Last updated: 2023-01-24

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Knit directory: Serreze-T1D_Workflow/

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    Untracked:  data/het-ici.vs.het-pbs_marker.freq_low.probs.freq.removed_sample.outliers.removed_geno.ratio_4.batches_myo.csv
    Untracked:  data/het-ici.vs.het-pbs_marker.freq_low.probs.freq.removed_sample.outliers.removed_geno.ratio_4.batches_myo_mis.csv
    Untracked:  data/het-ici.vs.het-pbs_sample.genos_marker.freq_low.geno.freq.4.batches_myo.csv
    Untracked:  data/het-ici.vs.het-pbs_sample.genos_marker.freq_low.geno.freq.4.batches_myo_mis.csv
    Untracked:  data/het-ici.vs.het-pbs_sample.genos_marker.freq_low.geno.freq.removed.csv
    Untracked:  data/het-ici.vs.het-pbs_sample.genos_marker.freq_low.geno.freq.removed_sample.outliers.4.batches_myo.csv
    Untracked:  data/het-ici.vs.het-pbs_sample.genos_marker.freq_low.geno.freq.removed_sample.outliers.4.batches_myo_mis.csv
    Untracked:  data/het-ici.vs.het-pbs_sample.genos_marker.freq_low.geno.freq.removed_sample.outliers.removed.csv
    Untracked:  data/het-ici.vs.het-pbs_sample.genos_marker.freq_low.probs.freq.4.batches_myo.csv
    Untracked:  data/het-ici.vs.het-pbs_sample.genos_marker.freq_low.probs.freq.4.batches_myo_mis.csv
    Untracked:  data/het-ici.vs.het-pbs_sample.genos_marker.freq_low.probs.freq.removed.csv
    Untracked:  data/het-ici.vs.het-pbs_sample.genos_marker.freq_low.probs.freq.removed_sample.outliers.4.batches_myo.csv
    Untracked:  data/het-ici.vs.het-pbs_sample.genos_marker.freq_low.probs.freq.removed_sample.outliers.4.batches_myo_mis.csv
    Untracked:  data/het-ici.vs.het-pbs_sample.genos_marker.freq_low.probs.freq.removed_sample.outliers.removed.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_marker.freq_low.geno.freq.removed_geno.ratio_4.batches_myo.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_marker.freq_low.geno.freq.removed_geno.ratio_4.batches_myo_mis.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_marker.freq_low.geno.freq.removed_sample.outliers.removed_geno.ratiov_4.batches_myo.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_marker.freq_low.geno.freq.removed_sample.outliers.removed_geno.ratiov_4.batches_myo_mis.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_marker.freq_low.probs.freq.removed_geno.ratio_4.batches_myo.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_marker.freq_low.probs.freq.removed_geno.ratio_4.batches_myo_mis.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_marker.freq_low.probs.freq.removed_sample.outliers.removed_geno.ratio_4.batches_myo.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_marker.freq_low.probs.freq.removed_sample.outliers.removed_geno.ratio_4.batches_myo_mis.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_sample.genos_marker.freq_low.geno.freq.4.batches_myo.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_sample.genos_marker.freq_low.geno.freq.4.batches_myo_mis.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_sample.genos_marker.freq_low.geno.freq.removed.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_sample.genos_marker.freq_low.geno.freq.removed_sample.outliers.4.batches_myo.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_sample.genos_marker.freq_low.geno.freq.removed_sample.outliers.4.batches_myo_mis.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_sample.genos_marker.freq_low.geno.freq.removed_sample.outliers.removed.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_sample.genos_marker.freq_low.probs.freq.4.batches_myo.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_sample.genos_marker.freq_low.probs.freq.4.batches_myo_mis.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_sample.genos_marker.freq_low.probs.freq.removed.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_sample.genos_marker.freq_low.probs.freq.removed_sample.outliers.4.batches_myo.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_sample.genos_marker.freq_low.probs.freq.removed_sample.outliers.4.batches_myo_mis.csv
    Untracked:  data/ici-myo-yes.vs.ici-myo-no_sample.genos_marker.freq_low.probs.freq.removed_sample.outliers.removed.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-10_peak.marker-UNC18805053_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-10_peak.marker-UNCHS029427_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-11_peak.marker-UNCHS031753_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-11_peak.marker-UNCHS031802_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-12_peak.marker-JAX00326005_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-12_peak.marker-UNC21995304_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-13_peak.marker-JAX00370189_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-13_peak.marker-UNCHS035661_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-14_peak.marker-UNC24597582_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-14_peak.marker-UNCHS039096_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-15_peak.marker-UNC25489755_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-15_peak.marker-UNCHS040614_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-16_peak.marker-UNCHS042686_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-17_peak.marker-UNCHS043777_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-17_peak.marker-UNCHS043880_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-18_peak.marker-UNC29296831_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-18_peak.marker-UNC29297751_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-19_peak.marker-UNC30069852_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-19_peak.marker-UNC30386742_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-1_peak.marker-UNCHS001121_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-1_peak.marker-UNCHS002308_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-2_peak.marker-UNC3990359_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-2_peak.marker-UNCHS006135_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-3_peak.marker-JAX00105915_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-3_peak.marker-UNC6020011_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-4_peak.marker-UNC8099452_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-4_peak.marker-UNC8161950_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-5_peak.marker-UNC9678100_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-5_peak.marker-UNC9678931_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-6_peak.marker-UNC12162881_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-6_peak.marker-backupUNC060363218_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-7_peak.marker-UNC12719038_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-7_peak.marker-UNCHS022024_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-8_peak.marker-UNC14948439_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-8_peak.marker-UNCHS023592_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-9_peak.marker-UNC16009822_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-9_peak.marker-UNC17271730_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-X_peak.marker-UNC31358512_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_blup_sub_chr-X_peak.marker-UNCHS049472_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-10_peak.marker-UNC18805053_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-10_peak.marker-UNCHS029427_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-11_peak.marker-UNCHS031753_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-11_peak.marker-UNCHS031802_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-12_peak.marker-JAX00326005_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-12_peak.marker-UNC21995304_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-13_peak.marker-JAX00370189_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-13_peak.marker-UNCHS035661_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-14_peak.marker-UNC24597582_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-14_peak.marker-UNCHS039096_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-15_peak.marker-UNC25489755_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-15_peak.marker-UNCHS040614_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-16_peak.marker-UNCHS042686_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-17_peak.marker-UNCHS043777_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-17_peak.marker-UNCHS043880_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-18_peak.marker-UNC29296831_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-18_peak.marker-UNC29297751_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-19_peak.marker-UNC30069852_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-19_peak.marker-UNC30386742_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-1_peak.marker-UNCHS001121_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-1_peak.marker-UNCHS002308_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-2_peak.marker-UNC3990359_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-2_peak.marker-UNCHS006135_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-3_peak.marker-JAX00105915_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-3_peak.marker-UNC6020011_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-4_peak.marker-UNC8099452_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-4_peak.marker-UNC8161950_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-5_peak.marker-UNC9678100_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-5_peak.marker-UNC9678931_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-6_peak.marker-UNC12162881_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-6_peak.marker-backupUNC060363218_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-7_peak.marker-UNC12719038_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-7_peak.marker-UNCHS022024_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-8_peak.marker-UNC14948439_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-8_peak.marker-UNCHS023592_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-9_peak.marker-UNC16009822_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-9_peak.marker-UNC17271730_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-X_peak.marker-UNC31358512_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_genes_chr-X_peak.marker-UNCHS049472_lod.drop-1.5_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_gm_qtl_snpsqc_dis_no-x_updated_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_marker.freq_low.geno.freq.removed_geno.ratio_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_marker.freq_low.geno.freq.removed_geno.ratio_4.batches_myo_mis.csv
    Untracked:  data/ici-sick.vs.ici-eoi_marker.freq_low.geno.freq.removed_sample.outliers.removed_geno.ratio_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_marker.freq_low.geno.freq.removed_sample.outliers.removed_geno.ratio_4.batches_myo_mis.csv
    Untracked:  data/ici-sick.vs.ici-eoi_marker.freq_low.geno.freq.removed_sample.outliers.removed_geno.ratiov_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_marker.freq_low.geno.freq.removed_sample.outliers.removed_geno.ratiov_4.batches_myo_mis.csv
    Untracked:  data/ici-sick.vs.ici-eoi_marker.freq_low.probs.freq.removed_geno.ratio_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_marker.freq_low.probs.freq.removed_geno.ratio_4.batches_myo_mis.csv
    Untracked:  data/ici-sick.vs.ici-eoi_marker.freq_low.probs.freq.removed_sample.outliers.removed_geno.ratio_4.batches_myo.csv
    Untracked:  data/ici-sick.vs.ici-eoi_marker.freq_low.probs.freq.removed_sample.outliers.removed_geno.ratio_4.batches_myo_mis.csv
    Untracked:  data/ici-sick.vs.ici-eoi_sample.genos_marker.freq_low.geno.freq.4.batches_myo_mis.csv
    Untracked:  data/ici-sick.vs.ici-eoi_sample.genos_marker.freq_low.geno.freq.removed.csv
    Untracked:  data/ici-sick.vs.ici-eoi_sample.genos_marker.freq_low.geno.freq.removed_4.batches_myo_mis.csv
    Untracked:  data/ici-sick.vs.ici-eoi_sample.genos_marker.freq_low.geno.freq.removed_sample.outliers.4.batches_myo_mis.csv
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Unstaged changes:
    Modified:   analysis/index_5.batches.Rmd

Note that any generated files, e.g. HTML, png, CSS, etc., are not included in this status report because it is ok for generated content to have uncommitted changes.


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Neogen Files At A Glance [Total Samples: 217]

Haplotype Phasing

1. Experiment Design

abbreviations for strains: AB: het; AA: hom
type of cross: Backcross
number of mice phenotyped: 217
total number of mice phenotypes: 2 [1 binary/1 quantiative]
phenotypes: myocarditis status/group [binary] & age of onset [continuous]
number of mice: 217
number of markers: 137302
covariates: sex [F: 196; M: 21] ; and others depending on samples used in analysis

2. Genotype QC

3. Phenotype QC

continous phenotypes (age of onset) [not necessary for current analysis]

4. QTL Analysis

binary phenotpe

  1. removed additional low frequency markers as well as disproportionate markers (identified in Step 2.4) within each sample set
  2. no X covariate (ie. Xcovar); using sex as a covariate
  3. no kinship included as r/qtl2 does not allow for the inclusion of a kinship matrix in this type of model
  4. For each model run, permutations (1000) were used for each model to obtain genome-wide LOD significance threshold for p < 0.01, p < 0.05, p < 0.10, respectively, separately for X and automsomes (A)

The following analysis has been done with age of onset as all samples have a value:….

continous phenotypes (age of onset)

  1. removed additional low frequency markers as well as disproportionate markers (identified in Step 2.4) within each sample set
  2. disease status was used as a binary covariate (that is, diabetes/no diabetes or yes/no) for analyses in each sample set
  3. no X covariate (ie. Xcovar) 4 no kinship included
  4. For each model run, permutations (1000) were used for each model to obtain genome-wide LOD significance threshold for p < 0.01, p < 0.05, p < 0.10, respectively, separately for X and automsomes (A)

….

5. Power Analysis

….


R version 4.2.2 (2022-10-31)
Platform: x86_64-apple-darwin17.0 (64-bit)
Running under: macOS Big Sur ... 10.16

Matrix products: default
BLAS:   /Library/Frameworks/R.framework/Versions/4.2/Resources/lib/libRblas.0.dylib
LAPACK: /Library/Frameworks/R.framework/Versions/4.2/Resources/lib/libRlapack.dylib

locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] ggrepel_0.9.2     qtlcharts_0.16    qtl2_0.30         broman_0.80      
 [5] ggplot2_3.4.0     tibble_3.1.8      readxl_1.4.1      cluster_2.1.4    
 [9] dplyr_1.0.10      optparse_1.7.3    mclust_6.0.0      tidyr_1.2.1      
[13] data.table_1.14.6 knitr_1.41        kableExtra_1.3.4  workflowr_1.7.0  

loaded via a namespace (and not attached):
 [1] Rcpp_1.0.9        svglite_2.1.0     getPass_0.2-2     ps_1.7.2         
 [5] assertthat_0.2.1  rprojroot_2.0.3   digest_0.6.30     utf8_1.2.2       
 [9] R6_2.5.1          cellranger_1.1.0  RSQLite_2.2.19    evaluate_0.18    
[13] httr_1.4.4        pillar_1.8.1      rlang_1.0.6       rstudioapi_0.14  
[17] blob_1.2.3        whisker_0.4.1     callr_3.7.3       jquerylib_0.1.4  
[21] rmarkdown_2.18    qtl_1.54          webshot_0.5.4     stringr_1.5.0    
[25] bit_4.0.5         munsell_0.5.0     compiler_4.2.2    httpuv_1.6.6     
[29] xfun_0.35         pkgconfig_2.0.3   systemfonts_1.0.4 htmltools_0.5.3  
[33] tidyselect_1.2.0  fansi_1.0.3       viridisLite_0.4.1 withr_2.5.0      
[37] later_1.3.0       grid_4.2.2        jsonlite_1.8.4    gtable_0.3.1     
[41] lifecycle_1.0.3   DBI_1.1.3         git2r_0.30.1      magrittr_2.0.3   
[45] scales_1.2.1      cli_3.4.1         stringi_1.7.8     cachem_1.0.6     
[49] fs_1.5.2          promises_1.2.0.1  getopt_1.20.3     xml2_1.3.3       
[53] bslib_0.4.1       generics_0.1.3    vctrs_0.5.1       tools_4.2.2      
[57] bit64_4.0.5       glue_1.6.2        purrr_0.3.5       parallel_4.2.2   
[61] processx_3.8.0    fastmap_1.1.0     yaml_2.3.6        colorspace_2.0-3 
[65] rvest_1.0.3       memoise_2.0.1     sass_0.4.4