Run1_analysis
ERM
20230118
Last updated: 2023-06-16
Checks: 7 0
Knit directory: Cardiotoxicity/
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Hello! I am first loading all the beautiful libraries I will need.
#library(Biobase)
library(edgeR)#
library(limma)#
library(RColorBrewer)
library(mixOmics)
#library(VennDiagram)
#library(HTSFilter)
library(gridExtra)#
library(reshape2)#
library(devtools)
library(AnnotationHub)
library(tidyverse)
library(scales)
library(biomaRt)#
library(Homo.sapiens)
library(cowplot)#
library(ggrepel)#
library(corrplot)
library(Hmisc)The next step is to load all the data I will be using. Currently, I am not posting the raw data, but I will release in the future.
This is how I retrieved the gene symbols.
###now we add genenames to the geneid###
geneid <- rownames(mymatrix) ### pulls the names we have in the counts file
genes <- select(Homo.sapiens, keys=geneid, columns=c("SYMBOL"),
keytype="ENTREZID")
genes <- genes[!duplicated(genes$ENTREZID),]
mymatrix$genes <- genesFiltering out low count genes
Filtering the genes that are lowly expressed using several methods.
First method, removing only those rows with zero counts across all samples.
#
# old.par <- par(mar = c(0, 0, 0, 0))
# par(old.par)
# boxplot(data =RNAseqreads, total~Sample, main = "Boxplots of total reads",xaxt = "n", xlab= "")
# x_axis_labels(labels = samplenames, every_nth = 1, adj=1, srt =90, cex =0.4)
# ggplot(RNAseqreads, x = Sample, y = total)+
# geom_boxplot()
table(rowSums(mymatrix$counts==0)==72)
FALSE TRUE
24931 3464 This filtering would leave 24931 genes and remove 3464, That is too many leftover genes!
So now to try something a little more stringent using the built in function from the edgeR package.
keep <- filterByExpr.DGEList(mymatrix, group = group)
filter_test <- mymatrix[keep, , keep.lib.sizes=FALSE]
dim(filter_test)[1] 14448 72This method effectively uses a cutoff off that leaves 14448 genes.
The cutoff is determined by keeping genes that have a count-per-million
(CPM) above 10, (the default minimum set) in 6 samples. A set is
determined using the design matrix.
For my design, I grouped my 72 samples into sets of 6, one set includes
each individual + a specific treatment + a specific time.
The beginning cutoff-standard in our lab is to start by using the rowMeans >0 cutoff on the log10 of cpm.
cpm <- cpm(mymatrix)
lcpm <- cpm(mymatrix, log=TRUE) ### for determining the basic cutoffs
dim(lcpm)[1] 28395 72L <- mean(mymatrix$samples$lib.size) * 1e-6
M <- median(mymatrix$samples$lib.size) * 1e-6
c(L, M)[1] 4.679061 4.494188filcpm_matrix <- subset(lcpm, (rowMeans(lcpm)>0))
write.csv(filcpm_matrix, "data/filtered_cpm_counts.csv")
dim(filcpm_matrix)[1] 14823 72##method 2 with rowMeans
row_means <- rowMeans(lcpm)
x <- mymatrix[row_means > 0,]
dim(x)[1] 14823 72write.csv(x$counts, "data/raw_counts.csv")
saveRDS(x,"data/filtermatrix_x.RDS")Both of the above methods leave 14823 genes from 28,395. I prefer the second method, which keeps the DGEList format of the data.
now I will produce the RIN x sample plots:###
Principal Component Analysis
PCA was done using code adopted from J. Blischak.
### Vehicle 
### Daunorubicin 
### Doxorubicin 
### Epirubicin 
### Mitoxantrone 
### Trastuzumab 
PCA of all 72 samples
Warning: `qplot()` was deprecated in ggplot2 3.4.0.
This warning is displayed once every 8 hours.
Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
generated.
samplenames indv drug time RIN group PC1
Da.1.3h MCW_RM_R_11_S72 1 Daunorubicin 3h 9.3 1 -17.765444
Do.1.3h MCW_RM_R_12_S1_ 1 Doxorubicin 3h 9.8 2 -11.202574
Ep.1.3h MCW_RM_R_13_S2_ 1 Epirubicin 3h 9.8 3 -11.766749
Mi.1.3h MCW_RM_R_14_S3_ 1 Mitoxantrone 3h 10 4 -10.195323
Tr.1.3h MCW_RM_R_15_S4_ 1 Trastuzumab 3h 9.6 5 -11.379858
Ve.1.3h MCW_RM_R_16_S5_ 1 Vehicle 3h 9.9 6 -12.968358
Da.1.24h MCW_RM_R_17_S6_ 1 Daunorubicin 24h 7.8 7 128.820343
Do.1.24h MCW_RM_R_18_S7_ 1 Doxorubicin 24h 8.7 8 124.166408
Ep.1.24h MCW_RM_R_19_S8_ 1 Epirubicin 24h 8.6 9 135.640719
Mi.1.24h MCW_RM_R_20_S9_ 1 Mitoxantrone 24h 9.1 10 32.041620
Tr.1.24h MCW_RM_R_21_S10 1 Trastuzumab 24h 9.4 11 -8.049112
Ve.1.24h MCW_RM_R_22_S11 1 Vehicle 24h 9.3 12 -10.436637
Da.2.3h MCW_RM_R_23_S12 2 Daunorubicin 3h 9.4 1 -53.481064
Do.2.3h MCW_RM_R_24_S13 2 Doxorubicin 3h 9.6 2 -52.043118
Ep.2.3h MCW_RM_R_25_S14 2 Epirubicin 3h 9.9 3 -50.290519
Mi.2.3h MCW_RM_R_26_S15 2 Mitoxantrone 3h 9.4 4 -45.778343
Tr.2.3h MCW_RM_R_27_S16 2 Trastuzumab 3h 9.9 5 -54.615700
Ve.2.3h MCW_RM_R_28_S17 2 Vehicle 3h 9.8 6 -54.638772
Da.2.24h MCW_RM_R_29_S18 2 Daunorubicin 24h 9.5 7 109.751183
Do.2.24h MCW_RM_R_30_S19 2 Doxorubicin 24h 9.9 8 124.757720
Ep.2.24h MCW_RM_R_31_S20 2 Epirubicin 24h 9.6 9 35.805995
Mi.2.24h MCW_RM_R_32_S21 2 Mitoxantrone 24h 9.9 10 -23.428010
Tr.2.24h MCW_RM_R_33_S22 2 Trastuzumab 24h 8.8 11 -55.296998
Ve.2.24h MCW_RM_R_34_S23 2 Vehicle 24h 9.5 12 -59.725622
Da.3.3h MCW_RM_R_35_S60 3 Daunorubicin 3h 9.3 1 -39.463382
Do.3.3h MCW_RM_R_36_S61 3 Doxorubicin 3h 10 2 -36.423003
Ep.3.3h MCW_RM_R_37_S62 3 Epirubicin 3h 9.3 3 -43.829150
Mi.3.3h MCW_RM_R_38_S63 3 Mitoxantrone 3h 9.6 4 -46.984783
Tr.3.3h MCW_RM_R_39_S64 3 Trastuzumab 3h 9.7 5 -44.136822
Ve.3.3h MCW_RM_R_40_S65 3 Vehicle 3h 9.4 6 -50.451226
Da.3.24h MCW_RM_R_41_S66 3 Daunorubicin 24h 8.9 7 103.551507
Do.3.24h MCW_RM_R_42_S67 3 Doxorubicin 24h 7.5 8 104.969328
Ep.3.24h MCW_RM_R_43_S68 3 Epirubicin 24h 8.6 9 126.124461
Mi.3.24h MCW_RM_R_44_S69 3 Mitoxantrone 24h 8.5 10 -6.025219
Tr.3.24h MCW_RM_R_45_S70 3 Trastuzumab 24h 8.6 11 -50.602582
Ve.3.24h MCW_RM_R_46_S71 3 Vehicle 24h 9.3 12 -57.442738
Da.4.3h MCW_RM_R_47_S24 4 Daunorubicin 3h 9.6 1 -24.642747
Do.4.3h MCW_RM_R_48_S25 4 Doxorubicin 3h 9.6 2 -29.652237
Ep.4.3h MCW_RM_R_49_S26 4 Epirubicin 3h 9.4 3 -25.828133
Mi.4.3h MCW_RM_R_50_S27 4 Mitoxantrone 3h 9.7 4 -26.335444
Tr.4.3h MCW_RM_R_51_S28 4 Trastuzumab 3h 9.9 5 -31.419485
Ve.4.3h MCW_RM_R_52_S29 4 Vehicle 3h 10 6 -27.332551
Da.4.24h MCW_RM_R_53_S30 4 Daunorubicin 24h 9.4 7 112.604406
Do.4.24h MCW_RM_R_54_S31 4 Doxorubicin 24h 9.6 8 115.313215
Ep.4.24h MCW_RM_R_55_S32 4 Epirubicin 24h 9.4 9 109.074167
Mi.4.24h MCW_RM_R_56_S33 4 Mitoxantrone 24h 9.5 10 7.800789
Tr.4.24h MCW_RM_R_57_S34 4 Trastuzumab 24h 9.8 11 -25.683016
Ve.4.24h MCW_RM_R_58_S35 4 Vehicle 24h 9.5 12 -24.441854
Da.5.3h MCW_RM_R_59_S36 5 Daunorubicin 3h 9.6 1 -24.095421
Do.5.3h MCW_RM_R_60_S37 5 Doxorubicin 3h 9.7 2 -24.681355
Ep.5.3h MCW_RM_R_61_S38 5 Epirubicin 3h 9.6 3 -30.042036
Mi.5.3h MCW_RM_R_62_S39 5 Mitoxantrone 3h 9.9 4 -33.753118
Tr.5.3h MCW_RM_R_63_S40 5 Trastuzumab 3h 9.6 5 -39.148605
Ve.5.3h MCW_RM_R_64_S41 5 Vehicle 3h 10 6 -36.285377
Da.5.24h MCW_RM_R_65_S42 5 Daunorubicin 24h 8.3 7 86.856529
Do.5.24h MCW_RM_R_66_S43 5 Doxorubicin 24h 8.4 8 84.801559
Ep.5.24h MCW_RM_R_67_S44 5 Epirubicin 24h 9.4 9 68.506877
Mi.5.24h MCW_RM_R_68_S45 5 Mitoxantrone 24h 9.7 10 10.876605
Tr.5.24h MCW_RM_R_69_S46 5 Trastuzumab 24h 10 11 -38.341977
Ve.5.24h MCW_RM_R_70_S47 5 Vehicle 24h 10 12 -36.723434
Da.6.3h MCW_RM_R_71_S48 6 Daunorubicin 3h 9.6 1 -36.819292
Do.6.3h MCW_RM_R_72_S49 6 Doxorubicin 3h 9.6 2 -42.140937
Ep.6.3h MCW_RM_R_73_S50 6 Epirubicin 3h 9.7 3 -41.905162
Mi.6.3h MCW_RM_R_74_S51 6 Mitoxantrone 3h 9.5 4 -41.631591
Tr.6.3h MCW_RM_R_75_S52 6 Trastuzumab 3h 9.8 5 -50.305589
Ve.6.3h MCW_RM_R_76_S53 6 Vehicle 3h 9.5 6 -47.776394
Da.6.24h MCW_RM_R_77_S54 6 Daunorubicin 24h 9.8 7 85.941150
Do.6.24h MCW_RM_R_78_S55 6 Doxorubicin 24h 8.6 8 31.704949
Ep.6.24h MCW_RM_R_79_S56 6 Epirubicin 24h 8.9 9 28.276419
Mi.6.24h MCW_RM_R_80_S57 6 Mitoxantrone 24h 9.1 10 -16.379467
Tr.6.24h MCW_RM_R_81_S58 6 Trastuzumab 24h 9.3 11 -46.582008
Ve.6.24h MCW_RM_R_82_S59 6 Vehicle 24h 9.6 12 -47.017614
PC2 PC3 PC4 PC5 PC6
Da.1.3h 59.803155 36.6204870 -4.408061 23.6161518 -5.333529e+00
Do.1.3h 70.217333 25.4300908 3.453687 -13.1709859 9.691970e+00
Ep.1.3h 63.934149 29.1918975 1.455258 18.3878393 6.419868e+00
Mi.1.3h 69.739950 21.4198120 9.760780 -3.2588182 1.216757e+01
Tr.1.3h 75.640180 10.0773652 15.076728 -23.6546581 2.444411e+01
Ve.1.3h 72.059774 16.9012499 1.738985 -29.3598282 2.093145e+01
Da.1.24h 37.982749 20.4443026 22.363106 -19.1353851 -4.261629e+00
Do.1.24h 54.358085 12.5657474 13.330841 -93.1649148 -1.611228e+02
Ep.1.24h 31.939240 2.7190498 30.224091 -14.7431542 9.239902e-03
Mi.1.24h 77.667109 -9.9367544 17.440604 -32.9303801 2.746417e+01
Tr.1.24h 78.636432 -7.6571513 35.953186 -31.9733513 2.474218e+01
Ve.1.24h 86.956682 3.0487228 23.641102 -35.7460584 2.154252e+01
Da.2.3h -58.420344 26.3099581 3.131308 -16.0308225 -1.341690e+01
Do.2.3h -63.386891 16.0174966 -3.447194 -45.7496426 -1.780337e-01
Ep.2.3h -55.430202 19.2809566 10.455535 -10.7880713 -8.939829e+00
Mi.2.3h -55.380503 11.7795564 24.705141 -21.4233153 -2.858599e+00
Tr.2.3h -72.878114 6.9500727 -5.177569 -42.3393927 6.901202e+00
Ve.2.3h -57.358703 -1.2907912 -5.574730 -54.8782904 9.990850e+00
Da.2.24h -63.324095 18.8320256 9.041480 -12.0059726 2.393033e+01
Do.2.24h -70.492118 50.5807231 38.819011 -26.4199147 3.824111e+01
Ep.2.24h -102.431325 188.2275586 46.915564 14.9790672 2.350990e+01
Mi.2.24h -49.365626 -27.9880407 -12.103052 -33.2861364 1.913401e+01
Tr.2.24h -61.104411 -13.2717216 1.755183 -33.1322088 3.804898e+00
Ve.2.24h -72.923900 -0.1887682 -23.633194 -37.2414983 -2.895573e-01
Da.3.3h -19.771168 5.7879408 11.644292 38.6244162 -3.466777e+01
Do.3.3h -7.093025 -8.3557636 5.361135 -5.2330387 -5.565143e+00
Ep.3.3h -19.065009 2.5390946 -1.328768 49.6411907 -3.315330e+01
Mi.3.3h -28.878170 2.6607314 -15.798121 41.0732591 -3.376924e+01
Tr.3.3h -12.956806 -20.6159968 -6.828197 -0.8822215 3.201939e+00
Ve.3.3h -24.351535 -22.3874154 -8.157205 24.6533264 -1.946887e+01
Da.3.24h -28.527857 -32.1179263 -18.805371 23.2024129 2.040424e+00
Do.3.24h -50.089721 -19.5172907 -57.546102 -2.6575862 2.003667e+00
Ep.3.24h -42.813291 -25.9847592 -7.022504 18.6773800 8.126547e+00
Mi.3.24h -14.847934 -38.4567094 -27.155922 -3.2361263 1.474846e+01
Tr.3.24h -21.334411 -22.3989795 -26.821547 -22.0880495 3.116563e+00
Ve.3.24h -29.586244 -15.8752889 -17.237007 -16.1107025 -3.715394e+00
Da.4.3h 51.666241 40.5428573 -13.532447 24.6481768 -4.326511e+00
Do.4.3h 41.756402 26.9585365 -29.293328 18.8970133 -2.111117e+00
Ep.4.3h 45.336105 32.3343864 -19.932580 21.5576571 -2.895039e+00
Mi.4.3h 39.606796 19.5337341 -16.990320 17.7648694 2.898490e+00
Tr.4.3h 44.020982 10.1999920 -16.543513 8.9882411 9.783041e+00
Ve.4.3h 52.443707 7.8177233 -2.225478 5.0960192 1.480487e+01
Da.4.24h 5.354493 10.0698175 -22.972096 23.4271020 2.474510e+00
Do.4.24h 15.844622 -0.8273635 -14.996158 15.9608197 3.907734e+00
Ep.4.24h 4.822611 15.3809870 -41.007048 30.8620612 8.980186e-01
Mi.4.24h 48.013635 -10.2502138 -24.985932 -1.8584684 2.224544e+01
Tr.4.24h 47.899093 -6.7429939 12.078328 3.7446134 1.202363e+01
Ve.4.24h 58.332857 -1.0785851 -1.372838 -8.1725518 1.421336e+01
Da.5.3h -7.637167 1.7857672 57.264252 52.7563853 -2.626017e+01
Do.5.3h 1.051621 -19.2403627 46.843220 21.6008080 -4.179021e+00
Ep.5.3h -11.453656 -15.4039857 52.859161 59.1892313 -2.206167e+01
Mi.5.3h -12.458482 -6.7996300 40.965990 43.5262726 -2.083383e+01
Tr.5.3h -13.939555 -34.8486990 45.285752 19.1570531 -9.943791e+00
Ve.5.3h -7.248475 -38.4184897 77.439717 6.9328094 2.800347e+00
Da.5.24h -29.519887 -41.8797131 52.204419 10.6883612 7.309301e+00
Do.5.24h -32.974639 -43.2891280 -2.935038 23.8816235 1.021210e+00
Ep.5.24h -10.919783 -60.6916133 25.578191 15.9763160 9.964628e+00
Mi.5.24h -1.114319 -50.9618253 30.041960 2.9561311 2.401802e+01
Tr.5.24h -10.926018 -41.1407451 55.793694 -4.3733834 4.747348e+00
Ve.5.24h -5.009730 -36.2866355 55.933819 -25.4117350 1.055652e+01
Da.6.3h -2.078555 27.0719751 -22.221822 22.9976940 -1.310154e+01
Do.6.3h 6.075180 6.3493410 -22.285620 4.9373274 -7.330110e+00
Ep.6.3h 9.115835 16.3445113 -32.286519 2.8241026 -5.208931e+00
Mi.6.3h 5.703649 17.0733719 -27.663197 15.2042322 -1.128098e+01
Tr.6.3h 3.695811 -1.6581284 -30.709656 9.0005689 -7.785362e+00
Ve.6.3h 12.924796 0.2833606 -24.321585 5.3360443 -4.887770e+00
Da.6.24h -15.774562 -19.1535756 -28.426345 12.7825559 5.288897e+00
Do.6.24h -17.374056 -21.2849762 -73.684211 6.7109748 7.609719e+00
Ep.6.24h -10.748385 -11.2741475 -66.801251 10.0361788 -1.906506e-01
Mi.6.24h -1.670330 -19.4299047 -52.426614 -10.5826490 7.637542e+00
Tr.6.24h -1.961474 -9.7722162 -24.599356 -33.3750570 2.268468e+00
Ve.6.24h 2.021203 -2.6549107 -25.298026 -5.8819183 -3.496990e+00
PC7 PC8 PC9 PC10 PC11
Da.1.3h 32.9639103 -1.86359963 21.4521708 -26.6757824 9.8932562
Do.1.3h 16.8694298 -5.34281345 10.9325418 -11.2483305 10.6913322
Ep.1.3h 38.3572614 -0.08094922 30.4077750 -15.4720244 -6.1807259
Mi.1.3h 23.2389700 -1.08085291 13.7230167 -12.3327335 9.7601857
Tr.1.3h 10.8457851 1.23793606 8.0838594 -13.6547291 9.1356193
Ve.1.3h 15.9289474 0.22931843 -0.6407972 -1.3429675 12.7762906
Da.1.24h -7.6547331 -15.23073323 -4.3352243 -44.1700657 -4.8029423
Do.1.24h -2.7919444 27.15191566 -2.5023324 29.4103666 2.6089379
Ep.1.24h -6.3151013 -12.06026079 18.0149088 -39.0926365 -16.8061256
Mi.1.24h 0.6993123 24.71918035 11.2386818 -12.5412472 35.2551125
Tr.1.24h -12.1258138 -0.52501316 14.4390006 -17.1872802 9.6652064
Ve.1.24h -18.3338957 -8.02346953 7.6670385 -11.1532847 19.1603340
Da.2.3h 35.6913015 -23.50411067 20.6132497 -14.0947587 -0.6651170
Do.2.3h 32.6148836 -21.15750073 -10.6183403 6.0416102 8.6230433
Ep.2.3h 47.1751347 -29.19580208 15.0289989 6.6185719 -0.8977218
Mi.2.3h 37.1622512 -20.07653196 1.1922454 -1.1499815 8.3495905
Tr.2.3h 49.8284805 -14.87917841 -3.3992794 10.2849870 -5.9416231
Ve.2.3h 13.6022411 -11.02126584 -6.6678045 8.6942338 -5.7588555
Da.2.24h -2.3206876 -26.01634523 -27.8064198 -17.7918600 9.8120531
Do.2.24h -36.7533538 -55.08584892 -44.6327102 7.4278703 20.2327691
Ep.2.24h -45.0389420 86.12745218 28.4864059 22.3795290 -1.0389823
Mi.2.24h 28.1404542 27.83870047 15.0852602 -0.7005199 20.3381819
Tr.2.24h 23.7881729 4.79213777 17.5858965 -15.7298123 -20.5265008
Ve.2.24h 28.9463872 12.47438247 -0.8372427 -16.9461121 -11.8335210
Da.3.3h -29.0421354 -27.55922341 16.0057909 -8.4568819 36.5865808
Do.3.3h -33.8033319 -34.15521137 17.9871052 25.8356525 23.9746160
Ep.3.3h -7.9532854 -15.20467582 33.9949087 -11.5062197 10.3711846
Mi.3.3h -13.2565817 -12.93534350 24.2359980 -9.9341608 23.7360331
Tr.3.3h -26.1191549 -22.61054313 25.6178165 38.4011304 6.2226569
Ve.3.3h -26.6511546 -5.55175578 17.9241667 1.1926311 11.7501412
Da.3.24h -0.7651877 -8.59931358 27.8260092 -9.0858066 9.2482057
Do.3.24h -28.3032828 -17.82712019 9.0717931 -2.9255217 16.0838142
Ep.3.24h -17.3519124 -35.01391572 24.6898169 -0.4599617 -5.6855723
Mi.3.24h -18.1122194 24.83726657 29.8887266 13.5100362 33.7528351
Tr.3.24h -39.3925259 -6.43531225 13.1631485 12.6208177 6.2616729
Ve.3.24h -40.6132780 -12.57878928 30.7400851 1.3173940 -28.6630193
Da.4.3h 6.7047717 -17.44465422 -3.6163330 18.0860502 -4.1162754
Do.4.3h 4.6589920 -10.96624263 -12.5297044 21.7152232 -5.4050482
Ep.4.3h 11.4350426 -10.97354857 -8.7114233 15.0704604 -7.1669826
Mi.4.3h 6.2654071 -8.37077929 -13.9807735 22.0756412 -3.4194396
Tr.4.3h 0.3446914 -9.15420889 -11.2160418 31.4777756 -14.0195200
Ve.4.3h 0.6826856 -13.54416653 -14.9710627 34.4489900 -9.5816761
Da.4.24h 22.3259965 -9.66240839 -3.5905812 13.2205080 -31.6887849
Do.4.24h 16.1817118 -15.33398197 3.9146008 27.8222718 -28.8099425
Ep.4.24h 27.8485286 0.05861697 8.8386714 8.6739200 -43.6245704
Mi.4.24h 5.8221534 20.09778494 11.4804063 33.1864966 6.4980189
Tr.4.24h -9.8206501 -9.40216040 5.5534237 21.3255636 -17.3423169
Ve.4.24h -26.8232527 -12.01005531 -7.7157322 24.3168847 -6.3726485
Da.5.3h -3.1919004 2.07387518 -12.6721315 -17.8172094 10.1004811
Do.5.3h -3.7857506 -2.41177425 5.3872216 11.2640552 -10.0689025
Ep.5.3h 21.9732799 3.40027599 -0.5608309 -6.0205355 -6.1449254
Mi.5.3h 16.3012378 8.12682732 -12.8712771 -8.4995034 6.9374840
Tr.5.3h 0.3480273 23.30141084 -21.4430982 -5.6162241 -8.0216157
Ve.5.3h 11.6213902 14.58820668 -41.8228491 26.3895769 2.7030386
Da.5.24h 12.2824367 10.35325199 -46.2356376 23.1372214 30.5694572
Do.5.24h 14.7134359 23.33875822 -1.9540116 -10.4527522 -4.7172469
Ep.5.24h 6.2366255 22.07914890 12.7324789 13.2169384 2.0349573
Mi.5.24h 13.5990679 42.17657768 13.0359382 13.0416029 2.1243468
Tr.5.24h -22.5669646 12.80012044 15.9929082 -13.6551866 -45.1382535
Ve.5.24h -29.3145543 10.31443530 -2.4520227 -4.0990486 -44.0444936
Da.6.3h 6.6355140 5.12969988 -27.6635087 -19.5318512 -0.5407346
Do.6.3h -17.0334105 4.52684378 -30.7304470 -24.6244664 -7.6276158
Ep.6.3h -14.3179220 0.09755169 -22.4996028 -14.2911604 -16.8501998
Mi.6.3h -5.2309411 3.19154314 -41.0123291 -17.6266041 6.8893286
Tr.6.3h -24.1571245 7.97158562 -33.8619719 -14.8549962 -7.7198450
Ve.6.3h -20.6436018 -0.77954824 -39.9511066 -10.6034074 1.5772196
Da.6.24h 8.2946407 10.36801812 -14.6530161 -10.0602474 1.3752115
Do.6.24h 17.0836885 41.35304197 2.3401062 7.4365231 -3.3098561
Ep.6.24h 12.3077009 33.31614935 -13.9735939 -7.3225397 14.2430841
Mi.6.24h -9.8881630 39.66525998 -19.1887705 -9.1492068 27.6077860
Tr.6.24h -59.6686078 10.22105678 3.4448530 -27.1450080 -36.6440083
Ve.6.24h -20.3785842 5.71067773 -26.4990155 -14.6179078 -5.7744573
PC12 PC13 PC14 PC15 PC16
Da.1.3h -3.16139300 13.9400262 -14.8627543 7.93154623 -15.1523450
Do.1.3h -16.56445886 15.1579441 -3.8982395 -8.52067913 -12.1550997
Ep.1.3h -1.28814893 22.7153951 -19.9575706 -3.01979028 -15.8876817
Mi.1.3h -5.39521282 13.4419282 -11.5536984 -9.94707414 -11.1591723
Tr.1.3h -10.46782293 8.7739164 -20.7889180 -12.33466066 -0.4429972
Ve.1.3h -18.52195559 6.0125974 -13.2119929 -21.57085329 -8.0573168
Da.1.24h -5.01658320 -47.7270065 35.3053380 -12.08477540 1.0277323
Do.1.24h 14.65426132 18.6707716 -11.4389503 2.32889041 -0.6318946
Ep.1.24h -1.67838064 -32.8220116 14.6875645 -18.08826851 5.9036584
Mi.1.24h 16.23260362 -15.6678195 21.9683645 6.22938801 -4.5607534
Tr.1.24h -2.32406480 -2.4785983 -13.1161711 3.30114100 12.6181010
Ve.1.24h -11.51740742 -3.7656231 -5.7899241 6.08760202 18.0816769
Da.2.3h -10.48112544 8.8781695 15.4368339 24.93994786 6.4222765
Do.2.3h -14.29371196 -6.0318289 22.8519324 -8.26188127 2.0822902
Ep.2.3h -5.79941363 5.7052044 18.0533247 10.35824097 -4.1062197
Mi.2.3h -4.04094867 -5.3410749 8.9544584 6.36731506 3.9625687
Tr.2.3h -5.54103888 -8.6999711 -2.2238044 -9.85223069 2.2223533
Ve.2.3h -10.38971755 -2.4835673 4.8322359 -18.47524552 9.3312895
Da.2.24h 36.66216750 16.2793973 -20.9110249 7.00878085 9.0088968
Do.2.24h 42.72123756 30.7401644 -2.2806354 6.01420897 -33.2792899
Ep.2.24h -16.78265020 -6.1898815 -4.2107481 -5.75132043 9.8366801
Mi.2.24h 31.78749372 -2.4093283 -1.3043641 12.94256729 -2.3104212
Tr.2.24h 15.01630272 -11.7081248 -18.2868542 9.30547091 5.4540038
Ve.2.24h 9.28188083 -22.9887543 -24.2565902 3.32163736 17.3053316
Da.3.3h -3.49081716 -20.6832266 14.8175924 18.74144345 -8.1393360
Do.3.3h -20.08969072 10.1178775 29.6798682 -20.74604709 1.2013465
Ep.3.3h 3.09658351 -11.2627292 -9.9514076 11.80961321 -20.5451576
Mi.3.3h 3.56403905 -18.3094991 -2.0295930 0.66098374 -12.3303506
Tr.3.3h -6.43344282 1.6663764 4.4841997 -30.82245559 -3.9938492
Ve.3.3h 7.25347632 -27.7287089 -22.8247140 -10.87203172 -9.0675889
Da.3.24h -7.34057101 15.8930479 -16.1153124 0.07822845 19.3262827
Do.3.24h -19.47978777 11.5208285 -19.7000396 -10.03018838 18.2460082
Ep.3.24h 1.87439190 14.5952886 -28.0680021 -7.23541693 1.5723725
Mi.3.24h 27.98366012 -1.2007610 4.2643019 1.47521390 -2.3694500
Tr.3.24h -2.15128507 -7.3925630 -1.7371441 -16.70704888 10.6217288
Ve.3.24h -11.51853973 0.8121197 -9.5901730 8.39429644 -16.3411417
Da.4.3h -0.64645941 9.2627351 7.2224848 24.47365232 7.4983658
Do.4.3h 0.73548588 1.4368008 1.7778272 6.76409969 3.8344309
Ep.4.3h 1.77812068 7.5001534 0.4703510 14.95818932 8.4089625
Mi.4.3h 10.63922128 -3.7827759 -1.6498401 1.50099813 6.1830941
Tr.4.3h 7.87906576 -6.0381691 -9.0084997 -0.65242879 3.3329833
Ve.4.3h 4.98371402 -2.5884975 -6.8786412 0.86559430 6.1765427
Da.4.24h 7.75703239 -23.7817720 13.7596668 -1.17309230 -10.4363401
Do.4.24h -4.44144625 -18.8018750 14.5557147 -1.02750987 -13.1838046
Ep.4.24h 11.41152111 -22.2045294 -4.8150847 -9.20878879 -2.4693192
Mi.4.24h 24.55965756 -14.6787373 13.2161755 14.69801623 -1.8064784
Tr.4.24h 11.61656390 -11.7234672 -11.7353470 18.78768399 12.7264255
Ve.4.24h 5.86201180 -13.4835749 -1.7793560 20.74591642 32.8891954
Da.5.3h 7.23458905 4.5399682 11.9861370 5.39834209 17.5252252
Do.5.3h -3.04930347 28.8405790 22.1992547 -26.30615916 15.8442486
Ep.5.3h 17.91086328 7.8719569 -5.2894245 -9.03871709 6.8025597
Mi.5.3h 12.65814325 0.7399895 9.0105585 -8.47970544 6.0236049
Tr.5.3h 14.42903212 -18.8869873 -16.3352236 -23.09238210 3.0045319
Ve.5.3h -16.55479394 -26.3400114 -24.4626345 -21.37840347 -34.9223202
Da.5.24h -64.35545920 -17.3195256 -19.7690136 40.07424918 -7.5445385
Do.5.24h -16.98533993 14.3379688 -6.9476568 3.62429485 27.6372152
Ep.5.24h -20.94789744 24.8022718 22.3787077 10.34025868 10.8196263
Mi.5.24h 40.30091817 20.3471497 21.5706454 -0.24748479 -12.9829618
Tr.5.24h 6.17170394 16.2875211 0.2477596 11.91449263 -1.1690593
Ve.5.24h -8.17359422 17.7400799 11.9705432 9.36552746 -8.4867526
Da.6.3h 0.13873092 17.9560746 5.4401408 -2.26822988 -1.9045504
Do.6.3h -2.42063500 14.3716335 6.1100131 -7.93740327 3.4593906
Ep.6.3h -9.28935424 25.5833193 12.4852310 -7.02364740 -5.0790385
Mi.6.3h 5.55359125 5.4771200 8.2495985 -9.87618306 7.2075808
Tr.6.3h 7.47364456 -4.3377491 -7.0380978 -11.28728602 4.1136161
Ve.6.3h 0.26696964 -0.5614478 -2.4082648 -7.89079250 9.8964011
Da.6.24h -13.38623789 8.3882746 14.4940828 5.57571246 -5.2807535
Do.6.24h -18.68073850 17.4627646 5.6493501 -12.20864196 -24.3680470
Ep.6.24h -14.60564780 1.0903728 6.5657099 0.42270571 -1.0455708
Mi.6.24h 15.59999383 -10.8831082 9.9753274 3.84141680 -3.8574655
Tr.6.24h -17.70291371 2.8739760 6.3173282 28.44828634 -26.8596601
Ve.6.24h -0.08068275 -11.5284578 -4.7629115 14.32087109 -5.6818717
PC17 PC18 PC19 PC20 PC21
Da.1.3h 6.1454597 -2.2493735 13.5808519 -6.90686175 4.8111848
Do.1.3h 12.1194674 2.2183833 -1.9834217 5.42733996 -1.4539399
Ep.1.3h -4.8586124 -1.8277102 9.9304668 2.85979360 7.5251600
Mi.1.3h 0.7546019 -0.5080832 -4.0712540 9.79564276 3.4010379
Tr.1.3h -4.2764380 3.2457212 -3.8204643 6.50500663 -8.8716891
Ve.1.3h 10.5249420 7.2655681 -8.0334952 10.17322723 -7.9034338
Da.1.24h 3.6227487 -15.1700943 14.0948602 2.11991053 -16.0206293
Do.1.24h -3.8955776 0.8721940 0.1069366 0.87979688 -0.6653389
Ep.1.24h -15.1944163 -5.4511114 1.1154859 -9.41136627 23.6767677
Mi.1.24h 5.5768729 -8.0901901 -14.4258521 1.08203269 0.4732463
Tr.1.24h -14.0433365 12.8503500 1.3246096 -7.36037582 -1.6823870
Ve.1.24h 1.8996129 17.2061442 0.1227738 -0.19838150 5.1133500
Da.2.3h 7.7840095 -2.5899042 10.6826784 -20.12843597 10.6532951
Do.2.3h 11.8210287 2.5225966 -18.8145717 1.62860177 -7.5154817
Ep.2.3h -14.4389361 5.2992468 -7.0756098 -11.08764869 7.4168392
Mi.2.3h -10.1117302 -6.5607411 -16.2860148 2.66620292 3.3823382
Tr.2.3h -16.7066724 7.4068933 -18.7767454 14.52421004 -0.1315609
Ve.2.3h 8.0286445 -4.2886268 -0.7137050 3.46010497 -8.1389640
Da.2.24h 1.3407559 -5.4812241 12.6154400 13.47657609 -18.7024811
Do.2.24h 7.8611065 27.8375739 9.6213440 1.71010265 5.6362646
Ep.2.24h -8.0589300 -2.2373169 -5.2869812 -2.25763608 -1.7795611
Mi.2.24h 2.9568219 -14.4854143 19.2578143 -11.21162731 -1.4458966
Tr.2.24h -4.0622097 0.7946691 17.9094092 -6.43247180 0.1969924
Ve.2.24h 8.4553633 6.7044269 9.3868615 5.24259918 2.5030794
Da.3.3h -0.6830266 13.2848629 -10.4692261 -1.03583144 -14.6117385
Do.3.3h -3.6223897 -2.2900519 21.3462082 -1.63994273 -3.1709029
Ep.3.3h -1.5560913 2.6694252 3.3411144 2.94681209 -10.4011288
Mi.3.3h 5.9478579 4.5660505 -12.8256199 23.16078612 -5.0935903
Tr.3.3h -18.2382331 2.0987618 19.5581968 6.11159267 8.8333237
Ve.3.3h -8.2203828 5.5273378 -0.5966017 9.32008099 -12.2132181
Da.3.24h -10.8979120 -23.3857173 -4.6325926 -12.74951676 -26.8215586
Do.3.24h 43.6917475 -9.7091941 -26.4245899 -11.89990719 7.1290415
Ep.3.24h -18.7516937 -9.8047117 -28.1156169 -19.37301144 22.6076969
Mi.3.24h -2.0903186 -18.8072503 4.4116946 1.65968068 7.6954761
Tr.3.24h 10.4339453 -2.0087182 24.6932886 -2.18777601 13.2801715
Ve.3.24h 2.6154008 -13.0417093 6.3430738 16.09905940 -4.3178936
Da.4.3h 10.8346510 -12.8124771 5.8607780 -12.05943425 -1.1869121
Do.4.3h 16.1735869 -7.4793898 0.2419375 -1.78231583 -5.0658367
Ep.4.3h 10.4726362 -12.8579277 4.5383733 -6.94761871 -5.3891343
Mi.4.3h 3.2489749 -6.9270106 -8.8800128 4.86099499 -7.2777371
Tr.4.3h -3.7737510 -0.9613802 -6.5403034 0.74192997 -7.2453642
Ve.4.3h -12.7295130 -2.6796326 -7.7594678 -3.09483585 -11.7622341
Da.4.24h 4.1376874 -2.2448721 6.7523186 5.91437814 -9.2928104
Do.4.24h 0.2339832 7.7879105 -4.7258108 -3.56357814 7.9579017
Ep.4.24h 12.7289838 4.4021044 6.2848276 16.66496294 11.8269524
Mi.4.24h 13.0939512 2.3016482 -5.9992589 1.13599979 7.1268720
Tr.4.24h -13.3611868 9.9862504 1.7444753 -5.53725890 -0.1092559
Ve.4.24h -4.2480903 14.5879531 1.6170495 -4.66985794 4.2585579
Da.5.3h 17.7773577 3.0432438 6.9431056 -12.15922440 4.6092003
Do.5.3h 10.8254895 7.2367541 14.9738121 5.75154977 7.5064418
Ep.5.3h -9.9473889 14.2814420 0.2223350 -0.25729428 9.3065941
Mi.5.3h 16.5671741 8.3062221 -18.2012795 8.47159867 12.8588819
Tr.5.3h 16.7211620 14.1175713 0.5883314 -8.92854687 -5.7844430
Ve.5.3h 10.7785927 -18.2755603 -0.6090891 -37.93461612 -5.2039673
Da.5.24h -5.4750442 -17.7566305 18.5803770 28.24402256 19.6204939
Do.5.24h 11.4365118 11.3058629 5.3608915 17.84651289 -7.6946288
Ep.5.24h -10.4485267 14.1962938 -9.6939473 1.27212863 -3.5144785
Mi.5.24h -9.2772695 -23.8426849 -13.6435498 16.56015511 2.9649222
Tr.5.24h 5.6199074 4.3103088 -0.4370933 6.50236147 -4.6010850
Ve.5.24h 11.4559407 -4.9388705 -8.9763029 -2.15301960 -19.3310240
Da.6.3h -10.6658555 -15.3911841 6.6630351 -5.28995015 4.7566274
Do.6.3h -7.1756910 -13.4764036 4.0016904 1.64893334 -2.2566700
Ep.6.3h -1.5790667 -17.8289732 5.1274371 6.77841701 5.8568516
Mi.6.3h -11.5710096 -12.9835273 -12.0072117 11.15699525 7.4099385
Tr.6.3h -12.2725008 -3.4039705 -0.1917972 -0.09060376 4.8463611
Ve.6.3h -20.2665865 -3.7476960 -2.7693947 0.62802022 6.4239896
Da.6.24h -29.2465839 11.3905114 4.1650297 -14.06509625 -25.5636320
Do.6.24h -1.4203554 24.5529379 6.2522284 -14.47163304 -2.0460683
Ep.6.24h 1.3084350 29.9928092 9.2943132 -4.23984485 -3.8645452
Mi.6.24h 4.6355872 5.3279950 -0.3992210 -8.90105024 8.5665694
Tr.6.24h 10.6642032 5.4044114 -13.4578146 -0.85834672 11.5117470
Ve.6.24h -17.1298764 10.6928980 -12.0115377 -4.14320397 6.3870530
PC22 PC23 PC24 PC25 PC26
Da.1.3h -4.39802703 2.02779324 -11.02145032 15.04101283 7.8189843
Do.1.3h 0.07898599 -1.90243087 1.81064454 4.87139579 1.4132493
Ep.1.3h 5.30542256 5.39474263 0.63905948 1.50753318 3.4717425
Mi.1.3h 6.53375047 -6.33916135 -4.20838419 -0.88313040 -9.8413336
Tr.1.3h 0.27945551 3.86174379 3.82050943 0.03339219 -2.4026701
Ve.1.3h -1.20645747 -5.93794343 -2.73743354 7.95288822 0.2514667
Da.1.24h 0.83900391 17.79678774 -20.89103272 1.94836353 13.9978169
Do.1.24h 1.49172993 -0.29952413 0.22745511 -0.22880615 0.3935305
Ep.1.24h -27.88216768 14.97248930 4.66643149 -7.90886610 -22.1442482
Mi.1.24h 4.30576592 -6.72213236 10.24120519 -10.54491709 1.4014157
Tr.1.24h 4.87457832 0.04141198 4.90101626 -3.13905442 -1.9950400
Ve.1.24h 2.86326209 -17.31967136 0.96306946 -6.50865898 13.5495580
Da.2.3h 1.28760927 -0.66007958 4.53505732 6.56633201 8.0539142
Do.2.3h -4.22985542 5.53658123 10.29905034 2.93582822 1.5453770
Ep.2.3h 0.43537867 6.39078876 4.76543937 -0.24519816 8.8212251
Mi.2.3h 7.97302120 -4.86835605 6.20535356 -13.17210890 -13.5947852
Tr.2.3h 9.85740839 15.27302760 -11.77053785 5.15221754 10.8331938
Ve.2.3h -2.98481197 -0.69720719 7.16433943 6.34713153 -7.0944845
Da.2.24h 10.03267438 13.51099122 16.13153762 -18.88812242 1.9372223
Do.2.24h -11.90348958 -5.60510221 -8.65496627 4.12357182 -1.0389347
Ep.2.24h 0.64551082 -2.07140535 -0.21100572 2.61596429 1.6985116
Mi.2.24h -9.71762926 -14.61660421 -2.74614617 12.86758693 -11.0997030
Tr.2.24h -7.74094362 -21.40891994 -2.84931941 2.04707105 -7.1956619
Ve.2.24h -5.23358911 -0.97148357 -4.77298973 -16.84636627 1.6989836
Da.3.3h -7.62296332 -7.00956557 5.61931547 -0.64802548 3.2324340
Do.3.3h 3.97457931 -6.85027352 9.14281372 7.29952389 -2.6378460
Ep.3.3h -9.40537104 -0.18037672 5.39076430 -0.76232650 6.5803326
Mi.3.3h -1.61615976 -8.09446487 -2.92365339 -4.18576955 -16.7668027
Tr.3.3h 5.22023849 3.80225292 -0.97304133 -0.91699568 1.5613617
Ve.3.3h -10.09651452 4.17594531 6.83434821 0.27956215 2.8615628
Da.3.24h 16.53519302 -10.90601972 5.26552807 -1.21540186 0.5619051
Do.3.24h 3.49235834 1.77050766 -11.16765807 2.70204173 8.0401424
Ep.3.24h -1.70201253 5.21543368 0.69000591 6.24871734 -5.0443517
Mi.3.24h 10.22636587 9.95100453 -5.40329717 2.62645800 -1.9945017
Tr.3.24h 2.36164055 0.06991058 -13.04542612 -2.33004175 2.1130179
Ve.3.24h -2.51349893 6.03705318 -16.78462546 -8.65473005 4.7385067
Da.4.3h -8.61694934 11.25265622 -5.80951880 -2.15091861 -3.0361380
Do.4.3h -10.16970871 11.75255161 0.40316146 -1.07511145 -0.4022529
Ep.4.3h -9.34488408 11.96478580 -0.28891885 0.10667122 -4.3049260
Mi.4.3h -6.81918140 6.15048943 -2.02529441 -3.86517934 -13.8624550
Tr.4.3h -8.28943965 8.40973443 1.56251643 -0.30098093 -2.4931646
Ve.4.3h -8.57726177 7.28714236 -1.00146590 -0.67409870 -5.8063721
Da.4.24h 16.81695537 -15.21720865 1.67975279 9.46890209 7.4419646
Do.4.24h 3.26853007 -21.83675962 -0.32169789 7.39015071 -0.2225069
Ep.4.24h 5.09665283 -12.61791737 13.05104337 -4.56531783 5.2306212
Mi.4.24h 7.02300443 -3.75459730 7.26445835 -2.68630551 -0.2430419
Tr.4.24h 5.89997666 -1.35164875 -2.81169801 0.89619029 -1.2402686
Ve.4.24h 7.49995392 -2.27421700 -1.61001559 -0.87131141 0.2170568
Da.5.3h 7.41563230 -1.73902412 3.16536624 -10.43402730 -2.2351700
Do.5.3h 12.85868850 7.13924655 7.94589903 -5.80558049 3.4509380
Ep.5.3h 10.44569910 14.15947732 -0.26675843 -4.84081780 10.5547883
Mi.5.3h 15.95183477 -5.07831110 -22.99971324 0.36357103 -15.1408358
Tr.5.3h -3.98760890 11.74702342 20.38872393 35.26871928 -8.5117165
Ve.5.3h 0.53763619 -10.17838881 0.02388113 -23.18054943 14.0849186
Da.5.24h 5.09159600 7.45380722 1.59818041 7.56851309 -9.5453331
Do.5.24h -18.24994050 -0.31526439 7.77693158 6.05539945 12.8643560
Ep.5.24h -34.12032950 -12.51359581 -3.43986753 -1.79124763 7.8267721
Mi.5.24h -10.04517300 8.51733783 3.75284485 -0.84968166 19.4508829
Tr.5.24h 8.30005634 -1.42022737 -14.11055434 -1.12090485 -8.6035751
Ve.5.24h -3.14001128 -0.51054146 -16.86378771 4.85232218 -9.9353983
Da.6.3h 0.71719479 -3.35599425 -1.13142007 1.13930195 -0.7061466
Do.6.3h -3.53972491 -10.45467423 13.43467167 6.93525454 -3.8384970
Ep.6.3h -4.26276620 -10.50181584 9.48657359 -4.78166200 1.8166489
Mi.6.3h -1.87635139 -18.94178523 -10.67258759 -6.08369852 -4.7830205
Tr.6.3h -5.86043696 -4.75126994 6.47760950 1.37709172 3.8218821
Ve.6.3h -2.67702683 -6.98614408 -4.59091683 2.83572321 10.7229813
Da.6.24h 23.87960596 2.93526675 -5.67179941 7.96488040 -12.8298401
Do.6.24h -5.44468481 9.63441367 -2.99436183 -16.80318014 -12.5840341
Ep.6.24h -1.83756877 7.87747936 -5.88231844 -19.93379781 -0.8829740
Mi.6.24h 8.94501867 12.54773700 -3.34936780 15.01422135 -1.6361522
Tr.6.24h 15.45257756 10.70536075 30.68054354 -3.31875325 0.1318148
Ve.6.24h 1.29799276 0.89713225 -12.00207202 11.80813967 21.5031025
PC27 PC28 PC29 PC30 PC31
Da.1.3h -1.09776422 -4.89339545 5.0481269 1.39571680 3.54785921
Do.1.3h 2.20218077 4.21955638 2.9368379 -5.25668706 -0.62167120
Ep.1.3h 3.54141014 1.93546108 0.1299109 0.40888461 2.07679989
Mi.1.3h 8.07048810 -3.71352326 7.2931626 -2.46899447 2.26479185
Tr.1.3h -1.73820978 7.75294051 -3.6318073 0.37340567 3.06910057
Ve.1.3h -1.31871488 7.33738082 4.8109918 -4.72659863 -5.24914120
Da.1.24h 17.24857337 -0.29055049 0.2971112 13.96344306 -5.54435825
Do.1.24h 0.03289363 -0.09440874 0.2490163 0.29323272 0.06461425
Ep.1.24h -7.46798634 3.91811032 5.0702499 -3.43853205 -0.45457226
Mi.1.24h -9.74621336 -1.27680412 -16.9066071 2.97078361 -5.37011490
Tr.1.24h -4.26268770 -8.07438879 -5.6579083 -5.53341204 13.17678549
Ve.1.24h -1.68932381 -9.38973393 -3.1918639 -4.70375615 -7.26128737
Da.2.3h -9.32991346 -18.43452860 6.5759629 5.04457958 -3.56784649
Do.2.3h -1.78407179 0.78832727 -4.5128657 -7.21993367 -2.58107008
Ep.2.3h -1.61691789 -12.21435831 -4.2664509 -1.14323787 -2.59958739
Mi.2.3h 4.48079381 -9.35666210 -0.6115362 4.43356738 1.94822739
Tr.2.3h -5.73869753 13.27816556 1.8122323 3.36007832 -0.23621026
Ve.2.3h 0.57501583 7.84879029 0.4382351 -0.05640628 -9.19275060
Da.2.24h -7.31145289 -6.25022657 23.0354282 -15.02923068 -1.15270871
Do.2.24h 6.59569221 -0.86782410 -11.9545427 11.58384452 -1.68042193
Ep.2.24h -0.53099677 -0.19163602 0.9957238 0.38180113 -0.25820865
Mi.2.24h 5.65151079 16.32845082 12.8210033 -5.38152562 -18.03368044
Tr.2.24h 5.85832405 9.89762113 -10.5847544 19.16158578 12.24583195
Ve.2.24h 11.48714263 3.95641937 -8.5216197 -11.53446139 16.50732281
Da.3.3h -4.60061882 7.71331696 -3.0296241 -8.59384595 8.00882321
Do.3.3h -7.44005520 2.32171675 9.0108773 -2.25476534 8.38865901
Ep.3.3h -7.21009267 9.52423924 -3.9295769 4.15609260 -4.01478956
Mi.3.3h -0.99071113 -9.62580603 11.2837327 8.38374507 7.30516609
Tr.3.3h 5.46209129 -2.50185184 3.5954346 2.29518524 3.44382827
Ve.3.3h -0.81755149 6.48931694 -0.8806659 3.74177009 1.54492764
Da.3.24h 12.26006601 -7.16375964 -9.9992134 17.80369742 -13.00203457
Do.3.24h -3.30997353 6.47710840 -11.1240129 3.70916530 11.86970844
Ep.3.24h -6.76009194 3.95040535 4.8216016 -3.86601053 -2.28134852
Mi.3.24h -3.03881686 -0.88622156 0.5832265 -9.45437991 -10.06190307
Tr.3.24h 7.48288989 -11.87156932 -2.0921405 -7.65388801 12.49376267
Ve.3.24h -2.38840895 -13.57576539 -8.3099425 -16.18289607 -22.63252098
Da.4.3h 0.66523446 -2.96482051 2.6703430 0.58836487 7.92080813
Do.4.3h 4.25190399 1.99415982 -2.0624263 0.72698547 -0.74119066
Ep.4.3h -2.29683789 2.24594710 -0.3110024 2.20258585 3.85022239
Mi.4.3h 8.81009830 -2.10479401 0.6452499 3.66610392 4.12994096
Tr.4.3h 3.91732793 1.53512966 -1.8095712 3.12448290 -1.88389306
Ve.4.3h 1.33328360 4.69796198 -3.2323034 3.62765969 -3.49202184
Da.4.24h 1.48275901 -2.37677213 -1.8221577 -9.60404592 4.89400885
Do.4.24h 0.01136122 4.71358984 -3.3778399 -10.18940776 1.34997295
Ep.4.24h -17.04632123 -1.51916598 2.8594787 -0.46102752 -1.06535586
Mi.4.24h 0.17191730 2.81188523 -1.0219792 6.17531267 -6.19339583
Tr.4.24h 1.74578136 1.10512452 2.6807169 2.92071326 -0.46254610
Ve.4.24h -0.71267447 -3.50720886 7.5430820 1.34910513 -4.89032478
Da.5.3h 6.75794700 19.41089478 -13.5447317 -23.61215202 -2.43148844
Do.5.3h 0.02567908 14.28369133 0.9234762 15.90077421 2.21648598
Ep.5.3h 2.00145657 9.78793721 -9.5886402 0.16109300 -11.97351930
Mi.5.3h 13.01612047 -6.98340282 13.1298226 1.28872368 -10.71628740
Tr.5.3h 1.07938515 -29.54098913 -12.0883246 -1.97623881 -4.34869069
Ve.5.3h -2.59408264 -2.59710818 17.6921870 4.47708315 2.97180908
Da.5.24h -2.15885467 2.48211874 -11.5545910 2.38167947 -0.14967678
Do.5.24h 4.03697708 -2.64266394 16.2078664 -1.02278436 2.50526727
Ep.5.24h 14.80754692 -1.68410069 11.5997405 -0.73268153 -2.97496239
Mi.5.24h 1.88482634 -8.95859006 -8.7242818 -0.76703682 22.13064109
Tr.5.24h -14.71632947 2.79144785 -0.7943623 11.91355837 4.49153251
Ve.5.24h -21.62464165 0.83430846 0.2810043 -9.52598455 2.41771505
Da.6.3h -5.17527762 -1.27294955 -3.1612394 -4.48677782 7.02730106
Do.6.3h -7.63407029 9.62482662 -2.7664994 1.45447132 -4.23376232
Ep.6.3h -2.71590479 1.43082588 -6.7148059 3.34246893 -8.06961074
Mi.6.3h 1.27456965 -11.79436049 2.3711160 1.17822624 6.77194756
Tr.6.3h 1.66065055 -4.18089766 -4.4647313 0.58371938 -2.11605904
Ve.6.3h -0.99420321 -0.30823610 -1.3537212 0.39157818 -8.81015343
Da.6.24h 2.90367896 0.95250183 -1.1521387 -9.67659324 14.86436136
Do.6.24h 14.31324352 -4.28917989 -11.4564857 -9.39428678 -5.54355365
Ep.6.24h -27.00903060 -7.20134504 -1.6255403 17.35991591 -8.13448886
Mi.6.24h -10.73933685 9.01113950 13.5996875 6.42237047 7.78432302
Tr.6.24h 26.15573041 4.10818758 12.1255380 7.39475644 1.99943446
Ve.6.24h 2.35028499 7.04059420 6.6943313 -6.14473257 -1.25477283
PC32 PC33 PC34 PC35 PC36
Da.1.3h 1.15653940 -0.605770922 -3.9045376 -4.5681697 -11.56287224
Do.1.3h 2.38509807 5.963987987 -2.0420572 -2.1462756 -3.26776064
Ep.1.3h -0.48872348 -0.530883885 -3.2072079 -2.0394518 -2.83934711
Mi.1.3h 2.11770368 0.981367190 -6.3293817 1.9032420 1.65143899
Tr.1.3h -8.94684943 -3.783181328 1.1872364 10.9597501 16.47790206
Ve.1.3h -1.44571065 7.670069856 2.6452282 2.1207505 13.08788463
Da.1.24h 16.88693370 -1.620491526 -2.5823809 -4.3456641 2.85046383
Do.1.24h -0.06773709 -0.320116602 -0.1693913 0.4079490 -0.09454115
Ep.1.24h -16.71173132 0.294886865 -1.2868831 -4.4463116 -0.25312319
Mi.1.24h -1.50722936 1.510776567 21.5746358 13.1015498 -7.83830032
Tr.1.24h -1.08911471 -8.712388005 -1.5635019 2.0091855 -6.43044579
Ve.1.24h 8.54207315 -4.031953084 -3.6648697 -10.0679553 -3.86892838
Da.2.3h -10.54446133 -10.431555960 6.1402623 5.2194084 22.01237277
Do.2.3h -0.14360646 2.732232896 -2.4148922 -3.4988834 -4.44546789
Ep.2.3h 7.62194844 -4.672915703 6.7145107 3.3544916 3.30012878
Mi.2.3h 1.19373012 -8.659482652 -4.7669671 0.7005959 -0.43232429
Tr.2.3h -9.13430116 5.252240615 -6.3719807 -7.0646193 -22.30997791
Ve.2.3h -2.92908212 -13.207819750 -6.1828569 -1.1775760 -1.86363720
Da.2.24h 16.50171440 -0.011735367 12.5544740 5.0494127 -5.04363424
Do.2.24h -15.68224579 -0.706440256 -4.0446927 -3.9857337 0.86593388
Ep.2.24h 2.11502401 -0.385665384 0.4205650 0.6821088 -0.14485042
Mi.2.24h 11.96292855 1.105727782 -13.2080565 1.3755734 9.48594829
Tr.2.24h 13.99329612 -1.007623132 9.6197957 13.3934218 -15.08906696
Ve.2.24h -6.01222037 22.758205178 1.8988451 -11.8456111 17.18050857
Da.3.3h 5.83928816 10.887597071 -2.9805480 -5.0851882 9.30979183
Do.3.3h 7.14984521 11.723669485 4.0269659 -3.0854147 -4.78990100
Ep.3.3h 1.29914170 -2.135706564 3.7820476 -5.7724119 -4.35894413
Mi.3.3h -2.85599573 -8.564450492 -0.8454966 -11.9846461 -2.20983477
Tr.3.3h 1.42289426 0.003196677 2.3782963 8.6308873 0.31845545
Ve.3.3h -2.41279066 -12.262817031 2.0098731 10.1315374 6.41453869
Da.3.24h -22.41105479 17.606733775 5.3229485 -9.0760086 -1.74368109
Do.3.24h 10.03016596 -16.711843518 -6.1315426 3.2098571 2.71567602
Ep.3.24h 17.59038103 13.324634980 1.0449597 -1.1270530 0.16305936
Mi.3.24h -6.96315784 -2.741042918 -6.2928364 -2.5053318 5.74017769
Tr.3.24h -6.92971945 5.678961717 3.7977060 9.5419171 -10.86830098
Ve.3.24h -8.88561618 -3.820961668 -4.4197007 5.9326115 -4.73200041
Da.4.3h -0.91108174 4.684645937 1.0249345 4.4831605 -2.53434648
Do.4.3h 0.42556479 2.480025439 2.1490234 1.0244768 -1.98379587
Ep.4.3h -2.88476143 2.404211888 1.3783223 -0.5518974 -2.33068824
Mi.4.3h 2.51442579 1.236660980 0.9344290 5.1525626 0.44970795
Tr.4.3h 0.47479454 -2.500687987 1.5455543 4.7008654 1.50074397
Ve.4.3h 0.19021161 -2.466292069 0.9662768 7.5465640 5.71097340
Da.4.24h 0.50611116 -2.512426826 -0.9514945 4.5879762 1.31103914
Do.4.24h 0.08131720 -0.570479836 1.9218210 6.3571630 2.97236854
Ep.4.24h -6.14693623 0.875473259 -2.4424746 -2.0888313 0.68618225
Mi.4.24h -1.98016121 3.347395839 4.9640392 -5.5637209 -3.10680116
Tr.4.24h 1.80715448 -3.354732869 -4.8020185 -7.8776877 -1.70786429
Ve.4.24h 2.18505742 -4.968817875 -9.8733292 -20.2618654 -1.45805470
Da.5.3h -8.47553454 -3.666527418 -11.7561480 7.2526509 -9.40945226
Do.5.3h 0.74136114 3.912903213 4.9941570 -6.5884251 15.09415901
Ep.5.3h 3.56183981 -2.814604682 4.8166228 4.8957308 -0.68962219
Mi.5.3h 1.17624133 4.179068011 6.7342787 8.3463878 -2.17025715
Tr.5.3h 6.07220365 10.371363182 -3.7306696 -1.6492906 -2.85374184
Ve.5.3h -6.50486341 -3.680534919 -3.8378422 -4.9324672 -3.13406491
Da.5.24h 5.01398232 1.597069529 3.1689055 -2.0699829 2.95250495
Do.5.24h -11.54814750 -10.540731191 5.8638709 1.0440595 -4.30117645
Ep.5.24h -1.57747573 2.695063273 -0.7812711 8.6370564 -7.20610040
Mi.5.24h 4.26437924 -0.483170503 -15.6969484 -6.8011132 4.52058758
Tr.5.24h 4.41083904 -8.074353677 0.5352457 -5.6913496 7.24041200
Ve.5.24h 0.75668603 9.238330558 10.1456109 -1.3948738 0.25209530
Da.6.3h -4.47496275 1.749901468 0.1181261 -1.6184280 -2.80216945
Do.6.3h 1.08719261 -4.386537582 -4.0502151 -11.4471130 -8.43272257
Ep.6.3h 5.09122223 -0.292288409 2.0924899 -5.3627721 -4.51750285
Mi.6.3h 1.13834773 4.219514336 0.1617657 0.4843595 4.17903955
Tr.6.3h 3.02689479 -7.287910613 0.2790905 2.6489380 4.47143059
Ve.6.3h 0.92252746 -5.294294462 -2.3231854 5.7090897 9.24720518
Da.6.24h -5.80722554 -8.903208642 -10.1161641 6.1233069 2.27932889
Do.6.24h 12.29637258 -11.705267659 17.9308690 -21.9314056 1.36549514
Ep.6.24h 6.69222627 17.548662146 -23.8473930 15.9884670 -0.72121230
Mi.6.24h -13.03781411 -6.272136710 14.0508708 -2.1340433 -5.08919249
Tr.6.24h -1.34271671 6.752682719 -9.7946980 9.9467134 -1.51885566
Ve.6.24h -2.39263037 9.912589257 15.5189789 -0.8662053 4.34700714
PC37 PC38 PC39 PC40 PC41
Da.1.3h 9.35689299 8.834886019 5.4093132 10.36226496 11.3165863
Do.1.3h -1.47409360 0.004914499 -4.8329609 3.66886270 -0.4955024
Ep.1.3h -1.00268065 4.272686868 -6.4101712 3.94506040 4.5512967
Mi.1.3h 4.65258830 2.041088878 -8.4119881 8.96117821 -0.2900003
Tr.1.3h -1.36002524 -2.672678634 4.1718260 -10.86967400 -6.9616343
Ve.1.3h 2.48279001 -1.613834831 -1.9719862 -5.34510986 -10.5372948
Da.1.24h -1.99124930 6.534610772 7.7294079 -0.32737684 -8.7587636
Do.1.24h 0.12782153 0.271109554 0.6988516 0.25466135 -0.3433938
Ep.1.24h 2.61067223 -10.154984433 -15.4951263 -2.62087366 8.9466165
Mi.1.24h -4.57187147 2.855708020 -2.0958369 16.21282780 -5.1425596
Tr.1.24h -7.66740877 -2.583539237 11.4176940 -12.89836406 9.2806899
Ve.1.24h -0.18534853 -4.138318421 8.9788206 -6.69178347 2.9779451
Da.2.3h 4.14452011 0.998223200 -4.2822109 -8.47395430 -23.0435445
Do.2.3h -2.07093061 0.473248750 7.2447154 4.18371212 12.6572606
Ep.2.3h -4.24321797 1.553792530 1.2544396 2.74937087 16.8916322
Mi.2.3h 3.90238895 -0.414790098 3.5346640 2.84973393 2.5521498
Tr.2.3h 2.95767113 7.573931332 -7.6410451 -10.19781704 -10.6495228
Ve.2.3h 10.65960840 -4.389421482 9.9203739 9.31860124 3.1239872
Da.2.24h 10.57270819 2.177897825 -12.8117745 -3.53003634 0.9067661
Do.2.24h -4.74255812 0.078932206 4.1201956 1.39332029 -0.1845542
Ep.2.24h -0.64773278 -0.168983119 -0.5354191 0.41618668 0.8329378
Mi.2.24h -4.62854419 -6.300923279 -0.1453286 -6.22837353 12.0174996
Tr.2.24h -0.54659468 -11.960721564 -0.7756947 0.77573139 -8.4555074
Ve.2.24h -10.87616812 12.926862622 -2.1317022 8.15429497 -2.4823085
Da.3.3h -3.71320255 1.851176907 -3.0001943 -1.38831775 3.1466018
Do.3.3h -6.45696502 -6.101563141 -3.3380677 -2.26662325 -4.6465463
Ep.3.3h -0.47439160 -0.722890206 -2.4428172 -4.55631313 -4.4903197
Mi.3.3h 4.28445711 -5.038130137 3.9502465 3.90212776 -1.3931475
Tr.3.3h 5.68984849 3.931671310 -2.6126839 -2.65905311 -0.2272599
Ve.3.3h 3.07676505 8.072615567 2.2753834 -3.04309501 3.2273309
Da.3.24h 9.65917695 -1.160944664 0.3452857 -9.27197311 10.2983344
Do.3.24h -2.70954489 -4.605942117 -19.9450878 -3.35565752 6.2350198
Ep.3.24h -3.07769056 5.827426293 22.9345089 9.94315084 -15.1587373
Mi.3.24h -4.36972772 5.640741850 5.0058831 4.38052656 1.1372253
Tr.3.24h 3.82763498 1.851058969 3.4810351 -2.74091879 3.7305244
Ve.3.24h -10.80983517 -9.096907078 -4.5398079 9.18425034 -6.1880845
Da.4.3h -0.16589991 -0.958645071 4.3724964 -0.27752257 1.4351718
Do.4.3h -1.41672892 -1.253991153 2.7875487 0.82344126 3.9076438
Ep.4.3h -3.12945256 -4.432147856 2.7904038 -1.03651842 -0.2985753
Mi.4.3h -0.18046622 -4.034265928 3.7919413 2.39134466 -0.2941147
Tr.4.3h 1.85299958 0.345791637 0.2594439 -0.52852030 -0.4507932
Ve.4.3h 0.09372455 0.792008057 0.1327431 -2.15648342 -3.2820986
Da.4.24h 0.07675249 3.244163950 1.8617619 -6.73149897 6.4807152
Do.4.24h -0.09461763 7.254653646 -6.8867963 -4.86856713 3.7193081
Ep.4.24h 3.46118937 -5.724460188 12.9967883 -0.98529217 -0.9031008
Mi.4.24h 0.10082160 4.434047003 -9.2985097 7.50753981 -5.5755816
Tr.4.24h -2.43656807 -0.699758062 -4.2708427 -1.25418537 -2.2491662
Ve.4.24h -2.01397428 0.351891978 -8.3152024 2.85887135 -4.8648154
Da.5.3h 23.04635420 1.996730819 8.6810990 0.06025175 -11.8890442
Do.5.3h 2.40801120 -6.513840429 2.5559327 12.51451085 6.4008009
Ep.5.3h -20.94779268 -0.916255883 -6.6560360 -3.67230856 8.6554135
Mi.5.3h -9.12276415 -8.746029054 2.6773823 -13.88183784 -2.4556632
Tr.5.3h 3.73751472 0.620610987 -9.6867286 3.87665338 -4.9491400
Ve.5.3h -5.69518891 -1.704869073 -0.6277411 4.89064733 -1.3477445
Da.5.24h 3.08353179 -0.126461187 0.2641340 -2.84881857 2.3200891
Do.5.24h -17.26516675 -5.492465730 12.4385137 9.13014837 -1.1193160
Ep.5.24h 6.33658705 15.834068694 -10.3579282 1.24935224 -3.2977701
Mi.5.24h 5.83682119 -14.100643224 1.9306448 -10.14528099 -5.3301551
Tr.5.24h 11.65914547 12.222864168 -4.3190663 7.74113428 4.3573924
Ve.5.24h -1.45180536 5.268026713 7.1413572 -8.72152558 7.6233834
Da.6.3h -6.92102508 2.634906402 -4.0223710 -7.47210195 -1.3507875
Do.6.3h -12.60766048 -0.541683019 -2.1759367 -5.88604377 -9.0881895
Ep.6.3h -2.77201829 1.196748221 -5.7508906 2.59529318 -3.3914833
Mi.6.3h -1.41392685 3.709066350 -0.8113563 1.91284926 2.8187554
Tr.6.3h 4.16587038 8.493360063 2.1589725 1.12354434 4.5214422
Ve.6.3h 6.40409394 10.557367230 1.2225490 2.44452200 5.2349359
Da.6.24h -9.80007150 -8.059412420 -4.5573493 19.37152338 -6.5000190
Do.6.24h 7.23186535 -2.156819817 4.6113361 -10.15022861 -4.2792283
Ep.6.24h 3.24960524 -4.030090123 2.0674056 -2.15193051 1.5793887
Mi.6.24h -0.48795566 12.474072529 4.9412406 -4.94943133 1.9306916
Tr.6.24h -3.40721642 2.805786416 2.2715344 -5.96924077 2.6454272
Ve.6.24h 18.19964873 -31.392338179 -3.2712149 9.00516173 4.9045042
PC42 PC43 PC44 PC45 PC46
Da.1.3h -9.1554446 -6.90957254 -4.37074125 -7.57479204 -0.8858400
Do.1.3h -3.2775216 6.09267000 -1.05685669 -0.66231130 1.2472975
Ep.1.3h 4.0781983 2.22483363 -4.75590576 -0.04732287 0.4443261
Mi.1.3h 10.9200559 -0.40498807 -13.40214339 -3.78413084 1.8343517
Tr.1.3h 8.5139836 1.10153638 10.69281791 11.19368198 -9.5554479
Ve.1.3h -2.9655813 18.21445186 10.20690938 -4.95351959 4.9867110
Da.1.24h 7.9961011 1.49232297 -2.05728559 2.58385632 -2.5516231
Do.1.24h 0.4531914 -0.09693303 0.31429170 0.08709914 -0.1589123
Ep.1.24h -4.3528389 3.07557020 2.97044665 -6.13744745 5.8616100
Mi.1.24h -5.0460326 -14.59137533 1.28532078 -2.06383968 -0.8745167
Tr.1.24h 2.4391207 -7.80516912 -7.51493027 8.53929571 -9.2707129
Ve.1.24h -10.9016528 -3.08258503 5.53618336 0.64815768 11.1679756
Da.2.3h -5.0640189 -5.84983050 -4.85957834 -4.48173340 -1.8452641
Do.2.3h -4.3103973 7.60732675 6.25739602 -2.94602528 -5.6147788
Ep.2.3h 8.9002543 18.34900841 5.18558330 -1.14054556 8.9476200
Mi.2.3h 15.0516850 -3.70753675 -4.13685518 7.79476845 -5.6186896
Tr.2.3h 3.9305243 -17.24812346 6.80249073 2.37570442 9.3122082
Ve.2.3h -16.0283318 -1.54191378 -8.28731513 -6.58378843 -9.1865492
Da.2.24h -4.9789370 2.47318281 1.26365722 0.32315368 -1.6670736
Do.2.24h 3.1041008 -1.39236848 -1.60994226 -1.40977280 0.3414549
Ep.2.24h -0.7538607 0.48687510 0.45036296 0.26999126 -0.5273448
Mi.2.24h 1.8269984 -12.86238244 6.94654478 13.32170415 5.3436988
Tr.2.24h 0.9893457 15.24420761 -2.58389248 -5.44281146 7.1245765
Ve.2.24h -6.6516156 -2.58274360 -8.74150272 -1.44292347 -6.0787085
Da.3.3h 2.6042320 -1.34099902 7.60936078 0.49631494 9.2260607
Do.3.3h 7.2152925 -3.44716888 -10.29064805 -4.38793768 -1.4029565
Ep.3.3h -4.1514419 -1.16539494 9.83323566 -1.66740134 -4.0271012
Mi.3.3h -4.2701372 4.72205469 -0.66900556 9.32674978 -12.9798983
Tr.3.3h 1.5151579 -4.22235435 -0.74889497 -2.98494655 6.2390659
Ve.3.3h -4.9028922 -6.70887353 -12.90977666 -8.11640190 9.9084964
Da.3.24h -1.9202173 4.33457997 -1.60078313 -0.97378700 2.7970260
Do.3.24h 4.2124359 -4.69619038 -3.93994990 0.72155915 1.7352320
Ep.3.24h -4.2610069 2.02537099 0.79643518 4.89229809 -2.3254728
Mi.3.24h 15.7137347 3.33818480 2.99598586 -19.96548583 -8.7766241
Tr.3.24h -2.7994198 2.06431494 21.50598629 0.22522941 -10.4844970
Ve.3.24h -3.7449347 5.91325631 -7.99001215 19.53654811 6.9764901
Da.4.3h -4.2462921 -9.79286149 3.77579833 4.00273604 4.3600715
Do.4.3h -3.9263434 2.23261258 3.21375123 -0.66742877 -0.2184907
Ep.4.3h -1.1373528 -3.52805825 2.91887221 1.04819712 -4.3430322
Mi.4.3h 3.8832531 -1.12577362 -1.61058071 1.60784204 0.5423792
Tr.4.3h -0.6106947 1.96559100 -0.25149449 -2.30451189 1.6093436
Ve.4.3h 2.7813818 -0.67879873 0.28609116 -2.15680597 -1.5158535
Da.4.24h -0.9575749 2.45277277 -3.59291104 2.09744955 -7.4959347
Do.4.24h -2.8202530 1.88841787 -2.55465933 1.16779467 -9.8964778
Ep.4.24h 4.0708501 -8.13710405 4.15051086 2.98729725 8.5442000
Mi.4.24h 3.5477761 1.20403708 -1.42163689 -1.68251916 3.6177865
Tr.4.24h 2.7882893 2.26482250 -0.82917406 -0.56822694 -1.1709578
Ve.4.24h -1.7963605 9.77585212 -4.00480103 -4.01173133 0.7428602
Da.5.3h 9.4544769 7.83739126 -3.79341043 1.50246998 5.6581718
Do.5.3h -6.1020933 -5.38826929 -4.08981350 14.62563504 5.2688672
Ep.5.3h -3.4725081 2.76488842 -2.02571252 0.40679517 -10.6603078
Mi.5.3h -14.4563619 -3.25883723 0.63252211 -11.62407584 1.2267330
Tr.5.3h 5.7643949 -4.24766630 2.59685633 7.29677859 1.4703296
Ve.5.3h 1.2132177 0.87991500 2.86557620 0.07392653 -0.3750206
Da.5.24h -3.2945477 0.84321347 -0.73989097 -0.89078008 0.6107259
Do.5.24h 15.7804143 -0.61239800 4.40096417 -9.92650515 6.7671232
Ep.5.24h -3.3268382 -0.94751354 -2.79846392 10.18690418 -10.6301772
Mi.5.24h -11.7760796 6.74804955 -2.72338092 -2.67724596 2.4206955
Tr.5.24h 3.8289992 -1.59228821 21.32568697 -2.80895935 -6.1793134
Ve.5.24h 4.5631799 -1.29423451 -15.07776641 -7.92906088 6.8663150
Da.6.3h 2.6474263 -2.56980437 -0.02738687 1.78196971 -1.1806976
Do.6.3h 0.5341252 -1.10277038 -3.60780226 -4.16966455 -13.8603869
Ep.6.3h 0.1676379 4.08853599 7.76384446 1.74512497 -1.9334152
Mi.6.3h 9.1253309 -2.28018541 3.04342212 4.35957654 13.0002885
Tr.6.3h -3.4046637 0.21316172 -2.24882049 -3.25753594 3.2318442
Ve.6.3h -6.4996519 -2.79170791 1.23079419 -3.56015406 3.2706024
Da.6.24h -13.5520187 -2.57259331 9.07485701 -2.17472161 7.8768843
Do.6.24h 3.5270152 -6.54991496 0.69316687 -2.05498928 3.2871844
Ep.6.24h 1.5803757 4.20490153 -5.62316721 -3.44560138 -6.5824937
Mi.6.24h -3.7043789 18.70044991 -8.01108834 20.09627560 5.8996271
Tr.6.24h -0.1670267 -3.22192121 1.88660489 -4.33726945 2.5532761
Ve.6.24h 10.0647664 -5.47515625 -3.95434681 -0.30817322 -12.4449401
PC47 PC48 PC49 PC50 PC51
Da.1.3h -5.172022530 -0.60473939 -2.94374348 13.81421197 2.506399747
Do.1.3h 2.169719350 0.76682192 -2.57940533 -1.93797470 -0.705628224
Ep.1.3h 1.853742491 1.02943495 -0.37586224 -1.40799813 3.548980052
Mi.1.3h 3.031689488 1.85224961 -5.42928800 -9.93105112 6.678880221
Tr.1.3h 5.968972703 -4.34527546 8.38485386 20.75754535 19.587200758
Ve.1.3h -11.860572335 2.79845832 -4.11242461 -10.50902160 -14.631736418
Da.1.24h 0.150720537 1.25964612 0.91036824 -3.28074152 0.729391490
Do.1.24h 0.184474572 -0.20698695 -0.01322022 0.24007828 0.391369380
Ep.1.24h -0.151598823 -0.57399117 -0.33465088 2.38316752 -0.934374300
Mi.1.24h -0.850128964 10.05067399 0.97229885 5.57852326 -1.869589802
Tr.1.24h -2.779192487 -4.17398215 -4.14258999 -7.65884550 -13.255571046
Ve.1.24h 6.855614621 -6.96231680 9.34709189 -6.26936734 -2.847165992
Da.2.3h -7.042592538 2.39506362 -5.62646255 -4.21444506 -2.357770968
Do.2.3h -0.276835393 -7.38119663 -11.33966633 -6.66860415 4.183387241
Ep.2.3h 9.660655184 4.12132767 21.37555126 5.87846886 -7.098920783
Mi.2.3h 0.708291025 1.55294501 -7.59075862 -9.57620594 14.122667891
Tr.2.3h -5.745109519 -0.68825354 4.32887477 4.69122504 -5.171012751
Ve.2.3h 1.272772944 2.35801738 -5.56460653 5.16677087 1.073700620
Da.2.24h -2.624614876 -3.12952421 -0.18656073 2.77749539 -0.476529882
Do.2.24h 1.167087877 0.38731084 0.87355206 -1.56952317 0.230551719
Ep.2.24h 0.175650668 0.68202618 -0.15217005 -0.01659473 0.007705817
Mi.2.24h -0.309459061 12.13814790 1.66420097 -1.82615835 -2.135529490
Tr.2.24h -8.741642947 -14.03056173 -2.60263874 5.77143634 1.057056607
Ve.2.24h 10.526588990 2.05629697 7.72943120 -0.23149294 -2.759734450
Da.3.3h -5.044097080 -9.82259268 -17.75030779 11.93358996 8.094936054
Do.3.3h 14.839956164 0.86062919 -3.17926149 3.93149584 -4.547900069
Ep.3.3h 2.653142681 8.31547727 8.13371454 -15.09764085 8.271325037
Mi.3.3h -12.140190860 8.06746770 15.23052269 8.42243968 -11.329683937
Tr.3.3h 5.408224787 7.35867858 0.54367171 2.50118957 1.515300064
Ve.3.3h 6.010159648 -3.36174181 1.43123063 -12.24275411 -0.711254365
Da.3.24h 2.505518308 2.44786843 -3.99159864 0.63940705 -1.376188474
Do.3.24h 0.453921230 -0.03026986 4.48795369 -0.18244311 0.106885568
Ep.3.24h 0.714275899 3.60752991 -2.56144828 -0.32377570 0.212403681
Mi.3.24h -9.717444820 -23.90330394 8.14311564 -1.42153281 -3.775518652
Tr.3.24h -10.307977918 10.22718173 -2.36212286 -6.61998002 9.424937081
Ve.3.24h 3.788511574 -5.58662993 -8.09564334 6.56551741 -3.784567857
Da.4.3h 2.294216817 -7.75491645 0.75343478 1.17246077 -3.959045716
Do.4.3h 2.158232329 0.24123546 -0.36245116 -3.10220503 -0.101621526
Ep.4.3h 0.135010131 -2.73507054 1.12112504 -3.97714411 -0.999878335
Mi.4.3h 0.993154182 -0.10729010 -2.43219046 -3.53853159 -1.933127057
Tr.4.3h 1.009987383 2.12935999 1.02816204 0.05475217 -1.236181936
Ve.4.3h -0.394388574 1.78321472 1.55337470 3.26286558 -7.986782520
Da.4.24h -0.189927404 -2.26430132 0.34139899 5.36544919 -2.859161308
Do.4.24h -1.527630019 5.91366178 -2.48203289 4.57825520 -4.687323945
Ep.4.24h 0.363231667 -11.07179627 1.06346649 -7.84139936 7.111948383
Mi.4.24h 1.184948305 2.77598580 -0.60760541 1.07756883 1.215325383
Tr.4.24h -0.487428960 3.30579438 -2.90969012 -1.85471965 0.765689600
Ve.4.24h -6.085435322 6.07521758 -0.42795325 5.73757970 12.875582121
Da.5.3h 3.339020909 6.73536778 4.31864588 1.59171836 -5.698615870
Do.5.3h -14.080174070 -9.04876013 6.40128997 0.94020137 -2.307248506
Ep.5.3h -11.863273085 5.83706530 -11.16543491 -4.28452923 -0.252825448
Mi.5.3h 15.242903825 -6.86698412 2.58488398 3.18867674 6.060993212
Tr.5.3h 0.006810163 -2.99481091 3.52384038 0.46808773 0.014922562
Ve.5.3h 0.018830858 -2.54481823 0.40029460 2.61082877 -0.727152243
Da.5.24h -0.740742610 -0.33990203 0.11662043 -0.79357988 -0.360112407
Do.5.24h 2.619404208 13.25225838 -6.26495105 6.01127490 -1.620810348
Ep.5.24h -1.804179978 -14.93067993 6.63094242 -6.37270882 2.004541357
Mi.5.24h 3.238265613 6.37610561 -4.58046795 1.97777240 2.301513711
Tr.5.24h 19.126108624 -1.68533537 -12.59651353 -0.32580659 -11.745355964
Ve.5.24h -14.272725872 8.31618626 11.22117547 -2.82614492 12.272788971
Da.6.3h -0.093280700 -1.23917207 -2.08601644 0.24126201 -3.549320786
Do.6.3h 5.393962971 -4.11584250 3.53685707 3.53918508 -5.548804187
Ep.6.3h 3.314144867 0.96750849 7.79217235 -9.48119589 10.358691334
Mi.6.3h -9.782657395 2.16403638 -5.83792058 -0.67179046 -8.442043283
Tr.6.3h 0.898794228 1.09546260 0.58180848 1.00377585 1.754195790
Ve.6.3h -4.156951091 -0.02121258 -1.39459706 8.92465388 4.341547570
Da.6.24h -0.837665309 -1.22003281 7.70840074 -7.98195701 3.917515081
Do.6.24h -2.921136078 -1.01972804 -6.32154806 5.30040855 -0.331286999
Ep.6.24h 1.960618587 4.97650359 -0.64049581 1.77562561 -1.619900949
Mi.6.24h 9.430143055 -1.70574416 -5.77605195 -4.32525463 3.805220514
Tr.6.24h -4.943643854 1.58195311 1.36727961 3.23916384 -3.888822374
Ve.6.24h 4.117241009 -1.39240673 1.21874588 -4.75101087 -0.919455449
PC52 PC53 PC54 PC55 PC56
Da.1.3h 3.38056648 8.65806462 4.07981438 4.66866733 -0.31010508
Do.1.3h 0.46270631 -9.05754722 -3.12091660 -2.33636033 2.18280342
Ep.1.3h -0.20328085 -3.06711932 -1.78383465 -1.37492927 4.67632346
Mi.1.3h -4.39258676 -2.31520786 -3.96871415 1.47782010 -18.52139255
Tr.1.3h 1.21405784 2.34564489 -1.78977954 -11.81892006 -2.94703468
Ve.1.3h 5.88659616 4.08144137 2.31166175 10.65872922 13.01430330
Da.1.24h 3.15857610 -0.94977990 0.10987477 1.03449588 1.24249262
Do.1.24h 0.24853655 0.19863513 -0.34587884 0.23386268 -0.20760213
Ep.1.24h -3.38110986 -0.35745802 1.32592334 -1.43563389 -0.66768885
Mi.1.24h 5.20308587 2.14194147 -3.75298603 2.27799643 1.05151729
Tr.1.24h 0.33941346 8.67566702 -12.54026117 3.44950939 9.84187544
Ve.1.24h -10.30465539 -11.64911505 17.71792454 -5.55043280 -10.28337375
Da.2.3h -0.41406439 -3.14694055 -3.41268494 -3.57205304 -7.65850535
Do.2.3h 2.58922131 3.75983985 -8.04714592 -14.33290502 -2.76206747
Ep.2.3h 5.42003655 3.33143892 -7.48307747 9.10219195 -4.15491515
Mi.2.3h -5.88367702 -2.50006972 15.15765467 13.04287159 11.47138184
Tr.2.3h -5.00761951 -2.98964635 -3.12464564 -1.32500969 -2.90334474
Ve.2.3h 0.62646585 3.05927325 4.10936241 0.06012049 4.52419710
Da.2.24h -2.56239860 1.67708629 1.36859415 0.98807346 -0.62322260
Do.2.24h 1.75559334 -0.29543228 -0.64538176 -0.28529619 0.90998464
Ep.2.24h -0.47765207 0.07937060 -0.05877421 -0.01407693 -0.99674902
Mi.2.24h 3.81760723 -2.43949863 -4.25345928 -0.68728341 -0.73218907
Tr.2.24h -1.50443961 -1.02357577 2.32563674 -3.87425806 0.63720684
Ve.2.24h 1.34660124 1.66326990 5.06381325 1.32687686 2.43689733
Da.3.3h -1.83641807 -8.06026860 -3.46668278 13.76116998 -0.95192522
Do.3.3h 11.58103822 6.39427316 9.05572937 -10.76064646 -1.40645476
Ep.3.3h -10.33805875 27.33141419 6.96641413 -2.61910322 1.74095324
Mi.3.3h 6.91492253 -13.10634686 2.48967504 -5.40164784 0.89932384
Tr.3.3h 2.05600405 -3.71662485 2.99625549 3.10387794 9.47923161
Ve.3.3h -2.95029458 -9.44243210 -15.30734455 -5.69412398 0.38446075
Da.3.24h 1.83567365 -2.01894837 -0.07969722 -0.02415328 -1.53596472
Do.3.24h 5.05939570 3.01685605 2.48477809 2.34239880 1.79993972
Ep.3.24h -3.15312422 -2.30698687 -5.27539244 -2.34297012 -0.50281557
Mi.3.24h -6.10381924 0.95323616 5.47063680 -3.57742729 2.17636897
Tr.3.24h -0.63265375 -3.64271738 -6.38725389 8.96927498 -11.13198554
Ve.3.24h -1.96414713 5.06963289 -0.40565048 2.64103578 -0.20471367
Da.4.3h -3.86281121 -8.23010221 3.73346003 -5.13240602 12.72583480
Do.4.3h -1.06516684 -2.75175653 -1.02223472 -1.28121088 -7.75013182
Ep.4.3h 1.06920185 -0.26809144 0.74122112 -1.19298133 1.18454321
Mi.4.3h -1.70179792 5.33188896 -0.59347928 0.30530327 -9.74336097
Tr.4.3h -0.05145878 -2.09290805 2.69382781 2.62504707 -3.59379747
Ve.4.3h 1.80279405 0.15965686 9.39163769 7.47019714 -5.40430283
Da.4.24h -7.71783550 -0.96015715 -8.79097575 -4.39379668 1.24758714
Do.4.24h -18.96641601 0.23289551 8.38402943 -1.89590941 0.10737634
Ep.4.24h 24.25769142 2.10144984 3.29930338 6.28361003 -2.41286470
Mi.4.24h -1.31711614 -2.70141643 -4.56396775 -0.35676443 3.23852522
Tr.4.24h 1.54012775 4.37931617 -2.16723171 1.97203161 0.98229585
Ve.4.24h 5.33978439 5.75757303 -11.74408547 -4.87036137 6.12148314
Da.5.3h 2.67834965 0.57010670 -1.16626324 -2.59580350 -0.08776388
Do.5.3h -14.45654698 6.42642078 -6.31942924 6.39157480 -2.21171977
Ep.5.3h 12.28693470 -9.45671172 11.30746080 -9.38651893 -4.98931827
Mi.5.3h -1.62391929 5.27469354 -6.57261671 5.85396766 5.52969398
Tr.5.3h -2.97083531 0.16422930 3.69798036 -0.90148423 2.97420825
Ve.5.3h -0.08166062 -0.39572012 -1.50778169 -0.79678332 -0.56067729
Da.5.24h 2.02223109 0.75287218 -2.24012096 -0.41509453 -2.15590691
Do.5.24h -10.64032422 -2.28552674 1.17167566 0.87081831 4.02204939
Ep.5.24h 10.12095731 2.55620381 -1.25033904 1.01763327 -0.20792325
Mi.5.24h -0.39107302 0.39231440 1.43536200 1.04286826 -0.97834504
Tr.5.24h 2.32207918 -2.48151291 -0.64256408 -2.95781076 -1.22626331
Ve.5.24h 1.71858553 -3.70203956 3.21379711 0.32480883 -0.77251115
Da.6.3h 1.76148045 -3.49769848 -1.80267779 1.92366416 11.19134280
Do.6.3h -1.69008993 -0.85155254 -4.57889759 19.25978000 -15.11594025
Ep.6.3h -6.03074418 -12.04776354 -6.56653948 -5.70183709 12.62522366
Mi.6.3h -1.06120915 15.18082937 -0.52510065 -16.74373899 -5.61363292
Tr.6.3h 2.69934491 -1.55834561 -3.78649142 0.70262531 0.46628149
Ve.6.3h 2.63194924 4.05293511 8.76571245 2.62185678 3.98324677
Da.6.24h 3.97147776 -1.00462215 2.57623755 -0.47793186 -1.56718295
Do.6.24h 0.94462712 1.37363987 -1.32778239 -1.30218074 -0.80573147
Ep.6.24h -6.11128123 -0.72438489 -1.91770579 -0.12904391 0.88758995
Mi.6.24h -1.94439633 -0.06769035 8.14270220 1.72226465 -2.89148670
Tr.6.24h 2.71527850 3.53632190 4.38829954 -1.73703677 -0.64477953
Ve.6.24h 0.01568910 -3.51671695 -1.64060974 -0.23109839 1.47914701
PC57 PC58 PC59 PC60 PC61
Da.1.3h -7.02418247 -11.53195584 -15.59319390 8.305523921 3.21996838
Do.1.3h -7.76417079 -3.71532476 12.50019697 -6.143322564 -4.81000290
Ep.1.3h 0.60182388 -2.16533200 2.97420546 -8.262611317 -5.94365155
Mi.1.3h 12.75065026 11.54751625 12.57756076 4.042696829 2.28772663
Tr.1.3h -2.92898985 2.29547850 -5.89469703 0.078521436 -3.01993858
Ve.1.3h -3.84570232 6.57742889 -8.06750139 2.861701886 7.91108132
Da.1.24h 0.52536468 -0.31626840 0.95027820 1.354737995 -6.73845463
Do.1.24h 0.07997864 -0.49059150 -0.16990285 -0.411935533 0.16693171
Ep.1.24h -0.21042401 -1.90323258 -1.62557787 -3.652196165 5.19189515
Mi.1.24h -1.36151857 6.86297578 2.40137075 3.588522831 4.24098978
Tr.1.24h 10.32643747 -9.66250414 5.04726918 3.442364409 -2.11512462
Ve.1.24h -0.04581178 0.82629773 -6.01297450 -6.197330202 1.15434622
Da.2.3h 2.43637272 -6.96409570 0.31913018 -1.377415889 0.50009070
Do.2.3h -11.69427386 -9.89868931 9.18599904 -2.486874797 -4.98350121
Ep.2.3h 3.56573515 7.98624447 -1.71630008 3.557328028 -1.70120689
Mi.2.3h -15.32854656 0.35306908 -6.62294904 -1.507820702 7.29314219
Tr.2.3h 3.35580969 0.59840446 1.57230492 3.943570930 5.77994149
Ve.2.3h 20.38926365 12.87334843 -8.14042710 -4.352818996 -9.99907235
Da.2.24h -0.98003447 -1.24907289 -0.25588316 1.668957283 -3.81517809
Do.2.24h -0.12823626 1.23247447 0.28087743 -0.387515936 1.35539607
Ep.2.24h -0.31406495 -0.60806035 0.40253623 0.229084754 0.36009620
Mi.2.24h -2.00896775 -1.58808078 1.66010496 1.398423336 1.63270172
Tr.2.24h -0.61291432 0.16528308 4.79781398 -0.236576132 0.93485042
Ve.2.24h 1.45802749 -2.53730603 -0.89165605 1.205315361 1.34470960
Da.3.3h 13.40508412 -1.01367039 -2.16762008 0.086480341 -2.77484075
Do.3.3h -3.69532801 -2.47998584 0.95329236 5.552073606 9.86050653
Ep.3.3h 4.19535902 2.79656572 5.89423766 -6.766831545 -0.23986634
Mi.3.3h 0.08069762 -2.78923822 7.18438900 -0.387558463 0.27502834
Tr.3.3h 3.72855885 -1.72091315 -3.02883564 -9.552568868 -7.83192688
Ve.3.3h -15.22152266 6.39087579 -8.68161214 8.413747387 -0.54007417
Da.3.24h 0.05958664 0.66991011 1.54216595 2.984692274 -1.40906767
Do.3.24h 0.84801708 -2.19187258 -0.60534344 -1.587477221 0.43590587
Ep.3.24h -0.13736626 1.07167713 -1.19385696 -3.475335100 1.68035561
Mi.3.24h 2.68521988 0.47333375 0.92802961 2.630638441 0.24257817
Tr.3.24h -3.22015495 2.55325170 -0.14904238 0.537331951 -1.06532141
Ve.3.24h -3.28923957 -0.88015311 0.09335863 1.051091591 1.10545807
Da.4.3h -2.35618026 17.59348532 4.51605021 2.161295816 -3.38608491
Do.4.3h -0.43745139 -1.20007268 -1.31840099 -1.657971099 3.57804909
Ep.4.3h -1.10956247 8.27006145 3.29518666 -0.164959161 1.87027280
Mi.4.3h 8.76108018 -4.66619694 -8.46745827 3.438942639 13.83407984
Tr.4.3h -0.04662178 -7.97941001 -0.93003081 -2.490049234 -1.49360827
Ve.4.3h 0.95559220 -15.65147189 5.74397380 2.337739053 -5.94070165
Da.4.24h 2.75213377 2.72555593 -5.01423317 -16.992409587 21.93015840
Do.4.24h -4.59624512 1.82651246 3.56113596 19.197134707 -13.38888900
Ep.4.24h 1.95121904 0.51593559 3.35308116 5.306360723 -5.83543030
Mi.4.24h -0.89371031 -9.85402249 -6.51592160 -16.387149120 -8.13864732
Tr.4.24h -0.83671159 -1.63018587 1.12149907 -2.507773037 -4.40405954
Ve.4.24h -5.01905706 9.55543526 -0.47084992 8.706155295 3.47184295
Da.5.3h -1.36806212 -3.29510544 0.18797548 0.923050371 -0.15289030
Do.5.3h -4.77821882 -1.41791267 2.63319017 0.456697065 0.95688856
Ep.5.3h 3.24681853 4.66817101 -6.92214172 0.818701314 1.88502311
Mi.5.3h 0.16814106 -4.53249234 2.34810073 1.221054206 -2.25514670
Tr.5.3h 0.95874345 2.50319534 0.54007298 1.216300548 -1.01841606
Ve.5.3h 2.01311330 -0.28842555 0.45118881 0.529955407 0.72443486
Da.5.24h 0.79164368 -0.87329887 -0.15726779 -0.919933435 -1.09294267
Do.5.24h 0.72547424 -1.54294994 3.23881686 -0.166628024 0.89389616
Ep.5.24h 1.37019695 2.20881533 -3.15084400 -3.357372553 0.43351136
Mi.5.24h -1.60259090 1.18071693 1.53101478 3.909629368 0.10201615
Tr.5.24h -0.90451297 1.76567730 -0.04833416 0.240401620 2.50377536
Ve.5.24h -0.03022677 -1.25234230 -0.40572611 -4.313127808 -1.77349902
Da.6.3h 0.31400145 6.87953600 1.42627875 -8.160378633 -5.42282168
Do.6.3h -11.68720035 5.64730334 -5.08812260 -3.803372579 -5.12592027
Ep.6.3h 15.08669750 -14.27069896 -6.67267666 16.208131214 5.15527682
Mi.6.3h -0.91826377 3.04119251 -12.11781216 -3.430318782 -12.22017412
Tr.6.3h -0.09776371 -3.62857081 5.03952062 -5.318356558 2.19818519
Ve.6.3h -2.01001657 0.08945834 22.47770342 -1.073160064 12.15261531
Da.6.24h -1.63372294 -3.59455110 -1.54500707 0.002669103 -1.85817336
Do.6.24h -2.06470053 2.96756825 1.91902621 1.222160214 2.28587931
Ep.6.24h -0.27631358 0.49160418 -1.08564626 -0.903097808 0.04955103
Mi.6.24h 4.24074299 0.26527116 0.01886322 2.962617630 0.66516568
Tr.6.24h -0.10182390 1.95526116 -1.10132389 1.286971125 0.82704540
Ve.6.24h -1.24717885 -0.04083679 -2.83862938 -0.646525098 -1.99673436
PC62 PC63 PC64 PC65 PC66
Da.1.3h 3.80225579 3.67374147 3.57822296 -1.42825840 -2.10951590
Do.1.3h -20.95859015 -10.68784988 -6.58861456 -21.02378725 2.42858285
Ep.1.3h -2.82091906 -9.96426331 -2.61244601 13.81515896 8.62783075
Mi.1.3h 9.23377947 10.50448575 7.93881514 1.11092491 -4.62851324
Tr.1.3h 1.61550594 4.00870118 -2.56783258 0.23283340 -0.78659807
Ve.1.3h 5.97322777 4.35449958 -0.49846333 3.44037766 -1.27799700
Da.1.24h 0.25644750 0.73620712 -2.17856071 2.01743344 0.54836874
Do.1.24h 0.19656813 0.08901443 0.16110018 0.07657901 0.10186767
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Mi.1.24h 0.73425145 -9.43848787 6.41248149 1.80326182 -0.22611411
Tr.1.24h 0.88767439 5.39926063 -6.48301861 -4.67069189 -4.95388383
Ve.1.24h 1.73366080 -3.30339382 1.64538151 6.41830968 1.52974653
Da.2.3h 0.40384466 -2.94049222 -1.48010612 -2.00010655 0.27298409
Do.2.3h 16.58320822 -2.20126949 6.20401717 4.59182330 3.25965355
Ep.2.3h -3.81379806 3.01982893 -2.58781483 -1.22216753 1.00222744
Mi.2.3h -5.60308018 1.19769702 -0.28502586 -1.95854150 -3.25126594
Tr.2.3h -2.47425839 0.71588914 -2.92378298 0.43298782 -1.80810232
Ve.2.3h -10.08434997 2.31005579 -1.42350280 0.73610694 3.03280523
Da.2.24h 0.46373035 0.70382854 -1.39665866 0.65979640 -0.23839381
Do.2.24h -0.37981298 -0.35841189 0.06962356 -0.22236472 -0.13430632
Ep.2.24h -0.08175910 0.23785665 -0.34262555 -0.35922096 -0.35918550
Mi.2.24h 1.42377792 -1.66372746 0.76274289 0.36748965 -0.47209189
Tr.2.24h 1.50857433 -0.27981173 -0.13469737 -0.17444100 -1.95385505
Ve.2.24h 1.32941821 -0.35184143 1.75002943 -2.47175154 -0.89057315
Da.3.3h -2.35659930 -2.38191358 0.05844620 0.90893554 -1.60409334
Do.3.3h -7.76922731 8.13476507 -3.08057881 5.74462204 1.63575351
Ep.3.3h 0.49993005 0.81171969 1.07387517 -4.13386007 2.24129039
Mi.3.3h 3.95387316 0.74502534 0.03217004 2.67749649 -0.76514084
Tr.3.3h 19.43414273 -14.68199547 2.75946681 -9.04239952 -9.39166821
Ve.3.3h -6.28469131 3.58147586 1.02133173 3.03507529 3.69647582
Da.3.24h 0.86517807 -0.16784998 -1.53835580 -1.24131555 -0.03052162
Do.3.24h 1.51393481 -0.66084111 1.59122222 -0.32615636 0.88620050
Ep.3.24h -0.86604849 1.52571744 0.90524574 1.13859118 -0.46439766
Mi.3.24h -2.52898004 -4.44095176 -0.42350191 -2.05053507 -0.96705718
Tr.3.24h -8.14508889 5.63306118 0.35417524 2.31663719 6.66470409
Ve.3.24h 0.95874678 1.44846169 -0.37851924 1.72226370 -0.79488474
Da.4.3h 10.65204349 11.37064964 2.14766095 -13.44889877 11.49688439
Do.4.3h -2.15143272 1.26617307 -5.07681891 1.78730864 -16.51635221
Ep.4.3h -6.81987495 -7.15952851 -1.04126067 9.87105884 -21.61563356
Mi.4.3h 6.24569942 -15.69119092 -18.62390504 0.21604913 18.43219423
Tr.4.3h -0.23064968 0.41548822 0.26405249 -0.36709856 -4.41130693
Ve.4.3h -8.61979711 2.12993145 23.78663387 0.23777156 8.65543742
Da.4.24h -2.75783980 -0.18324925 12.39486195 -4.84410104 0.02506907
Do.4.24h 1.62453837 -3.41505328 -9.49022188 4.64766788 -1.91080309
Ep.4.24h -0.63999294 -1.42378817 -0.54370174 -1.97000905 1.48213699
Mi.4.24h 1.75169998 21.72500526 -12.91810180 2.52433453 1.17940872
Tr.4.24h -1.33635424 0.65176881 4.32138624 3.15425247 1.90973628
Ve.4.24h 0.23026212 -8.55322118 4.21417296 -1.58117244 1.25412500
Da.5.3h 1.83767588 -0.64717279 0.34529646 -0.41566315 -0.62159104
Do.5.3h -1.71542431 0.09753056 2.00321424 2.83319119 1.07719892
Ep.5.3h 1.32942316 3.66602501 -1.30832229 -5.33565272 0.03008352
Mi.5.3h -1.99502803 0.33912649 1.74719239 1.91867163 -1.25943236
Tr.5.3h -0.46036394 -0.63263804 0.98066651 -0.22582251 -0.03508588
Ve.5.3h 0.70006789 -1.06201452 -0.99216182 -0.35908907 -0.16874703
Da.5.24h 0.02316001 0.23514015 -0.21757343 -0.14619596 0.60915039
Do.5.24h 1.27229676 0.48636484 0.76915310 0.68657061 0.37217464
Ep.5.24h -1.23627802 -1.70721263 0.49673319 1.02786201 -0.13486128
Mi.5.24h -0.40633160 1.22542435 0.14948341 -0.45394896 -0.04085276
Tr.5.24h -0.24189831 -1.61375480 -1.08278604 -0.07952712 -0.90515348
Ve.5.24h 1.97134728 -0.49830934 -2.65029005 -0.29473763 0.64436499
Da.6.3h -1.17896055 -3.16876805 3.75501674 19.65212036 8.61309843
Do.6.3h 9.42046497 -0.55563205 -1.78069563 -8.76862124 0.92963468
Ep.6.3h 0.08989564 3.50134428 5.38237926 -3.51764881 -0.64439340
Mi.6.3h -7.00849108 -0.61016196 3.59061054 -6.91681428 -3.76086365
Tr.6.3h 0.27231993 -0.57717860 -7.08211858 3.60054519 -5.47910877
Ve.6.3h 0.81569920 7.30227755 -9.49978977 -0.62824908 1.93831907
Da.6.24h 1.04700035 1.81253690 -3.33819986 -0.30993546 -1.89945967
Do.6.24h -1.53489031 0.96577323 1.48454760 -0.81825953 0.63111032
Ep.6.24h -0.36799057 -0.88198149 0.62985230 0.17482759 0.46803208
Mi.6.24h 0.04692564 -3.38152926 4.26821307 -2.31132666 0.35885557
Tr.6.24h -0.72658857 -0.87261678 2.29661594 1.41536544 0.04991347
Ve.6.24h 1.13528469 -1.63600200 0.11391837 -0.74092495 0.37436349
PC67 PC68 PC69 PC70 PC71
Da.1.3h -6.66301818 2.39351377 8.366157e-01 -2.50737192 0.06894936
Do.1.3h -9.71888335 2.05049256 2.287137e+00 -3.22955341 -0.03713247
Ep.1.3h 23.93361211 -4.96121700 -4.814438e+00 6.66858368 -0.14735605
Mi.1.3h -6.40683949 1.07497837 -8.087857e-01 -1.36559720 0.68021313
Tr.1.3h -2.60310888 -0.09251201 1.340132e+00 -1.42778143 -1.20584273
Ve.1.3h 2.15516474 -1.57708979 -9.633441e-01 -1.51849714 -1.53757465
Da.1.24h -0.46915457 0.31299339 -2.379139e-01 0.06165387 0.54290581
Do.1.24h 0.19837379 -0.04825615 8.403137e-04 0.10331735 0.02638455
Ep.1.24h 0.30108818 0.29681709 5.562998e-01 -0.20459263 -0.21778212
Mi.1.24h 2.40304856 -3.52722653 2.785387e+00 -1.71880444 0.90869165
Tr.1.24h -0.16075786 -0.01056379 -1.702859e+00 5.13906212 1.23793202
Ve.1.24h -1.79207065 1.95251026 -9.238909e-01 0.43804795 0.27640715
Da.2.3h 1.00369635 -0.97613679 5.291678e-01 0.18159170 0.54273251
Do.2.3h 0.58369648 2.68156870 2.531156e-01 -1.94683475 -0.02130711
Ep.2.3h -1.37925095 2.49912465 5.304118e-01 -0.53215881 -0.02244123
Mi.2.3h -0.16891490 -2.76462777 -7.080271e-01 0.96911323 -0.47850362
Tr.2.3h 0.08267162 -2.73453097 -1.802997e+00 -1.03314095 -1.19838265
Ve.2.3h 1.53483196 -0.06813837 1.311316e+00 0.28064819 -0.15177909
Da.2.24h -0.02210809 0.68274333 6.576418e-01 -0.12012801 -0.42860554
Do.2.24h 0.63339543 -0.17921060 -1.976179e-01 -0.08998868 0.04018689
Ep.2.24h 0.34674584 0.10775063 7.710309e-02 -0.01749263 -0.17430508
Mi.2.24h -0.29461593 -1.20857348 -9.662102e-01 0.46958074 1.04110672
Tr.2.24h -1.40849014 -0.11593233 -3.096056e-01 2.17543563 -0.06512473
Ve.2.24h 0.30381271 0.67070337 3.909303e-01 0.10330277 0.48752531
Da.3.3h 3.23490432 -0.28474481 -1.154057e+00 -0.18234477 0.51104892
Do.3.3h 3.09939636 -3.99013149 -1.638238e+00 -2.08092923 0.82998657
Ep.3.3h -3.87944912 -2.06823124 -2.674340e+00 0.95382073 0.51146598
Mi.3.3h 0.84499324 -0.44269818 1.182988e+00 -0.17294280 -0.05893414
Tr.3.3h -3.20778494 4.65594461 2.149266e+00 2.96347845 -2.39007148
Ve.3.3h 0.13586062 5.50606894 3.044670e+00 2.57494718 -0.27974666
Da.3.24h -0.53799685 -0.39603756 -5.586343e-01 -0.34342385 -0.02644608
Do.3.24h 0.71294202 0.16968013 7.209402e-01 -1.23762943 0.04373554
Ep.3.24h -0.71659483 0.47717558 1.469513e-02 1.25492850 0.28283404
Mi.3.24h -0.91996656 -3.10916546 9.626991e-01 -1.14542338 0.52642095
Tr.3.24h 2.41063263 1.05249371 -1.949136e+00 -0.64851418 0.79088797
Ve.3.24h -1.19782931 0.25031951 -1.355771e+00 -0.77036522 -0.43906018
Da.4.3h 5.06233839 -6.09369145 -3.492354e+00 -3.65040846 -1.18052908
Do.4.3h -1.12897426 -18.25891308 1.476274e+01 16.62309989 -6.40969194
Ep.4.3h 2.88829359 20.82796458 -8.209494e+00 -6.78611982 -2.31858578
Mi.4.3h -4.53146047 5.39203421 4.337628e-01 -1.10179398 -3.05457871
Tr.4.3h 1.34051052 -7.24226145 -2.288175e+00 -6.44624709 27.74916345
Ve.4.3h -2.31051541 2.31436126 -7.218513e+00 6.95284992 -8.59439864
Da.4.24h 2.01397499 1.02017324 -6.656107e-01 -0.14615489 0.32090638
Do.4.24h -1.48818944 -1.20033563 -1.181242e+00 -0.11862426 -0.89512614
Ep.4.24h -1.34476107 -0.73489232 7.001615e-01 1.13129501 0.26104834
Mi.4.24h -3.93429525 8.37284794 -4.418690e+00 3.30519517 -2.45339886
Tr.4.24h 5.97836427 -0.54308165 2.340989e+01 -20.71381630 -5.58068689
Ve.4.24h -4.12508571 -2.66246924 -8.349903e+00 9.45306973 1.93513681
Da.5.3h 1.37593333 0.84748834 4.591067e-01 -0.17917462 0.47854895
Do.5.3h -2.46384665 -1.52449048 4.052514e-01 -1.82901998 0.78440497
Ep.5.3h -2.22006176 1.20997370 -2.035852e+00 -0.59110231 -0.38054453
Mi.5.3h 2.33844778 -0.76736523 -8.974880e-01 -0.23900680 0.05682015
Tr.5.3h 1.19060002 1.21039323 1.599588e+00 1.79041242 -0.01737017
Ve.5.3h 0.68408997 0.10801576 -2.991127e-01 0.43006730 -0.12527718
Da.5.24h 0.17296116 -0.34866172 -5.427730e-01 -0.41159827 0.38696236
Do.5.24h -0.50195019 0.12097818 6.514638e-02 -0.56446888 -0.20934154
Ep.5.24h 0.03907813 -0.96434395 3.294611e-01 0.09559961 0.14878473
Mi.5.24h 0.51275986 0.39211489 1.178113e-01 -0.16915943 -0.71855445
Tr.5.24h -2.03631062 -0.30007720 -1.515746e+00 2.48443102 1.06765927
Ve.5.24h 1.21748880 0.08512276 2.021129e-01 0.36577144 -0.78625549
Da.6.3h -22.23770151 -1.15523755 6.687260e+00 3.08797698 4.65146962
Do.6.3h 6.72728623 1.96492765 -3.225846e-01 1.98416303 0.24501562
Ep.6.3h 3.15232610 3.38090407 3.054357e+00 -1.55638008 0.23926906
Mi.6.3h 6.47146988 1.30444213 7.086845e-01 1.79138480 0.88441172
Tr.6.3h -4.37605882 -17.39116180 -1.649709e+01 -16.14144265 -10.03863268
Ve.6.3h 6.14202956 10.83372875 8.209262e+00 7.31195869 2.42291408
Da.6.24h 0.36795937 -0.44866388 -8.363085e-01 1.18928686 -0.19547777
Do.6.24h 1.04178115 1.23613263 8.493192e-01 -0.40798680 0.09857072
Ep.6.24h 0.71256370 -0.40136829 5.130911e-01 -1.09880892 0.03324489
Mi.6.24h 1.92971554 0.28594507 1.810848e-01 -0.43107116 0.24733065
Tr.6.24h -1.04500669 1.22214450 1.733116e-01 0.79993204 0.52359211
Ve.6.24h 0.01221315 -0.37253226 -9.559588e-01 1.74189357 -0.04582351
PC72
Da.1.3h 4.512393e-14
Do.1.3h 1.315511e-13
Ep.1.3h 4.959423e-14
Mi.1.3h 2.347384e-14
Tr.1.3h 5.423326e-14
Ve.1.3h 3.646110e-14
Da.1.24h 1.053194e-14
Do.1.24h -2.261542e-13
Ep.1.24h -1.778109e-13
Mi.1.24h 4.606471e-14
Tr.1.24h -3.393878e-15
Ve.1.24h 1.072955e-13
Da.2.3h -1.001827e-13
Do.2.3h 1.436149e-13
Ep.2.3h 5.176849e-14
Mi.2.3h 6.097553e-15
Tr.2.3h 9.089431e-14
Ve.2.3h 1.591284e-14
Da.2.24h 7.332416e-14
Do.2.24h -2.479728e-13
Ep.2.24h 9.008007e-14
Mi.2.24h 2.468566e-14
Tr.2.24h 9.295451e-14
Ve.2.24h -5.146274e-14
Da.3.3h 2.210471e-15
Do.3.3h -6.210760e-14
Ep.3.3h 6.978554e-14
Mi.3.3h 2.978932e-14
Tr.3.3h -5.825960e-14
Ve.3.3h -3.612822e-14
Da.3.24h 2.980385e-14
Do.3.24h -3.927739e-13
Ep.3.24h 1.010693e-13
Mi.3.24h 8.283435e-14
Tr.3.24h 4.463942e-14
Ve.3.24h -1.024014e-13
Da.4.3h 5.394432e-14
Do.4.3h 1.002406e-13
Ep.4.3h 3.454208e-14
Mi.4.3h 5.208139e-14
Tr.4.3h 1.520033e-13
Ve.4.3h 2.204899e-14
Da.4.24h -1.142229e-14
Do.4.24h 4.214060e-13
Ep.4.24h 4.038436e-15
Mi.4.24h 7.513629e-15
Tr.4.24h 6.268791e-14
Ve.4.24h 8.240262e-14
Da.5.3h 4.549312e-14
Do.5.3h -6.507707e-15
Ep.5.3h -7.256934e-14
Mi.5.3h -1.163739e-13
Tr.5.3h 5.421401e-14
Ve.5.3h -8.433689e-14
Da.5.24h 7.626278e-14
Do.5.24h -2.379607e-13
Ep.5.24h -1.686130e-14
Mi.5.24h 3.535843e-14
Tr.5.24h -1.740214e-13
Ve.5.24h 2.024368e-15
Da.6.3h 4.096723e-14
Do.6.3h 8.119438e-14
Ep.6.3h 7.617019e-14
Mi.6.3h 2.413293e-14
Tr.6.3h 3.896558e-14
Ve.6.3h 9.742424e-14
Da.6.24h -8.789779e-14
Do.6.24h -5.884307e-14
Ep.6.24h 2.655098e-15
Mi.6.24h 3.320282e-14
Tr.6.24h -9.472392e-14
Ve.6.24h -7.019125e-16function(pca) {
# x: class == prcomp
pca.var <- pca$sdev^2
pca.prop <- pca.var / sum(pca.var)
var.plot <- qplot(PC, prop, data = data.frame(PC = 1:length(pca.prop),
prop = pca.prop)) +
labs(title = 'Variance contributed by each PC',
x = 'PC', y = 'Proportion of variance')
}Variance contribution from treatment, extraction time, or individual on PC1 and PC2
Warning: Using shapes for an ordinal variable is not advised
Differential Expression
Length Class Mode
coefficients 148230 -none- numeric
stdev.unscaled 148230 -none- numeric
sigma 14823 -none- numeric
df.residual 14823 -none- numeric
cov.coefficients 100 -none- numeric
pivot 12 -none- numeric
rank 1 -none- numeric
genes 2 data.frame list
Amean 14823 -none- numeric
method 1 -none- character
design 864 -none- numeric
contrasts 120 -none- numeric
df.prior 1 -none- numeric
s2.prior 1 -none- numeric
var.prior 10 -none- numeric
proportion 1 -none- numeric
s2.post 14823 -none- numeric
t 148230 -none- numeric
df.total 14823 -none- numeric
p.value 148230 -none- numeric
lods 148230 -none- numeric
F 14823 -none- numeric
F.p.value 14823 -none- numeric mm2 <- model.matrix(~0 + group1)
##made the matrix model using the interaction between Treatment and Time
colnames(mm2) <- c("A3", "X3", "E3","M3","T3", "V3","A24", "X24", "E24","M24","T24", "V24")
y2 <- voom(x, mm2)
corfit2 <- duplicateCorrelation(y2, mm2, block = indv)
v2 <- voom(x, mm2, block = indv, correlation = corfit2$consensus)
fit2 <- lmFit(v2, mm2, block = indv, correlation = corfit2$consensus)
vfit2 <- lmFit(v2, mm2)
vfit2<- contrasts.fit(vfit2, contrasts=cm2)
efit2 <- eBayes(vfit2)
V.DA.top= topTable(efit2, coef=1, adjust="BH", number=Inf, sort.by="p")
### sorting all top expressed genes for the Vehicle and Daunorubicin 3 hour treatments
sigVDA3 = V.DA.top[V.DA.top$adj.P.Val < .1 , ]
### this helped pull only those files that were at an adjusted p value of less than 0.1
### This p-value was used as the beginning examination of the data, considering I will run multiple runs of this RNA seq library.This is the example code I used to process my data. I used two model matrix initially, one set up was /~0 +drug +time and the second was /~0+group1, then blocking by individual. That is why you see the number 2 in the code above.
#DEG summary
Importance of components:
PC1 PC2 PC3 PC4 PC5 PC6
Standard deviation 60.2067 44.5108 32.3037 30.98489 27.1431 24.07762
Proportion of Variance 0.2445 0.1337 0.0704 0.06477 0.0497 0.03911
Cumulative Proportion 0.2445 0.3782 0.4486 0.51337 0.5631 0.60218
PC7 PC8 PC9 PC10 PC11 PC12
Standard deviation 23.26775 21.37712 20.13091 18.19509 17.63059 16.30004
Proportion of Variance 0.03652 0.03083 0.02734 0.02233 0.02097 0.01792
Cumulative Proportion 0.63870 0.66953 0.69687 0.71921 0.74018 0.75810
PC13 PC14 PC15 PC16 PC17 PC18
Standard deviation 15.87695 14.24554 13.51806 12.67177 11.84085 11.44481
Proportion of Variance 0.01701 0.01369 0.01233 0.01083 0.00946 0.00884
Cumulative Proportion 0.77511 0.78880 0.80113 0.81196 0.82142 0.83025
PC19 PC20 PC21 PC22 PC23 PC24 PC25
Standard deviation 11.08484 10.4711 9.86347 9.53287 9.25138 9.06027 8.70778
Proportion of Variance 0.00829 0.0074 0.00656 0.00613 0.00577 0.00554 0.00512
Cumulative Proportion 0.83854 0.8459 0.85250 0.85863 0.86441 0.86995 0.87506
PC26 PC27 PC28 PC29 PC30 PC31 PC32
Standard deviation 8.40220 8.26732 8.04037 7.85926 7.76676 7.67958 7.48930
Proportion of Variance 0.00476 0.00461 0.00436 0.00417 0.00407 0.00398 0.00378
Cumulative Proportion 0.87982 0.88444 0.88880 0.89296 0.89703 0.90101 0.90480
PC33 PC34 PC35 PC36 PC37 PC38 PC39
Standard deviation 7.34178 7.28566 7.22861 7.1043 6.99972 6.94542 6.83650
Proportion of Variance 0.00364 0.00358 0.00353 0.0034 0.00331 0.00325 0.00315
Cumulative Proportion 0.90843 0.91201 0.91554 0.9189 0.92225 0.92550 0.92866
PC40 PC41 PC42 PC43 PC44 PC45 PC46
Standard deviation 6.75717 6.73038 6.57835 6.54307 6.53123 6.4395 6.37432
Proportion of Variance 0.00308 0.00306 0.00292 0.00289 0.00288 0.0028 0.00274
Cumulative Proportion 0.93174 0.93479 0.93771 0.94060 0.94348 0.9463 0.94902
PC47 PC48 PC49 PC50 PC51 PC52 PC53
Standard deviation 6.34772 6.23190 6.17748 6.0816 6.01946 5.9644 5.89730
Proportion of Variance 0.00272 0.00262 0.00257 0.0025 0.00244 0.0024 0.00235
Cumulative Proportion 0.95173 0.95435 0.95693 0.9594 0.96187 0.9643 0.96661
PC54 PC55 PC56 PC57 PC58 PC59 PC60
Standard deviation 5.8378 5.80173 5.72099 5.69367 5.65008 5.60128 5.47568
Proportion of Variance 0.0023 0.00227 0.00221 0.00219 0.00215 0.00212 0.00202
Cumulative Proportion 0.9689 0.97118 0.97339 0.97558 0.97773 0.97985 0.98187
PC61 PC62 PC63 PC64 PC65 PC66 PC67
Standard deviation 5.46660 5.38710 5.31872 5.25710 5.11760 5.0166 4.83245
Proportion of Variance 0.00202 0.00196 0.00191 0.00186 0.00177 0.0017 0.00158
Cumulative Proportion 0.98389 0.98585 0.98776 0.98962 0.99139 0.9931 0.99466
PC68 PC69 PC70 PC71 PC72
Standard deviation 4.73475 4.57831 4.51242 3.92680 4.923e-14
Proportion of Variance 0.00151 0.00141 0.00137 0.00104 0.000e+00
Cumulative Proportion 0.99617 0.99759 0.99896 1.00000 1.000e+00 V.DA V.DX V.EP V.MT V.TR V.DA24 V.DX24 V.EP24 V.MT24 V.TR24
Down 63 3 11 13 0 3342 3013 2871 320 0
NotSig 14456 14814 14714 14780 14823 8279 8993 9034 13970 14823
Up 304 6 98 30 0 3202 2817 2918 533 0Graphing DE genes
I then created a counts table for each set of genes. Luckily, the counts are stored in the y2 object, which is an EList class object. I can ‘simplify’ this process because I kept the DEGList format initially. I first made an object called ‘countstotal’ from the EList y2. For ggploting later, I subsetted ‘countstotal’ by treatments.
library(cowplot)
Volcano Plots
GO analysis
R version 4.2.2 (2022-10-31 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)
Matrix products: default
locale:
[1] LC_COLLATE=English_United States.utf8
[2] LC_CTYPE=English_United States.utf8
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C
[5] LC_TIME=English_United States.utf8
attached base packages:
[1] stats4 stats graphics grDevices utils datasets methods
[8] base
other attached packages:
[1] pheatmap_1.0.12
[2] ggfortify_0.4.16
[3] Hmisc_5.1-0
[4] corrplot_0.92
[5] ggrepel_0.9.3
[6] cowplot_1.1.1
[7] Homo.sapiens_1.3.1
[8] TxDb.Hsapiens.UCSC.hg19.knownGene_3.2.2
[9] org.Hs.eg.db_3.15.0
[10] GO.db_3.15.0
[11] OrganismDbi_1.38.1
[12] GenomicFeatures_1.48.4
[13] GenomicRanges_1.48.0
[14] GenomeInfoDb_1.32.4
[15] AnnotationDbi_1.58.0
[16] IRanges_2.30.1
[17] S4Vectors_0.34.0
[18] Biobase_2.56.0
[19] biomaRt_2.52.0
[20] scales_1.2.1
[21] lubridate_1.9.2
[22] forcats_1.0.0
[23] stringr_1.5.0
[24] dplyr_1.1.2
[25] purrr_1.0.1
[26] readr_2.1.4
[27] tidyr_1.3.0
[28] tibble_3.2.1
[29] tidyverse_2.0.0
[30] AnnotationHub_3.4.0
[31] BiocFileCache_2.4.0
[32] dbplyr_2.3.2
[33] BiocGenerics_0.42.0
[34] devtools_2.4.5
[35] usethis_2.2.0
[36] reshape2_1.4.4
[37] gridExtra_2.3
[38] mixOmics_6.20.0
[39] ggplot2_3.4.2
[40] lattice_0.21-8
[41] MASS_7.3-60
[42] RColorBrewer_1.1-3
[43] edgeR_3.38.4
[44] limma_3.52.4
[45] workflowr_1.7.0
loaded via a namespace (and not attached):
[1] utf8_1.2.3 tidyselect_1.2.0
[3] RSQLite_2.3.1 htmlwidgets_1.6.2
[5] grid_4.2.2 BiocParallel_1.30.4
[7] munsell_0.5.0 codetools_0.2-19
[9] statmod_1.5.0 miniUI_0.1.1.1
[11] withr_2.5.0 colorspace_2.1-0
[13] filelock_1.0.2 highr_0.10
[15] knitr_1.43 rstudioapi_0.14
[17] MatrixGenerics_1.8.1 labeling_0.4.2
[19] git2r_0.32.0 GenomeInfoDbData_1.2.8
[21] bit64_4.0.5 farver_2.1.1
[23] rprojroot_2.0.3 vctrs_0.6.3
[25] generics_0.1.3 xfun_0.39
[27] timechange_0.2.0 R6_2.5.1
[29] locfit_1.5-9.8 bitops_1.0-7
[31] cachem_1.0.8 DelayedArray_0.22.0
[33] promises_1.2.0.1 BiocIO_1.6.0
[35] vroom_1.6.3 nnet_7.3-19
[37] gtable_0.3.3 processx_3.8.1
[39] rlang_1.1.1 rtracklayer_1.56.1
[41] checkmate_2.2.0 BiocManager_1.30.21
[43] yaml_2.3.7 backports_1.4.1
[45] httpuv_1.6.11 RBGL_1.72.0
[47] tools_4.2.2 ellipsis_0.3.2
[49] jquerylib_0.1.4 sessioninfo_1.2.2
[51] Rcpp_1.0.10 plyr_1.8.8
[53] base64enc_0.1-3 progress_1.2.2
[55] zlibbioc_1.42.0 RCurl_1.98-1.12
[57] ps_1.7.5 prettyunits_1.1.1
[59] rpart_4.1.19 urlchecker_1.0.1
[61] SummarizedExperiment_1.26.1 cluster_2.1.4
[63] fs_1.6.2 magrittr_2.0.3
[65] data.table_1.14.8 RSpectra_0.16-1
[67] whisker_0.4.1 matrixStats_1.0.0
[69] pkgload_1.3.2 hms_1.1.3
[71] mime_0.12 evaluate_0.21
[73] xtable_1.8-4 XML_3.99-0.14
[75] compiler_4.2.2 ellipse_0.4.5
[77] crayon_1.5.2 htmltools_0.5.5
[79] corpcor_1.6.10 later_1.3.1
[81] tzdb_0.4.0 Formula_1.2-5
[83] DBI_1.1.3 rappdirs_0.3.3
[85] Matrix_1.5-4.1 cli_3.6.1
[87] parallel_4.2.2 igraph_1.4.3
[89] pkgconfig_2.0.3 getPass_0.2-2
[91] GenomicAlignments_1.32.1 foreign_0.8-84
[93] xml2_1.3.4 rARPACK_0.11-0
[95] bslib_0.5.0 XVector_0.36.0
[97] callr_3.7.3 digest_0.6.31
[99] graph_1.74.0 Biostrings_2.64.1
[101] rmarkdown_2.22 htmlTable_2.4.1
[103] restfulr_0.0.15 curl_5.0.1
[105] shiny_1.7.4 Rsamtools_2.12.0
[107] rjson_0.2.21 lifecycle_1.0.3
[109] jsonlite_1.8.5 viridisLite_0.4.2
[111] fansi_1.0.4 pillar_1.9.0
[113] KEGGREST_1.36.3 fastmap_1.1.1
[115] httr_1.4.6 pkgbuild_1.4.1
[117] interactiveDisplayBase_1.34.0 glue_1.6.2
[119] remotes_2.4.2 png_0.1-8
[121] BiocVersion_3.15.2 bit_4.0.5
[123] stringi_1.7.12 sass_0.4.6
[125] profvis_0.3.8 blob_1.2.4
[127] memoise_2.0.1