EC:1.15.1.2]	-0.298	0.779	0.702	0.720
dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]	-0.298	0.779	0.702	0.720
dhaK; phosphoenolpyruvate—glycerone phosphotransferase subunit DhaK [EC:2.7.1.121]	1.158	0.588	0.051	0.063
dhaL; phosphoenolpyruvate—glycerone phosphotransferase subunit DhaL [EC:2.7.1.121]	1.158	0.588	0.051	0.063
DHFR, folA; dihydrofolate reductase [EC:1.5.1.3]	1.115	0.553	0.046	0.058
dinB; DNA polymerase IV [EC:2.7.7.7]	0.087	0.625	0.890	0.893
dinG; ATP-dependent DNA helicase DinG [EC:3.6.4.12]	1.115	0.553	0.046	0.058
dinJ; DNA-damage-inducible protein J	1.223	0.591	0.040	0.058
disA; diadenylate cyclase [EC:2.7.7.85]	1.115	0.553	0.046	0.058
DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4]	-1.604	1.840	0.385	0.450
dnaB; replicative DNA helicase [EC:3.6.4.12]	1.115	0.553	0.046	0.058
dnaC; DNA replication protein DnaC	0.551	0.679	0.419	0.451
dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	1.115	0.553	0.046	0.058
dnaG; DNA primase [EC:2.7.7.-]	1.115	0.553	0.046	0.058
dnaJ; molecular chaperone DnaJ	1.115	0.553	0.046	0.058
dnaK, HSPA9; molecular chaperone DnaK	1.115	0.553	0.046	0.058
dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]	1.115	0.553	0.046	0.058
dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]	-0.298	0.779	0.702	0.720
dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]	1.115	0.553	0.046	0.058
DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]	-0.215	0.897	0.811	0.827
DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]	1.158	0.588	0.051	0.063
DOPA; 4,5-DOPA dioxygenase extradiol [EC:1.13.11.-]	1.219	0.577	0.036	0.058
DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83]	1.352	0.629	0.033	0.058
dpo; DNA polymerase bacteriophage-type [EC:2.7.7.7]	1.115	0.553	0.046	0.058
dps; starvation-inducible DNA-binding protein	1.115	0.553	0.046	0.058
DPYS, dht, hydA; dihydropyrimidinase [EC:3.5.2.2]	0.551	0.679	0.419	0.451
dsdA; D-serine dehydratase [EC:4.3.1.18]	1.359	0.653	0.039	0.058
dtd, DTD1; D-tyrosyl-tRNA(Tyr) deacylase [EC:3.1.-.-]	1.115	0.553	0.046	0.058
dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23]	1.115	0.553	0.046	0.058
dxr; 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267]	1.115	0.553	0.046	0.058
dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]	1.136	0.569	0.048	0.061
E1.1.1.3; homoserine dehydrogenase [EC:1.1.1.3]	0.087	0.625	0.890	0.893
E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]	1.115	0.553	0.046	0.058
E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]	1.115	0.553	0.046	0.058
E2.1.1.104; caffeoyl-CoA O-methyltransferase [EC:2.1.1.104]	1.115	0.553	0.046	0.058
E2.1.1.131, cobJ, cbiH; precorrin-3B C17-methyltransferase [EC:2.1.1.131]	1.115	0.553	0.046	0.058
E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	1.115	0.553	0.046	0.058
E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	1.289	0.586	0.029	0.058
E2.2.1.6S, ilvH, ilvN; acetolactate synthase I/III small subunit [EC:2.2.1.6]	0.802	0.500	0.111	0.131
E2.3.1.54, pflD; formate C-acetyltransferase [EC:2.3.1.54]	1.115	0.553	0.046	0.058
E2.3.1.8, pta; phosphate acetyltransferase [EC:2.3.1.8]	1.115	0.553	0.046	0.058
E2.3.1.9, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]	1.115	0.553	0.046	0.058
E2.4.2.21, cobU, cobT; nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21]	1.115	0.553	0.046	0.058
E2.6.1.-E, patB; aminotransferase [EC:2.6.1.-]	1.219	0.577	0.036	0.058
E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42]	0.087	0.625	0.890	0.893
E2.7.1.37; protein kinase [EC:2.7.1.37]	1.289	0.586	0.029	0.058
E2.7.1.4, scrK; fructokinase [EC:2.7.1.4]	0.551	0.679	0.419	0.451
E2.7.1.71, aroK, aroL; shikimate kinase [EC:2.7.1.71]	1.115	0.553	0.046	0.058
E2.7.4.8, gmk; guanylate kinase [EC:2.7.4.8]	1.115	0.553	0.046	0.058
E2.7.7.24, rfbA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]	-0.298	0.779	0.702	0.720
E2.7.7.3A, coaD, kdtB; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]	1.115	0.553	0.046	0.058
E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	1.136	0.569	0.048	0.061
E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	1.115	0.553	0.046	0.058
E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2]	1.115	0.553	0.046	0.058
E3.1.21.4; type II restriction enzyme [EC:3.1.21.4]	1.219	0.577	0.036	0.058
E3.1.3.15B; histidinol-phosphatase (PHP family) [EC:3.1.3.15]	1.115	0.553	0.046	0.058
E3.1.3.41; 4-nitrophenyl phosphatase [EC:3.1.3.41]	1.352	0.629	0.033	0.058
E3.1.3.97; 3’,5’-nucleoside bisphosphate phosphatase [EC:3.1.3.97]	0.001	0.653	0.999	0.999
E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]	1.223	0.582	0.037	0.058
E3.2.1.86B, bglA; 6-phospho-beta-glucosidase [EC:3.2.1.86]	0.551	0.679	0.419	0.451
E3.4.11.-; aminopeptidase [EC:3.4.11.-]	1.115	0.553	0.046	0.058
E3.4.17.19; carboxypeptidase Taq [EC:3.4.17.19]	1.115	0.553	0.046	0.058
E3.4.21.102, prc, ctpA; carboxyl-terminal processing protease [EC:3.4.21.102]	1.115	0.553	0.046	0.058
E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	1.115	0.553	0.046	0.058
E3.5.1.28D, amiD; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	1.289	0.586	0.029	0.058
E3.5.1.81; N-acyl-D-amino-acid deacylase [EC:3.5.1.81]	0.087	0.625	0.890	0.893
E3.6.3.8; Ca2+-transporting ATPase [EC:3.6.3.8]	1.115	0.553	0.046	0.058
E4.1.1.17, ODC1, speC, speF; ornithine decarboxylase [EC:4.1.1.17]	1.289	0.586	0.029	0.058
E4.1.1.49, pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]	1.352	0.629	0.033	0.058
E4.1.3.3, nanA, NPL; N-acetylneuraminate lyase [EC:4.1.3.3]	1.115	0.553	0.046	0.058
E4.1.3.4, HMGCL, hmgL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]	1.359	0.653	0.039	0.058
E4.1.99.2; tyrosine phenol-lyase [EC:4.1.99.2]	1.158	0.588	0.051	0.063
E4.2.1.2AA, fumA; fumarate hydratase subunit alpha [EC:4.2.1.2]	-0.298	0.779	0.702	0.720
E4.2.1.2AB, fumB; fumarate hydratase subunit beta [EC:4.2.1.2]	-0.298	0.779	0.702	0.720
E4.2.1.46, rfbB, rffG; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]	1.115	0.553	0.046	0.058
E4.3.1.15; diaminopropionate ammonia-lyase [EC:4.3.1.15]	-0.215	0.897	0.811	0.827
E4.3.1.17, sdaA, sdaB, tdcG; L-serine dehydratase [EC:4.3.1.17]	1.115	0.553	0.046	0.058
E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	1.119	0.539	0.040	0.058
E4.3.1.4; formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4]	1.355	0.641	0.036	0.058
E4.4.1.11; methionine-gamma-lyase [EC:4.4.1.11]	1.115	0.553	0.046	0.058
E5.2.1.8; peptidylprolyl isomerase [EC:5.2.1.8]	1.319	0.606	0.031	0.058
E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]	1.115	0.553	0.046	0.058
EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17]	1.115	0.553	0.046	0.058
ecfA1; energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-]	1.352	0.629	0.033	0.058
ecfA2; energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-]	1.223	0.591	0.040	0.058
ecfT; energy-coupling factor transport system permease protein	1.115	0.553	0.046	0.058
eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42]	-0.298	0.779	0.702	0.720
efp; elongation factor P	1.115	0.553	0.046	0.058
elaA; ElaA protein	0.551	0.679	0.419	0.451
ENDOG; endonuclease G, mitochondrial	1.359	0.653	0.039	0.058
engA, der; GTPase	1.115	0.553	0.046	0.058
engB; GTP-binding protein	1.115	0.553	0.046	0.058
ENO, eno; enolase [EC:4.2.1.11]	1.115	0.553	0.046	0.058
era, ERAL1; GTPase	1.115	0.553	0.046	0.058
eutA; ethanolamine utilization protein EutA	1.352	0.629	0.033	0.058
eutB; ethanolamine ammonia-lyase large subunit [EC:4.3.1.7]	1.352	0.629	0.033	0.058
eutC; ethanolamine ammonia-lyase small subunit [EC:4.3.1.7]	1.352	0.629	0.033	0.058
eutH; ethanolamine transporter	1.158	0.588	0.051	0.063
eutJ; ethanolamine utilization protein EutJ	1.352	0.629	0.033	0.058
eutL; ethanolamine utilization protein EutL	1.352	0.629	0.033	0.058
eutM; ethanolamine utilization protein EutM	1.352	0.629	0.033	0.058
eutN; ethanolamine utilization protein EutN	1.346	0.609	0.029	0.058
eutP; ethanolamine utilization protein EutP	1.352	0.629	0.033	0.058
eutQ; ethanolamine utilization protein EutQ	1.352	0.629	0.033	0.058
eutS; ethanolamine utilization protein EutS	1.352	0.629	0.033	0.058
eutT; ethanolamine utilization cobalamin adenosyltransferase [EC:2.5.1.17]	1.352	0.629	0.033	0.058
exbB; biopolymer transport protein ExbB	1.115	0.553	0.046	0.058
exbD; biopolymer transport protein ExbD	1.115	0.553	0.046	0.058
fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]	1.115	0.553	0.046	0.058
fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]	1.115	0.553	0.046	0.058
fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]	1.115	0.553	0.046	0.058
fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]	1.223	0.582	0.037	0.058
fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]	1.115	0.553	0.046	0.058
fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]	1.115	0.553	0.046	0.058
fadL; long-chain fatty acid transport protein	1.115	0.553	0.046	0.058
FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]	1.115	0.553	0.046	0.058
FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]	1.115	0.553	0.046	0.058
FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	0.001	0.653	0.999	0.999
fbp3; fructose-1,6-bisphosphatase III [EC:3.1.3.11]	1.115	0.553	0.046	0.058
fctD; glutamate formiminotransferase [EC:2.1.2.5]	1.355	0.641	0.036	0.058
feoA; ferrous iron transport protein A	0.551	0.679	0.419	0.451
feoB; ferrous iron transport protein B	0.551	0.679	0.419	0.451
fhaB; filamentous hemagglutinin	1.343	0.625	0.033	0.058
fhs; formate–tetrahydrofolate ligase [EC:6.3.4.3]	1.115	0.553	0.046	0.058
fixA, etfB; electron transfer flavoprotein beta subunit	1.134	0.578	0.051	0.064
fixB, etfA; electron transfer flavoprotein alpha subunit	1.134	0.578	0.051	0.064
fixC; electron transfer flavoprotein-quinone oxidoreductase [EC:1.5.5.-]	1.359	0.653	0.039	0.058
fldA, nifF, isiB; flavodoxin I	1.115	0.553	0.046	0.058
FLOT; flotillin	1.219	0.577	0.036	0.058
fnr; CRP/FNR family transcriptional regulator, anaerobic regulatory protein	1.115	0.553	0.046	0.058
folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]	1.115	0.553	0.046	0.058
folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]	1.115	0.553	0.046	0.058
folP; dihydropteroate synthase [EC:2.5.1.15]	1.115	0.553	0.046	0.058
frdA; fumarate reductase flavoprotein subunit [EC:1.3.5.4]	1.289	0.586	0.029	0.058
frr, MRRF, RRF; ribosome recycling factor	1.115	0.553	0.046	0.058
fruK; 1-phosphofructokinase [EC:2.7.1.56]	1.115	0.553	0.046	0.058
fruR2, fruR; DeoR family transcriptional regulator, fructose operon transcriptional repressor	1.115	0.553	0.046	0.058
FTR, FTH1, efeU; high-affinity iron transporter	1.352	0.629	0.033	0.058
ftsA; cell division protein FtsA	1.115	0.553	0.046	0.058
ftsH, hflB; cell division protease FtsH [EC:3.4.24.-]	1.115	0.553	0.046	0.058
ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]	1.115	0.553	0.046	0.058
ftsQ; cell division protein FtsQ	1.115	0.553	0.046	0.058
ftsW, spoVE; cell division protein FtsW	1.115	0.553	0.046	0.058
ftsX; cell division transport system permease protein	1.115	0.553	0.046	0.058
ftsY; fused signal recognition particle receptor	1.115	0.553	0.046	0.058
ftsZ; cell division protein FtsZ	1.115	0.553	0.046	0.058
fucA; L-fuculose-phosphate aldolase [EC:4.1.2.17]	1.155	0.607	0.059	0.072
fucO; lactaldehyde reductase [EC:1.1.1.77]	1.322	0.616	0.034	0.058
fur, zur, furB; Fur family transcriptional regulator, ferric uptake regulator	1.115	0.553	0.046	0.058
fusA, GFM, EFG; elongation factor G	1.115	0.553	0.046	0.058
fwdE, fmdE; formylmethanofuran dehydrogenase subunit E [EC:1.2.7.12]	1.359	0.653	0.039	0.058
galE, GALE; UDP-glucose 4-epimerase [EC:5.1.3.2]	1.113	0.561	0.049	0.062
galK; galactokinase [EC:2.7.1.6]	1.115	0.553	0.046	0.058
galM, GALM; aldose 1-epimerase [EC:5.1.3.3]	1.115	0.553	0.046	0.058
galT, GALT; UDPglucose–hexose-1-phosphate uridylyltransferase [EC:2.7.7.12]	1.115	0.553	0.046	0.058
GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]	1.115	0.553	0.046	0.058
gatA, QRSL1; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]	1.115	0.553	0.046	0.058
gatB, PET112; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]	1.115	0.553	0.046	0.058
gatC, GATC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]	1.115	0.553	0.046	0.058
GBE1, glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]	1.115	0.553	0.046	0.058
gcdA; glutaconyl-CoA decarboxylase [EC:4.1.1.70]	1.115	0.553	0.046	0.058
GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16]	1.115	0.553	0.046	0.058
gcpE, ispG; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3]	1.115	0.553	0.046	0.058
gctA; glutaconate CoA-transferase, subunit A [EC:2.8.3.12]	1.115	0.553	0.046	0.058
gctB; glutaconate CoA-transferase, subunit B [EC:2.8.3.12]	1.115	0.553	0.046	0.058
gfrE; glucoselysine-6-phosphate deglycase	1.359	0.653	0.039	0.058
gfrF; fructoselysine-6-phosphate deglycase	1.359	0.653	0.039	0.058
GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]	1.115	0.553	0.046	0.058
ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]	1.359	0.653	0.039	0.058
gidA, mnmG, MTO1; tRNA uridine 5-carboxymethylaminomethyl modification enzyme	1.115	0.553	0.046	0.058
gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]	1.115	0.553	0.046	0.058
glcD; glycolate oxidase [EC:1.1.3.15]	1.359	0.653	0.039	0.058
glgA; starch synthase [EC:2.4.1.21]	1.115	0.553	0.046	0.058
glgC; glucose-1-phosphate adenylyltransferase [EC:2.7.7.27]	1.115	0.553	0.046	0.058
glgX; glycogen debranching enzyme [EC:3.2.1.196]	1.115	0.553	0.046	0.058
glk; glucokinase [EC:2.7.1.2]	1.078	0.528	0.043	0.058
glmE, mutE, mamB; methylaspartate mutase epsilon subunit [EC:5.4.99.1]	1.289	0.586	0.029	0.058
glmM; phosphoglucosamine mutase [EC:5.4.2.10]	1.115	0.553	0.046	0.058
glmS, GFPT; glucosamine—fructose-6-phosphate aminotransferase (isomerizing) [EC:2.6.1.16]	1.115	0.553	0.046	0.058
glmS, mutS, mamA; methylaspartate mutase sigma subunit [EC:5.4.99.1]	1.115	0.553	0.046	0.058
glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]	1.115	0.553	0.046	0.058
glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	0.087	0.625	0.890	0.893
glnG, ntrC; two-component system, NtrC family, nitrogen regulation response regulator GlnG	1.115	0.553	0.046	0.058
GLO1, gloA; lactoylglutathione lyase [EC:4.4.1.5]	1.223	0.582	0.037	0.058
gloB, HAGH; hydroxyacylglutathione hydrolase [EC:3.1.2.6]	1.115	0.553	0.046	0.058
glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]	1.115	0.553	0.046	0.058
GLPF; glycerol uptake facilitator protein	1.115	0.553	0.046	0.058
glpK, GK; glycerol kinase [EC:2.7.1.30]	1.115	0.553	0.046	0.058
glpP; glycerol uptake operon antiterminator	1.115	0.553	0.046	0.058
glpX; fructose-1,6-bisphosphatase II [EC:3.1.3.11]	1.115	0.553	0.046	0.058
glsA, GLS; glutaminase [EC:3.5.1.2]	1.115	0.553	0.046	0.058
gltD; glutamate synthase (NADPH/NADH) small chain [EC:1.4.1.13 1.4.1.14]	-0.298	0.779	0.702	0.720
gltS; glutamate:Na+ symporter, ESS family	1.066	0.545	0.052	0.065
glvA; maltose-6’-phosphate glucosidase [EC:3.2.1.122]	0.551	0.679	0.419	0.451
glxK, garK; glycerate 2-kinase [EC:2.7.1.165]	-0.298	0.779	0.702	0.720
glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1]	-0.298	0.779	0.702	0.720
glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]	1.115	0.553	0.046	0.058
glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]	1.115	0.553	0.046	0.058
gmhA, lpcA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]	1.115	0.553	0.046	0.058
gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83]	-0.298	0.779	0.702	0.720
gmhD, rfaD; ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]	1.115	0.553	0.046	0.058
GPI, pgi; glucose-6-phosphate isomerase [EC:5.3.1.9]	1.115	0.553	0.046	0.058
gpmB; probable phosphoglycerate mutase [EC:5.4.2.12]	1.115	0.553	0.046	0.058
gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	-0.298	0.779	0.702	0.720
gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]	1.115	0.553	0.046	0.058
gpx; glutathione peroxidase [EC:1.11.1.9]	1.115	0.553	0.046	0.058
groEL, HSPD1; chaperonin GroEL	1.115	0.553	0.046	0.058
groES, HSPE1; chaperonin GroES	1.115	0.553	0.046	0.058
GRPE; molecular chaperone GrpE	1.115	0.553	0.046	0.058
gspD; general secretion pathway protein D	1.115	0.553	0.046	0.058
gspE; general secretion pathway protein E	1.158	0.588	0.051	0.063
gspF; general secretion pathway protein F	1.289	0.586	0.029	0.058
gspG; general secretion pathway protein G	1.115	0.553	0.046	0.058
guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	1.115	0.553	0.046	0.058
gudB, rocG; glutamate dehydrogenase [EC:1.4.1.2]	1.115	0.553	0.046	0.058
gyrA; DNA gyrase subunit A [EC:5.99.1.3]	1.115	0.553	0.046	0.058
gyrB; DNA gyrase subunit B [EC:5.99.1.3]	1.115	0.553	0.046	0.058
HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21]	1.115	0.553	0.046	0.058
hcp; hydroxylamine reductase [EC:1.7.99.1]	1.115	0.553	0.046	0.058
hdrA2; heterodisulfide reductase subunit A2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]	0.551	0.679	0.419	0.451
hdrB2; heterodisulfide reductase subunit B2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]	0.551	0.679	0.419	0.451
hdrC2; heterodisulfide reductase subunit C2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]	0.551	0.679	0.419	0.451
hemA; glutamyl-tRNA reductase [EC:1.2.1.70]	1.115	0.553	0.046	0.058
hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	1.115	0.553	0.046	0.058
hemC, HMBS; hydroxymethylbilane synthase [EC:2.5.1.61]	1.115	0.553	0.046	0.058
hemK, prmC, HEMK; release factor glutamine methyltransferase [EC:2.1.1.297]	1.115	0.553	0.046	0.058
hemL; glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8]	1.115	0.553	0.046	0.058
hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	1.053	0.541	0.053	0.066
hepST; heptaprenyl diphosphate synthase [EC:2.5.1.30]	1.223	0.591	0.040	0.058
hflX; GTPase	1.115	0.553	0.046	0.058
higB-1; toxin HigB-1	1.352	0.629	0.033	0.058
HINT1, hinT, hit; histidine triad (HIT) family protein	1.115	0.553	0.046	0.058
hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1]	1.359	0.653	0.039	0.058
hipO; hippurate hydrolase [EC:3.5.1.32]	0.551	0.679	0.419	0.451
hlpA, ompH; outer membrane protein	1.115	0.553	0.046	0.058
hlyIII; hemolysin III	1.115	0.553	0.046	0.058
hndA; NADP-reducing hydrogenase subunit HndA [EC:1.12.1.3]	0.551	0.679	0.419	0.451
hndC; NADP-reducing hydrogenase subunit HndC [EC:1.12.1.3]	0.551	0.679	0.419	0.451
hndD; NADP-reducing hydrogenase subunit HndD [EC:1.12.1.3]	0.551	0.679	0.419	0.451
holA; DNA polymerase III subunit delta [EC:2.7.7.7]	1.115	0.553	0.046	0.058
holB; DNA polymerase III subunit delta’ [EC:2.7.7.7]	1.115	0.553	0.046	0.058
hppA; K(+)-stimulated pyrophosphate-energized sodium pump [EC:3.6.1.1]	1.115	0.553	0.046	0.058
hprA; glycerate dehydrogenase [EC:1.1.1.29]	1.289	0.586	0.029	0.058
hprK, ptsK; HPr kinase/phosphorylase [EC:2.7.11.- 2.7.4.-]	1.115	0.553	0.046	0.058
hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]	1.115	0.553	0.046	0.058
hrcA; heat-inducible transcriptional repressor	1.115	0.553	0.046	0.058
hsdM; type I restriction enzyme M protein [EC:2.1.1.72]	1.119	0.539	0.040	0.058
hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]	1.223	0.582	0.037	0.058
hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]	1.223	0.574	0.035	0.058
hslO; molecular chaperone Hsp33	1.115	0.553	0.046	0.058
hslU; ATP-dependent HslUV protease ATP-binding subunit HslU	0.551	0.679	0.419	0.451
hslV, clpQ; ATP-dependent HslUV protease, peptidase subunit HslV [EC:3.4.25.2]	0.551	0.679	0.419	0.451
HSP90A, htpG; molecular chaperone HtpG	1.115	0.553	0.046	0.058
htpX; heat shock protein HtpX [EC:3.4.24.-]	1.115	0.553	0.046	0.058
hupB; DNA-binding protein HU-beta	0.945	0.526	0.074	0.090
hutG; formiminoglutamase [EC:3.5.3.8]	1.115	0.553	0.046	0.058
hutH, HAL; histidine ammonia-lyase [EC:4.3.1.3]	1.223	0.591	0.040	0.058
hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7]	1.223	0.591	0.040	0.058
hutU, UROC1; urocanate hydratase [EC:4.2.1.49]	1.223	0.591	0.040	0.058
IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5]	1.115	0.553	0.046	0.058
IDH3; isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]	1.359	0.653	0.039	0.058
idnO; gluconate 5-dehydrogenase [EC:1.1.1.69]	1.359	0.653	0.039	0.058
ilvC; ketol-acid reductoisomerase [EC:1.1.1.86]	0.802	0.500	0.111	0.131
ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	0.802	0.500	0.111	0.131
IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205]	1.115	0.553	0.046	0.058
infA; translation initiation factor IF-1	1.115	0.553	0.046	0.058
infB, MTIF2; translation initiation factor IF-2	1.115	0.553	0.046	0.058
infC, MTIF3; translation initiation factor IF-3	1.115	0.553	0.046	0.058
INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	0.551	0.679	0.419	0.451
iscS, NFS1; cysteine desulfurase [EC:2.8.1.7]	1.119	0.539	0.040	0.058
iscU, nifU; nitrogen fixation protein NifU and related proteins	1.115	0.553	0.046	0.058
ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60]	1.115	0.553	0.046	0.058
ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148]	1.115	0.553	0.046	0.058
ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12]	1.115	0.553	0.046	0.058
ispH, lytB; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4]	1.115	0.553	0.046	0.058
jag; spoIIIJ-associated protein	1.115	0.553	0.046	0.058
K00243; uncharacterized protein	1.115	0.553	0.046	0.058
K00375; GntR family transcriptional regulator / MocR family aminotransferase	1.352	0.629	0.033	0.058
K01138; uncharacterized sulfatase [EC:3.1.6.-]	0.551	0.679	0.419	0.451
K01163; uncharacterized protein	1.115	0.553	0.046	0.058
K01436; amidohydrolase [EC:3.5.1.-]	1.060	0.557	0.059	0.072
K02477; two-component system, LytTR family, response regulator	1.115	0.553	0.046	0.058
K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]	1.115	0.553	0.046	0.058
K02481; two-component system, NtrC family, response regulator	1.289	0.586	0.029	0.058
K03653; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]	1.115	0.553	0.046	0.058
K03710; GntR family transcriptional regulator	0.551	0.679	0.419	0.451
K06867; uncharacterized protein	1.359	0.653	0.039	0.058
K06871; uncharacterized protein	-0.298	0.779	0.702	0.720
K06885; uncharacterized protein	1.158	0.588	0.051	0.063
K06889; uncharacterized protein	1.158	0.588	0.051	0.063
K06890; uncharacterized protein	1.115	0.553	0.046	0.058
K06894; uncharacterized protein	1.115	0.553	0.046	0.058
K06905; uncharacterized protein	1.219	0.577	0.036	0.058
K06906; uncharacterized protein	1.219	0.577	0.036	0.058
K06907; uncharacterized protein	1.219	0.577	0.036	0.058
K06908; uncharacterized protein	1.219	0.577	0.036	0.058
K06915; uncharacterized protein	1.359	0.653	0.039	0.058
K06921; uncharacterized protein	1.352	0.629	0.033	0.058
K06926; uncharacterized protein	1.359	0.653	0.039	0.058
K06960; uncharacterized protein	1.115	0.553	0.046	0.058
K06975; uncharacterized protein	1.115	0.553	0.046	0.058
K07001; NTE family protein	1.078	0.528	0.043	0.058
K07005; uncharacterized protein	1.352	0.629	0.033	0.058
K07006; uncharacterized protein	1.158	0.588	0.051	0.063
K07010; putative glutamine amidotransferase	1.115	0.553	0.046	0.058
K07019; uncharacterized protein	-0.298	0.779	0.702	0.720
K07025; putative hydrolase of the HAD superfamily	0.551	0.679	0.419	0.451
K07030; uncharacterized protein	1.115	0.553	0.046	0.058
K07032; uncharacterized protein	1.359	0.653	0.039	0.058
K07035; uncharacterized protein	1.115	0.553	0.046	0.058
K07037; uncharacterized protein	1.115	0.553	0.046	0.058
K07040; uncharacterized protein	0.551	0.679	0.419	0.451
K07043; uncharacterized protein	1.115	0.553	0.046	0.058
K07052; uncharacterized protein	1.250	0.613	0.043	0.058
K07058; membrane protein	1.115	0.553	0.046	0.058
K07069; uncharacterized protein	1.115	0.553	0.046	0.058
K07082; UPF0755 protein	1.115	0.553	0.046	0.058
K07085; putative transport protein	1.289	0.586	0.029	0.058
K07088; uncharacterized protein	0.970	0.550	0.080	0.096
K07089; uncharacterized protein	0.802	0.500	0.111	0.131
K07090; uncharacterized protein	1.046	0.509	0.042	0.058
K07095; uncharacterized protein	1.078	0.528	0.043	0.058
K07097; uncharacterized protein	1.352	0.629	0.033	0.058
K07098; uncharacterized protein	0.551	0.679	0.419	0.451
K07105; uncharacterized protein	1.115	0.553	0.046	0.058
K07120; uncharacterized protein	1.115	0.553	0.046	0.058
K07124; uncharacterized protein	1.115	0.553	0.046	0.058
K07126; uncharacterized protein	1.219	0.577	0.036	0.058
K07133; uncharacterized protein	1.190	0.584	0.043	0.058
K07137; uncharacterized protein	0.945	0.526	0.074	0.090
K07139; uncharacterized protein	1.115	0.553	0.046	0.058
K07150; uncharacterized protein	1.111	0.570	0.053	0.065
K07160; UPF0271 protein	1.158	0.588	0.051	0.063
K07166; ACT domain-containing protein	-0.298	0.779	0.702	0.720
K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	-0.298	0.779	0.702	0.720
K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	1.359	0.653	0.039	0.058
K07461; putative endonuclease	1.115	0.553	0.046	0.058
K07483; transposase	1.319	0.606	0.031	0.058
K07485; transposase	1.342	0.597	0.026	0.058
K07486; transposase	1.359	0.653	0.039	0.058
K07487; transposase	1.359	0.653	0.039	0.058
K07491; putative transposase	0.087	0.625	0.890	0.893
K07496; putative transposase	0.980	0.465	0.036	0.058
K07497; putative transposase	1.340	0.592	0.025	0.058
K07727; putative transcriptional regulator	0.087	0.625	0.890	0.893
K08303; putative protease [EC:3.4.-.-]	1.115	0.553	0.046	0.058
K08884; serine/threonine protein kinase, bacterial [EC:2.7.11.1]	1.115	0.553	0.046	0.058
K08974; putative membrane protein	1.115	0.553	0.046	0.058
K08998; uncharacterized protein	1.115	0.553	0.046	0.058
K09125; uncharacterized protein	1.115	0.553	0.046	0.058
K09155; uncharacterized protein	1.352	0.629	0.033	0.058
K09157; uncharacterized protein	-0.298	0.779	0.702	0.720
K09729; uncharacterized protein	1.115	0.553	0.046	0.058
K09747; uncharacterized protein	1.115	0.553	0.046	0.058
K09762; uncharacterized protein	1.115	0.553	0.046	0.058
K09769; uncharacterized protein	1.115	0.553	0.046	0.058
K09775; uncharacterized protein	-0.298	0.779	0.702	0.720
K09778; uncharacterized protein	1.115	0.553	0.046	0.058
K09780; uncharacterized protein	1.359	0.653	0.039	0.058
K09787; uncharacterized protein	1.115	0.553	0.046	0.058
K09790; uncharacterized protein	1.115	0.553	0.046	0.058
K09802; uncharacterized protein	1.115	0.553	0.046	0.058
K09858; SEC-C motif domain protein	0.551	0.679	0.419	0.451
K09861; uncharacterized protein	1.115	0.553	0.046	0.058
K09935; uncharacterized protein	1.219	0.577	0.036	0.058
K09949; uncharacterized protein	1.115	0.553	0.046	0.058
K11145; ribonuclease III family protein [EC:3.1.26.-]	1.115	0.553	0.046	0.058
K13653; AraC family transcriptional regulator	1.359	0.653	0.039	0.058
K15024; putative phosphotransacetylase [EC:2.3.1.8]	1.219	0.577	0.036	0.058
KAE1, tsaD, QRI7; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]	1.115	0.553	0.046	0.058
kal; 3-aminobutyryl-CoA ammonia-lyase [EC:4.3.1.14]	1.115	0.553	0.046	0.058
kamA; lysine 2,3-aminomutase [EC:5.4.3.2]	1.115	0.553	0.046	0.058
kamD; beta-lysine 5,6-aminomutase alpha subunit [EC:5.4.3.3]	1.115	0.553	0.046	0.058
kamE; beta-lysine 5,6-aminomutase beta subunit [EC:5.4.3.3]	1.115	0.553	0.046	0.058
KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]	1.115	0.553	0.046	0.058
kce; 3-keto-5-aminohexanoate cleavage enzyme [EC:2.3.1.247]	1.115	0.553	0.046	0.058
kdd; L-erythro-3,5-diaminohexanoate dehydrogenase [EC:1.4.1.11]	1.115	0.553	0.046	0.058
kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45]	-0.298	0.779	0.702	0.720
kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55]	1.115	0.553	0.046	0.058
kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38]	1.115	0.553	0.046	0.058
kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45]	1.115	0.553	0.046	0.058
kdsD, kpsF; arabinose-5-phosphate isomerase [EC:5.3.1.13]	1.115	0.553	0.046	0.058
kduD; 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase [EC:1.1.1.127]	0.551	0.679	0.419	0.451
kduI; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase [EC:5.3.1.17]	0.551	0.679	0.419	0.451
kptA; putative RNA 2’-phosphotransferase [EC:2.7.1.-]	1.352	0.629	0.033	0.058
ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]	1.115	0.553	0.046	0.058
lacI, galR; LacI family transcriptional regulator	0.001	0.653	0.999	0.999
LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4]	1.115	0.553	0.046	0.058
ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]	0.551	0.679	0.419	0.451
LDH, ldh; L-lactate dehydrogenase [EC:1.1.1.27]	1.115	0.553	0.046	0.058
ldhA; D-lactate dehydrogenase [EC:1.1.1.28]	1.115	0.553	0.046	0.058
lemA; LemA protein	1.115	0.553	0.046	0.058
lepA; GTP-binding protein LepA	1.115	0.553	0.046	0.058
lepB; signal peptidase I [EC:3.4.21.89]	1.115	0.553	0.046	0.058
leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	1.219	0.577	0.036	0.058
leuB, IMDH; 3-isopropylmalate dehydrogenase [EC:1.1.1.85]	1.219	0.577	0.036	0.058
leuC, IPMI-L; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]	0.802	0.500	0.111	0.131
leuD, IPMI-S; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]	0.802	0.500	0.111	0.131
lexA; repressor LexA [EC:3.4.21.88]	1.286	0.569	0.025	0.058
lgt, umpA; phosphatidylglycerol:prolipoprotein diacylglycerol transferase [EC:2.-.-.-]	1.115	0.553	0.046	0.058
licD; lipopolysaccharide cholinephosphotransferase [EC:2.7.8.-]	1.352	0.629	0.033	0.058
lip, TGL2; triacylglycerol lipase [EC:3.1.1.3]	1.352	0.629	0.033	0.058
livF; branched-chain amino acid transport system ATP-binding protein	1.115	0.553	0.046	0.058
livG; branched-chain amino acid transport system ATP-binding protein	1.115	0.553	0.046	0.058
livH; branched-chain amino acid transport system permease protein	1.115	0.553	0.046	0.058
livK; branched-chain amino acid transport system substrate-binding protein	1.115	0.553	0.046	0.058
livM; branched-chain amino acid transport system permease protein	1.115	0.553	0.046	0.058
lldG; L-lactate dehydrogenase complex protein LldG	1.359	0.653	0.039	0.058
lolC_E; lipoprotein-releasing system permease protein	1.115	0.553	0.046	0.058
lolD; lipoprotein-releasing system ATP-binding protein [EC:3.6.3.-]	1.115	0.553	0.046	0.058
lon; ATP-dependent Lon protease [EC:3.4.21.53]	1.223	0.591	0.040	0.058
lptB; lipopolysaccharide export system ATP-binding protein [EC:3.6.3.-]	1.115	0.553	0.046	0.058
lptF; lipopolysaccharide export system permease protein	1.115	0.553	0.046	0.058
lptG; lipopolysaccharide export system permease protein	1.115	0.553	0.046	0.058
lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]	1.115	0.553	0.046	0.058
lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]	1.115	0.553	0.046	0.058
lpxC; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [EC:3.5.1.108]	1.115	0.553	0.046	0.058
lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191]	1.223	0.591	0.040	0.058
lpxK; tetraacyldisaccharide 4’-kinase [EC:2.7.1.130]	1.115	0.553	0.046	0.058
lpxL, htrB; Kdo2-lipid IVA lauroyltransferase [EC:2.3.1.241]	1.119	0.539	0.040	0.058
LRA3, yfaW; L-rhamnonate dehydratase [EC:4.2.1.90]	1.359	0.653	0.039	0.058
lspA; signal peptidase II [EC:3.4.23.36]	1.115	0.553	0.046	0.058
ltaE; threonine aldolase [EC:4.1.2.48]	1.115	0.553	0.046	0.058
luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21]	1.219	0.577	0.036	0.058
lysA; diaminopimelate decarboxylase [EC:4.1.1.20]	0.551	0.679	0.419	0.451
lysC; aspartate kinase [EC:2.7.2.4]	0.087	0.625	0.890	0.893
lysE, argO; L-lysine exporter family protein LysE/ArgO	1.115	0.553	0.046	0.058
maf; septum formation protein	1.115	0.553	0.046	0.058
mal; methylaspartate ammonia-lyase [EC:4.3.1.2]	0.551	0.679	0.419	0.451
malQ; 4-alpha-glucanotransferase [EC:2.4.1.25]	1.115	0.553	0.046	0.058
manA, MPI; mannose-6-phosphate isomerase [EC:5.3.1.8]	-0.298	0.779	0.702	0.720
map; methionyl aminopeptidase [EC:3.4.11.18]	1.115	0.553	0.046	0.058
MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]	1.115	0.553	0.046	0.058
mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-]	1.219	0.577	0.036	0.058
mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC	1.219	0.577	0.036	0.058
ME2, sfcA, maeA; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]	-0.298	0.779	0.702	0.720
menA; 1,4-dihydroxy-2-naphthoate octaprenyltransferase [EC:2.5.1.74 2.5.1.-]	1.359	0.653	0.039	0.058
MET8; precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:1.3.1.76 4.99.1.4]	1.115	0.553	0.046	0.058
metA; homoserine O-succinyltransferase/O-acetyltransferase [EC:2.3.1.46 2.3.1.31]	1.219	0.577	0.036	0.058
metB; cystathionine gamma-synthase [EC:2.5.1.48]	1.355	0.641	0.036	0.058
metC; cystathionine beta-lyase [EC:4.4.1.8]	1.359	0.653	0.039	0.058
metF, MTHFR; methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]	0.087	0.625	0.890	0.893
metH, MTR; 5-methyltetrahydrofolate–homocysteine methyltransferase [EC:2.1.1.13]	1.115	0.553	0.046	0.058
metI; D-methionine transport system permease protein	1.115	0.553	0.046	0.058
metK; S-adenosylmethionine synthetase [EC:2.5.1.6]	1.115	0.553	0.046	0.058
metN; D-methionine transport system ATP-binding protein	1.115	0.553	0.046	0.058
metQ; D-methionine transport system substrate-binding protein	0.954	0.514	0.065	0.080
metY; O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49]	0.802	0.500	0.111	0.131
mfd; transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-]	1.115	0.553	0.046	0.058
mglA; methyl-galactoside transport system ATP-binding protein [EC:3.6.3.17]	1.115	0.553	0.046	0.058
mglB; methyl-galactoside transport system substrate-binding protein	1.115	0.553	0.046	0.058
mglC; methyl-galactoside transport system permease protein	1.115	0.553	0.046	0.058
mgsA; methylglyoxal synthase [EC:4.2.3.3]	0.551	0.679	0.419	0.451
mgtA, mgtB; Mg2+-importing ATPase [EC:3.6.3.2]	-1.604	1.840	0.385	0.450
mgtC; putative Mg2+ transporter-C (MgtC) family protein	1.115	0.553	0.046	0.058
mgtE; magnesium transporter	1.115	0.553	0.046	0.058
miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	1.115	0.553	0.046	0.058
miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]	1.115	0.553	0.046	0.058
minC; septum site-determining protein MinC	1.115	0.553	0.046	0.058
minD; septum site-determining protein MinD	1.115	0.553	0.046	0.058
minE; cell division topological specificity factor	1.115	0.553	0.046	0.058
mipA, ompV; MipA family protein	1.115	0.553	0.046	0.058
mlaA, vacJ; phospholipid-binding lipoprotein MlaA	1.115	0.553	0.046	0.058
MMAB, pduO; cob(I)alamin adenosyltransferase [EC:2.5.1.17]	1.346	0.609	0.029	0.058
mnmA, trmU; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]	1.115	0.553	0.046	0.058
mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-]	1.115	0.553	0.046	0.058
moaA, CNX2; GTP 3’,8-cyclase [EC:4.1.99.22]	0.551	0.679	0.419	0.451
moaC, CNX3; cyclic pyranopterin monophosphate synthase [EC:4.6.1.17]	0.551	0.679	0.419	0.451
mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	0.915	0.466	0.051	0.064
modA; molybdate transport system substrate-binding protein	0.551	0.679	0.419	0.451
modB; molybdate transport system permease protein	0.551	0.679	0.419	0.451
motB; chemotaxis protein MotB	1.289	0.586	0.029	0.058
moxR; MoxR-like ATPase [EC:3.6.3.-]	0.551	0.679	0.419	0.451
mraW, rsmH; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]	1.115	0.553	0.046	0.058
mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]	1.115	0.553	0.046	0.058
mrcA; penicillin-binding protein 1A [EC:2.4.1.129 3.4.16.4]	1.115	0.553	0.046	0.058
mrdA; penicillin-binding protein 2 [EC:3.4.16.4]	1.115	0.553	0.046	0.058
mreB; rod shape-determining protein MreB and related proteins	1.115	0.553	0.046	0.058
mreC; rod shape-determining protein MreC	1.115	0.553	0.046	0.058
msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:3.6.3.-]	1.115	0.553	0.046	0.058
mscL; large conductance mechanosensitive channel	1.115	0.553	0.046	0.058
mscS; small conductance mechanosensitive channel	1.078	0.528	0.043	0.058
msmX, msmK, malK, sugC, ggtA, msiK; multiple sugar transport system ATP-binding protein	-0.298	0.779	0.702	0.720
msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12]	1.223	0.582	0.037	0.058
mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5]	1.115	0.553	0.046	0.058
MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9]	1.115	0.553	0.046	0.058
MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]	1.115	0.553	0.046	0.058
mtnA; methylthioribose-1-phosphate isomerase [EC:5.3.1.23]	1.359	0.653	0.039	0.058
mtnK; 5-methylthioribose kinase [EC:2.7.1.100]	1.359	0.653	0.039	0.058
mtnN, mtn, pfs; adenosylhomocysteine nucleosidase [EC:3.2.2.9]	1.115	0.553	0.046	0.058
murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	1.115	0.553	0.046	0.058
murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	1.115	0.553	0.046	0.058
murC; UDP-N-acetylmuramate–alanine ligase [EC:6.3.2.8]	1.115	0.553	0.046	0.058
murD; UDP-N-acetylmuramoylalanine–D-glutamate ligase [EC:6.3.2.9]	1.115	0.553	0.046	0.058
murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase [EC:6.3.2.13]	1.115	0.553	0.046	0.058
murF; UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase [EC:6.3.2.10]	1.078	0.528	0.043	0.058
murG; UDP-N-acetylglucosamine–N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]	1.115	0.553	0.046	0.058
murI; glutamate racemase [EC:5.1.1.3]	1.083	0.516	0.037	0.058
murJ, mviN; putative peptidoglycan lipid II flippase	1.223	0.582	0.037	0.058
murR; RpiR family transcriptional regulator, murPQ operon repressor	-1.604	1.840	0.385	0.450
mutL; DNA mismatch repair protein MutL	1.115	0.553	0.046	0.058
mutS; DNA mismatch repair protein MutS	1.115	0.553	0.046	0.058
mutS2; DNA mismatch repair protein MutS2	1.115	0.553	0.046	0.058
mutT, NUDT15, MTH2; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]	1.223	0.582	0.037	0.058
nadA; quinolinate synthase [EC:2.5.1.72]	1.115	0.553	0.046	0.058
nadB; L-aspartate oxidase [EC:1.4.3.16]	1.115	0.553	0.046	0.058
nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]	1.115	0.553	0.046	0.058
nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]	1.115	0.553	0.046	0.058
nadE; NAD+ synthase [EC:6.3.1.5]	1.115	0.553	0.046	0.058
nagA, AMDHD2; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25]	1.115	0.553	0.046	0.058
nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6]	1.115	0.553	0.046	0.058
nagC; N-acetylglucosamine repressor	-0.298	0.779	0.702	0.720
nagD; NagD protein	1.158	0.588	0.051	0.063
nanE; N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9]	1.115	0.553	0.046	0.058
NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22]	1.115	0.553	0.046	0.058
nasT; two-component system, response regulator / RNA-binding antiterminator	1.352	0.629	0.033	0.058
ncd2, npd; nitronate monooxygenase [EC:1.13.12.16]	1.352	0.629	0.033	0.058
nfdA; N-substituted formamide deformylase [EC:3.5.1.91]	1.155	0.607	0.059	0.072
nfo; deoxyribonuclease IV [EC:3.1.21.2]	0.551	0.679	0.419	0.451
nhaC; Na+:H+ antiporter, NhaC family	1.199	0.586	0.042	0.058
nifH; nitrogenase iron protein NifH [EC:1.18.6.1]	1.352	0.629	0.033	0.058
nikA; nickel transport system substrate-binding protein	1.352	0.629	0.033	0.058
nikB; nickel transport system permease protein	1.352	0.629	0.033	0.058
nikC; nickel transport system permease protein	1.352	0.629	0.033	0.058
nikD; nickel transport system ATP-binding protein [EC:3.6.3.24]	1.352	0.629	0.033	0.058
nikE; nickel transport system ATP-binding protein [EC:3.6.3.24]	1.352	0.629	0.033	0.058
nirA; ferredoxin-nitrite reductase [EC:1.7.7.1]	0.551	0.679	0.419	0.451
npdA; NAD-dependent deacetylase [EC:3.5.1.-]	1.123	0.527	0.035	0.058
NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]	1.219	0.577	0.036	0.058
nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4]	1.115	0.553	0.046	0.058
nrdR; transcriptional repressor NrdR	1.115	0.553	0.046	0.058
nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]	1.115	0.553	0.046	0.058
NTH; endonuclease III [EC:4.2.99.18]	1.123	0.527	0.035	0.058
nudF; ADP-ribose pyrophosphatase [EC:3.6.1.13]	1.115	0.553	0.046	0.058
nuoE; NADH-quinone oxidoreductase subunit E [EC:1.6.5.3]	-0.298	0.779	0.702	0.720
nuoF; NADH-quinone oxidoreductase subunit F [EC:1.6.5.3]	0.551	0.679	0.419	0.451
nuoG; NADH-quinone oxidoreductase subunit G [EC:1.6.5.3]	-0.298	0.779	0.702	0.720
nusA; N utilization substance protein A	1.115	0.553	0.046	0.058
nusB; N utilization substance protein B	1.115	0.553	0.046	0.058
nusG; transcriptional antiterminator NusG	1.115	0.553	0.046	0.058
oadA; oxaloacetate decarboxylase, alpha subunit [EC:4.1.1.3]	1.115	0.553	0.046	0.058
oadB; oxaloacetate decarboxylase, beta subunit [EC:4.1.1.3]	1.115	0.553	0.046	0.058
obgE, cgtA; GTPase [EC:3.6.5.-]	1.115	0.553	0.046	0.058
ogt, MGMT; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]	1.115	0.553	0.046	0.058
oppD; oligopeptide transport system ATP-binding protein	1.115	0.553	0.046	0.058
oppF; oligopeptide transport system ATP-binding protein	1.250	0.613	0.043	0.058
opuA; osmoprotectant transport system ATP-binding protein	1.115	0.553	0.046	0.058
opuBD; osmoprotectant transport system permease protein	1.115	0.553	0.046	0.058
oraE; D-ornithine 4,5-aminomutase subunit beta [EC:5.4.3.5]	1.219	0.577	0.036	0.058
oraS; D-ornithine 4,5-aminomutase subunit alpha [EC:5.4.3.5]	1.219	0.577	0.036	0.058
p19, ftrA; periplasmic iron binding protein	1.352	0.629	0.033	0.058
paaH, hbd, fadB, mmgB; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]	1.115	0.553	0.046	0.058
pabA; para-aminobenzoate synthetase component II [EC:2.6.1.85]	1.352	0.629	0.033	0.058
pabB; para-aminobenzoate synthetase component I [EC:2.6.1.85]	1.352	0.629	0.033	0.058
pabC; 4-amino-4-deoxychorismate lyase [EC:4.1.3.38]	1.289	0.586	0.029	0.058
panF; sodium/pantothenate symporter	1.115	0.553	0.046	0.058
parA, soj; chromosome partitioning protein	0.306	0.561	0.586	0.629
PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15]	1.115	0.553	0.046	0.058
patA; aminotransferase [EC:2.6.1.-]	-0.298	0.779	0.702	0.720
patB, malY; cystathione beta-lyase [EC:4.4.1.8]	1.043	0.542	0.056	0.069
pbpC; penicillin-binding protein 1C [EC:2.4.1.129]	1.115	0.553	0.046	0.058
pbuG; putative MFS transporter, AGZA family, xanthine/uracil permease	1.190	0.588	0.045	0.058
pcp; pyroglutamyl-peptidase [EC:3.4.19.3]	1.115	0.553	0.046	0.058
pct; propionate CoA-transferase [EC:2.8.3.1]	-0.298	0.779	0.702	0.720
PDF, def; peptide deformylase [EC:3.5.1.88]	1.115	0.553	0.046	0.058
pdhR; GntR family transcriptional regulator, transcriptional repressor for pyruvate dehydrogenase complex	0.551	0.679	0.419	0.451
pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3]	1.264	0.602	0.037	0.058
pduC; propanediol dehydratase large subunit [EC:4.2.1.28]	1.219	0.577	0.036	0.058
pduD; propanediol dehydratase medium subunit [EC:4.2.1.28]	1.219	0.577	0.036	0.058
pduE; propanediol dehydratase small subunit [EC:4.2.1.28]	1.219	0.577	0.036	0.058
pduP; propionaldehyde dehydrogenase [EC:1.2.1.87]	1.219	0.577	0.036	0.058
pdxA; 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262]	-0.215	0.897	0.811	0.827
pdxK, pdxY; pyridoxine kinase [EC:2.7.1.35]	-0.298	0.779	0.702	0.720
pdxS, pdx1; pyridoxal 5’-phosphate synthase pdxS subunit [EC:4.3.3.6]	1.115	0.553	0.046	0.058
pdxT, pdx2; 5’-phosphate synthase pdxT subunit [EC:4.3.3.6]	0.551	0.679	0.419	0.451
penP; beta-lactamase class A [EC:3.5.2.6]	1.289	0.586	0.029	0.058
pepD; dipeptidase D [EC:3.4.13.-]	1.264	0.602	0.037	0.058
pepE; dipeptidase E [EC:3.4.13.21]	1.352	0.629	0.033	0.058
pepF, pepB; oligoendopeptidase F [EC:3.4.24.-]	1.115	0.553	0.046	0.058
pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]	1.115	0.553	0.046	0.058
pepQ; Xaa-Pro dipeptidase [EC:3.4.13.9]	1.115	0.553	0.046	0.058
pepT; tripeptide aminopeptidase [EC:3.4.11.4]	1.115	0.553	0.046	0.058
perR; Fur family transcriptional regulator, peroxide stress response regulator	1.115	0.553	0.046	0.058
pezT; UDP-N-acetylglucosamine kinase [EC:2.7.1.176]	1.219	0.577	0.036	0.058
pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]	1.115	0.553	0.046	0.058
pflA, pflC, pflE; pyruvate formate lyase activating enzyme [EC:1.97.1.4]	1.115	0.553	0.046	0.058
PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]	1.250	0.613	0.043	0.058
PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3]	1.115	0.553	0.046	0.058
pgm; phosphoglucomutase [EC:5.4.2.2]	1.115	0.553	0.046	0.058
pgpA; phosphatidylglycerophosphatase A [EC:3.1.3.27]	1.115	0.553	0.046	0.058
pgsA, PGS1; CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	1.136	0.569	0.048	0.061
pheA; chorismate mutase / prephenate dehydratase [EC:5.4.99.5 4.2.1.51]	0.551	0.679	0.419	0.451
pheB; chorismate mutase [EC:5.4.99.5]	1.115	0.553	0.046	0.058
pheC; cyclohexadienyl dehydratase [EC:4.2.1.51 4.2.1.91]	-1.604	1.840	0.385	0.450
phnC; phosphonate transport system ATP-binding protein [EC:3.6.3.28]	1.352	0.629	0.033	0.058
phnD; phosphonate transport system substrate-binding protein	1.352	0.629	0.033	0.058
phnE; phosphonate transport system permease protein	1.352	0.629	0.033	0.058
phoB1, phoP; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP	-0.298	0.779	0.702	0.720
phoH2; PhoH-like ATPase	-0.298	0.779	0.702	0.720
phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]	-0.298	0.779	0.702	0.720
phoU; phosphate transport system protein	-0.298	0.779	0.702	0.720
pilB; type IV pilus assembly protein PilB	1.115	0.553	0.046	0.058
pilC; type IV pilus assembly protein PilC	1.115	0.553	0.046	0.058
pilD, pppA; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]	1.115	0.553	0.046	0.058
pilT; twitching motility protein PilT	1.115	0.553	0.046	0.058
pip; proline iminopeptidase [EC:3.4.11.5]	1.352	0.629	0.033	0.058
PK, pyk; pyruvate kinase [EC:2.7.1.40]	1.115	0.553	0.046	0.058
plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]	0.551	0.679	0.419	0.451
plsX; glycerol-3-phosphate acyltransferase PlsX [EC:2.3.1.15]	1.115	0.553	0.046	0.058
plsY; glycerol-3-phosphate acyltransferase PlsY [EC:2.3.1.15]	1.115	0.553	0.046	0.058
pncB, NAPRT1; nicotinate phosphoribosyltransferase [EC:6.3.4.21]	1.115	0.553	0.046	0.058
pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42]	1.115	0.553	0.046	0.058
pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]	1.115	0.553	0.046	0.058
polA; DNA polymerase I [EC:2.7.7.7]	1.115	0.553	0.046	0.058
polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]	1.115	0.553	0.046	0.058
por, nifJ; pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-]	1.309	0.625	0.038	0.058
porA; pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]	0.551	0.679	0.419	0.451
porG; pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]	0.551	0.679	0.419	0.451
potA; spermidine/putrescine transport system ATP-binding protein [EC:3.6.3.31]	1.115	0.553	0.046	0.058
potB; spermidine/putrescine transport system permease protein	1.115	0.553	0.046	0.058
potC; spermidine/putrescine transport system permease protein	1.115	0.553	0.046	0.058
potD; spermidine/putrescine transport system substrate-binding protein	1.115	0.553	0.046	0.058
ppa; inorganic pyrophosphatase [EC:3.6.1.1]	1.359	0.653	0.039	0.058
ppaC; manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1]	1.115	0.553	0.046	0.058
ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1]	1.115	0.553	0.046	0.058
pphA; serine/threonine protein phosphatase 1 [EC:3.1.3.16]	1.219	0.577	0.036	0.058
PPIB, ppiB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]	1.115	0.553	0.046	0.058
ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8]	1.115	0.553	0.046	0.058
ppnK, NADK; NAD+ kinase [EC:2.7.1.23]	1.115	0.553	0.046	0.058
ppnN; pyrimidine/purine-5’-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]	1.352	0.629	0.033	0.058
ppx-gppA; exopolyphosphatase / guanosine-5’-triphosphate,3’-diphosphate pyrophosphatase [EC:3.6.1.11 3.6.1.40]	1.115	0.553	0.046	0.058
PRDX2_4, ahpC; peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC:1.11.1.15]	1.115	0.553	0.046	0.058
prfA, MTRF1, MRF1; peptide chain release factor 1	1.115	0.553	0.046	0.058
prfB; peptide chain release factor 2	1.115	0.553	0.046	0.058
priA; primosomal protein N’ (replication factor Y) (superfamily II helicase) [EC:3.6.4.-]	1.115	0.553	0.046	0.058
prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]	1.115	0.553	0.046	0.058
proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	0.551	0.679	0.419	0.451
proB; glutamate 5-kinase [EC:2.7.2.11]	0.551	0.679	0.419	0.451
proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]	0.551	0.679	0.419	0.451
PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]	1.115	0.553	0.046	0.058
psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65]	1.115	0.553	0.046	0.058
pstA; phosphate transport system permease protein	-0.298	0.779	0.702	0.720
pstB; phosphate transport system ATP-binding protein [EC:3.6.3.27]	-0.298	0.779	0.702	0.720
pstC; phosphate transport system permease protein	-1.604	1.840	0.385	0.450
pstS; phosphate transport system substrate-binding protein	-0.298	0.779	0.702	0.720
PTH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]	1.115	0.553	0.046	0.058
PTS-Bgl-EIIC, bglF, bglP; PTS system, beta-glucoside-specific IIC component	1.359	0.653	0.039	0.058
PTS-Cel-EIIA, celC, chbA; PTS system, cellobiose-specific IIA component [EC:2.7.1.196 2.7.1.205]	0.551	0.679	0.419	0.451
PTS-Cel-EIIB, celA, chbB; PTS system, cellobiose-specific IIB component [EC:2.7.1.196 2.7.1.205]	0.551	0.679	0.419	0.451
PTS-Cel-EIIC, celB, chbC; PTS system, cellobiose-specific IIC component	0.551	0.679	0.419	0.451
PTS-Dgl-EIIC, gamP; PTS system, D-glucosamine-specific IIC component	-0.298	0.779	0.702	0.720
PTS-EI.PTSI, ptsI; phosphotransferase system, enzyme I, PtsI [EC:2.7.3.9]	1.078	0.528	0.043	0.058
PTS-Fru-EIIA, fruB; PTS system, fructose-specific IIA component [EC:2.7.1.202]	1.115	0.553	0.046	0.058
PTS-Fru-EIIC, fruA; PTS system, fructose-specific IIC component	0.945	0.526	0.074	0.090
PTS-Fru2-EIIB; PTS system, fructose-specific IIB-like component [EC:2.7.1.-]	-1.604	1.840	0.385	0.450
PTS-Gfr-EIIA, gfrA; PTS system, fructoselysine/glucoselysine-specific IIA component [EC:2.7.1.-]	1.359	0.653	0.039	0.058
PTS-Gfr-EIIB, gfrB; PTS system, fructoselysine/glucoselysine-specific IIB component [EC:2.7.1.-]	1.359	0.653	0.039	0.058
PTS-Gfr-EIIC, gfrC; PTS system, fructoselysine/glucoselysine-specific IIC component	1.359	0.653	0.039	0.058
PTS-Gfr-EIID, gfrD; PTS system, fructoselysine/glucoselysine-specific IID component	1.359	0.653	0.039	0.058
PTS-Glc-EIIA, crr; PTS system, sugar-specific IIA component [EC:2.7.1.-]	1.115	0.553	0.046	0.058
PTS-HPR.PTSH, ptsH; phosphocarrier protein HPr	1.115	0.553	0.046	0.058
PTS-HPR; phosphocarrier protein	1.115	0.553	0.046	0.058
PTS-MalGlc-EIIC, malX; PTS system, maltose/glucose-specific IIC component	0.001	0.653	0.999	0.999
PTS-Nag-EIIC, nagE; PTS system, N-acetylglucosamine-specific IIC component	1.115	0.553	0.046	0.058
PTS-Ntr-EIIA, ptsN; PTS system, nitrogen regulatory IIA component [EC:2.7.1.-]	1.096	0.540	0.044	0.058
PTS-Scr-EIIC, scrA, sacP, sacX, ptsS; PTS system, sucrose-specific IIC component	-0.298	0.779	0.702	0.720
PTS-Ula-EIIA, ulaC, sgaA; PTS system, ascorbate-specific IIA component [EC:2.7.1.194]	-1.604	1.840	0.385	0.450
PTS-Ula-EIIB, ulaB, sgaB; PTS system, ascorbate-specific IIB component [EC:2.7.1.194]	-1.604	1.840	0.385	0.450
PTS-Ula-EIIC, ulaA, sgaT; PTS system, ascorbate-specific IIC component	-1.604	1.840	0.385	0.450
purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4]	1.115	0.553	0.046	0.058
purB, ADSL; adenylosuccinate lyase [EC:4.3.2.2]	1.115	0.553	0.046	0.058
purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]	1.115	0.553	0.046	0.058
purD; phosphoribosylamine—glycine ligase [EC:6.3.4.13]	1.115	0.553	0.046	0.058
purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]	1.115	0.553	0.046	0.058
purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	1.115	0.553	0.046	0.058
purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]	1.115	0.553	0.046	0.058
purL, PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]	1.115	0.553	0.046	0.058
purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]	1.115	0.553	0.046	0.058
purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]	1.223	0.591	0.040	0.058
putP; sodium/proline symporter	1.115	0.553	0.046	0.058
PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	1.115	0.553	0.046	0.058
pyrB, PYR2; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]	1.115	0.553	0.046	0.058
pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14]	1.115	0.553	0.046	0.058
pyrDII; dihydroorotate dehydrogenase electron transfer subunit	1.115	0.553	0.046	0.058
pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10]	1.115	0.553	0.046	0.058
pyrF; orotidine-5’-phosphate decarboxylase [EC:4.1.1.23]	1.078	0.528	0.043	0.058
pyrG, CTPS; CTP synthase [EC:6.3.4.2]	0.551	0.679	0.419	0.451
pyrH; uridylate kinase [EC:2.7.4.22]	1.115	0.553	0.046	0.058
pyrP, uraA; uracil permease	1.115	0.553	0.046	0.058
pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9]	1.352	0.629	0.033	0.058
queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]	1.115	0.553	0.046	0.058
queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	0.551	0.679	0.419	0.451
queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]	-0.298	0.779	0.702	0.720
queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]	0.551	0.679	0.419	0.451
queH; epoxyqueuosine reductase [EC:1.17.99.6]	1.115	0.553	0.046	0.058
racD; aspartate racemase [EC:5.1.1.13]	1.219	0.577	0.036	0.058
radA, sms; DNA repair protein RadA/Sms	1.115	0.553	0.046	0.058
radC; DNA repair protein RadC	1.115	0.553	0.046	0.058
rapZ; RNase adapter protein RapZ	1.115	0.553	0.046	0.058
RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19]	1.115	0.553	0.046	0.058
rbfA; ribosome-binding factor A	1.115	0.553	0.046	0.058
rbgA; ribosome biogenesis GTPase A	1.115	0.553	0.046	0.058
rbsA; ribose transport system ATP-binding protein [EC:3.6.3.17]	0.551	0.679	0.419	0.451
rbsB; ribose transport system substrate-binding protein	0.551	0.679	0.419	0.451
rbsC; ribose transport system permease protein	0.551	0.679	0.419	0.451
rbsD; D-ribose pyranase [EC:5.4.99.62]	0.551	0.679	0.419	0.451
rbsK, RBKS; ribokinase [EC:2.7.1.15]	0.551	0.679	0.419	0.451
rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66]	-0.298	0.779	0.702	0.720
recA; recombination protein RecA	1.115	0.553	0.046	0.058
recF; DNA replication and repair protein RecF	1.115	0.553	0.046	0.058
recG; ATP-dependent DNA helicase RecG [EC:3.6.4.12]	1.129	0.564	0.047	0.060
recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]	1.115	0.553	0.046	0.058
recN; DNA repair protein RecN (Recombination protein N)	1.115	0.553	0.046	0.058
recO; DNA repair protein RecO (recombination protein O)	1.223	0.591	0.040	0.058
recQ; ATP-dependent DNA helicase RecQ [EC:3.6.4.12]	1.115	0.553	0.046	0.058
recR; recombination protein RecR	1.115	0.553	0.046	0.058
recT; recombination protein RecT	-1.604	1.840	0.385	0.450
recX; regulatory protein	1.115	0.553	0.046	0.058
relA; GTP pyrophosphokinase [EC:2.7.6.5]	1.115	0.553	0.046	0.058
relE, stbE; mRNA interferase RelE/StbE	1.282	0.604	0.035	0.058
res; type III restriction enzyme [EC:3.1.21.5]	0.915	0.466	0.051	0.064
rfbC, rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]	1.223	0.582	0.037	0.058
rfbD, rmlD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]	1.078	0.528	0.043	0.058
rho; transcription termination factor Rho	1.115	0.553	0.046	0.058
ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]	1.115	0.553	0.046	0.058
ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]	1.115	0.553	0.046	0.058
ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	1.115	0.553	0.046	0.058
ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]	1.115	0.553	0.046	0.058
ribH, RIB4; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]	1.115	0.553	0.046	0.058
ridA, tdcF, RIDA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10]	1.115	0.553	0.046	0.058
rimI; [ribosomal protein S18]-alanine N-acetyltransferase [EC:2.3.1.266]	1.115	0.553	0.046	0.058
rimJ; [ribosomal protein S5]-alanine N-acetyltransferase [EC:2.3.1.267]	1.355	0.641	0.036	0.058
rimM; 16S rRNA processing protein RimM	1.115	0.553	0.046	0.058
rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4]	-0.298	0.779	0.702	0.720
rimP; ribosome maturation factor RimP	1.115	0.553	0.046	0.058
rlmA1; 23S rRNA (guanine745-N1)-methyltransferase [EC:2.1.1.187]	0.551	0.679	0.419	0.451
rlmB; 23S rRNA (guanosine2251-2’-O)-methyltransferase [EC:2.1.1.185]	1.115	0.553	0.046	0.058
rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177]	1.115	0.553	0.046	0.058
rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191]	1.115	0.553	0.046	0.058
rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]	1.115	0.553	0.046	0.058
rlpA; rare lipoprotein A	-1.604	1.840	0.385	0.450
rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]	1.115	0.553	0.046	0.058
rluC; 23S rRNA pseudouridine955/2504/2580 synthase [EC:5.4.99.24]	1.115	0.553	0.046	0.058
rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]	1.115	0.553	0.046	0.058
rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3]	1.115	0.553	0.046	0.058
rnfA; electron transport complex protein RnfA	1.115	0.553	0.046	0.058
rnfC; electron transport complex protein RnfC	1.115	0.553	0.046	0.058
rnfD; electron transport complex protein RnfD	1.115	0.553	0.046	0.058
rnfE; electron transport complex protein RnfE	1.115	0.553	0.046	0.058
rnfG; electron transport complex protein RnfG	1.115	0.553	0.046	0.058
rng, cafA; ribonuclease G [EC:3.1.26.-]	1.115	0.553	0.046	0.058
rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4]	0.087	0.625	0.890	0.893
rnhB; ribonuclease HII [EC:3.1.26.4]	1.115	0.553	0.046	0.058
rnj; ribonuclease J [EC:3.1.-.-]	1.119	0.539	0.040	0.058
rnmV; ribonuclease M5 [EC:3.1.26.8]	1.115	0.553	0.046	0.058
rnpA; ribonuclease P protein component [EC:3.1.26.5]	1.115	0.553	0.046	0.058
rnr, vacB; ribonuclease R [EC:3.1.-.-]	1.115	0.553	0.046	0.058
rny; ribonucrease Y [EC:3.1.-.-]	1.115	0.553	0.046	0.058
rocR; arginine utilization regulatory protein	1.219	0.577	0.036	0.058
rodA, mrdB; rod shape determining protein RodA	1.115	0.553	0.046	0.058
RP-L1, MRPL1, rplA; large subunit ribosomal protein L1	1.115	0.553	0.046	0.058
RP-L10, MRPL10, rplJ; large subunit ribosomal protein L10	1.115	0.553	0.046	0.058
RP-L11, MRPL11, rplK; large subunit ribosomal protein L11	1.115	0.553	0.046	0.058
RP-L13, MRPL13, rplM; large subunit ribosomal protein L13	1.115	0.553	0.046	0.058
RP-L14, MRPL14, rplN; large subunit ribosomal protein L14	1.115	0.553	0.046	0.058
RP-L15, MRPL15, rplO; large subunit ribosomal protein L15	1.115	0.553	0.046	0.058
RP-L16, MRPL16, rplP; large subunit ribosomal protein L16	1.115	0.553	0.046	0.058
RP-L17, MRPL17, rplQ; large subunit ribosomal protein L17	1.115	0.553	0.046	0.058
RP-L18, MRPL18, rplR; large subunit ribosomal protein L18	1.115	0.553	0.046	0.058
RP-L19, MRPL19, rplS; large subunit ribosomal protein L19	1.115	0.553	0.046	0.058
RP-L2, MRPL2, rplB; large subunit ribosomal protein L2	1.115	0.553	0.046	0.058
RP-L20, MRPL20, rplT; large subunit ribosomal protein L20	1.115	0.553	0.046	0.058
RP-L21, MRPL21, rplU; large subunit ribosomal protein L21	1.115	0.553	0.046	0.058
RP-L22, MRPL22, rplV; large subunit ribosomal protein L22	1.115	0.553	0.046	0.058
RP-L23, MRPL23, rplW; large subunit ribosomal protein L23	1.115	0.553	0.046	0.058
RP-L24, MRPL24, rplX; large subunit ribosomal protein L24	1.115	0.553	0.046	0.058
RP-L27, MRPL27, rpmA; large subunit ribosomal protein L27	1.115	0.553	0.046	0.058
RP-L28, MRPL28, rpmB; large subunit ribosomal protein L28	1.115	0.553	0.046	0.058
RP-L29, rpmC; large subunit ribosomal protein L29	1.115	0.553	0.046	0.058
RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	1.115	0.553	0.046	0.058
RP-L30, MRPL30, rpmD; large subunit ribosomal protein L30	1.115	0.553	0.046	0.058
RP-L31, rpmE; large subunit ribosomal protein L31	1.115	0.553	0.046	0.058
RP-L32, MRPL32, rpmF; large subunit ribosomal protein L32	1.115	0.553	0.046	0.058
RP-L33, MRPL33, rpmG; large subunit ribosomal protein L33	1.115	0.553	0.046	0.058
RP-L34, MRPL34, rpmH; large subunit ribosomal protein L34	1.115	0.553	0.046	0.058
RP-L35, MRPL35, rpmI; large subunit ribosomal protein L35	1.115	0.553	0.046	0.058
RP-L36, MRPL36, rpmJ; large subunit ribosomal protein L36	1.115	0.553	0.046	0.058
RP-L4, MRPL4, rplD; large subunit ribosomal protein L4	1.115	0.553	0.046	0.058
RP-L5, MRPL5, rplE; large subunit ribosomal protein L5	1.115	0.553	0.046	0.058
RP-L6, MRPL6, rplF; large subunit ribosomal protein L6	1.115	0.553	0.046	0.058
RP-L7, MRPL12, rplL; large subunit ribosomal protein L7/L12	1.115	0.553	0.046	0.058
RP-L9, MRPL9, rplI; large subunit ribosomal protein L9	1.115	0.553	0.046	0.058
RP-S1, rpsA; small subunit ribosomal protein S1	-0.298	0.779	0.702	0.720
RP-S10, MRPS10, rpsJ; small subunit ribosomal protein S10	1.115	0.553	0.046	0.058
RP-S11, MRPS11, rpsK; small subunit ribosomal protein S11	1.115	0.553	0.046	0.058
RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12	1.115	0.553	0.046	0.058
RP-S13, rpsM; small subunit ribosomal protein S13	1.115	0.553	0.046	0.058
RP-S14, MRPS14, rpsN; small subunit ribosomal protein S14	1.115	0.553	0.046	0.058
RP-S15, MRPS15, rpsO; small subunit ribosomal protein S15	1.115	0.553	0.046	0.058
RP-S16, MRPS16, rpsP; small subunit ribosomal protein S16	1.115	0.553	0.046	0.058
RP-S17, MRPS17, rpsQ; small subunit ribosomal protein S17	1.115	0.553	0.046	0.058
RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18	1.115	0.553	0.046	0.058
RP-S19, rpsS; small subunit ribosomal protein S19	1.115	0.553	0.046	0.058
RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2	1.115	0.553	0.046	0.058
RP-S20, rpsT; small subunit ribosomal protein S20	1.115	0.553	0.046	0.058
RP-S3, rpsC; small subunit ribosomal protein S3	1.115	0.553	0.046	0.058
RP-S4, rpsD; small subunit ribosomal protein S4	1.115	0.553	0.046	0.058
RP-S5, MRPS5, rpsE; small subunit ribosomal protein S5	1.115	0.553	0.046	0.058
RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6	1.115	0.553	0.046	0.058
RP-S7, MRPS7, rpsG; small subunit ribosomal protein S7	1.115	0.553	0.046	0.058
RP-S8, rpsH; small subunit ribosomal protein S8	1.115	0.553	0.046	0.058
RP-S9, MRPS9, rpsI; small subunit ribosomal protein S9	1.115	0.553	0.046	0.058
rpe, RPE; ribulose-phosphate 3-epimerase [EC:5.1.3.1]	1.115	0.553	0.046	0.058
rph; ribonuclease PH [EC:2.7.7.56]	-0.298	0.779	0.702	0.720
rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6]	1.115	0.553	0.046	0.058
rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]	1.115	0.553	0.046	0.058
rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]	1.115	0.553	0.046	0.058
rpoC; DNA-directed RNA polymerase subunit beta’ [EC:2.7.7.6]	1.115	0.553	0.046	0.058
rpoD; RNA polymerase primary sigma factor	0.945	0.526	0.074	0.090
rpoE; DNA-directed RNA polymerase subunit delta	0.551	0.679	0.419	0.451
rpoE; RNA polymerase sigma-70 factor, ECF subfamily	1.115	0.553	0.046	0.058
rpoN; RNA polymerase sigma-54 factor	0.087	0.625	0.890	0.893
rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]	1.115	0.553	0.046	0.058
rsbU_P; phosphoserine phosphatase RsbU/P [EC:3.1.3.3]	1.115	0.553	0.046	0.058
rsbV; anti-sigma B factor antagonist	1.115	0.553	0.046	0.058
rsbW; serine/threonine-protein kinase RsbW [EC:2.7.11.1]	1.115	0.553	0.046	0.058
rseC; sigma-E factor negative regulatory protein RseC	1.115	0.553	0.046	0.058
rseP; regulator of sigma E protease [EC:3.4.24.-]	1.115	0.553	0.046	0.058
rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]	1.115	0.553	0.046	0.058
rsmB, sun; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]	1.115	0.553	0.046	0.058
rsmC; 16S rRNA (guanine1207-N2)-methyltransferase [EC:2.1.1.172]	1.115	0.553	0.046	0.058
rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]	1.115	0.553	0.046	0.058
rsmI; 16S rRNA (cytidine1402-2’-O)-methyltransferase [EC:2.1.1.198]	1.115	0.553	0.046	0.058
rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]	1.115	0.553	0.046	0.058
rtpR; ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2]	1.115	0.553	0.046	0.058
rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190]	1.115	0.553	0.046	0.058
rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.22.4]	1.219	0.577	0.036	0.058
ruvA; holliday junction DNA helicase RuvA [EC:3.6.4.12]	1.115	0.553	0.046	0.058
ruvB; holliday junction DNA helicase RuvB [EC:3.6.4.12]	1.115	0.553	0.046	0.058
ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4]	1.115	0.553	0.046	0.058
ruvX; putative holliday junction resolvase [EC:3.1.-.-]	1.115	0.553	0.046	0.058
SAM50, TOB55, bamA; outer membrane protein insertion porin family	1.115	0.553	0.046	0.058
SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11]	1.115	0.553	0.046	0.058
sauS; sulfoacetaldehyde dehydrogenase [EC:1.2.1.81]	1.359	0.653	0.039	0.058
sbcC, rad50; DNA repair protein SbcC/Rad50	1.115	0.553	0.046	0.058
scpA; segregation and condensation protein A	1.115	0.553	0.046	0.058
scpB; segregation and condensation protein B	1.115	0.553	0.046	0.058
sdhA, frdA; succinate dehydrogenase / fumarate reductase, flavoprotein subunit [EC:1.3.5.1 1.3.5.4]	0.551	0.679	0.419	0.451
secA; preprotein translocase subunit SecA	1.115	0.553	0.046	0.058
secB; preprotein translocase subunit SecB	1.219	0.577	0.036	0.058
secD; preprotein translocase subunit SecD	1.115	0.553	0.046	0.058
secE; preprotein translocase subunit SecE	1.115	0.553	0.046	0.058
secF; preprotein translocase subunit SecF	1.115	0.553	0.046	0.058
secG; preprotein translocase subunit SecG	1.115	0.553	0.046	0.058
secY; preprotein translocase subunit SecY	1.115	0.553	0.046	0.058
selA; L-seryl-tRNA(Ser) seleniumtransferase [EC:2.9.1.1]	0.551	0.679	0.419	0.451
selB, EEFSEC; selenocysteine-specific elongation factor	0.551	0.679	0.419	0.451
selD, SEPHS; selenide, water dikinase [EC:2.7.9.3]	0.551	0.679	0.419	0.451
selU; tRNA 2-selenouridine synthase [EC:2.9.1.-]	0.551	0.679	0.419	0.451
sepF; cell division inhibitor SepF	1.198	0.565	0.036	0.058
serA, PHGDH; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]	1.158	0.588	0.051	0.063
sfsA; sugar fermentation stimulation protein A	0.551	0.679	0.419	0.451
sigH; RNA polymerase sporulation-specific sigma factor	1.043	0.542	0.056	0.069
sir; sulfite reductase (ferredoxin) [EC:1.8.7.1]	1.219	0.577	0.036	0.058
slyD; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8]	1.115	0.553	0.046	0.058
smc; chromosome segregation protein	1.115	0.553	0.046	0.058
smf; DNA processing protein	1.136	0.569	0.048	0.061
smpB; SsrA-binding protein	1.115	0.553	0.046	0.058
speG, SAT; diamine N-acetyltransferase [EC:2.3.1.57]	1.359	0.653	0.039	0.058
splB; spore photoproduct lyase [EC:4.1.99.14]	1.115	0.553	0.046	0.058
spmA; spore maturation protein A	0.551	0.679	0.419	0.451
spoIID; stage II sporulation protein D	1.115	0.553	0.046	0.058
spoT; GTP diphosphokinase / guanosine-3’,5’-bis(diphosphate) 3’-diphosphatase [EC:2.7.6.5 3.1.7.2]	1.115	0.553	0.046	0.058
spoU; RNA methyltransferase, TrmH family	1.115	0.553	0.046	0.058
spoVG; stage V sporulation protein G	1.115	0.553	0.046	0.058
SPP; sucrose-6-phosphatase [EC:3.1.3.24]	0.876	0.520	0.094	0.114
sppA; protease IV [EC:3.4.21.-]	1.223	0.582	0.037	0.058
SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4]	1.115	0.553	0.046	0.058
ssb; single-strand DNA-binding protein	1.115	0.553	0.046	0.058
ssuA; sulfonate transport system substrate-binding protein	0.087	0.625	0.890	0.893
ssuB; sulfonate transport system ATP-binding protein [EC:3.6.3.-]	0.306	0.561	0.586	0.629
ssuC; sulfonate transport system permease protein	0.087	0.625	0.890	0.893
sulD; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:4.1.2.25 2.7.6.3]	1.115	0.553	0.046	0.058
tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]	0.802	0.500	0.111	0.131
tagD; glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39]	1.115	0.553	0.046	0.058
TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3]	1.115	0.553	0.046	0.058
tatD; TatD DNase family protein [EC:3.1.21.-]	1.115	0.553	0.046	0.058
TC.AGCS; alanine or glycine:cation symporter, AGCS family	1.122	0.558	0.046	0.059
TC.APA; basic amino acid/polyamine antiporter, APA family	0.087	0.625	0.890	0.893
TC.BAT1; bacterial/archaeal transporter family protein	0.802	0.500	0.111	0.131
TC.CITMHS; citrate-Mg2+:H+ or citrate-Ca2+:H+ symporter, CitMHS family	1.359	0.653	0.039	0.058
TC.FEV.OM; iron complex outermembrane recepter protein	1.190	0.575	0.040	0.058
TC.GNTP; gluconate:H+ symporter, GntP family	1.223	0.591	0.040	0.058
TC.GPH; glycoside/pentoside/hexuronide:cation symporter, GPH family	1.115	0.553	0.046	0.058
TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family	1.078	0.528	0.043	0.058
TC.LIVCS; branched-chain amino acid:cation transporter, LIVCS family	1.115	0.553	0.046	0.058
TC.NCS2; nucleobase:cation symporter-2, NCS2 family	-0.298	0.779	0.702	0.720
TC.NSS; neurotransmitter:Na+ symporter, NSS family	1.115	0.553	0.046	0.058
TC.OMF; outer membrane factor, OMF family	1.115	0.553	0.046	0.058
TC.OOP; OmpA-OmpF porin, OOP family	1.346	0.609	0.029	0.058
TC.SSS; solute:Na+ symporter, SSS family	-0.260	0.801	0.746	0.764
TC.ZIP, zupT, ZRT3, ZIP2; zinc transporter, ZIP family	0.551	0.679	0.419	0.451
tctA; putative tricarboxylic transport membrane protein	1.115	0.553	0.046	0.058
tctB; putative tricarboxylic transport membrane protein	1.158	0.588	0.051	0.063
tex; protein Tex	1.115	0.553	0.046	0.058
tgt, QTRT1; queuine tRNA-ribosyltransferase [EC:2.4.2.29]	1.115	0.553	0.046	0.058
thiB, tbpA; thiamine transport system substrate-binding protein	0.551	0.679	0.419	0.451
thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17]	1.115	0.553	0.046	0.058
thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7]	1.115	0.553	0.046	0.058
thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]	1.223	0.582	0.037	0.058
thiF; sulfur carrier protein ThiS adenylyltransferase [EC:2.7.7.73]	1.115	0.553	0.046	0.058
thiG; thiazole synthase [EC:2.8.1.10]	1.115	0.553	0.046	0.058
thiH; 2-iminoacetate synthase [EC:4.1.99.19]	0.945	0.526	0.074	0.090
thiJ; protein deglycase [EC:3.5.1.124]	1.115	0.553	0.046	0.058
thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2]	1.115	0.553	0.046	0.058
thiP; thiamine transport system permease protein	0.551	0.679	0.419	0.451
thiS; sulfur carrier protein	1.115	0.553	0.046	0.058
thrB1; homoserine kinase [EC:2.7.1.39]	-0.215	0.897	0.811	0.827
thrB2; homoserine kinase type II [EC:2.7.1.39]	1.289	0.586	0.029	0.058
thrC; threonine synthase [EC:4.2.3.1]	0.087	0.625	0.890	0.893
thyA, TYMS; thymidylate synthase [EC:2.1.1.45]	1.115	0.553	0.046	0.058
tig; trigger factor	1.115	0.553	0.046	0.058
tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]	1.115	0.553	0.046	0.058
tlyA; 23S rRNA (cytidine1920-2’-O)/16S rRNA (cytidine1409-2’-O)-methyltransferase [EC:2.1.1.226 2.1.1.227]	1.115	0.553	0.046	0.058
tlyC; putative hemolysin	1.115	0.553	0.046	0.058
tmk, DTYMK; dTMP kinase [EC:2.7.4.9]	1.115	0.553	0.046	0.058
tnaA; tryptophanase [EC:4.1.99.1]	1.286	0.569	0.025	0.058
tonB; periplasmic protein TonB	1.115	0.553	0.046	0.058
topA; DNA topoisomerase I [EC:5.99.1.2]	1.115	0.553	0.046	0.058
topB; DNA topoisomerase III [EC:5.99.1.2]	1.219	0.577	0.036	0.058
TPI, tpiA; triosephosphate isomerase (TIM) [EC:5.3.1.1]	1.115	0.553	0.046	0.058
trbL; type IV secretion system protein TrbL	1.219	0.577	0.036	0.058
trkA, ktrA; trk system potassium uptake protein	1.115	0.553	0.046	0.058
trkH, trkG, ktrB; trk system potassium uptake protein	1.115	0.553	0.046	0.058
trmB, METTL1; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]	1.078	0.528	0.043	0.058
trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]	1.115	0.553	0.046	0.058
trmFO, gid; methylenetetrahydrofolate–tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]	1.115	0.553	0.046	0.058
trmL, cspR; tRNA (cytidine/uridine-2’-O-)-methyltransferase [EC:2.1.1.207]	1.115	0.553	0.046	0.058
troA, mntA, znuA; manganese/zinc/iron transport system substrate-binding protein	1.352	0.629	0.033	0.058
troB, mntB, znuC; manganese/zinc/iron transport system ATP- binding protein	1.352	0.629	0.033	0.058
troC, mntC, znuB; manganese/zinc/iron transport system permease protein	1.352	0.629	0.033	0.058
troD, mntD, znuB; manganese/zinc/iron transport system permease protein	1.352	0.629	0.033	0.058
trpB; tryptophan synthase beta chain [EC:4.2.1.20]	1.352	0.629	0.033	0.058
truA, PUS1; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]	1.115	0.553	0.046	0.058
truB, PUS4, TRUB1; tRNA pseudouridine55 synthase [EC:5.4.99.25]	1.115	0.553	0.046	0.058
trxA; thioredoxin 1	0.945	0.526	0.074	0.090
trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9]	1.115	0.553	0.046	0.058
tsaC, rimN, SUA5; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]	1.115	0.553	0.046	0.058
tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE	1.115	0.553	0.046	0.058
tsf, TSFM; elongation factor Ts	1.115	0.553	0.046	0.058
tuf, TUFM; elongation factor Tu	0.970	0.550	0.080	0.096
typA, bipA; GTP-binding protein	1.115	0.553	0.046	0.058
tyrB; aromatic-amino-acid transaminase [EC:2.6.1.57]	1.115	0.553	0.046	0.058
ubiB, aarF; ubiquinone biosynthesis protein	0.551	0.679	0.419	0.451
ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	1.359	0.653	0.039	0.058
udk, UCK; uridine kinase [EC:2.7.1.48]	-0.298	0.779	0.702	0.720
udp, UPP; uridine phosphorylase [EC:2.4.2.3]	-1.604	1.840	0.385	0.450
UGCG; ceramide glucosyltransferase [EC:2.4.1.80]	1.352	0.629	0.033	0.058
UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	0.551	0.679	0.419	0.451
UGP2, galU, galF; UTP–glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]	1.115	0.553	0.046	0.058
UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27]	1.115	0.553	0.046	0.058
upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9]	1.115	0.553	0.046	0.058
uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]	1.115	0.553	0.046	0.058
URA4, pyrC; dihydroorotase [EC:3.5.2.3]	1.115	0.553	0.046	0.058
urdA; urocanate reductase [EC:1.3.99.33]	0.551	0.679	0.419	0.451
uvrA; excinuclease ABC subunit A	1.115	0.553	0.046	0.058
uvrB; excinuclease ABC subunit B	1.115	0.553	0.046	0.058
uvrC; excinuclease ABC subunit C	1.115	0.553	0.046	0.058
uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12]	1.096	0.540	0.044	0.058
VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9]	1.115	0.553	0.046	0.058
virB10, lvhB10; type IV secretion system protein VirB10	1.219	0.577	0.036	0.058
virB11, lvhB11; type IV secretion system protein VirB11	1.219	0.577	0.036	0.058
virB4, lvhB4; type IV secretion system protein VirB4	1.219	0.577	0.036	0.058
virB5, lvhB5; type IV secretion system protein VirB5	1.219	0.577	0.036	0.058
virB9, lvhB9; type IV secretion system protein VirB9	1.219	0.577	0.036	0.058
virD4, lvhD4; type IV secretion system protein VirD4	1.219	0.577	0.036	0.058
virK; uncharacterized protein	-0.298	0.779	0.702	0.720
waaF, rfaF; heptosyltransferase II [EC:2.4.-.-]	1.117	0.546	0.042	0.058
waaL, rfaL; O-antigen ligase [EC:2.4.1.-]	1.352	0.629	0.033	0.058
waaY, rfaY; heptose II phosphotransferase [EC:2.7.1.-]	1.198	0.565	0.036	0.058
WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]	1.115	0.553	0.046	0.058
wbjC; UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase [EC:1.1.1.367]	1.219	0.577	0.036	0.058
wbpO; UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.-]	1.359	0.653	0.039	0.058
wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14]	0.802	0.500	0.111	0.131
xdhC; xanthine dehydrogenase accessory factor	0.551	0.679	0.419	0.451
xerC; integrase/recombinase XerC	0.802	0.500	0.111	0.131
xerD; integrase/recombinase XerD	1.115	0.553	0.046	0.058
xlyAB; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	1.352	0.629	0.033	0.058
xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22]	-0.298	0.779	0.702	0.720
xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]	1.223	0.582	0.037	0.058
xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]	1.115	0.553	0.046	0.058
xtmA; phage terminase small subunit	-1.604	1.840	0.385	0.450
xtmB; phage terminase large subunit	1.219	0.577	0.036	0.058
yabN; tetrapyrrole methylase family protein / MazG family protein	0.551	0.679	0.419	0.451
yaeR; glyoxylase I family protein	0.551	0.679	0.419	0.451
yajC; preprotein translocase subunit YajC	1.115	0.553	0.046	0.058
YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1]	1.115	0.553	0.046	0.058
ybaK, ebsC; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]	1.115	0.553	0.046	0.058
ybcJ; ribosome-associated protein	1.115	0.553	0.046	0.058
ybeY, yqfG; probable rRNA maturation factor	1.115	0.553	0.046	0.058
ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-]	1.115	0.553	0.046	0.058
ybjD; putative ATP-dependent endonuclease of the OLD family	1.115	0.553	0.046	0.058
ycaJ; putative ATPase	1.115	0.553	0.046	0.058
ycdX; putative hydrolase	0.551	0.679	0.419	0.451
ychF; ribosome-binding ATPase	1.115	0.553	0.046	0.058
yefM; antitoxin YefM	1.219	0.577	0.036	0.058
yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]	1.289	0.586	0.029	0.058
yesN; two-component system, response regulator YesN	1.115	0.553	0.046	0.058
yfbK; Ca-activated chloride channel homolog	1.235	0.555	0.027	0.058
yfiH; polyphenol oxidase [EC:1.10.3.-]	1.115	0.553	0.046	0.058
yggS, PROSC; PLP dependent protein	1.115	0.553	0.046	0.058
yggT; YggT family protein	1.115	0.553	0.046	0.058
yhbH; putative sigma-54 modulation protein	1.115	0.553	0.046	0.058
yhbY; RNA-binding protein	1.115	0.553	0.046	0.058
yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase	1.115	0.553	0.046	0.058
yjbB; phosphate:Na+ symporter	1.115	0.553	0.046	0.058
ylxR; uncharacterized protein	1.115	0.553	0.046	0.058
yoeB; toxin YoeB [EC:3.1.-.-]	1.352	0.629	0.033	0.058
ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-]	0.087	0.625	0.890	0.893
yqeH; 30S ribosome assembly GTPase	1.115	0.553	0.046	0.058
yraN; putative endonuclease	1.115	0.553	0.046	0.058
ysxB; uncharacterized protein	1.115	0.553	0.046	0.058
ytmI; uncharacterized N-acetyltransferase [EC:2.3.1.-]	1.264	0.600	0.037	0.058
yuiF; putative amino acid transporter	1.223	0.591	0.040	0.058
zntA; Cd2+/Zn2+-exporting ATPase [EC:3.6.3.3 3.6.3.5]	1.115	0.553	0.046	0.058
znuA; zinc transport system substrate-binding protein	1.136	0.569	0.048	0.061
znuB; zinc transport system permease protein	1.115	0.553	0.046	0.058
znuC; zinc transport system ATP-binding protein [EC:3.6.3.-]	1.115	0.553	0.046	0.058

# merge with tb.ra for full results table
full.res <- left_join(tb.ra, results.out, by = "description")

write.csv(full.res, "output/picrust_ko_stratefied_fuso_data_results.csv", row.names = F)

Session information

sessionInfo()

R version 4.0.5 (2021-03-31)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19042)

Matrix products: default

locale:
[1] LC_COLLATE=English_United States.1252 
[2] LC_CTYPE=English_United States.1252   
[3] LC_MONETARY=English_United States.1252
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.1252    

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] cowplot_1.1.1     dendextend_1.14.0 ggdendro_0.1.22   reshape2_1.4.4   
 [5] car_3.0-10        carData_3.0-4     gvlma_1.0.0.3     patchwork_1.1.1  
 [9] viridis_0.5.1     viridisLite_0.3.0 gridExtra_2.3     xtable_1.8-4     
[13] kableExtra_1.3.4  MASS_7.3-53.1     data.table_1.14.0 readxl_1.3.1     
[17] forcats_0.5.1     stringr_1.4.0     dplyr_1.0.5       purrr_0.3.4      
[21] readr_1.4.0       tidyr_1.1.3       tibble_3.1.0      ggplot2_3.3.3    
[25] tidyverse_1.3.0   lmerTest_3.1-3    lme4_1.1-26       Matrix_1.3-2     
[29] vegan_2.5-7       lattice_0.20-41   permute_0.9-5     phyloseq_1.34.0  
[33] workflowr_1.6.2  

loaded via a namespace (and not attached):
  [1] minqa_1.2.4         colorspace_2.0-0    rio_0.5.26         
  [4] ellipsis_0.3.1      rprojroot_2.0.2     XVector_0.30.0     
  [7] fs_1.5.0            rstudioapi_0.13     farver_2.1.0       
 [10] fansi_0.4.2         lubridate_1.7.10    xml2_1.3.2         
 [13] codetools_0.2-18    splines_4.0.5       knitr_1.31         
 [16] ade4_1.7-16         jsonlite_1.7.2      nloptr_1.2.2.2     
 [19] broom_0.7.5         cluster_2.1.1       dbplyr_2.1.0       
 [22] BiocManager_1.30.10 compiler_4.0.5      httr_1.4.2         
 [25] backports_1.2.1     assertthat_0.2.1    cli_2.3.1          
 [28] later_1.1.0.1       htmltools_0.5.1.1   prettyunits_1.1.1  
 [31] tools_4.0.5         igraph_1.2.6        gtable_0.3.0       
 [34] glue_1.4.2          Rcpp_1.0.6          Biobase_2.50.0     
 [37] cellranger_1.1.0    jquerylib_0.1.3     vctrs_0.3.6        
 [40] Biostrings_2.58.0   rhdf5filters_1.2.0  multtest_2.46.0    
 [43] svglite_2.0.0       ape_5.4-1           nlme_3.1-152       
 [46] iterators_1.0.13    xfun_0.21           ps_1.6.0           
 [49] openxlsx_4.2.3      rvest_1.0.0         lifecycle_1.0.0    
 [52] statmod_1.4.35      zlibbioc_1.36.0     scales_1.1.1       
 [55] hms_1.0.0           promises_1.2.0.1    parallel_4.0.5     
 [58] biomformat_1.18.0   rhdf5_2.34.0        curl_4.3           
 [61] yaml_2.2.1          sass_0.3.1          stringi_1.5.3      
 [64] highr_0.8           S4Vectors_0.28.1    foreach_1.5.1      
 [67] BiocGenerics_0.36.0 zip_2.1.1           boot_1.3-27        
 [70] systemfonts_1.0.1   rlang_0.4.10        pkgconfig_2.0.3    
 [73] evaluate_0.14       Rhdf5lib_1.12.1     labeling_0.4.2     
 [76] tidyselect_1.1.0    plyr_1.8.6          magrittr_2.0.1     
 [79] R6_2.5.0            IRanges_2.24.1      generics_0.1.0     
 [82] DBI_1.1.1           foreign_0.8-81      pillar_1.5.1       
 [85] haven_2.3.1         withr_2.4.1         mgcv_1.8-34        
 [88] abind_1.4-5         survival_3.2-10     modelr_0.1.8       
 [91] crayon_1.4.1        utf8_1.1.4          rmarkdown_2.7      
 [94] progress_1.2.2      grid_4.0.5          git2r_0.28.0       
 [97] webshot_0.5.2       reprex_1.0.0        digest_0.6.27      
[100] httpuv_1.5.5        numDeriv_2016.8-1.1 stats4_4.0.5       
[103] munsell_0.5.0       bslib_0.2.4