Last updated: 2021-11-02
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Knit directory: proxyMR/
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These are the previous versions of the repository in which changes were made to the R Markdown (analysis/update_meeting_03_11_2021.Rmd) and HTML (docs/update_meeting_03_11_2021.html) files. If you've configured a remote Git repository (see ?wflow_git_remote), click on the hyperlinks in the table below to view the files as they were in that past version.
| File | Version | Author | Date | Message |
|---|---|---|---|---|
| Rmd | 658242d | Jenny Sjaarda | 2021-11-02 | wflow_publish("analysis/update_meeting_03_11_2021.Rmd") |
| Rmd | b9d496f | Jenny Sjaarda | 2021-11-02 | wflow_rename("analysis/update_meetings_03_11_2021.Rmd", "analysis/update_meeting_03_11_2021.Rmd") |
Decided to run MVMR as follows: \(Y_p \sim X_i + Y_i + X_p\), using instruments for \({X_i, Y_i, X_p}\). In this MR, the coefficient for \(X_i\) would represent the direct \(X_i \rightarrow Y_p\) causal effect and hopefully this would be close to zero in most cases. Running simply the \(Y_p \sim X_i\) MR (with only \(X_i\) instruments), would give you the \(X_i \rightarrow Y_p\) total effect. Then we can compare the direct and total effect results.
A summary of the MVMR results are below, filtered to only traits with abs(correlation) < 0.8, and then BF significant with \(X_i\).
The column corr_traits corresponds to the raw correlation between traits in the biobank. The columns IVW_meta_beta and IVW_meta_pval correspond to the meta-analyzed across sexes univariate results from the \(Y_p ~ X_i\) MR. The subsequent columns correspond to the MVMR MR results.
sessionInfo()R version 4.1.0 (2021-05-18)
Platform: x86_64-pc-linux-gnu (64-bit)
Running under: CentOS Linux 7 (Core)
Matrix products: default
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