Figure1
ERM
2023-06-15
Last updated: 2023-06-15
Checks: 5 2
Knit directory: Cardiotoxicity/
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| Rmd | 1ebf470 | reneeisnowhere | 2023-06-12 | adding figure 1 |
Figure 1
Top2i drugs affect cardiomyocyte viability in a dose dependent manner.
A. Project Overview
things to note about this image so far: Need to import into illustrator. Goal is to have colors changes on Drugs from sick purple and jaundice yellow, to a red tone and a blue tone for non-ACs. I also want to change to add a time line of treatment.
B. Example Dose response curves from 48 hour drug exposure.
Lines are a log-logistic regression of the mean from quadruplicates at 8 separate concentrations for each condition, except (trastuzmab)TRZ, which is 7 concentrations.
C:/Program Files/R_WD/Cardiotoxicity/output
{30%}
C 48 hour 50% leathal dose plot
library(car)
#library(dr4pl) no longer used
library(tidyverse)
library(tinytex)
library(BiocGenerics)
library(data.table)
library(drc)
# library(Hmisc)
# library(cowplot)
# library(grid)
library(ggsignif)
library(RColorBrewer)
library(broom)
sessionInfo()R version 4.2.2 (2022-10-31 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)
Matrix products: default
locale:
[1] LC_COLLATE=English_United States.utf8
[2] LC_CTYPE=English_United States.utf8
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C
[5] LC_TIME=English_United States.utf8
attached base packages:
[1] stats graphics grDevices utils datasets methods base
other attached packages:
[1] broom_1.0.5 RColorBrewer_1.1-3 ggsignif_0.6.4
[4] drc_3.0-1 MASS_7.3-60 data.table_1.14.8
[7] BiocGenerics_0.42.0 tinytex_0.45 lubridate_1.9.2
[10] forcats_1.0.0 stringr_1.5.0 dplyr_1.1.2
[13] purrr_1.0.1 readr_2.1.4 tidyr_1.3.0
[16] tibble_3.2.1 ggplot2_3.4.2 tidyverse_2.0.0
[19] car_3.1-2 carData_3.0-5 workflowr_1.7.0
loaded via a namespace (and not attached):
[1] httr_1.4.6 sass_0.4.6 jsonlite_1.8.5 splines_4.2.2
[5] gtools_3.9.4 bslib_0.5.0 getPass_0.2-2 highr_0.10
[9] yaml_2.3.7 pillar_1.9.0 backports_1.4.1 lattice_0.21-8
[13] glue_1.6.2 digest_0.6.31 promises_1.2.0.1 colorspace_2.1-0
[17] sandwich_3.0-2 htmltools_0.5.5 httpuv_1.6.11 Matrix_1.5-4.1
[21] pkgconfig_2.0.3 mvtnorm_1.2-2 scales_1.2.1 processx_3.8.1
[25] whisker_0.4.1 later_1.3.1 tzdb_0.4.0 timechange_0.2.0
[29] git2r_0.32.0 generics_0.1.3 TH.data_1.1-2 cachem_1.0.8
[33] withr_2.5.0 cli_3.6.1 survival_3.5-5 magrittr_2.0.3
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