Pax's Pharmacopoeia - insulin-chat

Pax1l 6/20/2022 2:01 PM

3

1

Original message was deleted or could not be loaded.

Nice!!! So happy for you!!

2

Nunex

Nice!!! So happy for you!!

Thank you tehe

Original message was deleted or could not be loaded.

Based on these experiences with Insulin are you now planning on permanently incorporating it into your stack? (edited)

Potential

Based on these experiences with Insulin are you now planning on permanently incorporating it into your stack? (edited)

South Korea has revised a bill to regulate the purchase of RX drugs from non-doctors. This is going to start soon. so, I'll only be able to purchase experimental peptides that aren't for humans. Therefore, I won't be able to maintain the insulin stack.

IGF2 it is

Pax1l

IGF2 it is

yeah right

our bodies produce it naturally

4:11 PM

and I think intranasal use it will behave just like insulin but magnitudes stronger

2

Pax1l

and I think intranasal use it will behave just like insulin but magnitudes stronger

Frankly, it is very experimental. Gathering users interested in IN-IGF2, many people need to participate in self-experiments and share data.

9:47 PM

It will be our experimental project after DFO.

All these IN insulin studies are from decade or two ago. Why am I just hearing it now? Are they suppressing this information? Anyways, any injectable regular human insulin is fine? Any reason to choose a brand over another?

Isn't insulin dangerous for non diabetics?

PhenylKira

Isn't insulin dangerous for non diabetics?

https://pubmed.ncbi.nlm.nih.gov/25028522/

Central insulin administration improves whole-body insulin sensitiv...

Animal studies suggest that insulin action in the brain is involved in the regulation of peripheral insulin sensitivity. Whether this holds true in humans is unknown. Using intranasal application of insulin to the human brain, we studied the impacts of brain insulin action on whole-body insulin sens …

2:26 PM

https://link.springer.com/article/10.1007/s00125-012-2528-y

Nasal insulin changes peripheral insulin sensitivity simultaneously...

Diabetologia - Impaired insulin sensitivity is a major factor leading to type 2 diabetes. Animal studies suggest that the brain is involved in the regulation of insulin sensitivity. We investigated...

2:27 PM

https://clinicaltrials.gov/ct2/show/NCT01767909

The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIF...

The Study of Nasal Insulin in the Fight Against Forgetfulness (SNIFF) - Full Text View.

PhenylKira

Isn't insulin dangerous for non diabetics?

Read paper which I posted.

I will read them all

hehe

PhenylKira

Isn't insulin dangerous for non diabetics?

https://pubmed.ncbi.nlm.nih.gov/29508509/

A total of 38 studies in 1092 individuals receiving acute human intranasal insulin treatment and 18 studies in 832 individuals receiving human intranasal insulin treatment lasting between 21 days and 9.7 years were identified. No cases of symptomatic hypoglycaemia or severe adverse events (AEs) were reported. Transient local side effects in the nasal area were frequently experienced after intranasal insulin and placebo spray, while other AEs were less commonly reported.

Safety of intranasal human insulin: A review - PubMed

Our retrospective review of published studies on intranasal insulin did not reveal any safety concerns; however, there were insufficient data to ensure the long-term safety of this method of chronic insulin administration. Improved insulin preparations that cause less nasal irritation would be desir …

3

Pax1l pinned a message to this channel. 6/22/2022 5:20 PM

Read the papers that Pax posts carefully.

5:22 PM

Everything he posted.

shung🌞🌈

All these IN insulin studies are from decade or two ago. Why am I just hearing it now? Are they suppressing this information? Anyways, any injectable regular human insulin is fine? Any reason to choose a brand over another?

Are they suppressing this information? I don't think it's an active suppression but when science talks the news whispers. There's just a huge wash of information we're all exposed to on a daily basis at every level of affluence in society. Some people are better able to see these patterns than others. I know one thing for sure is that the government at large provides funding through the NIH for so many of these studies. The NIH runs the public library of medicine where much of the great wealth of medical literature from the past decades are aggregated and easily available. Research scientists are great for applying their knowledge towards writing and making scientific articles but there's a huge gap between scientists in academia and the public at large. The mass media isn't necessarily actively searching through the literature like I may be or people in the nootropics/biohacking space would be. This is what I'd ascribe to be known as the great filter. There's just so much information people really have to understand what's critically important about differing mechanisms in biology and pathology of degenerative disorders to begin to become better educated on the subject. It's just like learning an instrument and I've probably put 10k hours into learning about biology to get to this point

1

I understand. Makes sense.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2804944/

Intranasal Insulin Administration Dose-Dependently Modulates Verbal...

Intranasal insulin administration raises central nervous system (CNS) insulin levels in humans and acutely facilitates verbal memory in patients with Alzheimer’s disease (AD), an effect that may differ by APOE genotype. The purpose of this study ...

https://diabetesjournals.org/diabetes/article-abstract/doi/10.2337/db21-0644/147086/Dopamine-Negatively-Regulates-Insulin-Secretion

Dopamine Negatively Regulates Insulin Secretion Through Activation ...

There is increasing evidence that dopamine (DA) functions as a negative regulator of glucose-stimulated insulin secretion (GSIS); however, the underlying molecu

5:54 PM

https://diabetesjournals.org/diabetes/article/59/6/1338/33418/Chronic-Rapamycin-Treatment-Causes-Glucose (edited)

Chronic Rapamycin Treatment Causes Glucose Intolerance and Hyperlip...

OBJECTIVE. The mammalian target of rapamycin (mTOR)/p70 S6 kinase 1 (S6K1) pathway is a critical signaling component in the development of obesity-linked insuli

This is just the stereotypical human insulin right? Like the kind used for diabetics?

Original message was deleted or could not be loaded.

I see, I may look into yeast for a higher yield then; or just get some basic E. Coli and rip the plasmid somewhere.

10:49 PM

Ty

Original message was deleted or could not be loaded.

Insulin is extracted from genetically modified bacteria using deep fermentation

11:36 PM

Basically a plasmid is a disk of DNA that codes RNA which makes up sets of codons which are expressed during protein synthesis. For E. Coli you just put a plasmid in it for it to produce a specific product. (edited)

11:39 PM

I know a guy who did it for yeast if I can recall, so I may see if he’ll open-source me the plasmid for it

1

https://diabetesjournals.org/diabetes/article/61/9/2261/14797/Intranasal-Insulin-Suppresses-Food-Intake-via

Intranasal Insulin Suppresses Food Intake via Enhancement of Brain ...

Cerebral insulin exerts anorexic effects in humans and animals. The underlying mechanisms, however, are not clear. Because insulin physiologically facilitates g

Original message was deleted or could not be loaded.

Ye bacteria and yeast are like little factories I love them

Pax1l

https://pubmed.ncbi.nlm.nih.gov/29508509/

A total of 38 studies in 1092 individuals receiving acute human intranasal insulin treatment and 18 studies in 832 individuals receiving human intranasal insulin treatment lasting between 21 days and 9.7 years were identified. No cases of symptomatic hypoglycaemia or severe adverse events (AEs) were reported. Transient local side effects in the nasal area were frequently experienced after intranasal insulin and placebo spray, while other AEs were less commonly reported.

"Our retrospective review of published studies on intranasal insulin did not reveal any safety concerns; however, there were insufficient data to ensure the long-term safety of this method of chronic insulin administration. " 9.7 years isn't considered longterm lol?

IKR

서진

Frankly, it is very experimental. Gathering users interested in IN-IGF2, many people need to participate in self-experiments and share data.

I have been looking at purchasing IGF-2 peptide online. If you or @Pax1l have any ideas of dosing and duration, I’m all ears.

1

7mcg 3 times daily

6:30 AM

1mg will last around 40 days

How are you basing this? HED from mice?

6:31 AM

PeptideScience.com sells 1mg igf2 for $95 iirc.

quantifying the affinity igf2 has and reducing from the dosage of insulin by a factor of 10

Okay I will take this into consideration.

6:34 AM

Is it beneficial at my age? I don’t think I have Alzheimer’s or any known deficits.

the thought of the enhancement from that drug scares me

6:35 AM

I'm really at the top of the hierarchy in the nootropics space

6:36 AM

Some of the most influential individuals in our space all have opinions of me being a large focus of attention and with good reason

6:37 AM

Everyone is going to have DFO soon and really anyone can be like me

6:38 AM

It's the most liberating feeling i can imagine. I test things out on myself before givign people the go ahead

6:38 AM

I'd be patient 0 again

I will take the lead and be at the forefront on this one. (edited)

2

You'll give a great dose report. I am always concerned first with safety of everyone involved which is why im so diligent.

6:40 AM

We live in an incredibly cruel world dont we

I plan on it. I have yet to try INI as well and will give that a test soon.

6:40 AM

Cruel is a matter of perspective.

We wouldn't need these drugs if we weren't created in gods perfect image. We are going to become made in gods perfect image.

I plan on introducing an intranasal Rapamycin spray. I have tested solubilizers and at the moment it seems Diethylene Glycol Monoethly Ether is the prime candidate for solubilizing Rapamycin at a rate of 20.2mg/ml.

6:44 AM

DGME homogenized well with Caprylic Acid and was atomized from a standard nasal spray at a 1:1 ratio.

Thats really pushing humanity forward man

2

DGME is widely used in cosmetics as we speak. It will enhance penetration through the skin.

Nope. They will look at HbA1c levels and GAD antibodies and for type 2 diabetes insulin is not first line treatment. (edited)

No, and i would be cautious of your insurance as well

Original message was deleted or could not be loaded.

where r u from? i thought insulin is otc in most countries

insilico

where r u from? i thought insulin is otc in most countries

What country is it actually OTC?

Deleted User

What country is it actually OTC?

my country at least, morocco

11:45 AM

you can even get it for free if ur diabetic and applied for a welfare program

️

MC Ballyhoo

I will take the lead and be at the forefront on this one. (edited)

Oh shit

1:34 PM

Soldier

Original message was deleted or could not be loaded.

Find someone that's diabetic shouldn't be that hard

Deleted User

Oh shit

6:16 PM

I def got smarter on trial of hgh

https://www.sciencedirect.com/science/article/abs/pii/S0165032716316299?via%3Dihub https://academic.oup.com/jcem/article/98/10/E1626/2833510 https://www.bmj.com/content/284/6312/303

A randomized, double-blind, placebo-controlled, crossover trial eva...

Cognitive dysfunction in major depressive disorder (MDD) is identified as a primary therapeutic target; no current treatment is approved for the treat…

Intranasal Insulin Reduces Olfactory Sensitivity in Normosmic Humans

AbstractContext:. High densities of insulin receptors are found throughout the human brain, including the olfactory bulb, an essential brain area for odor proce

Insulin given intranasally induces hypoglycaemia in normal and diab...

Regular or crystalline insulin with sodium glycocholate as surfactant administered intranasally to normal volunteers induced hypoglycaemia and an increase in serum immunoreactive insulin concentrations. Serum C-peptide concentrations decreased or remained unchanged. Insulin administered intravenously to three of these subjects yielded a potency ...

veganprimate

https://www.sciencedirect.com/science/article/abs/pii/S0165032716316299?via%3Dihub https://academic.oup.com/jcem/article/98/10/E1626/2833510 https://www.bmj.com/content/284/6312/303

-3 blood glucose? It's over.

1

Pax1l

https://pubmed.ncbi.nlm.nih.gov/29508509/

A total of 38 studies in 1092 individuals receiving acute human intranasal insulin treatment and 18 studies in 832 individuals receiving human intranasal insulin treatment lasting between 21 days and 9.7 years were identified. No cases of symptomatic hypoglycaemia or severe adverse events (AEs) were reported. Transient local side effects in the nasal area were frequently experienced after intranasal insulin and placebo spray, while other AEs were less commonly reported.

@AERIN

1

Might get insulin to combine with my dihexa

7:22 AM

Also might practice breathing

In general I need to improve my relationship with insulin

Cast

In general I need to improve my relationship with insulin

i never feel insulin

11:42 AM

tried 20 and 40 IU

11:42 AM

not that id really expect to feel something special

11:42 AM

but at least.... something??

11:42 AM

which i havent felt whenever i used IN novorapid

Original message was deleted or could not be loaded.

Insulin is OTC?

It is in the us

INI is OP for me. Does that indicate my brain insulin sensitivity is good and I don't need it? Or should I try lowering dose?

No. Ini is fantastic and id recommend it to anyone

9:08 PM

I love that its overpowered for me

Pax1l

I love that its overpowered for me

I don't mean in a good way. Brain feels tense. Also have slight fatigue... Like i'm wired but tired. Gonna try again at 10 IU in a few days. (edited)

Deleted User

I don't mean in a good way. Brain feels tense. Also have slight fatigue... Like i'm wired but tired. Gonna try again at 10 IU in a few days. (edited)

how much did you take before?

9:27 PM

Never went above 20 IU

9:29 PM

It's also given me insomnia before

Would cardio, fasting and berberine be enough to keep insulin sensitivity under wraps?

10:02 PM

While using 40IU daily

It's leveled out now after eating, but had some moderate irritability initially. Snapped at my dad couple times.

10:54 PM

Probs just transient hypoglycemia

JoBro

Would cardio, fasting and berberine be enough to keep insulin sensitivity under wraps?

Yes

11:02 PM

There should be no concern of insulin resistance with intranasal insulin

11:04 PM

Theres no observed adverse events reported for intranasal insulin use in healthy subjects. It will greatly increase insulin sensitivity in diabetes and should be monitored

11:05 PM

Its an amazing wonder to learn about hypothalamic control of metabolic homeostasis. It just tied everything together.

11:06 PM

Typing speed with a cell phone is amazing with deferoxamine.

I don't think my body has a good relationship to insulin

10:24 PM

I almost always get tired after eating

10:05 AM

I think fixing my circadian rhythm will help

Cast

I think fixing my circadian rhythm will help

>cas 1380548-06-2

Cast

I think fixing my circadian rhythm will help

Sr9009 and melatonin bigbrain

Deleted User

Sr9009 and melatonin bigbrain

@Cast What this guy said (edited)

I have used the most potent icariin standardized content from horny goat weed extract. I think science bio was selling icariin powder a while ago. https://pubmed.ncbi.nlm.nih.gov/35799540/

Icariin ameliorates memory deficits through regulating brain insuli...

Icariin, a major prenylated flavonoid found in Epimedium spp., is a bioactive constituent of Herba Epimedii and has been shown to exert neuroprotective effects in experimental models of Alzheimer's disease. In this study, we investigated the neuroprotective mechanism of icariin in an APP/PS1/Tau tri …

Deleted User

I have used the most potent icariin standardized content from horny goat weed extract. I think science bio was selling icariin powder a while ago. https://pubmed.ncbi.nlm.nih.gov/35799540/

Promising, note though that it's rats, and rats with alzheimers disease, so may or may not apply to healthy-ish people. Fwiw I think HGW is win

Has anyone found a way to buy novolog otc in the US? Novolog should be better for our purposes than Novalin-R, although both are beneficial.

Original message was deleted or could not be loaded.

A did something like that for testosterone, took estradiol and did testosterone test, prescription on my hand

Original message was deleted or could not be loaded.

Dont do that

You know discord tos

Deleted User

What country is it actually OTC?

Here

5:36 AM

Almost 70% meds are free of prescription except narcotics and benzos

5:37 AM

Statins, anti diabetics, bp, isotretinoin etc

5:37 AM

A vial of injectable insulin costs 9.5$

Machine(The Neuron Feeder) 🤖

Almost 70% meds are free of prescription except narcotics and benzos

Yeah that's a third world country thing

Since starting intranasal insulin about 2 months ago, I've lost a considerable amount of weight considering I was already extremely skinny, to the point where my family has started to become concerned about my wellbeing.

2

2:03 PM

This is not a necessarily a negative

What's your BMI?

Yeah i spent probably 8 full months on in insulin and it was such a powerful stim when i first began it

6' 2" at 150lb with a large frame. Not underweight

Oh lol

Thats like a bmi of 17 i think

I'm 6'3 at 140lbs. You're good XD

Well theyre at 18.7

2:07 PM

I was never at that point but approaching a bmi of 20 is really on the edge of what people think is unnaturally skinny

2:09 PM

I dieted down from 160 and got questions when i hit 140 why i did it and they all said that well you were already skinny

2:10 PM

Its.definitely something people pay attention to

2:11 PM

You have to eat more jobro

Jobro needs more sweet potato and gherkins

No.. i subsided on fast food for 17 months and am actually a bit skinnier than when i began

2:14 PM

Sweet potatoes have about a calorie per gram

2:15 PM

Eating 1.6kg worth of sweet potatoes would put you at 1600 cal

2:15 PM

Potatoes have a bit more

Pax1l

Eating 1.6kg worth of sweet potatoes would put you at 1600 cal

I could eat 4k cal for a few months and barely put on any jelly fats. I always like cold exposure while in a fasted state and snorting rapamycin immediately afterwards then running as fast as i can into the nature trails for a couple hours and then eating strictly rice diet and then doing meditation and wim hof breathing

Im a bif incredulous

Deleted User

I could eat 4k cal for a few months and barely put on any jelly fats. I always like cold exposure while in a fasted state and snorting rapamycin immediately afterwards then running as fast as i can into the nature trails for a couple hours and then eating strictly rice diet and then doing meditation and wim hof breathing

Nice vlog joe rogan

Pax1l

Im a bif incredulous

Sorry i wish it were all true but actually its more than half true

People plagiarized your first dfo dose report and said i wrote it to make me sound insane

Lol hhhaaaaa

2:20 PM

Hhahaha

The brain spasm stuff is bordering schizo fuel

Bahahahhahap

I thought thaf becoming a fictional character and believing that im god was peak but no they thought your report was more worthy to make me sound insane

Pax1l

I thought thaf becoming a fictional character and believing that im god was peak but no they thought your report was more worthy to make me sound insane

Its like they are bunch of high school students, and you are the teacher. They just come to view your school of knowledge and throw balled up paper and stick gum underneath your desk and troll your works. You have the upper hand of maturity✈️ authority

️ dignity

and credibility

gratitude is expressed solemnly for your hierarchic⏲️ (edited)

Honestly i look forward to having everything out of my way. Now we can begin working on greater pursuits

Now we proceed incognito towards our projects and collection of knowledge/data for how 4chan is damned with unethical individuals

Taught a few some valuble lessons in the cokmunity

Pax1l

Taught a few some valuble lessons in the cokmunity

What is the most excessive daily rapamycin binge you have gone through? Or did u only do it 2x a week.

150mg in a day

Pax1l

150mg in a day

Is it a good idea for me to do 20mg intranasal every 4 days

yes

Okay. I want to try 100mg one day, but i fear days long hypertension and headache

why on earth would that happen

Hypertension seems to be prevalent for some ppl taking rapamycin, idk i seem to get it slightly. But i wonder How could i potentiate rapamycin to its full potential. I guess fasting, mapk activators, rice diet, and cold exposure and exercise ey and insulin (edited)

Mapk activation isn't something I'd recommend

3:05 PM

Honestly you're someone that shouldn't be concerned about blood pressure

Yeah my blood pressure has been really good for the past couple years. I think i was experiencing some headaches day after rapa idk maybe not

3:07 PM

Leaf said he prefers oral dosing to avoid brain hypertension

All the data we have on the safety of rapamycin is in organ transplant patients who may often be on a cocktail of various drugs

3:07 PM

Leaf is talking through his rear

Pax1l

All the data we have on the safety of rapamycin is in organ transplant patients who may often be on a cocktail of various drugs

Intranasal should limit systematic exposure below 10% amirite? So intranasal should be a lot more safe when it comes to immunodepression side effects

yes thats the idea

3:09 PM

it limits systemic exposure to about 4% of oral dosing

3:10 PM

noone really has looked through the data on intranasal use if they're going strictly by the data they have from people who have organ transplants

3:10 PM

I have gotten unnaturally angry because of how lazy they can be

3:11 PM

Rapamycin is given to people who need kidney transplants

3:12 PM

How on earth do I expect to think that the pharmacokinetics of rapamycin metabolism would not be substantially different on top of people who suffer from literal organ failure

3:13 PM

God damn and its often dosed alongside calcineurin inhibitors.

Pax1l

How on earth do I expect to think that the pharmacokinetics of rapamycin metabolism would not be substantially different on top of people who suffer from literal organ failure

We need J Fine to present the Rapamycin + Deferoxamine-ferritin-pore-unfolding-peptide relationship

I've gotten data like this about its effect on kidneys from people who later go on to say that Rapamycin is the greatest drug they've ever used

Pax1l

I've gotten data like this about its effect on kidneys from people who later go on to say that Rapamycin is the greatest drug they've ever used

Agreed. Someone said they can sleep for 3 hours and feel normal and functional and energetic and clear. I love rapamycin and i can’t wait to buy another gram next group buy soon (edited)

3:17 PM

I am going to put some rapa powder in my eyes rn

Deleted User

We need J Fine to present the Rapamycin + Deferoxamine-ferritin-pore-unfolding-peptide relationship

I don't think J Fine would be happy to hear correspondence from someone who's eager to bring up the use of exotic drugs alongside dfo and even then thats not including the ferritin pore unfolding peptide is ridiculously OP and safe to say that I do not believe that its possible at this point of time to make dfo conjugates with the ferritin pore unfolding peptide

Deleted User

I am going to put some rapa powder in my eyes rn

how about don't put drugs in your eyes

Pax1l

I don't think J Fine would be happy to hear correspondence from someone who's eager to bring up the use of exotic drugs alongside dfo and even then thats not including the ferritin pore unfolding peptide is ridiculously OP and safe to say that I do not believe that its possible at this point of time to make dfo conjugates with the ferritin pore unfolding peptide

I bet he would be interested in doing eloquent studies on dfo conjugates. Honestly dfo-ha simultaneous nanoemulsion would be good enough. And rad16-ikvav intranasal at 2mg daily in morning would be OP

BrothermanBill you're always the first to mention making some exotic conjugate with little rhyme or reason when you don't have the money to put into projects

3:21 PM

Give me money and then we can talk about me putting my lifes savings into projects

Pax1l

BrothermanBill you're always the first to mention making some exotic conjugate with little rhyme or reason when you don't have the money to put into projects

I havent found too much interest except for contributing $200-300 for something like from youngshe that would last me a long time

3:22 PM

I need to research rad16-ikvav

I need something more substantial and If you want to be invested in the success of the work involved then you have to contribute

Pax1l

I need something more substantial and If you want to be invested in the success of the work involved then you have to contribute

Do u have good connections with conjugation labs

yes I'm sure that wouldn't be too difficult

3:24 PM

Brotherman bill unless you have over $1000 I do not want to hear another project proposal from you

3:25 PM

The same goes for anyone, besides utility as reading material small molecule drug synths are expensive

Pax1l

Brotherman bill unless you have over $1000 I do not want to hear another project proposal from you

No im scared im going to lose it for an inactive dust of matter

Deleted User

No im scared im going to lose it for an inactive dust of matter

I've put $13k down in the past year for projects

Did u lose money contributing to D21

Its time you realize how the sausage is made

Deleted User

Did u lose money contributing to D21

D21 is still in development

Pax1l

D21 is still in development

Me and you are going to do it at the same exact time

Been thinking about this for a little bit but does anyone know if there's a potent insulin mimic ? I know there's a couple herbs that can cause glucose uptake but wondering if anyone developing/ed one that's more effective/potent

TreeSlayer

Been thinking about this for a little bit but does anyone know if there's a potent insulin mimic ? I know there's a couple herbs that can cause glucose uptake but wondering if anyone developing/ed one that's more effective/potent

Ceylon + berberine + chromium + pterostilbene + NAC

Deleted User

Ceylon + berberine + chromium + pterostilbene + NAC

Yes but not really what I meant, meant more of a single compound and one that's synthetic.

TreeSlayer

Been thinking about this for a little bit but does anyone know if there's a potent insulin mimic ? I know there's a couple herbs that can cause glucose uptake but wondering if anyone developing/ed one that's more effective/potent

Im looking at a PTP1B inhibitor called claramine. Its $675 for 160mg

Pax1l

I've put $13k down in the past year for projects

Can we please do smaller projects first but we will still get a big supply. Like i really want PQQ Methyl Esters. And Octreotide-HA. Yamsayn?

I know there's on going research for oral insulin but wondering if forgoing insulin for another compound that can achieve the same effects

Pax1l

Im looking at a PTP1B inhibitor called claramine. Its $675 for 160mg

I'll take a look

Deleted User

Can we please do smaller projects first but we will still get a big supply. Like i really want PQQ Methyl Esters. And Octreotide-HA. Yamsayn?

No there really is no such thing as a "smaller" project

TreeSlayer

I'll take a look

Its a positive allosteric modulator of insulin and tkrb signalling

3:32 PM

Promotes recycling of insulin receptors to the cell surface.

Pax1l

No there really is no such thing as a "smaller" project

Maybe you need to search for more quotes on synthesis requests that don’t cost more than 2 thousand (edited)

Deleted User

Maybe you need to search for more quotes on synthesis requests that don’t cost more than 2 thousand (edited)

There aren't any

3:33 PM

Do you have any idea how much things cost

Pax1l

Do you have any idea how much things cost

Yeah. I seen multiple synthesis projects only costs in a thousand or less to be done from chinese labs

for what

3:34 PM

because Im not going to supply you with drugs for free

Tropisetron, N-acetyl-l-tryptophan, research chem drugs, youngshe peptides, etc

If you want to be a choosing beggar then you're entitled to go to gintrux but I'm not going to put hours of work in or ask the same from my acquaintances to make something tailored for your wishes and not breaking even

3:36 PM

My time costs money

Deleted User

Tropisetron, N-acetyl-l-tryptophan, research chem drugs, youngshe peptides, etc

Ubiquitous drug, compound made by an eastern european chemist, simple compound, ubiquitous peptides

Pax1l

My time costs money

Thats why we should just go with youngshe peptides and i know a few conjugation labs that we can contact for our peptides. Best way and quickest and most cost effective

Deleted User

Thats why we should just go with youngshe peptides and i know a few conjugation labs that we can contact for our peptides. Best way and quickest and most cost effective

Who do you think is my fucking supplier?

3:39 PM

I just finished a synth

Pax1l

I just finished a synth

But u wont sell it to us!!!! Whyyyyy

@Mnemonic Entity

3:40 PM

Spam his inbox till he replies

3:41 PM

I can't help that the person that handles it doesn't have a decent handle on their own health or the health of their relatives

3:43 PM

If you want something new put up the money for it or stop asking me @Deleted User

3:44 PM

You owe me a lot more than your gratitude for affording you the insight and good health that deferoxamine and rapamycin has given you

Pax1l

If you want something new put up the money for it or stop asking me @Deleted User

But you never tell us when you are doing synths or reach out to the community about group buys. Gain a following on compounds that would the attention of several contributors. Or else i can just organize the group buy with another squad.

Deleted User

But you never tell us when you are doing synths or reach out to the community about group buys. Gain a following on compounds that would the attention of several contributors. Or else i can just organize the group buy with another squad.

Or else i can just organize the group buy with another squad.

3:46 PM

Really the whole reason why I will never disclose much of anything about the compounds that I synthesize

3:47 PM

I put the money in and I make sure that I have the product on hand before I ever think of asking for peoples money

3:48 PM

I have the principle of not fucking people over or having financial obligations and accountability for incompetence by a lab

3:48 PM

If you want to be invested in my success then you will contribute to my work financially or you may as well be stealing from me

3:50 PM

Im a researcher that puts my own money into projects to send a message

3:50 PM

I know what im getting involved in

Pax1l

If you want to be invested in my success then you will contribute to my work financially or you may as well be stealing from me

That would mostly be necessary for rare occasion where it is a special compound that is difficult to synthesize and/or conjugate. I wouldn’t know if it was going to gain enough attention if no one knew about it before i contributed, thus potentially screwing myself over

I have put in hundreds of hours of study to bring you education without asking for much in return but if you want something made then do not mention cutting me out of being your middle man because you want some fucking drugs

Deleted User

That would mostly be necessary for rare occasion where it is a special compound that is difficult to synthesize and/or conjugate. I wouldn’t know if it was going to gain enough attention if no one knew about it before i contributed, thus potentially screwing myself over

Everything is special, everything is complicated, nothing is cheap

3:52 PM

Labor isnt free

3:52 PM

Time isn't cheap

3:53 PM

Competency isn't cheap

There wouldn’t really be need for me to contribute thousands right now. When my contribution of a couple to a few hundred would suffice and as for anyone pitching in to meet the total minimum price quote

Deleted User

There wouldn’t really be need for me to contribute thousands right now. When my contribution of a couple to a few hundred would suffice and as for anyone pitching in to meet the total minimum price quote

Im not selling you drugs at cost

Pax1l

Im not selling you drugs at cost

Taxing too hard

i need money to survive

3:54 PM

how fucking hard is that to understand

3:54 PM

You might as well be pissing on my feet

Easy for me when i can just go elsewhere and organize a group buy for full fairness between everyone

GTFO

I don't organize a fucking charity and I don't ask for much out of anyone but If you want to be a part of my success then when organizing projects me and everyone that I work with are going to want money for our time and expertise and that goes for @everyone

I love you pax

If anyone wants to be like BrothermanBill and not pay me what my time and expertise are worth it's an insult

4:04 PM

I provide all this information freely with the expectation that I'd be given at least that standard of respect

4:05 PM

I'm entitled to make money from the research I do and introducing new compounds to the community I'm not going to sacrifice my life and wellbeing for someone that can say I can easily just cut you out entirely

4:06 PM

Noone I work should be treated to that standard

4:08 PM

When I make a compound I have the expectation minimum set that the person that does work for me to help organize projects and make sure things are handled well is treated as my employee and their labor is worth half of what profit I do make

3

4:09 PM

To put it into perspective I will need to sell 80 aliquots of cb3 to break even

4:09 PM

at $100

4:10 PM

my business partner keeps 50% for labor cost

4:11 PM

Cb3 is available now message mnemonic entity if you want to purchase some

Pax1l

I'm entitled to make money from the research I do and introducing new compounds to the community I'm not going to sacrifice my life and wellbeing for someone that can say I can easily just cut you out entirely

It's a real feeling.

Being treated that way is like telling me that I have no value

4:36 PM

If I'm not entitled to make money from this then I feel insulted.

4:37 PM

Thank you man

Being too cheap can certainly be toxic

Just dosed with some intranasal rapamycin and I forgot how amazing it can be sometimes

Auri

Being too cheap can certainly be toxic

Some people think they're more entitled to your own time than you and I've heard it far too many times

TreeSlayer

I know there's on going research for oral insulin but wondering if forgoing insulin for another compound that can achieve the same effects

Intranasal IGF-2 essentially

Pax1l

I don't organize a fucking charity and I don't ask for much out of anyone but If you want to be a part of my success then when organizing projects me and everyone that I work with are going to want money for our time and expertise and that goes for @everyone

I will contribute once I start earning good

5:11 PM

It will take some months but I will be helping soon

5:11 PM

5:12 PM

One of my friend whom I started working with will send me money for laptop soon so that I can code more

5:13 PM

It's matter of time before my life changes

5:13 PM

Sell me on cb3@Pax1l

Blossoming Tree of Peace

Sell me on cb3@Pax1l

later

Oki

Pax1l

GTFO

Maestus

Click to see attachment 🖼️

Nothing felt more insulting than having to make that point known

To say the least…

https://pubmed.ncbi.nlm.nih.gov/21738722/

Insulin promotes glycogen storage and cell proliferation in primary...

This study demonstrated that human astrocytes are insulin-responsive at the molecular level. We identified glycogen synthesis and cell proliferation as biological responses of insulin signaling in these brain cells. Hence, this cell type may contribute to the effects of insulin in the human brain.

So would intranasal IGF reduce growth hormone? Doesn’t GH cause certain types of growth on its own independent of its ability to cause IGF secretion? Is that bad?

12:15 AM

I’ve been trying to read into IGF system but my understanding is still pretty messy

Netizenne

So would intranasal IGF reduce growth hormone? Doesn’t GH cause certain types of growth on its own independent of its ability to cause IGF secretion? Is that bad?

Intranasal igf1 would reduce gh i believe as igf1 has negating effects on gh secretion but i wouldnt recommend intranasal igf1 administration. Im looking at igf1 inhibitors and sst analogues to reduce igf1 activity

https://doctorlib.info/medical/biochemistry/41.html I’m reading through this rn to review different endocrine axes

Biochemical Endocrinology - Medical Biochemistry

Biochemical Endocrinology - Medical Biochemistry - gives access to all of the latest information on basic and clinically focused genetic and molecular biology

1

1:22 AM

Always good to revisit the basics a bit!

6:12 PM

@Pax1l

Im so incredibly distraught over your condition and the likely consequences of the intranasal insulin use is reflective of AD pathophysiology. In this condition intranasal insulin cant help and possibly insulin accumulates in the cytosol due to tau hyperphosphorylation causing neuronal swelling and the formation of insulin aggregates called hexamers.

6:28 PM

Im so incredibly sorry that your condition has gone this far and idk if you could trust my advice again or accept anything that i could give you as a consolation.

6:30 PM

Once my latest project arrives in the US i will ask to have some sent to you

6:32 PM

There are many times in recent days where i feel like the worst person and being unable to help makes me feel awful

@Meso are you a chronic user?

7:51 PM

Of insulin

7:52 PM

Perhaps you might have devloped cerebral insulin resistance

7:53 PM

Or maybe your dose was too high it caused cerebral hypoglycemia causing neuron death or maybe something else

Machine(The Neuron Feeder) 🤖

@Meso are you a chronic user?

No he has had severe covid

Pax1l

No he has had severe covid

Ohh

Pax1l

There are many times in recent days where i feel like the worst person and being unable to help makes me feel awful

You are doing your best to the best of your knowledge. This compassion is already enough even if some people get worse on your suggestions. I'll stop intranasal insulin but will keep trying DFO

Meso

You are doing your best to the best of your knowledge. This compassion is already enough even if some people get worse on your suggestions. I'll stop intranasal insulin but will keep trying DFO

https://sdnn70.com/en/case-studies-of-intranasal-administration-of-c-peptide-to-persons-with-brain-damage-2/

Proinsulin C-peptide Research Team

Case studies of intranasal administration of C-peptide to persons w...

Gábor Varga and Márta Gadó PhD Abstract In the beginning of 2020 a team of special education teachers, speech-therapists, a psychologist and a health visitor conducted a pilot study in order to evaluate the experiences of clients using the intranasal C-peptide spray. Our study was based on two sources: video-recordings documenting the cases and ...

I only did 25 and 50 iu of insulin

The participants of our study used Vargapeptide skin-spray off label as an intranasal spray, on their own responsibility. The spray is produced and distributed by Max-Immun Ltd.

It was applied in the same way as the intranasal insulin, and administered among children with Phelan-McDermid syndrome. A 20 ml bottle contains a solution of 18 ml C-peptide. One puff of the spray contains 0.108 mg proinsulin C-peptid. In Vargapeptide 0.5 the corresponding amount is half of that, 0.05 mg, in Vargapeptide 2 the amount is 0.216 mg. The spray cointains 0.8 % NaCl. The other ingredients meet pharmaceutical grade purity standards. The purity of proinsulin C-peptid is 98-99%.

Three times over three days

Theres a product called vargapeptide

4:34 AM

Its a skin spray that was repurposed in this study to treat brain disorders

4:35 AM

Peptide c increases the insulin sensitivity and reduces insulin aggregate formation. It potentiates nitric oxide signalling and has neuroprotective effects that are non insulin dependant as well

4:36 AM

https://pubmed.ncbi.nlm.nih.gov/12951645/

C-peptide enhances insulin-mediated cell growth and protection agai...

C-peptide in the presence of insulin exerts synergistic effects on cell proliferation, neurite outgrowth and has in the presence of insulin an antiapoptotic effect on high glucose-induced apoptosis but less so on hyperosmolar-induced apoptosis. These effects are likely to be mediated via interaction …

I don't like iNOS and eNOS

Its been given in long term studies to type one diabetics subq and promoted an 80% improvement in neuropathy and nephrppathy.

Pax1l

https://sdnn70.com/en/case-studies-of-intranasal-administration-of-c-peptide-to-persons-with-brain-damage-2/

In this study its been used to treat patients with traumatic brain injuries, schizophrenia and autism over a long term period of months

I just need to upregulate tyrosine hydroxylase enzyme and dopamine receptors density permanently by using Bromantane, Forskolin and 9-me-bc

4:39 AM

My main problem is extreme anhedonia

Meso

My main problem is extreme anhedonia

Ive been having it rough at home and its been challenging

4:41 AM

Ive been using a lung trainer called "lung boost" and training my diaphram by breathing as hard as possible or for endurance

4:42 AM

Ive been progressing from 15 breaths in the morning to 30 and its greatly helped with my wnergy throughout the day

4:42 AM

Inspiratory muscle training has some compelling data behind it.

4:43 AM

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8955729/

Respiratory Muscle Training Can Improve Cognition, Lung Function, a...

Patients with chronic obstructive pulmonary disease (COPD) are frequently comorbid with mild cognitive impairment (MCI). Whether respiratory muscle training (RMT) is helpful for patients with COPD comorbid MCI remains unclear. Inspiratory muscle training ...

4:44 AM

This is the device i use

I'll also use SR9011 for microglial deactivation and improvement of refreshing quality of sleep that is linked to improved glymphatic clearance

It would definitely help benefit your lung function and promote recovery of your blood pressure and promote recovery of cognition

4:46 AM

You might not be able to exercise but this has helped me greatly

4:47 AM

I use a mendi neurofeedback trainer afterwards so that i can train my attention. I havent been consistent when i firsr bought it but now i use it a couple times a day

My symptoms are extreme due to long covid neurotoxicity and inflammation The microglia become activated erratically and cause even worse neurotoxicity by raising tonic glutamate level The cytokines storms potently inhibit dopamine receptors more potently than typical antipsychotics. GABA signalling is greatly suppressed as well

4:51 AM

PEA + Rasagiline offered me anhedonia and fatigue relief but I can no longer use it due to heart condition

Yes im familiar.

I need powerful peptides and research compounds

Ill share some data on my latest project soon. It shoild be ready

4:53 AM

Yes soluble app alpha is probably as powerful as it gets

4:54 AM

I am anticipating a 1nanogram starting dose

4:54 AM

4mg inadvertantly might give 4mil doses

4:56 AM

Soluble app alpha completely eliminates amyloid beta induced cognitive dysfunction and is tested in other models of neurotoxicity and greatly suppresses tau hyperphosphorylation through suppressing gsk3b activation

4:57 AM

https://discord.com/channels/1001420842179239936/1001422942380511286/1027072699345932438

4:57 AM

I made a review in the bio tolerance server

4:58 AM

A small one

What about microglial activation and neuroinflammation caused by LPS?

5:00 AM

And cytokines storms

Yes it suppresses that as well in the brain

5:01 AM

https://www.amazon.com/Bas-Rutten-Official-Respirator-Breathing/dp/B00CXS7B04/ref=asc_df_B00CXS7B04/?tag=hyprod-20&linkCode=df0&hvadid=167151490542&hvpos=&hvnetw=g&hvrand=13322199748200245295&hvpone=&hvptwo=&hvqmt=&hvdev=m&hvdvcmdl=&hvlocint=&hvlocphy=9017341&hvtargid=pla-315227952473&psc=1

Bas Rutten O2 Trainer - Official Workout Device for Respiratory Tra...

Bas Rutten O2 Trainer - Official Workout Device for Respiratory Training and Lung Muscle Fitness - Portable Breathing Mouthpiece for High Altitude and Power Training (Green)

What about the enhancement of glymphatic system waste clearance during refreshing sleep?

5:01 AM

Review for bas ruttens lung training device

Meso

What about the enhancement of glymphatic system waste clearance during refreshing sleep?

Any data on this?

5:02 AM

Because the compound I have shared does all of this

5:03 AM

And I can only buy one of them and not the other

Meso

What about the enhancement of glymphatic system waste clearance during refreshing sleep?

Im going to review the data on sappa within the coming days and make a writeup

Splendid

Close to bed time for me so i cant mention much more

Thanks for today

Meso

My symptoms are extreme due to long covid neurotoxicity and inflammation The microglia become activated erratically and cause even worse neurotoxicity by raising tonic glutamate level The cytokines storms potently inhibit dopamine receptors more potently than typical antipsychotics. GABA signalling is greatly suppressed as well

Try IN Cerebrolysin, greatly helped my post-COVID cognition, had COVID three times.

Meso

My symptoms are extreme due to long covid neurotoxicity and inflammation The microglia become activated erratically and cause even worse neurotoxicity by raising tonic glutamate level The cytokines storms potently inhibit dopamine receptors more potently than typical antipsychotics. GABA signalling is greatly suppressed as well

Anything that helped you at all?

JK

Anything that helped you at all?

Just the PEA + MAO-B inhibitor. Nothing else helped. Intramuscular injections of 5 ml Cerebrolysin daily doesn't seem to work at all.

1

8:09 PM

I'm seriously considering intranasal use

Meso

I'm seriously considering intranasal use

Me too, I’ll do a cycle of IN next starting 2023 (edited)

Hey @Pax1l , thoughts on this study? https://jamanetwork.com/journals/jamaneurology/fullarticle/2767376

Intranasal Insulin for the Treatment of Mild Cognitive Impairment a...

This randomized clinical trial examines the safety, efficacy, and feasibility of intranasal insulin for the treatment of persons with mild cognitive impairment and Alzheimer disease dementia.

Anyone think of IN hgh or try IN testosterone

@Pax1l would intranasal metformin be possible?

9:25 PM

Increase the number of insulin receptors possibly?

If it doesn't hurt your nasal epithelium

Soma

Increase the number of insulin receptors possibly?

It should reverse age related cognitive decline somewhat

Pax1l

It should reverse age related cognitive decline somewhat

I see that's interesting I was debating on getting a prescription for it tbh

DocR

Anyone think of IN hgh or try IN testosterone

I've brought the idea up. It's very good for improving will to exercise

2

Soma

I see that's interesting I was debating on getting a prescription for it tbh

Oral metformin is good. I don't know about intranasal just yet

Soma

I see that's interesting I was debating on getting a prescription for it tbh

https://pubmed.ncbi.nlm.nih.gov/35395244/

Intranasal metformin treatment ameliorates cognitive functions via ...

The present study showed for the first time that intranasal metformin treatment improved the impaired cognitive functions through increasing insulin sensitivity in ICV-STZ-induced mice model of AD.

Pax1l

https://pubmed.ncbi.nlm.nih.gov/35395244/

Oh wow ty

Don't forget to pepper in some chitin in your nasal spray solutions

11:44 PM

Or is it Chitosan

11:44 PM

I forget the actual thing

Pax1l

I've brought the idea up. It's very good for improving will to exercise

Natesto is a known formulation of IN test, interestingly there is less natural test suppression via this ROA which makes it attractive to me

3:55 AM

although I’m not using yet

Mifepristone as an AMPK inducer and insulin sensitizer has been on my radar for years. I think it might have large effects on metabolic health due to its direct hypothalamic effects, rather than just any direct mitochondrial effects.

1:38 PM

Probably not the first choice for use by women, unless they can tolerate the particular side-effect with bleeding out an egg or whatever, I'm not up-to-date with the physiology of it