- Statistical analysis
- Which genes are differentially regualted upon KO of DEPDC5
- Modelling the KO in all different combinations
- KO effect in noDIFF noRAPA
- D62
- KO effect in DIFF noRAPA
- D62
- KO effect in noDIFF RAPA
- D62
- KO effect in DIFF RAPA
- D62
Statistical analysis
AGC, AY
23 3 2021
Last updated: 2022-08-18
Checks: 6 1
Knit directory:
S:/KJP_Biolabor/Projects/CePTER/DEPDC5_D62_Analysis/
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home = getwd()Statistical analysis
Which genes are differentially regualted upon KO of DEPDC5
Modelling the KO in all different combinations
if(reanalyze | !file.exists(paste0(home,"/output/D62_ResTabs_KO.RData"))){
# calculate all combinations
Rapamycin=c("noRAPA", "RAPA")
Differentiation=c("noDIFF", "DIFF")
Type_sgRNA<-list(c("sgNTC","sg2.1"),c("sgNTC","sg2.2"))
target="KO"
Cl="D62"
# no random effects included
for(r in Rapamycin){
Rapafilter = SampleInfo$RAPA %in% r
for(d in Differentiation){
Difffilter = SampleInfo$DIFF %in% d
for(Tp in Type_sgRNA){
sgRNAfilter = SampleInfo$gRNA %in% Tp
vs_label=paste0(Tp, sep="", collapse="_")
Set = rownames(SampleInfo)[Rapafilter&Difffilter&
sgRNAfilter]
lab = paste("restab", Cl, vs_label, d,r, sep="_")
print(lab)
assign(lab,
comparison(ddsMat, samples = Set,
target =target,randomeffect = c()))
}
}
}
comparisons= apropos("restab")
save(list = comparisons, file = paste0(home,"/output/D62_ResTabs_KO.RData"))
} else
load(file = paste0(home,"/output/D62_ResTabs_KO.RData"))[1] "restab_D62_sgNTC_sg2.1_noDIFF_noRAPA"
[1] "restab_D62_sgNTC_sg2.2_noDIFF_noRAPA"
[1] "restab_D62_sgNTC_sg2.1_DIFF_noRAPA"
[1] "restab_D62_sgNTC_sg2.2_DIFF_noRAPA"
[1] "restab_D62_sgNTC_sg2.1_noDIFF_RAPA"
[1] "restab_D62_sgNTC_sg2.2_noDIFF_RAPA"
[1] "restab_D62_sgNTC_sg2.1_DIFF_RAPA"
[1] "restab_D62_sgNTC_sg2.2_DIFF_RAPA"samesign <- function(x) {abs(sum(sign(x)))==length(x)}
mypval=0.05
colors <- rev(colorRampPalette(brewer.pal(9, "Spectral"))(255))
genelists=lapply(list.files(paste0(home,"/data/genelists_to_test"), full.names = T),
function(x){read.table(x, header=T)})
names(genelists) = gsub(".txt", "", list.files(paste0(home,"/data/genelists_to_test")))
geneids=rownames(restab_D62_sgNTC_sg2.1_noDIFF_noRAPA)
getlinmodoutput = function(targetline="D62",
targetdiff,
targetrapa){
samplesincl = SampleInfo$DIFF==targetdiff &
SampleInfo$RAPA==targetrapa &
SampleInfo$CellLine== targetline
pvalrep= get(paste0("restab_",
targetline, "_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$padj<mypval &
get(paste0("restab_",
targetline, "_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$padj<mypval
betarep = apply(cbind(get(paste0("restab_",
targetline, "_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$log2FoldChange,
get(paste0("restab_",
targetline, "_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$log2FoldChange), 1,
samesign)
idx=which(betarep & pvalrep)
hits=geneids[idx]
restab=data.frame(
entrezgene = geneids[idx],
genname=rowData(ddsMat)[hits,"hgnc"],
log2FC_2.1 = get(paste0("restab_",
targetline, "_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$log2FoldChange[idx],
fdr_2.1 = get(paste0("restab_",
targetline, "_sgNTC_sg2.1_",
targetdiff, "_" ,
targetrapa))$padj[idx],
log2FC_2.2 = get(paste0("restab_",
targetline, "_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$log2FoldChange[idx],
fdr_2.2 = get(paste0("restab_",
targetline, "_sgNTC_sg2.2_",
targetdiff, "_" ,
targetrapa))$padj[idx])
print(restab)
write.xlsx(restab, file=paste0(output, "/Restab_",
targetline,"_",
targetdiff, "_",
targetrapa, ".xlsx"))
SamplesSet=SampleInfo[samplesincl,]
plotmatrix = log_2cpm[hits,rownames(SamplesSet)]
rownames(SamplesSet)=SamplesSet$label_rep
colnames(plotmatrix)=SamplesSet$label_rep
rownames(plotmatrix)=rowData(ddsMat)[hits,"hgnc"]
cellcol = Dark8[1:nlevels(SampleInfo$CellLine)]
names(cellcol) = levels(SampleInfo$CellLine)
cellcol = cellcol[as.character(unique(SamplesSet$CellLine))]
gRNAcol = Dark8[c(1:nlevels(SampleInfo$gRNA))+nlevels(SampleInfo$CellLine)]
names(gRNAcol) = levels(SampleInfo$gRNA)
gRNAcol = gRNAcol[as.character(unique(SamplesSet$gRNA))]
diffcol = brewer.pal(3,"Set1")[1:nlevels(SampleInfo$DIFF)]
names(diffcol) = levels(SampleInfo$DIFF)
diffcol = diffcol[as.character(unique(SamplesSet$DIFF))]
rapacol = brewer.pal(3,"Set2")[1:nlevels(SampleInfo$RAPA)]
names(rapacol) = levels(SampleInfo$RAPA)
rapacol = rapacol[as.character(unique(SamplesSet$RAPA))]
ann_colors = list(
DIFF = diffcol,
RAPA = rapacol,
gRNA = gRNAcol,
CellLine=cellcol)
collabels = SamplesSet[,c("CellLine","DIFF","RAPA", "gRNA")] %>%
mutate_all(as.character) %>% as.data.frame()
rownames(collabels)=SamplesSet$label_rep
idx=order(SamplesSet$gRNA)
pheatmap(plotmatrix[,idx],
border_color = NA,
annotation_col = collabels[idx,],show_rownames = F, show_colnames = F,
annotation_colors = ann_colors,
clustering_method = "ward.D2",
cluster_cols = F,
col = colors,
scale = "row",
main = paste("Normalized log2 counts", targetline, targetdiff, targetrapa))
gene_univers = rownames(ddsMat)
gostres = getGOresults(hits, gene_univers)
toptab = gostres$result
write.xlsx(toptab, file = paste0(output, "/GOres_",targetline,targetdiff,targetrapa,".xlsx"), sheetName = "GO_enrichment")
idx = grepl("GO|KEGG", toptab$source)
titlename = paste(targetline,targetdiff,targetrapa)
if(!any(idx)){
p = ggplot() + annotate("text", x = 4, y = 25, size=4,
label = "no significant GO term") +
ggtitle(titlename)+theme_void()+
theme(plot.title = element_text(hjust = 0.5))
} else {
p=GOplot(toptab[idx, ], 10, Title = titlename)
}
print(p)
## enrichment test for genelist
Resall=data.frame()
for (gl in names(genelists)){
tmp=table(signif=geneids %in% hits, targetgene=geneids %in% genelists[[gl]]$ENTREZ_ID)
resfish=fisher.test(tmp)
res = c(resfish$estimate, unlist(resfish$conf.int), resfish$p.value)
Resall = rbind(Resall, res)
}
colnames(Resall)=c("OR", "CI95L", "CI95U", "P")
rownames(Resall)=names(genelists)
Resall$Beta = log(Resall$OR)
Resall$SE = (log(Resall$OR)-log(Resall$CI95L))/1.96
Resall$Padj=p.adjust(Resall$P, method = "bonferroni")
print(Resall)
multiORplot(Resall, Pval = "P", Padj = "Padj", beta="Beta",SE = "SE",
pheno=paste(targetline, targetdiff, targetrapa))
}
geneids=rownames(restab_D62_sgNTC_sg2.1_noDIFF_noRAPA)KO effect in noDIFF noRAPA
D62
getlinmodoutput(targetline = "D62",targetdiff = "noDIFF",targetrapa = "noRAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 64856 VWA1 1.0892844 3.075562e-12 0.7285097 3.335990e-06
2 26038 CHD5 2.6315908 1.417316e-07 1.4609239 1.668736e-02
3 3925 STMN1 -0.8131038 6.841853e-11 -0.4047316 1.617550e-04
4 90853 SPOCD1 1.5410330 1.306139e-05 0.9545620 4.769198e-02
5 23499 MACF1 0.3837815 4.965528e-02 0.3341228 2.673200e-02
6 59269 HIVEP3 0.8406193 5.691220e-03 0.7731647 8.991416e-04
7 11004 KIF2C -1.4716331 3.774881e-06 -1.2753566 6.553854e-08
8 5052 PRDX1 -0.5761057 1.440015e-09 -0.4282492 7.515508e-09
9 9077 DIRAS3 1.8022491 1.054607e-14 1.5352770 9.581298e-21
10 81849 ST6GALNAC5 -0.7856164 1.709336e-10 -0.4114943 1.159554e-05
11 64123 ADGRL4 1.3768823 1.525051e-03 1.8273933 5.105453e-10
12 2633 GBP1 4.3457775 1.595376e-04 4.0102130 9.650536e-05
13 84722 PSRC1 -0.4534422 9.730923e-04 -0.3020121 9.492045e-03
14 3321 IGSF3 -0.8433839 9.585479e-04 -0.5473542 6.989319e-03
15 10628 TXNIP -1.3810106 4.071429e-05 -1.1473212 4.686387e-07
16 140576 S100A16 0.8919626 1.093717e-09 0.3317805 4.172758e-02
17 10763 NES 0.7606565 1.467078e-13 0.4262272 8.725999e-07
18 57863 CADM3 -2.0260731 1.510930e-03 -1.0777568 3.583125e-02
19 400793 C1orf226 0.8127671 6.400278e-03 0.6002242 2.740678e-02
20 4921 DDR2 -0.8525309 3.949671e-02 -0.8846002 8.610829e-04
21 5999 RGS4 2.1857048 4.032092e-08 2.0257520 1.248142e-07
22 6004 RGS16 1.3232831 2.664105e-11 0.5609847 2.313075e-02
23 64710 NUCKS1 -0.4835910 2.329196e-06 -0.2913098 1.451638e-03
24 1063 CENPF -1.1466949 3.266629e-13 -0.4548584 2.238609e-04
25 149111 CNIH3 1.0690978 4.325986e-03 1.0625651 4.806234e-04
26 84886 C1orf198 0.5484394 3.527610e-02 0.5158203 2.465076e-02
27 4811 NID1 -1.5129348 2.124236e-03 -1.0116004 2.309960e-02
28 22944 KIN -2.0055566 5.757344e-04 -1.1838012 1.061975e-02
29 5660 PSAP 0.7111062 4.410466e-20 0.1798656 8.451417e-03
30 54541 DDIT4 1.0557531 3.490589e-03 0.8450571 2.198764e-02
31 5328 PLAU 1.2384477 1.577948e-02 1.0758169 3.641623e-02
32 84858 <NA> 1.8245316 4.091039e-04 1.5504984 1.376196e-03
33 3988 LIPA 1.0234270 1.371967e-04 0.6509579 3.729125e-02
34 143282 FGFBP3 0.6243988 2.721432e-04 0.4629851 4.527298e-03
35 26509 MYOF 1.7145925 3.329288e-02 2.0874494 1.456812e-03
36 9124 PDLIM1 1.1001337 7.354962e-04 1.1004307 2.870465e-06
37 83742 MARVELD1 -0.8431712 1.326637e-02 -0.6517105 3.315254e-02
38 6319 SCD 0.5331130 1.645543e-05 0.3371696 1.108394e-03
39 6468 FBXW4 1.1779903 1.481301e-03 0.7718936 3.641623e-02
40 259217 HSPA12A 1.8421463 3.370295e-03 1.6193468 2.292344e-02
41 642938 INSYN2A 0.4027642 4.015934e-02 0.7777285 6.605916e-10
42 4288 MKI67 -1.0123111 1.442152e-06 -0.5893857 5.819468e-03
43 977 CD151 1.2635289 3.728768e-27 0.3295937 9.815768e-03
44 6240 RRM1 -0.8816314 1.153480e-02 -1.0401431 1.908546e-04
45 4004 LMO1 -2.3567118 2.079132e-07 -2.7131580 1.254653e-21
46 10553 HTATIP2 1.9333095 1.690227e-02 2.0019304 5.655760e-04
47 5080 PAX6 -0.9181084 1.019508e-02 -0.8147835 2.564557e-03
48 960 CD44 1.4591708 9.338179e-16 1.1683319 1.210130e-15
49 79026 AHNAK 1.5851868 1.544050e-09 0.9169080 4.768239e-04
50 1717 DHCR7 0.7307510 3.188177e-04 0.3960401 3.001859e-02
51 26011 TENM4 1.7246307 2.481137e-02 1.5154269 4.675757e-02
52 11098 PRSS23 0.8798684 1.960728e-02 0.9004492 3.761899e-04
53 1410 CRYAB 1.1173770 3.476939e-12 0.5931808 1.088950e-04
54 6876 TAGLN 0.6543144 1.983800e-13 0.3420865 6.018107e-08
55 1656 DDX6 -0.4617054 2.166969e-02 -0.3694408 5.537409e-03
56 2012 EMP1 0.6479519 1.563592e-02 1.1887114 1.119352e-12
57 196410 METTL7B 1.5599602 3.020553e-12 0.7182732 2.255546e-03
58 967 CD63 0.9019072 3.851593e-39 0.2540967 1.196946e-05
59 4035 LRP1 0.6449247 4.076243e-05 0.5918438 1.866013e-07
60 4193 MDM2 0.6719346 3.844160e-05 0.3615605 1.262560e-02
61 160335 TMTC2 -1.6135376 6.014427e-06 -1.0544925 1.724845e-04
62 490 ATP2B1 -0.7878372 1.474724e-03 -0.6061956 4.808735e-04
63 5829 PXN 0.7640621 4.062369e-04 0.5820746 7.936104e-03
64 3146 HMGB1 -0.7285274 5.966944e-16 -0.3215517 6.194211e-07
65 8848 TSC22D1 0.5613517 5.123576e-04 0.6635049 1.163073e-11
66 8660 IRS2 0.4101733 2.430542e-05 0.2984944 4.872851e-04
67 28526 <NA> 1.9278887 1.741341e-07 1.9178656 1.968941e-11
68 54916 TMEM260 -1.0306993 3.988816e-02 -0.9104398 3.976121e-02
69 57570 TRMT5 -0.6824356 9.703832e-05 -0.3831739 6.823688e-03
70 23224 SYNE2 -1.3811382 1.909678e-06 -0.7362985 6.120540e-05
71 64093 SMOC1 0.7201019 1.536550e-07 0.3597993 9.699354e-04
72 9369 NRXN3 -1.7174772 2.192983e-05 -1.0877059 8.093515e-04
73 55384 MEG3 1.6246309 6.353745e-22 1.1918119 3.931182e-15
74 113146 AHNAK2 2.2298981 1.100829e-04 2.6577306 1.642724e-14
75 11245 GPR176 2.1616993 3.793467e-03 2.0977492 1.717827e-03
76 90417 KNSTRN -1.3213590 3.768730e-03 -0.8170137 4.172758e-02
77 51203 NUSAP1 -1.3682393 1.819314e-06 -0.5193085 8.702281e-03
78 2628 GATM 0.6525196 3.474952e-02 1.0416366 7.594344e-12
79 302 ANXA2 0.3964197 1.975148e-04 0.2995517 1.056447e-02
80 7168 TPM1 0.5163549 2.189321e-02 0.4713141 1.858398e-03
81 9768 PCLAF -1.6192503 6.619244e-04 -1.0918606 3.178054e-03
82 3671 ISLR 1.4582038 7.636745e-08 0.8562869 9.938267e-04
83 23205 ACSBG1 0.6910217 1.265573e-02 0.5922977 3.041423e-02
84 9055 PRC1 -0.7454089 1.738144e-02 -0.5070052 4.882398e-02
85 56963 RGMA 1.6179562 2.570150e-22 0.7273235 5.283814e-07
86 23336 SYNM 0.7053394 8.114026e-05 0.7285223 3.606306e-08
87 51330 TNFRSF12A 1.4059052 4.373945e-20 0.9554401 6.348958e-16
88 2013 EMP2 -0.7546354 7.607574e-05 -0.4966014 7.060439e-03
89 26471 NUPR1 2.3612545 1.870745e-12 1.0657975 2.418253e-02
90 4313 MMP2 0.8703997 3.440811e-09 0.4221113 6.487195e-03
91 6376 CX3CL1 0.8954558 1.512042e-03 0.5519566 1.955410e-02
92 794 CALB2 -4.6167606 1.822472e-06 -2.1172122 2.112181e-03
93 23406 COTL1 0.7992038 1.400921e-09 0.4700650 1.672984e-06
94 79007 DBNDD1 1.9205874 2.565613e-24 0.6772243 1.108394e-03
95 9212 AURKB -1.2399686 2.287452e-03 -1.1963693 1.632320e-03
96 9423 NTN1 1.4854613 2.618750e-12 0.6558489 6.669248e-03
97 9953 <NA> -0.7862300 1.911337e-04 -0.4187471 7.670737e-03
98 5376 PMP22 0.5572320 3.108196e-03 0.4802813 1.670511e-03
99 125144 SNHG29 -0.5331262 6.565905e-03 -0.2835938 2.475929e-02
100 7153 TOP2A -0.9721903 1.993781e-11 -0.8239175 1.222927e-15
101 284119 CAVIN1 1.0611724 1.125087e-04 0.6185919 4.656529e-02
102 2670 GFAP 1.0690762 1.553293e-30 0.2604783 4.641576e-03
103 6426 SRSF1 -0.9521000 2.684500e-06 -0.5783965 6.608999e-04
104 54549 SDK2 -0.9445922 4.684966e-02 -0.8412877 4.125061e-02
105 283991 <NA> 0.5569752 3.228727e-05 0.3796500 4.175454e-03
106 332 BIRC5 -1.2781479 4.572826e-04 -0.7416046 8.606921e-04
107 284184 NDUFAF8 0.8494269 4.400209e-12 0.3473532 8.122019e-03
108 11031 RAB31 0.3245603 2.321577e-03 0.2509527 1.338585e-02
109 1000 CDH2 0.2478272 2.666336e-02 0.3194867 5.502703e-08
110 115106 <NA> -1.6973970 1.660721e-03 -0.9655808 8.649361e-03
111 4645 MYO5B -1.4814373 9.958677e-03 -0.8092195 3.583125e-02
112 5596 MAPK4 -1.1639881 3.998119e-03 -0.9126168 1.983599e-02
113 976 ADGRE5 1.5563103 2.052428e-10 0.9699747 2.475935e-04
114 9518 GDF15 1.7737014 2.565613e-24 0.9110701 2.968916e-08
115 348 APOE 2.0368060 6.914417e-20 1.2379642 7.171243e-11
116 83987 CCDC8 -2.7519728 5.038789e-04 -2.1441453 2.994825e-04
117 27113 BBC3 1.5017524 3.074687e-09 1.1134730 4.976536e-06
118 23645 <NA> 0.7988109 3.681655e-04 0.5178092 3.288663e-02
119 79784 MYH14 -3.2161023 5.022167e-07 -3.3862033 9.359765e-10
120 151354 <NA> 0.9973829 3.281705e-09 0.8068247 5.502703e-08
121 6432 SRSF7 -0.5308112 1.770509e-02 -0.4885241 3.027381e-02
122 91461 <NA> -0.5131360 2.364997e-04 -0.4134268 6.372799e-05
123 25927 CNRIP1 -6.6989984 1.205616e-03 -5.2262001 2.255546e-03
124 3099 HK2 -1.7924230 3.763123e-03 -1.1143942 3.847751e-03
125 343990 CRACDL 1.5513833 9.048284e-04 1.5050862 5.244535e-06
126 164832 LONRF2 0.8062659 1.016761e-03 0.6143445 1.061975e-02
127 4175 MCM6 -1.1984461 1.248926e-02 -1.0400180 6.655388e-03
128 130574 LYPD6 -1.2606232 4.596596e-02 -1.6174273 9.289330e-03
129 114793 FMNL2 0.8390155 1.687899e-08 0.5687998 1.361514e-05
130 55854 ZC3H15 -0.6060614 1.144384e-02 -0.4326721 3.653289e-02
131 26010 SPATS2L 0.4043183 4.131201e-02 0.5234441 7.203596e-04
132 389073 C2orf80 -0.6857721 3.141838e-05 -0.3998037 4.014575e-03
133 1373 CPS1 -2.4069129 3.329915e-02 -1.5377128 1.121948e-02
134 2637 GBX2 0.9261524 4.325986e-03 0.6662947 2.507785e-02
135 10267 RAMP1 1.3725884 8.222159e-12 0.8504061 2.690388e-05
136 5834 PYGB 1.0717781 1.273346e-07 0.6080728 2.456034e-02
137 22974 TPX2 -1.3244518 9.287860e-04 -0.7959339 5.286385e-03
138 1299 COL9A3 0.5763424 4.894524e-05 0.2836497 7.718569e-03
139 3785 KCNQ2 -0.6122229 2.017555e-03 -0.6179499 3.191695e-05
140 140578 CHODL -2.8027100 5.361518e-04 -1.5336391 2.067193e-02
141 116448 <NA> 0.9341630 1.781013e-05 0.5876127 1.493659e-02
142 5121 <NA> -1.5677901 7.982074e-03 -1.1880812 4.481359e-02
143 1826 DSCAM 1.5771813 7.354962e-04 2.1020644 2.810046e-11
144 80781 COL18A1 1.3186038 2.371954e-07 0.8089897 6.655388e-03
145 1312 COMT 0.5106568 1.009903e-05 0.3231095 8.796510e-03
146 23467 <NA> 1.1217928 9.404147e-13 0.5426083 9.571565e-04
147 10752 CHL1 -1.0507620 2.039054e-12 -0.4938486 1.008946e-05
148 23171 GPD1L -1.6672836 8.686360e-04 -1.2531363 8.991416e-04
149 56992 KIF15 -1.1460509 1.350669e-02 -1.3062017 1.097283e-02
150 151887 CCDC80 0.7869097 4.245321e-08 0.5435400 4.786979e-06
151 2596 GAP43 1.6364412 2.243038e-59 1.0798978 1.176118e-32
152 11343 MGLL 0.9208202 4.827230e-05 0.6124697 8.907194e-03
153 5947 RBP1 -0.4676065 2.065758e-02 -0.7465618 2.229788e-07
154 440982 <NA> 3.0724570 3.299840e-02 3.5022415 1.313114e-03
155 10051 SMC4 -1.3310413 1.626927e-13 -0.5801032 1.293223e-03
156 8646 CHRD 1.6869291 3.299840e-02 1.7578236 2.135439e-03
157 6480 ST6GAL1 -4.2851264 1.646800e-02 -7.1414798 4.717064e-04
158 131583 FAM43A 1.7599988 8.970095e-05 1.2640133 5.295856e-03
159 347 APOD -1.9862063 1.760697e-03 -1.9388294 6.526021e-03
160 10460 TACC3 -0.9053632 1.593226e-02 -0.9375377 6.553253e-05
161 80333 KCNIP4 -2.1231152 7.429885e-05 -1.2853303 3.367812e-02
162 5099 PCDH7 -2.6026035 6.185863e-03 -1.5828258 2.013908e-02
163 5156 PDGFRA -0.9551616 3.879820e-08 -0.4385603 4.971438e-04
164 3490 IGFBP7 1.4858305 1.043598e-18 1.8278345 1.747889e-53
165 79966 SCD5 0.4050749 2.026390e-04 0.7008740 2.372241e-28
166 8404 SPARCL1 2.1765723 5.749106e-10 2.1513872 3.918759e-16
167 3015 H2AZ1 -0.7064878 1.621255e-07 -0.4993665 1.898985e-05
168 1062 CENPE -2.1755855 1.275813e-19 -0.5724353 4.658449e-03
169 55013 MCUB -0.8289339 5.110689e-03 -0.6419360 1.166422e-03
170 2983 GUCY1B1 -1.9332928 1.077333e-02 -1.3467286 1.873558e-02
171 4889 NPY5R -1.2088762 3.804174e-02 -1.3279815 1.095295e-03
172 3148 HMGB2 -1.4513006 1.140854e-07 -0.5872440 1.763412e-04
173 55714 TENM3 -2.5344066 2.026891e-13 -0.5553902 2.432824e-02
174 1767 DNAH5 5.8165242 3.636635e-02 5.6533364 4.525126e-02
175 7204 TRIO 0.7066729 8.199761e-03 0.5629365 7.524829e-03
176 6507 SLC1A3 -0.5128031 3.890674e-07 -0.3899367 5.506825e-07
177 102467080 <NA> -2.2094626 4.470417e-02 -2.7773677 4.412879e-03
178 728723 <NA> 7.3332529 9.430977e-04 6.3853331 2.150554e-02
179 22836 RHOBTB3 -0.4283172 3.417498e-02 -0.3694922 6.071604e-04
180 4001 LMNB1 -1.2366912 5.892292e-11 -0.6987209 4.365961e-06
181 2201 FBN2 -1.3303425 6.131690e-03 -1.1780917 9.492045e-03
182 10112 KIF20A -1.3658440 8.555787e-05 -1.0750296 4.376420e-04
183 84418 <NA> 0.7226909 1.854422e-03 0.4647585 2.967546e-02
184 113829 <NA> 1.2350898 5.396466e-06 0.6322482 3.538265e-02
185 57717 PCDHB16 -1.3028842 5.530593e-04 -0.7867778 1.402857e-02
186 2246 FGF1 0.7332113 8.555787e-05 0.6731462 6.551751e-05
187 202374 STK32A 1.6462918 2.485989e-03 1.2999571 6.823688e-03
188 6678 SPARC 0.7430602 6.700526e-26 0.6107188 8.261939e-23
189 9232 PTTG1 -0.6679420 1.723066e-03 -0.5335900 4.553953e-06
190 221749 PXDC1 0.5202452 1.483568e-02 0.4267824 3.943582e-02
191 51299 NRN1 2.8346049 3.048430e-04 2.7340323 1.441315e-04
192 10590 SCGN -3.2959812 5.409653e-03 -1.0164333 2.302360e-06
193 222698 NKAPL 3.5941338 1.499320e-02 3.5831756 2.563656e-04
194 7726 TRIM26 6.5704536 2.168534e-03 6.5387254 2.785842e-03
195 221491 SMIM29 0.9425016 1.718713e-04 0.4821175 4.738456e-02
196 1026 CDKN1A 1.7453810 8.686505e-79 0.8928271 5.940822e-32
197 3910 LAMA4 0.4077226 4.634758e-02 0.4381660 1.336896e-02
198 57224 NHSL1 1.4592479 5.493698e-03 1.2016807 2.723916e-02
199 6196 RPS6KA2 0.8475993 3.714411e-07 0.4745065 4.658449e-03
200 221833 SP8 -0.9898680 5.396466e-06 -0.6132468 1.683932e-03
201 55536 CDCA7L -0.7780624 2.352479e-04 -0.5031204 1.644441e-02
202 10457 GPNMB 1.5160771 1.748388e-04 1.2495676 9.793869e-04
203 4852 NPY -1.6635528 2.160922e-08 -1.3049255 1.069403e-07
204 64409 GALNT17 2.4304410 4.418133e-06 1.4306199 3.153610e-02
205 23089 PEG10 0.3634026 1.838462e-02 0.5073602 9.958056e-09
206 5054 SERPINE1 1.2476521 9.029956e-15 1.2030681 1.863591e-18
207 5764 PTN 0.3462228 1.652673e-03 0.3256584 8.725999e-07
208 8795 TNFRSF10B 0.7801657 2.767747e-02 0.8052392 2.038249e-03
209 4741 NEFM 1.8245160 2.718716e-04 1.4768708 1.675617e-03
210 4747 NEFL 1.3043536 1.356134e-07 0.8373609 5.766403e-04
211 2185 PTK2B 1.8432074 1.983800e-13 1.0401362 8.117528e-05
212 1191 CLU 0.6346144 2.842432e-18 0.3188940 5.764001e-10
213 157570 ESCO2 -2.3392823 2.150740e-02 -1.5660868 9.836713e-04
214 5327 PLAT 0.5763119 4.478844e-04 0.4540847 1.497045e-03
215 10434 LYPLA1 -1.2302889 1.589568e-03 -0.6142569 3.976121e-02
216 11075 STMN2 -4.7688923 1.772183e-02 -4.3525251 1.838981e-02
217 5375 PMP2 -1.3010953 1.823070e-46 -0.2563026 2.613947e-03
218 1345 COX6C 0.4028032 2.288205e-04 0.2365620 2.616200e-03
219 29028 ATAD2 -1.3185527 6.489143e-04 -0.8523916 1.121948e-02
220 114907 FBXO32 0.7502901 1.563154e-02 0.9131897 8.216921e-06
221 169044 <NA> 1.0208083 8.337346e-03 0.9880348 1.443547e-03
222 340371 <NA> 0.8884357 4.930026e-06 0.5513259 4.513721e-02
223 11168 PSIP1 -0.7564217 5.843104e-05 -0.3478707 1.767618e-02
224 6194 RPS6 -0.4727294 1.536550e-07 -0.1956618 2.833713e-02
225 9568 <NA> 1.8836545 4.228593e-19 1.7690687 2.524294e-26
226 10592 SMC2 -1.5498404 8.635201e-07 -0.7496846 1.262560e-02
227 2934 GSN 0.9595896 3.928363e-03 0.8539323 7.811367e-05
228 64855 NIBAN2 1.0039742 4.038707e-07 0.4461762 1.575051e-02
229 56262 LRRC8A 1.0113393 4.043294e-15 0.3689812 6.436992e-03
230 5730 PTGDS 1.3860170 1.983800e-13 0.7788765 2.690388e-05
231 4571 <NA> 0.9828721 7.409716e-07 0.8379026 2.855739e-06
232 100189191 <NA> -6.6852030 1.335824e-02 -5.7268208 3.719196e-02
233 51186 TCEAL9 0.9506406 8.102250e-13 0.3986340 5.340716e-05
234 27018 BEX3 0.2314104 1.607417e-02 0.2416858 1.629642e-04
235 1641 DCX -0.8989459 1.739980e-07 -0.7034328 1.196946e-05
236 5358 PLS3 0.6070451 1.377846e-02 0.7926681 6.018107e-08
237 10178 TENM1 -1.2341158 6.170708e-04 -1.1153249 2.026317e-05Lade nötiges Paket: gprofiler2
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 1.2991859 0.67685942 2.285445 3.321532e-01
02_TSC2_KO_Grabole_2016 1.7532671 1.34304311 2.286689 2.358088e-05
03_TSC2_Grabole-2016 1.9083166 1.44871521 2.528768 2.001931e-06
04_TSC2-tuber-Martin2017 3.9177364 1.52014793 8.493193 3.102625e-03
05_TSC2-SEN_SEGA-Martin2017 3.3787094 2.54592258 4.458609 3.086603e-16
06_all_EpilepsyGene 0.9136922 0.32971921 2.038430 1.000000e+00
07_high_conf_EpilepsyGene 0.9328263 0.11105192 3.480452 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene 2.0509392 0.54469645 5.469632 1.409101e-01
09_Epi25_dataset 0.6846692 0.01705876 3.958973 1.000000e+00
10_SFARI_all 1.4590930 0.52462921 3.272844 3.166033e-01
11_SFARI_score4plus 1.2990334 0.34713723 3.430442 5.563158e-01
12_DeRubeis_RDNV 0.7195488 0.01791718 4.166238 1.000000e+00
13_Iossifov_RDNV 1.8931988 1.05502770 3.174616 2.247509e-02
14_FMRP_Darnell 1.4892943 0.87449385 2.399380 1.134977e-01
15_Voineagu_M12 0.4945257 0.10074334 1.475620 2.930041e-01
16_Voineagu_M16 2.9424386 1.63314424 4.959172 2.803166e-04
17_ID_genes_Neel 0.8929799 0.28525539 2.136302 1.000000e+00
18_ID_genes_pinto2014 0.4781289 0.05723250 1.765901 4.470429e-01
19_Fromer_SCZ_FunDN 1.4522062 0.73400740 2.611490 2.128794e-01
20_Cocchi_Pruning 3.3992671 1.06620904 8.361197 1.971963e-02
Beta SE Padj
01_Swaminathan2018_DEPDC5KO 0.26173787 0.3326681 1.000000e+00
02_TSC2_KO_Grabole_2016 0.56148098 0.1359913 4.716177e-04
03_TSC2_Grabole-2016 0.64622152 0.1405839 4.003861e-05
04_TSC2-tuber-Martin2017 1.36551403 0.4830135 6.205249e-02
05_TSC2-SEN_SEGA-Martin2017 1.21749380 0.1443881 6.173205e-15
06_all_EpilepsyGene -0.09026153 0.5200267 1.000000e+00
07_high_conf_EpilepsyGene -0.06953629 1.0858271 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene 0.71829783 0.6764410 1.000000e+00
09_Epi25_dataset -0.37881944 1.8838123 1.000000e+00
10_SFARI_all 0.37781502 0.5218768 1.000000e+00
11_SFARI_score4plus 0.26162044 0.6732936 1.000000e+00
12_DeRubeis_RDNV -0.32913090 1.8841145 1.000000e+00
13_Iossifov_RDNV 0.63826786 0.2983168 4.495017e-01
14_FMRP_Darnell 0.39830237 0.2716390 1.000000e+00
15_Voineagu_M12 -0.70415611 0.8117465 1.000000e+00
16_Voineagu_M16 1.07923870 0.3003732 5.606332e-03
17_ID_genes_Neel -0.11319125 0.5822342 1.000000e+00
18_ID_genes_pinto2014 -0.73787502 1.0830400 1.000000e+00
19_Fromer_SCZ_FunDN 0.37308394 0.3481225 1.000000e+00
20_Cocchi_Pruning 1.22355984 0.5915563 3.943925e-01
KO effect in DIFF noRAPA
D62
getlinmodoutput(targetline = "D62",targetdiff = "DIFF",targetrapa = "noRAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 375790 AGRN -0.4095366 4.541936e-02 -0.8193766 2.940741e-03
2 51150 SDF4 -0.5045009 2.016520e-03 -0.6130317 1.126153e-04
3 64856 VWA1 -0.5711883 2.969308e-03 -1.4292346 5.573565e-15
4 1953 MEGF6 -1.0513995 1.667149e-02 -2.6636915 7.100257e-05
5 26038 CHD5 -1.2188855 8.890761e-03 -1.2908928 2.557452e-02
6 5351 PLOD1 -0.6033686 2.041058e-03 -0.5114490 3.982798e-02
7 9249 DHRS3 -1.3190383 8.751526e-16 -1.2467008 2.728191e-18
8 126917 IFFO2 -0.3809991 4.730754e-02 -1.2535537 8.070086e-09
9 2048 EPHB2 -0.8733756 2.142055e-09 -1.1159219 8.225789e-13
10 3925 STMN1 0.7854586 3.992855e-07 1.4092446 4.302212e-25
11 2537 IFI6 -0.8526948 2.873716e-06 -0.8392726 1.082687e-04
12 10657 KHDRBS1 0.4607051 7.854427e-03 0.4414765 3.164186e-02
13 65108 <NA> 0.4911297 4.223750e-02 0.9807717 2.059921e-06
14 6421 SFPQ 0.4424978 1.963220e-02 0.4953071 2.274753e-02
15 63967 CLSPN 1.5050166 2.994132e-02 1.6142082 4.662595e-02
16 84879 MFSD2A 0.9674876 1.115952e-05 1.8064180 2.239033e-20
17 6513 SLC2A1 -0.5393673 2.496997e-02 -0.7859054 2.126528e-03
18 1996 ELAVL4 3.2526117 5.784672e-06 4.0471939 5.265819e-09
19 5865 RAB3B 3.5792799 2.097445e-05 4.3609050 4.842433e-08
20 3725 JUN 0.7207107 3.071839e-08 0.5364941 6.557799e-03
21 4774 NFIA 0.5084119 9.704186e-04 0.7115189 2.442476e-05
22 91624 NEXN 0.9933624 1.064809e-03 1.2008241 4.905177e-05
23 3491 CCN1 1.1195767 8.496264e-14 1.2106373 1.267284e-12
24 9411 ARHGAP29 1.7545351 1.866874e-02 1.8531499 3.499818e-02
25 84722 PSRC1 -0.3880493 2.124082e-02 -0.5416116 5.754725e-03
26 3752 KCND3 4.4614872 1.091255e-02 4.7313571 1.538811e-02
27 7482 WNT2B -1.4641738 3.292720e-03 -3.1533870 3.473845e-02
28 54879 ST7L -1.1975888 2.855280e-03 -2.0893903 8.782753e-08
29 389 RHOC -0.7131818 4.100469e-04 -0.8086711 1.375990e-04
30 476 ATP1A1 -1.1090774 4.413887e-09 -0.6351347 7.433223e-03
31 10628 TXNIP -1.0242225 7.601973e-03 -1.5728240 8.349711e-04
32 25832 NBPF14 -0.5964256 1.125473e-02 -0.7179448 7.102298e-03
33 4170 MCL1 0.5791882 9.711034e-03 0.5315779 4.022081e-02
34 10962 MLLT11 0.6716757 4.183809e-03 0.9674580 4.717386e-04
35 6282 S100A11 -0.6710110 1.980465e-04 -1.4509000 1.147719e-08
36 112770 GLMP -1.1638935 1.575170e-04 -0.8287964 1.362657e-02
37 10485 MIR9-1HG 0.3831640 2.381681e-03 0.3859450 2.673569e-02
38 93183 PIGM -0.8618055 1.763717e-03 -0.9515013 1.694960e-03
39 477 ATP1A2 1.4300732 5.252651e-05 2.0030399 1.842601e-09
40 5999 RGS4 1.4755372 1.310525e-02 1.7994122 5.067488e-03
41 387597 ILDR2 -0.7566188 3.030088e-04 -0.9090916 1.155738e-04
42 481 ATP1B1 1.0534462 6.401206e-03 1.2793952 1.469068e-03
43 23057 NMNAT2 3.4078962 9.278183e-04 3.5039038 4.067671e-03
44 23127 COLGALT2 -0.6544929 3.489726e-03 -1.0207651 1.734016e-06
45 5997 RGS2 2.3462296 3.117778e-03 2.3989907 1.226128e-02
46 23046 KIF21B 1.3941358 4.201668e-02 2.8823435 3.849660e-10
47 23612 PHLDA3 -1.0070559 6.558898e-08 -0.5809101 1.902293e-02
48 89796 NAV1 0.9096642 9.397460e-05 1.2045189 2.779659e-08
49 55220 KLHDC8A 0.4221899 4.447089e-02 1.1680073 2.401560e-12
50 254428 SLC41A1 -0.6733399 1.170382e-02 -1.0331474 4.445111e-04
51 50486 <NA> -1.2865007 3.551702e-02 -3.7678927 6.554199e-37
52 1063 CENPF 0.9584688 1.524609e-04 0.6809078 2.438204e-02
53 3930 LBR 1.1595800 2.660623e-04 1.1648918 1.816828e-03
54 7044 LEFTY2 -1.9062784 1.973434e-02 -5.5053780 1.299284e-06
55 56776 FMN2 1.8126370 2.130849e-05 1.4381718 1.343422e-02
56 5214 PFKP -0.7177737 3.635803e-03 -0.9869597 9.825263e-04
57 1316 KLF6 0.4499054 4.566323e-02 0.9463501 3.670025e-06
58 5209 PFKFB3 0.8932132 1.722147e-06 0.6416209 7.841295e-03
59 56243 KIAA1217 -1.0182112 1.357757e-02 -1.6549404 3.325038e-04
60 57512 <NA> 6.2437538 1.069829e-02 6.1780211 4.217540e-02
61 3185 HNRNPF 0.4833284 1.223805e-02 0.5246720 4.644121e-02
62 118738 ZNF488 -1.3684277 1.512700e-05 -1.5220924 2.643263e-05
63 100507008 <NA> -1.0774683 1.550885e-02 -1.1999015 2.280369e-02
64 84159 ARID5B 1.0976502 1.040875e-09 0.7005891 1.321530e-03
65 55680 RUFY2 1.4578324 2.486895e-02 1.7756965 1.200570e-02
66 140766 ADAMTS14 -1.0682409 2.477355e-02 -1.9481264 1.072294e-04
67 64115 VSIR -1.6561828 1.474093e-04 -2.5108181 7.589827e-08
68 5660 PSAP -0.5985553 5.893906e-10 -0.6485975 8.405687e-09
69 9806 SPOCK2 -0.7097012 6.273305e-07 -0.9577646 7.542568e-10
70 5328 PLAU -0.7200618 1.829326e-02 -1.7410365 9.083042e-12
71 132 ADK 0.8363206 4.083343e-02 1.2135609 3.886456e-03
72 23522 KAT6B 0.7101744 1.234099e-02 1.1743309 1.206557e-04
73 311 ANXA11 -0.8806356 7.784308e-05 -1.0562615 5.668088e-04
74 27063 ANKRD1 -1.4270897 1.153427e-03 -2.0426851 3.030782e-04
75 9124 PDLIM1 -0.4662416 3.761093e-03 -1.8420619 1.349910e-20
76 10580 SORBS1 0.7855235 2.886969e-02 1.2166623 7.183231e-04
77 83742 MARVELD1 -1.0286767 7.174480e-03 -3.0259238 1.527708e-05
78 84171 LOXL4 -1.0912243 4.996114e-03 -2.0187601 3.426042e-05
79 25911 DPCD 1.1067700 1.338041e-03 0.9704612 3.758772e-02
80 9118 INA 2.2944904 2.357074e-09 3.0493626 2.313032e-18
81 63877 FAM204A 1.2393674 4.485084e-03 1.1310294 4.145350e-02
82 9531 BAG3 -0.6233691 2.571072e-02 -0.8178849 2.026620e-03
83 64787 EPS8L2 -1.8935110 2.340663e-02 -2.5663294 1.858836e-03
84 6181 <NA> -0.7174814 2.210442e-12 -0.4741535 3.476979e-05
85 977 CD151 -0.8681080 7.588897e-08 -0.7357631 8.423508e-04
86 54472 TOLLIP -0.4982524 3.574692e-02 -0.6498546 2.745332e-03
87 1509 CTSD -1.3935398 4.407189e-11 -1.1722509 1.071834e-11
88 975 CD81 -0.6989561 1.534773e-10 -0.5289782 1.682520e-05
89 1200 TPP1 -0.8488296 3.009729e-09 -0.6858730 2.653874e-06
90 283298 OLFML1 -2.6003629 3.508751e-04 -4.4032135 1.447613e-11
91 8495 PPFIBP2 -1.9465948 4.024658e-03 -2.6782537 2.372853e-02
92 6157 <NA> -0.4576164 1.138453e-05 -0.5739210 4.013843e-08
93 56672 AKIP1 -0.8686258 2.325365e-04 -1.0389619 1.177951e-02
94 100463486 MTRNR2L8 -0.5670028 1.677433e-05 -0.7652167 1.678545e-11
95 10335 IRAG1 2.7682411 1.357927e-03 3.4438449 2.442476e-05
96 10418 SPON1 2.3280350 3.487032e-25 2.8478625 1.018164e-36
97 100126784 <NA> -1.1031581 3.597762e-02 -2.0769832 4.911540e-04
98 90139 TSPAN18 -1.2446392 8.470947e-03 -3.2097899 1.034229e-07
99 4192 MDK -0.7494072 3.003566e-10 -1.3108852 5.259237e-23
100 54972 TMEM132A -1.5776136 1.977545e-06 -1.2161426 1.815955e-02
101 1937 <NA> -0.7085167 1.958882e-08 -0.3632931 2.369763e-02
102 6094 ROM1 -0.7308415 6.221272e-03 -0.7488741 2.219012e-02
103 51035 UBXN1 -0.6609201 4.991695e-03 -0.6196110 1.006333e-02
104 6520 SLC3A2 -0.9889574 1.618617e-12 -1.0115235 2.888269e-09
105 5920 PLAAT4 -0.8685048 5.434819e-07 -0.6796063 7.983631e-06
106 402 ARL2 -1.1010997 8.832002e-07 -0.7358065 4.016629e-03
107 4054 LTBP3 -0.9063847 9.822043e-05 -1.4519207 2.508272e-09
108 54961 SSH3 -0.9198075 9.399958e-03 -1.2848016 2.089242e-03
109 80194 TMEM134 -0.8107057 4.212660e-04 -0.8099869 2.372853e-02
110 1374 CPT1A -0.5600652 3.549433e-02 -0.8117826 7.467679e-04
111 55191 NADSYN1 -1.2628092 4.260543e-04 -1.0690123 3.470726e-02
112 6188 RPS3 -0.5220880 5.920265e-07 -0.4648421 2.598922e-05
113 2893 GRIA4 1.1706552 2.985746e-02 1.3518217 1.694079e-02
114 1410 CRYAB -0.9156951 1.652388e-06 -1.0653068 4.714061e-09
115 10525 HYOU1 -0.4883015 1.171868e-02 -0.4761770 4.158770e-02
116 403312 <NA> -3.0710157 2.124082e-02 -6.4439291 3.093675e-03
117 50937 CDON -1.2861130 1.410750e-02 -2.0978902 9.137794e-05
118 334 APLP2 -0.6864807 5.448047e-07 -0.5980690 3.633511e-08
119 84318 CCDC77 1.9559608 1.846516e-02 2.1511872 3.716361e-02
120 2597 GAPDH -0.6744001 8.190301e-11 -0.3867043 1.143118e-03
121 2 A2M 1.3474587 3.850375e-04 1.3629432 4.317881e-03
122 53919 SLCO1C1 2.1891277 4.202592e-03 3.5136960 9.991595e-10
123 51474 LIMA1 1.3616229 9.938361e-26 0.9004616 6.724941e-08
124 3164 NR4A1 1.9296629 8.141530e-03 2.9065407 2.530990e-06
125 84926 <NA> -0.9005917 1.074380e-03 -1.1135619 3.033953e-04
126 3489 <NA> -1.6158749 2.771846e-09 -2.8254651 3.159904e-19
127 967 CD63 -0.6319375 1.722591e-10 -0.3146512 4.581603e-02
128 4327 MMP19 -1.0299423 3.509051e-02 -2.3782134 1.632477e-03
129 1606 DGKA -0.8424901 7.612123e-03 -1.7099077 1.209739e-07
130 10956 OS9 -0.5445322 9.862403e-04 -0.3954939 2.732771e-02
131 4193 MDM2 -0.8867596 8.462040e-07 -0.7687663 7.925596e-06
132 10576 CCT2 0.6457436 2.425615e-05 0.4989460 2.578000e-02
133 6857 SYT1 1.6553199 6.653010e-16 1.7170863 1.103898e-11
134 1848 DUSP6 0.9381464 1.810766e-05 0.8078709 5.403907e-03
135 694 BTG1 0.8585758 2.682658e-04 1.5106789 1.368231e-10
136 7112 TMPO 1.1688164 9.282508e-03 1.2765529 1.019445e-02
137 429 <NA> -2.4723188 6.537856e-09 -1.5324763 1.191777e-03
138 51559 NT5DC3 -1.6587631 1.025955e-04 -2.5754704 4.174588e-07
139 5992 RFX4 0.8024374 3.748112e-02 1.1055461 5.672481e-03
140 9921 RNF10 -0.8939529 2.535337e-10 -0.5491389 2.306058e-03
141 100293704 <NA> 4.1563955 2.825374e-05 3.4350327 2.757241e-02
142 9612 NCOR2 -0.7602512 9.848057e-06 -0.5710013 1.021898e-03
143 100507206 LINC00943 6.2670067 1.041634e-02 7.3414130 9.659927e-04
144 219287 AMER2 2.2963669 6.465470e-03 2.5913085 3.626914e-03
145 2963 GTF2F2 -0.6050292 1.601933e-02 -0.8411555 3.360772e-03
146 1948 EFNB2 0.7101395 1.071572e-04 0.9160726 4.874069e-05
147 1284 COL4A2 -0.8486497 1.003297e-08 -0.8581541 8.485687e-09
148 4323 MMP14 -1.5278728 3.183308e-05 -0.9471221 2.920741e-02
149 26020 LRP10 -0.7125061 1.212563e-05 -0.5718418 9.659966e-04
150 5720 PSME1 -0.5474208 1.436507e-03 -0.5961568 2.539067e-03
151 9472 <NA> 1.7299691 7.413449e-03 1.8351442 4.383108e-02
152 64067 NPAS3 -0.4257191 2.027830e-02 -0.5270289 8.920812e-03
153 6235 RPS29 -0.7419613 1.250840e-11 -0.3988568 3.375981e-03
154 54331 GNG2 1.7369460 1.854177e-06 2.3657889 2.163594e-12
155 10979 FERMT2 0.4448354 1.174916e-02 0.6132385 5.687382e-04
156 652 BMP4 3.4239509 2.447949e-02 3.9282995 1.794477e-02
157 1033 CDKN3 1.4117871 1.754875e-02 1.5761865 2.062667e-02
158 5015 OTX2 -3.8567439 1.522762e-04 -8.7825497 4.552874e-08
159 23002 DAAM1 0.5663210 1.303210e-02 0.6304340 1.524497e-02
160 6252 RTN1 1.2046072 1.295980e-10 2.0068226 1.885586e-24
161 57570 TRMT5 0.5383095 1.996713e-02 0.7275723 1.994641e-03
162 3306 HSPA2 1.0034327 1.000618e-02 1.4517179 5.152929e-04
163 87 ACTN1 -0.5041066 2.248568e-05 -0.6336172 6.001777e-06
164 10577 NPC2 -0.5348598 2.832452e-03 -0.6278263 2.755529e-04
165 83694 RPS6KL1 3.8201660 2.367539e-02 4.3708508 7.955020e-03
166 7043 TGFB3 -1.7755221 6.625823e-05 -1.6010358 6.498426e-04
167 9369 NRXN3 1.2076958 2.605854e-02 2.4114552 3.790622e-08
168 145508 <NA> 7.1295244 3.778787e-04 6.8727572 3.909650e-03
169 10516 FBLN5 1.3768596 1.003297e-08 2.7433114 3.778099e-29
170 4707 NDUFB1 -0.9902840 3.074268e-17 -0.3341957 3.882418e-02
171 90050 FAM181A 0.6619662 1.475180e-02 0.8686714 1.425327e-03
172 83982 <NA> -0.7202890 1.524609e-04 -0.8509876 5.152929e-04
173 283596 SNHG10 -0.9927725 4.083343e-02 -1.3740020 3.135116e-02
174 64919 BCL11B 3.1371153 3.527181e-03 3.6254253 5.774574e-04
175 1778 <NA> -0.5485667 2.643472e-04 -0.6910382 7.226175e-04
176 7127 TNFAIP2 -1.2472245 1.314800e-07 -1.8952684 9.764034e-13
177 26153 <NA> 1.5367998 1.627414e-03 2.5552542 4.666134e-12
178 7057 THBS1 1.1322840 4.725397e-02 2.3120156 1.526250e-07
179 388115 CCDC9B -0.9707164 9.390954e-03 -0.9800008 3.091238e-02
180 825 CAPN3 -2.5049072 6.996708e-03 -2.7096515 9.066743e-03
181 10169 SERF2 -0.5095081 4.008222e-04 -0.4437709 1.077343e-02
182 2628 GATM 1.0041797 1.277399e-04 2.1362447 7.146462e-22
183 9768 PCLAF 1.0548874 4.023695e-02 1.4751358 8.189029e-04
184 6176 RPLP1 -0.6184124 1.489460e-07 -0.4588419 2.538493e-05
185 5315 PKM -0.9462179 1.335801e-13 -1.1946909 1.515324e-20
186 3073 HEXA -0.6745240 4.093446e-04 -0.9780560 4.440033e-06
187 80381 CD276 -1.2080251 9.710680e-12 -0.7212907 4.517706e-04
188 4016 <NA> -1.1621947 9.591498e-12 -2.2308563 1.475835e-19
189 57611 ISLR2 -1.5610380 9.397460e-05 -1.5080340 9.766076e-04
190 1512 CTSH -0.9583259 6.302709e-03 -2.5144022 6.510032e-08
191 64782 AEN -0.7125988 1.841671e-02 -0.6638910 4.525681e-02
192 9055 PRC1 0.8420240 1.445306e-02 1.1261837 5.275301e-04
193 6627 <NA> 0.9282727 1.628912e-02 0.9524635 1.785120e-02
194 146330 <NA> 1.2518787 7.372125e-03 1.1795037 3.470726e-02
195 1186 CLCN7 -0.9913242 1.581963e-04 -0.9764001 1.804932e-03
196 100507303 <NA> -1.6805316 4.220443e-15 -0.5121858 4.520012e-02
197 9235 IL32 -0.6818497 1.842470e-02 -1.5879467 1.420426e-07
198 84662 GLIS2 -0.8247250 2.320839e-03 -0.7922237 2.174280e-02
199 2903 GRIN2A 2.2027307 1.186896e-03 2.3038080 3.160988e-03
200 8303 SNN 0.4455792 4.644851e-02 0.5221263 4.096260e-02
201 51704 GPRC5B -0.4680241 1.239776e-02 -0.5989051 3.145272e-03
202 388228 <NA> 0.6882155 3.388523e-02 1.3196507 1.756807e-05
203 25970 SH2B1 -0.5829693 2.921922e-02 -0.6386420 4.342193e-02
204 4502 <NA> -0.8684887 2.126854e-13 -0.7408360 1.655015e-07
205 6236 RRAD -1.2954374 5.170409e-08 -1.6201892 2.264646e-10
206 8824 CES2 -0.6597458 2.165132e-04 -0.6495872 2.871545e-03
207 5699 <NA> -0.9433930 1.457500e-03 -0.9026673 1.290766e-02
208 6560 SLC12A4 -1.2108080 1.003837e-04 -1.1917565 2.167243e-05
209 999 CDH1 -2.6912992 3.675478e-03 -2.7009634 9.781015e-03
210 794 CALB2 1.4563435 2.088537e-14 2.7326036 4.233752e-48
211 497190 CLEC18B -1.7466351 1.406097e-05 -2.3578587 1.134816e-09
212 57687 <NA> 1.0462980 5.389711e-10 1.3416085 9.018065e-15
213 55839 CENPN 1.9090533 4.758100e-04 1.8937478 3.155924e-03
214 80790 CMIP 0.6259151 1.220729e-02 1.0032746 8.047882e-05
215 23199 GSE1 0.6500420 3.495892e-03 0.8982309 9.960357e-04
216 8140 SLC7A5 -1.0824671 7.858961e-22 -2.2452474 1.547199e-54
217 6137 RPL13 -0.7156228 2.316918e-06 -0.3737988 3.926732e-02
218 10381 TUBB3 0.5010398 2.416989e-03 0.9889765 1.199731e-10
219 79007 DBNDD1 -1.2128263 4.882144e-04 -1.3401715 1.812461e-04
220 11337 GABARAP -0.8348070 7.715736e-08 -0.3634791 4.902417e-02
221 5187 PER1 0.7651457 3.149675e-02 1.7124505 6.582345e-10
222 4628 MYH10 0.4612805 1.372416e-02 0.4664788 4.737911e-02
223 9423 NTN1 -0.8132813 1.369377e-05 -0.5323178 1.166804e-02
224 5376 PMP22 0.5824850 4.264601e-03 0.5750672 1.361909e-02
225 201161 <NA> 1.2126377 2.236816e-07 2.0594058 2.654752e-23
226 51655 RASD1 0.9198690 3.515780e-03 1.5883485 1.716524e-08
227 146691 TOM1L2 -0.6079747 6.706658e-04 -0.6006084 3.145272e-03
228 8851 CDK5R1 0.7194148 3.138099e-02 1.4191421 2.630099e-07
229 124842 TMEM132E -1.1219998 4.794497e-05 -0.9900478 3.356139e-03
230 7153 TOP2A 0.6511570 1.137433e-02 1.1935666 2.066820e-08
231 60681 FKBP10 -0.4783603 9.282508e-03 -0.8373423 9.942255e-06
232 4669 NAGLU -1.1848892 2.049626e-05 -0.7648877 2.447416e-02
233 10493 VAT1 -0.4830937 1.805737e-02 -0.6498699 1.231201e-03
234 8153 RND2 -0.9388098 7.327209e-04 -0.7153644 3.690794e-02
235 10900 RUNDC3A 3.4232521 1.037063e-03 4.2168733 2.487972e-06
236 51629 SLC25A39 -0.7710945 5.536538e-04 -0.6620026 1.644075e-02
237 2896 GRN -0.8731183 6.200187e-10 -1.0363383 3.516910e-10
238 23131 GPATCH8 0.9859784 8.951123e-03 1.0218764 2.447416e-02
239 2535 FZD2 -0.8609953 5.812486e-03 -0.7855913 2.362308e-02
240 2670 GFAP -0.8880523 2.924309e-14 -0.6316674 1.689940e-12
241 4836 <NA> -1.1723199 1.030154e-14 -0.6540254 3.325038e-04
242 113026 PLCD3 -0.6555781 9.747615e-04 -1.0411326 1.978628e-07
243 4804 NGFR -1.9056027 1.518377e-04 -2.0854285 5.774088e-05
244 9902 MRC2 -0.4766944 2.269338e-04 -0.8065596 5.349633e-08
245 2232 FDXR -1.1088438 2.249946e-04 -0.9142345 7.479277e-03
246 3021 H3-3B 0.4388141 1.639482e-02 0.5520628 2.606542e-03
247 91107 TRIM47 -0.5611067 3.970094e-02 -1.1071090 2.279490e-04
248 6427 SRSF2 0.6480996 1.038843e-03 0.7560787 1.133735e-03
249 57690 TNRC6C 0.9229884 2.032680e-03 1.2408552 4.864067e-05
250 7077 TIMP2 -0.5543884 1.204285e-05 -0.5314700 3.524744e-03
251 3959 LGALS3BP -1.0898674 5.878910e-11 -1.0120031 6.988221e-10
252 2548 GAA -1.1102211 2.941173e-04 -1.1230197 1.954423e-03
253 57674 RNF213 -0.8381919 1.004688e-03 -0.8197228 9.066743e-03
254 284184 NDUFAF8 -0.7896434 2.779541e-07 -0.4036235 1.838629e-02
255 124565 SLC38A10 -0.9287498 1.547999e-06 -0.7670923 8.223759e-03
256 5034 P4HB -0.4904015 4.422442e-04 -0.4531657 1.332349e-02
257 23136 EPB41L3 0.7952735 1.970178e-02 1.2231705 5.820257e-05
258 361 AQP4 1.9744058 1.884676e-21 2.4605834 5.192154e-20
259 8715 NOL4 2.5588222 5.457858e-05 2.3582394 4.119081e-03
260 56853 CELF4 2.8209731 1.393291e-02 3.6577947 1.803873e-04
261 5596 MAPK4 2.1524133 1.618136e-05 3.1760688 8.647871e-15
262 51320 MEX3C 0.7125434 1.606521e-03 0.7097423 1.580893e-02
263 6925 TCF4 0.5133689 9.417442e-03 0.6808140 3.298958e-03
264 51046 ST8SIA3 1.7149492 5.575706e-03 2.0068729 1.401190e-03
265 115701 ALPK2 -0.3734904 1.009453e-02 -0.9164225 3.602790e-06
266 90701 SEC11C 0.6300709 1.026419e-02 0.6954960 1.566203e-02
267 22850 ADNP2 0.9290115 3.211088e-02 1.0547023 3.869495e-02
268 10272 <NA> -1.9231970 1.242140e-08 -2.4261528 9.126936e-09
269 2879 GPX4 -0.8032023 9.131109e-05 -0.5574165 7.786075e-03
270 60680 CELF5 1.6306300 1.111506e-04 2.8128217 2.643450e-18
271 10362 HMG20B -0.5795260 2.201606e-02 -0.6495918 3.781472e-02
272 1938 EEF2 -0.7481511 8.743561e-11 -0.6570017 1.299284e-06
273 80700 UBXN6 -1.3411933 3.086274e-07 -0.5621434 3.470726e-02
274 25873 RPL36 -1.1973264 1.077139e-23 -0.4972307 9.698640e-04
275 126328 NDUFA11 -0.8775321 1.958882e-08 -0.4355587 4.136950e-02
276 3383 ICAM1 -0.5475674 3.043923e-02 -0.9747244 6.115328e-03
277 7297 TYK2 -0.8441545 3.482509e-03 -0.8571501 8.414839e-03
278 1995 ELAVL3 1.5915190 4.203001e-14 2.9384178 2.628971e-63
279 51398 WDR83OS -0.6712717 4.639231e-06 -0.5014992 7.895365e-03
280 4784 NFIX -0.5865548 1.171868e-02 -0.6984317 7.419264e-03
281 9592 <NA> 0.7818117 1.312546e-03 0.8378179 1.025390e-02
282 23025 UNC13A 1.9715346 3.989972e-02 2.9582727 5.511003e-04
283 54858 PGPEP1 -1.1903414 3.073928e-11 -1.2047971 6.065331e-09
284 1463 NCAN 0.5372292 5.508163e-04 1.3587582 3.010784e-20
285 57616 TSHZ3 2.1966430 1.003716e-03 2.7114870 2.719685e-05
286 1054 CEBPG 2.4854524 7.843094e-11 1.8922275 3.095694e-04
287 9710 GARRE1 -0.6555832 1.456301e-02 -0.8321661 5.924183e-03
288 7392 USF2 -0.9962607 3.825282e-06 -0.5331062 3.804954e-02
289 826 CAPNS1 -0.9240183 7.655060e-10 -0.6648593 1.818685e-04
290 7538 ZFP36 2.0965628 8.061713e-05 2.1072748 1.377638e-03
291 645 BLVRB -1.0425590 1.061855e-03 -1.1143163 3.961323e-04
292 602 BCL3 -0.6415942 1.445306e-02 -1.5072211 5.265819e-09
293 27113 BBC3 -1.3396761 1.444217e-14 -1.1519733 1.140833e-09
294 8605 PLA2G4C -1.3646974 3.798788e-02 -1.6907504 4.257213e-02
295 10945 KDELR1 -0.3259247 3.425822e-02 -0.5403373 4.295628e-03
296 6141 RPL18 -0.4015145 9.783400e-04 -0.3351432 1.357813e-02
297 51171 HSD17B14 -2.4475629 7.587371e-06 -3.0654508 8.323988e-07
298 4924 NUCB1 -0.8898897 4.396609e-08 -0.5295417 6.115328e-03
299 581 BAX -1.5018632 1.472426e-13 -0.7553891 7.965274e-06
300 2512 FTL -0.5033572 2.071844e-03 -0.6857683 6.851876e-09
301 2217 FCGRT -0.8874348 6.210984e-04 -1.0540916 1.737421e-03
302 6237 RRAS -1.0583985 1.814848e-05 -1.7603488 2.465258e-06
303 2109 ETFB -0.9172335 8.043166e-06 -0.5426740 2.598169e-02
304 147807 <NA> -1.7047506 3.039626e-02 -1.7491326 4.941566e-02
305 101060391 <NA> 2.4715761 1.427430e-02 3.7036718 2.621680e-06
306 6664 SOX11 0.6311761 3.548487e-05 1.8473670 4.632773e-31
307 57498 KIDINS220 0.6079342 4.524642e-03 0.6657516 7.176441e-03
308 6382 SDC1 -1.3382067 3.794705e-03 -1.7751396 2.960107e-03
309 5500 PPP1CB -0.3566350 1.764587e-02 -1.0157787 1.401469e-10
310 6432 SRSF7 0.9134427 4.093446e-04 0.8839854 2.387854e-03
311 9378 NRXN1 3.2466511 1.225951e-04 4.3584971 4.110696e-10
312 55704 CCDC88A 1.3788688 2.389737e-20 1.1202549 2.653548e-08
313 51255 RNF181 -0.6098092 1.128883e-03 -0.7259563 8.727483e-04
314 51652 CHMP3 -1.0700679 1.737304e-05 -0.9002936 1.351186e-03
315 400986 ANKRD36C 1.0433345 1.065900e-03 0.9147547 2.388319e-02
316 57730 ANKRD36B 0.9923870 2.687596e-04 0.8825329 2.092788e-02
317 9486 CHST10 -0.9085586 1.473834e-07 -0.9388194 3.342742e-08
318 84417 ECRG4 1.0156780 2.552547e-03 1.1657628 1.055937e-03
319 3625 <NA> -1.1562493 1.364735e-05 -1.6228571 1.002300e-04
320 2863 <NA> -1.6579966 2.066066e-03 -2.2619382 1.890523e-04
321 4249 MGAT5 0.7354107 1.063177e-02 0.9656419 1.185644e-03
322 3800 KIF5C 0.4556294 1.763758e-02 0.7199533 4.277784e-04
323 114793 FMNL2 -0.7987794 1.171565e-05 -0.8717975 2.719685e-05
324 56475 RPRM 2.6393333 2.692385e-02 3.7420358 3.679967e-04
325 90 ACVR1 1.2420487 1.899938e-02 1.5871805 3.023614e-03
326 220988 HNRNPA3 0.6389881 5.964460e-04 0.6473359 2.815547e-03
327 91404 SESTD1 1.6600210 1.111506e-04 1.5351811 9.066743e-03
328 51602 NOP58 1.2025070 2.864822e-06 1.0514439 1.143118e-03
329 8828 NRP2 -0.5317226 2.425229e-03 -0.9764990 4.361339e-09
330 8609 KLF7 0.9936242 1.325519e-06 0.9866636 4.517706e-04
331 2066 ERBB4 2.2396353 4.100469e-04 2.8991771 1.167719e-07
332 79582 SPAG16 0.6190746 4.700875e-03 0.7705482 1.955819e-03
333 6168 RPL37A -0.9396317 8.680184e-19 -0.3840962 4.163477e-03
334 3488 IGFBP5 -1.4896444 8.072817e-13 -2.6454977 5.652670e-27
335 5798 PTPRN 6.8726501 9.083539e-04 7.7871502 3.476979e-05
336 79586 CHPF -1.0246442 5.003934e-08 -0.5407254 4.362068e-02
337 7857 <NA> 2.6021431 7.706302e-10 3.7148838 2.193291e-25
338 5270 SERPINE2 -1.0018258 8.026516e-08 -1.4460396 4.552874e-08
339 151473 SLC16A14 6.8885107 9.039198e-04 7.1940831 1.593263e-03
340 5757 PTMA 0.7428128 1.652843e-04 0.7707692 1.442434e-04
341 3635 INPP5D -2.2678809 5.208667e-03 -2.8373930 6.669893e-04
342 2637 GBX2 -2.7097991 4.293880e-03 -6.3088695 1.342612e-04
343 2817 GPC1 -0.7105645 1.457500e-03 -0.7075240 3.028675e-03
344 83959 SLC4A11 -1.8193726 1.233695e-02 -2.3851510 4.644121e-02
345 57506 MAVS -0.9340439 4.124753e-05 -0.8765917 2.085698e-04
346 6238 RRBP1 -0.8779930 2.020395e-05 -0.9180331 2.592803e-04
347 2937 GSS -0.7534159 8.576030e-03 -1.0892960 8.111724e-04
348 4826 NNAT 3.1581106 1.194518e-16 5.3255153 1.206740e-19
349 84969 TOX2 -1.1548905 6.373651e-04 -1.3513027 9.689222e-04
350 51604 PIGT -0.5082443 3.110183e-02 -0.7031226 6.982086e-03
351 11065 UBE2C 1.3272127 3.482509e-03 1.7874888 3.257545e-04
352 5740 PTGIS -2.7710800 1.890294e-02 -7.0784709 9.728671e-05
353 100462983 MTRNR2L3 -0.9910046 3.609496e-03 -1.1828045 1.656836e-03
354 56937 PMEPA1 -0.5320660 3.022419e-03 -0.9454583 1.836351e-07
355 3911 LAMA5 -0.6144204 8.420533e-03 -1.2663307 1.409309e-08
356 6227 RPS21 -0.5685228 1.775938e-06 -0.4278776 1.600810e-03
357 79144 PPDPF -0.6761500 2.618381e-06 -0.4118019 1.890401e-02
358 4661 <NA> 5.8098946 7.668167e-03 7.5689872 1.158351e-05
359 140578 CHODL 0.8540394 2.124082e-02 1.2471015 1.943344e-03
360 10600 USP16 1.2808729 6.492063e-09 0.7838947 1.566203e-02
361 56245 C21orf62 0.8845232 6.769030e-04 0.9911059 1.890523e-04
362 1827 RCAN1 1.6077177 4.528098e-32 1.7948495 5.211876e-32
363 5211 PFKL -1.0086018 5.135812e-06 -0.8106155 1.782628e-03
364 80781 COL18A1 -0.6519162 3.489677e-03 -1.4193803 4.072636e-11
365 1291 COL6A1 -0.7424651 2.474967e-07 -0.6750073 2.264092e-05
366 1292 COL6A2 -1.3257081 8.242001e-04 -1.4716832 1.370357e-03
367 114044 MCM3AP-AS1 4.8345090 2.117025e-02 5.1403831 2.858695e-02
368 9993 DGCR2 -0.7484963 6.685442e-07 -0.4764508 1.488234e-02
369 652968 CASTOR1 -0.9054170 9.394588e-03 -1.0721755 5.891976e-03
370 6948 TCN2 -1.3809025 3.774116e-04 -1.2593961 5.521371e-03
371 8542 APOL1 -2.4446249 3.469519e-03 -2.7218890 4.159163e-04
372 4627 MYH9 -0.3778974 4.183716e-03 -0.6971789 5.066593e-05
373 29775 CARD10 -0.9491607 6.527177e-03 -1.3116225 2.320783e-02
374 27350 APOBEC3C -1.9712267 5.060477e-06 -2.6040539 1.588902e-06
375 6122 RPL3 -0.4053336 3.227527e-04 -0.4766353 2.816087e-04
376 468 ATF4 0.7251146 2.816812e-04 0.6186308 1.994641e-03
377 55964 SEPTIN3 0.6445300 1.469193e-04 0.9447643 4.142801e-08
378 112885 PHF21B 1.5458340 4.350773e-03 2.2259992 8.294663e-06
379 55007 FAM118A -1.0390227 1.014990e-02 -1.3407462 3.962503e-02
380 375323 LHFPL4 3.2914513 1.100144e-02 5.0276729 2.919134e-09
381 7508 XPC -0.7197664 7.140592e-03 -0.7392739 2.928362e-02
382 9975 NR1D2 -1.2999325 5.263202e-03 -1.1804262 2.990120e-02
383 7068 THRB 5.0064347 2.270573e-03 6.0866477 1.309467e-05
384 116135 LRRC3B 1.1465580 1.021039e-03 1.4798345 1.818685e-04
385 27303 RBMS3 -2.0755081 7.668167e-03 -1.9865338 4.317191e-02
386 91392 ZNF502 2.1324500 4.337593e-02 2.7812227 3.342794e-03
387 10675 CSPG5 0.8353689 1.601933e-02 1.5784377 1.185997e-06
388 4134 MAP4 -0.3390575 4.375203e-03 -0.2940204 3.587645e-02
389 2771 GNAI2 -0.4636031 8.569642e-05 -0.4944595 2.408297e-05
390 7869 SEMA3B -1.6564932 3.862308e-08 -1.4513602 1.745701e-04
391 440957 SMIM4 -0.5958505 5.117766e-04 -0.5449620 2.265123e-03
392 7086 TKT -0.9017131 4.610312e-12 -1.1391536 8.482534e-15
393 2317 FLNB -0.6845340 3.984342e-02 -1.1857779 2.745332e-03
394 11170 FAM107A 1.1009337 2.709190e-03 2.4321216 5.947464e-17
395 132204 SYNPR 3.1683107 7.361290e-13 3.1351647 8.666835e-12
396 9223 MAGI1 0.4886117 1.660351e-02 0.6969315 2.438204e-02
397 56650 CLDND1 1.0712947 1.990708e-04 0.8798926 3.725134e-02
398 961 CD47 0.8238312 1.930611e-05 0.8183946 1.397105e-04
399 55081 <NA> 1.0869656 3.821786e-05 0.9825755 9.306479e-03
400 29114 TAGLN3 0.8215485 3.700229e-03 1.9259335 6.780918e-15
401 79858 NEK11 1.3326372 1.996092e-02 1.4479830 3.333364e-02
402 7018 TF -3.3232865 2.405283e-35 -2.6389352 1.155659e-27
403 5806 PTX3 1.8501347 1.754627e-11 1.4100724 2.477616e-03
404 6657 SOX2 -0.5220920 5.263072e-05 -0.4677946 1.999204e-02
405 84002 B3GNT5 3.1685177 1.047117e-04 2.9678226 4.211058e-03
406 6480 ST6GAL1 5.2799963 3.583567e-02 6.4016047 2.265123e-03
407 6165 RPL35A -0.3520399 1.015559e-02 -0.3375458 4.897053e-02
408 53834 FGFRL1 -0.8610945 4.109856e-04 -1.0660824 1.138515e-04
409 10417 SPON2 -2.3182470 1.543773e-08 -4.2936110 9.946733e-14
410 285489 DOK7 -1.6848822 2.773213e-02 -3.3149758 2.597013e-03
411 4043 LRPAP1 -0.4776386 1.800286e-03 -0.6202236 2.425953e-04
412 27065 NSG1 1.4547421 1.538258e-03 2.5616306 3.941577e-12
413 57537 SORCS2 -0.7963868 4.223483e-02 -1.6908825 1.012552e-04
414 8532 CPZ -0.7817281 5.583150e-04 -1.1441708 6.434948e-06
415 79730 <NA> 3.1925786 8.091324e-03 3.7129693 1.177388e-03
416 9662 CEP135 2.3716028 3.901396e-03 2.3674758 2.085977e-02
417 57482 CRACD 1.4048826 1.534526e-03 1.3386405 3.473845e-02
418 2926 GRSF1 0.6163410 3.973976e-02 0.7575895 1.878569e-02
419 9508 ADAMTS3 1.2487115 3.219427e-02 1.8042029 5.566136e-03
420 9987 HNRNPDL 0.7576618 1.222739e-09 0.8450377 5.997885e-11
421 8404 SPARCL1 3.4421811 1.890294e-02 5.6833297 1.581164e-09
422 6164 RPL34 -0.2818415 9.384072e-03 -0.4235520 6.916522e-04
423 5188 <NA> -0.6434372 8.809308e-03 -1.0747561 3.095694e-04
424 84057 MND1 6.3595666 8.312957e-04 5.7683103 2.228943e-02
425 2982 GUCY1A1 -2.5615469 3.073185e-02 -2.4540368 3.596483e-02
426 3148 HMGB2 1.5486097 4.131207e-07 1.7903237 1.320091e-06
427 79682 CENPU 1.7489542 2.358664e-02 1.9973075 1.599367e-02
428 134121 <NA> 1.2796871 2.310883e-02 1.6368077 1.552128e-03
429 100505738 MIR4458HG -0.6829890 3.864705e-04 -0.9980030 1.665149e-07
430 6167 RPL37 -0.9213204 1.407983e-12 -0.3598677 3.596070e-02
431 3157 HMGCS1 0.8161423 1.619626e-04 1.1873172 5.061542e-09
432 5144 PDE4D 3.0150852 1.278346e-02 3.9688351 8.997510e-05
433 3796 KIF2A 0.7119465 2.298569e-02 0.9533351 1.000226e-02
434 4131 MAP1B 0.6409932 1.392403e-11 0.4285036 8.629839e-03
435 8507 ENC1 0.7105075 8.417686e-03 1.0075880 4.079814e-05
436 3156 HMGCR 1.1901546 1.788473e-06 1.0787649 2.908894e-04
437 7060 THBS4 1.6625515 3.700229e-03 1.9177103 1.879318e-03
438 1070 CETN3 -0.7720163 3.553947e-03 -0.5855236 4.941566e-02
439 7025 <NA> -0.5331827 4.331730e-03 -0.7465323 1.383557e-02
440 1946 EFNA5 1.7976054 3.221947e-03 2.3055068 1.364406e-04
441 324 APC 0.8236851 2.127409e-03 0.9432079 9.689222e-04
442 441108 <NA> -0.7490272 3.007057e-02 -1.0915868 2.447416e-02
443 23338 JADE2 -2.1536622 1.849520e-03 -1.8847536 1.607384e-02
444 9879 DDX46 0.4316611 3.755352e-02 0.6885911 3.449829e-03
445 9547 CXCL14 -1.1592910 2.264139e-15 -2.3882954 1.748834e-08
446 6695 SPOCK1 -1.4323253 2.985063e-06 -1.7771606 1.564048e-08
447 1958 EGR1 2.2574398 4.100469e-04 2.4815105 1.195813e-03
448 1839 HBEGF 0.7060774 3.219126e-02 1.2849143 2.137062e-04
449 2246 FGF1 0.6143881 3.167065e-02 1.0136959 1.629543e-03
450 11346 SYNPO -1.2061350 4.329632e-09 -1.2058775 8.530738e-06
451 10318 TNIP1 -1.1392066 3.351148e-08 -1.2069096 1.313948e-05
452 6678 SPARC -0.3085683 4.644851e-02 -0.5909387 2.442476e-05
453 345630 FBLL1 1.0156913 3.720260e-02 1.4519761 2.339917e-03
454 64901 RANBP17 7.3193637 1.025955e-04 6.1720844 4.190071e-02
455 1843 DUSP1 2.3289940 1.390953e-03 2.5480526 3.133156e-03
456 8992 ATP6V0E1 -0.3468481 3.024070e-02 -0.6275270 3.033400e-04
457 51617 <NA> 1.7956096 9.711090e-03 4.1012064 1.097758e-18
458 10814 CPLX2 1.6186017 1.043166e-03 3.4959251 7.251559e-29
459 11282 MGAT4B -0.7603028 1.195494e-05 -0.7867426 1.078348e-04
460 54898 ELOVL2 0.7891252 5.703222e-03 1.1113025 3.876063e-04
461 84062 DTNBP1 -1.1467664 2.702368e-05 -0.7257966 4.145350e-02
462 3400 <NA> 1.3146187 3.369625e-14 0.9409950 7.382052e-06
463 10590 SCGN 2.4250008 7.037777e-26 3.1688152 5.652459e-49
464 100129195 ZSCAN16-AS1 -0.9919782 2.318761e-03 -0.9874230 2.372853e-02
465 10537 UBD -1.3605891 1.568922e-04 -3.7566251 2.600006e-15
466 3105 HLA-A -0.7721547 2.367539e-02 -1.1999501 6.081451e-04
467 3106 HLA-B -0.7012609 3.856387e-04 -0.9622349 3.891084e-06
468 6892 TAPBP -1.1018289 1.253132e-09 -0.8933290 2.206121e-07
469 221491 SMIM29 -0.9218884 2.768231e-04 -0.8155327 1.821625e-02
470 6428 SRSF3 0.5815088 1.925323e-03 0.5327334 3.333364e-02
471 1026 CDKN1A -0.7445167 2.958591e-09 -1.0389839 9.994481e-13
472 221477 C6orf89 -0.4383175 3.119456e-02 -0.6176692 2.968614e-03
473 4188 MDFI -1.7036101 3.845899e-07 -1.4214050 5.451974e-03
474 6722 SRF 0.4945680 3.925916e-02 0.6543793 2.320783e-02
475 5429 POLH -0.8572630 4.996114e-03 -0.8523754 3.111382e-02
476 441151 TMEM151B 2.4714638 2.246212e-02 3.8518943 1.661677e-06
477 10492 SYNCRIP 0.6456309 1.146635e-04 0.6673359 5.668088e-04
478 10690 FUT9 1.6135560 4.496886e-02 2.0335869 1.478942e-02
479 100133941 CD24 0.7736300 4.061450e-04 1.0346292 5.668484e-06
480 2534 FYN 0.5662551 2.445531e-03 0.5032670 3.061403e-02
481 2697 GJA1 0.7769008 2.142055e-09 0.6745041 2.252541e-07
482 1490 CCN2 1.7576486 4.740599e-38 1.4848577 2.026620e-03
483 51696 <NA> 2.2213221 8.253492e-03 2.0533598 4.927610e-02
484 168090 C6orf118 6.5370887 9.912320e-06 7.1098054 7.340385e-07
485 51660 MPC1 1.3771688 1.179438e-16 0.8873961 2.265123e-03
486 392617 ELFN1 -0.7723583 1.361221e-02 -0.9297286 1.119240e-02
487 29886 SNX8 -0.8195445 1.012372e-03 -0.7999480 5.254358e-03
488 2115 ETV1 1.6879494 7.614340e-28 1.6873638 3.754955e-16
489 8701 DNAH11 6.6067617 3.610518e-03 7.3324766 1.005705e-03
490 4852 NPY 1.3065693 2.221224e-06 2.3309502 5.128796e-28
491 441204 <NA> -1.5495794 4.241548e-02 -3.8773492 1.752408e-04
492 79017 GGCT 1.2005300 5.250533e-06 0.9920255 1.564745e-02
493 64759 TNS3 -0.6747864 1.569101e-02 -1.2948669 1.039388e-05
494 7378 UPP1 -0.6847359 5.323075e-03 -0.9439945 8.024406e-04
495 64409 GALNT17 -1.0330728 5.765903e-06 -1.9242295 7.281613e-03
496 11257 <NA> -0.8846712 3.157582e-02 -1.2390700 1.280812e-02
497 5244 ABCB4 -0.8029967 1.000909e-02 -1.7639557 1.443107e-08
498 1750 DLX6 1.6876904 1.074380e-03 2.9617545 2.577095e-16
499 1749 DLX5 2.1403466 3.330027e-05 3.6286422 3.355781e-22
500 25798 <NA> -0.5697038 2.528938e-05 -0.4978698 1.195813e-03
501 245812 <NA> -0.6882340 3.677197e-02 -1.0333447 1.364081e-02
502 7205 <NA> -0.5610654 1.128883e-03 -0.4880182 1.476705e-02
503 5054 SERPINE1 2.8428159 3.704122e-19 2.6220037 4.061962e-14
504 2861 GPR37 1.9524966 2.425447e-04 2.6224191 2.354399e-09
505 9296 ATP6V1F -0.6297690 3.603297e-03 -0.5086225 2.619702e-02
506 4232 MEST 1.0997440 9.949038e-06 1.8222392 1.563627e-15
507 26958 COPG2 2.0279355 3.071839e-08 2.3778189 7.107555e-09
508 155066 ATP6V0E2 -0.9387413 4.901488e-10 -0.5342727 4.860574e-04
509 54480 CHPF2 -0.6816237 3.425822e-02 -0.8327015 2.138184e-02
510 349136 WDR86 -1.1448503 1.561161e-09 -1.1317281 1.661758e-04
511 79660 PPP1R3B 1.4515542 1.555100e-03 1.8445544 5.408729e-05
512 10395 DLC1 1.8666561 2.280812e-16 1.7153743 5.997885e-11
513 4747 NEFL -1.9499689 7.411800e-07 -2.8381102 5.437741e-10
514 1808 DPYSL2 0.7938179 4.526794e-10 0.9699894 2.989223e-14
515 1191 CLU -0.3536011 8.258154e-03 -0.6740472 2.714996e-07
516 80223 RAB11FIP1 -1.7252299 1.777853e-05 -2.8727814 3.109746e-05
517 286183 NKAIN3 -0.9095352 1.619177e-06 -1.0933370 2.559890e-05
518 8836 GGH -0.4446193 4.961455e-02 -1.4253748 3.883817e-10
519 5569 PKIA 1.2302738 4.545022e-03 1.2067039 2.921959e-02
520 11075 STMN2 5.0178692 4.039958e-03 6.1978578 3.966498e-04
521 862 RUNX1T1 2.3534165 9.067719e-06 3.3089522 1.119515e-13
522 7381 UQCRB -0.3130180 4.232915e-02 -0.3555414 1.242384e-02
523 79870 BAALC 0.5156894 2.569769e-04 0.4336691 1.656836e-03
524 4062 LY6H 2.3281384 9.327216e-04 3.5223270 2.754717e-10
525 1936 EEF1D -1.1117231 2.704108e-05 -0.6600540 9.022899e-03
526 113655 MFSD3 -1.2694565 1.886682e-04 -0.9020509 4.446365e-02
527 6132 RPL8 -0.7008929 8.295695e-13 -0.5470781 4.292663e-06
528 6595 SMARCA2 -0.5005963 2.128126e-02 -0.7168505 1.237660e-03
529 11168 PSIP1 1.0311192 7.655060e-10 0.4980641 4.166996e-02
530 92949 ADAMTSL1 -1.5747186 1.178586e-02 -2.3156612 5.553919e-03
531 10210 <NA> 0.8612838 2.257219e-02 0.8828085 4.667604e-02
532 2683 B4GALT1 -0.7110255 3.176405e-03 -1.5339468 1.558087e-05
533 7094 TLN1 -0.5595991 1.057199e-02 -0.6843306 1.552128e-03
534 389765 <NA> 5.4167190 2.133071e-02 5.9018589 1.550150e-02
535 8013 NR4A3 1.6926032 5.653334e-03 1.7210198 1.734746e-02
536 19 ABCA1 -0.3545432 4.929436e-02 -1.1633278 8.704903e-14
537 5998 RGS3 -0.4205005 4.337593e-02 -0.7371648 1.573076e-03
538 3371 TNC 1.4887713 2.568738e-02 1.9836646 2.549804e-03
539 5069 PAPPA -2.2794329 9.571169e-03 -3.7850262 2.918134e-03
540 1620 BRINP1 2.2480329 1.627583e-07 3.0111835 2.505557e-15
541 6136 RPL12 -0.3982599 3.179378e-03 -0.6014169 4.943460e-06
542 64855 NIBAN2 -0.5689618 2.714784e-02 -0.7917959 7.940203e-03
543 10044 SH2D3C 2.6863991 2.729971e-02 3.4168381 1.952613e-03
544 114789 SLC25A25 0.9565245 7.851947e-04 0.9885164 1.600810e-03
545 5524 PTPA -0.6516898 2.894609e-03 -0.8141781 6.648189e-04
546 100506119 LINC01503 -1.1269390 1.317657e-02 -1.7671980 4.880285e-04
547 1289 COL5A1 -1.2112262 3.804089e-03 -2.0207849 6.255122e-07
548 4851 NOTCH1 -0.5435727 3.013578e-02 -0.7688592 5.924183e-03
549 4558 <NA> -0.4390864 1.128883e-03 -0.3839364 9.338884e-03
550 4577 <NA> -1.3386473 7.087322e-15 -1.2498384 5.280320e-11
551 4567 <NA> -1.4240347 4.078910e-27 -0.5383313 1.321248e-03
552 4578 <NA> -0.6840371 3.484701e-02 -1.0416733 9.766076e-04
553 1654 DDX3X 1.1414177 1.042344e-06 0.8214014 6.765529e-03
554 4129 MAOB 0.9057778 1.524609e-04 1.4594028 1.659212e-12
555 57477 SHROOM4 -1.3916576 4.680550e-02 -2.0099208 2.076708e-02
556 170685 NUDT10 1.4053316 2.996299e-02 1.9828991 1.181037e-03
557 28986 MAGEH1 1.2557662 4.701573e-03 1.7791003 4.271693e-05
558 4675 NAP1L3 1.7653736 4.230242e-04 1.8870734 2.265123e-03
559 6173 <NA> -0.7106463 7.262684e-03 -0.8018508 8.672044e-03
560 11013 <NA> 1.5281486 3.468449e-05 2.7261900 1.113867e-23
561 55859 <NA> 0.3781885 1.716155e-02 0.3878479 2.939565e-02
562 51186 TCEAL9 -0.3892609 3.662576e-03 -0.3464859 1.041252e-02
563 5063 PAK3 1.4575697 3.804089e-03 1.5492220 1.059705e-02
564 1641 DCX 1.7378594 1.806928e-19 3.0735949 4.554326e-68
565 3597 IL13RA1 -0.6852056 4.146922e-02 -1.1106445 1.936129e-02
566 6170 RPL39 -0.4891487 3.418020e-05 -0.4737819 1.080627e-03
567 3897 L1CAM 0.9307928 4.521374e-02 1.3151852 4.894149e-03
568 2316 FLNA -0.6322225 4.888813e-07 -0.5283306 1.251199e-03
569 8270 LAGE3 -0.5948944 2.044780e-02 -0.8901983 2.894585e-03
570 2539 G6PD -0.5669937 4.023695e-02 -0.8645735 7.784778e-03
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 1.0226543 0.65019035 1.542262 9.158015e-01
02_TSC2_KO_Grabole_2016 1.8229487 1.53478736 2.164433 4.166022e-12
03_TSC2_Grabole-2016 1.9023263 1.59233264 2.277780 2.380051e-13
04_TSC2-tuber-Martin2017 3.6773344 1.96824099 6.424719 5.307322e-05
05_TSC2-SEN_SEGA-Martin2017 2.8805306 2.38227452 3.472770 7.223428e-26
06_all_EpilepsyGene 1.0868739 0.62157183 1.781176 6.950876e-01
07_high_conf_EpilepsyGene 1.3861102 0.54274367 2.966400 3.629156e-01
08_ASD_Epilepsy_EpilepsyGene 0.8233931 0.21973239 2.179563 1.000000e+00
09_Epi25_dataset 0.5616319 0.06672542 2.104121 5.862315e-01
10_SFARI_all 1.3179773 0.68673061 2.318193 3.269155e-01
11_SFARI_score4plus 1.3645524 0.63911573 2.590754 3.425416e-01
12_DeRubeis_RDNV 2.2289846 0.86174833 4.859288 4.805024e-02
13_Iossifov_RDNV 1.2967790 0.83783634 1.932040 2.129306e-01
14_FMRP_Darnell 1.4056939 0.99616952 1.939874 4.001085e-02
15_Voineagu_M12 1.0541549 0.57921150 1.779947 7.843163e-01
16_Voineagu_M16 3.3334839 2.31711243 4.692098 7.567759e-10
17_ID_genes_Neel 1.2092138 0.67761522 2.013593 4.780496e-01
18_ID_genes_pinto2014 1.0129237 0.47653675 1.911436 8.702785e-01
19_Fromer_SCZ_FunDN 0.8766391 0.51109705 1.414184 7.286343e-01
20_Cocchi_Pruning 3.9652851 2.00793636 7.242600 8.267264e-05
Beta SE Padj
01_Swaminathan2018_DEPDC5KO 0.02240145 0.23106712 1.000000e+00
02_TSC2_KO_Grabole_2016 0.60045533 0.08778749 8.332045e-11
03_TSC2_Grabole-2016 0.64307753 0.09075383 4.760102e-12
04_TSC2-tuber-Martin2017 1.30218813 0.31890198 1.061464e-03
05_TSC2-SEN_SEGA-Martin2017 1.05797452 0.09689735 1.444686e-24
06_all_EpilepsyGene 0.08330561 0.28510684 1.000000e+00
07_high_conf_EpilepsyGene 0.32650138 0.47837731 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene -0.19432159 0.67399146 1.000000e+00
09_Epi25_dataset -0.57690860 1.08686773 1.000000e+00
10_SFARI_all 0.27609825 0.33260788 1.000000e+00
11_SFARI_score4plus 0.31082645 0.38698785 1.000000e+00
12_DeRubeis_RDNV 0.80154614 0.48486641 9.610049e-01
13_Iossifov_RDNV 0.25988349 0.22286530 1.000000e+00
14_FMRP_Darnell 0.34053107 0.17569842 8.002171e-01
15_Voineagu_M12 0.05273943 0.30552398 1.000000e+00
16_Voineagu_M16 1.20401797 0.18555929 1.513552e-08
17_ID_genes_Neel 0.18997038 0.29548268 1.000000e+00
18_ID_genes_pinto2014 0.01284086 0.38472005 1.000000e+00
19_Fromer_SCZ_FunDN -0.13165989 0.27527342 1.000000e+00
20_Cocchi_Pruning 1.37757777 0.34717870 1.653453e-03
KO effect in noDIFF RAPA
D62
getlinmodoutput(targetline = "D62",targetdiff = "noDIFF",targetrapa = "RAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 64856 VWA1 0.8030245 1.460522e-02 0.8573359 2.379033e-02
2 3925 STMN1 -0.5621997 5.931549e-03 -0.6136263 1.933759e-02
3 9077 DIRAS3 1.9834594 3.993096e-17 1.5497197 2.141006e-07
4 64123 ADGRL4 1.8591906 7.536418e-05 1.6588420 3.756279e-03
5 6004 RGS16 1.1260514 1.116405e-06 1.0703477 2.320961e-03
6 149111 CNIH3 1.5152862 4.321969e-05 1.3591838 3.712089e-03
7 642938 INSYN2A 0.8676982 7.698076e-03 1.0093673 3.529990e-03
8 10581 IFITM2 -1.3183795 7.206153e-04 -1.5901730 1.290538e-04
9 4004 LMO1 -2.2592955 1.057398e-04 -2.2842552 1.029016e-08
10 960 CD44 1.4783297 1.242470e-07 1.3181342 5.315257e-05
11 1410 CRYAB 0.6528849 7.686252e-03 0.7095910 3.377235e-03
12 3709 ITPR2 1.4736906 7.945057e-05 1.4792115 6.769939e-04
13 84790 TUBA1C 0.8353178 1.261909e-05 0.7806232 1.222516e-02
14 160335 TMTC2 -0.9795429 8.552302e-03 -1.2761142 4.320227e-03
15 105376684 <NA> -7.3611655 7.343363e-03 -7.2311260 1.744505e-02
16 28526 <NA> 1.8017386 3.332743e-05 1.7352076 2.424211e-04
17 771 CA12 -0.8196275 2.710179e-04 -0.7915473 2.688799e-03
18 57611 ISLR2 -1.4079246 2.358940e-02 -1.3474653 4.246075e-02
19 56963 RGMA 1.1731544 1.258364e-08 1.0455090 3.529990e-03
20 2013 EMP2 -1.0859712 1.194183e-05 -0.7493947 3.566127e-02
21 643911 <NA> 2.7470949 2.482146e-02 2.9738926 4.672450e-03
22 2775 GNAO1 -1.1535874 8.715183e-06 -0.9192826 4.124693e-03
23 55273 TMEM100 6.4811644 1.942508e-06 5.8792099 9.207100e-04
24 11031 RAB31 0.4843884 1.403435e-02 0.5239510 1.724623e-02
25 361 AQP4 0.7596383 2.396159e-03 0.8238998 4.672450e-03
26 1995 ELAVL3 -0.7733073 5.793295e-03 -0.7804627 2.724563e-02
27 348 APOE 1.1037031 5.920378e-05 1.0484969 2.320961e-03
28 79784 MYH14 -3.8513216 3.308529e-07 -2.3025907 2.636260e-02
29 151354 <NA> 0.9477041 2.124582e-05 1.0035972 1.153129e-05
30 10267 RAMP1 1.2201730 9.879553e-07 1.0255545 3.256744e-04
31 1827 RCAN1 0.6685747 9.436088e-03 0.7360705 8.953265e-03
32 1826 DSCAM 1.3460266 7.989576e-03 1.7874228 6.724688e-06
33 2596 GAP43 1.3243424 2.481808e-23 0.9288546 1.029016e-08
34 5947 RBP1 -0.6398179 3.926367e-02 -0.7974155 1.173735e-02
35 440982 <NA> 7.2398808 5.793295e-03 7.5740840 2.320961e-03
36 4071 TM4SF1 1.8426096 6.993979e-07 1.4587178 3.712089e-03
37 3280 HES1 -0.7476753 8.866699e-04 -0.7054720 1.438330e-02
38 3490 IGFBP7 2.0336088 4.414861e-30 2.1344478 4.787056e-29
39 79966 SCD5 0.5729957 1.328968e-03 0.6559705 2.080349e-03
40 8404 SPARCL1 2.6761967 3.326139e-08 1.7055759 5.605707e-03
41 401207 C5orf63 0.6795351 2.813485e-02 0.8797647 1.201939e-03
42 85027 <NA> 0.9774337 2.531243e-03 0.7887911 2.483687e-02
43 1026 CDKN1A 1.0856110 8.078057e-15 0.8475918 1.023411e-06
44 4188 MDFI -0.9871920 4.692325e-02 -1.1913176 2.815769e-02
45 4852 NPY -1.9180616 9.454048e-08 -1.5715347 5.042983e-06
46 23089 PEG10 0.7155489 1.600641e-03 0.7365073 6.201484e-03
47 1749 DLX5 -2.2855033 8.297120e-05 -1.8452078 9.203312e-03
48 25798 <NA> -0.4903052 8.346773e-03 -0.5864822 4.672450e-03
49 5054 SERPINE1 1.9304914 3.332743e-05 2.1117923 1.740549e-06
50 4747 NEFL 1.2018058 1.301402e-05 1.2900633 1.519552e-05
51 2185 PTK2B 1.6732904 4.938218e-11 1.4023571 1.153129e-05
52 5327 PLAT 0.5947832 5.991585e-03 0.5803625 1.933759e-02
53 11075 STMN2 -6.0356503 7.560988e-03 -7.7099259 1.526840e-03
54 2171 FABP5 1.5497408 2.529428e-06 1.0759024 4.506761e-02
55 9568 <NA> 1.7738821 1.205907e-16 1.6094149 1.711089e-09
56 56548 CHST7 1.0834089 4.020573e-04 1.1287904 2.320961e-03
57 5358 PLS3 1.0402234 5.747932e-04 1.3025474 1.023411e-06
58 10178 TENM1 -1.3297755 1.057398e-04 -1.3748241 7.463147e-03
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 0.3897358 0.009685474 2.269351 5.195823e-01
02_TSC2_KO_Grabole_2016 2.3526365 1.356583136 4.115526 1.290207e-03
03_TSC2_Grabole-2016 2.2684120 1.269320303 4.208189 3.500225e-03
04_TSC2-tuber-Martin2017 6.8474658 1.349705926 21.614783 1.149345e-02
05_TSC2-SEN_SEGA-Martin2017 3.6778309 2.056336627 6.438719 7.633899e-06
06_all_EpilepsyGene 1.9288523 0.384230118 5.982515 2.151638e-01
07_high_conf_EpilepsyGene 1.9325519 0.047714939 11.405736 4.097788e-01
08_ASD_Epilepsy_EpilepsyGene 4.2468457 0.496082572 16.421962 8.619854e-02
09_Epi25_dataset 0.0000000 0.000000000 10.853125 1.000000e+00
10_SFARI_all 3.0654629 0.609145846 9.546760 8.239215e-02
11_SFARI_score4plus 2.7072417 0.317568274 10.389322 1.762594e-01
12_DeRubeis_RDNV 0.0000000 0.000000000 11.411849 1.000000e+00
13_Iossifov_RDNV 0.9199100 0.108435125 3.498929 1.000000e+00
14_FMRP_Darnell 1.9630980 0.686789897 4.589240 1.383517e-01
15_Voineagu_M12 0.0000000 0.000000000 2.557987 4.062768e-01
16_Voineagu_M16 4.6064570 1.605761676 10.826397 3.020582e-03
17_ID_genes_Neel 0.0000000 0.000000000 2.729480 6.482452e-01
18_ID_genes_pinto2014 0.0000000 0.000000000 3.735162 6.281407e-01
19_Fromer_SCZ_FunDN 2.0097658 0.526452459 5.482875 1.520947e-01
20_Cocchi_Pruning 2.6773201 0.065908045 15.920384 3.176479e-01
Beta SE Padj
01_Swaminathan2018_DEPDC5KO -0.94228631 1.8851233 1.000000000
02_TSC2_KO_Grabole_2016 0.85553663 0.2809018 0.025804142
03_TSC2_Grabole-2016 0.81908004 0.2962237 0.070004505
04_TSC2-tuber-Martin2017 1.92387863 0.8285673 0.229869090
05_TSC2-SEN_SEGA-Martin2017 1.30232316 0.2966312 0.000152678
06_all_EpilepsyGene 0.65692514 0.8231830 1.000000000
07_high_conf_EpilepsyGene 0.65884134 1.8884449 1.000000000
08_ASD_Epilepsy_EpilepsyGene 1.44617652 1.0955048 1.000000000
09_Epi25_dataset -Inf NaN 1.000000000
10_SFARI_all 1.12019860 0.8244368 1.000000000
11_SFARI_score4plus 0.99593029 1.0933636 1.000000000
12_DeRubeis_RDNV -Inf NaN 1.000000000
13_Iossifov_RDNV -0.08347946 1.0908795 1.000000000
14_FMRP_Darnell 0.67452385 0.5358422 1.000000000
15_Voineagu_M12 -Inf NaN 1.000000000
16_Voineagu_M16 1.52745901 0.5376841 0.060411632
17_ID_genes_Neel -Inf NaN 1.000000000
18_ID_genes_pinto2014 -Inf NaN 1.000000000
19_Fromer_SCZ_FunDN 0.69801819 0.6834757 1.000000000
20_Cocchi_Pruning 0.98481635 1.8899547 1.000000000
KO effect in DIFF RAPA
D62
getlinmodoutput(targetline = "D62",targetdiff = "DIFF",targetrapa = "RAPA") entrezgene genname log2FC_2.1 fdr_2.1 log2FC_2.2 fdr_2.2
1 2048 EPHB2 -0.5844492 1.601499e-02 -0.9155074 1.354145e-03
2 2537 IFI6 -0.7010783 8.040745e-03 -0.7815160 3.132856e-02
3 7802 DNALI1 1.1551849 7.457999e-03 1.1123245 2.753143e-02
4 656 BMP8B -4.3696453 8.803629e-05 -4.1397593 5.459052e-04
5 84879 MFSD2A 1.2281235 1.965733e-06 1.7552161 1.122712e-12
6 5865 RAB3B 1.6493707 4.465200e-03 2.4877824 6.594001e-08
7 3491 CCN1 0.9183982 7.579197e-06 0.7784458 2.753143e-02
8 2633 GBP1 1.8933713 1.501465e-03 1.7672396 3.995640e-03
9 127003 CFAP276 1.6882724 2.839987e-04 2.4595315 1.003361e-07
10 10628 TXNIP -1.1219260 2.851055e-03 -1.1836796 6.295463e-03
11 63827 BCAN -1.1464871 8.299200e-07 -0.6896098 4.022170e-02
12 3766 KCNJ10 -1.2044622 1.373679e-04 -1.1287694 2.169938e-03
13 257177 CFAP126 2.8399531 2.717907e-04 3.8109236 2.735624e-10
14 8490 RGS5 0.9430361 1.786616e-03 1.3273510 4.495792e-06
15 55220 KLHDC8A 0.6951021 4.636355e-02 1.0864127 8.650462e-04
16 50486 <NA> -2.1451872 2.585499e-18 -2.7830791 4.179116e-23
17 7044 LEFTY2 -1.1468367 1.385907e-02 -2.5118705 2.149008e-06
18 2786 GNG4 2.3436557 4.465200e-03 3.1398129 1.562584e-07
19 1959 EGR2 3.8846116 1.679040e-14 3.0315167 5.126766e-05
20 84858 <NA> 1.8062680 1.709089e-06 1.2785794 2.197425e-02
21 2674 GFRA1 -1.7276673 7.540604e-05 -1.9909032 7.225396e-05
22 5654 HTRA1 0.9265121 2.105270e-05 0.9286148 1.419288e-03
23 10418 SPON1 2.9482577 9.690519e-30 3.3331993 1.789378e-38
24 203859 ANO5 2.3880007 3.103096e-03 2.7523800 7.231881e-05
25 4038 LRP4 -0.7480393 8.990926e-03 -1.0202640 7.912549e-03
26 374393 FAM111B 3.2891956 3.036275e-02 3.5420547 1.522831e-02
27 79026 AHNAK 0.6654714 4.143655e-02 0.8048769 3.201026e-02
28 254263 CNIH2 1.8776550 1.040622e-04 2.0847320 2.685876e-06
29 2 A2M 1.5190611 3.193582e-12 1.4222515 1.439940e-06
30 79365 BHLHE41 1.2106415 6.905593e-04 1.2313105 3.995640e-03
31 6857 SYT1 1.6683728 8.962647e-06 1.8237151 2.110425e-06
32 101929005 <NA> -6.9708042 4.418423e-04 -4.6029204 9.008603e-03
33 114795 TMEM132B -2.0423423 5.591399e-15 -1.4960637 4.846059e-06
34 688 KLF5 1.6293748 1.038077e-03 1.2405652 4.163597e-02
35 1948 EFNB2 0.9649580 6.728368e-05 1.1098983 2.145665e-04
36 23002 DAAM1 0.7549476 2.716145e-02 0.8319282 2.753143e-02
37 6252 RTN1 1.7634057 2.333495e-12 1.5536847 2.770348e-04
38 89932 PAPLN -1.5738666 4.299050e-02 -1.9698221 1.607762e-02
39 10516 FBLN5 2.0017182 1.323846e-25 2.5486282 4.687237e-21
40 26153 <NA> 4.9439872 4.867672e-03 5.7558523 3.737899e-05
41 7057 THBS1 1.3670907 2.165183e-03 2.0696822 4.051997e-06
42 4756 NEO1 0.9731714 2.838263e-08 1.1440173 1.493514e-05
43 4916 NTRK3 1.5301080 4.829515e-08 1.3001181 1.848612e-04
44 2903 GRIN2A 2.6806855 3.126489e-05 2.5384700 4.359783e-04
45 729993 SHISA9 -3.8906884 6.900445e-22 -1.3772648 3.301516e-03
46 51704 GPRC5B -0.6965404 1.535995e-02 -0.7199939 4.400840e-02
47 5579 PRKCB -6.4499033 3.151642e-11 -2.7969992 1.322087e-02
48 999 CDH1 -4.5747249 3.016659e-16 -2.8895584 2.205613e-07
49 54768 HYDIN 3.1138005 3.384464e-07 3.4374344 7.224320e-10
50 794 CALB2 1.9731509 2.785777e-03 2.4708643 1.488766e-06
51 57687 <NA> 1.0676611 3.379263e-09 1.1174032 9.580576e-06
52 5187 PER1 1.6172545 2.138032e-03 1.9663057 3.759972e-06
53 201161 <NA> 1.0741222 7.146064e-03 1.3592159 2.907086e-04
54 7153 TOP2A 0.8905880 1.892264e-03 0.9745793 6.768778e-03
55 10882 <NA> -1.2476382 5.159240e-06 -1.2873491 1.702279e-03
56 113026 PLCD3 -0.7139995 2.028433e-02 -0.8342760 3.007915e-02
57 4804 NGFR -2.2035302 1.218551e-10 -2.1448207 1.880375e-06
58 2302 FOXJ1 1.2519998 4.679308e-06 1.3465537 1.186135e-03
59 11322 TMC6 -4.5309138 4.774950e-03 -4.0969189 3.201026e-02
60 361 AQP4 2.5635878 2.241622e-18 3.3473029 1.073340e-16
61 5596 MAPK4 1.9452939 5.842815e-04 2.2767959 8.837296e-08
62 51046 ST8SIA3 2.3074095 2.785777e-03 2.6047875 1.109491e-03
63 90701 SEC11C -0.6557054 3.229834e-02 -0.7760037 4.348299e-02
64 404217 <NA> 1.0654569 6.973826e-05 1.0074858 9.552659e-04
65 1995 ELAVL3 1.3858314 1.866195e-05 2.2025879 3.191590e-13
66 9518 GDF15 -0.7426862 4.629676e-02 -1.6933332 4.065644e-05
67 79784 MYH14 -2.3284457 1.838639e-02 -3.3398391 1.027542e-03
68 92749 DRC1 2.1683527 2.785777e-03 2.6726025 3.759972e-06
69 57628 DPP10 -5.2202074 3.664045e-08 -3.4139399 3.737899e-05
70 3625 <NA> -0.9767644 8.988301e-03 -1.6615968 4.344424e-06
71 2995 GYPC -2.3374886 4.877829e-06 -2.1257263 2.391014e-06
72 56475 RPRM 1.7750559 4.755493e-02 2.1695403 5.813931e-03
73 129881 CFAP210 2.3640626 1.471679e-03 2.4162686 4.995507e-03
74 1134 CHRNA1 -5.2042681 2.191095e-11 -8.5037878 4.066660e-08
75 8324 FZD7 -1.3257906 1.734580e-04 -1.0432077 2.405225e-02
76 8609 KLF7 1.0346818 1.544898e-05 0.8476982 1.161968e-02
77 3488 IGFBP5 -1.2071406 1.460991e-03 -1.2892386 3.417235e-03
78 5270 SERPINE2 -1.3844484 2.152519e-07 -1.2467958 4.212466e-04
79 92737 DNER 1.1950369 4.465200e-03 1.4052480 1.004895e-03
80 3769 KCNJ13 1.7547914 2.427283e-02 2.4387114 2.984745e-05
81 4826 NNAT 3.6877783 4.792925e-26 4.2006138 4.152309e-28
82 55959 SULF2 -1.4289876 1.064627e-02 -1.7780168 2.556965e-02
83 56245 C21orf62 1.0634763 4.472992e-05 0.8769423 2.790773e-02
84 116448 <NA> -1.1527437 5.652288e-03 -1.1581057 1.134540e-02
85 1827 RCAN1 0.7187131 2.320004e-03 0.9362363 1.732037e-04
86 3708 ITPR1 1.9492555 8.038676e-03 1.9058343 3.555590e-02
87 116135 LRRC3B 1.9151330 1.659171e-03 1.7449314 1.677395e-02
88 114884 OSBPL10 -1.9432227 4.481965e-03 -1.7342826 3.185883e-02
89 79442 LRRC2 3.4370870 2.321235e-03 3.6464221 2.340152e-04
90 64147 KIF9 1.5017571 1.147328e-04 2.1367445 5.934113e-08
91 11170 FAM107A 1.4033068 3.229834e-02 1.4541890 4.163597e-02
92 132204 SYNPR 6.8506004 1.926905e-04 6.6427886 2.311735e-04
93 1295 COL8A1 -4.5472935 6.661090e-03 -3.7402461 2.753143e-02
94 151887 CCDC80 0.7296925 1.713718e-02 0.8683484 1.526926e-03
95 7018 TF -3.7184564 1.721396e-66 -2.8373320 5.562076e-30
96 5947 RBP1 -1.0936355 5.253202e-07 -0.8037544 4.130282e-02
97 5806 PTX3 1.5664566 1.373679e-04 1.7610651 1.723679e-07
98 10417 SPON2 -2.4659561 1.262912e-02 -2.8343935 2.249885e-03
99 83888 <NA> -1.9573467 8.949057e-03 -2.3586659 2.311735e-04
100 201780 <NA> 1.0935517 7.536448e-06 1.0277894 5.530668e-03
101 23284 ADGRL3 -3.3750033 7.055351e-11 -1.7636588 1.363084e-03
102 9508 ADAMTS3 2.2329199 3.951529e-04 2.4736437 2.238692e-04
103 2920 CXCL2 8.1486161 1.339906e-04 7.8070786 2.129180e-04
104 134121 <NA> 1.9601335 1.873352e-04 2.7327902 2.311097e-10
105 8507 ENC1 0.9054972 2.172818e-02 1.0168645 2.863416e-02
106 1946 EFNA5 1.6668921 1.152721e-06 1.7049758 2.723816e-05
107 9547 CXCL14 -0.8082314 7.395235e-04 -1.5055991 1.936896e-09
108 6695 SPOCK1 -1.1952779 8.323687e-03 -2.2385261 6.594001e-08
109 1958 EGR1 2.4384032 1.075179e-34 2.5255163 1.444721e-18
110 1839 HBEGF 0.7097541 4.806870e-02 1.2133655 2.381940e-05
111 2878 GPX3 -1.3039233 4.367899e-08 -2.0968752 8.969947e-11
112 23286 WWC1 1.0146586 3.812164e-03 1.2949889 1.181825e-04
113 1843 DUSP1 1.9070214 3.084357e-02 1.9207454 2.742071e-02
114 51617 <NA> 6.1428862 3.114379e-03 6.8867674 3.737899e-05
115 10814 CPLX2 5.4609870 4.418423e-04 6.4008339 1.003361e-07
116 221749 PXDC1 0.6427621 5.651259e-03 0.8503611 7.732420e-03
117 84062 DTNBP1 -0.9345057 1.444723e-02 -1.0734617 7.721019e-03
118 3400 <NA> 1.0495736 1.369734e-04 1.0614846 3.046886e-03
119 10590 SCGN 3.4188121 6.157139e-11 4.5848750 6.141301e-26
120 7021 TFAP2B -8.8135379 1.003263e-07 -3.8657719 2.550146e-04
121 285755 PPIL6 1.9286056 1.035531e-02 2.0936062 3.182026e-03
122 1490 CCN2 0.9951832 6.973826e-05 0.7633184 2.561547e-02
123 80129 CCDC170 2.1577217 4.467859e-02 2.8156107 8.392469e-03
124 10457 GPNMB -1.5288283 8.425953e-04 -2.1689390 9.152129e-08
125 4852 NPY 3.1519799 7.989936e-05 4.2202467 1.680493e-14
126 6424 SFRP4 -0.7828072 4.392521e-04 -1.3460638 1.315271e-07
127 81628 TSC22D4 -0.6172060 1.874653e-02 -0.7801785 2.996625e-02
128 5054 SERPINE1 1.6825892 1.397417e-08 1.2560134 3.185320e-03
129 2861 GPR37 1.3652118 2.321235e-03 1.8253186 1.260450e-04
130 10395 DLC1 1.6104766 1.234236e-09 1.4218990 2.244802e-06
131 1808 DPYSL2 1.0102488 6.534125e-08 1.0613397 3.433965e-06
132 23643 LY96 -2.5960407 2.229924e-03 -1.9524795 4.587400e-02
133 11075 STMN2 4.3095979 1.701127e-02 5.8526106 8.836740e-09
134 6383 SDC2 0.8742833 2.175923e-04 0.7858399 1.707420e-02
135 6674 SPAG1 2.0758505 2.785777e-03 2.0003649 1.134540e-02
136 10655 DMRT2 -8.1117706 8.962647e-06 -5.7290427 5.822932e-04
137 1029 CDKN2A -1.0367133 1.263131e-03 -1.0483347 4.380981e-03
138 687 KLF9 1.4638994 4.727652e-09 1.6524793 5.934113e-08
139 9568 <NA> 2.3438085 4.465200e-03 2.2371217 2.897821e-03
140 54566 EPB41L4B -1.0946069 1.984354e-03 -1.1567214 4.914294e-04
141 1620 BRINP1 2.9326320 2.760538e-02 3.7284868 2.949459e-05
142 83543 AIF1L -0.9372391 1.138078e-03 -0.9069212 2.561547e-02
143 8021 NUP214 -0.8751811 3.911704e-03 -0.9871582 5.616330e-03
144 5730 PTGDS -2.0124717 4.957753e-20 -1.9036600 7.962779e-09
145 4129 MAOB 1.2821359 1.974426e-05 1.0076275 1.211226e-02
146 1641 DCX 3.7333185 9.772500e-19 5.0031534 1.764598e-51
147 1069 CETN2 0.6722015 1.072993e-02 0.9779653 9.712269e-05
OR CI95L CI95U P
01_Swaminathan2018_DEPDC5KO 1.1149987 0.43818873 2.373561 6.830809e-01
02_TSC2_KO_Grabole_2016 2.1717985 1.54739180 3.053726 4.324330e-06
03_TSC2_Grabole-2016 1.9878918 1.39658395 2.860079 6.169167e-05
04_TSC2-tuber-Martin2017 3.5223279 0.93001955 9.482590 3.131705e-02
05_TSC2-SEN_SEGA-Martin2017 3.9779291 2.79667249 5.619997 5.063714e-14
06_all_EpilepsyGene 1.2436682 0.39536608 2.997206 6.067161e-01
07_high_conf_EpilepsyGene 2.3177651 0.46595788 7.073113 1.476893e-01
08_ASD_Epilepsy_EpilepsyGene 3.3640623 0.88889184 9.045974 3.596164e-02
09_Epi25_dataset 0.0000000 0.00000000 4.174176 1.000000e+00
10_SFARI_all 3.2829854 1.37375335 6.757351 4.526248e-03
11_SFARI_score4plus 3.8752839 1.50753939 8.368227 3.236208e-03
12_DeRubeis_RDNV 0.0000000 0.00000000 4.388931 1.000000e+00
13_Iossifov_RDNV 0.9063491 0.28856711 2.179380 1.000000e+00
14_FMRP_Darnell 2.0928373 1.15583616 3.550296 9.859691e-03
15_Voineagu_M12 0.8090892 0.16407906 2.432547 1.000000e+00
16_Voineagu_M16 1.3925198 0.44240092 3.359152 4.172680e-01
17_ID_genes_Neel 0.5699163 0.06807157 2.113266 5.887929e-01
18_ID_genes_pinto2014 0.7801407 0.09304023 2.900996 1.000000e+00
19_Fromer_SCZ_FunDN 1.5643803 0.65844116 3.194222 2.554450e-01
20_Cocchi_Pruning 5.5901824 1.74345774 13.871443 2.783365e-03
Beta SE Padj
01_Swaminathan2018_DEPDC5KO 0.10885320 0.4765096 1.000000e+00
02_TSC2_KO_Grabole_2016 0.77555561 0.1729514 8.648660e-05
03_TSC2_Grabole-2016 0.68707467 0.1801252 1.233833e-03
04_TSC2-tuber-Martin2017 1.25912209 0.6794244 6.263410e-01
05_TSC2-SEN_SEGA-Martin2017 1.38076137 0.1797607 1.012743e-12
06_all_EpilepsyGene 0.21806524 0.5846982 1.000000e+00
07_high_conf_EpilepsyGene 0.84060339 0.8185018 1.000000e+00
08_ASD_Epilepsy_EpilepsyGene 1.21314925 0.6790454 7.192327e-01
09_Epi25_dataset -Inf NaN 1.000000e+00
10_SFARI_all 1.18875318 0.4444931 9.052497e-02
11_SFARI_score4plus 1.35461893 0.4817042 6.472416e-02
12_DeRubeis_RDNV -Inf NaN 1.000000e+00
13_Iossifov_RDNV -0.09833069 0.5839270 1.000000e+00
14_FMRP_Darnell 0.73852070 0.3029065 1.971938e-01
15_Voineagu_M12 -0.21184616 0.8140616 1.000000e+00
16_Voineagu_M16 0.33111490 0.5850274 1.000000e+00
17_ID_genes_Neel -0.56226582 1.0841479 1.000000e+00
18_ID_genes_pinto2014 -0.24828105 1.0849195 1.000000e+00
19_Fromer_SCZ_FunDN 0.44748979 0.4415153 1.000000e+00
20_Cocchi_Pruning 1.72101191 0.5944600 5.566729e-02
sessionInfo()R version 4.2.0 (2022-04-22 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 18363)
Matrix products: default
locale:
[1] LC_COLLATE=German_Germany.utf8 LC_CTYPE=German_Germany.utf8
[3] LC_MONETARY=German_Germany.utf8 LC_NUMERIC=C
[5] LC_TIME=German_Germany.utf8
attached base packages:
[1] stats4 stats graphics grDevices utils datasets methods
[8] base
other attached packages:
[1] gprofiler2_0.2.1 openxlsx_4.2.5
[3] limma_3.52.2 flashClust_1.01-2
[5] WGCNA_1.71 fastcluster_1.2.3
[7] dynamicTreeCut_1.63-1 knitr_1.39
[9] DESeq2_1.36.0 SummarizedExperiment_1.26.1
[11] Biobase_2.56.0 MatrixGenerics_1.8.0
[13] matrixStats_0.62.0 GenomicRanges_1.48.0
[15] GenomeInfoDb_1.32.2 IRanges_2.30.0
[17] S4Vectors_0.34.0 BiocGenerics_0.42.0
[19] pheatmap_1.0.12 RColorBrewer_1.1-3
[21] compareGroups_4.5.1 forcats_0.5.1
[23] stringr_1.4.0 dplyr_1.0.9
[25] purrr_0.3.4 readr_2.1.2
[27] tidyr_1.2.0 tibble_3.1.7
[29] ggplot2_3.3.6 tidyverse_1.3.1
[31] kableExtra_1.3.4
loaded via a namespace (and not attached):
[1] readxl_1.4.0 uuid_1.1-0 backports_1.4.1
[4] Hmisc_4.7-0 workflowr_1.7.0 systemfonts_1.0.4
[7] lazyeval_0.2.2 splines_4.2.0 BiocParallel_1.30.3
[10] digest_0.6.29 foreach_1.5.2 htmltools_0.5.2
[13] GO.db_3.15.0 fansi_1.0.3 checkmate_2.1.0
[16] magrittr_2.0.3 Rsolnp_1.16 memoise_2.0.1
[19] cluster_2.1.3 doParallel_1.0.17 tzdb_0.3.0
[22] Biostrings_2.64.0 annotate_1.74.0 modelr_0.1.8
[25] officer_0.4.3 svglite_2.1.0 jpeg_0.1-9
[28] colorspace_2.0-3 blob_1.2.3 rvest_1.0.2
[31] haven_2.5.0 xfun_0.31 crayon_1.5.1
[34] RCurl_1.98-1.6 jsonlite_1.8.0 genefilter_1.78.0
[37] impute_1.70.0 survival_3.3-1 iterators_1.0.14
[40] glue_1.6.2 gtable_0.3.0 zlibbioc_1.42.0
[43] XVector_0.36.0 webshot_0.5.3 DelayedArray_0.22.0
[46] scales_1.2.0 DBI_1.1.3 Rcpp_1.0.9
[49] htmlTable_2.4.1 viridisLite_0.4.0 xtable_1.8-4
[52] foreign_0.8-82 bit_4.0.4 preprocessCore_1.58.0
[55] Formula_1.2-4 truncnorm_1.0-8 htmlwidgets_1.5.4
[58] httr_1.4.3 ellipsis_0.3.2 mice_3.14.0
[61] farver_2.1.1 pkgconfig_2.0.3 XML_3.99-0.10
[64] deldir_1.0-6 nnet_7.3-17 sass_0.4.1
[67] dbplyr_2.2.1 locfit_1.5-9.6 utf8_1.2.2
[70] labeling_0.4.2 tidyselect_1.1.2 rlang_1.0.2
[73] later_1.3.0 AnnotationDbi_1.58.0 munsell_0.5.0
[76] cellranger_1.1.0 tools_4.2.0 cachem_1.0.6
[79] cli_3.3.0 generics_0.1.3 RSQLite_2.2.14
[82] broom_1.0.0 evaluate_0.15 fastmap_1.1.0
[85] yaml_2.3.5 bit64_4.0.5 fs_1.5.2
[88] zip_2.2.0 KEGGREST_1.36.3 xml2_1.3.3
[91] compiler_4.2.0 rstudioapi_0.13 plotly_4.10.0
[94] png_0.1-7 reprex_2.0.1 geneplotter_1.74.0
[97] bslib_0.4.0 stringi_1.7.6 HardyWeinberg_1.7.5
[100] highr_0.9 gdtools_0.2.4 lattice_0.20-45
[103] Matrix_1.4-1 vctrs_0.4.1 pillar_1.8.0
[106] lifecycle_1.0.1 jquerylib_0.1.4 data.table_1.14.2
[109] bitops_1.0-7 flextable_0.7.2 httpuv_1.6.5
[112] latticeExtra_0.6-30 R6_2.5.1 promises_1.2.0.1
[115] gridExtra_2.3 writexl_1.4.0 codetools_0.2-18
[118] assertthat_0.2.1 chron_2.3-57 rprojroot_2.0.3
[121] withr_2.5.0 GenomeInfoDbData_1.2.8 parallel_4.2.0
[124] hms_1.1.1 rpart_4.1.16 grid_4.2.0
[127] rmarkdown_2.14 git2r_0.30.1 lubridate_1.8.0
[130] base64enc_0.1-3 interp_1.1-3