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desensitization

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    desensitization

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    https://en.m.wikipedia.org/wiki/Arrestin_beta_2
    Arrestin beta 2
    Beta-arrestin-2, also known as arrestin beta-2, is an intracellular protein that in humans is encoded by the ARRB2 gene. Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neu...
    Arrestin beta 2

  1. https://en.m.wikipedia.org/wiki/G_protein-coupled_receptor_kinase
    G protein-coupled receptor kinase
    G protein-coupled receptor kinases (GPCRKs, GRKs) are a family of protein kinases within the AGC (protein kinase A, protein kinase G, protein kinase C) group of kinases. Like all AGC kinases, GRKs use ATP to add phosphate to Serine and Threonine residues in specific locations of target proteins. In particular, GRKs phosphorylate intracellular do...
    G protein-coupled receptor kinase

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