2024-03-05_CheckTranslatedReads
2024-03-05
Last updated: 2024-03-07
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ChromatinSplicingQTLs/analysis/
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I have identified long reads that are full length transcripts and translated them. I took two approaches to translate them: (1) using 5’ most annotated start codon, or (2) using longest ORF. Now I can apply NMD rules to investigate the fraction of reads that are NMD targeted or not and for which reason (eg the 55nt rule, PTC close to the START codon may is not efficiently targeted for NMD due to downstream reinitioation (Lindeboom 2016))…
library(data.table)
library(tidyverse)
# Set theme
theme_set(
theme_classic() +
theme(text=element_text(size=16, family="Helvetica")))
# I use layer a lot, to rotate long x-axis labels
Rotate_x_labels <- theme(axis.text.x = element_text(angle = 45, vjust = 1, hjust=1))dat <- c(Sys.glob("../code/LongReads/bed12translated/*/CTRL*_shRNA.*.bed.gz"),
Sys.glob("../code/LongReads/bed12translated/*/GM[1234].bed.gz"),
Sys.glob("../code/LongReads/bed12translated/*/SMG6_SMG7_shRNA.SAMEA8691113.bed.gz")) %>%
setNames(str_replace(., "../code/LongReads/bed12translated/(.+?)/(.+?).bed.gz", "\\1;\\2")) %>%
lapply(fread, col.names=paste0("Col", 1:13)) %>%
bind_rows(.id="approach_sample") %>%
separate(approach_sample, into=c("ORF.translation.approach", "sample"), sep=";") %>%
mutate(SeqNoBars = str_replace_all(Col13, "|", "")) %>%
mutate(CDS=str_extract(SeqNoBars,"\\^.+?(\\*|$)")) %>%
unite(Read, Col1:Col6)Tester code to forumalte regex to match conditions in lindeboom
test_str <- "GCGGATCCCAGCGGCGGTCGTGTAGCTGAGCAGCCCTGGGGCTTGGTTCTATGTCCCTGTGG|CT^ATGTTTCCAGTGTCCTCTGGGTGTTTCCAAGAGCAACAAGAAACGAATAAATCTCTG|ACCCTTCTCAGGTGCAGCCAGAGAGACACTAGCCCACTGATGGATGGACAGACGTGGGCAGGGTCCGTGTCACTAAACCACCCACCACTGCCACAGCTGCCTACAACAGACACATCAGATGACACTCCGGGCAAATAA*ATGATTTTCA"
test_str2 <- "GCGGATCCCAGCGGCGGTCGTGTAGCTGAGCAGCCCTGGGGCTTGGTTCTATGTCCCTGTGG|CT^ATGTTTCCAGTGTCCTCTGGGTGTTTCCAAGAGCAACAAGAAACGAATAAATCTCTG|ACCCTTCTCAGGTGCAGCCAGAGAGACACTAGCCCACTGATGGATGGACAGACGTGGGCAGGGTCCGTGTCACTAAACCACCCACCACTGCCACAGCTGCCTACAACAGACACATCAGATGACACTCCGGGCAAATAAATGATTTTCA"
test_str3 <- "GCGGATCCCAGCGGCGGTCGTGTAGCTGAGCAGCCCTGGGGCTTGGTTCTATGTCCCTGTGG|CTATGTTTCCAGTGTCCTCTGGGTGTTTCCAAGAGCAACAAGAAACGAATAAATCTCTG|ACCCTTCTCAGGTGCAGCCAGAGAGACACTAGCCCACTGATGGATGGACAGACGTGGGCAGGGTCCGTGTCACTAAACCACCCACCACTGCCACAGCTGCCTACAACAGACACATCAGATGACACTCCGGGCAAATAAATGATTTTCA"
test_str4 <- "GCGGATCCCAGCGGCGGTCGTGTAGCTGAGCAGCCCTGGGGCTTGGTTCTATGTCCCTGTGG|CTATGTTTCCAGTGTCCTCTGGGTGT*TTCCAAGAGCAACAAGAAACGAATAAATCTCTG|ACCCTTCTCAGGTGCAGCCAGAGAGACACTAGCCCACTGATGGATGGACAGACGTGGGCAGGGTCCGTGTCACTAAACCACCCACCACTGCCACAGCTGCCTACAACAGACACATCAGA*TGACACTCCGGGCAAATAAATGATTTTCA"
test_str5 <- "GATC*CA|GT"
test_str6 <- "GCGGATCCCAGCGGCGGTCGTGTAGCTGAGCAGCCCTGGGGCTTGGTTCTATGTCCCTGTGG|CTATGTTTCCAGTGTCCTCTGGGTGT*TTCCAAGAGCAACAAGAAACGAATAAATCTCTGACCCTTCTCAGGTGCAGCCAGAGAGACACTAGCCCACTGATGGATGGACAGACGTGGGCAGGGTCCGTGTCACTAAACCACCCACCACTGCCACAGCTGCCTACAACAGACACATCAGTTCCAAGAGCAACAAGAAACGAATAAATCCAAGAGCAACAAGAAACGAATAAATCTCTGACCCTTCTCAGGTGCAGCCAGAGAGACACTAGCCCACTGATGGATGGACAGACGTGGGCAGGGTCCGTGTCACTAAACCACCCACCACTGCCACAGCTGCCTACAACAGACACATCAGTTCCAAGAGCAACAAGAAACGAATAAACAGGGTCCGTGTCACTAAACCACCCACCACTGCCACAGCTGCCTACAACAGACACATCAGTTCCAAGAGCAACAAGAAACGAAT|AAA"
test_str7 <- "GCGGATCCCAGCGGCGGTCGTGTAGCTGAGCAGCCCTGGGGCTTGGTTCTATGTCCCTGTGG|CTATGTTTCCAGTGTCCTCTGGGTGT*TTCCAAGAGCAACAAGAAACGAATAAATCTCTGACCCTTCTCAGGTGCAGCCAGAGAGACACTAGCCCACTGATGGATGGACAGACGTGGGCAGGGTCCGTGTCACTAAACCACCCACCACTGCCACAGCTGCCTACAACAGACACATCAGTTCCAAGAGCAACAAGAAACGAATAAATCCAAGAGCAACAAGAAACGAATAAATCTCTGACCCTTCTCAGGTGCAGCCAGAGAGACACTAGCCCACTGATGGATGGACAGACGTGGGCAGGGTCCGTGTCACTAAACCACCCACCACTGCCACAGCTGCCTACAACAGACACATCAGTTCCAAGAGCAACAAGAAACGAATAAACAGGGTCCGTGTCACTAAACCACCCACCACTGCCACAGCTGCCTACAACAGACACATCAGTTCCAAGA*GCAACAAGAAACGAAT|AAA"
str_extract(test_str3, "\\^.+?(\\*|$)")
# Is in last exon
str_detect(test_str5, "(^|\\|)[ACGTacgt]*+\\*[ACGTacgt]*+$")
# Get length of exon
str_length(str_extract(test_str6, "(^|\\|)[ACGTacgt]*+\\*[ACGTacgt]*+\\|"))
str_detect(test_str7, "\\*[ACGTNacgtn]{0,50}\\|[ACGTNacgtn]*+$")Check read counts and read lengths by sample… Keep in mind these are already filtered for “full length” reads meaning anchored at annotated TSS and TES.
dat %>%
mutate(ReadLen = str_length(SeqNoBars)) %>%
ggplot(aes(x=ReadLen, color=sample)) +
stat_ecdf() +
scale_x_continuous(trans='log10') +
labs(x="ReadLen", y="ecdf")
dat %>%
count(sample) %>%
ggplot(aes(x=sample, y=n)) +
geom_col() +
Rotate_x_labels +
labs(y="ReadCount")
Check ORF length
dat %>%
filter(sample=="GM3") ORF.translation.approach sample
1: firstORF GM3
2: firstORF GM3
3: firstORF GM3
4: firstORF GM3
5: firstORF GM3
---
106428: longestORF GM3
106429: longestORF GM3
106430: longestORF GM3
106431: longestORF GM3
106432: longestORF GM3
Read Col7
1: chr1_944204_959256_m54304_190613_163530/6554329/ccs_60_- 948558
2: chr1_944206_959256_m54304_190614_125656/51970423/ccs_60_- 946412
3: chr1_944210_959256_m54304_190611_190806/16974716/ccs_60_- 944691
4: chr1_944213_959256_m54304_190614_125656/47055487/ccs_60_- 944691
5: chr1_944214_959265_m54304_190611_190806/15532359/ccs_60_- 945336
---
106428: chrY_19705414_19744723_m54304_190611_190806/21299539/ccs_60_- 19710174
106429: chrY_19705420_19744726_m54304_190614_125656/69337524/ccs_60_- 19705992
106430: chrY_20575800_20592630_m54304_190615_091702/27788010/ccs_60_+ 20575871
106431: chrY_57067864_57130286_m54304_190613_163530/50463368/ccs_0_+ 57075986
106432: chrY_57067864_57130286_m54304_190613_163530/67568216/ccs_0_+ 57084730
Col8 Col9 Col10
1: 959240 0 12
2: 959240 0 18
3: 959240 0 19
4: 959240 0 19
5: 959240 0 18
---
106428: 19744534 0 27
106429: 19716389 0 26
106430: 20592348 0 6
106431: 57128661 0 7
106432: 57128473 0 8
Col11
1: 942,136,114,144,102,114,91,121,132,175,153,42
2: 940,136,114,144,102,114,112,140,124,114,111,79,91,121,132,175,153,42
3: 590,90,136,114,144,102,114,112,140,189,114,111,79,91,121,132,175,153,42
4: 587,90,136,114,144,102,105,112,140,189,114,111,79,91,121,132,175,153,42
5: 586,612,114,144,102,114,112,140,189,114,111,79,91,121,132,175,153,51
---
106428: 931,168,70,600,138,180,139,810,97,148,125,182,195,120,163,182,159,120,159,146,130,135,171,123,78,169,53
106429: 925,200,70,600,138,180,139,359,97,148,125,182,437,163,182,159,120,159,146,130,135,171,123,78,169,56
106430: 87,84,104,82,92,290
106431: 104,155,58,138,91,93,1884
106432: 104,155,62,138,91,68,93,1884
Col12
1: 0,1313,1968,2197,3926,4285,11718,11890,12689,12894,14724,15010
2: 0,1311,1966,2195,3924,4283,6920,7793,8205,8968,9575,9797,11716,11888,12687,12892,14722,15008
3: 0,846,1307,1962,2191,3920,4279,6916,7789,8201,8964,9571,9793,11712,11884,12683,12888,14718,15004
4: 0,843,1304,1959,2188,3917,4276,6913,7786,8198,8961,9568,9790,11709,11881,12680,12885,14715,15001
5: 0,827,1958,2187,3916,4275,6912,7785,8197,8960,9567,9789,11708,11880,12679,12884,14714,15000
---
106428: 0,1026,1379,1732,2519,2829,3460,4036,4961,9937,10200,10408,10864,11181,15457,15715,26357,26631,27169,29937,30206,34113,35903,36320,37747,38970,39256
106429: 0,1020,1373,1726,2513,2823,3454,4030,4955,9931,10194,10402,10858,15451,15709,26351,26625,27163,29931,30200,34107,35897,36314,37741,38964,39250
106430: 0,3807,6789,12223,13683,16540
106431: 0,8113,14278,16767,19152,58356,60538
106432: 0,8113,14278,16767,19152,38468,58356,60538
Col13
1: GCTTCGGGTTGGTGTC^ATGGCAGCTGCGGGGAGCCGCAAGAG|GCGCCTGGCGGAGCTGACGGTGGACGAGTTCCTAGCTTCGGGCTTTGACTCCGAGTCCGAATCCGAGTCCGAAAATTCTCCACAAGCGGAGACACGGGAAGCACGCGAGGCTGCCCGGAGTCCGGATAAGCCGGGCGGGAGCCCCTCGGCCAG|CCGGCGTAAAGGCCGTGCCTCTGAGCACAAAGACCAGCTCTCTCGGCTGAAGGACAGAGACCCCGAGTTCTACAAGTTCCTGCAGGAGAATGACCAGAGCCTGCTAAACTTCAGCGACTCGGACAGCTCTGAGGAGGAAGAGGGGCCGTTCCACTCCCTGCCAGATGTGCTGGAG|GAAGCCAGTGAGGAGGAGGATGGAGCGGAGGAAGGAGAAGATGGGGACAGAGTCCCCAGAGGGCTGAAGGGGAAGAAGAATTCTGTTCCTGTGACCGTCGCCATGGTTGAGAGATGGAAGCAGGCAGCAAAG|CAACGCCTCACTCCAAAGCTGTTCCATGAAGTGGTACAGGCGTTCCGAGCAGCTGTGGCCACCACCCGAGGGGACCAGGAAAGTGCTGAGGCCAACAAATTCCAGGTCACGGACAGTGCTG|CATTCAATGCTCTGGTTACCTTCTGCATCAGAGACCTCATTGGCTGTCTCCAGAAGCTGCTGTTTGGAAAGGTGGCAAAGGATAGCAGCAG|ATGTTCCAGCAGGTCGACTTCAACAGGAAGCCAGGGCGCATGA*GCTCCAAGCCCATCAACTTCTCCGTGATCCTGAAGCTGTCCAATGTCAACCTGCAGGAGAAGGCGTACCGG|GACGGCCTGGTGGAGCAGCTGTACGACCTCACCCTGGAGTACCTGCACAGCCAGGCACACTGCATCGGCTTCCCGGAGCTGGTGCTGCCTGTGGTCCTGCAG|CTGAAGTCGTTCCTCCGGGAGTGCAAGGTGGCCAACTACTGCCGGCAGGTGCAGCAGCTGCTTGGGAAGGTTCAGGAGAACTCGGCATACATCTGCAGCCGCCGCCAGAGGGTTTCCTTCGGCGTCTCTGAGCAGCAGGCAGTG|GAAGCCTGGGAGAAGCTGACCCGGGAAGAGGGGACACCCCTGACCTTGTACTACAGCCACTGGCGCAAGCTGCGTGACCGGGAGATCCAGCTGGAGATCAGTGGCAAAGAGCGG|CTGGAAGACCTGAACTTCCCTGAGATCAAACGAAGGAAGATGGCTGACAGGAAGGATGAGGACAGGAAGCAATTTAAAGACCTCTTTGACCTGAACAGCTCTGAAGAGGACGACACCGAGGGATTCTCGGAGAGAG|GGATACTGAGGCCCCTGAGCACTCGGCATGGGGTGGAAGACGATGAAGAGGACGAGGAGGAGGGCGAGGAGGACAGCAGCAACTCGGAGGGTGAATGGTCTTGGGGTGAGAGGGTGTGGCCCTGTGAGCCCATCTGGCGGGAGGGCAGAGCCACGTGGGCGGGGGGCGTGGGGCTCTGGGCCAGGCTTTTCCCTCCCTGGGAAGGCCAGGCCAAATGCTCTGTTCTCTGGCAGCCAGCAACAGGGATAAATTAATTAGTGCCGTGATTAATTAGTGATGAGTAACCTCTAAGGCTGGCTTCTTCCTGATAAAGCAAAATTTATGTAGCCTCCATCTCTCCCCGCAGATGGAGACCCAGACGCAGAGGCGGGGCTGGCCCCTGGGGAGCTGCAGCAGCTGGCCCAGGGGCCGGAGGACGAGCTGGAGGATCTGCAGCTCTCAGAGGACGACTGAGGCAGCCCATCTGGGGGGCCTGTAGGGGCTGCCGGGCTGGTGGCCAGTGTTTCCACCTCCCTGGCAGTCAGGCCTAGAGGCTGGCGTCTGTGCAGTTGGGGGAGGCAGTAGACACGGGACAGGCTTTATTATTTATTTTTCAGCATGAAAGACCAAACGTATCGAGAGCTGGGCTGGGCTGGGCTGGTGTGGCTGCTGAAGCCCCACAGCTGTGGGCTGCTGAAGTCAGCTCCGCGGGGGAGCTGACCCTGACGTCAGCAGACCGAGACCAGTCCCAGTTCCAGGGGGAGGCCTGCAGGCCCCTGGCCCCTTCCACCACCTCTGCCCTCCGTCTGCAGACCTCGTCCATCTGCACCAGGCTCTGCCTTCACTCCCCCAAGTCTTTGAAAATTTGTTCCTTTCCTTTGAAGTCACATTTTCTTTTAAAATTTTTTGTTTTGCATCCGAAACCGAAAGAAATAAAGCGGTGGGAGGCAGGGCCATTGTGTT
2: GCTTCGGGTTGGTGTC^ATGGCAGCTGCGGGGAGCCGCAAGAG|GCGCCTGGCGGAGCTGACGGTGGACGAGTTCCTAGCTTCGGGCTTTGACTCCGAGTCCGAATCCGAGTCCGAAAATTCTCCACAAGCGGAGACACGGGAAGCACGCGAGGCTGCCCGGAGTCCGGATAAGCCGGGCGGGAGCCCCTCGGCCAG|CCGGCGTAAAGGCCGTGCCTCTGAGCACAAAGACCAGCTCTCTCGGCTGAAGGACAGAGACCCCGAGTTCTACAAGTTCCTGCAGGAGAATGACCAGAGCCTGCTAAACTTCAGCGACTCGGACAGCTCTGAGGAGGAAGAGGGGCCGTTCCACTCCCTGCCAGATGTGCTGGAG|GAAGCCAGTGAGGAGGAGGATGGAGCGGAGGAAGGAGAAGATGGGGACAGAGTCCCCAGAGGGCTGAAGGGGAAGAAGAATTCTGTTCCTGTGACCGTCGCCATGGTTGAGAGATGGAAGCAGGCAGCAAAG|CAACGCCTCACTCCAAAGCTGTTCCATGAAGTGGTACAGGCGTTCCGAGCAGCTGTGGCCACCACCCGAGGGGACCAGGAAAGTGCTGAGGCCAACAAATTCCAGGTCACGGACAGTGCTG|CATTCAATGCTCTGGTTACCTTCTGCATCAGAGACCTCATTGGCTGTCTCCAGAAGCTGCTGTTTGGAAAGGTGGCAAAGGATAGCAGCAG|GATGCTGCAGCCGTCCAGCAGCCCGCTCTGGGGGAAGCTTCGTGTGGACATCAAGGCTTACCTGGGCTCGGCCATACAG|CTGGTGTCCTGTCTGTCGGAGACGACGGTGTTGGCGGCCGTGCTGCGGCACATCAGCGTGCTGGTGCCCTGCTTCCTGACCTTCCCCAAGCAGTGCCGCATGCTGCTCAAG|AGAATGGTGATCGTATGGAGCACTGGGGAAGAGTCTCTGCGGGTGCTGGCTTTCCTGGTCCTCAGCAGAGTCTGCCGGCACAAGAAGGACACTTTCCTTGGCCCCGTCCTCAAG|TTTCATGCAGTGGACCTTGACGGAGCTGCTGGCCCTGGAGCCGGGTGTGGCCTACCAGCACGCCTTCCTCTACATCCGCCAGCTCGCCATACACCTGCGCAACGCCATGACCACTCGCAAGAAG|GAAACATACCAGTCTGTGTACAACTGGCAGTATGTGCACTGCCTCTTCCTGTGGTGCCGGGTCCTGAGCACTGCGGGCCCCAGCGAAGCCCTCCAGCCCTTGGTCTACCCCCTTGCCCAAGTCATCATTGGCTGTATCAA|GCTCATCCCCACTGCCCGCTTCTACCCGCTGCGAATGCACTGCATCCGTGCCCTGACGCTGCTCTCGGGGAGCTCGGGGGCCTTCATCCCGGTGCTGCCTTTCATCCTGGAG|ATGTTCCAGCAGGTCGACTTCAACAGGAAGCCAGGGCGCATGAGCTCCAAGCCCATCAACTTCTCCGTGATCCTGAAGCTGTCCAATGTCAACCTGCAGGAGAAGGCGTACCGG|GACGGCCTGGTGGAGCAGCTGTACGACCTCACCCTGGAGTACCTGCACAGCCAGGCACACTGCATCGGCTTCCCGGAGCTGGTGCTGCCTGTGGTCCTGCAG|CTGAAGTCGTTCCTCCGGGAGTGCAAGGTGGCCAACTACTGCCGGCAGGTGCAGCAGCTGCTTGGGAAGGTTCAGGAGAACTCGGCATACATCTGCAGCCGCCGCCAGAGGGTTTCCTTCGGCGTCTCTGA*GCAGCAGGCAGTG|GAAGCCTGGGAGAAGCTGACCCGGGAAGAGGGGACACCCCTGACCTTGTACTACAGCCACTGGCGCAAGCTGCGTGACCGGGAGATCCAGCTGGAGATCAGTGGCAAAGAGCGG|CTGGAAGACCTGAACTTCCCTGAGATCAAACGAAGGAAGATGGCTGACAGGAAGGATGAGGACAGGAAGCAATTTAAAGACCTCTTTGACCTGAACAGCTCTGAAGAGGACGACACCGAGGGATTCTCGGAGAGAG|GGATACTGAGGCCCCTGAGCACTCGGCATGGGGTGGAAGACGATGAAGAGGACGAGGAGGAGGGCGAGGAGGACAGCAGCAACTCGGAGGGTGAATGGTCTTGGGGTGAGAGGGTGTGGCCCTGTGAGCCCATCTGGCGGGAGGGCAGAGCCACGTGGGCGGGGGGCGTGGGGCTCTGGGCCAGGCTTTTCCCTCCCTGGGAAGGCCAGGCCAAATGCTCTGTTCTCTGGCAGCCAGCAACAGGGATAAATTAATTAGTGCCGTGATTAATTAGTGATGAGTAACCTCTAAGGCTGGCTTCTTCCTGATAAAGCAAAATTTATGTAGCCTCCATCTCTCCCCGCAGATGGAGACCCAGACGCAGAGGCGGGGCTGGCCCCTGGGGAGCTGCAGCAGCTGGCCCAGGGGCCGGAGGACGAGCTGGAGGATCTGCAGCTCTCAGAGGACGACTGAGGCAGCCCATCTGGGGGGCCTGTAGGGGCTGCCGGGCTGGTGGCCAGTGTTTCCACCTCCCTGGCAGTCAGGCCTAGAGGCTGGCGTCTGTGCAGTTGGGGGAGGCAGTAGACACGGGACAGGCTTTATTATTTATTTTTCAGCATGAAAGACCAAACGTATCGAGAGCTGGGCTGGGCTGGGCTGGTGTGGCTGCTGAAGCCCCACAGCTGTGGGCTGCTGAAGTCAGCTCCGCGGGGGAGCTGACCCTGACGTCAGCAGACCGAGACCAGTCCCAGTTCCAGGGGGAGGCCTGCAGGCCCCTGGCCCCTTCCACCACCTCTGCCCTCCGTCTGCAGACCTCGTCCATCTGCACCAGGCTCTGCCTTCACTCCCCCAAGTCTTTGAAAATTTGTTCCTTTCCTTTGAAGTCACATTTTCTTTTAAAATTTTTTGTTTTGCATCCGAAACCGAAAGAAATAAAGCGGTGGGAGGCAGGGCCATTGTG
3: GCTTCGGGTTGGTGTC^ATGGCAGCTGCGGGGAGCCGCAAGAG|GCGCCTGGCGGAGCTGACGGTGGACGAGTTCCTAGCTTCGGGCTTTGACTCCGAGTCCGAATCCGAGTCCGAAAATTCTCCACAAGCGGAGACACGGGAAGCACGCGAGGCTGCCCGGAGTCCGGATAAGCCGGGCGGGAGCCCCTCGGCCAG|CCGGCGTAAAGGCCGTGCCTCTGAGCACAAAGACCAGCTCTCTCGGCTGAAGGACAGAGACCCCGAGTTCTACAAGTTCCTGCAGGAGAATGACCAGAGCCTGCTAAACTTCAGCGACTCGGACAGCTCTGAGGAGGAAGAGGGGCCGTTCCACTCCCTGCCAGATGTGCTGGAG|GAAGCCAGTGAGGAGGAGGATGGAGCGGAGGAAGGAGAAGATGGGGACAGAGTCCCCAGAGGGCTGAAGGGGAAGAAGAATTCTGTTCCTGTGACCGTCGCCATGGTTGAGAGATGGAAGCAGGCAGCAAAG|CAACGCCTCACTCCAAAGCTGTTCCATGAAGTGGTACAGGCGTTCCGAGCAGCTGTGGCCACCACCCGAGGGGACCAGGAAAGTGCTGAGGCCAACAAATTCCAGGTCACGGACAGTGCTG|CATTCAATGCTCTGGTTACCTTCTGCATCAGAGACCTCATTGGCTGTCTCCAGAAGCTGCTGTTTGGAAAGGTGGCAAAGGATAGCAGCAG|GATGCTGCAGCCGTCCAGCAGCCCGCTCTGGGGGAAGCTTCGTGTGGACATCAAGGCTTACCTGGGCTCGGCCATACAG|CTGGTGTCCTGTCTGTCGGAGACGACGGTGTTGGCGGCCGTGCTGCGGCACATCAGCGTGCTGGTGCCCTGCTTCCTGACCTTCCCCAAGCAGTGCCGCATGCTGCTCAAG|AGAATGGTGATCGTATGGAGCACTGGGGAAGAGTCTCTGCGGGTGCTGGCTTTCCTGGTCCTCAGCAGAGTCTGCCGGCACAAGAAGGACACTTTCCTTGGCCCCGTCCTCAAG|CAAATGTACATCACGTATGTGAGGAACTGCAAGTTCACCTCGCCTGGTGCCCTCCCCTTCATCAGTTTCATGCAGTGGACCTTGACGGAGCTGCTGGCCCTGGAGCCGGGTGTGGCCTACCAGCACGCCTTCCTCTACATCCGCCAGCTCGCCATACACCTGCGCAACGCCATGACCACTCGCAAGAAG|GAAACATACCAGTCTGTGTACAACTGGCAGTATGTGCACTGCCTCTTCCTGTGGTGCCGGGTCCTGAGCACTGCGGGCCCCAGCGAAGCCCTCCAGCCCTTGGTCTACCCCCTTGCCCAAGTCATCATTGGCTGTATCAA|GCTCATCCCCACTGCCCGCTTCTACCCGCTGCGAATGCACTGCATCCGTGCCCTGACGCTGCTCTCGGGGAGCTCGGGGGCCTTCATCCCGGTGCTGCCTTTCATCCTGGAG|ATGTTCCAGCAGGTCGACTTCAACAGGAAGCCAGGGCGCATGAGCTCCAAGCCCATCAACTTCTCCGTGATCCTGAAGCTGTCCAATGTCAACCTGCAGGAGAAGGCGTACCGG|GACGGCCTGGTGGAGCAGCTGTACGACCTCACCCTGGAGTACCTGCACAGCCAGGCACACTGCATCGGCTTCCCGGAGCTGGTGCTGCCTGTGGTCCTGCAG|CTGAAGTCGTTCCTCCGGGAGTGCAAGGTGGCCAACTACTGCCGGCAGGTGCAGCAGCTGCTTGGGAAGGTTCAGGAGAACTCGGCATACATCTGCAGCCGCCGCCAGAGGGTTTCCTTCGGCGTCTCTGAGCAGCAGGCAGTG|GAAGCCTGGGAGAAGCTGACCCGGGAAGAGGGGACACCCCTGACCTTGTACTACAGCCACTGGCGCAAGCTGCGTGACCGGGAGATCCAGCTGGAGATCAGTGGCAAAGAGCGG|CTGGAAGACCTGAACTTCCCTGAGATCAAACGAAGGAAGATGGCTGACAGGAAGGATGAGGACAGGAAGCAATTTAAAGACCTCTTTGACCTGAACAGCTCTGAAGAGGACGACACCGAGGGATTCTCGGAGAGAG|GGATACTGAGGCCCCTGAGCACTCGGCATGGGGTGGAAGACGATGAAGAGGACGAGGAGGAGGGCGAGGAGGACAGCAGCAACTCGGAGG|ATGGAGACCCAGACGCAGAGGCGGGGCTGGCCCCTGGGGAGCTGCAGCAGCTGGCCCAGGGGCCGGAGGACGAGCTGGAGGATCTGCAGCTCTCAGAGGACGACTGA*GGCAGCCCATCTGGGGGGCCTGTAGGGGCTGCCGGGCTGGTGGCCAGTGTTTCCACCTCCCTGGCAGTCAGGCCTAGAGGCTGGCGTCTGTGCAGTTGGGGGAGGCAGTAGACACGGGACAGGCTTTATTATTTATTTTTCAGCATGAAAGACCAAACGTATCGAGAGCTGGGCTGGGCTGGGCTGGTGTGGCTGCTGAAGCCCCACAGCTGTGGGCTGCTGAAGTCAGCTCCGCGGGGGAGCTGACCCTGACGTCAGCAGACCGAGACCAGTCCCAGTTCCAGGGGGAGGCCTGCAGGCCCCTGGCCCCTTCCACCACCTCTGCCCTCCGTCTGCAGACCTCGTCCATCTGCACCAGGCTCTGCCTTCACTCCCCCAAGTCTTTGAAAATTTGTTCCTTTCCTTTGAAGTCACATTTTCTTTTAAAATTTTTTGTTTTGCATCCGAAACCGAAAGAAATAAAGCGGTGGGAGGCAGGGCCAT
4: GCTTCGGGTTGGTGTC^ATGGCAGCTGCGGGGAGCCGCAAGAG|GCGCCTGGCGGAGCTGACGGTGGACGAGTTCCTAGCTTCGGGCTTTGACTCCGAGTCCGAATCCGAGTCCGAAAATTCTCCACAAGCGGAGACACGGGAAGCACGCGAGGCTGCCCGGAGTCCGGATAAGCCGGGCGGGAGCCCCTCGGCCAG|CCGGCGTAAAGGCCGTGCCTCTGAGCACAAAGACCAGCTCTCTCGGCTGAAGGACAGAGACCCCGAGTTCTACAAGTTCCTGCAGGAGAATGACCAGAGCCTGCTAAACTTCAGCGACTCGGACAGCTCTGAGGAGGAAGAGGGGCCGTTCCACTCCCTGCCAGATGTGCTGGAG|GAAGCCAGTGAGGAGGAGGATGGAGCGGAGGAAGGAGAAGATGGGGACAGAGTCCCCAGAGGGCTGAAGGGGAAGAAGAATTCTGTTCCTGTGACCGTCGCCATGGTTGAGAGATGGAAGCAGGCAGCAAAG|CAACGCCTCACTCCAAAGCTGTTCCATGAAGTGGTACAGGCGTTCCGAGCAGCTGTGGCCACCACCCGAGGGGACCAGGAAAGTGCTGAGGCCAACAAATTCCAGGTCACGGACAGTGCTG|CATTCAATGCTCTGGTTACCTTCTGCATCAGAGACCTCATTGGCTGTCTCCAGAAGCTGCTGTTTGGAAAGGTGGCAAAGGATAGCAGCAG|GATGCTGCAGCCGTCCAGCAGCCCGCTCTGGGGGAAGCTTCGTGTGGACATCAAGGCTTACCTGGGCTCGGCCATACAG|CTGGTGTCCTGTCTGTCGGAGACGACGGTGTTGGCGGCCGTGCTGCGGCACATCAGCGTGCTGGTGCCCTGCTTCCTGACCTTCCCCAAGCAGTGCCGCATGCTGCTCAAG|AGAATGGTGATCGTATGGAGCACTGGGGAAGAGTCTCTGCGGGTGCTGGCTTTCCTGGTCCTCAGCAGAGTCTGCCGGCACAAGAAGGACACTTTCCTTGGCCCCGTCCTCAAG|CAAATGTACATCACGTATGTGAGGAACTGCAAGTTCACCTCGCCTGGTGCCCTCCCCTTCATCAGTTTCATGCAGTGGACCTTGACGGAGCTGCTGGCCCTGGAGCCGGGTGTGGCCTACCAGCACGCCTTCCTCTACATCCGCCAGCTCGCCATACACCTGCGCAACGCCATGACCACTCGCAAGAAG|GAAACATACCAGTCTGTGTACAACTGGCAGTATGTGCACTGCCTCTTCCTGTGGTGCCGGGTCCTGAGCACTGCGGGCCCCAGCGAAGCCCTCCAGCCCTTGGTCTACCCCCTTGCCCAAGTCATCATTGGCTGTATCAA|GCTCATCCCCACTGCCCGCTTCTACCCGCTGCGAATGCACTGCATCCGTGCCCTGACGCTGCTCTCGGGGAGCTCGGGGGCCTTCATCCCGGTGCTGCCTTTCATCCTGGAG|CAGGTCGACTTCAACAGGAAGCCAGGGCGCATGAGCTCCAAGCCCATCAACTTCTCCGTGATCCTGAAGCTGTCCAATGTCAACCTGCAGGAGAAGGCGTACCGG|GACGGCCTGGTGGAGCAGCTGTACGACCTCACCCTGGAGTACCTGCACAGCCAGGCACACTGCATCGGCTTCCCGGAGCTGGTGCTGCCTGTGGTCCTGCAG|CTGAAGTCGTTCCTCCGGGAGTGCAAGGTGGCCAACTACTGCCGGCAGGTGCAGCAGCTGCTTGGGAAGGTTCAGGAGAACTCGGCATACATCTGCAGCCGCCGCCAGAGGGTTTCCTTCGGCGTCTCTGAGCAGCAGGCAGTG|GAAGCCTGGGAGAAGCTGACCCGGGAAGAGGGGACACCCCTGACCTTGTACTACAGCCACTGGCGCAAGCTGCGTGACCGGGAGATCCAGCTGGAGATCAGTGGCAAAGAGCGG|CTGGAAGACCTGAACTTCCCTGAGATCAAACGAAGGAAGATGGCTGACAGGAAGGATGAGGACAGGAAGCAATTTAAAGACCTCTTTGACCTGAACAGCTCTGAAGAGGACGACACCGAGGGATTCTCGGAGAGAG|GGATACTGAGGCCCCTGAGCACTCGGCATGGGGTGGAAGACGATGAAGAGGACGAGGAGGAGGGCGAGGAGGACAGCAGCAACTCGGAGG|ATGGAGACCCAGACGCAGAGGCGGGGCTGGCCCCTGGGGAGCTGCAGCAGCTGGCCCAGGGGCCGGAGGACGAGCTGGAGGATCTGCAGCTCTCAGAGGACGACTGA*GGCAGCCCATCTGGGGGGCCTGTAGGGGCTGCCGGGCTGGTGGCCAGTGTTTCCACCTCCCTGGCAGTCAGGCCTAGAGGCTGGCGTCTGTGCAGTTGGGGGAGGCAGTAGACACGGGACAGGCTTTATTATTTATTTTTCAGCATGAAAGACCAAACGTATCGAGAGCTGGGCTGGGCTGGGCTGGTGTGGCTGCTGAAGCCCCACAGCTGTGGGCTGCTGAAGTCAGCTCCGCGGGGGAGCTGACCCTGACGTCAGCAGACCGAGACCAGTCCCAGTTCCAGGGGGAGGCCTGCAGGCCCCTGGCCCCTTCCACCACCTCTGCCCTCCGTCTGCAGACCTCGTCCATCTGCACCAGGCTCTGCCTTCACTCCCCCAAGTCTTTGAAAATTTGTTCCTTTCCTTTGAAGTCACATTTTCTTTTAAAATTTTTTGTTTTGCATCCGAAACCGAAAGAAATAAAGCGGTGGGAGGCAGGGC
5: GGGGTGCACGCTTCGGGTTGGTGTC^ATGGCAGCTGCGGGGAGCCGCAAGAG|GCGCCTGGCGGAGCTGACGGTGGACGAGTTCCTAGCTTCGGGCTTTGACTCCGAGTCCGAATCCGAGTCCGAAAATTCTCCACAAGCGGAGACACGGGAAGCACGCGAGGCTGCCCGGAGTCCGGATAAGCCGGGCGGGAGCCCCTCGGCCAG|CCGGCGTAAAGGCCGTGCCTCTGAGCACAAAGACCAGCTCTCTCGGCTGAAGGACAGAGACCCCGAGTTCTACAAGTTCCTGCAGGAGAATGACCAGAGCCTGCTAAACTTCAGCGACTCGGACAGCTCTGAGGAGGAAGAGGGGCCGTTCCACTCCCTGCCAGATGTGCTGGAG|GAAGCCAGTGAGGAGGAGGATGGAGCGGAGGAAGGAGAAGATGGGGACAGAGTCCCCAGAGGGCTGAAGGGGAAGAAGAATTCTGTTCCTGTGACCGTCGCCATGGTTGAGAGATGGAAGCAGGCAGCAAAG|CAACGCCTCACTCCAAAGCTGTTCCATGAAGTGGTACAGGCGTTCCGAGCAGCTGTGGCCACCACCCGAGGGGACCAGGAAAGTGCTGAGGCCAACAAATTCCAGGTCACGGACAGTGCTG|CATTCAATGCTCTGGTTACCTTCTGCATCAGAGACCTCATTGGCTGTCTCCAGAAGCTGCTGTTTGGAAAGGTGGCAAAGGATAGCAGCAG|GATGCTGCAGCCGTCCAGCAGCCCGCTCTGGGGGAAGCTTCGTGTGGACATCAAGGCTTACCTGGGCTCGGCCATACAG|CTGGTGTCCTGTCTGTCGGAGACGACGGTGTTGGCGGCCGTGCTGCGGCACATCAGCGTGCTGGTGCCCTGCTTCCTGACCTTCCCCAAGCAGTGCCGCATGCTGCTCAAG|AGAATGGTGATCGTATGGAGCACTGGGGAAGAGTCTCTGCGGGTGCTGGCTTTCCTGGTCCTCAGCAGAGTCTGCCGGCACAAGAAGGACACTTTCCTTGGCCCCGTCCTCAAG|CAAATGTACATCACGTATGTGAGGAACTGCAAGTTCACCTCGCCTGGTGCCCTCCCCTTCATCAGTTTCATGCAGTGGACCTTGACGGAGCTGCTGGCCCTGGAGCCGGGTGTGGCCTACCAGCACGCCTTCCTCTACATCCGCCAGCTCGCCATACACCTGCGCAACGCCATGACCACTCGCAAGAAG|GAAACATACCAGTCTGTGTACAACTGGCAGTATGTGCACTGCCTCTTCCTGTGGTGCCGGGTCCTGAGCACTGCGGGCCCCAGCGAAGCCCTCCAGCCCTTGGTCTACCCCCTTGCCCAAGTCATCATTGGCTGTATCAA|GCTCATCCCCACTGCCCGCTTCTACCCGCTGCGAATGCACTGCATCCGTGCCCTGACGCTGCTCTCGGGGAGCTCGGGGGCCTTCATCCCGGTGCTGCCTTTCATCCTGGAG|ATGTTCCAGCAGGTCGACTTCAACAGGAAGCCAGGGCGCATGAGCTCCAAGCCCATCAACTTCTCCGTGATCCTGAAGCTGTCCAATGTCAACCTGCAGGAGAAGGCGTACCGG|GACGGCCTGGTGGAGCAGCTGTACGACCTCACCCTGGAGTACCTGCACAGCCAGGCACACTGCATCGGCTTCCCGGAGCTGGTGCTGCCTGTGGTCCTGCAG|CTGAAGTCGTTCCTCCGGGAGTGCAAGGTGGCCAACTACTGCCGGCAGGTGCAGCAGCTGCTTGGGAAGGTTCAGGAGAACTCGGCATACATCTGCAGCCGCCGCCAGAGGGTTTCCTTCGGCGTCTCTGAGCAGCAGGCAGTG|GAAGCCTGGGAGAAGCTGACCCGGGAAGAGGGGACACCCCTGACCTTGTACTACAGCCACTGGCGCAAGCTGCGTGACCGGGAGATCCAGCTGGAGATCAGTGGCAAAGAGCGG|CTGGAAGACCTGAACTTCCCTGAGATCAAACGAAGGAAGATGGCTGACAGGAAGGATGAGGACAGGAAGCAATTTAAAGACCTCTTTGACCTGAACAGCTCTGAAGAGGACGACACCGAGGGATTCTCGGAGAGAGGTGGGGCCTGCGTGGTGCTCCCAGGGGAAGGGTGGGCCTGGAGGGCTCTGCTGGACTTCCCAGAGCCACGAGGGCCACCTGTACCCATCCTGCAGGGGGCTCACCAGTCTCTGGCCCAGCTGGGGCCAACCTCAGTGTTGCCAGGCTTCTGGTGCCAGCGCCTTCCCTCCTTGAAGTGA*AGGCCTACTGGGATTGGTAACTCTGTCCCCAGGCCTGTGACCTCCCAGTTCCTCCCCAGGGCTCCTCTCCACCTGCTGGAAGTCAGCGGAGGGAAGGGTGTTGGGAGCCTGGCCACCCTCCTGCCCCCACTGTGACTTTGCTGGTGGACCCTGTGGGTGGGAGTCATATGGACTCTGCTTCTTGTTCCTCAGGGATACTGAGGCCCCTGAGCACTCGGCATGGGGTGGAAGACGATGAAGAGGACGAGGAGGAGGGCGAGGAGGACAGCAGCAACTCGGAGGGTGAATGGTCTTGGG|ATGGAGACCCAGACGCAGAGGCGGGGCTGGCCCCTGGGGAGCTGCAGCAGCTGGCCCAGGGGCCGGAGGACGAGCTGGAGGATCTGCAGCTCTCAGAGGACGACTGAGGCAGCCCATCTGGGGGGCCTGTAGGGGCTGCCGGGCTGGTGGCCAGTGTTTCCACCTCCCTGGCAGTCAGGCCTAGAGGCTGGCGTCTGTGCAGTTGGGGGAGGCAGTAGACACGGGACAGGCTTTATTATTTATTTTTCAGCATGAAAGACCAAACGTATCGAGAGCTGGGCTGGGCTGGGCTGGTGTGGCTGCTGAAGCCCCACAGCTGTGGGCTGCTGAAGTCAGCTCCGCGGGGGAGCTGACCCTGACGTCAGCAGACCGAGACCAGTCCCAGTTCCAGGGGGAGGCCTGCAGGCCCCTGGCCCCTTCCACCACCTCTGCCCTCCGTCTGCAGACCTCGTCCATCTGCACCAGGCTCTGCCTTCACTCCCCCAAGTCTTTGAAAATTTGTTCCTTTCCTTTGAAGTCACATTTTCTTTTAAAATTTTTTGTTTTGCATCCGAAACCGAAAGAAATAAAGCGGTGGGAGGCAGGG
---
106428: GCAGGGCCCGGAGGTCAAGATGGTGGCTGTAAAACTAGGATCCCTGACGATTG|CTTAGCATTAAGGCCCGAC^ATGGAACCGGGGTGTGACGAGTTCCTGCCGCCACCGGAGTGCCCGGTTTTTGAGCCTAGCTGGGCTGAATTCCAAGACCCGCTTGGCTACATTGCGAAAATAAGGCCCATAGCAGAGAAGTCTGGCATCTGCAAAATCCGCCCACCCGCG|GATTGGCAGCCTCCTTTTGCAGTAGAAGTTGACAATTTCAGATTTACTCCTCGCGTCCAAAGGCTAAATGAACTGGAG|GCCCAAACTAGAGTGAAATTGAACTATTTGGATCAGATTGCAAAATTCTGGGAAATTCAAGGCTCCTCTTTAAAGATTCCCAATGTGGAGCGGAAGATCTTGGACCTCTACAGCCTTAGTAAG|ATTGTGATTGAGGAAGGTGGCTATGAAGCCATCTGCAAGGATCGTCGGTGGGCTCGAGTTGCCCAGCGTCTCCACTACCCACCAGGCAAAAACATTGGCTCCCTGCTACGATCACATTACGAACGCATTATTTACCCCTATGAAATGTTTCAGTCTGGAGCCAACCATGTG|CAATGTAACACACACCCGTTTGACAATGAGGTAAAAGATAAGGAATACAAGCCCCACAGCATCCCCCTTAGACAGTCTGTGCAGCCTTCAAAGTTCAGCAGCTACAGTCGACGGGCAAAAAGGCTACAGCCTGAT|CCAGAGCCTACAGAGGAGGACATTGAGAAGCATCCAGAGCTAAAGAAGTTACAGATATATGGGCCAGGTCCCAAAATGATGGGCTTGGGCCTTATGGCTAAGGATAAGGATAAGACTGTGCATAAGAAAG|TCACATGCCCCCCAACTGTTACGGTGAAGGATGAGCAAAGTGGAGGTGGGAACGTGTCATCAACATTGCTCAAGCAGCACTTGAGCCTAGAGCCCTGCACTAAGACAACCATGCAACTTCGAAAGAATCACAGCAGTGCCCAGTTT|ATTGACTCATATATTTGCCAAGTATGCTCCCGTGGGGATGAAGATGATAAGCTTCTTTTCTGTGATGGCTGTGATGACAATTACCACATCTTCTGCTTGTTACCACCCCTTCCTGAAATCCCCAGAGGCATCTGGAGGTGCCCAAAATGTATCTTGGCG|GAGTGTAAACAGCCTCCTGAAGCTTTTGGATTTGAACAGGCTACCCAGGAGTACAGTTTGCAGAGTTTTGGTGAAATGGCTGATTCCTTCAAGTCCGACTACTTCAACATGCCTGTACAT|ATGGTGCCTACAGAACTTGTAGAGAAGGAATTCTGGAGGCTGGTGAGCAGCATTGAGGAAGACGTGACAGTTGAATATGGAGCTGATATTCATTCCAAAGAATTTGGCAGTGGCTTTCCTGTCAGCAATAGCAAACAAAACTTATCTCCTGAGGAGAAG|GAGTATGCGACCAGTGGTTGGAACCTGAATGTGATGCCAGTGCTAGATCAGTCTGTTCTCTGTCACATCAATGCAGACATCTCAGGCATGAAGGTGCCCTGGCTGTACGTGGGCATGGTTTTCTCAGCATTTTGTTGGCATATTGAGGATCACTGGAGTTACTCTATTAACTATCTGCATTG|GGGTGAGCCGAAGACCTGGTATGGTGTACCCTCCCTGGCAGCAGAGCATTTGGAGGAGGTGATGAAGATGCTGACACCTGAGCTGTTTGATAGCCAGCCTGATCTCCTACACCAGCTTGTCACTCTCATGAATCCCAACACTTTGATGTCCCATGGTGTGCCA|GTTGTCCGCACAAACCAGTGTGCAGGGGAGTTTGTCATCACTTTTCCTCGTGCTTACCACAGTGGTTTTAACCAAGGCTACAATTTTGCTGAAGCTGTCAACTTTTGTACTGCTGACTGG|CTACCTGCTGGACGCCAGTGCATTGAACACTACCGCCGGCTCCGGCGCTATTGTGTCTTCTCCCACGAGGAGCTCATCTGCAAGATGGCTGCCTTCCCAGAGACGTTGGATCTCAATCTAGCAGTAGCTGTGCACAAGGAGATGTTCATTATGGTTCAGGAGGAGCGACGTCTACGAAAGGCCCTTTTGGAGAAG|GGCGTCACGGAGGCTGAGCGAGAGGCTTTTGAGCTGCTCCCAGATGATGAACGCCAGTGCATCAAGTGCAAGACCACGTGCTTCTTGTCAGCCCTGGCCTGCTACGACTGCCCAGATGGCCTTGTATGCCTTTCCCACATCAATGACCTCTGCAAGTGCTCTAGTAGCCGACAGTACCTCCG|GTATCGGTACACCTTGGATGAGCTCCCCACCATGCTGCATAAACTGAAGATTCGGGCTGAGTCTTTTGACACCTGGGCCAACAAAGTGCGAGTGGCCTTGGAGGTGGAGGATGGCCGTAAACGCA|GCTTTGAAGAGCTAAGGGCACTGGAGTCTGAGGCTCGTGAGAGGAGGTTTCCTAATAGTGAGCTGCTTCAGCGACTGAAGAACTGCCTGAGTGAGGTGGAGGCTTGTATTGCTCAAGTCCTGGGGCTGGTCAGTGGTCAGGTGGCCAG|GATGGACACTCCACAGCTGACCTTGACTGAACTCCGGGTCCTTCTTGAGCAGATGGGCAGCCTGCCCTGTGCCATGCATCAGATTGGGGATGTCAAG|GTTCTTTCCTGGAAGTGGCGGAGATATGTGTTCCCATACCATCTCTGTGTGTACAGCATGCAAGGAAATATCCTTCCAGACTGA*AATAATTAAAAACTCTAAACTGGGCCTACATAAGACACTGGCTCTTGGGAATGGGGTGGAGAGGACTGATTGGTTGGTTGGTTGATTTCCCTCCAGACACCAGAGTCTTAGAAAGCTTACTAGATGGATAAGATTGTATTAAAGTGGGTTTGGAAAAAGAAATTTAGGTAATTAAAGGAGAAAAATGTCATTCTAGGTAAACAGAGGGCCTTTGTTATTATCAGATAGATCATGTTTTAGGATGTGGTTGAGAATAAGTATTAAGCAATAGGAAATGCCTATAAGAGAAGATGAGAAGTGGAGCAAATCTAGGTGGTTGAGTATTTATGTGGCTAAAGAATCTGCATTTTATCCTATGTCCTTGCAGGATGTCCTGGAACAGGTGGAGGCCTATCAAGCTGAGGCTCGTGAGGCTCTGGCCACACTGCCCTCTAGTCCAGGGCTATTGCGGTCCCTGTTGGAGAGGGGGCAGCAGCTGGGTGTAGAGGTGCCTGAAGCCCATCAGCTTCAGCAGCAGGTGGAGCAGGCGCAATGGCTAGATGAAGTGAAGCAGGCCCTGGCCCCTTCTGCTCACAGGGGCTCTCTGGTCATCATGCAGGGGCTTTTGGTTATGGGTGCCAAGATAGCCTCCAGCCCTTCTGTGGACAAGGCCCGGGCTGAGCTGCAAGAACTACTGACCATTGCAGAGCGCTGGGAAGAAAAGGCTCATTTCTGCCTGGAGGCCAG|GCAGAAGCATCCACCAGCCACATTGGAAGCCATAATTCGTGAGACAGAAAACATCCCTGTTCACCTGCCTAACATCCAGGCTCTCAAAGAAGCTCTGACTAAGGCACAAGCTTGGATTGCTGATGTGGATGAGATCCAA|AATGGTGACCACTACCCCTGTCTAGATGACTTGGAGGGCCTGGTGGCTGTGGGCCGGGACCTGCCTGTGGGGCTGGAAGAGCTGAGACAGCTAGAGCTGCAGGTATTGACAGCACATTCCTGGAGAGAGAAGGCCTCCAAGACCTTTCTCAAGAAGAATTCTTGCTACACACTGCTTGAG|GTGCTTTGCCCGTGTGCAGACGCTGGCTCAGACAGCACCAAGCGTAGCCGGTGGATGGAGAAGGCGCTGGGGTTGTACCAGTGTGACACAGAGCTGCTGGGGCTGTCTGCACAGGACCTCAGAGACCCAGGCTCTGTG|ATTGTGGCCTTCAAGGAAGGGGAACAGAAGGAGAAGGAGGGTATCCTGCAGCTGCGTCGCACCAACTCAGCCAAGCCCAGTCCACTGGCACCATCCCTCATGGCCTCTTCTCCGACTTCTATCTGTGTGTGTGGGCAGGTGCCAGCTGGGGTGGGAGTTCTGCAGTGTGACCTGTGTCAGGACTGGTTCCATGGGCAGTGTGTGTCAGTGCCCCATCTCCTCACCTCTCCAAAGCCCAGTCTCACTTCATCTCCACTGCTAGCCTGGTGGGAATGGGACACAAAATTCCTGTGTCCACTGTGTATGCGCTCACGACGGCCACGCCTAGAGACAATCCTAGCCTTGCTGGTTGCCCTGCAGAGGCTGCCCGTGCGGCTGCCTGAGGGTGAGGCCCTTCAGTGTCTCACAGAGAGGGCCATTGGCTGGCAAGACCGTGCCAGAAAGGCTCTGGCCTCTGAAGATGTGACTGCTCTGTTGCGACAGCTGGCTGAGCTTCGCCAACAGCTACAGGCCAAACCCAGACCAGAGGAGGCCTCAGTCTACACTTCAGCCACTGCCTGTGACCCTATCAGAGAAGGCAGTGGCAACAATATTTCTAAG|GTCCAAGGGCTGCTGGAGAATGGAGACAGTGTGACCAGTCCTGAGAACATGGCTCCAGGAAAGGGCTCTG|TTGACTGGCCCTGTGTTGGAGCTGCCTGAGGCAATCCGGGCTCCCCTGGAGGAGCTCATGATGGAAGGGGACCTGCTTGAGGTGACCCTGGATGAGAACCACAGCATCTGGCAGCTGCTGCAGGCTGGACAGCCTCCAGACCTGGACAGAATTCGCACACTTCTGGAG|CTGGAAAAATTTGAACATCAAGGGAGTCGGACAAGGAGCCGGGCTCTGGAGAGGCGACGGCGGCGGCAGAAGGTGGATCAGGGTAGAAACGTTGAGAATCTTGTTCAACAGGAGCTTCAGTCAAAAAGGGCTCGGAGCTCAGGGATTATGTCTCAGGTGGGCCGAGAAGAAGAACATTATCAGGAGAAAGCAGACCGTGAAAATATGTTCCTGACACCTTCCACAGACCACAGCCCTTTCTTGAAAGGAAACCAAAATAGCTTACAACACAAGGATTCAGGCTCTTCAGCTGCTTGTCCTTCTTTAATGCCTTTGCTACAACTCTCCTACTCTGATGAGCAACAGTTGTGACAGTGGCACCAAAGGTCATTTGTGGTTGTTTTTGTTTGTTTGTTTCTTAAATCCTACTATCTCCTGGCCTGGACCTCAGAAGGAGCTTTTTGCTTATCTATAATTTTTCACTGCCAATTTTTGATATCCTCTCTCCTAGAGTTACTGTTAAAAGGTTGGTTCGTAAAGTCCACACCCCGATGCTCAGAAGTGTCTTGCCAGCAACATTCCTGCTAGCATACAGGAGTGATTTCCTAAACCAGTTTCATTCTAGTCTGAATAGGGACAAACAAATCTTGAGGAAGCCCAAGTGCGTACCTTTATTTTTGCCCCCACCACCCTCTTTCTGTACTTCAATTTTTGTTTGTTTTTTGTTTTTTTGTCCCTGTCATAAAATATTTTGGTGCTTCAAAACTTGTACCTTCATTGTACATCCTTTTCTTTTCTCCCCTTGGGTCTTATTATAAAAGAAGACAATGTACGTTGTAATTACCAAAAAGAATAGGGAAAAACAAGAATTTCATGACTCTACCTGTGGTCTATCTTTAATTTCATTTCTTTTGTTAAAAATAAAACAATGAGTATGTTTGGATACTATGAA
106429: ACTGCAGGGCCCGGAGGTCAAGATGGTGGCTGTAAAACTAGGATCCCTGACGATTG|CTTAGCATTAAGGCCCGACATGGAACCGGGGTGTGACGAGTTCCTGCCGCCACCGGAGTGCCCGGTTTTTGAGCCTAGCTGGGCTGAATTCCAAGACCCGCTTGGCTACATTGCGAAAATAAGGCCCATAGCAGAGAAGTCTGGCATCTGCAAAATCCGCCCACCCGCG|GATTGGCAGCCTCCTTTTGCAGTAGAAGTTGACAATTTCAGATTTACTCCTCGCGTCCAAAGGCTAAATGAACTGGAG|GCCCAAACTAGAGTGAAATTGAACTATTTGGATCAGATTGCAAAATTCTGGGAAATTCAAGGCTCCTCTTTAAAGATTCCCAATGTGGAGCGGAAGATCTTGGACCTCTACAGCCTTAGTAAG|ATTGTGATTGAGGAAGGTGGCTATGAAGCCATCTGCAAGGATCGTCGGTGGGCTCGAGTTGCCCAGCGTCTCCACTACCCACCAGGCAAAAACATTGGCTCCCTGCTACGATCACATTACGAACGCATTATTTACCCCTATGAAATGTTTCAGTCTGGAGCCAACCATGTG|CAATGTAACACACACCCGTTTGACAATGAGGTAAAAGATAAGGAATACAAGCCCCACAGCATCCCCCTTAGACAGTCTGTGCAGCCTTCAAAGTTCAGCAGCTACAGTCGACGGGCAAAAAGGCTACAGCCTGAT|CCAGAGCCTACAGAGGAGGACATTGAGAAGCATCCAGAGCTAAAGAAGTTACAGATATATGGGCCAGGTCCCAAAATGATGGGCTTGGGCCTTATGGCTAAGGATAAGGATAAGACTGTGCATAAGAAAG|TCACATGCCCCCCAACTGTTACGGTGAAGGATGAGCAAAGTGGAGGTGGGAACGTGTCATCAACATTGCTCAAGCAGCACTTGAGCCTAGAGCCCTGCACTAAGACAACCATGCAACTTCGAAAGAATCACAGCAGTGCCCAGTTT|ATTGACTCATATATTTGCCAAGTATGCTCCCGTGGGGATGAAGATGATAAGCTTCTTTTCTGTGATGGCTGTGATGACAATTACCACATCTTCTGCTTGTTACCACCCCTTCCTGAAATCCCCAGAGGCATCTGGAGGTGCCCAAAATGTATCTTGGCG|GAGTGTAAACAGCCTCCTGAAGCTTTTGGATTTGAACAGGCTACCCAGGAGTACAGTTTGCAGAGTTTTGGTGAAATGGCTGATTCCTTCAAGTCCGACTACTTCAACATGCCTGTACAT|ATGGTGCCTACAGAACTTGTAGAGAAGGAATTCTGGAGGCTGGTGAGCAGCATTGAGGAAGACGTGACAGTTGAATATGGAGCTGATATTCATTCCAAAGAATTTGGCAGTGGCTTTCCTGTCAGCAATAGCAAACAAAACTTATCTCCTGAGGAGAAG|GAGTATGCGACCAGTGGTTGGAACCTGAATGTGATGCCAGTGCTAGATCAGTCTGTTCTCTGTCACATCAATGCAGACATCTCAGGCATGAAGGTGCCCTGGCTGTACGTGGGCATGGTTTTCTCAGCATTTTGTTGGCATATTGAGGATCACTGGAGTTACTCTATTAACTATCTGCATTG|GGGTGAGCCGAAGACCTGGTATGGTGTACCCTCCCTGGCAGCAGAGCATTTGGAGGAGGTGATGAAGATGCTGACACCTGAGCTGTTTGATAGCCAGCCTGATCTCCTACACCAGCTTGTCACTCTCATGAATCCCAACACTTTGATGTCCCATGGTGTGCCA|GTTGTCCGCACAAACCAGTGTGCAGGGGAGTTTGTCATCACTTTTCCTCGTGCTTACCACAGTGGTTTTAACCAAGGCTACAATTTTGCTGAAGCTGTCAACTTTTGTACTGCTGACTGGGTGAGTGAGCATGCAGTGGGCCTGCAGGTAGAAAGTATAAAGAATATGGGTAAGGATTATTGTGGAGAAGCTATGCATTGTGGTCTCCAGATAGCCACACACAATCTTGAACGCACTTGCAGCTACCTGCTGGACGCCAGTGCATTGAACACTACCGCCGGCTCCGGCGCTATTGTGTCTTCTCCCACGAGGAGCTCATCTGCAAG^ATGGCTGCCTTCCCAGAGACGTTGGATCTCAATCTAGCAGTAGCTGTGCACAAGGAGATGTTCATTATGGTTCAGGAGGAGCGACGTCTACGAAAGGCCCTTTTGGAGAAG|GGCGTCACGGAGGCTGAGCGAGAGGCTTTTGAGCTGCTCCCAGATGATGAACGCCAGTGCATCAAGTGCAAGACCACGTGCTTCTTGTCAGCCCTGGCCTGCTACGACTGCCCAGATGGCCTTGTATGCCTTTCCCACATCAATGACCTCTGCAAGTGCTCTAGTAGCCGACAGTACCTCCG|GTATCGGTACACCTTGGATGAGCTCCCCACCATGCTGCATAAACTGAAGATTCGGGCTGAGTCTTTTGACACCTGGGCCAACAAAGTGCGAGTGGCCTTGGAGGTGGAGGATGGCCGTAAACGCA|GCTTTGAAGAGCTAAGGGCACTGGAGTCTGAGGCTCGTGAGAGGAGGTTTCCTAATAGTGAGCTGCTTCAGCGACTGAAGAACTGCCTGAGTGAGGTGGAGGCTTGTATTGCTCAAGTCCTGGGGCTGGTCAGTGGTCAGGTGGCCAG|GATGGACACTCCACAGCTGACCTTGACTGAACTCCGGGTCCTTCTTGAGCAGATGGGCAGCCTGCCCTGTGCCATGCATCAGATTGGGGATGTCAAG|GATGTCCTGGAACAGGTGGAGGCCTATCAAGCTGAGGCTCGTGAGGCTCTGGCCACACTGCCCTCTAGTCCAGGGCTATTGCGGTCCCTGTTGGAGAGGGGGCAGCAGCTGGGTGTAGAGGTGCCTGAAGCCCATCAGCTTCAGCAGCAGGTGGAGCAGGCGCAATGGCTAGATGAAGTGAAGCAGGCCCTGGCCCCTTCTGCTCACAGGGGCTCTCTGGTCATCATGCAGGGGCTTTTGGTTATGGGTGCCAAGATAGCCTCCAGCCCTTCTGTGGACAAGGCCCGGGCTGAGCTGCAAGAACTACTGACCATTGCAGAGCGCTGGGAAGAAAAGGCTCATTTCTGCCTGGAGGCCAG|GCAGAAGCATCCACCAGCCACATTGGAAGCCATAATTCGTGAGACAGAAAACATCCCTGTTCACCTGCCTAACATCCAGGCTCTCAAAGAAGCTCTGACTAAGGCACAAGCTTGGATTGCTGATGTGGATGAGATCCAA|AATGGTGACCACTACCCCTGTCTAGATGACTTGGAGGGCCTGGTGGCTGTGGGCCGGGACCTGCCTGTGGGGCTGGAAGAGCTGAGACAGCTAGAGCTGCAGGTATTGACAGCACATTCCTGGAGAGAGAAGGCCTCCAAGACCTTTCTCAAGAAGAATTCTTGCTACACACTGCTTGAG|GTGCTTTGCCCGTGTGCAGACGCTGGCTCAGACAGCACCAAGCGTAGCCGGTGGATGGAGAAGGCGCTGGGGTTGTACCAGTGTGACACAGAGCTGCTGGGGCTGTCTGCACAGGACCTCAGAGACCCAGGCTCTGTG|ATTGTGGCCTTCAAGGAAGGGGAACAGAAGGAGAAGGAGGGTATCCTGCAGCTGCGTCGCACCAACTCAGCCAAGCCCAGTCCACTGGCACCATCCCTCATGGCCTCTTCTCCGACTTCTATCTGTGTGTGTGGGCAGGTGCCAGCTGGGGTGGGAGTTCTGCAGTGTGACCTGTGTCAGGACTGGTTCCATGGGCAGTGTGTGTCAGTGCCCCATCTCCTCACCTCTCCAAAGCCCAGTCTCACTTCATCTCCACTGCTAGCCTGGTGGGAATGGGACACAAAATTCCTGTGTCCACTGTGTATGCGCTCACGACGGCCACGCCTAGAGACAATCCTAGCCTTGCTGGTTGCCCTGCAGAGGCTGCCCGTGCGGCTGCCTGAGGGTGAGGCCCTTCAGTGTCTCACAGAGAGGGCCATTGGCTGGCAAGACCGTGCCAGAAAGGCTCTGGCCTCTGAAGATGTGACTGCTCTGTTGCGACAGCTGGCTGAGCTTCGCCAACAGCTACAGGCCAAACCCAGACCAGAGGAGGCCTCAGTCTACACTTCAGCCACTGCCTGTGACCCTATCAGAGAAGGCAGTGGCAACAATATTTCTAAG|GTCCAAGGGCTGCTGGAGAATGGAGACAGTGTGACCAGTCCTGAGAACATGGCTCCAGGAAAGGGCTCTG|ACCTGGAGCTACTGTCCTCACTGTTGCCGCAGTTGACTGGCCCTGTGTTGGAGCTGCCTGAGGCAATCCGGGCTCCCCTGGAGGAGCTCATGATGGAAGGGGACCTGCTTGAGGTGACCCTGGATGAGAACCACAGCATCTGGCAGCTGCTGCAGGCTGGACAGCCTCCAGACCTGGACAGAATTCGCACACTTCTGGAG|CTGGAAAAATTTGAACATCAAGGGAGTCGGACAAGGAGCCGGGCTCTGGAGAGGCGACGGCGGCGGCAGAAGGTGGATCAGGGTAGAAACGTTGAGAATCTTGTTCAACAGGAGCTTCAGTCAAAAAGGGCTCGGAGCTCAGGGATTATGTCTCAGGTGGGCCGAGAAGAAGAACATTATCAGGAGAAAGCAGACCGTGAAAATATGTTCCTGACACCTTCCACAGACCACAGCCCTTTCTTGAAAGGAAACCAAAATAGCTTACAACACAAGGATTCAGGCTCTTCAGCTGCTTGTCCTTCTTTAATGCCTTTGCTACAACTCTCCTACTCTGATGAGCAACAGTTGTGA*CAGTGGCACCAAAGGTCATTTGTGGTTGTTTTTGTTTGTTTGTTTCTTAAATCCTACTATCTCCTGGCCTGGACCTCAGAAGGAGCTTTTTGCTTATCTATAATTTTTCACTGCCAATTTTTGATATCCTCTCTCCTAGAGTTACTGTTAAAAGGTTGGTTCGTAAAGTCCACACCCCGATGCTCAGAAGTGTCTTGCCAGCAACATTCCTGCTAGCATACAGGAGTGATTTCCTAAACCAGTTTCATTCTAGTCTGAATAGGGACAAACAAATCTTGAGGAAGCCCAAGTGCGTACCTTTATTTTTGCCCCCACCACCCTCTTTCTGTACTTCAATTTTTGTTTGTTTTTTGTTTTTTTGTCCCTGTCATAAAATATTTTGGTGCTTCAAAACTTGTACCTTCATTGTACATCCTTTTCTTTTCTCCCCTTGGGTCTTATTATAAAAGAAGACAATGTACGTTGTAATTACCAAAAAGAATAGGGAAAAACAAGAATTTCATGACTCTACCTGTGGTCTATCTTTAATTTCATTTCTTTTGTTAAAAATAAAACAATGAGTATGTTTGGATAC
106430: TCAGTCGGCTCTTAGAGTAGTAACCGCCAGAAAGGAGTCGGAAGAGGTCTCACGAGGCTGTCATCACCGCC^ATGCCCAAGAATAAAG|GTAAAGGAGGTAAAAACAGGCGCAGGGGTAAAAATGAGAATGAATCTGAAAAAAGAGAGTTGGTGTTTAAAGAGGATGGACAAG|AGTATGCTCAGGTAATCAAAATGTTGGGAAATGGACGATTGGAAGCATTGTGTTTTGATGGTGTAAAGAGGTTATGCCATATCAGAGGGAAATTGAGAAAAAAG|GATAACAAAGCTGATGTAATTTTAAAGTACAATGCAGATGAAGCTAGAAGCCTGAAGGCATATGGCGAGCTTCCAGAACATG|CTAAAATCAATGAAACAGACACATTTGGTCCTGGAGATGATGATGAAATCCAGTTTGACGATATTGGAGATGATGATGAAGACATTGATGAT|ATCTAA*ATTGAACCAAGTGTTTTTACATGACAAGTTCTCTGAGGATGGTTCTACAGTTGGGATTTTGGCCATCATCAACCAAGAAGAGAAATTCATTTAGTGTGTAGTTTCTGAAAGCAAACTGATTTATTTTCATTGTTTTAAAGTATTTATTTCTTTAAAAGCTGAGGACACTGAATTACCTTAAGTTAAATGTTAATACTTTATTGTTTTGATGTAATGGAACTTAAGGATAAAAGACCATAATATTTGCTGTTAAAATAAATAAACGAGTGCCTTTCCTACTGTGA
106431: GGCGTCCGGTCCCAGCCTCCTCTGGGAGCGGGCAGTTGGCGACCCTGCACTGACCCGCGTCCCTCCGTCCCGAGCCCGCGCGCCCTCAGAGGGTGCCCGGACAG|ACTGAAGCC^ATGGCGATTCTTTTTGCTGTTGTTGCCAGGGGGACCACTATCCTTGCCAAACATGCTTGGTGTGGAGGAAACTTCCTGGAGGTGACAGAGCAGATTCTGGCTAAGATACCTTCTGAAAATAACAAACTAACGTACTCACATGGCAA|TTATTTGTTTCATTACATCTGCCAAGACAGGATTGTATATCTTTGTATCACTGATGAT|GATTTTGAACGTTCCCGAGCCTTTAATTTTCTGAATGAGATAAAGAAGAGGTTCCAGACTACTTACGGTTCAAGAGCACAGACAGCACTTCCATATGCCATGAATAGCGAGTTCTCAAGTGTCTTAGCTGCACAGCTG|AAGCATCACTCTGAGAATAAGGGCCTAGACAAAGTGATGGAGACTCAAGCCCAAGTGGATGAACTGAAAGGAATCATGGTCAGAAACATAG|TCTGTCACCTTCAAAACTACCAGCAGAAATCTTGCTCGAGCCATGTGTATGAAGAACCTCAAGCTCACTATTATCATCATCATCGTATCAATT|GTGTTCATCTATATCATTGTTTCACCTCTCTGTGGTGGATTTACATGGCCAAGCTGTGTGAAGAAATAGGAAAGAAGAAGTTACCATTAACCAAGGATATGAGAGAACAAGGAGTTAAAAGCAATCCATGTGACTCAAGCCTTTCACATACTGACAGATGGTATCTGCCAGTCTCTTCAACCCTCTTCTCACTTTTTAAAATCTTGTTCCATGCCTCCAGGTTTATCTTTGTCTTATCTACCAGTTTATTCCTGTGA*ACTTCAGATTGAACCATTCATTGCAGCAGTAGCCTTAAAAAGGCTTTTGTTTATTTCTTTGGTTTGTTAACTAGTGTCATCTATTTAGAGAAACATTTTTGTTTTTAATTGCTCAAAGCTGTCGCCGCTAGTCTTATGAGCTATCTACTAAAACTATGGAGAAACTTTGTATGTGCACACAAAAGTATTCAAGAGACAGTATTGCTAACATCTCATCTTAATGTCTTTTGTTATTGAGAAGTTTTAGGTGCTTCAAAACAATATAAATGGATAATAGTTGTTATTTGGGGAATTGTAATGATGTTGGTGCTGCTTCCTTCTAAGAGCTCAGACAAGTAAAGTATGAAACATTCTTATTTCAGTTAGATGGGGAACATTTTGCTAGCCCATTAGAAGCACACAGAATTATCCTTGTCCTCCTAATATTGACTTTCAGGAATAAAGTTCAGTGTGCTGATCATTCACAATACAGTGGATAGCTTGATATCTTCTGTTTTCCCATTGCAGTTGATTTGAGAAGATGAAGGTTTAAATATTGTTGAAAGTTGCAGTTTTTTAAATGTGTTCCTTTTTCTTCTGTGAATATTTAGGGCAATCGTGTCGCTAATAGAATATGTAGTAGAGGGGGTGGGGAGGTAAATTCCTCTGACTTGCCAAAGAAAAAGAAGGGAACCACAGTGGATATGCTAGCATTTTAGCTGTGCAAAGGGAGGTAGTGTGGGAAAAGTGTTTCCATTCTGGGAAAAGCCCAAACCGAATACGGTCAGCAGTCAACTCCAGGGTTTGGGCTTGATTCCTGTTGAATAATAGTTTTGAGCATTCTTTGTGGTTAAATAAATTCTTAAATCTGCCTAGTTTTGATGAATTCTTTTGTGAAACTTGAAAGAGAATAGACAGTATGACATATAGAATTAATACAAAACAGTTTAACAACCATTTAACTGCAGTGTAAGAAAATTGGACTGTAATCATATCGCTACTGGCATCTGTTATCTAGTATGCATTTCTGGTGTGTATCTGAAAGGAAGACATTTTCTACCCTAGATCCAATTGCATTTATTTATCAATAAGTGCCATTAAATTGAAATTATATTACATTTTACACTTTCTCAATGAATGAACAAATTAGTCTGTAGAATCTAGCCACCTGTTTAGCCTAGTCATGTGCCTTGAACATATATGTGTCCCATAATCTGGCTCATGGTACCTGTTCTTCTATCCAAACCTTTCAATTCATGCTACCTGATTCATTTATTTGACATAGATCTTAGGCCCACTTGAACTCTTTTCTTGTTTATCTAGCATAGCACAAACGTTTTTCCAGTCTTCTTTATCAACACTAATGCCTCTTAATTGCATCAGTATTTCCTATTGGAAAATACATCTGTTCCAGAAAAACATTTGGCATTCCTGAATAATTTCCAAATGTTTTTAATCCAAAGAAAAAGGTTTAAAGCTTATTTCCCTTTCTTATACACACCTGAATAAAATTGATGTGCATGTTTTAGGGATCAATTACCTAACTGTTCCTTGGTCTATTTATGTATAAGAATGCTTTTTAAAGCACATGTCTCATTTTAAATGACGCACAAACTGAAGATGTTAATAAAATTTAAGAGTAATACAA
106432: GGCGTCCGGTCCCAGCCTCCTCTGGGAGCGGGCAGTTGGCGACCCTGCACTGACCCGCGTCCCTCCGTCCCGAGCCCGCGCGCCCTCAGAGGGTGCCCGGACAG|ACTGAAGCCATGGCGATTCTTTTTGCTGTTGTTGCCAGGGGGACCACTATCCTTGCCAAACATGCTTGGTGTGGAGGAAACTTCCTGGAGGTGACAGAGCAGATTCTGGCTAAGATACCTTCTGAAAATAACAAACTAACGTACTCACATGGCAA|TTATTTGTTTCATTACATCTGCCAAGACAGGATTGTATATCTTTGTATCACTGATGATGTAA|GATTTTGAACGTTCCCGAGCCTTTAATTTTCTGAATGAGATAAAGAAGAGGTTCCAGACTACTTACGGTTCAAGAGCACAGACAGCACTTCCATATGCC^ATGAATAGCGAGTTCTCAAGTGTCTTAGCTGCACAGCTG|AAGCATCACTCTGAGAATAAGGGCCTAGACAAAGTGATGGAGACTCAAGCCCAAGTGGATGAACTGAAAGGAATCATGGTCAGAAACATAG|ATCTGGTAGCTCAGCGAGGAGAAAGATTGGAATTATTGATTGACAAAACAGAAAATCTTGTGGATTCT|TCTGTCACCTTCAAAACTACCAGCAGAAATCTTGCTCGAGCCATGTGTATGAAGAACCTCAAGCTCACTATTATCATCATCATCGTATCAATT|GTGTTCATCTATATCATTGTTTCACCTCTCTGTGGTGGATTTACATGGCCAAGCTGTGTGAAGAAATAG*GAAAGAAGAAGTTACCATTAACCAAGGATATGAGAGAACAAGGAGTTAAAAGCAATCCATGTGACTCAAGCCTTTCACATACTGACAGATGGTATCTGCCAGTCTCTTCAACCCTCTTCTCACTTTTTAAAATCTTGTTCCATGCCTCCAGGTTTATCTTTGTCTTATCTACCAGTTTATTCCTGTGAACTTCAGATTGAACCATTCATTGCAGCAGTAGCCTTAAAAAGGCTTTTGTTTATTTCTTTGGTTTGTTAACTAGTGTCATCTATTTAGAGAAACATTTTTGTTTTTAATTGCTCAAAGCTGTCGCCGCTAGTCTTATGAGCTATCTACTAAAACTATGGAGAAACTTTGTATGTGCACACAAAAGTATTCAAGAGACAGTATTGCTAACATCTCATCTTAATGTCTTTTGTTATTGAGAAGTTTTAGGTGCTTCAAAACAATATAAATGGATAATAGTTGTTATTTGGGGAATTGTAATGATGTTGGTGCTGCTTCCTTCTAAGAGCTCAGACAAGTAAAGTATGAAACATTCTTATTTCAGTTAGATGGGGAACATTTTGCTAGCCCATTAGAAGCACACAGAATTATCCTTGTCCTCCTAATATTGACTTTCAGGAATAAAGTTCAGTGTGCTGATCATTCACAATACAGTGGATAGCTTGATATCTTCTGTTTTCCCATTGCAGTTGATTTGAGAAGATGAAGGTTTAAATATTGTTGAAAGTTGCAGTTTTTTAAATGTGTTCCTTTTTCTTCTGTGAATATTTAGGGCAATCGTGTCGCTAATAGAATATGTAGTAGAGGGGGTGGGGAGGTAAATTCCTCTGACTTGCCAAAGAAAAAGAAGGGAACCACAGTGGATATGCTAGCATTTTAGCTGTGCAAAGGGAGGTAGTGTGGGAAAAGTGTTTCCATTCTGGGAAAAGCCCAAACCGAATACGGTCAGCAGTCAACTCCAGGGTTTGGGCTTGATTCCTGTTGAATAATAGTTTTGAGCATTCTTTGTGGTTAAATAAATTCTTAAATCTGCCTAGTTTTGATGAATTCTTTTGTGAAACTTGAAAGAGAATAGACAGTATGACATATAGAATTAATACAAAACAGTTTAACAACCATTTAACTGCAGTGTAAGAAAATTGGACTGTAATCATATCGCTACTGGCATCTGTTATCTAGTATGCATTTCTGGTGTGTATCTGAAAGGAAGACATTTTCTACCCTAGATCCAATTGCATTTATTTATCAATAAGTGCCATTAAATTGAAATTATATTACATTTTACACTTTCTCAATGAATGAACAAATTAGTCTGTAGAATCTAGCCACCTGTTTAGCCTAGTCATGTGCCTTGAACATATATGTGTCCCATAATCTGGCTCATGGTACCTGTTCTTCTATCCAAACCTTTCAATTCATGCTACCTGATTCATTTATTTGACATAGATCTTAGGCCCACTTGAACTCTTTTCTTGTTTATCTAGCATAGCACAAACGTTTTTCCAGTCTTCTTTATCAACACTAATGCCTCTTAATTGCATCAGTATTTCCTATTGGAAAATACATCTGTTCCAGAAAAACATTTGGCATTCCTGAATAATTTCCAAATGTTTTTAATCCAAAGAAAAAGGTTTAAAGCTTATTTCCCTTTCTTATACACACCTGAATAAAATTGATGTGCATGTTTTAGGGATCAATTACCTAACTGTTCCTTGGTCTATTTATGTATAAGAATGCTTTTTAAAGCACATGTCTCATTTTAAATGACGCACAAACTGAAGATGTTAATAAAATTTAAGAGTAATACAA
SeqNoBars
1: GCTTCGGGTTGGTGTC^ATGGCAGCTGCGGGGAGCCGCAAGAG|GCGCCTGGCGGAGCTGACGGTGGACGAGTTCCTAGCTTCGGGCTTTGACTCCGAGTCCGAATCCGAGTCCGAAAATTCTCCACAAGCGGAGACACGGGAAGCACGCGAGGCTGCCCGGAGTCCGGATAAGCCGGGCGGGAGCCCCTCGGCCAG|CCGGCGTAAAGGCCGTGCCTCTGAGCACAAAGACCAGCTCTCTCGGCTGAAGGACAGAGACCCCGAGTTCTACAAGTTCCTGCAGGAGAATGACCAGAGCCTGCTAAACTTCAGCGACTCGGACAGCTCTGAGGAGGAAGAGGGGCCGTTCCACTCCCTGCCAGATGTGCTGGAG|GAAGCCAGTGAGGAGGAGGATGGAGCGGAGGAAGGAGAAGATGGGGACAGAGTCCCCAGAGGGCTGAAGGGGAAGAAGAATTCTGTTCCTGTGACCGTCGCCATGGTTGAGAGATGGAAGCAGGCAGCAAAG|CAACGCCTCACTCCAAAGCTGTTCCATGAAGTGGTACAGGCGTTCCGAGCAGCTGTGGCCACCACCCGAGGGGACCAGGAAAGTGCTGAGGCCAACAAATTCCAGGTCACGGACAGTGCTG|CATTCAATGCTCTGGTTACCTTCTGCATCAGAGACCTCATTGGCTGTCTCCAGAAGCTGCTGTTTGGAAAGGTGGCAAAGGATAGCAGCAG|ATGTTCCAGCAGGTCGACTTCAACAGGAAGCCAGGGCGCATGA*GCTCCAAGCCCATCAACTTCTCCGTGATCCTGAAGCTGTCCAATGTCAACCTGCAGGAGAAGGCGTACCGG|GACGGCCTGGTGGAGCAGCTGTACGACCTCACCCTGGAGTACCTGCACAGCCAGGCACACTGCATCGGCTTCCCGGAGCTGGTGCTGCCTGTGGTCCTGCAG|CTGAAGTCGTTCCTCCGGGAGTGCAAGGTGGCCAACTACTGCCGGCAGGTGCAGCAGCTGCTTGGGAAGGTTCAGGAGAACTCGGCATACATCTGCAGCCGCCGCCAGAGGGTTTCCTTCGGCGTCTCTGAGCAGCAGGCAGTG|GAAGCCTGGGAGAAGCTGACCCGGGAAGAGGGGACACCCCTGACCTTGTACTACAGCCACTGGCGCAAGCTGCGTGACCGGGAGATCCAGCTGGAGATCAGTGGCAAAGAGCGG|CTGGAAGACCTGAACTTCCCTGAGATCAAACGAAGGAAGATGGCTGACAGGAAGGATGAGGACAGGAAGCAATTTAAAGACCTCTTTGACCTGAACAGCTCTGAAGAGGACGACACCGAGGGATTCTCGGAGAGAG|GGATACTGAGGCCCCTGAGCACTCGGCATGGGGTGGAAGACGATGAAGAGGACGAGGAGGAGGGCGAGGAGGACAGCAGCAACTCGGAGGGTGAATGGTCTTGGGGTGAGAGGGTGTGGCCCTGTGAGCCCATCTGGCGGGAGGGCAGAGCCACGTGGGCGGGGGGCGTGGGGCTCTGGGCCAGGCTTTTCCCTCCCTGGGAAGGCCAGGCCAAATGCTCTGTTCTCTGGCAGCCAGCAACAGGGATAAATTAATTAGTGCCGTGATTAATTAGTGATGAGTAACCTCTAAGGCTGGCTTCTTCCTGATAAAGCAAAATTTATGTAGCCTCCATCTCTCCCCGCAGATGGAGACCCAGACGCAGAGGCGGGGCTGGCCCCTGGGGAGCTGCAGCAGCTGGCCCAGGGGCCGGAGGACGAGCTGGAGGATCTGCAGCTCTCAGAGGACGACTGAGGCAGCCCATCTGGGGGGCCTGTAGGGGCTGCCGGGCTGGTGGCCAGTGTTTCCACCTCCCTGGCAGTCAGGCCTAGAGGCTGGCGTCTGTGCAGTTGGGGGAGGCAGTAGACACGGGACAGGCTTTATTATTTATTTTTCAGCATGAAAGACCAAACGTATCGAGAGCTGGGCTGGGCTGGGCTGGTGTGGCTGCTGAAGCCCCACAGCTGTGGGCTGCTGAAGTCAGCTCCGCGGGGGAGCTGACCCTGACGTCAGCAGACCGAGACCAGTCCCAGTTCCAGGGGGAGGCCTGCAGGCCCCTGGCCCCTTCCACCACCTCTGCCCTCCGTCTGCAGACCTCGTCCATCTGCACCAGGCTCTGCCTTCACTCCCCCAAGTCTTTGAAAATTTGTTCCTTTCCTTTGAAGTCACATTTTCTTTTAAAATTTTTTGTTTTGCATCCGAAACCGAAAGAAATAAAGCGGTGGGAGGCAGGGCCATTGTGTT
2: GCTTCGGGTTGGTGTC^ATGGCAGCTGCGGGGAGCCGCAAGAG|GCGCCTGGCGGAGCTGACGGTGGACGAGTTCCTAGCTTCGGGCTTTGACTCCGAGTCCGAATCCGAGTCCGAAAATTCTCCACAAGCGGAGACACGGGAAGCACGCGAGGCTGCCCGGAGTCCGGATAAGCCGGGCGGGAGCCCCTCGGCCAG|CCGGCGTAAAGGCCGTGCCTCTGAGCACAAAGACCAGCTCTCTCGGCTGAAGGACAGAGACCCCGAGTTCTACAAGTTCCTGCAGGAGAATGACCAGAGCCTGCTAAACTTCAGCGACTCGGACAGCTCTGAGGAGGAAGAGGGGCCGTTCCACTCCCTGCCAGATGTGCTGGAG|GAAGCCAGTGAGGAGGAGGATGGAGCGGAGGAAGGAGAAGATGGGGACAGAGTCCCCAGAGGGCTGAAGGGGAAGAAGAATTCTGTTCCTGTGACCGTCGCCATGGTTGAGAGATGGAAGCAGGCAGCAAAG|CAACGCCTCACTCCAAAGCTGTTCCATGAAGTGGTACAGGCGTTCCGAGCAGCTGTGGCCACCACCCGAGGGGACCAGGAAAGTGCTGAGGCCAACAAATTCCAGGTCACGGACAGTGCTG|CATTCAATGCTCTGGTTACCTTCTGCATCAGAGACCTCATTGGCTGTCTCCAGAAGCTGCTGTTTGGAAAGGTGGCAAAGGATAGCAGCAG|GATGCTGCAGCCGTCCAGCAGCCCGCTCTGGGGGAAGCTTCGTGTGGACATCAAGGCTTACCTGGGCTCGGCCATACAG|CTGGTGTCCTGTCTGTCGGAGACGACGGTGTTGGCGGCCGTGCTGCGGCACATCAGCGTGCTGGTGCCCTGCTTCCTGACCTTCCCCAAGCAGTGCCGCATGCTGCTCAAG|AGAATGGTGATCGTATGGAGCACTGGGGAAGAGTCTCTGCGGGTGCTGGCTTTCCTGGTCCTCAGCAGAGTCTGCCGGCACAAGAAGGACACTTTCCTTGGCCCCGTCCTCAAG|TTTCATGCAGTGGACCTTGACGGAGCTGCTGGCCCTGGAGCCGGGTGTGGCCTACCAGCACGCCTTCCTCTACATCCGCCAGCTCGCCATACACCTGCGCAACGCCATGACCACTCGCAAGAAG|GAAACATACCAGTCTGTGTACAACTGGCAGTATGTGCACTGCCTCTTCCTGTGGTGCCGGGTCCTGAGCACTGCGGGCCCCAGCGAAGCCCTCCAGCCCTTGGTCTACCCCCTTGCCCAAGTCATCATTGGCTGTATCAA|GCTCATCCCCACTGCCCGCTTCTACCCGCTGCGAATGCACTGCATCCGTGCCCTGACGCTGCTCTCGGGGAGCTCGGGGGCCTTCATCCCGGTGCTGCCTTTCATCCTGGAG|ATGTTCCAGCAGGTCGACTTCAACAGGAAGCCAGGGCGCATGAGCTCCAAGCCCATCAACTTCTCCGTGATCCTGAAGCTGTCCAATGTCAACCTGCAGGAGAAGGCGTACCGG|GACGGCCTGGTGGAGCAGCTGTACGACCTCACCCTGGAGTACCTGCACAGCCAGGCACACTGCATCGGCTTCCCGGAGCTGGTGCTGCCTGTGGTCCTGCAG|CTGAAGTCGTTCCTCCGGGAGTGCAAGGTGGCCAACTACTGCCGGCAGGTGCAGCAGCTGCTTGGGAAGGTTCAGGAGAACTCGGCATACATCTGCAGCCGCCGCCAGAGGGTTTCCTTCGGCGTCTCTGA*GCAGCAGGCAGTG|GAAGCCTGGGAGAAGCTGACCCGGGAAGAGGGGACACCCCTGACCTTGTACTACAGCCACTGGCGCAAGCTGCGTGACCGGGAGATCCAGCTGGAGATCAGTGGCAAAGAGCGG|CTGGAAGACCTGAACTTCCCTGAGATCAAACGAAGGAAGATGGCTGACAGGAAGGATGAGGACAGGAAGCAATTTAAAGACCTCTTTGACCTGAACAGCTCTGAAGAGGACGACACCGAGGGATTCTCGGAGAGAG|GGATACTGAGGCCCCTGAGCACTCGGCATGGGGTGGAAGACGATGAAGAGGACGAGGAGGAGGGCGAGGAGGACAGCAGCAACTCGGAGGGTGAATGGTCTTGGGGTGAGAGGGTGTGGCCCTGTGAGCCCATCTGGCGGGAGGGCAGAGCCACGTGGGCGGGGGGCGTGGGGCTCTGGGCCAGGCTTTTCCCTCCCTGGGAAGGCCAGGCCAAATGCTCTGTTCTCTGGCAGCCAGCAACAGGGATAAATTAATTAGTGCCGTGATTAATTAGTGATGAGTAACCTCTAAGGCTGGCTTCTTCCTGATAAAGCAAAATTTATGTAGCCTCCATCTCTCCCCGCAGATGGAGACCCAGACGCAGAGGCGGGGCTGGCCCCTGGGGAGCTGCAGCAGCTGGCCCAGGGGCCGGAGGACGAGCTGGAGGATCTGCAGCTCTCAGAGGACGACTGAGGCAGCCCATCTGGGGGGCCTGTAGGGGCTGCCGGGCTGGTGGCCAGTGTTTCCACCTCCCTGGCAGTCAGGCCTAGAGGCTGGCGTCTGTGCAGTTGGGGGAGGCAGTAGACACGGGACAGGCTTTATTATTTATTTTTCAGCATGAAAGACCAAACGTATCGAGAGCTGGGCTGGGCTGGGCTGGTGTGGCTGCTGAAGCCCCACAGCTGTGGGCTGCTGAAGTCAGCTCCGCGGGGGAGCTGACCCTGACGTCAGCAGACCGAGACCAGTCCCAGTTCCAGGGGGAGGCCTGCAGGCCCCTGGCCCCTTCCACCACCTCTGCCCTCCGTCTGCAGACCTCGTCCATCTGCACCAGGCTCTGCCTTCACTCCCCCAAGTCTTTGAAAATTTGTTCCTTTCCTTTGAAGTCACATTTTCTTTTAAAATTTTTTGTTTTGCATCCGAAACCGAAAGAAATAAAGCGGTGGGAGGCAGGGCCATTGTG
3: GCTTCGGGTTGGTGTC^ATGGCAGCTGCGGGGAGCCGCAAGAG|GCGCCTGGCGGAGCTGACGGTGGACGAGTTCCTAGCTTCGGGCTTTGACTCCGAGTCCGAATCCGAGTCCGAAAATTCTCCACAAGCGGAGACACGGGAAGCACGCGAGGCTGCCCGGAGTCCGGATAAGCCGGGCGGGAGCCCCTCGGCCAG|CCGGCGTAAAGGCCGTGCCTCTGAGCACAAAGACCAGCTCTCTCGGCTGAAGGACAGAGACCCCGAGTTCTACAAGTTCCTGCAGGAGAATGACCAGAGCCTGCTAAACTTCAGCGACTCGGACAGCTCTGAGGAGGAAGAGGGGCCGTTCCACTCCCTGCCAGATGTGCTGGAG|GAAGCCAGTGAGGAGGAGGATGGAGCGGAGGAAGGAGAAGATGGGGACAGAGTCCCCAGAGGGCTGAAGGGGAAGAAGAATTCTGTTCCTGTGACCGTCGCCATGGTTGAGAGATGGAAGCAGGCAGCAAAG|CAACGCCTCACTCCAAAGCTGTTCCATGAAGTGGTACAGGCGTTCCGAGCAGCTGTGGCCACCACCCGAGGGGACCAGGAAAGTGCTGAGGCCAACAAATTCCAGGTCACGGACAGTGCTG|CATTCAATGCTCTGGTTACCTTCTGCATCAGAGACCTCATTGGCTGTCTCCAGAAGCTGCTGTTTGGAAAGGTGGCAAAGGATAGCAGCAG|GATGCTGCAGCCGTCCAGCAGCCCGCTCTGGGGGAAGCTTCGTGTGGACATCAAGGCTTACCTGGGCTCGGCCATACAG|CTGGTGTCCTGTCTGTCGGAGACGACGGTGTTGGCGGCCGTGCTGCGGCACATCAGCGTGCTGGTGCCCTGCTTCCTGACCTTCCCCAAGCAGTGCCGCATGCTGCTCAAG|AGAATGGTGATCGTATGGAGCACTGGGGAAGAGTCTCTGCGGGTGCTGGCTTTCCTGGTCCTCAGCAGAGTCTGCCGGCACAAGAAGGACACTTTCCTTGGCCCCGTCCTCAAG|CAAATGTACATCACGTATGTGAGGAACTGCAAGTTCACCTCGCCTGGTGCCCTCCCCTTCATCAGTTTCATGCAGTGGACCTTGACGGAGCTGCTGGCCCTGGAGCCGGGTGTGGCCTACCAGCACGCCTTCCTCTACATCCGCCAGCTCGCCATACACCTGCGCAACGCCATGACCACTCGCAAGAAG|GAAACATACCAGTCTGTGTACAACTGGCAGTATGTGCACTGCCTCTTCCTGTGGTGCCGGGTCCTGAGCACTGCGGGCCCCAGCGAAGCCCTCCAGCCCTTGGTCTACCCCCTTGCCCAAGTCATCATTGGCTGTATCAA|GCTCATCCCCACTGCCCGCTTCTACCCGCTGCGAATGCACTGCATCCGTGCCCTGACGCTGCTCTCGGGGAGCTCGGGGGCCTTCATCCCGGTGCTGCCTTTCATCCTGGAG|ATGTTCCAGCAGGTCGACTTCAACAGGAAGCCAGGGCGCATGAGCTCCAAGCCCATCAACTTCTCCGTGATCCTGAAGCTGTCCAATGTCAACCTGCAGGAGAAGGCGTACCGG|GACGGCCTGGTGGAGCAGCTGTACGACCTCACCCTGGAGTACCTGCACAGCCAGGCACACTGCATCGGCTTCCCGGAGCTGGTGCTGCCTGTGGTCCTGCAG|CTGAAGTCGTTCCTCCGGGAGTGCAAGGTGGCCAACTACTGCCGGCAGGTGCAGCAGCTGCTTGGGAAGGTTCAGGAGAACTCGGCATACATCTGCAGCCGCCGCCAGAGGGTTTCCTTCGGCGTCTCTGAGCAGCAGGCAGTG|GAAGCCTGGGAGAAGCTGACCCGGGAAGAGGGGACACCCCTGACCTTGTACTACAGCCACTGGCGCAAGCTGCGTGACCGGGAGATCCAGCTGGAGATCAGTGGCAAAGAGCGG|CTGGAAGACCTGAACTTCCCTGAGATCAAACGAAGGAAGATGGCTGACAGGAAGGATGAGGACAGGAAGCAATTTAAAGACCTCTTTGACCTGAACAGCTCTGAAGAGGACGACACCGAGGGATTCTCGGAGAGAG|GGATACTGAGGCCCCTGAGCACTCGGCATGGGGTGGAAGACGATGAAGAGGACGAGGAGGAGGGCGAGGAGGACAGCAGCAACTCGGAGG|ATGGAGACCCAGACGCAGAGGCGGGGCTGGCCCCTGGGGAGCTGCAGCAGCTGGCCCAGGGGCCGGAGGACGAGCTGGAGGATCTGCAGCTCTCAGAGGACGACTGA*GGCAGCCCATCTGGGGGGCCTGTAGGGGCTGCCGGGCTGGTGGCCAGTGTTTCCACCTCCCTGGCAGTCAGGCCTAGAGGCTGGCGTCTGTGCAGTTGGGGGAGGCAGTAGACACGGGACAGGCTTTATTATTTATTTTTCAGCATGAAAGACCAAACGTATCGAGAGCTGGGCTGGGCTGGGCTGGTGTGGCTGCTGAAGCCCCACAGCTGTGGGCTGCTGAAGTCAGCTCCGCGGGGGAGCTGACCCTGACGTCAGCAGACCGAGACCAGTCCCAGTTCCAGGGGGAGGCCTGCAGGCCCCTGGCCCCTTCCACCACCTCTGCCCTCCGTCTGCAGACCTCGTCCATCTGCACCAGGCTCTGCCTTCACTCCCCCAAGTCTTTGAAAATTTGTTCCTTTCCTTTGAAGTCACATTTTCTTTTAAAATTTTTTGTTTTGCATCCGAAACCGAAAGAAATAAAGCGGTGGGAGGCAGGGCCAT
4: GCTTCGGGTTGGTGTC^ATGGCAGCTGCGGGGAGCCGCAAGAG|GCGCCTGGCGGAGCTGACGGTGGACGAGTTCCTAGCTTCGGGCTTTGACTCCGAGTCCGAATCCGAGTCCGAAAATTCTCCACAAGCGGAGACACGGGAAGCACGCGAGGCTGCCCGGAGTCCGGATAAGCCGGGCGGGAGCCCCTCGGCCAG|CCGGCGTAAAGGCCGTGCCTCTGAGCACAAAGACCAGCTCTCTCGGCTGAAGGACAGAGACCCCGAGTTCTACAAGTTCCTGCAGGAGAATGACCAGAGCCTGCTAAACTTCAGCGACTCGGACAGCTCTGAGGAGGAAGAGGGGCCGTTCCACTCCCTGCCAGATGTGCTGGAG|GAAGCCAGTGAGGAGGAGGATGGAGCGGAGGAAGGAGAAGATGGGGACAGAGTCCCCAGAGGGCTGAAGGGGAAGAAGAATTCTGTTCCTGTGACCGTCGCCATGGTTGAGAGATGGAAGCAGGCAGCAAAG|CAACGCCTCACTCCAAAGCTGTTCCATGAAGTGGTACAGGCGTTCCGAGCAGCTGTGGCCACCACCCGAGGGGACCAGGAAAGTGCTGAGGCCAACAAATTCCAGGTCACGGACAGTGCTG|CATTCAATGCTCTGGTTACCTTCTGCATCAGAGACCTCATTGGCTGTCTCCAGAAGCTGCTGTTTGGAAAGGTGGCAAAGGATAGCAGCAG|GATGCTGCAGCCGTCCAGCAGCCCGCTCTGGGGGAAGCTTCGTGTGGACATCAAGGCTTACCTGGGCTCGGCCATACAG|CTGGTGTCCTGTCTGTCGGAGACGACGGTGTTGGCGGCCGTGCTGCGGCACATCAGCGTGCTGGTGCCCTGCTTCCTGACCTTCCCCAAGCAGTGCCGCATGCTGCTCAAG|AGAATGGTGATCGTATGGAGCACTGGGGAAGAGTCTCTGCGGGTGCTGGCTTTCCTGGTCCTCAGCAGAGTCTGCCGGCACAAGAAGGACACTTTCCTTGGCCCCGTCCTCAAG|CAAATGTACATCACGTATGTGAGGAACTGCAAGTTCACCTCGCCTGGTGCCCTCCCCTTCATCAGTTTCATGCAGTGGACCTTGACGGAGCTGCTGGCCCTGGAGCCGGGTGTGGCCTACCAGCACGCCTTCCTCTACATCCGCCAGCTCGCCATACACCTGCGCAACGCCATGACCACTCGCAAGAAG|GAAACATACCAGTCTGTGTACAACTGGCAGTATGTGCACTGCCTCTTCCTGTGGTGCCGGGTCCTGAGCACTGCGGGCCCCAGCGAAGCCCTCCAGCCCTTGGTCTACCCCCTTGCCCAAGTCATCATTGGCTGTATCAA|GCTCATCCCCACTGCCCGCTTCTACCCGCTGCGAATGCACTGCATCCGTGCCCTGACGCTGCTCTCGGGGAGCTCGGGGGCCTTCATCCCGGTGCTGCCTTTCATCCTGGAG|CAGGTCGACTTCAACAGGAAGCCAGGGCGCATGAGCTCCAAGCCCATCAACTTCTCCGTGATCCTGAAGCTGTCCAATGTCAACCTGCAGGAGAAGGCGTACCGG|GACGGCCTGGTGGAGCAGCTGTACGACCTCACCCTGGAGTACCTGCACAGCCAGGCACACTGCATCGGCTTCCCGGAGCTGGTGCTGCCTGTGGTCCTGCAG|CTGAAGTCGTTCCTCCGGGAGTGCAAGGTGGCCAACTACTGCCGGCAGGTGCAGCAGCTGCTTGGGAAGGTTCAGGAGAACTCGGCATACATCTGCAGCCGCCGCCAGAGGGTTTCCTTCGGCGTCTCTGAGCAGCAGGCAGTG|GAAGCCTGGGAGAAGCTGACCCGGGAAGAGGGGACACCCCTGACCTTGTACTACAGCCACTGGCGCAAGCTGCGTGACCGGGAGATCCAGCTGGAGATCAGTGGCAAAGAGCGG|CTGGAAGACCTGAACTTCCCTGAGATCAAACGAAGGAAGATGGCTGACAGGAAGGATGAGGACAGGAAGCAATTTAAAGACCTCTTTGACCTGAACAGCTCTGAAGAGGACGACACCGAGGGATTCTCGGAGAGAG|GGATACTGAGGCCCCTGAGCACTCGGCATGGGGTGGAAGACGATGAAGAGGACGAGGAGGAGGGCGAGGAGGACAGCAGCAACTCGGAGG|ATGGAGACCCAGACGCAGAGGCGGGGCTGGCCCCTGGGGAGCTGCAGCAGCTGGCCCAGGGGCCGGAGGACGAGCTGGAGGATCTGCAGCTCTCAGAGGACGACTGA*GGCAGCCCATCTGGGGGGCCTGTAGGGGCTGCCGGGCTGGTGGCCAGTGTTTCCACCTCCCTGGCAGTCAGGCCTAGAGGCTGGCGTCTGTGCAGTTGGGGGAGGCAGTAGACACGGGACAGGCTTTATTATTTATTTTTCAGCATGAAAGACCAAACGTATCGAGAGCTGGGCTGGGCTGGGCTGGTGTGGCTGCTGAAGCCCCACAGCTGTGGGCTGCTGAAGTCAGCTCCGCGGGGGAGCTGACCCTGACGTCAGCAGACCGAGACCAGTCCCAGTTCCAGGGGGAGGCCTGCAGGCCCCTGGCCCCTTCCACCACCTCTGCCCTCCGTCTGCAGACCTCGTCCATCTGCACCAGGCTCTGCCTTCACTCCCCCAAGTCTTTGAAAATTTGTTCCTTTCCTTTGAAGTCACATTTTCTTTTAAAATTTTTTGTTTTGCATCCGAAACCGAAAGAAATAAAGCGGTGGGAGGCAGGGC
5: GGGGTGCACGCTTCGGGTTGGTGTC^ATGGCAGCTGCGGGGAGCCGCAAGAG|GCGCCTGGCGGAGCTGACGGTGGACGAGTTCCTAGCTTCGGGCTTTGACTCCGAGTCCGAATCCGAGTCCGAAAATTCTCCACAAGCGGAGACACGGGAAGCACGCGAGGCTGCCCGGAGTCCGGATAAGCCGGGCGGGAGCCCCTCGGCCAG|CCGGCGTAAAGGCCGTGCCTCTGAGCACAAAGACCAGCTCTCTCGGCTGAAGGACAGAGACCCCGAGTTCTACAAGTTCCTGCAGGAGAATGACCAGAGCCTGCTAAACTTCAGCGACTCGGACAGCTCTGAGGAGGAAGAGGGGCCGTTCCACTCCCTGCCAGATGTGCTGGAG|GAAGCCAGTGAGGAGGAGGATGGAGCGGAGGAAGGAGAAGATGGGGACAGAGTCCCCAGAGGGCTGAAGGGGAAGAAGAATTCTGTTCCTGTGACCGTCGCCATGGTTGAGAGATGGAAGCAGGCAGCAAAG|CAACGCCTCACTCCAAAGCTGTTCCATGAAGTGGTACAGGCGTTCCGAGCAGCTGTGGCCACCACCCGAGGGGACCAGGAAAGTGCTGAGGCCAACAAATTCCAGGTCACGGACAGTGCTG|CATTCAATGCTCTGGTTACCTTCTGCATCAGAGACCTCATTGGCTGTCTCCAGAAGCTGCTGTTTGGAAAGGTGGCAAAGGATAGCAGCAG|GATGCTGCAGCCGTCCAGCAGCCCGCTCTGGGGGAAGCTTCGTGTGGACATCAAGGCTTACCTGGGCTCGGCCATACAG|CTGGTGTCCTGTCTGTCGGAGACGACGGTGTTGGCGGCCGTGCTGCGGCACATCAGCGTGCTGGTGCCCTGCTTCCTGACCTTCCCCAAGCAGTGCCGCATGCTGCTCAAG|AGAATGGTGATCGTATGGAGCACTGGGGAAGAGTCTCTGCGGGTGCTGGCTTTCCTGGTCCTCAGCAGAGTCTGCCGGCACAAGAAGGACACTTTCCTTGGCCCCGTCCTCAAG|CAAATGTACATCACGTATGTGAGGAACTGCAAGTTCACCTCGCCTGGTGCCCTCCCCTTCATCAGTTTCATGCAGTGGACCTTGACGGAGCTGCTGGCCCTGGAGCCGGGTGTGGCCTACCAGCACGCCTTCCTCTACATCCGCCAGCTCGCCATACACCTGCGCAACGCCATGACCACTCGCAAGAAG|GAAACATACCAGTCTGTGTACAACTGGCAGTATGTGCACTGCCTCTTCCTGTGGTGCCGGGTCCTGAGCACTGCGGGCCCCAGCGAAGCCCTCCAGCCCTTGGTCTACCCCCTTGCCCAAGTCATCATTGGCTGTATCAA|GCTCATCCCCACTGCCCGCTTCTACCCGCTGCGAATGCACTGCATCCGTGCCCTGACGCTGCTCTCGGGGAGCTCGGGGGCCTTCATCCCGGTGCTGCCTTTCATCCTGGAG|ATGTTCCAGCAGGTCGACTTCAACAGGAAGCCAGGGCGCATGAGCTCCAAGCCCATCAACTTCTCCGTGATCCTGAAGCTGTCCAATGTCAACCTGCAGGAGAAGGCGTACCGG|GACGGCCTGGTGGAGCAGCTGTACGACCTCACCCTGGAGTACCTGCACAGCCAGGCACACTGCATCGGCTTCCCGGAGCTGGTGCTGCCTGTGGTCCTGCAG|CTGAAGTCGTTCCTCCGGGAGTGCAAGGTGGCCAACTACTGCCGGCAGGTGCAGCAGCTGCTTGGGAAGGTTCAGGAGAACTCGGCATACATCTGCAGCCGCCGCCAGAGGGTTTCCTTCGGCGTCTCTGAGCAGCAGGCAGTG|GAAGCCTGGGAGAAGCTGACCCGGGAAGAGGGGACACCCCTGACCTTGTACTACAGCCACTGGCGCAAGCTGCGTGACCGGGAGATCCAGCTGGAGATCAGTGGCAAAGAGCGG|CTGGAAGACCTGAACTTCCCTGAGATCAAACGAAGGAAGATGGCTGACAGGAAGGATGAGGACAGGAAGCAATTTAAAGACCTCTTTGACCTGAACAGCTCTGAAGAGGACGACACCGAGGGATTCTCGGAGAGAGGTGGGGCCTGCGTGGTGCTCCCAGGGGAAGGGTGGGCCTGGAGGGCTCTGCTGGACTTCCCAGAGCCACGAGGGCCACCTGTACCCATCCTGCAGGGGGCTCACCAGTCTCTGGCCCAGCTGGGGCCAACCTCAGTGTTGCCAGGCTTCTGGTGCCAGCGCCTTCCCTCCTTGAAGTGA*AGGCCTACTGGGATTGGTAACTCTGTCCCCAGGCCTGTGACCTCCCAGTTCCTCCCCAGGGCTCCTCTCCACCTGCTGGAAGTCAGCGGAGGGAAGGGTGTTGGGAGCCTGGCCACCCTCCTGCCCCCACTGTGACTTTGCTGGTGGACCCTGTGGGTGGGAGTCATATGGACTCTGCTTCTTGTTCCTCAGGGATACTGAGGCCCCTGAGCACTCGGCATGGGGTGGAAGACGATGAAGAGGACGAGGAGGAGGGCGAGGAGGACAGCAGCAACTCGGAGGGTGAATGGTCTTGGG|ATGGAGACCCAGACGCAGAGGCGGGGCTGGCCCCTGGGGAGCTGCAGCAGCTGGCCCAGGGGCCGGAGGACGAGCTGGAGGATCTGCAGCTCTCAGAGGACGACTGAGGCAGCCCATCTGGGGGGCCTGTAGGGGCTGCCGGGCTGGTGGCCAGTGTTTCCACCTCCCTGGCAGTCAGGCCTAGAGGCTGGCGTCTGTGCAGTTGGGGGAGGCAGTAGACACGGGACAGGCTTTATTATTTATTTTTCAGCATGAAAGACCAAACGTATCGAGAGCTGGGCTGGGCTGGGCTGGTGTGGCTGCTGAAGCCCCACAGCTGTGGGCTGCTGAAGTCAGCTCCGCGGGGGAGCTGACCCTGACGTCAGCAGACCGAGACCAGTCCCAGTTCCAGGGGGAGGCCTGCAGGCCCCTGGCCCCTTCCACCACCTCTGCCCTCCGTCTGCAGACCTCGTCCATCTGCACCAGGCTCTGCCTTCACTCCCCCAAGTCTTTGAAAATTTGTTCCTTTCCTTTGAAGTCACATTTTCTTTTAAAATTTTTTGTTTTGCATCCGAAACCGAAAGAAATAAAGCGGTGGGAGGCAGGG
---
106428: GCAGGGCCCGGAGGTCAAGATGGTGGCTGTAAAACTAGGATCCCTGACGATTG|CTTAGCATTAAGGCCCGAC^ATGGAACCGGGGTGTGACGAGTTCCTGCCGCCACCGGAGTGCCCGGTTTTTGAGCCTAGCTGGGCTGAATTCCAAGACCCGCTTGGCTACATTGCGAAAATAAGGCCCATAGCAGAGAAGTCTGGCATCTGCAAAATCCGCCCACCCGCG|GATTGGCAGCCTCCTTTTGCAGTAGAAGTTGACAATTTCAGATTTACTCCTCGCGTCCAAAGGCTAAATGAACTGGAG|GCCCAAACTAGAGTGAAATTGAACTATTTGGATCAGATTGCAAAATTCTGGGAAATTCAAGGCTCCTCTTTAAAGATTCCCAATGTGGAGCGGAAGATCTTGGACCTCTACAGCCTTAGTAAG|ATTGTGATTGAGGAAGGTGGCTATGAAGCCATCTGCAAGGATCGTCGGTGGGCTCGAGTTGCCCAGCGTCTCCACTACCCACCAGGCAAAAACATTGGCTCCCTGCTACGATCACATTACGAACGCATTATTTACCCCTATGAAATGTTTCAGTCTGGAGCCAACCATGTG|CAATGTAACACACACCCGTTTGACAATGAGGTAAAAGATAAGGAATACAAGCCCCACAGCATCCCCCTTAGACAGTCTGTGCAGCCTTCAAAGTTCAGCAGCTACAGTCGACGGGCAAAAAGGCTACAGCCTGAT|CCAGAGCCTACAGAGGAGGACATTGAGAAGCATCCAGAGCTAAAGAAGTTACAGATATATGGGCCAGGTCCCAAAATGATGGGCTTGGGCCTTATGGCTAAGGATAAGGATAAGACTGTGCATAAGAAAG|TCACATGCCCCCCAACTGTTACGGTGAAGGATGAGCAAAGTGGAGGTGGGAACGTGTCATCAACATTGCTCAAGCAGCACTTGAGCCTAGAGCCCTGCACTAAGACAACCATGCAACTTCGAAAGAATCACAGCAGTGCCCAGTTT|ATTGACTCATATATTTGCCAAGTATGCTCCCGTGGGGATGAAGATGATAAGCTTCTTTTCTGTGATGGCTGTGATGACAATTACCACATCTTCTGCTTGTTACCACCCCTTCCTGAAATCCCCAGAGGCATCTGGAGGTGCCCAAAATGTATCTTGGCG|GAGTGTAAACAGCCTCCTGAAGCTTTTGGATTTGAACAGGCTACCCAGGAGTACAGTTTGCAGAGTTTTGGTGAAATGGCTGATTCCTTCAAGTCCGACTACTTCAACATGCCTGTACAT|ATGGTGCCTACAGAACTTGTAGAGAAGGAATTCTGGAGGCTGGTGAGCAGCATTGAGGAAGACGTGACAGTTGAATATGGAGCTGATATTCATTCCAAAGAATTTGGCAGTGGCTTTCCTGTCAGCAATAGCAAACAAAACTTATCTCCTGAGGAGAAG|GAGTATGCGACCAGTGGTTGGAACCTGAATGTGATGCCAGTGCTAGATCAGTCTGTTCTCTGTCACATCAATGCAGACATCTCAGGCATGAAGGTGCCCTGGCTGTACGTGGGCATGGTTTTCTCAGCATTTTGTTGGCATATTGAGGATCACTGGAGTTACTCTATTAACTATCTGCATTG|GGGTGAGCCGAAGACCTGGTATGGTGTACCCTCCCTGGCAGCAGAGCATTTGGAGGAGGTGATGAAGATGCTGACACCTGAGCTGTTTGATAGCCAGCCTGATCTCCTACACCAGCTTGTCACTCTCATGAATCCCAACACTTTGATGTCCCATGGTGTGCCA|GTTGTCCGCACAAACCAGTGTGCAGGGGAGTTTGTCATCACTTTTCCTCGTGCTTACCACAGTGGTTTTAACCAAGGCTACAATTTTGCTGAAGCTGTCAACTTTTGTACTGCTGACTGG|CTACCTGCTGGACGCCAGTGCATTGAACACTACCGCCGGCTCCGGCGCTATTGTGTCTTCTCCCACGAGGAGCTCATCTGCAAGATGGCTGCCTTCCCAGAGACGTTGGATCTCAATCTAGCAGTAGCTGTGCACAAGGAGATGTTCATTATGGTTCAGGAGGAGCGACGTCTACGAAAGGCCCTTTTGGAGAAG|GGCGTCACGGAGGCTGAGCGAGAGGCTTTTGAGCTGCTCCCAGATGATGAACGCCAGTGCATCAAGTGCAAGACCACGTGCTTCTTGTCAGCCCTGGCCTGCTACGACTGCCCAGATGGCCTTGTATGCCTTTCCCACATCAATGACCTCTGCAAGTGCTCTAGTAGCCGACAGTACCTCCG|GTATCGGTACACCTTGGATGAGCTCCCCACCATGCTGCATAAACTGAAGATTCGGGCTGAGTCTTTTGACACCTGGGCCAACAAAGTGCGAGTGGCCTTGGAGGTGGAGGATGGCCGTAAACGCA|GCTTTGAAGAGCTAAGGGCACTGGAGTCTGAGGCTCGTGAGAGGAGGTTTCCTAATAGTGAGCTGCTTCAGCGACTGAAGAACTGCCTGAGTGAGGTGGAGGCTTGTATTGCTCAAGTCCTGGGGCTGGTCAGTGGTCAGGTGGCCAG|GATGGACACTCCACAGCTGACCTTGACTGAACTCCGGGTCCTTCTTGAGCAGATGGGCAGCCTGCCCTGTGCCATGCATCAGATTGGGGATGTCAAG|GTTCTTTCCTGGAAGTGGCGGAGATATGTGTTCCCATACCATCTCTGTGTGTACAGCATGCAAGGAAATATCCTTCCAGACTGA*AATAATTAAAAACTCTAAACTGGGCCTACATAAGACACTGGCTCTTGGGAATGGGGTGGAGAGGACTGATTGGTTGGTTGGTTGATTTCCCTCCAGACACCAGAGTCTTAGAAAGCTTACTAGATGGATAAGATTGTATTAAAGTGGGTTTGGAAAAAGAAATTTAGGTAATTAAAGGAGAAAAATGTCATTCTAGGTAAACAGAGGGCCTTTGTTATTATCAGATAGATCATGTTTTAGGATGTGGTTGAGAATAAGTATTAAGCAATAGGAAATGCCTATAAGAGAAGATGAGAAGTGGAGCAAATCTAGGTGGTTGAGTATTTATGTGGCTAAAGAATCTGCATTTTATCCTATGTCCTTGCAGGATGTCCTGGAACAGGTGGAGGCCTATCAAGCTGAGGCTCGTGAGGCTCTGGCCACACTGCCCTCTAGTCCAGGGCTATTGCGGTCCCTGTTGGAGAGGGGGCAGCAGCTGGGTGTAGAGGTGCCTGAAGCCCATCAGCTTCAGCAGCAGGTGGAGCAGGCGCAATGGCTAGATGAAGTGAAGCAGGCCCTGGCCCCTTCTGCTCACAGGGGCTCTCTGGTCATCATGCAGGGGCTTTTGGTTATGGGTGCCAAGATAGCCTCCAGCCCTTCTGTGGACAAGGCCCGGGCTGAGCTGCAAGAACTACTGACCATTGCAGAGCGCTGGGAAGAAAAGGCTCATTTCTGCCTGGAGGCCAG|GCAGAAGCATCCACCAGCCACATTGGAAGCCATAATTCGTGAGACAGAAAACATCCCTGTTCACCTGCCTAACATCCAGGCTCTCAAAGAAGCTCTGACTAAGGCACAAGCTTGGATTGCTGATGTGGATGAGATCCAA|AATGGTGACCACTACCCCTGTCTAGATGACTTGGAGGGCCTGGTGGCTGTGGGCCGGGACCTGCCTGTGGGGCTGGAAGAGCTGAGACAGCTAGAGCTGCAGGTATTGACAGCACATTCCTGGAGAGAGAAGGCCTCCAAGACCTTTCTCAAGAAGAATTCTTGCTACACACTGCTTGAG|GTGCTTTGCCCGTGTGCAGACGCTGGCTCAGACAGCACCAAGCGTAGCCGGTGGATGGAGAAGGCGCTGGGGTTGTACCAGTGTGACACAGAGCTGCTGGGGCTGTCTGCACAGGACCTCAGAGACCCAGGCTCTGTG|ATTGTGGCCTTCAAGGAAGGGGAACAGAAGGAGAAGGAGGGTATCCTGCAGCTGCGTCGCACCAACTCAGCCAAGCCCAGTCCACTGGCACCATCCCTCATGGCCTCTTCTCCGACTTCTATCTGTGTGTGTGGGCAGGTGCCAGCTGGGGTGGGAGTTCTGCAGTGTGACCTGTGTCAGGACTGGTTCCATGGGCAGTGTGTGTCAGTGCCCCATCTCCTCACCTCTCCAAAGCCCAGTCTCACTTCATCTCCACTGCTAGCCTGGTGGGAATGGGACACAAAATTCCTGTGTCCACTGTGTATGCGCTCACGACGGCCACGCCTAGAGACAATCCTAGCCTTGCTGGTTGCCCTGCAGAGGCTGCCCGTGCGGCTGCCTGAGGGTGAGGCCCTTCAGTGTCTCACAGAGAGGGCCATTGGCTGGCAAGACCGTGCCAGAAAGGCTCTGGCCTCTGAAGATGTGACTGCTCTGTTGCGACAGCTGGCTGAGCTTCGCCAACAGCTACAGGCCAAACCCAGACCAGAGGAGGCCTCAGTCTACACTTCAGCCACTGCCTGTGACCCTATCAGAGAAGGCAGTGGCAACAATATTTCTAAG|GTCCAAGGGCTGCTGGAGAATGGAGACAGTGTGACCAGTCCTGAGAACATGGCTCCAGGAAAGGGCTCTG|TTGACTGGCCCTGTGTTGGAGCTGCCTGAGGCAATCCGGGCTCCCCTGGAGGAGCTCATGATGGAAGGGGACCTGCTTGAGGTGACCCTGGATGAGAACCACAGCATCTGGCAGCTGCTGCAGGCTGGACAGCCTCCAGACCTGGACAGAATTCGCACACTTCTGGAG|CTGGAAAAATTTGAACATCAAGGGAGTCGGACAAGGAGCCGGGCTCTGGAGAGGCGACGGCGGCGGCAGAAGGTGGATCAGGGTAGAAACGTTGAGAATCTTGTTCAACAGGAGCTTCAGTCAAAAAGGGCTCGGAGCTCAGGGATTATGTCTCAGGTGGGCCGAGAAGAAGAACATTATCAGGAGAAAGCAGACCGTGAAAATATGTTCCTGACACCTTCCACAGACCACAGCCCTTTCTTGAAAGGAAACCAAAATAGCTTACAACACAAGGATTCAGGCTCTTCAGCTGCTTGTCCTTCTTTAATGCCTTTGCTACAACTCTCCTACTCTGATGAGCAACAGTTGTGACAGTGGCACCAAAGGTCATTTGTGGTTGTTTTTGTTTGTTTGTTTCTTAAATCCTACTATCTCCTGGCCTGGACCTCAGAAGGAGCTTTTTGCTTATCTATAATTTTTCACTGCCAATTTTTGATATCCTCTCTCCTAGAGTTACTGTTAAAAGGTTGGTTCGTAAAGTCCACACCCCGATGCTCAGAAGTGTCTTGCCAGCAACATTCCTGCTAGCATACAGGAGTGATTTCCTAAACCAGTTTCATTCTAGTCTGAATAGGGACAAACAAATCTTGAGGAAGCCCAAGTGCGTACCTTTATTTTTGCCCCCACCACCCTCTTTCTGTACTTCAATTTTTGTTTGTTTTTTGTTTTTTTGTCCCTGTCATAAAATATTTTGGTGCTTCAAAACTTGTACCTTCATTGTACATCCTTTTCTTTTCTCCCCTTGGGTCTTATTATAAAAGAAGACAATGTACGTTGTAATTACCAAAAAGAATAGGGAAAAACAAGAATTTCATGACTCTACCTGTGGTCTATCTTTAATTTCATTTCTTTTGTTAAAAATAAAACAATGAGTATGTTTGGATACTATGAA
106429: ACTGCAGGGCCCGGAGGTCAAGATGGTGGCTGTAAAACTAGGATCCCTGACGATTG|CTTAGCATTAAGGCCCGACATGGAACCGGGGTGTGACGAGTTCCTGCCGCCACCGGAGTGCCCGGTTTTTGAGCCTAGCTGGGCTGAATTCCAAGACCCGCTTGGCTACATTGCGAAAATAAGGCCCATAGCAGAGAAGTCTGGCATCTGCAAAATCCGCCCACCCGCG|GATTGGCAGCCTCCTTTTGCAGTAGAAGTTGACAATTTCAGATTTACTCCTCGCGTCCAAAGGCTAAATGAACTGGAG|GCCCAAACTAGAGTGAAATTGAACTATTTGGATCAGATTGCAAAATTCTGGGAAATTCAAGGCTCCTCTTTAAAGATTCCCAATGTGGAGCGGAAGATCTTGGACCTCTACAGCCTTAGTAAG|ATTGTGATTGAGGAAGGTGGCTATGAAGCCATCTGCAAGGATCGTCGGTGGGCTCGAGTTGCCCAGCGTCTCCACTACCCACCAGGCAAAAACATTGGCTCCCTGCTACGATCACATTACGAACGCATTATTTACCCCTATGAAATGTTTCAGTCTGGAGCCAACCATGTG|CAATGTAACACACACCCGTTTGACAATGAGGTAAAAGATAAGGAATACAAGCCCCACAGCATCCCCCTTAGACAGTCTGTGCAGCCTTCAAAGTTCAGCAGCTACAGTCGACGGGCAAAAAGGCTACAGCCTGAT|CCAGAGCCTACAGAGGAGGACATTGAGAAGCATCCAGAGCTAAAGAAGTTACAGATATATGGGCCAGGTCCCAAAATGATGGGCTTGGGCCTTATGGCTAAGGATAAGGATAAGACTGTGCATAAGAAAG|TCACATGCCCCCCAACTGTTACGGTGAAGGATGAGCAAAGTGGAGGTGGGAACGTGTCATCAACATTGCTCAAGCAGCACTTGAGCCTAGAGCCCTGCACTAAGACAACCATGCAACTTCGAAAGAATCACAGCAGTGCCCAGTTT|ATTGACTCATATATTTGCCAAGTATGCTCCCGTGGGGATGAAGATGATAAGCTTCTTTTCTGTGATGGCTGTGATGACAATTACCACATCTTCTGCTTGTTACCACCCCTTCCTGAAATCCCCAGAGGCATCTGGAGGTGCCCAAAATGTATCTTGGCG|GAGTGTAAACAGCCTCCTGAAGCTTTTGGATTTGAACAGGCTACCCAGGAGTACAGTTTGCAGAGTTTTGGTGAAATGGCTGATTCCTTCAAGTCCGACTACTTCAACATGCCTGTACAT|ATGGTGCCTACAGAACTTGTAGAGAAGGAATTCTGGAGGCTGGTGAGCAGCATTGAGGAAGACGTGACAGTTGAATATGGAGCTGATATTCATTCCAAAGAATTTGGCAGTGGCTTTCCTGTCAGCAATAGCAAACAAAACTTATCTCCTGAGGAGAAG|GAGTATGCGACCAGTGGTTGGAACCTGAATGTGATGCCAGTGCTAGATCAGTCTGTTCTCTGTCACATCAATGCAGACATCTCAGGCATGAAGGTGCCCTGGCTGTACGTGGGCATGGTTTTCTCAGCATTTTGTTGGCATATTGAGGATCACTGGAGTTACTCTATTAACTATCTGCATTG|GGGTGAGCCGAAGACCTGGTATGGTGTACCCTCCCTGGCAGCAGAGCATTTGGAGGAGGTGATGAAGATGCTGACACCTGAGCTGTTTGATAGCCAGCCTGATCTCCTACACCAGCTTGTCACTCTCATGAATCCCAACACTTTGATGTCCCATGGTGTGCCA|GTTGTCCGCACAAACCAGTGTGCAGGGGAGTTTGTCATCACTTTTCCTCGTGCTTACCACAGTGGTTTTAACCAAGGCTACAATTTTGCTGAAGCTGTCAACTTTTGTACTGCTGACTGGGTGAGTGAGCATGCAGTGGGCCTGCAGGTAGAAAGTATAAAGAATATGGGTAAGGATTATTGTGGAGAAGCTATGCATTGTGGTCTCCAGATAGCCACACACAATCTTGAACGCACTTGCAGCTACCTGCTGGACGCCAGTGCATTGAACACTACCGCCGGCTCCGGCGCTATTGTGTCTTCTCCCACGAGGAGCTCATCTGCAAG^ATGGCTGCCTTCCCAGAGACGTTGGATCTCAATCTAGCAGTAGCTGTGCACAAGGAGATGTTCATTATGGTTCAGGAGGAGCGACGTCTACGAAAGGCCCTTTTGGAGAAG|GGCGTCACGGAGGCTGAGCGAGAGGCTTTTGAGCTGCTCCCAGATGATGAACGCCAGTGCATCAAGTGCAAGACCACGTGCTTCTTGTCAGCCCTGGCCTGCTACGACTGCCCAGATGGCCTTGTATGCCTTTCCCACATCAATGACCTCTGCAAGTGCTCTAGTAGCCGACAGTACCTCCG|GTATCGGTACACCTTGGATGAGCTCCCCACCATGCTGCATAAACTGAAGATTCGGGCTGAGTCTTTTGACACCTGGGCCAACAAAGTGCGAGTGGCCTTGGAGGTGGAGGATGGCCGTAAACGCA|GCTTTGAAGAGCTAAGGGCACTGGAGTCTGAGGCTCGTGAGAGGAGGTTTCCTAATAGTGAGCTGCTTCAGCGACTGAAGAACTGCCTGAGTGAGGTGGAGGCTTGTATTGCTCAAGTCCTGGGGCTGGTCAGTGGTCAGGTGGCCAG|GATGGACACTCCACAGCTGACCTTGACTGAACTCCGGGTCCTTCTTGAGCAGATGGGCAGCCTGCCCTGTGCCATGCATCAGATTGGGGATGTCAAG|GATGTCCTGGAACAGGTGGAGGCCTATCAAGCTGAGGCTCGTGAGGCTCTGGCCACACTGCCCTCTAGTCCAGGGCTATTGCGGTCCCTGTTGGAGAGGGGGCAGCAGCTGGGTGTAGAGGTGCCTGAAGCCCATCAGCTTCAGCAGCAGGTGGAGCAGGCGCAATGGCTAGATGAAGTGAAGCAGGCCCTGGCCCCTTCTGCTCACAGGGGCTCTCTGGTCATCATGCAGGGGCTTTTGGTTATGGGTGCCAAGATAGCCTCCAGCCCTTCTGTGGACAAGGCCCGGGCTGAGCTGCAAGAACTACTGACCATTGCAGAGCGCTGGGAAGAAAAGGCTCATTTCTGCCTGGAGGCCAG|GCAGAAGCATCCACCAGCCACATTGGAAGCCATAATTCGTGAGACAGAAAACATCCCTGTTCACCTGCCTAACATCCAGGCTCTCAAAGAAGCTCTGACTAAGGCACAAGCTTGGATTGCTGATGTGGATGAGATCCAA|AATGGTGACCACTACCCCTGTCTAGATGACTTGGAGGGCCTGGTGGCTGTGGGCCGGGACCTGCCTGTGGGGCTGGAAGAGCTGAGACAGCTAGAGCTGCAGGTATTGACAGCACATTCCTGGAGAGAGAAGGCCTCCAAGACCTTTCTCAAGAAGAATTCTTGCTACACACTGCTTGAG|GTGCTTTGCCCGTGTGCAGACGCTGGCTCAGACAGCACCAAGCGTAGCCGGTGGATGGAGAAGGCGCTGGGGTTGTACCAGTGTGACACAGAGCTGCTGGGGCTGTCTGCACAGGACCTCAGAGACCCAGGCTCTGTG|ATTGTGGCCTTCAAGGAAGGGGAACAGAAGGAGAAGGAGGGTATCCTGCAGCTGCGTCGCACCAACTCAGCCAAGCCCAGTCCACTGGCACCATCCCTCATGGCCTCTTCTCCGACTTCTATCTGTGTGTGTGGGCAGGTGCCAGCTGGGGTGGGAGTTCTGCAGTGTGACCTGTGTCAGGACTGGTTCCATGGGCAGTGTGTGTCAGTGCCCCATCTCCTCACCTCTCCAAAGCCCAGTCTCACTTCATCTCCACTGCTAGCCTGGTGGGAATGGGACACAAAATTCCTGTGTCCACTGTGTATGCGCTCACGACGGCCACGCCTAGAGACAATCCTAGCCTTGCTGGTTGCCCTGCAGAGGCTGCCCGTGCGGCTGCCTGAGGGTGAGGCCCTTCAGTGTCTCACAGAGAGGGCCATTGGCTGGCAAGACCGTGCCAGAAAGGCTCTGGCCTCTGAAGATGTGACTGCTCTGTTGCGACAGCTGGCTGAGCTTCGCCAACAGCTACAGGCCAAACCCAGACCAGAGGAGGCCTCAGTCTACACTTCAGCCACTGCCTGTGACCCTATCAGAGAAGGCAGTGGCAACAATATTTCTAAG|GTCCAAGGGCTGCTGGAGAATGGAGACAGTGTGACCAGTCCTGAGAACATGGCTCCAGGAAAGGGCTCTG|ACCTGGAGCTACTGTCCTCACTGTTGCCGCAGTTGACTGGCCCTGTGTTGGAGCTGCCTGAGGCAATCCGGGCTCCCCTGGAGGAGCTCATGATGGAAGGGGACCTGCTTGAGGTGACCCTGGATGAGAACCACAGCATCTGGCAGCTGCTGCAGGCTGGACAGCCTCCAGACCTGGACAGAATTCGCACACTTCTGGAG|CTGGAAAAATTTGAACATCAAGGGAGTCGGACAAGGAGCCGGGCTCTGGAGAGGCGACGGCGGCGGCAGAAGGTGGATCAGGGTAGAAACGTTGAGAATCTTGTTCAACAGGAGCTTCAGTCAAAAAGGGCTCGGAGCTCAGGGATTATGTCTCAGGTGGGCCGAGAAGAAGAACATTATCAGGAGAAAGCAGACCGTGAAAATATGTTCCTGACACCTTCCACAGACCACAGCCCTTTCTTGAAAGGAAACCAAAATAGCTTACAACACAAGGATTCAGGCTCTTCAGCTGCTTGTCCTTCTTTAATGCCTTTGCTACAACTCTCCTACTCTGATGAGCAACAGTTGTGA*CAGTGGCACCAAAGGTCATTTGTGGTTGTTTTTGTTTGTTTGTTTCTTAAATCCTACTATCTCCTGGCCTGGACCTCAGAAGGAGCTTTTTGCTTATCTATAATTTTTCACTGCCAATTTTTGATATCCTCTCTCCTAGAGTTACTGTTAAAAGGTTGGTTCGTAAAGTCCACACCCCGATGCTCAGAAGTGTCTTGCCAGCAACATTCCTGCTAGCATACAGGAGTGATTTCCTAAACCAGTTTCATTCTAGTCTGAATAGGGACAAACAAATCTTGAGGAAGCCCAAGTGCGTACCTTTATTTTTGCCCCCACCACCCTCTTTCTGTACTTCAATTTTTGTTTGTTTTTTGTTTTTTTGTCCCTGTCATAAAATATTTTGGTGCTTCAAAACTTGTACCTTCATTGTACATCCTTTTCTTTTCTCCCCTTGGGTCTTATTATAAAAGAAGACAATGTACGTTGTAATTACCAAAAAGAATAGGGAAAAACAAGAATTTCATGACTCTACCTGTGGTCTATCTTTAATTTCATTTCTTTTGTTAAAAATAAAACAATGAGTATGTTTGGATAC
106430: TCAGTCGGCTCTTAGAGTAGTAACCGCCAGAAAGGAGTCGGAAGAGGTCTCACGAGGCTGTCATCACCGCC^ATGCCCAAGAATAAAG|GTAAAGGAGGTAAAAACAGGCGCAGGGGTAAAAATGAGAATGAATCTGAAAAAAGAGAGTTGGTGTTTAAAGAGGATGGACAAG|AGTATGCTCAGGTAATCAAAATGTTGGGAAATGGACGATTGGAAGCATTGTGTTTTGATGGTGTAAAGAGGTTATGCCATATCAGAGGGAAATTGAGAAAAAAG|GATAACAAAGCTGATGTAATTTTAAAGTACAATGCAGATGAAGCTAGAAGCCTGAAGGCATATGGCGAGCTTCCAGAACATG|CTAAAATCAATGAAACAGACACATTTGGTCCTGGAGATGATGATGAAATCCAGTTTGACGATATTGGAGATGATGATGAAGACATTGATGAT|ATCTAA*ATTGAACCAAGTGTTTTTACATGACAAGTTCTCTGAGGATGGTTCTACAGTTGGGATTTTGGCCATCATCAACCAAGAAGAGAAATTCATTTAGTGTGTAGTTTCTGAAAGCAAACTGATTTATTTTCATTGTTTTAAAGTATTTATTTCTTTAAAAGCTGAGGACACTGAATTACCTTAAGTTAAATGTTAATACTTTATTGTTTTGATGTAATGGAACTTAAGGATAAAAGACCATAATATTTGCTGTTAAAATAAATAAACGAGTGCCTTTCCTACTGTGA
106431: GGCGTCCGGTCCCAGCCTCCTCTGGGAGCGGGCAGTTGGCGACCCTGCACTGACCCGCGTCCCTCCGTCCCGAGCCCGCGCGCCCTCAGAGGGTGCCCGGACAG|ACTGAAGCC^ATGGCGATTCTTTTTGCTGTTGTTGCCAGGGGGACCACTATCCTTGCCAAACATGCTTGGTGTGGAGGAAACTTCCTGGAGGTGACAGAGCAGATTCTGGCTAAGATACCTTCTGAAAATAACAAACTAACGTACTCACATGGCAA|TTATTTGTTTCATTACATCTGCCAAGACAGGATTGTATATCTTTGTATCACTGATGAT|GATTTTGAACGTTCCCGAGCCTTTAATTTTCTGAATGAGATAAAGAAGAGGTTCCAGACTACTTACGGTTCAAGAGCACAGACAGCACTTCCATATGCCATGAATAGCGAGTTCTCAAGTGTCTTAGCTGCACAGCTG|AAGCATCACTCTGAGAATAAGGGCCTAGACAAAGTGATGGAGACTCAAGCCCAAGTGGATGAACTGAAAGGAATCATGGTCAGAAACATAG|TCTGTCACCTTCAAAACTACCAGCAGAAATCTTGCTCGAGCCATGTGTATGAAGAACCTCAAGCTCACTATTATCATCATCATCGTATCAATT|GTGTTCATCTATATCATTGTTTCACCTCTCTGTGGTGGATTTACATGGCCAAGCTGTGTGAAGAAATAGGAAAGAAGAAGTTACCATTAACCAAGGATATGAGAGAACAAGGAGTTAAAAGCAATCCATGTGACTCAAGCCTTTCACATACTGACAGATGGTATCTGCCAGTCTCTTCAACCCTCTTCTCACTTTTTAAAATCTTGTTCCATGCCTCCAGGTTTATCTTTGTCTTATCTACCAGTTTATTCCTGTGA*ACTTCAGATTGAACCATTCATTGCAGCAGTAGCCTTAAAAAGGCTTTTGTTTATTTCTTTGGTTTGTTAACTAGTGTCATCTATTTAGAGAAACATTTTTGTTTTTAATTGCTCAAAGCTGTCGCCGCTAGTCTTATGAGCTATCTACTAAAACTATGGAGAAACTTTGTATGTGCACACAAAAGTATTCAAGAGACAGTATTGCTAACATCTCATCTTAATGTCTTTTGTTATTGAGAAGTTTTAGGTGCTTCAAAACAATATAAATGGATAATAGTTGTTATTTGGGGAATTGTAATGATGTTGGTGCTGCTTCCTTCTAAGAGCTCAGACAAGTAAAGTATGAAACATTCTTATTTCAGTTAGATGGGGAACATTTTGCTAGCCCATTAGAAGCACACAGAATTATCCTTGTCCTCCTAATATTGACTTTCAGGAATAAAGTTCAGTGTGCTGATCATTCACAATACAGTGGATAGCTTGATATCTTCTGTTTTCCCATTGCAGTTGATTTGAGAAGATGAAGGTTTAAATATTGTTGAAAGTTGCAGTTTTTTAAATGTGTTCCTTTTTCTTCTGTGAATATTTAGGGCAATCGTGTCGCTAATAGAATATGTAGTAGAGGGGGTGGGGAGGTAAATTCCTCTGACTTGCCAAAGAAAAAGAAGGGAACCACAGTGGATATGCTAGCATTTTAGCTGTGCAAAGGGAGGTAGTGTGGGAAAAGTGTTTCCATTCTGGGAAAAGCCCAAACCGAATACGGTCAGCAGTCAACTCCAGGGTTTGGGCTTGATTCCTGTTGAATAATAGTTTTGAGCATTCTTTGTGGTTAAATAAATTCTTAAATCTGCCTAGTTTTGATGAATTCTTTTGTGAAACTTGAAAGAGAATAGACAGTATGACATATAGAATTAATACAAAACAGTTTAACAACCATTTAACTGCAGTGTAAGAAAATTGGACTGTAATCATATCGCTACTGGCATCTGTTATCTAGTATGCATTTCTGGTGTGTATCTGAAAGGAAGACATTTTCTACCCTAGATCCAATTGCATTTATTTATCAATAAGTGCCATTAAATTGAAATTATATTACATTTTACACTTTCTCAATGAATGAACAAATTAGTCTGTAGAATCTAGCCACCTGTTTAGCCTAGTCATGTGCCTTGAACATATATGTGTCCCATAATCTGGCTCATGGTACCTGTTCTTCTATCCAAACCTTTCAATTCATGCTACCTGATTCATTTATTTGACATAGATCTTAGGCCCACTTGAACTCTTTTCTTGTTTATCTAGCATAGCACAAACGTTTTTCCAGTCTTCTTTATCAACACTAATGCCTCTTAATTGCATCAGTATTTCCTATTGGAAAATACATCTGTTCCAGAAAAACATTTGGCATTCCTGAATAATTTCCAAATGTTTTTAATCCAAAGAAAAAGGTTTAAAGCTTATTTCCCTTTCTTATACACACCTGAATAAAATTGATGTGCATGTTTTAGGGATCAATTACCTAACTGTTCCTTGGTCTATTTATGTATAAGAATGCTTTTTAAAGCACATGTCTCATTTTAAATGACGCACAAACTGAAGATGTTAATAAAATTTAAGAGTAATACAA
106432: GGCGTCCGGTCCCAGCCTCCTCTGGGAGCGGGCAGTTGGCGACCCTGCACTGACCCGCGTCCCTCCGTCCCGAGCCCGCGCGCCCTCAGAGGGTGCCCGGACAG|ACTGAAGCCATGGCGATTCTTTTTGCTGTTGTTGCCAGGGGGACCACTATCCTTGCCAAACATGCTTGGTGTGGAGGAAACTTCCTGGAGGTGACAGAGCAGATTCTGGCTAAGATACCTTCTGAAAATAACAAACTAACGTACTCACATGGCAA|TTATTTGTTTCATTACATCTGCCAAGACAGGATTGTATATCTTTGTATCACTGATGATGTAA|GATTTTGAACGTTCCCGAGCCTTTAATTTTCTGAATGAGATAAAGAAGAGGTTCCAGACTACTTACGGTTCAAGAGCACAGACAGCACTTCCATATGCC^ATGAATAGCGAGTTCTCAAGTGTCTTAGCTGCACAGCTG|AAGCATCACTCTGAGAATAAGGGCCTAGACAAAGTGATGGAGACTCAAGCCCAAGTGGATGAACTGAAAGGAATCATGGTCAGAAACATAG|ATCTGGTAGCTCAGCGAGGAGAAAGATTGGAATTATTGATTGACAAAACAGAAAATCTTGTGGATTCT|TCTGTCACCTTCAAAACTACCAGCAGAAATCTTGCTCGAGCCATGTGTATGAAGAACCTCAAGCTCACTATTATCATCATCATCGTATCAATT|GTGTTCATCTATATCATTGTTTCACCTCTCTGTGGTGGATTTACATGGCCAAGCTGTGTGAAGAAATAG*GAAAGAAGAAGTTACCATTAACCAAGGATATGAGAGAACAAGGAGTTAAAAGCAATCCATGTGACTCAAGCCTTTCACATACTGACAGATGGTATCTGCCAGTCTCTTCAACCCTCTTCTCACTTTTTAAAATCTTGTTCCATGCCTCCAGGTTTATCTTTGTCTTATCTACCAGTTTATTCCTGTGAACTTCAGATTGAACCATTCATTGCAGCAGTAGCCTTAAAAAGGCTTTTGTTTATTTCTTTGGTTTGTTAACTAGTGTCATCTATTTAGAGAAACATTTTTGTTTTTAATTGCTCAAAGCTGTCGCCGCTAGTCTTATGAGCTATCTACTAAAACTATGGAGAAACTTTGTATGTGCACACAAAAGTATTCAAGAGACAGTATTGCTAACATCTCATCTTAATGTCTTTTGTTATTGAGAAGTTTTAGGTGCTTCAAAACAATATAAATGGATAATAGTTGTTATTTGGGGAATTGTAATGATGTTGGTGCTGCTTCCTTCTAAGAGCTCAGACAAGTAAAGTATGAAACATTCTTATTTCAGTTAGATGGGGAACATTTTGCTAGCCCATTAGAAGCACACAGAATTATCCTTGTCCTCCTAATATTGACTTTCAGGAATAAAGTTCAGTGTGCTGATCATTCACAATACAGTGGATAGCTTGATATCTTCTGTTTTCCCATTGCAGTTGATTTGAGAAGATGAAGGTTTAAATATTGTTGAAAGTTGCAGTTTTTTAAATGTGTTCCTTTTTCTTCTGTGAATATTTAGGGCAATCGTGTCGCTAATAGAATATGTAGTAGAGGGGGTGGGGAGGTAAATTCCTCTGACTTGCCAAAGAAAAAGAAGGGAACCACAGTGGATATGCTAGCATTTTAGCTGTGCAAAGGGAGGTAGTGTGGGAAAAGTGTTTCCATTCTGGGAAAAGCCCAAACCGAATACGGTCAGCAGTCAACTCCAGGGTTTGGGCTTGATTCCTGTTGAATAATAGTTTTGAGCATTCTTTGTGGTTAAATAAATTCTTAAATCTGCCTAGTTTTGATGAATTCTTTTGTGAAACTTGAAAGAGAATAGACAGTATGACATATAGAATTAATACAAAACAGTTTAACAACCATTTAACTGCAGTGTAAGAAAATTGGACTGTAATCATATCGCTACTGGCATCTGTTATCTAGTATGCATTTCTGGTGTGTATCTGAAAGGAAGACATTTTCTACCCTAGATCCAATTGCATTTATTTATCAATAAGTGCCATTAAATTGAAATTATATTACATTTTACACTTTCTCAATGAATGAACAAATTAGTCTGTAGAATCTAGCCACCTGTTTAGCCTAGTCATGTGCCTTGAACATATATGTGTCCCATAATCTGGCTCATGGTACCTGTTCTTCTATCCAAACCTTTCAATTCATGCTACCTGATTCATTTATTTGACATAGATCTTAGGCCCACTTGAACTCTTTTCTTGTTTATCTAGCATAGCACAAACGTTTTTCCAGTCTTCTTTATCAACACTAATGCCTCTTAATTGCATCAGTATTTCCTATTGGAAAATACATCTGTTCCAGAAAAACATTTGGCATTCCTGAATAATTTCCAAATGTTTTTAATCCAAAGAAAAAGGTTTAAAGCTTATTTCCCTTTCTTATACACACCTGAATAAAATTGATGTGCATGTTTTAGGGATCAATTACCTAACTGTTCCTTGGTCTATTTATGTATAAGAATGCTTTTTAAAGCACATGTCTCATTTTAAATGACGCACAAACTGAAGATGTTAATAAAATTTAAGAGTAATACAA
CDS
1: ^ATGGCAGCTGCGGGGAGCCGCAAGAG|GCGCCTGGCGGAGCTGACGGTGGACGAGTTCCTAGCTTCGGGCTTTGACTCCGAGTCCGAATCCGAGTCCGAAAATTCTCCACAAGCGGAGACACGGGAAGCACGCGAGGCTGCCCGGAGTCCGGATAAGCCGGGCGGGAGCCCCTCGGCCAG|CCGGCGTAAAGGCCGTGCCTCTGAGCACAAAGACCAGCTCTCTCGGCTGAAGGACAGAGACCCCGAGTTCTACAAGTTCCTGCAGGAGAATGACCAGAGCCTGCTAAACTTCAGCGACTCGGACAGCTCTGAGGAGGAAGAGGGGCCGTTCCACTCCCTGCCAGATGTGCTGGAG|GAAGCCAGTGAGGAGGAGGATGGAGCGGAGGAAGGAGAAGATGGGGACAGAGTCCCCAGAGGGCTGAAGGGGAAGAAGAATTCTGTTCCTGTGACCGTCGCCATGGTTGAGAGATGGAAGCAGGCAGCAAAG|CAACGCCTCACTCCAAAGCTGTTCCATGAAGTGGTACAGGCGTTCCGAGCAGCTGTGGCCACCACCCGAGGGGACCAGGAAAGTGCTGAGGCCAACAAATTCCAGGTCACGGACAGTGCTG|CATTCAATGCTCTGGTTACCTTCTGCATCAGAGACCTCATTGGCTGTCTCCAGAAGCTGCTGTTTGGAAAGGTGGCAAAGGATAGCAGCAG|ATGTTCCAGCAGGTCGACTTCAACAGGAAGCCAGGGCGCATGA*
2: ^ATGGCAGCTGCGGGGAGCCGCAAGAG|GCGCCTGGCGGAGCTGACGGTGGACGAGTTCCTAGCTTCGGGCTTTGACTCCGAGTCCGAATCCGAGTCCGAAAATTCTCCACAAGCGGAGACACGGGAAGCACGCGAGGCTGCCCGGAGTCCGGATAAGCCGGGCGGGAGCCCCTCGGCCAG|CCGGCGTAAAGGCCGTGCCTCTGAGCACAAAGACCAGCTCTCTCGGCTGAAGGACAGAGACCCCGAGTTCTACAAGTTCCTGCAGGAGAATGACCAGAGCCTGCTAAACTTCAGCGACTCGGACAGCTCTGAGGAGGAAGAGGGGCCGTTCCACTCCCTGCCAGATGTGCTGGAG|GAAGCCAGTGAGGAGGAGGATGGAGCGGAGGAAGGAGAAGATGGGGACAGAGTCCCCAGAGGGCTGAAGGGGAAGAAGAATTCTGTTCCTGTGACCGTCGCCATGGTTGAGAGATGGAAGCAGGCAGCAAAG|CAACGCCTCACTCCAAAGCTGTTCCATGAAGTGGTACAGGCGTTCCGAGCAGCTGTGGCCACCACCCGAGGGGACCAGGAAAGTGCTGAGGCCAACAAATTCCAGGTCACGGACAGTGCTG|CATTCAATGCTCTGGTTACCTTCTGCATCAGAGACCTCATTGGCTGTCTCCAGAAGCTGCTGTTTGGAAAGGTGGCAAAGGATAGCAGCAG|GATGCTGCAGCCGTCCAGCAGCCCGCTCTGGGGGAAGCTTCGTGTGGACATCAAGGCTTACCTGGGCTCGGCCATACAG|CTGGTGTCCTGTCTGTCGGAGACGACGGTGTTGGCGGCCGTGCTGCGGCACATCAGCGTGCTGGTGCCCTGCTTCCTGACCTTCCCCAAGCAGTGCCGCATGCTGCTCAAG|AGAATGGTGATCGTATGGAGCACTGGGGAAGAGTCTCTGCGGGTGCTGGCTTTCCTGGTCCTCAGCAGAGTCTGCCGGCACAAGAAGGACACTTTCCTTGGCCCCGTCCTCAAG|TTTCATGCAGTGGACCTTGACGGAGCTGCTGGCCCTGGAGCCGGGTGTGGCCTACCAGCACGCCTTCCTCTACATCCGCCAGCTCGCCATACACCTGCGCAACGCCATGACCACTCGCAAGAAG|GAAACATACCAGTCTGTGTACAACTGGCAGTATGTGCACTGCCTCTTCCTGTGGTGCCGGGTCCTGAGCACTGCGGGCCCCAGCGAAGCCCTCCAGCCCTTGGTCTACCCCCTTGCCCAAGTCATCATTGGCTGTATCAA|GCTCATCCCCACTGCCCGCTTCTACCCGCTGCGAATGCACTGCATCCGTGCCCTGACGCTGCTCTCGGGGAGCTCGGGGGCCTTCATCCCGGTGCTGCCTTTCATCCTGGAG|ATGTTCCAGCAGGTCGACTTCAACAGGAAGCCAGGGCGCATGAGCTCCAAGCCCATCAACTTCTCCGTGATCCTGAAGCTGTCCAATGTCAACCTGCAGGAGAAGGCGTACCGG|GACGGCCTGGTGGAGCAGCTGTACGACCTCACCCTGGAGTACCTGCACAGCCAGGCACACTGCATCGGCTTCCCGGAGCTGGTGCTGCCTGTGGTCCTGCAG|CTGAAGTCGTTCCTCCGGGAGTGCAAGGTGGCCAACTACTGCCGGCAGGTGCAGCAGCTGCTTGGGAAGGTTCAGGAGAACTCGGCATACATCTGCAGCCGCCGCCAGAGGGTTTCCTTCGGCGTCTCTGA*
3: ^ATGGCAGCTGCGGGGAGCCGCAAGAG|GCGCCTGGCGGAGCTGACGGTGGACGAGTTCCTAGCTTCGGGCTTTGACTCCGAGTCCGAATCCGAGTCCGAAAATTCTCCACAAGCGGAGACACGGGAAGCACGCGAGGCTGCCCGGAGTCCGGATAAGCCGGGCGGGAGCCCCTCGGCCAG|CCGGCGTAAAGGCCGTGCCTCTGAGCACAAAGACCAGCTCTCTCGGCTGAAGGACAGAGACCCCGAGTTCTACAAGTTCCTGCAGGAGAATGACCAGAGCCTGCTAAACTTCAGCGACTCGGACAGCTCTGAGGAGGAAGAGGGGCCGTTCCACTCCCTGCCAGATGTGCTGGAG|GAAGCCAGTGAGGAGGAGGATGGAGCGGAGGAAGGAGAAGATGGGGACAGAGTCCCCAGAGGGCTGAAGGGGAAGAAGAATTCTGTTCCTGTGACCGTCGCCATGGTTGAGAGATGGAAGCAGGCAGCAAAG|CAACGCCTCACTCCAAAGCTGTTCCATGAAGTGGTACAGGCGTTCCGAGCAGCTGTGGCCACCACCCGAGGGGACCAGGAAAGTGCTGAGGCCAACAAATTCCAGGTCACGGACAGTGCTG|CATTCAATGCTCTGGTTACCTTCTGCATCAGAGACCTCATTGGCTGTCTCCAGAAGCTGCTGTTTGGAAAGGTGGCAAAGGATAGCAGCAG|GATGCTGCAGCCGTCCAGCAGCCCGCTCTGGGGGAAGCTTCGTGTGGACATCAAGGCTTACCTGGGCTCGGCCATACAG|CTGGTGTCCTGTCTGTCGGAGACGACGGTGTTGGCGGCCGTGCTGCGGCACATCAGCGTGCTGGTGCCCTGCTTCCTGACCTTCCCCAAGCAGTGCCGCATGCTGCTCAAG|AGAATGGTGATCGTATGGAGCACTGGGGAAGAGTCTCTGCGGGTGCTGGCTTTCCTGGTCCTCAGCAGAGTCTGCCGGCACAAGAAGGACACTTTCCTTGGCCCCGTCCTCAAG|CAAATGTACATCACGTATGTGAGGAACTGCAAGTTCACCTCGCCTGGTGCCCTCCCCTTCATCAGTTTCATGCAGTGGACCTTGACGGAGCTGCTGGCCCTGGAGCCGGGTGTGGCCTACCAGCACGCCTTCCTCTACATCCGCCAGCTCGCCATACACCTGCGCAACGCCATGACCACTCGCAAGAAG|GAAACATACCAGTCTGTGTACAACTGGCAGTATGTGCACTGCCTCTTCCTGTGGTGCCGGGTCCTGAGCACTGCGGGCCCCAGCGAAGCCCTCCAGCCCTTGGTCTACCCCCTTGCCCAAGTCATCATTGGCTGTATCAA|GCTCATCCCCACTGCCCGCTTCTACCCGCTGCGAATGCACTGCATCCGTGCCCTGACGCTGCTCTCGGGGAGCTCGGGGGCCTTCATCCCGGTGCTGCCTTTCATCCTGGAG|ATGTTCCAGCAGGTCGACTTCAACAGGAAGCCAGGGCGCATGAGCTCCAAGCCCATCAACTTCTCCGTGATCCTGAAGCTGTCCAATGTCAACCTGCAGGAGAAGGCGTACCGG|GACGGCCTGGTGGAGCAGCTGTACGACCTCACCCTGGAGTACCTGCACAGCCAGGCACACTGCATCGGCTTCCCGGAGCTGGTGCTGCCTGTGGTCCTGCAG|CTGAAGTCGTTCCTCCGGGAGTGCAAGGTGGCCAACTACTGCCGGCAGGTGCAGCAGCTGCTTGGGAAGGTTCAGGAGAACTCGGCATACATCTGCAGCCGCCGCCAGAGGGTTTCCTTCGGCGTCTCTGAGCAGCAGGCAGTG|GAAGCCTGGGAGAAGCTGACCCGGGAAGAGGGGACACCCCTGACCTTGTACTACAGCCACTGGCGCAAGCTGCGTGACCGGGAGATCCAGCTGGAGATCAGTGGCAAAGAGCGG|CTGGAAGACCTGAACTTCCCTGAGATCAAACGAAGGAAGATGGCTGACAGGAAGGATGAGGACAGGAAGCAATTTAAAGACCTCTTTGACCTGAACAGCTCTGAAGAGGACGACACCGAGGGATTCTCGGAGAGAG|GGATACTGAGGCCCCTGAGCACTCGGCATGGGGTGGAAGACGATGAAGAGGACGAGGAGGAGGGCGAGGAGGACAGCAGCAACTCGGAGG|ATGGAGACCCAGACGCAGAGGCGGGGCTGGCCCCTGGGGAGCTGCAGCAGCTGGCCCAGGGGCCGGAGGACGAGCTGGAGGATCTGCAGCTCTCAGAGGACGACTGA*
4: ^ATGGCAGCTGCGGGGAGCCGCAAGAG|GCGCCTGGCGGAGCTGACGGTGGACGAGTTCCTAGCTTCGGGCTTTGACTCCGAGTCCGAATCCGAGTCCGAAAATTCTCCACAAGCGGAGACACGGGAAGCACGCGAGGCTGCCCGGAGTCCGGATAAGCCGGGCGGGAGCCCCTCGGCCAG|CCGGCGTAAAGGCCGTGCCTCTGAGCACAAAGACCAGCTCTCTCGGCTGAAGGACAGAGACCCCGAGTTCTACAAGTTCCTGCAGGAGAATGACCAGAGCCTGCTAAACTTCAGCGACTCGGACAGCTCTGAGGAGGAAGAGGGGCCGTTCCACTCCCTGCCAGATGTGCTGGAG|GAAGCCAGTGAGGAGGAGGATGGAGCGGAGGAAGGAGAAGATGGGGACAGAGTCCCCAGAGGGCTGAAGGGGAAGAAGAATTCTGTTCCTGTGACCGTCGCCATGGTTGAGAGATGGAAGCAGGCAGCAAAG|CAACGCCTCACTCCAAAGCTGTTCCATGAAGTGGTACAGGCGTTCCGAGCAGCTGTGGCCACCACCCGAGGGGACCAGGAAAGTGCTGAGGCCAACAAATTCCAGGTCACGGACAGTGCTG|CATTCAATGCTCTGGTTACCTTCTGCATCAGAGACCTCATTGGCTGTCTCCAGAAGCTGCTGTTTGGAAAGGTGGCAAAGGATAGCAGCAG|GATGCTGCAGCCGTCCAGCAGCCCGCTCTGGGGGAAGCTTCGTGTGGACATCAAGGCTTACCTGGGCTCGGCCATACAG|CTGGTGTCCTGTCTGTCGGAGACGACGGTGTTGGCGGCCGTGCTGCGGCACATCAGCGTGCTGGTGCCCTGCTTCCTGACCTTCCCCAAGCAGTGCCGCATGCTGCTCAAG|AGAATGGTGATCGTATGGAGCACTGGGGAAGAGTCTCTGCGGGTGCTGGCTTTCCTGGTCCTCAGCAGAGTCTGCCGGCACAAGAAGGACACTTTCCTTGGCCCCGTCCTCAAG|CAAATGTACATCACGTATGTGAGGAACTGCAAGTTCACCTCGCCTGGTGCCCTCCCCTTCATCAGTTTCATGCAGTGGACCTTGACGGAGCTGCTGGCCCTGGAGCCGGGTGTGGCCTACCAGCACGCCTTCCTCTACATCCGCCAGCTCGCCATACACCTGCGCAACGCCATGACCACTCGCAAGAAG|GAAACATACCAGTCTGTGTACAACTGGCAGTATGTGCACTGCCTCTTCCTGTGGTGCCGGGTCCTGAGCACTGCGGGCCCCAGCGAAGCCCTCCAGCCCTTGGTCTACCCCCTTGCCCAAGTCATCATTGGCTGTATCAA|GCTCATCCCCACTGCCCGCTTCTACCCGCTGCGAATGCACTGCATCCGTGCCCTGACGCTGCTCTCGGGGAGCTCGGGGGCCTTCATCCCGGTGCTGCCTTTCATCCTGGAG|CAGGTCGACTTCAACAGGAAGCCAGGGCGCATGAGCTCCAAGCCCATCAACTTCTCCGTGATCCTGAAGCTGTCCAATGTCAACCTGCAGGAGAAGGCGTACCGG|GACGGCCTGGTGGAGCAGCTGTACGACCTCACCCTGGAGTACCTGCACAGCCAGGCACACTGCATCGGCTTCCCGGAGCTGGTGCTGCCTGTGGTCCTGCAG|CTGAAGTCGTTCCTCCGGGAGTGCAAGGTGGCCAACTACTGCCGGCAGGTGCAGCAGCTGCTTGGGAAGGTTCAGGAGAACTCGGCATACATCTGCAGCCGCCGCCAGAGGGTTTCCTTCGGCGTCTCTGAGCAGCAGGCAGTG|GAAGCCTGGGAGAAGCTGACCCGGGAAGAGGGGACACCCCTGACCTTGTACTACAGCCACTGGCGCAAGCTGCGTGACCGGGAGATCCAGCTGGAGATCAGTGGCAAAGAGCGG|CTGGAAGACCTGAACTTCCCTGAGATCAAACGAAGGAAGATGGCTGACAGGAAGGATGAGGACAGGAAGCAATTTAAAGACCTCTTTGACCTGAACAGCTCTGAAGAGGACGACACCGAGGGATTCTCGGAGAGAG|GGATACTGAGGCCCCTGAGCACTCGGCATGGGGTGGAAGACGATGAAGAGGACGAGGAGGAGGGCGAGGAGGACAGCAGCAACTCGGAGG|ATGGAGACCCAGACGCAGAGGCGGGGCTGGCCCCTGGGGAGCTGCAGCAGCTGGCCCAGGGGCCGGAGGACGAGCTGGAGGATCTGCAGCTCTCAGAGGACGACTGA*
5: ^ATGGCAGCTGCGGGGAGCCGCAAGAG|GCGCCTGGCGGAGCTGACGGTGGACGAGTTCCTAGCTTCGGGCTTTGACTCCGAGTCCGAATCCGAGTCCGAAAATTCTCCACAAGCGGAGACACGGGAAGCACGCGAGGCTGCCCGGAGTCCGGATAAGCCGGGCGGGAGCCCCTCGGCCAG|CCGGCGTAAAGGCCGTGCCTCTGAGCACAAAGACCAGCTCTCTCGGCTGAAGGACAGAGACCCCGAGTTCTACAAGTTCCTGCAGGAGAATGACCAGAGCCTGCTAAACTTCAGCGACTCGGACAGCTCTGAGGAGGAAGAGGGGCCGTTCCACTCCCTGCCAGATGTGCTGGAG|GAAGCCAGTGAGGAGGAGGATGGAGCGGAGGAAGGAGAAGATGGGGACAGAGTCCCCAGAGGGCTGAAGGGGAAGAAGAATTCTGTTCCTGTGACCGTCGCCATGGTTGAGAGATGGAAGCAGGCAGCAAAG|CAACGCCTCACTCCAAAGCTGTTCCATGAAGTGGTACAGGCGTTCCGAGCAGCTGTGGCCACCACCCGAGGGGACCAGGAAAGTGCTGAGGCCAACAAATTCCAGGTCACGGACAGTGCTG|CATTCAATGCTCTGGTTACCTTCTGCATCAGAGACCTCATTGGCTGTCTCCAGAAGCTGCTGTTTGGAAAGGTGGCAAAGGATAGCAGCAG|GATGCTGCAGCCGTCCAGCAGCCCGCTCTGGGGGAAGCTTCGTGTGGACATCAAGGCTTACCTGGGCTCGGCCATACAG|CTGGTGTCCTGTCTGTCGGAGACGACGGTGTTGGCGGCCGTGCTGCGGCACATCAGCGTGCTGGTGCCCTGCTTCCTGACCTTCCCCAAGCAGTGCCGCATGCTGCTCAAG|AGAATGGTGATCGTATGGAGCACTGGGGAAGAGTCTCTGCGGGTGCTGGCTTTCCTGGTCCTCAGCAGAGTCTGCCGGCACAAGAAGGACACTTTCCTTGGCCCCGTCCTCAAG|CAAATGTACATCACGTATGTGAGGAACTGCAAGTTCACCTCGCCTGGTGCCCTCCCCTTCATCAGTTTCATGCAGTGGACCTTGACGGAGCTGCTGGCCCTGGAGCCGGGTGTGGCCTACCAGCACGCCTTCCTCTACATCCGCCAGCTCGCCATACACCTGCGCAACGCCATGACCACTCGCAAGAAG|GAAACATACCAGTCTGTGTACAACTGGCAGTATGTGCACTGCCTCTTCCTGTGGTGCCGGGTCCTGAGCACTGCGGGCCCCAGCGAAGCCCTCCAGCCCTTGGTCTACCCCCTTGCCCAAGTCATCATTGGCTGTATCAA|GCTCATCCCCACTGCCCGCTTCTACCCGCTGCGAATGCACTGCATCCGTGCCCTGACGCTGCTCTCGGGGAGCTCGGGGGCCTTCATCCCGGTGCTGCCTTTCATCCTGGAG|ATGTTCCAGCAGGTCGACTTCAACAGGAAGCCAGGGCGCATGAGCTCCAAGCCCATCAACTTCTCCGTGATCCTGAAGCTGTCCAATGTCAACCTGCAGGAGAAGGCGTACCGG|GACGGCCTGGTGGAGCAGCTGTACGACCTCACCCTGGAGTACCTGCACAGCCAGGCACACTGCATCGGCTTCCCGGAGCTGGTGCTGCCTGTGGTCCTGCAG|CTGAAGTCGTTCCTCCGGGAGTGCAAGGTGGCCAACTACTGCCGGCAGGTGCAGCAGCTGCTTGGGAAGGTTCAGGAGAACTCGGCATACATCTGCAGCCGCCGCCAGAGGGTTTCCTTCGGCGTCTCTGAGCAGCAGGCAGTG|GAAGCCTGGGAGAAGCTGACCCGGGAAGAGGGGACACCCCTGACCTTGTACTACAGCCACTGGCGCAAGCTGCGTGACCGGGAGATCCAGCTGGAGATCAGTGGCAAAGAGCGG|CTGGAAGACCTGAACTTCCCTGAGATCAAACGAAGGAAGATGGCTGACAGGAAGGATGAGGACAGGAAGCAATTTAAAGACCTCTTTGACCTGAACAGCTCTGAAGAGGACGACACCGAGGGATTCTCGGAGAGAGGTGGGGCCTGCGTGGTGCTCCCAGGGGAAGGGTGGGCCTGGAGGGCTCTGCTGGACTTCCCAGAGCCACGAGGGCCACCTGTACCCATCCTGCAGGGGGCTCACCAGTCTCTGGCCCAGCTGGGGCCAACCTCAGTGTTGCCAGGCTTCTGGTGCCAGCGCCTTCCCTCCTTGAAGTGA*
---
106428: ^ATGGAACCGGGGTGTGACGAGTTCCTGCCGCCACCGGAGTGCCCGGTTTTTGAGCCTAGCTGGGCTGAATTCCAAGACCCGCTTGGCTACATTGCGAAAATAAGGCCCATAGCAGAGAAGTCTGGCATCTGCAAAATCCGCCCACCCGCG|GATTGGCAGCCTCCTTTTGCAGTAGAAGTTGACAATTTCAGATTTACTCCTCGCGTCCAAAGGCTAAATGAACTGGAG|GCCCAAACTAGAGTGAAATTGAACTATTTGGATCAGATTGCAAAATTCTGGGAAATTCAAGGCTCCTCTTTAAAGATTCCCAATGTGGAGCGGAAGATCTTGGACCTCTACAGCCTTAGTAAG|ATTGTGATTGAGGAAGGTGGCTATGAAGCCATCTGCAAGGATCGTCGGTGGGCTCGAGTTGCCCAGCGTCTCCACTACCCACCAGGCAAAAACATTGGCTCCCTGCTACGATCACATTACGAACGCATTATTTACCCCTATGAAATGTTTCAGTCTGGAGCCAACCATGTG|CAATGTAACACACACCCGTTTGACAATGAGGTAAAAGATAAGGAATACAAGCCCCACAGCATCCCCCTTAGACAGTCTGTGCAGCCTTCAAAGTTCAGCAGCTACAGTCGACGGGCAAAAAGGCTACAGCCTGAT|CCAGAGCCTACAGAGGAGGACATTGAGAAGCATCCAGAGCTAAAGAAGTTACAGATATATGGGCCAGGTCCCAAAATGATGGGCTTGGGCCTTATGGCTAAGGATAAGGATAAGACTGTGCATAAGAAAG|TCACATGCCCCCCAACTGTTACGGTGAAGGATGAGCAAAGTGGAGGTGGGAACGTGTCATCAACATTGCTCAAGCAGCACTTGAGCCTAGAGCCCTGCACTAAGACAACCATGCAACTTCGAAAGAATCACAGCAGTGCCCAGTTT|ATTGACTCATATATTTGCCAAGTATGCTCCCGTGGGGATGAAGATGATAAGCTTCTTTTCTGTGATGGCTGTGATGACAATTACCACATCTTCTGCTTGTTACCACCCCTTCCTGAAATCCCCAGAGGCATCTGGAGGTGCCCAAAATGTATCTTGGCG|GAGTGTAAACAGCCTCCTGAAGCTTTTGGATTTGAACAGGCTACCCAGGAGTACAGTTTGCAGAGTTTTGGTGAAATGGCTGATTCCTTCAAGTCCGACTACTTCAACATGCCTGTACAT|ATGGTGCCTACAGAACTTGTAGAGAAGGAATTCTGGAGGCTGGTGAGCAGCATTGAGGAAGACGTGACAGTTGAATATGGAGCTGATATTCATTCCAAAGAATTTGGCAGTGGCTTTCCTGTCAGCAATAGCAAACAAAACTTATCTCCTGAGGAGAAG|GAGTATGCGACCAGTGGTTGGAACCTGAATGTGATGCCAGTGCTAGATCAGTCTGTTCTCTGTCACATCAATGCAGACATCTCAGGCATGAAGGTGCCCTGGCTGTACGTGGGCATGGTTTTCTCAGCATTTTGTTGGCATATTGAGGATCACTGGAGTTACTCTATTAACTATCTGCATTG|GGGTGAGCCGAAGACCTGGTATGGTGTACCCTCCCTGGCAGCAGAGCATTTGGAGGAGGTGATGAAGATGCTGACACCTGAGCTGTTTGATAGCCAGCCTGATCTCCTACACCAGCTTGTCACTCTCATGAATCCCAACACTTTGATGTCCCATGGTGTGCCA|GTTGTCCGCACAAACCAGTGTGCAGGGGAGTTTGTCATCACTTTTCCTCGTGCTTACCACAGTGGTTTTAACCAAGGCTACAATTTTGCTGAAGCTGTCAACTTTTGTACTGCTGACTGG|CTACCTGCTGGACGCCAGTGCATTGAACACTACCGCCGGCTCCGGCGCTATTGTGTCTTCTCCCACGAGGAGCTCATCTGCAAGATGGCTGCCTTCCCAGAGACGTTGGATCTCAATCTAGCAGTAGCTGTGCACAAGGAGATGTTCATTATGGTTCAGGAGGAGCGACGTCTACGAAAGGCCCTTTTGGAGAAG|GGCGTCACGGAGGCTGAGCGAGAGGCTTTTGAGCTGCTCCCAGATGATGAACGCCAGTGCATCAAGTGCAAGACCACGTGCTTCTTGTCAGCCCTGGCCTGCTACGACTGCCCAGATGGCCTTGTATGCCTTTCCCACATCAATGACCTCTGCAAGTGCTCTAGTAGCCGACAGTACCTCCG|GTATCGGTACACCTTGGATGAGCTCCCCACCATGCTGCATAAACTGAAGATTCGGGCTGAGTCTTTTGACACCTGGGCCAACAAAGTGCGAGTGGCCTTGGAGGTGGAGGATGGCCGTAAACGCA|GCTTTGAAGAGCTAAGGGCACTGGAGTCTGAGGCTCGTGAGAGGAGGTTTCCTAATAGTGAGCTGCTTCAGCGACTGAAGAACTGCCTGAGTGAGGTGGAGGCTTGTATTGCTCAAGTCCTGGGGCTGGTCAGTGGTCAGGTGGCCAG|GATGGACACTCCACAGCTGACCTTGACTGAACTCCGGGTCCTTCTTGAGCAGATGGGCAGCCTGCCCTGTGCCATGCATCAGATTGGGGATGTCAAG|GTTCTTTCCTGGAAGTGGCGGAGATATGTGTTCCCATACCATCTCTGTGTGTACAGCATGCAAGGAAATATCCTTCCAGACTGA*
106429: ^ATGGCTGCCTTCCCAGAGACGTTGGATCTCAATCTAGCAGTAGCTGTGCACAAGGAGATGTTCATTATGGTTCAGGAGGAGCGACGTCTACGAAAGGCCCTTTTGGAGAAG|GGCGTCACGGAGGCTGAGCGAGAGGCTTTTGAGCTGCTCCCAGATGATGAACGCCAGTGCATCAAGTGCAAGACCACGTGCTTCTTGTCAGCCCTGGCCTGCTACGACTGCCCAGATGGCCTTGTATGCCTTTCCCACATCAATGACCTCTGCAAGTGCTCTAGTAGCCGACAGTACCTCCG|GTATCGGTACACCTTGGATGAGCTCCCCACCATGCTGCATAAACTGAAGATTCGGGCTGAGTCTTTTGACACCTGGGCCAACAAAGTGCGAGTGGCCTTGGAGGTGGAGGATGGCCGTAAACGCA|GCTTTGAAGAGCTAAGGGCACTGGAGTCTGAGGCTCGTGAGAGGAGGTTTCCTAATAGTGAGCTGCTTCAGCGACTGAAGAACTGCCTGAGTGAGGTGGAGGCTTGTATTGCTCAAGTCCTGGGGCTGGTCAGTGGTCAGGTGGCCAG|GATGGACACTCCACAGCTGACCTTGACTGAACTCCGGGTCCTTCTTGAGCAGATGGGCAGCCTGCCCTGTGCCATGCATCAGATTGGGGATGTCAAG|GATGTCCTGGAACAGGTGGAGGCCTATCAAGCTGAGGCTCGTGAGGCTCTGGCCACACTGCCCTCTAGTCCAGGGCTATTGCGGTCCCTGTTGGAGAGGGGGCAGCAGCTGGGTGTAGAGGTGCCTGAAGCCCATCAGCTTCAGCAGCAGGTGGAGCAGGCGCAATGGCTAGATGAAGTGAAGCAGGCCCTGGCCCCTTCTGCTCACAGGGGCTCTCTGGTCATCATGCAGGGGCTTTTGGTTATGGGTGCCAAGATAGCCTCCAGCCCTTCTGTGGACAAGGCCCGGGCTGAGCTGCAAGAACTACTGACCATTGCAGAGCGCTGGGAAGAAAAGGCTCATTTCTGCCTGGAGGCCAG|GCAGAAGCATCCACCAGCCACATTGGAAGCCATAATTCGTGAGACAGAAAACATCCCTGTTCACCTGCCTAACATCCAGGCTCTCAAAGAAGCTCTGACTAAGGCACAAGCTTGGATTGCTGATGTGGATGAGATCCAA|AATGGTGACCACTACCCCTGTCTAGATGACTTGGAGGGCCTGGTGGCTGTGGGCCGGGACCTGCCTGTGGGGCTGGAAGAGCTGAGACAGCTAGAGCTGCAGGTATTGACAGCACATTCCTGGAGAGAGAAGGCCTCCAAGACCTTTCTCAAGAAGAATTCTTGCTACACACTGCTTGAG|GTGCTTTGCCCGTGTGCAGACGCTGGCTCAGACAGCACCAAGCGTAGCCGGTGGATGGAGAAGGCGCTGGGGTTGTACCAGTGTGACACAGAGCTGCTGGGGCTGTCTGCACAGGACCTCAGAGACCCAGGCTCTGTG|ATTGTGGCCTTCAAGGAAGGGGAACAGAAGGAGAAGGAGGGTATCCTGCAGCTGCGTCGCACCAACTCAGCCAAGCCCAGTCCACTGGCACCATCCCTCATGGCCTCTTCTCCGACTTCTATCTGTGTGTGTGGGCAGGTGCCAGCTGGGGTGGGAGTTCTGCAGTGTGACCTGTGTCAGGACTGGTTCCATGGGCAGTGTGTGTCAGTGCCCCATCTCCTCACCTCTCCAAAGCCCAGTCTCACTTCATCTCCACTGCTAGCCTGGTGGGAATGGGACACAAAATTCCTGTGTCCACTGTGTATGCGCTCACGACGGCCACGCCTAGAGACAATCCTAGCCTTGCTGGTTGCCCTGCAGAGGCTGCCCGTGCGGCTGCCTGAGGGTGAGGCCCTTCAGTGTCTCACAGAGAGGGCCATTGGCTGGCAAGACCGTGCCAGAAAGGCTCTGGCCTCTGAAGATGTGACTGCTCTGTTGCGACAGCTGGCTGAGCTTCGCCAACAGCTACAGGCCAAACCCAGACCAGAGGAGGCCTCAGTCTACACTTCAGCCACTGCCTGTGACCCTATCAGAGAAGGCAGTGGCAACAATATTTCTAAG|GTCCAAGGGCTGCTGGAGAATGGAGACAGTGTGACCAGTCCTGAGAACATGGCTCCAGGAAAGGGCTCTG|ACCTGGAGCTACTGTCCTCACTGTTGCCGCAGTTGACTGGCCCTGTGTTGGAGCTGCCTGAGGCAATCCGGGCTCCCCTGGAGGAGCTCATGATGGAAGGGGACCTGCTTGAGGTGACCCTGGATGAGAACCACAGCATCTGGCAGCTGCTGCAGGCTGGACAGCCTCCAGACCTGGACAGAATTCGCACACTTCTGGAG|CTGGAAAAATTTGAACATCAAGGGAGTCGGACAAGGAGCCGGGCTCTGGAGAGGCGACGGCGGCGGCAGAAGGTGGATCAGGGTAGAAACGTTGAGAATCTTGTTCAACAGGAGCTTCAGTCAAAAAGGGCTCGGAGCTCAGGGATTATGTCTCAGGTGGGCCGAGAAGAAGAACATTATCAGGAGAAAGCAGACCGTGAAAATATGTTCCTGACACCTTCCACAGACCACAGCCCTTTCTTGAAAGGAAACCAAAATAGCTTACAACACAAGGATTCAGGCTCTTCAGCTGCTTGTCCTTCTTTAATGCCTTTGCTACAACTCTCCTACTCTGATGAGCAACAGTTGTGA*
106430: ^ATGCCCAAGAATAAAG|GTAAAGGAGGTAAAAACAGGCGCAGGGGTAAAAATGAGAATGAATCTGAAAAAAGAGAGTTGGTGTTTAAAGAGGATGGACAAG|AGTATGCTCAGGTAATCAAAATGTTGGGAAATGGACGATTGGAAGCATTGTGTTTTGATGGTGTAAAGAGGTTATGCCATATCAGAGGGAAATTGAGAAAAAAG|GATAACAAAGCTGATGTAATTTTAAAGTACAATGCAGATGAAGCTAGAAGCCTGAAGGCATATGGCGAGCTTCCAGAACATG|CTAAAATCAATGAAACAGACACATTTGGTCCTGGAGATGATGATGAAATCCAGTTTGACGATATTGGAGATGATGATGAAGACATTGATGAT|ATCTAA*
106431: ^ATGGCGATTCTTTTTGCTGTTGTTGCCAGGGGGACCACTATCCTTGCCAAACATGCTTGGTGTGGAGGAAACTTCCTGGAGGTGACAGAGCAGATTCTGGCTAAGATACCTTCTGAAAATAACAAACTAACGTACTCACATGGCAA|TTATTTGTTTCATTACATCTGCCAAGACAGGATTGTATATCTTTGTATCACTGATGAT|GATTTTGAACGTTCCCGAGCCTTTAATTTTCTGAATGAGATAAAGAAGAGGTTCCAGACTACTTACGGTTCAAGAGCACAGACAGCACTTCCATATGCCATGAATAGCGAGTTCTCAAGTGTCTTAGCTGCACAGCTG|AAGCATCACTCTGAGAATAAGGGCCTAGACAAAGTGATGGAGACTCAAGCCCAAGTGGATGAACTGAAAGGAATCATGGTCAGAAACATAG|TCTGTCACCTTCAAAACTACCAGCAGAAATCTTGCTCGAGCCATGTGTATGAAGAACCTCAAGCTCACTATTATCATCATCATCGTATCAATT|GTGTTCATCTATATCATTGTTTCACCTCTCTGTGGTGGATTTACATGGCCAAGCTGTGTGAAGAAATAGGAAAGAAGAAGTTACCATTAACCAAGGATATGAGAGAACAAGGAGTTAAAAGCAATCCATGTGACTCAAGCCTTTCACATACTGACAGATGGTATCTGCCAGTCTCTTCAACCCTCTTCTCACTTTTTAAAATCTTGTTCCATGCCTCCAGGTTTATCTTTGTCTTATCTACCAGTTTATTCCTGTGA*
106432: ^ATGAATAGCGAGTTCTCAAGTGTCTTAGCTGCACAGCTG|AAGCATCACTCTGAGAATAAGGGCCTAGACAAAGTGATGGAGACTCAAGCCCAAGTGGATGAACTGAAAGGAATCATGGTCAGAAACATAG|ATCTGGTAGCTCAGCGAGGAGAAAGATTGGAATTATTGATTGACAAAACAGAAAATCTTGTGGATTCT|TCTGTCACCTTCAAAACTACCAGCAGAAATCTTGCTCGAGCCATGTGTATGAAGAACCTCAAGCTCACTATTATCATCATCATCGTATCAATT|GTGTTCATCTATATCATTGTTTCACCTCTCTGTGGTGGATTTACATGGCCAAGCTGTGTGAAGAAATAG*dat %>%
# filter(str_detect(sample, "^GM")) %>%
mutate(lenCDS = str_length(CDS)/3) %>%
dplyr::select(ORF.translation.approach, sample, Read, lenCDS) %>%
distinct() %>%
pivot_wider(names_from = "ORF.translation.approach", values_from="lenCDS") %>%
ggplot(aes(x=firstORF, y=longestORF)) +
# geom_point(alpha=0.1) +
geom_hex(bins=100) +
scale_fill_viridis_c(trans='log10') +
# scale_x_continuous(trans='log10') +
# scale_y_continuous(trans='log10') +
facet_wrap(~sample) +
labs(x="first ORF len (AA)", "longest ORF len (AA)")
dat %>%
mutate(lenCDS = str_length(CDS)/3) %>%
dplyr::select(ORF.translation.approach, sample, Read, lenCDS) %>%
distinct() %>%
pivot_wider(names_from = "ORF.translation.approach", values_from="lenCDS") %>%
ggplot(aes(x=firstORF, y=longestORF)) +
# geom_point(alpha=0.1) +
geom_hex(bins=100) +
scale_fill_viridis_c(trans='log10') +
scale_x_continuous(trans='log10') +
scale_y_continuous(trans='log10') +
facet_wrap(~sample) +
labs(x="first ORF len (AA)", "longest ORF len (AA)")
Ok I think that generally makes sense… Often the firstORF is the same
length as the longest ORF… Other times the longest ORF is longer than
the first ORF… In a smaller minority of cases, the first ORF is longer
than the longest ORF (because when translating from the first ORF, I
allowed no-stop translations, while I did not allow for that when
identifying the longest ORF).
Next let’s try classifying reads by different critera…
dat %>%
filter(!is.na(CDS)) %>%
count(ORF.translation.approach, sample) ORF.translation.approach sample n
1: firstORF CTRL1_shRNA.SAMEA8691110 41134
2: firstORF CTRL2_shRNA.SAMEA8691111 93331
3: firstORF GM1 61755
4: firstORF GM2 85515
5: firstORF GM3 44912
6: firstORF GM4 86563
7: firstORF SMG6_SMG7_shRNA.SAMEA8691113 23865
8: longestORF CTRL1_shRNA.SAMEA8691110 174652
9: longestORF CTRL2_shRNA.SAMEA8691111 283296
10: longestORF GM1 71951
11: longestORF GM2 89851
12: longestORF GM3 52719
13: longestORF GM4 91108
14: longestORF SMG6_SMG7_shRNA.SAMEA8691113 92621dat.PlotPieChart <- dat %>%
# sample_n(1000) %>%
# filter(!is.na(CDS)) %>%
mutate(InLastExon = str_detect(Col13, "(^|\\|)[ACGTNacgtn]*+\\*[ACGTNacgtn]*+$")) %>%
mutate(DistanceToStartUnder150 = str_length(CDS) < 150) %>%
mutate(ExonLengthOver407 = str_length(str_extract(Col13, "(^|\\|)[ACGTNacgtn]*+\\*[ACGTNacgtn]*+\\|")) > 407) %>%
mutate(Is50NtUpstreamOfLastEJC = str_detect(Col13, "\\*[ACGTNacgtn]{0,50}\\|[ACGTNacgtn]*+$")) %>%
mutate(NoStop = str_detect(Col13, "\\^") & str_detect(Col13, "\\*", negate = T)) %>%
mutate(Category = case_when(
NoStop ~ "No stop",
InLastExon ~ "Last exon",
DistanceToStartUnder150 ~ "Start proximal",
ExonLengthOver407 ~ "Long exon",
Is50NtUpstreamOfLastEJC ~ "50 nt rule",
is.na(CDS) ~ "No CDS",
TRUE ~ "Trigger NMD"
))Some tester code to help me manually inspect some reads from each category on IGV to ensure the categorization was done right.
set.seed(0)
dat.PlotPieChart %>%
filter(sample=="CTRL1_shRNA.SAMEA8691110" & ORF.translation.approach=="firstORF") %>%
group_by(Category) %>%
sample_n(5) %>%
ungroup() %>%
dplyr::select(Read, Category, Col7, Col8) %>%
mutate(location = str_replace(Read, "^(.+?)_(.+?)_(.+?)_.+$", "\\1:\\2-\\3"))
dat.PlotPieChart %>%
filter(sample=="CTRL1_shRNA.SAMEA8691110" & ORF.translation.approach=="firstORF") %>%
filter(str_detect(Read, "ERR5880581.1269884")) %>%
dplyr::select(Read, Category, Col7, Col8)Now plot fraction in each category… Only include chromosomal reads
dat.PlotPieChart %>%
filter(str_detect(Read, "^chr[1-9]")) %>%
# filter(sample == "CTRL1_shRNA.SAMEA8691110")
count(Category, ORF.translation.approach, sample) %>%
filter(!Category=="No CDS") %>%
mutate(sample = str_replace(sample, "(.+?)\\..+$", "\\1")) %>%
ggplot(aes(x=sample, fill=Category, y=n)) +
geom_col(position="fill") +
# geom_col(position="stack") +
facet_wrap(~ORF.translation.approach) +
Rotate_x_labels +
labs(y="fractionReads", fill="Lindeboom\ncategory")
Cool… Sort of makes sense, but let’s also plot by number of introns…
Update
I will continue this analysis in another notebook… I updated the snakemake to include the Lindeboom logic in creating the bed files that I read in here, so in the next notebook I will do that stuff in R
sessionInfo()R version 4.2.0 (2022-04-22)
Platform: x86_64-pc-linux-gnu (64-bit)
Running under: CentOS Linux 7 (Core)
Matrix products: default
BLAS/LAPACK: /software/openblas-0.3.13-el7-x86_64/lib/libopenblas_haswellp-r0.3.13.so
locale:
[1] LC_CTYPE=en_US.UTF-8 LC_NUMERIC=C LC_TIME=C
[4] LC_COLLATE=C LC_MONETARY=C LC_MESSAGES=C
[7] LC_PAPER=C LC_NAME=C LC_ADDRESS=C
[10] LC_TELEPHONE=C LC_MEASUREMENT=C LC_IDENTIFICATION=C
attached base packages:
[1] stats graphics grDevices utils datasets methods base
other attached packages:
[1] forcats_0.5.1 stringr_1.4.0 dplyr_1.0.9 purrr_0.3.4
[5] readr_2.1.2 tidyr_1.2.0 tibble_3.1.7 ggplot2_3.3.6
[9] tidyverse_1.3.1 data.table_1.14.2
loaded via a namespace (and not attached):
[1] Rcpp_1.0.8.3 lattice_0.20-45 lubridate_1.8.0 assertthat_0.2.1
[5] rprojroot_2.0.3 digest_0.6.29 utf8_1.2.2 R6_2.5.1
[9] cellranger_1.1.0 backports_1.4.1 reprex_2.0.1 evaluate_0.15
[13] highr_0.9 httr_1.4.3 pillar_1.7.0 rlang_1.0.2
[17] readxl_1.4.0 rstudioapi_0.13 hexbin_1.28.3 jquerylib_0.1.4
[21] R.oo_1.24.0 R.utils_2.11.0 rmarkdown_2.14 labeling_0.4.2
[25] munsell_0.5.0 broom_0.8.0 compiler_4.2.0 httpuv_1.6.5
[29] modelr_0.1.8 xfun_0.30 pkgconfig_2.0.3 htmltools_0.5.2
[33] tidyselect_1.1.2 workflowr_1.7.0 viridisLite_0.4.0 fansi_1.0.3
[37] crayon_1.5.1 tzdb_0.3.0 dbplyr_2.1.1 withr_2.5.0
[41] later_1.3.0 R.methodsS3_1.8.1 grid_4.2.0 jsonlite_1.8.0
[45] gtable_0.3.0 lifecycle_1.0.1 DBI_1.1.2 git2r_0.30.1
[49] magrittr_2.0.3 scales_1.2.0 cli_3.3.0 stringi_1.7.6
[53] farver_2.1.0 fs_1.5.2 promises_1.2.0.1 xml2_1.3.3
[57] bslib_0.3.1 ellipsis_0.3.2 generics_0.1.2 vctrs_0.4.1
[61] tools_4.2.0 glue_1.6.2 hms_1.1.1 fastmap_1.1.0
[65] yaml_2.3.5 colorspace_2.0-3 rvest_1.0.2 knitr_1.39
[69] haven_2.5.0 sass_0.4.1