Last updated: 2023-08-15

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Knit directory: Cardiotoxicity/

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<environment: R_GlobalEnv>
<environment: R_GlobalEnv>

Figure 7

Chromatin regulators that mediate breast cancer sensitivity to ACs are enriched amongst early TOP2i response genes

A. Heatmap of Chromatin regulator gene sets

n= 408 is the Supplemental of curated Chromatin regulators

n= 54 were designated Dox response chromatin regulators according to Seoane analysis

B. Log2 cpm of KAT6B

C. Log2 cpm of KDM4B


R version 4.3.1 (2023-06-16 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)

Matrix products: default


locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

time zone: America/Chicago
tzcode source: internal

attached base packages:
[1] grid      stats     graphics  grDevices utils     datasets  methods  
[8] base     

other attached packages:
 [1] ComplexHeatmap_2.16.0 broom_1.0.5           RColorBrewer_1.1-3   
 [4] ggsignif_0.6.4        cowplot_1.1.1         BiocGenerics_0.46.0  
 [7] tinytex_0.45          lubridate_1.9.2       forcats_1.0.0        
[10] stringr_1.5.0         dplyr_1.1.2           purrr_1.0.1          
[13] readr_2.1.4           tidyr_1.3.0           tibble_3.2.1         
[16] ggplot2_3.4.2         tidyverse_2.0.0       workflowr_1.7.0      

loaded via a namespace (and not attached):
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[10] magrittr_2.0.3      compiler_4.3.1      rlang_1.1.1        
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