Last updated: 2023-06-12

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Knit directory: Cardiotoxicity/

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File	Version	Author	Date	Message
Rmd	1ebf470	reneeisnowhere	2023-06-12	adding figure 1

Figure 1

Top2i drugs affect cardiomyocyte viability in a dose dependent manner.

A. Project Overview

knitr::include_graphics("output/Fig_summary1.png")

things to note about this image so far: Need to import into illustrator. Goal is to have colors changes on Drugs from sick purple and jaudice yellow, to a red tone and a blue tone for non-ACs. I also want to change to add a time line of treatment.

B. Example Dose response curves from 48 hour drug exposure. Lines are a log-logistic regression of the mean from quadriplicates at 8 seperate concentrations for each condition, except (trastuzmab)TRZ, which is 7 concentrations.

knitr::include_graphics('output/plan2plot.png')

knitr::include_graphics('individual-legenddark2.png')

sessionInfo()

R version 4.2.2 (2022-10-31 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)

Matrix products: default

locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
[1] workflowr_1.7.0

loaded via a namespace (and not attached):
 [1] Rcpp_1.0.10      highr_0.10       compiler_4.2.2   pillar_1.9.0    
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 [9] tools_4.2.2      getPass_0.2-2    digest_0.6.31    jsonlite_1.8.5  
[13] evaluate_0.21    lifecycle_1.0.3  tibble_3.2.1     pkgconfig_2.0.3 
[17] rlang_1.1.1      cli_3.6.1        rstudioapi_0.14  yaml_2.3.7      
[21] xfun_0.39        fastmap_1.1.1    httr_1.4.5       stringr_1.5.0   
[25] knitr_1.43       fs_1.6.2         vctrs_0.6.2      sass_0.4.6      
[29] rprojroot_2.0.3  glue_1.6.2       R6_2.5.1         processx_3.8.1  
[33] fansi_1.0.4      rmarkdown_2.22   callr_3.7.3      magrittr_2.0.3  
[37] whisker_0.4.1    ps_1.7.5         promises_1.2.0.1 htmltools_0.5.5 
[41] httpuv_1.6.11    utf8_1.2.3       stringi_1.7.12   cachem_1.0.8

Figure1

ERM

2023-06-12

Figure 1

A. Project Overview

B. Example Dose response curves from 48 hour drug exposure. Lines are a log-logistic regression of the mean from quadriplicates at 8 seperate concentrations for each condition, except (trastuzmab)TRZ, which is 7 concentrations.