GO and KEGG pathway analysis
ERM
2024-06-07
Last updated: 2024-06-07
Checks: 7 0
Knit directory: ATAC_learning/
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| File | Version | Author | Date | Message |
|---|---|---|---|---|
| Rmd | 95e0415 | reneeisnowhere | 2024-06-07 | updates, i think |
| html | eea0976 | reneeisnowhere | 2024-06-03 | Build site. |
| Rmd | 0672654 | reneeisnowhere | 2024-06-03 | updates to gene lists |
| html | 897af23 | reneeisnowhere | 2024-05-28 | Build site. |
| Rmd | 5c6ef83 | reneeisnowhere | 2024-05-28 | updates to KEGG/GO 20kb lists |
| html | d1a3829 | reneeisnowhere | 2024-05-17 | Build site. |
| Rmd | 9fb4f9a | reneeisnowhere | 2024-05-17 | adding in updates from Neargenes and enhncers |
| html | 2d991d7 | reneeisnowhere | 2024-05-03 | Build site. |
| Rmd | f57f2ee | reneeisnowhere | 2024-05-03 | first update |
library(tidyverse)
# library(ggsignif)
# library(cowplot)
# library(ggpubr)
# library(sjmisc)
library(kableExtra)
library(broom)
# library(biomaRt)
library(RColorBrewer)
library(gprofiler2)
# library(qvalue)
library(ChIPseeker)
library("TxDb.Hsapiens.UCSC.hg38.knownGene")
library("org.Hs.eg.db")
# library(ATACseqQC)
library(rtracklayer)
library(edgeR)
library(ggfortify)
library(limma)
library(readr)
library(BiocGenerics)
library(gridExtra)
library(VennDiagram)
library(scales)
# library(ggVennDiagram)
# library(Cormotif)
library(BiocParallel)
library(ggpubr)
# library(devtools)
# # install_github('davetang/bedr')
# library(bedr)
library(biomaRt)
library(clusterProfiler)data loading
peakAnnoList_n45_motif <- readRDS("data/peakAnnoList_n45_motif.RDS")
# list2env(peakAnnoList_n45_motif, envir = .GlobalEnv)
EAR_df <- as.data.frame(peakAnnoList_n45_motif$EAR_n45_gr)
EAR_df_gr <- GRanges(EAR_df)
ESR_df <- as.data.frame(peakAnnoList_n45_motif$ESR_n45_gr)
ESR_df_gr <- GRanges(ESR_df)
LR_df <- as.data.frame(peakAnnoList_n45_motif$LR_n45_gr)
LR_df_gr <- GRanges(LR_df)
NR_df <- as.data.frame(peakAnnoList_n45_motif$NR_n45_gr)
NR_df_gr <- GRanges(NR_df)
exp_neargene_table <- read_delim("data/n45_bedfiles/exp_neargene_table.tsv",
delim = "\t", escape_double = FALSE,
trim_ws = TRUE)
# col_ng_peak <- exp_neargene_table %>%
# group_by(chr, start, end, peakid) %>%
# summarise(NCBI_gene = paste(unique(ENTREZID),collapse=","),
# ensembl_ID= paste(unique(ensembl_id),collapse = ","),
# SYMBOL= paste(unique(SYMBOL),collapse = ",") ,
# dist_to_NG =min(dist_to_NG))
#
EAR_NG_list <- exp_neargene_table %>%
dplyr::filter(peakid %in% EAR_df$id) %>%
dplyr::filter(dist_to_NG<20000) %>%
dplyr::select(ENTREZID) %>%
distinct()
ESR_NG_list <- exp_neargene_table %>%
dplyr::filter(peakid %in% ESR_df$id) %>%
dplyr::filter(dist_to_NG<20000) %>%
dplyr::select(ENTREZID) %>%
distinct()
LR_NG_list <- exp_neargene_table %>%
dplyr::filter(peakid %in% LR_df$id) %>%
dplyr::filter(dist_to_NG<20000) %>%
dplyr::select(ENTREZID) %>%
distinct()
NR_NG_list <- exp_neargene_table %>%
dplyr::filter(peakid %in% NR_df$id) %>%
dplyr::filter(dist_to_NG<20000) %>%
dplyr::select(ENTREZID) %>%
distinct()
background_df <- exp_neargene_table %>%
dplyr::select(ENTREZID) %>%
distinct()
EAR_resgenes <- readRDS("data/GO_KEGG_analysis/EAR_resgenes.RDS")
ESR_resgenes <- readRDS("data/GO_KEGG_analysis/ESR_resgenes.RDS")
LR_resgenes <- readRDS("data/GO_KEGG_analysis/LR_resgenes.RDS")
NR_resgenes <- readRDS("data/GO_KEGG_analysis/NR_resgenes.RDS")
EAR_enh_peaks_20k <- readRDS("data/enhancerdata/EAR_enh_peaks_20k.RDS")
ESR_enh_peaks_20k <- readRDS("data/enhancerdata/ESR_enh_peaks_20k.RDS")
LR_enh_peaks_20k <- readRDS("data/enhancerdata/LR_enh_peaks_20k.RDS")
NR_enh_peaks_20k <- readRDS("data/enhancerdata/NR_enh_peaks_20k.RDS")
EAR_resgenes_20k <- readRDS("data/GO_KEGG_analysis/EAR_resgenes_20k.RDS")
EAR_resgenes_20k_enh <- readRDS("data/GO_KEGG_analysis/EAR_resgenes_20k_enh.RDS")
ESR_resgenes_20k <- readRDS("data/GO_KEGG_analysis/ESR_resgenes_20k.RDS")
ESR_resgenes_20k_enh <- readRDS("data/GO_KEGG_analysis/ESR_resgenes_20k_enh.RDS")
LR_resgenes_20k <- readRDS("data/GO_KEGG_analysis/LR_resgenes_20k.RDS")
LR_resgenes_20k_enh <- readRDS("data/GO_KEGG_analysis/LR_resgenes_20k_enh.RDS")
NR_resgenes_20k <- readRDS("data/GO_KEGG_analysis/NR_resgenes_20k.RDS")
NR_resgenes_20k_enh <- readRDS("data/GO_KEGG_analysis/NR_resgenes_20k_enh.RDS")
### intersection of peaks files
S13Table <- read.csv( "data/other_papers/S13Table_Matthews2024.csv",row.names = 1)
##14021
EAR_RNA <- S13Table %>%
dplyr::filter(MOTIF=="EAR") %>%
dplyr::select(ENTREZID) %>%
mutate(ENTREZID= as.character(ENTREZID))
ESR_RNA <- S13Table %>%
dplyr::filter(MOTIF=="ESR")%>%
dplyr::select(ENTREZID)%>%
mutate(ENTREZID= as.character(ENTREZID))
LR_RNA <- S13Table %>%
dplyr::filter(MOTIF=="LR")%>%
dplyr::select(ENTREZID)%>%
mutate(ENTREZID=as.character(ENTREZID))
NR_RNA <- S13Table %>%
dplyr::filter(MOTIF=="NR")%>%
dplyr::select(ENTREZID)%>%
mutate(ENTREZID= as.character(ENTREZID))
Resp_RNA <- EAR_RNA %>%
rbind(.,ESR_RNA) %>%
rbind(., LR_RNA) %>%
distinct(ENTREZID)
int_EAR_n_RNAresp <- intersect(EAR_NG_list$ENTREZID, Resp_RNA$ENTREZID)
int_ESR_n_RNAresp <- intersect(ESR_NG_list$ENTREZID, Resp_RNA$ENTREZID)
int_LR_n_RNAresp <- intersect(LR_NG_list$ENTREZID, Resp_RNA$ENTREZID)
int_NR_n_RNAresp <- intersect(NR_NG_list$ENTREZID, Resp_RNA$ENTREZID)
EAR_int_resgenes <- readRDS("data/GO_KEGG_analysis/EAR_int_resgenes.RDS")
ESR_int_resgenes <- readRDS("data/GO_KEGG_analysis/ESR_int_resgenes.RDS")
LR_int_resgenes <- readRDS("data/GO_KEGG_analysis/LR_int_resgenes.RDS")EAR response genes
# EAR_resgenes <- gost(query = EAR_NG_list$ENTREZID,
# organism = "hsapiens",
# significant = FALSE,
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = background_df$ENTREZID,
# sources=c("GO:BP","KEGG"))
# saveRDS(EAR_resgenes,"data/GO_KEGG_analysis/EAR_resgenes.RDS")
# EARnom <- gostplot(EAR_resgenes, capped = FALSE, interactive = TRUE)
# EARnom
EARnomtable <- EAR_resgenes$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
EARnomtable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in EAR neargenes" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 898 | 1844 | 4.11e-28 |
| GO:BP | GO:0032502 | developmental process | 1806 | 4179 | 6.83e-26 |
| GO:BP | GO:0048856 | anatomical structure development | 1683 | 3867 | 2.86e-25 |
| GO:BP | GO:0007275 | multicellular organism development | 1413 | 3170 | 3.48e-25 |
| GO:BP | GO:0032501 | multicellular organismal process | 1918 | 4504 | 2.88e-24 |
| GO:BP | GO:0048869 | cellular developmental process | 1262 | 2804 | 8.92e-24 |
| GO:BP | GO:0030154 | cell differentiation | 1261 | 2803 | 1.02e-23 |
| GO:BP | GO:0050793 | regulation of developmental process | 809 | 1697 | 7.18e-22 |
| GO:BP | GO:0048731 | system development | 1211 | 2719 | 1.94e-20 |
| GO:BP | GO:0016477 | cell migration | 515 | 1011 | 3.91e-20 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 890 | 1924 | 1.81e-19 |
| GO:BP | GO:0007154 | cell communication | 1686 | 3983 | 1.59e-18 |
| GO:BP | GO:0023052 | signaling | 1660 | 3918 | 2.46e-18 |
| GO:BP | GO:0048699 | generation of neurons | 535 | 1076 | 3.58e-18 |
| GO:BP | GO:0040012 | regulation of locomotion | 380 | 720 | 1.16e-17 |
| GO:BP | GO:0030334 | regulation of cell migration | 357 | 668 | 1.16e-17 |
| GO:BP | GO:2000145 | regulation of cell motility | 371 | 700 | 1.19e-17 |
| GO:BP | GO:0048870 | cell motility | 549 | 1120 | 4.10e-17 |
| GO:BP | GO:0009887 | animal organ morphogenesis | 357 | 673 | 4.96e-17 |
| GO:BP | GO:0007165 | signal transduction | 1534 | 3611 | 5.22e-17 |
| GO:BP | GO:0022008 | neurogenesis | 602 | 1251 | 8.71e-17 |
| GO:BP | GO:0040011 | locomotion | 413 | 805 | 1.25e-16 |
| GO:BP | GO:0072359 | circulatory system development | 438 | 864 | 1.52e-16 |
| GO:BP | GO:0030182 | neuron differentiation | 500 | 1014 | 4.14e-16 |
| GO:BP | GO:0048513 | animal organ development | 901 | 2004 | 1.36e-15 |
| GO:BP | GO:0050789 | regulation of biological process | 2957 | 7516 | 2.09e-15 |
| GO:BP | GO:0009888 | tissue development | 634 | 1348 | 4.41e-15 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | 469 | 951 | 4.83e-15 |
| GO:BP | GO:0051094 | positive regulation of developmental process | 452 | 913 | 8.19e-15 |
| GO:BP | GO:0050794 | regulation of cellular process | 2823 | 7153 | 8.19e-15 |
| GO:BP | GO:0065007 | biological regulation | 3028 | 7734 | 1.41e-14 |
| GO:BP | GO:0045595 | regulation of cell differentiation | 517 | 1073 | 2.39e-14 |
| GO:BP | GO:0051716 | cellular response to stimulus | 1900 | 4640 | 4.73e-14 |
| GO:BP | GO:0048468 | cell development | 845 | 1886 | 4.95e-14 |
| GO:BP | GO:0048519 | negative regulation of biological process | 1571 | 3764 | 4.95e-14 |
| GO:BP | GO:0007155 | cell adhesion | 460 | 941 | 5.94e-14 |
| GO:BP | GO:0007399 | nervous system development | 800 | 1775 | 6.41e-14 |
| GO:BP | GO:0009790 | embryo development | 409 | 821 | 6.86e-14 |
| GO:BP | GO:0050896 | response to stimulus | 2170 | 5379 | 1.18e-13 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 1486 | 3550 | 1.59e-13 |
| GO:BP | GO:0035239 | tube morphogenesis | 328 | 638 | 3.14e-13 |
| GO:BP | GO:0048518 | positive regulation of biological process | 1766 | 4301 | 3.91e-13 |
| GO:BP | GO:0035295 | tube development | 391 | 787 | 5.10e-13 |
| GO:BP | GO:0034330 | cell junction organization | 286 | 545 | 7.88e-13 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | 411 | 837 | 9.46e-13 |
| GO:BP | GO:0007423 | sensory organ development | 215 | 387 | 1.12e-12 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 1631 | 3954 | 1.57e-12 |
| GO:BP | GO:0010646 | regulation of cell communication | 1054 | 2444 | 1.80e-12 |
| GO:BP | GO:0048666 | neuron development | 408 | 838 | 5.95e-12 |
| GO:BP | GO:0003008 | system process | 532 | 1139 | 7.86e-12 |
| GO:BP | GO:0023051 | regulation of signaling | 1047 | 2438 | 8.93e-12 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | 302 | 591 | 9.93e-12 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | 309 | 609 | 1.58e-11 |
| GO:BP | GO:0031175 | neuron projection development | 366 | 743 | 1.67e-11 |
| GO:BP | GO:0035556 | intracellular signal transduction | 854 | 1951 | 2.38e-11 |
| GO:BP | GO:0009966 | regulation of signal transduction | 938 | 2166 | 2.52e-11 |
| GO:BP | GO:0048598 | embryonic morphogenesis | 226 | 422 | 3.57e-11 |
| GO:BP | GO:0141124 | intracellular signaling cassette | 599 | 1314 | 4.36e-11 |
| GO:BP | GO:0000902 | cell morphogenesis | 351 | 713 | 5.76e-11 |
| GO:BP | GO:0001501 | skeletal system development | 191 | 347 | 9.68e-11 |
| GO:BP | GO:0001944 | vasculature development | 280 | 552 | 2.24e-10 |
| GO:BP | GO:0051093 | negative regulation of developmental process | 310 | 622 | 2.24e-10 |
| GO:BP | GO:0030900 | forebrain development | 155 | 272 | 3.85e-10 |
| GO:BP | GO:0001568 | blood vessel development | 267 | 525 | 5.12e-10 |
| GO:BP | GO:0031344 | regulation of cell projection organization | 262 | 516 | 1.02e-09 |
| GO:BP | GO:0065008 | regulation of biological quality | 820 | 1893 | 1.15e-09 |
| GO:BP | GO:0120035 | regulation of plasma membrane bounded cell projection organization | 257 | 505 | 1.15e-09 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | 784 | 1801 | 1.15e-09 |
| GO:BP | GO:0010975 | regulation of neuron projection development | 191 | 355 | 1.34e-09 |
| GO:BP | GO:0060429 | epithelium development | 377 | 792 | 2.17e-09 |
| GO:BP | GO:0007507 | heart development | 253 | 499 | 2.66e-09 |
| GO:BP | GO:0048514 | blood vessel morphogenesis | 231 | 450 | 4.42e-09 |
| GO:BP | GO:0007267 | cell-cell signaling | 494 | 1082 | 4.64e-09 |
| GO:BP | GO:0007417 | central nervous system development | 334 | 694 | 6.43e-09 |
| GO:BP | GO:0048589 | developmental growth | 252 | 501 | 7.88e-09 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 802 | 1862 | 7.88e-09 |
| GO:BP | GO:0048729 | tissue morphogenesis | 231 | 453 | 9.50e-09 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | 475 | 1040 | 1.03e-08 |
| GO:BP | GO:0048812 | neuron projection morphogenesis | 242 | 479 | 1.06e-08 |
| GO:BP | GO:0030155 | regulation of cell adhesion | 254 | 508 | 1.35e-08 |
| GO:BP | GO:0001503 | ossification | 164 | 302 | 1.35e-08 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 1130 | 2717 | 1.35e-08 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 472 | 1035 | 1.47e-08 |
| GO:BP | GO:0034329 | cell junction assembly | 173 | 323 | 1.74e-08 |
| GO:BP | GO:0120039 | plasma membrane bounded cell projection morphogenesis | 247 | 494 | 2.33e-08 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | 494 | 1093 | 2.57e-08 |
| GO:BP | GO:0030030 | cell projection organization | 529 | 1182 | 3.41e-08 |
| GO:BP | GO:0048858 | cell projection morphogenesis | 248 | 498 | 3.42e-08 |
| GO:BP | GO:0014706 | striated muscle tissue development | 122 | 213 | 3.92e-08 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | 228 | 452 | 4.03e-08 |
| GO:BP | GO:0060322 | head development | 265 | 539 | 4.21e-08 |
| GO:BP | GO:0070848 | response to growth factor | 268 | 547 | 5.16e-08 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | 116 | 201 | 5.44e-08 |
| GO:BP | GO:0048667 | cell morphogenesis involved in neuron differentiation | 220 | 435 | 5.88e-08 |
| GO:BP | GO:0010647 | positive regulation of cell communication | 541 | 1218 | 7.89e-08 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | 338 | 717 | 8.14e-08 |
| GO:BP | GO:0023056 | positive regulation of signaling | 542 | 1221 | 8.33e-08 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | 513 | 1150 | 1.06e-07 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | 258 | 528 | 1.43e-07 |
| GO:BP | GO:0007420 | brain development | 245 | 498 | 1.69e-07 |
| GO:BP | GO:0061061 | muscle structure development | 261 | 536 | 1.72e-07 |
| GO:BP | GO:0043583 | ear development | 91 | 151 | 1.85e-07 |
| GO:BP | GO:0048880 | sensory system development | 144 | 266 | 1.96e-07 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | 282 | 588 | 2.55e-07 |
| GO:BP | GO:0090596 | sensory organ morphogenesis | 101 | 173 | 2.72e-07 |
| GO:BP | GO:0001525 | angiogenesis | 194 | 381 | 2.81e-07 |
| GO:BP | GO:0001654 | eye development | 142 | 263 | 3.07e-07 |
| GO:BP | GO:0030336 | negative regulation of cell migration | 118 | 210 | 3.07e-07 |
| GO:BP | GO:2000146 | negative regulation of cell motility | 121 | 217 | 3.59e-07 |
| GO:BP | GO:0150063 | visual system development | 142 | 264 | 4.21e-07 |
| GO:BP | GO:0002062 | chondrocyte differentiation | 59 | 88 | 4.53e-07 |
| GO:BP | GO:0001667 | ameboidal-type cell migration | 177 | 344 | 4.89e-07 |
| GO:BP | GO:0060284 | regulation of cell development | 273 | 570 | 5.02e-07 |
| GO:BP | GO:0051216 | cartilage development | 87 | 145 | 5.09e-07 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 527 | 1197 | 5.36e-07 |
| GO:BP | GO:0010631 | epithelial cell migration | 132 | 243 | 6.17e-07 |
| GO:BP | GO:0090132 | epithelium migration | 132 | 243 | 6.17e-07 |
| GO:BP | GO:0098609 | cell-cell adhesion | 270 | 564 | 6.20e-07 |
| GO:BP | GO:0040007 | growth | 325 | 697 | 6.25e-07 |
| GO:BP | GO:0001764 | neuron migration | 79 | 129 | 6.61e-07 |
| GO:BP | GO:0060537 | muscle tissue development | 174 | 339 | 7.73e-07 |
| GO:BP | GO:0050808 | synapse organization | 173 | 337 | 8.34e-07 |
| GO:BP | GO:0003013 | circulatory system process | 211 | 426 | 9.64e-07 |
| GO:BP | GO:0008283 | cell population proliferation | 568 | 1306 | 1.06e-06 |
| GO:BP | GO:0042221 | response to chemical | 955 | 2304 | 1.08e-06 |
| GO:BP | GO:0040013 | negative regulation of locomotion | 131 | 243 | 1.22e-06 |
| GO:BP | GO:0002009 | morphogenesis of an epithelium | 186 | 369 | 1.35e-06 |
| GO:BP | GO:0007409 | axonogenesis | 172 | 337 | 1.51e-06 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | 560 | 1289 | 1.56e-06 |
| GO:BP | GO:0048839 | inner ear development | 80 | 133 | 1.56e-06 |
| GO:BP | GO:0061564 | axon development | 187 | 372 | 1.56e-06 |
| GO:BP | GO:0060021 | roof of mouth development | 48 | 69 | 1.71e-06 |
| GO:BP | GO:0051241 | negative regulation of multicellular organismal process | 326 | 706 | 1.89e-06 |
| GO:BP | GO:0090130 | tissue migration | 132 | 247 | 2.04e-06 |
| GO:BP | GO:0016358 | dendrite development | 103 | 183 | 2.18e-06 |
| GO:BP | GO:0010632 | regulation of epithelial cell migration | 105 | 188 | 2.76e-06 |
| GO:BP | GO:2000147 | positive regulation of cell motility | 201 | 408 | 3.29e-06 |
| GO:BP | GO:0040017 | positive regulation of locomotion | 204 | 416 | 4.07e-06 |
| GO:BP | GO:0030335 | positive regulation of cell migration | 195 | 395 | 4.26e-06 |
| GO:BP | GO:0030029 | actin filament-based process | 297 | 640 | 4.36e-06 |
| GO:BP | GO:0044057 | regulation of system process | 190 | 384 | 5.04e-06 |
| GO:BP | GO:0048568 | embryonic organ development | 155 | 303 | 5.70e-06 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | 472 | 1077 | 6.07e-06 |
| GO:BP | GO:0048732 | gland development | 157 | 308 | 6.25e-06 |
| GO:BP | GO:0003007 | heart morphogenesis | 117 | 218 | 8.62e-06 |
| GO:BP | GO:0061448 | connective tissue development | 111 | 205 | 9.75e-06 |
| GO:BP | GO:0048705 | skeletal system morphogenesis | 85 | 148 | 9.75e-06 |
| GO:BP | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 219 | 456 | 1.01e-05 |
| GO:BP | GO:0016055 | Wnt signaling pathway | 177 | 358 | 1.44e-05 |
| GO:BP | GO:0007389 | pattern specification process | 146 | 286 | 1.52e-05 |
| GO:BP | GO:0043408 | regulation of MAPK cascade | 206 | 427 | 1.53e-05 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | 732 | 1751 | 1.58e-05 |
| GO:BP | GO:0198738 | cell-cell signaling by wnt | 177 | 359 | 1.79e-05 |
| GO:BP | GO:0007264 | small GTPase-mediated signal transduction | 190 | 390 | 1.90e-05 |
| GO:BP | GO:0060411 | cardiac septum morphogenesis | 45 | 67 | 2.05e-05 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 985 | 2415 | 2.05e-05 |
| GO:BP | GO:0043010 | camera-type eye development | 121 | 230 | 2.05e-05 |
| GO:BP | GO:0007411 | axon guidance | 95 | 172 | 2.13e-05 |
| GO:BP | GO:0097485 | neuron projection guidance | 95 | 172 | 2.13e-05 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | 635 | 1504 | 2.24e-05 |
| GO:BP | GO:0060560 | developmental growth involved in morphogenesis | 103 | 190 | 2.32e-05 |
| GO:BP | GO:0051173 | positive regulation of nitrogen compound metabolic process | 897 | 2186 | 2.42e-05 |
| GO:BP | GO:0010033 | response to organic substance | 724 | 1736 | 2.71e-05 |
| GO:BP | GO:0021537 | telencephalon development | 105 | 195 | 2.73e-05 |
| GO:BP | GO:0030111 | regulation of Wnt signaling pathway | 134 | 261 | 2.87e-05 |
| GO:BP | GO:0050807 | regulation of synapse organization | 95 | 173 | 2.92e-05 |
| GO:BP | GO:0009952 | anterior/posterior pattern specification | 71 | 121 | 2.99e-05 |
| GO:BP | GO:0051146 | striated muscle cell differentiation | 122 | 234 | 3.23e-05 |
| GO:BP | GO:0016043 | cellular component organization | 1874 | 4802 | 3.24e-05 |
| GO:BP | GO:0050803 | regulation of synapse structure or activity | 96 | 176 | 3.77e-05 |
| GO:BP | GO:0001649 | osteoblast differentiation | 95 | 174 | 4.04e-05 |
| GO:BP | GO:0009987 | cellular process | 3975 | 10686 | 4.12e-05 |
| GO:BP | GO:0042692 | muscle cell differentiation | 160 | 323 | 4.12e-05 |
| GO:BP | GO:0050877 | nervous system process | 275 | 600 | 4.21e-05 |
| GO:BP | GO:0031589 | cell-substrate adhesion | 132 | 258 | 4.23e-05 |
| GO:BP | GO:0048588 | developmental cell growth | 97 | 179 | 4.75e-05 |
| GO:BP | GO:0034762 | regulation of transmembrane transport | 149 | 298 | 4.85e-05 |
| GO:BP | GO:0008015 | blood circulation | 174 | 357 | 5.05e-05 |
| GO:BP | GO:0050890 | cognition | 112 | 213 | 5.11e-05 |
| GO:BP | GO:0000165 | MAPK cascade | 235 | 504 | 5.53e-05 |
| GO:BP | GO:0045785 | positive regulation of cell adhesion | 150 | 301 | 5.61e-05 |
| GO:BP | GO:0035265 | organ growth | 73 | 127 | 5.74e-05 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 1939 | 4988 | 5.76e-05 |
| GO:BP | GO:0099536 | synaptic signaling | 226 | 483 | 6.35e-05 |
| GO:BP | GO:0035313 | wound healing, spreading of epidermal cells | 16 | 17 | 6.38e-05 |
| GO:BP | GO:0006468 | protein phosphorylation | 417 | 958 | 7.02e-05 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | 1057 | 2622 | 7.62e-05 |
| GO:BP | GO:0045664 | regulation of neuron differentiation | 74 | 130 | 7.84e-05 |
| GO:BP | GO:0045444 | fat cell differentiation | 96 | 179 | 9.34e-05 |
| GO:BP | GO:0010648 | negative regulation of cell communication | 446 | 1034 | 9.54e-05 |
| GO:BP | GO:0048592 | eye morphogenesis | 63 | 107 | 9.78e-05 |
| GO:BP | GO:0051960 | regulation of nervous system development | 165 | 339 | 9.94e-05 |
| GO:BP | GO:0048638 | regulation of developmental growth | 124 | 243 | 9.94e-05 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | 373 | 850 | 1.00e-04 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | 219 | 469 | 1.06e-04 |
| GO:BP | GO:0048762 | mesenchymal cell differentiation | 105 | 200 | 1.12e-04 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | 252 | 550 | 1.14e-04 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | 382 | 874 | 1.18e-04 |
| GO:BP | GO:0071310 | cellular response to organic substance | 548 | 1297 | 1.20e-04 |
| GO:BP | GO:0009792 | embryo development ending in birth or egg hatching | 240 | 521 | 1.20e-04 |
| GO:BP | GO:0072001 | renal system development | 124 | 244 | 1.25e-04 |
| GO:BP | GO:0051056 | regulation of small GTPase mediated signal transduction | 119 | 233 | 1.44e-04 |
| GO:BP | GO:0023057 | negative regulation of signaling | 445 | 1036 | 1.58e-04 |
| GO:BP | GO:0035051 | cardiocyte differentiation | 74 | 132 | 1.58e-04 |
| GO:BP | GO:0030855 | epithelial cell differentiation | 201 | 428 | 1.66e-04 |
| GO:BP | GO:0099537 | trans-synaptic signaling | 217 | 467 | 1.71e-04 |
| GO:BP | GO:0099177 | regulation of trans-synaptic signaling | 157 | 323 | 1.82e-04 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | 334 | 757 | 1.87e-04 |
| GO:BP | GO:0010720 | positive regulation of cell development | 151 | 309 | 1.89e-04 |
| GO:BP | GO:0060412 | ventricular septum morphogenesis | 29 | 40 | 1.92e-04 |
| GO:BP | GO:0045637 | regulation of myeloid cell differentiation | 75 | 135 | 2.07e-04 |
| GO:BP | GO:0050673 | epithelial cell proliferation | 147 | 300 | 2.07e-04 |
| GO:BP | GO:0031346 | positive regulation of cell projection organization | 141 | 286 | 2.13e-04 |
| GO:BP | GO:0003002 | regionalization | 129 | 258 | 2.19e-04 |
| GO:BP | GO:0055007 | cardiac muscle cell differentiation | 61 | 105 | 2.32e-04 |
| GO:BP | GO:0010810 | regulation of cell-substrate adhesion | 87 | 162 | 2.32e-04 |
| GO:BP | GO:0050804 | modulation of chemical synaptic transmission | 156 | 322 | 2.36e-04 |
| GO:BP | GO:0045165 | cell fate commitment | 82 | 151 | 2.42e-04 |
| GO:BP | GO:0060828 | regulation of canonical Wnt signaling pathway | 105 | 203 | 2.45e-04 |
| GO:BP | GO:0007369 | gastrulation | 77 | 140 | 2.47e-04 |
| GO:BP | GO:0050770 | regulation of axonogenesis | 70 | 125 | 2.83e-04 |
| GO:BP | GO:0043009 | chordate embryonic development | 232 | 507 | 2.89e-04 |
| GO:BP | GO:0051049 | regulation of transport | 467 | 1098 | 2.89e-04 |
| GO:BP | GO:1903706 | regulation of hemopoiesis | 128 | 257 | 2.92e-04 |
| GO:BP | GO:0035107 | appendage morphogenesis | 63 | 110 | 2.96e-04 |
| GO:BP | GO:0035108 | limb morphogenesis | 63 | 110 | 2.96e-04 |
| GO:BP | GO:0050767 | regulation of neurogenesis | 142 | 290 | 2.96e-04 |
| GO:BP | GO:0003206 | cardiac chamber morphogenesis | 63 | 110 | 2.96e-04 |
| GO:BP | GO:0042592 | homeostatic process | 482 | 1137 | 3.01e-04 |
| GO:BP | GO:0022612 | gland morphogenesis | 55 | 93 | 3.04e-04 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | 124 | 248 | 3.09e-04 |
| GO:BP | GO:0043410 | positive regulation of MAPK cascade | 141 | 288 | 3.14e-04 |
| GO:BP | GO:1902533 | positive regulation of intracellular signal transduction | 315 | 714 | 3.22e-04 |
| GO:BP | GO:0007610 | behavior | 196 | 420 | 3.22e-04 |
| GO:BP | GO:0002063 | chondrocyte development | 19 | 23 | 3.51e-04 |
| GO:BP | GO:0008150 | biological_process | 4156 | 11244 | 3.65e-04 |
| GO:BP | GO:0016049 | cell growth | 180 | 382 | 3.65e-04 |
| GO:BP | GO:0065009 | regulation of molecular function | 544 | 1299 | 3.81e-04 |
| GO:BP | GO:0048562 | embryonic organ morphogenesis | 95 | 182 | 3.84e-04 |
| GO:BP | GO:0099175 | regulation of postsynapse organization | 49 | 81 | 3.87e-04 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | 255 | 566 | 3.90e-04 |
| GO:BP | GO:0007611 | learning or memory | 98 | 189 | 3.97e-04 |
| GO:BP | GO:0002761 | regulation of myeloid leukocyte differentiation | 48 | 79 | 3.98e-04 |
| GO:BP | GO:0045667 | regulation of osteoblast differentiation | 57 | 98 | 4.00e-04 |
| GO:BP | GO:0007268 | chemical synaptic transmission | 213 | 463 | 4.07e-04 |
| GO:BP | GO:0098916 | anterograde trans-synaptic signaling | 213 | 463 | 4.07e-04 |
| GO:BP | GO:0048813 | dendrite morphogenesis | 63 | 111 | 4.09e-04 |
| GO:BP | GO:0030097 | hemopoiesis | 278 | 624 | 4.34e-04 |
| GO:BP | GO:0003281 | ventricular septum development | 43 | 69 | 4.57e-04 |
| GO:BP | GO:0010633 | negative regulation of epithelial cell migration | 34 | 51 | 4.71e-04 |
| GO:BP | GO:0031325 | positive regulation of cellular metabolic process | 938 | 2333 | 4.73e-04 |
| GO:BP | GO:0060041 | retina development in camera-type eye | 60 | 105 | 4.89e-04 |
| GO:BP | GO:0099173 | postsynapse organization | 79 | 147 | 5.18e-04 |
| GO:BP | GO:0060173 | limb development | 74 | 136 | 5.42e-04 |
| GO:BP | GO:0048736 | appendage development | 74 | 136 | 5.42e-04 |
| GO:BP | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 69 | 125 | 5.53e-04 |
| GO:BP | GO:0021953 | central nervous system neuron differentiation | 57 | 99 | 5.80e-04 |
| GO:BP | GO:0001822 | kidney development | 118 | 237 | 5.92e-04 |
| GO:BP | GO:0022604 | regulation of cell morphogenesis | 99 | 193 | 6.04e-04 |
| GO:BP | GO:2001222 | regulation of neuron migration | 27 | 38 | 6.25e-04 |
| GO:BP | GO:0060070 | canonical Wnt signaling pathway | 120 | 242 | 6.32e-04 |
| GO:BP | GO:0070372 | regulation of ERK1 and ERK2 cascade | 91 | 175 | 6.56e-04 |
| GO:BP | GO:0008360 | regulation of cell shape | 60 | 106 | 7.00e-04 |
| GO:BP | GO:0060348 | bone development | 78 | 146 | 7.47e-04 |
| GO:BP | GO:0050772 | positive regulation of axonogenesis | 40 | 64 | 7.85e-04 |
| GO:BP | GO:0003279 | cardiac septum development | 58 | 102 | 7.85e-04 |
| GO:BP | GO:0055017 | cardiac muscle tissue growth | 40 | 64 | 7.85e-04 |
| GO:BP | GO:0021543 | pallium development | 73 | 135 | 7.85e-04 |
| GO:BP | GO:0035113 | embryonic appendage morphogenesis | 51 | 87 | 7.88e-04 |
| GO:BP | GO:0030326 | embryonic limb morphogenesis | 51 | 87 | 7.88e-04 |
| GO:BP | GO:0006811 | monoatomic ion transport | 314 | 719 | 7.89e-04 |
| GO:BP | GO:0016310 | phosphorylation | 481 | 1145 | 8.12e-04 |
| GO:BP | GO:0048645 | animal organ formation | 34 | 52 | 8.12e-04 |
| GO:BP | GO:0003205 | cardiac chamber development | 80 | 151 | 8.43e-04 |
| GO:BP | GO:0032879 | regulation of localization | 594 | 1439 | 9.38e-04 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | 413 | 972 | 9.46e-04 |
| GO:BP | GO:0032924 | activin receptor signaling pathway | 24 | 33 | 9.46e-04 |
| GO:BP | GO:0042476 | odontogenesis | 47 | 79 | 9.46e-04 |
| GO:BP | GO:1901888 | regulation of cell junction assembly | 82 | 156 | 9.60e-04 |
| GO:BP | GO:0031399 | regulation of protein modification process | 389 | 911 | 9.67e-04 |
| GO:BP | GO:0002521 | leukocyte differentiation | 173 | 371 | 9.70e-04 |
| GO:BP | GO:0030198 | extracellular matrix organization | 111 | 223 | 9.80e-04 |
| GO:BP | GO:0050678 | regulation of epithelial cell proliferation | 122 | 249 | 1.01e-03 |
| GO:BP | GO:0007416 | synapse assembly | 73 | 136 | 1.03e-03 |
| GO:BP | GO:0008038 | neuron recognition | 25 | 35 | 1.03e-03 |
| GO:BP | GO:0060562 | epithelial tube morphogenesis | 127 | 261 | 1.04e-03 |
| GO:BP | GO:0071407 | cellular response to organic cyclic compound | 176 | 379 | 1.08e-03 |
| GO:BP | GO:1990138 | neuron projection extension | 72 | 134 | 1.10e-03 |
| GO:BP | GO:0070169 | positive regulation of biomineral tissue development | 26 | 37 | 1.11e-03 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | 126 | 259 | 1.12e-03 |
| GO:BP | GO:0048663 | neuron fate commitment | 20 | 26 | 1.15e-03 |
| GO:BP | GO:0060485 | mesenchyme development | 120 | 245 | 1.16e-03 |
| GO:BP | GO:0045778 | positive regulation of ossification | 27 | 39 | 1.18e-03 |
| GO:BP | GO:0034220 | monoatomic ion transmembrane transport | 260 | 587 | 1.18e-03 |
| GO:BP | GO:0090100 | positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 50 | 86 | 1.18e-03 |
| GO:BP | GO:0043062 | extracellular structure organization | 111 | 224 | 1.19e-03 |
| GO:BP | GO:0045229 | external encapsulating structure organization | 111 | 224 | 1.19e-03 |
| GO:BP | GO:0022029 | telencephalon cell migration | 28 | 41 | 1.22e-03 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | 388 | 911 | 1.22e-03 |
| GO:BP | GO:0007612 | learning | 61 | 110 | 1.23e-03 |
| GO:BP | GO:0021885 | forebrain cell migration | 29 | 43 | 1.26e-03 |
| GO:BP | GO:0048660 | regulation of smooth muscle cell proliferation | 55 | 97 | 1.27e-03 |
| GO:BP | GO:1903522 | regulation of blood circulation | 98 | 194 | 1.27e-03 |
| GO:BP | GO:0045666 | positive regulation of neuron differentiation | 36 | 57 | 1.29e-03 |
| GO:BP | GO:0044319 | wound healing, spreading of cells | 21 | 28 | 1.32e-03 |
| GO:BP | GO:0090505 | epiboly involved in wound healing | 21 | 28 | 1.32e-03 |
| GO:BP | GO:0014070 | response to organic cyclic compound | 267 | 606 | 1.40e-03 |
| GO:BP | GO:0043269 | regulation of monoatomic ion transport | 135 | 282 | 1.49e-03 |
| GO:BP | GO:0060996 | dendritic spine development | 45 | 76 | 1.49e-03 |
| GO:BP | GO:0001823 | mesonephros development | 44 | 74 | 1.57e-03 |
| GO:BP | GO:0001508 | action potential | 57 | 102 | 1.58e-03 |
| GO:BP | GO:0045995 | regulation of embryonic development | 43 | 72 | 1.63e-03 |
| GO:BP | GO:0001657 | ureteric bud development | 43 | 72 | 1.63e-03 |
| GO:BP | GO:0030501 | positive regulation of bone mineralization | 23 | 32 | 1.67e-03 |
| GO:BP | GO:0072073 | kidney epithelium development | 61 | 111 | 1.67e-03 |
| GO:BP | GO:0048593 | camera-type eye morphogenesis | 50 | 87 | 1.67e-03 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | 511 | 1231 | 1.67e-03 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | 209 | 463 | 1.67e-03 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | 209 | 463 | 1.67e-03 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | 512 | 1234 | 1.72e-03 |
| GO:BP | GO:0030879 | mammary gland development | 55 | 98 | 1.76e-03 |
| GO:BP | GO:0010717 | regulation of epithelial to mesenchymal transition | 49 | 85 | 1.76e-03 |
| GO:BP | GO:0021795 | cerebral cortex cell migration | 24 | 34 | 1.81e-03 |
| GO:BP | GO:0031345 | negative regulation of cell projection organization | 76 | 145 | 1.84e-03 |
| GO:BP | GO:0086003 | cardiac muscle cell contraction | 39 | 64 | 1.87e-03 |
| GO:BP | GO:0045216 | cell-cell junction organization | 79 | 152 | 1.92e-03 |
| GO:BP | GO:0033002 | muscle cell proliferation | 79 | 152 | 1.92e-03 |
| GO:BP | GO:0010463 | mesenchymal cell proliferation | 25 | 36 | 1.92e-03 |
| GO:BP | GO:0034765 | regulation of monoatomic ion transmembrane transport | 104 | 210 | 1.94e-03 |
| GO:BP | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 104 | 210 | 1.94e-03 |
| GO:BP | GO:0040008 | regulation of growth | 208 | 462 | 2.02e-03 |
| GO:BP | GO:0070371 | ERK1 and ERK2 cascade | 97 | 194 | 2.12e-03 |
| GO:BP | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 31 | 48 | 2.21e-03 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | 557 | 1354 | 2.22e-03 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | 841 | 2100 | 2.23e-03 |
| GO:BP | GO:0072164 | mesonephric tubule development | 43 | 73 | 2.39e-03 |
| GO:BP | GO:0048706 | embryonic skeletal system development | 43 | 73 | 2.39e-03 |
| GO:BP | GO:0072163 | mesonephric epithelium development | 43 | 73 | 2.39e-03 |
| GO:BP | GO:0009611 | response to wounding | 175 | 382 | 2.44e-03 |
| GO:BP | GO:0060419 | heart growth | 42 | 71 | 2.51e-03 |
| GO:BP | GO:0043542 | endothelial cell migration | 88 | 174 | 2.64e-03 |
| GO:BP | GO:0035270 | endocrine system development | 48 | 84 | 2.68e-03 |
| GO:BP | GO:0030001 | metal ion transport | 232 | 524 | 2.76e-03 |
| GO:BP | GO:0031214 | biomineral tissue development | 58 | 106 | 2.76e-03 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | 141 | 300 | 2.76e-03 |
| GO:BP | GO:0150115 | cell-substrate junction organization | 53 | 95 | 2.76e-03 |
| GO:BP | GO:0048675 | axon extension | 53 | 95 | 2.76e-03 |
| GO:BP | GO:0090504 | epiboly | 21 | 29 | 2.77e-03 |
| GO:BP | GO:0003231 | cardiac ventricle development | 62 | 115 | 2.81e-03 |
| GO:BP | GO:0003170 | heart valve development | 39 | 65 | 2.83e-03 |
| GO:BP | GO:0060571 | morphogenesis of an epithelial fold | 13 | 15 | 2.91e-03 |
| GO:BP | GO:0045598 | regulation of fat cell differentiation | 52 | 93 | 2.92e-03 |
| GO:BP | GO:0008284 | positive regulation of cell population proliferation | 264 | 605 | 3.00e-03 |
| GO:BP | GO:0007517 | muscle organ development | 127 | 267 | 3.09e-03 |
| GO:BP | GO:0031328 | positive regulation of cellular biosynthetic process | 741 | 1841 | 3.11e-03 |
| GO:BP | GO:0055006 | cardiac cell development | 45 | 78 | 3.12e-03 |
| GO:BP | GO:0044093 | positive regulation of molecular function | 334 | 783 | 3.20e-03 |
| GO:BP | GO:0033993 | response to lipid | 251 | 573 | 3.25e-03 |
| GO:BP | GO:0051179 | localization | 1448 | 3731 | 3.27e-03 |
| GO:BP | GO:0018210 | peptidyl-threonine modification | 44 | 76 | 3.28e-03 |
| GO:BP | GO:0051057 | positive regulation of small GTPase mediated signal transduction | 34 | 55 | 3.34e-03 |
| GO:BP | GO:0002573 | myeloid leukocyte differentiation | 78 | 152 | 3.34e-03 |
| GO:BP | GO:0003179 | heart valve morphogenesis | 34 | 55 | 3.34e-03 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | 493 | 1193 | 3.36e-03 |
| GO:BP | GO:1905207 | regulation of cardiocyte differentiation | 17 | 22 | 3.42e-03 |
| GO:BP | GO:0042471 | ear morphogenesis | 43 | 74 | 3.43e-03 |
| GO:BP | GO:1902105 | regulation of leukocyte differentiation | 96 | 194 | 3.44e-03 |
| GO:BP | GO:0098660 | inorganic ion transmembrane transport | 230 | 521 | 3.45e-03 |
| GO:BP | GO:0006812 | monoatomic cation transport | 267 | 614 | 3.47e-03 |
| GO:BP | GO:0050680 | negative regulation of epithelial cell proliferation | 54 | 98 | 3.48e-03 |
| GO:BP | GO:1990090 | cellular response to nerve growth factor stimulus | 27 | 41 | 3.56e-03 |
| GO:BP | GO:0055013 | cardiac muscle cell development | 42 | 72 | 3.56e-03 |
| GO:BP | GO:1990089 | response to nerve growth factor | 27 | 41 | 3.56e-03 |
| GO:BP | GO:0010812 | negative regulation of cell-substrate adhesion | 27 | 41 | 3.56e-03 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | 721 | 1791 | 3.65e-03 |
| GO:BP | GO:0031324 | negative regulation of cellular metabolic process | 775 | 1934 | 3.77e-03 |
| GO:BP | GO:0032409 | regulation of transporter activity | 76 | 148 | 3.81e-03 |
| GO:BP | GO:0022407 | regulation of cell-cell adhesion | 131 | 278 | 3.83e-03 |
| GO:BP | GO:0003015 | heart process | 100 | 204 | 3.83e-03 |
| GO:BP | GO:0046328 | regulation of JNK cascade | 57 | 105 | 3.83e-03 |
| GO:BP | GO:0001704 | formation of primary germ layer | 52 | 94 | 3.93e-03 |
| GO:BP | GO:0003272 | endocardial cushion formation | 18 | 24 | 3.95e-03 |
| GO:BP | GO:0007160 | cell-matrix adhesion | 85 | 169 | 3.95e-03 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | 646 | 1595 | 3.95e-03 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | 745 | 1856 | 4.05e-03 |
| GO:BP | GO:0034764 | positive regulation of transmembrane transport | 68 | 130 | 4.06e-03 |
| GO:BP | GO:0035115 | embryonic forelimb morphogenesis | 14 | 17 | 4.09e-03 |
| GO:BP | GO:0048659 | smooth muscle cell proliferation | 55 | 101 | 4.39e-03 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | 453 | 1093 | 4.47e-03 |
| GO:BP | GO:0030177 | positive regulation of Wnt signaling pathway | 59 | 110 | 4.47e-03 |
| GO:BP | GO:0010092 | specification of animal organ identity | 19 | 26 | 4.47e-03 |
| GO:BP | GO:0051962 | positive regulation of nervous system development | 103 | 212 | 4.57e-03 |
| GO:BP | GO:0097435 | supramolecular fiber organization | 273 | 633 | 5.34e-03 |
| GO:BP | GO:0060323 | head morphogenesis | 21 | 30 | 5.36e-03 |
| GO:BP | GO:0048546 | digestive tract morphogenesis | 21 | 30 | 5.36e-03 |
| GO:BP | GO:0150146 | cell junction disassembly | 15 | 19 | 5.39e-03 |
| GO:BP | GO:0003156 | regulation of animal organ formation | 15 | 19 | 5.39e-03 |
| GO:BP | GO:0035137 | hindlimb morphogenesis | 15 | 19 | 5.39e-03 |
| GO:BP | GO:0035136 | forelimb morphogenesis | 15 | 19 | 5.39e-03 |
| GO:BP | GO:0042327 | positive regulation of phosphorylation | 186 | 415 | 5.43e-03 |
| GO:BP | GO:0016331 | morphogenesis of embryonic epithelium | 64 | 122 | 5.45e-03 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | 31 | 50 | 5.59e-03 |
| GO:BP | GO:0098655 | monoatomic cation transmembrane transport | 218 | 495 | 5.59e-03 |
| GO:BP | GO:0018107 | peptidyl-threonine phosphorylation | 40 | 69 | 5.73e-03 |
| GO:BP | GO:0002065 | columnar/cuboidal epithelial cell differentiation | 46 | 82 | 5.73e-03 |
| GO:BP | GO:0003197 | endocardial cushion development | 29 | 46 | 5.84e-03 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | 28 | 44 | 5.93e-03 |
| GO:BP | GO:0019827 | stem cell population maintenance | 73 | 143 | 5.95e-03 |
| GO:BP | GO:0010596 | negative regulation of endothelial cell migration | 25 | 38 | 5.95e-03 |
| GO:BP | GO:0048013 | ephrin receptor signaling pathway | 25 | 38 | 5.95e-03 |
| GO:BP | GO:0007632 | visual behavior | 26 | 40 | 5.95e-03 |
| GO:BP | GO:0003151 | outflow tract morphogenesis | 39 | 67 | 5.95e-03 |
| GO:BP | GO:0031290 | retinal ganglion cell axon guidance | 12 | 14 | 5.95e-03 |
| GO:BP | GO:2000725 | regulation of cardiac muscle cell differentiation | 12 | 14 | 5.95e-03 |
| GO:BP | GO:0010634 | positive regulation of epithelial cell migration | 66 | 127 | 6.02e-03 |
| GO:BP | GO:0030856 | regulation of epithelial cell differentiation | 54 | 100 | 6.25e-03 |
| GO:BP | GO:0030282 | bone mineralization | 44 | 78 | 6.42e-03 |
| GO:BP | GO:0014912 | negative regulation of smooth muscle cell migration | 16 | 21 | 6.43e-03 |
| GO:BP | GO:0007492 | endoderm development | 37 | 63 | 6.61e-03 |
| GO:BP | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 132 | 284 | 6.86e-03 |
| GO:BP | GO:0010586 | miRNA metabolic process | 48 | 87 | 6.89e-03 |
| GO:BP | GO:0110020 | regulation of actomyosin structure organization | 48 | 87 | 6.89e-03 |
| GO:BP | GO:0022898 | regulation of transmembrane transporter activity | 71 | 139 | 6.89e-03 |
| GO:BP | GO:0018193 | peptidyl-amino acid modification | 241 | 555 | 7.16e-03 |
| GO:BP | GO:0060840 | artery development | 47 | 85 | 7.38e-03 |
| GO:BP | GO:0061337 | cardiac conduction | 47 | 85 | 7.38e-03 |
| GO:BP | GO:0031128 | developmental induction | 17 | 23 | 7.40e-03 |
| GO:BP | GO:0098662 | inorganic cation transmembrane transport | 211 | 480 | 7.52e-03 |
| GO:BP | GO:1901342 | regulation of vasculature development | 96 | 198 | 7.53e-03 |
| GO:BP | GO:0008016 | regulation of heart contraction | 82 | 165 | 7.56e-03 |
| GO:BP | GO:0030099 | myeloid cell differentiation | 135 | 292 | 7.61e-03 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | 41 | 72 | 7.62e-03 |
| GO:BP | GO:0048863 | stem cell differentiation | 93 | 191 | 7.66e-03 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | 777 | 1951 | 7.69e-03 |
| GO:BP | GO:0050769 | positive regulation of neurogenesis | 90 | 184 | 7.80e-03 |
| GO:BP | GO:1905208 | negative regulation of cardiocyte differentiation | 10 | 11 | 7.80e-03 |
| GO:BP | GO:0038180 | nerve growth factor signaling pathway | 10 | 11 | 7.80e-03 |
| GO:BP | GO:0071560 | cellular response to transforming growth factor beta stimulus | 103 | 215 | 7.92e-03 |
| GO:BP | GO:0046777 | protein autophosphorylation | 72 | 142 | 7.98e-03 |
| GO:BP | GO:1903689 | regulation of wound healing, spreading of epidermal cells | 8 | 8 | 7.98e-03 |
| GO:BP | GO:0060993 | kidney morphogenesis | 39 | 68 | 8.53e-03 |
| GO:BP | GO:0060047 | heart contraction | 94 | 194 | 8.66e-03 |
| GO:BP | GO:0018105 | peptidyl-serine phosphorylation | 80 | 161 | 8.69e-03 |
| GO:BP | GO:0001952 | regulation of cell-matrix adhesion | 49 | 90 | 8.69e-03 |
| GO:BP | GO:0010464 | regulation of mesenchymal cell proliferation | 19 | 27 | 8.72e-03 |
| GO:BP | GO:0060325 | face morphogenesis | 19 | 27 | 8.72e-03 |
| GO:BP | GO:0060998 | regulation of dendritic spine development | 30 | 49 | 8.73e-03 |
| GO:BP | GO:0042063 | gliogenesis | 114 | 242 | 8.74e-03 |
| GO:BP | GO:0030278 | regulation of ossification | 44 | 79 | 8.76e-03 |
| GO:BP | GO:0007010 | cytoskeleton organization | 470 | 1146 | 8.83e-03 |
| GO:BP | GO:0001570 | vasculogenesis | 38 | 66 | 8.90e-03 |
| GO:BP | GO:0051017 | actin filament bundle assembly | 67 | 131 | 9.03e-03 |
| GO:BP | GO:0043087 | regulation of GTPase activity | 82 | 166 | 9.17e-03 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | 48 | 88 | 9.17e-03 |
| GO:BP | GO:0048565 | digestive tract development | 48 | 88 | 9.17e-03 |
| GO:BP | GO:0098727 | maintenance of cell number | 73 | 145 | 9.21e-03 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | 338 | 805 | 9.24e-03 |
| GO:BP | GO:0060038 | cardiac muscle cell proliferation | 27 | 43 | 9.39e-03 |
| GO:BP | GO:0006915 | apoptotic process | 558 | 1377 | 9.44e-03 |
| GO:BP | GO:0010171 | body morphogenesis | 26 | 41 | 9.55e-03 |
| GO:BP | GO:0021536 | diencephalon development | 25 | 39 | 9.68e-03 |
| GO:BP | GO:0048511 | rhythmic process | 105 | 221 | 9.69e-03 |
| GO:BP | GO:0008542 | visual learning | 23 | 35 | 9.69e-03 |
| GO:BP | GO:0010594 | regulation of endothelial cell migration | 69 | 136 | 9.76e-03 |
| GO:BP | GO:0010811 | positive regulation of cell-substrate adhesion | 51 | 95 | 9.95e-03 |
| GO:BP | GO:0051234 | establishment of localization | 1257 | 3240 | 1.01e-02 |
| GO:BP | GO:0008219 | cell death | 575 | 1423 | 1.03e-02 |
| GO:BP | GO:0042472 | inner ear morphogenesis | 35 | 60 | 1.03e-02 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | 35 | 60 | 1.03e-02 |
| GO:BP | GO:0071559 | response to transforming growth factor beta | 104 | 219 | 1.03e-02 |
| GO:BP | GO:0060349 | bone morphogenesis | 41 | 73 | 1.04e-02 |
| GO:BP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 58 | 111 | 1.04e-02 |
| GO:BP | GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 68 | 134 | 1.04e-02 |
| GO:BP | GO:1904062 | regulation of monoatomic cation transmembrane transport | 91 | 188 | 1.04e-02 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | 337 | 804 | 1.05e-02 |
| GO:BP | GO:0021987 | cerebral cortex development | 50 | 93 | 1.05e-02 |
| GO:BP | GO:0051896 | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 88 | 181 | 1.06e-02 |
| GO:BP | GO:0051147 | regulation of muscle cell differentiation | 61 | 118 | 1.07e-02 |
| GO:BP | GO:0007186 | G protein-coupled receptor signaling pathway | 172 | 386 | 1.10e-02 |
| GO:BP | GO:0001934 | positive regulation of protein phosphorylation | 176 | 396 | 1.10e-02 |
| GO:BP | GO:0061572 | actin filament bundle organization | 67 | 132 | 1.12e-02 |
| GO:BP | GO:0043368 | positive T cell selection | 15 | 20 | 1.18e-02 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | 128 | 278 | 1.18e-02 |
| GO:BP | GO:0022030 | telencephalon glial cell migration | 15 | 20 | 1.18e-02 |
| GO:BP | GO:0099560 | synaptic membrane adhesion | 15 | 20 | 1.18e-02 |
| GO:BP | GO:0021801 | cerebral cortex radial glia-guided migration | 15 | 20 | 1.18e-02 |
| GO:BP | GO:0086065 | cell communication involved in cardiac conduction | 32 | 54 | 1.18e-02 |
| GO:BP | GO:0042475 | odontogenesis of dentin-containing tooth | 32 | 54 | 1.18e-02 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | 121 | 261 | 1.18e-02 |
| GO:BP | GO:0007398 | ectoderm development | 11 | 13 | 1.19e-02 |
| GO:BP | GO:0031032 | actomyosin structure organization | 89 | 184 | 1.19e-02 |
| GO:BP | GO:0006814 | sodium ion transport | 69 | 137 | 1.20e-02 |
| GO:BP | GO:0002040 | sprouting angiogenesis | 52 | 98 | 1.20e-02 |
| GO:BP | GO:0001837 | epithelial to mesenchymal transition | 69 | 137 | 1.20e-02 |
| GO:BP | GO:0007015 | actin filament organization | 160 | 357 | 1.20e-02 |
| GO:BP | GO:0045669 | positive regulation of osteoblast differentiation | 31 | 52 | 1.22e-02 |
| GO:BP | GO:0003012 | muscle system process | 147 | 325 | 1.22e-02 |
| GO:BP | GO:0048878 | chemical homeostasis | 284 | 670 | 1.23e-02 |
| GO:BP | GO:0061035 | regulation of cartilage development | 30 | 50 | 1.28e-02 |
| GO:BP | GO:0051148 | negative regulation of muscle cell differentiation | 30 | 50 | 1.28e-02 |
| GO:BP | GO:0055123 | digestive system development | 51 | 96 | 1.28e-02 |
| GO:BP | GO:0030178 | negative regulation of Wnt signaling pathway | 68 | 135 | 1.28e-02 |
| GO:BP | GO:0003018 | vascular process in circulatory system | 93 | 194 | 1.29e-02 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | 654 | 1635 | 1.29e-02 |
| GO:BP | GO:0022409 | positive regulation of cell-cell adhesion | 85 | 175 | 1.29e-02 |
| GO:BP | GO:0003148 | outflow tract septum morphogenesis | 16 | 22 | 1.29e-02 |
| GO:BP | GO:0012501 | programmed cell death | 572 | 1419 | 1.30e-02 |
| GO:BP | GO:0048639 | positive regulation of developmental growth | 61 | 119 | 1.34e-02 |
| GO:BP | GO:0032231 | regulation of actin filament bundle assembly | 46 | 85 | 1.35e-02 |
| GO:BP | GO:0086001 | cardiac muscle cell action potential | 36 | 63 | 1.35e-02 |
| GO:BP | GO:0045446 | endothelial cell differentiation | 46 | 85 | 1.35e-02 |
| GO:BP | GO:0021761 | limbic system development | 46 | 85 | 1.35e-02 |
| GO:BP | GO:0097061 | dendritic spine organization | 36 | 63 | 1.35e-02 |
| GO:BP | GO:0035019 | somatic stem cell population maintenance | 28 | 46 | 1.36e-02 |
| GO:BP | GO:0003407 | neural retina development | 28 | 46 | 1.36e-02 |
| GO:BP | GO:0050954 | sensory perception of mechanical stimulus | 57 | 110 | 1.38e-02 |
| GO:BP | GO:0030516 | regulation of axon extension | 41 | 74 | 1.38e-02 |
| GO:BP | GO:0031644 | regulation of nervous system process | 41 | 74 | 1.38e-02 |
| GO:BP | GO:0017145 | stem cell division | 17 | 24 | 1.38e-02 |
| GO:BP | GO:0086002 | cardiac muscle cell action potential involved in contraction | 27 | 44 | 1.40e-02 |
| GO:BP | GO:0061614 | miRNA transcription | 35 | 61 | 1.42e-02 |
| GO:BP | GO:0060491 | regulation of cell projection assembly | 78 | 159 | 1.43e-02 |
| GO:BP | GO:0042391 | regulation of membrane potential | 129 | 282 | 1.44e-02 |
| GO:BP | GO:0007623 | circadian rhythm | 75 | 152 | 1.44e-02 |
| GO:BP | GO:0086009 | membrane repolarization | 26 | 42 | 1.44e-02 |
| GO:BP | GO:0051336 | regulation of hydrolase activity | 189 | 431 | 1.44e-02 |
| GO:BP | GO:0045058 | T cell selection | 18 | 26 | 1.45e-02 |
| GO:BP | GO:0031327 | negative regulation of cellular biosynthetic process | 649 | 1624 | 1.45e-02 |
| GO:BP | GO:0060317 | cardiac epithelial to mesenchymal transition | 19 | 28 | 1.51e-02 |
| GO:BP | GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 77 | 157 | 1.53e-02 |
| GO:BP | GO:0001759 | organ induction | 12 | 15 | 1.53e-02 |
| GO:BP | GO:0038179 | neurotrophin signaling pathway | 23 | 36 | 1.53e-02 |
| GO:BP | GO:0043369 | CD4-positive or CD8-positive, alpha-beta T cell lineage commitment | 12 | 15 | 1.53e-02 |
| GO:BP | GO:0001937 | negative regulation of endothelial cell proliferation | 20 | 30 | 1.53e-02 |
| GO:BP | GO:0032330 | regulation of chondrocyte differentiation | 22 | 34 | 1.54e-02 |
| GO:BP | GO:0042325 | regulation of phosphorylation | 288 | 683 | 1.55e-02 |
| GO:BP | GO:0010976 | positive regulation of neuron projection development | 65 | 129 | 1.55e-02 |
| GO:BP | GO:0018209 | peptidyl-serine modification | 82 | 169 | 1.57e-02 |
| GO:BP | GO:0046834 | lipid phosphorylation | 9 | 10 | 1.59e-02 |
| GO:BP | GO:0060572 | morphogenesis of an epithelial bud | 9 | 10 | 1.59e-02 |
| GO:BP | GO:0061458 | reproductive system development | 97 | 205 | 1.61e-02 |
| GO:BP | GO:0048754 | branching morphogenesis of an epithelial tube | 58 | 113 | 1.62e-02 |
| GO:BP | GO:0055085 | transmembrane transport | 380 | 921 | 1.64e-02 |
| GO:BP | GO:0061387 | regulation of extent of cell growth | 47 | 88 | 1.64e-02 |
| GO:BP | GO:0010959 | regulation of metal ion transport | 111 | 239 | 1.64e-02 |
| GO:BP | GO:0007254 | JNK cascade | 64 | 127 | 1.67e-02 |
| GO:BP | GO:0044089 | positive regulation of cellular component biogenesis | 172 | 390 | 1.73e-02 |
| GO:BP | GO:0051492 | regulation of stress fiber assembly | 42 | 77 | 1.74e-02 |
| GO:BP | GO:0048332 | mesoderm morphogenesis | 31 | 53 | 1.74e-02 |
| GO:BP | GO:0045639 | positive regulation of myeloid cell differentiation | 37 | 66 | 1.75e-02 |
| GO:BP | GO:0051153 | regulation of striated muscle cell differentiation | 37 | 66 | 1.75e-02 |
| GO:BP | GO:0001558 | regulation of cell growth | 145 | 323 | 1.77e-02 |
| GO:BP | GO:0043067 | regulation of programmed cell death | 433 | 1060 | 1.79e-02 |
| GO:BP | GO:0042060 | wound healing | 132 | 291 | 1.79e-02 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | 634 | 1588 | 1.79e-02 |
| GO:BP | GO:0010977 | negative regulation of neuron projection development | 56 | 109 | 1.88e-02 |
| GO:BP | GO:0045765 | regulation of angiogenesis | 92 | 194 | 1.92e-02 |
| GO:BP | GO:0051641 | cellular localization | 1022 | 2623 | 1.95e-02 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | 271 | 642 | 1.96e-02 |
| GO:BP | GO:0003158 | endothelium development | 52 | 100 | 1.96e-02 |
| GO:BP | GO:0043149 | stress fiber assembly | 48 | 91 | 2.01e-02 |
| GO:BP | GO:0030038 | contractile actin filament bundle assembly | 48 | 91 | 2.01e-02 |
| GO:BP | GO:0045600 | positive regulation of fat cell differentiation | 28 | 47 | 2.02e-02 |
| GO:BP | GO:0030048 | actin filament-based movement | 55 | 107 | 2.02e-02 |
| GO:BP | GO:0090066 | regulation of anatomical structure size | 167 | 379 | 2.08e-02 |
| GO:BP | GO:0002360 | T cell lineage commitment | 14 | 19 | 2.09e-02 |
| GO:BP | GO:0021772 | olfactory bulb development | 14 | 19 | 2.09e-02 |
| GO:BP | GO:0060997 | dendritic spine morphogenesis | 27 | 45 | 2.09e-02 |
| GO:BP | GO:0060512 | prostate gland morphogenesis | 14 | 19 | 2.09e-02 |
| GO:BP | GO:2000647 | negative regulation of stem cell proliferation | 14 | 19 | 2.09e-02 |
| GO:BP | GO:0048566 | embryonic digestive tract development | 14 | 19 | 2.09e-02 |
| GO:BP | GO:0060740 | prostate gland epithelium morphogenesis | 14 | 19 | 2.09e-02 |
| GO:BP | GO:0106027 | neuron projection organization | 39 | 71 | 2.10e-02 |
| GO:BP | GO:0042981 | regulation of apoptotic process | 421 | 1031 | 2.10e-02 |
| GO:BP | GO:0007162 | negative regulation of cell adhesion | 88 | 185 | 2.11e-02 |
| GO:BP | GO:0048608 | reproductive structure development | 95 | 202 | 2.18e-02 |
| GO:BP | GO:0048844 | artery morphogenesis | 33 | 58 | 2.22e-02 |
| GO:BP | GO:0072028 | nephron morphogenesis | 33 | 58 | 2.22e-02 |
| GO:BP | GO:0016192 | vesicle-mediated transport | 467 | 1152 | 2.22e-02 |
| GO:BP | GO:0007605 | sensory perception of sound | 50 | 96 | 2.24e-02 |
| GO:BP | GO:0061383 | trabecula morphogenesis | 25 | 41 | 2.26e-02 |
| GO:BP | GO:0086011 | membrane repolarization during action potential | 15 | 21 | 2.27e-02 |
| GO:BP | GO:0021983 | pituitary gland development | 15 | 21 | 2.27e-02 |
| GO:BP | GO:0070252 | actin-mediated cell contraction | 46 | 87 | 2.29e-02 |
| GO:BP | GO:0050773 | regulation of dendrite development | 42 | 78 | 2.30e-02 |
| GO:BP | GO:0001763 | morphogenesis of a branching structure | 71 | 145 | 2.31e-02 |
| GO:BP | GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation | 10 | 12 | 2.31e-02 |
| GO:BP | GO:0045176 | apical protein localization | 10 | 12 | 2.31e-02 |
| GO:BP | GO:0002088 | lens development in camera-type eye | 32 | 56 | 2.31e-02 |
| GO:BP | GO:0045670 | regulation of osteoclast differentiation | 24 | 39 | 2.31e-02 |
| GO:BP | GO:0032486 | Rap protein signal transduction | 10 | 12 | 2.31e-02 |
| GO:BP | GO:0014009 | glial cell proliferation | 24 | 39 | 2.31e-02 |
| GO:BP | GO:0048708 | astrocyte differentiation | 32 | 56 | 2.31e-02 |
| GO:BP | GO:0001658 | branching involved in ureteric bud morphogenesis | 24 | 39 | 2.31e-02 |
| GO:BP | GO:0051491 | positive regulation of filopodium assembly | 16 | 23 | 2.38e-02 |
| GO:BP | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 16 | 23 | 2.38e-02 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 604 | 1514 | 2.42e-02 |
| GO:BP | GO:0051963 | regulation of synapse assembly | 41 | 76 | 2.43e-02 |
| GO:BP | GO:0048640 | negative regulation of developmental growth | 45 | 85 | 2.43e-02 |
| GO:BP | GO:0001775 | cell activation | 264 | 627 | 2.51e-02 |
| GO:BP | GO:0030857 | negative regulation of epithelial cell differentiation | 20 | 31 | 2.53e-02 |
| GO:BP | GO:0099622 | cardiac muscle cell membrane repolarization | 20 | 31 | 2.53e-02 |
| GO:BP | GO:0060563 | neuroepithelial cell differentiation | 19 | 29 | 2.53e-02 |
| GO:BP | GO:0006810 | transport | 1154 | 2984 | 2.53e-02 |
| GO:BP | GO:0051050 | positive regulation of transport | 242 | 571 | 2.57e-02 |
| GO:BP | GO:0061180 | mammary gland epithelium development | 30 | 52 | 2.59e-02 |
| GO:BP | GO:0001708 | cell fate specification | 30 | 52 | 2.59e-02 |
| GO:BP | GO:0045927 | positive regulation of growth | 87 | 184 | 2.67e-02 |
| GO:BP | GO:0007043 | cell-cell junction assembly | 54 | 106 | 2.70e-02 |
| GO:BP | GO:0002011 | morphogenesis of an epithelial sheet | 29 | 50 | 2.74e-02 |
| GO:BP | GO:0042490 | mechanoreceptor differentiation | 29 | 50 | 2.74e-02 |
| GO:BP | GO:0030199 | collagen fibril organization | 29 | 50 | 2.74e-02 |
| GO:BP | GO:0006936 | muscle contraction | 116 | 255 | 2.85e-02 |
| GO:BP | GO:0035249 | synaptic transmission, glutamatergic | 34 | 61 | 2.87e-02 |
| GO:BP | GO:0008306 | associative learning | 34 | 61 | 2.87e-02 |
| GO:BP | GO:0001656 | metanephros development | 34 | 61 | 2.87e-02 |
| GO:BP | GO:0060113 | inner ear receptor cell differentiation | 28 | 48 | 2.90e-02 |
| GO:BP | GO:0071772 | response to BMP | 59 | 118 | 2.94e-02 |
| GO:BP | GO:0071773 | cellular response to BMP stimulus | 59 | 118 | 2.94e-02 |
| GO:BP | GO:0048485 | sympathetic nervous system development | 11 | 14 | 2.94e-02 |
| GO:BP | GO:0010842 | retina layer formation | 11 | 14 | 2.94e-02 |
| GO:BP | GO:0002363 | alpha-beta T cell lineage commitment | 11 | 14 | 2.94e-02 |
| GO:BP | GO:0008347 | glial cell migration | 27 | 46 | 3.05e-02 |
| GO:BP | GO:0072171 | mesonephric tubule morphogenesis | 27 | 46 | 3.05e-02 |
| GO:BP | GO:0035725 | sodium ion transmembrane transport | 49 | 95 | 3.05e-02 |
| GO:BP | GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction | 99 | 214 | 3.11e-02 |
| GO:BP | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 55 | 109 | 3.16e-02 |
| GO:BP | GO:0098657 | import into cell | 261 | 622 | 3.19e-02 |
| GO:BP | GO:0060324 | face development | 26 | 44 | 3.20e-02 |
| GO:BP | GO:0002042 | cell migration involved in sprouting angiogenesis | 26 | 44 | 3.20e-02 |
| GO:BP | GO:0014033 | neural crest cell differentiation | 41 | 77 | 3.22e-02 |
| GO:BP | GO:0007600 | sensory perception | 114 | 251 | 3.23e-02 |
| GO:BP | GO:0021954 | central nervous system neuron development | 32 | 57 | 3.24e-02 |
| GO:BP | GO:0001954 | positive regulation of cell-matrix adhesion | 25 | 42 | 3.36e-02 |
| GO:BP | GO:0060601 | lateral sprouting from an epithelium | 8 | 9 | 3.36e-02 |
| GO:BP | GO:1901329 | regulation of odontoblast differentiation | 8 | 9 | 3.36e-02 |
| GO:BP | GO:0045986 | negative regulation of smooth muscle contraction | 8 | 9 | 3.36e-02 |
| GO:BP | GO:0008361 | regulation of cell size | 71 | 147 | 3.37e-02 |
| GO:BP | GO:0006935 | chemotaxis | 111 | 244 | 3.39e-02 |
| GO:BP | GO:0007498 | mesoderm development | 44 | 84 | 3.39e-02 |
| GO:BP | GO:0042330 | taxis | 111 | 244 | 3.39e-02 |
| GO:BP | GO:0055008 | cardiac muscle tissue morphogenesis | 31 | 55 | 3.44e-02 |
| GO:BP | GO:0045668 | negative regulation of osteoblast differentiation | 23 | 38 | 3.68e-02 |
| GO:BP | GO:0061001 | regulation of dendritic spine morphogenesis | 22 | 36 | 3.84e-02 |
| GO:BP | GO:0003203 | endocardial cushion morphogenesis | 22 | 36 | 3.84e-02 |
| GO:BP | GO:0048704 | embryonic skeletal system morphogenesis | 29 | 51 | 3.94e-02 |
| GO:BP | GO:0001707 | mesoderm formation | 29 | 51 | 3.94e-02 |
| GO:BP | GO:0051591 | response to cAMP | 34 | 62 | 3.95e-02 |
| GO:BP | GO:0050865 | regulation of cell activation | 152 | 347 | 3.96e-02 |
| GO:BP | GO:0030509 | BMP signaling pathway | 55 | 110 | 3.96e-02 |
| GO:BP | GO:0007159 | leukocyte cell-cell adhesion | 100 | 218 | 3.96e-02 |
| GO:BP | GO:0010629 | negative regulation of gene expression | 325 | 790 | 4.01e-02 |
| GO:BP | GO:0045926 | negative regulation of growth | 86 | 184 | 4.02e-02 |
| GO:BP | GO:0002053 | positive regulation of mesenchymal cell proliferation | 14 | 20 | 4.04e-02 |
| GO:BP | GO:0021516 | dorsal spinal cord development | 6 | 6 | 4.04e-02 |
| GO:BP | GO:0048617 | embryonic foregut morphogenesis | 6 | 6 | 4.04e-02 |
| GO:BP | GO:1901289 | succinyl-CoA catabolic process | 6 | 6 | 4.04e-02 |
| GO:BP | GO:0072178 | nephric duct morphogenesis | 6 | 6 | 4.04e-02 |
| GO:BP | GO:0050861 | positive regulation of B cell receptor signaling pathway | 6 | 6 | 4.04e-02 |
| GO:BP | GO:0021814 | cell motility involved in cerebral cortex radial glia guided migration | 6 | 6 | 4.04e-02 |
| GO:BP | GO:0050982 | detection of mechanical stimulus | 20 | 32 | 4.05e-02 |
| GO:BP | GO:0008154 | actin polymerization or depolymerization | 71 | 148 | 4.05e-02 |
| GO:BP | GO:0032233 | positive regulation of actin filament bundle assembly | 28 | 49 | 4.13e-02 |
| GO:BP | GO:0060914 | heart formation | 19 | 30 | 4.15e-02 |
| GO:BP | GO:0033688 | regulation of osteoblast proliferation | 15 | 22 | 4.16e-02 |
| GO:BP | GO:0048661 | positive regulation of smooth muscle cell proliferation | 33 | 60 | 4.16e-02 |
| GO:BP | GO:0021675 | nerve development | 33 | 60 | 4.16e-02 |
| GO:BP | GO:1902107 | positive regulation of leukocyte differentiation | 57 | 115 | 4.17e-02 |
| GO:BP | GO:1903708 | positive regulation of hemopoiesis | 57 | 115 | 4.17e-02 |
| GO:BP | GO:0072006 | nephron development | 57 | 115 | 4.17e-02 |
| GO:BP | GO:0030510 | regulation of BMP signaling pathway | 41 | 78 | 4.17e-02 |
| GO:BP | GO:0021799 | cerebral cortex radially oriented cell migration | 17 | 26 | 4.18e-02 |
| GO:BP | GO:0071392 | cellular response to estradiol stimulus | 16 | 24 | 4.18e-02 |
| GO:BP | GO:0048048 | embryonic eye morphogenesis | 16 | 24 | 4.18e-02 |
| GO:BP | GO:0003181 | atrioventricular valve morphogenesis | 17 | 26 | 4.18e-02 |
| GO:BP | GO:0040036 | regulation of fibroblast growth factor receptor signaling pathway | 16 | 24 | 4.18e-02 |
| GO:BP | GO:0086064 | cell communication by electrical coupling involved in cardiac conduction | 17 | 26 | 4.18e-02 |
| GO:BP | GO:0110110 | positive regulation of animal organ morphogenesis | 17 | 26 | 4.18e-02 |
| GO:BP | GO:0035282 | segmentation | 37 | 69 | 4.18e-02 |
| GO:BP | GO:0033687 | osteoblast proliferation | 17 | 26 | 4.18e-02 |
| GO:BP | GO:0010721 | negative regulation of cell development | 85 | 182 | 4.19e-02 |
| GO:BP | GO:0033135 | regulation of peptidyl-serine phosphorylation | 44 | 85 | 4.30e-02 |
| GO:BP | GO:0050790 | regulation of catalytic activity | 364 | 893 | 4.37e-02 |
| GO:BP | GO:0061333 | renal tubule morphogenesis | 32 | 58 | 4.38e-02 |
| GO:BP | GO:0008543 | fibroblast growth factor receptor signaling pathway | 32 | 58 | 4.38e-02 |
| GO:BP | GO:0071805 | potassium ion transmembrane transport | 59 | 120 | 4.38e-02 |
| GO:BP | GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 56 | 113 | 4.43e-02 |
| GO:BP | GO:0055001 | muscle cell development | 77 | 163 | 4.43e-02 |
| GO:BP | GO:0060675 | ureteric bud morphogenesis | 26 | 45 | 4.56e-02 |
| GO:BP | GO:0035331 | negative regulation of hippo signaling | 9 | 11 | 4.61e-02 |
| GO:BP | GO:0021895 | cerebral cortex neuron differentiation | 9 | 11 | 4.61e-02 |
| GO:BP | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 43 | 83 | 4.62e-02 |
| GO:BP | GO:0072088 | nephron epithelium morphogenesis | 31 | 56 | 4.67e-02 |
| GO:BP | GO:0003229 | ventricular cardiac muscle tissue development | 31 | 56 | 4.67e-02 |
| GO:BP | GO:0046928 | regulation of neurotransmitter secretion | 31 | 56 | 4.67e-02 |
| GO:BP | GO:0002682 | regulation of immune system process | 354 | 868 | 4.70e-02 |
| GO:BP | GO:0110053 | regulation of actin filament organization | 97 | 212 | 4.70e-02 |
| GO:BP | GO:0061326 | renal tubule development | 39 | 74 | 4.75e-02 |
| GO:BP | GO:0048864 | stem cell development | 39 | 74 | 4.75e-02 |
| GO:BP | GO:0030316 | osteoclast differentiation | 35 | 65 | 4.78e-02 |
| GO:BP | GO:0051496 | positive regulation of stress fiber assembly | 25 | 43 | 4.78e-02 |
| GO:BP | GO:0009880 | embryonic pattern specification | 25 | 43 | 4.78e-02 |
| GO:BP | GO:0050679 | positive regulation of epithelial cell proliferation | 68 | 142 | 4.93e-02 |
| GO:BP | GO:0019722 | calcium-mediated signaling | 60 | 123 | 4.97e-02 |
| GO:BP | GO:0072078 | nephron tubule morphogenesis | 30 | 54 | 4.97e-02 |
EARnomtable %>%
filter(source=="KEGG", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in EAR neargenes") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:04510 | Focal adhesion | 97 | 169 | 6.03e-06 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | 90 | 162 | 7.47e-05 |
| KEGG | KEGG:04360 | Axon guidance | 84 | 155 | 4.62e-04 |
| KEGG | KEGG:04512 | ECM-receptor interaction | 42 | 66 | 5.12e-04 |
| KEGG | KEGG:04520 | Adherens junction | 49 | 83 | 1.45e-03 |
| KEGG | KEGG:04310 | Wnt signaling pathway | 71 | 133 | 2.44e-03 |
| KEGG | KEGG:04024 | cAMP signaling pathway | 75 | 147 | 6.33e-03 |
| KEGG | KEGG:04010 | MAPK signaling pathway | 111 | 231 | 6.33e-03 |
| KEGG | KEGG:04726 | Serotonergic synapse | 35 | 58 | 6.33e-03 |
| KEGG | KEGG:05200 | Pathways in cancer | 177 | 391 | 6.33e-03 |
| KEGG | KEGG:05222 | Small cell lung cancer | 46 | 82 | 6.46e-03 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | 118 | 250 | 7.19e-03 |
| KEGG | KEGG:04014 | Ras signaling pathway | 81 | 164 | 9.91e-03 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | 63 | 122 | 9.91e-03 |
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | 38 | 67 | 1.24e-02 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | 48 | 90 | 1.47e-02 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | 82 | 169 | 1.47e-02 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 79 | 162 | 1.47e-02 |
| KEGG | KEGG:04514 | Cell adhesion molecules | 38 | 69 | 2.10e-02 |
| KEGG | KEGG:04730 | Long-term depression | 24 | 39 | 2.10e-02 |
| KEGG | KEGG:04390 | Hippo signaling pathway | 64 | 129 | 2.22e-02 |
| KEGG | KEGG:04713 | Circadian entrainment | 37 | 68 | 2.80e-02 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 41 | 78 | 3.73e-02 |
| KEGG | KEGG:04068 | FoxO signaling pathway | 53 | 106 | 3.91e-02 |
| KEGG | KEGG:04974 | Protein digestion and absorption | 31 | 56 | 3.97e-02 |
| KEGG | KEGG:04072 | Phospholipase D signaling pathway | 53 | 107 | 4.66e-02 |
EARnomtable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
slice_head(n=10) %>%
mutate(log10_p=(-log(p_value, base=10))) %>%
ggplot(., aes(x=log10_p, y=reorder(term_name, log10_p)))+
geom_col(aes(fill="#F8766D"))+
theme_bw()+
ylab("")+
xlab(paste0("-log10 p-value"))+
guides(fill="none")
ESR response genes
# ESR_resgenes <- gost(query = ESR_NG_list$ENTREZID,
# organism = "hsapiens",
# significant = FALSE,
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = background_df$ENTREZID,
# sources=c("GO:BP","KEGG"))
# saveRDS(ESR_resgenes,"data/GO_KEGG_analysis/ESR_resgenes.RDS")
# ESRnom <- gostplot(ESR_resgenes, capped = FALSE, interactive = TRUE)
# ESRnom
ESRnomtable <- ESR_resgenes$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
ESRnomtable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in ESR neargenes" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0032501 | multicellular organismal process | 2719 | 4504 | 6.19e-51 |
| GO:BP | GO:0048856 | anatomical structure development | 2368 | 3867 | 1.05e-48 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 1237 | 1844 | 1.90e-47 |
| GO:BP | GO:0032502 | developmental process | 2521 | 4179 | 2.35e-45 |
| GO:BP | GO:0007275 | multicellular organism development | 1971 | 3170 | 2.02e-44 |
| GO:BP | GO:0007154 | cell communication | 2411 | 3983 | 2.68e-44 |
| GO:BP | GO:0023052 | signaling | 2374 | 3918 | 7.47e-44 |
| GO:BP | GO:0048731 | system development | 1713 | 2719 | 3.79e-42 |
| GO:BP | GO:0007165 | signal transduction | 2187 | 3611 | 9.13e-39 |
| GO:BP | GO:0030154 | cell differentiation | 1746 | 2803 | 1.06e-38 |
| GO:BP | GO:0048869 | cellular developmental process | 1746 | 2804 | 1.33e-38 |
| GO:BP | GO:0050896 | response to stimulus | 3104 | 5379 | 5.22e-35 |
| GO:BP | GO:0051716 | cellular response to stimulus | 2717 | 4640 | 6.46e-35 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 1237 | 1924 | 5.46e-34 |
| GO:BP | GO:0009888 | tissue development | 904 | 1348 | 2.90e-33 |
| GO:BP | GO:0048513 | animal organ development | 1279 | 2004 | 3.55e-33 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | 597 | 837 | 4.28e-32 |
| GO:BP | GO:0007399 | nervous system development | 1136 | 1775 | 1.60e-29 |
| GO:BP | GO:0007155 | cell adhesion | 651 | 941 | 7.22e-29 |
| GO:BP | GO:0010646 | regulation of cell communication | 1503 | 2444 | 4.76e-28 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | 1142 | 1801 | 2.61e-27 |
| GO:BP | GO:0023051 | regulation of signaling | 1496 | 2438 | 3.01e-27 |
| GO:BP | GO:0035295 | tube development | 553 | 787 | 7.25e-27 |
| GO:BP | GO:0072359 | circulatory system development | 599 | 864 | 8.41e-27 |
| GO:BP | GO:0016477 | cell migration | 686 | 1011 | 9.57e-27 |
| GO:BP | GO:0048468 | cell development | 1184 | 1886 | 5.73e-26 |
| GO:BP | GO:0050793 | regulation of developmental process | 1076 | 1697 | 1.61e-25 |
| GO:BP | GO:0048870 | cell motility | 745 | 1120 | 2.94e-25 |
| GO:BP | GO:0035239 | tube morphogenesis | 458 | 638 | 3.31e-25 |
| GO:BP | GO:0022008 | neurogenesis | 819 | 1251 | 9.61e-25 |
| GO:BP | GO:0003008 | system process | 752 | 1139 | 4.38e-24 |
| GO:BP | GO:0048729 | tissue morphogenesis | 340 | 453 | 6.87e-24 |
| GO:BP | GO:0009887 | animal organ morphogenesis | 475 | 673 | 1.46e-23 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | 692 | 1040 | 2.24e-23 |
| GO:BP | GO:0048699 | generation of neurons | 711 | 1076 | 8.28e-23 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | 637 | 951 | 1.83e-22 |
| GO:BP | GO:0030182 | neuron differentiation | 671 | 1014 | 1.21e-21 |
| GO:BP | GO:0141124 | intracellular signaling cassette | 842 | 1314 | 2.89e-21 |
| GO:BP | GO:0007267 | cell-cell signaling | 709 | 1082 | 2.91e-21 |
| GO:BP | GO:0009966 | regulation of signal transduction | 1316 | 2166 | 6.52e-21 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | 493 | 717 | 1.33e-20 |
| GO:BP | GO:0051094 | positive regulation of developmental process | 607 | 913 | 3.88e-20 |
| GO:BP | GO:0030334 | regulation of cell migration | 461 | 668 | 1.15e-19 |
| GO:BP | GO:0001944 | vasculature development | 391 | 552 | 1.24e-19 |
| GO:BP | GO:0050789 | regulation of biological process | 4101 | 7516 | 3.07e-19 |
| GO:BP | GO:0040011 | locomotion | 540 | 805 | 5.25e-19 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 1605 | 2717 | 7.46e-19 |
| GO:BP | GO:2000145 | regulation of cell motility | 477 | 700 | 1.07e-18 |
| GO:BP | GO:0001568 | blood vessel development | 372 | 525 | 1.07e-18 |
| GO:BP | GO:0044057 | regulation of system process | 285 | 384 | 1.07e-18 |
| GO:BP | GO:0065007 | biological regulation | 4205 | 7734 | 1.75e-18 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | 422 | 609 | 1.86e-18 |
| GO:BP | GO:0040012 | regulation of locomotion | 488 | 720 | 1.89e-18 |
| GO:BP | GO:0060429 | epithelium development | 530 | 792 | 2.43e-18 |
| GO:BP | GO:0034330 | cell junction organization | 383 | 545 | 2.60e-18 |
| GO:BP | GO:0098609 | cell-cell adhesion | 394 | 564 | 3.80e-18 |
| GO:BP | GO:0050794 | regulation of cellular process | 3906 | 7153 | 1.53e-17 |
| GO:BP | GO:0048514 | blood vessel morphogenesis | 323 | 450 | 1.64e-17 |
| GO:BP | GO:0030029 | actin filament-based process | 437 | 640 | 2.59e-17 |
| GO:BP | GO:0002009 | morphogenesis of an epithelium | 272 | 369 | 3.69e-17 |
| GO:BP | GO:0000902 | cell morphogenesis | 478 | 713 | 1.18e-16 |
| GO:BP | GO:0009790 | embryo development | 541 | 821 | 1.22e-16 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 664 | 1035 | 1.36e-16 |
| GO:BP | GO:0035556 | intracellular signal transduction | 1175 | 1951 | 1.58e-16 |
| GO:BP | GO:0045595 | regulation of cell differentiation | 685 | 1073 | 1.95e-16 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | 405 | 591 | 2.08e-16 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | 403 | 588 | 2.42e-16 |
| GO:BP | GO:0003013 | circulatory system process | 305 | 426 | 2.87e-16 |
| GO:BP | GO:0048518 | positive regulation of biological process | 2429 | 4301 | 3.13e-16 |
| GO:BP | GO:0060485 | mesenchyme development | 191 | 245 | 3.48e-16 |
| GO:BP | GO:0048519 | negative regulation of biological process | 2146 | 3764 | 3.74e-16 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 2246 | 3954 | 3.89e-16 |
| GO:BP | GO:0048598 | embryonic morphogenesis | 302 | 422 | 4.42e-16 |
| GO:BP | GO:0030155 | regulation of cell adhesion | 354 | 508 | 5.26e-16 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 2030 | 3550 | 9.49e-16 |
| GO:BP | GO:0070848 | response to growth factor | 376 | 547 | 1.55e-15 |
| GO:BP | GO:0007507 | heart development | 347 | 499 | 1.86e-15 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 1120 | 1862 | 1.96e-15 |
| GO:BP | GO:0008015 | blood circulation | 260 | 357 | 2.56e-15 |
| GO:BP | GO:0065008 | regulation of biological quality | 1136 | 1893 | 2.94e-15 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 749 | 1197 | 4.69e-15 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | 722 | 1150 | 6.09e-15 |
| GO:BP | GO:0048666 | neuron development | 544 | 838 | 7.15e-15 |
| GO:BP | GO:0061061 | muscle structure development | 367 | 536 | 9.31e-15 |
| GO:BP | GO:0030030 | cell projection organization | 739 | 1182 | 1.01e-14 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | 362 | 528 | 1.09e-14 |
| GO:BP | GO:0031175 | neuron projection development | 488 | 743 | 1.35e-14 |
| GO:BP | GO:0014706 | striated muscle tissue development | 167 | 213 | 1.47e-14 |
| GO:BP | GO:0048762 | mesenchymal cell differentiation | 158 | 200 | 2.74e-14 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | 158 | 201 | 6.30e-14 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | 382 | 566 | 6.89e-14 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | 676 | 1077 | 6.96e-14 |
| GO:BP | GO:0001525 | angiogenesis | 271 | 381 | 7.21e-14 |
| GO:BP | GO:0120039 | plasma membrane bounded cell projection morphogenesis | 338 | 494 | 1.76e-13 |
| GO:BP | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 315 | 456 | 2.20e-13 |
| GO:BP | GO:0048858 | cell projection morphogenesis | 340 | 498 | 2.30e-13 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | 322 | 469 | 3.95e-13 |
| GO:BP | GO:0051241 | negative regulation of multicellular organismal process | 460 | 706 | 7.81e-13 |
| GO:BP | GO:0060562 | epithelial tube morphogenesis | 194 | 261 | 9.34e-13 |
| GO:BP | GO:0010647 | positive regulation of cell communication | 749 | 1218 | 1.35e-12 |
| GO:BP | GO:0023057 | negative regulation of signaling | 647 | 1036 | 1.35e-12 |
| GO:BP | GO:0007423 | sensory organ development | 271 | 387 | 1.52e-12 |
| GO:BP | GO:0023056 | positive regulation of signaling | 750 | 1221 | 1.80e-12 |
| GO:BP | GO:0007010 | cytoskeleton organization | 708 | 1146 | 1.89e-12 |
| GO:BP | GO:0051049 | regulation of transport | 681 | 1098 | 1.98e-12 |
| GO:BP | GO:0008283 | cell population proliferation | 797 | 1306 | 1.99e-12 |
| GO:BP | GO:0010648 | negative regulation of cell communication | 645 | 1034 | 2.00e-12 |
| GO:BP | GO:0048812 | neuron projection morphogenesis | 325 | 479 | 3.29e-12 |
| GO:BP | GO:0003012 | muscle system process | 232 | 325 | 4.33e-12 |
| GO:BP | GO:0060537 | muscle tissue development | 240 | 339 | 6.98e-12 |
| GO:BP | GO:0001667 | ameboidal-type cell migration | 243 | 344 | 7.18e-12 |
| GO:BP | GO:0051093 | negative regulation of developmental process | 407 | 622 | 1.06e-11 |
| GO:BP | GO:0042221 | response to chemical | 1336 | 2304 | 1.47e-11 |
| GO:BP | GO:0006468 | protein phosphorylation | 598 | 958 | 1.59e-11 |
| GO:BP | GO:0034329 | cell junction assembly | 229 | 323 | 1.99e-11 |
| GO:BP | GO:0048667 | cell morphogenesis involved in neuron differentiation | 296 | 435 | 2.60e-11 |
| GO:BP | GO:0120035 | regulation of plasma membrane bounded cell projection organization | 337 | 505 | 3.26e-11 |
| GO:BP | GO:0098657 | import into cell | 405 | 622 | 3.52e-11 |
| GO:BP | GO:0007417 | central nervous system development | 446 | 694 | 4.58e-11 |
| GO:BP | GO:0048589 | developmental growth | 334 | 501 | 4.96e-11 |
| GO:BP | GO:0072001 | renal system development | 179 | 244 | 6.49e-11 |
| GO:BP | GO:0010720 | positive regulation of cell development | 219 | 309 | 6.74e-11 |
| GO:BP | GO:0031344 | regulation of cell projection organization | 342 | 516 | 8.22e-11 |
| GO:BP | GO:0048568 | embryonic organ development | 215 | 303 | 8.93e-11 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | 725 | 1193 | 1.10e-10 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | 777 | 1289 | 1.75e-10 |
| GO:BP | GO:0051960 | regulation of nervous system development | 236 | 339 | 1.76e-10 |
| GO:BP | GO:0060322 | head development | 354 | 539 | 1.98e-10 |
| GO:BP | GO:0072073 | kidney epithelium development | 92 | 111 | 2.23e-10 |
| GO:BP | GO:0030001 | metal ion transport | 345 | 524 | 2.32e-10 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | 600 | 972 | 2.48e-10 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | 667 | 1093 | 3.12e-10 |
| GO:BP | GO:0001501 | skeletal system development | 240 | 347 | 3.22e-10 |
| GO:BP | GO:0003007 | heart morphogenesis | 161 | 218 | 3.42e-10 |
| GO:BP | GO:0003206 | cardiac chamber morphogenesis | 91 | 110 | 3.49e-10 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | 478 | 757 | 3.61e-10 |
| GO:BP | GO:0045165 | cell fate commitment | 118 | 151 | 4.59e-10 |
| GO:BP | GO:0003205 | cardiac chamber development | 118 | 151 | 4.59e-10 |
| GO:BP | GO:0090596 | sensory organ morphogenesis | 132 | 173 | 5.78e-10 |
| GO:BP | GO:0007420 | brain development | 328 | 498 | 7.15e-10 |
| GO:BP | GO:0001822 | kidney development | 172 | 237 | 7.36e-10 |
| GO:BP | GO:0032879 | regulation of localization | 855 | 1439 | 9.26e-10 |
| GO:BP | GO:0034762 | regulation of transmembrane transport | 209 | 298 | 9.79e-10 |
| GO:BP | GO:0007186 | G protein-coupled receptor signaling pathway | 261 | 386 | 1.63e-09 |
| GO:BP | GO:0001823 | mesonephros development | 65 | 74 | 1.79e-09 |
| GO:BP | GO:0006936 | muscle contraction | 182 | 255 | 1.94e-09 |
| GO:BP | GO:1903522 | regulation of blood circulation | 144 | 194 | 2.29e-09 |
| GO:BP | GO:0003231 | cardiac ventricle development | 93 | 115 | 2.36e-09 |
| GO:BP | GO:0010975 | regulation of neuron projection development | 242 | 355 | 2.45e-09 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | 299 | 452 | 2.74e-09 |
| GO:BP | GO:0072164 | mesonephric tubule development | 64 | 73 | 2.95e-09 |
| GO:BP | GO:0072163 | mesonephric epithelium development | 64 | 73 | 2.95e-09 |
| GO:BP | GO:0060284 | regulation of cell development | 367 | 570 | 3.33e-09 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | 177 | 248 | 3.47e-09 |
| GO:BP | GO:0030335 | positive regulation of cell migration | 265 | 395 | 3.86e-09 |
| GO:BP | GO:0016310 | phosphorylation | 689 | 1145 | 4.94e-09 |
| GO:BP | GO:0001657 | ureteric bud development | 63 | 72 | 4.94e-09 |
| GO:BP | GO:0016043 | cellular component organization | 2629 | 4802 | 5.18e-09 |
| GO:BP | GO:0051179 | localization | 2071 | 3731 | 5.58e-09 |
| GO:BP | GO:0030900 | forebrain development | 191 | 272 | 5.75e-09 |
| GO:BP | GO:2000147 | positive regulation of cell motility | 272 | 408 | 5.80e-09 |
| GO:BP | GO:0007264 | small GTPase-mediated signal transduction | 261 | 390 | 7.69e-09 |
| GO:BP | GO:0090257 | regulation of muscle system process | 132 | 177 | 8.05e-09 |
| GO:BP | GO:0045785 | positive regulation of cell adhesion | 208 | 301 | 8.37e-09 |
| GO:BP | GO:0140352 | export from cell | 379 | 594 | 8.42e-09 |
| GO:BP | GO:0060560 | developmental growth involved in morphogenesis | 140 | 190 | 9.34e-09 |
| GO:BP | GO:0003151 | outflow tract morphogenesis | 59 | 67 | 1.06e-08 |
| GO:BP | GO:0060411 | cardiac septum morphogenesis | 59 | 67 | 1.06e-08 |
| GO:BP | GO:0007409 | axonogenesis | 229 | 337 | 1.18e-08 |
| GO:BP | GO:0061448 | connective tissue development | 149 | 205 | 1.27e-08 |
| GO:BP | GO:0043269 | regulation of monoatomic ion transport | 196 | 282 | 1.27e-08 |
| GO:BP | GO:0001837 | epithelial to mesenchymal transition | 106 | 137 | 1.32e-08 |
| GO:BP | GO:0044093 | positive regulation of molecular function | 485 | 783 | 1.39e-08 |
| GO:BP | GO:0060047 | heart contraction | 142 | 194 | 1.46e-08 |
| GO:BP | GO:0051216 | cartilage development | 111 | 145 | 1.55e-08 |
| GO:BP | GO:0040017 | positive regulation of locomotion | 275 | 416 | 1.62e-08 |
| GO:BP | GO:0030855 | epithelial cell differentiation | 282 | 428 | 1.62e-08 |
| GO:BP | GO:0048880 | sensory system development | 186 | 266 | 1.62e-08 |
| GO:BP | GO:0042692 | muscle cell differentiation | 220 | 323 | 1.82e-08 |
| GO:BP | GO:0099177 | regulation of trans-synaptic signaling | 220 | 323 | 1.82e-08 |
| GO:BP | GO:0061564 | axon development | 249 | 372 | 1.82e-08 |
| GO:BP | GO:0001654 | eye development | 184 | 263 | 1.84e-08 |
| GO:BP | GO:0006810 | transport | 1673 | 2984 | 1.89e-08 |
| GO:BP | GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 90 | 113 | 1.89e-08 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | 1015 | 1751 | 2.12e-08 |
| GO:BP | GO:0050808 | synapse organization | 228 | 337 | 2.23e-08 |
| GO:BP | GO:0035265 | organ growth | 99 | 127 | 2.28e-08 |
| GO:BP | GO:0099537 | trans-synaptic signaling | 304 | 467 | 2.31e-08 |
| GO:BP | GO:0050804 | modulation of chemical synaptic transmission | 219 | 322 | 2.36e-08 |
| GO:BP | GO:0009792 | embryo development ending in birth or egg hatching | 335 | 521 | 2.49e-08 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | 1480 | 2622 | 2.65e-08 |
| GO:BP | GO:0002062 | chondrocyte differentiation | 73 | 88 | 2.66e-08 |
| GO:BP | GO:0150063 | visual system development | 184 | 264 | 2.85e-08 |
| GO:BP | GO:0051056 | regulation of small GTPase mediated signal transduction | 165 | 233 | 3.35e-08 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | 301 | 463 | 3.37e-08 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | 301 | 463 | 3.37e-08 |
| GO:BP | GO:0010810 | regulation of cell-substrate adhesion | 121 | 162 | 3.39e-08 |
| GO:BP | GO:0003018 | vascular process in circulatory system | 141 | 194 | 3.39e-08 |
| GO:BP | GO:0065009 | regulation of molecular function | 768 | 1299 | 3.42e-08 |
| GO:BP | GO:0048863 | stem cell differentiation | 139 | 191 | 3.84e-08 |
| GO:BP | GO:0003015 | heart process | 147 | 204 | 3.96e-08 |
| GO:BP | GO:0060419 | heart growth | 61 | 71 | 4.05e-08 |
| GO:BP | GO:0198738 | cell-cell signaling by wnt | 240 | 359 | 4.09e-08 |
| GO:BP | GO:1901888 | regulation of cell junction assembly | 117 | 156 | 4.09e-08 |
| GO:BP | GO:0040007 | growth | 434 | 697 | 4.15e-08 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | 879 | 1504 | 4.15e-08 |
| GO:BP | GO:0050767 | regulation of neurogenesis | 199 | 290 | 4.29e-08 |
| GO:BP | GO:0097485 | neuron projection guidance | 127 | 172 | 4.29e-08 |
| GO:BP | GO:0007411 | axon guidance | 127 | 172 | 4.29e-08 |
| GO:BP | GO:0003279 | cardiac septum development | 82 | 102 | 4.35e-08 |
| GO:BP | GO:0099536 | synaptic signaling | 312 | 483 | 4.35e-08 |
| GO:BP | GO:0090130 | tissue migration | 173 | 247 | 4.71e-08 |
| GO:BP | GO:0043062 | extracellular structure organization | 159 | 224 | 4.73e-08 |
| GO:BP | GO:0045229 | external encapsulating structure organization | 159 | 224 | 4.73e-08 |
| GO:BP | GO:0001775 | cell activation | 394 | 627 | 4.92e-08 |
| GO:BP | GO:0016055 | Wnt signaling pathway | 239 | 358 | 5.11e-08 |
| GO:BP | GO:0010959 | regulation of metal ion transport | 168 | 239 | 5.22e-08 |
| GO:BP | GO:0046903 | secretion | 391 | 622 | 5.28e-08 |
| GO:BP | GO:0007268 | chemical synaptic transmission | 300 | 463 | 5.48e-08 |
| GO:BP | GO:0098916 | anterograde trans-synaptic signaling | 300 | 463 | 5.48e-08 |
| GO:BP | GO:0071310 | cellular response to organic substance | 765 | 1297 | 6.20e-08 |
| GO:BP | GO:0045216 | cell-cell junction organization | 114 | 152 | 6.21e-08 |
| GO:BP | GO:0008284 | positive regulation of cell population proliferation | 381 | 605 | 6.21e-08 |
| GO:BP | GO:0030198 | extracellular matrix organization | 158 | 223 | 6.36e-08 |
| GO:BP | GO:0043009 | chordate embryonic development | 325 | 507 | 6.45e-08 |
| GO:BP | GO:0010243 | response to organonitrogen compound | 426 | 685 | 6.91e-08 |
| GO:BP | GO:0040013 | negative regulation of locomotion | 170 | 243 | 7.05e-08 |
| GO:BP | GO:0090132 | epithelium migration | 170 | 243 | 7.05e-08 |
| GO:BP | GO:0010631 | epithelial cell migration | 170 | 243 | 7.05e-08 |
| GO:BP | GO:0043410 | positive regulation of MAPK cascade | 197 | 288 | 7.18e-08 |
| GO:BP | GO:0031589 | cell-substrate adhesion | 179 | 258 | 7.25e-08 |
| GO:BP | GO:0008016 | regulation of heart contraction | 122 | 165 | 7.25e-08 |
| GO:BP | GO:0006897 | endocytosis | 316 | 492 | 7.78e-08 |
| GO:BP | GO:0072006 | nephron development | 90 | 115 | 8.05e-08 |
| GO:BP | GO:0010033 | response to organic substance | 1002 | 1736 | 8.14e-08 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | 349 | 550 | 8.55e-08 |
| GO:BP | GO:0097435 | supramolecular fiber organization | 396 | 633 | 9.09e-08 |
| GO:BP | GO:0006816 | calcium ion transport | 181 | 262 | 9.74e-08 |
| GO:BP | GO:0051146 | striated muscle cell differentiation | 164 | 234 | 1.07e-07 |
| GO:BP | GO:0006811 | monoatomic ion transport | 444 | 719 | 1.11e-07 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 1364 | 2415 | 1.12e-07 |
| GO:BP | GO:0003208 | cardiac ventricle morphogenesis | 54 | 62 | 1.14e-07 |
| GO:BP | GO:0022407 | regulation of cell-cell adhesion | 190 | 278 | 1.48e-07 |
| GO:BP | GO:0016331 | morphogenesis of embryonic epithelium | 94 | 122 | 1.48e-07 |
| GO:BP | GO:0043010 | camera-type eye development | 161 | 230 | 1.68e-07 |
| GO:BP | GO:0050877 | nervous system process | 376 | 600 | 1.71e-07 |
| GO:BP | GO:0051962 | positive regulation of nervous system development | 150 | 212 | 1.77e-07 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | 516 | 850 | 1.79e-07 |
| GO:BP | GO:0006915 | apoptotic process | 805 | 1377 | 1.93e-07 |
| GO:BP | GO:0060348 | bone development | 109 | 146 | 2.00e-07 |
| GO:BP | GO:0035148 | tube formation | 95 | 124 | 2.01e-07 |
| GO:BP | GO:0010632 | regulation of epithelial cell migration | 135 | 188 | 2.28e-07 |
| GO:BP | GO:0061035 | regulation of cartilage development | 45 | 50 | 2.39e-07 |
| GO:BP | GO:0071417 | cellular response to organonitrogen compound | 285 | 442 | 2.61e-07 |
| GO:BP | GO:0050673 | epithelial cell proliferation | 202 | 300 | 3.06e-07 |
| GO:BP | GO:0032940 | secretion by cell | 347 | 551 | 3.08e-07 |
| GO:BP | GO:0043408 | regulation of MAPK cascade | 276 | 427 | 3.18e-07 |
| GO:BP | GO:1901698 | response to nitrogen compound | 451 | 736 | 3.30e-07 |
| GO:BP | GO:0070588 | calcium ion transmembrane transport | 148 | 210 | 3.30e-07 |
| GO:BP | GO:0051234 | establishment of localization | 1795 | 3240 | 3.40e-07 |
| GO:BP | GO:0008219 | cell death | 828 | 1423 | 3.56e-07 |
| GO:BP | GO:0031399 | regulation of protein modification process | 548 | 911 | 3.60e-07 |
| GO:BP | GO:0034220 | monoatomic ion transmembrane transport | 367 | 587 | 3.67e-07 |
| GO:BP | GO:0033002 | muscle cell proliferation | 112 | 152 | 4.19e-07 |
| GO:BP | GO:0012501 | programmed cell death | 825 | 1419 | 4.62e-07 |
| GO:BP | GO:0023061 | signal release | 210 | 315 | 5.25e-07 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | 647 | 1093 | 5.44e-07 |
| GO:BP | GO:0009605 | response to external stimulus | 900 | 1559 | 5.67e-07 |
| GO:BP | GO:0061138 | morphogenesis of a branching epithelium | 101 | 135 | 5.72e-07 |
| GO:BP | GO:0071773 | cellular response to BMP stimulus | 90 | 118 | 7.05e-07 |
| GO:BP | GO:0071772 | response to BMP | 90 | 118 | 7.05e-07 |
| GO:BP | GO:0034765 | regulation of monoatomic ion transmembrane transport | 147 | 210 | 7.29e-07 |
| GO:BP | GO:0031325 | positive regulation of cellular metabolic process | 1313 | 2333 | 7.32e-07 |
| GO:BP | GO:0001763 | morphogenesis of a branching structure | 107 | 145 | 7.56e-07 |
| GO:BP | GO:0006937 | regulation of muscle contraction | 95 | 126 | 7.75e-07 |
| GO:BP | GO:0098660 | inorganic ion transmembrane transport | 328 | 521 | 7.90e-07 |
| GO:BP | GO:0061326 | renal tubule development | 61 | 74 | 8.38e-07 |
| GO:BP | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 191 | 284 | 8.38e-07 |
| GO:BP | GO:0051046 | regulation of secretion | 256 | 396 | 1.02e-06 |
| GO:BP | GO:0072175 | epithelial tube formation | 89 | 117 | 1.03e-06 |
| GO:BP | GO:0055017 | cardiac muscle tissue growth | 54 | 64 | 1.10e-06 |
| GO:BP | GO:0001503 | ossification | 201 | 302 | 1.24e-06 |
| GO:BP | GO:1901342 | regulation of vasculature development | 139 | 198 | 1.29e-06 |
| GO:BP | GO:0045664 | regulation of neuron differentiation | 97 | 130 | 1.33e-06 |
| GO:BP | GO:0010717 | regulation of epithelial to mesenchymal transition | 68 | 85 | 1.35e-06 |
| GO:BP | GO:0007159 | leukocyte cell-cell adhesion | 151 | 218 | 1.36e-06 |
| GO:BP | GO:0007162 | negative regulation of cell adhesion | 131 | 185 | 1.38e-06 |
| GO:BP | GO:0060038 | cardiac muscle cell proliferation | 39 | 43 | 1.41e-06 |
| GO:BP | GO:0030336 | negative regulation of cell migration | 146 | 210 | 1.55e-06 |
| GO:BP | GO:0007610 | behavior | 269 | 420 | 1.57e-06 |
| GO:BP | GO:0048562 | embryonic organ morphogenesis | 129 | 182 | 1.58e-06 |
| GO:BP | GO:0042472 | inner ear morphogenesis | 51 | 60 | 1.58e-06 |
| GO:BP | GO:0009611 | response to wounding | 247 | 382 | 1.68e-06 |
| GO:BP | GO:0035051 | cardiocyte differentiation | 98 | 132 | 1.68e-06 |
| GO:BP | GO:0007369 | gastrulation | 103 | 140 | 1.69e-06 |
| GO:BP | GO:0007389 | pattern specification process | 191 | 286 | 1.78e-06 |
| GO:BP | GO:2000146 | negative regulation of cell motility | 150 | 217 | 1.79e-06 |
| GO:BP | GO:0050769 | positive regulation of neurogenesis | 130 | 184 | 1.86e-06 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | 480 | 796 | 1.86e-06 |
| GO:BP | GO:0055085 | transmembrane transport | 549 | 921 | 1.86e-06 |
| GO:BP | GO:0030048 | actin filament-based movement | 82 | 107 | 1.90e-06 |
| GO:BP | GO:0006935 | chemotaxis | 166 | 244 | 1.95e-06 |
| GO:BP | GO:0042330 | taxis | 166 | 244 | 1.95e-06 |
| GO:BP | GO:0003281 | ventricular septum development | 57 | 69 | 1.95e-06 |
| GO:BP | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 61 | 75 | 2.05e-06 |
| GO:BP | GO:0030510 | regulation of BMP signaling pathway | 63 | 78 | 2.05e-06 |
| GO:BP | GO:0045321 | leukocyte activation | 331 | 530 | 2.06e-06 |
| GO:BP | GO:0046777 | protein autophosphorylation | 104 | 142 | 2.07e-06 |
| GO:BP | GO:0043085 | positive regulation of catalytic activity | 340 | 546 | 2.08e-06 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | 1069 | 1883 | 2.08e-06 |
| GO:BP | GO:0003229 | ventricular cardiac muscle tissue development | 48 | 56 | 2.17e-06 |
| GO:BP | GO:0007015 | actin filament organization | 232 | 357 | 2.19e-06 |
| GO:BP | GO:0044089 | positive regulation of cellular component biogenesis | 251 | 390 | 2.24e-06 |
| GO:BP | GO:0006812 | monoatomic cation transport | 378 | 614 | 2.31e-06 |
| GO:BP | GO:2000027 | regulation of animal organ morphogenesis | 50 | 59 | 2.45e-06 |
| GO:BP | GO:0150115 | cell-substrate junction organization | 74 | 95 | 2.46e-06 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | 484 | 805 | 2.62e-06 |
| GO:BP | GO:0042327 | positive regulation of phosphorylation | 265 | 415 | 2.69e-06 |
| GO:BP | GO:0098662 | inorganic cation transmembrane transport | 302 | 480 | 2.78e-06 |
| GO:BP | GO:0007517 | muscle organ development | 179 | 267 | 2.87e-06 |
| GO:BP | GO:0048839 | inner ear development | 98 | 133 | 2.92e-06 |
| GO:BP | GO:0060993 | kidney morphogenesis | 56 | 68 | 2.99e-06 |
| GO:BP | GO:0048645 | animal organ formation | 45 | 52 | 2.99e-06 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | 542 | 911 | 3.04e-06 |
| GO:BP | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 145 | 210 | 3.05e-06 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | 483 | 804 | 3.05e-06 |
| GO:BP | GO:0014033 | neural crest cell differentiation | 62 | 77 | 3.06e-06 |
| GO:BP | GO:1902533 | positive regulation of intracellular signal transduction | 433 | 714 | 3.17e-06 |
| GO:BP | GO:0051050 | positive regulation of transport | 353 | 571 | 3.29e-06 |
| GO:BP | GO:0043583 | ear development | 109 | 151 | 3.37e-06 |
| GO:BP | GO:0055008 | cardiac muscle tissue morphogenesis | 47 | 55 | 3.45e-06 |
| GO:BP | GO:0098655 | monoatomic cation transmembrane transport | 310 | 495 | 3.46e-06 |
| GO:BP | GO:0006793 | phosphorus metabolic process | 1078 | 1904 | 3.53e-06 |
| GO:BP | GO:0001704 | formation of primary germ layer | 73 | 94 | 3.59e-06 |
| GO:BP | GO:0042592 | homeostatic process | 665 | 1137 | 3.62e-06 |
| GO:BP | GO:0030111 | regulation of Wnt signaling pathway | 175 | 261 | 3.77e-06 |
| GO:BP | GO:0072028 | nephron morphogenesis | 49 | 58 | 3.81e-06 |
| GO:BP | GO:0061333 | renal tubule morphogenesis | 49 | 58 | 3.81e-06 |
| GO:BP | GO:0048844 | artery morphogenesis | 49 | 58 | 3.81e-06 |
| GO:BP | GO:0045765 | regulation of angiogenesis | 135 | 194 | 3.94e-06 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | 69 | 88 | 3.99e-06 |
| GO:BP | GO:0051924 | regulation of calcium ion transport | 110 | 153 | 4.04e-06 |
| GO:BP | GO:0060415 | muscle tissue morphogenesis | 51 | 61 | 4.12e-06 |
| GO:BP | GO:0061337 | cardiac conduction | 67 | 85 | 4.17e-06 |
| GO:BP | GO:0048644 | muscle organ morphogenesis | 53 | 64 | 4.37e-06 |
| GO:BP | GO:0072080 | nephron tubule development | 57 | 70 | 4.61e-06 |
| GO:BP | GO:0042391 | regulation of membrane potential | 187 | 282 | 4.61e-06 |
| GO:BP | GO:0030509 | BMP signaling pathway | 83 | 110 | 4.62e-06 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 2690 | 4988 | 5.01e-06 |
| GO:BP | GO:0022612 | gland morphogenesis | 72 | 93 | 5.24e-06 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | 300 | 479 | 5.24e-06 |
| GO:BP | GO:0042060 | wound healing | 192 | 291 | 5.39e-06 |
| GO:BP | GO:0048167 | regulation of synaptic plasticity | 101 | 139 | 5.46e-06 |
| GO:BP | GO:0001952 | regulation of cell-matrix adhesion | 70 | 90 | 5.56e-06 |
| GO:BP | GO:0000165 | MAPK cascade | 314 | 504 | 5.56e-06 |
| GO:BP | GO:0022409 | positive regulation of cell-cell adhesion | 123 | 175 | 5.72e-06 |
| GO:BP | GO:0070252 | actin-mediated cell contraction | 68 | 87 | 5.90e-06 |
| GO:BP | GO:0060070 | canonical Wnt signaling pathway | 163 | 242 | 6.11e-06 |
| GO:BP | GO:0072009 | nephron epithelium development | 66 | 84 | 6.22e-06 |
| GO:BP | GO:0014070 | response to organic cyclic compound | 371 | 606 | 6.31e-06 |
| GO:BP | GO:0060412 | ventricular septum morphogenesis | 36 | 40 | 6.35e-06 |
| GO:BP | GO:0060421 | positive regulation of heart growth | 27 | 28 | 6.52e-06 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | 391 | 642 | 6.52e-06 |
| GO:BP | GO:0009987 | cellular process | 5561 | 10686 | 6.84e-06 |
| GO:BP | GO:0021915 | neural tube development | 97 | 133 | 6.88e-06 |
| GO:BP | GO:0090288 | negative regulation of cellular response to growth factor stimulus | 60 | 75 | 6.88e-06 |
| GO:BP | GO:0006941 | striated muscle contraction | 105 | 146 | 7.11e-06 |
| GO:BP | GO:0001838 | embryonic epithelial tube formation | 80 | 106 | 7.20e-06 |
| GO:BP | GO:0031214 | biomineral tissue development | 80 | 106 | 7.20e-06 |
| GO:BP | GO:0018212 | peptidyl-tyrosine modification | 116 | 164 | 7.20e-06 |
| GO:BP | GO:0051336 | regulation of hydrolase activity | 272 | 431 | 7.29e-06 |
| GO:BP | GO:0001934 | positive regulation of protein phosphorylation | 252 | 396 | 7.41e-06 |
| GO:BP | GO:0090100 | positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 67 | 86 | 8.72e-06 |
| GO:BP | GO:0050803 | regulation of synapse structure or activity | 123 | 176 | 9.02e-06 |
| GO:BP | GO:0072088 | nephron epithelium morphogenesis | 47 | 56 | 9.52e-06 |
| GO:BP | GO:0060048 | cardiac muscle contraction | 86 | 116 | 9.88e-06 |
| GO:BP | GO:0050807 | regulation of synapse organization | 121 | 173 | 1.04e-05 |
| GO:BP | GO:0002521 | leukocyte differentiation | 237 | 371 | 1.07e-05 |
| GO:BP | GO:1904062 | regulation of monoatomic cation transmembrane transport | 130 | 188 | 1.07e-05 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | 196 | 300 | 1.09e-05 |
| GO:BP | GO:1903530 | regulation of secretion by cell | 234 | 366 | 1.14e-05 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | 172 | 259 | 1.15e-05 |
| GO:BP | GO:0009628 | response to abiotic stimulus | 483 | 811 | 1.16e-05 |
| GO:BP | GO:0035108 | limb morphogenesis | 82 | 110 | 1.22e-05 |
| GO:BP | GO:0035107 | appendage morphogenesis | 82 | 110 | 1.22e-05 |
| GO:BP | GO:0060420 | regulation of heart growth | 42 | 49 | 1.23e-05 |
| GO:BP | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 108 | 152 | 1.24e-05 |
| GO:BP | GO:0060045 | positive regulation of cardiac muscle cell proliferation | 22 | 22 | 1.24e-05 |
| GO:BP | GO:0003148 | outflow tract septum morphogenesis | 22 | 22 | 1.24e-05 |
| GO:BP | GO:0009612 | response to mechanical stimulus | 108 | 152 | 1.24e-05 |
| GO:BP | GO:0060840 | artery development | 66 | 85 | 1.28e-05 |
| GO:BP | GO:0042325 | regulation of phosphorylation | 412 | 683 | 1.28e-05 |
| GO:BP | GO:0018108 | peptidyl-tyrosine phosphorylation | 114 | 162 | 1.32e-05 |
| GO:BP | GO:0060043 | regulation of cardiac muscle cell proliferation | 29 | 31 | 1.32e-05 |
| GO:BP | GO:0002065 | columnar/cuboidal epithelial cell differentiation | 64 | 82 | 1.35e-05 |
| GO:BP | GO:0051173 | positive regulation of nitrogen compound metabolic process | 1222 | 2186 | 1.35e-05 |
| GO:BP | GO:1903037 | regulation of leukocyte cell-cell adhesion | 135 | 197 | 1.39e-05 |
| GO:BP | GO:0003179 | heart valve morphogenesis | 46 | 55 | 1.49e-05 |
| GO:BP | GO:0060395 | SMAD protein signal transduction | 60 | 76 | 1.50e-05 |
| GO:BP | GO:0098771 | inorganic ion homeostasis | 223 | 348 | 1.58e-05 |
| GO:BP | GO:0007160 | cell-matrix adhesion | 118 | 169 | 1.58e-05 |
| GO:BP | GO:0048588 | developmental cell growth | 124 | 179 | 1.61e-05 |
| GO:BP | GO:0055074 | calcium ion homeostasis | 146 | 216 | 1.71e-05 |
| GO:BP | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 81 | 109 | 1.72e-05 |
| GO:BP | GO:0007498 | mesoderm development | 65 | 84 | 1.90e-05 |
| GO:BP | GO:0032409 | regulation of transporter activity | 105 | 148 | 1.92e-05 |
| GO:BP | GO:0097553 | calcium ion transmembrane import into cytosol | 89 | 122 | 1.92e-05 |
| GO:BP | GO:0050806 | positive regulation of synaptic transmission | 79 | 106 | 1.92e-05 |
| GO:BP | GO:0110110 | positive regulation of animal organ morphogenesis | 25 | 26 | 2.07e-05 |
| GO:BP | GO:0043270 | positive regulation of monoatomic ion transport | 92 | 127 | 2.10e-05 |
| GO:BP | GO:0032330 | regulation of chondrocyte differentiation | 31 | 34 | 2.12e-05 |
| GO:BP | GO:0003161 | cardiac conduction system development | 31 | 34 | 2.12e-05 |
| GO:BP | GO:0050678 | regulation of epithelial cell proliferation | 165 | 249 | 2.25e-05 |
| GO:BP | GO:0090066 | regulation of anatomical structure size | 240 | 379 | 2.29e-05 |
| GO:BP | GO:1905314 | semi-lunar valve development | 36 | 41 | 2.29e-05 |
| GO:BP | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 45 | 54 | 2.33e-05 |
| GO:BP | GO:0072078 | nephron tubule morphogenesis | 45 | 54 | 2.33e-05 |
| GO:BP | GO:0014910 | regulation of smooth muscle cell migration | 45 | 54 | 2.33e-05 |
| GO:BP | GO:0010817 | regulation of hormone levels | 205 | 318 | 2.33e-05 |
| GO:BP | GO:0048660 | regulation of smooth muscle cell proliferation | 73 | 97 | 2.61e-05 |
| GO:BP | GO:0048732 | gland development | 199 | 308 | 2.64e-05 |
| GO:BP | GO:0006874 | intracellular calcium ion homeostasis | 137 | 202 | 2.70e-05 |
| GO:BP | GO:0046879 | hormone secretion | 137 | 202 | 2.70e-05 |
| GO:BP | GO:0048771 | tissue remodeling | 83 | 113 | 2.73e-05 |
| GO:BP | GO:0048754 | branching morphogenesis of an epithelial tube | 83 | 113 | 2.73e-05 |
| GO:BP | GO:0055010 | ventricular cardiac muscle tissue morphogenesis | 38 | 44 | 2.74e-05 |
| GO:BP | GO:0022898 | regulation of transmembrane transporter activity | 99 | 139 | 2.85e-05 |
| GO:BP | GO:0031346 | positive regulation of cell projection organization | 186 | 286 | 3.07e-05 |
| GO:BP | GO:0048041 | focal adhesion assembly | 60 | 77 | 3.18e-05 |
| GO:BP | GO:0050865 | regulation of cell activation | 221 | 347 | 3.25e-05 |
| GO:BP | GO:0099003 | vesicle-mediated transport in synapse | 117 | 169 | 3.29e-05 |
| GO:BP | GO:0001649 | osteoblast differentiation | 120 | 174 | 3.29e-05 |
| GO:BP | GO:0015833 | peptide transport | 123 | 179 | 3.29e-05 |
| GO:BP | GO:0031644 | regulation of nervous system process | 58 | 74 | 3.33e-05 |
| GO:BP | GO:0048864 | stem cell development | 58 | 74 | 3.33e-05 |
| GO:BP | GO:0042471 | ear morphogenesis | 58 | 74 | 3.33e-05 |
| GO:BP | GO:0046649 | lymphocyte activation | 276 | 444 | 3.36e-05 |
| GO:BP | GO:0048592 | eye morphogenesis | 79 | 107 | 3.41e-05 |
| GO:BP | GO:0055023 | positive regulation of cardiac muscle tissue growth | 24 | 25 | 3.65e-05 |
| GO:BP | GO:0003170 | heart valve development | 52 | 65 | 3.77e-05 |
| GO:BP | GO:0043087 | regulation of GTPase activity | 115 | 166 | 3.77e-05 |
| GO:BP | GO:0035296 | regulation of tube diameter | 75 | 101 | 4.29e-05 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | 125 | 183 | 4.29e-05 |
| GO:BP | GO:0035150 | regulation of tube size | 75 | 101 | 4.29e-05 |
| GO:BP | GO:0097746 | blood vessel diameter maintenance | 75 | 101 | 4.29e-05 |
| GO:BP | GO:0030178 | negative regulation of Wnt signaling pathway | 96 | 135 | 4.45e-05 |
| GO:BP | GO:0006813 | potassium ion transport | 96 | 135 | 4.45e-05 |
| GO:BP | GO:0003002 | regionalization | 169 | 258 | 4.65e-05 |
| GO:BP | GO:0010634 | positive regulation of epithelial cell migration | 91 | 127 | 4.83e-05 |
| GO:BP | GO:0050878 | regulation of body fluid levels | 152 | 229 | 4.83e-05 |
| GO:BP | GO:0009914 | hormone transport | 139 | 207 | 5.02e-05 |
| GO:BP | GO:0072171 | mesonephric tubule morphogenesis | 39 | 46 | 5.02e-05 |
| GO:BP | GO:0048878 | chemical homeostasis | 401 | 670 | 5.04e-05 |
| GO:BP | GO:0048638 | regulation of developmental growth | 160 | 243 | 5.41e-05 |
| GO:BP | GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction | 143 | 214 | 5.43e-05 |
| GO:BP | GO:0071407 | cellular response to organic cyclic compound | 238 | 379 | 5.89e-05 |
| GO:BP | GO:0072091 | regulation of stem cell proliferation | 49 | 61 | 5.89e-05 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | 1040 | 1856 | 6.19e-05 |
| GO:BP | GO:0030097 | hemopoiesis | 375 | 624 | 6.22e-05 |
| GO:BP | GO:0060078 | regulation of postsynaptic membrane potential | 60 | 78 | 6.44e-05 |
| GO:BP | GO:0031032 | actomyosin structure organization | 125 | 184 | 6.44e-05 |
| GO:BP | GO:0003272 | endocardial cushion formation | 23 | 24 | 6.53e-05 |
| GO:BP | GO:0051345 | positive regulation of hydrolase activity | 173 | 266 | 6.68e-05 |
| GO:BP | GO:0010628 | positive regulation of gene expression | 442 | 746 | 6.76e-05 |
| GO:BP | GO:0048736 | appendage development | 96 | 136 | 7.25e-05 |
| GO:BP | GO:0060173 | limb development | 96 | 136 | 7.25e-05 |
| GO:BP | GO:0014812 | muscle cell migration | 56 | 72 | 7.43e-05 |
| GO:BP | GO:0031328 | positive regulation of cellular biosynthetic process | 1031 | 1841 | 7.75e-05 |
| GO:BP | GO:0003184 | pulmonary valve morphogenesis | 19 | 19 | 7.75e-05 |
| GO:BP | GO:0014032 | neural crest cell development | 54 | 69 | 7.88e-05 |
| GO:BP | GO:0006939 | smooth muscle contraction | 54 | 69 | 7.88e-05 |
| GO:BP | GO:0060675 | ureteric bud morphogenesis | 38 | 45 | 8.03e-05 |
| GO:BP | GO:1902107 | positive regulation of leukocyte differentiation | 83 | 115 | 8.09e-05 |
| GO:BP | GO:1903708 | positive regulation of hemopoiesis | 83 | 115 | 8.09e-05 |
| GO:BP | GO:0042110 | T cell activation | 195 | 305 | 8.59e-05 |
| GO:BP | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 40 | 48 | 8.60e-05 |
| GO:BP | GO:0021953 | central nervous system neuron differentiation | 73 | 99 | 8.60e-05 |
| GO:BP | GO:0071805 | potassium ion transmembrane transport | 86 | 120 | 8.61e-05 |
| GO:BP | GO:0055001 | muscle cell development | 112 | 163 | 8.88e-05 |
| GO:BP | GO:0001707 | mesoderm formation | 42 | 51 | 8.89e-05 |
| GO:BP | GO:0014909 | smooth muscle cell migration | 48 | 60 | 8.89e-05 |
| GO:BP | GO:0072132 | mesenchyme morphogenesis | 42 | 51 | 8.89e-05 |
| GO:BP | GO:0045666 | positive regulation of neuron differentiation | 46 | 57 | 9.01e-05 |
| GO:BP | GO:0043067 | regulation of programmed cell death | 612 | 1060 | 9.15e-05 |
| GO:BP | GO:0070372 | regulation of ERK1 and ERK2 cascade | 119 | 175 | 9.88e-05 |
| GO:BP | GO:0006949 | syncytium formation | 33 | 38 | 1.00e-04 |
| GO:BP | GO:0031345 | negative regulation of cell projection organization | 101 | 145 | 1.01e-04 |
| GO:BP | GO:0050790 | regulation of catalytic activity | 521 | 893 | 1.02e-04 |
| GO:BP | GO:0008544 | epidermis development | 139 | 209 | 1.04e-04 |
| GO:BP | GO:0008150 | biological_process | 5821 | 11244 | 1.13e-04 |
| GO:BP | GO:0061036 | positive regulation of cartilage development | 22 | 23 | 1.15e-04 |
| GO:BP | GO:0002063 | chondrocyte development | 22 | 23 | 1.15e-04 |
| GO:BP | GO:0070371 | ERK1 and ERK2 cascade | 130 | 194 | 1.16e-04 |
| GO:BP | GO:0060541 | respiratory system development | 111 | 162 | 1.17e-04 |
| GO:BP | GO:0048639 | positive regulation of developmental growth | 85 | 119 | 1.18e-04 |
| GO:BP | GO:0045667 | regulation of osteoblast differentiation | 72 | 98 | 1.21e-04 |
| GO:BP | GO:0030010 | establishment of cell polarity | 88 | 124 | 1.24e-04 |
| GO:BP | GO:0055021 | regulation of cardiac muscle tissue growth | 37 | 44 | 1.27e-04 |
| GO:BP | GO:0060976 | coronary vasculature development | 37 | 44 | 1.27e-04 |
| GO:BP | GO:0042981 | regulation of apoptotic process | 595 | 1031 | 1.31e-04 |
| GO:BP | GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 94 | 134 | 1.31e-04 |
| GO:BP | GO:0046883 | regulation of hormone secretion | 112 | 164 | 1.33e-04 |
| GO:BP | GO:0014855 | striated muscle cell proliferation | 47 | 59 | 1.34e-04 |
| GO:BP | GO:0060828 | regulation of canonical Wnt signaling pathway | 135 | 203 | 1.39e-04 |
| GO:BP | GO:0048332 | mesoderm morphogenesis | 43 | 53 | 1.39e-04 |
| GO:BP | GO:0051249 | regulation of lymphocyte activation | 179 | 279 | 1.47e-04 |
| GO:BP | GO:0003158 | endothelium development | 73 | 100 | 1.50e-04 |
| GO:BP | GO:0002790 | peptide secretion | 113 | 166 | 1.52e-04 |
| GO:BP | GO:0010594 | regulation of endothelial cell migration | 95 | 136 | 1.54e-04 |
| GO:BP | GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 101 | 146 | 1.57e-04 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | 1001 | 1791 | 1.61e-04 |
| GO:BP | GO:0003176 | aortic valve development | 32 | 37 | 1.63e-04 |
| GO:BP | GO:0055007 | cardiac muscle cell differentiation | 76 | 105 | 1.63e-04 |
| GO:BP | GO:0050708 | regulation of protein secretion | 120 | 178 | 1.64e-04 |
| GO:BP | GO:0021537 | telencephalon development | 130 | 195 | 1.66e-04 |
| GO:BP | GO:0019722 | calcium-mediated signaling | 87 | 123 | 1.67e-04 |
| GO:BP | GO:0030513 | positive regulation of BMP signaling pathway | 27 | 30 | 1.72e-04 |
| GO:BP | GO:0048705 | skeletal system morphogenesis | 102 | 148 | 1.81e-04 |
| GO:BP | GO:0002694 | regulation of leukocyte activation | 198 | 313 | 1.85e-04 |
| GO:BP | GO:0050770 | regulation of axonogenesis | 88 | 125 | 2.00e-04 |
| GO:BP | GO:0048663 | neuron fate commitment | 24 | 26 | 2.04e-04 |
| GO:BP | GO:0010092 | specification of animal organ identity | 24 | 26 | 2.04e-04 |
| GO:BP | GO:0003177 | pulmonary valve development | 21 | 22 | 2.04e-04 |
| GO:BP | GO:0050870 | positive regulation of T cell activation | 94 | 135 | 2.07e-04 |
| GO:BP | GO:0051893 | regulation of focal adhesion assembly | 44 | 55 | 2.09e-04 |
| GO:BP | GO:0003197 | endocardial cushion development | 38 | 46 | 2.09e-04 |
| GO:BP | GO:0090109 | regulation of cell-substrate junction assembly | 44 | 55 | 2.09e-04 |
| GO:BP | GO:0060390 | regulation of SMAD protein signal transduction | 40 | 49 | 2.13e-04 |
| GO:BP | GO:1902105 | regulation of leukocyte differentiation | 129 | 194 | 2.14e-04 |
| GO:BP | GO:0071692 | protein localization to extracellular region | 165 | 256 | 2.18e-04 |
| GO:BP | GO:2000648 | positive regulation of stem cell proliferation | 29 | 33 | 2.21e-04 |
| GO:BP | GO:0003180 | aortic valve morphogenesis | 29 | 33 | 2.21e-04 |
| GO:BP | GO:0061572 | actin filament bundle organization | 92 | 132 | 2.37e-04 |
| GO:BP | GO:0002573 | myeloid leukocyte differentiation | 104 | 152 | 2.37e-04 |
| GO:BP | GO:0070482 | response to oxygen levels | 170 | 265 | 2.39e-04 |
| GO:BP | GO:0048565 | digestive tract development | 65 | 88 | 2.39e-04 |
| GO:BP | GO:0001935 | endothelial cell proliferation | 81 | 114 | 2.51e-04 |
| GO:BP | GO:0036211 | protein modification process | 1263 | 2291 | 2.54e-04 |
| GO:BP | GO:0048659 | smooth muscle cell proliferation | 73 | 101 | 2.55e-04 |
| GO:BP | GO:0060445 | branching involved in salivary gland morphogenesis | 17 | 17 | 2.58e-04 |
| GO:BP | GO:0061351 | neural precursor cell proliferation | 84 | 119 | 2.60e-04 |
| GO:BP | GO:0140253 | cell-cell fusion | 31 | 36 | 2.61e-04 |
| GO:BP | GO:0038084 | vascular endothelial growth factor signaling pathway | 31 | 36 | 2.61e-04 |
| GO:BP | GO:0000768 | syncytium formation by plasma membrane fusion | 31 | 36 | 2.61e-04 |
| GO:BP | GO:0010463 | mesenchymal cell proliferation | 31 | 36 | 2.61e-04 |
| GO:BP | GO:0045446 | endothelial cell differentiation | 63 | 85 | 2.66e-04 |
| GO:BP | GO:0007492 | endoderm development | 49 | 63 | 2.68e-04 |
| GO:BP | GO:0007043 | cell-cell junction assembly | 76 | 106 | 2.70e-04 |
| GO:BP | GO:1990138 | neuron projection extension | 93 | 134 | 2.72e-04 |
| GO:BP | GO:0150116 | regulation of cell-substrate junction organization | 47 | 60 | 2.85e-04 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | 47 | 60 | 2.85e-04 |
| GO:BP | GO:0002040 | sprouting angiogenesis | 71 | 98 | 2.87e-04 |
| GO:BP | GO:0001658 | branching involved in ureteric bud morphogenesis | 33 | 39 | 2.90e-04 |
| GO:BP | GO:0071774 | response to fibroblast growth factor | 61 | 82 | 2.96e-04 |
| GO:BP | GO:0051283 | negative regulation of sequestering of calcium ion | 66 | 90 | 2.96e-04 |
| GO:BP | GO:0071559 | response to transforming growth factor beta | 143 | 219 | 2.97e-04 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | 177 | 278 | 2.97e-04 |
| GO:BP | GO:0006954 | inflammatory response | 260 | 425 | 3.08e-04 |
| GO:BP | GO:0032835 | glomerulus development | 43 | 54 | 3.11e-04 |
| GO:BP | GO:0086065 | cell communication involved in cardiac conduction | 43 | 54 | 3.11e-04 |
| GO:BP | GO:0051017 | actin filament bundle assembly | 91 | 131 | 3.11e-04 |
| GO:BP | GO:1903169 | regulation of calcium ion transmembrane transport | 77 | 108 | 3.23e-04 |
| GO:BP | GO:0042476 | odontogenesis | 59 | 79 | 3.27e-04 |
| GO:BP | GO:0044344 | cellular response to fibroblast growth factor stimulus | 59 | 79 | 3.27e-04 |
| GO:BP | GO:0048593 | camera-type eye morphogenesis | 64 | 87 | 3.30e-04 |
| GO:BP | GO:0014020 | primary neural tube formation | 64 | 87 | 3.30e-04 |
| GO:BP | GO:0030326 | embryonic limb morphogenesis | 64 | 87 | 3.30e-04 |
| GO:BP | GO:0035113 | embryonic appendage morphogenesis | 64 | 87 | 3.30e-04 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | 167 | 261 | 3.35e-04 |
| GO:BP | GO:0050863 | regulation of T cell activation | 134 | 204 | 3.45e-04 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | 263 | 431 | 3.51e-04 |
| GO:BP | GO:0002064 | epithelial cell development | 101 | 148 | 3.51e-04 |
| GO:BP | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 95 | 138 | 3.58e-04 |
| GO:BP | GO:0001841 | neural tube formation | 67 | 92 | 3.63e-04 |
| GO:BP | GO:0010721 | negative regulation of cell development | 121 | 182 | 3.74e-04 |
| GO:BP | GO:0060349 | bone morphogenesis | 55 | 73 | 4.03e-04 |
| GO:BP | GO:0051209 | release of sequestered calcium ion into cytosol | 65 | 89 | 4.13e-04 |
| GO:BP | GO:0006942 | regulation of striated muscle contraction | 60 | 81 | 4.16e-04 |
| GO:BP | GO:0045860 | positive regulation of protein kinase activity | 122 | 184 | 4.16e-04 |
| GO:BP | GO:0046622 | positive regulation of organ growth | 30 | 35 | 4.16e-04 |
| GO:BP | GO:0030072 | peptide hormone secretion | 109 | 162 | 4.32e-04 |
| GO:BP | GO:0071560 | cellular response to transforming growth factor beta stimulus | 140 | 215 | 4.32e-04 |
| GO:BP | GO:0045444 | fat cell differentiation | 119 | 179 | 4.33e-04 |
| GO:BP | GO:0098659 | inorganic cation import across plasma membrane | 53 | 70 | 4.40e-04 |
| GO:BP | GO:0016049 | cell growth | 235 | 382 | 4.40e-04 |
| GO:BP | GO:0099565 | chemical synaptic transmission, postsynaptic | 53 | 70 | 4.40e-04 |
| GO:BP | GO:0099587 | inorganic ion import across plasma membrane | 53 | 70 | 4.40e-04 |
| GO:BP | GO:0043616 | keratinocyte proliferation | 32 | 38 | 4.56e-04 |
| GO:BP | GO:0099173 | postsynapse organization | 100 | 147 | 4.61e-04 |
| GO:BP | GO:0050679 | positive regulation of epithelial cell proliferation | 97 | 142 | 4.69e-04 |
| GO:BP | GO:2000463 | positive regulation of excitatory postsynaptic potential | 25 | 28 | 4.70e-04 |
| GO:BP | GO:0098739 | import across plasma membrane | 85 | 122 | 4.70e-04 |
| GO:BP | GO:0030073 | insulin secretion | 94 | 137 | 4.72e-04 |
| GO:BP | GO:0098815 | modulation of excitatory postsynaptic potential | 34 | 41 | 4.78e-04 |
| GO:BP | GO:1905330 | regulation of morphogenesis of an epithelium | 34 | 41 | 4.78e-04 |
| GO:BP | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 40 | 50 | 4.78e-04 |
| GO:BP | GO:0034332 | adherens junction organization | 36 | 44 | 4.89e-04 |
| GO:BP | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 66 | 91 | 5.02e-04 |
| GO:BP | GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 66 | 91 | 5.02e-04 |
| GO:BP | GO:0009306 | protein secretion | 161 | 252 | 5.06e-04 |
| GO:BP | GO:0035592 | establishment of protein localization to extracellular region | 161 | 252 | 5.06e-04 |
| GO:BP | GO:0086003 | cardiac muscle cell contraction | 49 | 64 | 5.24e-04 |
| GO:BP | GO:0016358 | dendrite development | 121 | 183 | 5.26e-04 |
| GO:BP | GO:0030324 | lung development | 98 | 144 | 5.28e-04 |
| GO:BP | GO:0055123 | digestive system development | 69 | 96 | 5.36e-04 |
| GO:BP | GO:0061614 | miRNA transcription | 47 | 61 | 5.69e-04 |
| GO:BP | GO:0042063 | gliogenesis | 155 | 242 | 5.80e-04 |
| GO:BP | GO:0051251 | positive regulation of lymphocyte activation | 122 | 185 | 5.82e-04 |
| GO:BP | GO:0030098 | lymphocyte differentiation | 159 | 249 | 5.83e-04 |
| GO:BP | GO:0042886 | amide transport | 133 | 204 | 6.02e-04 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | 378 | 642 | 6.10e-04 |
| GO:BP | GO:0016192 | vesicle-mediated transport | 654 | 1152 | 6.14e-04 |
| GO:BP | GO:1904018 | positive regulation of vasculature development | 81 | 116 | 6.18e-04 |
| GO:BP | GO:0007416 | synapse assembly | 93 | 136 | 6.18e-04 |
| GO:BP | GO:0051051 | negative regulation of transport | 180 | 286 | 6.18e-04 |
| GO:BP | GO:0051235 | maintenance of location | 160 | 251 | 6.25e-04 |
| GO:BP | GO:0032526 | response to retinoic acid | 57 | 77 | 6.51e-04 |
| GO:BP | GO:0001666 | response to hypoxia | 149 | 232 | 6.58e-04 |
| GO:BP | GO:0006898 | receptor-mediated endocytosis | 120 | 182 | 6.71e-04 |
| GO:BP | GO:0030323 | respiratory tube development | 100 | 148 | 6.76e-04 |
| GO:BP | GO:0001708 | cell fate specification | 41 | 52 | 6.91e-04 |
| GO:BP | GO:0001570 | vasculogenesis | 50 | 66 | 6.93e-04 |
| GO:BP | GO:0050796 | regulation of insulin secretion | 79 | 113 | 7.12e-04 |
| GO:BP | GO:0050920 | regulation of chemotaxis | 91 | 133 | 7.15e-04 |
| GO:BP | GO:0030100 | regulation of endocytosis | 128 | 196 | 7.32e-04 |
| GO:BP | GO:0071526 | semaphorin-plexin signaling pathway | 35 | 43 | 7.54e-04 |
| GO:BP | GO:0036293 | response to decreased oxygen levels | 155 | 243 | 7.73e-04 |
| GO:BP | GO:0050801 | monoatomic ion homeostasis | 247 | 406 | 7.73e-04 |
| GO:BP | GO:0007215 | glutamate receptor signaling pathway | 24 | 27 | 7.79e-04 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | 262 | 433 | 7.82e-04 |
| GO:BP | GO:0043542 | endothelial cell migration | 115 | 174 | 8.14e-04 |
| GO:BP | GO:0006836 | neurotransmitter transport | 92 | 135 | 8.15e-04 |
| GO:BP | GO:0002761 | regulation of myeloid leukocyte differentiation | 58 | 79 | 8.16e-04 |
| GO:BP | GO:0071375 | cellular response to peptide hormone stimulus | 148 | 231 | 8.16e-04 |
| GO:BP | GO:0009410 | response to xenobiotic stimulus | 172 | 273 | 8.17e-04 |
| GO:BP | GO:0034764 | positive regulation of transmembrane transport | 89 | 130 | 8.22e-04 |
| GO:BP | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 86 | 125 | 8.28e-04 |
| GO:BP | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 66 | 92 | 8.36e-04 |
| GO:BP | GO:0051282 | regulation of sequestering of calcium ion | 66 | 92 | 8.36e-04 |
| GO:BP | GO:0001759 | organ induction | 15 | 15 | 8.36e-04 |
| GO:BP | GO:0022604 | regulation of cell morphogenesis | 126 | 193 | 8.37e-04 |
| GO:BP | GO:0010001 | glial cell differentiation | 119 | 181 | 8.45e-04 |
| GO:BP | GO:0051896 | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 119 | 181 | 8.45e-04 |
| GO:BP | GO:0060606 | tube closure | 61 | 84 | 8.84e-04 |
| GO:BP | GO:0035270 | endocrine system development | 61 | 84 | 8.84e-04 |
| GO:BP | GO:0010876 | lipid localization | 186 | 298 | 8.84e-04 |
| GO:BP | GO:0043434 | response to peptide hormone | 195 | 314 | 8.99e-04 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | 329 | 555 | 9.01e-04 |
| GO:BP | GO:0051963 | regulation of synapse assembly | 56 | 76 | 9.06e-04 |
| GO:BP | GO:1901890 | positive regulation of cell junction assembly | 56 | 76 | 9.06e-04 |
| GO:BP | GO:0060914 | heart formation | 26 | 30 | 9.27e-04 |
| GO:BP | GO:0002791 | regulation of peptide secretion | 90 | 132 | 9.27e-04 |
| GO:BP | GO:0042475 | odontogenesis of dentin-containing tooth | 42 | 54 | 9.55e-04 |
| GO:BP | GO:0055117 | regulation of cardiac muscle contraction | 49 | 65 | 9.86e-04 |
| GO:BP | GO:0060079 | excitatory postsynaptic potential | 49 | 65 | 9.86e-04 |
| GO:BP | GO:0033674 | positive regulation of kinase activity | 128 | 197 | 9.95e-04 |
| GO:BP | GO:0051047 | positive regulation of secretion | 132 | 204 | 1.02e-03 |
| GO:BP | GO:0030031 | cell projection assembly | 269 | 447 | 1.03e-03 |
| GO:BP | GO:1901652 | response to peptide | 225 | 368 | 1.03e-03 |
| GO:BP | GO:0032924 | activin receptor signaling pathway | 28 | 33 | 1.04e-03 |
| GO:BP | GO:0003156 | regulation of animal organ formation | 18 | 19 | 1.06e-03 |
| GO:BP | GO:0001764 | neuron migration | 88 | 129 | 1.07e-03 |
| GO:BP | GO:0001755 | neural crest cell migration | 38 | 48 | 1.07e-03 |
| GO:BP | GO:0051058 | negative regulation of small GTPase mediated signal transduction | 38 | 48 | 1.07e-03 |
| GO:BP | GO:0140115 | export across plasma membrane | 38 | 48 | 1.07e-03 |
| GO:BP | GO:0051961 | negative regulation of nervous system development | 76 | 109 | 1.08e-03 |
| GO:BP | GO:0070167 | regulation of biomineral tissue development | 47 | 62 | 1.08e-03 |
| GO:BP | GO:0099504 | synaptic vesicle cycle | 101 | 151 | 1.08e-03 |
| GO:BP | GO:0045766 | positive regulation of angiogenesis | 79 | 114 | 1.08e-03 |
| GO:BP | GO:0003203 | endocardial cushion morphogenesis | 30 | 36 | 1.10e-03 |
| GO:BP | GO:0002376 | immune system process | 789 | 1410 | 1.12e-03 |
| GO:BP | GO:0046632 | alpha-beta T cell differentiation | 52 | 70 | 1.13e-03 |
| GO:BP | GO:0046620 | regulation of organ growth | 52 | 70 | 1.13e-03 |
| GO:BP | GO:0040008 | regulation of growth | 277 | 462 | 1.13e-03 |
| GO:BP | GO:0060627 | regulation of vesicle-mediated transport | 228 | 374 | 1.17e-03 |
| GO:BP | GO:0001936 | regulation of endothelial cell proliferation | 68 | 96 | 1.18e-03 |
| GO:BP | GO:0055080 | monoatomic cation homeostasis | 243 | 401 | 1.19e-03 |
| GO:BP | GO:0120031 | plasma membrane bounded cell projection assembly | 263 | 437 | 1.19e-03 |
| GO:BP | GO:0051641 | cellular localization | 1428 | 2623 | 1.19e-03 |
| GO:BP | GO:0007611 | learning or memory | 123 | 189 | 1.20e-03 |
| GO:BP | GO:0001843 | neural tube closure | 60 | 83 | 1.20e-03 |
| GO:BP | GO:0002027 | regulation of heart rate | 60 | 83 | 1.20e-03 |
| GO:BP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 77 | 111 | 1.24e-03 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | 363 | 619 | 1.24e-03 |
| GO:BP | GO:2000181 | negative regulation of blood vessel morphogenesis | 50 | 67 | 1.25e-03 |
| GO:BP | GO:0051588 | regulation of neurotransmitter transport | 50 | 67 | 1.25e-03 |
| GO:BP | GO:1901343 | negative regulation of vasculature development | 50 | 67 | 1.25e-03 |
| GO:BP | GO:0014896 | muscle hypertrophy | 55 | 75 | 1.25e-03 |
| GO:BP | GO:0050867 | positive regulation of cell activation | 131 | 203 | 1.25e-03 |
| GO:BP | GO:0045927 | positive regulation of growth | 120 | 184 | 1.26e-03 |
| GO:BP | GO:0046928 | regulation of neurotransmitter secretion | 43 | 56 | 1.27e-03 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | 53 | 72 | 1.42e-03 |
| GO:BP | GO:0014902 | myotube differentiation | 61 | 85 | 1.47e-03 |
| GO:BP | GO:1902414 | protein localization to cell junction | 61 | 85 | 1.47e-03 |
| GO:BP | GO:0060563 | neuroepithelial cell differentiation | 25 | 29 | 1.48e-03 |
| GO:BP | GO:0007520 | myoblast fusion | 25 | 29 | 1.48e-03 |
| GO:BP | GO:0090497 | mesenchymal cell migration | 39 | 50 | 1.49e-03 |
| GO:BP | GO:0023019 | signal transduction involved in regulation of gene expression | 14 | 14 | 1.50e-03 |
| GO:BP | GO:0009991 | response to extracellular stimulus | 229 | 377 | 1.51e-03 |
| GO:BP | GO:0090276 | regulation of peptide hormone secretion | 88 | 130 | 1.57e-03 |
| GO:BP | GO:0046888 | negative regulation of hormone secretion | 37 | 47 | 1.58e-03 |
| GO:BP | GO:0031667 | response to nutrient levels | 216 | 354 | 1.61e-03 |
| GO:BP | GO:1905207 | regulation of cardiocyte differentiation | 20 | 22 | 1.61e-03 |
| GO:BP | GO:0048333 | mesodermal cell differentiation | 20 | 22 | 1.61e-03 |
| GO:BP | GO:1903779 | regulation of cardiac conduction | 20 | 22 | 1.61e-03 |
| GO:BP | GO:1902284 | neuron projection extension involved in neuron projection guidance | 27 | 32 | 1.63e-03 |
| GO:BP | GO:0048846 | axon extension involved in axon guidance | 27 | 32 | 1.63e-03 |
| GO:BP | GO:0086002 | cardiac muscle cell action potential involved in contraction | 35 | 44 | 1.66e-03 |
| GO:BP | GO:0002696 | positive regulation of leukocyte activation | 127 | 197 | 1.67e-03 |
| GO:BP | GO:0032414 | positive regulation of ion transmembrane transporter activity | 44 | 58 | 1.70e-03 |
| GO:BP | GO:0010812 | negative regulation of cell-substrate adhesion | 33 | 41 | 1.71e-03 |
| GO:BP | GO:0006814 | sodium ion transport | 92 | 137 | 1.71e-03 |
| GO:BP | GO:0048168 | regulation of neuronal synaptic plasticity | 31 | 38 | 1.72e-03 |
| GO:BP | GO:0048013 | ephrin receptor signaling pathway | 31 | 38 | 1.72e-03 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | 120 | 185 | 1.72e-03 |
| GO:BP | GO:0007613 | memory | 62 | 87 | 1.74e-03 |
| GO:BP | GO:0014897 | striated muscle hypertrophy | 54 | 74 | 1.74e-03 |
| GO:BP | GO:0016525 | negative regulation of angiogenesis | 49 | 66 | 1.76e-03 |
| GO:BP | GO:0018105 | peptidyl-serine phosphorylation | 106 | 161 | 1.78e-03 |
| GO:BP | GO:0001816 | cytokine production | 264 | 441 | 1.82e-03 |
| GO:BP | GO:0031099 | regeneration | 96 | 144 | 1.83e-03 |
| GO:BP | GO:0050890 | cognition | 136 | 213 | 1.83e-03 |
| GO:BP | GO:0007009 | plasma membrane organization | 74 | 107 | 1.89e-03 |
| GO:BP | GO:1903706 | regulation of hemopoiesis | 161 | 257 | 1.91e-03 |
| GO:BP | GO:0043535 | regulation of blood vessel endothelial cell migration | 52 | 71 | 1.97e-03 |
| GO:BP | GO:0090087 | regulation of peptide transport | 90 | 134 | 1.97e-03 |
| GO:BP | GO:0072089 | stem cell proliferation | 60 | 84 | 1.99e-03 |
| GO:BP | GO:0043500 | muscle adaptation | 63 | 89 | 2.08e-03 |
| GO:BP | GO:0010595 | positive regulation of endothelial cell migration | 63 | 89 | 2.08e-03 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | 884 | 1595 | 2.08e-03 |
| GO:BP | GO:0006470 | protein dephosphorylation | 115 | 177 | 2.11e-03 |
| GO:BP | GO:0006869 | lipid transport | 163 | 261 | 2.16e-03 |
| GO:BP | GO:0007266 | Rho protein signal transduction | 75 | 109 | 2.18e-03 |
| GO:BP | GO:0045685 | regulation of glial cell differentiation | 38 | 49 | 2.18e-03 |
| GO:BP | GO:1903053 | regulation of extracellular matrix organization | 38 | 49 | 2.18e-03 |
| GO:BP | GO:0099175 | regulation of postsynapse organization | 58 | 81 | 2.28e-03 |
| GO:BP | GO:1904064 | positive regulation of cation transmembrane transport | 58 | 81 | 2.28e-03 |
| GO:BP | GO:0060350 | endochondral bone morphogenesis | 36 | 46 | 2.34e-03 |
| GO:BP | GO:0097120 | receptor localization to synapse | 36 | 46 | 2.34e-03 |
| GO:BP | GO:0030947 | regulation of vascular endothelial growth factor receptor signaling pathway | 24 | 28 | 2.38e-03 |
| GO:BP | GO:0001817 | regulation of cytokine production | 261 | 437 | 2.39e-03 |
| GO:BP | GO:0009952 | anterior/posterior pattern specification | 82 | 121 | 2.41e-03 |
| GO:BP | GO:0003300 | cardiac muscle hypertrophy | 53 | 73 | 2.43e-03 |
| GO:BP | GO:0051208 | sequestering of calcium ion | 67 | 96 | 2.49e-03 |
| GO:BP | GO:0048813 | dendrite morphogenesis | 76 | 111 | 2.49e-03 |
| GO:BP | GO:0035023 | regulation of Rho protein signal transduction | 48 | 65 | 2.50e-03 |
| GO:BP | GO:0010644 | cell communication by electrical coupling | 26 | 31 | 2.56e-03 |
| GO:BP | GO:0071634 | regulation of transforming growth factor beta production | 26 | 31 | 2.56e-03 |
| GO:BP | GO:0050900 | leukocyte migration | 125 | 195 | 2.57e-03 |
| GO:BP | GO:0018209 | peptidyl-serine modification | 110 | 169 | 2.57e-03 |
| GO:BP | GO:0050795 | regulation of behavior | 32 | 40 | 2.58e-03 |
| GO:BP | GO:0055006 | cardiac cell development | 56 | 78 | 2.58e-03 |
| GO:BP | GO:0071868 | cellular response to monoamine stimulus | 28 | 34 | 2.64e-03 |
| GO:BP | GO:0071870 | cellular response to catecholamine stimulus | 28 | 34 | 2.64e-03 |
| GO:BP | GO:0061037 | negative regulation of cartilage development | 19 | 21 | 2.68e-03 |
| GO:BP | GO:0014912 | negative regulation of smooth muscle cell migration | 19 | 21 | 2.68e-03 |
| GO:BP | GO:0046631 | alpha-beta T cell activation | 62 | 88 | 2.81e-03 |
| GO:BP | GO:0043547 | positive regulation of GTPase activity | 77 | 113 | 2.83e-03 |
| GO:BP | GO:0045598 | regulation of fat cell differentiation | 65 | 93 | 2.86e-03 |
| GO:BP | GO:0050680 | negative regulation of epithelial cell proliferation | 68 | 98 | 2.89e-03 |
| GO:BP | GO:0050768 | negative regulation of neurogenesis | 71 | 103 | 2.89e-03 |
| GO:BP | GO:0033993 | response to lipid | 335 | 573 | 2.91e-03 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | 689 | 1231 | 2.92e-03 |
| GO:BP | GO:0019935 | cyclic-nucleotide-mediated signaling | 39 | 51 | 2.93e-03 |
| GO:BP | GO:1901653 | cellular response to peptide | 169 | 273 | 3.01e-03 |
| GO:BP | GO:0009725 | response to hormone | 355 | 610 | 3.06e-03 |
| GO:BP | GO:0140747 | regulation of ncRNA transcription | 57 | 80 | 3.10e-03 |
| GO:BP | GO:2001257 | regulation of cation channel activity | 49 | 67 | 3.10e-03 |
| GO:BP | GO:0060977 | coronary vasculature morphogenesis | 16 | 17 | 3.13e-03 |
| GO:BP | GO:0034505 | tooth mineralization | 16 | 17 | 3.13e-03 |
| GO:BP | GO:0003215 | cardiac right ventricle morphogenesis | 16 | 17 | 3.13e-03 |
| GO:BP | GO:0033135 | regulation of peptidyl-serine phosphorylation | 60 | 85 | 3.21e-03 |
| GO:BP | GO:0071396 | cellular response to lipid | 233 | 388 | 3.24e-03 |
| GO:BP | GO:0071496 | cellular response to external stimulus | 166 | 268 | 3.24e-03 |
| GO:BP | GO:0001890 | placenta development | 75 | 110 | 3.25e-03 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | 690 | 1234 | 3.30e-03 |
| GO:BP | GO:0032878 | regulation of establishment or maintenance of cell polarity | 21 | 24 | 3.33e-03 |
| GO:BP | GO:0003401 | axis elongation | 21 | 24 | 3.33e-03 |
| GO:BP | GO:1905332 | positive regulation of morphogenesis of an epithelium | 21 | 24 | 3.33e-03 |
| GO:BP | GO:0033036 | macromolecule localization | 1257 | 2309 | 3.34e-03 |
| GO:BP | GO:0019229 | regulation of vasoconstriction | 33 | 42 | 3.70e-03 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | 497 | 874 | 3.70e-03 |
| GO:BP | GO:0010927 | cellular component assembly involved in morphogenesis | 73 | 107 | 3.78e-03 |
| GO:BP | GO:0010586 | miRNA metabolic process | 61 | 87 | 3.79e-03 |
| GO:BP | GO:0001508 | action potential | 70 | 102 | 3.81e-03 |
| GO:BP | GO:0120162 | positive regulation of cold-induced thermogenesis | 50 | 69 | 3.81e-03 |
| GO:BP | GO:0099643 | signal release from synapse | 70 | 102 | 3.81e-03 |
| GO:BP | GO:0007269 | neurotransmitter secretion | 70 | 102 | 3.81e-03 |
| GO:BP | GO:0060021 | roof of mouth development | 50 | 69 | 3.81e-03 |
| GO:BP | GO:0043534 | blood vessel endothelial cell migration | 64 | 92 | 3.81e-03 |
| GO:BP | GO:0021536 | diencephalon development | 31 | 39 | 3.87e-03 |
| GO:BP | GO:0003006 | developmental process involved in reproduction | 334 | 573 | 3.88e-03 |
| GO:BP | GO:0035249 | synaptic transmission, glutamatergic | 45 | 61 | 3.92e-03 |
| GO:BP | GO:0001656 | metanephros development | 45 | 61 | 3.92e-03 |
| GO:BP | GO:1903532 | positive regulation of secretion by cell | 123 | 193 | 3.92e-03 |
| GO:BP | GO:0048662 | negative regulation of smooth muscle cell proliferation | 29 | 36 | 3.99e-03 |
| GO:BP | GO:0071869 | response to catecholamine | 29 | 36 | 3.99e-03 |
| GO:BP | GO:0071867 | response to monoamine | 29 | 36 | 3.99e-03 |
| GO:BP | GO:0097306 | cellular response to alcohol | 53 | 74 | 4.02e-03 |
| GO:BP | GO:0002792 | negative regulation of peptide secretion | 27 | 33 | 4.05e-03 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | 38 | 50 | 4.22e-03 |
| GO:BP | GO:0010660 | regulation of muscle cell apoptotic process | 38 | 50 | 4.22e-03 |
| GO:BP | GO:0048008 | platelet-derived growth factor receptor signaling pathway | 38 | 50 | 4.22e-03 |
| GO:BP | GO:0010977 | negative regulation of neuron projection development | 74 | 109 | 4.24e-03 |
| GO:BP | GO:0051250 | negative regulation of lymphocyte activation | 59 | 84 | 4.31e-03 |
| GO:BP | GO:0051048 | negative regulation of secretion | 71 | 104 | 4.32e-03 |
| GO:BP | GO:0008543 | fibroblast growth factor receptor signaling pathway | 43 | 58 | 4.39e-03 |
| GO:BP | GO:0002028 | regulation of sodium ion transport | 43 | 58 | 4.39e-03 |
| GO:BP | GO:0055082 | intracellular chemical homeostasis | 286 | 486 | 4.44e-03 |
| GO:BP | GO:1902547 | regulation of cellular response to vascular endothelial growth factor stimulus | 18 | 20 | 4.46e-03 |
| GO:BP | GO:2000116 | regulation of cysteine-type endopeptidase activity | 81 | 121 | 4.50e-03 |
| GO:BP | GO:0002067 | glandular epithelial cell differentiation | 36 | 47 | 4.63e-03 |
| GO:BP | GO:0086001 | cardiac muscle cell action potential | 46 | 63 | 4.88e-03 |
| GO:BP | GO:0032411 | positive regulation of transporter activity | 46 | 63 | 4.88e-03 |
| GO:BP | GO:0036302 | atrioventricular canal development | 12 | 12 | 4.89e-03 |
| GO:BP | GO:0032332 | positive regulation of chondrocyte differentiation | 12 | 12 | 4.89e-03 |
| GO:BP | GO:0099505 | regulation of presynaptic membrane potential | 12 | 12 | 4.89e-03 |
| GO:BP | GO:0048871 | multicellular organismal-level homeostasis | 313 | 536 | 4.89e-03 |
| GO:BP | GO:0008360 | regulation of cell shape | 72 | 106 | 4.89e-03 |
| GO:BP | GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation | 12 | 12 | 4.89e-03 |
| GO:BP | GO:0007405 | neuroblast proliferation | 41 | 55 | 4.89e-03 |
| GO:BP | GO:0045651 | positive regulation of macrophage differentiation | 12 | 12 | 4.89e-03 |
| GO:BP | GO:0010657 | muscle cell apoptotic process | 41 | 55 | 4.89e-03 |
| GO:BP | GO:0038066 | p38MAPK cascade | 34 | 44 | 4.99e-03 |
| GO:BP | GO:0002042 | cell migration involved in sprouting angiogenesis | 34 | 44 | 4.99e-03 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | 34 | 44 | 4.99e-03 |
| GO:BP | GO:0034103 | regulation of tissue remodeling | 34 | 44 | 4.99e-03 |
| GO:BP | GO:2000177 | regulation of neural precursor cell proliferation | 49 | 68 | 5.20e-03 |
| GO:BP | GO:0030162 | regulation of proteolysis | 247 | 416 | 5.29e-03 |
| GO:BP | GO:0032331 | negative regulation of chondrocyte differentiation | 15 | 16 | 5.36e-03 |
| GO:BP | GO:0001709 | cell fate determination | 20 | 23 | 5.36e-03 |
| GO:BP | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 20 | 23 | 5.36e-03 |
| GO:BP | GO:0050919 | negative chemotaxis | 32 | 41 | 5.36e-03 |
| GO:BP | GO:0070168 | negative regulation of biomineral tissue development | 15 | 16 | 5.36e-03 |
| GO:BP | GO:0061383 | trabecula morphogenesis | 32 | 41 | 5.36e-03 |
| GO:BP | GO:0031128 | developmental induction | 20 | 23 | 5.36e-03 |
| GO:BP | GO:0014888 | striated muscle adaptation | 32 | 41 | 5.36e-03 |
| GO:BP | GO:0060037 | pharyngeal system development | 20 | 23 | 5.36e-03 |
| GO:BP | GO:0045669 | positive regulation of osteoblast differentiation | 39 | 52 | 5.42e-03 |
| GO:BP | GO:0021675 | nerve development | 44 | 60 | 5.42e-03 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | 751 | 1354 | 5.54e-03 |
| GO:BP | GO:0030282 | bone mineralization | 55 | 78 | 5.62e-03 |
| GO:BP | GO:0051480 | regulation of cytosolic calcium ion concentration | 30 | 38 | 5.72e-03 |
| GO:BP | GO:0042752 | regulation of circadian rhythm | 61 | 88 | 5.78e-03 |
| GO:BP | GO:0030099 | myeloid cell differentiation | 178 | 292 | 5.78e-03 |
| GO:BP | GO:0060291 | long-term synaptic potentiation | 47 | 65 | 5.89e-03 |
| GO:BP | GO:0003209 | cardiac atrium morphogenesis | 22 | 26 | 5.90e-03 |
| GO:BP | GO:0086064 | cell communication by electrical coupling involved in cardiac conduction | 22 | 26 | 5.90e-03 |
| GO:BP | GO:0046651 | lymphocyte proliferation | 98 | 151 | 5.93e-03 |
| GO:BP | GO:0086091 | regulation of heart rate by cardiac conduction | 28 | 35 | 5.97e-03 |
| GO:BP | GO:0019933 | cAMP-mediated signaling | 28 | 35 | 5.97e-03 |
| GO:BP | GO:0090278 | negative regulation of peptide hormone secretion | 26 | 32 | 6.11e-03 |
| GO:BP | GO:0010656 | negative regulation of muscle cell apoptotic process | 26 | 32 | 6.11e-03 |
| GO:BP | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | 24 | 29 | 6.11e-03 |
| GO:BP | GO:0010837 | regulation of keratinocyte proliferation | 26 | 32 | 6.11e-03 |
| GO:BP | GO:0021954 | central nervous system neuron development | 42 | 57 | 6.11e-03 |
| GO:BP | GO:0071604 | transforming growth factor beta production | 26 | 32 | 6.11e-03 |
| GO:BP | GO:0060041 | retina development in camera-type eye | 71 | 105 | 6.30e-03 |
| GO:BP | GO:0043068 | positive regulation of programmed cell death | 231 | 388 | 6.31e-03 |
| GO:BP | GO:0045859 | regulation of protein kinase activity | 200 | 332 | 6.36e-03 |
| GO:BP | GO:0030856 | regulation of epithelial cell differentiation | 68 | 100 | 6.44e-03 |
| GO:BP | GO:0035725 | sodium ion transmembrane transport | 65 | 95 | 6.55e-03 |
| GO:BP | GO:0016311 | dephosphorylation | 144 | 232 | 6.55e-03 |
| GO:BP | GO:0010811 | positive regulation of cell-substrate adhesion | 65 | 95 | 6.55e-03 |
| GO:BP | GO:0050866 | negative regulation of cell activation | 78 | 117 | 6.59e-03 |
| GO:BP | GO:0035019 | somatic stem cell population maintenance | 35 | 46 | 6.59e-03 |
| GO:BP | GO:0006950 | response to stress | 1373 | 2540 | 6.68e-03 |
| GO:BP | GO:0034109 | homotypic cell-cell adhesion | 48 | 67 | 7.09e-03 |
| GO:BP | GO:0001892 | embryonic placenta development | 48 | 67 | 7.09e-03 |
| GO:BP | GO:0030217 | T cell differentiation | 116 | 183 | 7.20e-03 |
| GO:BP | GO:0045665 | negative regulation of neuron differentiation | 33 | 43 | 7.26e-03 |
| GO:BP | GO:0032944 | regulation of mononuclear cell proliferation | 79 | 119 | 7.35e-03 |
| GO:BP | GO:0062009 | secondary palate development | 17 | 19 | 7.35e-03 |
| GO:BP | GO:0055013 | cardiac muscle cell development | 51 | 72 | 7.37e-03 |
| GO:BP | GO:0045995 | regulation of embryonic development | 51 | 72 | 7.37e-03 |
| GO:BP | GO:0002695 | negative regulation of leukocyte activation | 66 | 97 | 7.45e-03 |
| GO:BP | GO:0032943 | mononuclear cell proliferation | 101 | 157 | 7.54e-03 |
| GO:BP | GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 43 | 59 | 7.54e-03 |
| GO:BP | GO:0046849 | bone remodeling | 43 | 59 | 7.54e-03 |
| GO:BP | GO:0045621 | positive regulation of lymphocyte differentiation | 57 | 82 | 7.63e-03 |
| GO:BP | GO:0010633 | negative regulation of epithelial cell migration | 38 | 51 | 7.67e-03 |
| GO:BP | GO:0045936 | negative regulation of phosphate metabolic process | 175 | 288 | 7.70e-03 |
| GO:BP | GO:0060326 | cell chemotaxis | 98 | 152 | 8.05e-03 |
| GO:BP | GO:0032101 | regulation of response to external stimulus | 375 | 654 | 8.47e-03 |
| GO:BP | GO:0062013 | positive regulation of small molecule metabolic process | 67 | 99 | 8.47e-03 |
| GO:BP | GO:0050670 | regulation of lymphocyte proliferation | 77 | 116 | 8.52e-03 |
| GO:BP | GO:0044843 | cell cycle G1/S phase transition | 127 | 203 | 8.58e-03 |
| GO:BP | GO:0021700 | developmental maturation | 127 | 203 | 8.58e-03 |
| GO:BP | GO:0071300 | cellular response to retinoic acid | 36 | 48 | 8.60e-03 |
| GO:BP | GO:0002021 | response to dietary excess | 19 | 22 | 8.64e-03 |
| GO:BP | GO:0097150 | neuronal stem cell population maintenance | 19 | 22 | 8.64e-03 |
| GO:BP | GO:0031623 | receptor internalization | 61 | 89 | 8.77e-03 |
| GO:BP | GO:0045637 | regulation of myeloid cell differentiation | 88 | 135 | 8.85e-03 |
| GO:BP | GO:0070661 | leukocyte proliferation | 111 | 175 | 8.86e-03 |
| GO:BP | GO:0043114 | regulation of vascular permeability | 27 | 34 | 8.99e-03 |
| GO:BP | GO:0003230 | cardiac atrium development | 27 | 34 | 8.99e-03 |
| GO:BP | GO:0060571 | morphogenesis of an epithelial fold | 14 | 15 | 9.15e-03 |
| GO:BP | GO:0014047 | glutamate secretion | 14 | 15 | 9.15e-03 |
| GO:BP | GO:0071636 | positive regulation of transforming growth factor beta production | 14 | 15 | 9.15e-03 |
| GO:BP | GO:0055012 | ventricular cardiac muscle cell differentiation | 14 | 15 | 9.15e-03 |
| GO:BP | GO:0035567 | non-canonical Wnt signaling pathway | 44 | 61 | 9.19e-03 |
| GO:BP | GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels | 44 | 61 | 9.19e-03 |
| GO:BP | GO:0030857 | negative regulation of epithelial cell differentiation | 25 | 31 | 9.28e-03 |
| GO:BP | GO:1900744 | regulation of p38MAPK cascade | 25 | 31 | 9.28e-03 |
| GO:BP | GO:0070663 | regulation of leukocyte proliferation | 85 | 130 | 9.28e-03 |
| GO:BP | GO:0090049 | regulation of cell migration involved in sprouting angiogenesis | 25 | 31 | 9.28e-03 |
| GO:BP | GO:1903351 | cellular response to dopamine | 25 | 31 | 9.28e-03 |
| GO:BP | GO:0060391 | positive regulation of SMAD protein signal transduction | 25 | 31 | 9.28e-03 |
| GO:BP | GO:0002274 | myeloid leukocyte activation | 78 | 118 | 9.29e-03 |
| GO:BP | GO:0009913 | epidermal cell differentiation | 78 | 118 | 9.29e-03 |
| GO:BP | GO:0048483 | autonomic nervous system development | 23 | 28 | 9.40e-03 |
| GO:BP | GO:0048841 | regulation of axon extension involved in axon guidance | 23 | 28 | 9.40e-03 |
| GO:BP | GO:0010563 | negative regulation of phosphorus metabolic process | 175 | 289 | 9.41e-03 |
| GO:BP | GO:0045639 | positive regulation of myeloid cell differentiation | 47 | 66 | 9.59e-03 |
| GO:BP | GO:0022408 | negative regulation of cell-cell adhesion | 75 | 113 | 9.72e-03 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | 196 | 327 | 9.73e-03 |
| GO:BP | GO:0051928 | positive regulation of calcium ion transport | 50 | 71 | 9.88e-03 |
| GO:BP | GO:1903038 | negative regulation of leukocyte cell-cell adhesion | 50 | 71 | 9.88e-03 |
| GO:BP | GO:0001819 | positive regulation of cytokine production | 157 | 257 | 9.96e-03 |
| GO:BP | GO:0007229 | integrin-mediated signaling pathway | 59 | 86 | 1.00e-02 |
| GO:BP | GO:0071887 | leukocyte apoptotic process | 53 | 76 | 1.00e-02 |
| GO:BP | GO:0048608 | reproductive structure development | 126 | 202 | 1.03e-02 |
| GO:BP | GO:0045123 | cellular extravasation | 32 | 42 | 1.04e-02 |
| GO:BP | GO:0006873 | intracellular monoatomic ion homeostasis | 214 | 360 | 1.05e-02 |
| GO:BP | GO:0045862 | positive regulation of proteolysis | 150 | 245 | 1.12e-02 |
| GO:BP | GO:0042098 | T cell proliferation | 73 | 110 | 1.13e-02 |
| GO:BP | GO:0030177 | positive regulation of Wnt signaling pathway | 73 | 110 | 1.13e-02 |
| GO:BP | GO:0043502 | regulation of muscle adaptation | 48 | 68 | 1.14e-02 |
| GO:BP | GO:0055002 | striated muscle cell development | 48 | 68 | 1.14e-02 |
| GO:BP | GO:0030003 | intracellular monoatomic cation homeostasis | 211 | 355 | 1.14e-02 |
| GO:BP | GO:0050922 | negative regulation of chemotaxis | 30 | 39 | 1.15e-02 |
| GO:BP | GO:0003014 | renal system process | 51 | 73 | 1.16e-02 |
| GO:BP | GO:0034763 | negative regulation of transmembrane transport | 57 | 83 | 1.16e-02 |
| GO:BP | GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 57 | 83 | 1.16e-02 |
| GO:BP | GO:0010976 | positive regulation of neuron projection development | 84 | 129 | 1.17e-02 |
| GO:BP | GO:0008217 | regulation of blood pressure | 70 | 105 | 1.17e-02 |
| GO:BP | GO:0042310 | vasoconstriction | 40 | 55 | 1.18e-02 |
| GO:BP | GO:0038094 | Fc-gamma receptor signaling pathway | 16 | 18 | 1.20e-02 |
| GO:BP | GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 16 | 18 | 1.20e-02 |
| GO:BP | GO:1903319 | positive regulation of protein maturation | 16 | 18 | 1.20e-02 |
| GO:BP | GO:0055093 | response to hyperoxia | 16 | 18 | 1.20e-02 |
| GO:BP | GO:0045649 | regulation of macrophage differentiation | 16 | 18 | 1.20e-02 |
| GO:BP | GO:0003228 | atrial cardiac muscle tissue development | 16 | 18 | 1.20e-02 |
| GO:BP | GO:1900746 | regulation of vascular endothelial growth factor signaling pathway | 16 | 18 | 1.20e-02 |
| GO:BP | GO:0002763 | positive regulation of myeloid leukocyte differentiation | 28 | 36 | 1.24e-02 |
| GO:BP | GO:0060443 | mammary gland morphogenesis | 28 | 36 | 1.24e-02 |
| GO:BP | GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 100 | 157 | 1.24e-02 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | 242 | 412 | 1.25e-02 |
| GO:BP | GO:0048675 | axon extension | 64 | 95 | 1.25e-02 |
| GO:BP | GO:0071214 | cellular response to abiotic stimulus | 153 | 251 | 1.28e-02 |
| GO:BP | GO:0104004 | cellular response to environmental stimulus | 153 | 251 | 1.28e-02 |
| GO:BP | GO:0008366 | axon ensheathment | 78 | 119 | 1.30e-02 |
| GO:BP | GO:0007272 | ensheathment of neurons | 78 | 119 | 1.30e-02 |
| GO:BP | GO:0048640 | negative regulation of developmental growth | 58 | 85 | 1.31e-02 |
| GO:BP | GO:0032231 | regulation of actin filament bundle assembly | 58 | 85 | 1.31e-02 |
| GO:BP | GO:0060491 | regulation of cell projection assembly | 101 | 159 | 1.32e-02 |
| GO:BP | GO:0022414 | reproductive process | 491 | 874 | 1.36e-02 |
| GO:BP | GO:0021983 | pituitary gland development | 18 | 21 | 1.37e-02 |
| GO:BP | GO:0060384 | innervation | 18 | 21 | 1.37e-02 |
| GO:BP | GO:0031324 | negative regulation of cellular metabolic process | 1051 | 1934 | 1.37e-02 |
| GO:BP | GO:0061458 | reproductive system development | 127 | 205 | 1.38e-02 |
| GO:BP | GO:0043412 | macromolecule modification | 1341 | 2489 | 1.39e-02 |
| GO:BP | GO:0001937 | negative regulation of endothelial cell proliferation | 24 | 30 | 1.39e-02 |
| GO:BP | GO:0046676 | negative regulation of insulin secretion | 24 | 30 | 1.39e-02 |
| GO:BP | GO:0048546 | digestive tract morphogenesis | 24 | 30 | 1.39e-02 |
| GO:BP | GO:0048512 | circadian behavior | 24 | 30 | 1.39e-02 |
| GO:BP | GO:0007616 | long-term memory | 24 | 30 | 1.39e-02 |
| GO:BP | GO:0046850 | regulation of bone remodeling | 24 | 30 | 1.39e-02 |
| GO:BP | GO:0050817 | coagulation | 94 | 147 | 1.40e-02 |
| GO:BP | GO:0008361 | regulation of cell size | 94 | 147 | 1.40e-02 |
| GO:BP | GO:1990845 | adaptive thermogenesis | 79 | 121 | 1.41e-02 |
| GO:BP | GO:0071260 | cellular response to mechanical stimulus | 41 | 57 | 1.42e-02 |
| GO:BP | GO:0032147 | activation of protein kinase activity | 41 | 57 | 1.42e-02 |
| GO:BP | GO:0051899 | membrane depolarization | 41 | 57 | 1.42e-02 |
| GO:BP | GO:0014898 | cardiac muscle hypertrophy in response to stress | 20 | 24 | 1.42e-02 |
| GO:BP | GO:0003299 | muscle hypertrophy in response to stress | 20 | 24 | 1.42e-02 |
| GO:BP | GO:1990573 | potassium ion import across plasma membrane | 22 | 27 | 1.42e-02 |
| GO:BP | GO:0010464 | regulation of mesenchymal cell proliferation | 22 | 27 | 1.42e-02 |
| GO:BP | GO:0045124 | regulation of bone resorption | 20 | 24 | 1.42e-02 |
| GO:BP | GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 20 | 24 | 1.42e-02 |
| GO:BP | GO:0031279 | regulation of cyclase activity | 22 | 27 | 1.42e-02 |
| GO:BP | GO:0014887 | cardiac muscle adaptation | 20 | 24 | 1.42e-02 |
| GO:BP | GO:0043065 | positive regulation of apoptotic process | 224 | 380 | 1.42e-02 |
| GO:BP | GO:0045926 | negative regulation of growth | 115 | 184 | 1.44e-02 |
| GO:BP | GO:0034446 | substrate adhesion-dependent cell spreading | 59 | 87 | 1.46e-02 |
| GO:BP | GO:0030168 | platelet activation | 59 | 87 | 1.46e-02 |
| GO:BP | GO:0030902 | hindbrain development | 69 | 104 | 1.47e-02 |
| GO:BP | GO:0045582 | positive regulation of T cell differentiation | 50 | 72 | 1.52e-02 |
| GO:BP | GO:0021533 | cell differentiation in hindbrain | 13 | 14 | 1.53e-02 |
| GO:BP | GO:0043217 | myelin maintenance | 13 | 14 | 1.53e-02 |
| GO:BP | GO:0010002 | cardioblast differentiation | 13 | 14 | 1.53e-02 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | 1137 | 2100 | 1.54e-02 |
| GO:BP | GO:1902285 | semaphorin-plexin signaling pathway involved in neuron projection guidance | 10 | 10 | 1.54e-02 |
| GO:BP | GO:0072497 | mesenchymal stem cell differentiation | 10 | 10 | 1.54e-02 |
| GO:BP | GO:0045906 | negative regulation of vasoconstriction | 10 | 10 | 1.54e-02 |
| GO:BP | GO:0022410 | circadian sleep/wake cycle process | 10 | 10 | 1.54e-02 |
| GO:BP | GO:0099149 | regulation of postsynaptic neurotransmitter receptor internalization | 10 | 10 | 1.54e-02 |
| GO:BP | GO:1902287 | semaphorin-plexin signaling pathway involved in axon guidance | 10 | 10 | 1.54e-02 |
| GO:BP | GO:0030431 | sleep | 10 | 10 | 1.54e-02 |
| GO:BP | GO:0043549 | regulation of kinase activity | 211 | 357 | 1.59e-02 |
| GO:BP | GO:1903531 | negative regulation of secretion by cell | 63 | 94 | 1.59e-02 |
| GO:BP | GO:0007596 | blood coagulation | 92 | 144 | 1.59e-02 |
| GO:BP | GO:0050918 | positive chemotaxis | 29 | 38 | 1.62e-02 |
| GO:BP | GO:0002066 | columnar/cuboidal epithelial cell development | 29 | 38 | 1.62e-02 |
| GO:BP | GO:0014074 | response to purine-containing compound | 70 | 106 | 1.62e-02 |
| GO:BP | GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | 29 | 38 | 1.62e-02 |
| GO:BP | GO:0045103 | intermediate filament-based process | 29 | 38 | 1.62e-02 |
| GO:BP | GO:0001706 | endoderm formation | 34 | 46 | 1.67e-02 |
| GO:BP | GO:0033043 | regulation of organelle organization | 532 | 953 | 1.68e-02 |
| GO:BP | GO:0030278 | regulation of ossification | 54 | 79 | 1.72e-02 |
| GO:BP | GO:0010038 | response to metal ion | 151 | 249 | 1.76e-02 |
| GO:BP | GO:0051347 | positive regulation of transferase activity | 156 | 258 | 1.76e-02 |
| GO:BP | GO:0007605 | sensory perception of sound | 64 | 96 | 1.77e-02 |
| GO:BP | GO:0008038 | neuron recognition | 27 | 35 | 1.78e-02 |
| GO:BP | GO:0001933 | negative regulation of protein phosphorylation | 137 | 224 | 1.78e-02 |
| GO:BP | GO:0042593 | glucose homeostasis | 106 | 169 | 1.80e-02 |
| GO:BP | GO:0051223 | regulation of protein transport | 193 | 325 | 1.81e-02 |
| GO:BP | GO:0042733 | embryonic digit morphogenesis | 37 | 51 | 1.82e-02 |
| GO:BP | GO:0007599 | hemostasis | 94 | 148 | 1.84e-02 |
| GO:BP | GO:0009880 | embryonic pattern specification | 32 | 43 | 1.89e-02 |
| GO:BP | GO:0042129 | regulation of T cell proliferation | 58 | 86 | 1.91e-02 |
| GO:BP | GO:0019725 | cellular homeostasis | 323 | 564 | 1.91e-02 |
| GO:BP | GO:0098884 | postsynaptic neurotransmitter receptor internalization | 15 | 17 | 1.92e-02 |
| GO:BP | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 15 | 17 | 1.92e-02 |
| GO:BP | GO:0051590 | positive regulation of neurotransmitter transport | 15 | 17 | 1.92e-02 |
| GO:BP | GO:0010954 | positive regulation of protein processing | 15 | 17 | 1.92e-02 |
| GO:BP | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | 15 | 17 | 1.92e-02 |
| GO:BP | GO:0007622 | rhythmic behavior | 25 | 32 | 1.92e-02 |
| GO:BP | GO:0140239 | postsynaptic endocytosis | 15 | 17 | 1.92e-02 |
| GO:BP | GO:0048169 | regulation of long-term neuronal synaptic plasticity | 15 | 17 | 1.92e-02 |
| GO:BP | GO:1903350 | response to dopamine | 25 | 32 | 1.92e-02 |
| GO:BP | GO:0060711 | labyrinthine layer development | 25 | 32 | 1.92e-02 |
| GO:BP | GO:0007612 | learning | 72 | 110 | 1.95e-02 |
| GO:BP | GO:0030879 | mammary gland development | 65 | 98 | 1.95e-02 |
| GO:BP | GO:0001701 | in utero embryonic development | 196 | 331 | 1.98e-02 |
| GO:BP | GO:0110053 | regulation of actin filament organization | 130 | 212 | 1.98e-02 |
| GO:BP | GO:0030239 | myofibril assembly | 46 | 66 | 2.00e-02 |
| GO:BP | GO:0106027 | neuron projection organization | 49 | 71 | 2.00e-02 |
| GO:BP | GO:0035710 | CD4-positive, alpha-beta T cell activation | 46 | 66 | 2.00e-02 |
| GO:BP | GO:0042552 | myelination | 76 | 117 | 2.01e-02 |
| GO:BP | GO:0061384 | heart trabecula morphogenesis | 23 | 29 | 2.04e-02 |
| GO:BP | GO:0042326 | negative regulation of phosphorylation | 145 | 239 | 2.04e-02 |
| GO:BP | GO:0097106 | postsynaptic density organization | 23 | 29 | 2.04e-02 |
| GO:BP | GO:0042491 | inner ear auditory receptor cell differentiation | 23 | 29 | 2.04e-02 |
| GO:BP | GO:0086019 | cell-cell signaling involved in cardiac conduction | 23 | 29 | 2.04e-02 |
| GO:BP | GO:0031102 | neuron projection regeneration | 35 | 48 | 2.05e-02 |
| GO:BP | GO:0030500 | regulation of bone mineralization | 35 | 48 | 2.05e-02 |
| GO:BP | GO:0048286 | lung alveolus development | 30 | 40 | 2.09e-02 |
| GO:BP | GO:1902905 | positive regulation of supramolecular fiber organization | 88 | 138 | 2.09e-02 |
| GO:BP | GO:0031281 | positive regulation of cyclase activity | 17 | 20 | 2.11e-02 |
| GO:BP | GO:2000114 | regulation of establishment of cell polarity | 17 | 20 | 2.11e-02 |
| GO:BP | GO:0048710 | regulation of astrocyte differentiation | 17 | 20 | 2.11e-02 |
| GO:BP | GO:0048730 | epidermis morphogenesis | 17 | 20 | 2.11e-02 |
| GO:BP | GO:0043588 | skin development | 109 | 175 | 2.12e-02 |
| GO:BP | GO:0048806 | genitalia development | 21 | 26 | 2.13e-02 |
| GO:BP | GO:1903055 | positive regulation of extracellular matrix organization | 21 | 26 | 2.13e-02 |
| GO:BP | GO:0007212 | dopamine receptor signaling pathway | 21 | 26 | 2.13e-02 |
| GO:BP | GO:1902656 | calcium ion import into cytosol | 21 | 26 | 2.13e-02 |
| GO:BP | GO:0010765 | positive regulation of sodium ion transport | 19 | 23 | 2.15e-02 |
| GO:BP | GO:0010827 | regulation of glucose transmembrane transport | 38 | 53 | 2.15e-02 |
| GO:BP | GO:0003416 | endochondral bone growth | 19 | 23 | 2.15e-02 |
| GO:BP | GO:0072012 | glomerulus vasculature development | 19 | 23 | 2.15e-02 |
| GO:BP | GO:1904752 | regulation of vascular associated smooth muscle cell migration | 19 | 23 | 2.15e-02 |
| GO:BP | GO:0043367 | CD4-positive, alpha-beta T cell differentiation | 38 | 53 | 2.15e-02 |
| GO:BP | GO:0045834 | positive regulation of lipid metabolic process | 56 | 83 | 2.15e-02 |
| GO:BP | GO:0045761 | regulation of adenylate cyclase activity | 19 | 23 | 2.15e-02 |
| GO:BP | GO:0019216 | regulation of lipid metabolic process | 132 | 216 | 2.15e-02 |
| GO:BP | GO:0010469 | regulation of signaling receptor activity | 41 | 58 | 2.24e-02 |
| GO:BP | GO:0048706 | embryonic skeletal system development | 50 | 73 | 2.26e-02 |
| GO:BP | GO:0048145 | regulation of fibroblast proliferation | 50 | 73 | 2.26e-02 |
| GO:BP | GO:0097581 | lamellipodium organization | 50 | 73 | 2.26e-02 |
| GO:BP | GO:0033500 | carbohydrate homeostasis | 106 | 170 | 2.27e-02 |
| GO:BP | GO:0097061 | dendritic spine organization | 44 | 63 | 2.27e-02 |
| GO:BP | GO:1903115 | regulation of actin filament-based movement | 28 | 37 | 2.29e-02 |
| GO:BP | GO:0045104 | intermediate filament cytoskeleton organization | 28 | 37 | 2.29e-02 |
| GO:BP | GO:0045747 | positive regulation of Notch signaling pathway | 28 | 37 | 2.29e-02 |
| GO:BP | GO:0010658 | striated muscle cell apoptotic process | 28 | 37 | 2.29e-02 |
| GO:BP | GO:0001818 | negative regulation of cytokine production | 102 | 163 | 2.30e-02 |
| GO:BP | GO:0010761 | fibroblast migration | 36 | 50 | 2.48e-02 |
| GO:BP | GO:0048814 | regulation of dendrite morphogenesis | 36 | 50 | 2.48e-02 |
| GO:BP | GO:0042490 | mechanoreceptor differentiation | 36 | 50 | 2.48e-02 |
| GO:BP | GO:0062012 | regulation of small molecule metabolic process | 140 | 231 | 2.48e-02 |
| GO:BP | GO:1901655 | cellular response to ketone | 54 | 80 | 2.50e-02 |
| GO:BP | GO:0032535 | regulation of cellular component size | 171 | 287 | 2.51e-02 |
| GO:BP | GO:0008104 | protein localization | 1081 | 2000 | 2.51e-02 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 397 | 704 | 2.51e-02 |
| GO:BP | GO:0010662 | regulation of striated muscle cell apoptotic process | 26 | 34 | 2.52e-02 |
| GO:BP | GO:0071895 | odontoblast differentiation | 12 | 13 | 2.52e-02 |
| GO:BP | GO:0010659 | cardiac muscle cell apoptotic process | 26 | 34 | 2.52e-02 |
| GO:BP | GO:0048665 | neuron fate specification | 12 | 13 | 2.52e-02 |
| GO:BP | GO:0099084 | postsynaptic specialization organization | 26 | 34 | 2.52e-02 |
| GO:BP | GO:0046579 | positive regulation of Ras protein signal transduction | 12 | 13 | 2.52e-02 |
| GO:BP | GO:1900153 | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay | 12 | 13 | 2.52e-02 |
| GO:BP | GO:0060841 | venous blood vessel development | 12 | 13 | 2.52e-02 |
| GO:BP | GO:0000003 | reproduction | 492 | 882 | 2.52e-02 |
| GO:BP | GO:0030033 | microvillus assembly | 12 | 13 | 2.52e-02 |
| GO:BP | GO:0035315 | hair cell differentiation | 26 | 34 | 2.52e-02 |
| GO:BP | GO:0009954 | proximal/distal pattern formation | 12 | 13 | 2.52e-02 |
| GO:BP | GO:0001956 | positive regulation of neurotransmitter secretion | 12 | 13 | 2.52e-02 |
| GO:BP | GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 68 | 104 | 2.54e-02 |
| GO:BP | GO:0070509 | calcium ion import | 39 | 55 | 2.54e-02 |
| GO:BP | GO:0003073 | regulation of systemic arterial blood pressure | 39 | 55 | 2.54e-02 |
| GO:BP | GO:0001954 | positive regulation of cell-matrix adhesion | 31 | 42 | 2.58e-02 |
| GO:BP | GO:0048146 | positive regulation of fibroblast proliferation | 31 | 42 | 2.58e-02 |
| GO:BP | GO:0051966 | regulation of synaptic transmission, glutamatergic | 31 | 42 | 2.58e-02 |
| GO:BP | GO:0001938 | positive regulation of endothelial cell proliferation | 48 | 70 | 2.58e-02 |
| GO:BP | GO:0048661 | positive regulation of smooth muscle cell proliferation | 42 | 60 | 2.59e-02 |
| GO:BP | GO:0035418 | protein localization to synapse | 42 | 60 | 2.59e-02 |
| GO:BP | GO:0030316 | osteoclast differentiation | 45 | 65 | 2.59e-02 |
| GO:BP | GO:0001942 | hair follicle development | 45 | 65 | 2.59e-02 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | 1055 | 1951 | 2.60e-02 |
| GO:BP | GO:0110020 | regulation of actomyosin structure organization | 58 | 87 | 2.65e-02 |
| GO:BP | GO:0051147 | regulation of muscle cell differentiation | 76 | 118 | 2.65e-02 |
| GO:BP | GO:0050714 | positive regulation of protein secretion | 65 | 99 | 2.67e-02 |
| GO:BP | GO:0046629 | gamma-delta T cell activation | 9 | 9 | 2.68e-02 |
| GO:BP | GO:2000288 | positive regulation of myoblast proliferation | 9 | 9 | 2.68e-02 |
| GO:BP | GO:0002024 | diet induced thermogenesis | 9 | 9 | 2.68e-02 |
| GO:BP | GO:0050802 | circadian sleep/wake cycle, sleep | 9 | 9 | 2.68e-02 |
| GO:BP | GO:0010838 | positive regulation of keratinocyte proliferation | 9 | 9 | 2.68e-02 |
| GO:BP | GO:0099509 | regulation of presynaptic cytosolic calcium ion concentration | 9 | 9 | 2.68e-02 |
| GO:BP | GO:0032060 | bleb assembly | 9 | 9 | 2.68e-02 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | 540 | 973 | 2.68e-02 |
| GO:BP | GO:2000739 | regulation of mesenchymal stem cell differentiation | 9 | 9 | 2.68e-02 |
| GO:BP | GO:0048845 | venous blood vessel morphogenesis | 9 | 9 | 2.68e-02 |
| GO:BP | GO:0001768 | establishment of T cell polarity | 9 | 9 | 2.68e-02 |
| GO:BP | GO:0032906 | transforming growth factor beta2 production | 9 | 9 | 2.68e-02 |
| GO:BP | GO:0032909 | regulation of transforming growth factor beta2 production | 9 | 9 | 2.68e-02 |
| GO:BP | GO:0051643 | endoplasmic reticulum localization | 9 | 9 | 2.68e-02 |
| GO:BP | GO:0061626 | pharyngeal arch artery morphogenesis | 9 | 9 | 2.68e-02 |
| GO:BP | GO:0010665 | regulation of cardiac muscle cell apoptotic process | 24 | 31 | 2.72e-02 |
| GO:BP | GO:0060688 | regulation of morphogenesis of a branching structure | 24 | 31 | 2.72e-02 |
| GO:BP | GO:0034405 | response to fluid shear stress | 24 | 31 | 2.72e-02 |
| GO:BP | GO:0070664 | negative regulation of leukocyte proliferation | 34 | 47 | 2.74e-02 |
| GO:BP | GO:0014743 | regulation of muscle hypertrophy | 34 | 47 | 2.74e-02 |
| GO:BP | GO:0045600 | positive regulation of fat cell differentiation | 34 | 47 | 2.74e-02 |
| GO:BP | GO:1903317 | regulation of protein maturation | 34 | 47 | 2.74e-02 |
| GO:BP | GO:0007584 | response to nutrient | 73 | 113 | 2.79e-02 |
| GO:BP | GO:0061024 | membrane organization | 354 | 625 | 2.81e-02 |
| GO:BP | GO:0007179 | transforming growth factor beta receptor signaling pathway | 106 | 171 | 2.82e-02 |
| GO:BP | GO:0045619 | regulation of lymphocyte differentiation | 81 | 127 | 2.85e-02 |
| GO:BP | GO:0042311 | vasodilation | 29 | 39 | 2.86e-02 |
| GO:BP | GO:0051965 | positive regulation of synapse assembly | 29 | 39 | 2.86e-02 |
| GO:BP | GO:0035904 | aorta development | 37 | 52 | 2.87e-02 |
| GO:BP | GO:1904427 | positive regulation of calcium ion transmembrane transport | 37 | 52 | 2.87e-02 |
| GO:BP | GO:0070727 | cellular macromolecule localization | 1085 | 2010 | 2.87e-02 |
| GO:BP | GO:0003171 | atrioventricular valve development | 22 | 28 | 2.92e-02 |
| GO:BP | GO:0022405 | hair cycle process | 46 | 67 | 2.92e-02 |
| GO:BP | GO:0022404 | molting cycle process | 46 | 67 | 2.92e-02 |
| GO:BP | GO:0048713 | regulation of oligodendrocyte differentiation | 22 | 28 | 2.92e-02 |
| GO:BP | GO:0060317 | cardiac epithelial to mesenchymal transition | 22 | 28 | 2.92e-02 |
| GO:BP | GO:0044331 | cell-cell adhesion mediated by cadherin | 22 | 28 | 2.92e-02 |
| GO:BP | GO:0031503 | protein-containing complex localization | 98 | 157 | 2.93e-02 |
| GO:BP | GO:0086014 | atrial cardiac muscle cell action potential | 14 | 16 | 2.99e-02 |
| GO:BP | GO:0086026 | atrial cardiac muscle cell to AV node cell signaling | 14 | 16 | 2.99e-02 |
| GO:BP | GO:0021846 | cell proliferation in forebrain | 14 | 16 | 2.99e-02 |
| GO:BP | GO:0003128 | heart field specification | 14 | 16 | 2.99e-02 |
| GO:BP | GO:0086066 | atrial cardiac muscle cell to AV node cell communication | 14 | 16 | 2.99e-02 |
| GO:BP | GO:1900274 | regulation of phospholipase C activity | 14 | 16 | 2.99e-02 |
| GO:BP | GO:0045762 | positive regulation of adenylate cyclase activity | 14 | 16 | 2.99e-02 |
| GO:BP | GO:0019827 | stem cell population maintenance | 90 | 143 | 3.00e-02 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | 535 | 965 | 3.01e-02 |
| GO:BP | GO:1904738 | vascular associated smooth muscle cell migration | 20 | 25 | 3.09e-02 |
| GO:BP | GO:0061437 | renal system vasculature development | 20 | 25 | 3.09e-02 |
| GO:BP | GO:0007435 | salivary gland morphogenesis | 20 | 25 | 3.09e-02 |
| GO:BP | GO:0061440 | kidney vasculature development | 20 | 25 | 3.09e-02 |
| GO:BP | GO:0098703 | calcium ion import across plasma membrane | 20 | 25 | 3.09e-02 |
| GO:BP | GO:0007623 | circadian rhythm | 95 | 152 | 3.15e-02 |
| GO:BP | GO:0030038 | contractile actin filament bundle assembly | 60 | 91 | 3.17e-02 |
| GO:BP | GO:0043149 | stress fiber assembly | 60 | 91 | 3.17e-02 |
| GO:BP | GO:0038179 | neurotrophin signaling pathway | 27 | 36 | 3.17e-02 |
| GO:BP | GO:0035306 | positive regulation of dephosphorylation | 27 | 36 | 3.17e-02 |
| GO:BP | GO:0060512 | prostate gland morphogenesis | 16 | 19 | 3.17e-02 |
| GO:BP | GO:0098810 | neurotransmitter reuptake | 16 | 19 | 3.17e-02 |
| GO:BP | GO:1990806 | ligand-gated ion channel signaling pathway | 16 | 19 | 3.17e-02 |
| GO:BP | GO:0099590 | neurotransmitter receptor internalization | 16 | 19 | 3.17e-02 |
| GO:BP | GO:0060740 | prostate gland epithelium morphogenesis | 16 | 19 | 3.17e-02 |
| GO:BP | GO:1901201 | regulation of extracellular matrix assembly | 16 | 19 | 3.17e-02 |
| GO:BP | GO:0042092 | type 2 immune response | 16 | 19 | 3.17e-02 |
| GO:BP | GO:0003338 | metanephros morphogenesis | 16 | 19 | 3.17e-02 |
| GO:BP | GO:0097529 | myeloid leukocyte migration | 71 | 110 | 3.17e-02 |
| GO:BP | GO:0055075 | potassium ion homeostasis | 18 | 22 | 3.18e-02 |
| GO:BP | GO:0030279 | negative regulation of ossification | 18 | 22 | 3.18e-02 |
| GO:BP | GO:0031400 | negative regulation of protein modification process | 191 | 325 | 3.18e-02 |
| GO:BP | GO:1904705 | regulation of vascular associated smooth muscle cell proliferation | 35 | 49 | 3.24e-02 |
| GO:BP | GO:0018107 | peptidyl-threonine phosphorylation | 47 | 69 | 3.28e-02 |
| GO:BP | GO:1990778 | protein localization to cell periphery | 170 | 287 | 3.34e-02 |
| GO:BP | GO:0016239 | positive regulation of macroautophagy | 44 | 64 | 3.34e-02 |
| GO:BP | GO:0050868 | negative regulation of T cell activation | 44 | 64 | 3.34e-02 |
| GO:BP | GO:0050772 | positive regulation of axonogenesis | 44 | 64 | 3.34e-02 |
| GO:BP | GO:0140238 | presynaptic endocytosis | 41 | 59 | 3.36e-02 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | 88 | 140 | 3.41e-02 |
| GO:BP | GO:0106106 | cold-induced thermogenesis | 72 | 112 | 3.42e-02 |
| GO:BP | GO:1903034 | regulation of response to wounding | 76 | 119 | 3.45e-02 |
| GO:BP | GO:0046683 | response to organophosphorus | 61 | 93 | 3.46e-02 |
| GO:BP | GO:0010171 | body morphogenesis | 30 | 41 | 3.49e-02 |
| GO:BP | GO:0045453 | bone resorption | 30 | 41 | 3.49e-02 |
| GO:BP | GO:0007600 | sensory perception | 150 | 251 | 3.50e-02 |
| GO:BP | GO:1902692 | regulation of neuroblast proliferation | 25 | 33 | 3.51e-02 |
| GO:BP | GO:0038093 | Fc receptor signaling pathway | 25 | 33 | 3.51e-02 |
| GO:BP | GO:0018210 | peptidyl-threonine modification | 51 | 76 | 3.58e-02 |
| GO:BP | GO:0060996 | dendritic spine development | 51 | 76 | 3.58e-02 |
| GO:BP | GO:0007219 | Notch signaling pathway | 89 | 142 | 3.63e-02 |
| GO:BP | GO:0030595 | leukocyte chemotaxis | 69 | 107 | 3.65e-02 |
| GO:BP | GO:0032880 | regulation of protein localization | 388 | 691 | 3.70e-02 |
| GO:BP | GO:0001655 | urogenital system development | 33 | 46 | 3.71e-02 |
| GO:BP | GO:0010611 | regulation of cardiac muscle hypertrophy | 33 | 46 | 3.71e-02 |
| GO:BP | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 33 | 46 | 3.71e-02 |
| GO:BP | GO:0062014 | negative regulation of small molecule metabolic process | 48 | 71 | 3.71e-02 |
| GO:BP | GO:1904036 | negative regulation of epithelial cell apoptotic process | 33 | 46 | 3.71e-02 |
| GO:BP | GO:0007265 | Ras protein signal transduction | 62 | 95 | 3.78e-02 |
| GO:BP | GO:0051153 | regulation of striated muscle cell differentiation | 45 | 66 | 3.80e-02 |
| GO:BP | GO:0006887 | exocytosis | 142 | 237 | 3.83e-02 |
| GO:BP | GO:0050771 | negative regulation of axonogenesis | 36 | 51 | 3.83e-02 |
| GO:BP | GO:0043266 | regulation of potassium ion transport | 42 | 61 | 3.85e-02 |
| GO:BP | GO:0031668 | cellular response to extracellular stimulus | 132 | 219 | 3.85e-02 |
| GO:BP | GO:0033273 | response to vitamin | 42 | 61 | 3.85e-02 |
| GO:BP | GO:0002088 | lens development in camera-type eye | 39 | 56 | 3.87e-02 |
| GO:BP | GO:1904019 | epithelial cell apoptotic process | 66 | 102 | 3.87e-02 |
| GO:BP | GO:0052652 | cyclic purine nucleotide metabolic process | 23 | 30 | 3.88e-02 |
| GO:BP | GO:0014911 | positive regulation of smooth muscle cell migration | 23 | 30 | 3.88e-02 |
| GO:BP | GO:0001659 | temperature homeostasis | 82 | 130 | 3.93e-02 |
| GO:BP | GO:2001222 | regulation of neuron migration | 28 | 38 | 3.94e-02 |
| GO:BP | GO:0006940 | regulation of smooth muscle contraction | 28 | 38 | 3.94e-02 |
| GO:BP | GO:0045668 | negative regulation of osteoblast differentiation | 28 | 38 | 3.94e-02 |
| GO:BP | GO:0061005 | cell differentiation involved in kidney development | 28 | 38 | 3.94e-02 |
| GO:BP | GO:0052548 | regulation of endopeptidase activity | 95 | 153 | 3.97e-02 |
| GO:BP | GO:0050773 | regulation of dendrite development | 52 | 78 | 3.97e-02 |
| GO:BP | GO:0046942 | carboxylic acid transport | 123 | 203 | 3.98e-02 |
| GO:BP | GO:0072578 | neurotransmitter-gated ion channel clustering | 11 | 12 | 4.07e-02 |
| GO:BP | GO:0045780 | positive regulation of bone resorption | 11 | 12 | 4.07e-02 |
| GO:BP | GO:0048368 | lateral mesoderm development | 11 | 12 | 4.07e-02 |
| GO:BP | GO:0003222 | ventricular trabecula myocardium morphogenesis | 11 | 12 | 4.07e-02 |
| GO:BP | GO:0061154 | endothelial tube morphogenesis | 11 | 12 | 4.07e-02 |
| GO:BP | GO:0003207 | cardiac chamber formation | 11 | 12 | 4.07e-02 |
| GO:BP | GO:0055057 | neuroblast division | 11 | 12 | 4.07e-02 |
| GO:BP | GO:0003159 | morphogenesis of an endothelium | 11 | 12 | 4.07e-02 |
| GO:BP | GO:0030539 | male genitalia development | 11 | 12 | 4.07e-02 |
| GO:BP | GO:0031669 | cellular response to nutrient levels | 119 | 196 | 4.12e-02 |
| GO:BP | GO:0001558 | regulation of cell growth | 189 | 323 | 4.13e-02 |
| GO:BP | GO:0038127 | ERBB signaling pathway | 67 | 104 | 4.16e-02 |
| GO:BP | GO:0051651 | maintenance of location in cell | 105 | 171 | 4.16e-02 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | 587 | 1067 | 4.18e-02 |
| GO:BP | GO:0120161 | regulation of cold-induced thermogenesis | 71 | 111 | 4.18e-02 |
| GO:BP | GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 21 | 27 | 4.18e-02 |
| GO:BP | GO:0120033 | negative regulation of plasma membrane bounded cell projection assembly | 21 | 27 | 4.18e-02 |
| GO:BP | GO:0010517 | regulation of phospholipase activity | 21 | 27 | 4.18e-02 |
| GO:BP | GO:0035909 | aorta morphogenesis | 21 | 27 | 4.18e-02 |
| GO:BP | GO:0031333 | negative regulation of protein-containing complex assembly | 75 | 118 | 4.18e-02 |
| GO:BP | GO:0002294 | CD4-positive, alpha-beta T cell differentiation involved in immune response | 31 | 43 | 4.18e-02 |
| GO:BP | GO:0030514 | negative regulation of BMP signaling pathway | 31 | 43 | 4.18e-02 |
| GO:BP | GO:0042093 | T-helper cell differentiation | 31 | 43 | 4.18e-02 |
| GO:BP | GO:0070570 | regulation of neuron projection regeneration | 21 | 27 | 4.18e-02 |
| GO:BP | GO:0032945 | negative regulation of mononuclear cell proliferation | 31 | 43 | 4.18e-02 |
| GO:BP | GO:0002293 | alpha-beta T cell differentiation involved in immune response | 31 | 43 | 4.18e-02 |
| GO:BP | GO:0050672 | negative regulation of lymphocyte proliferation | 31 | 43 | 4.18e-02 |
| GO:BP | GO:0002287 | alpha-beta T cell activation involved in immune response | 31 | 43 | 4.18e-02 |
| GO:BP | GO:0150104 | transport across blood-brain barrier | 46 | 68 | 4.20e-02 |
| GO:BP | GO:0010232 | vascular transport | 46 | 68 | 4.20e-02 |
| GO:BP | GO:0060249 | anatomical structure homeostasis | 101 | 164 | 4.24e-02 |
| GO:BP | GO:0001894 | tissue homeostasis | 101 | 164 | 4.24e-02 |
| GO:BP | GO:0010629 | negative regulation of gene expression | 440 | 790 | 4.24e-02 |
| GO:BP | GO:0060113 | inner ear receptor cell differentiation | 34 | 48 | 4.32e-02 |
| GO:BP | GO:0048488 | synaptic vesicle endocytosis | 40 | 58 | 4.38e-02 |
| GO:BP | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 40 | 58 | 4.38e-02 |
| GO:BP | GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 26 | 35 | 4.38e-02 |
| GO:BP | GO:0034113 | heterotypic cell-cell adhesion | 26 | 35 | 4.38e-02 |
| GO:BP | GO:0010508 | positive regulation of autophagy | 80 | 127 | 4.43e-02 |
| GO:BP | GO:0098781 | ncRNA transcription | 76 | 120 | 4.47e-02 |
| GO:BP | GO:0040036 | regulation of fibroblast growth factor receptor signaling pathway | 19 | 24 | 4.49e-02 |
| GO:BP | GO:0033280 | response to vitamin D | 19 | 24 | 4.49e-02 |
| GO:BP | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 19 | 24 | 4.49e-02 |
| GO:BP | GO:0022011 | myelination in peripheral nervous system | 19 | 24 | 4.49e-02 |
| GO:BP | GO:0032292 | peripheral nervous system axon ensheathment | 19 | 24 | 4.49e-02 |
| GO:BP | GO:0001958 | endochondral ossification | 19 | 24 | 4.49e-02 |
| GO:BP | GO:0098868 | bone growth | 19 | 24 | 4.49e-02 |
| GO:BP | GO:0036075 | replacement ossification | 19 | 24 | 4.49e-02 |
| GO:BP | GO:0030534 | adult behavior | 57 | 87 | 4.50e-02 |
| GO:BP | GO:0042303 | molting cycle | 50 | 75 | 4.50e-02 |
| GO:BP | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 50 | 75 | 4.50e-02 |
| GO:BP | GO:0042633 | hair cycle | 50 | 75 | 4.50e-02 |
| GO:BP | GO:0097152 | mesenchymal cell apoptotic process | 8 | 8 | 4.56e-02 |
| GO:BP | GO:0045187 | regulation of circadian sleep/wake cycle, sleep | 8 | 8 | 4.56e-02 |
| GO:BP | GO:0036462 | TRAIL-activated apoptotic signaling pathway | 8 | 8 | 4.56e-02 |
| GO:BP | GO:0071389 | cellular response to mineralocorticoid stimulus | 8 | 8 | 4.56e-02 |
| GO:BP | GO:0040034 | regulation of development, heterochronic | 8 | 8 | 4.56e-02 |
| GO:BP | GO:0060982 | coronary artery morphogenesis | 8 | 8 | 4.56e-02 |
| GO:BP | GO:0048505 | regulation of timing of cell differentiation | 8 | 8 | 4.56e-02 |
| GO:BP | GO:0048715 | negative regulation of oligodendrocyte differentiation | 8 | 8 | 4.56e-02 |
| GO:BP | GO:0003190 | atrioventricular valve formation | 8 | 8 | 4.56e-02 |
| GO:BP | GO:0032674 | regulation of interleukin-5 production | 8 | 8 | 4.56e-02 |
| GO:BP | GO:0060896 | neural plate pattern specification | 8 | 8 | 4.56e-02 |
| GO:BP | GO:0032634 | interleukin-5 production | 8 | 8 | 4.56e-02 |
| GO:BP | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity | 8 | 8 | 4.56e-02 |
| GO:BP | GO:1900116 | extracellular negative regulation of signal transduction | 8 | 8 | 4.56e-02 |
| GO:BP | GO:0099624 | atrial cardiac muscle cell membrane repolarization | 8 | 8 | 4.56e-02 |
| GO:BP | GO:1900115 | extracellular regulation of signal transduction | 8 | 8 | 4.56e-02 |
| GO:BP | GO:0003149 | membranous septum morphogenesis | 8 | 8 | 4.56e-02 |
| GO:BP | GO:0003418 | growth plate cartilage chondrocyte differentiation | 8 | 8 | 4.56e-02 |
| GO:BP | GO:0018193 | peptidyl-amino acid modification | 314 | 555 | 4.56e-02 |
| GO:BP | GO:0002828 | regulation of type 2 immune response | 13 | 15 | 4.58e-02 |
| GO:BP | GO:0051546 | keratinocyte migration | 13 | 15 | 4.58e-02 |
| GO:BP | GO:1902932 | positive regulation of alcohol biosynthetic process | 13 | 15 | 4.58e-02 |
| GO:BP | GO:0072170 | metanephric tubule development | 13 | 15 | 4.58e-02 |
| GO:BP | GO:0060413 | atrial septum morphogenesis | 13 | 15 | 4.58e-02 |
| GO:BP | GO:1902683 | regulation of receptor localization to synapse | 13 | 15 | 4.58e-02 |
| GO:BP | GO:0070571 | negative regulation of neuron projection regeneration | 13 | 15 | 4.58e-02 |
| GO:BP | GO:0032891 | negative regulation of organic acid transport | 13 | 15 | 4.58e-02 |
| GO:BP | GO:0016079 | synaptic vesicle exocytosis | 47 | 70 | 4.60e-02 |
| GO:BP | GO:1900745 | positive regulation of p38MAPK cascade | 17 | 21 | 4.66e-02 |
| GO:BP | GO:2000178 | negative regulation of neural precursor cell proliferation | 17 | 21 | 4.66e-02 |
| GO:BP | GO:0031327 | negative regulation of cellular biosynthetic process | 879 | 1624 | 4.67e-02 |
| GO:BP | GO:0015849 | organic acid transport | 123 | 204 | 4.71e-02 |
| GO:BP | GO:0051495 | positive regulation of cytoskeleton organization | 90 | 145 | 4.71e-02 |
| GO:BP | GO:0098727 | maintenance of cell number | 90 | 145 | 4.71e-02 |
| GO:BP | GO:0032869 | cellular response to insulin stimulus | 99 | 161 | 4.71e-02 |
| GO:BP | GO:0032925 | regulation of activin receptor signaling pathway | 15 | 18 | 4.74e-02 |
| GO:BP | GO:0071880 | adenylate cyclase-activating adrenergic receptor signaling pathway | 15 | 18 | 4.74e-02 |
| GO:BP | GO:0031069 | hair follicle morphogenesis | 15 | 18 | 4.74e-02 |
| GO:BP | GO:0033032 | regulation of myeloid cell apoptotic process | 15 | 18 | 4.74e-02 |
| GO:BP | GO:0007187 | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 15 | 18 | 4.74e-02 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | 178 | 304 | 4.77e-02 |
| GO:BP | GO:0030501 | positive regulation of bone mineralization | 24 | 32 | 4.78e-02 |
| GO:BP | GO:0042220 | response to cocaine | 24 | 32 | 4.78e-02 |
| GO:BP | GO:0062237 | protein localization to postsynapse | 24 | 32 | 4.78e-02 |
| GO:BP | GO:0070884 | regulation of calcineurin-NFAT signaling cascade | 24 | 32 | 4.78e-02 |
| GO:BP | GO:0106056 | regulation of calcineurin-mediated signaling | 24 | 32 | 4.78e-02 |
| GO:BP | GO:1903539 | protein localization to postsynaptic membrane | 24 | 32 | 4.78e-02 |
| GO:BP | GO:0086004 | regulation of cardiac muscle cell contraction | 24 | 32 | 4.78e-02 |
| GO:BP | GO:0050709 | negative regulation of protein secretion | 32 | 45 | 4.80e-02 |
| GO:BP | GO:0002292 | T cell differentiation involved in immune response | 32 | 45 | 4.80e-02 |
| GO:BP | GO:0060071 | Wnt signaling pathway, planar cell polarity pathway | 32 | 45 | 4.80e-02 |
| GO:BP | GO:0007548 | sex differentiation | 109 | 179 | 4.80e-02 |
| GO:BP | GO:0060997 | dendritic spine morphogenesis | 32 | 45 | 4.80e-02 |
| GO:BP | GO:0046486 | glycerolipid metabolic process | 167 | 284 | 4.81e-02 |
| GO:BP | GO:0051492 | regulation of stress fiber assembly | 51 | 77 | 4.85e-02 |
| GO:BP | GO:0010950 | positive regulation of endopeptidase activity | 62 | 96 | 4.88e-02 |
| GO:BP | GO:0070527 | platelet aggregation | 35 | 50 | 4.88e-02 |
| GO:BP | GO:0051145 | smooth muscle cell differentiation | 38 | 55 | 4.88e-02 |
| GO:BP | GO:1901019 | regulation of calcium ion transmembrane transporter activity | 35 | 50 | 4.88e-02 |
| GO:BP | GO:0031016 | pancreas development | 35 | 50 | 4.88e-02 |
| GO:BP | GO:0030041 | actin filament polymerization | 78 | 124 | 4.90e-02 |
| GO:BP | GO:0046718 | symbiont entry into host cell | 66 | 103 | 4.94e-02 |
| GO:BP | GO:0050954 | sensory perception of mechanical stimulus | 70 | 110 | 4.96e-02 |
ESRnomtable %>%
filter(source=="KEGG", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in ESR neargenes") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:04510 | Focal adhesion | 128 | 169 | 4.34e-09 |
| KEGG | KEGG:05200 | Pathways in cancer | 263 | 391 | 4.34e-09 |
| KEGG | KEGG:04020 | Calcium signaling pathway | 123 | 161 | 4.34e-09 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | 121 | 162 | 3.73e-08 |
| KEGG | KEGG:04925 | Aldosterone synthesis and secretion | 64 | 75 | 3.73e-08 |
| KEGG | KEGG:04024 | cAMP signaling pathway | 111 | 147 | 5.35e-08 |
| KEGG | KEGG:04360 | Axon guidance | 114 | 155 | 3.91e-07 |
| KEGG | KEGG:04310 | Wnt signaling pathway | 98 | 133 | 3.28e-06 |
| KEGG | KEGG:04911 | Insulin secretion | 51 | 62 | 1.25e-05 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | 64 | 82 | 1.36e-05 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 114 | 162 | 1.36e-05 |
| KEGG | KEGG:04970 | Salivary secretion | 45 | 54 | 2.12e-05 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | 90 | 124 | 2.12e-05 |
| KEGG | KEGG:04022 | cGMP-PKG signaling pathway | 93 | 129 | 2.14e-05 |
| KEGG | KEGG:04520 | Adherens junction | 64 | 83 | 2.19e-05 |
| KEGG | KEGG:04724 | Glutamatergic synapse | 58 | 74 | 2.54e-05 |
| KEGG | KEGG:04927 | Cortisol synthesis and secretion | 39 | 46 | 3.73e-05 |
| KEGG | KEGG:04014 | Ras signaling pathway | 113 | 164 | 4.85e-05 |
| KEGG | KEGG:04512 | ECM-receptor interaction | 52 | 66 | 5.79e-05 |
| KEGG | KEGG:04971 | Gastric acid secretion | 42 | 51 | 6.00e-05 |
| KEGG | KEGG:04010 | MAPK signaling pathway | 152 | 231 | 6.12e-05 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | 163 | 250 | 6.12e-05 |
| KEGG | KEGG:04390 | Hippo signaling pathway | 91 | 129 | 7.77e-05 |
| KEGG | KEGG:04924 | Renin secretion | 41 | 50 | 8.12e-05 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | 76 | 105 | 9.35e-05 |
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | 52 | 67 | 9.52e-05 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | 114 | 169 | 1.36e-04 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | 58 | 77 | 1.36e-04 |
| KEGG | KEGG:04934 | Cushing syndrome | 84 | 119 | 1.36e-04 |
| KEGG | KEGG:04972 | Pancreatic secretion | 45 | 57 | 1.50e-04 |
| KEGG | KEGG:04725 | Cholinergic synapse | 61 | 82 | 1.50e-04 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | 80 | 113 | 1.66e-04 |
| KEGG | KEGG:04974 | Protein digestion and absorption | 44 | 56 | 2.20e-04 |
| KEGG | KEGG:04611 | Platelet activation | 64 | 88 | 2.84e-04 |
| KEGG | KEGG:04713 | Circadian entrainment | 51 | 68 | 4.58e-04 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | 56 | 76 | 4.58e-04 |
| KEGG | KEGG:04750 | Inflammatory mediator regulation of TRP channels | 53 | 72 | 7.33e-04 |
| KEGG | KEGG:05224 | Breast cancer | 78 | 113 | 7.33e-04 |
| KEGG | KEGG:04514 | Cell adhesion molecules | 51 | 69 | 8.01e-04 |
| KEGG | KEGG:04923 | Regulation of lipolysis in adipocytes | 33 | 41 | 8.50e-04 |
| KEGG | KEGG:04072 | Phospholipase D signaling pathway | 74 | 107 | 9.33e-04 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 56 | 78 | 1.27e-03 |
| KEGG | KEGG:04961 | Endocrine and other factor-regulated calcium reabsorption | 32 | 40 | 1.27e-03 |
| KEGG | KEGG:05032 | Morphine addiction | 41 | 54 | 1.28e-03 |
| KEGG | KEGG:05226 | Gastric cancer | 77 | 113 | 1.33e-03 |
| KEGG | KEGG:04916 | Melanogenesis | 54 | 75 | 1.37e-03 |
| KEGG | KEGG:04148 | Efferocytosis | 81 | 120 | 1.41e-03 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | 91 | 137 | 1.41e-03 |
| KEGG | KEGG:05218 | Melanoma | 42 | 56 | 1.55e-03 |
| KEGG | KEGG:04728 | Dopaminergic synapse | 67 | 97 | 1.66e-03 |
| KEGG | KEGG:04270 | Vascular smooth muscle contraction | 64 | 92 | 1.66e-03 |
| KEGG | KEGG:04726 | Serotonergic synapse | 43 | 58 | 1.91e-03 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | 69 | 101 | 2.16e-03 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | 81 | 122 | 2.82e-03 |
| KEGG | KEGG:04371 | Apelin signaling pathway | 70 | 104 | 3.70e-03 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | 65 | 96 | 4.41e-03 |
| KEGG | KEGG:05165 | Human papillomavirus infection | 154 | 252 | 4.67e-03 |
| KEGG | KEGG:04213 | Longevity regulating pathway - multiple species | 37 | 50 | 4.67e-03 |
| KEGG | KEGG:04929 | GnRH secretion | 37 | 50 | 4.67e-03 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | 102 | 160 | 4.67e-03 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | 67 | 100 | 5.25e-03 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | 61 | 90 | 5.53e-03 |
| KEGG | KEGG:04727 | GABAergic synapse | 38 | 52 | 5.68e-03 |
| KEGG | KEGG:04976 | Bile secretion | 31 | 41 | 6.23e-03 |
| KEGG | KEGG:04340 | Hedgehog signaling pathway | 36 | 49 | 6.23e-03 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | 59 | 87 | 6.23e-03 |
| KEGG | KEGG:04530 | Tight junction | 83 | 129 | 8.32e-03 |
| KEGG | KEGG:04540 | Gap junction | 49 | 71 | 8.54e-03 |
| KEGG | KEGG:04742 | Taste transduction | 17 | 20 | 9.03e-03 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | 41 | 58 | 9.57e-03 |
| KEGG | KEGG:04380 | Osteoclast differentiation | 61 | 92 | 1.11e-02 |
| KEGG | KEGG:05214 | Glioma | 45 | 65 | 1.12e-02 |
| KEGG | KEGG:04060 | Cytokine-cytokine receptor interaction | 62 | 94 | 1.21e-02 |
| KEGG | KEGG:04152 | AMPK signaling pathway | 66 | 101 | 1.25e-02 |
| KEGG | KEGG:05146 | Amoebiasis | 43 | 62 | 1.27e-02 |
| KEGG | KEGG:04931 | Insulin resistance | 60 | 91 | 1.37e-02 |
| KEGG | KEGG:05210 | Colorectal cancer | 54 | 81 | 1.50e-02 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | 90 | 144 | 1.65e-02 |
| KEGG | KEGG:04720 | Long-term potentiation | 36 | 51 | 1.65e-02 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | 52 | 78 | 1.68e-02 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | 59 | 90 | 1.68e-02 |
| KEGG | KEGG:04012 | ErbB signaling pathway | 50 | 75 | 1.96e-02 |
| KEGG | KEGG:05222 | Small cell lung cancer | 54 | 82 | 2.04e-02 |
| KEGG | KEGG:01522 | Endocrine resistance | 54 | 82 | 2.04e-02 |
| KEGG | KEGG:05031 | Amphetamine addiction | 32 | 45 | 2.11e-02 |
| KEGG | KEGG:04071 | Sphingolipid signaling pathway | 66 | 103 | 2.16e-02 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | 48 | 72 | 2.19e-02 |
| KEGG | KEGG:04973 | Carbohydrate digestion and absorption | 22 | 29 | 2.30e-02 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | 56 | 86 | 2.36e-02 |
| KEGG | KEGG:00000 | KEGG root term | 2855 | 5451 | 2.47e-02 |
| KEGG | KEGG:00051 | Fructose and mannose metabolism | 20 | 26 | 2.47e-02 |
| KEGG | KEGG:04913 | Ovarian steroidogenesis | 20 | 26 | 2.47e-02 |
| KEGG | KEGG:04730 | Long-term depression | 28 | 39 | 2.65e-02 |
| KEGG | KEGG:05213 | Endometrial cancer | 37 | 54 | 2.68e-02 |
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | 49 | 75 | 3.31e-02 |
| KEGG | KEGG:04659 | Th17 cell differentiation | 40 | 60 | 3.92e-02 |
| KEGG | KEGG:05131 | Shigellosis | 121 | 204 | 3.93e-02 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | 81 | 132 | 3.98e-02 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | 48 | 74 | 4.08e-02 |
| KEGG | KEGG:00514 | Other types of O-glycan biosynthesis | 25 | 35 | 4.08e-02 |
| KEGG | KEGG:04912 | GnRH signaling pathway | 48 | 74 | 4.08e-02 |
| KEGG | KEGG:04930 | Type II diabetes mellitus | 25 | 35 | 4.08e-02 |
| KEGG | KEGG:04061 | Viral protein interaction with cytokine and cytokine receptor | 15 | 19 | 4.25e-02 |
| KEGG | KEGG:04614 | Renin-angiotensin system | 9 | 10 | 4.35e-02 |
| KEGG | KEGG:05033 | Nicotine addiction | 9 | 10 | 4.35e-02 |
| KEGG | KEGG:00564 | Glycerophospholipid metabolism | 46 | 71 | 4.58e-02 |
| KEGG | KEGG:05030 | Cocaine addiction | 23 | 32 | 4.59e-02 |
| KEGG | KEGG:04080 | Neuroactive ligand-receptor interaction | 63 | 101 | 4.76e-02 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | 51 | 80 | 4.91e-02 |
ESRnomtable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
slice_head(n=10) %>%
mutate(log10_p=(-log(p_value, base=10))) %>%
ggplot(., aes(x=log10_p, y=reorder(term_name, log10_p)))+
geom_col(fill="#7CAE00")+
theme_bw()+
ylab("")+
xlab(paste0("-log10 p-value"))+
guides(fill="none")
LR response genes
# LR_resgenes <- gost(query = LR_NG_list$ENTREZID,
# organism = "hsapiens",
# significant = FALSE,
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = background_df$ENTREZID,
# sources=c("GO:BP","KEGG"))
# saveRDS(LR_resgenes,"data/GO_KEGG_analysis/LR_resgenes.RDS")
# LRnom <- gostplot(LR_resgenes, capped = FALSE, interactive = TRUE)
# LRnom
LRnomtable <- LR_resgenes$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
LRnomtable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in LR neargenes" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0032501 | multicellular organismal process | 3517 | 4504 | 2.85e-37 |
| GO:BP | GO:0048731 | system development | 2194 | 2719 | 1.88e-35 |
| GO:BP | GO:0007154 | cell communication | 3123 | 3983 | 2.81e-34 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 1527 | 1844 | 8.13e-34 |
| GO:BP | GO:0048856 | anatomical structure development | 3035 | 3867 | 8.13e-34 |
| GO:BP | GO:0023052 | signaling | 3073 | 3918 | 8.13e-34 |
| GO:BP | GO:0007275 | multicellular organism development | 2520 | 3170 | 1.90e-33 |
| GO:BP | GO:0032502 | developmental process | 3261 | 4179 | 1.90e-33 |
| GO:BP | GO:0007165 | signal transduction | 2834 | 3611 | 9.26e-31 |
| GO:BP | GO:0050896 | response to stimulus | 4108 | 5379 | 4.91e-29 |
| GO:BP | GO:0051716 | cellular response to stimulus | 3575 | 4640 | 6.17e-29 |
| GO:BP | GO:0007399 | nervous system development | 1449 | 1775 | 5.17e-26 |
| GO:BP | GO:0022008 | neurogenesis | 1048 | 1251 | 8.68e-26 |
| GO:BP | GO:0048869 | cellular developmental process | 2217 | 2804 | 1.25e-25 |
| GO:BP | GO:0030154 | cell differentiation | 2216 | 2803 | 1.35e-25 |
| GO:BP | GO:0048513 | animal organ development | 1616 | 2004 | 1.66e-24 |
| GO:BP | GO:0050793 | regulation of developmental process | 1384 | 1697 | 2.10e-24 |
| GO:BP | GO:0048699 | generation of neurons | 907 | 1076 | 7.45e-24 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | 1460 | 1801 | 1.06e-23 |
| GO:BP | GO:0010646 | regulation of cell communication | 1940 | 2444 | 2.20e-23 |
| GO:BP | GO:0030182 | neuron differentiation | 856 | 1014 | 7.74e-23 |
| GO:BP | GO:0023051 | regulation of signaling | 1933 | 2438 | 8.19e-23 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 1547 | 1924 | 2.85e-22 |
| GO:BP | GO:0016477 | cell migration | 848 | 1011 | 7.88e-21 |
| GO:BP | GO:0007155 | cell adhesion | 791 | 941 | 7.79e-20 |
| GO:BP | GO:0009887 | animal organ morphogenesis | 581 | 673 | 1.35e-19 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 2124 | 2717 | 1.94e-19 |
| GO:BP | GO:0009966 | regulation of signal transduction | 1713 | 2166 | 9.59e-19 |
| GO:BP | GO:0048468 | cell development | 1504 | 1886 | 1.08e-18 |
| GO:BP | GO:0048870 | cell motility | 924 | 1120 | 2.51e-18 |
| GO:BP | GO:0009888 | tissue development | 1096 | 1348 | 7.00e-18 |
| GO:BP | GO:0000902 | cell morphogenesis | 607 | 713 | 1.85e-17 |
| GO:BP | GO:0007267 | cell-cell signaling | 892 | 1082 | 1.86e-17 |
| GO:BP | GO:0003008 | system process | 935 | 1139 | 2.58e-17 |
| GO:BP | GO:0040012 | regulation of locomotion | 612 | 720 | 2.58e-17 |
| GO:BP | GO:2000145 | regulation of cell motility | 596 | 700 | 3.50e-17 |
| GO:BP | GO:0072359 | circulatory system development | 723 | 864 | 4.90e-17 |
| GO:BP | GO:0035295 | tube development | 663 | 787 | 6.44e-17 |
| GO:BP | GO:0030334 | regulation of cell migration | 570 | 668 | 7.71e-17 |
| GO:BP | GO:0051094 | positive regulation of developmental process | 760 | 913 | 8.43e-17 |
| GO:BP | GO:0031175 | neuron projection development | 628 | 743 | 1.18e-16 |
| GO:BP | GO:0040011 | locomotion | 676 | 805 | 1.28e-16 |
| GO:BP | GO:0048666 | neuron development | 701 | 838 | 1.92e-16 |
| GO:BP | GO:0035239 | tube morphogenesis | 545 | 638 | 2.70e-16 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | 505 | 588 | 5.26e-16 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | 698 | 837 | 1.02e-15 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 3005 | 3954 | 1.16e-15 |
| GO:BP | GO:0050789 | regulation of biological process | 5544 | 7516 | 1.29e-15 |
| GO:BP | GO:0030030 | cell projection organization | 961 | 1182 | 1.55e-15 |
| GO:BP | GO:0048518 | positive regulation of biological process | 3254 | 4301 | 2.05e-15 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | 784 | 951 | 2.95e-15 |
| GO:BP | GO:0048858 | cell projection morphogenesis | 432 | 498 | 3.12e-15 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | 935 | 1150 | 4.30e-15 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | 603 | 717 | 4.94e-15 |
| GO:BP | GO:0120039 | plasma membrane bounded cell projection morphogenesis | 428 | 494 | 6.88e-15 |
| GO:BP | GO:0048812 | neuron projection morphogenesis | 416 | 479 | 7.60e-15 |
| GO:BP | GO:0001568 | blood vessel development | 452 | 525 | 1.08e-14 |
| GO:BP | GO:0051093 | negative regulation of developmental process | 528 | 622 | 1.14e-14 |
| GO:BP | GO:0045595 | regulation of cell differentiation | 874 | 1073 | 1.96e-14 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | 517 | 609 | 2.32e-14 |
| GO:BP | GO:0050794 | regulation of cellular process | 5279 | 7153 | 2.55e-14 |
| GO:BP | GO:0001944 | vasculature development | 472 | 552 | 3.18e-14 |
| GO:BP | GO:0065007 | biological regulation | 5684 | 7734 | 8.19e-14 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | 845 | 1040 | 2.20e-13 |
| GO:BP | GO:0141124 | intracellular signaling cassette | 1051 | 1314 | 3.49e-13 |
| GO:BP | GO:0048667 | cell morphogenesis involved in neuron differentiation | 377 | 435 | 4.36e-13 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 840 | 1035 | 4.46e-13 |
| GO:BP | GO:0065008 | regulation of biological quality | 1480 | 1893 | 1.18e-12 |
| GO:BP | GO:0034330 | cell junction organization | 461 | 545 | 3.79e-12 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 1454 | 1862 | 4.53e-12 |
| GO:BP | GO:0048514 | blood vessel morphogenesis | 386 | 450 | 6.46e-12 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | 496 | 591 | 6.75e-12 |
| GO:BP | GO:0098609 | cell-cell adhesion | 475 | 564 | 6.89e-12 |
| GO:BP | GO:0001503 | ossification | 268 | 302 | 8.52e-12 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 957 | 1197 | 8.53e-12 |
| GO:BP | GO:0048519 | negative regulation of biological process | 2841 | 3764 | 8.92e-12 |
| GO:BP | GO:0048589 | developmental growth | 425 | 501 | 1.43e-11 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 2682 | 3550 | 3.51e-11 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | 385 | 452 | 6.08e-11 |
| GO:BP | GO:0072001 | renal system development | 219 | 244 | 1.04e-10 |
| GO:BP | GO:0030155 | regulation of cell adhesion | 428 | 508 | 1.07e-10 |
| GO:BP | GO:0035556 | intracellular signal transduction | 1511 | 1951 | 1.59e-10 |
| GO:BP | GO:0007409 | axonogenesis | 293 | 337 | 2.10e-10 |
| GO:BP | GO:0060429 | epithelium development | 645 | 792 | 2.40e-10 |
| GO:BP | GO:0044057 | regulation of system process | 330 | 384 | 2.44e-10 |
| GO:BP | GO:0007417 | central nervous system development | 570 | 694 | 2.75e-10 |
| GO:BP | GO:0002062 | chondrocyte differentiation | 87 | 88 | 3.70e-10 |
| GO:BP | GO:0001822 | kidney development | 212 | 237 | 5.13e-10 |
| GO:BP | GO:0003013 | circulatory system process | 362 | 426 | 5.59e-10 |
| GO:BP | GO:0010975 | regulation of neuron projection development | 306 | 355 | 6.78e-10 |
| GO:BP | GO:0051960 | regulation of nervous system development | 293 | 339 | 9.50e-10 |
| GO:BP | GO:0061564 | axon development | 319 | 372 | 9.59e-10 |
| GO:BP | GO:0006810 | transport | 2261 | 2984 | 9.59e-10 |
| GO:BP | GO:0051049 | regulation of transport | 873 | 1098 | 1.14e-09 |
| GO:BP | GO:0042221 | response to chemical | 1764 | 2304 | 1.45e-09 |
| GO:BP | GO:0051179 | localization | 2800 | 3731 | 1.60e-09 |
| GO:BP | GO:0120035 | regulation of plasma membrane bounded cell projection organization | 422 | 505 | 1.66e-09 |
| GO:BP | GO:0098657 | import into cell | 512 | 622 | 1.70e-09 |
| GO:BP | GO:0030900 | forebrain development | 239 | 272 | 1.84e-09 |
| GO:BP | GO:0060322 | head development | 448 | 539 | 1.95e-09 |
| GO:BP | GO:0032879 | regulation of localization | 1126 | 1439 | 1.96e-09 |
| GO:BP | GO:0070848 | response to growth factor | 454 | 547 | 2.15e-09 |
| GO:BP | GO:0016055 | Wnt signaling pathway | 307 | 358 | 2.17e-09 |
| GO:BP | GO:0031344 | regulation of cell projection organization | 430 | 516 | 2.26e-09 |
| GO:BP | GO:0001525 | angiogenesis | 325 | 381 | 2.26e-09 |
| GO:BP | GO:0010647 | positive regulation of cell communication | 961 | 1218 | 2.40e-09 |
| GO:BP | GO:0048729 | tissue morphogenesis | 381 | 453 | 2.59e-09 |
| GO:BP | GO:0023056 | positive regulation of signaling | 963 | 1221 | 2.63e-09 |
| GO:BP | GO:0051241 | negative regulation of multicellular organismal process | 575 | 706 | 3.23e-09 |
| GO:BP | GO:0051056 | regulation of small GTPase mediated signal transduction | 207 | 233 | 3.62e-09 |
| GO:BP | GO:0007423 | sensory organ development | 329 | 387 | 3.96e-09 |
| GO:BP | GO:0198738 | cell-cell signaling by wnt | 307 | 359 | 4.12e-09 |
| GO:BP | GO:0001501 | skeletal system development | 297 | 347 | 6.89e-09 |
| GO:BP | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 382 | 456 | 6.97e-09 |
| GO:BP | GO:0007420 | brain development | 414 | 498 | 9.84e-09 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | 437 | 528 | 1.05e-08 |
| GO:BP | GO:0051234 | establishment of localization | 2438 | 3240 | 1.13e-08 |
| GO:BP | GO:0030111 | regulation of Wnt signaling pathway | 228 | 261 | 1.72e-08 |
| GO:BP | GO:0050767 | regulation of neurogenesis | 251 | 290 | 1.77e-08 |
| GO:BP | GO:0061448 | connective tissue development | 183 | 205 | 1.79e-08 |
| GO:BP | GO:0034329 | cell junction assembly | 277 | 323 | 1.82e-08 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | 1350 | 1751 | 2.34e-08 |
| GO:BP | GO:0001667 | ameboidal-type cell migration | 293 | 344 | 2.79e-08 |
| GO:BP | GO:0008015 | blood circulation | 303 | 357 | 3.22e-08 |
| GO:BP | GO:0040013 | negative regulation of locomotion | 213 | 243 | 3.23e-08 |
| GO:BP | GO:0061061 | muscle structure development | 441 | 536 | 4.28e-08 |
| GO:BP | GO:0071310 | cellular response to organic substance | 1013 | 1297 | 4.30e-08 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | 1166 | 1504 | 4.67e-08 |
| GO:BP | GO:0016043 | cellular component organization | 3556 | 4802 | 4.67e-08 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | 861 | 1093 | 4.67e-08 |
| GO:BP | GO:0048598 | embryonic morphogenesis | 353 | 422 | 4.79e-08 |
| GO:BP | GO:0006897 | endocytosis | 407 | 492 | 4.79e-08 |
| GO:BP | GO:0007507 | heart development | 412 | 499 | 6.15e-08 |
| GO:BP | GO:0051216 | cartilage development | 133 | 145 | 6.15e-08 |
| GO:BP | GO:0035265 | organ growth | 118 | 127 | 6.64e-08 |
| GO:BP | GO:0030001 | metal ion transport | 431 | 524 | 6.85e-08 |
| GO:BP | GO:0030029 | actin filament-based process | 519 | 640 | 9.17e-08 |
| GO:BP | GO:0006468 | protein phosphorylation | 757 | 958 | 1.97e-07 |
| GO:BP | GO:0030335 | positive regulation of cell migration | 330 | 395 | 2.27e-07 |
| GO:BP | GO:2000147 | positive regulation of cell motility | 340 | 408 | 2.34e-07 |
| GO:BP | GO:0048638 | regulation of developmental growth | 211 | 243 | 2.36e-07 |
| GO:BP | GO:1901888 | regulation of cell junction assembly | 141 | 156 | 2.55e-07 |
| GO:BP | GO:0060070 | canonical Wnt signaling pathway | 210 | 242 | 2.87e-07 |
| GO:BP | GO:2000146 | negative regulation of cell motility | 190 | 217 | 3.19e-07 |
| GO:BP | GO:0030336 | negative regulation of cell migration | 184 | 210 | 4.95e-07 |
| GO:BP | GO:0099177 | regulation of trans-synaptic signaling | 273 | 323 | 5.14e-07 |
| GO:BP | GO:0016310 | phosphorylation | 894 | 1145 | 5.17e-07 |
| GO:BP | GO:0071417 | cellular response to organonitrogen compound | 365 | 442 | 5.21e-07 |
| GO:BP | GO:0040017 | positive regulation of locomotion | 345 | 416 | 5.21e-07 |
| GO:BP | GO:0043547 | positive regulation of GTPase activity | 105 | 113 | 5.34e-07 |
| GO:BP | GO:0009790 | embryo development | 652 | 821 | 5.82e-07 |
| GO:BP | GO:1903522 | regulation of blood circulation | 171 | 194 | 5.88e-07 |
| GO:BP | GO:0050804 | modulation of chemical synaptic transmission | 272 | 322 | 5.89e-07 |
| GO:BP | GO:0045664 | regulation of neuron differentiation | 119 | 130 | 6.08e-07 |
| GO:BP | GO:0009987 | cellular process | 7680 | 10686 | 6.88e-07 |
| GO:BP | GO:0042592 | homeostatic process | 887 | 1137 | 7.63e-07 |
| GO:BP | GO:0016192 | vesicle-mediated transport | 898 | 1152 | 7.94e-07 |
| GO:BP | GO:0060284 | regulation of cell development | 462 | 570 | 7.94e-07 |
| GO:BP | GO:0002009 | morphogenesis of an epithelium | 308 | 369 | 8.32e-07 |
| GO:BP | GO:0072073 | kidney epithelium development | 103 | 111 | 8.68e-07 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | 603 | 757 | 8.81e-07 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | 999 | 1289 | 9.23e-07 |
| GO:BP | GO:0043087 | regulation of GTPase activity | 148 | 166 | 9.45e-07 |
| GO:BP | GO:0007264 | small GTPase-mediated signal transduction | 324 | 390 | 9.49e-07 |
| GO:BP | GO:0043010 | camera-type eye development | 199 | 230 | 1.11e-06 |
| GO:BP | GO:0031589 | cell-substrate adhesion | 221 | 258 | 1.20e-06 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | 672 | 850 | 1.22e-06 |
| GO:BP | GO:0010243 | response to organonitrogen compound | 548 | 685 | 1.29e-06 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | 927 | 1193 | 1.31e-06 |
| GO:BP | GO:0090132 | epithelium migration | 209 | 243 | 1.39e-06 |
| GO:BP | GO:0010631 | epithelial cell migration | 209 | 243 | 1.39e-06 |
| GO:BP | GO:0048705 | skeletal system morphogenesis | 133 | 148 | 1.50e-06 |
| GO:BP | GO:0001649 | osteoblast differentiation | 154 | 174 | 1.52e-06 |
| GO:BP | GO:0090130 | tissue migration | 212 | 247 | 1.57e-06 |
| GO:BP | GO:0014706 | striated muscle tissue development | 185 | 213 | 1.76e-06 |
| GO:BP | GO:0060828 | regulation of canonical Wnt signaling pathway | 177 | 203 | 1.85e-06 |
| GO:BP | GO:0099537 | trans-synaptic signaling | 382 | 467 | 1.85e-06 |
| GO:BP | GO:0050808 | synapse organization | 282 | 337 | 1.90e-06 |
| GO:BP | GO:0099536 | synaptic signaling | 394 | 483 | 2.08e-06 |
| GO:BP | GO:0040007 | growth | 556 | 697 | 2.08e-06 |
| GO:BP | GO:0023057 | negative regulation of signaling | 809 | 1036 | 2.33e-06 |
| GO:BP | GO:0045165 | cell fate commitment | 135 | 151 | 2.47e-06 |
| GO:BP | GO:0001654 | eye development | 224 | 263 | 2.50e-06 |
| GO:BP | GO:0031214 | biomineral tissue development | 98 | 106 | 2.95e-06 |
| GO:BP | GO:0065009 | regulation of molecular function | 1003 | 1299 | 2.95e-06 |
| GO:BP | GO:0007268 | chemical synaptic transmission | 378 | 463 | 3.20e-06 |
| GO:BP | GO:0098916 | anterograde trans-synaptic signaling | 378 | 463 | 3.20e-06 |
| GO:BP | GO:0048880 | sensory system development | 226 | 266 | 3.30e-06 |
| GO:BP | GO:0021537 | telencephalon development | 170 | 195 | 3.35e-06 |
| GO:BP | GO:0008016 | regulation of heart contraction | 146 | 165 | 3.38e-06 |
| GO:BP | GO:0060560 | developmental growth involved in morphogenesis | 166 | 190 | 3.38e-06 |
| GO:BP | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 240 | 284 | 3.39e-06 |
| GO:BP | GO:1901652 | response to peptide | 305 | 368 | 3.54e-06 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | 456 | 566 | 3.61e-06 |
| GO:BP | GO:0030855 | epithelial cell differentiation | 351 | 428 | 3.63e-06 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | 850 | 1093 | 3.66e-06 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | 1968 | 2622 | 3.98e-06 |
| GO:BP | GO:0010648 | negative regulation of cell communication | 806 | 1034 | 4.01e-06 |
| GO:BP | GO:0003007 | heart morphogenesis | 188 | 218 | 4.02e-06 |
| GO:BP | GO:0048871 | multicellular organismal-level homeostasis | 433 | 536 | 4.09e-06 |
| GO:BP | GO:0003206 | cardiac chamber morphogenesis | 101 | 110 | 4.40e-06 |
| GO:BP | GO:0150063 | visual system development | 224 | 264 | 4.48e-06 |
| GO:BP | GO:0010720 | positive regulation of cell development | 259 | 309 | 4.57e-06 |
| GO:BP | GO:0030278 | regulation of ossification | 75 | 79 | 4.77e-06 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | 220 | 259 | 4.77e-06 |
| GO:BP | GO:0010632 | regulation of epithelial cell migration | 164 | 188 | 4.82e-06 |
| GO:BP | GO:0090596 | sensory organ morphogenesis | 152 | 173 | 4.96e-06 |
| GO:BP | GO:0010033 | response to organic substance | 1322 | 1736 | 5.17e-06 |
| GO:BP | GO:1901698 | response to nitrogen compound | 583 | 736 | 5.60e-06 |
| GO:BP | GO:0098660 | inorganic ion transmembrane transport | 421 | 521 | 5.60e-06 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | 759 | 972 | 5.63e-06 |
| GO:BP | GO:0044093 | positive regulation of molecular function | 618 | 783 | 6.01e-06 |
| GO:BP | GO:0006811 | monoatomic ion transport | 570 | 719 | 6.22e-06 |
| GO:BP | GO:0050770 | regulation of axonogenesis | 113 | 125 | 6.45e-06 |
| GO:BP | GO:0006812 | monoatomic cation transport | 491 | 614 | 6.45e-06 |
| GO:BP | GO:0003205 | cardiac chamber development | 134 | 151 | 7.05e-06 |
| GO:BP | GO:0048639 | positive regulation of developmental growth | 108 | 119 | 7.29e-06 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 3665 | 4988 | 7.88e-06 |
| GO:BP | GO:0048771 | tissue remodeling | 103 | 113 | 8.09e-06 |
| GO:BP | GO:0008150 | biological_process | 8053 | 11244 | 8.24e-06 |
| GO:BP | GO:0098662 | inorganic cation transmembrane transport | 389 | 480 | 8.92e-06 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | 442 | 550 | 9.09e-06 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | 376 | 463 | 9.22e-06 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | 376 | 463 | 9.22e-06 |
| GO:BP | GO:0060047 | heart contraction | 168 | 194 | 9.64e-06 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | 388 | 479 | 1.01e-05 |
| GO:BP | GO:0007186 | G protein-coupled receptor signaling pathway | 317 | 386 | 1.06e-05 |
| GO:BP | GO:0034220 | monoatomic ion transmembrane transport | 469 | 587 | 1.45e-05 |
| GO:BP | GO:0007010 | cytoskeleton organization | 885 | 1146 | 1.58e-05 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | 173 | 201 | 1.58e-05 |
| GO:BP | GO:0071560 | cellular response to transforming growth factor beta stimulus | 184 | 215 | 1.61e-05 |
| GO:BP | GO:0097485 | neuron projection guidance | 150 | 172 | 1.61e-05 |
| GO:BP | GO:0007411 | axon guidance | 150 | 172 | 1.61e-05 |
| GO:BP | GO:0043434 | response to peptide hormone | 261 | 314 | 1.62e-05 |
| GO:BP | GO:0035108 | limb morphogenesis | 100 | 110 | 1.62e-05 |
| GO:BP | GO:0035107 | appendage morphogenesis | 100 | 110 | 1.62e-05 |
| GO:BP | GO:0043062 | extracellular structure organization | 191 | 224 | 1.66e-05 |
| GO:BP | GO:0045229 | external encapsulating structure organization | 191 | 224 | 1.66e-05 |
| GO:BP | GO:0060627 | regulation of vesicle-mediated transport | 307 | 374 | 1.72e-05 |
| GO:BP | GO:0071559 | response to transforming growth factor beta | 187 | 219 | 1.76e-05 |
| GO:BP | GO:0003231 | cardiac ventricle development | 104 | 115 | 1.79e-05 |
| GO:BP | GO:0050673 | epithelial cell proliferation | 250 | 300 | 1.81e-05 |
| GO:BP | GO:0097435 | supramolecular fiber organization | 503 | 633 | 1.84e-05 |
| GO:BP | GO:0060411 | cardiac septum morphogenesis | 64 | 67 | 1.93e-05 |
| GO:BP | GO:0030198 | extracellular matrix organization | 190 | 223 | 1.95e-05 |
| GO:BP | GO:0050877 | nervous system process | 478 | 600 | 2.01e-05 |
| GO:BP | GO:0007389 | pattern specification process | 239 | 286 | 2.02e-05 |
| GO:BP | GO:0003015 | heart process | 175 | 204 | 2.07e-05 |
| GO:BP | GO:0048568 | embryonic organ development | 252 | 303 | 2.23e-05 |
| GO:BP | GO:0030178 | negative regulation of Wnt signaling pathway | 120 | 135 | 2.28e-05 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 1810 | 2415 | 2.60e-05 |
| GO:BP | GO:0030010 | establishment of cell polarity | 111 | 124 | 2.60e-05 |
| GO:BP | GO:0048588 | developmental cell growth | 155 | 179 | 2.61e-05 |
| GO:BP | GO:0007160 | cell-matrix adhesion | 147 | 169 | 2.79e-05 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | 209 | 248 | 2.92e-05 |
| GO:BP | GO:0098655 | monoatomic cation transmembrane transport | 398 | 495 | 3.00e-05 |
| GO:BP | GO:0060562 | epithelial tube morphogenesis | 219 | 261 | 3.14e-05 |
| GO:BP | GO:0048592 | eye morphogenesis | 97 | 107 | 3.16e-05 |
| GO:BP | GO:0035023 | regulation of Rho protein signal transduction | 62 | 65 | 3.31e-05 |
| GO:BP | GO:0044089 | positive regulation of cellular component biogenesis | 318 | 390 | 3.48e-05 |
| GO:BP | GO:0022407 | regulation of cell-cell adhesion | 232 | 278 | 3.53e-05 |
| GO:BP | GO:0008283 | cell population proliferation | 1000 | 1306 | 3.75e-05 |
| GO:BP | GO:0042391 | regulation of membrane potential | 235 | 282 | 3.76e-05 |
| GO:BP | GO:0090257 | regulation of muscle system process | 153 | 177 | 3.77e-05 |
| GO:BP | GO:0043408 | regulation of MAPK cascade | 346 | 427 | 3.77e-05 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | 623 | 796 | 3.90e-05 |
| GO:BP | GO:0006793 | phosphorus metabolic process | 1437 | 1904 | 3.96e-05 |
| GO:BP | GO:0048762 | mesenchymal cell differentiation | 171 | 200 | 4.20e-05 |
| GO:BP | GO:0002065 | columnar/cuboidal epithelial cell differentiation | 76 | 82 | 5.49e-05 |
| GO:BP | GO:0042330 | taxis | 205 | 244 | 5.62e-05 |
| GO:BP | GO:0006935 | chemotaxis | 205 | 244 | 5.62e-05 |
| GO:BP | GO:0045785 | positive regulation of cell adhesion | 249 | 301 | 5.82e-05 |
| GO:BP | GO:0072006 | nephron development | 103 | 115 | 5.86e-05 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | 1420 | 1883 | 6.23e-05 |
| GO:BP | GO:0060537 | muscle tissue development | 278 | 339 | 6.40e-05 |
| GO:BP | GO:0051173 | positive regulation of nitrogen compound metabolic process | 1640 | 2186 | 6.55e-05 |
| GO:BP | GO:0031399 | regulation of protein modification process | 707 | 911 | 6.56e-05 |
| GO:BP | GO:0003281 | ventricular septum development | 65 | 69 | 6.56e-05 |
| GO:BP | GO:0030326 | embryonic limb morphogenesis | 80 | 87 | 6.61e-05 |
| GO:BP | GO:0035113 | embryonic appendage morphogenesis | 80 | 87 | 6.61e-05 |
| GO:BP | GO:0045667 | regulation of osteoblast differentiation | 89 | 98 | 7.03e-05 |
| GO:BP | GO:0070167 | regulation of biomineral tissue development | 59 | 62 | 7.48e-05 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | 829 | 1077 | 8.19e-05 |
| GO:BP | GO:0034762 | regulation of transmembrane transport | 246 | 298 | 9.01e-05 |
| GO:BP | GO:0001823 | mesonephros development | 69 | 74 | 9.01e-05 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | 706 | 911 | 9.37e-05 |
| GO:BP | GO:0031325 | positive regulation of cellular metabolic process | 1745 | 2333 | 9.39e-05 |
| GO:BP | GO:0046903 | secretion | 491 | 622 | 9.45e-05 |
| GO:BP | GO:0060485 | mesenchyme development | 205 | 245 | 9.67e-05 |
| GO:BP | GO:0003279 | cardiac septum development | 92 | 102 | 9.77e-05 |
| GO:BP | GO:0007159 | leukocyte cell-cell adhesion | 184 | 218 | 9.81e-05 |
| GO:BP | GO:0032835 | glomerulus development | 52 | 54 | 1.02e-04 |
| GO:BP | GO:0042327 | positive regulation of phosphorylation | 335 | 415 | 1.03e-04 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | 627 | 805 | 1.08e-04 |
| GO:BP | GO:0055123 | digestive system development | 87 | 96 | 1.11e-04 |
| GO:BP | GO:0072163 | mesonephric epithelium development | 68 | 73 | 1.14e-04 |
| GO:BP | GO:0072164 | mesonephric tubule development | 68 | 73 | 1.14e-04 |
| GO:BP | GO:0000165 | MAPK cascade | 402 | 504 | 1.14e-04 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | 626 | 804 | 1.18e-04 |
| GO:BP | GO:0051962 | positive regulation of nervous system development | 179 | 212 | 1.25e-04 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | 440 | 555 | 1.32e-04 |
| GO:BP | GO:0003012 | muscle system process | 266 | 325 | 1.35e-04 |
| GO:BP | GO:0150115 | cell-substrate junction organization | 86 | 95 | 1.39e-04 |
| GO:BP | GO:0030282 | bone mineralization | 72 | 78 | 1.44e-04 |
| GO:BP | GO:0140352 | export from cell | 469 | 594 | 1.45e-04 |
| GO:BP | GO:0001657 | ureteric bud development | 67 | 72 | 1.46e-04 |
| GO:BP | GO:0007610 | behavior | 338 | 420 | 1.53e-04 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | 156 | 183 | 1.62e-04 |
| GO:BP | GO:0014855 | striated muscle cell proliferation | 56 | 59 | 1.66e-04 |
| GO:BP | GO:0001763 | morphogenesis of a branching structure | 126 | 145 | 1.68e-04 |
| GO:BP | GO:0010463 | mesenchymal cell proliferation | 36 | 36 | 1.79e-04 |
| GO:BP | GO:0051336 | regulation of hydrolase activity | 346 | 431 | 1.79e-04 |
| GO:BP | GO:0050807 | regulation of synapse organization | 148 | 173 | 1.83e-04 |
| GO:BP | GO:0030100 | regulation of endocytosis | 166 | 196 | 1.84e-04 |
| GO:BP | GO:0007517 | muscle organ development | 221 | 267 | 1.84e-04 |
| GO:BP | GO:0003002 | regionalization | 214 | 258 | 1.92e-04 |
| GO:BP | GO:0048565 | digestive tract development | 80 | 88 | 1.94e-04 |
| GO:BP | GO:0007259 | receptor signaling pathway via JAK-STAT | 80 | 88 | 1.94e-04 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | 80 | 88 | 1.94e-04 |
| GO:BP | GO:0048167 | regulation of synaptic plasticity | 121 | 139 | 2.06e-04 |
| GO:BP | GO:0051961 | negative regulation of nervous system development | 97 | 109 | 2.06e-04 |
| GO:BP | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 97 | 109 | 2.06e-04 |
| GO:BP | GO:0009605 | response to external stimulus | 1179 | 1559 | 2.07e-04 |
| GO:BP | GO:1990138 | neuron projection extension | 117 | 134 | 2.10e-04 |
| GO:BP | GO:0001764 | neuron migration | 113 | 129 | 2.13e-04 |
| GO:BP | GO:0043085 | positive regulation of catalytic activity | 432 | 546 | 2.23e-04 |
| GO:BP | GO:0001934 | positive regulation of protein phosphorylation | 319 | 396 | 2.28e-04 |
| GO:BP | GO:0055017 | cardiac muscle tissue growth | 60 | 64 | 2.33e-04 |
| GO:BP | GO:0046622 | positive regulation of organ growth | 35 | 35 | 2.39e-04 |
| GO:BP | GO:0050803 | regulation of synapse structure or activity | 150 | 176 | 2.39e-04 |
| GO:BP | GO:0048593 | camera-type eye morphogenesis | 79 | 87 | 2.41e-04 |
| GO:BP | GO:0050768 | negative regulation of neurogenesis | 92 | 103 | 2.42e-04 |
| GO:BP | GO:0007162 | negative regulation of cell adhesion | 157 | 185 | 2.46e-04 |
| GO:BP | GO:0051641 | cellular localization | 1950 | 2623 | 2.46e-04 |
| GO:BP | GO:0043269 | regulation of monoatomic ion transport | 232 | 282 | 2.48e-04 |
| GO:BP | GO:0050920 | regulation of chemotaxis | 116 | 133 | 2.51e-04 |
| GO:BP | GO:0031346 | positive regulation of cell projection organization | 235 | 286 | 2.58e-04 |
| GO:BP | GO:0033002 | muscle cell proliferation | 131 | 152 | 2.62e-04 |
| GO:BP | GO:1901653 | cellular response to peptide | 225 | 273 | 2.62e-04 |
| GO:BP | GO:0045666 | positive regulation of neuron differentiation | 54 | 57 | 2.73e-04 |
| GO:BP | GO:0055085 | transmembrane transport | 710 | 921 | 2.77e-04 |
| GO:BP | GO:0042063 | gliogenesis | 201 | 242 | 2.88e-04 |
| GO:BP | GO:0050769 | positive regulation of neurogenesis | 156 | 184 | 2.88e-04 |
| GO:BP | GO:0061035 | regulation of cartilage development | 48 | 50 | 2.96e-04 |
| GO:BP | GO:0007229 | integrin-mediated signaling pathway | 78 | 86 | 2.97e-04 |
| GO:BP | GO:0009725 | response to hormone | 479 | 610 | 3.10e-04 |
| GO:BP | GO:0016331 | morphogenesis of embryonic epithelium | 107 | 122 | 3.12e-04 |
| GO:BP | GO:0032330 | regulation of chondrocyte differentiation | 34 | 34 | 3.19e-04 |
| GO:BP | GO:0097696 | receptor signaling pathway via STAT | 82 | 91 | 3.25e-04 |
| GO:BP | GO:0016358 | dendrite development | 155 | 183 | 3.40e-04 |
| GO:BP | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 176 | 210 | 3.40e-04 |
| GO:BP | GO:0050678 | regulation of epithelial cell proliferation | 206 | 249 | 3.70e-04 |
| GO:BP | GO:0060993 | kidney morphogenesis | 63 | 68 | 3.81e-04 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | 245 | 300 | 3.88e-04 |
| GO:BP | GO:0010721 | negative regulation of cell development | 154 | 182 | 4.03e-04 |
| GO:BP | GO:0001952 | regulation of cell-matrix adhesion | 81 | 90 | 4.08e-04 |
| GO:BP | GO:0061138 | morphogenesis of a branching epithelium | 117 | 135 | 4.31e-04 |
| GO:BP | GO:0032940 | secretion by cell | 434 | 551 | 4.55e-04 |
| GO:BP | GO:0051057 | positive regulation of small GTPase mediated signal transduction | 52 | 55 | 4.65e-04 |
| GO:BP | GO:0007015 | actin filament organization | 288 | 357 | 4.70e-04 |
| GO:BP | GO:0072009 | nephron epithelium development | 76 | 84 | 4.70e-04 |
| GO:BP | GO:0001656 | metanephros development | 57 | 61 | 4.93e-04 |
| GO:BP | GO:0042325 | regulation of phosphorylation | 532 | 683 | 5.17e-04 |
| GO:BP | GO:0030500 | regulation of bone mineralization | 46 | 48 | 5.17e-04 |
| GO:BP | GO:0003018 | vascular process in circulatory system | 163 | 194 | 5.18e-04 |
| GO:BP | GO:0007179 | transforming growth factor beta receptor signaling pathway | 145 | 171 | 5.55e-04 |
| GO:BP | GO:1901342 | regulation of vasculature development | 166 | 198 | 5.59e-04 |
| GO:BP | GO:0021953 | central nervous system neuron differentiation | 88 | 99 | 5.59e-04 |
| GO:BP | GO:0007266 | Rho protein signal transduction | 96 | 109 | 5.76e-04 |
| GO:BP | GO:0001775 | cell activation | 490 | 627 | 5.92e-04 |
| GO:BP | GO:0045216 | cell-cell junction organization | 130 | 152 | 6.10e-04 |
| GO:BP | GO:0031032 | actomyosin structure organization | 155 | 184 | 6.10e-04 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | 56 | 60 | 6.33e-04 |
| GO:BP | GO:0018105 | peptidyl-serine phosphorylation | 137 | 161 | 6.34e-04 |
| GO:BP | GO:0002521 | leukocyte differentiation | 298 | 371 | 6.34e-04 |
| GO:BP | GO:1903037 | regulation of leukocyte cell-cell adhesion | 165 | 197 | 6.49e-04 |
| GO:BP | GO:0060412 | ventricular septum morphogenesis | 39 | 40 | 6.49e-04 |
| GO:BP | GO:0051050 | positive regulation of transport | 448 | 571 | 6.53e-04 |
| GO:BP | GO:0048041 | focal adhesion assembly | 70 | 77 | 6.59e-04 |
| GO:BP | GO:0021987 | cerebral cortex development | 83 | 93 | 6.59e-04 |
| GO:BP | GO:0006816 | calcium ion transport | 215 | 262 | 6.66e-04 |
| GO:BP | GO:0051345 | positive regulation of hydrolase activity | 218 | 266 | 6.91e-04 |
| GO:BP | GO:0043542 | endothelial cell migration | 147 | 174 | 7.07e-04 |
| GO:BP | GO:0043583 | ear development | 129 | 151 | 7.16e-04 |
| GO:BP | GO:1902533 | positive regulation of intracellular signal transduction | 554 | 714 | 7.24e-04 |
| GO:BP | GO:0060419 | heart growth | 65 | 71 | 7.27e-04 |
| GO:BP | GO:0018209 | peptidyl-serine modification | 143 | 169 | 7.61e-04 |
| GO:BP | GO:0060043 | regulation of cardiac muscle cell proliferation | 31 | 31 | 8.05e-04 |
| GO:BP | GO:0018212 | peptidyl-tyrosine modification | 139 | 164 | 8.23e-04 |
| GO:BP | GO:0006898 | receptor-mediated endocytosis | 153 | 182 | 8.31e-04 |
| GO:BP | GO:0010959 | regulation of metal ion transport | 197 | 239 | 8.31e-04 |
| GO:BP | GO:0098771 | inorganic ion homeostasis | 280 | 348 | 8.43e-04 |
| GO:BP | GO:0010594 | regulation of endothelial cell migration | 117 | 136 | 8.45e-04 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | 344 | 433 | 8.75e-04 |
| GO:BP | GO:0046620 | regulation of organ growth | 64 | 70 | 9.22e-04 |
| GO:BP | GO:0043068 | positive regulation of programmed cell death | 310 | 388 | 9.34e-04 |
| GO:BP | GO:0050772 | positive regulation of axonogenesis | 59 | 64 | 1.00e-03 |
| GO:BP | GO:0048645 | animal organ formation | 49 | 52 | 1.00e-03 |
| GO:BP | GO:0021543 | pallium development | 116 | 135 | 1.02e-03 |
| GO:BP | GO:0045765 | regulation of angiogenesis | 162 | 194 | 1.03e-03 |
| GO:BP | GO:0090066 | regulation of anatomical structure size | 303 | 379 | 1.03e-03 |
| GO:BP | GO:0043410 | positive regulation of MAPK cascade | 234 | 288 | 1.08e-03 |
| GO:BP | GO:0098900 | regulation of action potential | 37 | 38 | 1.15e-03 |
| GO:BP | GO:0010810 | regulation of cell-substrate adhesion | 137 | 162 | 1.15e-03 |
| GO:BP | GO:0018108 | peptidyl-tyrosine phosphorylation | 137 | 162 | 1.15e-03 |
| GO:BP | GO:0061005 | cell differentiation involved in kidney development | 37 | 38 | 1.15e-03 |
| GO:BP | GO:0010717 | regulation of epithelial to mesenchymal transition | 76 | 85 | 1.20e-03 |
| GO:BP | GO:0022604 | regulation of cell morphogenesis | 161 | 193 | 1.20e-03 |
| GO:BP | GO:0032409 | regulation of transporter activity | 126 | 148 | 1.20e-03 |
| GO:BP | GO:0030177 | positive regulation of Wnt signaling pathway | 96 | 110 | 1.23e-03 |
| GO:BP | GO:0043588 | skin development | 147 | 175 | 1.24e-03 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | 499 | 642 | 1.27e-03 |
| GO:BP | GO:0070588 | calcium ion transmembrane transport | 174 | 210 | 1.29e-03 |
| GO:BP | GO:0010633 | negative regulation of epithelial cell migration | 48 | 51 | 1.29e-03 |
| GO:BP | GO:0061326 | renal tubule development | 67 | 74 | 1.29e-03 |
| GO:BP | GO:0021954 | central nervous system neuron development | 53 | 57 | 1.31e-03 |
| GO:BP | GO:0035148 | tube formation | 107 | 124 | 1.33e-03 |
| GO:BP | GO:0061351 | neural precursor cell proliferation | 103 | 119 | 1.39e-03 |
| GO:BP | GO:0071375 | cellular response to peptide hormone stimulus | 190 | 231 | 1.39e-03 |
| GO:BP | GO:0042692 | muscle cell differentiation | 260 | 323 | 1.43e-03 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | 1197 | 1595 | 1.44e-03 |
| GO:BP | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | 29 | 29 | 1.47e-03 |
| GO:BP | GO:0044409 | symbiont entry into host | 95 | 109 | 1.48e-03 |
| GO:BP | GO:0055021 | regulation of cardiac muscle tissue growth | 42 | 44 | 1.49e-03 |
| GO:BP | GO:0008284 | positive regulation of cell population proliferation | 471 | 605 | 1.52e-03 |
| GO:BP | GO:0006814 | sodium ion transport | 117 | 137 | 1.61e-03 |
| GO:BP | GO:0071772 | response to BMP | 102 | 118 | 1.67e-03 |
| GO:BP | GO:0060348 | bone development | 124 | 146 | 1.67e-03 |
| GO:BP | GO:0048008 | platelet-derived growth factor receptor signaling pathway | 47 | 50 | 1.67e-03 |
| GO:BP | GO:0071773 | cellular response to BMP stimulus | 102 | 118 | 1.67e-03 |
| GO:BP | GO:0050900 | leukocyte migration | 162 | 195 | 1.70e-03 |
| GO:BP | GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 98 | 113 | 1.73e-03 |
| GO:BP | GO:1901343 | negative regulation of vasculature development | 61 | 67 | 1.82e-03 |
| GO:BP | GO:2000181 | negative regulation of blood vessel morphogenesis | 61 | 67 | 1.82e-03 |
| GO:BP | GO:0003151 | outflow tract morphogenesis | 61 | 67 | 1.82e-03 |
| GO:BP | GO:0022612 | gland morphogenesis | 82 | 93 | 1.87e-03 |
| GO:BP | GO:0007416 | synapse assembly | 116 | 136 | 1.91e-03 |
| GO:BP | GO:0045665 | negative regulation of neuron differentiation | 41 | 43 | 1.95e-03 |
| GO:BP | GO:0060038 | cardiac muscle cell proliferation | 41 | 43 | 1.95e-03 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | 369 | 469 | 1.98e-03 |
| GO:BP | GO:0060421 | positive regulation of heart growth | 28 | 28 | 1.99e-03 |
| GO:BP | GO:0072175 | epithelial tube formation | 101 | 117 | 1.99e-03 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | 65 | 72 | 1.99e-03 |
| GO:BP | GO:0061614 | miRNA transcription | 56 | 61 | 1.99e-03 |
| GO:BP | GO:0060420 | regulation of heart growth | 46 | 49 | 2.11e-03 |
| GO:BP | GO:0090109 | regulation of cell-substrate junction assembly | 51 | 55 | 2.11e-03 |
| GO:BP | GO:1903053 | regulation of extracellular matrix organization | 46 | 49 | 2.11e-03 |
| GO:BP | GO:0051893 | regulation of focal adhesion assembly | 51 | 55 | 2.11e-03 |
| GO:BP | GO:0030048 | actin filament-based movement | 93 | 107 | 2.14e-03 |
| GO:BP | GO:0030097 | hemopoiesis | 484 | 624 | 2.20e-03 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | 225 | 278 | 2.21e-03 |
| GO:BP | GO:0110020 | regulation of actomyosin structure organization | 77 | 87 | 2.24e-03 |
| GO:BP | GO:0010586 | miRNA metabolic process | 77 | 87 | 2.24e-03 |
| GO:BP | GO:0043065 | positive regulation of apoptotic process | 302 | 380 | 2.24e-03 |
| GO:BP | GO:0016525 | negative regulation of angiogenesis | 60 | 66 | 2.25e-03 |
| GO:BP | GO:0060541 | respiratory system development | 136 | 162 | 2.30e-03 |
| GO:BP | GO:0034765 | regulation of monoatomic ion transmembrane transport | 173 | 210 | 2.34e-03 |
| GO:BP | GO:1904062 | regulation of monoatomic cation transmembrane transport | 156 | 188 | 2.47e-03 |
| GO:BP | GO:0022898 | regulation of transmembrane transporter activity | 118 | 139 | 2.47e-03 |
| GO:BP | GO:0050790 | regulation of catalytic activity | 682 | 893 | 2.49e-03 |
| GO:BP | GO:0150116 | regulation of cell-substrate junction organization | 55 | 60 | 2.49e-03 |
| GO:BP | GO:0002064 | epithelial cell development | 125 | 148 | 2.49e-03 |
| GO:BP | GO:0071407 | cellular response to organic cyclic compound | 301 | 379 | 2.49e-03 |
| GO:BP | GO:0008360 | regulation of cell shape | 92 | 106 | 2.55e-03 |
| GO:BP | GO:0051963 | regulation of synapse assembly | 68 | 76 | 2.59e-03 |
| GO:BP | GO:1901890 | positive regulation of cell junction assembly | 68 | 76 | 2.59e-03 |
| GO:BP | GO:0045663 | positive regulation of myoblast differentiation | 34 | 35 | 2.59e-03 |
| GO:BP | GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 114 | 134 | 2.62e-03 |
| GO:BP | GO:0098901 | regulation of cardiac muscle cell action potential | 27 | 27 | 2.64e-03 |
| GO:BP | GO:0010464 | regulation of mesenchymal cell proliferation | 27 | 27 | 2.64e-03 |
| GO:BP | GO:0006942 | regulation of striated muscle contraction | 72 | 81 | 2.66e-03 |
| GO:BP | GO:0010976 | positive regulation of neuron projection development | 110 | 129 | 2.79e-03 |
| GO:BP | GO:0055117 | regulation of cardiac muscle contraction | 59 | 65 | 2.79e-03 |
| GO:BP | GO:0008361 | regulation of cell size | 124 | 147 | 2.92e-03 |
| GO:BP | GO:0030509 | BMP signaling pathway | 95 | 110 | 2.94e-03 |
| GO:BP | GO:0072080 | nephron tubule development | 63 | 70 | 3.04e-03 |
| GO:BP | GO:0046849 | bone remodeling | 54 | 59 | 3.14e-03 |
| GO:BP | GO:0071695 | anatomical structure maturation | 127 | 151 | 3.16e-03 |
| GO:BP | GO:0032101 | regulation of response to external stimulus | 505 | 654 | 3.25e-03 |
| GO:BP | GO:0060840 | artery development | 75 | 85 | 3.32e-03 |
| GO:BP | GO:0061337 | cardiac conduction | 75 | 85 | 3.32e-03 |
| GO:BP | GO:0033135 | regulation of peptidyl-serine phosphorylation | 75 | 85 | 3.32e-03 |
| GO:BP | GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 123 | 146 | 3.43e-03 |
| GO:BP | GO:0061572 | actin filament bundle organization | 112 | 132 | 3.69e-03 |
| GO:BP | GO:0036211 | protein modification process | 1696 | 2291 | 3.69e-03 |
| GO:BP | GO:0014013 | regulation of gliogenesis | 62 | 69 | 3.80e-03 |
| GO:BP | GO:0043270 | positive regulation of monoatomic ion transport | 108 | 127 | 3.95e-03 |
| GO:BP | GO:0061333 | renal tubule morphogenesis | 53 | 58 | 3.95e-03 |
| GO:BP | GO:0072028 | nephron morphogenesis | 53 | 58 | 3.95e-03 |
| GO:BP | GO:0048864 | stem cell development | 66 | 74 | 3.95e-03 |
| GO:BP | GO:0010634 | positive regulation of epithelial cell migration | 108 | 127 | 3.95e-03 |
| GO:BP | GO:0014897 | striated muscle hypertrophy | 66 | 74 | 3.95e-03 |
| GO:BP | GO:0098727 | maintenance of cell number | 122 | 145 | 4.00e-03 |
| GO:BP | GO:0031345 | negative regulation of cell projection organization | 122 | 145 | 4.00e-03 |
| GO:BP | GO:0031623 | receptor internalization | 78 | 89 | 4.00e-03 |
| GO:BP | GO:0060173 | limb development | 115 | 136 | 4.00e-03 |
| GO:BP | GO:0048736 | appendage development | 115 | 136 | 4.00e-03 |
| GO:BP | GO:0042476 | odontogenesis | 70 | 79 | 4.00e-03 |
| GO:BP | GO:0048878 | chemical homeostasis | 516 | 670 | 4.18e-03 |
| GO:BP | GO:0000003 | reproduction | 672 | 882 | 4.19e-03 |
| GO:BP | GO:0045669 | positive regulation of osteoblast differentiation | 48 | 52 | 4.27e-03 |
| GO:BP | GO:0051017 | actin filament bundle assembly | 111 | 131 | 4.30e-03 |
| GO:BP | GO:0046718 | symbiont entry into host cell | 89 | 103 | 4.40e-03 |
| GO:BP | GO:0060350 | endochondral bone morphogenesis | 43 | 46 | 4.41e-03 |
| GO:BP | GO:0006937 | regulation of muscle contraction | 107 | 126 | 4.64e-03 |
| GO:BP | GO:0030324 | lung development | 121 | 144 | 4.68e-03 |
| GO:BP | GO:0031099 | regeneration | 121 | 144 | 4.68e-03 |
| GO:BP | GO:0003300 | cardiac muscle hypertrophy | 65 | 73 | 4.84e-03 |
| GO:BP | GO:0060349 | bone morphogenesis | 65 | 73 | 4.84e-03 |
| GO:BP | GO:0055023 | positive regulation of cardiac muscle tissue growth | 25 | 25 | 4.84e-03 |
| GO:BP | GO:0055006 | cardiac cell development | 69 | 78 | 4.91e-03 |
| GO:BP | GO:0050890 | cognition | 174 | 213 | 4.91e-03 |
| GO:BP | GO:0030323 | respiratory tube development | 124 | 148 | 5.02e-03 |
| GO:BP | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 127 | 152 | 5.40e-03 |
| GO:BP | GO:0042733 | embryonic digit morphogenesis | 47 | 51 | 5.44e-03 |
| GO:BP | GO:0003208 | cardiac ventricle morphogenesis | 56 | 62 | 5.44e-03 |
| GO:BP | GO:0045778 | positive regulation of ossification | 37 | 39 | 5.46e-03 |
| GO:BP | GO:0019827 | stem cell population maintenance | 120 | 143 | 5.48e-03 |
| GO:BP | GO:0040008 | regulation of growth | 361 | 462 | 5.58e-03 |
| GO:BP | GO:0042981 | regulation of apoptotic process | 780 | 1031 | 5.58e-03 |
| GO:BP | GO:0023061 | signal release | 251 | 315 | 5.62e-03 |
| GO:BP | GO:0010628 | positive regulation of gene expression | 571 | 746 | 5.64e-03 |
| GO:BP | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 80 | 92 | 5.70e-03 |
| GO:BP | GO:0071805 | potassium ion transmembrane transport | 102 | 120 | 5.86e-03 |
| GO:BP | GO:0086004 | regulation of cardiac muscle cell contraction | 31 | 32 | 5.94e-03 |
| GO:BP | GO:0001838 | embryonic epithelial tube formation | 91 | 106 | 5.94e-03 |
| GO:BP | GO:0035850 | epithelial cell differentiation involved in kidney development | 31 | 32 | 5.94e-03 |
| GO:BP | GO:0007043 | cell-cell junction assembly | 91 | 106 | 5.94e-03 |
| GO:BP | GO:0014033 | neural crest cell differentiation | 68 | 77 | 5.96e-03 |
| GO:BP | GO:0072088 | nephron epithelium morphogenesis | 51 | 56 | 6.14e-03 |
| GO:BP | GO:0048708 | astrocyte differentiation | 51 | 56 | 6.14e-03 |
| GO:BP | GO:0010817 | regulation of hormone levels | 253 | 318 | 6.26e-03 |
| GO:BP | GO:0003006 | developmental process involved in reproduction | 443 | 573 | 6.28e-03 |
| GO:BP | GO:0001894 | tissue homeostasis | 136 | 164 | 6.30e-03 |
| GO:BP | GO:0060249 | anatomical structure homeostasis | 136 | 164 | 6.30e-03 |
| GO:BP | GO:0046777 | protein autophosphorylation | 119 | 142 | 6.32e-03 |
| GO:BP | GO:0048839 | inner ear development | 112 | 133 | 6.38e-03 |
| GO:BP | GO:0071875 | adrenergic receptor signaling pathway | 24 | 24 | 6.47e-03 |
| GO:BP | GO:0098868 | bone growth | 24 | 24 | 6.47e-03 |
| GO:BP | GO:0010001 | glial cell differentiation | 149 | 181 | 6.53e-03 |
| GO:BP | GO:0048469 | cell maturation | 94 | 110 | 6.60e-03 |
| GO:BP | GO:0031016 | pancreas development | 46 | 50 | 6.74e-03 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | 46 | 50 | 6.74e-03 |
| GO:BP | GO:0030038 | contractile actin filament bundle assembly | 79 | 91 | 6.76e-03 |
| GO:BP | GO:0043149 | stress fiber assembly | 79 | 91 | 6.76e-03 |
| GO:BP | GO:0007272 | ensheathment of neurons | 101 | 119 | 6.78e-03 |
| GO:BP | GO:0008366 | axon ensheathment | 101 | 119 | 6.78e-03 |
| GO:BP | GO:0001837 | epithelial to mesenchymal transition | 115 | 137 | 6.81e-03 |
| GO:BP | GO:0010596 | negative regulation of endothelial cell migration | 36 | 38 | 6.91e-03 |
| GO:BP | GO:0090100 | positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 75 | 86 | 6.95e-03 |
| GO:BP | GO:0060041 | retina development in camera-type eye | 90 | 105 | 6.95e-03 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | 41 | 44 | 7.04e-03 |
| GO:BP | GO:0034103 | regulation of tissue remodeling | 41 | 44 | 7.04e-03 |
| GO:BP | GO:0022414 | reproductive process | 664 | 874 | 7.20e-03 |
| GO:BP | GO:0043067 | regulation of programmed cell death | 800 | 1060 | 7.23e-03 |
| GO:BP | GO:0060341 | regulation of cellular localization | 592 | 776 | 7.41e-03 |
| GO:BP | GO:0003179 | heart valve morphogenesis | 50 | 55 | 7.57e-03 |
| GO:BP | GO:0048732 | gland development | 245 | 308 | 7.60e-03 |
| GO:BP | GO:0021955 | central nervous system neuron axonogenesis | 30 | 31 | 7.69e-03 |
| GO:BP | GO:0035725 | sodium ion transmembrane transport | 82 | 95 | 7.72e-03 |
| GO:BP | GO:0010977 | negative regulation of neuron projection development | 93 | 109 | 7.74e-03 |
| GO:BP | GO:0061458 | reproductive system development | 167 | 205 | 7.87e-03 |
| GO:BP | GO:0008544 | epidermis development | 170 | 209 | 8.09e-03 |
| GO:BP | GO:0021675 | nerve development | 54 | 60 | 8.17e-03 |
| GO:BP | GO:1990778 | protein localization to cell periphery | 229 | 287 | 8.29e-03 |
| GO:BP | GO:0032231 | regulation of actin filament bundle assembly | 74 | 85 | 8.37e-03 |
| GO:BP | GO:0007369 | gastrulation | 117 | 140 | 8.48e-03 |
| GO:BP | GO:0003170 | heart valve development | 58 | 65 | 8.52e-03 |
| GO:BP | GO:0060291 | long-term synaptic potentiation | 58 | 65 | 8.52e-03 |
| GO:BP | GO:0048754 | branching morphogenesis of an epithelial tube | 96 | 113 | 8.54e-03 |
| GO:BP | GO:0051924 | regulation of calcium ion transport | 127 | 153 | 8.56e-03 |
| GO:BP | GO:0061036 | positive regulation of cartilage development | 23 | 23 | 8.56e-03 |
| GO:BP | GO:0003416 | endochondral bone growth | 23 | 23 | 8.56e-03 |
| GO:BP | GO:0002685 | regulation of leukocyte migration | 103 | 122 | 8.56e-03 |
| GO:BP | GO:0002063 | chondrocyte development | 23 | 23 | 8.56e-03 |
| GO:BP | GO:0060037 | pharyngeal system development | 23 | 23 | 8.56e-03 |
| GO:BP | GO:0097553 | calcium ion transmembrane import into cytosol | 103 | 122 | 8.56e-03 |
| GO:BP | GO:0014896 | muscle hypertrophy | 66 | 75 | 8.57e-03 |
| GO:BP | GO:0090288 | negative regulation of cellular response to growth factor stimulus | 66 | 75 | 8.57e-03 |
| GO:BP | GO:0031328 | positive regulation of cellular biosynthetic process | 1366 | 1841 | 8.68e-03 |
| GO:BP | GO:1903115 | regulation of actin filament-based movement | 35 | 37 | 8.77e-03 |
| GO:BP | GO:0002090 | regulation of receptor internalization | 40 | 43 | 8.85e-03 |
| GO:BP | GO:0045321 | leukocyte activation | 410 | 530 | 8.87e-03 |
| GO:BP | GO:0006813 | potassium ion transport | 113 | 135 | 9.08e-03 |
| GO:BP | GO:0050870 | positive regulation of T cell activation | 113 | 135 | 9.08e-03 |
| GO:BP | GO:0051051 | negative regulation of transport | 228 | 286 | 9.08e-03 |
| GO:BP | GO:0042552 | myelination | 99 | 117 | 9.19e-03 |
| GO:BP | GO:0014910 | regulation of smooth muscle cell migration | 49 | 54 | 9.22e-03 |
| GO:BP | GO:0072078 | nephron tubule morphogenesis | 49 | 54 | 9.22e-03 |
| GO:BP | GO:0042475 | odontogenesis of dentin-containing tooth | 49 | 54 | 9.22e-03 |
| GO:BP | GO:0055074 | calcium ion homeostasis | 175 | 216 | 9.37e-03 |
| GO:BP | GO:0030098 | lymphocyte differentiation | 200 | 249 | 9.41e-03 |
| GO:BP | GO:0001659 | temperature homeostasis | 109 | 130 | 9.82e-03 |
| GO:BP | GO:0009612 | response to mechanical stimulus | 126 | 152 | 9.82e-03 |
| GO:BP | GO:0035270 | endocrine system development | 73 | 84 | 9.82e-03 |
| GO:BP | GO:0034764 | positive regulation of transmembrane transport | 109 | 130 | 9.82e-03 |
| GO:BP | GO:0048562 | embryonic organ morphogenesis | 149 | 182 | 9.82e-03 |
| GO:BP | GO:0048546 | digestive tract morphogenesis | 29 | 30 | 9.82e-03 |
| GO:BP | GO:0046850 | regulation of bone remodeling | 29 | 30 | 9.82e-03 |
| GO:BP | GO:0021700 | developmental maturation | 165 | 203 | 9.84e-03 |
| GO:BP | GO:1990845 | adaptive thermogenesis | 102 | 121 | 9.84e-03 |
| GO:BP | GO:0009952 | anterior/posterior pattern specification | 102 | 121 | 9.84e-03 |
| GO:BP | GO:0050867 | positive regulation of cell activation | 165 | 203 | 9.84e-03 |
| GO:BP | GO:0007346 | regulation of mitotic cell cycle | 328 | 420 | 9.87e-03 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | 1376 | 1856 | 9.87e-03 |
| GO:BP | GO:0048259 | regulation of receptor-mediated endocytosis | 69 | 79 | 1.00e-02 |
| GO:BP | GO:0050680 | negative regulation of epithelial cell proliferation | 84 | 98 | 1.00e-02 |
| GO:BP | GO:0030031 | cell projection assembly | 348 | 447 | 1.01e-02 |
| GO:BP | GO:0042110 | T cell activation | 242 | 305 | 1.01e-02 |
| GO:BP | GO:0048644 | muscle organ morphogenesis | 57 | 64 | 1.01e-02 |
| GO:BP | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 44 | 48 | 1.02e-02 |
| GO:BP | GO:0014032 | neural crest cell development | 61 | 69 | 1.02e-02 |
| GO:BP | GO:0001755 | neural crest cell migration | 44 | 48 | 1.02e-02 |
| GO:BP | GO:0071396 | cellular response to lipid | 304 | 388 | 1.04e-02 |
| GO:BP | GO:0060048 | cardiac muscle contraction | 98 | 116 | 1.05e-02 |
| GO:BP | GO:0099173 | postsynapse organization | 122 | 147 | 1.05e-02 |
| GO:BP | GO:0045598 | regulation of fat cell differentiation | 80 | 93 | 1.05e-02 |
| GO:BP | GO:0033043 | regulation of organelle organization | 720 | 953 | 1.07e-02 |
| GO:BP | GO:0032880 | regulation of protein localization | 528 | 691 | 1.08e-02 |
| GO:BP | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 115 | 138 | 1.09e-02 |
| GO:BP | GO:0031641 | regulation of myelination | 34 | 36 | 1.10e-02 |
| GO:BP | GO:0003203 | endocardial cushion morphogenesis | 34 | 36 | 1.10e-02 |
| GO:BP | GO:0048608 | reproductive structure development | 164 | 202 | 1.10e-02 |
| GO:BP | GO:0033036 | macromolecule localization | 1702 | 2309 | 1.10e-02 |
| GO:BP | GO:0006874 | intracellular calcium ion homeostasis | 164 | 202 | 1.10e-02 |
| GO:BP | GO:0003177 | pulmonary valve development | 22 | 22 | 1.11e-02 |
| GO:BP | GO:0060045 | positive regulation of cardiac muscle cell proliferation | 22 | 22 | 1.11e-02 |
| GO:BP | GO:0050921 | positive regulation of chemotaxis | 72 | 83 | 1.15e-02 |
| GO:BP | GO:0050679 | positive regulation of epithelial cell proliferation | 118 | 142 | 1.15e-02 |
| GO:BP | GO:0007611 | learning or memory | 154 | 189 | 1.16e-02 |
| GO:BP | GO:0051235 | maintenance of location | 201 | 251 | 1.16e-02 |
| GO:BP | GO:0006936 | muscle contraction | 204 | 255 | 1.17e-02 |
| GO:BP | GO:0002028 | regulation of sodium ion transport | 52 | 58 | 1.18e-02 |
| GO:BP | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 52 | 58 | 1.18e-02 |
| GO:BP | GO:0021915 | neural tube development | 111 | 133 | 1.18e-02 |
| GO:BP | GO:0045661 | regulation of myoblast differentiation | 52 | 58 | 1.18e-02 |
| GO:BP | GO:0050865 | regulation of cell activation | 273 | 347 | 1.19e-02 |
| GO:BP | GO:0002696 | positive regulation of leukocyte activation | 160 | 197 | 1.21e-02 |
| GO:BP | GO:0120031 | plasma membrane bounded cell projection assembly | 340 | 437 | 1.21e-02 |
| GO:BP | GO:0007492 | endoderm development | 56 | 63 | 1.21e-02 |
| GO:BP | GO:0086001 | cardiac muscle cell action potential | 56 | 63 | 1.21e-02 |
| GO:BP | GO:0032535 | regulation of cellular component size | 228 | 287 | 1.21e-02 |
| GO:BP | GO:0010232 | vascular transport | 60 | 68 | 1.21e-02 |
| GO:BP | GO:0019915 | lipid storage | 60 | 68 | 1.21e-02 |
| GO:BP | GO:0043502 | regulation of muscle adaptation | 60 | 68 | 1.21e-02 |
| GO:BP | GO:0150104 | transport across blood-brain barrier | 60 | 68 | 1.21e-02 |
| GO:BP | GO:0071675 | regulation of mononuclear cell migration | 60 | 68 | 1.21e-02 |
| GO:BP | GO:0150117 | positive regulation of cell-substrate junction organization | 28 | 29 | 1.24e-02 |
| GO:BP | GO:0060563 | neuroepithelial cell differentiation | 28 | 29 | 1.24e-02 |
| GO:BP | GO:1990776 | response to angiotensin | 28 | 29 | 1.24e-02 |
| GO:BP | GO:0002067 | glandular epithelial cell differentiation | 43 | 47 | 1.24e-02 |
| GO:BP | GO:0014743 | regulation of muscle hypertrophy | 43 | 47 | 1.24e-02 |
| GO:BP | GO:0014015 | positive regulation of gliogenesis | 43 | 47 | 1.24e-02 |
| GO:BP | GO:0045860 | positive regulation of protein kinase activity | 150 | 184 | 1.26e-02 |
| GO:BP | GO:0070252 | actin-mediated cell contraction | 75 | 87 | 1.29e-02 |
| GO:BP | GO:0008104 | protein localization | 1478 | 2000 | 1.34e-02 |
| GO:BP | GO:0018193 | peptidyl-amino acid modification | 427 | 555 | 1.34e-02 |
| GO:BP | GO:1905314 | semi-lunar valve development | 38 | 41 | 1.35e-02 |
| GO:BP | GO:0022409 | positive regulation of cell-cell adhesion | 143 | 175 | 1.35e-02 |
| GO:BP | GO:1905330 | regulation of morphogenesis of an epithelium | 38 | 41 | 1.35e-02 |
| GO:BP | GO:0010171 | body morphogenesis | 38 | 41 | 1.35e-02 |
| GO:BP | GO:0001936 | regulation of endothelial cell proliferation | 82 | 96 | 1.37e-02 |
| GO:BP | GO:0070727 | cellular macromolecule localization | 1485 | 2010 | 1.38e-02 |
| GO:BP | GO:0045444 | fat cell differentiation | 146 | 179 | 1.39e-02 |
| GO:BP | GO:0001935 | endothelial cell proliferation | 96 | 114 | 1.40e-02 |
| GO:BP | GO:0051090 | regulation of DNA-binding transcription factor activity | 193 | 241 | 1.40e-02 |
| GO:BP | GO:0051492 | regulation of stress fiber assembly | 67 | 77 | 1.40e-02 |
| GO:BP | GO:0050863 | regulation of T cell activation | 165 | 204 | 1.40e-02 |
| GO:BP | GO:0051046 | regulation of secretion | 309 | 396 | 1.43e-02 |
| GO:BP | GO:1904892 | regulation of receptor signaling pathway via STAT | 51 | 57 | 1.43e-02 |
| GO:BP | GO:0055013 | cardiac muscle cell development | 63 | 72 | 1.43e-02 |
| GO:BP | GO:0014812 | muscle cell migration | 63 | 72 | 1.43e-02 |
| GO:BP | GO:0008589 | regulation of smoothened signaling pathway | 63 | 72 | 1.43e-02 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | 208 | 261 | 1.44e-02 |
| GO:BP | GO:0060384 | innervation | 21 | 21 | 1.45e-02 |
| GO:BP | GO:0042634 | regulation of hair cycle | 21 | 21 | 1.45e-02 |
| GO:BP | GO:0007224 | smoothened signaling pathway | 99 | 118 | 1.50e-02 |
| GO:BP | GO:0035019 | somatic stem cell population maintenance | 42 | 46 | 1.55e-02 |
| GO:BP | GO:0072171 | mesonephric tubule morphogenesis | 42 | 46 | 1.55e-02 |
| GO:BP | GO:0003197 | endocardial cushion development | 42 | 46 | 1.55e-02 |
| GO:BP | GO:0010611 | regulation of cardiac muscle hypertrophy | 42 | 46 | 1.55e-02 |
| GO:BP | GO:0032868 | response to insulin | 164 | 203 | 1.58e-02 |
| GO:BP | GO:0016266 | O-glycan processing | 27 | 28 | 1.60e-02 |
| GO:BP | GO:0048675 | axon extension | 81 | 95 | 1.60e-02 |
| GO:BP | GO:0098739 | import across plasma membrane | 102 | 122 | 1.60e-02 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | 1326 | 1791 | 1.60e-02 |
| GO:BP | GO:0038127 | ERBB signaling pathway | 88 | 104 | 1.64e-02 |
| GO:BP | GO:0072132 | mesenchyme morphogenesis | 46 | 51 | 1.68e-02 |
| GO:BP | GO:0099003 | vesicle-mediated transport in synapse | 138 | 169 | 1.70e-02 |
| GO:BP | GO:0048286 | lung alveolus development | 37 | 40 | 1.71e-02 |
| GO:BP | GO:0002376 | immune system process | 1050 | 1410 | 1.72e-02 |
| GO:BP | GO:0006954 | inflammatory response | 330 | 425 | 1.72e-02 |
| GO:BP | GO:0006915 | apoptotic process | 1026 | 1377 | 1.74e-02 |
| GO:BP | GO:0003229 | ventricular cardiac muscle tissue development | 50 | 56 | 1.75e-02 |
| GO:BP | GO:0062013 | positive regulation of small molecule metabolic process | 84 | 99 | 1.77e-02 |
| GO:BP | GO:0071230 | cellular response to amino acid stimulus | 58 | 66 | 1.77e-02 |
| GO:BP | GO:0060415 | muscle tissue morphogenesis | 54 | 61 | 1.78e-02 |
| GO:BP | GO:1903530 | regulation of secretion by cell | 286 | 366 | 1.81e-02 |
| GO:BP | GO:0048640 | negative regulation of developmental growth | 73 | 85 | 1.82e-02 |
| GO:BP | GO:0031667 | response to nutrient levels | 277 | 354 | 1.85e-02 |
| GO:BP | GO:0051251 | positive regulation of lymphocyte activation | 150 | 185 | 1.87e-02 |
| GO:BP | GO:0001704 | formation of primary germ layer | 80 | 94 | 1.90e-02 |
| GO:BP | GO:0140747 | regulation of ncRNA transcription | 69 | 80 | 1.93e-02 |
| GO:BP | GO:0060675 | ureteric bud morphogenesis | 41 | 45 | 1.94e-02 |
| GO:BP | GO:0090183 | regulation of kidney development | 20 | 20 | 1.96e-02 |
| GO:BP | GO:0002053 | positive regulation of mesenchymal cell proliferation | 20 | 20 | 1.96e-02 |
| GO:BP | GO:0014070 | response to organic cyclic compound | 463 | 606 | 2.10e-02 |
| GO:BP | GO:0090497 | mesenchymal cell migration | 45 | 50 | 2.10e-02 |
| GO:BP | GO:0072210 | metanephric nephron development | 26 | 27 | 2.11e-02 |
| GO:BP | GO:1904385 | cellular response to angiotensin | 26 | 27 | 2.11e-02 |
| GO:BP | GO:0060416 | response to growth hormone | 26 | 27 | 2.11e-02 |
| GO:BP | GO:1904646 | cellular response to amyloid-beta | 26 | 27 | 2.11e-02 |
| GO:BP | GO:0055008 | cardiac muscle tissue morphogenesis | 49 | 55 | 2.16e-02 |
| GO:BP | GO:0046578 | regulation of Ras protein signal transduction | 36 | 39 | 2.16e-02 |
| GO:BP | GO:0021536 | diencephalon development | 36 | 39 | 2.16e-02 |
| GO:BP | GO:0046425 | regulation of receptor signaling pathway via JAK-STAT | 49 | 55 | 2.16e-02 |
| GO:BP | GO:0051983 | regulation of chromosome segregation | 100 | 120 | 2.17e-02 |
| GO:BP | GO:0014909 | smooth muscle cell migration | 53 | 60 | 2.17e-02 |
| GO:BP | GO:0051301 | cell division | 415 | 541 | 2.17e-02 |
| GO:BP | GO:0046683 | response to organophosphorus | 79 | 93 | 2.24e-02 |
| GO:BP | GO:0001508 | action potential | 86 | 102 | 2.26e-02 |
| GO:BP | GO:0050801 | monoatomic ion homeostasis | 315 | 406 | 2.34e-02 |
| GO:BP | GO:0009792 | embryo development ending in birth or egg hatching | 400 | 521 | 2.36e-02 |
| GO:BP | GO:0007548 | sex differentiation | 145 | 179 | 2.36e-02 |
| GO:BP | GO:0030217 | T cell differentiation | 148 | 183 | 2.41e-02 |
| GO:BP | GO:0006638 | neutral lipid metabolic process | 75 | 88 | 2.41e-02 |
| GO:BP | GO:0061387 | regulation of extent of cell growth | 75 | 88 | 2.41e-02 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | 239 | 304 | 2.42e-02 |
| GO:BP | GO:0031644 | regulation of nervous system process | 64 | 74 | 2.42e-02 |
| GO:BP | GO:0051649 | establishment of localization in cell | 1161 | 1566 | 2.42e-02 |
| GO:BP | GO:0014074 | response to purine-containing compound | 89 | 106 | 2.43e-02 |
| GO:BP | GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 82 | 97 | 2.44e-02 |
| GO:BP | GO:0044772 | mitotic cell cycle phase transition | 297 | 382 | 2.48e-02 |
| GO:BP | GO:0035264 | multicellular organism growth | 99 | 119 | 2.51e-02 |
| GO:BP | GO:0035051 | cardiocyte differentiation | 109 | 132 | 2.51e-02 |
| GO:BP | GO:0045685 | regulation of glial cell differentiation | 44 | 49 | 2.57e-02 |
| GO:BP | GO:0046942 | carboxylic acid transport | 163 | 203 | 2.57e-02 |
| GO:BP | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 71 | 83 | 2.57e-02 |
| GO:BP | GO:0086003 | cardiac muscle cell contraction | 56 | 64 | 2.60e-02 |
| GO:BP | GO:0060740 | prostate gland epithelium morphogenesis | 19 | 19 | 2.62e-02 |
| GO:BP | GO:0010878 | cholesterol storage | 19 | 19 | 2.62e-02 |
| GO:BP | GO:0060512 | prostate gland morphogenesis | 19 | 19 | 2.62e-02 |
| GO:BP | GO:0048566 | embryonic digestive tract development | 19 | 19 | 2.62e-02 |
| GO:BP | GO:0071378 | cellular response to growth hormone stimulus | 19 | 19 | 2.62e-02 |
| GO:BP | GO:0003184 | pulmonary valve morphogenesis | 19 | 19 | 2.62e-02 |
| GO:BP | GO:2000027 | regulation of animal organ morphogenesis | 52 | 59 | 2.63e-02 |
| GO:BP | GO:0046503 | glycerolipid catabolic process | 35 | 38 | 2.70e-02 |
| GO:BP | GO:0045668 | negative regulation of osteoblast differentiation | 35 | 38 | 2.70e-02 |
| GO:BP | GO:0002066 | columnar/cuboidal epithelial cell development | 35 | 38 | 2.70e-02 |
| GO:BP | GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | 35 | 38 | 2.70e-02 |
| GO:BP | GO:0050773 | regulation of dendrite development | 67 | 78 | 2.71e-02 |
| GO:BP | GO:0030510 | regulation of BMP signaling pathway | 67 | 78 | 2.71e-02 |
| GO:BP | GO:0009991 | response to extracellular stimulus | 293 | 377 | 2.71e-02 |
| GO:BP | GO:0010092 | specification of animal organ identity | 25 | 26 | 2.72e-02 |
| GO:BP | GO:0000278 | mitotic cell cycle | 577 | 763 | 2.73e-02 |
| GO:BP | GO:0070371 | ERK1 and ERK2 cascade | 156 | 194 | 2.80e-02 |
| GO:BP | GO:0006639 | acylglycerol metabolic process | 74 | 87 | 2.81e-02 |
| GO:BP | GO:0007613 | memory | 74 | 87 | 2.81e-02 |
| GO:BP | GO:0043009 | chordate embryonic development | 389 | 507 | 2.83e-02 |
| GO:BP | GO:0030501 | positive regulation of bone mineralization | 30 | 32 | 2.85e-02 |
| GO:BP | GO:0071604 | transforming growth factor beta production | 30 | 32 | 2.85e-02 |
| GO:BP | GO:0072583 | clathrin-dependent endocytosis | 39 | 43 | 3.00e-02 |
| GO:BP | GO:0072659 | protein localization to plasma membrane | 189 | 238 | 3.02e-02 |
| GO:BP | GO:0044784 | metaphase/anaphase transition of cell cycle | 77 | 91 | 3.08e-02 |
| GO:BP | GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 77 | 91 | 3.08e-02 |
| GO:BP | GO:0006637 | acyl-CoA metabolic process | 55 | 63 | 3.11e-02 |
| GO:BP | GO:0002688 | regulation of leukocyte chemotaxis | 55 | 63 | 3.11e-02 |
| GO:BP | GO:0035383 | thioester metabolic process | 55 | 63 | 3.11e-02 |
| GO:BP | GO:0002694 | regulation of leukocyte activation | 245 | 313 | 3.13e-02 |
| GO:BP | GO:0051058 | negative regulation of small GTPase mediated signal transduction | 43 | 48 | 3.15e-02 |
| GO:BP | GO:0008219 | cell death | 1056 | 1423 | 3.15e-02 |
| GO:BP | GO:0022408 | negative regulation of cell-cell adhesion | 94 | 113 | 3.16e-02 |
| GO:BP | GO:0008543 | fibroblast growth factor receptor signaling pathway | 51 | 58 | 3.17e-02 |
| GO:BP | GO:0033674 | positive regulation of kinase activity | 158 | 197 | 3.17e-02 |
| GO:BP | GO:0048844 | artery morphogenesis | 51 | 58 | 3.17e-02 |
| GO:BP | GO:0012501 | programmed cell death | 1053 | 1419 | 3.20e-02 |
| GO:BP | GO:0032526 | response to retinoic acid | 66 | 77 | 3.20e-02 |
| GO:BP | GO:0033993 | response to lipid | 437 | 573 | 3.31e-02 |
| GO:BP | GO:0099504 | synaptic vesicle cycle | 123 | 151 | 3.37e-02 |
| GO:BP | GO:0003176 | aortic valve development | 34 | 37 | 3.39e-02 |
| GO:BP | GO:0070169 | positive regulation of biomineral tissue development | 34 | 37 | 3.39e-02 |
| GO:BP | GO:1902305 | regulation of sodium ion transmembrane transport | 34 | 37 | 3.39e-02 |
| GO:BP | GO:0009611 | response to wounding | 296 | 382 | 3.43e-02 |
| GO:BP | GO:0016049 | cell growth | 296 | 382 | 3.43e-02 |
| GO:BP | GO:0045926 | negative regulation of growth | 148 | 184 | 3.44e-02 |
| GO:BP | GO:1903169 | regulation of calcium ion transmembrane transport | 90 | 108 | 3.45e-02 |
| GO:BP | GO:0035336 | long-chain fatty-acyl-CoA metabolic process | 18 | 18 | 3.49e-02 |
| GO:BP | GO:0010743 | regulation of macrophage derived foam cell differentiation | 18 | 18 | 3.49e-02 |
| GO:BP | GO:0071880 | adenylate cyclase-activating adrenergic receptor signaling pathway | 18 | 18 | 3.49e-02 |
| GO:BP | GO:0060396 | growth hormone receptor signaling pathway | 18 | 18 | 3.49e-02 |
| GO:BP | GO:0055080 | monoatomic cation homeostasis | 310 | 401 | 3.49e-02 |
| GO:BP | GO:0006909 | phagocytosis | 113 | 138 | 3.49e-02 |
| GO:BP | GO:1902905 | positive regulation of supramolecular fiber organization | 113 | 138 | 3.49e-02 |
| GO:BP | GO:0035025 | positive regulation of Rho protein signal transduction | 24 | 25 | 3.50e-02 |
| GO:BP | GO:0099171 | presynaptic modulation of chemical synaptic transmission | 24 | 25 | 3.50e-02 |
| GO:BP | GO:0060351 | cartilage development involved in endochondral bone morphogenesis | 24 | 25 | 3.50e-02 |
| GO:BP | GO:0007091 | metaphase/anaphase transition of mitotic cell cycle | 76 | 90 | 3.57e-02 |
| GO:BP | GO:0015849 | organic acid transport | 163 | 204 | 3.57e-02 |
| GO:BP | GO:0007219 | Notch signaling pathway | 116 | 142 | 3.58e-02 |
| GO:BP | GO:1902904 | negative regulation of supramolecular fiber organization | 103 | 125 | 3.58e-02 |
| GO:BP | GO:0071634 | regulation of transforming growth factor beta production | 29 | 31 | 3.59e-02 |
| GO:BP | GO:0045687 | positive regulation of glial cell differentiation | 29 | 31 | 3.59e-02 |
| GO:BP | GO:0030857 | negative regulation of epithelial cell differentiation | 29 | 31 | 3.59e-02 |
| GO:BP | GO:1904645 | response to amyloid-beta | 29 | 31 | 3.59e-02 |
| GO:BP | GO:0060688 | regulation of morphogenesis of a branching structure | 29 | 31 | 3.59e-02 |
| GO:BP | GO:0106106 | cold-induced thermogenesis | 93 | 112 | 3.59e-02 |
| GO:BP | GO:0019058 | viral life cycle | 184 | 232 | 3.64e-02 |
| GO:BP | GO:0051591 | response to cAMP | 54 | 62 | 3.68e-02 |
| GO:BP | GO:0070372 | regulation of ERK1 and ERK2 cascade | 141 | 175 | 3.71e-02 |
| GO:BP | GO:0030705 | cytoskeleton-dependent intracellular transport | 144 | 179 | 3.77e-02 |
| GO:BP | GO:0051899 | membrane depolarization | 50 | 57 | 3.78e-02 |
| GO:BP | GO:0097009 | energy homeostasis | 50 | 57 | 3.78e-02 |
| GO:BP | GO:0032147 | activation of protein kinase activity | 50 | 57 | 3.78e-02 |
| GO:BP | GO:0033555 | multicellular organismal response to stress | 50 | 57 | 3.78e-02 |
| GO:BP | GO:0009953 | dorsal/ventral pattern formation | 42 | 47 | 3.79e-02 |
| GO:BP | GO:0051653 | spindle localization | 46 | 52 | 3.82e-02 |
| GO:BP | GO:0001708 | cell fate specification | 46 | 52 | 3.82e-02 |
| GO:BP | GO:0048863 | stem cell differentiation | 153 | 191 | 3.87e-02 |
| GO:BP | GO:0006629 | lipid metabolic process | 692 | 923 | 3.92e-02 |
| GO:BP | GO:0033045 | regulation of sister chromatid segregation | 82 | 98 | 4.09e-02 |
| GO:BP | GO:0120161 | regulation of cold-induced thermogenesis | 92 | 111 | 4.16e-02 |
| GO:BP | GO:0048813 | dendrite morphogenesis | 92 | 111 | 4.16e-02 |
| GO:BP | GO:0010876 | lipid localization | 233 | 298 | 4.16e-02 |
| GO:BP | GO:0051495 | positive regulation of cytoskeleton organization | 118 | 145 | 4.17e-02 |
| GO:BP | GO:0038179 | neurotrophin signaling pathway | 33 | 36 | 4.19e-02 |
| GO:BP | GO:0044272 | sulfur compound biosynthetic process | 105 | 128 | 4.24e-02 |
| GO:BP | GO:1903708 | positive regulation of hemopoiesis | 95 | 115 | 4.35e-02 |
| GO:BP | GO:1902107 | positive regulation of leukocyte differentiation | 95 | 115 | 4.35e-02 |
| GO:BP | GO:0046649 | lymphocyte activation | 341 | 444 | 4.38e-02 |
| GO:BP | GO:0035567 | non-canonical Wnt signaling pathway | 53 | 61 | 4.43e-02 |
| GO:BP | GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels | 53 | 61 | 4.43e-02 |
| GO:BP | GO:0042303 | molting cycle | 64 | 75 | 4.44e-02 |
| GO:BP | GO:0042633 | hair cycle | 64 | 75 | 4.44e-02 |
| GO:BP | GO:0045453 | bone resorption | 37 | 41 | 4.48e-02 |
| GO:BP | GO:0048872 | homeostasis of number of cells | 176 | 222 | 4.48e-02 |
| GO:BP | GO:0021952 | central nervous system projection neuron axonogenesis | 23 | 24 | 4.48e-02 |
| GO:BP | GO:0022029 | telencephalon cell migration | 37 | 41 | 4.48e-02 |
| GO:BP | GO:0010812 | negative regulation of cell-substrate adhesion | 37 | 41 | 4.48e-02 |
| GO:BP | GO:0003272 | endocardial cushion formation | 23 | 24 | 4.48e-02 |
| GO:BP | GO:0051894 | positive regulation of focal adhesion assembly | 23 | 24 | 4.48e-02 |
| GO:BP | GO:0061383 | trabecula morphogenesis | 37 | 41 | 4.48e-02 |
| GO:BP | GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction | 170 | 214 | 4.48e-02 |
| GO:BP | GO:0045124 | regulation of bone resorption | 23 | 24 | 4.48e-02 |
| GO:BP | GO:0051146 | striated muscle cell differentiation | 185 | 234 | 4.48e-02 |
| GO:BP | GO:2000737 | negative regulation of stem cell differentiation | 23 | 24 | 4.48e-02 |
| GO:BP | GO:0050919 | negative chemotaxis | 37 | 41 | 4.48e-02 |
| GO:BP | GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 23 | 24 | 4.48e-02 |
| GO:BP | GO:0046661 | male sex differentiation | 88 | 106 | 4.50e-02 |
| GO:BP | GO:0001937 | negative regulation of endothelial cell proliferation | 28 | 30 | 4.50e-02 |
| GO:BP | GO:0060914 | heart formation | 28 | 30 | 4.50e-02 |
| GO:BP | GO:0001974 | blood vessel remodeling | 28 | 30 | 4.50e-02 |
| GO:BP | GO:0060323 | head morphogenesis | 28 | 30 | 4.50e-02 |
| GO:BP | GO:1901990 | regulation of mitotic cell cycle phase transition | 229 | 293 | 4.51e-02 |
| GO:BP | GO:0016032 | viral process | 255 | 328 | 4.53e-02 |
| GO:BP | GO:0034505 | tooth mineralization | 17 | 17 | 4.53e-02 |
| GO:BP | GO:0009065 | glutamine family amino acid catabolic process | 17 | 17 | 4.53e-02 |
| GO:BP | GO:0003215 | cardiac right ventricle morphogenesis | 17 | 17 | 4.53e-02 |
| GO:BP | GO:0032528 | microvillus organization | 17 | 17 | 4.53e-02 |
| GO:BP | GO:0060977 | coronary vasculature morphogenesis | 17 | 17 | 4.53e-02 |
| GO:BP | GO:0050771 | negative regulation of axonogenesis | 45 | 51 | 4.57e-02 |
| GO:BP | GO:0006865 | amino acid transport | 81 | 97 | 4.64e-02 |
| GO:BP | GO:0006470 | protein dephosphorylation | 142 | 177 | 4.64e-02 |
| GO:BP | GO:0070482 | response to oxygen levels | 208 | 265 | 4.71e-02 |
| GO:BP | GO:0006869 | lipid transport | 205 | 261 | 4.73e-02 |
| GO:BP | GO:0051494 | negative regulation of cytoskeleton organization | 104 | 127 | 4.74e-02 |
| GO:BP | GO:0008593 | regulation of Notch signaling pathway | 67 | 79 | 4.76e-02 |
| GO:BP | GO:0035303 | regulation of dephosphorylation | 67 | 79 | 4.76e-02 |
| GO:BP | GO:0002573 | myeloid leukocyte differentiation | 123 | 152 | 4.81e-02 |
| GO:BP | GO:0006887 | exocytosis | 187 | 237 | 4.84e-02 |
| GO:BP | GO:0001942 | hair follicle development | 56 | 65 | 4.93e-02 |
LRnomtable %>%
filter(source=="KEGG", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in LR neargenes") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:05200 | Pathways in cancer | 328 | 391 | 3.55e-07 |
| KEGG | KEGG:04360 | Axon guidance | 137 | 155 | 2.59e-05 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 142 | 162 | 3.40e-05 |
| KEGG | KEGG:04971 | Gastric acid secretion | 50 | 51 | 4.56e-05 |
| KEGG | KEGG:04310 | Wnt signaling pathway | 118 | 133 | 4.79e-05 |
| KEGG | KEGG:04024 | cAMP signaling pathway | 129 | 147 | 5.16e-05 |
| KEGG | KEGG:04510 | Focal adhesion | 146 | 169 | 7.29e-05 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | 140 | 162 | 8.94e-05 |
| KEGG | KEGG:04970 | Salivary secretion | 52 | 54 | 8.94e-05 |
| KEGG | KEGG:04014 | Ras signaling pathway | 141 | 164 | 1.28e-04 |
| KEGG | KEGG:04520 | Adherens junction | 76 | 83 | 1.28e-04 |
| KEGG | KEGG:04022 | cGMP-PKG signaling pathway | 113 | 129 | 1.52e-04 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | 90 | 101 | 2.61e-04 |
| KEGG | KEGG:04611 | Platelet activation | 79 | 88 | 4.18e-04 |
| KEGG | KEGG:04020 | Calcium signaling pathway | 137 | 161 | 4.18e-04 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | 143 | 169 | 4.86e-04 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | 135 | 160 | 9.35e-04 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 70 | 78 | 9.35e-04 |
| KEGG | KEGG:04924 | Renin secretion | 47 | 50 | 9.35e-04 |
| KEGG | KEGG:04911 | Insulin secretion | 57 | 62 | 9.35e-04 |
| KEGG | KEGG:05146 | Amoebiasis | 57 | 62 | 9.35e-04 |
| KEGG | KEGG:04512 | ECM-receptor interaction | 60 | 66 | 1.17e-03 |
| KEGG | KEGG:04270 | Vascular smooth muscle contraction | 81 | 92 | 1.17e-03 |
| KEGG | KEGG:04010 | MAPK signaling pathway | 189 | 231 | 1.24e-03 |
| KEGG | KEGG:04925 | Aldosterone synthesis and secretion | 67 | 75 | 1.55e-03 |
| KEGG | KEGG:04916 | Melanogenesis | 67 | 75 | 1.55e-03 |
| KEGG | KEGG:04918 | Thyroid hormone synthesis | 49 | 53 | 1.59e-03 |
| KEGG | KEGG:04927 | Cortisol synthesis and secretion | 43 | 46 | 2.09e-03 |
| KEGG | KEGG:04972 | Pancreatic secretion | 52 | 57 | 2.29e-03 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | 202 | 250 | 2.43e-03 |
| KEGG | KEGG:04148 | Efferocytosis | 102 | 120 | 2.50e-03 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | 76 | 87 | 2.50e-03 |
| KEGG | KEGG:04390 | Hippo signaling pathway | 109 | 129 | 2.50e-03 |
| KEGG | KEGG:04974 | Protein digestion and absorption | 51 | 56 | 2.53e-03 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | 105 | 124 | 2.57e-03 |
| KEGG | KEGG:05165 | Human papillomavirus infection | 202 | 252 | 4.72e-03 |
| KEGG | KEGG:04728 | Dopaminergic synapse | 83 | 97 | 5.30e-03 |
| KEGG | KEGG:04713 | Circadian entrainment | 60 | 68 | 5.44e-03 |
| KEGG | KEGG:04976 | Bile secretion | 38 | 41 | 6.05e-03 |
| KEGG | KEGG:04750 | Inflammatory mediator regulation of TRP channels | 63 | 72 | 6.33e-03 |
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | 59 | 67 | 6.33e-03 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | 85 | 100 | 6.37e-03 |
| KEGG | KEGG:04961 | Endocrine and other factor-regulated calcium reabsorption | 37 | 40 | 7.11e-03 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | 77 | 90 | 7.11e-03 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | 118 | 143 | 7.35e-03 |
| KEGG | KEGG:04658 | Th1 and Th2 cell differentiation | 45 | 50 | 8.33e-03 |
| KEGG | KEGG:04072 | Phospholipase D signaling pathway | 90 | 107 | 8.33e-03 |
| KEGG | KEGG:04730 | Long-term depression | 36 | 39 | 8.49e-03 |
| KEGG | KEGG:04630 | JAK-STAT signaling pathway | 71 | 83 | 1.00e-02 |
| KEGG | KEGG:04340 | Hedgehog signaling pathway | 44 | 49 | 1.00e-02 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | 81 | 96 | 1.09e-02 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | 88 | 105 | 1.09e-02 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | 91 | 109 | 1.13e-02 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | 70 | 82 | 1.13e-02 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | 110 | 134 | 1.28e-02 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | 76 | 90 | 1.34e-02 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | 65 | 76 | 1.41e-02 |
| KEGG | KEGG:05135 | Yersinia infection | 89 | 107 | 1.46e-02 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | 108 | 132 | 1.63e-02 |
| KEGG | KEGG:04659 | Th17 cell differentiation | 52 | 60 | 2.00e-02 |
| KEGG | KEGG:04514 | Cell adhesion molecules | 59 | 69 | 2.11e-02 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | 93 | 113 | 2.12e-02 |
| KEGG | KEGG:04371 | Apelin signaling pathway | 86 | 104 | 2.23e-02 |
| KEGG | KEGG:04725 | Cholinergic synapse | 69 | 82 | 2.25e-02 |
| KEGG | KEGG:04071 | Sphingolipid signaling pathway | 85 | 103 | 2.51e-02 |
| KEGG | KEGG:00000 | KEGG root term | 3931 | 5451 | 2.51e-02 |
| KEGG | KEGG:05210 | Colorectal cancer | 68 | 81 | 2.57e-02 |
| KEGG | KEGG:04726 | Serotonergic synapse | 50 | 58 | 2.69e-02 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | 70 | 84 | 3.20e-02 |
| KEGG | KEGG:00512 | Mucin type O-glycan biosynthesis | 20 | 21 | 3.56e-02 |
| KEGG | KEGG:03320 | PPAR signaling pathway | 41 | 47 | 3.59e-02 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | 62 | 74 | 3.77e-02 |
| KEGG | KEGG:04724 | Glutamatergic synapse | 62 | 74 | 3.77e-02 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | 119 | 149 | 3.95e-02 |
| KEGG | KEGG:04720 | Long-term potentiation | 44 | 51 | 3.96e-02 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | 115 | 144 | 4.31e-02 |
| KEGG | KEGG:04923 | Regulation of lipolysis in adipocytes | 36 | 41 | 4.31e-02 |
| KEGG | KEGG:04742 | Taste transduction | 19 | 20 | 4.32e-02 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | 64 | 77 | 4.43e-02 |
| KEGG | KEGG:04934 | Cushing syndrome | 96 | 119 | 4.45e-02 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | 114 | 143 | 4.67e-02 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | 60 | 72 | 4.78e-02 |
| KEGG | KEGG:05032 | Morphine addiction | 46 | 54 | 4.96e-02 |
LRnomtable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
slice_head(n=10) %>%
mutate(log10_p=(-log(p_value, base=10))) %>%
ggplot(., aes(x=log10_p, y=reorder(term_name, log10_p)))+
geom_col(fill="#00BFC4")+
theme_bw()+
ylab("")+
xlab(paste0("-log10 p-value"))+
guides(fill="none")
NR response genes
# NR_resgenes <- gost(query = NR_NG_list$ENTREZID,
# organism = "hsapiens",
# significant = FALSE,
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = background_df$ENTREZID,
# sources=c("GO:BP","KEGG"))
# saveRDS(NR_resgenes,"data/GO_KEGG_analysis/NR_resgenes.RDS")
NRnom <- gostplot(NR_resgenes, capped = FALSE, interactive = TRUE)
# NRnom
NRnomtable <- NR_resgenes$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
NRnomtable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in NR neargenes" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0007275 | multicellular organism development | 3082 | 3170 | 4.30e-05 |
| GO:BP | GO:0032501 | multicellular organismal process | 4362 | 4504 | 4.30e-05 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 3446 | 3550 | 4.40e-05 |
| GO:BP | GO:0051716 | cellular response to stimulus | 4491 | 4640 | 4.44e-05 |
| GO:BP | GO:0007010 | cytoskeleton organization | 1127 | 1146 | 7.38e-05 |
| GO:BP | GO:0048731 | system development | 2645 | 2719 | 7.49e-05 |
| GO:BP | GO:0048856 | anatomical structure development | 3748 | 3867 | 7.49e-05 |
| GO:BP | GO:0050896 | response to stimulus | 5196 | 5379 | 8.02e-05 |
| GO:BP | GO:0050794 | regulation of cellular process | 6888 | 7153 | 2.38e-04 |
| GO:BP | GO:0065007 | biological regulation | 7441 | 7734 | 3.22e-04 |
| GO:BP | GO:0007154 | cell communication | 3855 | 3983 | 3.67e-04 |
| GO:BP | GO:0048519 | negative regulation of biological process | 3645 | 3764 | 3.67e-04 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 1799 | 1844 | 3.67e-04 |
| GO:BP | GO:0050789 | regulation of biological process | 7232 | 7516 | 3.99e-04 |
| GO:BP | GO:0023052 | signaling | 3792 | 3918 | 4.48e-04 |
| GO:BP | GO:0032502 | developmental process | 4042 | 4179 | 4.62e-04 |
| GO:BP | GO:0008150 | biological_process | 10770 | 11244 | 6.46e-04 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 1815 | 1862 | 6.81e-04 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 1016 | 1035 | 6.93e-04 |
| GO:BP | GO:0050793 | regulation of developmental process | 1655 | 1697 | 1.16e-03 |
| GO:BP | GO:0007165 | signal transduction | 3495 | 3611 | 1.16e-03 |
| GO:BP | GO:0023051 | regulation of signaling | 2368 | 2438 | 1.48e-03 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 2636 | 2717 | 1.58e-03 |
| GO:BP | GO:0009966 | regulation of signal transduction | 2106 | 2166 | 1.65e-03 |
| GO:BP | GO:0007399 | nervous system development | 1729 | 1775 | 2.13e-03 |
| GO:BP | GO:0016477 | cell migration | 991 | 1011 | 2.73e-03 |
| GO:BP | GO:0022008 | neurogenesis | 1223 | 1251 | 2.76e-03 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | 601 | 609 | 2.83e-03 |
| GO:BP | GO:0000902 | cell morphogenesis | 702 | 713 | 2.92e-03 |
| GO:BP | GO:0010646 | regulation of cell communication | 2372 | 2444 | 2.95e-03 |
| GO:BP | GO:0030029 | actin filament-based process | 631 | 640 | 3.04e-03 |
| GO:BP | GO:0048518 | positive regulation of biological process | 4153 | 4301 | 3.42e-03 |
| GO:BP | GO:0009888 | tissue development | 1316 | 1348 | 3.77e-03 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 3820 | 3954 | 4.19e-03 |
| GO:BP | GO:0048699 | generation of neurons | 1053 | 1076 | 4.37e-03 |
| GO:BP | GO:0007155 | cell adhesion | 922 | 941 | 6.18e-03 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | 821 | 837 | 8.05e-03 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 1169 | 1197 | 8.05e-03 |
| GO:BP | GO:0016043 | cellular component organization | 4630 | 4802 | 8.05e-03 |
| GO:BP | GO:0009987 | cellular process | 10236 | 10686 | 8.78e-03 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | 558 | 566 | 8.78e-03 |
| GO:BP | GO:0030182 | neuron differentiation | 992 | 1014 | 8.85e-03 |
| GO:BP | GO:0048513 | animal organ development | 1946 | 2004 | 1.02e-02 |
| GO:BP | GO:0065008 | regulation of biological quality | 1839 | 1893 | 1.13e-02 |
| GO:BP | GO:0035295 | tube development | 772 | 787 | 1.14e-02 |
| GO:BP | GO:0048870 | cell motility | 1094 | 1120 | 1.14e-02 |
| GO:BP | GO:0048869 | cellular developmental process | 2714 | 2804 | 1.27e-02 |
| GO:BP | GO:0030154 | cell differentiation | 2713 | 2803 | 1.27e-02 |
| GO:BP | GO:0007267 | cell-cell signaling | 1057 | 1082 | 1.32e-02 |
| GO:BP | GO:0007015 | actin filament organization | 354 | 357 | 1.44e-02 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 1868 | 1924 | 1.54e-02 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | 260 | 261 | 1.76e-02 |
| GO:BP | GO:0048468 | cell development | 1831 | 1886 | 1.89e-02 |
| GO:BP | GO:0031589 | cell-substrate adhesion | 257 | 258 | 1.90e-02 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | 1067 | 1093 | 1.90e-02 |
| GO:BP | GO:0097435 | supramolecular fiber organization | 622 | 633 | 2.02e-02 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | 298 | 300 | 2.24e-02 |
| GO:BP | GO:0035556 | intracellular signal transduction | 1893 | 1951 | 2.27e-02 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | 578 | 588 | 2.81e-02 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 4802 | 4988 | 4.57e-02 |
| GO:BP | GO:0023056 | positive regulation of signaling | 1189 | 1221 | 4.59e-02 |
| GO:BP | GO:0006996 | organelle organization | 2721 | 2815 | 4.63e-02 |
| GO:BP | GO:0010647 | positive regulation of cell communication | 1186 | 1218 | 4.77e-02 |
NRnomtable %>%
filter(source=="KEGG", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in NR neargenes") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA |
| :—— | :——- | :——— | —————–: | ———: | :——- |
Peaks within 20,000 bps of assigned nearest expressed gene, GO and KEGG enrichment
# exp_neargene_table <- read_delim("data/n45_bedfiles/exp_neargene_table.tsv",
# delim = "\t", escape_double = FALSE,
# trim_ws = TRUE)
# col_ng_peak <- exp_neargene_table %>%
# group_by(chr, start, end, peakid) %>%
# summarise(NCBI_gene = paste(unique(ENTREZID),collapse=","),
# ensembl_ID= paste(unique(ensembl_id),collapse = ","),
# SYMBOL= paste(unique(SYMBOL),collapse = ",") ,
# dist_to_NG =min(dist_to_NG)) %>%
# ungroup()
# write.csv(col_ng_peak, "data/Collapsed_expressed_NG_peak_table.csv")
col_ng_peak <- read.csv("data/Collapsed_expressed_NG_peak_table.csv", row.names = 1)
EAR_peak_list_20k <- col_ng_peak %>%
dplyr::filter(dist_to_NG<20000) %>%
dplyr::filter(peakid %in% EAR_df$id)
ESR_peak_list_20k <- col_ng_peak %>%
dplyr::filter(dist_to_NG<20000) %>%
dplyr::filter(peakid %in% ESR_df$id)
LR_peak_list_20k <- col_ng_peak %>%
dplyr::filter(dist_to_NG<20000) %>%
dplyr::filter(peakid %in% LR_df$id)
NR_peak_list_20k <- col_ng_peak %>%
dplyr::filter(dist_to_NG<20000) %>%
dplyr::filter(peakid %in% NR_df$id) EAR 20,000 bp NG
# EAR_resgenes_20k <- gost(query = EAR_peak_list_20k$ENTREZID,
# organism = "hsapiens",
# significant = FALSE,
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = background_df$ENTREZID,
# sources=c("GO:BP","KEGG"))
# saveRDS(EAR_resgenes_20k,"data/GO_KEGG_analysis/EAR_resgenes_20k.RDS")
EARnom <- gostplot(EAR_resgenes_20k, capped = FALSE, interactive = TRUE)
# EARnom
EARnomtable_20k <- EAR_resgenes_20k$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
EARnomtable_20k %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in EAR neargenes_20k" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 700 | 1844 | 9.84e-20 |
| GO:BP | GO:0048856 | anatomical structure development | 1307 | 3867 | 8.91e-18 |
| GO:BP | GO:0032502 | developmental process | 1397 | 4179 | 1.19e-17 |
| GO:BP | GO:0032501 | multicellular organismal process | 1481 | 4504 | 5.39e-16 |
| GO:BP | GO:0007275 | multicellular organism development | 1086 | 3170 | 8.40e-16 |
| GO:BP | GO:0048731 | system development | 948 | 2719 | 1.49e-15 |
| GO:BP | GO:0048869 | cellular developmental process | 972 | 2804 | 2.68e-15 |
| GO:BP | GO:0050793 | regulation of developmental process | 629 | 1697 | 2.85e-15 |
| GO:BP | GO:0030154 | cell differentiation | 971 | 2803 | 2.85e-15 |
| GO:BP | GO:0050789 | regulation of biological process | 2316 | 7516 | 1.46e-14 |
| GO:BP | GO:0065007 | biological regulation | 2368 | 7734 | 1.72e-13 |
| GO:BP | GO:0050794 | regulation of cellular process | 2207 | 7153 | 3.23e-13 |
| GO:BP | GO:0023052 | signaling | 1286 | 3918 | 9.00e-13 |
| GO:BP | GO:0007154 | cell communication | 1304 | 3983 | 1.18e-12 |
| GO:BP | GO:0048699 | generation of neurons | 414 | 1076 | 4.57e-12 |
| GO:BP | GO:0022008 | neurogenesis | 469 | 1251 | 9.52e-12 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 680 | 1924 | 1.19e-11 |
| GO:BP | GO:0007165 | signal transduction | 1187 | 3611 | 1.30e-11 |
| GO:BP | GO:0072359 | circulatory system development | 340 | 864 | 3.97e-11 |
| GO:BP | GO:0016477 | cell migration | 387 | 1011 | 7.21e-11 |
| GO:BP | GO:0030182 | neuron differentiation | 387 | 1014 | 1.13e-10 |
| GO:BP | GO:0048468 | cell development | 658 | 1886 | 5.47e-10 |
| GO:BP | GO:0048519 | negative regulation of biological process | 1219 | 3764 | 6.07e-10 |
| GO:BP | GO:0050896 | response to stimulus | 1681 | 5379 | 1.37e-09 |
| GO:BP | GO:0007399 | nervous system development | 621 | 1775 | 1.42e-09 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 1153 | 3550 | 1.49e-09 |
| GO:BP | GO:0048870 | cell motility | 415 | 1120 | 1.76e-09 |
| GO:BP | GO:0051716 | cellular response to stimulus | 1468 | 4640 | 2.02e-09 |
| GO:BP | GO:2000145 | regulation of cell motility | 277 | 700 | 3.21e-09 |
| GO:BP | GO:0030334 | regulation of cell migration | 266 | 668 | 3.76e-09 |
| GO:BP | GO:0048666 | neuron development | 322 | 838 | 3.90e-09 |
| GO:BP | GO:0141124 | intracellular signaling cassette | 474 | 1314 | 4.50e-09 |
| GO:BP | GO:0010975 | regulation of neuron projection development | 158 | 355 | 4.59e-09 |
| GO:BP | GO:0034330 | cell junction organization | 224 | 545 | 4.64e-09 |
| GO:BP | GO:0048513 | animal organ development | 687 | 2004 | 4.83e-09 |
| GO:BP | GO:0040012 | regulation of locomotion | 282 | 720 | 6.38e-09 |
| GO:BP | GO:0030029 | actin filament-based process | 255 | 640 | 7.81e-09 |
| GO:BP | GO:0031344 | regulation of cell projection organization | 213 | 516 | 7.92e-09 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 642 | 1862 | 7.92e-09 |
| GO:BP | GO:0031175 | neuron projection development | 289 | 743 | 7.92e-09 |
| GO:BP | GO:0120035 | regulation of plasma membrane bounded cell projection organization | 209 | 505 | 9.01e-09 |
| GO:BP | GO:0035556 | intracellular signal transduction | 668 | 1951 | 1.11e-08 |
| GO:BP | GO:0000902 | cell morphogenesis | 278 | 713 | 1.33e-08 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | 243 | 609 | 1.67e-08 |
| GO:BP | GO:0048518 | positive regulation of biological process | 1360 | 4301 | 2.23e-08 |
| GO:BP | GO:0040011 | locomotion | 307 | 805 | 2.26e-08 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 1257 | 3954 | 4.34e-08 |
| GO:BP | GO:0010646 | regulation of cell communication | 809 | 2444 | 1.24e-07 |
| GO:BP | GO:0007155 | cell adhesion | 347 | 941 | 1.33e-07 |
| GO:BP | GO:0009887 | animal organ morphogenesis | 260 | 673 | 1.46e-07 |
| GO:BP | GO:0051094 | positive regulation of developmental process | 337 | 913 | 2.04e-07 |
| GO:BP | GO:0065008 | regulation of biological quality | 641 | 1893 | 2.19e-07 |
| GO:BP | GO:0023051 | regulation of signaling | 804 | 2438 | 2.96e-07 |
| GO:BP | GO:0007507 | heart development | 199 | 499 | 8.15e-07 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | 308 | 837 | 1.51e-06 |
| GO:BP | GO:0009966 | regulation of signal transduction | 717 | 2166 | 1.51e-06 |
| GO:BP | GO:0003008 | system process | 403 | 1139 | 1.73e-06 |
| GO:BP | GO:0022604 | regulation of cell morphogenesis | 91 | 193 | 1.94e-06 |
| GO:BP | GO:0009888 | tissue development | 467 | 1348 | 2.31e-06 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | 343 | 951 | 2.39e-06 |
| GO:BP | GO:0045595 | regulation of cell differentiation | 381 | 1073 | 2.73e-06 |
| GO:BP | GO:0009790 | embryo development | 301 | 821 | 3.13e-06 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | 218 | 566 | 3.95e-06 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 368 | 1035 | 3.99e-06 |
| GO:BP | GO:0048812 | neuron projection morphogenesis | 189 | 479 | 4.32e-06 |
| GO:BP | GO:0035239 | tube morphogenesis | 241 | 638 | 4.86e-06 |
| GO:BP | GO:0016358 | dendrite development | 86 | 183 | 5.11e-06 |
| GO:BP | GO:0030030 | cell projection organization | 413 | 1182 | 5.18e-06 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | 403 | 1150 | 5.21e-06 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | 224 | 588 | 6.50e-06 |
| GO:BP | GO:0120039 | plasma membrane bounded cell projection morphogenesis | 193 | 494 | 6.72e-06 |
| GO:BP | GO:0007423 | sensory organ development | 157 | 387 | 7.32e-06 |
| GO:BP | GO:0007264 | small GTPase-mediated signal transduction | 158 | 390 | 7.32e-06 |
| GO:BP | GO:0048858 | cell projection morphogenesis | 194 | 498 | 7.66e-06 |
| GO:BP | GO:0070848 | response to growth factor | 210 | 547 | 8.12e-06 |
| GO:BP | GO:0008360 | regulation of cell shape | 56 | 106 | 8.39e-06 |
| GO:BP | GO:0035295 | tube development | 287 | 787 | 9.83e-06 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | 203 | 528 | 1.15e-05 |
| GO:BP | GO:0048589 | developmental growth | 194 | 501 | 1.21e-05 |
| GO:BP | GO:0016043 | cellular component organization | 1474 | 4802 | 1.71e-05 |
| GO:BP | GO:0001568 | blood vessel development | 201 | 525 | 1.85e-05 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 1525 | 4988 | 2.56e-05 |
| GO:BP | GO:0001944 | vasculature development | 209 | 552 | 2.69e-05 |
| GO:BP | GO:0001501 | skeletal system development | 141 | 347 | 2.70e-05 |
| GO:BP | GO:0009987 | cellular process | 3085 | 10686 | 4.60e-05 |
| GO:BP | GO:0048514 | blood vessel morphogenesis | 174 | 450 | 5.74e-05 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | 302 | 850 | 6.39e-05 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 409 | 1197 | 8.00e-05 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | 272 | 757 | 8.20e-05 |
| GO:BP | GO:0007417 | central nervous system development | 252 | 694 | 8.20e-05 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 863 | 2717 | 9.18e-05 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | 259 | 717 | 9.18e-05 |
| GO:BP | GO:0048667 | cell morphogenesis involved in neuron differentiation | 168 | 435 | 9.18e-05 |
| GO:BP | GO:0001525 | angiogenesis | 150 | 381 | 9.59e-05 |
| GO:BP | GO:0001654 | eye development | 110 | 263 | 9.84e-05 |
| GO:BP | GO:0048880 | sensory system development | 111 | 266 | 9.95e-05 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | 591 | 1801 | 9.97e-05 |
| GO:BP | GO:0030900 | forebrain development | 113 | 272 | 1.02e-04 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | 436 | 1289 | 1.04e-04 |
| GO:BP | GO:0050808 | synapse organization | 135 | 337 | 1.05e-04 |
| GO:BP | GO:0001764 | neuron migration | 62 | 129 | 1.05e-04 |
| GO:BP | GO:0150063 | visual system development | 110 | 264 | 1.14e-04 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | 218 | 591 | 1.14e-04 |
| GO:BP | GO:0034329 | cell junction assembly | 130 | 323 | 1.19e-04 |
| GO:BP | GO:0060322 | head development | 201 | 539 | 1.26e-04 |
| GO:BP | GO:0014706 | striated muscle tissue development | 92 | 213 | 1.31e-04 |
| GO:BP | GO:0051056 | regulation of small GTPase mediated signal transduction | 99 | 233 | 1.31e-04 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | 87 | 201 | 2.24e-04 |
| GO:BP | GO:0040007 | growth | 250 | 697 | 2.25e-04 |
| GO:BP | GO:0043010 | camera-type eye development | 97 | 230 | 2.40e-04 |
| GO:BP | GO:0007267 | cell-cell signaling | 369 | 1082 | 2.92e-04 |
| GO:BP | GO:0061061 | muscle structure development | 198 | 536 | 2.94e-04 |
| GO:BP | GO:0031589 | cell-substrate adhesion | 106 | 258 | 3.48e-04 |
| GO:BP | GO:0051093 | negative regulation of developmental process | 225 | 622 | 3.54e-04 |
| GO:BP | GO:0060537 | muscle tissue development | 133 | 339 | 3.96e-04 |
| GO:BP | GO:0007420 | brain development | 185 | 498 | 3.96e-04 |
| GO:BP | GO:0043408 | regulation of MAPK cascade | 162 | 427 | 3.96e-04 |
| GO:BP | GO:0008150 | biological_process | 3221 | 11244 | 4.26e-04 |
| GO:BP | GO:0031346 | positive regulation of cell projection organization | 115 | 286 | 4.46e-04 |
| GO:BP | GO:0048598 | embryonic morphogenesis | 160 | 422 | 4.55e-04 |
| GO:BP | GO:0044057 | regulation of system process | 147 | 384 | 5.96e-04 |
| GO:BP | GO:0007010 | cytoskeleton organization | 386 | 1146 | 5.99e-04 |
| GO:BP | GO:0060284 | regulation of cell development | 207 | 570 | 5.99e-04 |
| GO:BP | GO:0007015 | actin filament organization | 138 | 357 | 6.17e-04 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | 119 | 300 | 6.28e-04 |
| GO:BP | GO:0042221 | response to chemical | 732 | 2304 | 6.28e-04 |
| GO:BP | GO:0021795 | cerebral cortex cell migration | 22 | 34 | 7.57e-04 |
| GO:BP | GO:0030335 | positive regulation of cell migration | 150 | 395 | 7.57e-04 |
| GO:BP | GO:0006468 | protein phosphorylation | 327 | 958 | 8.77e-04 |
| GO:BP | GO:0031345 | negative regulation of cell projection organization | 65 | 145 | 8.77e-04 |
| GO:BP | GO:0048588 | developmental cell growth | 77 | 179 | 9.05e-04 |
| GO:BP | GO:0099536 | synaptic signaling | 178 | 483 | 9.22e-04 |
| GO:BP | GO:0050773 | regulation of dendrite development | 40 | 78 | 9.33e-04 |
| GO:BP | GO:0060041 | retina development in camera-type eye | 50 | 105 | 1.18e-03 |
| GO:BP | GO:0097435 | supramolecular fiber organization | 225 | 633 | 1.19e-03 |
| GO:BP | GO:0051173 | positive regulation of nitrogen compound metabolic process | 694 | 2186 | 1.21e-03 |
| GO:BP | GO:2000147 | positive regulation of cell motility | 153 | 408 | 1.27e-03 |
| GO:BP | GO:0048813 | dendrite morphogenesis | 52 | 111 | 1.39e-03 |
| GO:BP | GO:0050767 | regulation of neurogenesis | 114 | 290 | 1.42e-03 |
| GO:BP | GO:0086003 | cardiac muscle cell contraction | 34 | 64 | 1.51e-03 |
| GO:BP | GO:0051960 | regulation of nervous system development | 130 | 339 | 1.54e-03 |
| GO:BP | GO:0051146 | striated muscle cell differentiation | 95 | 234 | 1.54e-03 |
| GO:BP | GO:0040017 | positive regulation of locomotion | 155 | 416 | 1.60e-03 |
| GO:BP | GO:0000165 | MAPK cascade | 183 | 504 | 1.75e-03 |
| GO:BP | GO:0048705 | skeletal system morphogenesis | 65 | 148 | 1.75e-03 |
| GO:BP | GO:0007409 | axonogenesis | 129 | 337 | 1.78e-03 |
| GO:BP | GO:0030155 | regulation of cell adhesion | 184 | 508 | 1.93e-03 |
| GO:BP | GO:0010976 | positive regulation of neuron projection development | 58 | 129 | 2.00e-03 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | 349 | 1040 | 2.00e-03 |
| GO:BP | GO:0061564 | axon development | 140 | 372 | 2.14e-03 |
| GO:BP | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 167 | 456 | 2.22e-03 |
| GO:BP | GO:0048638 | regulation of developmental growth | 97 | 243 | 2.63e-03 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | 103 | 261 | 2.65e-03 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | 364 | 1093 | 2.69e-03 |
| GO:BP | GO:1990089 | response to nerve growth factor | 24 | 41 | 2.80e-03 |
| GO:BP | GO:1990090 | cellular response to nerve growth factor stimulus | 24 | 41 | 2.80e-03 |
| GO:BP | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 56 | 125 | 2.94e-03 |
| GO:BP | GO:0010810 | regulation of cell-substrate adhesion | 69 | 162 | 3.08e-03 |
| GO:BP | GO:0051216 | cartilage development | 63 | 145 | 3.15e-03 |
| GO:BP | GO:0023056 | positive regulation of signaling | 402 | 1221 | 3.17e-03 |
| GO:BP | GO:1990138 | neuron projection extension | 59 | 134 | 3.36e-03 |
| GO:BP | GO:0098609 | cell-cell adhesion | 200 | 564 | 3.42e-03 |
| GO:BP | GO:0010648 | negative regulation of cell communication | 345 | 1034 | 3.42e-03 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | 560 | 1751 | 3.42e-03 |
| GO:BP | GO:0003007 | heart morphogenesis | 88 | 218 | 3.42e-03 |
| GO:BP | GO:0016049 | cell growth | 142 | 382 | 3.42e-03 |
| GO:BP | GO:0060021 | roof of mouth development | 35 | 69 | 3.46e-03 |
| GO:BP | GO:0086002 | cardiac muscle cell action potential involved in contraction | 25 | 44 | 3.60e-03 |
| GO:BP | GO:0099537 | trans-synaptic signaling | 169 | 467 | 3.73e-03 |
| GO:BP | GO:0043410 | positive regulation of MAPK cascade | 111 | 288 | 3.96e-03 |
| GO:BP | GO:0010647 | positive regulation of cell communication | 400 | 1218 | 3.96e-03 |
| GO:BP | GO:0030048 | actin filament-based movement | 49 | 107 | 3.96e-03 |
| GO:BP | GO:0048592 | eye morphogenesis | 49 | 107 | 3.96e-03 |
| GO:BP | GO:0001667 | ameboidal-type cell migration | 129 | 344 | 4.50e-03 |
| GO:BP | GO:0051049 | regulation of transport | 363 | 1098 | 4.71e-03 |
| GO:BP | GO:0046834 | lipid phosphorylation | 9 | 10 | 4.71e-03 |
| GO:BP | GO:0007268 | chemical synaptic transmission | 167 | 463 | 4.71e-03 |
| GO:BP | GO:0098916 | anterograde trans-synaptic signaling | 167 | 463 | 4.71e-03 |
| GO:BP | GO:0050803 | regulation of synapse structure or activity | 73 | 176 | 4.71e-03 |
| GO:BP | GO:0050807 | regulation of synapse organization | 72 | 173 | 4.71e-03 |
| GO:BP | GO:0023057 | negative regulation of signaling | 344 | 1036 | 4.91e-03 |
| GO:BP | GO:0010632 | regulation of epithelial cell migration | 77 | 188 | 4.97e-03 |
| GO:BP | GO:0003013 | circulatory system process | 155 | 426 | 5.07e-03 |
| GO:BP | GO:0048511 | rhythmic process | 88 | 221 | 5.40e-03 |
| GO:BP | GO:2001222 | regulation of neuron migration | 22 | 38 | 6.20e-03 |
| GO:BP | GO:0050804 | modulation of chemical synaptic transmission | 121 | 322 | 6.27e-03 |
| GO:BP | GO:0022030 | telencephalon glial cell migration | 14 | 20 | 6.55e-03 |
| GO:BP | GO:0021801 | cerebral cortex radial glia-guided migration | 14 | 20 | 6.55e-03 |
| GO:BP | GO:0021885 | forebrain cell migration | 24 | 43 | 6.60e-03 |
| GO:BP | GO:0034762 | regulation of transmembrane transport | 113 | 298 | 6.69e-03 |
| GO:BP | GO:0070372 | regulation of ERK1 and ERK2 cascade | 72 | 175 | 6.69e-03 |
| GO:BP | GO:0007623 | circadian rhythm | 64 | 152 | 7.02e-03 |
| GO:BP | GO:0060560 | developmental growth involved in morphogenesis | 77 | 190 | 7.02e-03 |
| GO:BP | GO:0099177 | regulation of trans-synaptic signaling | 121 | 323 | 7.02e-03 |
| GO:BP | GO:0061448 | connective tissue development | 82 | 205 | 7.26e-03 |
| GO:BP | GO:0021543 | pallium development | 58 | 135 | 7.29e-03 |
| GO:BP | GO:2000146 | negative regulation of cell motility | 86 | 217 | 7.30e-03 |
| GO:BP | GO:0016310 | phosphorylation | 375 | 1145 | 7.58e-03 |
| GO:BP | GO:0022029 | telencephalon cell migration | 23 | 41 | 7.74e-03 |
| GO:BP | GO:0007186 | G protein-coupled receptor signaling pathway | 141 | 386 | 7.74e-03 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | 122 | 327 | 7.74e-03 |
| GO:BP | GO:0035265 | organ growth | 55 | 127 | 8.09e-03 |
| GO:BP | GO:0002062 | chondrocyte differentiation | 41 | 88 | 8.13e-03 |
| GO:BP | GO:0051241 | negative regulation of multicellular organismal process | 241 | 706 | 8.30e-03 |
| GO:BP | GO:0048729 | tissue morphogenesis | 162 | 453 | 8.56e-03 |
| GO:BP | GO:0046328 | regulation of JNK cascade | 47 | 105 | 9.13e-03 |
| GO:BP | GO:0032879 | regulation of localization | 462 | 1439 | 9.27e-03 |
| GO:BP | GO:0060429 | epithelium development | 267 | 792 | 9.27e-03 |
| GO:BP | GO:0006897 | endocytosis | 174 | 492 | 9.41e-03 |
| GO:BP | GO:0090132 | epithelium migration | 94 | 243 | 9.52e-03 |
| GO:BP | GO:0010631 | epithelial cell migration | 94 | 243 | 9.52e-03 |
| GO:BP | GO:0008154 | actin polymerization or depolymerization | 62 | 148 | 9.52e-03 |
| GO:BP | GO:0060998 | regulation of dendritic spine development | 26 | 49 | 9.52e-03 |
| GO:BP | GO:0021537 | telencephalon development | 78 | 195 | 9.52e-03 |
| GO:BP | GO:0030336 | negative regulation of cell migration | 83 | 210 | 9.64e-03 |
| GO:BP | GO:0051179 | localization | 1129 | 3731 | 9.72e-03 |
| GO:BP | GO:0051641 | cellular localization | 809 | 2623 | 1.02e-02 |
| GO:BP | GO:0001503 | ossification | 113 | 302 | 1.08e-02 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 748 | 2415 | 1.11e-02 |
| GO:BP | GO:0050877 | nervous system process | 207 | 600 | 1.15e-02 |
| GO:BP | GO:0048675 | axon extension | 43 | 95 | 1.16e-02 |
| GO:BP | GO:0010811 | positive regulation of cell-substrate adhesion | 43 | 95 | 1.16e-02 |
| GO:BP | GO:0060996 | dendritic spine development | 36 | 76 | 1.22e-02 |
| GO:BP | GO:0048568 | embryonic organ development | 113 | 303 | 1.22e-02 |
| GO:BP | GO:0035051 | cardiocyte differentiation | 56 | 132 | 1.22e-02 |
| GO:BP | GO:0070252 | actin-mediated cell contraction | 40 | 87 | 1.24e-02 |
| GO:BP | GO:0051057 | positive regulation of small GTPase mediated signal transduction | 28 | 55 | 1.28e-02 |
| GO:BP | GO:0110053 | regulation of actin filament organization | 83 | 212 | 1.31e-02 |
| GO:BP | GO:0009952 | anterior/posterior pattern specification | 52 | 121 | 1.34e-02 |
| GO:BP | GO:0045785 | positive regulation of cell adhesion | 112 | 301 | 1.40e-02 |
| GO:BP | GO:0071407 | cellular response to organic cyclic compound | 137 | 379 | 1.40e-02 |
| GO:BP | GO:0042692 | muscle cell differentiation | 119 | 323 | 1.44e-02 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | 160 | 452 | 1.44e-02 |
| GO:BP | GO:0040013 | negative regulation of locomotion | 93 | 243 | 1.44e-02 |
| GO:BP | GO:0030516 | regulation of axon extension | 35 | 74 | 1.45e-02 |
| GO:BP | GO:0007611 | learning or memory | 75 | 189 | 1.51e-02 |
| GO:BP | GO:0021953 | central nervous system neuron differentiation | 44 | 99 | 1.53e-02 |
| GO:BP | GO:0007398 | ectoderm development | 10 | 13 | 1.57e-02 |
| GO:BP | GO:0001508 | action potential | 45 | 102 | 1.58e-02 |
| GO:BP | GO:0099643 | signal release from synapse | 45 | 102 | 1.58e-02 |
| GO:BP | GO:0007269 | neurotransmitter secretion | 45 | 102 | 1.58e-02 |
| GO:BP | GO:0051336 | regulation of hydrolase activity | 153 | 431 | 1.60e-02 |
| GO:BP | GO:0043583 | ear development | 62 | 151 | 1.61e-02 |
| GO:BP | GO:0090130 | tissue migration | 94 | 247 | 1.62e-02 |
| GO:BP | GO:0055007 | cardiac muscle cell differentiation | 46 | 105 | 1.63e-02 |
| GO:BP | GO:0050770 | regulation of axonogenesis | 53 | 125 | 1.64e-02 |
| GO:BP | GO:0043087 | regulation of GTPase activity | 67 | 166 | 1.68e-02 |
| GO:BP | GO:0007411 | axon guidance | 69 | 172 | 1.68e-02 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | 190 | 550 | 1.68e-02 |
| GO:BP | GO:0016192 | vesicle-mediated transport | 373 | 1152 | 1.68e-02 |
| GO:BP | GO:0097485 | neuron projection guidance | 69 | 172 | 1.68e-02 |
| GO:BP | GO:0051017 | actin filament bundle assembly | 55 | 131 | 1.69e-02 |
| GO:BP | GO:0045995 | regulation of embryonic development | 34 | 72 | 1.69e-02 |
| GO:BP | GO:0031032 | actomyosin structure organization | 73 | 184 | 1.69e-02 |
| GO:BP | GO:0055017 | cardiac muscle tissue growth | 31 | 64 | 1.71e-02 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | 433 | 1354 | 1.75e-02 |
| GO:BP | GO:0007610 | behavior | 149 | 420 | 1.85e-02 |
| GO:BP | GO:0018105 | peptidyl-serine phosphorylation | 65 | 161 | 1.93e-02 |
| GO:BP | GO:0061383 | trabecula morphogenesis | 22 | 41 | 1.95e-02 |
| GO:BP | GO:0090596 | sensory organ morphogenesis | 69 | 173 | 1.95e-02 |
| GO:BP | GO:0048617 | embryonic foregut morphogenesis | 6 | 6 | 1.95e-02 |
| GO:BP | GO:0021814 | cell motility involved in cerebral cortex radial glia guided migration | 6 | 6 | 1.95e-02 |
| GO:BP | GO:0065009 | regulation of molecular function | 416 | 1299 | 1.97e-02 |
| GO:BP | GO:0061572 | actin filament bundle organization | 55 | 132 | 2.01e-02 |
| GO:BP | GO:0010033 | response to organic substance | 545 | 1736 | 2.06e-02 |
| GO:BP | GO:0099175 | regulation of postsynapse organization | 37 | 81 | 2.06e-02 |
| GO:BP | GO:0035725 | sodium ion transmembrane transport | 42 | 95 | 2.08e-02 |
| GO:BP | GO:0150115 | cell-substrate junction organization | 42 | 95 | 2.08e-02 |
| GO:BP | GO:0071310 | cellular response to organic substance | 415 | 1297 | 2.11e-02 |
| GO:BP | GO:0086005 | ventricular cardiac muscle cell action potential | 17 | 29 | 2.11e-02 |
| GO:BP | GO:0044089 | positive regulation of cellular component biogenesis | 139 | 390 | 2.15e-02 |
| GO:BP | GO:0050890 | cognition | 82 | 213 | 2.20e-02 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | 803 | 2622 | 2.22e-02 |
| GO:BP | GO:0048593 | camera-type eye morphogenesis | 39 | 87 | 2.27e-02 |
| GO:BP | GO:0007254 | JNK cascade | 53 | 127 | 2.31e-02 |
| GO:BP | GO:0018210 | peptidyl-threonine modification | 35 | 76 | 2.31e-02 |
| GO:BP | GO:0010720 | positive regulation of cell development | 113 | 309 | 2.32e-02 |
| GO:BP | GO:0034220 | monoatomic ion transmembrane transport | 200 | 587 | 2.41e-02 |
| GO:BP | GO:0007612 | learning | 47 | 110 | 2.45e-02 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | 317 | 972 | 2.45e-02 |
| GO:BP | GO:0021987 | cerebral cortex development | 41 | 93 | 2.47e-02 |
| GO:BP | GO:0120033 | negative regulation of plasma membrane bounded cell projection assembly | 16 | 27 | 2.50e-02 |
| GO:BP | GO:0040008 | regulation of growth | 161 | 462 | 2.57e-02 |
| GO:BP | GO:0032271 | regulation of protein polymerization | 64 | 160 | 2.58e-02 |
| GO:BP | GO:0060419 | heart growth | 33 | 71 | 2.59e-02 |
| GO:BP | GO:0018209 | peptidyl-serine modification | 67 | 169 | 2.59e-02 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | 395 | 1234 | 2.62e-02 |
| GO:BP | GO:0086001 | cardiac muscle cell action potential | 30 | 63 | 2.66e-02 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | 394 | 1231 | 2.66e-02 |
| GO:BP | GO:0006811 | monoatomic ion transport | 240 | 719 | 2.66e-02 |
| GO:BP | GO:0032231 | regulation of actin filament bundle assembly | 38 | 85 | 2.67e-02 |
| GO:BP | GO:0001954 | positive regulation of cell-matrix adhesion | 22 | 42 | 2.67e-02 |
| GO:BP | GO:0007517 | muscle organ development | 99 | 267 | 2.72e-02 |
| GO:BP | GO:0030001 | metal ion transport | 180 | 524 | 2.72e-02 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | 39 | 88 | 2.78e-02 |
| GO:BP | GO:0006814 | sodium ion transport | 56 | 137 | 2.81e-02 |
| GO:BP | GO:0098657 | import into cell | 210 | 622 | 2.86e-02 |
| GO:BP | GO:0035025 | positive regulation of Rho protein signal transduction | 15 | 25 | 2.90e-02 |
| GO:BP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 47 | 111 | 2.91e-02 |
| GO:BP | GO:0014070 | response to organic cyclic compound | 205 | 606 | 2.91e-02 |
| GO:BP | GO:0051234 | establishment of localization | 979 | 3240 | 2.92e-02 |
| GO:BP | GO:1902533 | positive regulation of intracellular signal transduction | 238 | 714 | 2.92e-02 |
| GO:BP | GO:0006898 | receptor-mediated endocytosis | 71 | 182 | 2.93e-02 |
| GO:BP | GO:0018107 | peptidyl-threonine phosphorylation | 32 | 69 | 3.03e-02 |
| GO:BP | GO:0003281 | ventricular septum development | 32 | 69 | 3.03e-02 |
| GO:BP | GO:0050709 | negative regulation of protein secretion | 23 | 45 | 3.04e-02 |
| GO:BP | GO:0019722 | calcium-mediated signaling | 51 | 123 | 3.11e-02 |
| GO:BP | GO:0140352 | export from cell | 201 | 594 | 3.12e-02 |
| GO:BP | GO:0042592 | homeostatic process | 365 | 1137 | 3.12e-02 |
| GO:BP | GO:0048546 | digestive tract morphogenesis | 17 | 30 | 3.13e-02 |
| GO:BP | GO:0060323 | head morphogenesis | 17 | 30 | 3.13e-02 |
| GO:BP | GO:0060065 | uterus development | 10 | 14 | 3.13e-02 |
| GO:BP | GO:0002363 | alpha-beta T cell lineage commitment | 10 | 14 | 3.13e-02 |
| GO:BP | GO:0060412 | ventricular septum morphogenesis | 21 | 40 | 3.14e-02 |
| GO:BP | GO:0055013 | cardiac muscle cell development | 33 | 72 | 3.17e-02 |
| GO:BP | GO:0086091 | regulation of heart rate by cardiac conduction | 19 | 35 | 3.18e-02 |
| GO:BP | GO:0003012 | muscle system process | 117 | 325 | 3.21e-02 |
| GO:BP | GO:0038203 | TORC2 signaling | 8 | 10 | 3.21e-02 |
| GO:BP | GO:0045176 | apical protein localization | 9 | 12 | 3.25e-02 |
| GO:BP | GO:0032486 | Rap protein signal transduction | 9 | 12 | 3.25e-02 |
| GO:BP | GO:0046339 | diacylglycerol metabolic process | 14 | 23 | 3.30e-02 |
| GO:BP | GO:0010977 | negative regulation of neuron projection development | 46 | 109 | 3.30e-02 |
| GO:BP | GO:0050772 | positive regulation of axonogenesis | 30 | 64 | 3.30e-02 |
| GO:BP | GO:1901888 | regulation of cell junction assembly | 62 | 156 | 3.30e-02 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | 648 | 2100 | 3.31e-02 |
| GO:BP | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 24 | 48 | 3.33e-02 |
| GO:BP | GO:0030198 | extracellular matrix organization | 84 | 223 | 3.45e-02 |
| GO:BP | GO:0030832 | regulation of actin filament length | 49 | 118 | 3.49e-02 |
| GO:BP | GO:0060411 | cardiac septum morphogenesis | 31 | 67 | 3.52e-02 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | 110 | 304 | 3.52e-02 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | 144 | 412 | 3.57e-02 |
| GO:BP | GO:0030041 | actin filament polymerization | 51 | 124 | 3.57e-02 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | 92 | 248 | 3.57e-02 |
| GO:BP | GO:0010634 | positive regulation of epithelial cell migration | 52 | 127 | 3.60e-02 |
| GO:BP | GO:0044319 | wound healing, spreading of cells | 16 | 28 | 3.62e-02 |
| GO:BP | GO:0090505 | epiboly involved in wound healing | 16 | 28 | 3.62e-02 |
| GO:BP | GO:0048839 | inner ear development | 54 | 133 | 3.65e-02 |
| GO:BP | GO:0051896 | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 70 | 181 | 3.72e-02 |
| GO:BP | GO:0006810 | transport | 903 | 2984 | 3.72e-02 |
| GO:BP | GO:0032924 | activin receptor signaling pathway | 18 | 33 | 3.72e-02 |
| GO:BP | GO:0050769 | positive regulation of neurogenesis | 71 | 184 | 3.72e-02 |
| GO:BP | GO:0007160 | cell-matrix adhesion | 66 | 169 | 3.75e-02 |
| GO:BP | GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 62 | 157 | 3.75e-02 |
| GO:BP | GO:0043062 | extracellular structure organization | 84 | 224 | 3.81e-02 |
| GO:BP | GO:0045229 | external encapsulating structure organization | 84 | 224 | 3.81e-02 |
| GO:BP | GO:0110020 | regulation of actomyosin structure organization | 38 | 87 | 3.82e-02 |
| GO:BP | GO:0010586 | miRNA metabolic process | 38 | 87 | 3.82e-02 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | 296 | 911 | 3.83e-02 |
| GO:BP | GO:0051962 | positive regulation of nervous system development | 80 | 212 | 3.93e-02 |
| GO:BP | GO:0003407 | neural retina development | 23 | 46 | 3.93e-02 |
| GO:BP | GO:0031324 | negative regulation of cellular metabolic process | 598 | 1934 | 4.04e-02 |
| GO:BP | GO:0070371 | ERK1 and ERK2 cascade | 74 | 194 | 4.12e-02 |
| GO:BP | GO:1903522 | regulation of blood circulation | 74 | 194 | 4.12e-02 |
| GO:BP | GO:0003170 | heart valve development | 30 | 65 | 4.12e-02 |
| GO:BP | GO:0010171 | body morphogenesis | 21 | 41 | 4.20e-02 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | 95 | 259 | 4.21e-02 |
| GO:BP | GO:0002761 | regulation of myeloid leukocyte differentiation | 35 | 79 | 4.21e-02 |
| GO:BP | GO:0045444 | fat cell differentiation | 69 | 179 | 4.22e-02 |
| GO:BP | GO:0097484 | dendrite extension | 15 | 26 | 4.22e-02 |
| GO:BP | GO:0021799 | cerebral cortex radially oriented cell migration | 15 | 26 | 4.22e-02 |
| GO:BP | GO:0098655 | monoatomic cation transmembrane transport | 169 | 495 | 4.28e-02 |
| GO:BP | GO:0008015 | blood circulation | 126 | 357 | 4.29e-02 |
| GO:BP | GO:0002360 | T cell lineage commitment | 12 | 19 | 4.29e-02 |
| GO:BP | GO:0032233 | positive regulation of actin filament bundle assembly | 24 | 49 | 4.29e-02 |
| GO:BP | GO:0098660 | inorganic ion transmembrane transport | 177 | 521 | 4.29e-02 |
| GO:BP | GO:0030833 | regulation of actin filament polymerization | 43 | 102 | 4.30e-02 |
| GO:BP | GO:0034765 | regulation of monoatomic ion transmembrane transport | 79 | 210 | 4.43e-02 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | 284 | 874 | 4.50e-02 |
| GO:BP | GO:0051345 | positive regulation of hydrolase activity | 97 | 266 | 4.53e-02 |
| GO:BP | GO:0072659 | protein localization to plasma membrane | 88 | 238 | 4.53e-02 |
| GO:BP | GO:0033036 | macromolecule localization | 706 | 2309 | 4.63e-02 |
| GO:BP | GO:0008064 | regulation of actin polymerization or depolymerization | 48 | 117 | 4.66e-02 |
| GO:BP | GO:0002042 | cell migration involved in sprouting angiogenesis | 22 | 44 | 4.66e-02 |
| GO:BP | GO:0042391 | regulation of membrane potential | 102 | 282 | 4.67e-02 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | 70 | 183 | 4.73e-02 |
| GO:BP | GO:0018193 | peptidyl-amino acid modification | 187 | 555 | 4.74e-02 |
| GO:BP | GO:0003186 | tricuspid valve morphogenesis | 5 | 5 | 4.77e-02 |
| GO:BP | GO:0006836 | neurotransmitter transport | 54 | 135 | 4.77e-02 |
| GO:BP | GO:0061038 | uterus morphogenesis | 5 | 5 | 4.77e-02 |
| GO:BP | GO:0021815 | modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration | 5 | 5 | 4.77e-02 |
| GO:BP | GO:0097061 | dendritic spine organization | 29 | 63 | 4.77e-02 |
| GO:BP | GO:0035696 | monocyte extravasation | 5 | 5 | 4.77e-02 |
| GO:BP | GO:0048878 | chemical homeostasis | 222 | 670 | 4.77e-02 |
| GO:BP | GO:0045637 | regulation of myeloid cell differentiation | 54 | 135 | 4.77e-02 |
| GO:BP | GO:1905274 | regulation of modification of postsynaptic actin cytoskeleton | 5 | 5 | 4.77e-02 |
| GO:BP | GO:1902905 | positive regulation of supramolecular fiber organization | 55 | 138 | 4.78e-02 |
| GO:BP | GO:0060491 | regulation of cell projection assembly | 62 | 159 | 4.78e-02 |
| GO:BP | GO:0099173 | postsynapse organization | 58 | 147 | 4.79e-02 |
| GO:BP | GO:0035313 | wound healing, spreading of epidermal cells | 11 | 17 | 4.79e-02 |
| GO:BP | GO:0051492 | regulation of stress fiber assembly | 34 | 77 | 4.79e-02 |
| GO:BP | GO:0048048 | embryonic eye morphogenesis | 14 | 24 | 4.84e-02 |
| GO:BP | GO:0044093 | positive regulation of molecular function | 256 | 783 | 4.91e-02 |
| GO:BP | GO:0003179 | heart valve morphogenesis | 26 | 55 | 4.95e-02 |
| GO:BP | GO:0007389 | pattern specification process | 103 | 286 | 4.96e-02 |
EARnomtable_20k %>%
filter(source=="KEGG", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in EAR neargenes_20k") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:04510 | Focal adhesion | 79 | 169 | 5.32e-05 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | 73 | 162 | 4.35e-04 |
| KEGG | KEGG:04520 | Adherens junction | 42 | 83 | 1.27e-03 |
| KEGG | KEGG:04310 | Wnt signaling pathway | 58 | 133 | 6.21e-03 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 68 | 162 | 6.21e-03 |
| KEGG | KEGG:04360 | Axon guidance | 65 | 155 | 7.57e-03 |
| KEGG | KEGG:04713 | Circadian entrainment | 33 | 68 | 1.29e-02 |
| KEGG | KEGG:03013 | Nucleocytoplasmic transport | 43 | 96 | 1.40e-02 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | 34 | 73 | 2.14e-02 |
| KEGG | KEGG:04512 | ECM-receptor interaction | 31 | 66 | 2.78e-02 |
| KEGG | KEGG:04530 | Tight junction | 53 | 129 | 2.94e-02 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 35 | 78 | 3.11e-02 |
| KEGG | KEGG:04720 | Long-term potentiation | 25 | 51 | 3.12e-02 |
| KEGG | KEGG:00561 | Glycerolipid metabolism | 22 | 44 | 4.07e-02 |
| KEGG | KEGG:04730 | Long-term depression | 20 | 39 | 4.12e-02 |
| KEGG | KEGG:04974 | Protein digestion and absorption | 26 | 56 | 4.54e-02 |
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | 30 | 67 | 4.54e-02 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | 46 | 113 | 4.54e-02 |
| KEGG | KEGG:04742 | Taste transduction | 12 | 20 | 4.54e-02 |
| KEGG | KEGG:05200 | Pathways in cancer | 135 | 391 | 4.54e-02 |
| KEGG | KEGG:04072 | Phospholipase D signaling pathway | 44 | 107 | 4.54e-02 |
EAR peaks overlapping enhancers
# EAR_resgenes_20k_enh <- gost(query = unique(EAR_enh_peaks_20k$NCBI_gene),
# organism = "hsapiens",
# significant = FALSE,
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = background_df$ENTREZID,
# sources=c("GO:BP","KEGG"))
# saveRDS(EAR_resgenes_20k_enh,"data/GO_KEGG_analysis/EAR_resgenes_20k_enh.RDS")
# EARnom <- gostplot(EAR_resgenes_20k_enh, capped = FALSE, interactive = TRUE)
# EARnom
EARnomtable_20k_enh <- EAR_resgenes_20k_enh$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
EARnomtable_20k_enh %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in EAR enhancer neargenes_20k" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0050789 | regulation of biological process | 579 | 7516 | 8.40e-13 |
| GO:BP | GO:0050794 | regulation of cellular process | 556 | 7153 | 1.41e-12 |
| GO:BP | GO:0065007 | biological regulation | 587 | 7734 | 5.33e-12 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 344 | 3954 | 1.64e-10 |
| GO:BP | GO:0048518 | positive regulation of biological process | 366 | 4301 | 2.84e-10 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | 146 | 1354 | 1.67e-08 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | 135 | 1231 | 3.06e-08 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | 135 | 1234 | 3.18e-08 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 304 | 3550 | 5.73e-08 |
| GO:BP | GO:0048519 | negative regulation of biological process | 318 | 3764 | 7.00e-08 |
| GO:BP | GO:0032502 | developmental process | 339 | 4179 | 1.68e-06 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | 171 | 1791 | 1.77e-06 |
| GO:BP | GO:0050793 | regulation of developmental process | 164 | 1697 | 1.77e-06 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 150 | 1514 | 1.77e-06 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 174 | 1844 | 2.80e-06 |
| GO:BP | GO:0048856 | anatomical structure development | 316 | 3867 | 3.01e-06 |
| GO:BP | GO:0031328 | positive regulation of cellular biosynthetic process | 173 | 1841 | 3.77e-06 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | 174 | 1856 | 3.79e-06 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | 230 | 2663 | 1.11e-05 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 172 | 1862 | 1.25e-05 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | 166 | 1787 | 1.51e-05 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | 226 | 2622 | 1.60e-05 |
| GO:BP | GO:0051173 | positive regulation of nitrogen compound metabolic process | 194 | 2186 | 2.42e-05 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | 171 | 1879 | 3.04e-05 |
| GO:BP | GO:0048869 | cellular developmental process | 237 | 2804 | 3.04e-05 |
| GO:BP | GO:0030154 | cell differentiation | 237 | 2803 | 3.04e-05 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | 209 | 2410 | 3.31e-05 |
| GO:BP | GO:0032501 | multicellular organismal process | 351 | 4504 | 3.63e-05 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 209 | 2415 | 3.63e-05 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | 209 | 2422 | 4.41e-05 |
| GO:BP | GO:0051171 | regulation of nitrogen compound metabolic process | 311 | 3918 | 5.45e-05 |
| GO:BP | GO:0031325 | positive regulation of cellular metabolic process | 202 | 2333 | 5.65e-05 |
| GO:BP | GO:0006351 | DNA-templated transcription | 214 | 2510 | 6.90e-05 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | 281 | 3486 | 7.41e-05 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | 92 | 874 | 8.52e-05 |
| GO:BP | GO:0007275 | multicellular organism development | 259 | 3170 | 8.66e-05 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | 240 | 2895 | 8.81e-05 |
| GO:BP | GO:0010468 | regulation of gene expression | 273 | 3379 | 8.99e-05 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | 315 | 4015 | 1.10e-04 |
| GO:BP | GO:0032774 | RNA biosynthetic process | 214 | 2533 | 1.10e-04 |
| GO:BP | GO:0040007 | growth | 77 | 697 | 1.10e-04 |
| GO:BP | GO:0048731 | system development | 227 | 2719 | 1.10e-04 |
| GO:BP | GO:0031326 | regulation of cellular biosynthetic process | 285 | 3569 | 1.11e-04 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | 286 | 3595 | 1.42e-04 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 170 | 1924 | 1.42e-04 |
| GO:BP | GO:0031324 | negative regulation of cellular metabolic process | 170 | 1934 | 1.90e-04 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | 148 | 1635 | 2.08e-04 |
| GO:BP | GO:0031327 | negative regulation of cellular biosynthetic process | 147 | 1624 | 2.23e-04 |
| GO:BP | GO:0050896 | response to stimulus | 401 | 5379 | 2.36e-04 |
| GO:BP | GO:0072359 | circulatory system development | 89 | 864 | 2.36e-04 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | 144 | 1588 | 2.49e-04 |
| GO:BP | GO:0141124 | intracellular signaling cassette | 123 | 1314 | 3.34e-04 |
| GO:BP | GO:0009987 | cellular process | 713 | 10686 | 3.95e-04 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | 325 | 4231 | 3.95e-04 |
| GO:BP | GO:0019222 | regulation of metabolic process | 349 | 4603 | 4.36e-04 |
| GO:BP | GO:0008150 | biological_process | 741 | 11244 | 5.30e-04 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | 179 | 2100 | 5.42e-04 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 110 | 1157 | 5.42e-04 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | 103 | 1067 | 5.71e-04 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | 232 | 2867 | 6.18e-04 |
| GO:BP | GO:0010586 | miRNA metabolic process | 18 | 87 | 6.29e-04 |
| GO:BP | GO:0071310 | cellular response to organic substance | 120 | 1297 | 6.70e-04 |
| GO:BP | GO:0031323 | regulation of cellular metabolic process | 323 | 4233 | 7.16e-04 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | 66 | 609 | 8.43e-04 |
| GO:BP | GO:0001568 | blood vessel development | 59 | 525 | 8.47e-04 |
| GO:BP | GO:0051094 | positive regulation of developmental process | 90 | 913 | 9.42e-04 |
| GO:BP | GO:0001944 | vasculature development | 61 | 552 | 9.79e-04 |
| GO:BP | GO:0010033 | response to organic substance | 151 | 1736 | 1.06e-03 |
| GO:BP | GO:0051716 | cellular response to stimulus | 348 | 4640 | 1.11e-03 |
| GO:BP | GO:0043408 | regulation of MAPK cascade | 50 | 427 | 1.28e-03 |
| GO:BP | GO:0051172 | negative regulation of nitrogen compound metabolic process | 143 | 1633 | 1.30e-03 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | 93 | 965 | 1.50e-03 |
| GO:BP | GO:0048589 | developmental growth | 56 | 501 | 1.50e-03 |
| GO:BP | GO:0010648 | negative regulation of cell communication | 98 | 1034 | 1.69e-03 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 98 | 1035 | 1.73e-03 |
| GO:BP | GO:0023052 | signaling | 299 | 3918 | 1.79e-03 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | 93 | 973 | 1.92e-03 |
| GO:BP | GO:0007154 | cell communication | 303 | 3983 | 1.92e-03 |
| GO:BP | GO:0018130 | heterocycle biosynthetic process | 232 | 2927 | 2.12e-03 |
| GO:BP | GO:0019438 | aromatic compound biosynthetic process | 232 | 2928 | 2.15e-03 |
| GO:BP | GO:0060419 | heart growth | 15 | 71 | 2.15e-03 |
| GO:BP | GO:0040008 | regulation of growth | 52 | 462 | 2.22e-03 |
| GO:BP | GO:0061061 | muscle structure development | 58 | 536 | 2.42e-03 |
| GO:BP | GO:0055017 | cardiac muscle tissue growth | 14 | 64 | 2.53e-03 |
| GO:BP | GO:0023057 | negative regulation of signaling | 97 | 1036 | 2.63e-03 |
| GO:BP | GO:0048468 | cell development | 159 | 1886 | 2.63e-03 |
| GO:BP | GO:0016477 | cell migration | 95 | 1011 | 2.67e-03 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 109 | 1197 | 2.67e-03 |
| GO:BP | GO:0016043 | cellular component organization | 355 | 4802 | 2.67e-03 |
| GO:BP | GO:0000165 | MAPK cascade | 55 | 504 | 2.84e-03 |
| GO:BP | GO:0048513 | animal organ development | 167 | 2004 | 2.85e-03 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | 163 | 1951 | 3.09e-03 |
| GO:BP | GO:0035556 | intracellular signal transduction | 163 | 1951 | 3.09e-03 |
| GO:BP | GO:1901362 | organic cyclic compound biosynthetic process | 237 | 3026 | 3.23e-03 |
| GO:BP | GO:0010646 | regulation of cell communication | 197 | 2444 | 3.50e-03 |
| GO:BP | GO:0048514 | blood vessel morphogenesis | 50 | 450 | 3.76e-03 |
| GO:BP | GO:0035295 | tube development | 77 | 787 | 3.79e-03 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | 11 | 44 | 4.08e-03 |
| GO:BP | GO:0016070 | RNA metabolic process | 258 | 3352 | 4.08e-03 |
| GO:BP | GO:0023051 | regulation of signaling | 196 | 2438 | 4.08e-03 |
| GO:BP | GO:0001525 | angiogenesis | 44 | 381 | 4.08e-03 |
| GO:BP | GO:0016049 | cell growth | 44 | 382 | 4.22e-03 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 365 | 4988 | 4.22e-03 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | 13 | 60 | 4.24e-03 |
| GO:BP | GO:0007165 | signal transduction | 275 | 3611 | 4.24e-03 |
| GO:BP | GO:0060644 | mammary gland epithelial cell differentiation | 6 | 13 | 4.24e-03 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | 89 | 951 | 4.62e-03 |
| GO:BP | GO:0061614 | miRNA transcription | 13 | 61 | 4.94e-03 |
| GO:BP | GO:0042221 | response to chemical | 186 | 2304 | 4.94e-03 |
| GO:BP | GO:0046328 | regulation of JNK cascade | 18 | 105 | 4.99e-03 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | 147 | 1751 | 5.34e-03 |
| GO:BP | GO:0048870 | cell motility | 101 | 1120 | 6.04e-03 |
| GO:BP | GO:0010842 | retina layer formation | 6 | 14 | 6.58e-03 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | 14 | 72 | 7.29e-03 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | 80 | 850 | 8.39e-03 |
| GO:BP | GO:0033500 | carbohydrate homeostasis | 24 | 170 | 8.62e-03 |
| GO:BP | GO:0001678 | intracellular glucose homeostasis | 18 | 110 | 8.69e-03 |
| GO:BP | GO:0051641 | cellular localization | 206 | 2623 | 8.73e-03 |
| GO:BP | GO:2000145 | regulation of cell motility | 68 | 700 | 1.04e-02 |
| GO:BP | GO:0035239 | tube morphogenesis | 63 | 638 | 1.14e-02 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | 11 | 50 | 1.15e-02 |
| GO:BP | GO:0048699 | generation of neurons | 96 | 1076 | 1.22e-02 |
| GO:BP | GO:0097240 | chromosome attachment to the nuclear envelope | 3 | 3 | 1.27e-02 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | 78 | 837 | 1.29e-02 |
| GO:BP | GO:0040012 | regulation of locomotion | 69 | 720 | 1.32e-02 |
| GO:BP | GO:0006325 | chromatin organization | 60 | 604 | 1.32e-02 |
| GO:BP | GO:0001558 | regulation of cell growth | 37 | 323 | 1.38e-02 |
| GO:BP | GO:0060041 | retina development in camera-type eye | 17 | 105 | 1.38e-02 |
| GO:BP | GO:0030182 | neuron differentiation | 91 | 1014 | 1.38e-02 |
| GO:BP | GO:0061117 | negative regulation of heart growth | 6 | 16 | 1.38e-02 |
| GO:BP | GO:0055022 | negative regulation of cardiac muscle tissue growth | 6 | 16 | 1.38e-02 |
| GO:BP | GO:0042592 | homeostatic process | 100 | 1137 | 1.40e-02 |
| GO:BP | GO:0051179 | localization | 278 | 3731 | 1.50e-02 |
| GO:BP | GO:0035265 | organ growth | 19 | 127 | 1.67e-02 |
| GO:BP | GO:0042593 | glucose homeostasis | 23 | 169 | 1.73e-02 |
| GO:BP | GO:0014706 | striated muscle tissue development | 27 | 213 | 1.79e-02 |
| GO:BP | GO:0030029 | actin filament-based process | 62 | 640 | 1.87e-02 |
| GO:BP | GO:0032879 | regulation of localization | 121 | 1439 | 1.87e-02 |
| GO:BP | GO:0030334 | regulation of cell migration | 64 | 668 | 2.00e-02 |
| GO:BP | GO:0060044 | negative regulation of cardiac muscle cell proliferation | 4 | 7 | 2.09e-02 |
| GO:BP | GO:0060159 | regulation of dopamine receptor signaling pathway | 4 | 7 | 2.09e-02 |
| GO:BP | GO:0071824 | protein-DNA complex organization | 65 | 683 | 2.12e-02 |
| GO:BP | GO:0022008 | neurogenesis | 107 | 1251 | 2.21e-02 |
| GO:BP | GO:0045595 | regulation of cell differentiation | 94 | 1073 | 2.26e-02 |
| GO:BP | GO:0031346 | positive regulation of cell projection organization | 33 | 286 | 2.27e-02 |
| GO:BP | GO:0045926 | negative regulation of growth | 24 | 184 | 2.27e-02 |
| GO:BP | GO:0040011 | locomotion | 74 | 805 | 2.34e-02 |
| GO:BP | GO:0050772 | positive regulation of axonogenesis | 12 | 64 | 2.37e-02 |
| GO:BP | GO:0009725 | response to hormone | 59 | 610 | 2.46e-02 |
| GO:BP | GO:0033993 | response to lipid | 56 | 573 | 2.61e-02 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | 95 | 1093 | 2.61e-02 |
| GO:BP | GO:0044271 | cellular nitrogen compound biosynthetic process | 260 | 3495 | 2.61e-02 |
| GO:BP | GO:0097306 | cellular response to alcohol | 13 | 74 | 2.63e-02 |
| GO:BP | GO:0048667 | cell morphogenesis involved in neuron differentiation | 45 | 435 | 2.65e-02 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 66 | 704 | 2.65e-02 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | 86 | 972 | 2.68e-02 |
| GO:BP | GO:0014741 | negative regulation of muscle hypertrophy | 7 | 25 | 2.69e-02 |
| GO:BP | GO:0033036 | macromolecule localization | 180 | 2309 | 2.85e-02 |
| GO:BP | GO:0060537 | muscle tissue development | 37 | 339 | 2.87e-02 |
| GO:BP | GO:0009966 | regulation of signal transduction | 170 | 2166 | 3.01e-02 |
| GO:BP | GO:0048878 | chemical homeostasis | 63 | 670 | 3.12e-02 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | 52 | 528 | 3.15e-02 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | 25 | 201 | 3.20e-02 |
| GO:BP | GO:0031344 | regulation of cell projection organization | 51 | 516 | 3.22e-02 |
| GO:BP | GO:0006810 | transport | 225 | 2984 | 3.23e-02 |
| GO:BP | GO:0051726 | regulation of cell cycle | 79 | 885 | 3.24e-02 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 207 | 2717 | 3.28e-02 |
| GO:BP | GO:0010975 | regulation of neuron projection development | 38 | 355 | 3.35e-02 |
| GO:BP | GO:0120035 | regulation of plasma membrane bounded cell projection organization | 50 | 505 | 3.37e-02 |
| GO:BP | GO:1903294 | regulation of glutamate secretion, neurotransmission | 3 | 4 | 3.51e-02 |
| GO:BP | GO:0007254 | JNK cascade | 18 | 127 | 3.56e-02 |
| GO:BP | GO:0007015 | actin filament organization | 38 | 357 | 3.64e-02 |
| GO:BP | GO:0072659 | protein localization to plasma membrane | 28 | 238 | 3.66e-02 |
| GO:BP | GO:0070848 | response to growth factor | 53 | 547 | 3.81e-02 |
| GO:BP | GO:0007399 | nervous system development | 142 | 1775 | 3.82e-02 |
| GO:BP | GO:0032880 | regulation of protein localization | 64 | 691 | 3.82e-02 |
| GO:BP | GO:0043933 | protein-containing complex organization | 148 | 1863 | 3.91e-02 |
| GO:BP | GO:0048661 | positive regulation of smooth muscle cell proliferation | 11 | 60 | 4.01e-02 |
| GO:BP | GO:1990778 | protein localization to cell periphery | 32 | 287 | 4.01e-02 |
| GO:BP | GO:2000045 | regulation of G1/S transition of mitotic cell cycle | 19 | 140 | 4.17e-02 |
| GO:BP | GO:0006338 | chromatin remodeling | 48 | 486 | 4.17e-02 |
| GO:BP | GO:0043410 | positive regulation of MAPK cascade | 32 | 288 | 4.17e-02 |
| GO:BP | GO:0007266 | Rho protein signal transduction | 16 | 109 | 4.28e-02 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | 276 | 3777 | 4.28e-02 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | 56 | 591 | 4.40e-02 |
| GO:BP | GO:0030307 | positive regulation of cell growth | 17 | 120 | 4.50e-02 |
| GO:BP | GO:0033002 | muscle cell proliferation | 20 | 152 | 4.50e-02 |
| GO:BP | GO:0140747 | regulation of ncRNA transcription | 13 | 80 | 4.56e-02 |
| GO:BP | GO:0048638 | regulation of developmental growth | 28 | 243 | 4.61e-02 |
| GO:BP | GO:0070372 | regulation of ERK1 and ERK2 cascade | 22 | 175 | 4.78e-02 |
| GO:BP | GO:0007264 | small GTPase-mediated signal transduction | 40 | 390 | 4.91e-02 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | 89 | 1040 | 4.91e-02 |
| GO:BP | GO:0048511 | rhythmic process | 26 | 221 | 4.91e-02 |
| GO:BP | GO:0048103 | somatic stem cell division | 4 | 9 | 4.91e-02 |
| GO:BP | GO:0034380 | high-density lipoprotein particle assembly | 4 | 9 | 4.91e-02 |
| GO:BP | GO:0051093 | negative regulation of developmental process | 58 | 622 | 4.98e-02 |
EARnomtable_20k_enh %>%
filter(source=="KEGG", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in EAR enhancer neargenes_20k") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:05203 | Viral carcinogenesis | 22 | 142 | 2.18e-02 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 23 | 162 | 2.93e-02 |
ESR 20,000 bp NG
# ESR_resgenes_20k <- gost(query = ESR_peak_list_20k$ENTREZID,
# organism = "hsapiens",
# significant = FALSE,
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = background_df$ENTREZID,
# sources=c("GO:BP","KEGG"))
# saveRDS(ESR_resgenes_20k,"data/GO_KEGG_analysis/ESR_resgenes_20k.RDS")
# ESRnom <- gostplot(ESR_resgenes_20k, capped = FALSE, interactive = TRUE)
# ESRnom
ESRnomtable_20k <- ESR_resgenes_20k$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
ESRnomtable_20k %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in ESR nESRgenes_20k" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0032501 | multicellular organismal process | 2259 | 4504 | 1.68e-50 |
| GO:BP | GO:0048856 | anatomical structure development | 1964 | 3867 | 6.68e-46 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 1034 | 1844 | 9.73e-42 |
| GO:BP | GO:0007154 | cell communication | 1992 | 3983 | 9.85e-41 |
| GO:BP | GO:0023052 | signaling | 1962 | 3918 | 2.10e-40 |
| GO:BP | GO:0007275 | multicellular organism development | 1633 | 3170 | 2.57e-40 |
| GO:BP | GO:0032502 | developmental process | 2072 | 4179 | 6.91e-40 |
| GO:BP | GO:0048731 | system development | 1424 | 2719 | 1.37e-38 |
| GO:BP | GO:0050896 | response to stimulus | 2549 | 5379 | 2.99e-33 |
| GO:BP | GO:0030154 | cell differentiation | 1438 | 2803 | 6.60e-33 |
| GO:BP | GO:0007165 | signal transduction | 1794 | 3611 | 6.60e-33 |
| GO:BP | GO:0048869 | cellular developmental process | 1438 | 2804 | 7.71e-33 |
| GO:BP | GO:0051716 | cellular response to stimulus | 2225 | 4640 | 8.80e-31 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 1024 | 1924 | 4.99e-29 |
| GO:BP | GO:0007399 | nervous system development | 953 | 1775 | 1.85e-28 |
| GO:BP | GO:0007155 | cell adhesion | 553 | 941 | 2.52e-27 |
| GO:BP | GO:0048468 | cell development | 998 | 1886 | 5.84e-27 |
| GO:BP | GO:0009888 | tissue development | 746 | 1348 | 1.66e-26 |
| GO:BP | GO:0048513 | animal organ development | 1049 | 2004 | 2.68e-26 |
| GO:BP | GO:0050793 | regulation of developmental process | 899 | 1697 | 5.03e-24 |
| GO:BP | GO:0010646 | regulation of cell communication | 1236 | 2444 | 7.74e-24 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | 491 | 837 | 8.49e-24 |
| GO:BP | GO:0023051 | regulation of signaling | 1231 | 2438 | 2.18e-23 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | 943 | 1801 | 3.18e-23 |
| GO:BP | GO:0048870 | cell motility | 625 | 1120 | 5.48e-23 |
| GO:BP | GO:0003008 | system process | 633 | 1139 | 1.04e-22 |
| GO:BP | GO:0016477 | cell migration | 571 | 1011 | 1.80e-22 |
| GO:BP | GO:0022008 | neurogenesis | 684 | 1251 | 3.30e-22 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | 360 | 588 | 1.80e-21 |
| GO:BP | GO:0000902 | cell morphogenesis | 421 | 713 | 5.94e-21 |
| GO:BP | GO:0030029 | actin filament-based process | 384 | 640 | 1.02e-20 |
| GO:BP | GO:0034330 | cell junction organization | 336 | 545 | 1.10e-20 |
| GO:BP | GO:0048699 | generation of neurons | 594 | 1076 | 2.83e-20 |
| GO:BP | GO:0035239 | tube morphogenesis | 381 | 638 | 4.70e-20 |
| GO:BP | GO:0141124 | intracellular signaling cassette | 704 | 1314 | 7.30e-20 |
| GO:BP | GO:0050789 | regulation of biological process | 3343 | 7516 | 8.62e-20 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | 365 | 609 | 1.49e-19 |
| GO:BP | GO:0035295 | tube development | 452 | 787 | 2.39e-19 |
| GO:BP | GO:0030182 | neuron differentiation | 560 | 1014 | 4.37e-19 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | 416 | 717 | 8.67e-19 |
| GO:BP | GO:0031175 | neuron projection development | 428 | 743 | 1.40e-18 |
| GO:BP | GO:0009887 | animal organ morphogenesis | 392 | 673 | 4.88e-18 |
| GO:BP | GO:0007267 | cell-cell signaling | 588 | 1082 | 4.88e-18 |
| GO:BP | GO:0048666 | neuron development | 472 | 838 | 5.11e-18 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | 568 | 1040 | 5.36e-18 |
| GO:BP | GO:0065007 | biological regulation | 3418 | 7734 | 5.47e-18 |
| GO:BP | GO:0072359 | circulatory system development | 483 | 864 | 1.26e-17 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | 618 | 1150 | 1.28e-17 |
| GO:BP | GO:0120039 | plasma membrane bounded cell projection morphogenesis | 301 | 494 | 1.95e-17 |
| GO:BP | GO:0048858 | cell projection morphogenesis | 303 | 498 | 1.95e-17 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | 337 | 566 | 2.06e-17 |
| GO:BP | GO:0048729 | tissue morphogenesis | 280 | 453 | 2.16e-17 |
| GO:BP | GO:0050794 | regulation of cellular process | 3179 | 7153 | 3.02e-17 |
| GO:BP | GO:0030030 | cell projection organization | 631 | 1182 | 3.34e-17 |
| GO:BP | GO:0044057 | regulation of system process | 243 | 384 | 8.34e-17 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | 521 | 951 | 8.81e-17 |
| GO:BP | GO:0009966 | regulation of signal transduction | 1073 | 2166 | 1.71e-16 |
| GO:BP | GO:0065008 | regulation of biological quality | 951 | 1893 | 1.99e-16 |
| GO:BP | GO:0040011 | locomotion | 449 | 805 | 4.21e-16 |
| GO:BP | GO:0048812 | neuron projection morphogenesis | 289 | 479 | 6.47e-16 |
| GO:BP | GO:2000145 | regulation of cell motility | 396 | 700 | 2.18e-15 |
| GO:BP | GO:0035556 | intracellular signal transduction | 971 | 1951 | 2.43e-15 |
| GO:BP | GO:0048667 | cell morphogenesis involved in neuron differentiation | 265 | 435 | 2.80e-15 |
| GO:BP | GO:0051094 | positive regulation of developmental process | 497 | 913 | 2.86e-15 |
| GO:BP | GO:0001568 | blood vessel development | 310 | 525 | 2.86e-15 |
| GO:BP | GO:0030334 | regulation of cell migration | 380 | 668 | 2.87e-15 |
| GO:BP | GO:0048518 | positive regulation of biological process | 1986 | 4301 | 2.87e-15 |
| GO:BP | GO:0001944 | vasculature development | 323 | 552 | 3.52e-15 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 1838 | 3954 | 3.99e-15 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 1306 | 2717 | 4.82e-15 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 929 | 1862 | 5.69e-15 |
| GO:BP | GO:0040012 | regulation of locomotion | 403 | 720 | 1.04e-14 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 551 | 1035 | 1.49e-14 |
| GO:BP | GO:0003013 | circulatory system process | 258 | 426 | 1.85e-14 |
| GO:BP | GO:0048514 | blood vessel morphogenesis | 270 | 450 | 1.92e-14 |
| GO:BP | GO:0060485 | mesenchyme development | 164 | 245 | 2.02e-14 |
| GO:BP | GO:0120035 | regulation of plasma membrane bounded cell projection organization | 297 | 505 | 2.52e-14 |
| GO:BP | GO:0031344 | regulation of cell projection organization | 302 | 516 | 3.45e-14 |
| GO:BP | GO:0007010 | cytoskeleton organization | 599 | 1146 | 7.99e-14 |
| GO:BP | GO:0098609 | cell-cell adhesion | 324 | 564 | 1.03e-13 |
| GO:BP | GO:0034329 | cell junction assembly | 203 | 323 | 1.48e-13 |
| GO:BP | GO:0045595 | regulation of cell differentiation | 563 | 1073 | 2.56e-13 |
| GO:BP | GO:0048519 | negative regulation of biological process | 1743 | 3764 | 3.34e-13 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 619 | 1197 | 4.04e-13 |
| GO:BP | GO:0008015 | blood circulation | 219 | 357 | 4.97e-13 |
| GO:BP | GO:0060429 | epithelium development | 430 | 792 | 7.30e-13 |
| GO:BP | GO:0098657 | import into cell | 349 | 622 | 7.61e-13 |
| GO:BP | GO:0030001 | metal ion transport | 301 | 524 | 1.07e-12 |
| GO:BP | GO:0010975 | regulation of neuron projection development | 217 | 355 | 1.10e-12 |
| GO:BP | GO:0030155 | regulation of cell adhesion | 293 | 508 | 1.19e-12 |
| GO:BP | GO:0051049 | regulation of transport | 571 | 1098 | 1.34e-12 |
| GO:BP | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 267 | 456 | 1.60e-12 |
| GO:BP | GO:0003012 | muscle system process | 201 | 325 | 1.96e-12 |
| GO:BP | GO:0070848 | response to growth factor | 310 | 547 | 4.47e-12 |
| GO:BP | GO:0009790 | embryo development | 440 | 821 | 5.10e-12 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | 300 | 528 | 7.44e-12 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 1641 | 3550 | 8.41e-12 |
| GO:BP | GO:0007409 | axonogenesis | 205 | 337 | 1.12e-11 |
| GO:BP | GO:0002009 | morphogenesis of an epithelium | 221 | 369 | 1.22e-11 |
| GO:BP | GO:0031589 | cell-substrate adhesion | 164 | 258 | 1.71e-11 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | 329 | 591 | 1.72e-11 |
| GO:BP | GO:0051960 | regulation of nervous system development | 205 | 339 | 2.48e-11 |
| GO:BP | GO:0048762 | mesenchymal cell differentiation | 133 | 200 | 2.48e-11 |
| GO:BP | GO:0001525 | angiogenesis | 226 | 381 | 2.51e-11 |
| GO:BP | GO:0150115 | cell-substrate junction organization | 74 | 95 | 2.51e-11 |
| GO:BP | GO:0042221 | response to chemical | 1100 | 2304 | 3.45e-11 |
| GO:BP | GO:0007264 | small GTPase-mediated signal transduction | 230 | 390 | 3.54e-11 |
| GO:BP | GO:0061564 | axon development | 221 | 372 | 3.60e-11 |
| GO:BP | GO:0010810 | regulation of cell-substrate adhesion | 112 | 162 | 3.60e-11 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | 406 | 757 | 4.04e-11 |
| GO:BP | GO:0048589 | developmental growth | 284 | 501 | 4.53e-11 |
| GO:BP | GO:0048598 | embryonic morphogenesis | 245 | 422 | 6.14e-11 |
| GO:BP | GO:0061061 | muscle structure development | 300 | 536 | 7.98e-11 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | 69 | 88 | 8.49e-11 |
| GO:BP | GO:0070588 | calcium ion transmembrane transport | 137 | 210 | 8.88e-11 |
| GO:BP | GO:0051241 | negative regulation of multicellular organismal process | 380 | 706 | 1.21e-10 |
| GO:BP | GO:0006936 | muscle contraction | 160 | 255 | 1.42e-10 |
| GO:BP | GO:0007186 | G protein-coupled receptor signaling pathway | 226 | 386 | 1.45e-10 |
| GO:BP | GO:0006816 | calcium ion transport | 163 | 262 | 2.41e-10 |
| GO:BP | GO:0051056 | regulation of small GTPase mediated signal transduction | 148 | 233 | 2.42e-10 |
| GO:BP | GO:0034762 | regulation of transmembrane transport | 181 | 298 | 3.17e-10 |
| GO:BP | GO:0010647 | positive regulation of cell communication | 613 | 1218 | 3.24e-10 |
| GO:BP | GO:0023056 | positive regulation of signaling | 614 | 1221 | 3.73e-10 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | 265 | 469 | 4.14e-10 |
| GO:BP | GO:0023057 | negative regulation of signaling | 529 | 1036 | 6.12e-10 |
| GO:BP | GO:0099536 | synaptic signaling | 271 | 483 | 6.68e-10 |
| GO:BP | GO:0001667 | ameboidal-type cell migration | 203 | 344 | 6.95e-10 |
| GO:BP | GO:0050804 | modulation of chemical synaptic transmission | 192 | 322 | 7.08e-10 |
| GO:BP | GO:1901888 | regulation of cell junction assembly | 106 | 156 | 7.21e-10 |
| GO:BP | GO:0016043 | cellular component organization | 2151 | 4802 | 7.49e-10 |
| GO:BP | GO:0099537 | trans-synaptic signaling | 263 | 467 | 7.71e-10 |
| GO:BP | GO:0006810 | transport | 1383 | 2984 | 7.86e-10 |
| GO:BP | GO:0010648 | negative regulation of cell communication | 527 | 1034 | 9.38e-10 |
| GO:BP | GO:0050808 | synapse organization | 199 | 337 | 9.77e-10 |
| GO:BP | GO:0099177 | regulation of trans-synaptic signaling | 192 | 323 | 9.90e-10 |
| GO:BP | GO:0098660 | inorganic ion transmembrane transport | 288 | 521 | 1.34e-09 |
| GO:BP | GO:0006897 | endocytosis | 274 | 492 | 1.43e-09 |
| GO:BP | GO:0007268 | chemical synaptic transmission | 260 | 463 | 1.45e-09 |
| GO:BP | GO:0098916 | anterograde trans-synaptic signaling | 260 | 463 | 1.45e-09 |
| GO:BP | GO:0006468 | protein phosphorylation | 491 | 958 | 1.65e-09 |
| GO:BP | GO:0060560 | developmental growth involved in morphogenesis | 123 | 190 | 2.31e-09 |
| GO:BP | GO:0097435 | supramolecular fiber organization | 340 | 633 | 2.31e-09 |
| GO:BP | GO:0032879 | regulation of localization | 706 | 1439 | 2.98e-09 |
| GO:BP | GO:0007423 | sensory organ development | 222 | 387 | 2.98e-09 |
| GO:BP | GO:0007507 | heart development | 276 | 499 | 3.11e-09 |
| GO:BP | GO:0048041 | focal adhesion assembly | 60 | 77 | 3.36e-09 |
| GO:BP | GO:0007411 | axon guidance | 113 | 172 | 3.57e-09 |
| GO:BP | GO:0097485 | neuron projection guidance | 113 | 172 | 3.57e-09 |
| GO:BP | GO:0048568 | embryonic organ development | 180 | 303 | 4.25e-09 |
| GO:BP | GO:0010720 | positive regulation of cell development | 183 | 309 | 4.25e-09 |
| GO:BP | GO:0140352 | export from cell | 320 | 594 | 5.44e-09 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | 637 | 1289 | 6.34e-09 |
| GO:BP | GO:2000147 | positive regulation of cell motility | 231 | 408 | 6.36e-09 |
| GO:BP | GO:0010959 | regulation of metal ion transport | 147 | 239 | 7.52e-09 |
| GO:BP | GO:0034220 | monoatomic ion transmembrane transport | 316 | 587 | 7.84e-09 |
| GO:BP | GO:0060562 | epithelial tube morphogenesis | 158 | 261 | 8.50e-09 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | 593 | 1193 | 9.14e-09 |
| GO:BP | GO:0030335 | positive regulation of cell migration | 224 | 395 | 9.76e-09 |
| GO:BP | GO:0006811 | monoatomic ion transport | 377 | 719 | 1.04e-08 |
| GO:BP | GO:0040017 | positive regulation of locomotion | 234 | 416 | 1.07e-08 |
| GO:BP | GO:0016310 | phosphorylation | 571 | 1145 | 1.07e-08 |
| GO:BP | GO:0008283 | cell population proliferation | 643 | 1306 | 1.09e-08 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | 151 | 248 | 1.15e-08 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | 437 | 850 | 1.17e-08 |
| GO:BP | GO:0050767 | regulation of neurogenesis | 172 | 290 | 1.24e-08 |
| GO:BP | GO:0014706 | striated muscle tissue development | 133 | 213 | 1.26e-08 |
| GO:BP | GO:0060284 | regulation of cell development | 307 | 570 | 1.26e-08 |
| GO:BP | GO:0007015 | actin filament organization | 205 | 357 | 1.28e-08 |
| GO:BP | GO:0099003 | vesicle-mediated transport in synapse | 110 | 169 | 1.32e-08 |
| GO:BP | GO:0051179 | localization | 1689 | 3731 | 1.39e-08 |
| GO:BP | GO:1903522 | regulation of blood circulation | 123 | 194 | 1.44e-08 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | 492 | 972 | 1.44e-08 |
| GO:BP | GO:0098655 | monoatomic cation transmembrane transport | 271 | 495 | 1.66e-08 |
| GO:BP | GO:0007417 | central nervous system development | 364 | 694 | 1.93e-08 |
| GO:BP | GO:0009605 | response to external stimulus | 753 | 1559 | 2.23e-08 |
| GO:BP | GO:0060322 | head development | 291 | 539 | 2.61e-08 |
| GO:BP | GO:0098662 | inorganic cation transmembrane transport | 263 | 480 | 2.70e-08 |
| GO:BP | GO:0055085 | transmembrane transport | 467 | 921 | 3.09e-08 |
| GO:BP | GO:0060047 | heart contraction | 122 | 194 | 3.48e-08 |
| GO:BP | GO:0050877 | nervous system process | 319 | 600 | 3.57e-08 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | 537 | 1077 | 3.74e-08 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | 544 | 1093 | 4.02e-08 |
| GO:BP | GO:0046903 | secretion | 329 | 622 | 4.02e-08 |
| GO:BP | GO:0048588 | developmental cell growth | 114 | 179 | 4.13e-08 |
| GO:BP | GO:0043269 | regulation of monoatomic ion transport | 166 | 282 | 5.13e-08 |
| GO:BP | GO:0007420 | brain development | 270 | 498 | 6.22e-08 |
| GO:BP | GO:0006812 | monoatomic cation transport | 324 | 614 | 7.54e-08 |
| GO:BP | GO:1904062 | regulation of monoatomic cation transmembrane transport | 118 | 188 | 7.54e-08 |
| GO:BP | GO:0097553 | calcium ion transmembrane import into cytosol | 83 | 122 | 8.32e-08 |
| GO:BP | GO:0007160 | cell-matrix adhesion | 108 | 169 | 8.44e-08 |
| GO:BP | GO:0003015 | heart process | 126 | 204 | 8.99e-08 |
| GO:BP | GO:0009611 | response to wounding | 214 | 382 | 8.99e-08 |
| GO:BP | GO:0034765 | regulation of monoatomic ion transmembrane transport | 129 | 210 | 9.44e-08 |
| GO:BP | GO:0060537 | muscle tissue development | 193 | 339 | 9.98e-08 |
| GO:BP | GO:0031346 | positive regulation of cell projection organization | 167 | 286 | 1.01e-07 |
| GO:BP | GO:0042391 | regulation of membrane potential | 165 | 282 | 1.01e-07 |
| GO:BP | GO:0045229 | external encapsulating structure organization | 136 | 224 | 1.01e-07 |
| GO:BP | GO:0043062 | extracellular structure organization | 136 | 224 | 1.01e-07 |
| GO:BP | GO:0051093 | negative regulation of developmental process | 327 | 622 | 1.02e-07 |
| GO:BP | GO:0042692 | muscle cell differentiation | 185 | 323 | 1.11e-07 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | 124 | 201 | 1.29e-07 |
| GO:BP | GO:0030198 | extracellular matrix organization | 135 | 223 | 1.48e-07 |
| GO:BP | GO:0051234 | establishment of localization | 1471 | 3240 | 1.50e-07 |
| GO:BP | GO:0007610 | behavior | 231 | 420 | 1.78e-07 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | 830 | 1751 | 2.03e-07 |
| GO:BP | GO:0030900 | forebrain development | 159 | 272 | 2.10e-07 |
| GO:BP | GO:0003007 | heart morphogenesis | 132 | 218 | 2.13e-07 |
| GO:BP | GO:0090109 | regulation of cell-substrate junction assembly | 44 | 55 | 2.17e-07 |
| GO:BP | GO:0051893 | regulation of focal adhesion assembly | 44 | 55 | 2.17e-07 |
| GO:BP | GO:0150116 | regulation of cell-substrate junction organization | 47 | 60 | 2.28e-07 |
| GO:BP | GO:0044089 | positive regulation of cellular component biogenesis | 216 | 390 | 2.56e-07 |
| GO:BP | GO:0009792 | embryo development ending in birth or egg hatching | 278 | 521 | 2.56e-07 |
| GO:BP | GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 77 | 113 | 2.60e-07 |
| GO:BP | GO:0048638 | regulation of developmental growth | 144 | 243 | 3.18e-07 |
| GO:BP | GO:0040007 | growth | 359 | 697 | 3.30e-07 |
| GO:BP | GO:0001952 | regulation of cell-matrix adhesion | 64 | 90 | 3.70e-07 |
| GO:BP | GO:0003018 | vascular process in circulatory system | 119 | 194 | 4.07e-07 |
| GO:BP | GO:0098771 | inorganic ion homeostasis | 195 | 348 | 4.15e-07 |
| GO:BP | GO:0023061 | signal release | 179 | 315 | 4.18e-07 |
| GO:BP | GO:0032940 | secretion by cell | 291 | 551 | 4.18e-07 |
| GO:BP | GO:0008016 | regulation of heart contraction | 104 | 165 | 4.41e-07 |
| GO:BP | GO:0001775 | cell activation | 326 | 627 | 4.63e-07 |
| GO:BP | GO:0045785 | positive regulation of cell adhesion | 172 | 301 | 4.66e-07 |
| GO:BP | GO:0090257 | regulation of muscle system process | 110 | 177 | 5.15e-07 |
| GO:BP | GO:0043009 | chordate embryonic development | 270 | 507 | 5.17e-07 |
| GO:BP | GO:0044093 | positive regulation of molecular function | 397 | 783 | 5.55e-07 |
| GO:BP | GO:0030048 | actin filament-based movement | 73 | 107 | 5.64e-07 |
| GO:BP | GO:0001837 | epithelial to mesenchymal transition | 89 | 137 | 6.08e-07 |
| GO:BP | GO:0065009 | regulation of molecular function | 627 | 1299 | 7.82e-07 |
| GO:BP | GO:0003205 | cardiac chamber development | 96 | 151 | 8.38e-07 |
| GO:BP | GO:0051924 | regulation of calcium ion transport | 97 | 153 | 8.67e-07 |
| GO:BP | GO:0051146 | striated muscle cell differentiation | 138 | 234 | 9.29e-07 |
| GO:BP | GO:0051962 | positive regulation of nervous system development | 127 | 212 | 9.33e-07 |
| GO:BP | GO:0003206 | cardiac chamber morphogenesis | 74 | 110 | 1.11e-06 |
| GO:BP | GO:0090596 | sensory organ morphogenesis | 107 | 173 | 1.13e-06 |
| GO:BP | GO:0050770 | regulation of axonogenesis | 82 | 125 | 1.13e-06 |
| GO:BP | GO:0001823 | mesonephros development | 54 | 74 | 1.19e-06 |
| GO:BP | GO:0006915 | apoptotic process | 660 | 1377 | 1.19e-06 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | 715 | 1504 | 1.51e-06 |
| GO:BP | GO:0071310 | cellular response to organic substance | 624 | 1297 | 1.51e-06 |
| GO:BP | GO:0010033 | response to organic substance | 816 | 1736 | 1.62e-06 |
| GO:BP | GO:0006935 | chemotaxis | 142 | 244 | 1.78e-06 |
| GO:BP | GO:0042330 | taxis | 142 | 244 | 1.78e-06 |
| GO:BP | GO:0042060 | wound healing | 165 | 291 | 1.78e-06 |
| GO:BP | GO:0001501 | skeletal system development | 192 | 347 | 1.78e-06 |
| GO:BP | GO:0071417 | cellular response to organonitrogen compound | 237 | 442 | 1.80e-06 |
| GO:BP | GO:0099504 | synaptic vesicle cycle | 95 | 151 | 1.98e-06 |
| GO:BP | GO:0072164 | mesonephric tubule development | 53 | 73 | 2.05e-06 |
| GO:BP | GO:0072163 | mesonephric epithelium development | 53 | 73 | 2.05e-06 |
| GO:BP | GO:0001654 | eye development | 151 | 263 | 2.20e-06 |
| GO:BP | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 161 | 284 | 2.57e-06 |
| GO:BP | GO:0016358 | dendrite development | 111 | 183 | 2.65e-06 |
| GO:BP | GO:1903169 | regulation of calcium ion transmembrane transport | 72 | 108 | 2.81e-06 |
| GO:BP | GO:0048880 | sensory system development | 152 | 266 | 2.98e-06 |
| GO:BP | GO:0150063 | visual system development | 151 | 264 | 3.02e-06 |
| GO:BP | GO:0035265 | organ growth | 82 | 127 | 3.04e-06 |
| GO:BP | GO:0033002 | muscle cell proliferation | 95 | 152 | 3.04e-06 |
| GO:BP | GO:0090066 | regulation of anatomical structure size | 206 | 379 | 3.48e-06 |
| GO:BP | GO:0001657 | ureteric bud development | 52 | 72 | 3.52e-06 |
| GO:BP | GO:0050803 | regulation of synapse structure or activity | 107 | 176 | 3.75e-06 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 2188 | 4988 | 3.78e-06 |
| GO:BP | GO:0071773 | cellular response to BMP stimulus | 77 | 118 | 3.81e-06 |
| GO:BP | GO:0071772 | response to BMP | 77 | 118 | 3.81e-06 |
| GO:BP | GO:0031032 | actomyosin structure organization | 111 | 184 | 3.82e-06 |
| GO:BP | GO:0008219 | cell death | 676 | 1423 | 4.02e-06 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 1105 | 2415 | 4.06e-06 |
| GO:BP | GO:0001763 | morphogenesis of a branching structure | 91 | 145 | 4.15e-06 |
| GO:BP | GO:0031345 | negative regulation of cell projection organization | 91 | 145 | 4.15e-06 |
| GO:BP | GO:0043410 | positive regulation of MAPK cascade | 162 | 288 | 4.43e-06 |
| GO:BP | GO:0006937 | regulation of muscle contraction | 81 | 126 | 4.59e-06 |
| GO:BP | GO:0010717 | regulation of epithelial to mesenchymal transition | 59 | 85 | 4.65e-06 |
| GO:BP | GO:0040013 | negative regulation of locomotion | 140 | 243 | 4.67e-06 |
| GO:BP | GO:0050807 | regulation of synapse organization | 105 | 173 | 5.31e-06 |
| GO:BP | GO:1990138 | neuron projection extension | 85 | 134 | 5.36e-06 |
| GO:BP | GO:0061448 | connective tissue development | 121 | 205 | 5.48e-06 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | 1192 | 2622 | 5.52e-06 |
| GO:BP | GO:0012501 | programmed cell death | 673 | 1419 | 5.62e-06 |
| GO:BP | GO:0048639 | positive regulation of developmental growth | 77 | 119 | 6.13e-06 |
| GO:BP | GO:0006941 | striated muscle contraction | 91 | 146 | 6.34e-06 |
| GO:BP | GO:0051050 | positive regulation of transport | 294 | 571 | 6.66e-06 |
| GO:BP | GO:0014070 | response to organic cyclic compound | 310 | 606 | 6.78e-06 |
| GO:BP | GO:0010243 | response to organonitrogen compound | 346 | 685 | 6.80e-06 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | 167 | 300 | 6.91e-06 |
| GO:BP | GO:0055074 | calcium ion homeostasis | 126 | 216 | 7.43e-06 |
| GO:BP | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 53 | 75 | 7.75e-06 |
| GO:BP | GO:0006874 | intracellular calcium ion homeostasis | 119 | 202 | 7.75e-06 |
| GO:BP | GO:0050769 | positive regulation of neurogenesis | 110 | 184 | 7.79e-06 |
| GO:BP | GO:0010632 | regulation of epithelial cell migration | 112 | 188 | 7.79e-06 |
| GO:BP | GO:0061138 | morphogenesis of a branching epithelium | 85 | 135 | 8.23e-06 |
| GO:BP | GO:0090130 | tissue migration | 141 | 247 | 8.45e-06 |
| GO:BP | GO:0022898 | regulation of transmembrane transporter activity | 87 | 139 | 8.65e-06 |
| GO:BP | GO:0048167 | regulation of synaptic plasticity | 87 | 139 | 8.65e-06 |
| GO:BP | GO:0099173 | postsynapse organization | 91 | 147 | 9.51e-06 |
| GO:BP | GO:0045165 | cell fate commitment | 93 | 151 | 9.85e-06 |
| GO:BP | GO:0051283 | negative regulation of sequestering of calcium ion | 61 | 90 | 1.00e-05 |
| GO:BP | GO:0055001 | muscle cell development | 99 | 163 | 1.06e-05 |
| GO:BP | GO:1905314 | semi-lunar valve development | 33 | 41 | 1.10e-05 |
| GO:BP | GO:0022604 | regulation of cell morphogenesis | 114 | 193 | 1.10e-05 |
| GO:BP | GO:0072001 | renal system development | 139 | 244 | 1.18e-05 |
| GO:BP | GO:0061572 | actin filament bundle organization | 83 | 132 | 1.20e-05 |
| GO:BP | GO:0072073 | kidney epithelium development | 72 | 111 | 1.24e-05 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | 250 | 479 | 1.29e-05 |
| GO:BP | GO:0003231 | cardiac ventricle development | 74 | 115 | 1.36e-05 |
| GO:BP | GO:0032409 | regulation of transporter activity | 91 | 148 | 1.43e-05 |
| GO:BP | GO:0060395 | SMAD protein signal transduction | 53 | 76 | 1.45e-05 |
| GO:BP | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 122 | 210 | 1.45e-05 |
| GO:BP | GO:1901698 | response to nitrogen compound | 367 | 736 | 1.45e-05 |
| GO:BP | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 93 | 152 | 1.45e-05 |
| GO:BP | GO:0070252 | actin-mediated cell contraction | 59 | 87 | 1.45e-05 |
| GO:BP | GO:0042472 | inner ear morphogenesis | 44 | 60 | 1.45e-05 |
| GO:BP | GO:0030855 | epithelial cell differentiation | 226 | 428 | 1.46e-05 |
| GO:BP | GO:0010631 | epithelial cell migration | 138 | 243 | 1.58e-05 |
| GO:BP | GO:0090132 | epithelium migration | 138 | 243 | 1.58e-05 |
| GO:BP | GO:0051209 | release of sequestered calcium ion into cytosol | 60 | 89 | 1.58e-05 |
| GO:BP | GO:0045321 | leukocyte activation | 273 | 530 | 1.58e-05 |
| GO:BP | GO:0003179 | heart valve morphogenesis | 41 | 55 | 1.70e-05 |
| GO:BP | GO:0051336 | regulation of hydrolase activity | 227 | 431 | 1.75e-05 |
| GO:BP | GO:0051017 | actin filament bundle assembly | 82 | 131 | 1.75e-05 |
| GO:BP | GO:0050878 | regulation of body fluid levels | 131 | 229 | 1.75e-05 |
| GO:BP | GO:0060419 | heart growth | 50 | 71 | 1.83e-05 |
| GO:BP | GO:0030509 | BMP signaling pathway | 71 | 110 | 1.86e-05 |
| GO:BP | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 38 | 50 | 1.91e-05 |
| GO:BP | GO:0051216 | cartilage development | 89 | 145 | 2.01e-05 |
| GO:BP | GO:0060048 | cardiac muscle contraction | 74 | 116 | 2.12e-05 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | 108 | 183 | 2.19e-05 |
| GO:BP | GO:0090288 | negative regulation of cellular response to growth factor stimulus | 52 | 75 | 2.33e-05 |
| GO:BP | GO:0043010 | camera-type eye development | 131 | 230 | 2.38e-05 |
| GO:BP | GO:0051046 | regulation of secretion | 210 | 396 | 2.38e-05 |
| GO:BP | GO:0002062 | chondrocyte differentiation | 59 | 88 | 2.50e-05 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | 241 | 463 | 2.53e-05 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | 241 | 463 | 2.53e-05 |
| GO:BP | GO:0031325 | positive regulation of cellular metabolic process | 1061 | 2333 | 2.77e-05 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | 283 | 555 | 2.87e-05 |
| GO:BP | GO:0009987 | cellular process | 4477 | 10686 | 2.87e-05 |
| GO:BP | GO:0051282 | regulation of sequestering of calcium ion | 61 | 92 | 2.87e-05 |
| GO:BP | GO:1902533 | positive regulation of intracellular signal transduction | 355 | 714 | 2.98e-05 |
| GO:BP | GO:0045216 | cell-cell junction organization | 92 | 152 | 3.05e-05 |
| GO:BP | GO:0042592 | homeostatic process | 543 | 1137 | 3.10e-05 |
| GO:BP | GO:0048878 | chemical homeostasis | 335 | 670 | 3.13e-05 |
| GO:BP | GO:0072006 | nephron development | 73 | 115 | 3.18e-05 |
| GO:BP | GO:0060976 | coronary vasculature development | 34 | 44 | 3.70e-05 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | 523 | 1093 | 3.73e-05 |
| GO:BP | GO:0003279 | cardiac septum development | 66 | 102 | 3.83e-05 |
| GO:BP | GO:0021915 | neural tube development | 82 | 133 | 4.02e-05 |
| GO:BP | GO:1901890 | positive regulation of cell junction assembly | 52 | 76 | 4.19e-05 |
| GO:BP | GO:0048844 | artery morphogenesis | 42 | 58 | 4.23e-05 |
| GO:BP | GO:0002521 | leukocyte differentiation | 197 | 371 | 4.38e-05 |
| GO:BP | GO:0003151 | outflow tract morphogenesis | 47 | 67 | 4.38e-05 |
| GO:BP | GO:0060411 | cardiac septum morphogenesis | 47 | 67 | 4.38e-05 |
| GO:BP | GO:2000181 | negative regulation of blood vessel morphogenesis | 47 | 67 | 4.38e-05 |
| GO:BP | GO:0015833 | peptide transport | 105 | 179 | 4.38e-05 |
| GO:BP | GO:1901343 | negative regulation of vasculature development | 47 | 67 | 4.38e-05 |
| GO:BP | GO:0030510 | regulation of BMP signaling pathway | 53 | 78 | 4.52e-05 |
| GO:BP | GO:0060078 | regulation of postsynaptic membrane potential | 53 | 78 | 4.52e-05 |
| GO:BP | GO:0001822 | kidney development | 133 | 237 | 5.47e-05 |
| GO:BP | GO:1901342 | regulation of vasculature development | 114 | 198 | 5.56e-05 |
| GO:BP | GO:0030100 | regulation of endocytosis | 113 | 196 | 5.62e-05 |
| GO:BP | GO:0045765 | regulation of angiogenesis | 112 | 194 | 5.67e-05 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | 234 | 452 | 5.77e-05 |
| GO:BP | GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 82 | 134 | 5.93e-05 |
| GO:BP | GO:0051058 | negative regulation of small GTPase mediated signal transduction | 36 | 48 | 5.93e-05 |
| GO:BP | GO:0055008 | cardiac muscle tissue morphogenesis | 40 | 55 | 6.05e-05 |
| GO:BP | GO:0018212 | peptidyl-tyrosine modification | 97 | 164 | 6.31e-05 |
| GO:BP | GO:0009612 | response to mechanical stimulus | 91 | 152 | 6.31e-05 |
| GO:BP | GO:0048644 | muscle organ morphogenesis | 45 | 64 | 6.39e-05 |
| GO:BP | GO:0055017 | cardiac muscle tissue growth | 45 | 64 | 6.39e-05 |
| GO:BP | GO:0060038 | cardiac muscle cell proliferation | 33 | 43 | 6.54e-05 |
| GO:BP | GO:0048168 | regulation of neuronal synaptic plasticity | 30 | 38 | 6.72e-05 |
| GO:BP | GO:0009628 | response to abiotic stimulus | 396 | 811 | 6.72e-05 |
| GO:BP | GO:0006949 | syncytium formation | 30 | 38 | 6.72e-05 |
| GO:BP | GO:0043408 | regulation of MAPK cascade | 222 | 427 | 6.89e-05 |
| GO:BP | GO:0007389 | pattern specification process | 156 | 286 | 6.89e-05 |
| GO:BP | GO:0048813 | dendrite morphogenesis | 70 | 111 | 6.89e-05 |
| GO:BP | GO:0048771 | tissue remodeling | 71 | 113 | 7.06e-05 |
| GO:BP | GO:0016525 | negative regulation of angiogenesis | 46 | 66 | 7.11e-05 |
| GO:BP | GO:0061035 | regulation of cartilage development | 37 | 50 | 7.12e-05 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | 144 | 261 | 7.16e-05 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | 143 | 259 | 7.33e-05 |
| GO:BP | GO:0050801 | monoatomic ion homeostasis | 212 | 406 | 7.75e-05 |
| GO:BP | GO:0007611 | learning or memory | 109 | 189 | 7.84e-05 |
| GO:BP | GO:2000027 | regulation of animal organ morphogenesis | 42 | 59 | 8.04e-05 |
| GO:BP | GO:0010634 | positive regulation of epithelial cell migration | 78 | 127 | 8.12e-05 |
| GO:BP | GO:0006813 | potassium ion transport | 82 | 135 | 8.51e-05 |
| GO:BP | GO:0006836 | neurotransmitter transport | 82 | 135 | 8.51e-05 |
| GO:BP | GO:0046632 | alpha-beta T cell differentiation | 48 | 70 | 8.73e-05 |
| GO:BP | GO:0043491 | phosphatidylinositol 3-kinase/protein kinase B signal transduction | 121 | 214 | 8.82e-05 |
| GO:BP | GO:0060415 | muscle tissue morphogenesis | 43 | 61 | 9.17e-05 |
| GO:BP | GO:0060840 | artery development | 56 | 85 | 9.45e-05 |
| GO:BP | GO:0050806 | positive regulation of synaptic transmission | 67 | 106 | 9.62e-05 |
| GO:BP | GO:0046879 | hormone secretion | 115 | 202 | 9.75e-05 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | 862 | 1883 | 1.02e-04 |
| GO:BP | GO:0055080 | monoatomic cation homeostasis | 209 | 401 | 1.04e-04 |
| GO:BP | GO:0031644 | regulation of nervous system process | 50 | 74 | 1.04e-04 |
| GO:BP | GO:0045927 | positive regulation of growth | 106 | 184 | 1.11e-04 |
| GO:BP | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 59 | 91 | 1.11e-04 |
| GO:BP | GO:0048562 | embryonic organ morphogenesis | 105 | 182 | 1.12e-04 |
| GO:BP | GO:0006898 | receptor-mediated endocytosis | 105 | 182 | 1.12e-04 |
| GO:BP | GO:0071805 | potassium ion transmembrane transport | 74 | 120 | 1.13e-04 |
| GO:BP | GO:0007517 | muscle organ development | 146 | 267 | 1.13e-04 |
| GO:BP | GO:2000146 | negative regulation of cell motility | 122 | 217 | 1.14e-04 |
| GO:BP | GO:0003170 | heart valve development | 45 | 65 | 1.14e-04 |
| GO:BP | GO:0022612 | gland morphogenesis | 60 | 93 | 1.15e-04 |
| GO:BP | GO:0003176 | aortic valve development | 29 | 37 | 1.19e-04 |
| GO:BP | GO:0002790 | peptide secretion | 97 | 166 | 1.19e-04 |
| GO:BP | GO:0035725 | sodium ion transmembrane transport | 61 | 95 | 1.19e-04 |
| GO:BP | GO:0010811 | positive regulation of cell-substrate adhesion | 61 | 95 | 1.19e-04 |
| GO:BP | GO:0018108 | peptidyl-tyrosine phosphorylation | 95 | 162 | 1.20e-04 |
| GO:BP | GO:0043085 | positive regulation of catalytic activity | 275 | 546 | 1.21e-04 |
| GO:BP | GO:0006793 | phosphorus metabolic process | 870 | 1904 | 1.23e-04 |
| GO:BP | GO:0009914 | hormone transport | 117 | 207 | 1.23e-04 |
| GO:BP | GO:0072028 | nephron morphogenesis | 41 | 58 | 1.31e-04 |
| GO:BP | GO:0051235 | maintenance of location | 138 | 251 | 1.36e-04 |
| GO:BP | GO:0001934 | positive regulation of protein phosphorylation | 206 | 396 | 1.37e-04 |
| GO:BP | GO:0006939 | smooth muscle contraction | 47 | 69 | 1.37e-04 |
| GO:BP | GO:0003281 | ventricular septum development | 47 | 69 | 1.37e-04 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | 318 | 642 | 1.38e-04 |
| GO:BP | GO:0072132 | mesenchyme morphogenesis | 37 | 51 | 1.41e-04 |
| GO:BP | GO:0048754 | branching morphogenesis of an epithelial tube | 70 | 113 | 1.55e-04 |
| GO:BP | GO:0030336 | negative regulation of cell migration | 118 | 210 | 1.62e-04 |
| GO:BP | GO:0003208 | cardiac ventricle morphogenesis | 43 | 62 | 1.66e-04 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | 848 | 1856 | 1.66e-04 |
| GO:BP | GO:0019722 | calcium-mediated signaling | 75 | 123 | 1.67e-04 |
| GO:BP | GO:0010628 | positive regulation of gene expression | 364 | 746 | 1.68e-04 |
| GO:BP | GO:0043270 | positive regulation of monoatomic ion transport | 77 | 127 | 1.69e-04 |
| GO:BP | GO:0016049 | cell growth | 199 | 382 | 1.71e-04 |
| GO:BP | GO:0006814 | sodium ion transport | 82 | 137 | 1.73e-04 |
| GO:BP | GO:0016192 | vesicle-mediated transport | 543 | 1152 | 1.75e-04 |
| GO:BP | GO:0051208 | sequestering of calcium ion | 61 | 96 | 1.87e-04 |
| GO:BP | GO:0060627 | regulation of vesicle-mediated transport | 195 | 374 | 1.95e-04 |
| GO:BP | GO:0198738 | cell-cell signaling by wnt | 188 | 359 | 1.98e-04 |
| GO:BP | GO:0050919 | negative chemotaxis | 31 | 41 | 1.98e-04 |
| GO:BP | GO:0140253 | cell-cell fusion | 28 | 36 | 2.15e-04 |
| GO:BP | GO:0000768 | syncytium formation by plasma membrane fusion | 28 | 36 | 2.15e-04 |
| GO:BP | GO:0060993 | kidney morphogenesis | 46 | 68 | 2.20e-04 |
| GO:BP | GO:0043087 | regulation of GTPase activity | 96 | 166 | 2.28e-04 |
| GO:BP | GO:1902414 | protein localization to cell junction | 55 | 85 | 2.33e-04 |
| GO:BP | GO:0061337 | cardiac conduction | 55 | 85 | 2.33e-04 |
| GO:BP | GO:0098659 | inorganic cation import across plasma membrane | 47 | 70 | 2.37e-04 |
| GO:BP | GO:0099587 | inorganic ion import across plasma membrane | 47 | 70 | 2.37e-04 |
| GO:BP | GO:0099565 | chemical synaptic transmission, postsynaptic | 47 | 70 | 2.37e-04 |
| GO:BP | GO:0031399 | regulation of protein modification process | 436 | 911 | 2.38e-04 |
| GO:BP | GO:0016331 | morphogenesis of embryonic epithelium | 74 | 122 | 2.40e-04 |
| GO:BP | GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 41 | 59 | 2.41e-04 |
| GO:BP | GO:0007613 | memory | 56 | 87 | 2.41e-04 |
| GO:BP | GO:0071526 | semaphorin-plexin signaling pathway | 32 | 43 | 2.42e-04 |
| GO:BP | GO:0060348 | bone development | 86 | 146 | 2.42e-04 |
| GO:BP | GO:0007369 | gastrulation | 83 | 140 | 2.44e-04 |
| GO:BP | GO:0021537 | telencephalon development | 110 | 195 | 2.44e-04 |
| GO:BP | GO:0016055 | Wnt signaling pathway | 187 | 358 | 2.47e-04 |
| GO:BP | GO:0048863 | stem cell differentiation | 108 | 191 | 2.53e-04 |
| GO:BP | GO:0031328 | positive regulation of cellular biosynthetic process | 839 | 1841 | 2.80e-04 |
| GO:BP | GO:0048660 | regulation of smooth muscle cell proliferation | 61 | 97 | 2.87e-04 |
| GO:BP | GO:0003180 | aortic valve morphogenesis | 26 | 33 | 2.90e-04 |
| GO:BP | GO:0060675 | ureteric bud morphogenesis | 33 | 45 | 2.91e-04 |
| GO:BP | GO:0042886 | amide transport | 114 | 204 | 3.01e-04 |
| GO:BP | GO:0051173 | positive regulation of nitrogen compound metabolic process | 986 | 2186 | 3.07e-04 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | 817 | 1791 | 3.13e-04 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | 435 | 911 | 3.13e-04 |
| GO:BP | GO:0035023 | regulation of Rho protein signal transduction | 44 | 65 | 3.19e-04 |
| GO:BP | GO:0010977 | negative regulation of neuron projection development | 67 | 109 | 3.24e-04 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | 384 | 796 | 3.28e-04 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | 274 | 550 | 3.29e-04 |
| GO:BP | GO:1903530 | regulation of secretion by cell | 190 | 366 | 3.34e-04 |
| GO:BP | GO:0071407 | cellular response to organic cyclic compound | 196 | 379 | 3.34e-04 |
| GO:BP | GO:2001257 | regulation of cation channel activity | 45 | 67 | 3.44e-04 |
| GO:BP | GO:0072088 | nephron epithelium morphogenesis | 39 | 56 | 3.49e-04 |
| GO:BP | GO:0000165 | MAPK cascade | 253 | 504 | 3.50e-04 |
| GO:BP | GO:0050890 | cognition | 118 | 213 | 3.58e-04 |
| GO:BP | GO:0090100 | positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 55 | 86 | 3.63e-04 |
| GO:BP | GO:0002376 | immune system process | 652 | 1410 | 3.74e-04 |
| GO:BP | GO:0046631 | alpha-beta T cell activation | 56 | 88 | 3.76e-04 |
| GO:BP | GO:0050673 | epithelial cell proliferation | 159 | 300 | 3.86e-04 |
| GO:BP | GO:0008150 | biological_process | 4682 | 11244 | 3.90e-04 |
| GO:BP | GO:0003177 | pulmonary valve development | 19 | 22 | 3.91e-04 |
| GO:BP | GO:0060390 | regulation of SMAD protein signal transduction | 35 | 49 | 3.94e-04 |
| GO:BP | GO:0042327 | positive regulation of phosphorylation | 212 | 415 | 4.15e-04 |
| GO:BP | GO:0003184 | pulmonary valve morphogenesis | 17 | 19 | 4.23e-04 |
| GO:BP | GO:0030072 | peptide hormone secretion | 93 | 162 | 4.29e-04 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | 387 | 805 | 4.34e-04 |
| GO:BP | GO:0007159 | leukocyte cell-cell adhesion | 120 | 218 | 4.42e-04 |
| GO:BP | GO:0099643 | signal release from synapse | 63 | 102 | 4.47e-04 |
| GO:BP | GO:0007269 | neurotransmitter secretion | 63 | 102 | 4.47e-04 |
| GO:BP | GO:0071692 | protein localization to extracellular region | 138 | 256 | 4.50e-04 |
| GO:BP | GO:0002573 | myeloid leukocyte differentiation | 88 | 152 | 4.53e-04 |
| GO:BP | GO:0014033 | neural crest cell differentiation | 50 | 77 | 4.63e-04 |
| GO:BP | GO:0035108 | limb morphogenesis | 67 | 110 | 4.70e-04 |
| GO:BP | GO:0035107 | appendage morphogenesis | 67 | 110 | 4.70e-04 |
| GO:BP | GO:0060173 | limb development | 80 | 136 | 4.80e-04 |
| GO:BP | GO:0007416 | synapse assembly | 80 | 136 | 4.80e-04 |
| GO:BP | GO:0048736 | appendage development | 80 | 136 | 4.80e-04 |
| GO:BP | GO:0098739 | import across plasma membrane | 73 | 122 | 4.85e-04 |
| GO:BP | GO:0035148 | tube formation | 74 | 124 | 4.85e-04 |
| GO:BP | GO:0055010 | ventricular cardiac muscle tissue morphogenesis | 32 | 44 | 4.85e-04 |
| GO:BP | GO:0007215 | glutamate receptor signaling pathway | 22 | 27 | 4.95e-04 |
| GO:BP | GO:1904064 | positive regulation of cation transmembrane transport | 52 | 81 | 4.99e-04 |
| GO:BP | GO:0099175 | regulation of postsynapse organization | 52 | 81 | 4.99e-04 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | 386 | 804 | 4.99e-04 |
| GO:BP | GO:0006954 | inflammatory response | 216 | 425 | 5.09e-04 |
| GO:BP | GO:0002027 | regulation of heart rate | 53 | 83 | 5.18e-04 |
| GO:BP | GO:0014902 | myotube differentiation | 54 | 85 | 5.38e-04 |
| GO:BP | GO:0042325 | regulation of phosphorylation | 332 | 683 | 5.46e-04 |
| GO:BP | GO:0032101 | regulation of response to external stimulus | 319 | 654 | 5.59e-04 |
| GO:BP | GO:0097120 | receptor localization to synapse | 33 | 46 | 5.63e-04 |
| GO:BP | GO:0072171 | mesonephric tubule morphogenesis | 33 | 46 | 5.63e-04 |
| GO:BP | GO:0042981 | regulation of apoptotic process | 485 | 1031 | 6.21e-04 |
| GO:BP | GO:0043583 | ear development | 87 | 151 | 6.21e-04 |
| GO:BP | GO:0051345 | positive regulation of hydrolase activity | 142 | 266 | 6.27e-04 |
| GO:BP | GO:0003272 | endocardial cushion formation | 20 | 24 | 6.27e-04 |
| GO:BP | GO:0001755 | neural crest cell migration | 34 | 48 | 6.48e-04 |
| GO:BP | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 34 | 48 | 6.48e-04 |
| GO:BP | GO:0046649 | lymphocyte activation | 224 | 444 | 6.54e-04 |
| GO:BP | GO:0140238 | presynaptic endocytosis | 40 | 59 | 6.65e-04 |
| GO:BP | GO:0050920 | regulation of chemotaxis | 78 | 133 | 6.65e-04 |
| GO:BP | GO:0042471 | ear morphogenesis | 48 | 74 | 6.65e-04 |
| GO:BP | GO:0051961 | negative regulation of nervous system development | 66 | 109 | 6.65e-04 |
| GO:BP | GO:0048864 | stem cell development | 48 | 74 | 6.65e-04 |
| GO:BP | GO:0010927 | cellular component assembly involved in morphogenesis | 65 | 107 | 6.65e-04 |
| GO:BP | GO:0007266 | Rho protein signal transduction | 66 | 109 | 6.65e-04 |
| GO:BP | GO:0048839 | inner ear development | 78 | 133 | 6.65e-04 |
| GO:BP | GO:0014888 | striated muscle adaptation | 30 | 41 | 6.87e-04 |
| GO:BP | GO:0040008 | regulation of growth | 232 | 462 | 6.87e-04 |
| GO:BP | GO:0061383 | trabecula morphogenesis | 30 | 41 | 6.87e-04 |
| GO:BP | GO:0098815 | modulation of excitatory postsynaptic potential | 30 | 41 | 6.87e-04 |
| GO:BP | GO:0003002 | regionalization | 138 | 258 | 6.91e-04 |
| GO:BP | GO:0050790 | regulation of catalytic activity | 424 | 893 | 6.91e-04 |
| GO:BP | GO:0043067 | regulation of programmed cell death | 497 | 1060 | 7.18e-04 |
| GO:BP | GO:0090497 | mesenchymal cell migration | 35 | 50 | 7.18e-04 |
| GO:BP | GO:0009991 | response to extracellular stimulus | 193 | 377 | 7.52e-04 |
| GO:BP | GO:0071375 | cellular response to peptide hormone stimulus | 125 | 231 | 7.94e-04 |
| GO:BP | GO:0007498 | mesoderm development | 53 | 84 | 7.97e-04 |
| GO:BP | GO:0048645 | animal organ formation | 36 | 52 | 8.05e-04 |
| GO:BP | GO:0060079 | excitatory postsynaptic potential | 43 | 65 | 8.21e-04 |
| GO:BP | GO:0022407 | regulation of cell-cell adhesion | 147 | 278 | 8.25e-04 |
| GO:BP | GO:0060070 | canonical Wnt signaling pathway | 130 | 242 | 8.75e-04 |
| GO:BP | GO:0072078 | nephron tubule morphogenesis | 37 | 54 | 8.91e-04 |
| GO:BP | GO:0001704 | formation of primary germ layer | 58 | 94 | 8.93e-04 |
| GO:BP | GO:0070372 | regulation of ERK1 and ERK2 cascade | 98 | 175 | 9.11e-04 |
| GO:BP | GO:0110110 | positive regulation of animal organ morphogenesis | 21 | 26 | 9.11e-04 |
| GO:BP | GO:0060043 | regulation of cardiac muscle cell proliferation | 24 | 31 | 9.11e-04 |
| GO:BP | GO:0014032 | neural crest cell development | 45 | 69 | 9.18e-04 |
| GO:BP | GO:0003158 | endothelium development | 61 | 100 | 9.25e-04 |
| GO:BP | GO:0055082 | intracellular chemical homeostasis | 242 | 486 | 9.29e-04 |
| GO:BP | GO:0034764 | positive regulation of transmembrane transport | 76 | 130 | 9.29e-04 |
| GO:BP | GO:0030010 | establishment of cell polarity | 73 | 124 | 9.41e-04 |
| GO:BP | GO:0008360 | regulation of cell shape | 64 | 106 | 9.41e-04 |
| GO:BP | GO:0001838 | embryonic epithelial tube formation | 64 | 106 | 9.41e-04 |
| GO:BP | GO:0031214 | biomineral tissue development | 64 | 106 | 9.41e-04 |
| GO:BP | GO:0007612 | learning | 66 | 110 | 9.48e-04 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | 217 | 431 | 9.52e-04 |
| GO:BP | GO:0003229 | ventricular cardiac muscle tissue development | 38 | 56 | 9.57e-04 |
| GO:BP | GO:0003300 | cardiac muscle hypertrophy | 47 | 73 | 9.98e-04 |
| GO:BP | GO:0018105 | peptidyl-serine phosphorylation | 91 | 161 | 1.03e-03 |
| GO:BP | GO:0061333 | renal tubule morphogenesis | 39 | 58 | 1.04e-03 |
| GO:BP | GO:0048488 | synaptic vesicle endocytosis | 39 | 58 | 1.04e-03 |
| GO:BP | GO:0014896 | muscle hypertrophy | 48 | 75 | 1.04e-03 |
| GO:BP | GO:0008544 | epidermis development | 114 | 209 | 1.04e-03 |
| GO:BP | GO:0002761 | regulation of myeloid leukocyte differentiation | 50 | 79 | 1.11e-03 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | 40 | 60 | 1.12e-03 |
| GO:BP | GO:0006942 | regulation of striated muscle contraction | 51 | 81 | 1.15e-03 |
| GO:BP | GO:0060412 | ventricular septum morphogenesis | 29 | 40 | 1.16e-03 |
| GO:BP | GO:0050708 | regulation of protein secretion | 99 | 178 | 1.16e-03 |
| GO:BP | GO:0061036 | positive regulation of cartilage development | 19 | 23 | 1.16e-03 |
| GO:BP | GO:0006873 | intracellular monoatomic ion homeostasis | 184 | 360 | 1.20e-03 |
| GO:BP | GO:0009306 | protein secretion | 134 | 252 | 1.20e-03 |
| GO:BP | GO:0035592 | establishment of protein localization to extracellular region | 134 | 252 | 1.20e-03 |
| GO:BP | GO:0030097 | hemopoiesis | 303 | 624 | 1.22e-03 |
| GO:BP | GO:0034446 | substrate adhesion-dependent cell spreading | 54 | 87 | 1.22e-03 |
| GO:BP | GO:0030073 | insulin secretion | 79 | 137 | 1.22e-03 |
| GO:BP | GO:0060421 | positive regulation of heart growth | 22 | 28 | 1.22e-03 |
| GO:BP | GO:2000463 | positive regulation of excitatory postsynaptic potential | 22 | 28 | 1.22e-03 |
| GO:BP | GO:0030947 | regulation of vascular endothelial growth factor receptor signaling pathway | 22 | 28 | 1.22e-03 |
| GO:BP | GO:0048732 | gland development | 160 | 308 | 1.22e-03 |
| GO:BP | GO:0050900 | leukocyte migration | 107 | 195 | 1.23e-03 |
| GO:BP | GO:0086003 | cardiac muscle cell contraction | 42 | 64 | 1.25e-03 |
| GO:BP | GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 56 | 91 | 1.25e-03 |
| GO:BP | GO:0019935 | cyclic-nucleotide-mediated signaling | 35 | 51 | 1.26e-03 |
| GO:BP | GO:0050771 | negative regulation of axonogenesis | 35 | 51 | 1.26e-03 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | 146 | 278 | 1.26e-03 |
| GO:BP | GO:0010976 | positive regulation of neuron projection development | 75 | 129 | 1.26e-03 |
| GO:BP | GO:0001707 | mesoderm formation | 35 | 51 | 1.26e-03 |
| GO:BP | GO:0048675 | axon extension | 58 | 95 | 1.27e-03 |
| GO:BP | GO:0031667 | response to nutrient levels | 181 | 354 | 1.30e-03 |
| GO:BP | GO:0035296 | regulation of tube diameter | 61 | 101 | 1.30e-03 |
| GO:BP | GO:0097746 | blood vessel diameter maintenance | 61 | 101 | 1.30e-03 |
| GO:BP | GO:0035150 | regulation of tube size | 61 | 101 | 1.30e-03 |
| GO:BP | GO:0048659 | smooth muscle cell proliferation | 61 | 101 | 1.30e-03 |
| GO:BP | GO:1902107 | positive regulation of leukocyte differentiation | 68 | 115 | 1.30e-03 |
| GO:BP | GO:0050768 | negative regulation of neurogenesis | 62 | 103 | 1.30e-03 |
| GO:BP | GO:1903708 | positive regulation of hemopoiesis | 68 | 115 | 1.30e-03 |
| GO:BP | GO:0032535 | regulation of cellular component size | 150 | 287 | 1.35e-03 |
| GO:BP | GO:0055002 | striated muscle cell development | 44 | 68 | 1.35e-03 |
| GO:BP | GO:0048332 | mesoderm morphogenesis | 36 | 53 | 1.36e-03 |
| GO:BP | GO:0007162 | negative regulation of cell adhesion | 102 | 185 | 1.36e-03 |
| GO:BP | GO:0051896 | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 100 | 181 | 1.43e-03 |
| GO:BP | GO:0030031 | cell projection assembly | 223 | 447 | 1.45e-03 |
| GO:BP | GO:0071559 | response to transforming growth factor beta | 118 | 219 | 1.47e-03 |
| GO:BP | GO:0002064 | epithelial cell development | 84 | 148 | 1.51e-03 |
| GO:BP | GO:0014897 | striated muscle hypertrophy | 47 | 74 | 1.52e-03 |
| GO:BP | GO:0061326 | renal tubule development | 47 | 74 | 1.52e-03 |
| GO:BP | GO:0030003 | intracellular monoatomic cation homeostasis | 181 | 355 | 1.54e-03 |
| GO:BP | GO:0010817 | regulation of hormone levels | 164 | 318 | 1.54e-03 |
| GO:BP | GO:0031099 | regeneration | 82 | 144 | 1.55e-03 |
| GO:BP | GO:0030513 | positive regulation of BMP signaling pathway | 23 | 30 | 1.55e-03 |
| GO:BP | GO:0060996 | dendritic spine development | 48 | 76 | 1.56e-03 |
| GO:BP | GO:0046777 | protein autophosphorylation | 81 | 142 | 1.57e-03 |
| GO:BP | GO:0070371 | ERK1 and ERK2 cascade | 106 | 194 | 1.58e-03 |
| GO:BP | GO:0043217 | myelin maintenance | 13 | 14 | 1.59e-03 |
| GO:BP | GO:0010954 | positive regulation of protein processing | 15 | 17 | 1.59e-03 |
| GO:BP | GO:0060977 | coronary vasculature morphogenesis | 15 | 17 | 1.59e-03 |
| GO:BP | GO:0055023 | positive regulation of cardiac muscle tissue growth | 20 | 25 | 1.60e-03 |
| GO:BP | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 79 | 138 | 1.60e-03 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | 168 | 327 | 1.62e-03 |
| GO:BP | GO:0002791 | regulation of peptide secretion | 76 | 132 | 1.67e-03 |
| GO:BP | GO:0014855 | striated muscle cell proliferation | 39 | 59 | 1.67e-03 |
| GO:BP | GO:0072009 | nephron epithelium development | 52 | 84 | 1.70e-03 |
| GO:BP | GO:0061387 | regulation of extent of cell growth | 54 | 88 | 1.76e-03 |
| GO:BP | GO:0061614 | miRNA transcription | 40 | 61 | 1.78e-03 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | 216 | 433 | 1.81e-03 |
| GO:BP | GO:0140115 | export across plasma membrane | 33 | 48 | 1.81e-03 |
| GO:BP | GO:0010721 | negative regulation of cell development | 100 | 182 | 1.83e-03 |
| GO:BP | GO:0031503 | protein-containing complex localization | 88 | 157 | 1.83e-03 |
| GO:BP | GO:0007043 | cell-cell junction assembly | 63 | 106 | 1.83e-03 |
| GO:BP | GO:0038127 | ERBB signaling pathway | 62 | 104 | 1.83e-03 |
| GO:BP | GO:0001658 | branching involved in ureteric bud morphogenesis | 28 | 39 | 1.85e-03 |
| GO:BP | GO:0050922 | negative regulation of chemotaxis | 28 | 39 | 1.85e-03 |
| GO:BP | GO:0097061 | dendritic spine organization | 41 | 63 | 1.85e-03 |
| GO:BP | GO:0007492 | endoderm development | 41 | 63 | 1.85e-03 |
| GO:BP | GO:0070482 | response to oxygen levels | 139 | 265 | 1.85e-03 |
| GO:BP | GO:1902284 | neuron projection extension involved in neuron projection guidance | 24 | 32 | 1.90e-03 |
| GO:BP | GO:0048846 | axon extension involved in axon guidance | 24 | 32 | 1.90e-03 |
| GO:BP | GO:0008361 | regulation of cell size | 83 | 147 | 2.00e-03 |
| GO:BP | GO:0003148 | outflow tract septum morphogenesis | 18 | 22 | 2.09e-03 |
| GO:BP | GO:0060045 | positive regulation of cardiac muscle cell proliferation | 18 | 22 | 2.09e-03 |
| GO:BP | GO:1903779 | regulation of cardiac conduction | 18 | 22 | 2.09e-03 |
| GO:BP | GO:1905330 | regulation of morphogenesis of an epithelium | 29 | 41 | 2.12e-03 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | 206 | 412 | 2.14e-03 |
| GO:BP | GO:0106027 | neuron projection organization | 45 | 71 | 2.17e-03 |
| GO:BP | GO:0030178 | negative regulation of Wnt signaling pathway | 77 | 135 | 2.22e-03 |
| GO:BP | GO:0046883 | regulation of hormone secretion | 91 | 164 | 2.24e-03 |
| GO:BP | GO:0014910 | regulation of smooth muscle cell migration | 36 | 54 | 2.29e-03 |
| GO:BP | GO:0060541 | respiratory system development | 90 | 162 | 2.29e-03 |
| GO:BP | GO:0071868 | cellular response to monoamine stimulus | 25 | 34 | 2.29e-03 |
| GO:BP | GO:0071870 | cellular response to catecholamine stimulus | 25 | 34 | 2.29e-03 |
| GO:BP | GO:0001764 | neuron migration | 74 | 129 | 2.30e-03 |
| GO:BP | GO:0120031 | plasma membrane bounded cell projection assembly | 217 | 437 | 2.37e-03 |
| GO:BP | GO:0072175 | epithelial tube formation | 68 | 117 | 2.48e-03 |
| GO:BP | GO:0071560 | cellular response to transforming growth factor beta stimulus | 115 | 215 | 2.49e-03 |
| GO:BP | GO:0048640 | negative regulation of developmental growth | 52 | 85 | 2.50e-03 |
| GO:BP | GO:0032231 | regulation of actin filament bundle assembly | 52 | 85 | 2.50e-03 |
| GO:BP | GO:0045446 | endothelial cell differentiation | 52 | 85 | 2.50e-03 |
| GO:BP | GO:0050865 | regulation of cell activation | 176 | 347 | 2.52e-03 |
| GO:BP | GO:0014020 | primary neural tube formation | 53 | 87 | 2.52e-03 |
| GO:BP | GO:0043500 | muscle adaptation | 54 | 89 | 2.54e-03 |
| GO:BP | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 64 | 109 | 2.54e-03 |
| GO:BP | GO:0007009 | plasma membrane organization | 63 | 107 | 2.55e-03 |
| GO:BP | GO:0008217 | regulation of blood pressure | 62 | 105 | 2.56e-03 |
| GO:BP | GO:0002028 | regulation of sodium ion transport | 38 | 58 | 2.56e-03 |
| GO:BP | GO:0007265 | Ras protein signal transduction | 57 | 95 | 2.56e-03 |
| GO:BP | GO:1902105 | regulation of leukocyte differentiation | 105 | 194 | 2.58e-03 |
| GO:BP | GO:0007520 | myoblast fusion | 22 | 29 | 2.65e-03 |
| GO:BP | GO:0150117 | positive regulation of cell-substrate junction organization | 22 | 29 | 2.65e-03 |
| GO:BP | GO:0003203 | endocardial cushion morphogenesis | 26 | 36 | 2.65e-03 |
| GO:BP | GO:0010463 | mesenchymal cell proliferation | 26 | 36 | 2.65e-03 |
| GO:BP | GO:0051703 | biological process involved in intraspecies interaction between organisms | 22 | 29 | 2.65e-03 |
| GO:BP | GO:0061384 | heart trabecula morphogenesis | 22 | 29 | 2.65e-03 |
| GO:BP | GO:0035176 | social behavior | 22 | 29 | 2.65e-03 |
| GO:BP | GO:0071867 | response to monoamine | 26 | 36 | 2.65e-03 |
| GO:BP | GO:0071869 | response to catecholamine | 26 | 36 | 2.65e-03 |
| GO:BP | GO:0035418 | protein localization to synapse | 39 | 60 | 2.65e-03 |
| GO:BP | GO:0014909 | smooth muscle cell migration | 39 | 60 | 2.65e-03 |
| GO:BP | GO:0018209 | peptidyl-serine modification | 93 | 169 | 2.71e-03 |
| GO:BP | GO:0032878 | regulation of establishment or maintenance of cell polarity | 19 | 24 | 2.85e-03 |
| GO:BP | GO:0003299 | muscle hypertrophy in response to stress | 19 | 24 | 2.85e-03 |
| GO:BP | GO:0014898 | cardiac muscle hypertrophy in response to stress | 19 | 24 | 2.85e-03 |
| GO:BP | GO:0014887 | cardiac muscle adaptation | 19 | 24 | 2.85e-03 |
| GO:BP | GO:0021700 | developmental maturation | 109 | 203 | 2.88e-03 |
| GO:BP | GO:0050772 | positive regulation of axonogenesis | 41 | 64 | 2.89e-03 |
| GO:BP | GO:0010594 | regulation of endothelial cell migration | 77 | 136 | 2.89e-03 |
| GO:BP | GO:0090087 | regulation of peptide transport | 76 | 134 | 2.94e-03 |
| GO:BP | GO:0030239 | myofibril assembly | 42 | 66 | 2.99e-03 |
| GO:BP | GO:0030111 | regulation of Wnt signaling pathway | 136 | 261 | 2.99e-03 |
| GO:BP | GO:0051641 | cellular localization | 1157 | 2623 | 3.01e-03 |
| GO:BP | GO:0090276 | regulation of peptide hormone secretion | 74 | 130 | 3.04e-03 |
| GO:BP | GO:0060420 | regulation of heart growth | 33 | 49 | 3.05e-03 |
| GO:BP | GO:0070168 | negative regulation of biomineral tissue development | 14 | 16 | 3.05e-03 |
| GO:BP | GO:0072080 | nephron tubule development | 44 | 70 | 3.17e-03 |
| GO:BP | GO:0014812 | muscle cell migration | 45 | 72 | 3.25e-03 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | 45 | 72 | 3.25e-03 |
| GO:BP | GO:0002274 | myeloid leukocyte activation | 68 | 118 | 3.31e-03 |
| GO:BP | GO:0051963 | regulation of synapse assembly | 47 | 76 | 3.38e-03 |
| GO:BP | GO:0050773 | regulation of dendrite development | 48 | 78 | 3.44e-03 |
| GO:BP | GO:0050817 | coagulation | 82 | 147 | 3.47e-03 |
| GO:BP | GO:0001508 | action potential | 60 | 102 | 3.57e-03 |
| GO:BP | GO:0007173 | epidermal growth factor receptor signaling pathway | 52 | 86 | 3.58e-03 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | 307 | 642 | 3.58e-03 |
| GO:BP | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 55 | 92 | 3.60e-03 |
| GO:BP | GO:0001841 | neural tube formation | 55 | 92 | 3.60e-03 |
| GO:BP | GO:0030098 | lymphocyte differentiation | 130 | 249 | 3.60e-03 |
| GO:BP | GO:0010657 | muscle cell apoptotic process | 36 | 55 | 3.69e-03 |
| GO:BP | GO:1902656 | calcium ion import into cytosol | 20 | 26 | 3.70e-03 |
| GO:BP | GO:1901653 | cellular response to peptide | 141 | 273 | 3.75e-03 |
| GO:BP | GO:0032924 | activin receptor signaling pathway | 24 | 33 | 3.82e-03 |
| GO:BP | GO:0019725 | cellular homeostasis | 272 | 564 | 4.09e-03 |
| GO:BP | GO:0086002 | cardiac muscle cell action potential involved in contraction | 30 | 44 | 4.16e-03 |
| GO:BP | GO:0034103 | regulation of tissue remodeling | 30 | 44 | 4.16e-03 |
| GO:BP | GO:0055021 | regulation of cardiac muscle tissue growth | 30 | 44 | 4.16e-03 |
| GO:BP | GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels | 39 | 61 | 4.23e-03 |
| GO:BP | GO:0022409 | positive regulation of cell-cell adhesion | 95 | 175 | 4.23e-03 |
| GO:BP | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 71 | 125 | 4.28e-03 |
| GO:BP | GO:0008284 | positive regulation of cell population proliferation | 290 | 605 | 4.28e-03 |
| GO:BP | GO:0002694 | regulation of leukocyte activation | 159 | 313 | 4.33e-03 |
| GO:BP | GO:0019933 | cAMP-mediated signaling | 25 | 35 | 4.41e-03 |
| GO:BP | GO:0009952 | anterior/posterior pattern specification | 69 | 121 | 4.41e-03 |
| GO:BP | GO:0046622 | positive regulation of organ growth | 25 | 35 | 4.41e-03 |
| GO:BP | GO:2000116 | regulation of cysteine-type endopeptidase activity | 69 | 121 | 4.41e-03 |
| GO:BP | GO:0051651 | maintenance of location in cell | 93 | 171 | 4.44e-03 |
| GO:BP | GO:0061351 | neural precursor cell proliferation | 68 | 119 | 4.46e-03 |
| GO:BP | GO:1990778 | protein localization to cell periphery | 147 | 287 | 4.46e-03 |
| GO:BP | GO:0030316 | osteoclast differentiation | 41 | 65 | 4.46e-03 |
| GO:BP | GO:0003197 | endocardial cushion development | 31 | 46 | 4.47e-03 |
| GO:BP | GO:0048705 | skeletal system morphogenesis | 82 | 148 | 4.48e-03 |
| GO:BP | GO:0030323 | respiratory tube development | 82 | 148 | 4.48e-03 |
| GO:BP | GO:0007599 | hemostasis | 82 | 148 | 4.48e-03 |
| GO:BP | GO:0036465 | synaptic vesicle recycling | 42 | 67 | 4.55e-03 |
| GO:BP | GO:0051588 | regulation of neurotransmitter transport | 42 | 67 | 4.55e-03 |
| GO:BP | GO:0003171 | atrioventricular valve development | 21 | 28 | 4.55e-03 |
| GO:BP | GO:0048841 | regulation of axon extension involved in axon guidance | 21 | 28 | 4.55e-03 |
| GO:BP | GO:0050796 | regulation of insulin secretion | 65 | 113 | 4.61e-03 |
| GO:BP | GO:0043547 | positive regulation of GTPase activity | 65 | 113 | 4.61e-03 |
| GO:BP | GO:0018107 | peptidyl-threonine phosphorylation | 43 | 69 | 4.64e-03 |
| GO:BP | GO:0007596 | blood coagulation | 80 | 144 | 4.66e-03 |
| GO:BP | GO:0030324 | lung development | 80 | 144 | 4.66e-03 |
| GO:BP | GO:0031102 | neuron projection regeneration | 32 | 48 | 4.75e-03 |
| GO:BP | GO:0048592 | eye morphogenesis | 62 | 107 | 4.77e-03 |
| GO:BP | GO:0097581 | lamellipodium organization | 45 | 73 | 4.79e-03 |
| GO:BP | GO:0042110 | T cell activation | 155 | 305 | 4.84e-03 |
| GO:BP | GO:1903319 | positive regulation of protein maturation | 15 | 18 | 4.86e-03 |
| GO:BP | GO:0042063 | gliogenesis | 126 | 242 | 4.89e-03 |
| GO:BP | GO:0030517 | negative regulation of axon extension | 26 | 37 | 4.89e-03 |
| GO:BP | GO:0010658 | striated muscle cell apoptotic process | 26 | 37 | 4.89e-03 |
| GO:BP | GO:0010660 | regulation of muscle cell apoptotic process | 33 | 50 | 4.97e-03 |
| GO:BP | GO:0030326 | embryonic limb morphogenesis | 52 | 87 | 4.97e-03 |
| GO:BP | GO:1901019 | regulation of calcium ion transmembrane transporter activity | 33 | 50 | 4.97e-03 |
| GO:BP | GO:0048814 | regulation of dendrite morphogenesis | 33 | 50 | 4.97e-03 |
| GO:BP | GO:0031623 | receptor internalization | 53 | 89 | 4.97e-03 |
| GO:BP | GO:0030038 | contractile actin filament bundle assembly | 54 | 91 | 4.97e-03 |
| GO:BP | GO:0110053 | regulation of actin filament organization | 112 | 212 | 4.97e-03 |
| GO:BP | GO:0033135 | regulation of peptidyl-serine phosphorylation | 51 | 85 | 4.97e-03 |
| GO:BP | GO:0043149 | stress fiber assembly | 54 | 91 | 4.97e-03 |
| GO:BP | GO:0035113 | embryonic appendage morphogenesis | 52 | 87 | 4.97e-03 |
| GO:BP | GO:0010765 | positive regulation of sodium ion transport | 18 | 23 | 4.99e-03 |
| GO:BP | GO:0048668 | collateral sprouting | 18 | 23 | 4.99e-03 |
| GO:BP | GO:0035051 | cardiocyte differentiation | 74 | 132 | 5.22e-03 |
| GO:BP | GO:0032906 | transforming growth factor beta2 production | 9 | 9 | 5.23e-03 |
| GO:BP | GO:0032909 | regulation of transforming growth factor beta2 production | 9 | 9 | 5.23e-03 |
| GO:BP | GO:1900024 | regulation of substrate adhesion-dependent cell spreading | 34 | 52 | 5.24e-03 |
| GO:BP | GO:1904427 | positive regulation of calcium ion transmembrane transport | 34 | 52 | 5.24e-03 |
| GO:BP | GO:0050678 | regulation of epithelial cell proliferation | 129 | 249 | 5.34e-03 |
| GO:BP | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 35 | 54 | 5.50e-03 |
| GO:BP | GO:0086065 | cell communication involved in cardiac conduction | 35 | 54 | 5.50e-03 |
| GO:BP | GO:0001666 | response to hypoxia | 121 | 232 | 5.67e-03 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | 295 | 619 | 5.73e-03 |
| GO:BP | GO:0046928 | regulation of neurotransmitter secretion | 36 | 56 | 5.75e-03 |
| GO:BP | GO:0051251 | positive regulation of lymphocyte activation | 99 | 185 | 5.84e-03 |
| GO:BP | GO:0010812 | negative regulation of cell-substrate adhesion | 28 | 41 | 5.92e-03 |
| GO:BP | GO:0008543 | fibroblast growth factor receptor signaling pathway | 37 | 58 | 5.96e-03 |
| GO:BP | GO:0032414 | positive regulation of ion transmembrane transporter activity | 37 | 58 | 5.96e-03 |
| GO:BP | GO:0001935 | endothelial cell proliferation | 65 | 114 | 6.14e-03 |
| GO:BP | GO:0010001 | glial cell differentiation | 97 | 181 | 6.19e-03 |
| GO:BP | GO:0098703 | calcium ion import across plasma membrane | 19 | 25 | 6.39e-03 |
| GO:BP | GO:0072578 | neurotransmitter-gated ion channel clustering | 11 | 12 | 6.42e-03 |
| GO:BP | GO:0003222 | ventricular trabecula myocardium morphogenesis | 11 | 12 | 6.42e-03 |
| GO:BP | GO:0009880 | embryonic pattern specification | 29 | 43 | 6.42e-03 |
| GO:BP | GO:0032332 | positive regulation of chondrocyte differentiation | 11 | 12 | 6.42e-03 |
| GO:BP | GO:0001701 | in utero embryonic development | 166 | 331 | 6.51e-03 |
| GO:BP | GO:0001570 | vasculogenesis | 41 | 66 | 6.61e-03 |
| GO:BP | GO:0002040 | sprouting angiogenesis | 57 | 98 | 6.81e-03 |
| GO:BP | GO:0046620 | regulation of organ growth | 43 | 70 | 6.82e-03 |
| GO:BP | GO:0016079 | synaptic vesicle exocytosis | 43 | 70 | 6.82e-03 |
| GO:BP | GO:0055123 | digestive system development | 56 | 96 | 6.85e-03 |
| GO:BP | GO:0060997 | dendritic spine morphogenesis | 30 | 45 | 6.87e-03 |
| GO:BP | GO:0030516 | regulation of axon extension | 45 | 74 | 6.96e-03 |
| GO:BP | GO:0048565 | digestive tract development | 52 | 88 | 7.03e-03 |
| GO:BP | GO:0050867 | positive regulation of cell activation | 107 | 203 | 7.03e-03 |
| GO:BP | GO:0010659 | cardiac muscle cell apoptotic process | 24 | 34 | 7.03e-03 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | 560 | 1231 | 7.03e-03 |
| GO:BP | GO:0010662 | regulation of striated muscle cell apoptotic process | 24 | 34 | 7.03e-03 |
| GO:BP | GO:0060828 | regulation of canonical Wnt signaling pathway | 107 | 203 | 7.03e-03 |
| GO:BP | GO:0060606 | tube closure | 50 | 84 | 7.03e-03 |
| GO:BP | GO:0002065 | columnar/cuboidal epithelial cell differentiation | 49 | 82 | 7.03e-03 |
| GO:BP | GO:0043114 | regulation of vascular permeability | 24 | 34 | 7.03e-03 |
| GO:BP | GO:0140747 | regulation of ncRNA transcription | 48 | 80 | 7.03e-03 |
| GO:BP | GO:0032330 | regulation of chondrocyte differentiation | 24 | 34 | 7.03e-03 |
| GO:BP | GO:0003230 | cardiac atrium development | 24 | 34 | 7.03e-03 |
| GO:BP | GO:0071496 | cellular response to external stimulus | 137 | 268 | 7.13e-03 |
| GO:BP | GO:0051249 | regulation of lymphocyte activation | 142 | 279 | 7.24e-03 |
| GO:BP | GO:0045860 | positive regulation of protein kinase activity | 98 | 184 | 7.44e-03 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | 561 | 1234 | 7.44e-03 |
| GO:BP | GO:1903053 | regulation of extracellular matrix organization | 32 | 49 | 7.64e-03 |
| GO:BP | GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 20 | 27 | 7.65e-03 |
| GO:BP | GO:0070570 | regulation of neuron projection regeneration | 20 | 27 | 7.65e-03 |
| GO:BP | GO:0031279 | regulation of cyclase activity | 20 | 27 | 7.65e-03 |
| GO:BP | GO:0002696 | positive regulation of leukocyte activation | 104 | 197 | 7.69e-03 |
| GO:BP | GO:1903037 | regulation of leukocyte cell-cell adhesion | 104 | 197 | 7.69e-03 |
| GO:BP | GO:0038084 | vascular endothelial growth factor signaling pathway | 25 | 36 | 7.83e-03 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | 612 | 1354 | 8.15e-03 |
| GO:BP | GO:0043367 | CD4-positive, alpha-beta T cell differentiation | 34 | 53 | 8.32e-03 |
| GO:BP | GO:0060491 | regulation of cell projection assembly | 86 | 159 | 8.32e-03 |
| GO:BP | GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 85 | 157 | 8.56e-03 |
| GO:BP | GO:0003073 | regulation of systemic arterial blood pressure | 35 | 55 | 8.63e-03 |
| GO:BP | GO:0036293 | response to decreased oxygen levels | 125 | 243 | 8.83e-03 |
| GO:BP | GO:0055007 | cardiac muscle cell differentiation | 60 | 105 | 8.84e-03 |
| GO:BP | GO:0021954 | central nervous system neuron development | 36 | 57 | 8.88e-03 |
| GO:BP | GO:0051899 | membrane depolarization | 36 | 57 | 8.88e-03 |
| GO:BP | GO:0140239 | postsynaptic endocytosis | 14 | 17 | 8.95e-03 |
| GO:BP | GO:0048169 | regulation of long-term neuronal synaptic plasticity | 14 | 17 | 8.95e-03 |
| GO:BP | GO:0002433 | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | 14 | 17 | 8.95e-03 |
| GO:BP | GO:0098884 | postsynaptic neurotransmitter receptor internalization | 14 | 17 | 8.95e-03 |
| GO:BP | GO:0051590 | positive regulation of neurotransmitter transport | 14 | 17 | 8.95e-03 |
| GO:BP | GO:0060445 | branching involved in salivary gland morphogenesis | 14 | 17 | 8.95e-03 |
| GO:BP | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 14 | 17 | 8.95e-03 |
| GO:BP | GO:0097106 | postsynaptic density organization | 21 | 29 | 8.96e-03 |
| GO:BP | GO:0062013 | positive regulation of small molecule metabolic process | 57 | 99 | 9.15e-03 |
| GO:BP | GO:0035249 | synaptic transmission, glutamatergic | 38 | 61 | 9.23e-03 |
| GO:BP | GO:0072091 | regulation of stem cell proliferation | 38 | 61 | 9.23e-03 |
| GO:BP | GO:0035567 | non-canonical Wnt signaling pathway | 38 | 61 | 9.23e-03 |
| GO:BP | GO:0006950 | response to stress | 1114 | 2540 | 9.26e-03 |
| GO:BP | GO:0050795 | regulation of behavior | 27 | 40 | 9.26e-03 |
| GO:BP | GO:0032411 | positive regulation of transporter activity | 39 | 63 | 9.37e-03 |
| GO:BP | GO:0086001 | cardiac muscle cell action potential | 39 | 63 | 9.37e-03 |
| GO:BP | GO:0055117 | regulation of cardiac muscle contraction | 40 | 65 | 9.52e-03 |
| GO:BP | GO:0006887 | exocytosis | 122 | 237 | 9.60e-03 |
| GO:BP | GO:0010595 | positive regulation of endothelial cell migration | 52 | 89 | 9.60e-03 |
| GO:BP | GO:0001892 | embryonic placenta development | 41 | 67 | 9.61e-03 |
| GO:BP | GO:0030534 | adult behavior | 51 | 87 | 9.64e-03 |
| GO:BP | GO:0048593 | camera-type eye morphogenesis | 51 | 87 | 9.64e-03 |
| GO:BP | GO:0110020 | regulation of actomyosin structure organization | 51 | 87 | 9.64e-03 |
| GO:BP | GO:0001843 | neural tube closure | 49 | 83 | 9.76e-03 |
| GO:BP | GO:0003014 | renal system process | 44 | 73 | 9.79e-03 |
| GO:BP | GO:0051492 | regulation of stress fiber assembly | 46 | 77 | 9.80e-03 |
| GO:BP | GO:0044344 | cellular response to fibroblast growth factor stimulus | 47 | 79 | 9.80e-03 |
| GO:BP | GO:0001954 | positive regulation of cell-matrix adhesion | 28 | 42 | 9.84e-03 |
| GO:BP | GO:0019229 | regulation of vasoconstriction | 28 | 42 | 9.84e-03 |
| GO:BP | GO:0043434 | response to peptide hormone | 157 | 314 | 1.00e-02 |
| GO:BP | GO:0010644 | cell communication by electrical coupling | 22 | 31 | 1.01e-02 |
| GO:BP | GO:0010665 | regulation of cardiac muscle cell apoptotic process | 22 | 31 | 1.01e-02 |
| GO:BP | GO:0030307 | positive regulation of cell growth | 67 | 120 | 1.01e-02 |
| GO:BP | GO:1903351 | cellular response to dopamine | 22 | 31 | 1.01e-02 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | 29 | 44 | 1.04e-02 |
| GO:BP | GO:0034332 | adherens junction organization | 29 | 44 | 1.04e-02 |
| GO:BP | GO:0045859 | regulation of protein kinase activity | 165 | 332 | 1.05e-02 |
| GO:BP | GO:0051894 | positive regulation of focal adhesion assembly | 18 | 24 | 1.08e-02 |
| GO:BP | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 18 | 24 | 1.08e-02 |
| GO:BP | GO:0045124 | regulation of bone resorption | 18 | 24 | 1.08e-02 |
| GO:BP | GO:0060350 | endochondral bone morphogenesis | 30 | 46 | 1.10e-02 |
| GO:BP | GO:0001890 | placenta development | 62 | 110 | 1.11e-02 |
| GO:BP | GO:0097529 | myeloid leukocyte migration | 62 | 110 | 1.11e-02 |
| GO:BP | GO:0098969 | neurotransmitter receptor transport to postsynaptic membrane | 12 | 14 | 1.11e-02 |
| GO:BP | GO:0003190 | atrioventricular valve formation | 8 | 8 | 1.11e-02 |
| GO:BP | GO:0032634 | interleukin-5 production | 8 | 8 | 1.11e-02 |
| GO:BP | GO:1903540 | establishment of protein localization to postsynaptic membrane | 12 | 14 | 1.11e-02 |
| GO:BP | GO:0060896 | neural plate pattern specification | 8 | 8 | 1.11e-02 |
| GO:BP | GO:0060982 | coronary artery morphogenesis | 8 | 8 | 1.11e-02 |
| GO:BP | GO:0003418 | growth plate cartilage chondrocyte differentiation | 8 | 8 | 1.11e-02 |
| GO:BP | GO:0032674 | regulation of interleukin-5 production | 8 | 8 | 1.11e-02 |
| GO:BP | GO:0051051 | negative regulation of transport | 144 | 286 | 1.11e-02 |
| GO:BP | GO:0072659 | protein localization to plasma membrane | 122 | 238 | 1.13e-02 |
| GO:BP | GO:0009410 | response to xenobiotic stimulus | 138 | 273 | 1.14e-02 |
| GO:BP | GO:0060326 | cell chemotaxis | 82 | 152 | 1.14e-02 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | 152 | 304 | 1.17e-02 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | 32 | 50 | 1.18e-02 |
| GO:BP | GO:1990806 | ligand-gated ion channel signaling pathway | 15 | 19 | 1.20e-02 |
| GO:BP | GO:0099637 | neurotransmitter receptor transport | 15 | 19 | 1.20e-02 |
| GO:BP | GO:0099590 | neurotransmitter receptor internalization | 15 | 19 | 1.20e-02 |
| GO:BP | GO:0098810 | neurotransmitter reuptake | 15 | 19 | 1.20e-02 |
| GO:BP | GO:0009725 | response to hormone | 288 | 610 | 1.21e-02 |
| GO:BP | GO:0001708 | cell fate specification | 33 | 52 | 1.22e-02 |
| GO:BP | GO:0008038 | neuron recognition | 24 | 35 | 1.23e-02 |
| GO:BP | GO:0007605 | sensory perception of sound | 55 | 96 | 1.25e-02 |
| GO:BP | GO:0060143 | positive regulation of syncytium formation by plasma membrane fusion | 10 | 11 | 1.27e-02 |
| GO:BP | GO:0051923 | sulfation | 10 | 11 | 1.27e-02 |
| GO:BP | GO:0021670 | lateral ventricle development | 10 | 11 | 1.27e-02 |
| GO:BP | GO:0045055 | regulated exocytosis | 78 | 144 | 1.27e-02 |
| GO:BP | GO:0003209 | cardiac atrium morphogenesis | 19 | 26 | 1.27e-02 |
| GO:BP | GO:0003181 | atrioventricular valve morphogenesis | 19 | 26 | 1.27e-02 |
| GO:BP | GO:1903055 | positive regulation of extracellular matrix organization | 19 | 26 | 1.27e-02 |
| GO:BP | GO:0032941 | secretion by tissue | 19 | 26 | 1.27e-02 |
| GO:BP | GO:0051047 | positive regulation of secretion | 106 | 204 | 1.29e-02 |
| GO:BP | GO:0010469 | regulation of signaling receptor activity | 36 | 58 | 1.30e-02 |
| GO:BP | GO:0043542 | endothelial cell migration | 92 | 174 | 1.33e-02 |
| GO:BP | GO:0008366 | axon ensheathment | 66 | 119 | 1.33e-02 |
| GO:BP | GO:0007272 | ensheathment of neurons | 66 | 119 | 1.33e-02 |
| GO:BP | GO:1902305 | regulation of sodium ion transmembrane transport | 25 | 37 | 1.33e-02 |
| GO:BP | GO:0098661 | inorganic anion transmembrane transport | 38 | 62 | 1.34e-02 |
| GO:BP | GO:0070167 | regulation of biomineral tissue development | 38 | 62 | 1.34e-02 |
| GO:BP | GO:0071774 | response to fibroblast growth factor | 48 | 82 | 1.34e-02 |
| GO:BP | GO:0150104 | transport across blood-brain barrier | 41 | 68 | 1.36e-02 |
| GO:BP | GO:0071887 | leukocyte apoptotic process | 45 | 76 | 1.36e-02 |
| GO:BP | GO:0018210 | peptidyl-threonine modification | 45 | 76 | 1.36e-02 |
| GO:BP | GO:0097191 | extrinsic apoptotic signaling pathway | 91 | 172 | 1.36e-02 |
| GO:BP | GO:0010232 | vascular transport | 41 | 68 | 1.36e-02 |
| GO:BP | GO:0042552 | myelination | 65 | 117 | 1.36e-02 |
| GO:BP | GO:0035710 | CD4-positive, alpha-beta T cell activation | 40 | 66 | 1.36e-02 |
| GO:BP | GO:0097306 | cellular response to alcohol | 44 | 74 | 1.36e-02 |
| GO:BP | GO:0046578 | regulation of Ras protein signal transduction | 26 | 39 | 1.42e-02 |
| GO:BP | GO:0051965 | positive regulation of synapse assembly | 26 | 39 | 1.42e-02 |
| GO:BP | GO:0052548 | regulation of endopeptidase activity | 82 | 153 | 1.42e-02 |
| GO:BP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 62 | 111 | 1.44e-02 |
| GO:BP | GO:0048713 | regulation of oligodendrocyte differentiation | 20 | 28 | 1.45e-02 |
| GO:BP | GO:0030705 | cytoskeleton-dependent intracellular transport | 94 | 179 | 1.54e-02 |
| GO:BP | GO:0060041 | retina development in camera-type eye | 59 | 105 | 1.54e-02 |
| GO:BP | GO:0032814 | regulation of natural killer cell activation | 13 | 16 | 1.63e-02 |
| GO:BP | GO:0021846 | cell proliferation in forebrain | 13 | 16 | 1.63e-02 |
| GO:BP | GO:0030041 | actin filament polymerization | 68 | 124 | 1.64e-02 |
| GO:BP | GO:0021953 | central nervous system neuron differentiation | 56 | 99 | 1.64e-02 |
| GO:BP | GO:0007616 | long-term memory | 21 | 30 | 1.64e-02 |
| GO:BP | GO:0046850 | regulation of bone remodeling | 21 | 30 | 1.64e-02 |
| GO:BP | GO:0001937 | negative regulation of endothelial cell proliferation | 21 | 30 | 1.64e-02 |
| GO:BP | GO:0048512 | circadian behavior | 21 | 30 | 1.64e-02 |
| GO:BP | GO:0060914 | heart formation | 21 | 30 | 1.64e-02 |
| GO:BP | GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 55 | 97 | 1.66e-02 |
| GO:BP | GO:0010038 | response to metal ion | 126 | 249 | 1.67e-02 |
| GO:BP | GO:0045926 | negative regulation of growth | 96 | 184 | 1.77e-02 |
| GO:BP | GO:0045685 | regulation of glial cell differentiation | 31 | 49 | 1.77e-02 |
| GO:BP | GO:0060711 | labyrinthine layer development | 22 | 32 | 1.81e-02 |
| GO:BP | GO:0062237 | protein localization to postsynapse | 22 | 32 | 1.81e-02 |
| GO:BP | GO:1903539 | protein localization to postsynaptic membrane | 22 | 32 | 1.81e-02 |
| GO:BP | GO:0010656 | negative regulation of muscle cell apoptotic process | 22 | 32 | 1.81e-02 |
| GO:BP | GO:1903350 | response to dopamine | 22 | 32 | 1.81e-02 |
| GO:BP | GO:0007622 | rhythmic behavior | 22 | 32 | 1.81e-02 |
| GO:BP | GO:0030168 | platelet activation | 50 | 87 | 1.81e-02 |
| GO:BP | GO:0010586 | miRNA metabolic process | 50 | 87 | 1.81e-02 |
| GO:BP | GO:0010876 | lipid localization | 148 | 298 | 1.81e-02 |
| GO:BP | GO:0010664 | negative regulation of striated muscle cell apoptotic process | 17 | 23 | 1.83e-02 |
| GO:BP | GO:0048843 | negative regulation of axon extension involved in axon guidance | 17 | 23 | 1.83e-02 |
| GO:BP | GO:0002063 | chondrocyte development | 17 | 23 | 1.83e-02 |
| GO:BP | GO:0060037 | pharyngeal system development | 17 | 23 | 1.83e-02 |
| GO:BP | GO:0045761 | regulation of adenylate cyclase activity | 17 | 23 | 1.83e-02 |
| GO:BP | GO:0045834 | positive regulation of lipid metabolic process | 48 | 83 | 1.83e-02 |
| GO:BP | GO:0034763 | negative regulation of transmembrane transport | 48 | 83 | 1.83e-02 |
| GO:BP | GO:0046847 | filopodium assembly | 33 | 53 | 1.84e-02 |
| GO:BP | GO:0003006 | developmental process involved in reproduction | 270 | 573 | 1.86e-02 |
| GO:BP | GO:0070509 | calcium ion import | 34 | 55 | 1.87e-02 |
| GO:BP | GO:0042476 | odontogenesis | 46 | 79 | 1.87e-02 |
| GO:BP | GO:0043393 | regulation of protein binding | 62 | 112 | 1.88e-02 |
| GO:BP | GO:1901184 | regulation of ERBB signaling pathway | 35 | 57 | 1.89e-02 |
| GO:BP | GO:0071260 | cellular response to mechanical stimulus | 35 | 57 | 1.89e-02 |
| GO:BP | GO:0046849 | bone remodeling | 36 | 59 | 1.91e-02 |
| GO:BP | GO:0048145 | regulation of fibroblast proliferation | 43 | 73 | 1.91e-02 |
| GO:BP | GO:0043535 | regulation of blood vessel endothelial cell migration | 42 | 71 | 1.92e-02 |
| GO:BP | GO:0051928 | positive regulation of calcium ion transport | 42 | 71 | 1.92e-02 |
| GO:BP | GO:0099084 | postsynaptic specialization organization | 23 | 34 | 1.94e-02 |
| GO:BP | GO:0051592 | response to calcium ion | 60 | 108 | 1.96e-02 |
| GO:BP | GO:0006869 | lipid transport | 131 | 261 | 1.96e-02 |
| GO:BP | GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 78 | 146 | 1.98e-02 |
| GO:BP | GO:1901652 | response to peptide | 179 | 368 | 2.05e-02 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | 709 | 1595 | 2.05e-02 |
| GO:BP | GO:0030902 | hindbrain development | 58 | 104 | 2.05e-02 |
| GO:BP | GO:0022607 | cellular component assembly | 1009 | 2305 | 2.05e-02 |
| GO:BP | GO:2001259 | positive regulation of cation channel activity | 24 | 36 | 2.07e-02 |
| GO:BP | GO:0048662 | negative regulation of smooth muscle cell proliferation | 24 | 36 | 2.07e-02 |
| GO:BP | GO:1902904 | negative regulation of supramolecular fiber organization | 68 | 125 | 2.07e-02 |
| GO:BP | GO:0002763 | positive regulation of myeloid leukocyte differentiation | 24 | 36 | 2.07e-02 |
| GO:BP | GO:1904019 | epithelial cell apoptotic process | 57 | 102 | 2.09e-02 |
| GO:BP | GO:0001956 | positive regulation of neurotransmitter secretion | 11 | 13 | 2.09e-02 |
| GO:BP | GO:0046321 | positive regulation of fatty acid oxidation | 11 | 13 | 2.09e-02 |
| GO:BP | GO:0046579 | positive regulation of Ras protein signal transduction | 11 | 13 | 2.09e-02 |
| GO:BP | GO:0060351 | cartilage development involved in endochondral bone morphogenesis | 18 | 25 | 2.10e-02 |
| GO:BP | GO:0032232 | negative regulation of actin filament bundle assembly | 18 | 25 | 2.10e-02 |
| GO:BP | GO:0038094 | Fc-gamma receptor signaling pathway | 14 | 18 | 2.11e-02 |
| GO:BP | GO:0032925 | regulation of activin receptor signaling pathway | 14 | 18 | 2.11e-02 |
| GO:BP | GO:0051968 | positive regulation of synaptic transmission, glutamatergic | 14 | 18 | 2.11e-02 |
| GO:BP | GO:0043113 | receptor clustering | 25 | 38 | 2.18e-02 |
| GO:BP | GO:0030217 | T cell differentiation | 95 | 183 | 2.18e-02 |
| GO:BP | GO:0045103 | intermediate filament-based process | 25 | 38 | 2.18e-02 |
| GO:BP | GO:0051480 | regulation of cytosolic calcium ion concentration | 25 | 38 | 2.18e-02 |
| GO:BP | GO:0061024 | membrane organization | 292 | 625 | 2.20e-02 |
| GO:BP | GO:1902905 | positive regulation of supramolecular fiber organization | 74 | 138 | 2.20e-02 |
| GO:BP | GO:0072523 | purine-containing compound catabolic process | 65 | 119 | 2.22e-02 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | 400 | 874 | 2.24e-02 |
| GO:BP | GO:0001816 | cytokine production | 211 | 441 | 2.30e-02 |
| GO:BP | GO:0021591 | ventricular system development | 19 | 27 | 2.38e-02 |
| GO:BP | GO:0120033 | negative regulation of plasma membrane bounded cell projection assembly | 19 | 27 | 2.38e-02 |
| GO:BP | GO:0010464 | regulation of mesenchymal cell proliferation | 19 | 27 | 2.38e-02 |
| GO:BP | GO:0031334 | positive regulation of protein-containing complex assembly | 79 | 149 | 2.38e-02 |
| GO:BP | GO:0018193 | peptidyl-amino acid modification | 261 | 555 | 2.42e-02 |
| GO:BP | GO:0002682 | regulation of immune system process | 397 | 868 | 2.44e-02 |
| GO:BP | GO:0001817 | regulation of cytokine production | 209 | 437 | 2.45e-02 |
| GO:BP | GO:0072089 | stem cell proliferation | 48 | 84 | 2.46e-02 |
| GO:BP | GO:0009261 | ribonucleotide catabolic process | 61 | 111 | 2.46e-02 |
| GO:BP | GO:0070613 | regulation of protein processing | 28 | 44 | 2.46e-02 |
| GO:BP | GO:0045664 | regulation of neuron differentiation | 70 | 130 | 2.47e-02 |
| GO:BP | GO:0046129 | purine ribonucleoside biosynthetic process | 9 | 10 | 2.49e-02 |
| GO:BP | GO:0002093 | auditory receptor cell morphogenesis | 9 | 10 | 2.49e-02 |
| GO:BP | GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway | 9 | 10 | 2.49e-02 |
| GO:BP | GO:0030431 | sleep | 9 | 10 | 2.49e-02 |
| GO:BP | GO:0042451 | purine nucleoside biosynthetic process | 9 | 10 | 2.49e-02 |
| GO:BP | GO:0042455 | ribonucleoside biosynthetic process | 9 | 10 | 2.49e-02 |
| GO:BP | GO:0045906 | negative regulation of vasoconstriction | 9 | 10 | 2.49e-02 |
| GO:BP | GO:0071625 | vocalization behavior | 9 | 10 | 2.49e-02 |
| GO:BP | GO:0099149 | regulation of postsynaptic neurotransmitter receptor internalization | 9 | 10 | 2.49e-02 |
| GO:BP | GO:0022410 | circadian sleep/wake cycle process | 9 | 10 | 2.49e-02 |
| GO:BP | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | 15 | 20 | 2.60e-02 |
| GO:BP | GO:0035024 | negative regulation of Rho protein signal transduction | 15 | 20 | 2.60e-02 |
| GO:BP | GO:0031281 | positive regulation of cyclase activity | 15 | 20 | 2.60e-02 |
| GO:BP | GO:2000114 | regulation of establishment of cell polarity | 15 | 20 | 2.60e-02 |
| GO:BP | GO:0086005 | ventricular cardiac muscle cell action potential | 20 | 29 | 2.60e-02 |
| GO:BP | GO:0086019 | cell-cell signaling involved in cardiac conduction | 20 | 29 | 2.60e-02 |
| GO:BP | GO:0010761 | fibroblast migration | 31 | 50 | 2.61e-02 |
| GO:BP | GO:0051606 | detection of stimulus | 58 | 105 | 2.62e-02 |
| GO:BP | GO:0048709 | oligodendrocyte differentiation | 42 | 72 | 2.63e-02 |
| GO:BP | GO:0055013 | cardiac muscle cell development | 42 | 72 | 2.63e-02 |
| GO:BP | GO:0001558 | regulation of cell growth | 158 | 323 | 2.63e-02 |
| GO:BP | GO:1904063 | negative regulation of cation transmembrane transport | 32 | 52 | 2.64e-02 |
| GO:BP | GO:0042475 | odontogenesis of dentin-containing tooth | 33 | 54 | 2.66e-02 |
| GO:BP | GO:0032835 | glomerulus development | 33 | 54 | 2.66e-02 |
| GO:BP | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 35 | 58 | 2.70e-02 |
| GO:BP | GO:0010565 | regulation of cellular ketone metabolic process | 55 | 99 | 2.81e-02 |
| GO:BP | GO:0070296 | sarcoplasmic reticulum calcium ion transport | 21 | 31 | 2.81e-02 |
| GO:BP | GO:0060391 | positive regulation of SMAD protein signal transduction | 21 | 31 | 2.81e-02 |
| GO:BP | GO:0021955 | central nervous system neuron axonogenesis | 21 | 31 | 2.81e-02 |
| GO:BP | GO:0050863 | regulation of T cell activation | 104 | 204 | 2.82e-02 |
| GO:BP | GO:0009913 | epidermal cell differentiation | 64 | 118 | 2.89e-02 |
| GO:BP | GO:0014047 | glutamate secretion | 12 | 15 | 2.89e-02 |
| GO:BP | GO:1900242 | regulation of synaptic vesicle endocytosis | 12 | 15 | 2.89e-02 |
| GO:BP | GO:0098877 | neurotransmitter receptor transport to plasma membrane | 12 | 15 | 2.89e-02 |
| GO:BP | GO:0001759 | organ induction | 12 | 15 | 2.89e-02 |
| GO:BP | GO:0003188 | heart valve formation | 12 | 15 | 2.89e-02 |
| GO:BP | GO:1902932 | positive regulation of alcohol biosynthetic process | 12 | 15 | 2.89e-02 |
| GO:BP | GO:0060571 | morphogenesis of an epithelial fold | 12 | 15 | 2.89e-02 |
| GO:BP | GO:0097091 | synaptic vesicle clustering | 12 | 15 | 2.89e-02 |
| GO:BP | GO:0009166 | nucleotide catabolic process | 72 | 135 | 2.89e-02 |
| GO:BP | GO:0070571 | negative regulation of neuron projection regeneration | 12 | 15 | 2.89e-02 |
| GO:BP | GO:0050870 | positive regulation of T cell activation | 72 | 135 | 2.89e-02 |
| GO:BP | GO:0046128 | purine ribonucleoside metabolic process | 12 | 15 | 2.89e-02 |
| GO:BP | GO:0090103 | cochlea morphogenesis | 12 | 15 | 2.89e-02 |
| GO:BP | GO:0033993 | response to lipid | 268 | 573 | 2.92e-02 |
| GO:BP | GO:0002684 | positive regulation of immune system process | 271 | 580 | 2.96e-02 |
| GO:BP | GO:0008154 | actin polymerization or depolymerization | 78 | 148 | 2.98e-02 |
| GO:BP | GO:0046635 | positive regulation of alpha-beta T cell activation | 22 | 33 | 2.98e-02 |
| GO:BP | GO:0060343 | trabecula formation | 16 | 22 | 3.01e-02 |
| GO:BP | GO:0002021 | response to dietary excess | 16 | 22 | 3.01e-02 |
| GO:BP | GO:0030279 | negative regulation of ossification | 16 | 22 | 3.01e-02 |
| GO:BP | GO:0048499 | synaptic vesicle membrane organization | 16 | 22 | 3.01e-02 |
| GO:BP | GO:0000082 | G1/S transition of mitotic cell cycle | 95 | 185 | 3.13e-02 |
| GO:BP | GO:0086091 | regulation of heart rate by cardiac conduction | 23 | 35 | 3.16e-02 |
| GO:BP | GO:0015698 | inorganic anion transport | 48 | 85 | 3.24e-02 |
| GO:BP | GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 47 | 83 | 3.30e-02 |
| GO:BP | GO:0015800 | acidic amino acid transport | 24 | 37 | 3.31e-02 |
| GO:BP | GO:0045104 | intermediate filament cytoskeleton organization | 24 | 37 | 3.31e-02 |
| GO:BP | GO:0046637 | regulation of alpha-beta T cell differentiation | 24 | 37 | 3.31e-02 |
| GO:BP | GO:0014074 | response to purine-containing compound | 58 | 106 | 3.36e-02 |
| GO:BP | GO:0009154 | purine ribonucleotide catabolic process | 58 | 106 | 3.36e-02 |
| GO:BP | GO:0022011 | myelination in peripheral nervous system | 17 | 24 | 3.43e-02 |
| GO:BP | GO:0048679 | regulation of axon regeneration | 17 | 24 | 3.43e-02 |
| GO:BP | GO:0040036 | regulation of fibroblast growth factor receptor signaling pathway | 17 | 24 | 3.43e-02 |
| GO:BP | GO:0032292 | peripheral nervous system axon ensheathment | 17 | 24 | 3.43e-02 |
| GO:BP | GO:1905332 | positive regulation of morphogenesis of an epithelium | 17 | 24 | 3.43e-02 |
| GO:BP | GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 17 | 24 | 3.43e-02 |
| GO:BP | GO:0060074 | synapse maturation | 17 | 24 | 3.43e-02 |
| GO:BP | GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 57 | 104 | 3.43e-02 |
| GO:BP | GO:0046942 | carboxylic acid transport | 103 | 203 | 3.43e-02 |
| GO:BP | GO:0043068 | positive regulation of programmed cell death | 186 | 388 | 3.44e-02 |
| GO:BP | GO:0006909 | phagocytosis | 73 | 138 | 3.46e-02 |
| GO:BP | GO:0007204 | positive regulation of cytosolic calcium ion concentration | 43 | 75 | 3.51e-02 |
| GO:BP | GO:1990845 | adaptive thermogenesis | 65 | 121 | 3.51e-02 |
| GO:BP | GO:0045453 | bone resorption | 26 | 41 | 3.51e-02 |
| GO:BP | GO:0031103 | axon regeneration | 26 | 41 | 3.51e-02 |
| GO:BP | GO:0030833 | regulation of actin filament polymerization | 56 | 102 | 3.51e-02 |
| GO:BP | GO:0048871 | multicellular organismal-level homeostasis | 251 | 536 | 3.53e-02 |
| GO:BP | GO:0060349 | bone morphogenesis | 42 | 73 | 3.55e-02 |
| GO:BP | GO:0042093 | T-helper cell differentiation | 27 | 43 | 3.59e-02 |
| GO:BP | GO:1903034 | regulation of response to wounding | 64 | 119 | 3.59e-02 |
| GO:BP | GO:0002294 | CD4-positive, alpha-beta T cell differentiation involved in immune response | 27 | 43 | 3.59e-02 |
| GO:BP | GO:0002293 | alpha-beta T cell differentiation involved in immune response | 27 | 43 | 3.59e-02 |
| GO:BP | GO:0045214 | sarcomere organization | 27 | 43 | 3.59e-02 |
| GO:BP | GO:0002287 | alpha-beta T cell activation involved in immune response | 27 | 43 | 3.59e-02 |
| GO:BP | GO:0060392 | negative regulation of SMAD protein signal transduction | 13 | 17 | 3.65e-02 |
| GO:BP | GO:0072673 | lamellipodium morphogenesis | 13 | 17 | 3.65e-02 |
| GO:BP | GO:0048670 | regulation of collateral sprouting | 13 | 17 | 3.65e-02 |
| GO:BP | GO:0042100 | B cell proliferation | 28 | 45 | 3.65e-02 |
| GO:BP | GO:0061323 | cell proliferation involved in heart morphogenesis | 13 | 17 | 3.65e-02 |
| GO:BP | GO:2000136 | regulation of cell proliferation involved in heart morphogenesis | 13 | 17 | 3.65e-02 |
| GO:BP | GO:0043549 | regulation of kinase activity | 172 | 357 | 3.65e-02 |
| GO:BP | GO:0050680 | negative regulation of epithelial cell proliferation | 54 | 98 | 3.66e-02 |
| GO:BP | GO:0030099 | myeloid cell differentiation | 143 | 292 | 3.66e-02 |
| GO:BP | GO:0002067 | glandular epithelial cell differentiation | 29 | 47 | 3.69e-02 |
| GO:BP | GO:1903317 | regulation of protein maturation | 29 | 47 | 3.69e-02 |
| GO:BP | GO:0060291 | long-term synaptic potentiation | 38 | 65 | 3.69e-02 |
| GO:BP | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 18 | 26 | 3.72e-02 |
| GO:BP | GO:0048678 | response to axon injury | 36 | 61 | 3.72e-02 |
| GO:BP | GO:0010092 | specification of animal organ identity | 18 | 26 | 3.72e-02 |
| GO:BP | GO:0060998 | regulation of dendritic spine development | 30 | 49 | 3.72e-02 |
| GO:BP | GO:0033674 | positive regulation of kinase activity | 100 | 197 | 3.72e-02 |
| GO:BP | GO:0032092 | positive regulation of protein binding | 30 | 49 | 3.72e-02 |
| GO:BP | GO:0086064 | cell communication by electrical coupling involved in cardiac conduction | 18 | 26 | 3.72e-02 |
| GO:BP | GO:0007212 | dopamine receptor signaling pathway | 18 | 26 | 3.72e-02 |
| GO:BP | GO:0001936 | regulation of endothelial cell proliferation | 53 | 96 | 3.72e-02 |
| GO:BP | GO:0071621 | granulocyte chemotaxis | 30 | 49 | 3.72e-02 |
| GO:BP | GO:0032271 | regulation of protein polymerization | 83 | 160 | 3.72e-02 |
| GO:BP | GO:0042058 | regulation of epidermal growth factor receptor signaling pathway | 31 | 51 | 3.72e-02 |
| GO:BP | GO:0043954 | cellular component maintenance | 34 | 57 | 3.73e-02 |
| GO:BP | GO:0042310 | vasoconstriction | 33 | 55 | 3.73e-02 |
| GO:BP | GO:0042116 | macrophage activation | 33 | 55 | 3.73e-02 |
| GO:BP | GO:0007589 | body fluid secretion | 34 | 57 | 3.73e-02 |
| GO:BP | GO:0030032 | lamellipodium assembly | 33 | 55 | 3.73e-02 |
| GO:BP | GO:0036211 | protein modification process | 998 | 2291 | 3.75e-02 |
| GO:BP | GO:0036302 | atrioventricular canal development | 10 | 12 | 3.76e-02 |
| GO:BP | GO:0042326 | negative regulation of phosphorylation | 119 | 239 | 3.76e-02 |
| GO:BP | GO:0045651 | positive regulation of macrophage differentiation | 10 | 12 | 3.76e-02 |
| GO:BP | GO:0061154 | endothelial tube morphogenesis | 10 | 12 | 3.76e-02 |
| GO:BP | GO:0033043 | regulation of organelle organization | 431 | 953 | 3.76e-02 |
| GO:BP | GO:0048368 | lateral mesoderm development | 10 | 12 | 3.76e-02 |
| GO:BP | GO:0071871 | response to epinephrine | 10 | 12 | 3.76e-02 |
| GO:BP | GO:0045780 | positive regulation of bone resorption | 10 | 12 | 3.76e-02 |
| GO:BP | GO:0003413 | chondrocyte differentiation involved in endochondral bone morphogenesis | 10 | 12 | 3.76e-02 |
| GO:BP | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis | 10 | 12 | 3.76e-02 |
| GO:BP | GO:0043065 | positive regulation of apoptotic process | 182 | 380 | 3.76e-02 |
| GO:BP | GO:0003159 | morphogenesis of an endothelium | 10 | 12 | 3.76e-02 |
| GO:BP | GO:0099505 | regulation of presynaptic membrane potential | 10 | 12 | 3.76e-02 |
| GO:BP | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 10 | 12 | 3.76e-02 |
| GO:BP | GO:0006955 | immune response | 394 | 867 | 3.77e-02 |
| GO:BP | GO:0022414 | reproductive process | 397 | 874 | 3.77e-02 |
| GO:BP | GO:0007584 | response to nutrient | 61 | 113 | 3.79e-02 |
| GO:BP | GO:0045936 | negative regulation of phosphate metabolic process | 141 | 288 | 3.81e-02 |
| GO:BP | GO:0043534 | blood vessel endothelial cell migration | 51 | 92 | 3.82e-02 |
| GO:BP | GO:1903532 | positive regulation of secretion by cell | 98 | 193 | 3.90e-02 |
| GO:BP | GO:1903706 | regulation of hemopoiesis | 127 | 257 | 3.91e-02 |
| GO:BP | GO:0001819 | positive regulation of cytokine production | 127 | 257 | 3.91e-02 |
| GO:BP | GO:0015849 | organic acid transport | 103 | 204 | 3.92e-02 |
| GO:BP | GO:0033036 | macromolecule localization | 1005 | 2309 | 3.96e-02 |
| GO:BP | GO:1903514 | release of sequestered calcium ion into cytosol by endoplasmic reticulum | 19 | 28 | 3.96e-02 |
| GO:BP | GO:0048483 | autonomic nervous system development | 19 | 28 | 3.96e-02 |
| GO:BP | GO:0014808 | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 19 | 28 | 3.96e-02 |
| GO:BP | GO:0001933 | negative regulation of protein phosphorylation | 112 | 224 | 4.04e-02 |
| GO:BP | GO:0050905 | neuromuscular process | 58 | 107 | 4.11e-02 |
| GO:BP | GO:0030595 | leukocyte chemotaxis | 58 | 107 | 4.11e-02 |
| GO:BP | GO:0001503 | ossification | 147 | 302 | 4.13e-02 |
| GO:BP | GO:0035270 | endocrine system development | 47 | 84 | 4.19e-02 |
| GO:BP | GO:0003338 | metanephros morphogenesis | 14 | 19 | 4.23e-02 |
| GO:BP | GO:0019934 | cGMP-mediated signaling | 14 | 19 | 4.23e-02 |
| GO:BP | GO:0042278 | purine nucleoside metabolic process | 14 | 19 | 4.23e-02 |
| GO:BP | GO:1901201 | regulation of extracellular matrix assembly | 14 | 19 | 4.23e-02 |
| GO:BP | GO:0010878 | cholesterol storage | 14 | 19 | 4.23e-02 |
| GO:BP | GO:0042092 | type 2 immune response | 14 | 19 | 4.23e-02 |
| GO:BP | GO:0003156 | regulation of animal organ formation | 14 | 19 | 4.23e-02 |
| GO:BP | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 14 | 19 | 4.23e-02 |
| GO:BP | GO:0052652 | cyclic purine nucleotide metabolic process | 20 | 30 | 4.23e-02 |
| GO:BP | GO:0062009 | secondary palate development | 14 | 19 | 4.23e-02 |
| GO:BP | GO:0045621 | positive regulation of lymphocyte differentiation | 46 | 82 | 4.25e-02 |
| GO:BP | GO:0007600 | sensory perception | 124 | 251 | 4.29e-02 |
| GO:BP | GO:0010563 | negative regulation of phosphorus metabolic process | 141 | 289 | 4.36e-02 |
| GO:BP | GO:0045637 | regulation of myeloid cell differentiation | 71 | 135 | 4.36e-02 |
| GO:BP | GO:0042113 | B cell activation | 83 | 161 | 4.42e-02 |
| GO:BP | GO:0032869 | cellular response to insulin stimulus | 83 | 161 | 4.42e-02 |
| GO:BP | GO:0055006 | cardiac cell development | 44 | 78 | 4.42e-02 |
| GO:BP | GO:0030282 | bone mineralization | 44 | 78 | 4.42e-02 |
| GO:BP | GO:0031333 | negative regulation of protein-containing complex assembly | 63 | 118 | 4.47e-02 |
| GO:BP | GO:0050714 | positive regulation of protein secretion | 54 | 99 | 4.56e-02 |
| GO:BP | GO:1904018 | positive regulation of vasculature development | 62 | 116 | 4.61e-02 |
| GO:BP | GO:0035272 | exocrine system development | 22 | 34 | 4.63e-02 |
| GO:BP | GO:0030888 | regulation of B cell proliferation | 22 | 34 | 4.63e-02 |
| GO:BP | GO:0090102 | cochlea development | 22 | 34 | 4.63e-02 |
| GO:BP | GO:0060999 | positive regulation of dendritic spine development | 22 | 34 | 4.63e-02 |
| GO:BP | GO:0043666 | regulation of phosphoprotein phosphatase activity | 22 | 34 | 4.63e-02 |
| GO:BP | GO:0003161 | cardiac conduction system development | 22 | 34 | 4.63e-02 |
| GO:BP | GO:0071711 | basement membrane organization | 22 | 34 | 4.63e-02 |
| GO:BP | GO:0002793 | positive regulation of peptide secretion | 41 | 72 | 4.67e-02 |
| GO:BP | GO:0097475 | motor neuron migration | 8 | 9 | 4.69e-02 |
| GO:BP | GO:0003162 | atrioventricular node development | 8 | 9 | 4.69e-02 |
| GO:BP | GO:0050802 | circadian sleep/wake cycle, sleep | 8 | 9 | 4.69e-02 |
| GO:BP | GO:0071361 | cellular response to ethanol | 8 | 9 | 4.69e-02 |
| GO:BP | GO:0060088 | auditory receptor cell stereocilium organization | 8 | 9 | 4.69e-02 |
| GO:BP | GO:0061626 | pharyngeal arch artery morphogenesis | 8 | 9 | 4.69e-02 |
| GO:BP | GO:0001768 | establishment of T cell polarity | 8 | 9 | 4.69e-02 |
| GO:BP | GO:0038065 | collagen-activated signaling pathway | 8 | 9 | 4.69e-02 |
| GO:BP | GO:0030162 | regulation of proteolysis | 197 | 416 | 4.69e-02 |
| GO:BP | GO:0006195 | purine nucleotide catabolic process | 61 | 114 | 4.69e-02 |
| GO:BP | GO:0045766 | positive regulation of angiogenesis | 61 | 114 | 4.69e-02 |
| GO:BP | GO:0045862 | positive regulation of proteolysis | 121 | 245 | 4.69e-02 |
| GO:BP | GO:0030593 | neutrophil chemotaxis | 23 | 36 | 4.75e-02 |
| GO:BP | GO:0061001 | regulation of dendritic spine morphogenesis | 23 | 36 | 4.75e-02 |
| GO:BP | GO:0060443 | mammary gland morphogenesis | 23 | 36 | 4.75e-02 |
| GO:BP | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0023041 | neuronal signal transduction | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0014912 | negative regulation of smooth muscle cell migration | 15 | 21 | 4.75e-02 |
| GO:BP | GO:0032754 | positive regulation of interleukin-5 production | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0031223 | auditory behavior | 6 | 6 | 4.75e-02 |
| GO:BP | GO:1903421 | regulation of synaptic vesicle recycling | 15 | 21 | 4.75e-02 |
| GO:BP | GO:0072173 | metanephric tubule morphogenesis | 6 | 6 | 4.75e-02 |
| GO:BP | GO:1903903 | regulation of establishment of T cell polarity | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0010737 | protein kinase A signaling | 15 | 21 | 4.75e-02 |
| GO:BP | GO:0060710 | chorio-allantoic fusion | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0061037 | negative regulation of cartilage development | 15 | 21 | 4.75e-02 |
| GO:BP | GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0099545 | trans-synaptic signaling by trans-synaptic complex | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0051639 | actin filament network formation | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0050679 | positive regulation of epithelial cell proliferation | 74 | 142 | 4.75e-02 |
| GO:BP | GO:2000192 | negative regulation of fatty acid transport | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0014031 | mesenchymal cell development | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0050861 | positive regulation of B cell receptor signaling pathway | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0060897 | neural plate regionalization | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0003175 | tricuspid valve development | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0043502 | regulation of muscle adaptation | 39 | 68 | 4.75e-02 |
| GO:BP | GO:0098976 | excitatory chemical synaptic transmission | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0003415 | chondrocyte hypertrophy | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0001771 | immunological synapse formation | 6 | 6 | 4.75e-02 |
| GO:BP | GO:0045639 | positive regulation of myeloid cell differentiation | 38 | 66 | 4.77e-02 |
| GO:BP | GO:0051098 | regulation of binding | 101 | 201 | 4.78e-02 |
| GO:BP | GO:0048013 | ephrin receptor signaling pathway | 24 | 38 | 4.78e-02 |
| GO:BP | GO:0051494 | negative regulation of cytoskeleton organization | 67 | 127 | 4.78e-02 |
| GO:BP | GO:2001222 | regulation of neuron migration | 24 | 38 | 4.78e-02 |
| GO:BP | GO:2000117 | negative regulation of cysteine-type endopeptidase activity | 24 | 38 | 4.78e-02 |
| GO:BP | GO:0019217 | regulation of fatty acid metabolic process | 37 | 64 | 4.82e-02 |
| GO:BP | GO:0038166 | angiotensin-activated signaling pathway | 11 | 14 | 4.84e-02 |
| GO:BP | GO:0060142 | regulation of syncytium formation by plasma membrane fusion | 11 | 14 | 4.84e-02 |
| GO:BP | GO:0010763 | positive regulation of fibroblast migration | 11 | 14 | 4.84e-02 |
| GO:BP | GO:0002252 | immune effector process | 145 | 299 | 4.84e-02 |
| GO:BP | GO:1901292 | nucleoside phosphate catabolic process | 73 | 140 | 4.84e-02 |
| GO:BP | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway | 11 | 14 | 4.84e-02 |
| GO:BP | GO:0050954 | sensory perception of mechanical stimulus | 59 | 110 | 4.84e-02 |
| GO:BP | GO:0010885 | regulation of cholesterol storage | 11 | 14 | 4.84e-02 |
| GO:BP | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter | 11 | 14 | 4.84e-02 |
| GO:BP | GO:0006835 | dicarboxylic acid transport | 35 | 60 | 4.91e-02 |
| GO:BP | GO:0048146 | positive regulation of fibroblast proliferation | 26 | 42 | 4.93e-02 |
| GO:BP | GO:0045123 | cellular extravasation | 26 | 42 | 4.93e-02 |
| GO:BP | GO:0051489 | regulation of filopodium assembly | 26 | 42 | 4.93e-02 |
| GO:BP | GO:0048144 | fibroblast proliferation | 49 | 89 | 4.98e-02 |
| GO:BP | GO:0002042 | cell migration involved in sprouting angiogenesis | 27 | 44 | 4.98e-02 |
| GO:BP | GO:0071695 | anatomical structure maturation | 78 | 151 | 4.99e-02 |
ESRnomtable_20k %>%
filter(source=="KEGG", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in ESR nESRgenes_20k") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:04510 | Focal adhesion | 113 | 169 | 2.81e-09 |
| KEGG | KEGG:04020 | Calcium signaling pathway | 107 | 161 | 5.90e-09 |
| KEGG | KEGG:04360 | Axon guidance | 104 | 155 | 5.90e-09 |
| KEGG | KEGG:05200 | Pathways in cancer | 223 | 391 | 5.98e-09 |
| KEGG | KEGG:04024 | cAMP signaling pathway | 98 | 147 | 1.47e-08 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | 106 | 162 | 1.47e-08 |
| KEGG | KEGG:04925 | Aldosterone synthesis and secretion | 57 | 75 | 3.12e-08 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 105 | 162 | 3.12e-08 |
| KEGG | KEGG:04022 | cGMP-PKG signaling pathway | 84 | 129 | 8.83e-07 |
| KEGG | KEGG:04724 | Glutamatergic synapse | 54 | 74 | 8.83e-07 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | 58 | 82 | 1.48e-06 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | 80 | 124 | 2.88e-06 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | 74 | 113 | 2.99e-06 |
| KEGG | KEGG:04911 | Insulin secretion | 46 | 62 | 2.99e-06 |
| KEGG | KEGG:04270 | Vascular smooth muscle contraction | 62 | 92 | 6.32e-06 |
| KEGG | KEGG:04310 | Wnt signaling pathway | 83 | 133 | 1.05e-05 |
| KEGG | KEGG:04924 | Renin secretion | 38 | 50 | 1.06e-05 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | 101 | 169 | 1.16e-05 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | 53 | 77 | 1.18e-05 |
| KEGG | KEGG:04713 | Circadian entrainment | 48 | 68 | 1.18e-05 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | 68 | 105 | 1.18e-05 |
| KEGG | KEGG:04611 | Platelet activation | 59 | 88 | 1.18e-05 |
| KEGG | KEGG:04927 | Cortisol synthesis and secretion | 35 | 46 | 2.12e-05 |
| KEGG | KEGG:04512 | ECM-receptor interaction | 46 | 66 | 3.24e-05 |
| KEGG | KEGG:04750 | Inflammatory mediator regulation of TRP channels | 49 | 72 | 4.35e-05 |
| KEGG | KEGG:04014 | Ras signaling pathway | 96 | 164 | 5.46e-05 |
| KEGG | KEGG:04726 | Serotonergic synapse | 41 | 58 | 5.82e-05 |
| KEGG | KEGG:04725 | Cholinergic synapse | 54 | 82 | 5.84e-05 |
| KEGG | KEGG:04971 | Gastric acid secretion | 37 | 51 | 5.94e-05 |
| KEGG | KEGG:04934 | Cushing syndrome | 73 | 119 | 6.66e-05 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | 137 | 250 | 7.18e-05 |
| KEGG | KEGG:04520 | Adherens junction | 54 | 83 | 8.80e-05 |
| KEGG | KEGG:04970 | Salivary secretion | 38 | 54 | 1.26e-04 |
| KEGG | KEGG:04961 | Endocrine and other factor-regulated calcium reabsorption | 30 | 40 | 1.36e-04 |
| KEGG | KEGG:04974 | Protein digestion and absorption | 39 | 56 | 1.36e-04 |
| KEGG | KEGG:04728 | Dopaminergic synapse | 60 | 97 | 2.51e-04 |
| KEGG | KEGG:04972 | Pancreatic secretion | 39 | 57 | 2.51e-04 |
| KEGG | KEGG:04072 | Phospholipase D signaling pathway | 65 | 107 | 2.61e-04 |
| KEGG | KEGG:04390 | Hippo signaling pathway | 76 | 129 | 2.61e-04 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | 49 | 76 | 2.63e-04 |
| KEGG | KEGG:04929 | GnRH secretion | 35 | 50 | 2.70e-04 |
| KEGG | KEGG:04010 | MAPK signaling pathway | 125 | 231 | 2.92e-04 |
| KEGG | KEGG:05032 | Morphine addiction | 37 | 54 | 3.17e-04 |
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | 44 | 67 | 3.17e-04 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | 82 | 144 | 6.05e-04 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 49 | 78 | 6.17e-04 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | 55 | 90 | 6.81e-04 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | 60 | 100 | 6.92e-04 |
| KEGG | KEGG:04730 | Long-term depression | 28 | 39 | 6.92e-04 |
| KEGG | KEGG:04530 | Tight junction | 74 | 129 | 8.61e-04 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | 89 | 160 | 8.61e-04 |
| KEGG | KEGG:05165 | Human papillomavirus infection | 132 | 252 | 1.05e-03 |
| KEGG | KEGG:04148 | Efferocytosis | 69 | 120 | 1.24e-03 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | 52 | 86 | 1.31e-03 |
| KEGG | KEGG:04371 | Apelin signaling pathway | 61 | 104 | 1.31e-03 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | 57 | 96 | 1.31e-03 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | 77 | 137 | 1.38e-03 |
| KEGG | KEGG:04976 | Bile secretion | 28 | 41 | 2.24e-03 |
| KEGG | KEGG:04923 | Regulation of lipolysis in adipocytes | 28 | 41 | 2.24e-03 |
| KEGG | KEGG:05146 | Amoebiasis | 39 | 62 | 2.38e-03 |
| KEGG | KEGG:05031 | Amphetamine addiction | 30 | 45 | 2.57e-03 |
| KEGG | KEGG:04720 | Long-term potentiation | 33 | 51 | 3.03e-03 |
| KEGG | KEGG:05226 | Gastric cancer | 64 | 113 | 3.09e-03 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | 51 | 87 | 3.68e-03 |
| KEGG | KEGG:04916 | Melanogenesis | 45 | 75 | 3.70e-03 |
| KEGG | KEGG:04814 | Motor proteins | 77 | 141 | 3.89e-03 |
| KEGG | KEGG:00051 | Fructose and mannose metabolism | 19 | 26 | 4.90e-03 |
| KEGG | KEGG:04659 | Th17 cell differentiation | 37 | 60 | 5.06e-03 |
| KEGG | KEGG:04912 | GnRH signaling pathway | 44 | 74 | 5.12e-03 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | 46 | 78 | 5.12e-03 |
| KEGG | KEGG:05224 | Breast cancer | 63 | 113 | 5.26e-03 |
| KEGG | KEGG:04370 | VEGF signaling pathway | 30 | 47 | 6.43e-03 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | 43 | 73 | 6.96e-03 |
| KEGG | KEGG:04012 | ErbB signaling pathway | 44 | 75 | 6.96e-03 |
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | 44 | 75 | 6.96e-03 |
| KEGG | KEGG:05214 | Glioma | 39 | 65 | 6.96e-03 |
| KEGG | KEGG:04540 | Gap junction | 42 | 71 | 6.96e-03 |
| KEGG | KEGG:00000 | KEGG root term | 2317 | 5451 | 7.40e-03 |
| KEGG | KEGG:04740 | Olfactory transduction | 18 | 25 | 7.53e-03 |
| KEGG | KEGG:01522 | Endocrine resistance | 47 | 82 | 9.04e-03 |
| KEGG | KEGG:04727 | GABAergic synapse | 32 | 52 | 9.64e-03 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | 35 | 58 | 9.77e-03 |
| KEGG | KEGG:04152 | AMPK signaling pathway | 56 | 101 | 9.84e-03 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | 65 | 120 | 9.89e-03 |
| KEGG | KEGG:05131 | Shigellosis | 104 | 204 | 9.89e-03 |
| KEGG | KEGG:04930 | Type II diabetes mellitus | 23 | 35 | 1.12e-02 |
| KEGG | KEGG:04721 | Synaptic vesicle cycle | 30 | 49 | 1.35e-02 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | 70 | 132 | 1.35e-02 |
| KEGG | KEGG:04910 | Insulin signaling pathway | 61 | 113 | 1.40e-02 |
| KEGG | KEGG:04380 | Osteoclast differentiation | 51 | 92 | 1.40e-02 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | 50 | 90 | 1.42e-02 |
| KEGG | KEGG:05135 | Yersinia infection | 58 | 107 | 1.48e-02 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | 45 | 80 | 1.57e-02 |
| KEGG | KEGG:05030 | Cocaine addiction | 21 | 32 | 1.60e-02 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | 41 | 72 | 1.68e-02 |
| KEGG | KEGG:00052 | Galactose metabolism | 15 | 21 | 1.71e-02 |
| KEGG | KEGG:00512 | Mucin type O-glycan biosynthesis | 15 | 21 | 1.71e-02 |
| KEGG | KEGG:04931 | Insulin resistance | 50 | 91 | 1.77e-02 |
| KEGG | KEGG:04070 | Phosphatidylinositol signaling system | 46 | 83 | 1.96e-02 |
| KEGG | KEGG:04060 | Cytokine-cytokine receptor interaction | 51 | 94 | 2.24e-02 |
| KEGG | KEGG:04514 | Cell adhesion molecules | 39 | 69 | 2.29e-02 |
| KEGG | KEGG:04973 | Carbohydrate digestion and absorption | 19 | 29 | 2.30e-02 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | 64 | 122 | 2.32e-02 |
| KEGG | KEGG:04071 | Sphingolipid signaling pathway | 55 | 103 | 2.46e-02 |
| KEGG | KEGG:04650 | Natural killer cell mediated cytotoxicity | 31 | 53 | 2.54e-02 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | 41 | 74 | 2.85e-02 |
| KEGG | KEGG:05211 | Renal cell carcinoma | 35 | 62 | 3.26e-02 |
| KEGG | KEGG:04960 | Aldosterone-regulated sodium reabsorption | 16 | 24 | 3.26e-02 |
| KEGG | KEGG:05210 | Colorectal cancer | 44 | 81 | 3.35e-02 |
| KEGG | KEGG:04913 | Ovarian steroidogenesis | 17 | 26 | 3.35e-02 |
| KEGG | KEGG:05218 | Melanoma | 32 | 56 | 3.39e-02 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | 57 | 109 | 3.45e-02 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | 57 | 109 | 3.45e-02 |
| KEGG | KEGG:04213 | Longevity regulating pathway - multiple species | 29 | 50 | 3.48e-02 |
| KEGG | KEGG:05212 | Pancreatic cancer | 39 | 71 | 3.73e-02 |
| KEGG | KEGG:04150 | mTOR signaling pathway | 66 | 129 | 3.73e-02 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | 53 | 101 | 3.86e-02 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | 75 | 149 | 3.88e-02 |
| KEGG | KEGG:04260 | Cardiac muscle contraction | 35 | 63 | 4.04e-02 |
| KEGG | KEGG:05222 | Small cell lung cancer | 44 | 82 | 4.04e-02 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | 68 | 134 | 4.07e-02 |
| KEGG | KEGG:04614 | Renin-angiotensin system | 8 | 10 | 4.18e-02 |
| KEGG | KEGG:05033 | Nicotine addiction | 8 | 10 | 4.18e-02 |
| KEGG | KEGG:04340 | Hedgehog signaling pathway | 28 | 49 | 4.61e-02 |
| KEGG | KEGG:05142 | Chagas disease | 39 | 72 | 4.61e-02 |
| KEGG | KEGG:03320 | PPAR signaling pathway | 27 | 47 | 4.67e-02 |
| KEGG | KEGG:04392 | Hippo signaling pathway - multiple species | 16 | 25 | 4.75e-02 |
| KEGG | KEGG:05219 | Bladder cancer | 21 | 35 | 4.97e-02 |
ESR peaks overlapping enhancers
# ESR_resgenes_20k_enh <- gost(query = unique(ESR_enh_peaks_20k$NCBI_gene),
# organism = "hsapiens",
# significant = FALSE,
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = background_df$ENTREZID,
# sources=c("GO:BP","KEGG"))
# saveRDS(ESR_resgenes_20k_enh,"data/GO_KEGG_analysis/ESR_resgenes_20k_enh.RDS")
# ESRnom <- gostplot(ESR_resgenes_20k_enh, capped = FALSE, interactive = TRUE)
# ESRnom
ESRnomtable_20k_enh <- ESR_resgenes_20k_enh$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
ESRnomtable_20k_enh %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in ESR neargenes_20k" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0032501 | multicellular organismal process | 623 | 4504 | 2.35e-19 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 318 | 1924 | 1.69e-17 |
| GO:BP | GO:0030154 | cell differentiation | 415 | 2803 | 1.63e-15 |
| GO:BP | GO:0048856 | anatomical structure development | 536 | 3867 | 1.63e-15 |
| GO:BP | GO:0048869 | cellular developmental process | 415 | 2804 | 1.63e-15 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 299 | 1844 | 2.56e-15 |
| GO:BP | GO:0032502 | developmental process | 567 | 4179 | 4.03e-15 |
| GO:BP | GO:0007154 | cell communication | 533 | 3983 | 2.17e-12 |
| GO:BP | GO:0050896 | response to stimulus | 680 | 5379 | 3.74e-12 |
| GO:BP | GO:0072359 | circulatory system development | 161 | 864 | 4.11e-12 |
| GO:BP | GO:0048731 | system development | 389 | 2719 | 5.72e-12 |
| GO:BP | GO:0007275 | multicellular organism development | 440 | 3170 | 5.72e-12 |
| GO:BP | GO:0023052 | signaling | 523 | 3918 | 5.72e-12 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | 156 | 837 | 8.14e-12 |
| GO:BP | GO:0050789 | regulation of biological process | 891 | 7516 | 9.21e-12 |
| GO:BP | GO:0003013 | circulatory system process | 96 | 426 | 1.43e-11 |
| GO:BP | GO:0008015 | blood circulation | 85 | 357 | 1.64e-11 |
| GO:BP | GO:0065007 | biological regulation | 908 | 7734 | 5.15e-11 |
| GO:BP | GO:0003008 | system process | 193 | 1139 | 5.57e-11 |
| GO:BP | GO:0007165 | signal transduction | 483 | 3611 | 6.96e-11 |
| GO:BP | GO:0030029 | actin filament-based process | 125 | 640 | 9.97e-11 |
| GO:BP | GO:0050793 | regulation of developmental process | 260 | 1697 | 2.48e-10 |
| GO:BP | GO:0061061 | muscle structure development | 109 | 536 | 2.48e-10 |
| GO:BP | GO:0048468 | cell development | 282 | 1886 | 3.66e-10 |
| GO:BP | GO:0060047 | heart contraction | 54 | 194 | 9.51e-10 |
| GO:BP | GO:0051716 | cellular response to stimulus | 587 | 4640 | 1.20e-09 |
| GO:BP | GO:0050794 | regulation of cellular process | 842 | 7153 | 2.34e-09 |
| GO:BP | GO:0048518 | positive regulation of biological process | 547 | 4301 | 5.59e-09 |
| GO:BP | GO:0003015 | heart process | 54 | 204 | 6.73e-09 |
| GO:BP | GO:0009888 | tissue development | 211 | 1348 | 6.73e-09 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 192 | 1197 | 7.02e-09 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 508 | 3954 | 9.71e-09 |
| GO:BP | GO:0048519 | negative regulation of biological process | 487 | 3764 | 1.11e-08 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 170 | 1035 | 1.58e-08 |
| GO:BP | GO:0008016 | regulation of heart contraction | 46 | 165 | 2.64e-08 |
| GO:BP | GO:0016477 | cell migration | 165 | 1011 | 4.95e-08 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | 106 | 566 | 5.58e-08 |
| GO:BP | GO:0003012 | muscle system process | 71 | 325 | 6.70e-08 |
| GO:BP | GO:0035239 | tube morphogenesis | 115 | 638 | 9.94e-08 |
| GO:BP | GO:0040011 | locomotion | 137 | 805 | 1.11e-07 |
| GO:BP | GO:0042692 | muscle cell differentiation | 70 | 323 | 1.17e-07 |
| GO:BP | GO:2000145 | regulation of cell motility | 123 | 700 | 1.17e-07 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 457 | 3550 | 1.22e-07 |
| GO:BP | GO:0044057 | regulation of system process | 79 | 384 | 1.22e-07 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | 259 | 1801 | 1.39e-07 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | 91 | 469 | 1.39e-07 |
| GO:BP | GO:0035295 | tube development | 134 | 787 | 1.44e-07 |
| GO:BP | GO:0055001 | muscle cell development | 44 | 163 | 1.50e-07 |
| GO:BP | GO:0040012 | regulation of locomotion | 125 | 720 | 1.56e-07 |
| GO:BP | GO:0030334 | regulation of cell migration | 118 | 668 | 1.62e-07 |
| GO:BP | GO:1903522 | regulation of blood circulation | 49 | 194 | 1.90e-07 |
| GO:BP | GO:0051146 | striated muscle cell differentiation | 55 | 234 | 3.18e-07 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | 109 | 609 | 3.24e-07 |
| GO:BP | GO:0048514 | blood vessel morphogenesis | 87 | 450 | 3.38e-07 |
| GO:BP | GO:0030048 | actin filament-based movement | 33 | 107 | 4.41e-07 |
| GO:BP | GO:0008283 | cell population proliferation | 197 | 1306 | 4.49e-07 |
| GO:BP | GO:0001568 | blood vessel development | 97 | 525 | 4.54e-07 |
| GO:BP | GO:0048870 | cell motility | 174 | 1120 | 4.71e-07 |
| GO:BP | GO:0070252 | actin-mediated cell contraction | 29 | 87 | 5.05e-07 |
| GO:BP | GO:0048513 | animal organ development | 279 | 2004 | 5.79e-07 |
| GO:BP | GO:0007507 | heart development | 93 | 499 | 5.79e-07 |
| GO:BP | GO:0001944 | vasculature development | 100 | 552 | 6.93e-07 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | 163 | 1040 | 7.78e-07 |
| GO:BP | GO:0060048 | cardiac muscle contraction | 34 | 116 | 9.47e-07 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | 121 | 717 | 1.26e-06 |
| GO:BP | GO:0009887 | animal organ morphogenesis | 115 | 673 | 1.45e-06 |
| GO:BP | GO:0060537 | muscle tissue development | 69 | 339 | 1.53e-06 |
| GO:BP | GO:0051093 | negative regulation of developmental process | 108 | 622 | 1.68e-06 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | 166 | 1077 | 1.71e-06 |
| GO:BP | GO:0007155 | cell adhesion | 149 | 941 | 1.73e-06 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | 150 | 951 | 1.98e-06 |
| GO:BP | GO:0045595 | regulation of cell differentiation | 165 | 1073 | 2.15e-06 |
| GO:BP | GO:0006936 | muscle contraction | 56 | 255 | 2.18e-06 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 356 | 2717 | 2.43e-06 |
| GO:BP | GO:0030155 | regulation of cell adhesion | 92 | 508 | 2.45e-06 |
| GO:BP | GO:0001667 | ameboidal-type cell migration | 69 | 344 | 2.50e-06 |
| GO:BP | GO:0000902 | cell morphogenesis | 119 | 713 | 2.72e-06 |
| GO:BP | GO:0014706 | striated muscle tissue development | 49 | 213 | 3.34e-06 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | 47 | 201 | 3.68e-06 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | 54 | 248 | 4.82e-06 |
| GO:BP | GO:0051241 | negative regulation of multicellular organismal process | 116 | 706 | 9.39e-06 |
| GO:BP | GO:0006941 | striated muscle contraction | 37 | 146 | 1.14e-05 |
| GO:BP | GO:0097435 | supramolecular fiber organization | 106 | 633 | 1.29e-05 |
| GO:BP | GO:0023051 | regulation of signaling | 320 | 2438 | 1.32e-05 |
| GO:BP | GO:0001525 | angiogenesis | 72 | 381 | 1.38e-05 |
| GO:BP | GO:0065009 | regulation of molecular function | 188 | 1299 | 1.64e-05 |
| GO:BP | GO:0010646 | regulation of cell communication | 320 | 2444 | 1.64e-05 |
| GO:BP | GO:0003007 | heart morphogenesis | 48 | 218 | 1.70e-05 |
| GO:BP | GO:0090130 | tissue migration | 52 | 247 | 2.38e-05 |
| GO:BP | GO:0070848 | response to growth factor | 93 | 547 | 3.56e-05 |
| GO:BP | GO:0002027 | regulation of heart rate | 25 | 83 | 3.56e-05 |
| GO:BP | GO:0098657 | import into cell | 102 | 622 | 5.64e-05 |
| GO:BP | GO:0061337 | cardiac conduction | 25 | 85 | 5.74e-05 |
| GO:BP | GO:0065008 | regulation of biological quality | 254 | 1893 | 6.06e-05 |
| GO:BP | GO:0071417 | cellular response to organonitrogen compound | 78 | 442 | 6.81e-05 |
| GO:BP | GO:0009605 | response to external stimulus | 215 | 1559 | 7.27e-05 |
| GO:BP | GO:0090132 | epithelium migration | 50 | 243 | 7.54e-05 |
| GO:BP | GO:0010631 | epithelial cell migration | 50 | 243 | 7.54e-05 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | 97 | 588 | 7.57e-05 |
| GO:BP | GO:0031032 | actomyosin structure organization | 41 | 184 | 8.32e-05 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | 89 | 528 | 8.37e-05 |
| GO:BP | GO:0051094 | positive regulation of developmental process | 137 | 913 | 1.13e-04 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | 82 | 479 | 1.17e-04 |
| GO:BP | GO:0048568 | embryonic organ development | 58 | 303 | 1.20e-04 |
| GO:BP | GO:0042221 | response to chemical | 298 | 2304 | 1.33e-04 |
| GO:BP | GO:0010632 | regulation of epithelial cell migration | 41 | 188 | 1.41e-04 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | 78 | 452 | 1.48e-04 |
| GO:BP | GO:0009966 | regulation of signal transduction | 282 | 2166 | 1.54e-04 |
| GO:BP | GO:0010243 | response to organonitrogen compound | 108 | 685 | 1.54e-04 |
| GO:BP | GO:0071526 | semaphorin-plexin signaling pathway | 16 | 43 | 1.64e-04 |
| GO:BP | GO:0003205 | cardiac chamber development | 35 | 151 | 1.76e-04 |
| GO:BP | GO:0031325 | positive regulation of cellular metabolic process | 300 | 2333 | 1.91e-04 |
| GO:BP | GO:0003231 | cardiac ventricle development | 29 | 115 | 2.10e-04 |
| GO:BP | GO:0009628 | response to abiotic stimulus | 123 | 811 | 2.13e-04 |
| GO:BP | GO:0007517 | muscle organ development | 52 | 267 | 2.20e-04 |
| GO:BP | GO:0071310 | cellular response to organic substance | 181 | 1297 | 2.45e-04 |
| GO:BP | GO:0003206 | cardiac chamber morphogenesis | 28 | 110 | 2.45e-04 |
| GO:BP | GO:0035556 | intracellular signal transduction | 256 | 1951 | 2.67e-04 |
| GO:BP | GO:0048729 | tissue morphogenesis | 77 | 453 | 2.78e-04 |
| GO:BP | GO:2000147 | positive regulation of cell motility | 71 | 408 | 2.81e-04 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | 19 | 60 | 2.85e-04 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | 233 | 1751 | 2.86e-04 |
| GO:BP | GO:0040017 | positive regulation of locomotion | 72 | 416 | 2.87e-04 |
| GO:BP | GO:0030239 | myofibril assembly | 20 | 66 | 3.35e-04 |
| GO:BP | GO:0061614 | miRNA transcription | 19 | 61 | 3.63e-04 |
| GO:BP | GO:0007010 | cytoskeleton organization | 162 | 1146 | 3.76e-04 |
| GO:BP | GO:0014888 | striated muscle adaptation | 15 | 41 | 3.76e-04 |
| GO:BP | GO:0090257 | regulation of muscle system process | 38 | 177 | 4.07e-04 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | 94 | 591 | 4.20e-04 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | 329 | 2622 | 4.43e-04 |
| GO:BP | GO:1901698 | response to nitrogen compound | 112 | 736 | 4.49e-04 |
| GO:BP | GO:0141124 | intracellular signaling cassette | 181 | 1314 | 4.90e-04 |
| GO:BP | GO:0055002 | striated muscle cell development | 20 | 68 | 5.16e-04 |
| GO:BP | GO:0030335 | positive regulation of cell migration | 68 | 395 | 5.83e-04 |
| GO:BP | GO:0045765 | regulation of angiogenesis | 40 | 194 | 6.23e-04 |
| GO:BP | GO:0086003 | cardiac muscle cell contraction | 19 | 64 | 7.16e-04 |
| GO:BP | GO:0048644 | muscle organ morphogenesis | 19 | 64 | 7.16e-04 |
| GO:BP | GO:0070482 | response to oxygen levels | 50 | 265 | 7.16e-04 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 107 | 704 | 7.20e-04 |
| GO:BP | GO:0010720 | positive regulation of cell development | 56 | 309 | 7.42e-04 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 304 | 2415 | 8.12e-04 |
| GO:BP | GO:1901342 | regulation of vasculature development | 40 | 198 | 9.82e-04 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | 153 | 1093 | 1.06e-03 |
| GO:BP | GO:0043500 | muscle adaptation | 23 | 89 | 1.10e-03 |
| GO:BP | GO:0006915 | apoptotic process | 186 | 1377 | 1.10e-03 |
| GO:BP | GO:0006937 | regulation of muscle contraction | 29 | 126 | 1.10e-03 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | 20 | 72 | 1.19e-03 |
| GO:BP | GO:0060415 | muscle tissue morphogenesis | 18 | 61 | 1.23e-03 |
| GO:BP | GO:0022008 | neurogenesis | 171 | 1251 | 1.24e-03 |
| GO:BP | GO:0007264 | small GTPase-mediated signal transduction | 66 | 390 | 1.24e-03 |
| GO:BP | GO:0040013 | negative regulation of locomotion | 46 | 243 | 1.30e-03 |
| GO:BP | GO:0003018 | vascular process in circulatory system | 39 | 194 | 1.31e-03 |
| GO:BP | GO:0048589 | developmental growth | 80 | 501 | 1.50e-03 |
| GO:BP | GO:0010033 | response to organic substance | 226 | 1736 | 1.50e-03 |
| GO:BP | GO:0014902 | myotube differentiation | 22 | 85 | 1.51e-03 |
| GO:BP | GO:0071260 | cellular response to mechanical stimulus | 17 | 57 | 1.68e-03 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | 239 | 1856 | 1.76e-03 |
| GO:BP | GO:0007015 | actin filament organization | 61 | 357 | 1.77e-03 |
| GO:BP | GO:0086001 | cardiac muscle cell action potential | 18 | 63 | 1.86e-03 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | 116 | 796 | 1.86e-03 |
| GO:BP | GO:1902894 | negative regulation of miRNA transcription | 10 | 23 | 1.89e-03 |
| GO:BP | GO:0042092 | type 2 immune response | 9 | 19 | 2.02e-03 |
| GO:BP | GO:0014074 | response to purine-containing compound | 25 | 106 | 2.31e-03 |
| GO:BP | GO:0008360 | regulation of cell shape | 25 | 106 | 2.31e-03 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | 181 | 1354 | 2.33e-03 |
| GO:BP | GO:0022604 | regulation of cell morphogenesis | 38 | 193 | 2.44e-03 |
| GO:BP | GO:0036293 | response to decreased oxygen levels | 45 | 243 | 2.51e-03 |
| GO:BP | GO:0031328 | positive regulation of cellular biosynthetic process | 236 | 1841 | 2.52e-03 |
| GO:BP | GO:0012501 | programmed cell death | 188 | 1419 | 2.69e-03 |
| GO:BP | GO:0009790 | embryo development | 118 | 821 | 2.76e-03 |
| GO:BP | GO:0051172 | negative regulation of nitrogen compound metabolic process | 212 | 1633 | 2.99e-03 |
| GO:BP | GO:0034330 | cell junction organization | 84 | 545 | 3.09e-03 |
| GO:BP | GO:0008219 | cell death | 188 | 1423 | 3.09e-03 |
| GO:BP | GO:0009725 | response to hormone | 92 | 610 | 3.16e-03 |
| GO:BP | GO:0086005 | ventricular cardiac muscle cell action potential | 11 | 29 | 3.26e-03 |
| GO:BP | GO:0016525 | negative regulation of angiogenesis | 18 | 66 | 3.30e-03 |
| GO:BP | GO:0001666 | response to hypoxia | 43 | 232 | 3.37e-03 |
| GO:BP | GO:0035272 | exocrine system development | 12 | 34 | 3.45e-03 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | 161 | 1193 | 3.63e-03 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 237 | 1862 | 3.63e-03 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | 229 | 1791 | 3.67e-03 |
| GO:BP | GO:0048598 | embryonic morphogenesis | 68 | 422 | 3.73e-03 |
| GO:BP | GO:0032879 | regulation of localization | 189 | 1439 | 3.87e-03 |
| GO:BP | GO:2000629 | negative regulation of miRNA metabolic process | 10 | 25 | 3.87e-03 |
| GO:BP | GO:1901343 | negative regulation of vasculature development | 18 | 67 | 3.87e-03 |
| GO:BP | GO:2000181 | negative regulation of blood vessel morphogenesis | 18 | 67 | 3.87e-03 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | 135 | 973 | 3.94e-03 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | 146 | 1067 | 3.95e-03 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | 165 | 1231 | 3.96e-03 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | 134 | 965 | 3.96e-03 |
| GO:BP | GO:0048699 | generation of neurons | 147 | 1076 | 3.96e-03 |
| GO:BP | GO:0051960 | regulation of nervous system development | 57 | 339 | 4.09e-03 |
| GO:BP | GO:0007162 | negative regulation of cell adhesion | 36 | 185 | 4.21e-03 |
| GO:BP | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 72 | 456 | 4.22e-03 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | 165 | 1234 | 4.34e-03 |
| GO:BP | GO:0086091 | regulation of heart rate by cardiac conduction | 12 | 35 | 4.34e-03 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | 69 | 433 | 4.34e-03 |
| GO:BP | GO:0023057 | negative regulation of signaling | 142 | 1036 | 4.34e-03 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 156 | 1157 | 4.46e-03 |
| GO:BP | GO:0060284 | regulation of cell development | 86 | 570 | 4.67e-03 |
| GO:BP | GO:0051049 | regulation of transport | 149 | 1098 | 4.67e-03 |
| GO:BP | GO:0007399 | nervous system development | 226 | 1775 | 4.81e-03 |
| GO:BP | GO:0007267 | cell-cell signaling | 147 | 1082 | 4.88e-03 |
| GO:BP | GO:0032944 | regulation of mononuclear cell proliferation | 26 | 119 | 5.19e-03 |
| GO:BP | GO:0006942 | regulation of striated muscle contraction | 20 | 81 | 5.26e-03 |
| GO:BP | GO:0030001 | metal ion transport | 80 | 524 | 5.27e-03 |
| GO:BP | GO:0090288 | negative regulation of cellular response to growth factor stimulus | 19 | 75 | 5.28e-03 |
| GO:BP | GO:0050767 | regulation of neurogenesis | 50 | 290 | 5.28e-03 |
| GO:BP | GO:0034762 | regulation of transmembrane transport | 51 | 298 | 5.43e-03 |
| GO:BP | GO:0071496 | cellular response to external stimulus | 47 | 268 | 5.43e-03 |
| GO:BP | GO:0043542 | endothelial cell migration | 34 | 174 | 5.43e-03 |
| GO:BP | GO:0010648 | negative regulation of cell communication | 141 | 1034 | 5.43e-03 |
| GO:BP | GO:0038084 | vascular endothelial growth factor signaling pathway | 12 | 36 | 5.43e-03 |
| GO:BP | GO:0040007 | growth | 101 | 697 | 5.54e-03 |
| GO:BP | GO:0010927 | cellular component assembly involved in morphogenesis | 24 | 107 | 5.74e-03 |
| GO:BP | GO:0098915 | membrane repolarization during ventricular cardiac muscle cell action potential | 6 | 10 | 5.82e-03 |
| GO:BP | GO:1902287 | semaphorin-plexin signaling pathway involved in axon guidance | 6 | 10 | 5.82e-03 |
| GO:BP | GO:0036363 | transforming growth factor beta activation | 6 | 10 | 5.82e-03 |
| GO:BP | GO:1902285 | semaphorin-plexin signaling pathway involved in neuron projection guidance | 6 | 10 | 5.82e-03 |
| GO:BP | GO:0045064 | T-helper 2 cell differentiation | 6 | 10 | 5.82e-03 |
| GO:BP | GO:0010634 | positive regulation of epithelial cell migration | 27 | 127 | 5.83e-03 |
| GO:BP | GO:0099625 | ventricular cardiac muscle cell membrane repolarization | 9 | 22 | 5.97e-03 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | 261 | 2100 | 6.08e-03 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | 51 | 300 | 6.08e-03 |
| GO:BP | GO:0044092 | negative regulation of molecular function | 77 | 504 | 6.28e-03 |
| GO:BP | GO:0030182 | neuron differentiation | 138 | 1014 | 6.61e-03 |
| GO:BP | GO:1990573 | potassium ion import across plasma membrane | 10 | 27 | 6.76e-03 |
| GO:BP | GO:0051173 | positive regulation of nitrogen compound metabolic process | 270 | 2186 | 6.85e-03 |
| GO:BP | GO:0048846 | axon extension involved in axon guidance | 11 | 32 | 6.94e-03 |
| GO:BP | GO:1902284 | neuron projection extension involved in neuron projection guidance | 11 | 32 | 6.94e-03 |
| GO:BP | GO:0098739 | import across plasma membrane | 26 | 122 | 7.02e-03 |
| GO:BP | GO:0010594 | regulation of endothelial cell migration | 28 | 136 | 7.51e-03 |
| GO:BP | GO:0031589 | cell-substrate adhesion | 45 | 258 | 7.63e-03 |
| GO:BP | GO:0086065 | cell communication involved in cardiac conduction | 15 | 54 | 7.78e-03 |
| GO:BP | GO:0006897 | endocytosis | 75 | 492 | 7.79e-03 |
| GO:BP | GO:0030510 | regulation of BMP signaling pathway | 19 | 78 | 8.05e-03 |
| GO:BP | GO:0070663 | regulation of leukocyte proliferation | 27 | 130 | 8.14e-03 |
| GO:BP | GO:0001817 | regulation of cytokine production | 68 | 437 | 8.20e-03 |
| GO:BP | GO:0030224 | monocyte differentiation | 9 | 23 | 8.26e-03 |
| GO:BP | GO:0002026 | regulation of the force of heart contraction | 9 | 23 | 8.26e-03 |
| GO:BP | GO:0045444 | fat cell differentiation | 34 | 179 | 8.34e-03 |
| GO:BP | GO:0048588 | developmental cell growth | 34 | 179 | 8.34e-03 |
| GO:BP | GO:0045668 | negative regulation of osteoblast differentiation | 12 | 38 | 8.48e-03 |
| GO:BP | GO:0050790 | regulation of catalytic activity | 123 | 893 | 8.49e-03 |
| GO:BP | GO:0044093 | positive regulation of molecular function | 110 | 783 | 8.49e-03 |
| GO:BP | GO:0042981 | regulation of apoptotic process | 139 | 1031 | 8.77e-03 |
| GO:BP | GO:0048841 | regulation of axon extension involved in axon guidance | 10 | 28 | 8.79e-03 |
| GO:BP | GO:0072659 | protein localization to plasma membrane | 42 | 238 | 8.82e-03 |
| GO:BP | GO:0031324 | negative regulation of cellular metabolic process | 241 | 1934 | 8.82e-03 |
| GO:BP | GO:0051336 | regulation of hydrolase activity | 67 | 431 | 8.90e-03 |
| GO:BP | GO:0055008 | cardiac muscle tissue morphogenesis | 15 | 55 | 9.02e-03 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | 132 | 972 | 9.02e-03 |
| GO:BP | GO:0042592 | homeostatic process | 151 | 1137 | 9.32e-03 |
| GO:BP | GO:0003151 | outflow tract morphogenesis | 17 | 67 | 9.32e-03 |
| GO:BP | GO:0060976 | coronary vasculature development | 13 | 44 | 9.36e-03 |
| GO:BP | GO:0086002 | cardiac muscle cell action potential involved in contraction | 13 | 44 | 9.36e-03 |
| GO:BP | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 48 | 284 | 9.36e-03 |
| GO:BP | GO:0050770 | regulation of axonogenesis | 26 | 125 | 9.36e-03 |
| GO:BP | GO:0043501 | skeletal muscle adaptation | 8 | 19 | 9.36e-03 |
| GO:BP | GO:0055010 | ventricular cardiac muscle tissue morphogenesis | 13 | 44 | 9.36e-03 |
| GO:BP | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 38 | 210 | 9.66e-03 |
| GO:BP | GO:0001816 | cytokine production | 68 | 441 | 9.72e-03 |
| GO:BP | GO:0014733 | regulation of skeletal muscle adaptation | 6 | 11 | 9.75e-03 |
| GO:BP | GO:1902307 | positive regulation of sodium ion transmembrane transport | 6 | 11 | 9.75e-03 |
| GO:BP | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 14 | 50 | 1.01e-02 |
| GO:BP | GO:0140747 | regulation of ncRNA transcription | 19 | 80 | 1.01e-02 |
| GO:BP | GO:0002828 | regulation of type 2 immune response | 7 | 15 | 1.02e-02 |
| GO:BP | GO:0051056 | regulation of small GTPase mediated signal transduction | 41 | 233 | 1.02e-02 |
| GO:BP | GO:0045785 | positive regulation of cell adhesion | 50 | 301 | 1.03e-02 |
| GO:BP | GO:0003229 | ventricular cardiac muscle tissue development | 15 | 56 | 1.04e-02 |
| GO:BP | GO:0046683 | response to organophosphorus | 21 | 93 | 1.04e-02 |
| GO:BP | GO:0003208 | cardiac ventricle morphogenesis | 16 | 62 | 1.06e-02 |
| GO:BP | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 9 | 24 | 1.06e-02 |
| GO:BP | GO:0010586 | miRNA metabolic process | 20 | 87 | 1.10e-02 |
| GO:BP | GO:0007009 | plasma membrane organization | 23 | 107 | 1.18e-02 |
| GO:BP | GO:0014896 | muscle hypertrophy | 18 | 75 | 1.21e-02 |
| GO:BP | GO:0002376 | immune system process | 181 | 1410 | 1.23e-02 |
| GO:BP | GO:0048638 | regulation of developmental growth | 42 | 243 | 1.24e-02 |
| GO:BP | GO:0002286 | T cell activation involved in immune response | 15 | 57 | 1.24e-02 |
| GO:BP | GO:0016049 | cell growth | 60 | 382 | 1.24e-02 |
| GO:BP | GO:0050873 | brown fat cell differentiation | 12 | 40 | 1.25e-02 |
| GO:BP | GO:0043067 | regulation of programmed cell death | 141 | 1060 | 1.25e-02 |
| GO:BP | GO:0071214 | cellular response to abiotic stimulus | 43 | 251 | 1.27e-02 |
| GO:BP | GO:0104004 | cellular response to environmental stimulus | 43 | 251 | 1.27e-02 |
| GO:BP | GO:2000651 | positive regulation of sodium ion transmembrane transporter activity | 5 | 8 | 1.30e-02 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | 44 | 259 | 1.31e-02 |
| GO:BP | GO:0006935 | chemotaxis | 42 | 244 | 1.31e-02 |
| GO:BP | GO:0043269 | regulation of monoatomic ion transport | 47 | 282 | 1.31e-02 |
| GO:BP | GO:0042330 | taxis | 42 | 244 | 1.31e-02 |
| GO:BP | GO:0006468 | protein phosphorylation | 129 | 958 | 1.31e-02 |
| GO:BP | GO:0035725 | sodium ion transmembrane transport | 21 | 95 | 1.32e-02 |
| GO:BP | GO:1901490 | regulation of lymphangiogenesis | 4 | 5 | 1.33e-02 |
| GO:BP | GO:0009987 | cellular process | 1129 | 10686 | 1.35e-02 |
| GO:BP | GO:0060485 | mesenchyme development | 42 | 245 | 1.38e-02 |
| GO:BP | GO:0099587 | inorganic ion import across plasma membrane | 17 | 70 | 1.38e-02 |
| GO:BP | GO:0071560 | cellular response to transforming growth factor beta stimulus | 38 | 215 | 1.38e-02 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | 119 | 874 | 1.38e-02 |
| GO:BP | GO:0098659 | inorganic cation import across plasma membrane | 17 | 70 | 1.38e-02 |
| GO:BP | GO:0003279 | cardiac septum development | 22 | 102 | 1.38e-02 |
| GO:BP | GO:0045321 | leukocyte activation | 78 | 530 | 1.39e-02 |
| GO:BP | GO:0030198 | extracellular matrix organization | 39 | 223 | 1.42e-02 |
| GO:BP | GO:0048858 | cell projection morphogenesis | 74 | 498 | 1.44e-02 |
| GO:BP | GO:0001843 | neural tube closure | 19 | 83 | 1.45e-02 |
| GO:BP | GO:0050670 | regulation of lymphocyte proliferation | 24 | 116 | 1.45e-02 |
| GO:BP | GO:0071375 | cellular response to peptide hormone stimulus | 40 | 231 | 1.47e-02 |
| GO:BP | GO:0045165 | cell fate commitment | 29 | 151 | 1.51e-02 |
| GO:BP | GO:0043062 | extracellular structure organization | 39 | 224 | 1.52e-02 |
| GO:BP | GO:0045229 | external encapsulating structure organization | 39 | 224 | 1.52e-02 |
| GO:BP | GO:0060419 | heart growth | 17 | 71 | 1.56e-02 |
| GO:BP | GO:0071407 | cellular response to organic cyclic compound | 59 | 379 | 1.56e-02 |
| GO:BP | GO:1903038 | negative regulation of leukocyte cell-cell adhesion | 17 | 71 | 1.56e-02 |
| GO:BP | GO:0090066 | regulation of anatomical structure size | 59 | 379 | 1.56e-02 |
| GO:BP | GO:2000146 | negative regulation of cell motility | 38 | 217 | 1.56e-02 |
| GO:BP | GO:0070664 | negative regulation of leukocyte proliferation | 13 | 47 | 1.56e-02 |
| GO:BP | GO:0048662 | negative regulation of smooth muscle cell proliferation | 11 | 36 | 1.61e-02 |
| GO:BP | GO:0055117 | regulation of cardiac muscle contraction | 16 | 65 | 1.61e-02 |
| GO:BP | GO:0035148 | tube formation | 25 | 124 | 1.62e-02 |
| GO:BP | GO:0061564 | axon development | 58 | 372 | 1.62e-02 |
| GO:BP | GO:0060606 | tube closure | 19 | 84 | 1.62e-02 |
| GO:BP | GO:0014912 | negative regulation of smooth muscle cell migration | 8 | 21 | 1.70e-02 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | 190 | 1504 | 1.71e-02 |
| GO:BP | GO:0120039 | plasma membrane bounded cell projection morphogenesis | 73 | 494 | 1.72e-02 |
| GO:BP | GO:0040008 | regulation of growth | 69 | 462 | 1.76e-02 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 191 | 1514 | 1.76e-02 |
| GO:BP | GO:0031333 | negative regulation of protein-containing complex assembly | 24 | 118 | 1.76e-02 |
| GO:BP | GO:0035051 | cardiocyte differentiation | 26 | 132 | 1.78e-02 |
| GO:BP | GO:0010721 | negative regulation of cell development | 33 | 182 | 1.78e-02 |
| GO:BP | GO:0071559 | response to transforming growth factor beta | 38 | 219 | 1.78e-02 |
| GO:BP | GO:0014812 | muscle cell migration | 17 | 72 | 1.78e-02 |
| GO:BP | GO:0002040 | sprouting angiogenesis | 21 | 98 | 1.79e-02 |
| GO:BP | GO:0001819 | positive regulation of cytokine production | 43 | 257 | 1.80e-02 |
| GO:BP | GO:0001570 | vasculogenesis | 16 | 66 | 1.83e-02 |
| GO:BP | GO:0035710 | CD4-positive, alpha-beta T cell activation | 16 | 66 | 1.83e-02 |
| GO:BP | GO:0051058 | negative regulation of small GTPase mediated signal transduction | 13 | 48 | 1.83e-02 |
| GO:BP | GO:0055007 | cardiac muscle cell differentiation | 22 | 105 | 1.84e-02 |
| GO:BP | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 14 | 54 | 1.85e-02 |
| GO:BP | GO:0046323 | glucose import | 14 | 54 | 1.85e-02 |
| GO:BP | GO:0060560 | developmental growth involved in morphogenesis | 34 | 190 | 1.85e-02 |
| GO:BP | GO:0032869 | cellular response to insulin stimulus | 30 | 161 | 1.86e-02 |
| GO:BP | GO:1902305 | regulation of sodium ion transmembrane transport | 11 | 37 | 1.93e-02 |
| GO:BP | GO:0021915 | neural tube development | 26 | 133 | 1.93e-02 |
| GO:BP | GO:0003300 | cardiac muscle hypertrophy | 17 | 73 | 2.00e-02 |
| GO:BP | GO:0030903 | notochord development | 7 | 17 | 2.00e-02 |
| GO:BP | GO:0010954 | positive regulation of protein processing | 7 | 17 | 2.00e-02 |
| GO:BP | GO:0010810 | regulation of cell-substrate adhesion | 30 | 162 | 2.03e-02 |
| GO:BP | GO:0042129 | regulation of T cell proliferation | 19 | 86 | 2.03e-02 |
| GO:BP | GO:0014070 | response to organic cyclic compound | 86 | 606 | 2.03e-02 |
| GO:BP | GO:0007409 | axonogenesis | 53 | 337 | 2.03e-02 |
| GO:BP | GO:0002293 | alpha-beta T cell differentiation involved in immune response | 12 | 43 | 2.04e-02 |
| GO:BP | GO:0002287 | alpha-beta T cell activation involved in immune response | 12 | 43 | 2.04e-02 |
| GO:BP | GO:0042093 | T-helper cell differentiation | 12 | 43 | 2.04e-02 |
| GO:BP | GO:0043086 | negative regulation of catalytic activity | 48 | 298 | 2.04e-02 |
| GO:BP | GO:0045214 | sarcomere organization | 12 | 43 | 2.04e-02 |
| GO:BP | GO:0002294 | CD4-positive, alpha-beta T cell differentiation involved in immune response | 12 | 43 | 2.04e-02 |
| GO:BP | GO:0060411 | cardiac septum morphogenesis | 16 | 67 | 2.04e-02 |
| GO:BP | GO:0071805 | potassium ion transmembrane transport | 24 | 120 | 2.06e-02 |
| GO:BP | GO:0043434 | response to peptide hormone | 50 | 314 | 2.07e-02 |
| GO:BP | GO:0035265 | organ growth | 25 | 127 | 2.07e-02 |
| GO:BP | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 5 | 9 | 2.12e-02 |
| GO:BP | GO:0007405 | neuroblast proliferation | 14 | 55 | 2.12e-02 |
| GO:BP | GO:1901388 | regulation of transforming growth factor beta activation | 5 | 9 | 2.12e-02 |
| GO:BP | GO:0032673 | regulation of interleukin-4 production | 6 | 13 | 2.19e-02 |
| GO:BP | GO:1903729 | regulation of plasma membrane organization | 6 | 13 | 2.19e-02 |
| GO:BP | GO:0032633 | interleukin-4 production | 6 | 13 | 2.19e-02 |
| GO:BP | GO:0048666 | neuron development | 113 | 838 | 2.21e-02 |
| GO:BP | GO:0014897 | striated muscle hypertrophy | 17 | 74 | 2.22e-02 |
| GO:BP | GO:0014020 | primary neural tube formation | 19 | 87 | 2.22e-02 |
| GO:BP | GO:0006811 | monoatomic ion transport | 99 | 719 | 2.24e-02 |
| GO:BP | GO:1901491 | negative regulation of lymphangiogenesis | 3 | 3 | 2.24e-02 |
| GO:BP | GO:0086047 | membrane depolarization during Purkinje myocyte cell action potential | 3 | 3 | 2.24e-02 |
| GO:BP | GO:0045760 | positive regulation of action potential | 3 | 3 | 2.24e-02 |
| GO:BP | GO:0007179 | transforming growth factor beta receptor signaling pathway | 31 | 171 | 2.24e-02 |
| GO:BP | GO:0006949 | syncytium formation | 11 | 38 | 2.25e-02 |
| GO:BP | GO:0043502 | regulation of muscle adaptation | 16 | 68 | 2.30e-02 |
| GO:BP | GO:0098771 | inorganic ion homeostasis | 54 | 348 | 2.32e-02 |
| GO:BP | GO:0001775 | cell activation | 88 | 627 | 2.32e-02 |
| GO:BP | GO:0032943 | mononuclear cell proliferation | 29 | 157 | 2.34e-02 |
| GO:BP | GO:0010959 | regulation of metal ion transport | 40 | 239 | 2.35e-02 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | 87 | 619 | 2.35e-02 |
| GO:BP | GO:0048878 | chemical homeostasis | 93 | 670 | 2.39e-02 |
| GO:BP | GO:0097485 | neuron projection guidance | 31 | 172 | 2.41e-02 |
| GO:BP | GO:0007411 | axon guidance | 31 | 172 | 2.41e-02 |
| GO:BP | GO:1903708 | positive regulation of hemopoiesis | 23 | 115 | 2.42e-02 |
| GO:BP | GO:1902107 | positive regulation of leukocyte differentiation | 23 | 115 | 2.42e-02 |
| GO:BP | GO:0098655 | monoatomic cation transmembrane transport | 72 | 495 | 2.42e-02 |
| GO:BP | GO:0061387 | regulation of extent of cell growth | 19 | 88 | 2.43e-02 |
| GO:BP | GO:0046631 | alpha-beta T cell activation | 19 | 88 | 2.43e-02 |
| GO:BP | GO:0150115 | cell-substrate junction organization | 20 | 95 | 2.54e-02 |
| GO:BP | GO:0030336 | negative regulation of cell migration | 36 | 210 | 2.54e-02 |
| GO:BP | GO:0098660 | inorganic ion transmembrane transport | 75 | 521 | 2.54e-02 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | 103 | 757 | 2.54e-02 |
| GO:BP | GO:0034765 | regulation of monoatomic ion transmembrane transport | 36 | 210 | 2.54e-02 |
| GO:BP | GO:1990778 | protein localization to cell periphery | 46 | 287 | 2.57e-02 |
| GO:BP | GO:0098662 | inorganic cation transmembrane transport | 70 | 480 | 2.57e-02 |
| GO:BP | GO:0003281 | ventricular septum development | 16 | 69 | 2.57e-02 |
| GO:BP | GO:0001508 | action potential | 21 | 102 | 2.57e-02 |
| GO:BP | GO:1903319 | positive regulation of protein maturation | 7 | 18 | 2.59e-02 |
| GO:BP | GO:0006814 | sodium ion transport | 26 | 137 | 2.60e-02 |
| GO:BP | GO:0032868 | response to insulin | 35 | 203 | 2.61e-02 |
| GO:BP | GO:0009266 | response to temperature stimulus | 23 | 116 | 2.62e-02 |
| GO:BP | GO:0006812 | monoatomic cation transport | 86 | 614 | 2.63e-02 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | 148 | 1150 | 2.63e-02 |
| GO:BP | GO:0003433 | chondrocyte development involved in endochondral bone morphogenesis | 4 | 6 | 2.66e-02 |
| GO:BP | GO:0048843 | negative regulation of axon extension involved in axon guidance | 8 | 23 | 2.67e-02 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | 237 | 1951 | 2.67e-02 |
| GO:BP | GO:0006950 | response to stress | 301 | 2540 | 2.67e-02 |
| GO:BP | GO:0010765 | positive regulation of sodium ion transport | 8 | 23 | 2.67e-02 |
| GO:BP | GO:0009612 | response to mechanical stimulus | 28 | 152 | 2.71e-02 |
| GO:BP | GO:0002573 | myeloid leukocyte differentiation | 28 | 152 | 2.71e-02 |
| GO:BP | GO:0002292 | T cell differentiation involved in immune response | 12 | 45 | 2.72e-02 |
| GO:BP | GO:0051346 | negative regulation of hydrolase activity | 23 | 117 | 2.87e-02 |
| GO:BP | GO:0072175 | epithelial tube formation | 23 | 117 | 2.87e-02 |
| GO:BP | GO:1903037 | regulation of leukocyte cell-cell adhesion | 34 | 197 | 2.88e-02 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | 89 | 642 | 2.90e-02 |
| GO:BP | GO:0009991 | response to extracellular stimulus | 57 | 377 | 2.90e-02 |
| GO:BP | GO:0016310 | phosphorylation | 147 | 1145 | 2.92e-02 |
| GO:BP | GO:0043114 | regulation of vascular permeability | 10 | 34 | 2.94e-02 |
| GO:BP | GO:0070661 | leukocyte proliferation | 31 | 175 | 2.94e-02 |
| GO:BP | GO:0050868 | negative regulation of T cell activation | 15 | 64 | 3.02e-02 |
| GO:BP | GO:0055017 | cardiac muscle tissue growth | 15 | 64 | 3.02e-02 |
| GO:BP | GO:0010885 | regulation of cholesterol storage | 6 | 14 | 3.03e-02 |
| GO:BP | GO:0050996 | positive regulation of lipid catabolic process | 6 | 14 | 3.03e-02 |
| GO:BP | GO:0031667 | response to nutrient levels | 54 | 354 | 3.06e-02 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | 32 | 183 | 3.06e-02 |
| GO:BP | GO:0046324 | regulation of glucose import | 11 | 40 | 3.11e-02 |
| GO:BP | GO:0071773 | cellular response to BMP stimulus | 23 | 118 | 3.11e-02 |
| GO:BP | GO:0002028 | regulation of sodium ion transport | 14 | 58 | 3.11e-02 |
| GO:BP | GO:0071772 | response to BMP | 23 | 118 | 3.11e-02 |
| GO:BP | GO:0002521 | leukocyte differentiation | 56 | 371 | 3.19e-02 |
| GO:BP | GO:0001501 | skeletal system development | 53 | 347 | 3.21e-02 |
| GO:BP | GO:0019222 | regulation of metabolic process | 518 | 4603 | 3.21e-02 |
| GO:BP | GO:0033275 | actin-myosin filament sliding | 5 | 10 | 3.22e-02 |
| GO:BP | GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis | 5 | 10 | 3.22e-02 |
| GO:BP | GO:0030948 | negative regulation of vascular endothelial growth factor receptor signaling pathway | 5 | 10 | 3.22e-02 |
| GO:BP | GO:0010832 | negative regulation of myotube differentiation | 5 | 10 | 3.22e-02 |
| GO:BP | GO:0007160 | cell-matrix adhesion | 30 | 169 | 3.22e-02 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | 218 | 1787 | 3.22e-02 |
| GO:BP | GO:0045926 | negative regulation of growth | 32 | 184 | 3.23e-02 |
| GO:BP | GO:0055085 | transmembrane transport | 121 | 921 | 3.23e-02 |
| GO:BP | GO:0050769 | positive regulation of neurogenesis | 32 | 184 | 3.23e-02 |
| GO:BP | GO:0034220 | monoatomic ion transmembrane transport | 82 | 587 | 3.31e-02 |
| GO:BP | GO:0060429 | epithelium development | 106 | 792 | 3.31e-02 |
| GO:BP | GO:0086010 | membrane depolarization during action potential | 8 | 24 | 3.31e-02 |
| GO:BP | GO:0060562 | epithelial tube morphogenesis | 42 | 261 | 3.31e-02 |
| GO:BP | GO:0014887 | cardiac muscle adaptation | 8 | 24 | 3.31e-02 |
| GO:BP | GO:0071398 | cellular response to fatty acid | 8 | 24 | 3.31e-02 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | 42 | 261 | 3.31e-02 |
| GO:BP | GO:0014898 | cardiac muscle hypertrophy in response to stress | 8 | 24 | 3.31e-02 |
| GO:BP | GO:0003299 | muscle hypertrophy in response to stress | 8 | 24 | 3.31e-02 |
| GO:BP | GO:0055006 | cardiac cell development | 17 | 78 | 3.33e-02 |
| GO:BP | GO:0048705 | skeletal system morphogenesis | 27 | 148 | 3.43e-02 |
| GO:BP | GO:0070228 | regulation of lymphocyte apoptotic process | 10 | 35 | 3.46e-02 |
| GO:BP | GO:0050994 | regulation of lipid catabolic process | 10 | 35 | 3.46e-02 |
| GO:BP | GO:0060840 | artery development | 18 | 85 | 3.47e-02 |
| GO:BP | GO:0048640 | negative regulation of developmental growth | 18 | 85 | 3.47e-02 |
| GO:BP | GO:0006816 | calcium ion transport | 42 | 262 | 3.51e-02 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | 228 | 1883 | 3.52e-02 |
| GO:BP | GO:0001657 | ureteric bud development | 16 | 72 | 3.53e-02 |
| GO:BP | GO:0022407 | regulation of cell-cell adhesion | 44 | 278 | 3.53e-02 |
| GO:BP | GO:0001841 | neural tube formation | 19 | 92 | 3.53e-02 |
| GO:BP | GO:0098609 | cell-cell adhesion | 79 | 564 | 3.53e-02 |
| GO:BP | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 19 | 92 | 3.53e-02 |
| GO:BP | GO:0055013 | cardiac muscle cell development | 16 | 72 | 3.53e-02 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | 44 | 278 | 3.53e-02 |
| GO:BP | GO:0001838 | embryonic epithelial tube formation | 21 | 106 | 3.62e-02 |
| GO:BP | GO:0030097 | hemopoiesis | 86 | 624 | 3.64e-02 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | 140 | 1093 | 3.68e-02 |
| GO:BP | GO:0002761 | regulation of myeloid leukocyte differentiation | 17 | 79 | 3.70e-02 |
| GO:BP | GO:0006793 | phosphorus metabolic process | 230 | 1904 | 3.70e-02 |
| GO:BP | GO:0018212 | peptidyl-tyrosine modification | 29 | 164 | 3.74e-02 |
| GO:BP | GO:0010647 | positive regulation of cell communication | 154 | 1218 | 3.75e-02 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | 50 | 327 | 3.80e-02 |
| GO:BP | GO:0014904 | myotube cell development | 9 | 30 | 3.80e-02 |
| GO:BP | GO:0006813 | potassium ion transport | 25 | 135 | 3.81e-02 |
| GO:BP | GO:0014909 | smooth muscle cell migration | 14 | 60 | 3.94e-02 |
| GO:BP | GO:0072164 | mesonephric tubule development | 16 | 73 | 3.97e-02 |
| GO:BP | GO:0072163 | mesonephric epithelium development | 16 | 73 | 3.97e-02 |
| GO:BP | GO:0007159 | leukocyte cell-cell adhesion | 36 | 218 | 4.06e-02 |
| GO:BP | GO:0023056 | positive regulation of signaling | 154 | 1221 | 4.07e-02 |
| GO:BP | GO:0071320 | cellular response to cAMP | 10 | 36 | 4.09e-02 |
| GO:BP | GO:0042475 | odontogenesis of dentin-containing tooth | 13 | 54 | 4.09e-02 |
| GO:BP | GO:0085029 | extracellular matrix assembly | 10 | 36 | 4.09e-02 |
| GO:BP | GO:0042130 | negative regulation of T cell proliferation | 10 | 36 | 4.09e-02 |
| GO:BP | GO:0002009 | morphogenesis of an epithelium | 55 | 369 | 4.10e-02 |
| GO:BP | GO:0007435 | salivary gland morphogenesis | 8 | 25 | 4.11e-02 |
| GO:BP | GO:0009410 | response to xenobiotic stimulus | 43 | 273 | 4.13e-02 |
| GO:BP | GO:1904062 | regulation of monoatomic cation transmembrane transport | 32 | 188 | 4.15e-02 |
| GO:BP | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 12 | 48 | 4.16e-02 |
| GO:BP | GO:0048667 | cell morphogenesis involved in neuron differentiation | 63 | 435 | 4.17e-02 |
| GO:BP | GO:0086009 | membrane repolarization | 11 | 42 | 4.17e-02 |
| GO:BP | GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 7 | 20 | 4.23e-02 |
| GO:BP | GO:0046651 | lymphocyte proliferation | 27 | 151 | 4.23e-02 |
| GO:BP | GO:1902547 | regulation of cellular response to vascular endothelial growth factor stimulus | 7 | 20 | 4.23e-02 |
| GO:BP | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 23 | 122 | 4.23e-02 |
| GO:BP | GO:0030308 | negative regulation of cell growth | 26 | 144 | 4.35e-02 |
| GO:BP | GO:0042391 | regulation of membrane potential | 44 | 282 | 4.37e-02 |
| GO:BP | GO:0001823 | mesonephros development | 16 | 74 | 4.41e-02 |
| GO:BP | GO:0010644 | cell communication by electrical coupling | 9 | 31 | 4.51e-02 |
| GO:BP | GO:0045657 | positive regulation of monocyte differentiation | 4 | 7 | 4.51e-02 |
| GO:BP | GO:0044351 | macropinocytosis | 4 | 7 | 4.51e-02 |
| GO:BP | GO:0042060 | wound healing | 45 | 291 | 4.51e-02 |
| GO:BP | GO:1900373 | positive regulation of purine nucleotide biosynthetic process | 4 | 7 | 4.51e-02 |
| GO:BP | GO:1903844 | regulation of cellular response to transforming growth factor beta stimulus | 23 | 123 | 4.51e-02 |
| GO:BP | GO:0010830 | regulation of myotube differentiation | 9 | 31 | 4.51e-02 |
| GO:BP | GO:1903351 | cellular response to dopamine | 9 | 31 | 4.51e-02 |
| GO:BP | GO:0002830 | positive regulation of type 2 immune response | 4 | 7 | 4.51e-02 |
| GO:BP | GO:0032753 | positive regulation of interleukin-4 production | 4 | 7 | 4.51e-02 |
| GO:BP | GO:0001558 | regulation of cell growth | 49 | 323 | 4.51e-02 |
| GO:BP | GO:0014883 | transition between fast and slow fiber | 4 | 7 | 4.51e-02 |
| GO:BP | GO:0048812 | neuron projection morphogenesis | 68 | 479 | 4.51e-02 |
| GO:BP | GO:0010975 | regulation of neuron projection development | 53 | 355 | 4.51e-02 |
| GO:BP | GO:0070296 | sarcoplasmic reticulum calcium ion transport | 9 | 31 | 4.51e-02 |
| GO:BP | GO:0045628 | regulation of T-helper 2 cell differentiation | 4 | 7 | 4.51e-02 |
| GO:BP | GO:0030810 | positive regulation of nucleotide biosynthetic process | 4 | 7 | 4.51e-02 |
| GO:BP | GO:0071634 | regulation of transforming growth factor beta production | 9 | 31 | 4.51e-02 |
| GO:BP | GO:0008150 | biological_process | 1175 | 11244 | 4.51e-02 |
| GO:BP | GO:0099622 | cardiac muscle cell membrane repolarization | 9 | 31 | 4.51e-02 |
| GO:BP | GO:0030030 | cell projection organization | 149 | 1182 | 4.51e-02 |
| GO:BP | GO:0090189 | regulation of branching involved in ureteric bud morphogenesis | 5 | 11 | 4.52e-02 |
| GO:BP | GO:0021783 | preganglionic parasympathetic fiber development | 5 | 11 | 4.52e-02 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | 18 | 88 | 4.53e-02 |
| GO:BP | GO:0031175 | neuron projection development | 99 | 743 | 4.54e-02 |
| GO:BP | GO:0150104 | transport across blood-brain barrier | 15 | 68 | 4.56e-02 |
| GO:BP | GO:0009894 | regulation of catabolic process | 109 | 830 | 4.56e-02 |
| GO:BP | GO:0010232 | vascular transport | 15 | 68 | 4.56e-02 |
| GO:BP | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 25 | 138 | 4.67e-02 |
| GO:BP | GO:0050672 | negative regulation of lymphocyte proliferation | 11 | 43 | 4.72e-02 |
| GO:BP | GO:0032945 | negative regulation of mononuclear cell proliferation | 11 | 43 | 4.72e-02 |
| GO:BP | GO:0051591 | response to cAMP | 14 | 62 | 4.90e-02 |
| GO:BP | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 8 | 26 | 4.94e-02 |
| GO:BP | GO:0007431 | salivary gland development | 8 | 26 | 4.94e-02 |
| GO:BP | GO:0086064 | cell communication by electrical coupling involved in cardiac conduction | 8 | 26 | 4.94e-02 |
| GO:BP | GO:0031323 | regulation of cellular metabolic process | 476 | 4233 | 4.98e-02 |
ESRnomtable_20k_enh %>%
filter(source=="KEGG", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in ESR enhancer neargenes_20k") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | 37 | 124 | 3.15e-07 |
| KEGG | KEGG:04022 | cGMP-PKG signaling pathway | 37 | 129 | 5.30e-07 |
| KEGG | KEGG:04925 | Aldosterone synthesis and secretion | 25 | 75 | 4.82e-06 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | 26 | 82 | 6.21e-06 |
| KEGG | KEGG:05200 | Pathways in cancer | 73 | 391 | 1.30e-05 |
| KEGG | KEGG:04024 | cAMP signaling pathway | 35 | 147 | 6.89e-05 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | 22 | 77 | 2.45e-04 |
| KEGG | KEGG:04976 | Bile secretion | 15 | 41 | 2.45e-04 |
| KEGG | KEGG:04931 | Insulin resistance | 24 | 91 | 3.33e-04 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | 27 | 113 | 6.15e-04 |
| KEGG | KEGG:04020 | Calcium signaling pathway | 34 | 161 | 7.81e-04 |
| KEGG | KEGG:04360 | Axon guidance | 33 | 155 | 7.81e-04 |
| KEGG | KEGG:04927 | Cortisol synthesis and secretion | 15 | 46 | 7.81e-04 |
| KEGG | KEGG:04725 | Cholinergic synapse | 21 | 82 | 1.14e-03 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | 24 | 100 | 1.14e-03 |
| KEGG | KEGG:05203 | Viral carcinogenesis | 30 | 142 | 1.66e-03 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | 33 | 164 | 1.93e-03 |
| KEGG | KEGG:04911 | Insulin secretion | 17 | 62 | 1.94e-03 |
| KEGG | KEGG:04971 | Gastric acid secretion | 15 | 51 | 1.95e-03 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 19 | 78 | 3.91e-03 |
| KEGG | KEGG:04934 | Cushing syndrome | 25 | 119 | 5.26e-03 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | 20 | 87 | 5.63e-03 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | 31 | 162 | 5.79e-03 |
| KEGG | KEGG:04260 | Cardiac muscle contraction | 16 | 63 | 5.98e-03 |
| KEGG | KEGG:04740 | Olfactory transduction | 9 | 25 | 6.49e-03 |
| KEGG | KEGG:04014 | Ras signaling pathway | 31 | 164 | 6.49e-03 |
| KEGG | KEGG:03320 | PPAR signaling pathway | 13 | 47 | 7.20e-03 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | 20 | 90 | 7.20e-03 |
| KEGG | KEGG:04371 | Apelin signaling pathway | 22 | 104 | 7.64e-03 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | 30 | 160 | 7.77e-03 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | 19 | 86 | 9.32e-03 |
| KEGG | KEGG:05030 | Cocaine addiction | 10 | 32 | 9.39e-03 |
| KEGG | KEGG:04713 | Circadian entrainment | 16 | 68 | 1.07e-02 |
| KEGG | KEGG:04520 | Adherens junction | 18 | 83 | 1.44e-02 |
| KEGG | KEGG:04728 | Dopaminergic synapse | 20 | 97 | 1.51e-02 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | 17 | 78 | 1.71e-02 |
| KEGG | KEGG:04923 | Regulation of lipolysis in adipocytes | 11 | 41 | 1.75e-02 |
| KEGG | KEGG:04814 | Motor proteins | 26 | 141 | 1.75e-02 |
| KEGG | KEGG:04380 | Osteoclast differentiation | 19 | 92 | 1.75e-02 |
| KEGG | KEGG:00000 | KEGG root term | 604 | 5451 | 1.96e-02 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | 40 | 250 | 2.10e-02 |
| KEGG | KEGG:04916 | Melanogenesis | 16 | 75 | 2.48e-02 |
| KEGG | KEGG:04913 | Ovarian steroidogenesis | 8 | 26 | 2.51e-02 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | 19 | 96 | 2.53e-02 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | 16 | 76 | 2.66e-02 |
| KEGG | KEGG:04310 | Wnt signaling pathway | 24 | 133 | 2.76e-02 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | 20 | 105 | 2.98e-02 |
| KEGG | KEGG:05031 | Amphetamine addiction | 11 | 45 | 3.12e-02 |
| KEGG | KEGG:04910 | Insulin signaling pathway | 21 | 113 | 3.13e-02 |
| KEGG | KEGG:04750 | Inflammatory mediator regulation of TRP channels | 15 | 72 | 3.48e-02 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | 25 | 144 | 3.51e-02 |
| KEGG | KEGG:04961 | Endocrine and other factor-regulated calcium reabsorption | 10 | 40 | 3.57e-02 |
| KEGG | KEGG:04659 | Th17 cell differentiation | 13 | 60 | 4.01e-02 |
| KEGG | KEGG:05034 | Alcoholism | 19 | 102 | 4.02e-02 |
| KEGG | KEGG:04510 | Focal adhesion | 28 | 169 | 4.02e-02 |
| KEGG | KEGG:04970 | Salivary secretion | 12 | 54 | 4.08e-02 |
| KEGG | KEGG:05032 | Morphine addiction | 12 | 54 | 4.08e-02 |
| KEGG | KEGG:05211 | Renal cell carcinoma | 13 | 62 | 4.79e-02 |
| KEGG | KEGG:05146 | Amoebiasis | 13 | 62 | 4.79e-02 |
| KEGG | KEGG:04721 | Synaptic vesicle cycle | 11 | 49 | 4.91e-02 |
LR 20,000 bp NG
# LR_resgenes_20k <- gost(query = LR_peak_list_20k$ENTREZID,
# organism = "hsapiens",
# significant = FALSE,
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = background_df$ENTREZID,
# sources=c("GO:BP","KEGG"))
# saveRDS(LR_resgenes_20k,"data/GO_KEGG_analysis/LR_resgenes_20k.RDS")
# LRnom <- gostplot(LR_resgenes_20k, capped = FALSE, interactive = TRUE)
# LRnom
LRnomtable_20k <- LR_resgenes_20k$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
LRnomtable_20k %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in LR nESRgenes_20k" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0032501 | multicellular organismal process | 3247 | 4504 | 2.82e-47 |
| GO:BP | GO:0048856 | anatomical structure development | 2795 | 3867 | 2.23e-39 |
| GO:BP | GO:0048731 | system development | 2022 | 2719 | 3.44e-38 |
| GO:BP | GO:0007275 | multicellular organism development | 2324 | 3170 | 7.17e-38 |
| GO:BP | GO:0032502 | developmental process | 2991 | 4179 | 1.92e-37 |
| GO:BP | GO:0007154 | cell communication | 2854 | 3983 | 1.21e-35 |
| GO:BP | GO:0023052 | signaling | 2810 | 3918 | 1.94e-35 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 1401 | 1844 | 6.31e-32 |
| GO:BP | GO:0007165 | signal transduction | 2587 | 3611 | 6.46e-31 |
| GO:BP | GO:0050896 | response to stimulus | 3737 | 5379 | 2.12e-30 |
| GO:BP | GO:0048869 | cellular developmental process | 2041 | 2804 | 6.29e-29 |
| GO:BP | GO:0030154 | cell differentiation | 2040 | 2803 | 6.90e-29 |
| GO:BP | GO:0051716 | cellular response to stimulus | 3243 | 4640 | 2.39e-27 |
| GO:BP | GO:0007399 | nervous system development | 1335 | 1775 | 8.03e-27 |
| GO:BP | GO:0022008 | neurogenesis | 963 | 1251 | 4.06e-24 |
| GO:BP | GO:0010646 | regulation of cell communication | 1772 | 2444 | 9.29e-23 |
| GO:BP | GO:0048699 | generation of neurons | 834 | 1076 | 3.77e-22 |
| GO:BP | GO:0023051 | regulation of signaling | 1765 | 2438 | 3.77e-22 |
| GO:BP | GO:0048513 | animal organ development | 1472 | 2004 | 4.86e-22 |
| GO:BP | GO:0050793 | regulation of developmental process | 1263 | 1697 | 5.10e-22 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 1416 | 1924 | 1.17e-21 |
| GO:BP | GO:0048468 | cell development | 1386 | 1886 | 1.13e-20 |
| GO:BP | GO:0030182 | neuron differentiation | 785 | 1014 | 1.66e-20 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | 1327 | 1801 | 2.11e-20 |
| GO:BP | GO:0050789 | regulation of biological process | 5035 | 7516 | 3.13e-20 |
| GO:BP | GO:0031175 | neuron projection development | 592 | 743 | 3.28e-20 |
| GO:BP | GO:0007155 | cell adhesion | 732 | 941 | 4.87e-20 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 1940 | 2717 | 5.30e-20 |
| GO:BP | GO:0048666 | neuron development | 656 | 838 | 5.56e-19 |
| GO:BP | GO:0000902 | cell morphogenesis | 567 | 713 | 5.79e-19 |
| GO:BP | GO:0065007 | biological regulation | 5159 | 7734 | 2.58e-18 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | 872 | 1150 | 2.65e-18 |
| GO:BP | GO:0030030 | cell projection organization | 894 | 1182 | 2.85e-18 |
| GO:BP | GO:0003008 | system process | 864 | 1139 | 3.17e-18 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | 475 | 588 | 3.28e-18 |
| GO:BP | GO:0050794 | regulation of cellular process | 4791 | 7153 | 6.38e-18 |
| GO:BP | GO:0009966 | regulation of signal transduction | 1557 | 2166 | 4.58e-17 |
| GO:BP | GO:0016477 | cell migration | 770 | 1011 | 7.96e-17 |
| GO:BP | GO:0048858 | cell projection morphogenesis | 406 | 498 | 9.87e-17 |
| GO:BP | GO:0048812 | neuron projection morphogenesis | 392 | 479 | 1.11e-16 |
| GO:BP | GO:0048518 | positive regulation of biological process | 2959 | 4301 | 1.11e-16 |
| GO:BP | GO:0120039 | plasma membrane bounded cell projection morphogenesis | 402 | 494 | 2.61e-16 |
| GO:BP | GO:0048870 | cell motility | 843 | 1120 | 3.51e-16 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 2728 | 3954 | 7.52e-16 |
| GO:BP | GO:0007267 | cell-cell signaling | 815 | 1082 | 9.81e-16 |
| GO:BP | GO:0048667 | cell morphogenesis involved in neuron differentiation | 357 | 435 | 1.66e-15 |
| GO:BP | GO:0065008 | regulation of biological quality | 1364 | 1893 | 3.54e-15 |
| GO:BP | GO:0009888 | tissue development | 993 | 1348 | 1.17e-14 |
| GO:BP | GO:0141124 | intracellular signaling cassette | 969 | 1314 | 1.78e-14 |
| GO:BP | GO:0034330 | cell junction organization | 433 | 545 | 3.80e-14 |
| GO:BP | GO:0051094 | positive regulation of developmental process | 691 | 913 | 6.65e-14 |
| GO:BP | GO:0040012 | regulation of locomotion | 556 | 720 | 8.00e-14 |
| GO:BP | GO:0120035 | regulation of plasma membrane bounded cell projection organization | 403 | 505 | 1.10e-13 |
| GO:BP | GO:0040011 | locomotion | 615 | 805 | 1.10e-13 |
| GO:BP | GO:0072359 | circulatory system development | 656 | 864 | 1.12e-13 |
| GO:BP | GO:0010975 | regulation of neuron projection development | 294 | 355 | 1.12e-13 |
| GO:BP | GO:2000145 | regulation of cell motility | 541 | 700 | 1.42e-13 |
| GO:BP | GO:0031344 | regulation of cell projection organization | 409 | 516 | 4.84e-13 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | 551 | 717 | 5.29e-13 |
| GO:BP | GO:0009887 | animal organ morphogenesis | 520 | 673 | 5.64e-13 |
| GO:BP | GO:0061564 | axon development | 304 | 372 | 1.22e-12 |
| GO:BP | GO:0001568 | blood vessel development | 414 | 525 | 1.43e-12 |
| GO:BP | GO:0030334 | regulation of cell migration | 515 | 668 | 1.53e-12 |
| GO:BP | GO:0007409 | axonogenesis | 278 | 337 | 1.71e-12 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | 473 | 609 | 2.07e-12 |
| GO:BP | GO:0045595 | regulation of cell differentiation | 794 | 1073 | 3.38e-12 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | 631 | 837 | 4.65e-12 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | 770 | 1040 | 7.02e-12 |
| GO:BP | GO:0098657 | import into cell | 480 | 622 | 9.09e-12 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | 708 | 951 | 1.15e-11 |
| GO:BP | GO:0035556 | intracellular signal transduction | 1383 | 1951 | 1.15e-11 |
| GO:BP | GO:0001944 | vasculature development | 430 | 552 | 1.40e-11 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 1323 | 1862 | 1.45e-11 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 764 | 1035 | 2.55e-11 |
| GO:BP | GO:0035295 | tube development | 593 | 787 | 3.20e-11 |
| GO:BP | GO:0003013 | circulatory system process | 339 | 426 | 3.72e-11 |
| GO:BP | GO:0098609 | cell-cell adhesion | 437 | 564 | 3.81e-11 |
| GO:BP | GO:0030029 | actin filament-based process | 490 | 640 | 4.81e-11 |
| GO:BP | GO:0044057 | regulation of system process | 308 | 384 | 7.16e-11 |
| GO:BP | GO:0051056 | regulation of small GTPase mediated signal transduction | 197 | 233 | 1.09e-10 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | 454 | 591 | 1.44e-10 |
| GO:BP | GO:0048519 | negative regulation of biological process | 2565 | 3764 | 1.53e-10 |
| GO:BP | GO:0006897 | endocytosis | 384 | 492 | 1.68e-10 |
| GO:BP | GO:0035239 | tube morphogenesis | 486 | 638 | 2.45e-10 |
| GO:BP | GO:0006810 | transport | 2054 | 2984 | 3.55e-10 |
| GO:BP | GO:0051093 | negative regulation of developmental process | 474 | 622 | 4.11e-10 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 868 | 1197 | 4.54e-10 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 2422 | 3550 | 4.64e-10 |
| GO:BP | GO:0032879 | regulation of localization | 1031 | 1439 | 4.65e-10 |
| GO:BP | GO:0016043 | cellular component organization | 3229 | 4802 | 7.98e-10 |
| GO:BP | GO:0051179 | localization | 2537 | 3731 | 9.27e-10 |
| GO:BP | GO:0051049 | regulation of transport | 798 | 1098 | 1.70e-09 |
| GO:BP | GO:0007264 | small GTPase-mediated signal transduction | 308 | 390 | 2.21e-09 |
| GO:BP | GO:0048589 | developmental growth | 386 | 501 | 3.35e-09 |
| GO:BP | GO:0030001 | metal ion transport | 402 | 524 | 3.65e-09 |
| GO:BP | GO:0009987 | cellular process | 6915 | 10686 | 5.43e-09 |
| GO:BP | GO:0048514 | blood vessel morphogenesis | 349 | 450 | 6.96e-09 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | 430 | 566 | 8.49e-09 |
| GO:BP | GO:0023056 | positive regulation of signaling | 877 | 1221 | 9.65e-09 |
| GO:BP | GO:0010647 | positive regulation of cell communication | 875 | 1218 | 9.65e-09 |
| GO:BP | GO:0042221 | response to chemical | 1596 | 2304 | 1.28e-08 |
| GO:BP | GO:0008015 | blood circulation | 282 | 357 | 1.41e-08 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | 624 | 850 | 2.01e-08 |
| GO:BP | GO:0030155 | regulation of cell adhesion | 388 | 508 | 2.12e-08 |
| GO:BP | GO:0008150 | biological_process | 7248 | 11244 | 2.12e-08 |
| GO:BP | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 351 | 456 | 3.01e-08 |
| GO:BP | GO:0051234 | establishment of localization | 2205 | 3240 | 3.03e-08 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | 1062 | 1504 | 5.39e-08 |
| GO:BP | GO:0007010 | cytoskeleton organization | 822 | 1146 | 5.91e-08 |
| GO:BP | GO:0097435 | supramolecular fiber organization | 473 | 633 | 5.91e-08 |
| GO:BP | GO:0071417 | cellular response to organonitrogen compound | 340 | 442 | 6.37e-08 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | 347 | 452 | 6.39e-08 |
| GO:BP | GO:0002062 | chondrocyte differentiation | 81 | 88 | 7.39e-08 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | 1225 | 1751 | 7.72e-08 |
| GO:BP | GO:0034329 | cell junction assembly | 255 | 323 | 1.10e-07 |
| GO:BP | GO:0016192 | vesicle-mediated transport | 824 | 1152 | 1.30e-07 |
| GO:BP | GO:0007417 | central nervous system development | 513 | 694 | 1.59e-07 |
| GO:BP | GO:0099537 | trans-synaptic signaling | 356 | 467 | 1.62e-07 |
| GO:BP | GO:0099536 | synaptic signaling | 367 | 483 | 1.79e-07 |
| GO:BP | GO:0034220 | monoatomic ion transmembrane transport | 439 | 587 | 1.92e-07 |
| GO:BP | GO:0099177 | regulation of trans-synaptic signaling | 254 | 323 | 2.29e-07 |
| GO:BP | GO:0006811 | monoatomic ion transport | 529 | 719 | 2.71e-07 |
| GO:BP | GO:0050804 | modulation of chemical synaptic transmission | 253 | 322 | 2.81e-07 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | 782 | 1093 | 3.16e-07 |
| GO:BP | GO:0007268 | chemical synaptic transmission | 352 | 463 | 3.27e-07 |
| GO:BP | GO:0098916 | anterograde trans-synaptic signaling | 352 | 463 | 3.27e-07 |
| GO:BP | GO:0098660 | inorganic ion transmembrane transport | 392 | 521 | 3.95e-07 |
| GO:BP | GO:0016310 | phosphorylation | 816 | 1145 | 4.44e-07 |
| GO:BP | GO:0051960 | regulation of nervous system development | 264 | 339 | 5.96e-07 |
| GO:BP | GO:0071310 | cellular response to organic substance | 916 | 1297 | 8.30e-07 |
| GO:BP | GO:0042391 | regulation of membrane potential | 223 | 282 | 8.39e-07 |
| GO:BP | GO:2000147 | positive regulation of cell motility | 312 | 408 | 8.56e-07 |
| GO:BP | GO:0050770 | regulation of axonogenesis | 108 | 125 | 8.81e-07 |
| GO:BP | GO:0050808 | synapse organization | 262 | 337 | 8.81e-07 |
| GO:BP | GO:0001501 | skeletal system development | 269 | 347 | 9.14e-07 |
| GO:BP | GO:0001503 | ossification | 237 | 302 | 9.90e-07 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | 910 | 1289 | 1.00e-06 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | 361 | 479 | 1.10e-06 |
| GO:BP | GO:0070848 | response to growth factor | 408 | 547 | 1.11e-06 |
| GO:BP | GO:0006812 | monoatomic cation transport | 454 | 614 | 1.15e-06 |
| GO:BP | GO:0040017 | positive regulation of locomotion | 317 | 416 | 1.18e-06 |
| GO:BP | GO:0061448 | connective tissue development | 167 | 205 | 1.18e-06 |
| GO:BP | GO:0061061 | muscle structure development | 400 | 536 | 1.36e-06 |
| GO:BP | GO:0030335 | positive regulation of cell migration | 302 | 395 | 1.41e-06 |
| GO:BP | GO:0031346 | positive regulation of cell projection organization | 225 | 286 | 1.49e-06 |
| GO:BP | GO:0030900 | forebrain development | 215 | 272 | 1.49e-06 |
| GO:BP | GO:0001525 | angiogenesis | 292 | 381 | 1.57e-06 |
| GO:BP | GO:0060627 | regulation of vesicle-mediated transport | 287 | 374 | 1.66e-06 |
| GO:BP | GO:0007507 | heart development | 374 | 499 | 1.68e-06 |
| GO:BP | GO:0006468 | protein phosphorylation | 686 | 958 | 2.16e-06 |
| GO:BP | GO:0048771 | tissue remodeling | 98 | 113 | 2.51e-06 |
| GO:BP | GO:0098662 | inorganic cation transmembrane transport | 360 | 480 | 2.67e-06 |
| GO:BP | GO:0051216 | cartilage development | 122 | 145 | 2.67e-06 |
| GO:BP | GO:0050767 | regulation of neurogenesis | 227 | 290 | 2.67e-06 |
| GO:BP | GO:1903522 | regulation of blood circulation | 158 | 194 | 2.75e-06 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 3312 | 4988 | 2.76e-06 |
| GO:BP | GO:0031589 | cell-substrate adhesion | 204 | 258 | 3.07e-06 |
| GO:BP | GO:0044089 | positive regulation of cellular component biogenesis | 297 | 390 | 3.39e-06 |
| GO:BP | GO:0048638 | regulation of developmental growth | 193 | 243 | 3.74e-06 |
| GO:BP | GO:0060322 | head development | 400 | 539 | 3.74e-06 |
| GO:BP | GO:0043087 | regulation of GTPase activity | 137 | 166 | 4.43e-06 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | 392 | 528 | 4.66e-06 |
| GO:BP | GO:0016055 | Wnt signaling pathway | 274 | 358 | 4.90e-06 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | 548 | 757 | 5.19e-06 |
| GO:BP | GO:0098655 | monoatomic cation transmembrane transport | 369 | 495 | 5.31e-06 |
| GO:BP | GO:0010243 | response to organonitrogen compound | 499 | 685 | 5.42e-06 |
| GO:BP | GO:0007015 | actin filament organization | 273 | 357 | 5.82e-06 |
| GO:BP | GO:0051241 | negative regulation of multicellular organismal process | 513 | 706 | 6.07e-06 |
| GO:BP | GO:0097485 | neuron projection guidance | 141 | 172 | 6.24e-06 |
| GO:BP | GO:0007411 | axon guidance | 141 | 172 | 6.24e-06 |
| GO:BP | GO:0060047 | heart contraction | 157 | 194 | 6.32e-06 |
| GO:BP | GO:0198738 | cell-cell signaling by wnt | 274 | 359 | 7.32e-06 |
| GO:BP | GO:0003015 | heart process | 164 | 204 | 7.73e-06 |
| GO:BP | GO:0034762 | regulation of transmembrane transport | 231 | 298 | 7.99e-06 |
| GO:BP | GO:0003012 | muscle system process | 250 | 325 | 8.03e-06 |
| GO:BP | GO:0140352 | export from cell | 436 | 594 | 8.12e-06 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | 839 | 1193 | 9.34e-06 |
| GO:BP | GO:0044093 | positive regulation of molecular function | 564 | 783 | 9.57e-06 |
| GO:BP | GO:0060429 | epithelium development | 570 | 792 | 9.84e-06 |
| GO:BP | GO:0030010 | establishment of cell polarity | 105 | 124 | 1.05e-05 |
| GO:BP | GO:0014706 | striated muscle tissue development | 170 | 213 | 1.12e-05 |
| GO:BP | GO:0009790 | embryo development | 589 | 821 | 1.23e-05 |
| GO:BP | GO:0006793 | phosphorus metabolic process | 1308 | 1904 | 1.24e-05 |
| GO:BP | GO:0010720 | positive regulation of cell development | 238 | 309 | 1.27e-05 |
| GO:BP | GO:0046903 | secretion | 454 | 622 | 1.31e-05 |
| GO:BP | GO:0008016 | regulation of heart contraction | 135 | 165 | 1.34e-05 |
| GO:BP | GO:0035265 | organ growth | 107 | 127 | 1.34e-05 |
| GO:BP | GO:0030111 | regulation of Wnt signaling pathway | 204 | 261 | 1.34e-05 |
| GO:BP | GO:0048639 | positive regulation of developmental growth | 101 | 119 | 1.36e-05 |
| GO:BP | GO:0048729 | tissue morphogenesis | 338 | 453 | 1.41e-05 |
| GO:BP | GO:1901698 | response to nitrogen compound | 531 | 736 | 1.50e-05 |
| GO:BP | GO:0060284 | regulation of cell development | 418 | 570 | 1.64e-05 |
| GO:BP | GO:0040007 | growth | 504 | 697 | 1.93e-05 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | 770 | 1093 | 1.93e-05 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | 1292 | 1883 | 2.12e-05 |
| GO:BP | GO:0090066 | regulation of anatomical structure size | 286 | 379 | 2.12e-05 |
| GO:BP | GO:0045229 | external encapsulating structure organization | 177 | 224 | 2.12e-05 |
| GO:BP | GO:0043062 | extracellular structure organization | 177 | 224 | 2.12e-05 |
| GO:BP | GO:0032409 | regulation of transporter activity | 122 | 148 | 2.19e-05 |
| GO:BP | GO:0007420 | brain development | 368 | 498 | 2.25e-05 |
| GO:BP | GO:0090257 | regulation of muscle system process | 143 | 177 | 2.47e-05 |
| GO:BP | GO:0031032 | actomyosin structure organization | 148 | 184 | 2.56e-05 |
| GO:BP | GO:0030198 | extracellular matrix organization | 176 | 223 | 2.56e-05 |
| GO:BP | GO:1901652 | response to peptide | 278 | 368 | 2.56e-05 |
| GO:BP | GO:0023057 | negative regulation of signaling | 731 | 1036 | 2.56e-05 |
| GO:BP | GO:0050877 | nervous system process | 437 | 600 | 3.04e-05 |
| GO:BP | GO:0022898 | regulation of transmembrane transporter activity | 115 | 139 | 3.12e-05 |
| GO:BP | GO:0016358 | dendrite development | 147 | 183 | 3.23e-05 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | 230 | 300 | 3.47e-05 |
| GO:BP | GO:1901653 | cellular response to peptide | 211 | 273 | 3.50e-05 |
| GO:BP | GO:0048588 | developmental cell growth | 144 | 179 | 3.51e-05 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | 569 | 796 | 3.79e-05 |
| GO:BP | GO:0010033 | response to organic substance | 1193 | 1736 | 3.81e-05 |
| GO:BP | GO:0150115 | cell-substrate junction organization | 82 | 95 | 3.82e-05 |
| GO:BP | GO:0006816 | calcium ion transport | 203 | 262 | 4.05e-05 |
| GO:BP | GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 111 | 134 | 4.17e-05 |
| GO:BP | GO:0043269 | regulation of monoatomic ion transport | 217 | 282 | 4.26e-05 |
| GO:BP | GO:0010648 | negative regulation of cell communication | 728 | 1034 | 4.32e-05 |
| GO:BP | GO:0050772 | positive regulation of axonogenesis | 58 | 64 | 4.56e-05 |
| GO:BP | GO:0007423 | sensory organ development | 290 | 387 | 4.70e-05 |
| GO:BP | GO:0072001 | renal system development | 190 | 244 | 4.80e-05 |
| GO:BP | GO:0055085 | transmembrane transport | 652 | 921 | 5.07e-05 |
| GO:BP | GO:1990778 | protein localization to cell periphery | 220 | 287 | 5.83e-05 |
| GO:BP | GO:0065009 | regulation of molecular function | 903 | 1299 | 5.98e-05 |
| GO:BP | GO:0032940 | secretion by cell | 402 | 551 | 5.98e-05 |
| GO:BP | GO:0043547 | positive regulation of GTPase activity | 95 | 113 | 6.60e-05 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | 1769 | 2622 | 7.36e-05 |
| GO:BP | GO:0070588 | calcium ion transmembrane transport | 165 | 210 | 8.86e-05 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | 76 | 88 | 8.86e-05 |
| GO:BP | GO:0030100 | regulation of endocytosis | 155 | 196 | 8.93e-05 |
| GO:BP | GO:0018212 | peptidyl-tyrosine modification | 132 | 164 | 8.96e-05 |
| GO:BP | GO:0001667 | ameboidal-type cell migration | 259 | 344 | 8.96e-05 |
| GO:BP | GO:0007186 | G protein-coupled receptor signaling pathway | 288 | 386 | 9.24e-05 |
| GO:BP | GO:0009605 | response to external stimulus | 1073 | 1559 | 9.26e-05 |
| GO:BP | GO:0045785 | positive regulation of cell adhesion | 229 | 301 | 9.26e-05 |
| GO:BP | GO:0042592 | homeostatic process | 794 | 1137 | 9.38e-05 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | 684 | 972 | 9.94e-05 |
| GO:BP | GO:1901888 | regulation of cell junction assembly | 126 | 156 | 1.05e-04 |
| GO:BP | GO:0032535 | regulation of cellular component size | 219 | 287 | 1.05e-04 |
| GO:BP | GO:0045216 | cell-cell junction organization | 123 | 152 | 1.14e-04 |
| GO:BP | GO:0030048 | actin filament-based movement | 90 | 107 | 1.14e-04 |
| GO:BP | GO:0001654 | eye development | 202 | 263 | 1.16e-04 |
| GO:BP | GO:0048880 | sensory system development | 204 | 266 | 1.23e-04 |
| GO:BP | GO:0051641 | cellular localization | 1767 | 2623 | 1.23e-04 |
| GO:BP | GO:0048705 | skeletal system morphogenesis | 120 | 148 | 1.23e-04 |
| GO:BP | GO:0048871 | multicellular organismal-level homeostasis | 390 | 536 | 1.25e-04 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | 158 | 201 | 1.30e-04 |
| GO:BP | GO:0048598 | embryonic morphogenesis | 312 | 422 | 1.32e-04 |
| GO:BP | GO:0060070 | canonical Wnt signaling pathway | 187 | 242 | 1.32e-04 |
| GO:BP | GO:0018108 | peptidyl-tyrosine phosphorylation | 130 | 162 | 1.35e-04 |
| GO:BP | GO:0035023 | regulation of Rho protein signal transduction | 58 | 65 | 1.40e-04 |
| GO:BP | GO:0060560 | developmental growth involved in morphogenesis | 150 | 190 | 1.44e-04 |
| GO:BP | GO:0071375 | cellular response to peptide hormone stimulus | 179 | 231 | 1.54e-04 |
| GO:BP | GO:0043434 | response to peptide hormone | 237 | 314 | 1.64e-04 |
| GO:BP | GO:0034765 | regulation of monoatomic ion transmembrane transport | 164 | 210 | 1.70e-04 |
| GO:BP | GO:0042330 | taxis | 188 | 244 | 1.70e-04 |
| GO:BP | GO:0006935 | chemotaxis | 188 | 244 | 1.70e-04 |
| GO:BP | GO:0150063 | visual system development | 202 | 264 | 1.74e-04 |
| GO:BP | GO:0032101 | regulation of response to external stimulus | 469 | 654 | 1.76e-04 |
| GO:BP | GO:0001822 | kidney development | 183 | 237 | 1.76e-04 |
| GO:BP | GO:0048167 | regulation of synaptic plasticity | 113 | 139 | 1.77e-04 |
| GO:BP | GO:0043010 | camera-type eye development | 178 | 230 | 1.83e-04 |
| GO:BP | GO:0061337 | cardiac conduction | 73 | 85 | 1.96e-04 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | 641 | 911 | 1.98e-04 |
| GO:BP | GO:0071559 | response to transforming growth factor beta | 170 | 219 | 2.14e-04 |
| GO:BP | GO:0071560 | cellular response to transforming growth factor beta stimulus | 167 | 215 | 2.41e-04 |
| GO:BP | GO:1990138 | neuron projection extension | 109 | 134 | 2.43e-04 |
| GO:BP | GO:0003018 | vascular process in circulatory system | 152 | 194 | 2.61e-04 |
| GO:BP | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 78 | 92 | 2.61e-04 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | 318 | 433 | 2.63e-04 |
| GO:BP | GO:0009725 | response to hormone | 438 | 610 | 2.89e-04 |
| GO:BP | GO:0007160 | cell-matrix adhesion | 134 | 169 | 2.95e-04 |
| GO:BP | GO:0045165 | cell fate commitment | 121 | 151 | 3.13e-04 |
| GO:BP | GO:0010976 | positive regulation of neuron projection development | 105 | 129 | 3.32e-04 |
| GO:BP | GO:0001764 | neuron migration | 105 | 129 | 3.32e-04 |
| GO:BP | GO:0060828 | regulation of canonical Wnt signaling pathway | 158 | 203 | 3.37e-04 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | 397 | 550 | 3.39e-04 |
| GO:BP | GO:0006898 | receptor-mediated endocytosis | 143 | 182 | 3.60e-04 |
| GO:BP | GO:0035108 | limb morphogenesis | 91 | 110 | 3.63e-04 |
| GO:BP | GO:0035107 | appendage morphogenesis | 91 | 110 | 3.63e-04 |
| GO:BP | GO:0040013 | negative regulation of locomotion | 186 | 243 | 3.70e-04 |
| GO:BP | GO:0061572 | actin filament bundle organization | 107 | 132 | 3.83e-04 |
| GO:BP | GO:0010959 | regulation of metal ion transport | 183 | 239 | 4.18e-04 |
| GO:BP | GO:0021537 | telencephalon development | 152 | 195 | 4.19e-04 |
| GO:BP | GO:0060348 | bone development | 117 | 146 | 4.23e-04 |
| GO:BP | GO:1904062 | regulation of monoatomic cation transmembrane transport | 147 | 188 | 4.27e-04 |
| GO:BP | GO:0007610 | behavior | 308 | 420 | 4.27e-04 |
| GO:BP | GO:0001952 | regulation of cell-matrix adhesion | 76 | 90 | 4.40e-04 |
| GO:BP | GO:0007266 | Rho protein signal transduction | 90 | 109 | 4.62e-04 |
| GO:BP | GO:0051017 | actin filament bundle assembly | 106 | 131 | 4.80e-04 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | 337 | 463 | 4.89e-04 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | 337 | 463 | 4.89e-04 |
| GO:BP | GO:0072659 | protein localization to plasma membrane | 182 | 238 | 4.92e-04 |
| GO:BP | GO:0060537 | muscle tissue development | 252 | 339 | 5.20e-04 |
| GO:BP | GO:0043085 | positive regulation of catalytic activity | 393 | 546 | 5.51e-04 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 1624 | 2415 | 5.60e-04 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | 399 | 555 | 5.66e-04 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | 143 | 183 | 5.75e-04 |
| GO:BP | GO:0048041 | focal adhesion assembly | 66 | 77 | 5.84e-04 |
| GO:BP | GO:0010810 | regulation of cell-substrate adhesion | 128 | 162 | 5.96e-04 |
| GO:BP | GO:0022604 | regulation of cell morphogenesis | 150 | 193 | 6.05e-04 |
| GO:BP | GO:0038127 | ERBB signaling pathway | 86 | 104 | 6.18e-04 |
| GO:BP | GO:0021955 | central nervous system neuron axonogenesis | 30 | 31 | 6.27e-04 |
| GO:BP | GO:0002009 | morphogenesis of an epithelium | 272 | 369 | 6.93e-04 |
| GO:BP | GO:0008361 | regulation of cell size | 117 | 147 | 7.27e-04 |
| GO:BP | GO:0050900 | leukocyte migration | 151 | 195 | 7.99e-04 |
| GO:BP | GO:0042327 | positive regulation of phosphorylation | 303 | 415 | 8.53e-04 |
| GO:BP | GO:0046849 | bone remodeling | 52 | 59 | 8.81e-04 |
| GO:BP | GO:0001649 | osteoblast differentiation | 136 | 174 | 8.81e-04 |
| GO:BP | GO:0035725 | sodium ion transmembrane transport | 79 | 95 | 8.92e-04 |
| GO:BP | GO:0043408 | regulation of MAPK cascade | 311 | 427 | 9.14e-04 |
| GO:BP | GO:0008360 | regulation of cell shape | 87 | 106 | 9.57e-04 |
| GO:BP | GO:0110020 | regulation of actomyosin structure organization | 73 | 87 | 9.68e-04 |
| GO:BP | GO:0001775 | cell activation | 446 | 627 | 9.73e-04 |
| GO:BP | GO:0090130 | tissue migration | 187 | 247 | 1.03e-03 |
| GO:BP | GO:0050807 | regulation of synapse organization | 135 | 173 | 1.07e-03 |
| GO:BP | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 120 | 152 | 1.12e-03 |
| GO:BP | GO:0090132 | epithelium migration | 184 | 243 | 1.16e-03 |
| GO:BP | GO:0010631 | epithelial cell migration | 184 | 243 | 1.16e-03 |
| GO:BP | GO:0051494 | negative regulation of cytoskeleton organization | 102 | 127 | 1.17e-03 |
| GO:BP | GO:0002063 | chondrocyte development | 23 | 23 | 1.19e-03 |
| GO:BP | GO:0051336 | regulation of hydrolase activity | 313 | 431 | 1.23e-03 |
| GO:BP | GO:0007229 | integrin-mediated signaling pathway | 72 | 86 | 1.25e-03 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | 226 | 304 | 1.31e-03 |
| GO:BP | GO:0006814 | sodium ion transport | 109 | 137 | 1.36e-03 |
| GO:BP | GO:0006936 | muscle contraction | 192 | 255 | 1.39e-03 |
| GO:BP | GO:0051962 | positive regulation of nervous system development | 162 | 212 | 1.42e-03 |
| GO:BP | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 212 | 284 | 1.44e-03 |
| GO:BP | GO:0000165 | MAPK cascade | 362 | 504 | 1.46e-03 |
| GO:BP | GO:0021987 | cerebral cortex development | 77 | 93 | 1.46e-03 |
| GO:BP | GO:0034103 | regulation of tissue remodeling | 40 | 44 | 1.46e-03 |
| GO:BP | GO:0008283 | cell population proliferation | 895 | 1306 | 1.46e-03 |
| GO:BP | GO:0051173 | positive regulation of nitrogen compound metabolic process | 1470 | 2186 | 1.47e-03 |
| GO:BP | GO:0050920 | regulation of chemotaxis | 106 | 133 | 1.47e-03 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | 196 | 261 | 1.49e-03 |
| GO:BP | GO:0031623 | receptor internalization | 74 | 89 | 1.52e-03 |
| GO:BP | GO:0051050 | positive regulation of transport | 407 | 571 | 1.52e-03 |
| GO:BP | GO:0009611 | response to wounding | 279 | 382 | 1.56e-03 |
| GO:BP | GO:0021954 | central nervous system neuron development | 50 | 57 | 1.56e-03 |
| GO:BP | GO:0032231 | regulation of actin filament bundle assembly | 71 | 85 | 1.58e-03 |
| GO:BP | GO:0050769 | positive regulation of neurogenesis | 142 | 184 | 1.71e-03 |
| GO:BP | GO:0048592 | eye morphogenesis | 87 | 107 | 1.76e-03 |
| GO:BP | GO:2000146 | negative regulation of cell motility | 165 | 217 | 1.86e-03 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | 194 | 259 | 2.06e-03 |
| GO:BP | GO:0050803 | regulation of synapse structure or activity | 136 | 176 | 2.19e-03 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | 52 | 60 | 2.23e-03 |
| GO:BP | GO:0006835 | dicarboxylic acid transport | 52 | 60 | 2.23e-03 |
| GO:BP | GO:0150116 | regulation of cell-substrate junction organization | 52 | 60 | 2.23e-03 |
| GO:BP | GO:0098900 | regulation of action potential | 35 | 38 | 2.23e-03 |
| GO:BP | GO:0031345 | negative regulation of cell projection organization | 114 | 145 | 2.24e-03 |
| GO:BP | GO:0010232 | vascular transport | 58 | 68 | 2.27e-03 |
| GO:BP | GO:0043502 | regulation of muscle adaptation | 58 | 68 | 2.27e-03 |
| GO:BP | GO:0150104 | transport across blood-brain barrier | 58 | 68 | 2.27e-03 |
| GO:BP | GO:0043149 | stress fiber assembly | 75 | 91 | 2.33e-03 |
| GO:BP | GO:0030038 | contractile actin filament bundle assembly | 75 | 91 | 2.33e-03 |
| GO:BP | GO:0070252 | actin-mediated cell contraction | 72 | 87 | 2.49e-03 |
| GO:BP | GO:0010977 | negative regulation of neuron projection development | 88 | 109 | 2.55e-03 |
| GO:BP | GO:0071695 | anatomical structure maturation | 118 | 151 | 2.67e-03 |
| GO:BP | GO:0003205 | cardiac chamber development | 118 | 151 | 2.67e-03 |
| GO:BP | GO:0003007 | heart morphogenesis | 165 | 218 | 2.72e-03 |
| GO:BP | GO:0048259 | regulation of receptor-mediated endocytosis | 66 | 79 | 2.74e-03 |
| GO:BP | GO:0030278 | regulation of ossification | 66 | 79 | 2.74e-03 |
| GO:BP | GO:0051893 | regulation of focal adhesion assembly | 48 | 55 | 2.80e-03 |
| GO:BP | GO:0051057 | positive regulation of small GTPase mediated signal transduction | 48 | 55 | 2.80e-03 |
| GO:BP | GO:0090109 | regulation of cell-substrate junction assembly | 48 | 55 | 2.80e-03 |
| GO:BP | GO:0098901 | regulation of cardiac muscle cell action potential | 26 | 27 | 2.81e-03 |
| GO:BP | GO:0001934 | positive regulation of protein phosphorylation | 287 | 396 | 2.91e-03 |
| GO:BP | GO:0086001 | cardiac muscle cell action potential | 54 | 63 | 2.96e-03 |
| GO:BP | GO:0061351 | neural precursor cell proliferation | 95 | 119 | 2.96e-03 |
| GO:BP | GO:0051345 | positive regulation of hydrolase activity | 198 | 266 | 3.05e-03 |
| GO:BP | GO:1902305 | regulation of sodium ion transmembrane transport | 34 | 37 | 3.06e-03 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | 561 | 805 | 3.08e-03 |
| GO:BP | GO:0042692 | muscle cell differentiation | 237 | 323 | 3.24e-03 |
| GO:BP | GO:0097553 | calcium ion transmembrane import into cytosol | 97 | 122 | 3.32e-03 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | 560 | 804 | 3.39e-03 |
| GO:BP | GO:0030336 | negative regulation of cell migration | 159 | 210 | 3.40e-03 |
| GO:BP | GO:0048762 | mesenchymal cell differentiation | 152 | 200 | 3.45e-03 |
| GO:BP | GO:0048008 | platelet-derived growth factor receptor signaling pathway | 44 | 50 | 3.50e-03 |
| GO:BP | GO:0050890 | cognition | 161 | 213 | 3.55e-03 |
| GO:BP | GO:0014897 | striated muscle hypertrophy | 62 | 74 | 3.63e-03 |
| GO:BP | GO:1902904 | negative regulation of supramolecular fiber organization | 99 | 125 | 3.68e-03 |
| GO:BP | GO:0002028 | regulation of sodium ion transport | 50 | 58 | 3.84e-03 |
| GO:BP | GO:0060485 | mesenchyme development | 183 | 245 | 3.90e-03 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | 297 | 412 | 4.02e-03 |
| GO:BP | GO:0030178 | negative regulation of Wnt signaling pathway | 106 | 135 | 4.03e-03 |
| GO:BP | GO:0099003 | vesicle-mediated transport in synapse | 130 | 169 | 4.10e-03 |
| GO:BP | GO:0010817 | regulation of hormone levels | 233 | 318 | 4.14e-03 |
| GO:BP | GO:0050768 | negative regulation of neurogenesis | 83 | 103 | 4.27e-03 |
| GO:BP | GO:0051051 | negative regulation of transport | 211 | 286 | 4.31e-03 |
| GO:BP | GO:0002521 | leukocyte differentiation | 269 | 371 | 4.31e-03 |
| GO:BP | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 108 | 138 | 4.37e-03 |
| GO:BP | GO:1902905 | positive regulation of supramolecular fiber organization | 108 | 138 | 4.37e-03 |
| GO:BP | GO:0006909 | phagocytosis | 108 | 138 | 4.37e-03 |
| GO:BP | GO:0048469 | cell maturation | 88 | 110 | 4.37e-03 |
| GO:BP | GO:0051492 | regulation of stress fiber assembly | 64 | 77 | 4.39e-03 |
| GO:BP | GO:0031325 | positive regulation of cellular metabolic process | 1559 | 2333 | 4.39e-03 |
| GO:BP | GO:0021953 | central nervous system neuron differentiation | 80 | 99 | 4.60e-03 |
| GO:BP | GO:0003300 | cardiac muscle hypertrophy | 61 | 73 | 4.61e-03 |
| GO:BP | GO:0007259 | receptor signaling pathway via JAK-STAT | 72 | 88 | 4.62e-03 |
| GO:BP | GO:0010632 | regulation of epithelial cell migration | 143 | 188 | 4.83e-03 |
| GO:BP | GO:0098771 | inorganic ion homeostasis | 253 | 348 | 4.95e-03 |
| GO:BP | GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels | 52 | 61 | 4.98e-03 |
| GO:BP | GO:0061614 | miRNA transcription | 52 | 61 | 4.98e-03 |
| GO:BP | GO:0036211 | protein modification process | 1531 | 2291 | 4.98e-03 |
| GO:BP | GO:0018105 | peptidyl-serine phosphorylation | 124 | 161 | 5.05e-03 |
| GO:BP | GO:0031099 | regeneration | 112 | 144 | 5.09e-03 |
| GO:BP | GO:0007179 | transforming growth factor beta receptor signaling pathway | 131 | 171 | 5.09e-03 |
| GO:BP | GO:0001508 | action potential | 82 | 102 | 5.19e-03 |
| GO:BP | GO:0045664 | regulation of neuron differentiation | 102 | 130 | 5.33e-03 |
| GO:BP | GO:0034764 | positive regulation of transmembrane transport | 102 | 130 | 5.33e-03 |
| GO:BP | GO:1903530 | regulation of secretion by cell | 265 | 366 | 5.34e-03 |
| GO:BP | GO:0097696 | receptor signaling pathway via STAT | 74 | 91 | 5.34e-03 |
| GO:BP | GO:0099173 | postsynapse organization | 114 | 147 | 5.45e-03 |
| GO:BP | GO:0035113 | embryonic appendage morphogenesis | 71 | 87 | 5.77e-03 |
| GO:BP | GO:0030326 | embryonic limb morphogenesis | 71 | 87 | 5.77e-03 |
| GO:BP | GO:0046622 | positive regulation of organ growth | 32 | 35 | 5.77e-03 |
| GO:BP | GO:0042063 | gliogenesis | 180 | 242 | 5.95e-03 |
| GO:BP | GO:0008366 | axon ensheathment | 94 | 119 | 5.95e-03 |
| GO:BP | GO:0007272 | ensheathment of neurons | 94 | 119 | 5.95e-03 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | 738 | 1077 | 5.96e-03 |
| GO:BP | GO:1902533 | positive regulation of intracellular signal transduction | 498 | 714 | 5.99e-03 |
| GO:BP | GO:0051046 | regulation of secretion | 285 | 396 | 5.99e-03 |
| GO:BP | GO:0023061 | signal release | 230 | 315 | 5.99e-03 |
| GO:BP | GO:0030500 | regulation of bone mineralization | 42 | 48 | 6.06e-03 |
| GO:BP | GO:0046850 | regulation of bone remodeling | 28 | 30 | 6.06e-03 |
| GO:BP | GO:0030097 | hemopoiesis | 438 | 624 | 6.06e-03 |
| GO:BP | GO:0048736 | appendage development | 106 | 136 | 6.18e-03 |
| GO:BP | GO:0060173 | limb development | 106 | 136 | 6.18e-03 |
| GO:BP | GO:0060341 | regulation of cellular localization | 539 | 776 | 6.18e-03 |
| GO:BP | GO:0090596 | sensory organ morphogenesis | 132 | 173 | 6.26e-03 |
| GO:BP | GO:0002376 | immune system process | 956 | 1410 | 6.44e-03 |
| GO:BP | GO:0110053 | regulation of actin filament organization | 159 | 212 | 6.73e-03 |
| GO:BP | GO:0031399 | regulation of protein modification process | 628 | 911 | 6.73e-03 |
| GO:BP | GO:0014896 | muscle hypertrophy | 62 | 75 | 6.97e-03 |
| GO:BP | GO:0018209 | peptidyl-serine modification | 129 | 169 | 7.06e-03 |
| GO:BP | GO:0007173 | epidermal growth factor receptor signaling pathway | 70 | 86 | 7.13e-03 |
| GO:BP | GO:0071407 | cellular response to organic cyclic compound | 273 | 379 | 7.15e-03 |
| GO:BP | GO:0048813 | dendrite morphogenesis | 88 | 111 | 7.16e-03 |
| GO:BP | GO:0046777 | protein autophosphorylation | 110 | 142 | 7.19e-03 |
| GO:BP | GO:0010721 | negative regulation of cell development | 138 | 182 | 7.31e-03 |
| GO:BP | GO:0021543 | pallium development | 105 | 135 | 7.45e-03 |
| GO:BP | GO:0043410 | positive regulation of MAPK cascade | 211 | 288 | 7.49e-03 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | 1076 | 1595 | 7.49e-03 |
| GO:BP | GO:0120031 | plasma membrane bounded cell projection assembly | 312 | 437 | 7.49e-03 |
| GO:BP | GO:0007162 | negative regulation of cell adhesion | 140 | 185 | 7.64e-03 |
| GO:BP | GO:0051495 | positive regulation of cytoskeleton organization | 112 | 145 | 7.67e-03 |
| GO:BP | GO:0071711 | basement membrane organization | 31 | 34 | 7.74e-03 |
| GO:BP | GO:0032330 | regulation of chondrocyte differentiation | 31 | 34 | 7.74e-03 |
| GO:BP | GO:1990845 | adaptive thermogenesis | 95 | 121 | 7.74e-03 |
| GO:BP | GO:0033043 | regulation of organelle organization | 655 | 953 | 7.85e-03 |
| GO:BP | GO:0014743 | regulation of muscle hypertrophy | 41 | 47 | 7.91e-03 |
| GO:BP | GO:0098868 | bone growth | 23 | 24 | 7.95e-03 |
| GO:BP | GO:0021952 | central nervous system projection neuron axonogenesis | 23 | 24 | 7.95e-03 |
| GO:BP | GO:0050773 | regulation of dendrite development | 64 | 78 | 8.09e-03 |
| GO:BP | GO:0030282 | bone mineralization | 64 | 78 | 8.09e-03 |
| GO:BP | GO:0010743 | regulation of macrophage derived foam cell differentiation | 18 | 18 | 8.15e-03 |
| GO:BP | GO:1990776 | response to angiotensin | 27 | 29 | 8.32e-03 |
| GO:BP | GO:0150117 | positive regulation of cell-substrate junction organization | 27 | 29 | 8.32e-03 |
| GO:BP | GO:0033036 | macromolecule localization | 1539 | 2309 | 8.54e-03 |
| GO:BP | GO:0042552 | myelination | 92 | 117 | 8.54e-03 |
| GO:BP | GO:0003206 | cardiac chamber morphogenesis | 87 | 110 | 8.58e-03 |
| GO:BP | GO:0043270 | positive regulation of monoatomic ion transport | 99 | 127 | 9.13e-03 |
| GO:BP | GO:0060249 | anatomical structure homeostasis | 125 | 164 | 9.15e-03 |
| GO:BP | GO:0046620 | regulation of organ growth | 58 | 70 | 9.15e-03 |
| GO:BP | GO:0001894 | tissue homeostasis | 125 | 164 | 9.15e-03 |
| GO:BP | GO:0030031 | cell projection assembly | 318 | 447 | 9.45e-03 |
| GO:BP | GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 89 | 113 | 9.46e-03 |
| GO:BP | GO:0031214 | biomineral tissue development | 84 | 106 | 9.47e-03 |
| GO:BP | GO:0007043 | cell-cell junction assembly | 84 | 106 | 9.47e-03 |
| GO:BP | GO:0046942 | carboxylic acid transport | 152 | 203 | 9.60e-03 |
| GO:BP | GO:0007517 | muscle organ development | 196 | 267 | 9.60e-03 |
| GO:BP | GO:0040008 | regulation of growth | 328 | 462 | 9.60e-03 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | 183 | 248 | 9.60e-03 |
| GO:BP | GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 120 | 157 | 9.60e-03 |
| GO:BP | GO:0001659 | temperature homeostasis | 101 | 130 | 9.71e-03 |
| GO:BP | GO:0061387 | regulation of extent of cell growth | 71 | 88 | 9.90e-03 |
| GO:BP | GO:0032271 | regulation of protein polymerization | 122 | 160 | 1.02e-02 |
| GO:BP | GO:0060048 | cardiac muscle contraction | 91 | 116 | 1.02e-02 |
| GO:BP | GO:0048675 | axon extension | 76 | 95 | 1.02e-02 |
| GO:BP | GO:0010611 | regulation of cardiac muscle hypertrophy | 40 | 46 | 1.03e-02 |
| GO:BP | GO:0060350 | endochondral bone morphogenesis | 40 | 46 | 1.03e-02 |
| GO:BP | GO:0051961 | negative regulation of nervous system development | 86 | 109 | 1.03e-02 |
| GO:BP | GO:0018193 | peptidyl-amino acid modification | 390 | 555 | 1.03e-02 |
| GO:BP | GO:0014070 | response to organic cyclic compound | 424 | 606 | 1.03e-02 |
| GO:BP | GO:0086065 | cell communication involved in cardiac conduction | 46 | 54 | 1.04e-02 |
| GO:BP | GO:0051924 | regulation of calcium ion transport | 117 | 153 | 1.07e-02 |
| GO:BP | GO:0060349 | bone morphogenesis | 60 | 73 | 1.07e-02 |
| GO:BP | GO:0006937 | regulation of muscle contraction | 98 | 126 | 1.07e-02 |
| GO:BP | GO:0007611 | learning or memory | 142 | 189 | 1.11e-02 |
| GO:BP | GO:0003416 | endochondral bone growth | 22 | 23 | 1.11e-02 |
| GO:BP | GO:0007159 | leukocyte cell-cell adhesion | 162 | 218 | 1.12e-02 |
| GO:BP | GO:0016266 | O-glycan processing | 26 | 28 | 1.14e-02 |
| GO:BP | GO:0006887 | exocytosis | 175 | 237 | 1.16e-02 |
| GO:BP | GO:0022407 | regulation of cell-cell adhesion | 203 | 278 | 1.18e-02 |
| GO:BP | GO:0032528 | microvillus organization | 17 | 17 | 1.18e-02 |
| GO:BP | GO:0070727 | cellular macromolecule localization | 1343 | 2010 | 1.18e-02 |
| GO:BP | GO:0060491 | regulation of cell projection assembly | 121 | 159 | 1.18e-02 |
| GO:BP | GO:0015800 | acidic amino acid transport | 33 | 37 | 1.19e-02 |
| GO:BP | GO:0002685 | regulation of leukocyte migration | 95 | 122 | 1.19e-02 |
| GO:BP | GO:0098739 | import across plasma membrane | 95 | 122 | 1.19e-02 |
| GO:BP | GO:0060291 | long-term synaptic potentiation | 54 | 65 | 1.19e-02 |
| GO:BP | GO:0032272 | negative regulation of protein polymerization | 54 | 65 | 1.19e-02 |
| GO:BP | GO:0007613 | memory | 70 | 87 | 1.20e-02 |
| GO:BP | GO:0097191 | extrinsic apoptotic signaling pathway | 130 | 172 | 1.21e-02 |
| GO:BP | GO:0003231 | cardiac ventricle development | 90 | 115 | 1.21e-02 |
| GO:BP | GO:1901342 | regulation of vasculature development | 148 | 198 | 1.22e-02 |
| GO:BP | GO:1901890 | positive regulation of cell junction assembly | 62 | 76 | 1.23e-02 |
| GO:BP | GO:0033002 | muscle cell proliferation | 116 | 152 | 1.24e-02 |
| GO:BP | GO:0048678 | response to axon injury | 51 | 61 | 1.25e-02 |
| GO:BP | GO:0008104 | protein localization | 1336 | 2000 | 1.26e-02 |
| GO:BP | GO:0031103 | axon regeneration | 36 | 41 | 1.27e-02 |
| GO:BP | GO:0051899 | membrane depolarization | 48 | 57 | 1.30e-02 |
| GO:BP | GO:0050921 | positive regulation of chemotaxis | 67 | 83 | 1.30e-02 |
| GO:BP | GO:0015849 | organic acid transport | 152 | 204 | 1.30e-02 |
| GO:BP | GO:0050790 | regulation of catalytic activity | 613 | 893 | 1.31e-02 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | 59 | 72 | 1.32e-02 |
| GO:BP | GO:1903053 | regulation of extracellular matrix organization | 42 | 49 | 1.34e-02 |
| GO:BP | GO:0006954 | inflammatory response | 302 | 425 | 1.35e-02 |
| GO:BP | GO:0030855 | epithelial cell differentiation | 304 | 428 | 1.35e-02 |
| GO:BP | GO:0045765 | regulation of angiogenesis | 145 | 194 | 1.35e-02 |
| GO:BP | GO:0060562 | epithelial tube morphogenesis | 191 | 261 | 1.35e-02 |
| GO:BP | GO:0042325 | regulation of phosphorylation | 474 | 683 | 1.37e-02 |
| GO:BP | GO:0043068 | positive regulation of programmed cell death | 277 | 388 | 1.39e-02 |
| GO:BP | GO:0045927 | positive regulation of growth | 138 | 184 | 1.41e-02 |
| GO:BP | GO:0099504 | synaptic vesicle cycle | 115 | 151 | 1.46e-02 |
| GO:BP | GO:0010876 | lipid localization | 216 | 298 | 1.47e-02 |
| GO:BP | GO:0032880 | regulation of protein localization | 479 | 691 | 1.48e-02 |
| GO:BP | GO:0086003 | cardiac muscle cell contraction | 53 | 64 | 1.50e-02 |
| GO:BP | GO:0055017 | cardiac muscle tissue growth | 53 | 64 | 1.50e-02 |
| GO:BP | GO:1904646 | cellular response to amyloid-beta | 25 | 27 | 1.55e-02 |
| GO:BP | GO:1904385 | cellular response to angiotensin | 25 | 27 | 1.55e-02 |
| GO:BP | GO:0010634 | positive regulation of epithelial cell migration | 98 | 127 | 1.63e-02 |
| GO:BP | GO:0060419 | heart growth | 58 | 71 | 1.66e-02 |
| GO:BP | GO:0050673 | epithelial cell proliferation | 217 | 300 | 1.70e-02 |
| GO:BP | GO:0071805 | potassium ion transmembrane transport | 93 | 120 | 1.70e-02 |
| GO:BP | GO:0048568 | embryonic organ development | 219 | 303 | 1.71e-02 |
| GO:BP | GO:0051653 | spindle localization | 44 | 52 | 1.71e-02 |
| GO:BP | GO:0021846 | cell proliferation in forebrain | 16 | 16 | 1.71e-02 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | 202 | 278 | 1.72e-02 |
| GO:BP | GO:0006874 | intracellular calcium ion homeostasis | 150 | 202 | 1.74e-02 |
| GO:BP | GO:0051058 | negative regulation of small GTPase mediated signal transduction | 41 | 48 | 1.74e-02 |
| GO:BP | GO:0031102 | neuron projection regeneration | 41 | 48 | 1.74e-02 |
| GO:BP | GO:0055006 | cardiac cell development | 63 | 78 | 1.75e-02 |
| GO:BP | GO:0055001 | muscle cell development | 123 | 163 | 1.76e-02 |
| GO:BP | GO:0010717 | regulation of epithelial to mesenchymal transition | 68 | 85 | 1.81e-02 |
| GO:BP | GO:1904645 | response to amyloid-beta | 28 | 31 | 1.90e-02 |
| GO:BP | GO:0032411 | positive regulation of transporter activity | 52 | 63 | 1.90e-02 |
| GO:BP | GO:0031644 | regulation of nervous system process | 60 | 74 | 1.91e-02 |
| GO:BP | GO:0048864 | stem cell development | 60 | 74 | 1.91e-02 |
| GO:BP | GO:0016049 | cell growth | 272 | 382 | 1.92e-02 |
| GO:BP | GO:0000003 | reproduction | 604 | 882 | 1.92e-02 |
| GO:BP | GO:0006942 | regulation of striated muscle contraction | 65 | 81 | 1.99e-02 |
| GO:BP | GO:0003279 | cardiac septum development | 80 | 102 | 2.00e-02 |
| GO:BP | GO:0010638 | positive regulation of organelle organization | 290 | 409 | 2.01e-02 |
| GO:BP | GO:0014855 | striated muscle cell proliferation | 49 | 59 | 2.01e-02 |
| GO:BP | GO:0007265 | Ras protein signal transduction | 75 | 95 | 2.02e-02 |
| GO:BP | GO:0043588 | skin development | 131 | 175 | 2.07e-02 |
| GO:BP | GO:0106106 | cold-induced thermogenesis | 87 | 112 | 2.10e-02 |
| GO:BP | GO:0008038 | neuron recognition | 31 | 35 | 2.11e-02 |
| GO:BP | GO:0045663 | positive regulation of myoblast differentiation | 31 | 35 | 2.11e-02 |
| GO:BP | GO:0021799 | cerebral cortex radially oriented cell migration | 24 | 26 | 2.16e-02 |
| GO:BP | GO:0051235 | maintenance of location | 183 | 251 | 2.20e-02 |
| GO:BP | GO:0045667 | regulation of osteoblast differentiation | 77 | 98 | 2.22e-02 |
| GO:BP | GO:0046578 | regulation of Ras protein signal transduction | 34 | 39 | 2.23e-02 |
| GO:BP | GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 72 | 91 | 2.24e-02 |
| GO:BP | GO:0045665 | negative regulation of neuron differentiation | 37 | 43 | 2.27e-02 |
| GO:BP | GO:0002090 | regulation of receptor internalization | 37 | 43 | 2.27e-02 |
| GO:BP | GO:0055074 | calcium ion homeostasis | 159 | 216 | 2.27e-02 |
| GO:BP | GO:0006813 | potassium ion transport | 103 | 135 | 2.29e-02 |
| GO:BP | GO:1903169 | regulation of calcium ion transmembrane transport | 84 | 108 | 2.34e-02 |
| GO:BP | GO:0043065 | positive regulation of apoptotic process | 270 | 380 | 2.37e-02 |
| GO:BP | GO:0070167 | regulation of biomineral tissue development | 51 | 62 | 2.39e-02 |
| GO:BP | GO:0044272 | sulfur compound biosynthetic process | 98 | 128 | 2.44e-02 |
| GO:BP | GO:0010586 | miRNA metabolic process | 69 | 87 | 2.47e-02 |
| GO:BP | GO:0048593 | camera-type eye morphogenesis | 69 | 87 | 2.47e-02 |
| GO:BP | GO:1904375 | regulation of protein localization to cell periphery | 86 | 111 | 2.52e-02 |
| GO:BP | GO:0120161 | regulation of cold-induced thermogenesis | 86 | 111 | 2.52e-02 |
| GO:BP | GO:0032414 | positive regulation of ion transmembrane transporter activity | 48 | 58 | 2.55e-02 |
| GO:BP | GO:0001974 | blood vessel remodeling | 27 | 30 | 2.57e-02 |
| GO:BP | GO:1904707 | positive regulation of vascular associated smooth muscle cell proliferation | 27 | 30 | 2.57e-02 |
| GO:BP | GO:0120162 | positive regulation of cold-induced thermogenesis | 56 | 69 | 2.57e-02 |
| GO:BP | GO:0046486 | glycerolipid metabolic process | 205 | 284 | 2.57e-02 |
| GO:BP | GO:0051146 | striated muscle cell differentiation | 171 | 234 | 2.57e-02 |
| GO:BP | GO:0071396 | cellular response to lipid | 275 | 388 | 2.66e-02 |
| GO:BP | GO:0006950 | response to stress | 1680 | 2540 | 2.66e-02 |
| GO:BP | GO:0014910 | regulation of smooth muscle cell migration | 45 | 54 | 2.69e-02 |
| GO:BP | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 66 | 83 | 2.72e-02 |
| GO:BP | GO:0051648 | vesicle localization | 140 | 189 | 2.80e-02 |
| GO:BP | GO:0010927 | cellular component assembly involved in morphogenesis | 83 | 107 | 2.80e-02 |
| GO:BP | GO:0031667 | response to nutrient levels | 252 | 354 | 2.80e-02 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | 329 | 469 | 2.81e-02 |
| GO:BP | GO:0021795 | cerebral cortex cell migration | 30 | 34 | 2.81e-02 |
| GO:BP | GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 90 | 117 | 2.86e-02 |
| GO:BP | GO:0006629 | lipid metabolic process | 629 | 923 | 2.89e-02 |
| GO:BP | GO:0055013 | cardiac muscle cell development | 58 | 72 | 2.93e-02 |
| GO:BP | GO:0046503 | glycerolipid catabolic process | 33 | 38 | 2.93e-02 |
| GO:BP | GO:1904407 | positive regulation of nitric oxide metabolic process | 23 | 25 | 2.94e-02 |
| GO:BP | GO:0060351 | cartilage development involved in endochondral bone morphogenesis | 23 | 25 | 2.94e-02 |
| GO:BP | GO:0001954 | positive regulation of cell-matrix adhesion | 36 | 42 | 2.94e-02 |
| GO:BP | GO:0022612 | gland morphogenesis | 73 | 93 | 2.94e-02 |
| GO:BP | GO:0033993 | response to lipid | 398 | 573 | 2.94e-02 |
| GO:BP | GO:0030705 | cytoskeleton-dependent intracellular transport | 133 | 179 | 2.94e-02 |
| GO:BP | GO:0006869 | lipid transport | 189 | 261 | 2.96e-02 |
| GO:BP | GO:0030177 | positive regulation of Wnt signaling pathway | 85 | 110 | 2.97e-02 |
| GO:BP | GO:0051043 | regulation of membrane protein ectodomain proteolysis | 19 | 20 | 3.09e-02 |
| GO:BP | GO:0071675 | regulation of mononuclear cell migration | 55 | 68 | 3.18e-02 |
| GO:BP | GO:0019915 | lipid storage | 55 | 68 | 3.18e-02 |
| GO:BP | GO:0007584 | response to nutrient | 87 | 113 | 3.18e-02 |
| GO:BP | GO:0055123 | digestive system development | 75 | 96 | 3.20e-02 |
| GO:BP | GO:0006941 | striated muscle contraction | 110 | 146 | 3.22e-02 |
| GO:BP | GO:0009914 | hormone transport | 152 | 207 | 3.22e-02 |
| GO:BP | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 60 | 75 | 3.27e-02 |
| GO:BP | GO:0045321 | leukocyte activation | 369 | 530 | 3.29e-02 |
| GO:BP | GO:0007416 | synapse assembly | 103 | 136 | 3.31e-02 |
| GO:BP | GO:0046661 | male sex differentiation | 82 | 106 | 3.31e-02 |
| GO:BP | GO:0050806 | positive regulation of synaptic transmission | 82 | 106 | 3.31e-02 |
| GO:BP | GO:0022414 | reproductive process | 596 | 874 | 3.38e-02 |
| GO:BP | GO:2000649 | regulation of sodium ion transmembrane transporter activity | 26 | 29 | 3.43e-02 |
| GO:BP | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | 26 | 29 | 3.43e-02 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | 443 | 642 | 3.48e-02 |
| GO:BP | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 84 | 109 | 3.55e-02 |
| GO:BP | GO:1904705 | regulation of vascular associated smooth muscle cell proliferation | 41 | 49 | 3.56e-02 |
| GO:BP | GO:1903078 | positive regulation of protein localization to plasma membrane | 41 | 49 | 3.56e-02 |
| GO:BP | GO:0060998 | regulation of dendritic spine development | 41 | 49 | 3.56e-02 |
| GO:BP | GO:0060420 | regulation of heart growth | 41 | 49 | 3.56e-02 |
| GO:BP | GO:0106027 | neuron projection organization | 57 | 71 | 3.57e-02 |
| GO:BP | GO:0021700 | developmental maturation | 149 | 203 | 3.58e-02 |
| GO:BP | GO:0008037 | cell recognition | 62 | 78 | 3.62e-02 |
| GO:BP | GO:0040019 | positive regulation of embryonic development | 14 | 14 | 3.63e-02 |
| GO:BP | GO:0086069 | bundle of His cell to Purkinje myocyte communication | 14 | 14 | 3.63e-02 |
| GO:BP | GO:0030522 | intracellular receptor signaling pathway | 183 | 253 | 3.64e-02 |
| GO:BP | GO:0042100 | B cell proliferation | 38 | 45 | 3.68e-02 |
| GO:BP | GO:0007260 | tyrosine phosphorylation of STAT protein | 29 | 33 | 3.68e-02 |
| GO:BP | GO:0015711 | organic anion transport | 185 | 256 | 3.68e-02 |
| GO:BP | GO:1904377 | positive regulation of protein localization to cell periphery | 49 | 60 | 3.68e-02 |
| GO:BP | GO:0001763 | morphogenesis of a branching structure | 109 | 145 | 3.71e-02 |
| GO:BP | GO:0045453 | bone resorption | 35 | 41 | 3.76e-02 |
| GO:BP | GO:0010171 | body morphogenesis | 35 | 41 | 3.76e-02 |
| GO:BP | GO:1903115 | regulation of actin filament-based movement | 32 | 37 | 3.77e-02 |
| GO:BP | GO:0010811 | positive regulation of cell-substrate adhesion | 74 | 95 | 3.79e-02 |
| GO:BP | GO:0050870 | positive regulation of T cell activation | 102 | 135 | 3.82e-02 |
| GO:BP | GO:0008154 | actin polymerization or depolymerization | 111 | 148 | 3.84e-02 |
| GO:BP | GO:0002064 | epithelial cell development | 111 | 148 | 3.84e-02 |
| GO:BP | GO:1901343 | negative regulation of vasculature development | 54 | 67 | 3.85e-02 |
| GO:BP | GO:0060411 | cardiac septum morphogenesis | 54 | 67 | 3.85e-02 |
| GO:BP | GO:2000181 | negative regulation of blood vessel morphogenesis | 54 | 67 | 3.85e-02 |
| GO:BP | GO:1903076 | regulation of protein localization to plasma membrane | 69 | 88 | 3.87e-02 |
| GO:BP | GO:0006638 | neutral lipid metabolic process | 69 | 88 | 3.87e-02 |
| GO:BP | GO:0008217 | regulation of blood pressure | 81 | 105 | 3.87e-02 |
| GO:BP | GO:0060041 | retina development in camera-type eye | 81 | 105 | 3.87e-02 |
| GO:BP | GO:1902107 | positive regulation of leukocyte differentiation | 88 | 115 | 3.89e-02 |
| GO:BP | GO:1903708 | positive regulation of hemopoiesis | 88 | 115 | 3.89e-02 |
| GO:BP | GO:0001823 | mesonephros development | 59 | 74 | 3.89e-02 |
| GO:BP | GO:0030516 | regulation of axon extension | 59 | 74 | 3.89e-02 |
| GO:BP | GO:0003229 | ventricular cardiac muscle tissue development | 46 | 56 | 3.89e-02 |
| GO:BP | GO:0051894 | positive regulation of focal adhesion assembly | 22 | 24 | 3.92e-02 |
| GO:BP | GO:0045429 | positive regulation of nitric oxide biosynthetic process | 22 | 24 | 3.92e-02 |
| GO:BP | GO:0002431 | Fc receptor mediated stimulatory signaling pathway | 22 | 24 | 3.92e-02 |
| GO:BP | GO:0045124 | regulation of bone resorption | 22 | 24 | 3.92e-02 |
| GO:BP | GO:0050678 | regulation of epithelial cell proliferation | 180 | 249 | 3.95e-02 |
| GO:BP | GO:0046879 | hormone secretion | 148 | 202 | 3.97e-02 |
| GO:BP | GO:0007389 | pattern specification process | 205 | 286 | 3.99e-02 |
| GO:BP | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 71 | 91 | 4.16e-02 |
| GO:BP | GO:0071378 | cellular response to growth hormone stimulus | 18 | 19 | 4.23e-02 |
| GO:BP | GO:0051650 | establishment of vesicle localization | 128 | 173 | 4.23e-02 |
| GO:BP | GO:0035270 | endocrine system development | 66 | 84 | 4.26e-02 |
| GO:BP | GO:0002684 | positive regulation of immune system process | 401 | 580 | 4.27e-02 |
| GO:BP | GO:1901879 | regulation of protein depolymerization | 56 | 70 | 4.28e-02 |
| GO:BP | GO:0014033 | neural crest cell differentiation | 61 | 77 | 4.30e-02 |
| GO:BP | GO:0072073 | kidney epithelium development | 85 | 111 | 4.33e-02 |
| GO:BP | GO:0001755 | neural crest cell migration | 40 | 48 | 4.41e-02 |
| GO:BP | GO:0051293 | establishment of spindle localization | 40 | 48 | 4.41e-02 |
| GO:BP | GO:0015833 | peptide transport | 132 | 179 | 4.44e-02 |
| GO:BP | GO:0060421 | positive regulation of heart growth | 25 | 28 | 4.49e-02 |
| GO:BP | GO:0030041 | actin filament polymerization | 94 | 124 | 4.51e-02 |
| GO:BP | GO:0042060 | wound healing | 208 | 291 | 4.55e-02 |
| GO:BP | GO:0030073 | insulin secretion | 103 | 137 | 4.57e-02 |
| GO:BP | GO:0055021 | regulation of cardiac muscle tissue growth | 37 | 44 | 4.60e-02 |
| GO:BP | GO:0006639 | acylglycerol metabolic process | 68 | 87 | 4.60e-02 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | 37 | 44 | 4.60e-02 |
| GO:BP | GO:0086002 | cardiac muscle cell action potential involved in contraction | 37 | 44 | 4.60e-02 |
| GO:BP | GO:0003006 | developmental process involved in reproduction | 396 | 573 | 4.63e-02 |
| GO:BP | GO:0051668 | localization within membrane | 392 | 567 | 4.66e-02 |
| GO:BP | GO:0071230 | cellular response to amino acid stimulus | 53 | 66 | 4.66e-02 |
| GO:BP | GO:0016525 | negative regulation of angiogenesis | 53 | 66 | 4.66e-02 |
| GO:BP | GO:0007369 | gastrulation | 105 | 140 | 4.71e-02 |
| GO:BP | GO:0072164 | mesonephric tubule development | 58 | 73 | 4.71e-02 |
| GO:BP | GO:0072163 | mesonephric epithelium development | 58 | 73 | 4.71e-02 |
| GO:BP | GO:0042509 | regulation of tyrosine phosphorylation of STAT protein | 28 | 32 | 4.71e-02 |
| GO:BP | GO:0086004 | regulation of cardiac muscle cell contraction | 28 | 32 | 4.71e-02 |
| GO:BP | GO:0098927 | vesicle-mediated transport between endosomal compartments | 34 | 40 | 4.72e-02 |
| GO:BP | GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 75 | 97 | 4.72e-02 |
| GO:BP | GO:0006865 | amino acid transport | 75 | 97 | 4.72e-02 |
| GO:BP | GO:0038179 | neurotrophin signaling pathway | 31 | 36 | 4.77e-02 |
| GO:BP | GO:0031641 | regulation of myelination | 31 | 36 | 4.77e-02 |
| GO:BP | GO:0003073 | regulation of systemic arterial blood pressure | 45 | 55 | 4.79e-02 |
| GO:BP | GO:0042246 | tissue regeneration | 45 | 55 | 4.79e-02 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | 232 | 327 | 4.79e-02 |
| GO:BP | GO:0002682 | regulation of immune system process | 590 | 868 | 4.85e-02 |
LRnomtable_20k %>%
filter(source=="KEGG", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in LR nESRgenes_20k") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:04360 | Axon guidance | 130 | 155 | 5.82e-06 |
| KEGG | KEGG:04971 | Gastric acid secretion | 49 | 51 | 6.86e-06 |
| KEGG | KEGG:04022 | cGMP-PKG signaling pathway | 109 | 129 | 8.01e-06 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | 133 | 162 | 8.01e-06 |
| KEGG | KEGG:04024 | cAMP signaling pathway | 122 | 147 | 8.01e-06 |
| KEGG | KEGG:04520 | Adherens junction | 74 | 83 | 8.01e-06 |
| KEGG | KEGG:04270 | Vascular smooth muscle contraction | 81 | 92 | 8.01e-06 |
| KEGG | KEGG:04020 | Calcium signaling pathway | 132 | 161 | 9.13e-06 |
| KEGG | KEGG:04911 | Insulin secretion | 57 | 62 | 9.72e-06 |
| KEGG | KEGG:04014 | Ras signaling pathway | 134 | 164 | 9.72e-06 |
| KEGG | KEGG:04925 | Aldosterone synthesis and secretion | 67 | 75 | 1.26e-05 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | 137 | 169 | 1.34e-05 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 69 | 78 | 1.74e-05 |
| KEGG | KEGG:04510 | Focal adhesion | 136 | 169 | 2.83e-05 |
| KEGG | KEGG:04611 | Platelet activation | 76 | 88 | 3.64e-05 |
| KEGG | KEGG:04974 | Protein digestion and absorption | 51 | 56 | 5.62e-05 |
| KEGG | KEGG:04927 | Cortisol synthesis and secretion | 43 | 46 | 5.69e-05 |
| KEGG | KEGG:05200 | Pathways in cancer | 290 | 391 | 6.90e-05 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | 102 | 124 | 6.90e-05 |
| KEGG | KEGG:04970 | Salivary secretion | 49 | 54 | 9.33e-05 |
| KEGG | KEGG:05146 | Amoebiasis | 55 | 62 | 1.27e-04 |
| KEGG | KEGG:04010 | MAPK signaling pathway | 177 | 231 | 1.88e-04 |
| KEGG | KEGG:04750 | Inflammatory mediator regulation of TRP channels | 62 | 72 | 2.63e-04 |
| KEGG | KEGG:04713 | Circadian entrainment | 59 | 68 | 2.63e-04 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | 126 | 160 | 3.03e-04 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | 189 | 250 | 3.54e-04 |
| KEGG | KEGG:04961 | Endocrine and other factor-regulated calcium reabsorption | 37 | 40 | 3.64e-04 |
| KEGG | KEGG:04512 | ECM-receptor interaction | 57 | 66 | 4.11e-04 |
| KEGG | KEGG:04918 | Thyroid hormone synthesis | 47 | 53 | 4.46e-04 |
| KEGG | KEGG:04972 | Pancreatic secretion | 50 | 57 | 4.65e-04 |
| KEGG | KEGG:04730 | Long-term depression | 36 | 39 | 4.65e-04 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 126 | 162 | 6.91e-04 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | 72 | 87 | 7.24e-04 |
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | 57 | 67 | 8.62e-04 |
| KEGG | KEGG:04728 | Dopaminergic synapse | 79 | 97 | 9.25e-04 |
| KEGG | KEGG:04924 | Renin secretion | 44 | 50 | 9.91e-04 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | 81 | 100 | 1.02e-03 |
| KEGG | KEGG:04976 | Bile secretion | 37 | 41 | 1.02e-03 |
| KEGG | KEGG:04148 | Efferocytosis | 95 | 120 | 1.37e-03 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | 73 | 90 | 1.91e-03 |
| KEGG | KEGG:05135 | Yersinia infection | 85 | 107 | 2.20e-03 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | 67 | 82 | 2.20e-03 |
| KEGG | KEGG:04072 | Phospholipase D signaling pathway | 85 | 107 | 2.20e-03 |
| KEGG | KEGG:04720 | Long-term potentiation | 44 | 51 | 2.26e-03 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | 77 | 96 | 2.30e-03 |
| KEGG | KEGG:04726 | Serotonergic synapse | 49 | 58 | 2.90e-03 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | 110 | 143 | 2.96e-03 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | 62 | 76 | 3.51e-03 |
| KEGG | KEGG:00000 | KEGG root term | 3552 | 5451 | 3.54e-03 |
| KEGG | KEGG:04371 | Apelin signaling pathway | 82 | 104 | 3.80e-03 |
| KEGG | KEGG:04725 | Cholinergic synapse | 66 | 82 | 4.54e-03 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | 88 | 113 | 4.91e-03 |
| KEGG | KEGG:04310 | Wnt signaling pathway | 102 | 133 | 5.10e-03 |
| KEGG | KEGG:04724 | Glutamatergic synapse | 60 | 74 | 5.24e-03 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | 62 | 77 | 5.99e-03 |
| KEGG | KEGG:04144 | Endocytosis | 159 | 216 | 6.22e-03 |
| KEGG | KEGG:04530 | Tight junction | 98 | 129 | 1.04e-02 |
| KEGG | KEGG:04659 | Th17 cell differentiation | 49 | 60 | 1.07e-02 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | 100 | 132 | 1.07e-02 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | 81 | 105 | 1.11e-02 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | 59 | 74 | 1.11e-02 |
| KEGG | KEGG:04960 | Aldosterone-regulated sodium reabsorption | 22 | 24 | 1.11e-02 |
| KEGG | KEGG:04912 | GnRH signaling pathway | 59 | 74 | 1.11e-02 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | 78 | 101 | 1.19e-02 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | 66 | 84 | 1.19e-02 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | 63 | 80 | 1.30e-02 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | 58 | 73 | 1.30e-02 |
| KEGG | KEGG:04070 | Phosphatidylinositol signaling system | 65 | 83 | 1.41e-02 |
| KEGG | KEGG:04514 | Cell adhesion molecules | 55 | 69 | 1.42e-02 |
| KEGG | KEGG:04071 | Sphingolipid signaling pathway | 79 | 103 | 1.46e-02 |
| KEGG | KEGG:03320 | PPAR signaling pathway | 39 | 47 | 1.49e-02 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | 57 | 72 | 1.54e-02 |
| KEGG | KEGG:05032 | Morphine addiction | 44 | 54 | 1.61e-02 |
| KEGG | KEGG:04916 | Melanogenesis | 59 | 75 | 1.64e-02 |
| KEGG | KEGG:04012 | ErbB signaling pathway | 59 | 75 | 1.64e-02 |
| KEGG | KEGG:00564 | Glycerophospholipid metabolism | 56 | 71 | 1.84e-02 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | 110 | 149 | 2.20e-02 |
| KEGG | KEGG:04630 | JAK-STAT signaling pathway | 64 | 83 | 2.57e-02 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | 82 | 109 | 2.68e-02 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | 82 | 109 | 2.68e-02 |
| KEGG | KEGG:00512 | Mucin type O-glycan biosynthesis | 19 | 21 | 2.68e-02 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | 99 | 134 | 3.01e-02 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | 105 | 143 | 3.23e-02 |
| KEGG | KEGG:05210 | Colorectal cancer | 62 | 81 | 3.50e-02 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | 78 | 104 | 3.50e-02 |
| KEGG | KEGG:04742 | Taste transduction | 18 | 20 | 3.50e-02 |
| KEGG | KEGG:04931 | Insulin resistance | 69 | 91 | 3.50e-02 |
| KEGG | KEGG:04390 | Hippo signaling pathway | 95 | 129 | 3.79e-02 |
| KEGG | KEGG:05165 | Human papillomavirus infection | 178 | 252 | 3.97e-02 |
| KEGG | KEGG:01212 | Fatty acid metabolism | 37 | 46 | 4.08e-02 |
| KEGG | KEGG:04068 | FoxO signaling pathway | 79 | 106 | 4.10e-02 |
| KEGG | KEGG:00514 | Other types of O-glycan biosynthesis | 29 | 35 | 4.12e-02 |
| KEGG | KEGG:04930 | Type II diabetes mellitus | 29 | 35 | 4.12e-02 |
| KEGG | KEGG:00280 | Valine, leucine and isoleucine degradation | 34 | 42 | 4.33e-02 |
| KEGG | KEGG:04664 | Fc epsilon RI signaling pathway | 34 | 42 | 4.33e-02 |
| KEGG | KEGG:04723 | Retrograde endocannabinoid signaling | 69 | 92 | 4.64e-02 |
| KEGG | KEGG:04380 | Osteoclast differentiation | 69 | 92 | 4.64e-02 |
| KEGG | KEGG:01040 | Biosynthesis of unsaturated fatty acids | 20 | 23 | 4.64e-02 |
| KEGG | KEGG:04727 | GABAergic synapse | 41 | 52 | 4.67e-02 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | 41 | 52 | 4.67e-02 |
| KEGG | KEGG:05031 | Amphetamine addiction | 36 | 45 | 4.68e-02 |
| KEGG | KEGG:05131 | Shigellosis | 145 | 204 | 4.69e-02 |
| KEGG | KEGG:04211 | Longevity regulating pathway | 57 | 75 | 4.95e-02 |
| KEGG | KEGG:04152 | AMPK signaling pathway | 75 | 101 | 4.95e-02 |
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | 57 | 75 | 4.95e-02 |
LR peaks overlapping enhancers
# LR_resgenes_20k_enh <- gost(query = unique(LR_enh_peaks_20k$NCBI_gene),
# organism = "hsapiens",
# significant = FALSE,
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = background_df$ENTREZID,
# sources=c("GO:BP","KEGG"))
# saveRDS(LR_resgenes_20k_enh,"data/GO_KEGG_analysis/LR_resgenes_20k_enh.RDS")
# LRnom <- gostplot(LR_resgenes_20k_enh, capped = FALSE, interactive = TRUE)
# LRnom
LRnomtable_20k_enh <- LR_resgenes_20k_enh$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
LRnomtable_20k_enh %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in LR neargenes_20k" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0050896 | response to stimulus | 1012 | 5379 | 1.25e-17 |
| GO:BP | GO:0007154 | cell communication | 789 | 3983 | 1.25e-17 |
| GO:BP | GO:0023052 | signaling | 778 | 3918 | 1.25e-17 |
| GO:BP | GO:0048856 | anatomical structure development | 768 | 3867 | 2.10e-17 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 434 | 1924 | 4.48e-17 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 418 | 1844 | 9.43e-17 |
| GO:BP | GO:0032501 | multicellular organismal process | 864 | 4504 | 3.39e-16 |
| GO:BP | GO:0007165 | signal transduction | 718 | 3611 | 4.68e-16 |
| GO:BP | GO:0007275 | multicellular organism development | 641 | 3170 | 2.41e-15 |
| GO:BP | GO:0051716 | cellular response to stimulus | 878 | 4640 | 7.34e-15 |
| GO:BP | GO:0032502 | developmental process | 803 | 4179 | 1.11e-14 |
| GO:BP | GO:0030029 | actin filament-based process | 176 | 640 | 2.32e-13 |
| GO:BP | GO:0072359 | circulatory system development | 220 | 864 | 4.21e-13 |
| GO:BP | GO:0048731 | system development | 553 | 2719 | 4.37e-13 |
| GO:BP | GO:0048519 | negative regulation of biological process | 725 | 3764 | 7.59e-13 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 690 | 3550 | 7.59e-13 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | 390 | 1801 | 2.55e-12 |
| GO:BP | GO:0050789 | regulation of biological process | 1301 | 7516 | 3.24e-12 |
| GO:BP | GO:0010646 | regulation of cell communication | 501 | 2444 | 3.51e-12 |
| GO:BP | GO:0007155 | cell adhesion | 231 | 941 | 3.82e-12 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 547 | 2717 | 3.82e-12 |
| GO:BP | GO:0048513 | animal organ development | 424 | 2004 | 4.73e-12 |
| GO:BP | GO:0061061 | muscle structure development | 149 | 536 | 1.04e-11 |
| GO:BP | GO:0023051 | regulation of signaling | 495 | 2438 | 2.67e-11 |
| GO:BP | GO:0065007 | biological regulation | 1326 | 7734 | 3.75e-11 |
| GO:BP | GO:0016477 | cell migration | 240 | 1011 | 4.70e-11 |
| GO:BP | GO:0009966 | regulation of signal transduction | 446 | 2166 | 6.97e-11 |
| GO:BP | GO:0031589 | cell-substrate adhesion | 86 | 258 | 8.53e-11 |
| GO:BP | GO:0009888 | tissue development | 301 | 1348 | 8.79e-11 |
| GO:BP | GO:0051146 | striated muscle cell differentiation | 79 | 234 | 3.46e-10 |
| GO:BP | GO:0030154 | cell differentiation | 550 | 2803 | 3.46e-10 |
| GO:BP | GO:0048869 | cellular developmental process | 550 | 2804 | 3.55e-10 |
| GO:BP | GO:0010810 | regulation of cell-substrate adhesion | 61 | 162 | 6.44e-10 |
| GO:BP | GO:0048870 | cell motility | 255 | 1120 | 7.91e-10 |
| GO:BP | GO:0044057 | regulation of system process | 111 | 384 | 1.08e-09 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | 148 | 566 | 1.56e-09 |
| GO:BP | GO:0050793 | regulation of developmental process | 357 | 1697 | 1.58e-09 |
| GO:BP | GO:0048518 | positive regulation of biological process | 788 | 4301 | 2.69e-09 |
| GO:BP | GO:0050794 | regulation of cellular process | 1227 | 7153 | 3.11e-09 |
| GO:BP | GO:0003013 | circulatory system process | 118 | 426 | 4.29e-09 |
| GO:BP | GO:0042692 | muscle cell differentiation | 96 | 323 | 4.89e-09 |
| GO:BP | GO:0008015 | blood circulation | 103 | 357 | 6.19e-09 |
| GO:BP | GO:0003012 | muscle system process | 96 | 325 | 6.85e-09 |
| GO:BP | GO:0030155 | regulation of cell adhesion | 133 | 508 | 1.45e-08 |
| GO:BP | GO:0040011 | locomotion | 190 | 805 | 2.19e-08 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | 173 | 717 | 2.53e-08 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 725 | 3954 | 2.89e-08 |
| GO:BP | GO:0060537 | muscle tissue development | 97 | 339 | 3.42e-08 |
| GO:BP | GO:0001568 | blood vessel development | 135 | 525 | 3.51e-08 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | 195 | 837 | 3.57e-08 |
| GO:BP | GO:2000145 | regulation of cell motility | 169 | 700 | 3.62e-08 |
| GO:BP | GO:0001944 | vasculature development | 140 | 552 | 4.20e-08 |
| GO:BP | GO:0003008 | system process | 250 | 1139 | 4.52e-08 |
| GO:BP | GO:0060047 | heart contraction | 64 | 194 | 8.25e-08 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | 218 | 972 | 9.89e-08 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | 258 | 1193 | 9.89e-08 |
| GO:BP | GO:0040012 | regulation of locomotion | 171 | 720 | 9.89e-08 |
| GO:BP | GO:0030334 | regulation of cell migration | 161 | 668 | 1.01e-07 |
| GO:BP | GO:0003015 | heart process | 66 | 204 | 1.02e-07 |
| GO:BP | GO:0009987 | cellular process | 1718 | 10686 | 1.43e-07 |
| GO:BP | GO:0006793 | phosphorus metabolic process | 381 | 1904 | 1.64e-07 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | 377 | 1883 | 1.90e-07 |
| GO:BP | GO:0035239 | tube morphogenesis | 154 | 638 | 2.01e-07 |
| GO:BP | GO:0023057 | negative regulation of signaling | 228 | 1036 | 2.02e-07 |
| GO:BP | GO:0090257 | regulation of muscle system process | 59 | 177 | 2.08e-07 |
| GO:BP | GO:0048514 | blood vessel morphogenesis | 117 | 450 | 2.21e-07 |
| GO:BP | GO:0014706 | striated muscle tissue development | 67 | 213 | 2.52e-07 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 227 | 1035 | 2.86e-07 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 256 | 1197 | 2.95e-07 |
| GO:BP | GO:0008150 | biological_process | 1789 | 11244 | 2.95e-07 |
| GO:BP | GO:0035295 | tube development | 181 | 787 | 3.49e-07 |
| GO:BP | GO:0006941 | striated muscle contraction | 51 | 146 | 3.97e-07 |
| GO:BP | GO:0045595 | regulation of cell differentiation | 233 | 1073 | 3.97e-07 |
| GO:BP | GO:0010648 | negative regulation of cell communication | 226 | 1034 | 3.97e-07 |
| GO:BP | GO:0055001 | muscle cell development | 55 | 163 | 3.97e-07 |
| GO:BP | GO:0051093 | negative regulation of developmental process | 149 | 622 | 5.42e-07 |
| GO:BP | GO:0001667 | ameboidal-type cell migration | 94 | 344 | 5.59e-07 |
| GO:BP | GO:0141124 | intracellular signaling cassette | 275 | 1314 | 5.84e-07 |
| GO:BP | GO:0030048 | actin filament-based movement | 41 | 107 | 5.84e-07 |
| GO:BP | GO:0060048 | cardiac muscle contraction | 43 | 116 | 7.97e-07 |
| GO:BP | GO:0051094 | positive regulation of developmental process | 202 | 913 | 9.93e-07 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | 84 | 300 | 1.03e-06 |
| GO:BP | GO:0001952 | regulation of cell-matrix adhesion | 36 | 90 | 1.26e-06 |
| GO:BP | GO:0043502 | regulation of muscle adaptation | 30 | 68 | 1.40e-06 |
| GO:BP | GO:0008016 | regulation of heart contraction | 54 | 165 | 1.61e-06 |
| GO:BP | GO:0070252 | actin-mediated cell contraction | 35 | 87 | 1.62e-06 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | 62 | 201 | 1.79e-06 |
| GO:BP | GO:0090130 | tissue migration | 72 | 247 | 1.82e-06 |
| GO:BP | GO:0010631 | epithelial cell migration | 71 | 243 | 2.01e-06 |
| GO:BP | GO:0090132 | epithelium migration | 71 | 243 | 2.01e-06 |
| GO:BP | GO:0065008 | regulation of biological quality | 371 | 1893 | 2.51e-06 |
| GO:BP | GO:0032879 | regulation of localization | 293 | 1439 | 2.57e-06 |
| GO:BP | GO:1903522 | regulation of blood circulation | 60 | 194 | 2.57e-06 |
| GO:BP | GO:0043500 | muscle adaptation | 35 | 89 | 2.96e-06 |
| GO:BP | GO:0035556 | intracellular signal transduction | 380 | 1951 | 3.24e-06 |
| GO:BP | GO:0007507 | heart development | 122 | 499 | 3.38e-06 |
| GO:BP | GO:0007160 | cell-matrix adhesion | 54 | 169 | 3.55e-06 |
| GO:BP | GO:0043542 | endothelial cell migration | 55 | 174 | 4.00e-06 |
| GO:BP | GO:0048468 | cell development | 368 | 1886 | 4.48e-06 |
| GO:BP | GO:0065009 | regulation of molecular function | 267 | 1299 | 4.64e-06 |
| GO:BP | GO:0031032 | actomyosin structure organization | 57 | 184 | 4.89e-06 |
| GO:BP | GO:0051049 | regulation of transport | 231 | 1098 | 5.92e-06 |
| GO:BP | GO:0097435 | supramolecular fiber organization | 146 | 633 | 7.57e-06 |
| GO:BP | GO:0009605 | response to external stimulus | 310 | 1559 | 9.93e-06 |
| GO:BP | GO:0051241 | negative regulation of multicellular organismal process | 159 | 706 | 1.01e-05 |
| GO:BP | GO:0001525 | angiogenesis | 97 | 381 | 1.05e-05 |
| GO:BP | GO:0032409 | regulation of transporter activity | 48 | 148 | 1.09e-05 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 361 | 1862 | 1.17e-05 |
| GO:BP | GO:0055006 | cardiac cell development | 31 | 78 | 1.17e-05 |
| GO:BP | GO:0086001 | cardiac muscle cell action potential | 27 | 63 | 1.18e-05 |
| GO:BP | GO:0007162 | negative regulation of cell adhesion | 56 | 185 | 1.39e-05 |
| GO:BP | GO:0150115 | cell-substrate junction organization | 35 | 95 | 1.68e-05 |
| GO:BP | GO:0055013 | cardiac muscle cell development | 29 | 72 | 2.03e-05 |
| GO:BP | GO:0010959 | regulation of metal ion transport | 67 | 239 | 2.22e-05 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | 217 | 1040 | 2.67e-05 |
| GO:BP | GO:0034330 | cell junction organization | 127 | 545 | 2.67e-05 |
| GO:BP | GO:0055007 | cardiac muscle cell differentiation | 37 | 105 | 2.70e-05 |
| GO:BP | GO:0009611 | response to wounding | 95 | 382 | 4.06e-05 |
| GO:BP | GO:0010243 | response to organonitrogen compound | 152 | 685 | 4.46e-05 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | 222 | 1077 | 4.88e-05 |
| GO:BP | GO:0034762 | regulation of transmembrane transport | 78 | 298 | 4.92e-05 |
| GO:BP | GO:0007010 | cytoskeleton organization | 234 | 1146 | 4.98e-05 |
| GO:BP | GO:0042221 | response to chemical | 430 | 2304 | 5.06e-05 |
| GO:BP | GO:0098657 | import into cell | 140 | 622 | 5.25e-05 |
| GO:BP | GO:0010632 | regulation of epithelial cell migration | 55 | 188 | 5.37e-05 |
| GO:BP | GO:0150116 | regulation of cell-substrate junction organization | 25 | 60 | 5.67e-05 |
| GO:BP | GO:0086003 | cardiac muscle cell contraction | 26 | 64 | 6.13e-05 |
| GO:BP | GO:0009887 | animal organ morphogenesis | 149 | 673 | 6.19e-05 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | 70 | 261 | 6.57e-05 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | 137 | 609 | 6.82e-05 |
| GO:BP | GO:0097553 | calcium ion transmembrane import into cytosol | 40 | 122 | 7.12e-05 |
| GO:BP | GO:0030198 | extracellular matrix organization | 62 | 223 | 7.19e-05 |
| GO:BP | GO:0043269 | regulation of monoatomic ion transport | 74 | 282 | 7.77e-05 |
| GO:BP | GO:0043062 | extracellular structure organization | 62 | 224 | 8.30e-05 |
| GO:BP | GO:0045229 | external encapsulating structure organization | 62 | 224 | 8.30e-05 |
| GO:BP | GO:0061337 | cardiac conduction | 31 | 85 | 8.66e-05 |
| GO:BP | GO:0014902 | myotube differentiation | 31 | 85 | 8.66e-05 |
| GO:BP | GO:0008283 | cell population proliferation | 260 | 1306 | 8.68e-05 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | 107 | 452 | 8.70e-05 |
| GO:BP | GO:0035051 | cardiocyte differentiation | 42 | 132 | 8.87e-05 |
| GO:BP | GO:0002040 | sprouting angiogenesis | 34 | 98 | 9.96e-05 |
| GO:BP | GO:0006936 | muscle contraction | 68 | 255 | 1.06e-04 |
| GO:BP | GO:0051283 | negative regulation of sequestering of calcium ion | 32 | 90 | 1.07e-04 |
| GO:BP | GO:1904062 | regulation of monoatomic cation transmembrane transport | 54 | 188 | 1.10e-04 |
| GO:BP | GO:0009725 | response to hormone | 136 | 610 | 1.12e-04 |
| GO:BP | GO:0007015 | actin filament organization | 88 | 357 | 1.27e-04 |
| GO:BP | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 107 | 456 | 1.28e-04 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | 197 | 951 | 1.28e-04 |
| GO:BP | GO:0030038 | contractile actin filament bundle assembly | 32 | 91 | 1.35e-04 |
| GO:BP | GO:0043149 | stress fiber assembly | 32 | 91 | 1.35e-04 |
| GO:BP | GO:0007517 | muscle organ development | 70 | 267 | 1.37e-04 |
| GO:BP | GO:0042391 | regulation of membrane potential | 73 | 282 | 1.38e-04 |
| GO:BP | GO:0022898 | regulation of transmembrane transporter activity | 43 | 139 | 1.41e-04 |
| GO:BP | GO:0051336 | regulation of hydrolase activity | 102 | 431 | 1.41e-04 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | 66 | 248 | 1.49e-04 |
| GO:BP | GO:1900024 | regulation of substrate adhesion-dependent cell spreading | 22 | 52 | 1.54e-04 |
| GO:BP | GO:0043534 | blood vessel endothelial cell migration | 32 | 92 | 1.67e-04 |
| GO:BP | GO:0051282 | regulation of sequestering of calcium ion | 32 | 92 | 1.67e-04 |
| GO:BP | GO:0034765 | regulation of monoatomic ion transmembrane transport | 58 | 210 | 1.67e-04 |
| GO:BP | GO:0016310 | phosphorylation | 230 | 1145 | 1.71e-04 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | 31 | 88 | 1.73e-04 |
| GO:BP | GO:0071310 | cellular response to organic substance | 256 | 1297 | 1.80e-04 |
| GO:BP | GO:0043270 | positive regulation of monoatomic ion transport | 40 | 127 | 1.80e-04 |
| GO:BP | GO:0010594 | regulation of endothelial cell migration | 42 | 136 | 1.80e-04 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | 131 | 591 | 2.11e-04 |
| GO:BP | GO:0110053 | regulation of actin filament organization | 58 | 212 | 2.19e-04 |
| GO:BP | GO:0051209 | release of sequestered calcium ion into cytosol | 31 | 89 | 2.19e-04 |
| GO:BP | GO:0051899 | membrane depolarization | 23 | 57 | 2.26e-04 |
| GO:BP | GO:0006942 | regulation of striated muscle contraction | 29 | 81 | 2.35e-04 |
| GO:BP | GO:0048041 | focal adhesion assembly | 28 | 77 | 2.40e-04 |
| GO:BP | GO:0006816 | calcium ion transport | 68 | 262 | 2.45e-04 |
| GO:BP | GO:0040013 | negative regulation of locomotion | 64 | 243 | 2.75e-04 |
| GO:BP | GO:0032412 | regulation of monoatomic ion transmembrane transporter activity | 41 | 134 | 2.88e-04 |
| GO:BP | GO:0086065 | cell communication involved in cardiac conduction | 22 | 54 | 2.92e-04 |
| GO:BP | GO:0071559 | response to transforming growth factor beta | 59 | 219 | 2.92e-04 |
| GO:BP | GO:0002028 | regulation of sodium ion transport | 23 | 58 | 3.06e-04 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | 331 | 1751 | 3.13e-04 |
| GO:BP | GO:0070588 | calcium ion transmembrane transport | 57 | 210 | 3.22e-04 |
| GO:BP | GO:0010811 | positive regulation of cell-substrate adhesion | 32 | 95 | 3.23e-04 |
| GO:BP | GO:0071560 | cellular response to transforming growth factor beta stimulus | 58 | 215 | 3.25e-04 |
| GO:BP | GO:0000902 | cell morphogenesis | 152 | 713 | 3.30e-04 |
| GO:BP | GO:0098655 | monoatomic cation transmembrane transport | 112 | 495 | 3.67e-04 |
| GO:BP | GO:1901652 | response to peptide | 88 | 368 | 3.75e-04 |
| GO:BP | GO:0002027 | regulation of heart rate | 29 | 83 | 3.75e-04 |
| GO:BP | GO:0071417 | cellular response to organonitrogen compound | 102 | 442 | 3.80e-04 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | 118 | 528 | 3.80e-04 |
| GO:BP | GO:0090109 | regulation of cell-substrate junction assembly | 22 | 55 | 3.86e-04 |
| GO:BP | GO:0051893 | regulation of focal adhesion assembly | 22 | 55 | 3.86e-04 |
| GO:BP | GO:0051235 | maintenance of location | 65 | 251 | 3.87e-04 |
| GO:BP | GO:0051208 | sequestering of calcium ion | 32 | 96 | 3.90e-04 |
| GO:BP | GO:0098662 | inorganic cation transmembrane transport | 109 | 480 | 3.90e-04 |
| GO:BP | GO:0030335 | positive regulation of cell migration | 93 | 395 | 3.92e-04 |
| GO:BP | GO:0010634 | positive regulation of epithelial cell migration | 39 | 127 | 3.94e-04 |
| GO:BP | GO:0006897 | endocytosis | 111 | 492 | 4.32e-04 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | 218 | 1093 | 4.32e-04 |
| GO:BP | GO:1902305 | regulation of sodium ion transmembrane transport | 17 | 37 | 4.41e-04 |
| GO:BP | GO:0051056 | regulation of small GTPase mediated signal transduction | 61 | 233 | 4.85e-04 |
| GO:BP | GO:2000147 | positive regulation of cell motility | 95 | 408 | 4.92e-04 |
| GO:BP | GO:1901698 | response to nitrogen compound | 155 | 736 | 4.92e-04 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | 75 | 304 | 5.04e-04 |
| GO:BP | GO:0010812 | negative regulation of cell-substrate adhesion | 18 | 41 | 5.16e-04 |
| GO:BP | GO:0086010 | membrane depolarization during action potential | 13 | 24 | 5.16e-04 |
| GO:BP | GO:0046486 | glycerolipid metabolic process | 71 | 284 | 5.24e-04 |
| GO:BP | GO:0001508 | action potential | 33 | 102 | 5.41e-04 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | 99 | 431 | 5.69e-04 |
| GO:BP | GO:0032231 | regulation of actin filament bundle assembly | 29 | 85 | 5.69e-04 |
| GO:BP | GO:0061448 | connective tissue development | 55 | 205 | 5.78e-04 |
| GO:BP | GO:0051492 | regulation of stress fiber assembly | 27 | 77 | 6.23e-04 |
| GO:BP | GO:1903053 | regulation of extracellular matrix organization | 20 | 49 | 6.23e-04 |
| GO:BP | GO:0040017 | positive regulation of locomotion | 96 | 416 | 6.23e-04 |
| GO:BP | GO:0010644 | cell communication by electrical coupling | 15 | 31 | 6.29e-04 |
| GO:BP | GO:0070296 | sarcoplasmic reticulum calcium ion transport | 15 | 31 | 6.29e-04 |
| GO:BP | GO:0051924 | regulation of calcium ion transport | 44 | 153 | 6.33e-04 |
| GO:BP | GO:0006470 | protein dephosphorylation | 49 | 177 | 6.61e-04 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | 99 | 433 | 6.68e-04 |
| GO:BP | GO:0070848 | response to growth factor | 120 | 547 | 6.85e-04 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | 250 | 1289 | 6.88e-04 |
| GO:BP | GO:0051172 | negative regulation of nitrogen compound metabolic process | 308 | 1633 | 6.95e-04 |
| GO:BP | GO:0014808 | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 14 | 28 | 7.29e-04 |
| GO:BP | GO:1903514 | release of sequestered calcium ion into cytosol by endoplasmic reticulum | 14 | 28 | 7.29e-04 |
| GO:BP | GO:0010033 | response to organic substance | 325 | 1736 | 7.30e-04 |
| GO:BP | GO:2000146 | negative regulation of cell motility | 57 | 217 | 7.46e-04 |
| GO:BP | GO:0098660 | inorganic ion transmembrane transport | 115 | 521 | 7.47e-04 |
| GO:BP | GO:0010762 | regulation of fibroblast migration | 16 | 35 | 7.65e-04 |
| GO:BP | GO:0051050 | positive regulation of transport | 124 | 571 | 7.86e-04 |
| GO:BP | GO:0043434 | response to peptide hormone | 76 | 314 | 8.03e-04 |
| GO:BP | GO:0007399 | nervous system development | 331 | 1775 | 8.22e-04 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | 130 | 605 | 8.35e-04 |
| GO:BP | GO:0034446 | substrate adhesion-dependent cell spreading | 29 | 87 | 8.44e-04 |
| GO:BP | GO:0110020 | regulation of actomyosin structure organization | 29 | 87 | 8.44e-04 |
| GO:BP | GO:0006810 | transport | 528 | 2984 | 8.99e-04 |
| GO:BP | GO:0019722 | calcium-mediated signaling | 37 | 123 | 9.22e-04 |
| GO:BP | GO:0001935 | endothelial cell proliferation | 35 | 114 | 9.31e-04 |
| GO:BP | GO:0030001 | metal ion transport | 115 | 524 | 9.31e-04 |
| GO:BP | GO:0016043 | cellular component organization | 815 | 4802 | 1.00e-03 |
| GO:BP | GO:0040007 | growth | 146 | 697 | 1.00e-03 |
| GO:BP | GO:0045785 | positive regulation of cell adhesion | 73 | 301 | 1.03e-03 |
| GO:BP | GO:0051928 | positive regulation of calcium ion transport | 25 | 71 | 1.04e-03 |
| GO:BP | GO:2001257 | regulation of cation channel activity | 24 | 67 | 1.08e-03 |
| GO:BP | GO:0010595 | positive regulation of endothelial cell migration | 29 | 89 | 1.31e-03 |
| GO:BP | GO:1903055 | positive regulation of extracellular matrix organization | 13 | 26 | 1.32e-03 |
| GO:BP | GO:0048384 | retinoic acid receptor signaling pathway | 13 | 26 | 1.32e-03 |
| GO:BP | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 13 | 26 | 1.32e-03 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | 104 | 469 | 1.40e-03 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | 164 | 804 | 1.40e-03 |
| GO:BP | GO:1904064 | positive regulation of cation transmembrane transport | 27 | 81 | 1.49e-03 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | 164 | 805 | 1.49e-03 |
| GO:BP | GO:0006650 | glycerophospholipid metabolic process | 58 | 228 | 1.55e-03 |
| GO:BP | GO:0035791 | platelet-derived growth factor receptor-beta signaling pathway | 9 | 14 | 1.59e-03 |
| GO:BP | GO:0051017 | actin filament bundle assembly | 38 | 131 | 1.64e-03 |
| GO:BP | GO:0044092 | negative regulation of molecular function | 110 | 504 | 1.66e-03 |
| GO:BP | GO:0010649 | regulation of cell communication by electrical coupling | 10 | 17 | 1.71e-03 |
| GO:BP | GO:1902105 | regulation of leukocyte differentiation | 51 | 194 | 1.73e-03 |
| GO:BP | GO:0006468 | protein phosphorylation | 190 | 958 | 1.83e-03 |
| GO:BP | GO:0042060 | wound healing | 70 | 291 | 1.84e-03 |
| GO:BP | GO:0061572 | actin filament bundle organization | 38 | 132 | 1.92e-03 |
| GO:BP | GO:0043010 | camera-type eye development | 58 | 230 | 1.95e-03 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | 105 | 479 | 1.99e-03 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | 171 | 850 | 1.99e-03 |
| GO:BP | GO:0002521 | leukocyte differentiation | 85 | 371 | 2.00e-03 |
| GO:BP | GO:1903844 | regulation of cellular response to transforming growth factor beta stimulus | 36 | 123 | 2.00e-03 |
| GO:BP | GO:1990778 | protein localization to cell periphery | 69 | 287 | 2.06e-03 |
| GO:BP | GO:0007179 | transforming growth factor beta receptor signaling pathway | 46 | 171 | 2.10e-03 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | 282 | 1504 | 2.18e-03 |
| GO:BP | GO:0044093 | positive regulation of molecular function | 159 | 783 | 2.18e-03 |
| GO:BP | GO:0006950 | response to stress | 452 | 2540 | 2.26e-03 |
| GO:BP | GO:0006812 | monoatomic cation transport | 129 | 614 | 2.28e-03 |
| GO:BP | GO:0001954 | positive regulation of cell-matrix adhesion | 17 | 42 | 2.40e-03 |
| GO:BP | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 12 | 24 | 2.40e-03 |
| GO:BP | GO:0002761 | regulation of myeloid leukocyte differentiation | 26 | 79 | 2.41e-03 |
| GO:BP | GO:0016311 | dephosphorylation | 58 | 232 | 2.41e-03 |
| GO:BP | GO:0034220 | monoatomic ion transmembrane transport | 124 | 587 | 2.41e-03 |
| GO:BP | GO:0022008 | neurogenesis | 239 | 1251 | 2.43e-03 |
| GO:BP | GO:0001654 | eye development | 64 | 263 | 2.46e-03 |
| GO:BP | GO:0001501 | skeletal system development | 80 | 347 | 2.48e-03 |
| GO:BP | GO:0002062 | chondrocyte differentiation | 28 | 88 | 2.49e-03 |
| GO:BP | GO:0048660 | regulation of smooth muscle cell proliferation | 30 | 97 | 2.51e-03 |
| GO:BP | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 68 | 284 | 2.51e-03 |
| GO:BP | GO:0006915 | apoptotic process | 260 | 1377 | 2.55e-03 |
| GO:BP | GO:0045655 | regulation of monocyte differentiation | 8 | 12 | 2.66e-03 |
| GO:BP | GO:1900025 | negative regulation of substrate adhesion-dependent cell spreading | 8 | 12 | 2.66e-03 |
| GO:BP | GO:0043535 | regulation of blood vessel endothelial cell migration | 24 | 71 | 2.67e-03 |
| GO:BP | GO:0086012 | membrane depolarization during cardiac muscle cell action potential | 11 | 21 | 2.67e-03 |
| GO:BP | GO:0150063 | visual system development | 64 | 264 | 2.68e-03 |
| GO:BP | GO:0048592 | eye morphogenesis | 32 | 107 | 2.95e-03 |
| GO:BP | GO:1990845 | adaptive thermogenesis | 35 | 121 | 2.98e-03 |
| GO:BP | GO:1905709 | negative regulation of membrane permeability | 9 | 15 | 2.98e-03 |
| GO:BP | GO:0050790 | regulation of catalytic activity | 177 | 893 | 3.06e-03 |
| GO:BP | GO:0051279 | regulation of release of sequestered calcium ion into cytosol | 21 | 59 | 3.09e-03 |
| GO:BP | GO:0051216 | cartilage development | 40 | 145 | 3.10e-03 |
| GO:BP | GO:0006937 | regulation of muscle contraction | 36 | 126 | 3.11e-03 |
| GO:BP | GO:0006629 | lipid metabolic process | 182 | 923 | 3.21e-03 |
| GO:BP | GO:0048880 | sensory system development | 64 | 266 | 3.28e-03 |
| GO:BP | GO:0098609 | cell-cell adhesion | 119 | 564 | 3.28e-03 |
| GO:BP | GO:0051346 | negative regulation of hydrolase activity | 34 | 117 | 3.28e-03 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | 211 | 1093 | 3.29e-03 |
| GO:BP | GO:0060284 | regulation of cell development | 120 | 570 | 3.35e-03 |
| GO:BP | GO:0030336 | negative regulation of cell migration | 53 | 210 | 3.38e-03 |
| GO:BP | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 35 | 122 | 3.43e-03 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | 123 | 588 | 3.64e-03 |
| GO:BP | GO:0048771 | tissue remodeling | 33 | 113 | 3.64e-03 |
| GO:BP | GO:0000768 | syncytium formation by plasma membrane fusion | 15 | 36 | 3.80e-03 |
| GO:BP | GO:0140253 | cell-cell fusion | 15 | 36 | 3.80e-03 |
| GO:BP | GO:0085029 | extracellular matrix assembly | 15 | 36 | 3.80e-03 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | 21 | 60 | 3.85e-03 |
| GO:BP | GO:0007229 | integrin-mediated signaling pathway | 27 | 86 | 3.85e-03 |
| GO:BP | GO:0035725 | sodium ion transmembrane transport | 29 | 95 | 3.85e-03 |
| GO:BP | GO:0051179 | localization | 639 | 3731 | 4.07e-03 |
| GO:BP | GO:0033002 | muscle cell proliferation | 41 | 152 | 4.11e-03 |
| GO:BP | GO:0030097 | hemopoiesis | 129 | 624 | 4.12e-03 |
| GO:BP | GO:0051234 | establishment of localization | 561 | 3240 | 4.12e-03 |
| GO:BP | GO:0086002 | cardiac muscle cell action potential involved in contraction | 17 | 44 | 4.12e-03 |
| GO:BP | GO:0050673 | epithelial cell proliferation | 70 | 300 | 4.12e-03 |
| GO:BP | GO:0034767 | positive regulation of monoatomic ion transmembrane transport | 28 | 91 | 4.20e-03 |
| GO:BP | GO:0007520 | myoblast fusion | 13 | 29 | 4.22e-03 |
| GO:BP | GO:2000649 | regulation of sodium ion transmembrane transporter activity | 13 | 29 | 4.22e-03 |
| GO:BP | GO:0150117 | positive regulation of cell-substrate junction organization | 13 | 29 | 4.22e-03 |
| GO:BP | GO:0036293 | response to decreased oxygen levels | 59 | 243 | 4.25e-03 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | 159 | 796 | 4.26e-03 |
| GO:BP | GO:0010647 | positive regulation of cell communication | 231 | 1218 | 4.41e-03 |
| GO:BP | GO:0048593 | camera-type eye morphogenesis | 27 | 87 | 4.57e-03 |
| GO:BP | GO:0002376 | immune system process | 263 | 1410 | 4.67e-03 |
| GO:BP | GO:0022604 | regulation of cell morphogenesis | 49 | 193 | 4.76e-03 |
| GO:BP | GO:0061614 | miRNA transcription | 21 | 61 | 4.76e-03 |
| GO:BP | GO:0070482 | response to oxygen levels | 63 | 265 | 4.78e-03 |
| GO:BP | GO:0042592 | homeostatic process | 217 | 1137 | 4.78e-03 |
| GO:BP | GO:0014897 | striated muscle hypertrophy | 24 | 74 | 4.80e-03 |
| GO:BP | GO:0048659 | smooth muscle cell proliferation | 30 | 101 | 4.80e-03 |
| GO:BP | GO:1901184 | regulation of ERBB signaling pathway | 20 | 57 | 4.95e-03 |
| GO:BP | GO:0023056 | positive regulation of signaling | 231 | 1221 | 4.99e-03 |
| GO:BP | GO:0014874 | response to stimulus involved in regulation of muscle adaptation | 8 | 13 | 5.08e-03 |
| GO:BP | GO:0008360 | regulation of cell shape | 31 | 106 | 5.08e-03 |
| GO:BP | GO:0086064 | cell communication by electrical coupling involved in cardiac conduction | 12 | 26 | 5.14e-03 |
| GO:BP | GO:0012501 | programmed cell death | 264 | 1419 | 5.20e-03 |
| GO:BP | GO:0008610 | lipid biosynthetic process | 111 | 527 | 5.24e-03 |
| GO:BP | GO:0045765 | regulation of angiogenesis | 49 | 194 | 5.25e-03 |
| GO:BP | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 17 | 45 | 5.25e-03 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | 376 | 2100 | 5.37e-03 |
| GO:BP | GO:0030030 | cell projection organization | 224 | 1182 | 5.54e-03 |
| GO:BP | GO:0007264 | small GTPase-mediated signal transduction | 86 | 390 | 5.64e-03 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | 90 | 412 | 5.70e-03 |
| GO:BP | GO:0014896 | muscle hypertrophy | 24 | 75 | 5.80e-03 |
| GO:BP | GO:0071375 | cellular response to peptide hormone stimulus | 56 | 231 | 5.97e-03 |
| GO:BP | GO:1903706 | regulation of hemopoiesis | 61 | 257 | 5.97e-03 |
| GO:BP | GO:0008219 | cell death | 264 | 1423 | 6.07e-03 |
| GO:BP | GO:1901653 | cellular response to peptide | 64 | 273 | 6.11e-03 |
| GO:BP | GO:0030224 | monocyte differentiation | 11 | 23 | 6.15e-03 |
| GO:BP | GO:1902894 | negative regulation of miRNA transcription | 11 | 23 | 6.15e-03 |
| GO:BP | GO:0006644 | phospholipid metabolic process | 67 | 289 | 6.15e-03 |
| GO:BP | GO:0002026 | regulation of the force of heart contraction | 11 | 23 | 6.15e-03 |
| GO:BP | GO:0009790 | embryo development | 162 | 821 | 6.25e-03 |
| GO:BP | GO:1901019 | regulation of calcium ion transmembrane transporter activity | 18 | 50 | 6.67e-03 |
| GO:BP | GO:0051651 | maintenance of location in cell | 44 | 171 | 6.68e-03 |
| GO:BP | GO:0045668 | negative regulation of osteoblast differentiation | 15 | 38 | 6.69e-03 |
| GO:BP | GO:0006949 | syncytium formation | 15 | 38 | 6.69e-03 |
| GO:BP | GO:0035265 | organ growth | 35 | 127 | 6.82e-03 |
| GO:BP | GO:1903169 | regulation of calcium ion transmembrane transport | 31 | 108 | 6.83e-03 |
| GO:BP | GO:0014894 | response to denervation involved in regulation of muscle adaptation | 6 | 8 | 6.83e-03 |
| GO:BP | GO:0014877 | response to muscle inactivity involved in regulation of muscle adaptation | 6 | 8 | 6.83e-03 |
| GO:BP | GO:0006811 | monoatomic ion transport | 144 | 719 | 6.85e-03 |
| GO:BP | GO:0016192 | vesicle-mediated transport | 218 | 1152 | 6.92e-03 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | 459 | 2622 | 7.03e-03 |
| GO:BP | GO:0032411 | positive regulation of transporter activity | 21 | 63 | 7.08e-03 |
| GO:BP | GO:0001558 | regulation of cell growth | 73 | 323 | 7.21e-03 |
| GO:BP | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process | 10 | 20 | 7.22e-03 |
| GO:BP | GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 12 | 27 | 7.25e-03 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | 115 | 555 | 7.26e-03 |
| GO:BP | GO:0038127 | ERBB signaling pathway | 30 | 104 | 7.53e-03 |
| GO:BP | GO:0048878 | chemical homeostasis | 135 | 670 | 7.93e-03 |
| GO:BP | GO:0090559 | regulation of membrane permeability | 19 | 55 | 7.98e-03 |
| GO:BP | GO:1901342 | regulation of vasculature development | 49 | 198 | 7.98e-03 |
| GO:BP | GO:0008154 | actin polymerization or depolymerization | 39 | 148 | 8.26e-03 |
| GO:BP | GO:0090596 | sensory organ morphogenesis | 44 | 173 | 8.32e-03 |
| GO:BP | GO:0019637 | organophosphate metabolic process | 152 | 769 | 8.41e-03 |
| GO:BP | GO:0040008 | regulation of growth | 98 | 462 | 8.42e-03 |
| GO:BP | GO:0014743 | regulation of muscle hypertrophy | 17 | 47 | 8.62e-03 |
| GO:BP | GO:0030010 | establishment of cell polarity | 34 | 124 | 8.68e-03 |
| GO:BP | GO:0003300 | cardiac muscle hypertrophy | 23 | 73 | 9.07e-03 |
| GO:BP | GO:0048661 | positive regulation of smooth muscle cell proliferation | 20 | 60 | 9.37e-03 |
| GO:BP | GO:0001936 | regulation of endothelial cell proliferation | 28 | 96 | 9.37e-03 |
| GO:BP | GO:1903708 | positive regulation of hemopoiesis | 32 | 115 | 9.45e-03 |
| GO:BP | GO:1902107 | positive regulation of leukocyte differentiation | 32 | 115 | 9.45e-03 |
| GO:BP | GO:0098771 | inorganic ion homeostasis | 77 | 348 | 9.45e-03 |
| GO:BP | GO:1990849 | vacuolar localization | 19 | 56 | 9.96e-03 |
| GO:BP | GO:0032418 | lysosome localization | 19 | 56 | 9.96e-03 |
| GO:BP | GO:1902904 | negative regulation of supramolecular fiber organization | 34 | 125 | 9.96e-03 |
| GO:BP | GO:0034764 | positive regulation of transmembrane transport | 35 | 130 | 1.02e-02 |
| GO:BP | GO:1903670 | regulation of sprouting angiogenesis | 12 | 28 | 1.03e-02 |
| GO:BP | GO:0055074 | calcium ion homeostasis | 52 | 216 | 1.04e-02 |
| GO:BP | GO:1904427 | positive regulation of calcium ion transmembrane transport | 18 | 52 | 1.05e-02 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | 216 | 1150 | 1.05e-02 |
| GO:BP | GO:0055117 | regulation of cardiac muscle contraction | 21 | 65 | 1.06e-02 |
| GO:BP | GO:0001666 | response to hypoxia | 55 | 232 | 1.07e-02 |
| GO:BP | GO:0009991 | response to extracellular stimulus | 82 | 377 | 1.07e-02 |
| GO:BP | GO:0045834 | positive regulation of lipid metabolic process | 25 | 83 | 1.07e-02 |
| GO:BP | GO:0032787 | monocarboxylic acid metabolic process | 89 | 416 | 1.10e-02 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 829 | 4988 | 1.13e-02 |
| GO:BP | GO:0044255 | cellular lipid metabolic process | 138 | 694 | 1.13e-02 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | 60 | 259 | 1.13e-02 |
| GO:BP | GO:0003254 | regulation of membrane depolarization | 14 | 36 | 1.13e-02 |
| GO:BP | GO:0072659 | protein localization to plasma membrane | 56 | 238 | 1.14e-02 |
| GO:BP | GO:0045165 | cell fate commitment | 39 | 151 | 1.18e-02 |
| GO:BP | GO:0003205 | cardiac chamber development | 39 | 151 | 1.18e-02 |
| GO:BP | GO:0048589 | developmental growth | 104 | 501 | 1.18e-02 |
| GO:BP | GO:0007267 | cell-cell signaling | 204 | 1082 | 1.20e-02 |
| GO:BP | GO:0106106 | cold-induced thermogenesis | 31 | 112 | 1.21e-02 |
| GO:BP | GO:1903589 | positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis | 4 | 4 | 1.22e-02 |
| GO:BP | GO:0008064 | regulation of actin polymerization or depolymerization | 32 | 117 | 1.24e-02 |
| GO:BP | GO:0051494 | negative regulation of cytoskeleton organization | 34 | 127 | 1.29e-02 |
| GO:BP | GO:2000629 | negative regulation of miRNA metabolic process | 11 | 25 | 1.29e-02 |
| GO:BP | GO:0006658 | phosphatidylserine metabolic process | 9 | 18 | 1.29e-02 |
| GO:BP | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis | 9 | 18 | 1.29e-02 |
| GO:BP | GO:0060402 | calcium ion transport into cytosol | 9 | 18 | 1.29e-02 |
| GO:BP | GO:0043304 | regulation of mast cell degranulation | 9 | 18 | 1.29e-02 |
| GO:BP | GO:0010743 | regulation of macrophage derived foam cell differentiation | 9 | 18 | 1.29e-02 |
| GO:BP | GO:0006814 | sodium ion transport | 36 | 137 | 1.30e-02 |
| GO:BP | GO:0042981 | regulation of apoptotic process | 195 | 1031 | 1.31e-02 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | 347 | 1951 | 1.34e-02 |
| GO:BP | GO:0032233 | positive regulation of actin filament bundle assembly | 17 | 49 | 1.35e-02 |
| GO:BP | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 24 | 80 | 1.37e-02 |
| GO:BP | GO:0086005 | ventricular cardiac muscle cell action potential | 12 | 29 | 1.39e-02 |
| GO:BP | GO:0006096 | glycolytic process | 22 | 71 | 1.39e-02 |
| GO:BP | GO:0031324 | negative regulation of cellular metabolic process | 344 | 1934 | 1.39e-02 |
| GO:BP | GO:0030832 | regulation of actin filament length | 32 | 118 | 1.40e-02 |
| GO:BP | GO:0031667 | response to nutrient levels | 77 | 354 | 1.45e-02 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | 63 | 278 | 1.45e-02 |
| GO:BP | GO:0006909 | phagocytosis | 36 | 138 | 1.46e-02 |
| GO:BP | GO:0032414 | positive regulation of ion transmembrane transporter activity | 19 | 58 | 1.47e-02 |
| GO:BP | GO:0010563 | negative regulation of phosphorus metabolic process | 65 | 289 | 1.47e-02 |
| GO:BP | GO:0016049 | cell growth | 82 | 382 | 1.48e-02 |
| GO:BP | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 6 | 9 | 1.48e-02 |
| GO:BP | GO:0014745 | negative regulation of muscle adaptation | 6 | 9 | 1.48e-02 |
| GO:BP | GO:0043306 | positive regulation of mast cell degranulation | 6 | 9 | 1.48e-02 |
| GO:BP | GO:0014870 | response to muscle inactivity | 6 | 9 | 1.48e-02 |
| GO:BP | GO:0019222 | regulation of metabolic process | 767 | 4603 | 1.52e-02 |
| GO:BP | GO:0007266 | Rho protein signal transduction | 30 | 109 | 1.52e-02 |
| GO:BP | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 50 | 210 | 1.54e-02 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | 288 | 1595 | 1.55e-02 |
| GO:BP | GO:0071871 | response to epinephrine | 7 | 12 | 1.56e-02 |
| GO:BP | GO:0034329 | cell junction assembly | 71 | 323 | 1.64e-02 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | 22 | 72 | 1.65e-02 |
| GO:BP | GO:0010761 | fibroblast migration | 17 | 50 | 1.67e-02 |
| GO:BP | GO:0048008 | platelet-derived growth factor receptor signaling pathway | 17 | 50 | 1.67e-02 |
| GO:BP | GO:0001775 | cell activation | 125 | 627 | 1.67e-02 |
| GO:BP | GO:0009179 | purine ribonucleoside diphosphate metabolic process | 25 | 86 | 1.68e-02 |
| GO:BP | GO:0009135 | purine nucleoside diphosphate metabolic process | 25 | 86 | 1.68e-02 |
| GO:BP | GO:0007173 | epidermal growth factor receptor signaling pathway | 25 | 86 | 1.68e-02 |
| GO:BP | GO:1905952 | regulation of lipid localization | 30 | 110 | 1.74e-02 |
| GO:BP | GO:0046902 | regulation of mitochondrial membrane permeability | 16 | 46 | 1.75e-02 |
| GO:BP | GO:0050654 | chondroitin sulfate proteoglycan metabolic process | 11 | 26 | 1.75e-02 |
| GO:BP | GO:0071407 | cellular response to organic cyclic compound | 81 | 379 | 1.75e-02 |
| GO:BP | GO:0010611 | regulation of cardiac muscle hypertrophy | 16 | 46 | 1.75e-02 |
| GO:BP | GO:0045637 | regulation of myeloid cell differentiation | 35 | 135 | 1.82e-02 |
| GO:BP | GO:0031529 | ruffle organization | 15 | 42 | 1.82e-02 |
| GO:BP | GO:0060627 | regulation of vesicle-mediated transport | 80 | 374 | 1.82e-02 |
| GO:BP | GO:0086009 | membrane repolarization | 15 | 42 | 1.82e-02 |
| GO:BP | GO:0030099 | myeloid cell differentiation | 65 | 292 | 1.83e-02 |
| GO:BP | GO:0001974 | blood vessel remodeling | 12 | 30 | 1.85e-02 |
| GO:BP | GO:0098900 | regulation of action potential | 14 | 38 | 1.87e-02 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | 147 | 757 | 1.87e-02 |
| GO:BP | GO:0010662 | regulation of striated muscle cell apoptotic process | 13 | 34 | 1.88e-02 |
| GO:BP | GO:1901201 | regulation of extracellular matrix assembly | 9 | 19 | 1.90e-02 |
| GO:BP | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion | 9 | 19 | 1.90e-02 |
| GO:BP | GO:0006874 | intracellular calcium ion homeostasis | 48 | 202 | 1.91e-02 |
| GO:BP | GO:0045017 | glycerolipid biosynthetic process | 48 | 202 | 1.91e-02 |
| GO:BP | GO:0046032 | ADP catabolic process | 22 | 73 | 1.91e-02 |
| GO:BP | GO:0120161 | regulation of cold-induced thermogenesis | 30 | 111 | 1.95e-02 |
| GO:BP | GO:0009628 | response to abiotic stimulus | 156 | 811 | 1.98e-02 |
| GO:BP | GO:0042325 | regulation of phosphorylation | 134 | 683 | 2.02e-02 |
| GO:BP | GO:0043067 | regulation of programmed cell death | 198 | 1060 | 2.02e-02 |
| GO:BP | GO:0045936 | negative regulation of phosphate metabolic process | 64 | 288 | 2.03e-02 |
| GO:BP | GO:0007423 | sensory organ development | 82 | 387 | 2.04e-02 |
| GO:BP | GO:0046031 | ADP metabolic process | 23 | 78 | 2.04e-02 |
| GO:BP | GO:0120162 | positive regulation of cold-induced thermogenesis | 21 | 69 | 2.11e-02 |
| GO:BP | GO:0014909 | smooth muscle cell migration | 19 | 60 | 2.11e-02 |
| GO:BP | GO:0030833 | regulation of actin filament polymerization | 28 | 102 | 2.15e-02 |
| GO:BP | GO:0034763 | negative regulation of transmembrane transport | 24 | 83 | 2.15e-02 |
| GO:BP | GO:0003416 | endochondral bone growth | 10 | 23 | 2.19e-02 |
| GO:BP | GO:0010765 | positive regulation of sodium ion transport | 10 | 23 | 2.19e-02 |
| GO:BP | GO:0030162 | regulation of proteolysis | 87 | 416 | 2.19e-02 |
| GO:BP | GO:0002573 | myeloid leukocyte differentiation | 38 | 152 | 2.24e-02 |
| GO:BP | GO:0019725 | cellular homeostasis | 113 | 564 | 2.25e-02 |
| GO:BP | GO:0051496 | positive regulation of stress fiber assembly | 15 | 43 | 2.27e-02 |
| GO:BP | GO:0032272 | negative regulation of protein polymerization | 20 | 65 | 2.31e-02 |
| GO:BP | GO:0035023 | regulation of Rho protein signal transduction | 20 | 65 | 2.31e-02 |
| GO:BP | GO:0048699 | generation of neurons | 200 | 1076 | 2.36e-02 |
| GO:BP | GO:0062012 | regulation of small molecule metabolic process | 53 | 231 | 2.42e-02 |
| GO:BP | GO:0045657 | positive regulation of monocyte differentiation | 5 | 7 | 2.49e-02 |
| GO:BP | GO:0002064 | epithelial cell development | 37 | 148 | 2.54e-02 |
| GO:BP | GO:0031399 | regulation of protein modification process | 172 | 911 | 2.54e-02 |
| GO:BP | GO:0007584 | response to nutrient | 30 | 113 | 2.54e-02 |
| GO:BP | GO:1905475 | regulation of protein localization to membrane | 36 | 143 | 2.54e-02 |
| GO:BP | GO:1902905 | positive regulation of supramolecular fiber organization | 35 | 138 | 2.56e-02 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | 181 | 965 | 2.59e-02 |
| GO:BP | GO:0035795 | negative regulation of mitochondrial membrane permeability | 7 | 13 | 2.61e-02 |
| GO:BP | GO:0043066 | negative regulation of apoptotic process | 122 | 619 | 2.65e-02 |
| GO:BP | GO:0009137 | purine nucleoside diphosphate catabolic process | 22 | 75 | 2.65e-02 |
| GO:BP | GO:0019364 | pyridine nucleotide catabolic process | 22 | 75 | 2.65e-02 |
| GO:BP | GO:0009181 | purine ribonucleoside diphosphate catabolic process | 22 | 75 | 2.65e-02 |
| GO:BP | GO:0006082 | organic acid metabolic process | 123 | 625 | 2.68e-02 |
| GO:BP | GO:0071872 | cellular response to epinephrine stimulus | 6 | 10 | 2.76e-02 |
| GO:BP | GO:0032530 | regulation of microvillus organization | 6 | 10 | 2.76e-02 |
| GO:BP | GO:0033275 | actin-myosin filament sliding | 6 | 10 | 2.76e-02 |
| GO:BP | GO:0060314 | regulation of ryanodine-sensitive calcium-release channel activity | 9 | 20 | 2.76e-02 |
| GO:BP | GO:1903671 | negative regulation of sprouting angiogenesis | 6 | 10 | 2.76e-02 |
| GO:BP | GO:0031099 | regeneration | 36 | 144 | 2.81e-02 |
| GO:BP | GO:0070613 | regulation of protein processing | 15 | 44 | 2.81e-02 |
| GO:BP | GO:0050678 | regulation of epithelial cell proliferation | 56 | 249 | 2.81e-02 |
| GO:BP | GO:0002042 | cell migration involved in sprouting angiogenesis | 15 | 44 | 2.81e-02 |
| GO:BP | GO:0010876 | lipid localization | 65 | 298 | 2.82e-02 |
| GO:BP | GO:0043086 | negative regulation of catalytic activity | 65 | 298 | 2.82e-02 |
| GO:BP | GO:0030041 | actin filament polymerization | 32 | 124 | 2.84e-02 |
| GO:BP | GO:0043409 | negative regulation of MAPK cascade | 32 | 124 | 2.84e-02 |
| GO:BP | GO:0007519 | skeletal muscle tissue development | 31 | 119 | 2.84e-02 |
| GO:BP | GO:0010717 | regulation of epithelial to mesenchymal transition | 24 | 85 | 2.86e-02 |
| GO:BP | GO:0032271 | regulation of protein polymerization | 39 | 160 | 3.00e-02 |
| GO:BP | GO:0045923 | positive regulation of fatty acid metabolic process | 10 | 24 | 3.01e-02 |
| GO:BP | GO:0098868 | bone growth | 10 | 24 | 3.01e-02 |
| GO:BP | GO:0002763 | positive regulation of myeloid leukocyte differentiation | 13 | 36 | 3.06e-02 |
| GO:BP | GO:0048662 | negative regulation of smooth muscle cell proliferation | 13 | 36 | 3.06e-02 |
| GO:BP | GO:2001259 | positive regulation of cation channel activity | 13 | 36 | 3.06e-02 |
| GO:BP | GO:0006869 | lipid transport | 58 | 261 | 3.06e-02 |
| GO:BP | GO:0060429 | epithelium development | 151 | 792 | 3.09e-02 |
| GO:BP | GO:0050878 | regulation of body fluid levels | 52 | 229 | 3.15e-02 |
| GO:BP | GO:0003206 | cardiac chamber morphogenesis | 29 | 110 | 3.17e-02 |
| GO:BP | GO:0071805 | potassium ion transmembrane transport | 31 | 120 | 3.20e-02 |
| GO:BP | GO:1904705 | regulation of vascular associated smooth muscle cell proliferation | 16 | 49 | 3.21e-02 |
| GO:BP | GO:0022407 | regulation of cell-cell adhesion | 61 | 278 | 3.23e-02 |
| GO:BP | GO:0014070 | response to organic cyclic compound | 119 | 606 | 3.24e-02 |
| GO:BP | GO:0019752 | carboxylic acid metabolic process | 119 | 606 | 3.24e-02 |
| GO:BP | GO:0048844 | artery morphogenesis | 18 | 58 | 3.27e-02 |
| GO:BP | GO:0010955 | negative regulation of protein processing | 8 | 17 | 3.34e-02 |
| GO:BP | GO:0030206 | chondroitin sulfate biosynthetic process | 8 | 17 | 3.34e-02 |
| GO:BP | GO:1903318 | negative regulation of protein maturation | 8 | 17 | 3.34e-02 |
| GO:BP | GO:0034383 | low-density lipoprotein particle clearance | 8 | 17 | 3.34e-02 |
| GO:BP | GO:0006090 | pyruvate metabolic process | 25 | 91 | 3.38e-02 |
| GO:BP | GO:0055080 | monoatomic cation homeostasis | 83 | 401 | 3.41e-02 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | 125 | 642 | 3.41e-02 |
| GO:BP | GO:0048667 | cell morphogenesis involved in neuron differentiation | 89 | 435 | 3.42e-02 |
| GO:BP | GO:0009185 | ribonucleoside diphosphate metabolic process | 26 | 96 | 3.44e-02 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | 181 | 973 | 3.47e-02 |
| GO:BP | GO:0097191 | extrinsic apoptotic signaling pathway | 41 | 172 | 3.47e-02 |
| GO:BP | GO:0051258 | protein polymerization | 51 | 225 | 3.48e-02 |
| GO:BP | GO:0009132 | nucleoside diphosphate metabolic process | 27 | 101 | 3.48e-02 |
| GO:BP | GO:0002262 | myeloid cell homeostasis | 34 | 136 | 3.48e-02 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | 669 | 4015 | 3.51e-02 |
| GO:BP | GO:0014910 | regulation of smooth muscle cell migration | 17 | 54 | 3.53e-02 |
| GO:BP | GO:0090101 | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 30 | 116 | 3.54e-02 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | 43 | 183 | 3.63e-02 |
| GO:BP | GO:0031638 | zymogen activation | 14 | 41 | 3.63e-02 |
| GO:BP | GO:0055085 | transmembrane transport | 172 | 921 | 3.69e-02 |
| GO:BP | GO:0045216 | cell-cell junction organization | 37 | 152 | 3.72e-02 |
| GO:BP | GO:0019915 | lipid storage | 20 | 68 | 3.72e-02 |
| GO:BP | GO:0055002 | striated muscle cell development | 20 | 68 | 3.72e-02 |
| GO:BP | GO:0043436 | oxoacid metabolic process | 121 | 621 | 3.78e-02 |
| GO:BP | GO:0010658 | striated muscle cell apoptotic process | 13 | 37 | 3.81e-02 |
| GO:BP | GO:1903115 | regulation of actin filament-based movement | 13 | 37 | 3.81e-02 |
| GO:BP | GO:0010660 | regulation of muscle cell apoptotic process | 16 | 50 | 3.82e-02 |
| GO:BP | GO:0015918 | sterol transport | 25 | 92 | 3.82e-02 |
| GO:BP | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 16 | 50 | 3.82e-02 |
| GO:BP | GO:0035914 | skeletal muscle cell differentiation | 16 | 50 | 3.82e-02 |
| GO:BP | GO:1904259 | regulation of basement membrane assembly involved in embryonic body morphogenesis | 4 | 5 | 3.83e-02 |
| GO:BP | GO:1904261 | positive regulation of basement membrane assembly involved in embryonic body morphogenesis | 4 | 5 | 3.83e-02 |
| GO:BP | GO:2001197 | basement membrane assembly involved in embryonic body morphogenesis | 4 | 5 | 3.83e-02 |
| GO:BP | GO:2000669 | negative regulation of dendritic cell apoptotic process | 4 | 5 | 3.83e-02 |
| GO:BP | GO:1904978 | regulation of endosome organization | 4 | 5 | 3.83e-02 |
| GO:BP | GO:0021960 | anterior commissure morphogenesis | 4 | 5 | 3.83e-02 |
| GO:BP | GO:0046898 | response to cycloheximide | 4 | 5 | 3.83e-02 |
| GO:BP | GO:1902267 | regulation of polyamine transmembrane transport | 4 | 5 | 3.83e-02 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | 94 | 466 | 3.85e-02 |
| GO:BP | GO:0006790 | sulfur compound metabolic process | 52 | 232 | 3.88e-02 |
| GO:BP | GO:0010927 | cellular component assembly involved in morphogenesis | 28 | 107 | 3.89e-02 |
| GO:BP | GO:0032232 | negative regulation of actin filament bundle assembly | 10 | 25 | 3.90e-02 |
| GO:BP | GO:1901203 | positive regulation of extracellular matrix assembly | 7 | 14 | 3.90e-02 |
| GO:BP | GO:0060142 | regulation of syncytium formation by plasma membrane fusion | 7 | 14 | 3.90e-02 |
| GO:BP | GO:1904738 | vascular associated smooth muscle cell migration | 10 | 25 | 3.90e-02 |
| GO:BP | GO:0048762 | mesenchymal cell differentiation | 46 | 200 | 3.90e-02 |
| GO:BP | GO:0031325 | positive regulation of cellular metabolic process | 402 | 2333 | 3.95e-02 |
| GO:BP | GO:0072526 | pyridine-containing compound catabolic process | 22 | 78 | 3.96e-02 |
| GO:BP | GO:0009191 | ribonucleoside diphosphate catabolic process | 22 | 78 | 3.96e-02 |
| GO:BP | GO:0055017 | cardiac muscle tissue growth | 19 | 64 | 4.01e-02 |
| GO:BP | GO:1904036 | negative regulation of epithelial cell apoptotic process | 15 | 46 | 4.05e-02 |
| GO:BP | GO:0030182 | neuron differentiation | 187 | 1014 | 4.07e-02 |
| GO:BP | GO:0010657 | muscle cell apoptotic process | 17 | 55 | 4.12e-02 |
| GO:BP | GO:0048598 | embryonic morphogenesis | 86 | 422 | 4.17e-02 |
| GO:BP | GO:0051173 | positive regulation of nitrogen compound metabolic process | 378 | 2186 | 4.24e-02 |
| GO:BP | GO:0030855 | epithelial cell differentiation | 87 | 428 | 4.25e-02 |
| GO:BP | GO:0060538 | skeletal muscle organ development | 32 | 128 | 4.29e-02 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | 124 | 642 | 4.34e-02 |
| GO:BP | GO:0042326 | negative regulation of phosphorylation | 53 | 239 | 4.36e-02 |
| GO:BP | GO:0022408 | negative regulation of cell-cell adhesion | 29 | 113 | 4.36e-02 |
| GO:BP | GO:1905954 | positive regulation of lipid localization | 21 | 74 | 4.42e-02 |
| GO:BP | GO:0050801 | monoatomic ion homeostasis | 83 | 406 | 4.42e-02 |
| GO:BP | GO:0014854 | response to inactivity | 6 | 11 | 4.46e-02 |
| GO:BP | GO:0014733 | regulation of skeletal muscle adaptation | 6 | 11 | 4.46e-02 |
| GO:BP | GO:1901739 | regulation of myoblast fusion | 6 | 11 | 4.46e-02 |
| GO:BP | GO:0010172 | embryonic body morphogenesis | 6 | 11 | 4.46e-02 |
| GO:BP | GO:0021783 | preganglionic parasympathetic fiber development | 6 | 11 | 4.46e-02 |
| GO:BP | GO:1990874 | vascular associated smooth muscle cell proliferation | 16 | 51 | 4.47e-02 |
| GO:BP | GO:0042058 | regulation of epidermal growth factor receptor signaling pathway | 16 | 51 | 4.47e-02 |
| GO:BP | GO:0030278 | regulation of ossification | 22 | 79 | 4.54e-02 |
| GO:BP | GO:0048666 | neuron development | 157 | 838 | 4.56e-02 |
| GO:BP | GO:0010639 | negative regulation of organelle organization | 62 | 289 | 4.56e-02 |
| GO:BP | GO:1901028 | regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway | 8 | 18 | 4.61e-02 |
| GO:BP | GO:0055093 | response to hyperoxia | 8 | 18 | 4.61e-02 |
| GO:BP | GO:2000586 | regulation of platelet-derived growth factor receptor-beta signaling pathway | 5 | 8 | 4.66e-02 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 414 | 2415 | 4.66e-02 |
| GO:BP | GO:0045861 | negative regulation of proteolysis | 32 | 129 | 4.73e-02 |
| GO:BP | GO:0001933 | negative regulation of protein phosphorylation | 50 | 224 | 4.76e-02 |
| GO:BP | GO:0046434 | organophosphate catabolic process | 41 | 176 | 4.81e-02 |
| GO:BP | GO:0048639 | positive regulation of developmental growth | 30 | 119 | 4.81e-02 |
| GO:BP | GO:0062013 | positive regulation of small molecule metabolic process | 26 | 99 | 4.83e-02 |
| GO:BP | GO:0045766 | positive regulation of angiogenesis | 29 | 114 | 4.83e-02 |
| GO:BP | GO:0003229 | ventricular cardiac muscle tissue development | 17 | 56 | 4.83e-02 |
| GO:BP | GO:0002067 | glandular epithelial cell differentiation | 15 | 47 | 4.83e-02 |
| GO:BP | GO:0097006 | regulation of plasma lipoprotein particle levels | 15 | 47 | 4.83e-02 |
| GO:BP | GO:1903317 | regulation of protein maturation | 15 | 47 | 4.83e-02 |
| GO:BP | GO:0001938 | positive regulation of endothelial cell proliferation | 20 | 70 | 4.84e-02 |
| GO:BP | GO:0043085 | positive regulation of catalytic activity | 107 | 546 | 4.91e-02 |
| GO:BP | GO:0001945 | lymph vessel development | 9 | 22 | 4.91e-02 |
| GO:BP | GO:1900027 | regulation of ruffle assembly | 9 | 22 | 4.91e-02 |
| GO:BP | GO:1903779 | regulation of cardiac conduction | 9 | 22 | 4.91e-02 |
| GO:BP | GO:0030279 | negative regulation of ossification | 9 | 22 | 4.91e-02 |
| GO:BP | GO:0033688 | regulation of osteoblast proliferation | 9 | 22 | 4.91e-02 |
| GO:BP | GO:0051497 | negative regulation of stress fiber assembly | 9 | 22 | 4.91e-02 |
| GO:BP | GO:0051495 | positive regulation of cytoskeleton organization | 35 | 145 | 4.92e-02 |
| GO:BP | GO:0032373 | positive regulation of sterol transport | 11 | 30 | 4.94e-02 |
| GO:BP | GO:0032376 | positive regulation of cholesterol transport | 11 | 30 | 4.94e-02 |
| GO:BP | GO:0043087 | regulation of GTPase activity | 39 | 166 | 4.96e-02 |
| GO:BP | GO:1904035 | regulation of epithelial cell apoptotic process | 21 | 75 | 4.96e-02 |
| GO:BP | GO:0090288 | negative regulation of cellular response to growth factor stimulus | 21 | 75 | 4.96e-02 |
LRnomtable_20k_enh %>%
filter(source=="KEGG", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in LR enhancer neargenes_20k") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | 43 | 124 | 2.31e-05 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | 32 | 82 | 2.50e-05 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | 30 | 77 | 4.24e-05 |
| KEGG | KEGG:03320 | PPAR signaling pathway | 21 | 47 | 1.29e-04 |
| KEGG | KEGG:04510 | Focal adhesion | 48 | 169 | 4.37e-04 |
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | 25 | 67 | 4.37e-04 |
| KEGG | KEGG:04925 | Aldosterone synthesis and secretion | 27 | 75 | 4.37e-04 |
| KEGG | KEGG:04971 | Gastric acid secretion | 20 | 51 | 1.23e-03 |
| KEGG | KEGG:05165 | Human papillomavirus infection | 63 | 252 | 1.35e-03 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 26 | 78 | 1.74e-03 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | 62 | 250 | 1.74e-03 |
| KEGG | KEGG:05200 | Pathways in cancer | 88 | 391 | 2.40e-03 |
| KEGG | KEGG:04260 | Cardiac muscle contraction | 22 | 63 | 2.47e-03 |
| KEGG | KEGG:04371 | Apelin signaling pathway | 31 | 104 | 3.08e-03 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | 31 | 105 | 3.49e-03 |
| KEGG | KEGG:04512 | ECM-receptor interaction | 22 | 66 | 4.36e-03 |
| KEGG | KEGG:04927 | Cortisol synthesis and secretion | 17 | 46 | 5.32e-03 |
| KEGG | KEGG:04974 | Protein digestion and absorption | 19 | 56 | 8.00e-03 |
| KEGG | KEGG:04973 | Carbohydrate digestion and absorption | 12 | 29 | 1.11e-02 |
| KEGG | KEGG:04911 | Insulin secretion | 20 | 62 | 1.11e-02 |
| KEGG | KEGG:04022 | cGMP-PKG signaling pathway | 34 | 129 | 1.28e-02 |
| KEGG | KEGG:04148 | Efferocytosis | 32 | 120 | 1.28e-02 |
| KEGG | KEGG:04931 | Insulin resistance | 26 | 91 | 1.28e-02 |
| KEGG | KEGG:04360 | Axon guidance | 39 | 155 | 1.28e-02 |
| KEGG | KEGG:05215 | Prostate cancer | 24 | 82 | 1.28e-02 |
| KEGG | KEGG:04020 | Calcium signaling pathway | 40 | 161 | 1.33e-02 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 40 | 162 | 1.41e-02 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | 40 | 162 | 1.41e-02 |
| KEGG | KEGG:05203 | Viral carcinogenesis | 36 | 142 | 1.42e-02 |
| KEGG | KEGG:04972 | Pancreatic secretion | 18 | 57 | 1.74e-02 |
| KEGG | KEGG:05146 | Amoebiasis | 19 | 62 | 1.82e-02 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | 39 | 160 | 1.82e-02 |
| KEGG | KEGG:00000 | KEGG root term | 893 | 5451 | 1.83e-02 |
| KEGG | KEGG:04750 | Inflammatory mediator regulation of TRP channels | 21 | 72 | 2.00e-02 |
| KEGG | KEGG:05222 | Small cell lung cancer | 23 | 82 | 2.15e-02 |
| KEGG | KEGG:04713 | Circadian entrainment | 20 | 68 | 2.15e-02 |
| KEGG | KEGG:00330 | Arginine and proline metabolism | 12 | 33 | 2.22e-02 |
| KEGG | KEGG:04740 | Olfactory transduction | 10 | 25 | 2.22e-02 |
| KEGG | KEGG:04520 | Adherens junction | 23 | 83 | 2.29e-02 |
| KEGG | KEGG:04611 | Platelet activation | 24 | 88 | 2.30e-02 |
| KEGG | KEGG:05131 | Shigellosis | 46 | 204 | 3.02e-02 |
| KEGG | KEGG:04330 | Notch signaling pathway | 16 | 52 | 3.02e-02 |
| KEGG | KEGG:04930 | Type II diabetes mellitus | 12 | 35 | 3.33e-02 |
| KEGG | KEGG:04024 | cAMP signaling pathway | 35 | 147 | 3.33e-02 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | 23 | 87 | 3.76e-02 |
| KEGG | KEGG:04961 | Endocrine and other factor-regulated calcium reabsorption | 13 | 40 | 3.76e-02 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | 27 | 109 | 4.52e-02 |
| KEGG | KEGG:04976 | Bile secretion | 13 | 41 | 4.52e-02 |
| KEGG | KEGG:04934 | Cushing syndrome | 29 | 119 | 4.52e-02 |
| KEGG | KEGG:00532 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 8 | 20 | 4.54e-02 |
NR 20,000 bp NG
# NR_resgenes_20k <- gost(query = NR_peak_list_20k$ENTREZID,
# organism = "hsapiens",
# significant = FALSE,
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = background_df$ENTREZID,
# sources=c("GO:BP","KEGG"))
# saveRDS(NR_resgenes_20k,"data/GO_KEGG_analysis/NR_resgenes_20k.RDS")
# NRnom <- gostplot(NR_resgenes_20k, capped = FALSE, interactive = TRUE)
# NRnom
NRnomtable_20k <- NR_resgenes_20k$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
NRnomtable_20k %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in NR nESRgenes_20k" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0032501 | multicellular organismal process | 4317 | 4504 | 9.74e-06 |
| GO:BP | GO:0007275 | multicellular organism development | 3050 | 3170 | 1.83e-05 |
| GO:BP | GO:0048856 | anatomical structure development | 3708 | 3867 | 6.42e-05 |
| GO:BP | GO:0048731 | system development | 2618 | 2719 | 7.09e-05 |
| GO:BP | GO:0008150 | biological_process | 10636 | 11244 | 8.31e-05 |
| GO:BP | GO:0032502 | developmental process | 4001 | 4179 | 8.31e-05 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 3406 | 3550 | 8.31e-05 |
| GO:BP | GO:0051716 | cellular response to stimulus | 4437 | 4640 | 8.31e-05 |
| GO:BP | GO:0050794 | regulation of cellular process | 6806 | 7153 | 1.22e-04 |
| GO:BP | GO:0050896 | response to stimulus | 5133 | 5379 | 1.72e-04 |
| GO:BP | GO:0065007 | biological regulation | 7350 | 7734 | 2.63e-04 |
| GO:BP | GO:0050789 | regulation of biological process | 7144 | 7516 | 3.70e-04 |
| GO:BP | GO:0007154 | cell communication | 3811 | 3983 | 3.83e-04 |
| GO:BP | GO:0023052 | signaling | 3749 | 3918 | 4.40e-04 |
| GO:BP | GO:0007010 | cytoskeleton organization | 1113 | 1146 | 8.70e-04 |
| GO:BP | GO:0007399 | nervous system development | 1713 | 1775 | 9.59e-04 |
| GO:BP | GO:0009987 | cellular process | 10111 | 10686 | 9.59e-04 |
| GO:BP | GO:0007165 | signal transduction | 3456 | 3611 | 9.61e-04 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 1778 | 1844 | 1.25e-03 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 1006 | 1035 | 1.25e-03 |
| GO:BP | GO:0022008 | neurogenesis | 1212 | 1251 | 1.74e-03 |
| GO:BP | GO:0048519 | negative regulation of biological process | 3599 | 3764 | 1.74e-03 |
| GO:BP | GO:0048869 | cellular developmental process | 2688 | 2804 | 2.76e-03 |
| GO:BP | GO:0007015 | actin filament organization | 353 | 357 | 2.76e-03 |
| GO:BP | GO:0016043 | cellular component organization | 4579 | 4802 | 2.76e-03 |
| GO:BP | GO:0030154 | cell differentiation | 2687 | 2803 | 2.76e-03 |
| GO:BP | GO:0030029 | actin filament-based process | 626 | 640 | 2.76e-03 |
| GO:BP | GO:0048518 | positive regulation of biological process | 4105 | 4301 | 2.96e-03 |
| GO:BP | GO:0023051 | regulation of signaling | 2340 | 2438 | 3.51e-03 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 3776 | 3954 | 3.89e-03 |
| GO:BP | GO:0048699 | generation of neurons | 1043 | 1076 | 4.39e-03 |
| GO:BP | GO:0050793 | regulation of developmental process | 1635 | 1697 | 4.59e-03 |
| GO:BP | GO:0035556 | intracellular signal transduction | 1876 | 1951 | 5.84e-03 |
| GO:BP | GO:0009888 | tissue development | 1302 | 1348 | 5.84e-03 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 1158 | 1197 | 5.84e-03 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | 297 | 300 | 6.20e-03 |
| GO:BP | GO:0010646 | regulation of cell communication | 2344 | 2444 | 6.20e-03 |
| GO:BP | GO:0030182 | neuron differentiation | 983 | 1014 | 6.20e-03 |
| GO:BP | GO:0097435 | supramolecular fiber organization | 618 | 633 | 6.72e-03 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | 259 | 261 | 7.37e-03 |
| GO:BP | GO:0006996 | organelle organization | 2695 | 2815 | 8.01e-03 |
| GO:BP | GO:0009966 | regulation of signal transduction | 2079 | 2166 | 8.77e-03 |
| GO:BP | GO:0048468 | cell development | 1813 | 1886 | 8.77e-03 |
| GO:BP | GO:0048513 | animal organ development | 1925 | 2004 | 9.14e-03 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 1790 | 1862 | 9.19e-03 |
| GO:BP | GO:0007267 | cell-cell signaling | 1047 | 1082 | 9.96e-03 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | 553 | 566 | 1.03e-02 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | 425 | 433 | 1.03e-02 |
| GO:BP | GO:0000902 | cell morphogenesis | 694 | 713 | 1.03e-02 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 2601 | 2717 | 1.03e-02 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 4749 | 4988 | 1.03e-02 |
| GO:BP | GO:0043087 | regulation of GTPase activity | 166 | 166 | 1.22e-02 |
| GO:BP | GO:0016477 | cell migration | 978 | 1011 | 1.97e-02 |
| GO:BP | GO:0198738 | cell-cell signaling by wnt | 353 | 359 | 2.16e-02 |
| GO:BP | GO:0016055 | Wnt signaling pathway | 352 | 358 | 2.22e-02 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | 404 | 412 | 2.31e-02 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | 1110 | 1150 | 2.63e-02 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 2312 | 2415 | 2.73e-02 |
| GO:BP | GO:0030030 | cell projection organization | 1140 | 1182 | 3.40e-02 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 1845 | 1924 | 4.34e-02 |
NRnomtable_20k %>%
filter(source=="KEGG", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in NR nESRgenes_20k") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| NA | NA | NA | NA | NA | NA |
| :—— | :——- | :——— | —————–: | ———: | :——- |
NR peaks overlapping enhancers
# NR_resgenes_20k_enh <- gost(query = unique(NR_enh_peaks_20k$NCBI_gene),
# organism = "hsapiens",
# significant = FALSE,
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = background_df$ENTREZID,
# sources=c("GO:BP","KEGG"))
# saveRDS(NR_resgenes_20k_enh,"data/GO_KEGG_analysis/NR_resgenes_20k_enh.RDS")
# NRnom <- gostplot(NR_resgenes_20k_enh, capped = FALSE, interactive = TRUE)
# NRnom
NRnomtable_20k_enh <- NR_resgenes_20k_enh$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
NRnomtable_20k_enh %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in NR neargenes_20k" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0065007 | biological regulation | 4230 | 7734 | 9.66e-28 |
| GO:BP | GO:0050789 | regulation of biological process | 4120 | 7516 | 1.29e-27 |
| GO:BP | GO:0050794 | regulation of cellular process | 3931 | 7153 | 3.23e-26 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 2068 | 3550 | 5.64e-24 |
| GO:BP | GO:0007165 | signal transduction | 2097 | 3611 | 1.83e-23 |
| GO:BP | GO:0048519 | negative regulation of biological process | 2176 | 3764 | 3.12e-23 |
| GO:BP | GO:0051716 | cellular response to stimulus | 2632 | 4640 | 5.29e-23 |
| GO:BP | GO:0050896 | response to stimulus | 3012 | 5379 | 6.75e-23 |
| GO:BP | GO:0008150 | biological_process | 5864 | 11244 | 8.77e-23 |
| GO:BP | GO:0023052 | signaling | 2243 | 3918 | 5.28e-21 |
| GO:BP | GO:0048518 | positive regulation of biological process | 2442 | 4301 | 7.27e-21 |
| GO:BP | GO:0007154 | cell communication | 2275 | 3983 | 9.78e-21 |
| GO:BP | GO:0019222 | regulation of metabolic process | 2585 | 4603 | 9.97e-19 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | 1539 | 2622 | 4.31e-18 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 2243 | 3954 | 4.41e-18 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 1588 | 2717 | 8.05e-18 |
| GO:BP | GO:0071310 | cellular response to organic substance | 813 | 1297 | 1.07e-17 |
| GO:BP | GO:0009987 | cellular process | 5587 | 10686 | 1.45e-17 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | 1063 | 1751 | 2.03e-17 |
| GO:BP | GO:0051172 | negative regulation of nitrogen compound metabolic process | 997 | 1633 | 3.36e-17 |
| GO:BP | GO:0010033 | response to organic substance | 1053 | 1736 | 4.29e-17 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | 2378 | 4231 | 8.17e-17 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | 840 | 1354 | 1.08e-16 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 752 | 1197 | 1.19e-16 |
| GO:BP | GO:0009966 | regulation of signal transduction | 1284 | 2166 | 1.42e-16 |
| GO:BP | GO:0080090 | regulation of primary metabolic process | 2263 | 4015 | 1.63e-16 |
| GO:BP | GO:0042221 | response to chemical | 1358 | 2304 | 1.63e-16 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | 1247 | 2100 | 2.22e-16 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | 1549 | 2663 | 2.59e-16 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 1416 | 2415 | 2.82e-16 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | 1165 | 1951 | 3.39e-16 |
| GO:BP | GO:0051173 | positive regulation of nitrogen compound metabolic process | 1292 | 2186 | 3.63e-16 |
| GO:BP | GO:0030029 | actin filament-based process | 431 | 640 | 3.91e-16 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 658 | 1035 | 4.03e-16 |
| GO:BP | GO:0031324 | negative regulation of cellular metabolic process | 1155 | 1934 | 4.21e-16 |
| GO:BP | GO:0051171 | regulation of nitrogen compound metabolic process | 2208 | 3918 | 5.56e-16 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | 617 | 965 | 8.15e-16 |
| GO:BP | GO:0031323 | regulation of cellular metabolic process | 2370 | 4233 | 1.00e-15 |
| GO:BP | GO:0035556 | intracellular signal transduction | 1162 | 1951 | 1.00e-15 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | 621 | 973 | 1.04e-15 |
| GO:BP | GO:0032502 | developmental process | 2340 | 4179 | 1.77e-15 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | 673 | 1067 | 1.89e-15 |
| GO:BP | GO:0010468 | regulation of gene expression | 1921 | 3379 | 2.41e-15 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | 1412 | 2422 | 4.20e-15 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | 1405 | 2410 | 5.14e-15 |
| GO:BP | GO:0031325 | positive regulation of cellular metabolic process | 1362 | 2333 | 9.91e-15 |
| GO:BP | GO:0048856 | anatomical structure development | 2172 | 3867 | 9.91e-15 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 917 | 1514 | 1.50e-14 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | 957 | 1588 | 1.92e-14 |
| GO:BP | GO:0010646 | regulation of cell communication | 1419 | 2444 | 2.31e-14 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | 761 | 1234 | 2.75e-14 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | 1969 | 3486 | 3.09e-14 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | 759 | 1231 | 3.09e-14 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | 381 | 566 | 3.09e-14 |
| GO:BP | GO:0006351 | DNA-templated transcription | 1452 | 2510 | 4.74e-14 |
| GO:BP | GO:1901698 | response to nitrogen compound | 479 | 736 | 4.74e-14 |
| GO:BP | GO:0032774 | RNA biosynthetic process | 1464 | 2533 | 5.13e-14 |
| GO:BP | GO:0031327 | negative regulation of cellular biosynthetic process | 974 | 1624 | 5.40e-14 |
| GO:BP | GO:0023051 | regulation of signaling | 1413 | 2438 | 5.59e-14 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | 1070 | 1801 | 6.07e-14 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 716 | 1157 | 6.93e-14 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | 979 | 1635 | 7.85e-14 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 1092 | 1844 | 1.00e-13 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | 2021 | 3595 | 1.35e-13 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | 1653 | 2895 | 1.37e-13 |
| GO:BP | GO:0031326 | regulation of cellular biosynthetic process | 2007 | 3569 | 1.50e-13 |
| GO:BP | GO:0010243 | response to organonitrogen compound | 447 | 685 | 2.19e-13 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | 1059 | 1791 | 5.37e-13 |
| GO:BP | GO:0050793 | regulation of developmental process | 1008 | 1697 | 5.37e-13 |
| GO:BP | GO:0048869 | cellular developmental process | 1600 | 2804 | 6.75e-13 |
| GO:BP | GO:0030154 | cell differentiation | 1599 | 2803 | 7.81e-13 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | 1055 | 1787 | 1.08e-12 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | 1091 | 1856 | 1.78e-12 |
| GO:BP | GO:0045595 | regulation of cell differentiation | 662 | 1073 | 2.23e-12 |
| GO:BP | GO:0031328 | positive regulation of cellular biosynthetic process | 1082 | 1841 | 2.47e-12 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | 323 | 479 | 3.53e-12 |
| GO:BP | GO:0036211 | protein modification process | 1322 | 2291 | 4.14e-12 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | 505 | 796 | 4.89e-12 |
| GO:BP | GO:0141124 | intracellular signaling cassette | 793 | 1314 | 5.91e-12 |
| GO:BP | GO:0071417 | cellular response to organonitrogen compound | 300 | 442 | 8.21e-12 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | 670 | 1093 | 9.42e-12 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | 777 | 1289 | 1.57e-11 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | 1097 | 1879 | 1.83e-11 |
| GO:BP | GO:0018130 | heterocycle biosynthetic process | 1654 | 2927 | 2.01e-11 |
| GO:BP | GO:1901362 | organic cyclic compound biosynthetic process | 1705 | 3026 | 2.77e-11 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | 1621 | 2867 | 3.05e-11 |
| GO:BP | GO:0019438 | aromatic compound biosynthetic process | 1652 | 2928 | 4.27e-11 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | 303 | 452 | 6.27e-11 |
| GO:BP | GO:0009725 | response to hormone | 394 | 610 | 8.60e-11 |
| GO:BP | GO:0097435 | supramolecular fiber organization | 407 | 633 | 9.37e-11 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | 720 | 1193 | 9.39e-11 |
| GO:BP | GO:0032870 | cellular response to hormone stimulus | 291 | 433 | 1.11e-10 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | 597 | 972 | 1.38e-10 |
| GO:BP | GO:0051093 | negative regulation of developmental process | 400 | 622 | 1.38e-10 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | 542 | 874 | 1.63e-10 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 446 | 704 | 1.96e-10 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | 453 | 717 | 2.37e-10 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 1113 | 1924 | 3.01e-10 |
| GO:BP | GO:0007275 | multicellular organism development | 1772 | 3170 | 3.07e-10 |
| GO:BP | GO:0032501 | multicellular organismal process | 2464 | 4504 | 3.29e-10 |
| GO:BP | GO:0007015 | actin filament organization | 244 | 357 | 5.05e-10 |
| GO:BP | GO:0023057 | negative regulation of signaling | 629 | 1036 | 6.35e-10 |
| GO:BP | GO:0043434 | response to peptide hormone | 218 | 314 | 6.60e-10 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | 884 | 1504 | 8.18e-10 |
| GO:BP | GO:0010648 | negative regulation of cell communication | 627 | 1034 | 9.27e-10 |
| GO:BP | GO:1901652 | response to peptide | 249 | 368 | 1.52e-09 |
| GO:BP | GO:0016477 | cell migration | 612 | 1011 | 2.57e-09 |
| GO:BP | GO:0072359 | circulatory system development | 529 | 864 | 5.47e-09 |
| GO:BP | GO:0007010 | cytoskeleton organization | 684 | 1146 | 6.28e-09 |
| GO:BP | GO:0001944 | vasculature development | 353 | 552 | 7.66e-09 |
| GO:BP | GO:0008152 | metabolic process | 4177 | 7921 | 1.78e-08 |
| GO:BP | GO:0044271 | cellular nitrogen compound biosynthetic process | 1926 | 3495 | 1.88e-08 |
| GO:BP | GO:0009605 | response to external stimulus | 903 | 1559 | 3.62e-08 |
| GO:BP | GO:0032868 | response to insulin | 146 | 203 | 3.94e-08 |
| GO:BP | GO:0030155 | regulation of cell adhesion | 325 | 508 | 4.00e-08 |
| GO:BP | GO:0071375 | cellular response to peptide hormone stimulus | 163 | 231 | 4.09e-08 |
| GO:BP | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 295 | 456 | 4.54e-08 |
| GO:BP | GO:0006793 | phosphorus metabolic process | 1086 | 1904 | 5.64e-08 |
| GO:BP | GO:0001568 | blood vessel development | 334 | 525 | 5.72e-08 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | 371 | 591 | 6.96e-08 |
| GO:BP | GO:0009888 | tissue development | 787 | 1348 | 7.67e-08 |
| GO:BP | GO:0198738 | cell-cell signaling by wnt | 238 | 359 | 7.75e-08 |
| GO:BP | GO:0048513 | animal organ development | 1138 | 2004 | 7.75e-08 |
| GO:BP | GO:0048731 | system development | 1515 | 2719 | 8.04e-08 |
| GO:BP | GO:0002376 | immune system process | 820 | 1410 | 8.73e-08 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | 1073 | 1883 | 9.32e-08 |
| GO:BP | GO:0016055 | Wnt signaling pathway | 237 | 358 | 9.96e-08 |
| GO:BP | GO:1901653 | cellular response to peptide | 187 | 273 | 9.97e-08 |
| GO:BP | GO:0044238 | primary metabolic process | 3816 | 7216 | 1.09e-07 |
| GO:BP | GO:0071407 | cellular response to organic cyclic compound | 249 | 379 | 1.11e-07 |
| GO:BP | GO:0030334 | regulation of cell migration | 413 | 668 | 1.20e-07 |
| GO:BP | GO:0065009 | regulation of molecular function | 759 | 1299 | 1.22e-07 |
| GO:BP | GO:0019538 | protein metabolic process | 1982 | 3619 | 1.27e-07 |
| GO:BP | GO:0065008 | regulation of biological quality | 1077 | 1893 | 1.32e-07 |
| GO:BP | GO:0016310 | phosphorylation | 675 | 1145 | 1.45e-07 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | 202 | 300 | 1.95e-07 |
| GO:BP | GO:0043412 | macromolecule modification | 1390 | 2489 | 2.29e-07 |
| GO:BP | GO:0051246 | regulation of protein metabolic process | 916 | 1595 | 2.43e-07 |
| GO:BP | GO:0051179 | localization | 2037 | 3731 | 2.47e-07 |
| GO:BP | GO:0061061 | muscle structure development | 337 | 536 | 2.89e-07 |
| GO:BP | GO:0071704 | organic substance metabolic process | 3992 | 7578 | 3.25e-07 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | 277 | 431 | 3.43e-07 |
| GO:BP | GO:0006810 | transport | 1647 | 2984 | 3.85e-07 |
| GO:BP | GO:0007155 | cell adhesion | 561 | 941 | 3.97e-07 |
| GO:BP | GO:0008283 | cell population proliferation | 759 | 1306 | 4.22e-07 |
| GO:BP | GO:0043170 | macromolecule metabolic process | 3474 | 6550 | 4.26e-07 |
| GO:BP | GO:0030097 | hemopoiesis | 385 | 624 | 5.69e-07 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | 503 | 837 | 5.69e-07 |
| GO:BP | GO:0051336 | regulation of hydrolase activity | 276 | 431 | 5.89e-07 |
| GO:BP | GO:0035295 | tube development | 475 | 787 | 6.84e-07 |
| GO:BP | GO:0040011 | locomotion | 484 | 805 | 1.01e-06 |
| GO:BP | GO:2000145 | regulation of cell motility | 426 | 700 | 1.01e-06 |
| GO:BP | GO:0051094 | positive regulation of developmental process | 543 | 913 | 1.10e-06 |
| GO:BP | GO:0046907 | intracellular transport | 677 | 1160 | 1.21e-06 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | 632 | 1077 | 1.22e-06 |
| GO:BP | GO:0060070 | canonical Wnt signaling pathway | 165 | 242 | 1.31e-06 |
| GO:BP | GO:0006468 | protein phosphorylation | 567 | 958 | 1.34e-06 |
| GO:BP | GO:0014070 | response to organic cyclic compound | 373 | 606 | 1.36e-06 |
| GO:BP | GO:0040012 | regulation of locomotion | 436 | 720 | 1.55e-06 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | 639 | 1093 | 2.16e-06 |
| GO:BP | GO:0048468 | cell development | 1063 | 1886 | 2.24e-06 |
| GO:BP | GO:0048870 | cell motility | 653 | 1120 | 2.65e-06 |
| GO:BP | GO:0042592 | homeostatic process | 662 | 1137 | 2.81e-06 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | 373 | 609 | 2.89e-06 |
| GO:BP | GO:0016070 | RNA metabolic process | 1829 | 3352 | 3.05e-06 |
| GO:BP | GO:0006807 | nitrogen compound metabolic process | 3646 | 6912 | 3.19e-06 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | 609 | 1040 | 3.29e-06 |
| GO:BP | GO:0016567 | protein ubiquitination | 377 | 617 | 3.47e-06 |
| GO:BP | GO:0032869 | cellular response to insulin stimulus | 115 | 161 | 3.66e-06 |
| GO:BP | GO:0006915 | apoptotic process | 790 | 1377 | 3.84e-06 |
| GO:BP | GO:0070647 | protein modification by small protein conjugation or removal | 459 | 766 | 3.92e-06 |
| GO:BP | GO:0048514 | blood vessel morphogenesis | 283 | 450 | 4.25e-06 |
| GO:BP | GO:0006950 | response to stress | 1404 | 2540 | 4.76e-06 |
| GO:BP | GO:0043687 | post-translational protein modification | 483 | 811 | 5.09e-06 |
| GO:BP | GO:0044092 | negative regulation of molecular function | 313 | 504 | 5.16e-06 |
| GO:BP | GO:0012501 | programmed cell death | 811 | 1419 | 5.87e-06 |
| GO:BP | GO:0044237 | cellular metabolic process | 3716 | 7058 | 5.91e-06 |
| GO:BP | GO:0030099 | myeloid cell differentiation | 192 | 292 | 5.94e-06 |
| GO:BP | GO:0051248 | negative regulation of protein metabolic process | 369 | 605 | 6.01e-06 |
| GO:BP | GO:0031399 | regulation of protein modification process | 536 | 911 | 8.98e-06 |
| GO:BP | GO:0002684 | positive regulation of immune system process | 354 | 580 | 9.88e-06 |
| GO:BP | GO:0060828 | regulation of canonical Wnt signaling pathway | 139 | 203 | 1.01e-05 |
| GO:BP | GO:0016043 | cellular component organization | 2569 | 4802 | 1.02e-05 |
| GO:BP | GO:0033993 | response to lipid | 350 | 573 | 1.02e-05 |
| GO:BP | GO:0035239 | tube morphogenesis | 386 | 638 | 1.03e-05 |
| GO:BP | GO:0008219 | cell death | 811 | 1423 | 1.06e-05 |
| GO:BP | GO:0032956 | regulation of actin cytoskeleton organization | 173 | 261 | 1.07e-05 |
| GO:BP | GO:0030111 | regulation of Wnt signaling pathway | 173 | 261 | 1.07e-05 |
| GO:BP | GO:1901564 | organonitrogen compound metabolic process | 2339 | 4354 | 1.09e-05 |
| GO:BP | GO:0009894 | regulation of catabolic process | 490 | 830 | 1.73e-05 |
| GO:BP | GO:0060284 | regulation of cell development | 347 | 570 | 1.78e-05 |
| GO:BP | GO:0032446 | protein modification by small protein conjugation | 416 | 695 | 1.78e-05 |
| GO:BP | GO:0042692 | muscle cell differentiation | 208 | 323 | 1.78e-05 |
| GO:BP | GO:0030335 | positive regulation of cell migration | 249 | 395 | 1.78e-05 |
| GO:BP | GO:0051234 | establishment of localization | 1762 | 3240 | 1.81e-05 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | 476 | 805 | 1.92e-05 |
| GO:BP | GO:0070848 | response to growth factor | 334 | 547 | 1.94e-05 |
| GO:BP | GO:0044249 | cellular biosynthetic process | 2897 | 5453 | 2.03e-05 |
| GO:BP | GO:0007507 | heart development | 307 | 499 | 2.17e-05 |
| GO:BP | GO:1901576 | organic substance biosynthetic process | 2925 | 5509 | 2.20e-05 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | 475 | 804 | 2.23e-05 |
| GO:BP | GO:0051493 | regulation of cytoskeleton organization | 258 | 412 | 2.35e-05 |
| GO:BP | GO:0023056 | positive regulation of signaling | 700 | 1221 | 2.41e-05 |
| GO:BP | GO:0030522 | intracellular receptor signaling pathway | 167 | 253 | 2.44e-05 |
| GO:BP | GO:0010629 | negative regulation of gene expression | 467 | 790 | 2.51e-05 |
| GO:BP | GO:0044419 | biological process involved in interspecies interaction between organisms | 544 | 932 | 2.66e-05 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 1040 | 1862 | 2.78e-05 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | 554 | 951 | 2.91e-05 |
| GO:BP | GO:1902903 | regulation of supramolecular fiber organization | 196 | 304 | 3.18e-05 |
| GO:BP | GO:0031400 | negative regulation of protein modification process | 208 | 325 | 3.21e-05 |
| GO:BP | GO:0043254 | regulation of protein-containing complex assembly | 209 | 327 | 3.46e-05 |
| GO:BP | GO:0010647 | positive regulation of cell communication | 697 | 1218 | 3.54e-05 |
| GO:BP | GO:0009058 | biosynthetic process | 2941 | 5547 | 3.81e-05 |
| GO:BP | GO:0009059 | macromolecule biosynthetic process | 2574 | 4827 | 3.83e-05 |
| GO:BP | GO:0042981 | regulation of apoptotic process | 596 | 1031 | 4.20e-05 |
| GO:BP | GO:0050790 | regulation of catalytic activity | 521 | 893 | 4.89e-05 |
| GO:BP | GO:0043067 | regulation of programmed cell death | 611 | 1060 | 5.07e-05 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | 321 | 528 | 5.32e-05 |
| GO:BP | GO:0002682 | regulation of immune system process | 507 | 868 | 5.65e-05 |
| GO:BP | GO:0016192 | vesicle-mediated transport | 660 | 1152 | 5.65e-05 |
| GO:BP | GO:0034097 | response to cytokine | 354 | 588 | 5.67e-05 |
| GO:BP | GO:0080134 | regulation of response to stress | 539 | 928 | 6.55e-05 |
| GO:BP | GO:0009991 | response to extracellular stimulus | 236 | 377 | 6.93e-05 |
| GO:BP | GO:0050776 | regulation of immune response | 292 | 477 | 6.98e-05 |
| GO:BP | GO:0001525 | angiogenesis | 238 | 381 | 7.84e-05 |
| GO:BP | GO:0051146 | striated muscle cell differentiation | 154 | 234 | 8.08e-05 |
| GO:BP | GO:2000147 | positive regulation of cell motility | 253 | 408 | 8.51e-05 |
| GO:BP | GO:0048762 | mesenchymal cell differentiation | 134 | 200 | 8.90e-05 |
| GO:BP | GO:0071345 | cellular response to cytokine stimulus | 318 | 525 | 9.14e-05 |
| GO:BP | GO:0000902 | cell morphogenesis | 421 | 713 | 1.01e-04 |
| GO:BP | GO:0050778 | positive regulation of immune response | 235 | 377 | 1.12e-04 |
| GO:BP | GO:0071396 | cellular response to lipid | 241 | 388 | 1.22e-04 |
| GO:BP | GO:0007264 | small GTPase-mediated signal transduction | 242 | 390 | 1.30e-04 |
| GO:BP | GO:0001667 | ameboidal-type cell migration | 216 | 344 | 1.36e-04 |
| GO:BP | GO:0070936 | protein K48-linked ubiquitination | 57 | 74 | 1.36e-04 |
| GO:BP | GO:0045936 | negative regulation of phosphate metabolic process | 184 | 288 | 1.50e-04 |
| GO:BP | GO:0051247 | positive regulation of protein metabolic process | 527 | 911 | 1.57e-04 |
| GO:BP | GO:0061448 | connective tissue development | 136 | 205 | 1.63e-04 |
| GO:BP | GO:0010467 | gene expression | 2372 | 4449 | 1.64e-04 |
| GO:BP | GO:0040017 | positive regulation of locomotion | 256 | 416 | 1.65e-04 |
| GO:BP | GO:0006897 | endocytosis | 298 | 492 | 1.85e-04 |
| GO:BP | GO:0051345 | positive regulation of hydrolase activity | 171 | 266 | 1.87e-04 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | 443 | 757 | 1.94e-04 |
| GO:BP | GO:0033554 | cellular response to stress | 805 | 1433 | 1.96e-04 |
| GO:BP | GO:0044093 | positive regulation of molecular function | 457 | 783 | 1.99e-04 |
| GO:BP | GO:0010563 | negative regulation of phosphorus metabolic process | 184 | 289 | 2.00e-04 |
| GO:BP | GO:0032879 | regulation of localization | 808 | 1439 | 2.03e-04 |
| GO:BP | GO:0006955 | immune response | 502 | 867 | 2.27e-04 |
| GO:BP | GO:0006470 | protein dephosphorylation | 119 | 177 | 2.36e-04 |
| GO:BP | GO:1902533 | positive regulation of intracellular signal transduction | 419 | 714 | 2.36e-04 |
| GO:BP | GO:0016311 | dephosphorylation | 151 | 232 | 2.38e-04 |
| GO:BP | GO:0048872 | homeostasis of number of cells | 145 | 222 | 2.74e-04 |
| GO:BP | GO:0001837 | epithelial to mesenchymal transition | 95 | 137 | 2.87e-04 |
| GO:BP | GO:0032922 | circadian regulation of gene expression | 46 | 58 | 2.88e-04 |
| GO:BP | GO:0031667 | response to nutrient levels | 220 | 354 | 2.89e-04 |
| GO:BP | GO:0051241 | negative regulation of multicellular organismal process | 414 | 706 | 2.91e-04 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | 284 | 469 | 3.01e-04 |
| GO:BP | GO:0060485 | mesenchyme development | 158 | 245 | 3.12e-04 |
| GO:BP | GO:0098657 | import into cell | 368 | 622 | 3.13e-04 |
| GO:BP | GO:0071496 | cellular response to external stimulus | 171 | 268 | 3.40e-04 |
| GO:BP | GO:0051641 | cellular localization | 1426 | 2623 | 3.50e-04 |
| GO:BP | GO:0010717 | regulation of epithelial to mesenchymal transition | 63 | 85 | 3.55e-04 |
| GO:BP | GO:0014902 | myotube differentiation | 63 | 85 | 3.55e-04 |
| GO:BP | GO:0034101 | erythrocyte homeostasis | 79 | 111 | 3.58e-04 |
| GO:BP | GO:0007162 | negative regulation of cell adhesion | 123 | 185 | 3.63e-04 |
| GO:BP | GO:0043065 | positive regulation of apoptotic process | 234 | 380 | 3.66e-04 |
| GO:BP | GO:0003012 | muscle system process | 203 | 325 | 3.91e-04 |
| GO:BP | GO:0009896 | positive regulation of catabolic process | 265 | 436 | 3.95e-04 |
| GO:BP | GO:0048871 | multicellular organismal-level homeostasis | 320 | 536 | 4.27e-04 |
| GO:BP | GO:0007520 | myoblast fusion | 26 | 29 | 4.50e-04 |
| GO:BP | GO:0032271 | regulation of protein polymerization | 108 | 160 | 4.50e-04 |
| GO:BP | GO:0031032 | actomyosin structure organization | 122 | 184 | 4.70e-04 |
| GO:BP | GO:0010631 | epithelial cell migration | 156 | 243 | 4.88e-04 |
| GO:BP | GO:0090132 | epithelium migration | 156 | 243 | 4.88e-04 |
| GO:BP | GO:0045444 | fat cell differentiation | 119 | 179 | 4.92e-04 |
| GO:BP | GO:0003170 | heart valve development | 50 | 65 | 5.13e-04 |
| GO:BP | GO:0002253 | activation of immune response | 182 | 289 | 5.35e-04 |
| GO:BP | GO:0022604 | regulation of cell morphogenesis | 127 | 193 | 5.37e-04 |
| GO:BP | GO:0110053 | regulation of actin filament organization | 138 | 212 | 5.37e-04 |
| GO:BP | GO:0051056 | regulation of small GTPase mediated signal transduction | 150 | 233 | 5.61e-04 |
| GO:BP | GO:0030218 | erythrocyte differentiation | 74 | 104 | 6.58e-04 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 2638 | 4988 | 6.67e-04 |
| GO:BP | GO:0010628 | positive regulation of gene expression | 433 | 746 | 6.67e-04 |
| GO:BP | GO:0010921 | regulation of phosphatase activity | 36 | 44 | 7.55e-04 |
| GO:BP | GO:0002262 | myeloid cell homeostasis | 93 | 136 | 7.81e-04 |
| GO:BP | GO:0045785 | positive regulation of cell adhesion | 188 | 301 | 7.81e-04 |
| GO:BP | GO:0008360 | regulation of cell shape | 75 | 106 | 7.81e-04 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | 54 | 72 | 8.11e-04 |
| GO:BP | GO:0090257 | regulation of muscle system process | 117 | 177 | 8.26e-04 |
| GO:BP | GO:0030323 | respiratory tube development | 100 | 148 | 8.30e-04 |
| GO:BP | GO:0002521 | leukocyte differentiation | 227 | 371 | 8.49e-04 |
| GO:BP | GO:0009607 | response to biotic stimulus | 472 | 820 | 8.65e-04 |
| GO:BP | GO:0008286 | insulin receptor signaling pathway | 70 | 98 | 8.65e-04 |
| GO:BP | GO:0042325 | regulation of phosphorylation | 398 | 683 | 8.70e-04 |
| GO:BP | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 178 | 284 | 9.37e-04 |
| GO:BP | GO:0090130 | tissue migration | 157 | 247 | 9.47e-04 |
| GO:BP | GO:0031668 | cellular response to extracellular stimulus | 141 | 219 | 9.47e-04 |
| GO:BP | GO:0010810 | regulation of cell-substrate adhesion | 108 | 162 | 9.48e-04 |
| GO:BP | GO:0003179 | heart valve morphogenesis | 43 | 55 | 9.59e-04 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | 328 | 555 | 9.74e-04 |
| GO:BP | GO:0046649 | lymphocyte activation | 267 | 444 | 1.00e-03 |
| GO:BP | GO:0043068 | positive regulation of programmed cell death | 236 | 388 | 1.01e-03 |
| GO:BP | GO:0014897 | striated muscle hypertrophy | 55 | 74 | 1.01e-03 |
| GO:BP | GO:0035966 | response to topologically incorrect protein | 89 | 130 | 1.03e-03 |
| GO:BP | GO:0045646 | regulation of erythrocyte differentiation | 29 | 34 | 1.03e-03 |
| GO:BP | GO:0031589 | cell-substrate adhesion | 163 | 258 | 1.05e-03 |
| GO:BP | GO:0010586 | miRNA metabolic process | 63 | 87 | 1.06e-03 |
| GO:BP | GO:0051707 | response to other organism | 457 | 794 | 1.13e-03 |
| GO:BP | GO:0043207 | response to external biotic stimulus | 457 | 794 | 1.13e-03 |
| GO:BP | GO:0048878 | chemical homeostasis | 390 | 670 | 1.14e-03 |
| GO:BP | GO:0043087 | regulation of GTPase activity | 110 | 166 | 1.15e-03 |
| GO:BP | GO:0051494 | negative regulation of cytoskeleton organization | 87 | 127 | 1.18e-03 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | 46 | 60 | 1.18e-03 |
| GO:BP | GO:0008064 | regulation of actin polymerization or depolymerization | 81 | 117 | 1.21e-03 |
| GO:BP | GO:0030324 | lung development | 97 | 144 | 1.23e-03 |
| GO:BP | GO:0006996 | organelle organization | 1518 | 2815 | 1.23e-03 |
| GO:BP | GO:0036293 | response to decreased oxygen levels | 154 | 243 | 1.33e-03 |
| GO:BP | GO:0055001 | muscle cell development | 108 | 163 | 1.33e-03 |
| GO:BP | GO:0001775 | cell activation | 366 | 627 | 1.41e-03 |
| GO:BP | GO:0090090 | negative regulation of canonical Wnt signaling pathway | 76 | 109 | 1.41e-03 |
| GO:BP | GO:0003300 | cardiac muscle hypertrophy | 54 | 73 | 1.42e-03 |
| GO:BP | GO:0002764 | immune response-regulating signaling pathway | 168 | 268 | 1.43e-03 |
| GO:BP | GO:0052547 | regulation of peptidase activity | 113 | 172 | 1.53e-03 |
| GO:BP | GO:0008154 | actin polymerization or depolymerization | 99 | 148 | 1.53e-03 |
| GO:BP | GO:0071559 | response to transforming growth factor beta | 140 | 219 | 1.56e-03 |
| GO:BP | GO:0051049 | regulation of transport | 618 | 1098 | 1.65e-03 |
| GO:BP | GO:0002757 | immune response-activating signaling pathway | 162 | 258 | 1.69e-03 |
| GO:BP | GO:0032101 | regulation of response to external stimulus | 380 | 654 | 1.70e-03 |
| GO:BP | GO:1901201 | regulation of extracellular matrix assembly | 18 | 19 | 1.74e-03 |
| GO:BP | GO:0014896 | muscle hypertrophy | 55 | 75 | 1.78e-03 |
| GO:BP | GO:0034109 | homotypic cell-cell adhesion | 50 | 67 | 1.80e-03 |
| GO:BP | GO:0030832 | regulation of actin filament length | 81 | 118 | 1.85e-03 |
| GO:BP | GO:0080135 | regulation of cellular response to stress | 263 | 440 | 1.90e-03 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | 173 | 278 | 1.91e-03 |
| GO:BP | GO:0140747 | regulation of ncRNA transcription | 58 | 80 | 1.91e-03 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | 373 | 642 | 1.96e-03 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | 156 | 248 | 1.97e-03 |
| GO:BP | GO:0071383 | cellular response to steroid hormone stimulus | 105 | 159 | 1.97e-03 |
| GO:BP | GO:0048384 | retinoic acid receptor signaling pathway | 23 | 26 | 2.02e-03 |
| GO:BP | GO:1903706 | regulation of hemopoiesis | 161 | 257 | 2.04e-03 |
| GO:BP | GO:0033036 | macromolecule localization | 1252 | 2309 | 2.17e-03 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | 162 | 259 | 2.17e-03 |
| GO:BP | GO:0006325 | chromatin organization | 352 | 604 | 2.21e-03 |
| GO:BP | GO:0071560 | cellular response to transforming growth factor beta stimulus | 137 | 215 | 2.23e-03 |
| GO:BP | GO:0061614 | miRNA transcription | 46 | 61 | 2.23e-03 |
| GO:BP | GO:0031669 | cellular response to nutrient levels | 126 | 196 | 2.40e-03 |
| GO:BP | GO:0035967 | cellular response to topologically incorrect protein | 62 | 87 | 2.40e-03 |
| GO:BP | GO:0009887 | animal organ morphogenesis | 389 | 673 | 2.43e-03 |
| GO:BP | GO:0030048 | actin filament-based movement | 74 | 107 | 2.51e-03 |
| GO:BP | GO:0001570 | vasculogenesis | 49 | 66 | 2.54e-03 |
| GO:BP | GO:0030098 | lymphocyte differentiation | 156 | 249 | 2.55e-03 |
| GO:BP | GO:0035303 | regulation of dephosphorylation | 57 | 79 | 2.63e-03 |
| GO:BP | GO:0000165 | MAPK cascade | 297 | 504 | 2.68e-03 |
| GO:BP | GO:0051235 | maintenance of location | 157 | 251 | 2.70e-03 |
| GO:BP | GO:0009611 | response to wounding | 230 | 382 | 2.74e-03 |
| GO:BP | GO:0006338 | chromatin remodeling | 287 | 486 | 2.84e-03 |
| GO:BP | GO:0043433 | negative regulation of DNA-binding transcription factor activity | 72 | 104 | 2.90e-03 |
| GO:BP | GO:0032535 | regulation of cellular component size | 177 | 287 | 2.99e-03 |
| GO:BP | GO:1903902 | positive regulation of viral life cycle | 17 | 18 | 3.00e-03 |
| GO:BP | GO:0042326 | negative regulation of phosphorylation | 150 | 239 | 3.00e-03 |
| GO:BP | GO:0001666 | response to hypoxia | 146 | 232 | 3.05e-03 |
| GO:BP | GO:0051649 | establishment of localization in cell | 862 | 1566 | 3.07e-03 |
| GO:BP | GO:1990845 | adaptive thermogenesis | 82 | 121 | 3.07e-03 |
| GO:BP | GO:0090066 | regulation of anatomical structure size | 228 | 379 | 3.07e-03 |
| GO:BP | GO:1902905 | positive regulation of supramolecular fiber organization | 92 | 138 | 3.07e-03 |
| GO:BP | GO:0009952 | anterior/posterior pattern specification | 82 | 121 | 3.07e-03 |
| GO:BP | GO:0003007 | heart morphogenesis | 138 | 218 | 3.10e-03 |
| GO:BP | GO:0098609 | cell-cell adhesion | 329 | 564 | 3.23e-03 |
| GO:BP | GO:0120161 | regulation of cold-induced thermogenesis | 76 | 111 | 3.23e-03 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | 342 | 588 | 3.23e-03 |
| GO:BP | GO:0010720 | positive regulation of cell development | 189 | 309 | 3.30e-03 |
| GO:BP | GO:0031329 | regulation of cellular catabolic process | 324 | 555 | 3.33e-03 |
| GO:BP | GO:0097581 | lamellipodium organization | 53 | 73 | 3.37e-03 |
| GO:BP | GO:0060341 | regulation of cellular localization | 443 | 776 | 3.47e-03 |
| GO:BP | GO:0030178 | negative regulation of Wnt signaling pathway | 90 | 135 | 3.53e-03 |
| GO:BP | GO:0009790 | embryo development | 467 | 821 | 3.55e-03 |
| GO:BP | GO:0045598 | regulation of fat cell differentiation | 65 | 93 | 3.85e-03 |
| GO:BP | GO:1902904 | negative regulation of supramolecular fiber organization | 84 | 125 | 3.86e-03 |
| GO:BP | GO:0070482 | response to oxygen levels | 164 | 265 | 3.93e-03 |
| GO:BP | GO:0000302 | response to reactive oxygen species | 102 | 156 | 4.01e-03 |
| GO:BP | GO:0003176 | aortic valve development | 30 | 37 | 4.01e-03 |
| GO:BP | GO:0060429 | epithelium development | 451 | 792 | 4.01e-03 |
| GO:BP | GO:0043666 | regulation of phosphoprotein phosphatase activity | 28 | 34 | 4.05e-03 |
| GO:BP | GO:0062197 | cellular response to chemical stress | 156 | 251 | 4.16e-03 |
| GO:BP | GO:0003205 | cardiac chamber development | 99 | 151 | 4.25e-03 |
| GO:BP | GO:0022407 | regulation of cell-cell adhesion | 171 | 278 | 4.40e-03 |
| GO:BP | GO:0070727 | cellular macromolecule localization | 1092 | 2010 | 4.40e-03 |
| GO:BP | GO:0006886 | intracellular protein transport | 342 | 590 | 4.41e-03 |
| GO:BP | GO:0018193 | peptidyl-amino acid modification | 323 | 555 | 4.48e-03 |
| GO:BP | GO:0052548 | regulation of endopeptidase activity | 100 | 153 | 4.64e-03 |
| GO:BP | GO:0009056 | catabolic process | 1052 | 1934 | 4.69e-03 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | 2004 | 3777 | 4.75e-03 |
| GO:BP | GO:0031331 | positive regulation of cellular catabolic process | 168 | 273 | 4.76e-03 |
| GO:BP | GO:0043393 | regulation of protein binding | 76 | 112 | 4.76e-03 |
| GO:BP | GO:0106106 | cold-induced thermogenesis | 76 | 112 | 4.76e-03 |
| GO:BP | GO:0042060 | wound healing | 178 | 291 | 4.85e-03 |
| GO:BP | GO:0051090 | regulation of DNA-binding transcription factor activity | 150 | 241 | 4.87e-03 |
| GO:BP | GO:0030833 | regulation of actin filament polymerization | 70 | 102 | 4.98e-03 |
| GO:BP | GO:0005975 | carbohydrate metabolic process | 242 | 407 | 4.98e-03 |
| GO:BP | GO:0030903 | notochord development | 16 | 17 | 5.05e-03 |
| GO:BP | GO:0045321 | leukocyte activation | 309 | 530 | 5.05e-03 |
| GO:BP | GO:0060612 | adipose tissue development | 35 | 45 | 5.05e-03 |
| GO:BP | GO:0060541 | respiratory system development | 105 | 162 | 5.07e-03 |
| GO:BP | GO:0006986 | response to unfolded protein | 80 | 119 | 5.10e-03 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | 117 | 183 | 5.16e-03 |
| GO:BP | GO:2000737 | negative regulation of stem cell differentiation | 21 | 24 | 5.20e-03 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | 2212 | 4185 | 5.27e-03 |
| GO:BP | GO:0007179 | transforming growth factor beta receptor signaling pathway | 110 | 171 | 5.55e-03 |
| GO:BP | GO:0032103 | positive regulation of response to external stimulus | 207 | 344 | 5.57e-03 |
| GO:BP | GO:0050851 | antigen receptor-mediated signaling pathway | 71 | 104 | 5.61e-03 |
| GO:BP | GO:0036294 | cellular response to decreased oxygen levels | 81 | 121 | 5.68e-03 |
| GO:BP | GO:0010464 | regulation of mesenchymal cell proliferation | 23 | 27 | 5.79e-03 |
| GO:BP | GO:0035886 | vascular associated smooth muscle cell differentiation | 23 | 27 | 5.79e-03 |
| GO:BP | GO:0001933 | negative regulation of protein phosphorylation | 140 | 224 | 5.82e-03 |
| GO:BP | GO:0043124 | negative regulation of canonical NF-kappaB signal transduction | 29 | 36 | 5.94e-03 |
| GO:BP | GO:0000768 | syncytium formation by plasma membrane fusion | 29 | 36 | 5.94e-03 |
| GO:BP | GO:0010463 | mesenchymal cell proliferation | 29 | 36 | 5.94e-03 |
| GO:BP | GO:0140253 | cell-cell fusion | 29 | 36 | 5.94e-03 |
| GO:BP | GO:0048008 | platelet-derived growth factor receptor signaling pathway | 38 | 50 | 6.05e-03 |
| GO:BP | GO:0043085 | positive regulation of catalytic activity | 317 | 546 | 6.06e-03 |
| GO:BP | GO:0000209 | protein polyubiquitination | 141 | 226 | 6.11e-03 |
| GO:BP | GO:0045637 | regulation of myeloid cell differentiation | 89 | 135 | 6.23e-03 |
| GO:BP | GO:0031401 | positive regulation of protein modification process | 319 | 550 | 6.36e-03 |
| GO:BP | GO:0097696 | receptor signaling pathway via STAT | 63 | 91 | 6.68e-03 |
| GO:BP | GO:0008104 | protein localization | 1084 | 2000 | 6.74e-03 |
| GO:BP | GO:0007584 | response to nutrient | 76 | 113 | 6.83e-03 |
| GO:BP | GO:0030032 | lamellipodium assembly | 41 | 55 | 6.97e-03 |
| GO:BP | GO:0048193 | Golgi vesicle transport | 162 | 264 | 6.97e-03 |
| GO:BP | GO:0061572 | actin filament bundle organization | 87 | 132 | 7.27e-03 |
| GO:BP | GO:0043244 | regulation of protein-containing complex disassembly | 70 | 103 | 7.32e-03 |
| GO:BP | GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 106 | 165 | 7.36e-03 |
| GO:BP | GO:0031344 | regulation of cell projection organization | 300 | 516 | 7.59e-03 |
| GO:BP | GO:0055006 | cardiac cell development | 55 | 78 | 7.68e-03 |
| GO:BP | GO:0003013 | circulatory system process | 251 | 426 | 7.76e-03 |
| GO:BP | GO:0040013 | negative regulation of locomotion | 150 | 243 | 7.78e-03 |
| GO:BP | GO:0046483 | heterocycle metabolic process | 2265 | 4295 | 7.81e-03 |
| GO:BP | GO:0031396 | regulation of protein ubiquitination | 103 | 160 | 7.87e-03 |
| GO:BP | GO:1905314 | semi-lunar valve development | 32 | 41 | 7.90e-03 |
| GO:BP | GO:0010952 | positive regulation of peptidase activity | 71 | 105 | 8.22e-03 |
| GO:BP | GO:1903580 | positive regulation of ATP metabolic process | 20 | 23 | 8.34e-03 |
| GO:BP | GO:1902894 | negative regulation of miRNA transcription | 20 | 23 | 8.34e-03 |
| GO:BP | GO:0002429 | immune response-activating cell surface receptor signaling pathway | 100 | 155 | 8.42e-03 |
| GO:BP | GO:0072659 | protein localization to plasma membrane | 147 | 238 | 8.42e-03 |
| GO:BP | GO:0006949 | syncytium formation | 30 | 38 | 8.45e-03 |
| GO:BP | GO:0071474 | cellular hyperosmotic response | 15 | 16 | 8.50e-03 |
| GO:BP | GO:1901879 | regulation of protein depolymerization | 50 | 70 | 8.52e-03 |
| GO:BP | GO:0150115 | cell-substrate junction organization | 65 | 95 | 8.61e-03 |
| GO:BP | GO:0090288 | negative regulation of cellular response to growth factor stimulus | 53 | 75 | 8.75e-03 |
| GO:BP | GO:0051017 | actin filament bundle assembly | 86 | 131 | 9.19e-03 |
| GO:BP | GO:0034614 | cellular response to reactive oxygen species | 79 | 119 | 9.31e-03 |
| GO:BP | GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 131 | 210 | 9.50e-03 |
| GO:BP | GO:0045216 | cell-cell junction organization | 98 | 152 | 9.72e-03 |
| GO:BP | GO:0007623 | circadian rhythm | 98 | 152 | 9.72e-03 |
| GO:BP | GO:0033002 | muscle cell proliferation | 98 | 152 | 9.72e-03 |
| GO:BP | GO:0071456 | cellular response to hypoxia | 76 | 114 | 9.74e-03 |
| GO:BP | GO:0046822 | regulation of nucleocytoplasmic transport | 66 | 97 | 9.74e-03 |
| GO:BP | GO:0043086 | negative regulation of catalytic activity | 180 | 298 | 9.76e-03 |
| GO:BP | GO:0030182 | neuron differentiation | 565 | 1014 | 9.82e-03 |
| GO:BP | GO:0098542 | defense response to other organism | 347 | 605 | 9.93e-03 |
| GO:BP | GO:0120035 | regulation of plasma membrane bounded cell projection organization | 293 | 505 | 1.01e-02 |
| GO:BP | GO:0044409 | symbiont entry into host | 73 | 109 | 1.01e-02 |
| GO:BP | GO:2000116 | regulation of cysteine-type endopeptidase activity | 80 | 121 | 1.02e-02 |
| GO:BP | GO:0009267 | cellular response to starvation | 95 | 147 | 1.03e-02 |
| GO:BP | GO:0040007 | growth | 396 | 697 | 1.08e-02 |
| GO:BP | GO:0046777 | protein autophosphorylation | 92 | 142 | 1.11e-02 |
| GO:BP | GO:0043242 | negative regulation of protein-containing complex disassembly | 46 | 64 | 1.12e-02 |
| GO:BP | GO:0051258 | protein polymerization | 139 | 225 | 1.14e-02 |
| GO:BP | GO:1901360 | organic cyclic compound metabolic process | 2346 | 4460 | 1.14e-02 |
| GO:BP | GO:0070935 | 3’-UTR-mediated mRNA stabilization | 17 | 19 | 1.15e-02 |
| GO:BP | GO:0120162 | positive regulation of cold-induced thermogenesis | 49 | 69 | 1.15e-02 |
| GO:BP | GO:0001659 | temperature homeostasis | 85 | 130 | 1.15e-02 |
| GO:BP | GO:0060412 | ventricular septum morphogenesis | 31 | 40 | 1.15e-02 |
| GO:BP | GO:0043500 | muscle adaptation | 61 | 89 | 1.15e-02 |
| GO:BP | GO:0022008 | neurogenesis | 689 | 1251 | 1.18e-02 |
| GO:BP | GO:0007249 | canonical NF-kappaB signal transduction | 140 | 227 | 1.18e-02 |
| GO:BP | GO:1901880 | negative regulation of protein depolymerization | 41 | 56 | 1.20e-02 |
| GO:BP | GO:0060537 | muscle tissue development | 202 | 339 | 1.20e-02 |
| GO:BP | GO:0051058 | negative regulation of small GTPase mediated signal transduction | 36 | 48 | 1.22e-02 |
| GO:BP | GO:0043408 | regulation of MAPK cascade | 250 | 427 | 1.23e-02 |
| GO:BP | GO:0030866 | cortical actin cytoskeleton organization | 29 | 37 | 1.24e-02 |
| GO:BP | GO:0051261 | protein depolymerization | 65 | 96 | 1.26e-02 |
| GO:BP | GO:0048568 | embryonic organ development | 182 | 303 | 1.28e-02 |
| GO:BP | GO:0098781 | ncRNA transcription | 79 | 120 | 1.29e-02 |
| GO:BP | GO:0045639 | positive regulation of myeloid cell differentiation | 47 | 66 | 1.32e-02 |
| GO:BP | GO:0042110 | T cell activation | 183 | 305 | 1.33e-02 |
| GO:BP | GO:0010634 | positive regulation of epithelial cell migration | 83 | 127 | 1.33e-02 |
| GO:BP | GO:0042594 | response to starvation | 111 | 176 | 1.34e-02 |
| GO:BP | GO:0010035 | response to inorganic substance | 223 | 378 | 1.34e-02 |
| GO:BP | GO:0046718 | symbiont entry into host cell | 69 | 103 | 1.35e-02 |
| GO:BP | GO:0030865 | cortical cytoskeleton organization | 34 | 45 | 1.35e-02 |
| GO:BP | GO:0003231 | cardiac ventricle development | 76 | 115 | 1.35e-02 |
| GO:BP | GO:0002831 | regulation of response to biotic stimulus | 184 | 307 | 1.36e-02 |
| GO:BP | GO:1900744 | regulation of p38MAPK cascade | 25 | 31 | 1.37e-02 |
| GO:BP | GO:2000146 | negative regulation of cell motility | 134 | 217 | 1.38e-02 |
| GO:BP | GO:0045981 | positive regulation of nucleotide metabolic process | 21 | 25 | 1.38e-02 |
| GO:BP | GO:0075294 | positive regulation by symbiont of entry into host | 11 | 11 | 1.38e-02 |
| GO:BP | GO:2000629 | negative regulation of miRNA metabolic process | 21 | 25 | 1.38e-02 |
| GO:BP | GO:0046598 | positive regulation of viral entry into host cell | 11 | 11 | 1.38e-02 |
| GO:BP | GO:1900544 | positive regulation of purine nucleotide metabolic process | 21 | 25 | 1.38e-02 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | 125 | 201 | 1.38e-02 |
| GO:BP | GO:0060317 | cardiac epithelial to mesenchymal transition | 23 | 28 | 1.39e-02 |
| GO:BP | GO:0003206 | cardiac chamber morphogenesis | 73 | 110 | 1.40e-02 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | 269 | 463 | 1.41e-02 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | 269 | 463 | 1.41e-02 |
| GO:BP | GO:0030336 | negative regulation of cell migration | 130 | 210 | 1.41e-02 |
| GO:BP | GO:0022411 | cellular component disassembly | 250 | 428 | 1.41e-02 |
| GO:BP | GO:0009755 | hormone-mediated signaling pathway | 88 | 136 | 1.43e-02 |
| GO:BP | GO:0007259 | receptor signaling pathway via JAK-STAT | 60 | 88 | 1.47e-02 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | 60 | 88 | 1.47e-02 |
| GO:BP | GO:0006952 | defense response | 512 | 918 | 1.49e-02 |
| GO:BP | GO:2000630 | positive regulation of miRNA metabolic process | 37 | 50 | 1.49e-02 |
| GO:BP | GO:0048511 | rhythmic process | 136 | 221 | 1.49e-02 |
| GO:BP | GO:0071824 | protein-DNA complex organization | 387 | 683 | 1.49e-02 |
| GO:BP | GO:0030041 | actin filament polymerization | 81 | 124 | 1.49e-02 |
| GO:BP | GO:0010975 | regulation of neuron projection development | 210 | 355 | 1.49e-02 |
| GO:BP | GO:0019915 | lipid storage | 48 | 68 | 1.50e-02 |
| GO:BP | GO:0043502 | regulation of muscle adaptation | 48 | 68 | 1.50e-02 |
| GO:BP | GO:0003158 | endothelium development | 67 | 100 | 1.51e-02 |
| GO:BP | GO:0030856 | regulation of epithelial cell differentiation | 67 | 100 | 1.51e-02 |
| GO:BP | GO:0051495 | positive regulation of cytoskeleton organization | 93 | 145 | 1.54e-02 |
| GO:BP | GO:0031347 | regulation of defense response | 261 | 449 | 1.56e-02 |
| GO:BP | GO:0055082 | intracellular chemical homeostasis | 281 | 486 | 1.57e-02 |
| GO:BP | GO:0008284 | positive regulation of cell population proliferation | 345 | 605 | 1.58e-02 |
| GO:BP | GO:0051145 | smooth muscle cell differentiation | 40 | 55 | 1.59e-02 |
| GO:BP | GO:0016032 | viral process | 195 | 328 | 1.59e-02 |
| GO:BP | GO:0007009 | plasma membrane organization | 71 | 107 | 1.59e-02 |
| GO:BP | GO:0001952 | regulation of cell-matrix adhesion | 61 | 90 | 1.63e-02 |
| GO:BP | GO:0071453 | cellular response to oxygen levels | 86 | 133 | 1.63e-02 |
| GO:BP | GO:0050767 | regulation of neurogenesis | 174 | 290 | 1.65e-02 |
| GO:BP | GO:0071702 | organic substance transport | 933 | 1722 | 1.68e-02 |
| GO:BP | GO:0007159 | leukocyte cell-cell adhesion | 134 | 218 | 1.69e-02 |
| GO:BP | GO:0006725 | cellular aromatic compound metabolic process | 2267 | 4313 | 1.69e-02 |
| GO:BP | GO:0006900 | vesicle budding from membrane | 52 | 75 | 1.74e-02 |
| GO:BP | GO:0085029 | extracellular matrix assembly | 28 | 36 | 1.74e-02 |
| GO:BP | GO:0048660 | regulation of smooth muscle cell proliferation | 65 | 97 | 1.75e-02 |
| GO:BP | GO:0050878 | regulation of body fluid levels | 140 | 229 | 1.78e-02 |
| GO:BP | GO:0006979 | response to oxidative stress | 182 | 305 | 1.80e-02 |
| GO:BP | GO:0001501 | skeletal system development | 205 | 347 | 1.81e-02 |
| GO:BP | GO:0090101 | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 76 | 116 | 1.81e-02 |
| GO:BP | GO:0009057 | macromolecule catabolic process | 598 | 1083 | 1.82e-02 |
| GO:BP | GO:1902895 | positive regulation of miRNA transcription | 33 | 44 | 1.85e-02 |
| GO:BP | GO:1903844 | regulation of cellular response to transforming growth factor beta stimulus | 80 | 123 | 1.85e-02 |
| GO:BP | GO:0038066 | p38MAPK cascade | 33 | 44 | 1.85e-02 |
| GO:BP | GO:0003180 | aortic valve morphogenesis | 26 | 33 | 1.87e-02 |
| GO:BP | GO:0050801 | monoatomic ion homeostasis | 237 | 406 | 1.88e-02 |
| GO:BP | GO:0006402 | mRNA catabolic process | 127 | 206 | 1.89e-02 |
| GO:BP | GO:0010608 | post-transcriptional regulation of gene expression | 264 | 456 | 1.94e-02 |
| GO:BP | GO:0003208 | cardiac ventricle morphogenesis | 44 | 62 | 1.97e-02 |
| GO:BP | GO:0033043 | regulation of organelle organization | 529 | 953 | 1.98e-02 |
| GO:BP | GO:1903828 | negative regulation of protein localization | 101 | 160 | 1.98e-02 |
| GO:BP | GO:0061013 | regulation of mRNA catabolic process | 101 | 160 | 1.98e-02 |
| GO:BP | GO:0043488 | regulation of mRNA stability | 93 | 146 | 2.02e-02 |
| GO:BP | GO:0055080 | monoatomic cation homeostasis | 234 | 401 | 2.05e-02 |
| GO:BP | GO:1904385 | cellular response to angiotensin | 22 | 27 | 2.05e-02 |
| GO:BP | GO:0051098 | regulation of binding | 124 | 201 | 2.05e-02 |
| GO:BP | GO:0043122 | regulation of canonical NF-kappaB signal transduction | 124 | 201 | 2.05e-02 |
| GO:BP | GO:0072538 | T-helper 17 type immune response | 22 | 27 | 2.05e-02 |
| GO:BP | GO:0034655 | nucleobase-containing compound catabolic process | 242 | 416 | 2.13e-02 |
| GO:BP | GO:0097190 | apoptotic signaling pathway | 269 | 466 | 2.16e-02 |
| GO:BP | GO:0051651 | maintenance of location in cell | 107 | 171 | 2.19e-02 |
| GO:BP | GO:0120039 | plasma membrane bounded cell projection morphogenesis | 284 | 494 | 2.22e-02 |
| GO:BP | GO:0048732 | gland development | 183 | 308 | 2.23e-02 |
| GO:BP | GO:0010950 | positive regulation of endopeptidase activity | 64 | 96 | 2.23e-02 |
| GO:BP | GO:0006913 | nucleocytoplasmic transport | 172 | 288 | 2.23e-02 |
| GO:BP | GO:0051169 | nuclear transport | 172 | 288 | 2.23e-02 |
| GO:BP | GO:0031397 | negative regulation of protein ubiquitination | 42 | 59 | 2.25e-02 |
| GO:BP | GO:0035304 | regulation of protein dephosphorylation | 42 | 59 | 2.25e-02 |
| GO:BP | GO:1903708 | positive regulation of hemopoiesis | 75 | 115 | 2.26e-02 |
| GO:BP | GO:1902107 | positive regulation of leukocyte differentiation | 75 | 115 | 2.26e-02 |
| GO:BP | GO:1901203 | positive regulation of extracellular matrix assembly | 13 | 14 | 2.28e-02 |
| GO:BP | GO:1903321 | negative regulation of protein modification by small protein conjugation or removal | 48 | 69 | 2.28e-02 |
| GO:BP | GO:0048858 | cell projection morphogenesis | 286 | 498 | 2.28e-02 |
| GO:BP | GO:0034260 | negative regulation of GTPase activity | 13 | 14 | 2.28e-02 |
| GO:BP | GO:0048667 | cell morphogenesis involved in neuron differentiation | 252 | 435 | 2.28e-02 |
| GO:BP | GO:0017015 | regulation of transforming growth factor beta receptor signaling pathway | 79 | 122 | 2.28e-02 |
| GO:BP | GO:0007267 | cell-cell signaling | 596 | 1082 | 2.35e-02 |
| GO:BP | GO:0034976 | response to endoplasmic reticulum stress | 113 | 182 | 2.35e-02 |
| GO:BP | GO:0044030 | regulation of DNA methylation | 10 | 10 | 2.35e-02 |
| GO:BP | GO:2000479 | regulation of cAMP-dependent protein kinase activity | 10 | 10 | 2.35e-02 |
| GO:BP | GO:0034599 | cellular response to oxidative stress | 123 | 200 | 2.43e-02 |
| GO:BP | GO:0045667 | regulation of osteoblast differentiation | 65 | 98 | 2.44e-02 |
| GO:BP | GO:0051346 | negative regulation of hydrolase activity | 76 | 117 | 2.44e-02 |
| GO:BP | GO:0042113 | B cell activation | 101 | 161 | 2.54e-02 |
| GO:BP | GO:1903320 | regulation of protein modification by small protein conjugation or removal | 124 | 202 | 2.55e-02 |
| GO:BP | GO:0048708 | astrocyte differentiation | 40 | 56 | 2.57e-02 |
| GO:BP | GO:0007517 | muscle organ development | 160 | 267 | 2.57e-02 |
| GO:BP | GO:0030514 | negative regulation of BMP signaling pathway | 32 | 43 | 2.57e-02 |
| GO:BP | GO:0007369 | gastrulation | 89 | 140 | 2.66e-02 |
| GO:BP | GO:0050920 | regulation of chemotaxis | 85 | 133 | 2.67e-02 |
| GO:BP | GO:0048589 | developmental growth | 287 | 501 | 2.67e-02 |
| GO:BP | GO:0002062 | chondrocyte differentiation | 59 | 88 | 2.68e-02 |
| GO:BP | GO:0032386 | regulation of intracellular transport | 135 | 222 | 2.68e-02 |
| GO:BP | GO:0002833 | positive regulation of response to biotic stimulus | 130 | 213 | 2.68e-02 |
| GO:BP | GO:0010632 | regulation of epithelial cell migration | 116 | 188 | 2.73e-02 |
| GO:BP | GO:1903037 | regulation of leukocyte cell-cell adhesion | 121 | 197 | 2.77e-02 |
| GO:BP | GO:0034641 | cellular nitrogen compound metabolic process | 2432 | 4646 | 2.77e-02 |
| GO:BP | GO:0050852 | T cell receptor signaling pathway | 56 | 83 | 2.77e-02 |
| GO:BP | GO:0030162 | regulation of proteolysis | 241 | 416 | 2.77e-02 |
| GO:BP | GO:0008015 | blood circulation | 209 | 357 | 2.77e-02 |
| GO:BP | GO:0043549 | regulation of kinase activity | 209 | 357 | 2.77e-02 |
| GO:BP | GO:0030042 | actin filament depolymerization | 35 | 48 | 2.77e-02 |
| GO:BP | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 35 | 48 | 2.77e-02 |
| GO:BP | GO:0010811 | positive regulation of cell-substrate adhesion | 63 | 95 | 2.79e-02 |
| GO:BP | GO:0071219 | cellular response to molecule of bacterial origin | 74 | 114 | 2.79e-02 |
| GO:BP | GO:0009628 | response to abiotic stimulus | 452 | 811 | 2.80e-02 |
| GO:BP | GO:0003215 | cardiac right ventricle morphogenesis | 15 | 17 | 2.80e-02 |
| GO:BP | GO:0009166 | nucleotide catabolic process | 86 | 135 | 2.81e-02 |
| GO:BP | GO:0007409 | axonogenesis | 198 | 337 | 2.84e-02 |
| GO:BP | GO:0034620 | cellular response to unfolded protein | 53 | 78 | 2.84e-02 |
| GO:BP | GO:0035305 | negative regulation of dephosphorylation | 23 | 29 | 2.86e-02 |
| GO:BP | GO:1990776 | response to angiotensin | 23 | 29 | 2.86e-02 |
| GO:BP | GO:0043542 | endothelial cell migration | 108 | 174 | 2.86e-02 |
| GO:BP | GO:0003279 | cardiac septum development | 67 | 102 | 2.87e-02 |
| GO:BP | GO:0045814 | negative regulation of gene expression, epigenetic | 67 | 102 | 2.87e-02 |
| GO:BP | GO:0048524 | positive regulation of viral process | 38 | 53 | 2.87e-02 |
| GO:BP | GO:0043401 | steroid hormone mediated signaling pathway | 71 | 109 | 2.95e-02 |
| GO:BP | GO:0042176 | regulation of protein catabolic process | 176 | 297 | 2.96e-02 |
| GO:BP | GO:0032880 | regulation of protein localization | 388 | 691 | 2.96e-02 |
| GO:BP | GO:0048710 | regulation of astrocyte differentiation | 17 | 20 | 3.03e-02 |
| GO:BP | GO:0045446 | endothelial cell differentiation | 57 | 85 | 3.03e-02 |
| GO:BP | GO:0001783 | B cell apoptotic process | 17 | 20 | 3.03e-02 |
| GO:BP | GO:0045088 | regulation of innate immune response | 149 | 248 | 3.03e-02 |
| GO:BP | GO:0002053 | positive regulation of mesenchymal cell proliferation | 17 | 20 | 3.03e-02 |
| GO:BP | GO:0019221 | cytokine-mediated signaling pathway | 160 | 268 | 3.03e-02 |
| GO:BP | GO:0046700 | heterocycle catabolic process | 253 | 439 | 3.05e-02 |
| GO:BP | GO:0090077 | foam cell differentiation | 19 | 23 | 3.06e-02 |
| GO:BP | GO:0010742 | macrophage derived foam cell differentiation | 19 | 23 | 3.06e-02 |
| GO:BP | GO:0018209 | peptidyl-serine modification | 105 | 169 | 3.07e-02 |
| GO:BP | GO:0007160 | cell-matrix adhesion | 105 | 169 | 3.07e-02 |
| GO:BP | GO:0009792 | embryo development ending in birth or egg hatching | 297 | 521 | 3.11e-02 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | 472 | 850 | 3.11e-02 |
| GO:BP | GO:0019725 | cellular homeostasis | 320 | 564 | 3.12e-02 |
| GO:BP | GO:1902305 | regulation of sodium ion transmembrane transport | 28 | 37 | 3.13e-02 |
| GO:BP | GO:0009261 | ribonucleotide catabolic process | 72 | 111 | 3.16e-02 |
| GO:BP | GO:0019058 | viral life cycle | 140 | 232 | 3.18e-02 |
| GO:BP | GO:0031333 | negative regulation of protein-containing complex assembly | 76 | 118 | 3.18e-02 |
| GO:BP | GO:0030100 | regulation of endocytosis | 120 | 196 | 3.19e-02 |
| GO:BP | GO:1901575 | organic substance catabolic process | 845 | 1562 | 3.20e-02 |
| GO:BP | GO:0070527 | platelet aggregation | 36 | 50 | 3.25e-02 |
| GO:BP | GO:0010660 | regulation of muscle cell apoptotic process | 36 | 50 | 3.25e-02 |
| GO:BP | GO:0097193 | intrinsic apoptotic signaling pathway | 152 | 254 | 3.33e-02 |
| GO:BP | GO:0006611 | protein export from nucleus | 39 | 55 | 3.35e-02 |
| GO:BP | GO:0009154 | purine ribonucleotide catabolic process | 69 | 106 | 3.36e-02 |
| GO:BP | GO:0043547 | positive regulation of GTPase activity | 73 | 113 | 3.41e-02 |
| GO:BP | GO:0010256 | endomembrane system organization | 273 | 477 | 3.41e-02 |
| GO:BP | GO:0043009 | chordate embryonic development | 289 | 507 | 3.50e-02 |
| GO:BP | GO:0044403 | biological process involved in symbiotic interaction | 127 | 209 | 3.50e-02 |
| GO:BP | GO:0022409 | positive regulation of cell-cell adhesion | 108 | 175 | 3.57e-02 |
| GO:BP | GO:0048659 | smooth muscle cell proliferation | 66 | 101 | 3.58e-02 |
| GO:BP | GO:0001101 | response to acid chemical | 66 | 101 | 3.58e-02 |
| GO:BP | GO:0019439 | aromatic compound catabolic process | 255 | 444 | 3.64e-02 |
| GO:BP | GO:0031623 | receptor internalization | 59 | 89 | 3.67e-02 |
| GO:BP | GO:0048385 | regulation of retinoic acid receptor signaling pathway | 12 | 13 | 3.67e-02 |
| GO:BP | GO:0060841 | venous blood vessel development | 12 | 13 | 3.67e-02 |
| GO:BP | GO:1903729 | regulation of plasma membrane organization | 12 | 13 | 3.67e-02 |
| GO:BP | GO:0140546 | defense response to symbiont | 315 | 556 | 3.67e-02 |
| GO:BP | GO:0003174 | mitral valve development | 12 | 13 | 3.67e-02 |
| GO:BP | GO:0045600 | positive regulation of fat cell differentiation | 34 | 47 | 3.70e-02 |
| GO:BP | GO:0014743 | regulation of muscle hypertrophy | 34 | 47 | 3.70e-02 |
| GO:BP | GO:0055013 | cardiac muscle cell development | 49 | 72 | 3.71e-02 |
| GO:BP | GO:0071229 | cellular response to acid chemical | 49 | 72 | 3.71e-02 |
| GO:BP | GO:0019318 | hexose metabolic process | 109 | 177 | 3.71e-02 |
| GO:BP | GO:0061564 | axon development | 216 | 372 | 3.72e-02 |
| GO:BP | GO:0032984 | protein-containing complex disassembly | 129 | 213 | 3.75e-02 |
| GO:BP | GO:0014706 | striated muscle tissue development | 129 | 213 | 3.75e-02 |
| GO:BP | GO:0018105 | peptidyl-serine phosphorylation | 100 | 161 | 3.75e-02 |
| GO:BP | GO:0031349 | positive regulation of defense response | 156 | 262 | 3.76e-02 |
| GO:BP | GO:0030857 | negative regulation of epithelial cell differentiation | 24 | 31 | 3.77e-02 |
| GO:BP | GO:0060411 | cardiac septum morphogenesis | 46 | 67 | 3.78e-02 |
| GO:BP | GO:0072089 | stem cell proliferation | 56 | 84 | 3.79e-02 |
| GO:BP | GO:1904063 | negative regulation of cation transmembrane transport | 37 | 52 | 3.79e-02 |
| GO:BP | GO:0048545 | response to steroid hormone | 140 | 233 | 3.80e-02 |
| GO:BP | GO:0072331 | signal transduction by p53 class mediator | 96 | 154 | 3.84e-02 |
| GO:BP | GO:0035108 | limb morphogenesis | 71 | 110 | 3.87e-02 |
| GO:BP | GO:0035107 | appendage morphogenesis | 71 | 110 | 3.87e-02 |
| GO:BP | GO:0042330 | taxis | 146 | 244 | 3.87e-02 |
| GO:BP | GO:0006935 | chemotaxis | 146 | 244 | 3.87e-02 |
| GO:BP | GO:0042327 | positive regulation of phosphorylation | 239 | 415 | 3.92e-02 |
| GO:BP | GO:0030163 | protein catabolic process | 440 | 792 | 3.93e-02 |
| GO:BP | GO:0060397 | growth hormone receptor signaling pathway via JAK-STAT | 9 | 9 | 3.93e-02 |
| GO:BP | GO:0090336 | positive regulation of brown fat cell differentiation | 9 | 9 | 3.93e-02 |
| GO:BP | GO:0030038 | contractile actin filament bundle assembly | 60 | 91 | 3.93e-02 |
| GO:BP | GO:0048845 | venous blood vessel morphogenesis | 9 | 9 | 3.93e-02 |
| GO:BP | GO:0043149 | stress fiber assembly | 60 | 91 | 3.93e-02 |
| GO:BP | GO:1901298 | regulation of hydrogen peroxide-mediated programmed cell death | 9 | 9 | 3.93e-02 |
| GO:BP | GO:0001765 | membrane raft assembly | 9 | 9 | 3.93e-02 |
| GO:BP | GO:1901292 | nucleoside phosphate catabolic process | 88 | 140 | 3.97e-02 |
| GO:BP | GO:0033673 | negative regulation of kinase activity | 84 | 133 | 4.03e-02 |
| GO:BP | GO:0003171 | atrioventricular valve development | 22 | 28 | 4.03e-02 |
| GO:BP | GO:0098876 | vesicle-mediated transport to the plasma membrane | 84 | 133 | 4.03e-02 |
| GO:BP | GO:0010591 | regulation of lamellipodium assembly | 22 | 28 | 4.03e-02 |
| GO:BP | GO:0032456 | endocytic recycling | 50 | 74 | 4.06e-02 |
| GO:BP | GO:0055007 | cardiac muscle cell differentiation | 68 | 105 | 4.07e-02 |
| GO:BP | GO:1905039 | carboxylic acid transmembrane transport | 68 | 105 | 4.07e-02 |
| GO:BP | GO:0072523 | purine-containing compound catabolic process | 76 | 119 | 4.10e-02 |
| GO:BP | GO:0034332 | adherens junction organization | 32 | 44 | 4.11e-02 |
| GO:BP | GO:0030217 | T cell differentiation | 112 | 183 | 4.16e-02 |
| GO:BP | GO:0071901 | negative regulation of protein serine/threonine kinase activity | 47 | 69 | 4.19e-02 |
| GO:BP | GO:0032273 | positive regulation of protein polymerization | 47 | 69 | 4.19e-02 |
| GO:BP | GO:0044270 | cellular nitrogen compound catabolic process | 250 | 436 | 4.19e-02 |
| GO:BP | GO:0048644 | muscle organ morphogenesis | 44 | 64 | 4.24e-02 |
| GO:BP | GO:0048812 | neuron projection morphogenesis | 273 | 479 | 4.24e-02 |
| GO:BP | GO:0048662 | negative regulation of smooth muscle cell proliferation | 27 | 36 | 4.24e-02 |
| GO:BP | GO:0048699 | generation of neurons | 589 | 1076 | 4.24e-02 |
| GO:BP | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | 20 | 25 | 4.24e-02 |
| GO:BP | GO:0072111 | cell proliferation involved in kidney development | 14 | 16 | 4.24e-02 |
| GO:BP | GO:0038095 | Fc-epsilon receptor signaling pathway | 14 | 16 | 4.24e-02 |
| GO:BP | GO:0040029 | epigenetic regulation of gene expression | 103 | 167 | 4.24e-02 |
| GO:BP | GO:0032092 | positive regulation of protein binding | 35 | 49 | 4.24e-02 |
| GO:BP | GO:0043069 | negative regulation of programmed cell death | 360 | 642 | 4.24e-02 |
| GO:BP | GO:0071320 | cellular response to cAMP | 27 | 36 | 4.24e-02 |
| GO:BP | GO:0046323 | glucose import | 38 | 54 | 4.29e-02 |
| GO:BP | GO:0005996 | monosaccharide metabolic process | 118 | 194 | 4.29e-02 |
| GO:BP | GO:0048729 | tissue morphogenesis | 259 | 453 | 4.29e-02 |
| GO:BP | GO:0014910 | regulation of smooth muscle cell migration | 38 | 54 | 4.29e-02 |
| GO:BP | GO:0034766 | negative regulation of monoatomic ion transmembrane transport | 41 | 59 | 4.29e-02 |
| GO:BP | GO:0006195 | purine nucleotide catabolic process | 73 | 114 | 4.34e-02 |
| GO:BP | GO:0006006 | glucose metabolic process | 90 | 144 | 4.36e-02 |
| GO:BP | GO:0035767 | endothelial cell chemotaxis | 18 | 22 | 4.42e-02 |
| GO:BP | GO:0018210 | peptidyl-threonine modification | 51 | 76 | 4.45e-02 |
| GO:BP | GO:1990778 | protein localization to cell periphery | 169 | 287 | 4.53e-02 |
| GO:BP | GO:0045862 | positive regulation of proteolysis | 146 | 245 | 4.54e-02 |
| GO:BP | GO:0019722 | calcium-mediated signaling | 78 | 123 | 4.62e-02 |
| GO:BP | GO:0051701 | biological process involved in interaction with host | 91 | 146 | 4.62e-02 |
| GO:BP | GO:1901873 | regulation of post-translational protein modification | 125 | 207 | 4.63e-02 |
| GO:BP | GO:0055085 | transmembrane transport | 507 | 921 | 4.64e-02 |
| GO:BP | GO:0060048 | cardiac muscle contraction | 74 | 116 | 4.65e-02 |
| GO:BP | GO:0001889 | liver development | 70 | 109 | 4.65e-02 |
| GO:BP | GO:0090263 | positive regulation of canonical Wnt signaling pathway | 55 | 83 | 4.67e-02 |
| GO:BP | GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 55 | 83 | 4.67e-02 |
| GO:BP | GO:0001503 | ossification | 177 | 302 | 4.76e-02 |
| GO:BP | GO:0043933 | protein-containing complex organization | 998 | 1863 | 4.82e-02 |
| GO:BP | GO:0035051 | cardiocyte differentiation | 83 | 132 | 4.82e-02 |
| GO:BP | GO:0060350 | endochondral bone morphogenesis | 33 | 46 | 4.83e-02 |
| GO:BP | GO:0010611 | regulation of cardiac muscle hypertrophy | 33 | 46 | 4.83e-02 |
| GO:BP | GO:0010721 | negative regulation of cell development | 111 | 182 | 4.84e-02 |
| GO:BP | GO:0048705 | skeletal system morphogenesis | 92 | 148 | 4.84e-02 |
| GO:BP | GO:0060415 | muscle tissue morphogenesis | 42 | 61 | 4.86e-02 |
| GO:BP | GO:0072091 | regulation of stem cell proliferation | 42 | 61 | 4.86e-02 |
| GO:BP | GO:0050770 | regulation of axonogenesis | 79 | 125 | 4.88e-02 |
| GO:BP | GO:0030510 | regulation of BMP signaling pathway | 52 | 78 | 4.88e-02 |
| GO:BP | GO:0030518 | intracellular steroid hormone receptor signaling pathway | 63 | 97 | 4.91e-02 |
| GO:BP | GO:0071772 | response to BMP | 75 | 118 | 4.92e-02 |
| GO:BP | GO:0071773 | cellular response to BMP stimulus | 75 | 118 | 4.92e-02 |
| GO:BP | GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 67 | 104 | 4.94e-02 |
| GO:BP | GO:0002520 | immune system development | 88 | 141 | 4.94e-02 |
| GO:BP | GO:0002218 | activation of innate immune response | 102 | 166 | 4.97e-02 |
| GO:BP | GO:0043632 | modification-dependent macromolecule catabolic process | 299 | 529 | 4.98e-02 |
NRnomtable_20k_enh %>%
filter(source=="KEGG", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in NR enhancer neargenes_20k") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:00000 | KEGG root term | 2946 | 5451 | 2.10e-09 |
| KEGG | KEGG:04659 | Th17 cell differentiation | 51 | 60 | 4.20e-06 |
| KEGG | KEGG:05200 | Pathways in cancer | 249 | 391 | 9.31e-06 |
| KEGG | KEGG:04510 | Focal adhesion | 114 | 169 | 5.20e-04 |
| KEGG | KEGG:04380 | Osteoclast differentiation | 67 | 92 | 7.50e-04 |
| KEGG | KEGG:04072 | Phospholipase D signaling pathway | 76 | 107 | 7.50e-04 |
| KEGG | KEGG:04931 | Insulin resistance | 66 | 91 | 7.86e-04 |
| KEGG | KEGG:04148 | Efferocytosis | 83 | 120 | 1.15e-03 |
| KEGG | KEGG:04390 | Hippo signaling pathway | 88 | 129 | 1.18e-03 |
| KEGG | KEGG:05135 | Yersinia infection | 75 | 107 | 1.18e-03 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | 54 | 73 | 1.18e-03 |
| KEGG | KEGG:04630 | JAK-STAT signaling pathway | 60 | 83 | 1.30e-03 |
| KEGG | KEGG:04910 | Insulin signaling pathway | 78 | 113 | 1.32e-03 |
| KEGG | KEGG:05131 | Shigellosis | 131 | 204 | 1.32e-03 |
| KEGG | KEGG:04658 | Th1 and Th2 cell differentiation | 39 | 50 | 1.45e-03 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | 70 | 101 | 2.19e-03 |
| KEGG | KEGG:04917 | Prolactin signaling pathway | 41 | 54 | 2.34e-03 |
| KEGG | KEGG:04520 | Adherens junction | 59 | 83 | 2.34e-03 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | 89 | 134 | 2.65e-03 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | 61 | 87 | 2.78e-03 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 105 | 162 | 2.78e-03 |
| KEGG | KEGG:04310 | Wnt signaling pathway | 88 | 133 | 3.05e-03 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | 66 | 96 | 3.46e-03 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | 103 | 160 | 4.09e-03 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | 56 | 80 | 4.20e-03 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | 93 | 143 | 4.20e-03 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | 62 | 90 | 4.20e-03 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | 73 | 109 | 4.75e-03 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | 70 | 104 | 4.81e-03 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | 89 | 137 | 5.21e-03 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | 93 | 144 | 5.21e-03 |
| KEGG | KEGG:04010 | MAPK signaling pathway | 142 | 231 | 5.57e-03 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | 59 | 86 | 5.57e-03 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | 103 | 162 | 5.63e-03 |
| KEGG | KEGG:04934 | Cushing syndrome | 78 | 119 | 6.70e-03 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | 38 | 52 | 7.71e-03 |
| KEGG | KEGG:05132 | Salmonella infection | 124 | 201 | 8.78e-03 |
| KEGG | KEGG:04152 | AMPK signaling pathway | 67 | 101 | 8.92e-03 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | 51 | 74 | 9.41e-03 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | 66 | 100 | 1.13e-02 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | 94 | 149 | 1.16e-02 |
| KEGG | KEGG:04360 | Axon guidance | 97 | 155 | 1.28e-02 |
| KEGG | KEGG:04657 | IL-17 signaling pathway | 39 | 55 | 1.28e-02 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | 105 | 169 | 1.28e-02 |
| KEGG | KEGG:05226 | Gastric cancer | 73 | 113 | 1.28e-02 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | 102 | 164 | 1.28e-02 |
| KEGG | KEGG:03083 | Polycomb repressive complex | 48 | 70 | 1.28e-02 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | 150 | 250 | 1.28e-02 |
| KEGG | KEGG:04217 | Necroptosis | 65 | 99 | 1.28e-02 |
| KEGG | KEGG:04664 | Fc epsilon RI signaling pathway | 31 | 42 | 1.29e-02 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | 90 | 143 | 1.29e-02 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | 49 | 72 | 1.35e-02 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | 56 | 84 | 1.37e-02 |
| KEGG | KEGG:04730 | Long-term depression | 29 | 39 | 1.38e-02 |
| KEGG | KEGG:03082 | ATP-dependent chromatin remodeling | 60 | 91 | 1.39e-02 |
| KEGG | KEGG:04340 | Hedgehog signaling pathway | 35 | 49 | 1.47e-02 |
| KEGG | KEGG:04920 | Adipocytokine signaling pathway | 35 | 49 | 1.47e-02 |
| KEGG | KEGG:05210 | Colorectal cancer | 54 | 81 | 1.47e-02 |
| KEGG | KEGG:04392 | Hippo signaling pathway - multiple species | 20 | 25 | 1.47e-02 |
| KEGG | KEGG:04144 | Endocytosis | 130 | 216 | 1.58e-02 |
| KEGG | KEGG:04014 | Ras signaling pathway | 101 | 164 | 1.64e-02 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | 72 | 113 | 1.81e-02 |
| KEGG | KEGG:05224 | Breast cancer | 72 | 113 | 1.81e-02 |
| KEGG | KEGG:04218 | Cellular senescence | 85 | 136 | 1.81e-02 |
| KEGG | KEGG:04012 | ErbB signaling pathway | 50 | 75 | 1.81e-02 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | 77 | 122 | 1.81e-02 |
| KEGG | KEGG:04150 | mTOR signaling pathway | 81 | 129 | 1.81e-02 |
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | 50 | 75 | 1.81e-02 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | 92 | 149 | 1.96e-02 |
| KEGG | KEGG:05145 | Toxoplasmosis | 48 | 72 | 2.11e-02 |
| KEGG | KEGG:05211 | Renal cell carcinoma | 42 | 62 | 2.30e-02 |
| KEGG | KEGG:04330 | Notch signaling pathway | 36 | 52 | 2.34e-02 |
| KEGG | KEGG:04710 | Circadian rhythm | 22 | 29 | 2.34e-02 |
| KEGG | KEGG:04611 | Platelet activation | 57 | 88 | 2.34e-02 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | 69 | 109 | 2.34e-02 |
| KEGG | KEGG:04022 | cGMP-PKG signaling pathway | 80 | 129 | 2.65e-02 |
| KEGG | KEGG:04068 | FoxO signaling pathway | 67 | 106 | 2.67e-02 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | 66 | 105 | 3.35e-02 |
| KEGG | KEGG:04979 | Cholesterol metabolism | 24 | 33 | 3.63e-02 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | 47 | 72 | 3.66e-02 |
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | 44 | 67 | 3.90e-02 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | 57 | 90 | 4.26e-02 |
| KEGG | KEGG:04070 | Phosphatidylinositol signaling system | 53 | 83 | 4.26e-02 |
| KEGG | KEGG:05161 | Hepatitis B | 77 | 126 | 4.51e-02 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 50 | 78 | 4.51e-02 |
| KEGG | KEGG:05212 | Pancreatic cancer | 46 | 71 | 4.51e-02 |
intersection of EAR_ATAC and RNA-response genes
EAR
# EAR_int_resgenes <- gost(query = int_EAR_n_RNAresp,
# organism = "hsapiens",
# significant = FALSE,
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = background_df$ENTREZID,
# sources=c("GO:BP","KEGG"))
# saveRDS(EAR_int_resgenes,"data/GO_KEGG_analysis/EAR_int_resgenes.RDS")
EAR_int_restable <- EAR_int_resgenes$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
EAR_int_restable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in EAR neargenes intersected with RNA response genes" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0050794 | regulation of cellular process | 1092 | 7153 | 2.38e-13 |
| GO:BP | GO:0065007 | biological regulation | 1165 | 7734 | 2.38e-13 |
| GO:BP | GO:0050789 | regulation of biological process | 1139 | 7516 | 2.38e-13 |
| GO:BP | GO:0032502 | developmental process | 689 | 4179 | 1.08e-11 |
| GO:BP | GO:0050793 | regulation of developmental process | 326 | 1697 | 2.76e-11 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 348 | 1844 | 3.19e-11 |
| GO:BP | GO:0007275 | multicellular organism development | 542 | 3170 | 5.67e-11 |
| GO:BP | GO:0048856 | anatomical structure development | 637 | 3867 | 2.06e-10 |
| GO:BP | GO:0048519 | negative regulation of biological process | 621 | 3764 | 3.20e-10 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 591 | 3550 | 3.20e-10 |
| GO:BP | GO:0048731 | system development | 471 | 2719 | 5.16e-10 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 353 | 1924 | 6.07e-10 |
| GO:BP | GO:0072359 | circulatory system development | 186 | 864 | 6.09e-10 |
| GO:BP | GO:0023052 | signaling | 640 | 3918 | 6.14e-10 |
| GO:BP | GO:0007154 | cell communication | 648 | 3983 | 8.57e-10 |
| GO:BP | GO:0048869 | cellular developmental process | 481 | 2804 | 9.61e-10 |
| GO:BP | GO:0030154 | cell differentiation | 480 | 2803 | 1.30e-09 |
| GO:BP | GO:0007165 | signal transduction | 592 | 3611 | 3.68e-09 |
| GO:BP | GO:0032501 | multicellular organismal process | 715 | 4504 | 3.92e-09 |
| GO:BP | GO:0051716 | cellular response to stimulus | 732 | 4640 | 6.49e-09 |
| GO:BP | GO:0048518 | positive regulation of biological process | 681 | 4301 | 3.47e-08 |
| GO:BP | GO:0014706 | striated muscle tissue development | 63 | 213 | 6.41e-08 |
| GO:BP | GO:0048513 | animal organ development | 353 | 2004 | 7.86e-08 |
| GO:BP | GO:0050896 | response to stimulus | 823 | 5379 | 1.02e-07 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 629 | 3954 | 1.34e-07 |
| GO:BP | GO:0048589 | developmental growth | 114 | 501 | 3.77e-07 |
| GO:BP | GO:0009888 | tissue development | 250 | 1348 | 4.61e-07 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | 58 | 201 | 7.51e-07 |
| GO:BP | GO:0007507 | heart development | 111 | 499 | 2.18e-06 |
| GO:BP | GO:0022008 | neurogenesis | 229 | 1251 | 7.39e-06 |
| GO:BP | GO:0035556 | intracellular signal transduction | 333 | 1951 | 8.53e-06 |
| GO:BP | GO:0007417 | central nervous system development | 141 | 694 | 9.28e-06 |
| GO:BP | GO:0048468 | cell development | 323 | 1886 | 9.64e-06 |
| GO:BP | GO:0051093 | negative regulation of developmental process | 129 | 622 | 1.00e-05 |
| GO:BP | GO:0048699 | generation of neurons | 200 | 1076 | 1.71e-05 |
| GO:BP | GO:0051094 | positive regulation of developmental process | 174 | 913 | 2.23e-05 |
| GO:BP | GO:0030334 | regulation of cell migration | 135 | 668 | 2.23e-05 |
| GO:BP | GO:2000145 | regulation of cell motility | 140 | 700 | 2.38e-05 |
| GO:BP | GO:0016477 | cell migration | 189 | 1011 | 2.40e-05 |
| GO:BP | GO:0009887 | animal organ morphogenesis | 135 | 673 | 3.15e-05 |
| GO:BP | GO:0060537 | muscle tissue development | 79 | 339 | 3.15e-05 |
| GO:BP | GO:0040012 | regulation of locomotion | 142 | 720 | 4.17e-05 |
| GO:BP | GO:0007399 | nervous system development | 302 | 1775 | 4.48e-05 |
| GO:BP | GO:0040007 | growth | 138 | 697 | 4.72e-05 |
| GO:BP | GO:0045444 | fat cell differentiation | 49 | 179 | 4.81e-05 |
| GO:BP | GO:0141124 | intracellular signaling cassette | 233 | 1314 | 5.41e-05 |
| GO:BP | GO:0030900 | forebrain development | 66 | 272 | 6.19e-05 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | 123 | 609 | 6.75e-05 |
| GO:BP | GO:0060419 | heart growth | 26 | 71 | 7.54e-05 |
| GO:BP | GO:0040011 | locomotion | 154 | 805 | 7.54e-05 |
| GO:BP | GO:0060322 | head development | 111 | 539 | 8.85e-05 |
| GO:BP | GO:0035239 | tube morphogenesis | 127 | 638 | 9.12e-05 |
| GO:BP | GO:0007420 | brain development | 104 | 498 | 9.83e-05 |
| GO:BP | GO:0055017 | cardiac muscle tissue growth | 24 | 64 | 1.16e-04 |
| GO:BP | GO:0035295 | tube development | 150 | 787 | 1.23e-04 |
| GO:BP | GO:0010975 | regulation of neuron projection development | 79 | 355 | 1.68e-04 |
| GO:BP | GO:0030182 | neuron differentiation | 184 | 1014 | 1.99e-04 |
| GO:BP | GO:0048638 | regulation of developmental growth | 59 | 243 | 2.03e-04 |
| GO:BP | GO:0009790 | embryo development | 154 | 821 | 2.16e-04 |
| GO:BP | GO:0030029 | actin filament-based process | 125 | 640 | 2.73e-04 |
| GO:BP | GO:0045595 | regulation of cell differentiation | 192 | 1073 | 2.83e-04 |
| GO:BP | GO:0051241 | negative regulation of multicellular organismal process | 135 | 706 | 3.29e-04 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | 173 | 951 | 3.29e-04 |
| GO:BP | GO:0010646 | regulation of cell communication | 391 | 2444 | 3.37e-04 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | 94 | 452 | 3.37e-04 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | 233 | 1354 | 4.01e-04 |
| GO:BP | GO:0048870 | cell motility | 198 | 1120 | 4.05e-04 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | 214 | 1231 | 5.12e-04 |
| GO:BP | GO:0001568 | blood vessel development | 105 | 525 | 5.41e-04 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | 214 | 1234 | 5.91e-04 |
| GO:BP | GO:0001944 | vasculature development | 109 | 552 | 6.36e-04 |
| GO:BP | GO:0009966 | regulation of signal transduction | 349 | 2166 | 6.57e-04 |
| GO:BP | GO:0051173 | positive regulation of nitrogen compound metabolic process | 351 | 2186 | 8.32e-04 |
| GO:BP | GO:0016358 | dendrite development | 46 | 183 | 8.32e-04 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | 153 | 837 | 8.32e-04 |
| GO:BP | GO:0031324 | negative regulation of cellular metabolic process | 315 | 1934 | 8.32e-04 |
| GO:BP | GO:0048666 | neuron development | 153 | 838 | 8.72e-04 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | 412 | 2622 | 9.21e-04 |
| GO:BP | GO:0023051 | regulation of signaling | 386 | 2438 | 9.33e-04 |
| GO:BP | GO:0021537 | telencephalon development | 48 | 195 | 9.33e-04 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 304 | 1862 | 9.38e-04 |
| GO:BP | GO:0008360 | regulation of cell shape | 31 | 106 | 9.48e-04 |
| GO:BP | GO:0031325 | positive regulation of cellular metabolic process | 371 | 2333 | 9.48e-04 |
| GO:BP | GO:0007423 | sensory organ development | 81 | 387 | 9.98e-04 |
| GO:BP | GO:0035265 | organ growth | 35 | 127 | 1.08e-03 |
| GO:BP | GO:0120035 | regulation of plasma membrane bounded cell projection organization | 100 | 505 | 1.14e-03 |
| GO:BP | GO:0044057 | regulation of system process | 80 | 384 | 1.30e-03 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | 263 | 1588 | 1.37e-03 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 381 | 2415 | 1.39e-03 |
| GO:BP | GO:0001764 | neuron migration | 35 | 129 | 1.48e-03 |
| GO:BP | GO:0048568 | embryonic organ development | 66 | 303 | 1.60e-03 |
| GO:BP | GO:0031344 | regulation of cell projection organization | 101 | 516 | 1.60e-03 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | 269 | 1635 | 1.69e-03 |
| GO:BP | GO:0048514 | blood vessel morphogenesis | 90 | 450 | 1.87e-03 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | 314 | 1951 | 1.87e-03 |
| GO:BP | GO:0031327 | negative regulation of cellular biosynthetic process | 267 | 1624 | 1.87e-03 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | 335 | 2100 | 1.95e-03 |
| GO:BP | GO:0031175 | neuron projection development | 136 | 743 | 1.97e-03 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 421 | 2717 | 2.32e-03 |
| GO:BP | GO:0055013 | cardiac muscle cell development | 23 | 72 | 2.32e-03 |
| GO:BP | GO:0086065 | cell communication involved in cardiac conduction | 19 | 54 | 2.50e-03 |
| GO:BP | GO:0065008 | regulation of biological quality | 304 | 1893 | 2.92e-03 |
| GO:BP | GO:0086003 | cardiac muscle cell contraction | 21 | 64 | 3.18e-03 |
| GO:BP | GO:0045598 | regulation of fat cell differentiation | 27 | 93 | 3.21e-03 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | 298 | 1856 | 3.51e-03 |
| GO:BP | GO:0055007 | cardiac muscle cell differentiation | 29 | 105 | 4.58e-03 |
| GO:BP | GO:0022604 | regulation of cell morphogenesis | 45 | 193 | 5.46e-03 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | 178 | 1040 | 5.54e-03 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | 287 | 1791 | 5.60e-03 |
| GO:BP | GO:0031328 | positive regulation of cellular biosynthetic process | 294 | 1841 | 5.76e-03 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 247 | 1514 | 5.93e-03 |
| GO:BP | GO:0048729 | tissue morphogenesis | 88 | 453 | 5.99e-03 |
| GO:BP | GO:0007010 | cytoskeleton organization | 193 | 1146 | 6.67e-03 |
| GO:BP | GO:0060420 | regulation of heart growth | 17 | 49 | 7.05e-03 |
| GO:BP | GO:0086001 | cardiac muscle cell action potential | 20 | 63 | 7.07e-03 |
| GO:BP | GO:0000902 | cell morphogenesis | 128 | 713 | 7.07e-03 |
| GO:BP | GO:0060284 | regulation of cell development | 106 | 570 | 7.07e-03 |
| GO:BP | GO:0043583 | ear development | 37 | 151 | 7.07e-03 |
| GO:BP | GO:0003205 | cardiac chamber development | 37 | 151 | 7.07e-03 |
| GO:BP | GO:0086004 | regulation of cardiac muscle cell contraction | 13 | 32 | 7.07e-03 |
| GO:BP | GO:0048588 | developmental cell growth | 42 | 179 | 7.15e-03 |
| GO:BP | GO:0042221 | response to chemical | 358 | 2304 | 7.50e-03 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 194 | 1157 | 7.50e-03 |
| GO:BP | GO:0050773 | regulation of dendrite development | 23 | 78 | 7.50e-03 |
| GO:BP | GO:0055006 | cardiac cell development | 23 | 78 | 7.50e-03 |
| GO:BP | GO:0021953 | central nervous system neuron differentiation | 27 | 99 | 8.64e-03 |
| GO:BP | GO:0006468 | protein phosphorylation | 164 | 958 | 8.90e-03 |
| GO:BP | GO:0014897 | striated muscle hypertrophy | 22 | 74 | 8.90e-03 |
| GO:BP | GO:0034329 | cell junction assembly | 66 | 323 | 8.90e-03 |
| GO:BP | GO:0048598 | embryonic morphogenesis | 82 | 422 | 8.90e-03 |
| GO:BP | GO:0016043 | cellular component organization | 698 | 4802 | 8.92e-03 |
| GO:BP | GO:0009952 | anterior/posterior pattern specification | 31 | 121 | 9.65e-03 |
| GO:BP | GO:0034330 | cell junction organization | 101 | 545 | 1.03e-02 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | 151 | 874 | 1.03e-02 |
| GO:BP | GO:0014896 | muscle hypertrophy | 22 | 75 | 1.06e-02 |
| GO:BP | GO:0003008 | system process | 190 | 1139 | 1.08e-02 |
| GO:BP | GO:0003007 | heart morphogenesis | 48 | 218 | 1.10e-02 |
| GO:BP | GO:0048839 | inner ear development | 33 | 133 | 1.11e-02 |
| GO:BP | GO:0045668 | negative regulation of osteoblast differentiation | 14 | 38 | 1.14e-02 |
| GO:BP | GO:0065009 | regulation of molecular function | 213 | 1299 | 1.16e-02 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | 179 | 1067 | 1.21e-02 |
| GO:BP | GO:1903243 | negative regulation of cardiac muscle hypertrophy in response to stress | 5 | 6 | 1.21e-02 |
| GO:BP | GO:0010616 | negative regulation of cardiac muscle adaptation | 5 | 6 | 1.21e-02 |
| GO:BP | GO:0040013 | negative regulation of locomotion | 52 | 243 | 1.23e-02 |
| GO:BP | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 11 | 26 | 1.30e-02 |
| GO:BP | GO:0060038 | cardiac muscle cell proliferation | 15 | 43 | 1.31e-02 |
| GO:BP | GO:0016310 | phosphorylation | 190 | 1145 | 1.33e-02 |
| GO:BP | GO:0070252 | actin-mediated cell contraction | 24 | 87 | 1.41e-02 |
| GO:BP | GO:0043367 | CD4-positive, alpha-beta T cell differentiation | 17 | 53 | 1.60e-02 |
| GO:BP | GO:0086091 | regulation of heart rate by cardiac conduction | 13 | 35 | 1.63e-02 |
| GO:BP | GO:0075732 | viral penetration into host nucleus | 4 | 4 | 1.64e-02 |
| GO:BP | GO:0014745 | negative regulation of muscle adaptation | 6 | 9 | 1.65e-02 |
| GO:BP | GO:0055021 | regulation of cardiac muscle tissue growth | 15 | 44 | 1.66e-02 |
| GO:BP | GO:0086002 | cardiac muscle cell action potential involved in contraction | 15 | 44 | 1.66e-02 |
| GO:BP | GO:0060429 | epithelium development | 137 | 792 | 1.67e-02 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 173 | 1035 | 1.67e-02 |
| GO:BP | GO:2000146 | negative regulation of cell motility | 47 | 217 | 1.67e-02 |
| GO:BP | GO:0003013 | circulatory system process | 81 | 426 | 1.67e-02 |
| GO:BP | GO:0060043 | regulation of cardiac muscle cell proliferation | 12 | 31 | 1.67e-02 |
| GO:BP | GO:0003300 | cardiac muscle hypertrophy | 21 | 73 | 1.67e-02 |
| GO:BP | GO:0003231 | cardiac ventricle development | 29 | 115 | 1.70e-02 |
| GO:BP | GO:0051172 | negative regulation of nitrogen compound metabolic process | 259 | 1633 | 1.78e-02 |
| GO:BP | GO:0035051 | cardiocyte differentiation | 32 | 132 | 1.82e-02 |
| GO:BP | GO:0043010 | camera-type eye development | 49 | 230 | 1.82e-02 |
| GO:BP | GO:1903829 | positive regulation of protein localization | 74 | 384 | 1.88e-02 |
| GO:BP | GO:0060560 | developmental growth involved in morphogenesis | 42 | 190 | 2.06e-02 |
| GO:BP | GO:0086066 | atrial cardiac muscle cell to AV node cell communication | 8 | 16 | 2.08e-02 |
| GO:BP | GO:0086026 | atrial cardiac muscle cell to AV node cell signaling | 8 | 16 | 2.08e-02 |
| GO:BP | GO:0086014 | atrial cardiac muscle cell action potential | 8 | 16 | 2.08e-02 |
| GO:BP | GO:0040008 | regulation of growth | 86 | 462 | 2.08e-02 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | 102 | 566 | 2.13e-02 |
| GO:BP | GO:0031345 | negative regulation of cell projection organization | 34 | 145 | 2.23e-02 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | 60 | 300 | 2.33e-02 |
| GO:BP | GO:0014808 | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 11 | 28 | 2.33e-02 |
| GO:BP | GO:1903514 | release of sequestered calcium ion into cytosol by endoplasmic reticulum | 11 | 28 | 2.33e-02 |
| GO:BP | GO:0051171 | regulation of nitrogen compound metabolic process | 573 | 3918 | 2.35e-02 |
| GO:BP | GO:0003012 | muscle system process | 64 | 325 | 2.36e-02 |
| GO:BP | GO:0030336 | negative regulation of cell migration | 45 | 210 | 2.50e-02 |
| GO:BP | GO:0001508 | action potential | 26 | 102 | 2.53e-02 |
| GO:BP | GO:1903115 | regulation of actin filament-based movement | 13 | 37 | 2.53e-02 |
| GO:BP | GO:0031323 | regulation of cellular metabolic process | 615 | 4233 | 2.53e-02 |
| GO:BP | GO:0009214 | cyclic nucleotide catabolic process | 7 | 13 | 2.54e-02 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | 161 | 965 | 2.54e-02 |
| GO:BP | GO:0051960 | regulation of nervous system development | 66 | 339 | 2.58e-02 |
| GO:BP | GO:0050767 | regulation of neurogenesis | 58 | 290 | 2.72e-02 |
| GO:BP | GO:0007416 | synapse assembly | 32 | 136 | 2.81e-02 |
| GO:BP | GO:0048880 | sensory system development | 54 | 266 | 2.83e-02 |
| GO:BP | GO:0008283 | cell population proliferation | 210 | 1306 | 2.87e-02 |
| GO:BP | GO:0001501 | skeletal system development | 67 | 347 | 2.89e-02 |
| GO:BP | GO:0046834 | lipid phosphorylation | 6 | 10 | 2.93e-02 |
| GO:BP | GO:0045600 | positive regulation of fat cell differentiation | 15 | 47 | 2.98e-02 |
| GO:BP | GO:0090257 | regulation of muscle system process | 39 | 177 | 2.98e-02 |
| GO:BP | GO:0086019 | cell-cell signaling involved in cardiac conduction | 11 | 29 | 2.98e-02 |
| GO:BP | GO:0070848 | response to growth factor | 98 | 547 | 2.98e-02 |
| GO:BP | GO:0010977 | negative regulation of neuron projection development | 27 | 109 | 3.00e-02 |
| GO:BP | GO:2001222 | regulation of neuron migration | 13 | 38 | 3.13e-02 |
| GO:BP | GO:0014741 | negative regulation of muscle hypertrophy | 10 | 25 | 3.14e-02 |
| GO:BP | GO:0099536 | synaptic signaling | 88 | 483 | 3.14e-02 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | 613 | 4231 | 3.16e-02 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | 207 | 1289 | 3.16e-02 |
| GO:BP | GO:0007267 | cell-cell signaling | 177 | 1082 | 3.24e-02 |
| GO:BP | GO:0001525 | angiogenesis | 72 | 381 | 3.24e-02 |
| GO:BP | GO:0061061 | muscle structure development | 96 | 536 | 3.24e-02 |
| GO:BP | GO:0003206 | cardiac chamber morphogenesis | 27 | 110 | 3.30e-02 |
| GO:BP | GO:1990830 | cellular response to leukemia inhibitory factor | 22 | 83 | 3.30e-02 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | 161 | 973 | 3.30e-02 |
| GO:BP | GO:0044093 | positive regulation of molecular function | 133 | 783 | 3.33e-02 |
| GO:BP | GO:0001654 | eye development | 53 | 263 | 3.40e-02 |
| GO:BP | GO:0090596 | sensory organ morphogenesis | 38 | 173 | 3.42e-02 |
| GO:BP | GO:0030335 | positive regulation of cell migration | 74 | 395 | 3.44e-02 |
| GO:BP | GO:0060048 | cardiac muscle contraction | 28 | 116 | 3.45e-02 |
| GO:BP | GO:0008015 | blood circulation | 68 | 357 | 3.45e-02 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 121 | 704 | 3.53e-02 |
| GO:BP | GO:0150063 | visual system development | 53 | 264 | 3.62e-02 |
| GO:BP | GO:0099537 | trans-synaptic signaling | 85 | 467 | 3.64e-02 |
| GO:BP | GO:0001503 | ossification | 59 | 302 | 3.85e-02 |
| GO:BP | GO:0009792 | embryo development ending in birth or egg hatching | 93 | 521 | 4.06e-02 |
| GO:BP | GO:0086064 | cell communication by electrical coupling involved in cardiac conduction | 10 | 26 | 4.07e-02 |
| GO:BP | GO:0070372 | regulation of ERK1 and ERK2 cascade | 38 | 175 | 4.07e-02 |
| GO:BP | GO:0019222 | regulation of metabolic process | 661 | 4603 | 4.07e-02 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | 94 | 528 | 4.09e-02 |
| GO:BP | GO:1990823 | response to leukemia inhibitory factor | 22 | 85 | 4.12e-02 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 712 | 4988 | 4.12e-02 |
| GO:BP | GO:0048644 | muscle organ morphogenesis | 18 | 64 | 4.12e-02 |
| GO:BP | GO:0061448 | connective tissue development | 43 | 205 | 4.12e-02 |
| GO:BP | GO:0007268 | chemical synaptic transmission | 84 | 463 | 4.12e-02 |
| GO:BP | GO:0014855 | striated muscle cell proliferation | 17 | 59 | 4.12e-02 |
| GO:BP | GO:0010976 | positive regulation of neuron projection development | 30 | 129 | 4.12e-02 |
| GO:BP | GO:0061337 | cardiac conduction | 22 | 85 | 4.12e-02 |
| GO:BP | GO:0098916 | anterograde trans-synaptic signaling | 84 | 463 | 4.12e-02 |
| GO:BP | GO:0048640 | negative regulation of developmental growth | 22 | 85 | 4.12e-02 |
| GO:BP | GO:0021543 | pallium development | 31 | 135 | 4.15e-02 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | 271 | 1751 | 4.15e-02 |
| GO:BP | GO:0045637 | regulation of myeloid cell differentiation | 31 | 135 | 4.15e-02 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | 276 | 1787 | 4.16e-02 |
| GO:BP | GO:0030048 | actin filament-based movement | 26 | 107 | 4.16e-02 |
| GO:BP | GO:0010629 | negative regulation of gene expression | 133 | 790 | 4.16e-02 |
| GO:BP | GO:0007389 | pattern specification process | 56 | 286 | 4.39e-02 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 192 | 1197 | 4.40e-02 |
| GO:BP | GO:0044773 | mitotic DNA damage checkpoint signaling | 20 | 75 | 4.40e-02 |
| GO:BP | GO:0043584 | nose development | 6 | 11 | 4.42e-02 |
| GO:BP | GO:0002251 | organ or tissue specific immune response | 6 | 11 | 4.42e-02 |
| GO:BP | GO:0070296 | sarcoplasmic reticulum calcium ion transport | 11 | 31 | 4.42e-02 |
| GO:BP | GO:0046620 | regulation of organ growth | 19 | 70 | 4.42e-02 |
| GO:BP | GO:0071878 | negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway | 4 | 5 | 4.42e-02 |
| GO:BP | GO:0016079 | synaptic vesicle exocytosis | 19 | 70 | 4.42e-02 |
| GO:BP | GO:0086067 | AV node cell to bundle of His cell communication | 6 | 11 | 4.42e-02 |
| GO:BP | GO:0061351 | neural precursor cell proliferation | 28 | 119 | 4.42e-02 |
| GO:BP | GO:0061644 | protein localization to CENP-A containing chromatin | 4 | 5 | 4.42e-02 |
| GO:BP | GO:0086070 | SA node cell to atrial cardiac muscle cell communication | 6 | 11 | 4.42e-02 |
| GO:BP | GO:0010644 | cell communication by electrical coupling | 11 | 31 | 4.42e-02 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | 103 | 591 | 4.43e-02 |
| GO:BP | GO:0055117 | regulation of cardiac muscle contraction | 18 | 65 | 4.49e-02 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | 397 | 2663 | 4.49e-02 |
| GO:BP | GO:2000147 | positive regulation of cell motility | 75 | 408 | 4.53e-02 |
| GO:BP | GO:0001667 | ameboidal-type cell migration | 65 | 344 | 4.53e-02 |
| GO:BP | GO:0055008 | cardiac muscle tissue morphogenesis | 16 | 55 | 4.57e-02 |
| GO:BP | GO:0021591 | ventricular system development | 10 | 27 | 4.84e-02 |
| GO:BP | GO:0043009 | chordate embryonic development | 90 | 507 | 4.84e-02 |
| GO:BP | GO:0040017 | positive regulation of locomotion | 76 | 416 | 4.94e-02 |
EAR_int_restable %>%
filter(source=="KEGG") %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in EAR neargenes intersected with RNA response genes") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:03013 | Nucleocytoplasmic transport | 23 | 96 | 8.45e-01 |
| KEGG | KEGG:03083 | Polycomb repressive complex | 17 | 70 | 8.45e-01 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | 33 | 162 | 8.45e-01 |
| KEGG | KEGG:04730 | Long-term depression | 10 | 39 | 9.42e-01 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | 24 | 122 | 9.42e-01 |
| KEGG | KEGG:04713 | Circadian entrainment | 15 | 68 | 9.42e-01 |
| KEGG | KEGG:05033 | Nicotine addiction | 4 | 10 | 9.42e-01 |
| KEGG | KEGG:04720 | Long-term potentiation | 12 | 51 | 9.42e-01 |
| KEGG | KEGG:04310 | Wnt signaling pathway | 27 | 133 | 9.42e-01 |
| KEGG | KEGG:00592 | alpha-Linolenic acid metabolism | 4 | 10 | 9.42e-01 |
| KEGG | KEGG:04070 | Phosphatidylinositol signaling system | 18 | 83 | 9.42e-01 |
| KEGG | KEGG:04014 | Ras signaling pathway | 30 | 164 | 9.49e-01 |
| KEGG | KEGG:00564 | Glycerophospholipid metabolism | 15 | 71 | 9.49e-01 |
| KEGG | KEGG:05034 | Alcoholism | 20 | 102 | 9.49e-01 |
| KEGG | KEGG:04925 | Aldosterone synthesis and secretion | 11 | 75 | 1.00e+00 |
| KEGG | KEGG:04924 | Renin secretion | 7 | 50 | 1.00e+00 |
| KEGG | KEGG:04923 | Regulation of lipolysis in adipocytes | 3 | 41 | 1.00e+00 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | 10 | 78 | 1.00e+00 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | 9 | 77 | 1.00e+00 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | 7 | 100 | 1.00e+00 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | 19 | 113 | 1.00e+00 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | 17 | 105 | 1.00e+00 |
| KEGG | KEGG:04918 | Thyroid hormone synthesis | 5 | 53 | 1.00e+00 |
| KEGG | KEGG:04917 | Prolactin signaling pathway | 6 | 54 | 1.00e+00 |
| KEGG | KEGG:04916 | Melanogenesis | 11 | 75 | 1.00e+00 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | 8 | 90 | 1.00e+00 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | 8 | 82 | 1.00e+00 |
| KEGG | KEGG:04913 | Ovarian steroidogenesis | 2 | 26 | 1.00e+00 |
| KEGG | KEGG:04920 | Adipocytokine signaling pathway | 9 | 49 | 1.00e+00 |
| KEGG | KEGG:04927 | Cortisol synthesis and secretion | 6 | 46 | 1.00e+00 |
| KEGG | KEGG:05226 | Gastric cancer | 20 | 113 | 1.00e+00 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 13 | 78 | 1.00e+00 |
| KEGG | KEGG:05323 | Rheumatoid arthritis | 4 | 38 | 1.00e+00 |
| KEGG | KEGG:04966 | Collecting duct acid secretion | 2 | 18 | 1.00e+00 |
| KEGG | KEGG:04964 | Proximal tubule bicarbonate reclamation | 1 | 18 | 1.00e+00 |
| KEGG | KEGG:04962 | Vasopressin-regulated water reabsorption | 1 | 37 | 1.00e+00 |
| KEGG | KEGG:04961 | Endocrine and other factor-regulated calcium reabsorption | 6 | 40 | 1.00e+00 |
| KEGG | KEGG:04960 | Aldosterone-regulated sodium reabsorption | 3 | 24 | 1.00e+00 |
| KEGG | KEGG:04940 | Type I diabetes mellitus | 2 | 7 | 1.00e+00 |
| KEGG | KEGG:04936 | Alcoholic liver disease | 14 | 91 | 1.00e+00 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | 14 | 96 | 1.00e+00 |
| KEGG | KEGG:04934 | Cushing syndrome | 20 | 119 | 1.00e+00 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | 12 | 87 | 1.00e+00 |
| KEGG | KEGG:04932 | Non-alcoholic fatty liver disease | 12 | 126 | 1.00e+00 |
| KEGG | KEGG:04931 | Insulin resistance | 14 | 91 | 1.00e+00 |
| KEGG | KEGG:04930 | Type II diabetes mellitus | 5 | 35 | 1.00e+00 |
| KEGG | KEGG:04929 | GnRH secretion | 6 | 50 | 1.00e+00 |
| KEGG | KEGG:04912 | GnRH signaling pathway | 9 | 74 | 1.00e+00 |
| KEGG | KEGG:04911 | Insulin secretion | 11 | 62 | 1.00e+00 |
| KEGG | KEGG:04910 | Insulin signaling pathway | 17 | 113 | 1.00e+00 |
| KEGG | KEGG:04814 | Motor proteins | 13 | 141 | 1.00e+00 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | 8 | 76 | 1.00e+00 |
| KEGG | KEGG:04668 | TNF signaling pathway | 10 | 83 | 1.00e+00 |
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | 10 | 75 | 1.00e+00 |
| KEGG | KEGG:04664 | Fc epsilon RI signaling pathway | 2 | 42 | 1.00e+00 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | 3 | 52 | 1.00e+00 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | 6 | 84 | 1.00e+00 |
| KEGG | KEGG:04659 | Th17 cell differentiation | 11 | 60 | 1.00e+00 |
| KEGG | KEGG:04658 | Th1 and Th2 cell differentiation | 7 | 50 | 1.00e+00 |
| KEGG | KEGG:04657 | IL-17 signaling pathway | 6 | 55 | 1.00e+00 |
| KEGG | KEGG:04650 | Natural killer cell mediated cytotoxicity | 5 | 53 | 1.00e+00 |
| KEGG | KEGG:04640 | Hematopoietic cell lineage | 5 | 28 | 1.00e+00 |
| KEGG | KEGG:04630 | JAK-STAT signaling pathway | 10 | 83 | 1.00e+00 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | 11 | 74 | 1.00e+00 |
| KEGG | KEGG:05416 | Viral myocarditis | 4 | 36 | 1.00e+00 |
| KEGG | KEGG:04623 | Cytosolic DNA-sensing pathway | 4 | 46 | 1.00e+00 |
| KEGG | KEGG:04672 | Intestinal immune network for IgA production | 1 | 10 | 1.00e+00 |
| KEGG | KEGG:04970 | Salivary secretion | 9 | 54 | 1.00e+00 |
| KEGG | KEGG:04710 | Circadian rhythm | 6 | 29 | 1.00e+00 |
| KEGG | KEGG:04714 | Thermogenesis | 21 | 185 | 1.00e+00 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | 18 | 169 | 1.00e+00 |
| KEGG | KEGG:04750 | Inflammatory mediator regulation of TRP channels | 12 | 72 | 1.00e+00 |
| KEGG | KEGG:04744 | Phototransduction | 3 | 12 | 1.00e+00 |
| KEGG | KEGG:04742 | Taste transduction | 5 | 20 | 1.00e+00 |
| KEGG | KEGG:04740 | Olfactory transduction | 6 | 25 | 1.00e+00 |
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | 11 | 67 | 1.00e+00 |
| KEGG | KEGG:04728 | Dopaminergic synapse | 13 | 97 | 1.00e+00 |
| KEGG | KEGG:04727 | GABAergic synapse | 6 | 52 | 1.00e+00 |
| KEGG | KEGG:04726 | Serotonergic synapse | 10 | 58 | 1.00e+00 |
| KEGG | KEGG:04725 | Cholinergic synapse | 11 | 82 | 1.00e+00 |
| KEGG | KEGG:04724 | Glutamatergic synapse | 10 | 74 | 1.00e+00 |
| KEGG | KEGG:04723 | Retrograde endocannabinoid signaling | 12 | 92 | 1.00e+00 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | 12 | 104 | 1.00e+00 |
| KEGG | KEGG:04721 | Synaptic vesicle cycle | 10 | 49 | 1.00e+00 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | 8 | 82 | 1.00e+00 |
| KEGG | KEGG:05415 | Diabetic cardiomyopathy | 16 | 158 | 1.00e+00 |
| KEGG | KEGG:04971 | Gastric acid secretion | 8 | 51 | 1.00e+00 |
| KEGG | KEGG:04972 | Pancreatic secretion | 9 | 57 | 1.00e+00 |
| KEGG | KEGG:04973 | Carbohydrate digestion and absorption | 1 | 29 | 1.00e+00 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 23 | 162 | 1.00e+00 |
| KEGG | KEGG:05203 | Viral carcinogenesis | 20 | 142 | 1.00e+00 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | 13 | 80 | 1.00e+00 |
| KEGG | KEGG:05200 | Pathways in cancer | 50 | 391 | 1.00e+00 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | 9 | 149 | 1.00e+00 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | 17 | 149 | 1.00e+00 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | 15 | 136 | 1.00e+00 |
| KEGG | KEGG:05168 | Herpes simplex virus 1 infection | 24 | 388 | 1.00e+00 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | 20 | 134 | 1.00e+00 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | 21 | 164 | 1.00e+00 |
| KEGG | KEGG:05165 | Human papillomavirus infection | 28 | 252 | 1.00e+00 |
| KEGG | KEGG:05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 8 | 65 | 1.00e+00 |
| KEGG | KEGG:05164 | Influenza A | 12 | 95 | 1.00e+00 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | 21 | 160 | 1.00e+00 |
| KEGG | KEGG:05162 | Measles | 8 | 85 | 1.00e+00 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | 20 | 144 | 1.00e+00 |
| KEGG | KEGG:05321 | Inflammatory bowel disease | 4 | 20 | 1.00e+00 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | 17 | 132 | 1.00e+00 |
| KEGG | KEGG:05210 | Colorectal cancer | 13 | 81 | 1.00e+00 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | 19 | 137 | 1.00e+00 |
| KEGG | KEGG:05224 | Breast cancer | 16 | 113 | 1.00e+00 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | 10 | 64 | 1.00e+00 |
| KEGG | KEGG:05222 | Small cell lung cancer | 8 | 82 | 1.00e+00 |
| KEGG | KEGG:05221 | Acute myeloid leukemia | 10 | 52 | 1.00e+00 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | 10 | 72 | 1.00e+00 |
| KEGG | KEGG:05219 | Bladder cancer | 4 | 35 | 1.00e+00 |
| KEGG | KEGG:05218 | Melanoma | 9 | 56 | 1.00e+00 |
| KEGG | KEGG:05217 | Basal cell carcinoma | 8 | 48 | 1.00e+00 |
| KEGG | KEGG:05216 | Thyroid cancer | 6 | 33 | 1.00e+00 |
| KEGG | KEGG:05215 | Prostate cancer | 10 | 82 | 1.00e+00 |
| KEGG | KEGG:05214 | Glioma | 10 | 65 | 1.00e+00 |
| KEGG | KEGG:05213 | Endometrial cancer | 8 | 54 | 1.00e+00 |
| KEGG | KEGG:05212 | Pancreatic cancer | 12 | 71 | 1.00e+00 |
| KEGG | KEGG:05211 | Renal cell carcinoma | 9 | 62 | 1.00e+00 |
| KEGG | KEGG:05208 | Chemical carcinogenesis - reactive oxygen species | 10 | 173 | 1.00e+00 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | 2 | 58 | 1.00e+00 |
| KEGG | KEGG:05161 | Hepatitis B | 14 | 126 | 1.00e+00 |
| KEGG | KEGG:05152 | Tuberculosis | 9 | 101 | 1.00e+00 |
| KEGG | KEGG:05030 | Cocaine addiction | 3 | 32 | 1.00e+00 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | 37 | 364 | 1.00e+00 |
| KEGG | KEGG:05020 | Prion disease | 17 | 204 | 1.00e+00 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | 15 | 120 | 1.00e+00 |
| KEGG | KEGG:05016 | Huntington disease | 20 | 246 | 1.00e+00 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | 34 | 291 | 1.00e+00 |
| KEGG | KEGG:05012 | Parkinson disease | 19 | 211 | 1.00e+00 |
| KEGG | KEGG:05010 | Alzheimer disease | 27 | 296 | 1.00e+00 |
| KEGG | KEGG:04979 | Cholesterol metabolism | 4 | 33 | 1.00e+00 |
| KEGG | KEGG:04978 | Mineral absorption | 5 | 38 | 1.00e+00 |
| KEGG | KEGG:04622 | RIG-I-like receptor signaling pathway | 4 | 44 | 1.00e+00 |
| KEGG | KEGG:04977 | Vitamin digestion and absorption | 3 | 13 | 1.00e+00 |
| KEGG | KEGG:04976 | Bile secretion | 6 | 41 | 1.00e+00 |
| KEGG | KEGG:04975 | Fat digestion and absorption | 2 | 18 | 1.00e+00 |
| KEGG | KEGG:04974 | Protein digestion and absorption | 9 | 56 | 1.00e+00 |
| KEGG | KEGG:05031 | Amphetamine addiction | 8 | 45 | 1.00e+00 |
| KEGG | KEGG:05160 | Hepatitis C | 16 | 110 | 1.00e+00 |
| KEGG | KEGG:05032 | Morphine addiction | 11 | 54 | 1.00e+00 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | 10 | 73 | 1.00e+00 |
| KEGG | KEGG:05150 | Staphylococcus aureus infection | 1 | 13 | 1.00e+00 |
| KEGG | KEGG:05146 | Amoebiasis | 1 | 62 | 1.00e+00 |
| KEGG | KEGG:05145 | Toxoplasmosis | 7 | 72 | 1.00e+00 |
| KEGG | KEGG:05144 | Malaria | 1 | 20 | 1.00e+00 |
| KEGG | KEGG:05143 | African trypanosomiasis | 1 | 16 | 1.00e+00 |
| KEGG | KEGG:05142 | Chagas disease | 4 | 72 | 1.00e+00 |
| KEGG | KEGG:05140 | Leishmaniasis | 4 | 38 | 1.00e+00 |
| KEGG | KEGG:05135 | Yersinia infection | 12 | 107 | 1.00e+00 |
| KEGG | KEGG:05134 | Legionellosis | 3 | 34 | 1.00e+00 |
| KEGG | KEGG:05133 | Pertussis | 4 | 42 | 1.00e+00 |
| KEGG | KEGG:05132 | Salmonella infection | 16 | 201 | 1.00e+00 |
| KEGG | KEGG:05131 | Shigellosis | 20 | 204 | 1.00e+00 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | 15 | 143 | 1.00e+00 |
| KEGG | KEGG:05120 | Epithelial cell signaling in Helicobacter pylori infection | 5 | 55 | 1.00e+00 |
| KEGG | KEGG:05110 | Vibrio cholerae infection | 5 | 41 | 1.00e+00 |
| KEGG | KEGG:05322 | Systemic lupus erythematosus | 8 | 44 | 1.00e+00 |
| KEGG | KEGG:04621 | NOD-like receptor signaling pathway | 8 | 109 | 1.00e+00 |
| KEGG | KEGG:04611 | Platelet activation | 13 | 88 | 1.00e+00 |
| KEGG | KEGG:04614 | Renin-angiotensin system | 1 | 10 | 1.00e+00 |
| KEGG | KEGG:00760 | Nicotinate and nicotinamide metabolism | 3 | 28 | 1.00e+00 |
| KEGG | KEGG:00750 | Vitamin B6 metabolism | 1 | 5 | 1.00e+00 |
| KEGG | KEGG:00730 | Thiamine metabolism | 2 | 10 | 1.00e+00 |
| KEGG | KEGG:00670 | One carbon pool by folate | 2 | 18 | 1.00e+00 |
| KEGG | KEGG:00650 | Butanoate metabolism | 2 | 17 | 1.00e+00 |
| KEGG | KEGG:00640 | Propanoate metabolism | 2 | 27 | 1.00e+00 |
| KEGG | KEGG:00630 | Glyoxylate and dicarboxylate metabolism | 2 | 25 | 1.00e+00 |
| KEGG | KEGG:00620 | Pyruvate metabolism | 2 | 31 | 1.00e+00 |
| KEGG | KEGG:00601 | Glycosphingolipid biosynthesis - lacto and neolacto series | 1 | 14 | 1.00e+00 |
| KEGG | KEGG:00600 | Sphingolipid metabolism | 7 | 42 | 1.00e+00 |
| KEGG | KEGG:00591 | Linoleic acid metabolism | 2 | 7 | 1.00e+00 |
| KEGG | KEGG:00590 | Arachidonic acid metabolism | 3 | 25 | 1.00e+00 |
| KEGG | KEGG:00565 | Ether lipid metabolism | 4 | 28 | 1.00e+00 |
| KEGG | KEGG:00563 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 2 | 23 | 1.00e+00 |
| KEGG | KEGG:00562 | Inositol phosphate metabolism | 7 | 60 | 1.00e+00 |
| KEGG | KEGG:00770 | Pantothenate and CoA biosynthesis | 3 | 15 | 1.00e+00 |
| KEGG | KEGG:00785 | Lipoic acid metabolism | 1 | 16 | 1.00e+00 |
| KEGG | KEGG:00790 | Folate biosynthesis | 1 | 18 | 1.00e+00 |
| KEGG | KEGG:00830 | Retinol metabolism | 1 | 14 | 1.00e+00 |
| KEGG | KEGG:01524 | Platinum drug resistance | 5 | 60 | 1.00e+00 |
| KEGG | KEGG:01523 | Antifolate resistance | 4 | 22 | 1.00e+00 |
| KEGG | KEGG:01522 | Endocrine resistance | 9 | 82 | 1.00e+00 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | 14 | 72 | 1.00e+00 |
| KEGG | KEGG:01250 | Biosynthesis of nucleotide sugars | 3 | 34 | 1.00e+00 |
| KEGG | KEGG:01240 | Biosynthesis of cofactors | 11 | 109 | 1.00e+00 |
| KEGG | KEGG:01232 | Nucleotide metabolism | 7 | 65 | 1.00e+00 |
| KEGG | KEGG:00561 | Glycerolipid metabolism | 10 | 44 | 1.00e+00 |
| KEGG | KEGG:01230 | Biosynthesis of amino acids | 5 | 52 | 1.00e+00 |
| KEGG | KEGG:01200 | Carbon metabolism | 6 | 88 | 1.00e+00 |
| KEGG | KEGG:01100 | Metabolic pathways | 119 | 1077 | 1.00e+00 |
| KEGG | KEGG:01040 | Biosynthesis of unsaturated fatty acids | 6 | 23 | 1.00e+00 |
| KEGG | KEGG:00983 | Drug metabolism - other enzymes | 2 | 40 | 1.00e+00 |
| KEGG | KEGG:00970 | Aminoacyl-tRNA biosynthesis | 5 | 42 | 1.00e+00 |
| KEGG | KEGG:00910 | Nitrogen metabolism | 1 | 8 | 1.00e+00 |
| KEGG | KEGG:00900 | Terpenoid backbone biosynthesis | 2 | 21 | 1.00e+00 |
| KEGG | KEGG:01212 | Fatty acid metabolism | 10 | 46 | 1.00e+00 |
| KEGG | KEGG:00534 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin | 4 | 19 | 1.00e+00 |
| KEGG | KEGG:00532 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 2 | 20 | 1.00e+00 |
| KEGG | KEGG:00520 | Amino sugar and nucleotide sugar metabolism | 3 | 44 | 1.00e+00 |
| KEGG | KEGG:00240 | Pyrimidine metabolism | 3 | 44 | 1.00e+00 |
| KEGG | KEGG:00230 | Purine metabolism | 18 | 93 | 1.00e+00 |
| KEGG | KEGG:00220 | Arginine biosynthesis | 1 | 15 | 1.00e+00 |
| KEGG | KEGG:00190 | Oxidative phosphorylation | 6 | 99 | 1.00e+00 |
| KEGG | KEGG:00130 | Ubiquinone and other terpenoid-quinone biosynthesis | 1 | 9 | 1.00e+00 |
| KEGG | KEGG:00071 | Fatty acid degradation | 5 | 31 | 1.00e+00 |
| KEGG | KEGG:00062 | Fatty acid elongation | 3 | 22 | 1.00e+00 |
| KEGG | KEGG:00250 | Alanine, aspartate and glutamate metabolism | 2 | 28 | 1.00e+00 |
| KEGG | KEGG:00061 | Fatty acid biosynthesis | 2 | 9 | 1.00e+00 |
| KEGG | KEGG:00052 | Galactose metabolism | 2 | 21 | 1.00e+00 |
| KEGG | KEGG:00051 | Fructose and mannose metabolism | 2 | 26 | 1.00e+00 |
| KEGG | KEGG:00040 | Pentose and glucuronate interconversions | 1 | 11 | 1.00e+00 |
| KEGG | KEGG:00030 | Pentose phosphate pathway | 4 | 20 | 1.00e+00 |
| KEGG | KEGG:00020 | Citrate cycle (TCA cycle) | 2 | 26 | 1.00e+00 |
| KEGG | KEGG:00010 | Glycolysis / Gluconeogenesis | 3 | 41 | 1.00e+00 |
| KEGG | KEGG:00000 | KEGG root term | 713 | 5451 | 1.00e+00 |
| KEGG | KEGG:00053 | Ascorbate and aldarate metabolism | 1 | 8 | 1.00e+00 |
| KEGG | KEGG:02010 | ABC transporters | 4 | 24 | 1.00e+00 |
| KEGG | KEGG:00260 | Glycine, serine and threonine metabolism | 1 | 26 | 1.00e+00 |
| KEGG | KEGG:00280 | Valine, leucine and isoleucine degradation | 4 | 42 | 1.00e+00 |
| KEGG | KEGG:00515 | Mannose type O-glycan biosynthesis | 1 | 19 | 1.00e+00 |
| KEGG | KEGG:00514 | Other types of O-glycan biosynthesis | 4 | 35 | 1.00e+00 |
| KEGG | KEGG:00513 | Various types of N-glycan biosynthesis | 2 | 37 | 1.00e+00 |
| KEGG | KEGG:00512 | Mucin type O-glycan biosynthesis | 2 | 21 | 1.00e+00 |
| KEGG | KEGG:00511 | Other glycan degradation | 1 | 14 | 1.00e+00 |
| KEGG | KEGG:00510 | N-Glycan biosynthesis | 4 | 49 | 1.00e+00 |
| KEGG | KEGG:00500 | Starch and sucrose metabolism | 2 | 22 | 1.00e+00 |
| KEGG | KEGG:00270 | Cysteine and methionine metabolism | 1 | 37 | 1.00e+00 |
| KEGG | KEGG:00480 | Glutathione metabolism | 2 | 39 | 1.00e+00 |
| KEGG | KEGG:00450 | Selenocompound metabolism | 2 | 14 | 1.00e+00 |
| KEGG | KEGG:00440 | Phosphonate and phosphinate metabolism | 1 | 5 | 1.00e+00 |
| KEGG | KEGG:00410 | beta-Alanine metabolism | 3 | 22 | 1.00e+00 |
| KEGG | KEGG:00380 | Tryptophan metabolism | 1 | 21 | 1.00e+00 |
| KEGG | KEGG:00340 | Histidine metabolism | 1 | 10 | 1.00e+00 |
| KEGG | KEGG:00330 | Arginine and proline metabolism | 5 | 33 | 1.00e+00 |
| KEGG | KEGG:00310 | Lysine degradation | 10 | 56 | 1.00e+00 |
| KEGG | KEGG:00470 | D-Amino acid metabolism | 1 | 4 | 1.00e+00 |
| KEGG | KEGG:04620 | Toll-like receptor signaling pathway | 6 | 60 | 1.00e+00 |
| KEGG | KEGG:03008 | Ribosome biogenesis in eukaryotes | 4 | 65 | 1.00e+00 |
| KEGG | KEGG:03015 | mRNA surveillance pathway | 7 | 80 | 1.00e+00 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | 20 | 124 | 1.00e+00 |
| KEGG | KEGG:04260 | Cardiac muscle contraction | 7 | 63 | 1.00e+00 |
| KEGG | KEGG:04218 | Cellular senescence | 23 | 136 | 1.00e+00 |
| KEGG | KEGG:04217 | Necroptosis | 10 | 99 | 1.00e+00 |
| KEGG | KEGG:04216 | Ferroptosis | 6 | 31 | 1.00e+00 |
| KEGG | KEGG:04213 | Longevity regulating pathway - multiple species | 6 | 50 | 1.00e+00 |
| KEGG | KEGG:04211 | Longevity regulating pathway | 9 | 75 | 1.00e+00 |
| KEGG | KEGG:04210 | Apoptosis | 11 | 112 | 1.00e+00 |
| KEGG | KEGG:04152 | AMPK signaling pathway | 17 | 101 | 1.00e+00 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | 24 | 250 | 1.00e+00 |
| KEGG | KEGG:04150 | mTOR signaling pathway | 16 | 129 | 1.00e+00 |
| KEGG | KEGG:04148 | Efferocytosis | 17 | 120 | 1.00e+00 |
| KEGG | KEGG:04146 | Peroxisome | 5 | 66 | 1.00e+00 |
| KEGG | KEGG:04145 | Phagosome | 6 | 84 | 1.00e+00 |
| KEGG | KEGG:04144 | Endocytosis | 27 | 216 | 1.00e+00 |
| KEGG | KEGG:04270 | Vascular smooth muscle contraction | 13 | 92 | 1.00e+00 |
| KEGG | KEGG:04330 | Notch signaling pathway | 10 | 52 | 1.00e+00 |
| KEGG | KEGG:04340 | Hedgehog signaling pathway | 5 | 49 | 1.00e+00 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | 16 | 90 | 1.00e+00 |
| KEGG | KEGG:04613 | Neutrophil extracellular trap formation | 14 | 89 | 1.00e+00 |
| KEGG | KEGG:04612 | Antigen processing and presentation | 3 | 26 | 1.00e+00 |
| KEGG | KEGG:04610 | Complement and coagulation cascades | 2 | 35 | 1.00e+00 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | 19 | 101 | 1.00e+00 |
| KEGG | KEGG:04540 | Gap junction | 8 | 71 | 1.00e+00 |
| KEGG | KEGG:04530 | Tight junction | 21 | 129 | 1.00e+00 |
| KEGG | KEGG:04520 | Adherens junction | 15 | 83 | 1.00e+00 |
| KEGG | KEGG:04142 | Lysosome | 6 | 109 | 1.00e+00 |
| KEGG | KEGG:04514 | Cell adhesion molecules | 12 | 69 | 1.00e+00 |
| KEGG | KEGG:04510 | Focal adhesion | 18 | 169 | 1.00e+00 |
| KEGG | KEGG:04392 | Hippo signaling pathway - multiple species | 5 | 25 | 1.00e+00 |
| KEGG | KEGG:04390 | Hippo signaling pathway | 24 | 129 | 1.00e+00 |
| KEGG | KEGG:04380 | Osteoclast differentiation | 13 | 92 | 1.00e+00 |
| KEGG | KEGG:04371 | Apelin signaling pathway | 10 | 104 | 1.00e+00 |
| KEGG | KEGG:04370 | VEGF signaling pathway | 3 | 47 | 1.00e+00 |
| KEGG | KEGG:04360 | Axon guidance | 26 | 155 | 1.00e+00 |
| KEGG | KEGG:04512 | ECM-receptor interaction | 4 | 66 | 1.00e+00 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | 12 | 149 | 1.00e+00 |
| KEGG | KEGG:04140 | Autophagy - animal | 14 | 149 | 1.00e+00 |
| KEGG | KEGG:04137 | Mitophagy - animal | 10 | 94 | 1.00e+00 |
| KEGG | KEGG:03460 | Fanconi anemia pathway | 5 | 46 | 1.00e+00 |
| KEGG | KEGG:03450 | Non-homologous end-joining | 2 | 12 | 1.00e+00 |
| KEGG | KEGG:03440 | Homologous recombination | 9 | 38 | 1.00e+00 |
| KEGG | KEGG:03430 | Mismatch repair | 4 | 22 | 1.00e+00 |
| KEGG | KEGG:03420 | Nucleotide excision repair | 5 | 54 | 1.00e+00 |
| KEGG | KEGG:03410 | Base excision repair | 5 | 44 | 1.00e+00 |
| KEGG | KEGG:03320 | PPAR signaling pathway | 10 | 47 | 1.00e+00 |
| KEGG | KEGG:04010 | MAPK signaling pathway | 36 | 231 | 1.00e+00 |
| KEGG | KEGG:03265 | Virion - Ebolavirus and Lyssavirus | 2 | 5 | 1.00e+00 |
| KEGG | KEGG:03082 | ATP-dependent chromatin remodeling | 16 | 91 | 1.00e+00 |
| KEGG | KEGG:03060 | Protein export | 3 | 28 | 1.00e+00 |
| KEGG | KEGG:03050 | Proteasome | 3 | 40 | 1.00e+00 |
| KEGG | KEGG:03040 | Spliceosome | 8 | 124 | 1.00e+00 |
| KEGG | KEGG:03030 | DNA replication | 5 | 34 | 1.00e+00 |
| KEGG | KEGG:03022 | Basal transcription factors | 4 | 33 | 1.00e+00 |
| KEGG | KEGG:03018 | RNA degradation | 6 | 67 | 1.00e+00 |
| KEGG | KEGG:03250 | Viral life cycle - HIV-1 | 6 | 54 | 1.00e+00 |
| KEGG | KEGG:03010 | Ribosome | 4 | 121 | 1.00e+00 |
| KEGG | KEGG:04012 | ErbB signaling pathway | 13 | 75 | 1.00e+00 |
| KEGG | KEGG:04020 | Calcium signaling pathway | 26 | 161 | 1.00e+00 |
| KEGG | KEGG:04136 | Autophagy - other | 3 | 29 | 1.00e+00 |
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | 20 | 127 | 1.00e+00 |
| KEGG | KEGG:04115 | p53 signaling pathway | 7 | 66 | 1.00e+00 |
| KEGG | KEGG:04114 | Oocyte meiosis | 12 | 103 | 1.00e+00 |
| KEGG | KEGG:04110 | Cell cycle | 18 | 146 | 1.00e+00 |
| KEGG | KEGG:04080 | Neuroactive ligand-receptor interaction | 13 | 101 | 1.00e+00 |
| KEGG | KEGG:04072 | Phospholipase D signaling pathway | 18 | 107 | 1.00e+00 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | 19 | 143 | 1.00e+00 |
| KEGG | KEGG:04071 | Sphingolipid signaling pathway | 12 | 103 | 1.00e+00 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | 13 | 86 | 1.00e+00 |
| KEGG | KEGG:04064 | NF-kappa B signaling pathway | 9 | 61 | 1.00e+00 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | 13 | 109 | 1.00e+00 |
| KEGG | KEGG:04061 | Viral protein interaction with cytokine and cytokine receptor | 2 | 19 | 1.00e+00 |
| KEGG | KEGG:04060 | Cytokine-cytokine receptor interaction | 8 | 94 | 1.00e+00 |
| KEGG | KEGG:04024 | cAMP signaling pathway | 24 | 147 | 1.00e+00 |
| KEGG | KEGG:04022 | cGMP-PKG signaling pathway | 20 | 129 | 1.00e+00 |
| KEGG | KEGG:04068 | FoxO signaling pathway | 19 | 106 | 1.00e+00 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | 8 | 109 | 1.00e+00 |
EAR_int_restable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
slice_head(n=10) %>%
mutate(log10_p=(-log(p_value, base=10))) %>%
ggplot(., aes(x=log10_p, y=reorder(term_name, log10_p)))+
geom_col(aes(fill="#F8766D"))+
theme_bw()+
ylab("")+
xlab(paste0("-log10 p-value"))+
guides(fill="none")+
theme(axis.text.y = element_text(color="black"))+
ggtitle("Intersection EAR")
ESR
# ESR_int_resgenes <- gost(query = int_ESR_n_RNAresp,
# organism = "hsapiens",
# significant = FALSE,
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = background_df$ENTREZID,
# sources=c("GO:BP","KEGG"))
# saveRDS(ESR_int_resgenes,"data/GO_KEGG_analysis/ESR_int_resgenes.RDS")
ESR_int_restable <- ESR_int_resgenes$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
ESR_int_restable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in ESR neargenes intersected with RNA response genes" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0032501 | multicellular organismal process | 1141 | 4504 | 9.64e-21 |
| GO:BP | GO:0007275 | multicellular organism development | 845 | 3170 | 7.84e-20 |
| GO:BP | GO:0048856 | anatomical structure development | 995 | 3867 | 2.24e-19 |
| GO:BP | GO:0030154 | cell differentiation | 755 | 2803 | 1.65e-18 |
| GO:BP | GO:0048869 | cellular developmental process | 755 | 2804 | 1.65e-18 |
| GO:BP | GO:0032502 | developmental process | 1056 | 4179 | 1.90e-18 |
| GO:BP | GO:0048731 | system development | 733 | 2719 | 4.74e-18 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 526 | 1844 | 7.62e-17 |
| GO:BP | GO:0007154 | cell communication | 1004 | 3983 | 9.23e-17 |
| GO:BP | GO:0050896 | response to stimulus | 1298 | 5379 | 1.04e-16 |
| GO:BP | GO:0023052 | signaling | 986 | 3918 | 4.09e-16 |
| GO:BP | GO:0051716 | cellular response to stimulus | 1136 | 4640 | 1.80e-15 |
| GO:BP | GO:0009888 | tissue development | 399 | 1348 | 6.29e-15 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 535 | 1924 | 6.66e-15 |
| GO:BP | GO:0007165 | signal transduction | 909 | 3611 | 2.40e-14 |
| GO:BP | GO:0050794 | regulation of cellular process | 1638 | 7153 | 1.22e-13 |
| GO:BP | GO:0048468 | cell development | 519 | 1886 | 1.86e-13 |
| GO:BP | GO:0048513 | animal organ development | 546 | 2004 | 1.94e-13 |
| GO:BP | GO:0050789 | regulation of biological process | 1705 | 7516 | 6.05e-13 |
| GO:BP | GO:0050793 | regulation of developmental process | 471 | 1697 | 1.17e-12 |
| GO:BP | GO:0065007 | biological regulation | 1742 | 7734 | 4.66e-12 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | 261 | 837 | 6.04e-12 |
| GO:BP | GO:0007399 | nervous system development | 485 | 1775 | 7.08e-12 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | 308 | 1040 | 3.45e-11 |
| GO:BP | GO:0022008 | neurogenesis | 356 | 1251 | 1.39e-10 |
| GO:BP | GO:0044057 | regulation of system process | 138 | 384 | 1.96e-10 |
| GO:BP | GO:0072359 | circulatory system development | 261 | 864 | 2.83e-10 |
| GO:BP | GO:0010646 | regulation of cell communication | 627 | 2444 | 3.19e-10 |
| GO:BP | GO:0035239 | tube morphogenesis | 202 | 638 | 1.22e-09 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 951 | 3954 | 1.22e-09 |
| GO:BP | GO:0034330 | cell junction organization | 178 | 545 | 1.29e-09 |
| GO:BP | GO:0023051 | regulation of signaling | 621 | 2438 | 1.64e-09 |
| GO:BP | GO:0035295 | tube development | 237 | 787 | 4.07e-09 |
| GO:BP | GO:0048699 | generation of neurons | 307 | 1076 | 4.07e-09 |
| GO:BP | GO:0048518 | positive regulation of biological process | 1019 | 4301 | 5.72e-09 |
| GO:BP | GO:0051094 | positive regulation of developmental process | 267 | 913 | 5.72e-09 |
| GO:BP | GO:0009887 | animal organ morphogenesis | 208 | 673 | 5.72e-09 |
| GO:BP | GO:0048519 | negative regulation of biological process | 905 | 3764 | 5.74e-09 |
| GO:BP | GO:0003008 | system process | 321 | 1139 | 5.76e-09 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | 276 | 951 | 5.82e-09 |
| GO:BP | GO:0045595 | regulation of cell differentiation | 305 | 1073 | 6.41e-09 |
| GO:BP | GO:0048729 | tissue morphogenesis | 150 | 453 | 1.63e-08 |
| GO:BP | GO:0014706 | striated muscle tissue development | 84 | 213 | 2.40e-08 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 853 | 3550 | 3.57e-08 |
| GO:BP | GO:0030182 | neuron differentiation | 287 | 1014 | 4.07e-08 |
| GO:BP | GO:0009966 | regulation of signal transduction | 550 | 2166 | 5.46e-08 |
| GO:BP | GO:0030029 | actin filament-based process | 195 | 640 | 7.42e-08 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | 466 | 1801 | 1.20e-07 |
| GO:BP | GO:0060562 | epithelial tube morphogenesis | 95 | 261 | 2.15e-07 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 667 | 2717 | 2.15e-07 |
| GO:BP | GO:0048589 | developmental growth | 158 | 501 | 2.42e-07 |
| GO:BP | GO:0007155 | cell adhesion | 265 | 941 | 3.29e-07 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | 180 | 591 | 3.38e-07 |
| GO:BP | GO:0060429 | epithelium development | 229 | 792 | 3.72e-07 |
| GO:BP | GO:0060537 | muscle tissue development | 115 | 339 | 4.53e-07 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | 77 | 201 | 5.26e-07 |
| GO:BP | GO:0016477 | cell migration | 280 | 1011 | 6.19e-07 |
| GO:BP | GO:0051241 | negative regulation of multicellular organismal process | 207 | 706 | 6.21e-07 |
| GO:BP | GO:0031175 | neuron projection development | 216 | 743 | 6.21e-07 |
| GO:BP | GO:0060485 | mesenchyme development | 89 | 245 | 6.61e-07 |
| GO:BP | GO:0048870 | cell motility | 305 | 1120 | 7.20e-07 |
| GO:BP | GO:0035556 | intracellular signal transduction | 494 | 1951 | 7.20e-07 |
| GO:BP | GO:0051093 | negative regulation of developmental process | 186 | 622 | 7.34e-07 |
| GO:BP | GO:0007267 | cell-cell signaling | 296 | 1082 | 7.38e-07 |
| GO:BP | GO:0009790 | embryo development | 234 | 821 | 8.30e-07 |
| GO:BP | GO:0048666 | neuron development | 237 | 838 | 1.37e-06 |
| GO:BP | GO:0031344 | regulation of cell projection organization | 158 | 516 | 1.83e-06 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 471 | 1862 | 1.92e-06 |
| GO:BP | GO:0120035 | regulation of plasma membrane bounded cell projection organization | 155 | 505 | 2.03e-06 |
| GO:BP | GO:0141124 | intracellular signaling cassette | 347 | 1314 | 2.03e-06 |
| GO:BP | GO:0007423 | sensory organ development | 125 | 387 | 2.06e-06 |
| GO:BP | GO:0048568 | embryonic organ development | 103 | 303 | 2.09e-06 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | 175 | 588 | 2.70e-06 |
| GO:BP | GO:0001944 | vasculature development | 166 | 552 | 2.85e-06 |
| GO:BP | GO:0008283 | cell population proliferation | 344 | 1306 | 2.99e-06 |
| GO:BP | GO:0010975 | regulation of neuron projection development | 116 | 355 | 3.09e-06 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | 308 | 1150 | 3.09e-06 |
| GO:BP | GO:0007010 | cytoskeleton organization | 307 | 1146 | 3.12e-06 |
| GO:BP | GO:0030900 | forebrain development | 94 | 272 | 3.27e-06 |
| GO:BP | GO:0003012 | muscle system process | 108 | 325 | 3.35e-06 |
| GO:BP | GO:0060322 | head development | 162 | 539 | 4.04e-06 |
| GO:BP | GO:0007507 | heart development | 152 | 499 | 4.15e-06 |
| GO:BP | GO:0002009 | morphogenesis of an epithelium | 119 | 369 | 4.34e-06 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | 179 | 609 | 4.34e-06 |
| GO:BP | GO:0030030 | cell projection organization | 314 | 1182 | 4.84e-06 |
| GO:BP | GO:0060419 | heart growth | 35 | 71 | 5.56e-06 |
| GO:BP | GO:0090257 | regulation of muscle system process | 67 | 177 | 6.13e-06 |
| GO:BP | GO:0001568 | blood vessel development | 157 | 525 | 8.75e-06 |
| GO:BP | GO:0007417 | central nervous system development | 198 | 694 | 9.01e-06 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | 167 | 566 | 9.01e-06 |
| GO:BP | GO:0035265 | organ growth | 52 | 127 | 9.67e-06 |
| GO:BP | GO:0008016 | regulation of heart contraction | 63 | 165 | 9.92e-06 |
| GO:BP | GO:0050808 | synapse organization | 109 | 337 | 1.23e-05 |
| GO:BP | GO:0021537 | telencephalon development | 71 | 195 | 1.40e-05 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 277 | 1035 | 1.49e-05 |
| GO:BP | GO:0007420 | brain development | 149 | 498 | 1.68e-05 |
| GO:BP | GO:0048598 | embryonic morphogenesis | 130 | 422 | 1.69e-05 |
| GO:BP | GO:0048514 | blood vessel morphogenesis | 137 | 450 | 1.69e-05 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | 284 | 1067 | 1.69e-05 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | 202 | 717 | 1.69e-05 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | 286 | 1077 | 1.85e-05 |
| GO:BP | GO:0061061 | muscle structure development | 158 | 536 | 1.90e-05 |
| GO:BP | GO:0030155 | regulation of cell adhesion | 151 | 508 | 2.01e-05 |
| GO:BP | GO:0060284 | regulation of cell development | 166 | 570 | 2.17e-05 |
| GO:BP | GO:0034329 | cell junction assembly | 104 | 323 | 2.71e-05 |
| GO:BP | GO:0065008 | regulation of biological quality | 468 | 1893 | 3.07e-05 |
| GO:BP | GO:0099537 | trans-synaptic signaling | 140 | 467 | 3.15e-05 |
| GO:BP | GO:0010720 | positive regulation of cell development | 100 | 309 | 3.40e-05 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | 136 | 452 | 3.63e-05 |
| GO:BP | GO:0000902 | cell morphogenesis | 199 | 713 | 3.91e-05 |
| GO:BP | GO:0008015 | blood circulation | 112 | 357 | 3.91e-05 |
| GO:BP | GO:0046632 | alpha-beta T cell differentiation | 33 | 70 | 3.91e-05 |
| GO:BP | GO:0006915 | apoptotic process | 352 | 1377 | 3.91e-05 |
| GO:BP | GO:0055017 | cardiac muscle tissue growth | 31 | 64 | 4.01e-05 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 311 | 1197 | 4.15e-05 |
| GO:BP | GO:0098609 | cell-cell adhesion | 163 | 564 | 4.27e-05 |
| GO:BP | GO:0043009 | chordate embryonic development | 149 | 507 | 4.53e-05 |
| GO:BP | GO:0003013 | circulatory system process | 129 | 426 | 4.56e-05 |
| GO:BP | GO:0099536 | synaptic signaling | 143 | 483 | 4.74e-05 |
| GO:BP | GO:0040011 | locomotion | 220 | 805 | 4.79e-05 |
| GO:BP | GO:0007268 | chemical synaptic transmission | 138 | 463 | 4.79e-05 |
| GO:BP | GO:0009605 | response to external stimulus | 392 | 1559 | 4.79e-05 |
| GO:BP | GO:0098916 | anterograde trans-synaptic signaling | 138 | 463 | 4.79e-05 |
| GO:BP | GO:0032879 | regulation of localization | 365 | 1439 | 4.91e-05 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | 139 | 469 | 6.06e-05 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | 624 | 2622 | 6.06e-05 |
| GO:BP | GO:0031325 | positive regulation of cellular metabolic process | 561 | 2333 | 6.76e-05 |
| GO:BP | GO:0048762 | mesenchymal cell differentiation | 70 | 200 | 7.00e-05 |
| GO:BP | GO:0051960 | regulation of nervous system development | 106 | 339 | 8.29e-05 |
| GO:BP | GO:0009792 | embryo development ending in birth or egg hatching | 151 | 521 | 8.43e-05 |
| GO:BP | GO:0040007 | growth | 193 | 697 | 8.88e-05 |
| GO:BP | GO:0060047 | heart contraction | 68 | 194 | 9.11e-05 |
| GO:BP | GO:0030334 | regulation of cell migration | 186 | 668 | 9.28e-05 |
| GO:BP | GO:0048638 | regulation of developmental growth | 81 | 243 | 9.41e-05 |
| GO:BP | GO:0006937 | regulation of muscle contraction | 49 | 126 | 9.47e-05 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | 257 | 973 | 9.75e-05 |
| GO:BP | GO:0006936 | muscle contraction | 84 | 255 | 1.02e-04 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | 255 | 965 | 1.02e-04 |
| GO:BP | GO:0055001 | muscle cell development | 59 | 163 | 1.33e-04 |
| GO:BP | GO:0008219 | cell death | 358 | 1423 | 1.34e-04 |
| GO:BP | GO:0043010 | camera-type eye development | 77 | 230 | 1.35e-04 |
| GO:BP | GO:0012501 | programmed cell death | 357 | 1419 | 1.36e-04 |
| GO:BP | GO:0002521 | leukocyte differentiation | 113 | 371 | 1.39e-04 |
| GO:BP | GO:0003015 | heart process | 70 | 204 | 1.42e-04 |
| GO:BP | GO:0048880 | sensory system development | 86 | 266 | 1.72e-04 |
| GO:BP | GO:0016043 | cellular component organization | 1079 | 4802 | 1.78e-04 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | 404 | 1635 | 1.84e-04 |
| GO:BP | GO:0001654 | eye development | 85 | 263 | 1.95e-04 |
| GO:BP | GO:0046631 | alpha-beta T cell activation | 37 | 88 | 1.96e-04 |
| GO:BP | GO:0050804 | modulation of chemical synaptic transmission | 100 | 322 | 2.00e-04 |
| GO:BP | GO:0061337 | cardiac conduction | 36 | 85 | 2.14e-04 |
| GO:BP | GO:0003205 | cardiac chamber development | 55 | 151 | 2.15e-04 |
| GO:BP | GO:0040012 | regulation of locomotion | 196 | 720 | 2.16e-04 |
| GO:BP | GO:0150063 | visual system development | 85 | 264 | 2.22e-04 |
| GO:BP | GO:0099177 | regulation of trans-synaptic signaling | 100 | 323 | 2.25e-04 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | 326 | 1289 | 2.28e-04 |
| GO:BP | GO:2000145 | regulation of cell motility | 191 | 700 | 2.40e-04 |
| GO:BP | GO:0042221 | response to chemical | 549 | 2304 | 2.50e-04 |
| GO:BP | GO:0033002 | muscle cell proliferation | 55 | 152 | 2.59e-04 |
| GO:BP | GO:0016310 | phosphorylation | 293 | 1145 | 2.66e-04 |
| GO:BP | GO:0031327 | negative regulation of cellular biosynthetic process | 400 | 1624 | 2.67e-04 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 295 | 1157 | 3.35e-04 |
| GO:BP | GO:1903522 | regulation of blood circulation | 66 | 194 | 3.37e-04 |
| GO:BP | GO:0048167 | regulation of synaptic plasticity | 51 | 139 | 3.52e-04 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | 391 | 1588 | 3.53e-04 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | 450 | 1856 | 3.53e-04 |
| GO:BP | GO:0046637 | regulation of alpha-beta T cell differentiation | 20 | 37 | 3.62e-04 |
| GO:BP | GO:0042692 | muscle cell differentiation | 99 | 323 | 3.76e-04 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | 203 | 757 | 3.83e-04 |
| GO:BP | GO:0051056 | regulation of small GTPase mediated signal transduction | 76 | 233 | 3.83e-04 |
| GO:BP | GO:0071496 | cellular response to external stimulus | 85 | 268 | 3.83e-04 |
| GO:BP | GO:0031644 | regulation of nervous system process | 32 | 74 | 3.83e-04 |
| GO:BP | GO:0001823 | mesonephros development | 32 | 74 | 3.83e-04 |
| GO:BP | GO:0060038 | cardiac muscle cell proliferation | 22 | 43 | 3.94e-04 |
| GO:BP | GO:0099173 | postsynapse organization | 53 | 147 | 3.95e-04 |
| GO:BP | GO:0060420 | regulation of heart growth | 24 | 49 | 4.00e-04 |
| GO:BP | GO:0003231 | cardiac ventricle development | 44 | 115 | 4.06e-04 |
| GO:BP | GO:0006468 | protein phosphorylation | 249 | 958 | 4.06e-04 |
| GO:BP | GO:0045785 | positive regulation of cell adhesion | 93 | 301 | 4.65e-04 |
| GO:BP | GO:1990823 | response to leukemia inhibitory factor | 35 | 85 | 5.22e-04 |
| GO:BP | GO:0051049 | regulation of transport | 280 | 1098 | 5.26e-04 |
| GO:BP | GO:0048858 | cell projection morphogenesis | 141 | 498 | 5.27e-04 |
| GO:BP | GO:0044093 | positive regulation of molecular function | 208 | 783 | 5.27e-04 |
| GO:BP | GO:0014855 | striated muscle cell proliferation | 27 | 59 | 5.27e-04 |
| GO:BP | GO:0001657 | ureteric bud development | 31 | 72 | 5.52e-04 |
| GO:BP | GO:0071363 | cellular response to growth factor stimulus | 148 | 528 | 5.65e-04 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 569 | 2415 | 5.76e-04 |
| GO:BP | GO:0003206 | cardiac chamber morphogenesis | 42 | 110 | 6.50e-04 |
| GO:BP | GO:0042592 | homeostatic process | 288 | 1137 | 6.56e-04 |
| GO:BP | GO:0006941 | striated muscle contraction | 52 | 146 | 6.58e-04 |
| GO:BP | GO:0010647 | positive regulation of cell communication | 306 | 1218 | 6.90e-04 |
| GO:BP | GO:0070848 | response to growth factor | 152 | 547 | 6.93e-04 |
| GO:BP | GO:0003007 | heart morphogenesis | 71 | 218 | 7.15e-04 |
| GO:BP | GO:0072163 | mesonephric epithelium development | 31 | 73 | 7.27e-04 |
| GO:BP | GO:1990830 | cellular response to leukemia inhibitory factor | 34 | 83 | 7.27e-04 |
| GO:BP | GO:0042472 | inner ear morphogenesis | 27 | 60 | 7.27e-04 |
| GO:BP | GO:0072164 | mesonephric tubule development | 31 | 73 | 7.27e-04 |
| GO:BP | GO:0048667 | cell morphogenesis involved in neuron differentiation | 125 | 435 | 7.30e-04 |
| GO:BP | GO:0051146 | striated muscle cell differentiation | 75 | 234 | 7.56e-04 |
| GO:BP | GO:0007186 | G protein-coupled receptor signaling pathway | 113 | 386 | 7.56e-04 |
| GO:BP | GO:0051179 | localization | 847 | 3731 | 7.80e-04 |
| GO:BP | GO:0120039 | plasma membrane bounded cell projection morphogenesis | 139 | 494 | 7.82e-04 |
| GO:BP | GO:0046634 | regulation of alpha-beta T cell activation | 25 | 54 | 7.86e-04 |
| GO:BP | GO:0050877 | nervous system process | 164 | 600 | 8.14e-04 |
| GO:BP | GO:0045165 | cell fate commitment | 53 | 151 | 8.14e-04 |
| GO:BP | GO:0016331 | morphogenesis of embryonic epithelium | 45 | 122 | 8.28e-04 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | 86 | 278 | 8.28e-04 |
| GO:BP | GO:0050767 | regulation of neurogenesis | 89 | 290 | 8.31e-04 |
| GO:BP | GO:0048644 | muscle organ morphogenesis | 28 | 64 | 9.04e-04 |
| GO:BP | GO:0001501 | skeletal system development | 103 | 347 | 9.04e-04 |
| GO:BP | GO:0060421 | positive regulation of heart growth | 16 | 28 | 9.73e-04 |
| GO:BP | GO:0031328 | positive regulation of cellular biosynthetic process | 442 | 1841 | 9.80e-04 |
| GO:BP | GO:0001667 | ameboidal-type cell migration | 102 | 344 | 1.03e-03 |
| GO:BP | GO:0060560 | developmental growth involved in morphogenesis | 63 | 190 | 1.04e-03 |
| GO:BP | GO:0001763 | morphogenesis of a branching structure | 51 | 145 | 1.04e-03 |
| GO:BP | GO:1902105 | regulation of leukocyte differentiation | 64 | 194 | 1.06e-03 |
| GO:BP | GO:0009991 | response to extracellular stimulus | 110 | 377 | 1.06e-03 |
| GO:BP | GO:0060043 | regulation of cardiac muscle cell proliferation | 17 | 31 | 1.08e-03 |
| GO:BP | GO:0055008 | cardiac muscle tissue morphogenesis | 25 | 55 | 1.08e-03 |
| GO:BP | GO:0030217 | T cell differentiation | 61 | 183 | 1.13e-03 |
| GO:BP | GO:0030098 | lymphocyte differentiation | 78 | 249 | 1.16e-03 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | 430 | 1791 | 1.24e-03 |
| GO:BP | GO:0050803 | regulation of synapse structure or activity | 59 | 176 | 1.25e-03 |
| GO:BP | GO:0023056 | positive regulation of signaling | 304 | 1221 | 1.35e-03 |
| GO:BP | GO:0048812 | neuron projection morphogenesis | 134 | 479 | 1.35e-03 |
| GO:BP | GO:0007389 | pattern specification process | 87 | 286 | 1.36e-03 |
| GO:BP | GO:0099003 | vesicle-mediated transport in synapse | 57 | 169 | 1.37e-03 |
| GO:BP | GO:0050807 | regulation of synapse organization | 58 | 173 | 1.42e-03 |
| GO:BP | GO:0065009 | regulation of molecular function | 321 | 1299 | 1.47e-03 |
| GO:BP | GO:0097435 | supramolecular fiber organization | 170 | 633 | 1.47e-03 |
| GO:BP | GO:0014032 | neural crest cell development | 29 | 69 | 1.47e-03 |
| GO:BP | GO:0030048 | actin filament-based movement | 40 | 107 | 1.49e-03 |
| GO:BP | GO:0010628 | positive regulation of gene expression | 196 | 746 | 1.55e-03 |
| GO:BP | GO:0043367 | CD4-positive, alpha-beta T cell differentiation | 24 | 53 | 1.58e-03 |
| GO:BP | GO:0097106 | postsynaptic density organization | 16 | 29 | 1.58e-03 |
| GO:BP | GO:0048839 | inner ear development | 47 | 133 | 1.71e-03 |
| GO:BP | GO:0086004 | regulation of cardiac muscle cell contraction | 17 | 32 | 1.72e-03 |
| GO:BP | GO:0048562 | embryonic organ morphogenesis | 60 | 182 | 1.75e-03 |
| GO:BP | GO:0055021 | regulation of cardiac muscle tissue growth | 21 | 44 | 1.80e-03 |
| GO:BP | GO:0070252 | actin-mediated cell contraction | 34 | 87 | 1.92e-03 |
| GO:BP | GO:0048639 | positive regulation of developmental growth | 43 | 119 | 1.92e-03 |
| GO:BP | GO:0046620 | regulation of organ growth | 29 | 70 | 1.93e-03 |
| GO:BP | GO:0031345 | negative regulation of cell projection organization | 50 | 145 | 2.00e-03 |
| GO:BP | GO:0016358 | dendrite development | 60 | 183 | 2.05e-03 |
| GO:BP | GO:0014033 | neural crest cell differentiation | 31 | 77 | 2.05e-03 |
| GO:BP | GO:0048863 | stem cell differentiation | 62 | 191 | 2.14e-03 |
| GO:BP | GO:0086065 | cell communication involved in cardiac conduction | 24 | 54 | 2.18e-03 |
| GO:BP | GO:0022407 | regulation of cell-cell adhesion | 84 | 278 | 2.20e-03 |
| GO:BP | GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 15 | 27 | 2.35e-03 |
| GO:BP | GO:0003338 | metanephros morphogenesis | 12 | 19 | 2.37e-03 |
| GO:BP | GO:0006942 | regulation of striated muscle contraction | 32 | 81 | 2.37e-03 |
| GO:BP | GO:0048565 | digestive tract development | 34 | 88 | 2.40e-03 |
| GO:BP | GO:0048754 | branching morphogenesis of an epithelial tube | 41 | 113 | 2.43e-03 |
| GO:BP | GO:0048771 | tissue remodeling | 41 | 113 | 2.43e-03 |
| GO:BP | GO:0030001 | metal ion transport | 143 | 524 | 2.45e-03 |
| GO:BP | GO:0035148 | tube formation | 44 | 124 | 2.45e-03 |
| GO:BP | GO:0060415 | muscle tissue morphogenesis | 26 | 61 | 2.49e-03 |
| GO:BP | GO:0090596 | sensory organ morphogenesis | 57 | 173 | 2.53e-03 |
| GO:BP | GO:0046635 | positive regulation of alpha-beta T cell activation | 17 | 33 | 2.63e-03 |
| GO:BP | GO:0060443 | mammary gland morphogenesis | 18 | 36 | 2.68e-03 |
| GO:BP | GO:0071310 | cellular response to organic substance | 318 | 1297 | 2.69e-03 |
| GO:BP | GO:0099545 | trans-synaptic signaling by trans-synaptic complex | 6 | 6 | 2.71e-03 |
| GO:BP | GO:0030097 | hemopoiesis | 166 | 624 | 2.74e-03 |
| GO:BP | GO:0043583 | ear development | 51 | 151 | 2.88e-03 |
| GO:BP | GO:0055123 | digestive system development | 36 | 96 | 2.92e-03 |
| GO:BP | GO:0060045 | positive regulation of cardiac muscle cell proliferation | 13 | 22 | 2.92e-03 |
| GO:BP | GO:0061448 | connective tissue development | 65 | 205 | 2.93e-03 |
| GO:BP | GO:0055117 | regulation of cardiac muscle contraction | 27 | 65 | 2.98e-03 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | 245 | 972 | 3.04e-03 |
| GO:BP | GO:0010721 | negative regulation of cell development | 59 | 182 | 3.05e-03 |
| GO:BP | GO:1903706 | regulation of hemopoiesis | 78 | 257 | 3.11e-03 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | 272 | 1093 | 3.12e-03 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 184 | 704 | 3.14e-03 |
| GO:BP | GO:0055013 | cardiac muscle cell development | 29 | 72 | 3.15e-03 |
| GO:BP | GO:0030903 | notochord development | 11 | 17 | 3.23e-03 |
| GO:BP | GO:0072073 | kidney epithelium development | 40 | 111 | 3.26e-03 |
| GO:BP | GO:0061564 | axon development | 106 | 372 | 3.28e-03 |
| GO:BP | GO:0055023 | positive regulation of cardiac muscle tissue growth | 14 | 25 | 3.28e-03 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | 294 | 1193 | 3.28e-03 |
| GO:BP | GO:0060603 | mammary gland duct morphogenesis | 14 | 25 | 3.28e-03 |
| GO:BP | GO:0034762 | regulation of transmembrane transport | 88 | 298 | 3.28e-03 |
| GO:BP | GO:0097120 | receptor localization to synapse | 21 | 46 | 3.41e-03 |
| GO:BP | GO:0060350 | endochondral bone morphogenesis | 21 | 46 | 3.41e-03 |
| GO:BP | GO:1902107 | positive regulation of leukocyte differentiation | 41 | 115 | 3.41e-03 |
| GO:BP | GO:1903708 | positive regulation of hemopoiesis | 41 | 115 | 3.41e-03 |
| GO:BP | GO:0001525 | angiogenesis | 108 | 381 | 3.47e-03 |
| GO:BP | GO:0071887 | leukocyte apoptotic process | 30 | 76 | 3.55e-03 |
| GO:BP | GO:0048713 | regulation of oligodendrocyte differentiation | 15 | 28 | 3.56e-03 |
| GO:BP | GO:0002027 | regulation of heart rate | 32 | 83 | 3.57e-03 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | 149 | 555 | 3.62e-03 |
| GO:BP | GO:0051173 | positive regulation of nitrogen compound metabolic process | 510 | 2186 | 3.62e-03 |
| GO:BP | GO:0098660 | inorganic ion transmembrane transport | 141 | 521 | 3.68e-03 |
| GO:BP | GO:0010644 | cell communication by electrical coupling | 16 | 31 | 3.70e-03 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | 329 | 1354 | 3.71e-03 |
| GO:BP | GO:0007015 | actin filament organization | 102 | 357 | 3.71e-03 |
| GO:BP | GO:0099084 | postsynaptic specialization organization | 17 | 34 | 3.71e-03 |
| GO:BP | GO:1903115 | regulation of actin filament-based movement | 18 | 37 | 3.71e-03 |
| GO:BP | GO:0030855 | epithelial cell differentiation | 119 | 428 | 3.71e-03 |
| GO:BP | GO:0045321 | leukocyte activation | 143 | 530 | 3.75e-03 |
| GO:BP | GO:0003300 | cardiac muscle hypertrophy | 29 | 73 | 3.84e-03 |
| GO:BP | GO:0031503 | protein-containing complex localization | 52 | 157 | 3.84e-03 |
| GO:BP | GO:0050769 | positive regulation of neurogenesis | 59 | 184 | 3.84e-03 |
| GO:BP | GO:0055007 | cardiac muscle cell differentiation | 38 | 105 | 3.97e-03 |
| GO:BP | GO:0006950 | response to stress | 585 | 2540 | 4.12e-03 |
| GO:BP | GO:0031667 | response to nutrient levels | 101 | 354 | 4.14e-03 |
| GO:BP | GO:0051962 | positive regulation of nervous system development | 66 | 212 | 4.15e-03 |
| GO:BP | GO:0061138 | morphogenesis of a branching epithelium | 46 | 135 | 4.30e-03 |
| GO:BP | GO:0042110 | T cell activation | 89 | 305 | 4.33e-03 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | 415 | 1751 | 4.34e-03 |
| GO:BP | GO:0001775 | cell activation | 165 | 627 | 4.43e-03 |
| GO:BP | GO:1903037 | regulation of leukocyte cell-cell adhesion | 62 | 197 | 4.60e-03 |
| GO:BP | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 125 | 456 | 4.67e-03 |
| GO:BP | GO:0060411 | cardiac septum morphogenesis | 27 | 67 | 4.73e-03 |
| GO:BP | GO:0001838 | embryonic epithelial tube formation | 38 | 106 | 4.81e-03 |
| GO:BP | GO:0048864 | stem cell development | 29 | 74 | 4.84e-03 |
| GO:BP | GO:0014897 | striated muscle hypertrophy | 29 | 74 | 4.84e-03 |
| GO:BP | GO:0042471 | ear morphogenesis | 29 | 74 | 4.84e-03 |
| GO:BP | GO:0099175 | regulation of postsynapse organization | 31 | 81 | 4.85e-03 |
| GO:BP | GO:0046649 | lymphocyte activation | 122 | 444 | 4.90e-03 |
| GO:BP | GO:0031346 | positive regulation of cell projection organization | 84 | 286 | 5.01e-03 |
| GO:BP | GO:0046638 | positive regulation of alpha-beta T cell differentiation | 14 | 26 | 5.03e-03 |
| GO:BP | GO:0086064 | cell communication by electrical coupling involved in cardiac conduction | 14 | 26 | 5.03e-03 |
| GO:BP | GO:0110110 | positive regulation of animal organ morphogenesis | 14 | 26 | 5.03e-03 |
| GO:BP | GO:0086003 | cardiac muscle cell contraction | 26 | 64 | 5.15e-03 |
| GO:BP | GO:0023057 | negative regulation of signaling | 257 | 1036 | 5.15e-03 |
| GO:BP | GO:0006816 | calcium ion transport | 78 | 262 | 5.18e-03 |
| GO:BP | GO:0070588 | calcium ion transmembrane transport | 65 | 210 | 5.24e-03 |
| GO:BP | GO:0007159 | leukocyte cell-cell adhesion | 67 | 218 | 5.25e-03 |
| GO:BP | GO:1902742 | apoptotic process involved in development | 15 | 29 | 5.25e-03 |
| GO:BP | GO:0046622 | positive regulation of organ growth | 17 | 35 | 5.29e-03 |
| GO:BP | GO:0055006 | cardiac cell development | 30 | 78 | 5.34e-03 |
| GO:BP | GO:0048588 | developmental cell growth | 57 | 179 | 5.55e-03 |
| GO:BP | GO:0072132 | mesenchyme morphogenesis | 22 | 51 | 5.59e-03 |
| GO:BP | GO:0021915 | neural tube development | 45 | 133 | 5.59e-03 |
| GO:BP | GO:0030033 | microvillus assembly | 9 | 13 | 5.69e-03 |
| GO:BP | GO:0007517 | muscle organ development | 79 | 267 | 5.69e-03 |
| GO:BP | GO:1901888 | regulation of cell junction assembly | 51 | 156 | 5.70e-03 |
| GO:BP | GO:0007409 | axonogenesis | 96 | 337 | 5.77e-03 |
| GO:BP | GO:0071417 | cellular response to organonitrogen compound | 121 | 442 | 5.79e-03 |
| GO:BP | GO:0010648 | negative regulation of cell communication | 256 | 1034 | 5.80e-03 |
| GO:BP | GO:0040013 | negative regulation of locomotion | 73 | 243 | 5.83e-03 |
| GO:BP | GO:0031668 | cellular response to extracellular stimulus | 67 | 219 | 5.84e-03 |
| GO:BP | GO:0002065 | columnar/cuboidal epithelial cell differentiation | 31 | 82 | 5.84e-03 |
| GO:BP | GO:0014896 | muscle hypertrophy | 29 | 75 | 5.87e-03 |
| GO:BP | GO:0051058 | negative regulation of small GTPase mediated signal transduction | 21 | 48 | 5.92e-03 |
| GO:BP | GO:0042594 | response to starvation | 56 | 176 | 6.18e-03 |
| GO:BP | GO:0050863 | regulation of T cell activation | 63 | 204 | 6.53e-03 |
| GO:BP | GO:0072001 | renal system development | 73 | 244 | 6.53e-03 |
| GO:BP | GO:0042330 | taxis | 73 | 244 | 6.53e-03 |
| GO:BP | GO:0006935 | chemotaxis | 73 | 244 | 6.53e-03 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | 488 | 2100 | 6.53e-03 |
| GO:BP | GO:0032944 | regulation of mononuclear cell proliferation | 41 | 119 | 6.53e-03 |
| GO:BP | GO:0031324 | negative regulation of cellular metabolic process | 452 | 1934 | 6.93e-03 |
| GO:BP | GO:0060348 | bone development | 48 | 146 | 7.12e-03 |
| GO:BP | GO:0060048 | cardiac muscle contraction | 40 | 116 | 7.48e-03 |
| GO:BP | GO:0042391 | regulation of membrane potential | 82 | 282 | 7.65e-03 |
| GO:BP | GO:0003180 | aortic valve morphogenesis | 16 | 33 | 7.77e-03 |
| GO:BP | GO:0086026 | atrial cardiac muscle cell to AV node cell signaling | 10 | 16 | 7.96e-03 |
| GO:BP | GO:0086066 | atrial cardiac muscle cell to AV node cell communication | 10 | 16 | 7.96e-03 |
| GO:BP | GO:0086014 | atrial cardiac muscle cell action potential | 10 | 16 | 7.96e-03 |
| GO:BP | GO:0010977 | negative regulation of neuron projection development | 38 | 109 | 8.05e-03 |
| GO:BP | GO:0035710 | CD4-positive, alpha-beta T cell activation | 26 | 66 | 8.26e-03 |
| GO:BP | GO:0001570 | vasculogenesis | 26 | 66 | 8.26e-03 |
| GO:BP | GO:0060349 | bone morphogenesis | 28 | 73 | 8.31e-03 |
| GO:BP | GO:0099504 | synaptic vesicle cycle | 49 | 151 | 8.47e-03 |
| GO:BP | GO:0003279 | cardiac septum development | 36 | 102 | 8.64e-03 |
| GO:BP | GO:0035051 | cardiocyte differentiation | 44 | 132 | 8.68e-03 |
| GO:BP | GO:0010033 | response to organic substance | 408 | 1736 | 8.79e-03 |
| GO:BP | GO:0072175 | epithelial tube formation | 40 | 117 | 8.81e-03 |
| GO:BP | GO:0007416 | synapse assembly | 45 | 136 | 8.87e-03 |
| GO:BP | GO:0060173 | limb development | 45 | 136 | 8.87e-03 |
| GO:BP | GO:0048736 | appendage development | 45 | 136 | 8.87e-03 |
| GO:BP | GO:0031214 | biomineral tissue development | 37 | 106 | 9.05e-03 |
| GO:BP | GO:0002287 | alpha-beta T cell activation involved in immune response | 19 | 43 | 9.22e-03 |
| GO:BP | GO:0002294 | CD4-positive, alpha-beta T cell differentiation involved in immune response | 19 | 43 | 9.22e-03 |
| GO:BP | GO:0002293 | alpha-beta T cell differentiation involved in immune response | 19 | 43 | 9.22e-03 |
| GO:BP | GO:0042093 | T-helper cell differentiation | 19 | 43 | 9.22e-03 |
| GO:BP | GO:0035108 | limb morphogenesis | 38 | 110 | 9.45e-03 |
| GO:BP | GO:0035107 | appendage morphogenesis | 38 | 110 | 9.45e-03 |
| GO:BP | GO:0002573 | myeloid leukocyte differentiation | 49 | 152 | 9.62e-03 |
| GO:BP | GO:0021953 | central nervous system neuron differentiation | 35 | 99 | 9.62e-03 |
| GO:BP | GO:0045216 | cell-cell junction organization | 49 | 152 | 9.62e-03 |
| GO:BP | GO:0001764 | neuron migration | 43 | 129 | 9.67e-03 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | 128 | 479 | 1.01e-02 |
| GO:BP | GO:0090287 | regulation of cellular response to growth factor stimulus | 73 | 248 | 1.01e-02 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 1091 | 4988 | 1.01e-02 |
| GO:BP | GO:2000181 | negative regulation of blood vessel morphogenesis | 26 | 67 | 1.02e-02 |
| GO:BP | GO:1901343 | negative regulation of vasculature development | 26 | 67 | 1.02e-02 |
| GO:BP | GO:0003151 | outflow tract morphogenesis | 26 | 67 | 1.02e-02 |
| GO:BP | GO:0010629 | negative regulation of gene expression | 199 | 790 | 1.03e-02 |
| GO:BP | GO:0061035 | regulation of cartilage development | 21 | 50 | 1.03e-02 |
| GO:BP | GO:0003148 | outflow tract septum morphogenesis | 12 | 22 | 1.04e-02 |
| GO:BP | GO:0031669 | cellular response to nutrient levels | 60 | 196 | 1.04e-02 |
| GO:BP | GO:0001816 | cytokine production | 119 | 441 | 1.04e-02 |
| GO:BP | GO:1903779 | regulation of cardiac conduction | 12 | 22 | 1.04e-02 |
| GO:BP | GO:0007264 | small GTPase-mediated signal transduction | 107 | 390 | 1.04e-02 |
| GO:BP | GO:0001817 | regulation of cytokine production | 118 | 437 | 1.06e-02 |
| GO:BP | GO:0048640 | negative regulation of developmental growth | 31 | 85 | 1.06e-02 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | 453 | 1951 | 1.09e-02 |
| GO:BP | GO:0060351 | cartilage development involved in endochondral bone morphogenesis | 13 | 25 | 1.09e-02 |
| GO:BP | GO:0021954 | central nervous system neuron development | 23 | 57 | 1.09e-02 |
| GO:BP | GO:0070296 | sarcoplasmic reticulum calcium ion transport | 15 | 31 | 1.10e-02 |
| GO:BP | GO:0031323 | regulation of cellular metabolic process | 934 | 4233 | 1.10e-02 |
| GO:BP | GO:0048483 | autonomic nervous system development | 14 | 28 | 1.11e-02 |
| GO:BP | GO:1903038 | negative regulation of leukocyte cell-cell adhesion | 27 | 71 | 1.12e-02 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | 297 | 1234 | 1.18e-02 |
| GO:BP | GO:0045621 | positive regulation of lymphocyte differentiation | 30 | 82 | 1.19e-02 |
| GO:BP | GO:0019222 | regulation of metabolic process | 1010 | 4603 | 1.21e-02 |
| GO:BP | GO:0055010 | ventricular cardiac muscle tissue morphogenesis | 19 | 44 | 1.21e-02 |
| GO:BP | GO:0022612 | gland morphogenesis | 33 | 93 | 1.21e-02 |
| GO:BP | GO:0045580 | regulation of T cell differentiation | 37 | 108 | 1.24e-02 |
| GO:BP | GO:0042063 | gliogenesis | 71 | 242 | 1.25e-02 |
| GO:BP | GO:0051249 | regulation of lymphocyte activation | 80 | 279 | 1.25e-02 |
| GO:BP | GO:0045619 | regulation of lymphocyte differentiation | 42 | 127 | 1.25e-02 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | 217 | 874 | 1.25e-02 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | 296 | 1231 | 1.25e-02 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | 116 | 431 | 1.28e-02 |
| GO:BP | GO:0050919 | negative chemotaxis | 18 | 41 | 1.30e-02 |
| GO:BP | GO:0006811 | monoatomic ion transport | 182 | 719 | 1.30e-02 |
| GO:BP | GO:0045765 | regulation of angiogenesis | 59 | 194 | 1.31e-02 |
| GO:BP | GO:1901342 | regulation of vasculature development | 60 | 198 | 1.31e-02 |
| GO:BP | GO:0050771 | negative regulation of axonogenesis | 21 | 51 | 1.32e-02 |
| GO:BP | GO:0050670 | regulation of lymphocyte proliferation | 39 | 116 | 1.32e-02 |
| GO:BP | GO:0051235 | maintenance of location | 73 | 251 | 1.34e-02 |
| GO:BP | GO:0051283 | negative regulation of sequestering of calcium ion | 32 | 90 | 1.35e-02 |
| GO:BP | GO:0045582 | positive regulation of T cell differentiation | 27 | 72 | 1.37e-02 |
| GO:BP | GO:0048709 | oligodendrocyte differentiation | 27 | 72 | 1.37e-02 |
| GO:BP | GO:0009267 | cellular response to starvation | 47 | 147 | 1.37e-02 |
| GO:BP | GO:0050865 | regulation of cell activation | 96 | 347 | 1.37e-02 |
| GO:BP | GO:0010959 | regulation of metal ion transport | 70 | 239 | 1.37e-02 |
| GO:BP | GO:0098900 | regulation of action potential | 17 | 38 | 1.37e-02 |
| GO:BP | GO:0030316 | osteoclast differentiation | 25 | 65 | 1.38e-02 |
| GO:BP | GO:0022409 | positive regulation of cell-cell adhesion | 54 | 175 | 1.46e-02 |
| GO:BP | GO:0045444 | fat cell differentiation | 55 | 179 | 1.46e-02 |
| GO:BP | GO:0048486 | parasympathetic nervous system development | 8 | 12 | 1.50e-02 |
| GO:BP | GO:0060561 | apoptotic process involved in morphogenesis | 11 | 20 | 1.50e-02 |
| GO:BP | GO:0032332 | positive regulation of chondrocyte differentiation | 8 | 12 | 1.50e-02 |
| GO:BP | GO:0030879 | mammary gland development | 34 | 98 | 1.50e-02 |
| GO:BP | GO:0014020 | primary neural tube formation | 31 | 87 | 1.51e-02 |
| GO:BP | GO:0007613 | memory | 31 | 87 | 1.51e-02 |
| GO:BP | GO:0003179 | heart valve morphogenesis | 22 | 55 | 1.51e-02 |
| GO:BP | GO:0003281 | ventricular septum development | 26 | 69 | 1.52e-02 |
| GO:BP | GO:0062237 | protein localization to postsynapse | 15 | 32 | 1.52e-02 |
| GO:BP | GO:1903539 | protein localization to postsynaptic membrane | 15 | 32 | 1.52e-02 |
| GO:BP | GO:0050866 | negative regulation of cell activation | 39 | 117 | 1.52e-02 |
| GO:BP | GO:0070167 | regulation of biomineral tissue development | 24 | 62 | 1.53e-02 |
| GO:BP | GO:0002292 | T cell differentiation involved in immune response | 19 | 45 | 1.56e-02 |
| GO:BP | GO:0086019 | cell-cell signaling involved in cardiac conduction | 14 | 29 | 1.57e-02 |
| GO:BP | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 13 | 26 | 1.59e-02 |
| GO:BP | GO:0050770 | regulation of axonogenesis | 41 | 125 | 1.61e-02 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | 436 | 1883 | 1.61e-02 |
| GO:BP | GO:0050806 | positive regulation of synaptic transmission | 36 | 106 | 1.61e-02 |
| GO:BP | GO:0048878 | chemical homeostasis | 170 | 670 | 1.62e-02 |
| GO:BP | GO:0061180 | mammary gland epithelium development | 21 | 52 | 1.66e-02 |
| GO:BP | GO:0048645 | animal organ formation | 21 | 52 | 1.66e-02 |
| GO:BP | GO:0007265 | Ras protein signal transduction | 33 | 95 | 1.67e-02 |
| GO:BP | GO:0035270 | endocrine system development | 30 | 84 | 1.68e-02 |
| GO:BP | GO:0072089 | stem cell proliferation | 30 | 84 | 1.68e-02 |
| GO:BP | GO:0060606 | tube closure | 30 | 84 | 1.68e-02 |
| GO:BP | GO:0051250 | negative regulation of lymphocyte activation | 30 | 84 | 1.68e-02 |
| GO:BP | GO:0016525 | negative regulation of angiogenesis | 25 | 66 | 1.68e-02 |
| GO:BP | GO:0032943 | mononuclear cell proliferation | 49 | 157 | 1.80e-02 |
| GO:BP | GO:0051641 | cellular localization | 593 | 2623 | 1.80e-02 |
| GO:BP | GO:0010001 | glial cell differentiation | 55 | 181 | 1.83e-02 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | 84 | 300 | 1.83e-02 |
| GO:BP | GO:0007162 | negative regulation of cell adhesion | 56 | 185 | 1.83e-02 |
| GO:BP | GO:0051251 | positive regulation of lymphocyte activation | 56 | 185 | 1.83e-02 |
| GO:BP | GO:0040008 | regulation of growth | 122 | 462 | 1.83e-02 |
| GO:BP | GO:0006810 | transport | 669 | 2984 | 1.84e-02 |
| GO:BP | GO:0099565 | chemical synaptic transmission, postsynaptic | 26 | 70 | 1.84e-02 |
| GO:BP | GO:0002376 | immune system process | 333 | 1410 | 1.84e-02 |
| GO:BP | GO:0003417 | growth plate cartilage development | 9 | 15 | 1.86e-02 |
| GO:BP | GO:0001780 | neutrophil homeostasis | 9 | 15 | 1.86e-02 |
| GO:BP | GO:0003229 | ventricular cardiac muscle tissue development | 22 | 56 | 1.86e-02 |
| GO:BP | GO:0002694 | regulation of leukocyte activation | 87 | 313 | 1.86e-02 |
| GO:BP | GO:0070663 | regulation of leukocyte proliferation | 42 | 130 | 1.86e-02 |
| GO:BP | GO:0001841 | neural tube formation | 32 | 92 | 1.86e-02 |
| GO:BP | GO:0010927 | cellular component assembly involved in morphogenesis | 36 | 107 | 1.86e-02 |
| GO:BP | GO:0051282 | regulation of sequestering of calcium ion | 32 | 92 | 1.86e-02 |
| GO:BP | GO:0072170 | metanephric tubule development | 9 | 15 | 1.86e-02 |
| GO:BP | GO:0086001 | cardiac muscle cell action potential | 24 | 63 | 1.86e-02 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | 601 | 2663 | 1.88e-02 |
| GO:BP | GO:0098662 | inorganic cation transmembrane transport | 126 | 480 | 1.88e-02 |
| GO:BP | GO:0031641 | regulation of myelination | 16 | 36 | 1.92e-02 |
| GO:BP | GO:0030336 | negative regulation of cell migration | 62 | 210 | 1.95e-02 |
| GO:BP | GO:0006874 | intracellular calcium ion homeostasis | 60 | 202 | 1.98e-02 |
| GO:BP | GO:0010717 | regulation of epithelial to mesenchymal transition | 30 | 85 | 1.98e-02 |
| GO:BP | GO:0071872 | cellular response to epinephrine stimulus | 7 | 10 | 1.98e-02 |
| GO:BP | GO:0010810 | regulation of cell-substrate adhesion | 50 | 162 | 2.00e-02 |
| GO:BP | GO:0001649 | osteoblast differentiation | 53 | 174 | 2.01e-02 |
| GO:BP | GO:0010799 | regulation of peptidyl-threonine phosphorylation | 15 | 33 | 2.05e-02 |
| GO:BP | GO:0098771 | inorganic ion homeostasis | 95 | 348 | 2.05e-02 |
| GO:BP | GO:0030902 | hindbrain development | 35 | 104 | 2.08e-02 |
| GO:BP | GO:0051209 | release of sequestered calcium ion into cytosol | 31 | 89 | 2.08e-02 |
| GO:BP | GO:0030282 | bone mineralization | 28 | 78 | 2.10e-02 |
| GO:BP | GO:0060444 | branching involved in mammary gland duct morphogenesis | 10 | 18 | 2.11e-02 |
| GO:BP | GO:0031646 | positive regulation of nervous system process | 10 | 18 | 2.11e-02 |
| GO:BP | GO:0050870 | positive regulation of T cell activation | 43 | 135 | 2.15e-02 |
| GO:BP | GO:0034220 | monoatomic ion transmembrane transport | 150 | 587 | 2.16e-02 |
| GO:BP | GO:0071526 | semaphorin-plexin signaling pathway | 18 | 43 | 2.16e-02 |
| GO:BP | GO:0045598 | regulation of fat cell differentiation | 32 | 93 | 2.17e-02 |
| GO:BP | GO:0043370 | regulation of CD4-positive, alpha-beta T cell differentiation | 13 | 27 | 2.22e-02 |
| GO:BP | GO:0031279 | regulation of cyclase activity | 13 | 27 | 2.22e-02 |
| GO:BP | GO:0098901 | regulation of cardiac muscle cell action potential | 13 | 27 | 2.22e-02 |
| GO:BP | GO:0021591 | ventricular system development | 13 | 27 | 2.22e-02 |
| GO:BP | GO:0007163 | establishment or maintenance of cell polarity | 55 | 183 | 2.24e-02 |
| GO:BP | GO:0001818 | negative regulation of cytokine production | 50 | 163 | 2.24e-02 |
| GO:BP | GO:0070372 | regulation of ERK1 and ERK2 cascade | 53 | 175 | 2.24e-02 |
| GO:BP | GO:0010882 | regulation of cardiac muscle contraction by calcium ion signaling | 12 | 24 | 2.25e-02 |
| GO:BP | GO:0050868 | negative regulation of T cell activation | 24 | 64 | 2.26e-02 |
| GO:BP | GO:0090497 | mesenchymal cell migration | 20 | 50 | 2.26e-02 |
| GO:BP | GO:1901019 | regulation of calcium ion transmembrane transporter activity | 20 | 50 | 2.26e-02 |
| GO:BP | GO:0043954 | cellular component maintenance | 22 | 57 | 2.29e-02 |
| GO:BP | GO:0006793 | phosphorus metabolic process | 438 | 1904 | 2.35e-02 |
| GO:BP | GO:0048871 | multicellular organismal-level homeostasis | 138 | 536 | 2.39e-02 |
| GO:BP | GO:0050801 | monoatomic ion homeostasis | 108 | 406 | 2.46e-02 |
| GO:BP | GO:0055002 | striated muscle cell development | 25 | 68 | 2.47e-02 |
| GO:BP | GO:0001822 | kidney development | 68 | 237 | 2.47e-02 |
| GO:BP | GO:0031099 | regeneration | 45 | 144 | 2.49e-02 |
| GO:BP | GO:1904062 | regulation of monoatomic cation transmembrane transport | 56 | 188 | 2.49e-02 |
| GO:BP | GO:0031032 | actomyosin structure organization | 55 | 184 | 2.49e-02 |
| GO:BP | GO:0002761 | regulation of myeloid leukocyte differentiation | 28 | 79 | 2.49e-02 |
| GO:BP | GO:0045927 | positive regulation of growth | 55 | 184 | 2.49e-02 |
| GO:BP | GO:0007411 | axon guidance | 52 | 172 | 2.49e-02 |
| GO:BP | GO:0009612 | response to mechanical stimulus | 47 | 152 | 2.49e-02 |
| GO:BP | GO:0003002 | regionalization | 73 | 258 | 2.49e-02 |
| GO:BP | GO:0097485 | neuron projection guidance | 52 | 172 | 2.49e-02 |
| GO:BP | GO:0098742 | cell-cell adhesion via plasma-membrane adhesion molecules | 47 | 152 | 2.49e-02 |
| GO:BP | GO:0002067 | glandular epithelial cell differentiation | 19 | 47 | 2.49e-02 |
| GO:BP | GO:0003176 | aortic valve development | 16 | 37 | 2.52e-02 |
| GO:BP | GO:1900116 | extracellular negative regulation of signal transduction | 6 | 8 | 2.52e-02 |
| GO:BP | GO:0106120 | positive regulation of sterol biosynthetic process | 6 | 8 | 2.52e-02 |
| GO:BP | GO:0045542 | positive regulation of cholesterol biosynthetic process | 6 | 8 | 2.52e-02 |
| GO:BP | GO:0032634 | interleukin-5 production | 6 | 8 | 2.52e-02 |
| GO:BP | GO:0032674 | regulation of interleukin-5 production | 6 | 8 | 2.52e-02 |
| GO:BP | GO:0003418 | growth plate cartilage chondrocyte differentiation | 6 | 8 | 2.52e-02 |
| GO:BP | GO:1900115 | extracellular regulation of signal transduction | 6 | 8 | 2.52e-02 |
| GO:BP | GO:0043085 | positive regulation of catalytic activity | 140 | 546 | 2.52e-02 |
| GO:BP | GO:2000146 | negative regulation of cell motility | 63 | 217 | 2.55e-02 |
| GO:BP | GO:0001843 | neural tube closure | 29 | 83 | 2.58e-02 |
| GO:BP | GO:0009952 | anterior/posterior pattern specification | 39 | 121 | 2.58e-02 |
| GO:BP | GO:1905874 | regulation of postsynaptic density organization | 8 | 13 | 2.58e-02 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | 26 | 72 | 2.58e-02 |
| GO:BP | GO:0002696 | positive regulation of leukocyte activation | 58 | 197 | 2.68e-02 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | 196 | 796 | 2.68e-02 |
| GO:BP | GO:0003230 | cardiac atrium development | 15 | 34 | 2.68e-02 |
| GO:BP | GO:0003161 | cardiac conduction system development | 15 | 34 | 2.68e-02 |
| GO:BP | GO:0032330 | regulation of chondrocyte differentiation | 15 | 34 | 2.68e-02 |
| GO:BP | GO:0001837 | epithelial to mesenchymal transition | 43 | 137 | 2.68e-02 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | 351 | 1504 | 2.68e-02 |
| GO:BP | GO:0010586 | miRNA metabolic process | 30 | 87 | 2.68e-02 |
| GO:BP | GO:0003170 | heart valve development | 24 | 65 | 2.68e-02 |
| GO:BP | GO:0034103 | regulation of tissue remodeling | 18 | 44 | 2.68e-02 |
| GO:BP | GO:0051216 | cartilage development | 45 | 145 | 2.72e-02 |
| GO:BP | GO:0060996 | dendritic spine development | 27 | 76 | 2.72e-02 |
| GO:BP | GO:0060395 | SMAD protein signal transduction | 27 | 76 | 2.72e-02 |
| GO:BP | GO:0048844 | artery morphogenesis | 22 | 58 | 2.75e-02 |
| GO:BP | GO:0019935 | cyclic-nucleotide-mediated signaling | 20 | 51 | 2.76e-02 |
| GO:BP | GO:0006812 | monoatomic cation transport | 155 | 614 | 2.78e-02 |
| GO:BP | GO:0045687 | positive regulation of glial cell differentiation | 14 | 31 | 2.85e-02 |
| GO:BP | GO:0034765 | regulation of monoatomic ion transmembrane transport | 61 | 210 | 2.85e-02 |
| GO:BP | GO:0140747 | regulation of ncRNA transcription | 28 | 80 | 2.88e-02 |
| GO:BP | GO:0001503 | ossification | 83 | 302 | 2.92e-02 |
| GO:BP | GO:0010468 | regulation of gene expression | 748 | 3379 | 2.92e-02 |
| GO:BP | GO:0001934 | positive regulation of protein phosphorylation | 105 | 396 | 2.92e-02 |
| GO:BP | GO:0097553 | calcium ion transmembrane import into cytosol | 39 | 122 | 2.92e-02 |
| GO:BP | GO:1905314 | semi-lunar valve development | 17 | 41 | 2.93e-02 |
| GO:BP | GO:0098815 | modulation of excitatory postsynaptic potential | 17 | 41 | 2.93e-02 |
| GO:BP | GO:0072273 | metanephric nephron morphogenesis | 9 | 16 | 2.93e-02 |
| GO:BP | GO:0010893 | positive regulation of steroid biosynthetic process | 9 | 16 | 2.93e-02 |
| GO:BP | GO:0032814 | regulation of natural killer cell activation | 9 | 16 | 2.93e-02 |
| GO:BP | GO:0048339 | paraxial mesoderm development | 9 | 16 | 2.93e-02 |
| GO:BP | GO:0072207 | metanephric epithelium development | 9 | 16 | 2.93e-02 |
| GO:BP | GO:2000463 | positive regulation of excitatory postsynaptic potential | 13 | 28 | 2.94e-02 |
| GO:BP | GO:0032898 | neurotrophin production | 4 | 4 | 2.94e-02 |
| GO:BP | GO:0098910 | regulation of atrial cardiac muscle cell action potential | 4 | 4 | 2.94e-02 |
| GO:BP | GO:0003171 | atrioventricular valve development | 13 | 28 | 2.94e-02 |
| GO:BP | GO:0003208 | cardiac ventricle morphogenesis | 23 | 62 | 2.94e-02 |
| GO:BP | GO:0014808 | release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 13 | 28 | 2.94e-02 |
| GO:BP | GO:1903514 | release of sequestered calcium ion into cytosol by endoplasmic reticulum | 13 | 28 | 2.94e-02 |
| GO:BP | GO:0001659 | temperature homeostasis | 41 | 130 | 2.94e-02 |
| GO:BP | GO:0110030 | regulation of G2/MI transition of meiotic cell cycle | 4 | 4 | 2.94e-02 |
| GO:BP | GO:0050790 | regulation of catalytic activity | 217 | 893 | 2.94e-02 |
| GO:BP | GO:1904045 | cellular response to aldosterone | 4 | 4 | 2.94e-02 |
| GO:BP | GO:0061026 | cardiac muscle tissue regeneration | 5 | 6 | 2.94e-02 |
| GO:BP | GO:2000051 | negative regulation of non-canonical Wnt signaling pathway | 5 | 6 | 2.94e-02 |
| GO:BP | GO:1903243 | negative regulation of cardiac muscle hypertrophy in response to stress | 5 | 6 | 2.94e-02 |
| GO:BP | GO:0010616 | negative regulation of cardiac muscle adaptation | 5 | 6 | 2.94e-02 |
| GO:BP | GO:0030432 | peristalsis | 5 | 6 | 2.94e-02 |
| GO:BP | GO:0006166 | purine ribonucleoside salvage | 5 | 6 | 2.94e-02 |
| GO:BP | GO:0072173 | metanephric tubule morphogenesis | 5 | 6 | 2.94e-02 |
| GO:BP | GO:0050768 | negative regulation of neurogenesis | 34 | 103 | 2.95e-02 |
| GO:BP | GO:0055080 | monoatomic cation homeostasis | 106 | 401 | 2.95e-02 |
| GO:BP | GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 45 | 146 | 2.96e-02 |
| GO:BP | GO:0048145 | regulation of fibroblast proliferation | 26 | 73 | 2.96e-02 |
| GO:BP | GO:0001755 | neural crest cell migration | 19 | 48 | 2.96e-02 |
| GO:BP | GO:0051145 | smooth muscle cell differentiation | 21 | 55 | 2.96e-02 |
| GO:BP | GO:2000629 | negative regulation of miRNA metabolic process | 12 | 25 | 3.00e-02 |
| GO:BP | GO:0003184 | pulmonary valve morphogenesis | 10 | 19 | 3.01e-02 |
| GO:BP | GO:0019934 | cGMP-mediated signaling | 10 | 19 | 3.01e-02 |
| GO:BP | GO:0099637 | neurotransmitter receptor transport | 10 | 19 | 3.01e-02 |
| GO:BP | GO:0099558 | maintenance of synapse structure | 11 | 22 | 3.03e-02 |
| GO:BP | GO:0048499 | synaptic vesicle membrane organization | 11 | 22 | 3.03e-02 |
| GO:BP | GO:0002021 | response to dietary excess | 11 | 22 | 3.03e-02 |
| GO:BP | GO:0009119 | ribonucleoside metabolic process | 11 | 22 | 3.03e-02 |
| GO:BP | GO:0031326 | regulation of cellular biosynthetic process | 787 | 3569 | 3.03e-02 |
| GO:BP | GO:0050867 | positive regulation of cell activation | 59 | 203 | 3.07e-02 |
| GO:BP | GO:0045668 | negative regulation of osteoblast differentiation | 16 | 38 | 3.08e-02 |
| GO:BP | GO:1902106 | negative regulation of leukocyte differentiation | 24 | 66 | 3.10e-02 |
| GO:BP | GO:0072006 | nephron development | 37 | 115 | 3.10e-02 |
| GO:BP | GO:0051234 | establishment of localization | 718 | 3240 | 3.11e-02 |
| GO:BP | GO:0007272 | ensheathment of neurons | 38 | 119 | 3.14e-02 |
| GO:BP | GO:0008366 | axon ensheathment | 38 | 119 | 3.14e-02 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | 207 | 850 | 3.15e-02 |
| GO:BP | GO:0051208 | sequestering of calcium ion | 32 | 96 | 3.19e-02 |
| GO:BP | GO:0048732 | gland development | 84 | 308 | 3.19e-02 |
| GO:BP | GO:0003006 | developmental process involved in reproduction | 145 | 573 | 3.19e-02 |
| GO:BP | GO:0007548 | sex differentiation | 53 | 179 | 3.21e-02 |
| GO:BP | GO:2000027 | regulation of animal organ morphogenesis | 22 | 59 | 3.21e-02 |
| GO:BP | GO:0070661 | leukocyte proliferation | 52 | 175 | 3.22e-02 |
| GO:BP | GO:1903312 | negative regulation of mRNA metabolic process | 28 | 81 | 3.22e-02 |
| GO:BP | GO:0051017 | actin filament bundle assembly | 41 | 131 | 3.22e-02 |
| GO:BP | GO:0045637 | regulation of myeloid cell differentiation | 42 | 135 | 3.24e-02 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | 769 | 3486 | 3.26e-02 |
| GO:BP | GO:0098659 | inorganic cation import across plasma membrane | 25 | 70 | 3.26e-02 |
| GO:BP | GO:0099587 | inorganic ion import across plasma membrane | 25 | 70 | 3.26e-02 |
| GO:BP | GO:0046651 | lymphocyte proliferation | 46 | 151 | 3.26e-02 |
| GO:BP | GO:0044089 | positive regulation of cellular component biogenesis | 103 | 390 | 3.31e-02 |
| GO:BP | GO:0006873 | intracellular monoatomic ion homeostasis | 96 | 360 | 3.35e-02 |
| GO:BP | GO:0060840 | artery development | 29 | 85 | 3.35e-02 |
| GO:BP | GO:0032101 | regulation of response to external stimulus | 163 | 654 | 3.36e-02 |
| GO:BP | GO:1903169 | regulation of calcium ion transmembrane transport | 35 | 108 | 3.41e-02 |
| GO:BP | GO:0021670 | lateral ventricle development | 7 | 11 | 3.41e-02 |
| GO:BP | GO:0072077 | renal vesicle morphogenesis | 7 | 11 | 3.41e-02 |
| GO:BP | GO:0035435 | phosphate ion transmembrane transport | 7 | 11 | 3.41e-02 |
| GO:BP | GO:0098655 | monoatomic cation transmembrane transport | 127 | 495 | 3.41e-02 |
| GO:BP | GO:0021783 | preganglionic parasympathetic fiber development | 7 | 11 | 3.41e-02 |
| GO:BP | GO:0030852 | regulation of granulocyte differentiation | 7 | 11 | 3.41e-02 |
| GO:BP | GO:1904044 | response to aldosterone | 7 | 11 | 3.41e-02 |
| GO:BP | GO:0060033 | anatomical structure regression | 7 | 11 | 3.41e-02 |
| GO:BP | GO:0032411 | positive regulation of transporter activity | 23 | 63 | 3.41e-02 |
| GO:BP | GO:0009611 | response to wounding | 101 | 382 | 3.43e-02 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | 545 | 2422 | 3.43e-02 |
| GO:BP | GO:0043500 | muscle adaptation | 30 | 89 | 3.43e-02 |
| GO:BP | GO:0014070 | response to organic cyclic compound | 152 | 606 | 3.51e-02 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | 791 | 3595 | 3.51e-02 |
| GO:BP | GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | 78 | 284 | 3.51e-02 |
| GO:BP | GO:0010656 | negative regulation of muscle cell apoptotic process | 14 | 32 | 3.56e-02 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | 923 | 4231 | 3.57e-02 |
| GO:BP | GO:0060078 | regulation of postsynaptic membrane potential | 27 | 78 | 3.58e-02 |
| GO:BP | GO:0045685 | regulation of glial cell differentiation | 19 | 49 | 3.58e-02 |
| GO:BP | GO:1901698 | response to nitrogen compound | 181 | 736 | 3.58e-02 |
| GO:BP | GO:0061572 | actin filament bundle organization | 41 | 132 | 3.59e-02 |
| GO:BP | GO:0032409 | regulation of transporter activity | 45 | 148 | 3.62e-02 |
| GO:BP | GO:0002695 | negative regulation of leukocyte activation | 32 | 97 | 3.63e-02 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | 542 | 2410 | 3.64e-02 |
| GO:BP | GO:0071407 | cellular response to organic cyclic compound | 100 | 379 | 3.76e-02 |
| GO:BP | GO:0060041 | retina development in camera-type eye | 34 | 105 | 3.81e-02 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | 22 | 60 | 3.85e-02 |
| GO:BP | GO:0051961 | negative regulation of nervous system development | 35 | 109 | 3.88e-02 |
| GO:BP | GO:0042129 | regulation of T cell proliferation | 29 | 86 | 3.90e-02 |
| GO:BP | GO:0014009 | glial cell proliferation | 16 | 39 | 3.90e-02 |
| GO:BP | GO:0046578 | regulation of Ras protein signal transduction | 16 | 39 | 3.90e-02 |
| GO:BP | GO:0022408 | negative regulation of cell-cell adhesion | 36 | 113 | 3.93e-02 |
| GO:BP | GO:0051172 | negative regulation of nitrogen compound metabolic process | 376 | 1633 | 3.95e-02 |
| GO:BP | GO:2000106 | regulation of leukocyte apoptotic process | 20 | 53 | 3.97e-02 |
| GO:BP | GO:0042552 | myelination | 37 | 117 | 3.97e-02 |
| GO:BP | GO:0046847 | filopodium assembly | 20 | 53 | 3.97e-02 |
| GO:BP | GO:0003197 | endocardial cushion development | 18 | 46 | 3.97e-02 |
| GO:BP | GO:1903540 | establishment of protein localization to postsynaptic membrane | 8 | 14 | 3.97e-02 |
| GO:BP | GO:0016202 | regulation of striated muscle tissue development | 8 | 14 | 3.97e-02 |
| GO:BP | GO:1990845 | adaptive thermogenesis | 38 | 121 | 3.97e-02 |
| GO:BP | GO:0048485 | sympathetic nervous system development | 8 | 14 | 3.97e-02 |
| GO:BP | GO:0010885 | regulation of cholesterol storage | 8 | 14 | 3.97e-02 |
| GO:BP | GO:0043217 | myelin maintenance | 8 | 14 | 3.97e-02 |
| GO:BP | GO:0098969 | neurotransmitter receptor transport to postsynaptic membrane | 8 | 14 | 3.97e-02 |
| GO:BP | GO:0072234 | metanephric nephron tubule development | 8 | 14 | 3.97e-02 |
| GO:BP | GO:0098657 | import into cell | 155 | 622 | 4.00e-02 |
| GO:BP | GO:0010976 | positive regulation of neuron projection development | 40 | 129 | 4.01e-02 |
| GO:BP | GO:0045937 | positive regulation of phosphate metabolic process | 119 | 463 | 4.04e-02 |
| GO:BP | GO:0010562 | positive regulation of phosphorus metabolic process | 119 | 463 | 4.04e-02 |
| GO:BP | GO:0042327 | positive regulation of phosphorylation | 108 | 415 | 4.05e-02 |
| GO:BP | GO:0070371 | ERK1 and ERK2 cascade | 56 | 194 | 4.13e-02 |
| GO:BP | GO:0043269 | regulation of monoatomic ion transport | 77 | 282 | 4.13e-02 |
| GO:BP | GO:0044342 | type B pancreatic cell proliferation | 11 | 23 | 4.13e-02 |
| GO:BP | GO:0003283 | atrial septum development | 11 | 23 | 4.13e-02 |
| GO:BP | GO:0071345 | cellular response to cytokine stimulus | 133 | 525 | 4.13e-02 |
| GO:BP | GO:0061036 | positive regulation of cartilage development | 11 | 23 | 4.13e-02 |
| GO:BP | GO:0010664 | negative regulation of striated muscle cell apoptotic process | 11 | 23 | 4.13e-02 |
| GO:BP | GO:0030278 | regulation of ossification | 27 | 79 | 4.13e-02 |
| GO:BP | GO:0098698 | postsynaptic specialization assembly | 11 | 23 | 4.13e-02 |
| GO:BP | GO:0051491 | positive regulation of filopodium assembly | 11 | 23 | 4.13e-02 |
| GO:BP | GO:1902894 | negative regulation of miRNA transcription | 11 | 23 | 4.13e-02 |
| GO:BP | GO:0045761 | regulation of adenylate cyclase activity | 11 | 23 | 4.13e-02 |
| GO:BP | GO:0048668 | collateral sprouting | 11 | 23 | 4.13e-02 |
| GO:BP | GO:0045667 | regulation of osteoblast differentiation | 32 | 98 | 4.13e-02 |
| GO:BP | GO:0003416 | endochondral bone growth | 11 | 23 | 4.13e-02 |
| GO:BP | GO:0003215 | cardiac right ventricle morphogenesis | 9 | 17 | 4.15e-02 |
| GO:BP | GO:0060392 | negative regulation of SMAD protein signal transduction | 9 | 17 | 4.15e-02 |
| GO:BP | GO:0097107 | postsynaptic density assembly | 9 | 17 | 4.15e-02 |
| GO:BP | GO:0003203 | endocardial cushion morphogenesis | 15 | 36 | 4.15e-02 |
| GO:BP | GO:0032528 | microvillus organization | 9 | 17 | 4.15e-02 |
| GO:BP | GO:0030003 | intracellular monoatomic cation homeostasis | 94 | 355 | 4.15e-02 |
| GO:BP | GO:0048670 | regulation of collateral sprouting | 9 | 17 | 4.15e-02 |
| GO:BP | GO:0060575 | intestinal epithelial cell differentiation | 9 | 17 | 4.15e-02 |
| GO:BP | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | 10 | 20 | 4.16e-02 |
| GO:BP | GO:0035024 | negative regulation of Rho protein signal transduction | 10 | 20 | 4.16e-02 |
| GO:BP | GO:0043502 | regulation of muscle adaptation | 24 | 68 | 4.16e-02 |
| GO:BP | GO:0055082 | intracellular chemical homeostasis | 124 | 486 | 4.16e-02 |
| GO:BP | GO:0099560 | synaptic membrane adhesion | 10 | 20 | 4.16e-02 |
| GO:BP | GO:0032946 | positive regulation of mononuclear cell proliferation | 24 | 68 | 4.16e-02 |
| GO:BP | GO:0007043 | cell-cell junction assembly | 34 | 106 | 4.16e-02 |
| GO:BP | GO:0002286 | T cell activation involved in immune response | 21 | 57 | 4.16e-02 |
| GO:BP | GO:0001819 | positive regulation of cytokine production | 71 | 257 | 4.16e-02 |
| GO:BP | GO:0014074 | response to purine-containing compound | 34 | 106 | 4.16e-02 |
| GO:BP | GO:1902373 | negative regulation of mRNA catabolic process | 21 | 57 | 4.16e-02 |
| GO:BP | GO:0060993 | kidney morphogenesis | 24 | 68 | 4.16e-02 |
| GO:BP | GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 28 | 83 | 4.18e-02 |
| GO:BP | GO:0045834 | positive regulation of lipid metabolic process | 28 | 83 | 4.18e-02 |
| GO:BP | GO:0042490 | mechanoreceptor differentiation | 19 | 50 | 4.23e-02 |
| GO:BP | GO:0042981 | regulation of apoptotic process | 245 | 1031 | 4.23e-02 |
| GO:BP | GO:0010660 | regulation of muscle cell apoptotic process | 19 | 50 | 4.23e-02 |
| GO:BP | GO:0031016 | pancreas development | 19 | 50 | 4.23e-02 |
| GO:BP | GO:0009880 | embryonic pattern specification | 17 | 43 | 4.24e-02 |
| GO:BP | GO:0046660 | female sex differentiation | 29 | 87 | 4.29e-02 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | 159 | 642 | 4.29e-02 |
| GO:BP | GO:0030326 | embryonic limb morphogenesis | 29 | 87 | 4.29e-02 |
| GO:BP | GO:0035113 | embryonic appendage morphogenesis | 29 | 87 | 4.29e-02 |
| GO:BP | GO:0048593 | camera-type eye morphogenesis | 29 | 87 | 4.29e-02 |
| GO:BP | GO:0051050 | positive regulation of transport | 143 | 571 | 4.38e-02 |
| GO:BP | GO:0061614 | miRNA transcription | 22 | 61 | 4.40e-02 |
| GO:BP | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules | 30 | 91 | 4.41e-02 |
| GO:BP | GO:0055074 | calcium ion homeostasis | 61 | 216 | 4.48e-02 |
| GO:BP | GO:0140352 | export from cell | 148 | 594 | 4.53e-02 |
| GO:BP | GO:0003162 | atrioventricular node development | 6 | 9 | 4.53e-02 |
| GO:BP | GO:0072189 | ureter development | 6 | 9 | 4.53e-02 |
| GO:BP | GO:0014745 | negative regulation of muscle adaptation | 6 | 9 | 4.53e-02 |
| GO:BP | GO:0086027 | AV node cell to bundle of His cell signaling | 6 | 9 | 4.53e-02 |
| GO:BP | GO:0048671 | negative regulation of collateral sprouting | 6 | 9 | 4.53e-02 |
| GO:BP | GO:0042693 | muscle cell fate commitment | 6 | 9 | 4.53e-02 |
| GO:BP | GO:0048340 | paraxial mesoderm morphogenesis | 6 | 9 | 4.53e-02 |
| GO:BP | GO:0086016 | AV node cell action potential | 6 | 9 | 4.53e-02 |
| GO:BP | GO:0046854 | phosphatidylinositol phosphate biosynthetic process | 20 | 54 | 4.60e-02 |
| GO:BP | GO:0060079 | excitatory postsynaptic potential | 23 | 65 | 4.67e-02 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 349 | 1514 | 4.70e-02 |
| GO:BP | GO:0045600 | positive regulation of fat cell differentiation | 18 | 47 | 4.72e-02 |
| GO:BP | GO:0014015 | positive regulation of gliogenesis | 18 | 47 | 4.72e-02 |
| GO:BP | GO:0060491 | regulation of cell projection assembly | 47 | 159 | 4.77e-02 |
| GO:BP | GO:0060070 | canonical Wnt signaling pathway | 67 | 242 | 4.83e-02 |
| GO:BP | GO:0099068 | postsynapse assembly | 13 | 30 | 4.84e-02 |
| GO:BP | GO:0046850 | regulation of bone remodeling | 13 | 30 | 4.84e-02 |
| GO:BP | GO:0061351 | neural precursor cell proliferation | 37 | 119 | 4.85e-02 |
| GO:BP | GO:0141091 | transforming growth factor beta receptor superfamily signaling pathway | 71 | 259 | 4.86e-02 |
| GO:BP | GO:0022898 | regulation of transmembrane transporter activity | 42 | 139 | 4.88e-02 |
| GO:BP | GO:0060021 | roof of mouth development | 24 | 69 | 4.89e-02 |
| GO:BP | GO:0006939 | smooth muscle contraction | 24 | 69 | 4.89e-02 |
| GO:BP | GO:0010243 | response to organonitrogen compound | 168 | 685 | 4.89e-02 |
| GO:BP | GO:0032414 | positive regulation of ion transmembrane transporter activity | 21 | 58 | 4.93e-02 |
| GO:BP | GO:0072028 | nephron morphogenesis | 21 | 58 | 4.93e-02 |
| GO:BP | GO:0002062 | chondrocyte differentiation | 29 | 88 | 4.96e-02 |
ESR_int_restable %>%
filter(source=="KEGG") %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in ESR neargenes intersected with RNA response genes") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:04020 | Calcium signaling pathway | 51 | 161 | 5.13e-02 |
| KEGG | KEGG:04360 | Axon guidance | 50 | 155 | 5.13e-02 |
| KEGG | KEGG:04390 | Hippo signaling pathway | 43 | 129 | 5.13e-02 |
| KEGG | KEGG:04934 | Cushing syndrome | 39 | 119 | 7.61e-02 |
| KEGG | KEGG:04024 | cAMP signaling pathway | 46 | 147 | 7.61e-02 |
| KEGG | KEGG:04750 | Inflammatory mediator regulation of TRP channels | 26 | 72 | 7.98e-02 |
| KEGG | KEGG:04070 | Phosphatidylinositol signaling system | 28 | 83 | 1.16e-01 |
| KEGG | KEGG:04022 | cGMP-PKG signaling pathway | 40 | 129 | 1.16e-01 |
| KEGG | KEGG:04924 | Renin secretion | 19 | 50 | 1.16e-01 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | 25 | 77 | 1.28e-01 |
| KEGG | KEGG:04148 | Efferocytosis | 37 | 120 | 1.28e-01 |
| KEGG | KEGG:04911 | Insulin secretion | 22 | 62 | 1.28e-01 |
| KEGG | KEGG:00230 | Purine metabolism | 29 | 93 | 1.28e-01 |
| KEGG | KEGG:03250 | Viral life cycle - HIV-1 | 19 | 54 | 1.28e-01 |
| KEGG | KEGG:04740 | Olfactory transduction | 11 | 25 | 1.28e-01 |
| KEGG | KEGG:05226 | Gastric cancer | 34 | 113 | 1.28e-01 |
| KEGG | KEGG:05224 | Breast cancer | 35 | 113 | 1.28e-01 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | 33 | 105 | 1.28e-01 |
| KEGG | KEGG:04814 | Motor proteins | 41 | 141 | 1.28e-01 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | 47 | 162 | 1.28e-01 |
| KEGG | KEGG:04730 | Long-term depression | 15 | 39 | 1.28e-01 |
| KEGG | KEGG:04927 | Cortisol synthesis and secretion | 17 | 46 | 1.28e-01 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | 42 | 144 | 1.28e-01 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | 37 | 124 | 1.28e-01 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | 26 | 82 | 1.34e-01 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | 36 | 122 | 1.34e-01 |
| KEGG | KEGG:04260 | Cardiac muscle contraction | 21 | 63 | 1.36e-01 |
| KEGG | KEGG:04925 | Aldosterone synthesis and secretion | 24 | 75 | 1.36e-01 |
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | 22 | 67 | 1.36e-01 |
| KEGG | KEGG:04976 | Bile secretion | 15 | 41 | 1.36e-01 |
| KEGG | KEGG:04659 | Th17 cell differentiation | 20 | 60 | 1.41e-01 |
| KEGG | KEGG:04611 | Platelet activation | 27 | 88 | 1.46e-01 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | 23 | 72 | 1.46e-01 |
| KEGG | KEGG:04310 | Wnt signaling pathway | 38 | 133 | 1.46e-01 |
| KEGG | KEGG:04014 | Ras signaling pathway | 45 | 164 | 1.68e-01 |
| KEGG | KEGG:05032 | Morphine addiction | 18 | 54 | 1.68e-01 |
| KEGG | KEGG:04724 | Glutamatergic synapse | 23 | 74 | 1.78e-01 |
| KEGG | KEGG:03320 | PPAR signaling pathway | 16 | 47 | 1.80e-01 |
| KEGG | KEGG:03430 | Mismatch repair | 9 | 22 | 1.92e-01 |
| KEGG | KEGG:05164 | Influenza A | 28 | 95 | 1.92e-01 |
| KEGG | KEGG:04150 | mTOR signaling pathway | 36 | 129 | 1.98e-01 |
| KEGG | KEGG:05217 | Basal cell carcinoma | 16 | 48 | 1.98e-01 |
| KEGG | KEGG:00562 | Inositol phosphate metabolism | 19 | 60 | 1.98e-01 |
| KEGG | KEGG:05218 | Melanoma | 18 | 56 | 1.98e-01 |
| KEGG | KEGG:04913 | Ovarian steroidogenesis | 10 | 26 | 1.98e-01 |
| KEGG | KEGG:04950 | Maturity onset diabetes of the young | 3 | 4 | 2.08e-01 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | 29 | 101 | 2.08e-01 |
| KEGG | KEGG:04972 | Pancreatic secretion | 18 | 57 | 2.18e-01 |
| KEGG | KEGG:05034 | Alcoholism | 29 | 102 | 2.22e-01 |
| KEGG | KEGG:04658 | Th1 and Th2 cell differentiation | 16 | 50 | 2.37e-01 |
| KEGG | KEGG:04115 | p53 signaling pathway | 20 | 66 | 2.37e-01 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 23 | 78 | 2.37e-01 |
| KEGG | KEGG:04640 | Hematopoietic cell lineage | 10 | 28 | 2.52e-01 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | 31 | 113 | 2.52e-01 |
| KEGG | KEGG:04971 | Gastric acid secretion | 16 | 51 | 2.52e-01 |
| KEGG | KEGG:04960 | Aldosterone-regulated sodium reabsorption | 9 | 24 | 2.52e-01 |
| KEGG | KEGG:04380 | Osteoclast differentiation | 26 | 92 | 2.52e-01 |
| KEGG | KEGG:04540 | Gap junction | 21 | 71 | 2.52e-01 |
| KEGG | KEGG:04916 | Melanogenesis | 22 | 75 | 2.52e-01 |
| KEGG | KEGG:04713 | Circadian entrainment | 20 | 68 | 2.75e-01 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | 19 | 64 | 2.75e-01 |
| KEGG | KEGG:04330 | Notch signaling pathway | 16 | 52 | 2.76e-01 |
| KEGG | KEGG:04392 | Hippo signaling pathway - multiple species | 9 | 25 | 2.80e-01 |
| KEGG | KEGG:04721 | Synaptic vesicle cycle | 15 | 49 | 2.95e-01 |
| KEGG | KEGG:00910 | Nitrogen metabolism | 4 | 8 | 2.95e-01 |
| KEGG | KEGG:04725 | Cholinergic synapse | 23 | 82 | 2.95e-01 |
| KEGG | KEGG:04923 | Regulation of lipolysis in adipocytes | 13 | 41 | 2.95e-01 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | 36 | 137 | 2.95e-01 |
| KEGG | KEGG:05110 | Vibrio cholerae infection | 13 | 41 | 2.95e-01 |
| KEGG | KEGG:04929 | GnRH secretion | 15 | 50 | 3.02e-01 |
| KEGG | KEGG:04726 | Serotonergic synapse | 17 | 58 | 3.02e-01 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | 26 | 96 | 3.02e-01 |
| KEGG | KEGG:00000 | KEGG root term | 1145 | 5451 | 3.02e-01 |
| KEGG | KEGG:05213 | Endometrial cancer | 16 | 54 | 3.02e-01 |
| KEGG | KEGG:03083 | Polycomb repressive complex | 20 | 70 | 3.02e-01 |
| KEGG | KEGG:05200 | Pathways in cancer | 92 | 391 | 3.02e-01 |
| KEGG | KEGG:04970 | Salivary secretion | 16 | 54 | 3.02e-01 |
| KEGG | KEGG:04931 | Insulin resistance | 25 | 91 | 3.02e-01 |
| KEGG | KEGG:04061 | Viral protein interaction with cytokine and cytokine receptor | 7 | 19 | 3.05e-01 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 41 | 162 | 3.05e-01 |
| KEGG | KEGG:04270 | Vascular smooth muscle contraction | 25 | 92 | 3.05e-01 |
| KEGG | KEGG:00564 | Glycerophospholipid metabolism | 20 | 71 | 3.05e-01 |
| KEGG | KEGG:04720 | Long-term potentiation | 15 | 51 | 3.29e-01 |
| KEGG | KEGG:04613 | Neutrophil extracellular trap formation | 24 | 89 | 3.30e-01 |
| KEGG | KEGG:04930 | Type II diabetes mellitus | 11 | 35 | 3.33e-01 |
| KEGG | KEGG:04010 | MAPK signaling pathway | 56 | 231 | 3.33e-01 |
| KEGG | KEGG:04060 | Cytokine-cytokine receptor interaction | 25 | 94 | 3.42e-01 |
| KEGG | KEGG:04530 | Tight junction | 33 | 129 | 3.42e-01 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | 34 | 134 | 3.48e-01 |
| KEGG | KEGG:05221 | Acute myeloid leukemia | 15 | 52 | 3.48e-01 |
| KEGG | KEGG:04742 | Taste transduction | 7 | 20 | 3.48e-01 |
| KEGG | KEGG:04210 | Apoptosis | 29 | 112 | 3.48e-01 |
| KEGG | KEGG:04961 | Endocrine and other factor-regulated calcium reabsorption | 12 | 40 | 3.53e-01 |
| KEGG | KEGG:05214 | Glioma | 18 | 65 | 3.53e-01 |
| KEGG | KEGG:05030 | Cocaine addiction | 10 | 32 | 3.55e-01 |
| KEGG | KEGG:04910 | Insulin signaling pathway | 29 | 113 | 3.60e-01 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | 20 | 74 | 3.61e-01 |
| KEGG | KEGG:04650 | Natural killer cell mediated cytotoxicity | 15 | 53 | 3.68e-01 |
| KEGG | KEGG:05211 | Renal cell carcinoma | 17 | 62 | 3.85e-01 |
| KEGG | KEGG:04152 | AMPK signaling pathway | 26 | 101 | 3.85e-01 |
| KEGG | KEGG:04728 | Dopaminergic synapse | 25 | 97 | 3.92e-01 |
| KEGG | KEGG:05216 | Thyroid cancer | 10 | 33 | 3.92e-01 |
| KEGG | KEGG:04917 | Prolactin signaling pathway | 15 | 54 | 3.97e-01 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | 39 | 160 | 4.03e-01 |
| KEGG | KEGG:04072 | Phospholipase D signaling pathway | 27 | 107 | 4.21e-01 |
| KEGG | KEGG:05210 | Colorectal cancer | 21 | 81 | 4.27e-01 |
| KEGG | KEGG:04114 | Oocyte meiosis | 26 | 103 | 4.27e-01 |
| KEGG | KEGG:04071 | Sphingolipid signaling pathway | 26 | 103 | 4.27e-01 |
| KEGG | KEGG:04966 | Collecting duct acid secretion | 6 | 18 | 4.39e-01 |
| KEGG | KEGG:00410 | beta-Alanine metabolism | 7 | 22 | 4.39e-01 |
| KEGG | KEGG:04964 | Proximal tubule bicarbonate reclamation | 6 | 18 | 4.39e-01 |
| KEGG | KEGG:04370 | VEGF signaling pathway | 13 | 47 | 4.41e-01 |
| KEGG | KEGG:01522 | Endocrine resistance | 21 | 82 | 4.48e-01 |
| KEGG | KEGG:04974 | Protein digestion and absorption | 15 | 56 | 4.54e-01 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | 20 | 78 | 4.54e-01 |
| KEGG | KEGG:00591 | Linoleic acid metabolism | 3 | 7 | 4.54e-01 |
| KEGG | KEGG:04727 | GABAergic synapse | 14 | 52 | 4.56e-01 |
| KEGG | KEGG:05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 17 | 65 | 4.56e-01 |
| KEGG | KEGG:04520 | Adherens junction | 21 | 83 | 4.65e-01 |
| KEGG | KEGG:05165 | Human papillomavirus infection | 58 | 252 | 4.65e-01 |
| KEGG | KEGG:05160 | Hepatitis C | 27 | 110 | 4.65e-01 |
| KEGG | KEGG:03410 | Base excision repair | 12 | 44 | 4.74e-01 |
| KEGG | KEGG:04012 | ErbB signaling pathway | 19 | 75 | 4.85e-01 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | 34 | 143 | 4.85e-01 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | 34 | 143 | 4.85e-01 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | 29 | 120 | 4.85e-01 |
| KEGG | KEGG:05146 | Amoebiasis | 16 | 62 | 4.85e-01 |
| KEGG | KEGG:05212 | Pancreatic cancer | 18 | 71 | 4.88e-01 |
| KEGG | KEGG:00470 | D-Amino acid metabolism | 2 | 4 | 4.93e-01 |
| KEGG | KEGG:05031 | Amphetamine addiction | 12 | 45 | 5.01e-01 |
| KEGG | KEGG:05142 | Chagas disease | 18 | 72 | 5.07e-01 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | 22 | 90 | 5.07e-01 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | 22 | 90 | 5.07e-01 |
| KEGG | KEGG:05161 | Hepatitis B | 30 | 126 | 5.07e-01 |
| KEGG | KEGG:04217 | Necroptosis | 24 | 99 | 5.07e-01 |
| KEGG | KEGG:03260 | Virion - Human immunodeficiency virus | 1 | 1 | 5.09e-01 |
| KEGG | KEGG:04213 | Longevity regulating pathway - multiple species | 13 | 50 | 5.09e-01 |
| KEGG | KEGG:05321 | Inflammatory bowel disease | 6 | 20 | 5.14e-01 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | 38 | 164 | 5.16e-01 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | 20 | 82 | 5.19e-01 |
| KEGG | KEGG:03450 | Non-homologous end-joining | 4 | 12 | 5.19e-01 |
| KEGG | KEGG:05222 | Small cell lung cancer | 20 | 82 | 5.19e-01 |
| KEGG | KEGG:05120 | Epithelial cell signaling in Helicobacter pylori infection | 14 | 55 | 5.19e-01 |
| KEGG | KEGG:04973 | Carbohydrate digestion and absorption | 8 | 29 | 5.29e-01 |
| KEGG | KEGG:04136 | Autophagy - other | 8 | 29 | 5.29e-01 |
| KEGG | KEGG:05152 | Tuberculosis | 24 | 101 | 5.39e-01 |
| KEGG | KEGG:04978 | Mineral absorption | 10 | 38 | 5.41e-01 |
| KEGG | KEGG:04912 | GnRH signaling pathway | 18 | 74 | 5.46e-01 |
| KEGG | KEGG:03030 | DNA replication | 9 | 34 | 5.58e-01 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | 20 | 84 | 5.72e-01 |
| KEGG | KEGG:04145 | Phagosome | 20 | 84 | 5.72e-01 |
| KEGG | KEGG:04140 | Autophagy - animal | 34 | 149 | 5.75e-01 |
| KEGG | KEGG:04977 | Vitamin digestion and absorption | 4 | 13 | 5.89e-01 |
| KEGG | KEGG:00750 | Vitamin B6 metabolism | 2 | 5 | 5.94e-01 |
| KEGG | KEGG:03265 | Virion - Ebolavirus and Lyssavirus | 2 | 5 | 5.94e-01 |
| KEGG | KEGG:00061 | Fatty acid biosynthesis | 3 | 9 | 5.94e-01 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | 30 | 132 | 6.09e-01 |
| KEGG | KEGG:00500 | Starch and sucrose metabolism | 6 | 22 | 6.09e-01 |
| KEGG | KEGG:04216 | Ferroptosis | 8 | 31 | 6.15e-01 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | 17 | 72 | 6.15e-01 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | 20 | 87 | 6.54e-01 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | 17 | 73 | 6.54e-01 |
| KEGG | KEGG:04068 | FoxO signaling pathway | 24 | 106 | 6.57e-01 |
| KEGG | KEGG:00601 | Glycosphingolipid biosynthesis - lacto and neolacto series | 4 | 14 | 6.57e-01 |
| KEGG | KEGG:04514 | Cell adhesion molecules | 16 | 69 | 6.57e-01 |
| KEGG | KEGG:04144 | Endocytosis | 47 | 216 | 6.57e-01 |
| KEGG | KEGG:04630 | JAK-STAT signaling pathway | 19 | 83 | 6.57e-01 |
| KEGG | KEGG:01524 | Platinum drug resistance | 14 | 60 | 6.57e-01 |
| KEGG | KEGG:05033 | Nicotine addiction | 3 | 10 | 6.57e-01 |
| KEGG | KEGG:04614 | Renin-angiotensin system | 3 | 10 | 6.57e-01 |
| KEGG | KEGG:00592 | alpha-Linolenic acid metabolism | 3 | 10 | 6.57e-01 |
| KEGG | KEGG:04668 | TNF signaling pathway | 19 | 83 | 6.57e-01 |
| KEGG | KEGG:04672 | Intestinal immune network for IgA production | 3 | 10 | 6.57e-01 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | 54 | 250 | 6.61e-01 |
| KEGG | KEGG:00515 | Mannose type O-glycan biosynthesis | 5 | 19 | 6.63e-01 |
| KEGG | KEGG:00534 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin | 5 | 19 | 6.63e-01 |
| KEGG | KEGG:04218 | Cellular senescence | 30 | 136 | 6.63e-01 |
| KEGG | KEGG:04211 | Longevity regulating pathway | 17 | 75 | 6.74e-01 |
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | 17 | 75 | 6.74e-01 |
| KEGG | KEGG:05203 | Viral carcinogenesis | 31 | 142 | 6.75e-01 |
| KEGG | KEGG:05330 | Allograft rejection | 1 | 2 | 6.75e-01 |
| KEGG | KEGG:05323 | Rheumatoid arthritis | 9 | 38 | 6.75e-01 |
| KEGG | KEGG:05332 | Graft-versus-host disease | 1 | 2 | 6.75e-01 |
| KEGG | KEGG:00770 | Pantothenate and CoA biosynthesis | 4 | 15 | 6.75e-01 |
| KEGG | KEGG:02010 | ABC transporters | 6 | 24 | 6.75e-01 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | 24 | 109 | 6.80e-01 |
| KEGG | KEGG:00532 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 5 | 20 | 7.05e-01 |
| KEGG | KEGG:04936 | Alcoholic liver disease | 20 | 91 | 7.11e-01 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | 13 | 58 | 7.19e-01 |
| KEGG | KEGG:04080 | Neuroactive ligand-receptor interaction | 22 | 101 | 7.19e-01 |
| KEGG | KEGG:05215 | Prostate cancer | 18 | 82 | 7.21e-01 |
| KEGG | KEGG:05322 | Systemic lupus erythematosus | 10 | 44 | 7.22e-01 |
| KEGG | KEGG:04920 | Adipocytokine signaling pathway | 11 | 49 | 7.31e-01 |
| KEGG | KEGG:05143 | African trypanosomiasis | 4 | 16 | 7.33e-01 |
| KEGG | KEGG:00514 | Other types of O-glycan biosynthesis | 8 | 35 | 7.35e-01 |
| KEGG | KEGG:03420 | Nucleotide excision repair | 12 | 54 | 7.35e-01 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | 29 | 136 | 7.35e-01 |
| KEGG | KEGG:00052 | Galactose metabolism | 5 | 21 | 7.42e-01 |
| KEGG | KEGG:04940 | Type I diabetes mellitus | 2 | 7 | 7.43e-01 |
| KEGG | KEGG:04744 | Phototransduction | 3 | 12 | 7.76e-01 |
| KEGG | KEGG:04064 | NF-kappa B signaling pathway | 13 | 61 | 8.11e-01 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | 16 | 76 | 8.11e-01 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | 31 | 149 | 8.11e-01 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | 18 | 86 | 8.11e-01 |
| KEGG | KEGG:05320 | Autoimmune thyroid disease | 1 | 3 | 8.11e-01 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | 11 | 52 | 8.11e-01 |
| KEGG | KEGG:00600 | Sphingolipid metabolism | 9 | 42 | 8.11e-01 |
| KEGG | KEGG:05131 | Shigellosis | 42 | 204 | 8.11e-01 |
| KEGG | KEGG:00290 | Valine, leucine and isoleucine biosynthesis | 1 | 3 | 8.11e-01 |
| KEGG | KEGG:00270 | Cysteine and methionine metabolism | 8 | 37 | 8.11e-01 |
| KEGG | KEGG:05340 | Primary immunodeficiency | 2 | 8 | 8.20e-01 |
| KEGG | KEGG:01040 | Biosynthesis of unsaturated fatty acids | 5 | 23 | 8.31e-01 |
| KEGG | KEGG:05135 | Yersinia infection | 22 | 107 | 8.31e-01 |
| KEGG | KEGG:05140 | Leishmaniasis | 8 | 38 | 8.33e-01 |
| KEGG | KEGG:04918 | Thyroid hormone synthesis | 11 | 53 | 8.36e-01 |
| KEGG | KEGG:00830 | Retinol metabolism | 3 | 14 | 8.93e-01 |
| KEGG | KEGG:04620 | Toll-like receptor signaling pathway | 12 | 60 | 9.11e-01 |
| KEGG | KEGG:00524 | Neomycin, kanamycin and gentamicin biosynthesis | 1 | 4 | 9.35e-01 |
| KEGG | KEGG:00220 | Arginine biosynthesis | 3 | 15 | 9.59e-01 |
| KEGG | KEGG:05416 | Viral myocarditis | 7 | 36 | 9.62e-01 |
| KEGG | KEGG:04130 | SNARE interactions in vesicular transport | 6 | 31 | 9.67e-01 |
| KEGG | KEGG:00051 | Fructose and mannose metabolism | 5 | 26 | 9.67e-01 |
| KEGG | KEGG:00730 | Thiamine metabolism | 2 | 10 | 9.67e-01 |
| KEGG | KEGG:00340 | Histidine metabolism | 2 | 10 | 9.67e-01 |
| KEGG | KEGG:00970 | Aminoacyl-tRNA biosynthesis | 8 | 42 | 9.70e-01 |
| KEGG | KEGG:00512 | Mucin type O-glycan biosynthesis | 4 | 21 | 9.70e-01 |
| KEGG | KEGG:05133 | Pertussis | 8 | 42 | 9.70e-01 |
| KEGG | KEGG:04371 | Apelin signaling pathway | 20 | 104 | 9.76e-01 |
| KEGG | KEGG:05132 | Salmonella infection | 39 | 201 | 9.86e-01 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | 19 | 100 | 9.89e-01 |
| KEGG | KEGG:04110 | Cell cycle | 28 | 146 | 9.89e-01 |
| KEGG | KEGG:00640 | Propanoate metabolism | 5 | 27 | 9.89e-01 |
| KEGG | KEGG:05162 | Measles | 16 | 85 | 9.94e-01 |
| KEGG | KEGG:00120 | Primary bile acid biosynthesis | 2 | 11 | 9.94e-01 |
| KEGG | KEGG:01232 | Nucleotide metabolism | 12 | 65 | 9.94e-01 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | 15 | 80 | 9.94e-01 |
| KEGG | KEGG:03082 | ATP-dependent chromatin remodeling | 17 | 91 | 9.94e-01 |
| KEGG | KEGG:04340 | Hedgehog signaling pathway | 9 | 49 | 9.94e-01 |
| KEGG | KEGG:03013 | Nucleocytoplasmic transport | 18 | 96 | 9.94e-01 |
| KEGG | KEGG:00565 | Ether lipid metabolism | 5 | 28 | 9.98e-01 |
| KEGG | KEGG:04512 | ECM-receptor interaction | 9 | 66 | 1.00e+00 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | 32 | 169 | 1.00e+00 |
| KEGG | KEGG:04962 | Vasopressin-regulated water reabsorption | 5 | 37 | 1.00e+00 |
| KEGG | KEGG:05208 | Chemical carcinogenesis - reactive oxygen species | 18 | 173 | 1.00e+00 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | 18 | 149 | 1.00e+00 |
| KEGG | KEGG:05415 | Diabetic cardiomyopathy | 25 | 158 | 1.00e+00 |
| KEGG | KEGG:04510 | Focal adhesion | 28 | 169 | 1.00e+00 |
| KEGG | KEGG:04932 | Non-alcoholic fatty liver disease | 17 | 126 | 1.00e+00 |
| KEGG | KEGG:04975 | Fat digestion and absorption | 2 | 18 | 1.00e+00 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | 65 | 364 | 1.00e+00 |
| KEGG | KEGG:04979 | Cholesterol metabolism | 5 | 33 | 1.00e+00 |
| KEGG | KEGG:04714 | Thermogenesis | 24 | 185 | 1.00e+00 |
| KEGG | KEGG:05016 | Huntington disease | 40 | 246 | 1.00e+00 |
| KEGG | KEGG:04710 | Circadian rhythm | 5 | 29 | 1.00e+00 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | 19 | 104 | 1.00e+00 |
| KEGG | KEGG:04723 | Retrograde endocannabinoid signaling | 16 | 92 | 1.00e+00 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | 47 | 291 | 1.00e+00 |
| KEGG | KEGG:04664 | Fc epsilon RI signaling pathway | 7 | 42 | 1.00e+00 |
| KEGG | KEGG:05012 | Parkinson disease | 31 | 211 | 1.00e+00 |
| KEGG | KEGG:05010 | Alzheimer disease | 54 | 296 | 1.00e+00 |
| KEGG | KEGG:05168 | Herpes simplex virus 1 infection | 41 | 388 | 1.00e+00 |
| KEGG | KEGG:04657 | IL-17 signaling pathway | 9 | 55 | 1.00e+00 |
| KEGG | KEGG:04623 | Cytosolic DNA-sensing pathway | 5 | 46 | 1.00e+00 |
| KEGG | KEGG:05144 | Malaria | 3 | 20 | 1.00e+00 |
| KEGG | KEGG:04622 | RIG-I-like receptor signaling pathway | 5 | 44 | 1.00e+00 |
| KEGG | KEGG:04621 | NOD-like receptor signaling pathway | 18 | 109 | 1.00e+00 |
| KEGG | KEGG:04612 | Antigen processing and presentation | 2 | 26 | 1.00e+00 |
| KEGG | KEGG:05145 | Toxoplasmosis | 9 | 72 | 1.00e+00 |
| KEGG | KEGG:04610 | Complement and coagulation cascades | 6 | 35 | 1.00e+00 |
| KEGG | KEGG:05150 | Staphylococcus aureus infection | 1 | 13 | 1.00e+00 |
| KEGG | KEGG:05020 | Prion disease | 29 | 204 | 1.00e+00 |
| KEGG | KEGG:05134 | Legionellosis | 3 | 34 | 1.00e+00 |
| KEGG | KEGG:05219 | Bladder cancer | 6 | 35 | 1.00e+00 |
| KEGG | KEGG:04146 | Peroxisome | 10 | 66 | 1.00e+00 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | 20 | 109 | 1.00e+00 |
| KEGG | KEGG:00860 | Porphyrin metabolism | 1 | 18 | 1.00e+00 |
| KEGG | KEGG:00900 | Terpenoid backbone biosynthesis | 2 | 21 | 1.00e+00 |
| KEGG | KEGG:00140 | Steroid hormone biosynthesis | 2 | 16 | 1.00e+00 |
| KEGG | KEGG:00920 | Sulfur metabolism | 1 | 10 | 1.00e+00 |
| KEGG | KEGG:00100 | Steroid biosynthesis | 1 | 15 | 1.00e+00 |
| KEGG | KEGG:00983 | Drug metabolism - other enzymes | 6 | 40 | 1.00e+00 |
| KEGG | KEGG:00071 | Fatty acid degradation | 2 | 31 | 1.00e+00 |
| KEGG | KEGG:01100 | Metabolic pathways | 195 | 1077 | 1.00e+00 |
| KEGG | KEGG:00062 | Fatty acid elongation | 2 | 22 | 1.00e+00 |
| KEGG | KEGG:00040 | Pentose and glucuronate interconversions | 1 | 11 | 1.00e+00 |
| KEGG | KEGG:01200 | Carbon metabolism | 11 | 88 | 1.00e+00 |
| KEGG | KEGG:00030 | Pentose phosphate pathway | 3 | 20 | 1.00e+00 |
| KEGG | KEGG:01210 | 2-Oxocarboxylic acid metabolism | 2 | 26 | 1.00e+00 |
| KEGG | KEGG:01212 | Fatty acid metabolism | 6 | 46 | 1.00e+00 |
| KEGG | KEGG:00430 | Taurine and hypotaurine metabolism | 1 | 8 | 1.00e+00 |
| KEGG | KEGG:01240 | Biosynthesis of cofactors | 16 | 109 | 1.00e+00 |
| KEGG | KEGG:01250 | Biosynthesis of nucleotide sugars | 5 | 34 | 1.00e+00 |
| KEGG | KEGG:00020 | Citrate cycle (TCA cycle) | 1 | 26 | 1.00e+00 |
| KEGG | KEGG:01523 | Antifolate resistance | 2 | 22 | 1.00e+00 |
| KEGG | KEGG:03008 | Ribosome biogenesis in eukaryotes | 5 | 65 | 1.00e+00 |
| KEGG | KEGG:03010 | Ribosome | 7 | 121 | 1.00e+00 |
| KEGG | KEGG:00790 | Folate biosynthesis | 2 | 18 | 1.00e+00 |
| KEGG | KEGG:00785 | Lipoic acid metabolism | 2 | 16 | 1.00e+00 |
| KEGG | KEGG:00190 | Oxidative phosphorylation | 6 | 99 | 1.00e+00 |
| KEGG | KEGG:00760 | Nicotinate and nicotinamide metabolism | 4 | 28 | 1.00e+00 |
| KEGG | KEGG:00480 | Glutathione metabolism | 3 | 39 | 1.00e+00 |
| KEGG | KEGG:00510 | N-Glycan biosynthesis | 5 | 49 | 1.00e+00 |
| KEGG | KEGG:00511 | Other glycan degradation | 1 | 14 | 1.00e+00 |
| KEGG | KEGG:00513 | Various types of N-glycan biosynthesis | 4 | 37 | 1.00e+00 |
| KEGG | KEGG:00520 | Amino sugar and nucleotide sugar metabolism | 5 | 44 | 1.00e+00 |
| KEGG | KEGG:00330 | Arginine and proline metabolism | 5 | 33 | 1.00e+00 |
| KEGG | KEGG:00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 2 | 13 | 1.00e+00 |
| KEGG | KEGG:00310 | Lysine degradation | 10 | 56 | 1.00e+00 |
| KEGG | KEGG:00561 | Glycerolipid metabolism | 7 | 44 | 1.00e+00 |
| KEGG | KEGG:00563 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 2 | 23 | 1.00e+00 |
| KEGG | KEGG:03015 | mRNA surveillance pathway | 13 | 80 | 1.00e+00 |
| KEGG | KEGG:00590 | Arachidonic acid metabolism | 4 | 25 | 1.00e+00 |
| KEGG | KEGG:00603 | Glycosphingolipid biosynthesis - globo and isoglobo series | 1 | 8 | 1.00e+00 |
| KEGG | KEGG:00604 | Glycosphingolipid biosynthesis - ganglio series | 1 | 12 | 1.00e+00 |
| KEGG | KEGG:00620 | Pyruvate metabolism | 4 | 31 | 1.00e+00 |
| KEGG | KEGG:00630 | Glyoxylate and dicarboxylate metabolism | 2 | 25 | 1.00e+00 |
| KEGG | KEGG:00260 | Glycine, serine and threonine metabolism | 3 | 26 | 1.00e+00 |
| KEGG | KEGG:00250 | Alanine, aspartate and glutamate metabolism | 3 | 28 | 1.00e+00 |
| KEGG | KEGG:00650 | Butanoate metabolism | 2 | 17 | 1.00e+00 |
| KEGG | KEGG:00240 | Pyrimidine metabolism | 5 | 44 | 1.00e+00 |
| KEGG | KEGG:00670 | One carbon pool by folate | 1 | 18 | 1.00e+00 |
| KEGG | KEGG:00740 | Riboflavin metabolism | 1 | 6 | 1.00e+00 |
| KEGG | KEGG:00280 | Valine, leucine and isoleucine degradation | 4 | 42 | 1.00e+00 |
| KEGG | KEGG:03018 | RNA degradation | 6 | 67 | 1.00e+00 |
| KEGG | KEGG:01230 | Biosynthesis of amino acids | 6 | 52 | 1.00e+00 |
| KEGG | KEGG:03022 | Basal transcription factors | 5 | 33 | 1.00e+00 |
| KEGG | KEGG:04215 | Apoptosis - multiple species | 5 | 29 | 1.00e+00 |
| KEGG | KEGG:04142 | Lysosome | 15 | 109 | 1.00e+00 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | 21 | 149 | 1.00e+00 |
| KEGG | KEGG:04137 | Mitophagy - animal | 15 | 94 | 1.00e+00 |
| KEGG | KEGG:04122 | Sulfur relay system | 1 | 8 | 1.00e+00 |
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | 23 | 127 | 1.00e+00 |
| KEGG | KEGG:03020 | RNA polymerase | 4 | 33 | 1.00e+00 |
| KEGG | KEGG:03460 | Fanconi anemia pathway | 8 | 46 | 1.00e+00 |
| KEGG | KEGG:03440 | Homologous recombination | 6 | 38 | 1.00e+00 |
| KEGG | KEGG:00450 | Selenocompound metabolism | 2 | 14 | 1.00e+00 |
| KEGG | KEGG:03060 | Protein export | 2 | 28 | 1.00e+00 |
| KEGG | KEGG:00010 | Glycolysis / Gluconeogenesis | 6 | 41 | 1.00e+00 |
| KEGG | KEGG:03266 | Virion - Herpesvirus | 1 | 6 | 1.00e+00 |
| KEGG | KEGG:03040 | Spliceosome | 10 | 124 | 1.00e+00 |
| KEGG | KEGG:03050 | Proteasome | 5 | 40 | 1.00e+00 |
ESR_int_restable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
slice_head(n=10) %>%
mutate(log10_p=(-log(p_value, base=10))) %>%
ggplot(., aes(x=log10_p, y=reorder(term_name, log10_p)))+
geom_col(fill="#7CAE00")+
theme_bw()+
ylab("")+
xlab(paste0("-log10 p-value"))+
guides(fill="none")+
theme(axis.text.y = element_text(color="black"))+
ggtitle("Intersection ESR")
LR
# LR_int_resgenes <- gost(query = int_LR_n_RNAresp,
# organism = "hsapiens",
# significant = FALSE,
# ordered_query = FALSE,
# domain_scope = "custom",
# measure_underrepresentation = FALSE,
# evcodes = FALSE,
# user_threshold = 0.05,
# correction_method = c("fdr"),
# custom_bg = background_df$ENTREZID,
# sources=c("GO:BP","KEGG"))
# saveRDS(LR_int_resgenes,"data/GO_KEGG_analysis/LR_int_resgenes.RDS")
LR_int_restable <- LR_int_resgenes$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
LR_int_restable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in LR neargenes intersected with RNA response genes" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0051716 | cellular response to stimulus | 1660 | 4640 | 5.46e-18 |
| GO:BP | GO:0050896 | response to stimulus | 1879 | 5379 | 1.95e-16 |
| GO:BP | GO:0007154 | cell communication | 1439 | 3983 | 1.95e-16 |
| GO:BP | GO:0023052 | signaling | 1413 | 3918 | 1.02e-15 |
| GO:BP | GO:0007165 | signal transduction | 1313 | 3611 | 1.40e-15 |
| GO:BP | GO:0032501 | multicellular organismal process | 1596 | 4504 | 2.20e-15 |
| GO:BP | GO:0050794 | regulation of cellular process | 2401 | 7153 | 6.11e-14 |
| GO:BP | GO:0007275 | multicellular organism development | 1153 | 3170 | 4.23e-13 |
| GO:BP | GO:0032502 | developmental process | 1477 | 4179 | 4.23e-13 |
| GO:BP | GO:0048869 | cellular developmental process | 1034 | 2804 | 4.23e-13 |
| GO:BP | GO:0050789 | regulation of biological process | 2502 | 7516 | 4.50e-13 |
| GO:BP | GO:0030154 | cell differentiation | 1033 | 2803 | 4.50e-13 |
| GO:BP | GO:0048518 | positive regulation of biological process | 1514 | 4301 | 4.52e-13 |
| GO:BP | GO:0065007 | biological regulation | 2565 | 7734 | 7.27e-13 |
| GO:BP | GO:0048731 | system development | 1002 | 2719 | 1.21e-12 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 1400 | 3954 | 1.34e-12 |
| GO:BP | GO:0048856 | anatomical structure development | 1372 | 3867 | 1.39e-12 |
| GO:BP | GO:0048519 | negative regulation of biological process | 1335 | 3764 | 5.10e-12 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 1265 | 3550 | 8.05e-12 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 703 | 1844 | 2.67e-11 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 727 | 1924 | 7.75e-11 |
| GO:BP | GO:0010646 | regulation of cell communication | 895 | 2444 | 3.36e-10 |
| GO:BP | GO:0048513 | animal organ development | 749 | 2004 | 4.17e-10 |
| GO:BP | GO:0048468 | cell development | 709 | 1886 | 5.16e-10 |
| GO:BP | GO:0050793 | regulation of developmental process | 644 | 1697 | 9.53e-10 |
| GO:BP | GO:0023051 | regulation of signaling | 888 | 2438 | 1.58e-09 |
| GO:BP | GO:0009966 | regulation of signal transduction | 798 | 2166 | 1.88e-09 |
| GO:BP | GO:0048583 | regulation of response to stimulus | 978 | 2717 | 2.01e-09 |
| GO:BP | GO:0009888 | tissue development | 522 | 1348 | 4.03e-09 |
| GO:BP | GO:0035556 | intracellular signal transduction | 724 | 1951 | 4.67e-09 |
| GO:BP | GO:0072359 | circulatory system development | 352 | 864 | 1.31e-08 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | 669 | 1801 | 2.75e-08 |
| GO:BP | GO:0141124 | intracellular signaling cassette | 502 | 1314 | 1.05e-07 |
| GO:BP | GO:0048589 | developmental growth | 218 | 501 | 1.10e-07 |
| GO:BP | GO:0051094 | positive regulation of developmental process | 364 | 913 | 1.28e-07 |
| GO:BP | GO:0048646 | anatomical structure formation involved in morphogenesis | 336 | 837 | 2.52e-07 |
| GO:BP | GO:0051240 | positive regulation of multicellular organismal process | 406 | 1040 | 2.70e-07 |
| GO:BP | GO:0008283 | cell population proliferation | 495 | 1306 | 4.69e-07 |
| GO:BP | GO:0007399 | nervous system development | 651 | 1775 | 5.48e-07 |
| GO:BP | GO:0022008 | neurogenesis | 475 | 1251 | 7.62e-07 |
| GO:BP | GO:0014706 | striated muscle tissue development | 106 | 213 | 8.14e-07 |
| GO:BP | GO:0030900 | forebrain development | 128 | 272 | 1.71e-06 |
| GO:BP | GO:0044057 | regulation of system process | 170 | 384 | 1.80e-06 |
| GO:BP | GO:0048699 | generation of neurons | 411 | 1076 | 4.17e-06 |
| GO:BP | GO:0003008 | system process | 432 | 1139 | 4.63e-06 |
| GO:BP | GO:0007507 | heart development | 210 | 499 | 4.94e-06 |
| GO:BP | GO:0048738 | cardiac muscle tissue development | 98 | 201 | 1.03e-05 |
| GO:BP | GO:0060419 | heart growth | 44 | 71 | 1.03e-05 |
| GO:BP | GO:1901699 | cellular response to nitrogen compound | 201 | 479 | 1.22e-05 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | 408 | 1077 | 1.28e-05 |
| GO:BP | GO:0045597 | positive regulation of cell differentiation | 240 | 591 | 1.70e-05 |
| GO:BP | GO:0071417 | cellular response to organonitrogen compound | 187 | 442 | 1.70e-05 |
| GO:BP | GO:1902531 | regulation of intracellular signal transduction | 478 | 1289 | 1.84e-05 |
| GO:BP | GO:0045595 | regulation of cell differentiation | 405 | 1073 | 2.16e-05 |
| GO:BP | GO:0060322 | head development | 221 | 539 | 2.18e-05 |
| GO:BP | GO:0009887 | animal organ morphogenesis | 268 | 673 | 2.18e-05 |
| GO:BP | GO:0040007 | growth | 276 | 697 | 2.49e-05 |
| GO:BP | GO:0035295 | tube development | 307 | 787 | 2.54e-05 |
| GO:BP | GO:0009893 | positive regulation of metabolic process | 911 | 2622 | 2.86e-05 |
| GO:BP | GO:0003013 | circulatory system process | 180 | 426 | 2.86e-05 |
| GO:BP | GO:0035239 | tube morphogenesis | 255 | 638 | 2.86e-05 |
| GO:BP | GO:0021537 | telencephalon development | 94 | 195 | 2.90e-05 |
| GO:BP | GO:0060537 | muscle tissue development | 148 | 339 | 3.33e-05 |
| GO:BP | GO:0007417 | central nervous system development | 274 | 694 | 3.35e-05 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | 429 | 1150 | 3.49e-05 |
| GO:BP | GO:0007267 | cell-cell signaling | 406 | 1082 | 3.64e-05 |
| GO:BP | GO:0007010 | cytoskeleton organization | 427 | 1146 | 4.24e-05 |
| GO:BP | GO:0030030 | cell projection organization | 439 | 1182 | 4.25e-05 |
| GO:BP | GO:0008015 | blood circulation | 154 | 357 | 4.29e-05 |
| GO:BP | GO:0120035 | regulation of plasma membrane bounded cell projection organization | 207 | 505 | 4.46e-05 |
| GO:BP | GO:2000026 | regulation of multicellular organismal development | 361 | 951 | 4.46e-05 |
| GO:BP | GO:0051093 | negative regulation of developmental process | 248 | 622 | 4.56e-05 |
| GO:BP | GO:0070887 | cellular response to chemical stimulus | 626 | 1751 | 5.38e-05 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 662 | 1862 | 5.59e-05 |
| GO:BP | GO:0035265 | organ growth | 66 | 127 | 5.59e-05 |
| GO:BP | GO:0006950 | response to stress | 881 | 2540 | 5.69e-05 |
| GO:BP | GO:0031344 | regulation of cell projection organization | 210 | 516 | 6.22e-05 |
| GO:BP | GO:0048638 | regulation of developmental growth | 111 | 243 | 6.22e-05 |
| GO:BP | GO:0030182 | neuron differentiation | 381 | 1014 | 6.36e-05 |
| GO:BP | GO:0051241 | negative regulation of multicellular organismal process | 276 | 706 | 6.58e-05 |
| GO:BP | GO:0034330 | cell junction organization | 220 | 545 | 6.58e-05 |
| GO:BP | GO:0055017 | cardiac muscle tissue growth | 39 | 64 | 6.61e-05 |
| GO:BP | GO:0060420 | regulation of heart growth | 32 | 49 | 7.47e-05 |
| GO:BP | GO:0042221 | response to chemical | 802 | 2304 | 1.12e-04 |
| GO:BP | GO:0033002 | muscle cell proliferation | 75 | 152 | 1.18e-04 |
| GO:BP | GO:0016477 | cell migration | 378 | 1011 | 1.18e-04 |
| GO:BP | GO:0007420 | brain development | 202 | 498 | 1.22e-04 |
| GO:BP | GO:0001568 | blood vessel development | 211 | 525 | 1.51e-04 |
| GO:BP | GO:0014855 | striated muscle cell proliferation | 36 | 59 | 1.60e-04 |
| GO:BP | GO:0032879 | regulation of localization | 519 | 1439 | 1.65e-04 |
| GO:BP | GO:0001944 | vasculature development | 220 | 552 | 1.77e-04 |
| GO:BP | GO:0031325 | positive regulation of cellular metabolic process | 809 | 2333 | 1.79e-04 |
| GO:BP | GO:0045165 | cell fate commitment | 74 | 151 | 1.79e-04 |
| GO:BP | GO:0099537 | trans-synaptic signaling | 190 | 467 | 1.87e-04 |
| GO:BP | GO:0090257 | regulation of muscle system process | 84 | 177 | 1.91e-04 |
| GO:BP | GO:1901653 | cellular response to peptide | 120 | 273 | 2.05e-04 |
| GO:BP | GO:0071495 | cellular response to endogenous stimulus | 384 | 1035 | 2.06e-04 |
| GO:BP | GO:0071310 | cellular response to organic substance | 471 | 1297 | 2.13e-04 |
| GO:BP | GO:0006915 | apoptotic process | 497 | 1377 | 2.34e-04 |
| GO:BP | GO:0008016 | regulation of heart contraction | 79 | 165 | 2.34e-04 |
| GO:BP | GO:1901701 | cellular response to oxygen-containing compound | 303 | 796 | 2.34e-04 |
| GO:BP | GO:0007167 | enzyme-linked receptor protein signaling pathway | 276 | 717 | 2.34e-04 |
| GO:BP | GO:0016310 | phosphorylation | 420 | 1145 | 2.43e-04 |
| GO:BP | GO:0060562 | epithelial tube morphogenesis | 115 | 261 | 2.68e-04 |
| GO:BP | GO:0060429 | epithelium development | 301 | 792 | 2.80e-04 |
| GO:BP | GO:0031175 | neuron projection development | 284 | 743 | 3.14e-04 |
| GO:BP | GO:0003012 | muscle system process | 138 | 325 | 3.23e-04 |
| GO:BP | GO:0065008 | regulation of biological quality | 664 | 1893 | 3.23e-04 |
| GO:BP | GO:0007268 | chemical synaptic transmission | 187 | 463 | 3.38e-04 |
| GO:BP | GO:0098916 | anterograde trans-synaptic signaling | 187 | 463 | 3.38e-04 |
| GO:BP | GO:0099536 | synaptic signaling | 194 | 483 | 3.38e-04 |
| GO:BP | GO:0046620 | regulation of organ growth | 40 | 70 | 3.51e-04 |
| GO:BP | GO:0009790 | embryo development | 310 | 821 | 3.51e-04 |
| GO:BP | GO:0030029 | actin filament-based process | 248 | 640 | 3.94e-04 |
| GO:BP | GO:0048729 | tissue morphogenesis | 183 | 453 | 4.05e-04 |
| GO:BP | GO:0009719 | response to endogenous stimulus | 435 | 1197 | 4.30e-04 |
| GO:BP | GO:0048666 | neuron development | 315 | 838 | 4.40e-04 |
| GO:BP | GO:0012501 | programmed cell death | 508 | 1419 | 4.41e-04 |
| GO:BP | GO:0010975 | regulation of neuron projection development | 148 | 355 | 4.43e-04 |
| GO:BP | GO:0008219 | cell death | 509 | 1423 | 4.73e-04 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | 391 | 1067 | 5.37e-04 |
| GO:BP | GO:0055021 | regulation of cardiac muscle tissue growth | 28 | 44 | 5.54e-04 |
| GO:BP | GO:0040011 | locomotion | 303 | 805 | 5.65e-04 |
| GO:BP | GO:1901652 | response to peptide | 152 | 368 | 5.89e-04 |
| GO:BP | GO:0040012 | regulation of locomotion | 274 | 720 | 5.96e-04 |
| GO:BP | GO:0051056 | regulation of small GTPase mediated signal transduction | 103 | 233 | 6.10e-04 |
| GO:BP | GO:0048870 | cell motility | 408 | 1120 | 6.15e-04 |
| GO:BP | GO:2000145 | regulation of cell motility | 267 | 700 | 6.26e-04 |
| GO:BP | GO:0030334 | regulation of cell migration | 256 | 668 | 6.43e-04 |
| GO:BP | GO:0001503 | ossification | 128 | 302 | 6.69e-04 |
| GO:BP | GO:0022603 | regulation of anatomical structure morphogenesis | 235 | 609 | 8.60e-04 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 419 | 1157 | 8.60e-04 |
| GO:BP | GO:0048598 | embryonic morphogenesis | 170 | 422 | 9.25e-04 |
| GO:BP | GO:1901698 | response to nitrogen compound | 278 | 736 | 9.32e-04 |
| GO:BP | GO:0045444 | fat cell differentiation | 82 | 179 | 9.74e-04 |
| GO:BP | GO:0010604 | positive regulation of macromolecule metabolic process | 826 | 2415 | 9.89e-04 |
| GO:BP | GO:0009968 | negative regulation of signal transduction | 357 | 972 | 9.90e-04 |
| GO:BP | GO:0033554 | cellular response to stress | 509 | 1433 | 9.96e-04 |
| GO:BP | GO:0006468 | protein phosphorylation | 352 | 958 | 1.08e-03 |
| GO:BP | GO:0016043 | cellular component organization | 1575 | 4802 | 1.13e-03 |
| GO:BP | GO:0003015 | heart process | 91 | 204 | 1.19e-03 |
| GO:BP | GO:0035108 | limb morphogenesis | 55 | 110 | 1.19e-03 |
| GO:BP | GO:0035107 | appendage morphogenesis | 55 | 110 | 1.19e-03 |
| GO:BP | GO:0044089 | positive regulation of cellular component biogenesis | 158 | 390 | 1.21e-03 |
| GO:BP | GO:0030097 | hemopoiesis | 239 | 624 | 1.21e-03 |
| GO:BP | GO:0006796 | phosphate-containing compound metabolic process | 654 | 1883 | 1.23e-03 |
| GO:BP | GO:0060047 | heart contraction | 87 | 194 | 1.36e-03 |
| GO:BP | GO:0010647 | positive regulation of cell communication | 437 | 1218 | 1.40e-03 |
| GO:BP | GO:0002009 | morphogenesis of an epithelium | 150 | 369 | 1.54e-03 |
| GO:BP | GO:0014745 | negative regulation of muscle adaptation | 9 | 9 | 1.74e-03 |
| GO:BP | GO:0006793 | phosphorus metabolic process | 659 | 1904 | 1.77e-03 |
| GO:BP | GO:0023056 | positive regulation of signaling | 437 | 1221 | 1.77e-03 |
| GO:BP | GO:1902893 | regulation of miRNA transcription | 34 | 60 | 1.77e-03 |
| GO:BP | GO:0042592 | homeostatic process | 409 | 1137 | 1.94e-03 |
| GO:BP | GO:0002521 | leukocyte differentiation | 150 | 371 | 2.07e-03 |
| GO:BP | GO:0048585 | negative regulation of response to stimulus | 427 | 1193 | 2.16e-03 |
| GO:BP | GO:0044087 | regulation of cellular component biogenesis | 282 | 757 | 2.30e-03 |
| GO:BP | GO:0045596 | negative regulation of cell differentiation | 178 | 452 | 2.31e-03 |
| GO:BP | GO:1903522 | regulation of blood circulation | 86 | 194 | 2.37e-03 |
| GO:BP | GO:0009891 | positive regulation of biosynthetic process | 642 | 1856 | 2.39e-03 |
| GO:BP | GO:0010033 | response to organic substance | 603 | 1736 | 2.54e-03 |
| GO:BP | GO:0061614 | miRNA transcription | 34 | 61 | 2.63e-03 |
| GO:BP | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 179 | 456 | 2.63e-03 |
| GO:BP | GO:0086065 | cell communication involved in cardiac conduction | 31 | 54 | 2.63e-03 |
| GO:BP | GO:0010243 | response to organonitrogen compound | 257 | 685 | 2.81e-03 |
| GO:BP | GO:0023057 | negative regulation of signaling | 374 | 1036 | 2.90e-03 |
| GO:BP | GO:0048568 | embryonic organ development | 125 | 303 | 3.01e-03 |
| GO:BP | GO:0086004 | regulation of cardiac muscle cell contraction | 21 | 32 | 3.04e-03 |
| GO:BP | GO:0001764 | neuron migration | 61 | 129 | 3.10e-03 |
| GO:BP | GO:0010648 | negative regulation of cell communication | 373 | 1034 | 3.10e-03 |
| GO:BP | GO:0008285 | negative regulation of cell population proliferation | 183 | 469 | 3.10e-03 |
| GO:BP | GO:0035148 | tube formation | 59 | 124 | 3.24e-03 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | 350 | 965 | 3.24e-03 |
| GO:BP | GO:0051173 | positive regulation of nitrogen compound metabolic process | 746 | 2186 | 3.28e-03 |
| GO:BP | GO:0048639 | positive regulation of developmental growth | 57 | 119 | 3.37e-03 |
| GO:BP | GO:0009967 | positive regulation of signal transduction | 392 | 1093 | 3.41e-03 |
| GO:BP | GO:0007423 | sensory organ development | 154 | 387 | 3.74e-03 |
| GO:BP | GO:0016331 | morphogenesis of embryonic epithelium | 58 | 122 | 3.74e-03 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | 352 | 973 | 3.76e-03 |
| GO:BP | GO:0021953 | central nervous system neuron differentiation | 49 | 99 | 3.78e-03 |
| GO:BP | GO:0007155 | cell adhesion | 341 | 941 | 4.18e-03 |
| GO:BP | GO:2000628 | regulation of miRNA metabolic process | 38 | 72 | 4.28e-03 |
| GO:BP | GO:0007049 | cell cycle | 503 | 1436 | 4.37e-03 |
| GO:BP | GO:0048584 | positive regulation of response to stimulus | 525 | 1504 | 4.41e-03 |
| GO:BP | GO:0034329 | cell junction assembly | 131 | 323 | 4.60e-03 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | 567 | 1635 | 4.77e-03 |
| GO:BP | GO:0071375 | cellular response to peptide hormone stimulus | 98 | 231 | 4.94e-03 |
| GO:BP | GO:0031324 | negative regulation of cellular metabolic process | 663 | 1934 | 4.94e-03 |
| GO:BP | GO:0048514 | blood vessel morphogenesis | 175 | 450 | 4.98e-03 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | 716 | 2100 | 5.01e-03 |
| GO:BP | GO:0048167 | regulation of synaptic plasticity | 64 | 139 | 5.01e-03 |
| GO:BP | GO:0061337 | cardiac conduction | 43 | 85 | 5.16e-03 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | 668 | 1951 | 5.29e-03 |
| GO:BP | GO:0086001 | cardiac muscle cell action potential | 34 | 63 | 5.30e-03 |
| GO:BP | GO:1901700 | response to oxygen-containing compound | 390 | 1093 | 5.30e-03 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | 551 | 1588 | 5.45e-03 |
| GO:BP | GO:0071496 | cellular response to external stimulus | 111 | 268 | 5.49e-03 |
| GO:BP | GO:0032101 | regulation of response to external stimulus | 244 | 654 | 5.56e-03 |
| GO:BP | GO:0060043 | regulation of cardiac muscle cell proliferation | 20 | 31 | 5.58e-03 |
| GO:BP | GO:0045598 | regulation of fat cell differentiation | 46 | 93 | 5.77e-03 |
| GO:BP | GO:0030282 | bone mineralization | 40 | 78 | 5.84e-03 |
| GO:BP | GO:0031328 | positive regulation of cellular biosynthetic process | 632 | 1841 | 5.87e-03 |
| GO:BP | GO:0051172 | negative regulation of nitrogen compound metabolic process | 565 | 1633 | 5.92e-03 |
| GO:BP | GO:0043434 | response to peptide hormone | 127 | 314 | 6.11e-03 |
| GO:BP | GO:0061351 | neural precursor cell proliferation | 56 | 119 | 6.11e-03 |
| GO:BP | GO:0043010 | camera-type eye development | 97 | 230 | 6.38e-03 |
| GO:BP | GO:0051129 | negative regulation of cellular component organization | 210 | 555 | 6.39e-03 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | 221 | 588 | 6.72e-03 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 260 | 704 | 6.72e-03 |
| GO:BP | GO:0000902 | cell morphogenesis | 263 | 713 | 6.72e-03 |
| GO:BP | GO:0014856 | skeletal muscle cell proliferation | 13 | 17 | 6.72e-03 |
| GO:BP | GO:2000629 | negative regulation of miRNA metabolic process | 17 | 25 | 6.72e-03 |
| GO:BP | GO:0014741 | negative regulation of muscle hypertrophy | 17 | 25 | 6.72e-03 |
| GO:BP | GO:0061049 | cell growth involved in cardiac muscle cell development | 14 | 19 | 6.93e-03 |
| GO:BP | GO:0072175 | epithelial tube formation | 55 | 117 | 6.93e-03 |
| GO:BP | GO:0003338 | metanephros morphogenesis | 14 | 19 | 6.93e-03 |
| GO:BP | GO:0003301 | physiological cardiac muscle hypertrophy | 14 | 19 | 6.93e-03 |
| GO:BP | GO:1902894 | negative regulation of miRNA transcription | 16 | 23 | 6.93e-03 |
| GO:BP | GO:0003298 | physiological muscle hypertrophy | 14 | 19 | 6.93e-03 |
| GO:BP | GO:0031327 | negative regulation of cellular biosynthetic process | 561 | 1624 | 6.97e-03 |
| GO:BP | GO:0042100 | B cell proliferation | 26 | 45 | 7.00e-03 |
| GO:BP | GO:0061180 | mammary gland epithelium development | 29 | 52 | 7.00e-03 |
| GO:BP | GO:0086003 | cardiac muscle cell contraction | 34 | 64 | 7.00e-03 |
| GO:BP | GO:0042981 | regulation of apoptotic process | 368 | 1031 | 7.12e-03 |
| GO:BP | GO:0044093 | positive regulation of molecular function | 286 | 783 | 7.12e-03 |
| GO:BP | GO:0014897 | striated muscle hypertrophy | 38 | 74 | 7.39e-03 |
| GO:BP | GO:0060173 | limb development | 62 | 136 | 7.46e-03 |
| GO:BP | GO:0030036 | actin cytoskeleton organization | 213 | 566 | 7.46e-03 |
| GO:BP | GO:0032147 | activation of protein kinase activity | 31 | 57 | 7.46e-03 |
| GO:BP | GO:0031323 | regulation of cellular metabolic process | 1384 | 4233 | 7.46e-03 |
| GO:BP | GO:0048736 | appendage development | 62 | 136 | 7.46e-03 |
| GO:BP | GO:0002682 | regulation of immune system process | 314 | 868 | 7.46e-03 |
| GO:BP | GO:0010586 | miRNA metabolic process | 43 | 87 | 8.33e-03 |
| GO:BP | GO:0030326 | embryonic limb morphogenesis | 43 | 87 | 8.33e-03 |
| GO:BP | GO:0035113 | embryonic appendage morphogenesis | 43 | 87 | 8.33e-03 |
| GO:BP | GO:0050808 | synapse organization | 134 | 337 | 8.58e-03 |
| GO:BP | GO:0007186 | G protein-coupled receptor signaling pathway | 151 | 386 | 8.62e-03 |
| GO:BP | GO:0048771 | tissue remodeling | 53 | 113 | 8.82e-03 |
| GO:BP | GO:0099177 | regulation of trans-synaptic signaling | 129 | 323 | 8.87e-03 |
| GO:BP | GO:0007389 | pattern specification process | 116 | 286 | 8.87e-03 |
| GO:BP | GO:0010557 | positive regulation of macromolecule biosynthetic process | 613 | 1791 | 9.14e-03 |
| GO:BP | GO:0048871 | multicellular organismal-level homeostasis | 202 | 536 | 9.43e-03 |
| GO:BP | GO:0061061 | muscle structure development | 202 | 536 | 9.43e-03 |
| GO:BP | GO:1903829 | positive regulation of protein localization | 150 | 384 | 9.46e-03 |
| GO:BP | GO:0016055 | Wnt signaling pathway | 141 | 358 | 9.46e-03 |
| GO:BP | GO:0002376 | immune system process | 490 | 1410 | 9.47e-03 |
| GO:BP | GO:0009605 | response to external stimulus | 538 | 1559 | 9.67e-03 |
| GO:BP | GO:0014896 | muscle hypertrophy | 38 | 75 | 9.67e-03 |
| GO:BP | GO:1902532 | negative regulation of intracellular signal transduction | 166 | 431 | 9.99e-03 |
| GO:BP | GO:0031347 | regulation of defense response | 172 | 449 | 1.06e-02 |
| GO:BP | GO:0060421 | positive regulation of heart growth | 18 | 28 | 1.06e-02 |
| GO:BP | GO:0046661 | male sex differentiation | 50 | 106 | 1.06e-02 |
| GO:BP | GO:0198738 | cell-cell signaling by wnt | 141 | 359 | 1.06e-02 |
| GO:BP | GO:0060008 | Sertoli cell differentiation | 10 | 12 | 1.08e-02 |
| GO:BP | GO:0072087 | renal vesicle development | 10 | 12 | 1.08e-02 |
| GO:BP | GO:0042391 | regulation of membrane potential | 114 | 282 | 1.10e-02 |
| GO:BP | GO:0050804 | modulation of chemical synaptic transmission | 128 | 322 | 1.10e-02 |
| GO:BP | GO:0043502 | regulation of muscle adaptation | 35 | 68 | 1.10e-02 |
| GO:BP | GO:1903115 | regulation of actin filament-based movement | 22 | 37 | 1.10e-02 |
| GO:BP | GO:0001775 | cell activation | 232 | 627 | 1.10e-02 |
| GO:BP | GO:0003300 | cardiac muscle hypertrophy | 37 | 73 | 1.10e-02 |
| GO:BP | GO:0086064 | cell communication by electrical coupling involved in cardiac conduction | 17 | 26 | 1.12e-02 |
| GO:BP | GO:0032943 | mononuclear cell proliferation | 69 | 157 | 1.12e-02 |
| GO:BP | GO:0007015 | actin filament organization | 140 | 357 | 1.15e-02 |
| GO:BP | GO:0043408 | regulation of MAPK cascade | 164 | 427 | 1.19e-02 |
| GO:BP | GO:0071875 | adrenergic receptor signaling pathway | 16 | 24 | 1.20e-02 |
| GO:BP | GO:0010614 | negative regulation of cardiac muscle hypertrophy | 16 | 24 | 1.20e-02 |
| GO:BP | GO:0022402 | cell cycle process | 363 | 1024 | 1.21e-02 |
| GO:BP | GO:0032970 | regulation of actin filament-based process | 120 | 300 | 1.21e-02 |
| GO:BP | GO:0042692 | muscle cell differentiation | 128 | 323 | 1.22e-02 |
| GO:BP | GO:0030098 | lymphocyte differentiation | 102 | 249 | 1.22e-02 |
| GO:BP | GO:0006271 | DNA strand elongation involved in DNA replication | 11 | 14 | 1.22e-02 |
| GO:BP | GO:0061117 | negative regulation of heart growth | 12 | 16 | 1.29e-02 |
| GO:BP | GO:1902680 | positive regulation of RNA biosynthetic process | 431 | 1234 | 1.29e-02 |
| GO:BP | GO:0055022 | negative regulation of cardiac muscle tissue growth | 12 | 16 | 1.29e-02 |
| GO:BP | GO:0086014 | atrial cardiac muscle cell action potential | 12 | 16 | 1.29e-02 |
| GO:BP | GO:0021879 | forebrain neuron differentiation | 14 | 20 | 1.29e-02 |
| GO:BP | GO:0002683 | negative regulation of immune system process | 118 | 295 | 1.29e-02 |
| GO:BP | GO:0086066 | atrial cardiac muscle cell to AV node cell communication | 12 | 16 | 1.29e-02 |
| GO:BP | GO:0019222 | regulation of metabolic process | 1494 | 4603 | 1.29e-02 |
| GO:BP | GO:0007264 | small GTPase-mediated signal transduction | 151 | 390 | 1.29e-02 |
| GO:BP | GO:0086026 | atrial cardiac muscle cell to AV node cell signaling | 12 | 16 | 1.29e-02 |
| GO:BP | GO:0045893 | positive regulation of DNA-templated transcription | 430 | 1231 | 1.29e-02 |
| GO:BP | GO:0045017 | glycerolipid biosynthetic process | 85 | 202 | 1.29e-02 |
| GO:BP | GO:1903131 | mononuclear cell differentiation | 112 | 278 | 1.30e-02 |
| GO:BP | GO:0001501 | skeletal system development | 136 | 347 | 1.33e-02 |
| GO:BP | GO:0043067 | regulation of programmed cell death | 374 | 1060 | 1.37e-02 |
| GO:BP | GO:0030278 | regulation of ossification | 39 | 79 | 1.38e-02 |
| GO:BP | GO:0045600 | positive regulation of fat cell differentiation | 26 | 47 | 1.40e-02 |
| GO:BP | GO:0001823 | mesonephros development | 37 | 74 | 1.40e-02 |
| GO:BP | GO:0006974 | DNA damage response | 270 | 745 | 1.49e-02 |
| GO:BP | GO:0070252 | actin-mediated cell contraction | 42 | 87 | 1.51e-02 |
| GO:BP | GO:0051254 | positive regulation of RNA metabolic process | 469 | 1354 | 1.52e-02 |
| GO:BP | GO:0040008 | regulation of growth | 175 | 462 | 1.52e-02 |
| GO:BP | GO:0045321 | leukocyte activation | 198 | 530 | 1.53e-02 |
| GO:BP | GO:0021954 | central nervous system neuron development | 30 | 57 | 1.58e-02 |
| GO:BP | GO:0003205 | cardiac chamber development | 66 | 151 | 1.60e-02 |
| GO:BP | GO:0098900 | regulation of action potential | 22 | 38 | 1.61e-02 |
| GO:BP | GO:0046474 | glycerophospholipid biosynthetic process | 74 | 173 | 1.61e-02 |
| GO:BP | GO:0043009 | chordate embryonic development | 190 | 507 | 1.61e-02 |
| GO:BP | GO:0090596 | sensory organ morphogenesis | 74 | 173 | 1.61e-02 |
| GO:BP | GO:0001657 | ureteric bud development | 36 | 72 | 1.61e-02 |
| GO:BP | GO:0055013 | cardiac muscle cell development | 36 | 72 | 1.61e-02 |
| GO:BP | GO:0030851 | granulocyte differentiation | 18 | 29 | 1.64e-02 |
| GO:BP | GO:0097106 | postsynaptic density organization | 18 | 29 | 1.64e-02 |
| GO:BP | GO:0086019 | cell-cell signaling involved in cardiac conduction | 18 | 29 | 1.64e-02 |
| GO:BP | GO:0021543 | pallium development | 60 | 135 | 1.64e-02 |
| GO:BP | GO:0001654 | eye development | 106 | 263 | 1.68e-02 |
| GO:BP | GO:0048640 | negative regulation of developmental growth | 41 | 85 | 1.70e-02 |
| GO:BP | GO:0030879 | mammary gland development | 46 | 98 | 1.71e-02 |
| GO:BP | GO:0048880 | sensory system development | 107 | 266 | 1.71e-02 |
| GO:BP | GO:0003007 | heart morphogenesis | 90 | 218 | 1.72e-02 |
| GO:BP | GO:0007548 | sex differentiation | 76 | 179 | 1.72e-02 |
| GO:BP | GO:0001838 | embryonic epithelial tube formation | 49 | 106 | 1.74e-02 |
| GO:BP | GO:0140747 | regulation of ncRNA transcription | 39 | 80 | 1.74e-02 |
| GO:BP | GO:0031214 | biomineral tissue development | 49 | 106 | 1.74e-02 |
| GO:BP | GO:0001659 | temperature homeostasis | 58 | 130 | 1.74e-02 |
| GO:BP | GO:0021987 | cerebral cortex development | 44 | 93 | 1.76e-02 |
| GO:BP | GO:0021872 | forebrain generation of neurons | 17 | 27 | 1.76e-02 |
| GO:BP | GO:0060038 | cardiac muscle cell proliferation | 24 | 43 | 1.76e-02 |
| GO:BP | GO:0060443 | mammary gland morphogenesis | 21 | 36 | 1.76e-02 |
| GO:BP | GO:0042246 | tissue regeneration | 29 | 55 | 1.76e-02 |
| GO:BP | GO:0000278 | mitotic cell cycle | 275 | 763 | 1.76e-02 |
| GO:BP | GO:0060416 | response to growth hormone | 17 | 27 | 1.76e-02 |
| GO:BP | GO:0034762 | regulation of transmembrane transport | 118 | 298 | 1.78e-02 |
| GO:BP | GO:0043068 | positive regulation of programmed cell death | 149 | 388 | 1.82e-02 |
| GO:BP | GO:0001649 | osteoblast differentiation | 74 | 174 | 1.83e-02 |
| GO:BP | GO:0150063 | visual system development | 106 | 264 | 1.85e-02 |
| GO:BP | GO:0009792 | embryo development ending in birth or egg hatching | 194 | 521 | 1.89e-02 |
| GO:BP | GO:0030500 | regulation of bone mineralization | 26 | 48 | 1.90e-02 |
| GO:BP | GO:0051960 | regulation of nervous system development | 132 | 339 | 1.90e-02 |
| GO:BP | GO:1904407 | positive regulation of nitric oxide metabolic process | 16 | 25 | 1.92e-02 |
| GO:BP | GO:0060603 | mammary gland duct morphogenesis | 16 | 25 | 1.92e-02 |
| GO:BP | GO:0033043 | regulation of organelle organization | 337 | 953 | 1.95e-02 |
| GO:BP | GO:0055006 | cardiac cell development | 38 | 78 | 1.95e-02 |
| GO:BP | GO:0003161 | cardiac conduction system development | 20 | 34 | 1.97e-02 |
| GO:BP | GO:0072163 | mesonephric epithelium development | 36 | 73 | 2.00e-02 |
| GO:BP | GO:0072164 | mesonephric tubule development | 36 | 73 | 2.00e-02 |
| GO:BP | GO:0046621 | negative regulation of organ growth | 15 | 23 | 2.10e-02 |
| GO:BP | GO:0048592 | eye morphogenesis | 49 | 107 | 2.10e-02 |
| GO:BP | GO:1903047 | mitotic cell cycle process | 236 | 648 | 2.13e-02 |
| GO:BP | GO:0097435 | supramolecular fiber organization | 231 | 633 | 2.13e-02 |
| GO:BP | GO:0070661 | leukocyte proliferation | 74 | 175 | 2.13e-02 |
| GO:BP | GO:0051179 | localization | 1218 | 3731 | 2.17e-02 |
| GO:BP | GO:0072077 | renal vesicle morphogenesis | 9 | 11 | 2.19e-02 |
| GO:BP | GO:0031345 | negative regulation of cell projection organization | 63 | 145 | 2.22e-02 |
| GO:BP | GO:1990874 | vascular associated smooth muscle cell proliferation | 27 | 51 | 2.29e-02 |
| GO:BP | GO:0019935 | cyclic-nucleotide-mediated signaling | 27 | 51 | 2.29e-02 |
| GO:BP | GO:0006955 | immune response | 308 | 867 | 2.29e-02 |
| GO:BP | GO:0045944 | positive regulation of transcription by RNA polymerase II | 310 | 874 | 2.45e-02 |
| GO:BP | GO:0019220 | regulation of phosphate metabolic process | 287 | 804 | 2.45e-02 |
| GO:BP | GO:0014841 | skeletal muscle satellite cell proliferation | 10 | 13 | 2.45e-02 |
| GO:BP | GO:0008610 | lipid biosynthetic process | 195 | 527 | 2.46e-02 |
| GO:BP | GO:0034103 | regulation of tissue remodeling | 24 | 44 | 2.50e-02 |
| GO:BP | GO:0086002 | cardiac muscle cell action potential involved in contraction | 24 | 44 | 2.50e-02 |
| GO:BP | GO:0060575 | intestinal epithelial cell differentiation | 12 | 17 | 2.50e-02 |
| GO:BP | GO:0099545 | trans-synaptic signaling by trans-synaptic complex | 6 | 6 | 2.53e-02 |
| GO:BP | GO:0030010 | establishment of cell polarity | 55 | 124 | 2.53e-02 |
| GO:BP | GO:0010616 | negative regulation of cardiac muscle adaptation | 6 | 6 | 2.53e-02 |
| GO:BP | GO:1903243 | negative regulation of cardiac muscle hypertrophy in response to stress | 6 | 6 | 2.53e-02 |
| GO:BP | GO:0003166 | bundle of His development | 6 | 6 | 2.53e-02 |
| GO:BP | GO:0009987 | cellular process | 3327 | 10686 | 2.58e-02 |
| GO:BP | GO:0051174 | regulation of phosphorus metabolic process | 287 | 805 | 2.60e-02 |
| GO:BP | GO:0048593 | camera-type eye morphogenesis | 41 | 87 | 2.61e-02 |
| GO:BP | GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 63 | 146 | 2.61e-02 |
| GO:BP | GO:1904705 | regulation of vascular associated smooth muscle cell proliferation | 26 | 49 | 2.61e-02 |
| GO:BP | GO:0060284 | regulation of cell development | 209 | 570 | 2.68e-02 |
| GO:BP | GO:0032944 | regulation of mononuclear cell proliferation | 53 | 119 | 2.70e-02 |
| GO:BP | GO:0055001 | muscle cell development | 69 | 163 | 2.85e-02 |
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | 192 | 520 | 2.89e-02 |
| GO:BP | GO:0120031 | plasma membrane bounded cell projection assembly | 164 | 437 | 2.93e-02 |
| GO:BP | GO:0045667 | regulation of osteoblast differentiation | 45 | 98 | 2.93e-02 |
| GO:BP | GO:0046622 | positive regulation of organ growth | 20 | 35 | 2.96e-02 |
| GO:BP | GO:0031099 | regeneration | 62 | 144 | 2.98e-02 |
| GO:BP | GO:1902117 | positive regulation of organelle assembly | 35 | 72 | 2.98e-02 |
| GO:BP | GO:0014743 | regulation of muscle hypertrophy | 25 | 47 | 3.02e-02 |
| GO:BP | GO:0042325 | regulation of phosphorylation | 246 | 683 | 3.07e-02 |
| GO:BP | GO:0070167 | regulation of biomineral tissue development | 31 | 62 | 3.13e-02 |
| GO:BP | GO:0110110 | positive regulation of animal organ morphogenesis | 16 | 26 | 3.13e-02 |
| GO:BP | GO:0010977 | negative regulation of neuron projection development | 49 | 109 | 3.13e-02 |
| GO:BP | GO:0002286 | T cell activation involved in immune response | 29 | 57 | 3.13e-02 |
| GO:BP | GO:0008284 | positive regulation of cell population proliferation | 220 | 605 | 3.14e-02 |
| GO:BP | GO:0008654 | phospholipid biosynthetic process | 88 | 217 | 3.14e-02 |
| GO:BP | GO:0030031 | cell projection assembly | 167 | 447 | 3.23e-02 |
| GO:BP | GO:0070372 | regulation of ERK1 and ERK2 cascade | 73 | 175 | 3.24e-02 |
| GO:BP | GO:0046632 | alpha-beta T cell differentiation | 34 | 70 | 3.45e-02 |
| GO:BP | GO:0007017 | microtubule-based process | 257 | 718 | 3.48e-02 |
| GO:BP | GO:0002027 | regulation of heart rate | 39 | 83 | 3.48e-02 |
| GO:BP | GO:0045429 | positive regulation of nitric oxide biosynthetic process | 15 | 24 | 3.50e-02 |
| GO:BP | GO:0086010 | membrane depolarization during action potential | 15 | 24 | 3.50e-02 |
| GO:BP | GO:0055117 | regulation of cardiac muscle contraction | 32 | 65 | 3.52e-02 |
| GO:BP | GO:0060291 | long-term synaptic potentiation | 32 | 65 | 3.52e-02 |
| GO:BP | GO:0006936 | muscle contraction | 101 | 255 | 3.54e-02 |
| GO:BP | GO:0030048 | actin filament-based movement | 48 | 107 | 3.57e-02 |
| GO:BP | GO:0046486 | glycerolipid metabolic process | 111 | 284 | 3.59e-02 |
| GO:BP | GO:0010628 | positive regulation of gene expression | 266 | 746 | 3.59e-02 |
| GO:BP | GO:0006937 | regulation of muscle contraction | 55 | 126 | 3.59e-02 |
| GO:BP | GO:0071840 | cellular component organization or biogenesis | 1603 | 4988 | 3.59e-02 |
| GO:BP | GO:0060491 | regulation of cell projection assembly | 67 | 159 | 3.59e-02 |
| GO:BP | GO:0048705 | skeletal system morphogenesis | 63 | 148 | 3.62e-02 |
| GO:BP | GO:0051130 | positive regulation of cellular component organization | 300 | 850 | 3.68e-02 |
| GO:BP | GO:0072001 | renal system development | 97 | 244 | 3.71e-02 |
| GO:BP | GO:2001222 | regulation of neuron migration | 21 | 38 | 3.71e-02 |
| GO:BP | GO:0120034 | positive regulation of plasma membrane bounded cell projection assembly | 40 | 86 | 3.72e-02 |
| GO:BP | GO:0003206 | cardiac chamber morphogenesis | 49 | 110 | 3.74e-02 |
| GO:BP | GO:0046651 | lymphocyte proliferation | 64 | 151 | 3.74e-02 |
| GO:BP | GO:0010644 | cell communication by electrical coupling | 18 | 31 | 3.76e-02 |
| GO:BP | GO:0050890 | cognition | 86 | 213 | 3.89e-02 |
| GO:BP | GO:0035051 | cardiocyte differentiation | 57 | 132 | 3.93e-02 |
| GO:BP | GO:0003093 | regulation of glomerular filtration | 7 | 8 | 3.98e-02 |
| GO:BP | GO:0014842 | regulation of skeletal muscle satellite cell proliferation | 7 | 8 | 3.98e-02 |
| GO:BP | GO:0001977 | renal system process involved in regulation of blood volume | 7 | 8 | 3.98e-02 |
| GO:BP | GO:0120032 | regulation of plasma membrane bounded cell projection assembly | 66 | 157 | 4.02e-02 |
| GO:BP | GO:0031668 | cellular response to extracellular stimulus | 88 | 219 | 4.04e-02 |
| GO:BP | GO:0065009 | regulation of molecular function | 445 | 1299 | 4.04e-02 |
| GO:BP | GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 514 | 1514 | 4.04e-02 |
| GO:BP | GO:0043367 | CD4-positive, alpha-beta T cell differentiation | 27 | 53 | 4.10e-02 |
| GO:BP | GO:0061448 | connective tissue development | 83 | 205 | 4.11e-02 |
| GO:BP | GO:0001932 | regulation of protein phosphorylation | 231 | 642 | 4.11e-02 |
| GO:BP | GO:0046649 | lymphocyte activation | 165 | 444 | 4.11e-02 |
| GO:BP | GO:0051049 | regulation of transport | 380 | 1098 | 4.11e-02 |
| GO:BP | GO:0003094 | glomerular filtration | 13 | 20 | 4.12e-02 |
| GO:BP | GO:0050776 | regulation of immune response | 176 | 477 | 4.19e-02 |
| GO:BP | GO:0048863 | stem cell differentiation | 78 | 191 | 4.19e-02 |
| GO:BP | GO:0000165 | MAPK cascade | 185 | 504 | 4.22e-02 |
| GO:BP | GO:0098609 | cell-cell adhesion | 205 | 564 | 4.22e-02 |
| GO:BP | GO:0002573 | myeloid leukocyte differentiation | 64 | 152 | 4.33e-02 |
| GO:BP | GO:0045216 | cell-cell junction organization | 64 | 152 | 4.33e-02 |
| GO:BP | GO:0051146 | striated muscle cell differentiation | 93 | 234 | 4.36e-02 |
| GO:BP | GO:0071880 | adenylate cyclase-activating adrenergic receptor signaling pathway | 12 | 18 | 4.46e-02 |
| GO:BP | GO:0031646 | positive regulation of nervous system process | 12 | 18 | 4.46e-02 |
| GO:BP | GO:0010171 | body morphogenesis | 22 | 41 | 4.48e-02 |
| GO:BP | GO:0043065 | positive regulation of apoptotic process | 143 | 380 | 4.54e-02 |
| GO:BP | GO:0007265 | Ras protein signal transduction | 43 | 95 | 4.57e-02 |
| GO:BP | GO:0010611 | regulation of cardiac muscle hypertrophy | 24 | 46 | 4.65e-02 |
| GO:BP | GO:0014857 | regulation of skeletal muscle cell proliferation | 8 | 10 | 4.68e-02 |
| GO:BP | GO:0031644 | regulation of nervous system process | 35 | 74 | 4.68e-02 |
| GO:BP | GO:1904646 | cellular response to amyloid-beta | 16 | 27 | 4.74e-02 |
| GO:BP | GO:0099084 | postsynaptic specialization organization | 19 | 34 | 4.74e-02 |
| GO:BP | GO:0098901 | regulation of cardiac muscle cell action potential | 16 | 27 | 4.74e-02 |
| GO:BP | GO:0072273 | metanephric nephron morphogenesis | 11 | 16 | 4.74e-02 |
| GO:BP | GO:0007043 | cell-cell junction assembly | 47 | 106 | 4.74e-02 |
| GO:BP | GO:1901021 | positive regulation of calcium ion transmembrane transporter activity | 16 | 27 | 4.74e-02 |
| GO:BP | GO:0031279 | regulation of cyclase activity | 16 | 27 | 4.74e-02 |
| GO:BP | GO:0002262 | myeloid cell homeostasis | 58 | 136 | 4.74e-02 |
| GO:BP | GO:0001817 | regulation of cytokine production | 162 | 437 | 4.76e-02 |
| GO:BP | GO:0002065 | columnar/cuboidal epithelial cell differentiation | 38 | 82 | 4.76e-02 |
| GO:BP | GO:0051283 | negative regulation of sequestering of calcium ion | 41 | 90 | 4.81e-02 |
| GO:BP | GO:1990778 | protein localization to cell periphery | 111 | 287 | 4.83e-02 |
| GO:BP | GO:0010889 | regulation of sequestering of triglyceride | 9 | 12 | 4.85e-02 |
| GO:BP | GO:0098792 | xenophagy | 9 | 12 | 4.85e-02 |
| GO:BP | GO:0016202 | regulation of striated muscle tissue development | 10 | 14 | 4.85e-02 |
| GO:BP | GO:0035721 | intraciliary retrograde transport | 10 | 14 | 4.85e-02 |
LR_int_restable %>%
filter(source=="KEGG") %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in LR neargenes intersected with RNA response genes") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | 54 | 134 | 1.79e-01 |
| KEGG | KEGG:00564 | Glycerophospholipid metabolism | 33 | 71 | 1.79e-01 |
| KEGG | KEGG:04911 | Insulin secretion | 29 | 62 | 1.79e-01 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | 50 | 124 | 1.79e-01 |
| KEGG | KEGG:04927 | Cortisol synthesis and secretion | 24 | 46 | 1.79e-01 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | 32 | 72 | 1.79e-01 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | 42 | 101 | 1.79e-01 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 34 | 78 | 1.79e-01 |
| KEGG | KEGG:04923 | Regulation of lipolysis in adipocytes | 20 | 41 | 1.79e-01 |
| KEGG | KEGG:03030 | DNA replication | 17 | 34 | 1.79e-01 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | 40 | 96 | 1.79e-01 |
| KEGG | KEGG:04360 | Axon guidance | 61 | 155 | 1.79e-01 |
| KEGG | KEGG:00230 | Purine metabolism | 41 | 93 | 1.79e-01 |
| KEGG | KEGG:04976 | Bile secretion | 21 | 41 | 1.79e-01 |
| KEGG | KEGG:04750 | Inflammatory mediator regulation of TRP channels | 34 | 72 | 1.79e-01 |
| KEGG | KEGG:05221 | Acute myeloid leukemia | 24 | 52 | 1.79e-01 |
| KEGG | KEGG:04148 | Efferocytosis | 50 | 120 | 1.79e-01 |
| KEGG | KEGG:04070 | Phosphatidylinositol signaling system | 39 | 83 | 1.79e-01 |
| KEGG | KEGG:05164 | Influenza A | 41 | 95 | 1.79e-01 |
| KEGG | KEGG:04068 | FoxO signaling pathway | 46 | 106 | 1.79e-01 |
| KEGG | KEGG:05032 | Morphine addiction | 25 | 54 | 1.79e-01 |
| KEGG | KEGG:04020 | Calcium signaling pathway | 63 | 161 | 1.79e-01 |
| KEGG | KEGG:04925 | Aldosterone synthesis and secretion | 33 | 75 | 1.79e-01 |
| KEGG | KEGG:05217 | Basal cell carcinoma | 23 | 48 | 1.79e-01 |
| KEGG | KEGG:04024 | cAMP signaling pathway | 59 | 147 | 1.79e-01 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | 64 | 162 | 1.79e-01 |
| KEGG | KEGG:05161 | Hepatitis B | 52 | 126 | 1.79e-01 |
| KEGG | KEGG:04611 | Platelet activation | 37 | 88 | 1.84e-01 |
| KEGG | KEGG:04924 | Renin secretion | 23 | 50 | 1.87e-01 |
| KEGG | KEGG:04668 | TNF signaling pathway | 35 | 83 | 1.93e-01 |
| KEGG | KEGG:00770 | Pantothenate and CoA biosynthesis | 9 | 15 | 1.96e-01 |
| KEGG | KEGG:04022 | cGMP-PKG signaling pathway | 51 | 129 | 1.97e-01 |
| KEGG | KEGG:04390 | Hippo signaling pathway | 51 | 129 | 1.97e-01 |
| KEGG | KEGG:04014 | Ras signaling pathway | 63 | 164 | 1.97e-01 |
| KEGG | KEGG:04970 | Salivary secretion | 24 | 54 | 2.18e-01 |
| KEGG | KEGG:04931 | Insulin resistance | 37 | 91 | 2.24e-01 |
| KEGG | KEGG:00000 | KEGG root term | 1718 | 5451 | 2.24e-01 |
| KEGG | KEGG:04727 | GABAergic synapse | 23 | 52 | 2.24e-01 |
| KEGG | KEGG:04659 | Th17 cell differentiation | 26 | 60 | 2.24e-01 |
| KEGG | KEGG:04110 | Cell cycle | 56 | 146 | 2.24e-01 |
| KEGG | KEGG:03410 | Base excision repair | 20 | 44 | 2.24e-01 |
| KEGG | KEGG:00562 | Inositol phosphate metabolism | 26 | 60 | 2.24e-01 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | 62 | 164 | 2.25e-01 |
| KEGG | KEGG:04814 | Motor proteins | 54 | 141 | 2.25e-01 |
| KEGG | KEGG:05142 | Chagas disease | 30 | 72 | 2.25e-01 |
| KEGG | KEGG:04730 | Long-term depression | 18 | 39 | 2.25e-01 |
| KEGG | KEGG:04913 | Ovarian steroidogenesis | 13 | 26 | 2.25e-01 |
| KEGG | KEGG:05152 | Tuberculosis | 40 | 101 | 2.41e-01 |
| KEGG | KEGG:04010 | MAPK signaling pathway | 84 | 231 | 2.41e-01 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | 60 | 160 | 2.46e-01 |
| KEGG | KEGG:04934 | Cushing syndrome | 46 | 119 | 2.46e-01 |
| KEGG | KEGG:00830 | Retinol metabolism | 8 | 14 | 2.46e-01 |
| KEGG | KEGG:04971 | Gastric acid secretion | 22 | 51 | 2.52e-01 |
| KEGG | KEGG:04725 | Cholinergic synapse | 33 | 82 | 2.52e-01 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | 54 | 143 | 2.52e-01 |
| KEGG | KEGG:03250 | Viral life cycle - HIV-1 | 23 | 54 | 2.52e-01 |
| KEGG | KEGG:04713 | Circadian entrainment | 28 | 68 | 2.52e-01 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | 30 | 74 | 2.59e-01 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | 50 | 132 | 2.59e-01 |
| KEGG | KEGG:04978 | Mineral absorption | 17 | 38 | 2.68e-01 |
| KEGG | KEGG:04210 | Apoptosis | 43 | 112 | 2.69e-01 |
| KEGG | KEGG:04310 | Wnt signaling pathway | 50 | 133 | 2.76e-01 |
| KEGG | KEGG:04380 | Osteoclast differentiation | 36 | 92 | 2.76e-01 |
| KEGG | KEGG:05216 | Thyroid cancer | 15 | 33 | 2.79e-01 |
| KEGG | KEGG:04064 | NF-kappa B signaling pathway | 25 | 61 | 2.89e-01 |
| KEGG | KEGG:05226 | Gastric cancer | 43 | 113 | 2.89e-01 |
| KEGG | KEGG:00220 | Arginine biosynthesis | 8 | 15 | 2.90e-01 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | 32 | 82 | 3.20e-01 |
| KEGG | KEGG:00910 | Nitrogen metabolism | 5 | 8 | 3.20e-01 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | 53 | 144 | 3.20e-01 |
| KEGG | KEGG:04724 | Glutamatergic synapse | 29 | 74 | 3.51e-01 |
| KEGG | KEGG:05213 | Endometrial cancer | 22 | 54 | 3.53e-01 |
| KEGG | KEGG:05200 | Pathways in cancer | 133 | 391 | 3.62e-01 |
| KEGG | KEGG:01524 | Platinum drug resistance | 24 | 60 | 3.62e-01 |
| KEGG | KEGG:04115 | p53 signaling pathway | 26 | 66 | 3.63e-01 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | 45 | 122 | 3.63e-01 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | 54 | 149 | 3.63e-01 |
| KEGG | KEGG:04211 | Longevity regulating pathway | 29 | 75 | 3.70e-01 |
| KEGG | KEGG:04960 | Aldosterone-regulated sodium reabsorption | 11 | 24 | 3.70e-01 |
| KEGG | KEGG:04950 | Maturity onset diabetes of the young | 3 | 4 | 3.80e-01 |
| KEGG | KEGG:00470 | D-Amino acid metabolism | 3 | 4 | 3.80e-01 |
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | 26 | 67 | 3.94e-01 |
| KEGG | KEGG:04061 | Viral protein interaction with cytokine and cytokine receptor | 9 | 19 | 3.94e-01 |
| KEGG | KEGG:00561 | Glycerolipid metabolism | 18 | 44 | 3.95e-01 |
| KEGG | KEGG:03320 | PPAR signaling pathway | 19 | 47 | 4.01e-01 |
| KEGG | KEGG:04936 | Alcoholic liver disease | 34 | 91 | 4.03e-01 |
| KEGG | KEGG:04728 | Dopaminergic synapse | 36 | 97 | 4.03e-01 |
| KEGG | KEGG:04918 | Thyroid hormone synthesis | 21 | 53 | 4.05e-01 |
| KEGG | KEGG:05218 | Melanoma | 22 | 56 | 4.08e-01 |
| KEGG | KEGG:04740 | Olfactory transduction | 11 | 25 | 4.17e-01 |
| KEGG | KEGG:04910 | Insulin signaling pathway | 41 | 113 | 4.17e-01 |
| KEGG | KEGG:04140 | Autophagy - animal | 53 | 149 | 4.17e-01 |
| KEGG | KEGG:04152 | AMPK signaling pathway | 37 | 101 | 4.17e-01 |
| KEGG | KEGG:04540 | Gap junction | 27 | 71 | 4.17e-01 |
| KEGG | KEGG:04630 | JAK-STAT signaling pathway | 31 | 83 | 4.17e-01 |
| KEGG | KEGG:04216 | Ferroptosis | 13 | 31 | 4.40e-01 |
| KEGG | KEGG:04972 | Pancreatic secretion | 22 | 57 | 4.40e-01 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | 33 | 90 | 4.43e-01 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | 32 | 87 | 4.43e-01 |
| KEGG | KEGG:05210 | Colorectal cancer | 30 | 81 | 4.43e-01 |
| KEGG | KEGG:04742 | Taste transduction | 9 | 20 | 4.43e-01 |
| KEGG | KEGG:04940 | Type I diabetes mellitus | 4 | 7 | 4.54e-01 |
| KEGG | KEGG:01040 | Biosynthesis of unsaturated fatty acids | 10 | 23 | 4.54e-01 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | 24 | 64 | 4.77e-01 |
| KEGG | KEGG:05215 | Prostate cancer | 30 | 82 | 4.77e-01 |
| KEGG | KEGG:04726 | Serotonergic synapse | 22 | 58 | 4.77e-01 |
| KEGG | KEGG:05030 | Cocaine addiction | 13 | 32 | 4.87e-01 |
| KEGG | KEGG:04930 | Type II diabetes mellitus | 14 | 35 | 4.87e-01 |
| KEGG | KEGG:05224 | Breast cancer | 40 | 113 | 4.87e-01 |
| KEGG | KEGG:04964 | Proximal tubule bicarbonate reclamation | 8 | 18 | 4.87e-01 |
| KEGG | KEGG:04966 | Collecting duct acid secretion | 8 | 18 | 4.87e-01 |
| KEGG | KEGG:03440 | Homologous recombination | 15 | 38 | 4.87e-01 |
| KEGG | KEGG:04072 | Phospholipase D signaling pathway | 38 | 107 | 4.88e-01 |
| KEGG | KEGG:04658 | Th1 and Th2 cell differentiation | 19 | 50 | 4.97e-01 |
| KEGG | KEGG:05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 24 | 65 | 5.00e-01 |
| KEGG | KEGG:04150 | mTOR signaling pathway | 45 | 129 | 5.02e-01 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | 37 | 105 | 5.24e-01 |
| KEGG | KEGG:05133 | Pertussis | 16 | 42 | 5.32e-01 |
| KEGG | KEGG:04916 | Melanogenesis | 27 | 75 | 5.32e-01 |
| KEGG | KEGG:04012 | ErbB signaling pathway | 27 | 75 | 5.32e-01 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | 32 | 90 | 5.32e-01 |
| KEGG | KEGG:00480 | Glutathione metabolism | 15 | 39 | 5.32e-01 |
| KEGG | KEGG:04917 | Prolactin signaling pathway | 20 | 54 | 5.33e-01 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | 49 | 143 | 5.42e-01 |
| KEGG | KEGG:04071 | Sphingolipid signaling pathway | 36 | 103 | 5.45e-01 |
| KEGG | KEGG:03430 | Mismatch repair | 9 | 22 | 5.64e-01 |
| KEGG | KEGG:05160 | Hepatitis C | 38 | 110 | 5.67e-01 |
| KEGG | KEGG:04392 | Hippo signaling pathway - multiple species | 10 | 25 | 5.67e-01 |
| KEGG | KEGG:04640 | Hematopoietic cell lineage | 11 | 28 | 5.67e-01 |
| KEGG | KEGG:03083 | Polycomb repressive complex | 25 | 70 | 5.67e-01 |
| KEGG | KEGG:04962 | Vasopressin-regulated water reabsorption | 14 | 37 | 5.71e-01 |
| KEGG | KEGG:04961 | Endocrine and other factor-regulated calcium reabsorption | 15 | 40 | 5.71e-01 |
| KEGG | KEGG:04530 | Tight junction | 44 | 129 | 5.73e-01 |
| KEGG | KEGG:05165 | Human papillomavirus infection | 83 | 252 | 5.92e-01 |
| KEGG | KEGG:04912 | GnRH signaling pathway | 26 | 74 | 6.01e-01 |
| KEGG | KEGG:04217 | Necroptosis | 34 | 99 | 6.14e-01 |
| KEGG | KEGG:04974 | Protein digestion and absorption | 20 | 56 | 6.14e-01 |
| KEGG | KEGG:00650 | Butanoate metabolism | 7 | 17 | 6.14e-01 |
| KEGG | KEGG:05321 | Inflammatory bowel disease | 8 | 20 | 6.14e-01 |
| KEGG | KEGG:00030 | Pentose phosphate pathway | 8 | 20 | 6.14e-01 |
| KEGG | KEGG:04136 | Autophagy - other | 11 | 29 | 6.18e-01 |
| KEGG | KEGG:05323 | Rheumatoid arthritis | 14 | 38 | 6.18e-01 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | 37 | 109 | 6.18e-01 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | 27 | 78 | 6.19e-01 |
| KEGG | KEGG:04514 | Cell adhesion molecules | 24 | 69 | 6.32e-01 |
| KEGG | KEGG:04060 | Cytokine-cytokine receptor interaction | 32 | 94 | 6.37e-01 |
| KEGG | KEGG:04620 | Toll-like receptor signaling pathway | 21 | 60 | 6.41e-01 |
| KEGG | KEGG:01522 | Endocrine resistance | 28 | 82 | 6.47e-01 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | 28 | 82 | 6.47e-01 |
| KEGG | KEGG:05162 | Measles | 29 | 85 | 6.47e-01 |
| KEGG | KEGG:00600 | Sphingolipid metabolism | 15 | 42 | 6.59e-01 |
| KEGG | KEGG:03450 | Non-homologous end-joining | 5 | 12 | 6.62e-01 |
| KEGG | KEGG:04744 | Phototransduction | 5 | 12 | 6.62e-01 |
| KEGG | KEGG:04218 | Cellular senescence | 45 | 136 | 6.62e-01 |
| KEGG | KEGG:05120 | Epithelial cell signaling in Helicobacter pylori infection | 19 | 55 | 6.83e-01 |
| KEGG | KEGG:00232 | Caffeine metabolism | 1 | 1 | 6.83e-01 |
| KEGG | KEGG:03260 | Virion - Human immunodeficiency virus | 1 | 1 | 6.83e-01 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | 26 | 77 | 6.87e-01 |
| KEGG | KEGG:05212 | Pancreatic cancer | 24 | 71 | 6.96e-01 |
| KEGG | KEGG:05211 | Renal cell carcinoma | 21 | 62 | 6.96e-01 |
| KEGG | KEGG:04621 | NOD-like receptor signaling pathway | 36 | 109 | 6.96e-01 |
| KEGG | KEGG:01232 | Nucleotide metabolism | 22 | 65 | 6.96e-01 |
| KEGG | KEGG:05146 | Amoebiasis | 21 | 62 | 6.96e-01 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | 28 | 84 | 6.96e-01 |
| KEGG | KEGG:04114 | Oocyte meiosis | 34 | 103 | 6.96e-01 |
| KEGG | KEGG:00270 | Cysteine and methionine metabolism | 13 | 37 | 6.96e-01 |
| KEGG | KEGG:04672 | Intestinal immune network for IgA production | 4 | 10 | 6.99e-01 |
| KEGG | KEGG:00250 | Alanine, aspartate and glutamate metabolism | 10 | 28 | 6.99e-01 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | 33 | 100 | 6.99e-01 |
| KEGG | KEGG:00592 | alpha-Linolenic acid metabolism | 4 | 10 | 6.99e-01 |
| KEGG | KEGG:00591 | Linoleic acid metabolism | 3 | 7 | 6.99e-01 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | 37 | 113 | 6.99e-01 |
| KEGG | KEGG:04213 | Longevity regulating pathway - multiple species | 17 | 50 | 6.99e-01 |
| KEGG | KEGG:05143 | African trypanosomiasis | 6 | 16 | 6.99e-01 |
| KEGG | KEGG:00534 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin | 7 | 19 | 6.99e-01 |
| KEGG | KEGG:05203 | Viral carcinogenesis | 46 | 142 | 6.99e-01 |
| KEGG | KEGG:00240 | Pyrimidine metabolism | 15 | 44 | 6.99e-01 |
| KEGG | KEGG:00310 | Lysine degradation | 19 | 56 | 6.99e-01 |
| KEGG | KEGG:04650 | Natural killer cell mediated cytotoxicity | 18 | 53 | 6.99e-01 |
| KEGG | KEGG:04080 | Neuroactive ligand-receptor interaction | 33 | 101 | 6.99e-01 |
| KEGG | KEGG:04977 | Vitamin digestion and absorption | 5 | 13 | 6.99e-01 |
| KEGG | KEGG:00515 | Mannose type O-glycan biosynthesis | 7 | 19 | 6.99e-01 |
| KEGG | KEGG:00410 | beta-Alanine metabolism | 8 | 22 | 6.99e-01 |
| KEGG | KEGG:05140 | Leishmaniasis | 13 | 38 | 7.05e-01 |
| KEGG | KEGG:04723 | Retrograde endocannabinoid signaling | 30 | 92 | 7.07e-01 |
| KEGG | KEGG:04215 | Apoptosis - multiple species | 10 | 29 | 7.18e-01 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | 79 | 250 | 7.18e-01 |
| KEGG | KEGG:04710 | Circadian rhythm | 10 | 29 | 7.18e-01 |
| KEGG | KEGG:04973 | Carbohydrate digestion and absorption | 10 | 29 | 7.18e-01 |
| KEGG | KEGG:04520 | Adherens junction | 27 | 83 | 7.18e-01 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | 26 | 80 | 7.24e-01 |
| KEGG | KEGG:04144 | Endocytosis | 68 | 216 | 7.52e-01 |
| KEGG | KEGG:00330 | Arginine and proline metabolism | 11 | 33 | 7.62e-01 |
| KEGG | KEGG:05214 | Glioma | 21 | 65 | 7.62e-01 |
| KEGG | KEGG:04721 | Synaptic vesicle cycle | 16 | 49 | 7.62e-01 |
| KEGG | KEGG:04137 | Mitophagy - animal | 30 | 94 | 7.62e-01 |
| KEGG | KEGG:04330 | Notch signaling pathway | 17 | 52 | 7.62e-01 |
| KEGG | KEGG:05132 | Salmonella infection | 63 | 201 | 7.64e-01 |
| KEGG | KEGG:00601 | Glycosphingolipid biosynthesis - lacto and neolacto series | 5 | 14 | 7.64e-01 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | 23 | 72 | 7.74e-01 |
| KEGG | KEGG:01100 | Metabolic pathways | 332 | 1077 | 7.74e-01 |
| KEGG | KEGG:02010 | ABC transporters | 8 | 24 | 7.81e-01 |
| KEGG | KEGG:05034 | Alcoholism | 32 | 102 | 7.81e-01 |
| KEGG | KEGG:04270 | Vascular smooth muscle contraction | 29 | 92 | 7.81e-01 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | 43 | 137 | 7.81e-01 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | 24 | 76 | 7.81e-01 |
| KEGG | KEGG:04260 | Cardiac muscle contraction | 20 | 63 | 7.81e-01 |
| KEGG | KEGG:00983 | Drug metabolism - other enzymes | 13 | 40 | 7.81e-01 |
| KEGG | KEGG:04929 | GnRH secretion | 16 | 50 | 7.81e-01 |
| KEGG | KEGG:05340 | Primary immunodeficiency | 3 | 8 | 7.81e-01 |
| KEGG | KEGG:03013 | Nucleocytoplasmic transport | 30 | 96 | 7.89e-01 |
| KEGG | KEGG:00440 | Phosphonate and phosphinate metabolism | 2 | 5 | 7.89e-01 |
| KEGG | KEGG:03265 | Virion - Ebolavirus and Lyssavirus | 2 | 5 | 7.89e-01 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | 34 | 109 | 7.89e-01 |
| KEGG | KEGG:04720 | Long-term potentiation | 16 | 51 | 8.16e-01 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | 42 | 136 | 8.16e-01 |
| KEGG | KEGG:03267 | Virion - Adenovirus | 1 | 2 | 8.26e-01 |
| KEGG | KEGG:00400 | Phenylalanine, tyrosine and tryptophan biosynthesis | 1 | 2 | 8.26e-01 |
| KEGG | KEGG:05135 | Yersinia infection | 33 | 107 | 8.26e-01 |
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | 39 | 127 | 8.30e-01 |
| KEGG | KEGG:05031 | Amphetamine addiction | 14 | 45 | 8.30e-01 |
| KEGG | KEGG:00062 | Fatty acid elongation | 7 | 22 | 8.30e-01 |
| KEGG | KEGG:00500 | Starch and sucrose metabolism | 7 | 22 | 8.30e-01 |
| KEGG | KEGG:04920 | Adipocytokine signaling pathway | 15 | 49 | 8.32e-01 |
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | 23 | 75 | 8.32e-01 |
| KEGG | KEGG:05145 | Toxoplasmosis | 22 | 72 | 8.32e-01 |
| KEGG | KEGG:04340 | Hedgehog signaling pathway | 15 | 49 | 8.32e-01 |
| KEGG | KEGG:00280 | Valine, leucine and isoleucine degradation | 13 | 42 | 8.32e-01 |
| KEGG | KEGG:05222 | Small cell lung cancer | 25 | 82 | 8.32e-01 |
| KEGG | KEGG:00061 | Fatty acid biosynthesis | 3 | 9 | 8.32e-01 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | 16 | 52 | 8.32e-01 |
| KEGG | KEGG:01230 | Biosynthesis of amino acids | 16 | 52 | 8.32e-01 |
| KEGG | KEGG:01210 | 2-Oxocarboxylic acid metabolism | 8 | 26 | 8.47e-01 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | 26 | 86 | 8.47e-01 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 49 | 162 | 8.47e-01 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | 51 | 169 | 8.53e-01 |
| KEGG | KEGG:00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 4 | 13 | 8.75e-01 |
| KEGG | KEGG:04371 | Apelin signaling pathway | 31 | 104 | 8.75e-01 |
| KEGG | KEGG:05144 | Malaria | 6 | 20 | 8.75e-01 |
| KEGG | KEGG:04370 | VEGF signaling pathway | 14 | 47 | 8.75e-01 |
| KEGG | KEGG:04145 | Phagosome | 25 | 84 | 8.75e-01 |
| KEGG | KEGG:05150 | Staphylococcus aureus infection | 4 | 13 | 8.75e-01 |
| KEGG | KEGG:03420 | Nucleotide excision repair | 16 | 54 | 8.79e-01 |
| KEGG | KEGG:04622 | RIG-I-like receptor signaling pathway | 13 | 44 | 8.82e-01 |
| KEGG | KEGG:00730 | Thiamine metabolism | 3 | 10 | 8.87e-01 |
| KEGG | KEGG:00920 | Sulfur metabolism | 3 | 10 | 8.87e-01 |
| KEGG | KEGG:05033 | Nicotine addiction | 3 | 10 | 8.87e-01 |
| KEGG | KEGG:05110 | Vibrio cholerae infection | 12 | 41 | 8.87e-01 |
| KEGG | KEGG:04614 | Renin-angiotensin system | 3 | 10 | 8.87e-01 |
| KEGG | KEGG:04130 | SNARE interactions in vesicular transport | 9 | 31 | 8.95e-01 |
| KEGG | KEGG:04932 | Non-alcoholic fatty liver disease | 37 | 126 | 9.03e-01 |
| KEGG | KEGG:00360 | Phenylalanine metabolism | 1 | 3 | 9.03e-01 |
| KEGG | KEGG:00290 | Valine, leucine and isoleucine biosynthesis | 1 | 3 | 9.03e-01 |
| KEGG | KEGG:04664 | Fc epsilon RI signaling pathway | 12 | 42 | 9.03e-01 |
| KEGG | KEGG:00565 | Ether lipid metabolism | 8 | 28 | 9.03e-01 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | 35 | 120 | 9.03e-01 |
| KEGG | KEGG:00450 | Selenocompound metabolism | 4 | 14 | 9.03e-01 |
| KEGG | KEGG:04146 | Peroxisome | 19 | 66 | 9.03e-01 |
| KEGG | KEGG:00900 | Terpenoid backbone biosynthesis | 6 | 21 | 9.03e-01 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | 30 | 104 | 9.12e-01 |
| KEGG | KEGG:01212 | Fatty acid metabolism | 13 | 46 | 9.12e-01 |
| KEGG | KEGG:00860 | Porphyrin metabolism | 5 | 18 | 9.12e-01 |
| KEGG | KEGG:03460 | Fanconi anemia pathway | 13 | 46 | 9.12e-01 |
| KEGG | KEGG:00350 | Tyrosine metabolism | 3 | 11 | 9.22e-01 |
| KEGG | KEGG:05416 | Viral myocarditis | 10 | 36 | 9.22e-01 |
| KEGG | KEGG:03082 | ATP-dependent chromatin remodeling | 26 | 91 | 9.22e-01 |
| KEGG | KEGG:03022 | Basal transcription factors | 9 | 33 | 9.36e-01 |
| KEGG | KEGG:00100 | Steroid biosynthesis | 4 | 15 | 9.36e-01 |
| KEGG | KEGG:04979 | Cholesterol metabolism | 9 | 33 | 9.36e-01 |
| KEGG | KEGG:04613 | Neutrophil extracellular trap formation | 25 | 89 | 9.47e-01 |
| KEGG | KEGG:00053 | Ascorbate and aldarate metabolism | 2 | 8 | 9.57e-01 |
| KEGG | KEGG:00563 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 6 | 23 | 9.57e-01 |
| KEGG | KEGG:04122 | Sulfur relay system | 2 | 8 | 9.57e-01 |
| KEGG | KEGG:00430 | Taurine and hypotaurine metabolism | 2 | 8 | 9.57e-01 |
| KEGG | KEGG:04657 | IL-17 signaling pathway | 15 | 55 | 9.57e-01 |
| KEGG | KEGG:00980 | Metabolism of xenobiotics by cytochrome P450 | 6 | 23 | 9.57e-01 |
| KEGG | KEGG:00524 | Neomycin, kanamycin and gentamicin biosynthesis | 1 | 4 | 9.57e-01 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | 20 | 73 | 9.57e-01 |
| KEGG | KEGG:00640 | Propanoate metabolism | 7 | 27 | 9.57e-01 |
| KEGG | KEGG:00785 | Lipoic acid metabolism | 4 | 16 | 9.57e-01 |
| KEGG | KEGG:00140 | Steroid hormone biosynthesis | 4 | 16 | 9.57e-01 |
| KEGG | KEGG:00620 | Pyruvate metabolism | 8 | 31 | 9.62e-01 |
| KEGG | KEGG:00532 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 5 | 20 | 9.62e-01 |
| KEGG | KEGG:04610 | Complement and coagulation cascades | 9 | 35 | 9.70e-01 |
| KEGG | KEGG:00512 | Mucin type O-glycan biosynthesis | 5 | 21 | 9.88e-01 |
| KEGG | KEGG:05131 | Shigellosis | 57 | 204 | 9.88e-01 |
| KEGG | KEGG:00052 | Galactose metabolism | 5 | 21 | 9.88e-01 |
| KEGG | KEGG:00380 | Tryptophan metabolism | 5 | 21 | 9.88e-01 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | 15 | 58 | 9.88e-01 |
| KEGG | KEGG:00590 | Arachidonic acid metabolism | 6 | 25 | 9.88e-01 |
| KEGG | KEGG:00630 | Glyoxylate and dicarboxylate metabolism | 6 | 25 | 9.88e-01 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | 93 | 364 | 1.00e+00 |
| KEGG | KEGG:05020 | Prion disease | 48 | 204 | 1.00e+00 |
| KEGG | KEGG:05016 | Huntington disease | 63 | 246 | 1.00e+00 |
| KEGG | KEGG:05012 | Parkinson disease | 49 | 211 | 1.00e+00 |
| KEGG | KEGG:05010 | Alzheimer disease | 72 | 296 | 1.00e+00 |
| KEGG | KEGG:04612 | Antigen processing and presentation | 5 | 26 | 1.00e+00 |
| KEGG | KEGG:00603 | Glycosphingolipid biosynthesis - globo and isoglobo series | 1 | 8 | 1.00e+00 |
| KEGG | KEGG:00604 | Glycosphingolipid biosynthesis - ganglio series | 2 | 12 | 1.00e+00 |
| KEGG | KEGG:04975 | Fat digestion and absorption | 4 | 18 | 1.00e+00 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | 76 | 291 | 1.00e+00 |
| KEGG | KEGG:00520 | Amino sugar and nucleotide sugar metabolism | 8 | 44 | 1.00e+00 |
| KEGG | KEGG:00760 | Nicotinate and nicotinamide metabolism | 6 | 28 | 1.00e+00 |
| KEGG | KEGG:00790 | Folate biosynthesis | 3 | 18 | 1.00e+00 |
| KEGG | KEGG:00970 | Aminoacyl-tRNA biosynthesis | 7 | 42 | 1.00e+00 |
| KEGG | KEGG:00982 | Drug metabolism - cytochrome P450 | 3 | 16 | 1.00e+00 |
| KEGG | KEGG:01200 | Carbon metabolism | 22 | 88 | 1.00e+00 |
| KEGG | KEGG:01240 | Biosynthesis of cofactors | 28 | 109 | 1.00e+00 |
| KEGG | KEGG:01250 | Biosynthesis of nucleotide sugars | 5 | 34 | 1.00e+00 |
| KEGG | KEGG:01523 | Antifolate resistance | 4 | 22 | 1.00e+00 |
| KEGG | KEGG:00740 | Riboflavin metabolism | 1 | 6 | 1.00e+00 |
| KEGG | KEGG:00750 | Vitamin B6 metabolism | 1 | 5 | 1.00e+00 |
| KEGG | KEGG:00513 | Various types of N-glycan biosynthesis | 5 | 37 | 1.00e+00 |
| KEGG | KEGG:03008 | Ribosome biogenesis in eukaryotes | 10 | 65 | 1.00e+00 |
| KEGG | KEGG:05415 | Diabetic cardiomyopathy | 40 | 158 | 1.00e+00 |
| KEGG | KEGG:05322 | Systemic lupus erythematosus | 5 | 44 | 1.00e+00 |
| KEGG | KEGG:04510 | Focal adhesion | 34 | 169 | 1.00e+00 |
| KEGG | KEGG:04512 | ECM-receptor interaction | 11 | 66 | 1.00e+00 |
| KEGG | KEGG:05219 | Bladder cancer | 6 | 35 | 1.00e+00 |
| KEGG | KEGG:05208 | Chemical carcinogenesis - reactive oxygen species | 40 | 173 | 1.00e+00 |
| KEGG | KEGG:00010 | Glycolysis / Gluconeogenesis | 9 | 41 | 1.00e+00 |
| KEGG | KEGG:05204 | Chemical carcinogenesis - DNA adducts | 4 | 20 | 1.00e+00 |
| KEGG | KEGG:00020 | Citrate cycle (TCA cycle) | 6 | 26 | 1.00e+00 |
| KEGG | KEGG:00040 | Pentose and glucuronate interconversions | 1 | 11 | 1.00e+00 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | 30 | 149 | 1.00e+00 |
| KEGG | KEGG:00051 | Fructose and mannose metabolism | 3 | 26 | 1.00e+00 |
| KEGG | KEGG:05168 | Herpes simplex virus 1 infection | 78 | 388 | 1.00e+00 |
| KEGG | KEGG:00071 | Fatty acid degradation | 7 | 31 | 1.00e+00 |
| KEGG | KEGG:00120 | Primary bile acid biosynthesis | 1 | 11 | 1.00e+00 |
| KEGG | KEGG:00190 | Oxidative phosphorylation | 17 | 99 | 1.00e+00 |
| KEGG | KEGG:00260 | Glycine, serine and threonine metabolism | 5 | 26 | 1.00e+00 |
| KEGG | KEGG:05134 | Legionellosis | 7 | 34 | 1.00e+00 |
| KEGG | KEGG:00340 | Histidine metabolism | 2 | 10 | 1.00e+00 |
| KEGG | KEGG:00510 | N-Glycan biosynthesis | 8 | 49 | 1.00e+00 |
| KEGG | KEGG:00511 | Other glycan degradation | 2 | 14 | 1.00e+00 |
| KEGG | KEGG:00514 | Other types of O-glycan biosynthesis | 8 | 35 | 1.00e+00 |
| KEGG | KEGG:03010 | Ribosome | 15 | 121 | 1.00e+00 |
| KEGG | KEGG:00670 | One carbon pool by folate | 3 | 18 | 1.00e+00 |
| KEGG | KEGG:03018 | RNA degradation | 17 | 67 | 1.00e+00 |
| KEGG | KEGG:03015 | mRNA surveillance pathway | 17 | 80 | 1.00e+00 |
| KEGG | KEGG:04714 | Thermogenesis | 45 | 185 | 1.00e+00 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | 27 | 149 | 1.00e+00 |
| KEGG | KEGG:04142 | Lysosome | 26 | 109 | 1.00e+00 |
| KEGG | KEGG:03266 | Virion - Herpesvirus | 1 | 6 | 1.00e+00 |
| KEGG | KEGG:03060 | Protein export | 5 | 28 | 1.00e+00 |
| KEGG | KEGG:04623 | Cytosolic DNA-sensing pathway | 10 | 46 | 1.00e+00 |
| KEGG | KEGG:03050 | Proteasome | 6 | 40 | 1.00e+00 |
| KEGG | KEGG:03040 | Spliceosome | 14 | 124 | 1.00e+00 |
| KEGG | KEGG:03020 | RNA polymerase | 6 | 33 | 1.00e+00 |
# intersect(unique(Resp_RNA$ENTREZID), unique(NR_peak_list_20k$ENTREZID)))
LR_int_restable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
slice_head(n=10) %>%
mutate(log10_p=(-log(p_value, base=10))) %>%
ggplot(., aes(x=log10_p, y=reorder(term_name, log10_p)))+
geom_col(fill="#00BFC4")+
theme_bw()+
ylab("")+
xlab(paste0("-log10 p-value"))+
guides(fill="none")+
theme(axis.text.y = element_text(color="black"))+
ggtitle("Intersection LR")
#### NR
NR_int_resgenes <- gost(query = int_NR_n_RNAresp,
organism = "hsapiens",
significant = FALSE,
ordered_query = FALSE,
domain_scope = "custom",
measure_underrepresentation = FALSE,
evcodes = FALSE,
user_threshold = 0.05,
correction_method = c("fdr"),
custom_bg = background_df$ENTREZID,
sources=c("GO:BP","KEGG"))
saveRDS(NR_int_resgenes,"data/GO_KEGG_analysis/NR_int_resgenes.RDS")
NR_int_restable <- NR_int_resgenes$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
NR_int_restable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in NR neargenes intersected with RNA response genes" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0007049 | cell cycle | 749 | 1436 | 3.20e-07 |
| GO:BP | GO:0007059 | chromosome segregation | 214 | 351 | 4.26e-07 |
| GO:BP | GO:0022402 | cell cycle process | 548 | 1024 | 4.67e-07 |
| GO:BP | GO:0050794 | regulation of cellular process | 3320 | 7153 | 5.99e-07 |
| GO:BP | GO:0048523 | negative regulation of cellular process | 1709 | 3550 | 6.52e-06 |
| GO:BP | GO:0050789 | regulation of biological process | 3463 | 7516 | 1.01e-05 |
| GO:BP | GO:0065007 | biological regulation | 3558 | 7734 | 1.01e-05 |
| GO:BP | GO:0000280 | nuclear division | 198 | 335 | 1.77e-05 |
| GO:BP | GO:0051716 | cellular response to stimulus | 2192 | 4640 | 1.77e-05 |
| GO:BP | GO:0006974 | DNA damage response | 400 | 745 | 3.39e-05 |
| GO:BP | GO:0048519 | negative regulation of biological process | 1793 | 3764 | 5.18e-05 |
| GO:BP | GO:0098813 | nuclear chromosome segregation | 155 | 256 | 5.75e-05 |
| GO:BP | GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 595 | 1157 | 5.77e-05 |
| GO:BP | GO:0000278 | mitotic cell cycle | 406 | 763 | 7.44e-05 |
| GO:BP | GO:1903047 | mitotic cell cycle process | 349 | 648 | 1.19e-04 |
| GO:BP | GO:0000070 | mitotic sister chromatid segregation | 108 | 170 | 1.49e-04 |
| GO:BP | GO:0000226 | microtubule cytoskeleton organization | 285 | 520 | 2.02e-04 |
| GO:BP | GO:0000819 | sister chromatid segregation | 127 | 207 | 2.12e-04 |
| GO:BP | GO:0061982 | meiosis I cell cycle process | 57 | 79 | 2.24e-04 |
| GO:BP | GO:0051253 | negative regulation of RNA metabolic process | 547 | 1067 | 2.30e-04 |
| GO:BP | GO:0051276 | chromosome organization | 277 | 506 | 2.60e-04 |
| GO:BP | GO:0010564 | regulation of cell cycle process | 321 | 596 | 2.60e-04 |
| GO:BP | GO:1902850 | microtubule cytoskeleton organization involved in mitosis | 94 | 146 | 2.60e-04 |
| GO:BP | GO:0033554 | cellular response to stress | 717 | 1433 | 3.22e-04 |
| GO:BP | GO:0007051 | spindle organization | 110 | 177 | 3.75e-04 |
| GO:BP | GO:0051726 | regulation of cell cycle | 457 | 885 | 6.27e-04 |
| GO:BP | GO:0050896 | response to stimulus | 2496 | 5379 | 6.31e-04 |
| GO:BP | GO:0048285 | organelle fission | 211 | 377 | 6.31e-04 |
| GO:BP | GO:0019219 | regulation of nucleobase-containing compound metabolic process | 1384 | 2895 | 6.31e-04 |
| GO:BP | GO:0140013 | meiotic nuclear division | 78 | 119 | 6.51e-04 |
| GO:BP | GO:0045892 | negative regulation of DNA-templated transcription | 494 | 965 | 6.88e-04 |
| GO:BP | GO:1903046 | meiotic cell cycle process | 86 | 134 | 6.88e-04 |
| GO:BP | GO:0007127 | meiosis I | 52 | 73 | 7.96e-04 |
| GO:BP | GO:0006357 | regulation of transcription by RNA polymerase II | 875 | 1787 | 1.08e-03 |
| GO:BP | GO:1902679 | negative regulation of RNA biosynthetic process | 496 | 973 | 1.11e-03 |
| GO:BP | GO:0051252 | regulation of RNA metabolic process | 1275 | 2663 | 1.11e-03 |
| GO:BP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 368 | 704 | 1.12e-03 |
| GO:BP | GO:0140014 | mitotic nuclear division | 141 | 241 | 1.12e-03 |
| GO:BP | GO:0021537 | telencephalon development | 117 | 195 | 1.33e-03 |
| GO:BP | GO:0051301 | cell division | 289 | 541 | 1.33e-03 |
| GO:BP | GO:0090304 | nucleic acid metabolic process | 1774 | 3777 | 1.88e-03 |
| GO:BP | GO:0006355 | regulation of DNA-templated transcription | 1156 | 2410 | 2.17e-03 |
| GO:BP | GO:0006366 | transcription by RNA polymerase II | 913 | 1879 | 2.28e-03 |
| GO:BP | GO:0007010 | cytoskeleton organization | 574 | 1146 | 2.28e-03 |
| GO:BP | GO:0006260 | DNA replication | 142 | 246 | 2.36e-03 |
| GO:BP | GO:0007017 | microtubule-based process | 372 | 718 | 2.41e-03 |
| GO:BP | GO:0030900 | forebrain development | 155 | 272 | 2.41e-03 |
| GO:BP | GO:2001141 | regulation of RNA biosynthetic process | 1160 | 2422 | 2.56e-03 |
| GO:BP | GO:0040007 | growth | 361 | 697 | 3.12e-03 |
| GO:BP | GO:0031323 | regulation of cellular metabolic process | 1974 | 4233 | 3.12e-03 |
| GO:BP | GO:0010558 | negative regulation of macromolecule biosynthetic process | 777 | 1588 | 3.27e-03 |
| GO:BP | GO:0006351 | DNA-templated transcription | 1198 | 2510 | 3.50e-03 |
| GO:BP | GO:0009890 | negative regulation of biosynthetic process | 797 | 1635 | 4.54e-03 |
| GO:BP | GO:0032774 | RNA biosynthetic process | 1207 | 2533 | 4.54e-03 |
| GO:BP | GO:0006281 | DNA repair | 269 | 508 | 4.84e-03 |
| GO:BP | GO:0051321 | meiotic cell cycle | 107 | 181 | 5.94e-03 |
| GO:BP | GO:0031327 | negative regulation of cellular biosynthetic process | 790 | 1624 | 6.69e-03 |
| GO:BP | GO:0033043 | regulation of organelle organization | 478 | 953 | 8.28e-03 |
| GO:BP | GO:0048589 | developmental growth | 264 | 501 | 8.28e-03 |
| GO:BP | GO:0045786 | negative regulation of cell cycle | 177 | 322 | 8.28e-03 |
| GO:BP | GO:0007093 | mitotic cell cycle checkpoint signaling | 81 | 132 | 8.28e-03 |
| GO:BP | GO:0048522 | positive regulation of cellular process | 1842 | 3954 | 8.36e-03 |
| GO:BP | GO:0007052 | mitotic spindle organization | 73 | 117 | 8.52e-03 |
| GO:BP | GO:0048518 | positive regulation of biological process | 1996 | 4301 | 9.30e-03 |
| GO:BP | GO:0008283 | cell population proliferation | 641 | 1306 | 1.04e-02 |
| GO:BP | GO:0034654 | nucleobase-containing compound biosynthetic process | 1351 | 2867 | 1.31e-02 |
| GO:BP | GO:0031324 | negative regulation of cellular metabolic process | 928 | 1934 | 1.31e-02 |
| GO:BP | GO:0007154 | cell communication | 1851 | 3983 | 1.42e-02 |
| GO:BP | GO:1990830 | cellular response to leukemia inhibitory factor | 54 | 83 | 1.50e-02 |
| GO:BP | GO:1990823 | response to leukemia inhibitory factor | 55 | 85 | 1.59e-02 |
| GO:BP | GO:0000075 | cell cycle checkpoint signaling | 104 | 179 | 1.60e-02 |
| GO:BP | GO:0019222 | regulation of metabolic process | 2126 | 4603 | 1.62e-02 |
| GO:BP | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore | 18 | 21 | 1.63e-02 |
| GO:BP | GO:0018130 | heterocycle biosynthetic process | 1376 | 2927 | 1.63e-02 |
| GO:BP | GO:0007165 | signal transduction | 1683 | 3611 | 1.63e-02 |
| GO:BP | GO:0010605 | negative regulation of macromolecule metabolic process | 934 | 1951 | 1.63e-02 |
| GO:BP | GO:0006261 | DNA-templated DNA replication | 88 | 148 | 1.63e-02 |
| GO:BP | GO:0019438 | aromatic compound biosynthetic process | 1376 | 2928 | 1.70e-02 |
| GO:BP | GO:0060255 | regulation of macromolecule metabolic process | 1959 | 4231 | 1.83e-02 |
| GO:BP | GO:0071496 | cellular response to external stimulus | 148 | 268 | 1.89e-02 |
| GO:BP | GO:0060322 | head development | 279 | 539 | 1.95e-02 |
| GO:BP | GO:0051303 | establishment of chromosome localization | 62 | 99 | 2.05e-02 |
| GO:BP | GO:0010468 | regulation of gene expression | 1577 | 3379 | 2.07e-02 |
| GO:BP | GO:0051983 | regulation of chromosome segregation | 73 | 120 | 2.07e-02 |
| GO:BP | GO:0010639 | negative regulation of organelle organization | 158 | 289 | 2.09e-02 |
| GO:BP | GO:0050000 | chromosome localization | 66 | 107 | 2.33e-02 |
| GO:BP | GO:0045444 | fat cell differentiation | 103 | 179 | 2.33e-02 |
| GO:BP | GO:1902894 | negative regulation of miRNA transcription | 19 | 23 | 2.33e-02 |
| GO:BP | GO:0051225 | spindle assembly | 68 | 111 | 2.42e-02 |
| GO:BP | GO:0051310 | metaphase chromosome alignment | 59 | 94 | 2.46e-02 |
| GO:BP | GO:0006259 | DNA metabolic process | 416 | 832 | 2.48e-02 |
| GO:BP | GO:0023052 | signaling | 1816 | 3918 | 2.59e-02 |
| GO:BP | GO:0009892 | negative regulation of metabolic process | 998 | 2100 | 2.71e-02 |
| GO:BP | GO:0035556 | intracellular signal transduction | 930 | 1951 | 2.74e-02 |
| GO:BP | GO:1901362 | organic cyclic compound biosynthetic process | 1416 | 3026 | 2.74e-02 |
| GO:BP | GO:0051172 | negative regulation of nitrogen compound metabolic process | 785 | 1633 | 2.74e-02 |
| GO:BP | GO:2001251 | negative regulation of chromosome organization | 54 | 85 | 2.74e-02 |
| GO:BP | GO:0010556 | regulation of macromolecule biosynthetic process | 1622 | 3486 | 2.78e-02 |
| GO:BP | GO:2000629 | negative regulation of miRNA metabolic process | 20 | 25 | 3.17e-02 |
| GO:BP | GO:0009262 | deoxyribonucleotide metabolic process | 26 | 35 | 3.22e-02 |
| GO:BP | GO:0019692 | deoxyribose phosphate metabolic process | 26 | 35 | 3.22e-02 |
| GO:BP | GO:0007275 | multicellular organism development | 1479 | 3170 | 3.28e-02 |
| GO:BP | GO:0051128 | regulation of cellular component organization | 888 | 1862 | 3.42e-02 |
| GO:BP | GO:0009888 | tissue development | 653 | 1348 | 3.42e-02 |
| GO:BP | GO:0007420 | brain development | 257 | 498 | 3.49e-02 |
| GO:BP | GO:0031326 | regulation of cellular biosynthetic process | 1657 | 3569 | 3.53e-02 |
| GO:BP | GO:0072359 | circulatory system development | 429 | 864 | 3.54e-02 |
| GO:BP | GO:0009889 | regulation of biosynthetic process | 1668 | 3595 | 3.79e-02 |
| GO:BP | GO:0051239 | regulation of multicellular organismal process | 915 | 1924 | 4.01e-02 |
| GO:BP | GO:0086004 | regulation of cardiac muscle cell contraction | 24 | 32 | 4.01e-02 |
| GO:BP | GO:0003338 | metanephros morphogenesis | 16 | 19 | 4.17e-02 |
| GO:BP | GO:0090068 | positive regulation of cell cycle process | 114 | 204 | 4.20e-02 |
| GO:BP | GO:0061351 | neural precursor cell proliferation | 71 | 119 | 4.26e-02 |
| GO:BP | GO:0051299 | centrosome separation | 12 | 13 | 4.26e-02 |
| GO:BP | GO:0007098 | centrosome cycle | 72 | 121 | 4.26e-02 |
| GO:BP | GO:0006996 | organelle organization | 1317 | 2815 | 4.26e-02 |
| GO:BP | GO:0060562 | epithelial tube morphogenesis | 142 | 261 | 4.26e-02 |
| GO:BP | GO:0007389 | pattern specification process | 154 | 286 | 4.64e-02 |
| GO:BP | GO:0006139 | nucleobase-containing compound metabolic process | 1929 | 4185 | 4.66e-02 |
| GO:BP | GO:0009394 | 2’-deoxyribonucleotide metabolic process | 25 | 34 | 4.66e-02 |
| GO:BP | GO:0007417 | central nervous system development | 348 | 694 | 4.75e-02 |
| GO:BP | GO:0042127 | regulation of cell population proliferation | 526 | 1077 | 4.75e-02 |
| GO:BP | GO:0007507 | heart development | 256 | 499 | 4.86e-02 |
| GO:BP | GO:0045930 | negative regulation of mitotic cell cycle | 111 | 199 | 4.93e-02 |
NR_int_restable %>%
filter(source=="KEGG") %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in NR neargenes intersected with RNA response genes") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:04115 | p53 signaling pathway | 44 | 66 | 5.84e-02 |
| KEGG | KEGG:04110 | Cell cycle | 85 | 146 | 6.34e-02 |
| KEGG | KEGG:05217 | Basal cell carcinoma | 32 | 48 | 1.12e-01 |
| KEGG | KEGG:00230 | Purine metabolism | 56 | 93 | 1.12e-01 |
| KEGG | KEGG:03410 | Base excision repair | 29 | 44 | 1.95e-01 |
| KEGG | KEGG:04070 | Phosphatidylinositol signaling system | 48 | 83 | 3.92e-01 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | 88 | 164 | 3.92e-01 |
| KEGG | KEGG:01524 | Platinum drug resistance | 36 | 60 | 3.99e-01 |
| KEGG | KEGG:03030 | DNA replication | 22 | 34 | 4.50e-01 |
| KEGG | KEGG:05224 | Breast cancer | 62 | 113 | 4.50e-01 |
| KEGG | KEGG:05221 | Acute myeloid leukemia | 31 | 52 | 5.38e-01 |
| KEGG | KEGG:03430 | Mismatch repair | 15 | 22 | 5.66e-01 |
| KEGG | KEGG:05226 | Gastric cancer | 60 | 113 | 7.66e-01 |
| KEGG | KEGG:00562 | Inositol phosphate metabolism | 34 | 60 | 7.66e-01 |
| KEGG | KEGG:03083 | Polycomb repressive complex | 39 | 70 | 7.66e-01 |
| KEGG | KEGG:03460 | Fanconi anemia pathway | 26 | 46 | 8.05e-01 |
| KEGG | KEGG:04978 | Mineral absorption | 22 | 38 | 8.05e-01 |
| KEGG | KEGG:00564 | Glycerophospholipid metabolism | 39 | 71 | 8.05e-01 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | 53 | 101 | 8.05e-01 |
| KEGG | KEGG:05034 | Alcoholism | 54 | 102 | 8.05e-01 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | 63 | 122 | 8.05e-01 |
| KEGG | KEGG:03250 | Viral life cycle - HIV-1 | 30 | 54 | 8.05e-01 |
| KEGG | KEGG:03440 | Homologous recombination | 22 | 38 | 8.05e-01 |
| KEGG | KEGG:04966 | Collecting duct acid secretion | 12 | 18 | 8.05e-01 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | 44 | 82 | 8.05e-01 |
| KEGG | KEGG:04814 | Motor proteins | 72 | 141 | 8.05e-01 |
| KEGG | KEGG:04068 | FoxO signaling pathway | 55 | 106 | 8.06e-01 |
| KEGG | KEGG:04934 | Cushing syndrome | 61 | 119 | 8.07e-01 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | 34 | 64 | 8.07e-01 |
| KEGG | KEGG:05216 | Thyroid cancer | 19 | 33 | 8.07e-01 |
| KEGG | KEGG:04217 | Necroptosis | 51 | 99 | 8.07e-01 |
| KEGG | KEGG:00910 | Nitrogen metabolism | 6 | 8 | 8.07e-01 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | 38 | 72 | 8.07e-01 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | 72 | 144 | 8.07e-01 |
| KEGG | KEGG:04216 | Ferroptosis | 18 | 31 | 8.07e-01 |
| KEGG | KEGG:04148 | Efferocytosis | 61 | 120 | 8.07e-01 |
| KEGG | KEGG:04146 | Peroxisome | 35 | 66 | 8.07e-01 |
| KEGG | KEGG:04750 | Inflammatory mediator regulation of TRP channels | 38 | 72 | 8.07e-01 |
| KEGG | KEGG:04923 | Regulation of lipolysis in adipocytes | 23 | 41 | 8.07e-01 |
| KEGG | KEGG:05218 | Melanoma | 30 | 56 | 8.13e-01 |
| KEGG | KEGG:03420 | Nucleotide excision repair | 29 | 54 | 8.13e-01 |
| KEGG | KEGG:05213 | Endometrial cancer | 29 | 54 | 8.13e-01 |
| KEGG | KEGG:05161 | Hepatitis B | 63 | 126 | 8.15e-01 |
| KEGG | KEGG:00830 | Retinol metabolism | 9 | 14 | 8.15e-01 |
| KEGG | KEGG:04927 | Cortisol synthesis and secretion | 25 | 46 | 8.15e-01 |
| KEGG | KEGG:04390 | Hippo signaling pathway | 64 | 129 | 8.82e-01 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | 67 | 137 | 9.57e-01 |
| KEGG | KEGG:00480 | Glutathione metabolism | 21 | 39 | 9.57e-01 |
| KEGG | KEGG:05210 | Colorectal cancer | 41 | 81 | 9.57e-01 |
| KEGG | KEGG:04668 | TNF signaling pathway | 42 | 83 | 9.57e-01 |
| KEGG | KEGG:04940 | Type I diabetes mellitus | 5 | 7 | 9.57e-01 |
| KEGG | KEGG:04976 | Bile secretion | 22 | 41 | 9.57e-01 |
| KEGG | KEGG:05032 | Morphine addiction | 28 | 54 | 9.80e-01 |
| KEGG | KEGG:00770 | Pantothenate and CoA biosynthesis | 9 | 15 | 9.80e-01 |
| KEGG | KEGG:00515 | Mannose type O-glycan biosynthesis | 11 | 19 | 9.80e-01 |
| KEGG | KEGG:00220 | Arginine biosynthesis | 9 | 15 | 9.80e-01 |
| KEGG | KEGG:04210 | Apoptosis | 55 | 112 | 9.80e-01 |
| KEGG | KEGG:05203 | Viral carcinogenesis | 69 | 142 | 9.80e-01 |
| KEGG | KEGG:03060 | Protein export | 7 | 28 | 1.00e+00 |
| KEGG | KEGG:00330 | Arginine and proline metabolism | 16 | 33 | 1.00e+00 |
| KEGG | KEGG:00591 | Linoleic acid metabolism | 3 | 7 | 1.00e+00 |
| KEGG | KEGG:04014 | Ras signaling pathway | 71 | 164 | 1.00e+00 |
| KEGG | KEGG:00340 | Histidine metabolism | 4 | 10 | 1.00e+00 |
| KEGG | KEGG:01523 | Antifolate resistance | 9 | 22 | 1.00e+00 |
| KEGG | KEGG:00524 | Neomycin, kanamycin and gentamicin biosynthesis | 1 | 4 | 1.00e+00 |
| KEGG | KEGG:00350 | Tyrosine metabolism | 6 | 11 | 1.00e+00 |
| KEGG | KEGG:00514 | Other types of O-glycan biosynthesis | 8 | 35 | 1.00e+00 |
| KEGG | KEGG:00513 | Various types of N-glycan biosynthesis | 6 | 37 | 1.00e+00 |
| KEGG | KEGG:04012 | ErbB signaling pathway | 34 | 75 | 1.00e+00 |
| KEGG | KEGG:00532 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 7 | 20 | 1.00e+00 |
| KEGG | KEGG:03008 | Ribosome biogenesis in eukaryotes | 28 | 65 | 1.00e+00 |
| KEGG | KEGG:00650 | Butanoate metabolism | 7 | 17 | 1.00e+00 |
| KEGG | KEGG:04010 | MAPK signaling pathway | 105 | 231 | 1.00e+00 |
| KEGG | KEGG:00512 | Mucin type O-glycan biosynthesis | 5 | 21 | 1.00e+00 |
| KEGG | KEGG:00860 | Porphyrin metabolism | 9 | 18 | 1.00e+00 |
| KEGG | KEGG:02010 | ABC transporters | 12 | 24 | 1.00e+00 |
| KEGG | KEGG:00520 | Amino sugar and nucleotide sugar metabolism | 14 | 44 | 1.00e+00 |
| KEGG | KEGG:00604 | Glycosphingolipid biosynthesis - ganglio series | 3 | 12 | 1.00e+00 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | 72 | 162 | 1.00e+00 |
| KEGG | KEGG:00290 | Valine, leucine and isoleucine biosynthesis | 1 | 3 | 1.00e+00 |
| KEGG | KEGG:00601 | Glycosphingolipid biosynthesis - lacto and neolacto series | 6 | 14 | 1.00e+00 |
| KEGG | KEGG:01250 | Biosynthesis of nucleotide sugars | 10 | 34 | 1.00e+00 |
| KEGG | KEGG:01240 | Biosynthesis of cofactors | 45 | 109 | 1.00e+00 |
| KEGG | KEGG:04024 | cAMP signaling pathway | 67 | 147 | 1.00e+00 |
| KEGG | KEGG:00563 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 10 | 23 | 1.00e+00 |
| KEGG | KEGG:00603 | Glycosphingolipid biosynthesis - globo and isoglobo series | 1 | 8 | 1.00e+00 |
| KEGG | KEGG:00310 | Lysine degradation | 20 | 56 | 1.00e+00 |
| KEGG | KEGG:01212 | Fatty acid metabolism | 15 | 46 | 1.00e+00 |
| KEGG | KEGG:00750 | Vitamin B6 metabolism | 3 | 5 | 1.00e+00 |
| KEGG | KEGG:00760 | Nicotinate and nicotinamide metabolism | 11 | 28 | 1.00e+00 |
| KEGG | KEGG:04022 | cGMP-PKG signaling pathway | 58 | 129 | 1.00e+00 |
| KEGG | KEGG:00785 | Lipoic acid metabolism | 6 | 16 | 1.00e+00 |
| KEGG | KEGG:01232 | Nucleotide metabolism | 31 | 65 | 1.00e+00 |
| KEGG | KEGG:01230 | Biosynthesis of amino acids | 21 | 52 | 1.00e+00 |
| KEGG | KEGG:00790 | Folate biosynthesis | 5 | 18 | 1.00e+00 |
| KEGG | KEGG:01522 | Endocrine resistance | 38 | 82 | 1.00e+00 |
| KEGG | KEGG:04020 | Calcium signaling pathway | 70 | 161 | 1.00e+00 |
| KEGG | KEGG:00600 | Sphingolipid metabolism | 20 | 42 | 1.00e+00 |
| KEGG | KEGG:00640 | Propanoate metabolism | 8 | 27 | 1.00e+00 |
| KEGG | KEGG:03010 | Ribosome | 25 | 121 | 1.00e+00 |
| KEGG | KEGG:01210 | 2-Oxocarboxylic acid metabolism | 10 | 26 | 1.00e+00 |
| KEGG | KEGG:03020 | RNA polymerase | 12 | 33 | 1.00e+00 |
| KEGG | KEGG:01040 | Biosynthesis of unsaturated fatty acids | 10 | 23 | 1.00e+00 |
| KEGG | KEGG:03022 | Basal transcription factors | 16 | 33 | 1.00e+00 |
| KEGG | KEGG:03266 | Virion - Herpesvirus | 1 | 6 | 1.00e+00 |
| KEGG | KEGG:00983 | Drug metabolism - other enzymes | 15 | 40 | 1.00e+00 |
| KEGG | KEGG:00450 | Selenocompound metabolism | 6 | 14 | 1.00e+00 |
| KEGG | KEGG:00590 | Arachidonic acid metabolism | 8 | 25 | 1.00e+00 |
| KEGG | KEGG:00565 | Ether lipid metabolism | 10 | 28 | 1.00e+00 |
| KEGG | KEGG:00630 | Glyoxylate and dicarboxylate metabolism | 6 | 25 | 1.00e+00 |
| KEGG | KEGG:00982 | Drug metabolism - cytochrome P450 | 5 | 16 | 1.00e+00 |
| KEGG | KEGG:00592 | alpha-Linolenic acid metabolism | 4 | 10 | 1.00e+00 |
| KEGG | KEGG:03265 | Virion - Ebolavirus and Lyssavirus | 3 | 5 | 1.00e+00 |
| KEGG | KEGG:00534 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin | 10 | 19 | 1.00e+00 |
| KEGG | KEGG:03040 | Spliceosome | 39 | 124 | 1.00e+00 |
| KEGG | KEGG:00980 | Metabolism of xenobiotics by cytochrome P450 | 8 | 23 | 1.00e+00 |
| KEGG | KEGG:00970 | Aminoacyl-tRNA biosynthesis | 19 | 42 | 1.00e+00 |
| KEGG | KEGG:00500 | Starch and sucrose metabolism | 8 | 22 | 1.00e+00 |
| KEGG | KEGG:03050 | Proteasome | 11 | 40 | 1.00e+00 |
| KEGG | KEGG:03082 | ATP-dependent chromatin remodeling | 43 | 91 | 1.00e+00 |
| KEGG | KEGG:00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 4 | 13 | 1.00e+00 |
| KEGG | KEGG:00620 | Pyruvate metabolism | 9 | 31 | 1.00e+00 |
| KEGG | KEGG:01100 | Metabolic pathways | 445 | 1077 | 1.00e+00 |
| KEGG | KEGG:00440 | Phosphonate and phosphinate metabolism | 2 | 5 | 1.00e+00 |
| KEGG | KEGG:03013 | Nucleocytoplasmic transport | 44 | 96 | 1.00e+00 |
| KEGG | KEGG:00740 | Riboflavin metabolism | 3 | 6 | 1.00e+00 |
| KEGG | KEGG:03450 | Non-homologous end-joining | 6 | 12 | 1.00e+00 |
| KEGG | KEGG:00360 | Phenylalanine metabolism | 2 | 3 | 1.00e+00 |
| KEGG | KEGG:00900 | Terpenoid backbone biosynthesis | 6 | 21 | 1.00e+00 |
| KEGG | KEGG:04060 | Cytokine-cytokine receptor interaction | 40 | 94 | 1.00e+00 |
| KEGG | KEGG:00511 | Other glycan degradation | 2 | 14 | 1.00e+00 |
| KEGG | KEGG:00380 | Tryptophan metabolism | 3 | 21 | 1.00e+00 |
| KEGG | KEGG:03015 | mRNA surveillance pathway | 27 | 80 | 1.00e+00 |
| KEGG | KEGG:00670 | One carbon pool by folate | 7 | 18 | 1.00e+00 |
| KEGG | KEGG:00920 | Sulfur metabolism | 3 | 10 | 1.00e+00 |
| KEGG | KEGG:03018 | RNA degradation | 26 | 67 | 1.00e+00 |
| KEGG | KEGG:00730 | Thiamine metabolism | 4 | 10 | 1.00e+00 |
| KEGG | KEGG:00410 | beta-Alanine metabolism | 10 | 22 | 1.00e+00 |
| KEGG | KEGG:01200 | Carbon metabolism | 26 | 88 | 1.00e+00 |
| KEGG | KEGG:03320 | PPAR signaling pathway | 23 | 47 | 1.00e+00 |
| KEGG | KEGG:03267 | Virion - Adenovirus | 1 | 2 | 1.00e+00 |
| KEGG | KEGG:00430 | Taurine and hypotaurine metabolism | 3 | 8 | 1.00e+00 |
| KEGG | KEGG:00561 | Glycerolipid metabolism | 21 | 44 | 1.00e+00 |
| KEGG | KEGG:00510 | N-Glycan biosynthesis | 11 | 49 | 1.00e+00 |
| KEGG | KEGG:00400 | Phenylalanine, tyrosine and tryptophan biosynthesis | 2 | 2 | 1.00e+00 |
| KEGG | KEGG:00470 | D-Amino acid metabolism | 2 | 4 | 1.00e+00 |
| KEGG | KEGG:04659 | Th17 cell differentiation | 27 | 60 | 1.00e+00 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | 41 | 109 | 1.00e+00 |
| KEGG | KEGG:04979 | Cholesterol metabolism | 11 | 33 | 1.00e+00 |
| KEGG | KEGG:05010 | Alzheimer disease | 102 | 296 | 1.00e+00 |
| KEGG | KEGG:05012 | Parkinson disease | 62 | 211 | 1.00e+00 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | 113 | 291 | 1.00e+00 |
| KEGG | KEGG:05016 | Huntington disease | 82 | 246 | 1.00e+00 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | 46 | 120 | 1.00e+00 |
| KEGG | KEGG:05020 | Prion disease | 63 | 204 | 1.00e+00 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | 137 | 364 | 1.00e+00 |
| KEGG | KEGG:05030 | Cocaine addiction | 16 | 32 | 1.00e+00 |
| KEGG | KEGG:05031 | Amphetamine addiction | 19 | 45 | 1.00e+00 |
| KEGG | KEGG:05033 | Nicotine addiction | 4 | 10 | 1.00e+00 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | 26 | 73 | 1.00e+00 |
| KEGG | KEGG:05110 | Vibrio cholerae infection | 18 | 41 | 1.00e+00 |
| KEGG | KEGG:05120 | Epithelial cell signaling in Helicobacter pylori infection | 24 | 55 | 1.00e+00 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | 59 | 143 | 1.00e+00 |
| KEGG | KEGG:05131 | Shigellosis | 78 | 204 | 1.00e+00 |
| KEGG | KEGG:05132 | Salmonella infection | 82 | 201 | 1.00e+00 |
| KEGG | KEGG:05133 | Pertussis | 15 | 42 | 1.00e+00 |
| KEGG | KEGG:05134 | Legionellosis | 8 | 34 | 1.00e+00 |
| KEGG | KEGG:04977 | Vitamin digestion and absorption | 6 | 13 | 1.00e+00 |
| KEGG | KEGG:05135 | Yersinia infection | 38 | 107 | 1.00e+00 |
| KEGG | KEGG:04975 | Fat digestion and absorption | 6 | 18 | 1.00e+00 |
| KEGG | KEGG:04973 | Carbohydrate digestion and absorption | 12 | 29 | 1.00e+00 |
| KEGG | KEGG:04924 | Renin secretion | 25 | 50 | 1.00e+00 |
| KEGG | KEGG:04925 | Aldosterone synthesis and secretion | 33 | 75 | 1.00e+00 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | 36 | 100 | 1.00e+00 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 36 | 78 | 1.00e+00 |
| KEGG | KEGG:04929 | GnRH secretion | 20 | 50 | 1.00e+00 |
| KEGG | KEGG:04930 | Type II diabetes mellitus | 18 | 35 | 1.00e+00 |
| KEGG | KEGG:04931 | Insulin resistance | 45 | 91 | 1.00e+00 |
| KEGG | KEGG:04932 | Non-alcoholic fatty liver disease | 39 | 126 | 1.00e+00 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | 36 | 87 | 1.00e+00 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | 47 | 96 | 1.00e+00 |
| KEGG | KEGG:04936 | Alcoholic liver disease | 43 | 91 | 1.00e+00 |
| KEGG | KEGG:04950 | Maturity onset diabetes of the young | 2 | 4 | 1.00e+00 |
| KEGG | KEGG:04960 | Aldosterone-regulated sodium reabsorption | 13 | 24 | 1.00e+00 |
| KEGG | KEGG:04961 | Endocrine and other factor-regulated calcium reabsorption | 15 | 40 | 1.00e+00 |
| KEGG | KEGG:04962 | Vasopressin-regulated water reabsorption | 14 | 37 | 1.00e+00 |
| KEGG | KEGG:04964 | Proximal tubule bicarbonate reclamation | 9 | 18 | 1.00e+00 |
| KEGG | KEGG:04970 | Salivary secretion | 23 | 54 | 1.00e+00 |
| KEGG | KEGG:04971 | Gastric acid secretion | 22 | 51 | 1.00e+00 |
| KEGG | KEGG:04972 | Pancreatic secretion | 25 | 57 | 1.00e+00 |
| KEGG | KEGG:04974 | Protein digestion and absorption | 21 | 56 | 1.00e+00 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | 29 | 78 | 1.00e+00 |
| KEGG | KEGG:05140 | Leishmaniasis | 13 | 38 | 1.00e+00 |
| KEGG | KEGG:05143 | African trypanosomiasis | 6 | 16 | 1.00e+00 |
| KEGG | KEGG:05215 | Prostate cancer | 38 | 82 | 1.00e+00 |
| KEGG | KEGG:05219 | Bladder cancer | 10 | 35 | 1.00e+00 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | 34 | 72 | 1.00e+00 |
| KEGG | KEGG:05222 | Small cell lung cancer | 35 | 82 | 1.00e+00 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | 19 | 58 | 1.00e+00 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | 32 | 80 | 1.00e+00 |
| KEGG | KEGG:05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 28 | 65 | 1.00e+00 |
| KEGG | KEGG:05320 | Autoimmune thyroid disease | 1 | 3 | 1.00e+00 |
| KEGG | KEGG:05321 | Inflammatory bowel disease | 8 | 20 | 1.00e+00 |
| KEGG | KEGG:05322 | Systemic lupus erythematosus | 21 | 44 | 1.00e+00 |
| KEGG | KEGG:05323 | Rheumatoid arthritis | 18 | 38 | 1.00e+00 |
| KEGG | KEGG:05330 | Allograft rejection | 1 | 2 | 1.00e+00 |
| KEGG | KEGG:05332 | Graft-versus-host disease | 1 | 2 | 1.00e+00 |
| KEGG | KEGG:05340 | Primary immunodeficiency | 3 | 8 | 1.00e+00 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | 30 | 77 | 1.00e+00 |
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | 29 | 67 | 1.00e+00 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | 31 | 82 | 1.00e+00 |
| KEGG | KEGG:05415 | Diabetic cardiomyopathy | 48 | 158 | 1.00e+00 |
| KEGG | KEGG:05416 | Viral myocarditis | 12 | 36 | 1.00e+00 |
| KEGG | KEGG:05214 | Glioma | 28 | 65 | 1.00e+00 |
| KEGG | KEGG:05142 | Chagas disease | 31 | 72 | 1.00e+00 |
| KEGG | KEGG:05212 | Pancreatic cancer | 35 | 71 | 1.00e+00 |
| KEGG | KEGG:05208 | Chemical carcinogenesis - reactive oxygen species | 46 | 173 | 1.00e+00 |
| KEGG | KEGG:05144 | Malaria | 6 | 20 | 1.00e+00 |
| KEGG | KEGG:05145 | Toxoplasmosis | 24 | 72 | 1.00e+00 |
| KEGG | KEGG:05146 | Amoebiasis | 23 | 62 | 1.00e+00 |
| KEGG | KEGG:05150 | Staphylococcus aureus infection | 4 | 13 | 1.00e+00 |
| KEGG | KEGG:05152 | Tuberculosis | 43 | 101 | 1.00e+00 |
| KEGG | KEGG:05160 | Hepatitis C | 50 | 110 | 1.00e+00 |
| KEGG | KEGG:05162 | Measles | 37 | 85 | 1.00e+00 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | 68 | 160 | 1.00e+00 |
| KEGG | KEGG:05164 | Influenza A | 46 | 95 | 1.00e+00 |
| KEGG | KEGG:05165 | Human papillomavirus infection | 107 | 252 | 1.00e+00 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | 61 | 134 | 1.00e+00 |
| KEGG | KEGG:05168 | Herpes simplex virus 1 infection | 177 | 388 | 1.00e+00 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | 60 | 136 | 1.00e+00 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | 66 | 149 | 1.00e+00 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | 34 | 149 | 1.00e+00 |
| KEGG | KEGG:05200 | Pathways in cancer | 174 | 391 | 1.00e+00 |
| KEGG | KEGG:05204 | Chemical carcinogenesis - DNA adducts | 6 | 20 | 1.00e+00 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 63 | 162 | 1.00e+00 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | 59 | 132 | 1.00e+00 |
| KEGG | KEGG:05211 | Renal cell carcinoma | 25 | 62 | 1.00e+00 |
| KEGG | KEGG:04061 | Viral protein interaction with cytokine and cytokine receptor | 7 | 19 | 1.00e+00 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | 44 | 113 | 1.00e+00 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | 50 | 105 | 1.00e+00 |
| KEGG | KEGG:04260 | Cardiac muscle contraction | 22 | 63 | 1.00e+00 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | 55 | 124 | 1.00e+00 |
| KEGG | KEGG:04270 | Vascular smooth muscle contraction | 31 | 92 | 1.00e+00 |
| KEGG | KEGG:04310 | Wnt signaling pathway | 64 | 133 | 1.00e+00 |
| KEGG | KEGG:04330 | Notch signaling pathway | 25 | 52 | 1.00e+00 |
| KEGG | KEGG:04340 | Hedgehog signaling pathway | 20 | 49 | 1.00e+00 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | 41 | 90 | 1.00e+00 |
| KEGG | KEGG:04360 | Axon guidance | 68 | 155 | 1.00e+00 |
| KEGG | KEGG:04370 | VEGF signaling pathway | 18 | 47 | 1.00e+00 |
| KEGG | KEGG:04371 | Apelin signaling pathway | 38 | 104 | 1.00e+00 |
| KEGG | KEGG:04380 | Osteoclast differentiation | 43 | 92 | 1.00e+00 |
| KEGG | KEGG:04392 | Hippo signaling pathway - multiple species | 13 | 25 | 1.00e+00 |
| KEGG | KEGG:04510 | Focal adhesion | 48 | 169 | 1.00e+00 |
| KEGG | KEGG:04512 | ECM-receptor interaction | 13 | 66 | 1.00e+00 |
| KEGG | KEGG:04514 | Cell adhesion molecules | 24 | 69 | 1.00e+00 |
| KEGG | KEGG:04520 | Adherens junction | 31 | 83 | 1.00e+00 |
| KEGG | KEGG:04530 | Tight junction | 52 | 129 | 1.00e+00 |
| KEGG | KEGG:04540 | Gap junction | 34 | 71 | 1.00e+00 |
| KEGG | KEGG:04610 | Complement and coagulation cascades | 9 | 35 | 1.00e+00 |
| KEGG | KEGG:04218 | Cellular senescence | 64 | 136 | 1.00e+00 |
| KEGG | KEGG:04611 | Platelet activation | 42 | 88 | 1.00e+00 |
| KEGG | KEGG:04215 | Apoptosis - multiple species | 14 | 29 | 1.00e+00 |
| KEGG | KEGG:04211 | Longevity regulating pathway | 35 | 75 | 1.00e+00 |
| KEGG | KEGG:04064 | NF-kappa B signaling pathway | 29 | 61 | 1.00e+00 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | 28 | 86 | 1.00e+00 |
| KEGG | KEGG:04071 | Sphingolipid signaling pathway | 43 | 103 | 1.00e+00 |
| KEGG | KEGG:04072 | Phospholipase D signaling pathway | 47 | 107 | 1.00e+00 |
| KEGG | KEGG:04080 | Neuroactive ligand-receptor interaction | 42 | 101 | 1.00e+00 |
| KEGG | KEGG:04114 | Oocyte meiosis | 49 | 103 | 1.00e+00 |
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | 51 | 127 | 1.00e+00 |
| KEGG | KEGG:04122 | Sulfur relay system | 3 | 8 | 1.00e+00 |
| KEGG | KEGG:04130 | SNARE interactions in vesicular transport | 14 | 31 | 1.00e+00 |
| KEGG | KEGG:04136 | Autophagy - other | 14 | 29 | 1.00e+00 |
| KEGG | KEGG:04137 | Mitophagy - animal | 36 | 94 | 1.00e+00 |
| KEGG | KEGG:04140 | Autophagy - animal | 70 | 149 | 1.00e+00 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | 46 | 149 | 1.00e+00 |
| KEGG | KEGG:04142 | Lysosome | 32 | 109 | 1.00e+00 |
| KEGG | KEGG:04144 | Endocytosis | 92 | 216 | 1.00e+00 |
| KEGG | KEGG:04145 | Phagosome | 34 | 84 | 1.00e+00 |
| KEGG | KEGG:04150 | mTOR signaling pathway | 60 | 129 | 1.00e+00 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | 97 | 250 | 1.00e+00 |
| KEGG | KEGG:04152 | AMPK signaling pathway | 47 | 101 | 1.00e+00 |
| KEGG | KEGG:04213 | Longevity regulating pathway - multiple species | 22 | 50 | 1.00e+00 |
| KEGG | KEGG:04920 | Adipocytokine signaling pathway | 20 | 49 | 1.00e+00 |
| KEGG | KEGG:04612 | Antigen processing and presentation | 8 | 26 | 1.00e+00 |
| KEGG | KEGG:04614 | Renin-angiotensin system | 2 | 10 | 1.00e+00 |
| KEGG | KEGG:04723 | Retrograde endocannabinoid signaling | 32 | 92 | 1.00e+00 |
| KEGG | KEGG:04724 | Glutamatergic synapse | 34 | 74 | 1.00e+00 |
| KEGG | KEGG:04725 | Cholinergic synapse | 38 | 82 | 1.00e+00 |
| KEGG | KEGG:04726 | Serotonergic synapse | 26 | 58 | 1.00e+00 |
| KEGG | KEGG:04727 | GABAergic synapse | 26 | 52 | 1.00e+00 |
| KEGG | KEGG:04728 | Dopaminergic synapse | 37 | 97 | 1.00e+00 |
| KEGG | KEGG:04730 | Long-term depression | 19 | 39 | 1.00e+00 |
| KEGG | KEGG:04740 | Olfactory transduction | 11 | 25 | 1.00e+00 |
| KEGG | KEGG:04742 | Taste transduction | 10 | 20 | 1.00e+00 |
| KEGG | KEGG:04744 | Phototransduction | 6 | 12 | 1.00e+00 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | 58 | 169 | 1.00e+00 |
| KEGG | KEGG:04910 | Insulin signaling pathway | 53 | 113 | 1.00e+00 |
| KEGG | KEGG:04911 | Insulin secretion | 29 | 62 | 1.00e+00 |
| KEGG | KEGG:04912 | GnRH signaling pathway | 29 | 74 | 1.00e+00 |
| KEGG | KEGG:04913 | Ovarian steroidogenesis | 14 | 26 | 1.00e+00 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | 36 | 90 | 1.00e+00 |
| KEGG | KEGG:04916 | Melanogenesis | 32 | 75 | 1.00e+00 |
| KEGG | KEGG:04917 | Prolactin signaling pathway | 26 | 54 | 1.00e+00 |
| KEGG | KEGG:04918 | Thyroid hormone synthesis | 23 | 53 | 1.00e+00 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | 37 | 104 | 1.00e+00 |
| KEGG | KEGG:04613 | Neutrophil extracellular trap formation | 40 | 89 | 1.00e+00 |
| KEGG | KEGG:04721 | Synaptic vesicle cycle | 23 | 49 | 1.00e+00 |
| KEGG | KEGG:04714 | Thermogenesis | 54 | 185 | 1.00e+00 |
| KEGG | KEGG:04620 | Toll-like receptor signaling pathway | 24 | 60 | 1.00e+00 |
| KEGG | KEGG:04621 | NOD-like receptor signaling pathway | 41 | 109 | 1.00e+00 |
| KEGG | KEGG:04622 | RIG-I-like receptor signaling pathway | 14 | 44 | 1.00e+00 |
| KEGG | KEGG:04623 | Cytosolic DNA-sensing pathway | 17 | 46 | 1.00e+00 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | 34 | 74 | 1.00e+00 |
| KEGG | KEGG:04630 | JAK-STAT signaling pathway | 37 | 83 | 1.00e+00 |
| KEGG | KEGG:04640 | Hematopoietic cell lineage | 13 | 28 | 1.00e+00 |
| KEGG | KEGG:04650 | Natural killer cell mediated cytotoxicity | 23 | 53 | 1.00e+00 |
| KEGG | KEGG:04657 | IL-17 signaling pathway | 21 | 55 | 1.00e+00 |
| KEGG | KEGG:04658 | Th1 and Th2 cell differentiation | 23 | 50 | 1.00e+00 |
| KEGG | KEGG:00280 | Valine, leucine and isoleucine degradation | 14 | 42 | 1.00e+00 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | 32 | 84 | 1.00e+00 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | 19 | 52 | 1.00e+00 |
| KEGG | KEGG:04664 | Fc epsilon RI signaling pathway | 14 | 42 | 1.00e+00 |
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | 29 | 75 | 1.00e+00 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | 26 | 76 | 1.00e+00 |
| KEGG | KEGG:04672 | Intestinal immune network for IgA production | 3 | 10 | 1.00e+00 |
| KEGG | KEGG:04710 | Circadian rhythm | 13 | 29 | 1.00e+00 |
| KEGG | KEGG:04713 | Circadian entrainment | 31 | 68 | 1.00e+00 |
| KEGG | KEGG:04720 | Long-term potentiation | 21 | 51 | 1.00e+00 |
| KEGG | KEGG:00270 | Cysteine and methionine metabolism | 17 | 37 | 1.00e+00 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | 41 | 109 | 1.00e+00 |
| KEGG | KEGG:00250 | Alanine, aspartate and glutamate metabolism | 11 | 28 | 1.00e+00 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | 59 | 143 | 1.00e+00 |
| KEGG | KEGG:00260 | Glycine, serine and threonine metabolism | 7 | 26 | 1.00e+00 |
| KEGG | KEGG:00000 | KEGG root term | 2405 | 5451 | 1.00e+00 |
| KEGG | KEGG:00020 | Citrate cycle (TCA cycle) | 7 | 26 | 1.00e+00 |
| KEGG | KEGG:00030 | Pentose phosphate pathway | 9 | 20 | 1.00e+00 |
| KEGG | KEGG:00040 | Pentose and glucuronate interconversions | 2 | 11 | 1.00e+00 |
| KEGG | KEGG:00051 | Fructose and mannose metabolism | 6 | 26 | 1.00e+00 |
| KEGG | KEGG:00052 | Galactose metabolism | 7 | 21 | 1.00e+00 |
| KEGG | KEGG:00053 | Ascorbate and aldarate metabolism | 2 | 8 | 1.00e+00 |
| KEGG | KEGG:00061 | Fatty acid biosynthesis | 3 | 9 | 1.00e+00 |
| KEGG | KEGG:00010 | Glycolysis / Gluconeogenesis | 10 | 41 | 1.00e+00 |
| KEGG | KEGG:00071 | Fatty acid degradation | 8 | 31 | 1.00e+00 |
| KEGG | KEGG:00100 | Steroid biosynthesis | 7 | 15 | 1.00e+00 |
| KEGG | KEGG:00120 | Primary bile acid biosynthesis | 4 | 11 | 1.00e+00 |
| KEGG | KEGG:00130 | Ubiquinone and other terpenoid-quinone biosynthesis | 1 | 9 | 1.00e+00 |
| KEGG | KEGG:00140 | Steroid hormone biosynthesis | 5 | 16 | 1.00e+00 |
| KEGG | KEGG:00190 | Oxidative phosphorylation | 22 | 99 | 1.00e+00 |
| KEGG | KEGG:00240 | Pyrimidine metabolism | 21 | 44 | 1.00e+00 |
| KEGG | KEGG:00062 | Fatty acid elongation | 7 | 22 | 1.00e+00 |
| KEGG | KEGG:00232 | Caffeine metabolism | 1 | 1 | 1.00e+00 |
# intersect(unique(Resp_RNA$ENTREZID), unique(NR_peak_list_20k$ENTREZID)))
NR_int_restable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
slice_head(n=10) %>%
mutate(log10_p=(-log(p_value, base=10))) %>%
ggplot(., aes(x=log10_p, y=reorder(term_name, log10_p)))+
geom_col(fill="#C77CFF")+
theme_bw()+
ylab("")+
xlab(paste0("-log10 p-value"))+
guides(fill="none")+
theme(axis.text.y = element_text(color="black"))+
ggtitle("Intersection NR")
not intersected NR
not_NR_int_resgenes <- gost(query = setdiff(NR_NG_list$ENTREZID, Resp_RNA$ENTREZID),
organism = "hsapiens",
significant = FALSE,
ordered_query = FALSE,
domain_scope = "custom",
measure_underrepresentation = FALSE,
evcodes = FALSE,
user_threshold = 0.05,
correction_method = c("fdr"),
custom_bg = background_df$ENTREZID,
sources=c("GO:BP","KEGG"))
saveRDS(not_NR_int_resgenes,"data/GO_KEGG_analysis/not_NR_int_resgenes.RDS")
not_NR_int_restable <- not_NR_int_resgenes$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
not_NR_int_restable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in NR neargenes intersected with RNA response genes" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:1901564 | organonitrogen compound metabolic process | 2339 | 4354 | 5.62e-04 |
| GO:BP | GO:0002181 | cytoplasmic translation | 99 | 138 | 1.51e-03 |
| GO:BP | GO:0019538 | protein metabolic process | 1946 | 3619 | 2.62e-03 |
| GO:BP | GO:0009060 | aerobic respiration | 108 | 156 | 2.62e-03 |
| GO:BP | GO:0022904 | respiratory electron transport chain | 73 | 98 | 2.62e-03 |
| GO:BP | GO:0019646 | aerobic electron transport chain | 55 | 70 | 2.62e-03 |
| GO:BP | GO:0006119 | oxidative phosphorylation | 82 | 114 | 2.64e-03 |
| GO:BP | GO:1901566 | organonitrogen compound biosynthetic process | 772 | 1369 | 2.64e-03 |
| GO:BP | GO:0045333 | cellular respiration | 132 | 198 | 2.64e-03 |
| GO:BP | GO:0042775 | mitochondrial ATP synthesis coupled electron transport | 59 | 77 | 2.64e-03 |
| GO:BP | GO:0042773 | ATP synthesis coupled electron transport | 59 | 77 | 2.64e-03 |
| GO:BP | GO:0043603 | amide metabolic process | 535 | 928 | 2.85e-03 |
| GO:BP | GO:0009100 | glycoprotein metabolic process | 179 | 285 | 1.32e-02 |
| GO:BP | GO:0006518 | peptide metabolic process | 425 | 734 | 1.43e-02 |
| GO:BP | GO:0006412 | translation | 347 | 590 | 1.43e-02 |
| GO:BP | GO:0043413 | macromolecule glycosylation | 116 | 176 | 1.53e-02 |
| GO:BP | GO:0006486 | protein glycosylation | 116 | 176 | 1.53e-02 |
| GO:BP | GO:0022900 | electron transport chain | 90 | 132 | 1.69e-02 |
| GO:BP | GO:0070085 | glycosylation | 122 | 187 | 1.74e-02 |
| GO:BP | GO:0006487 | protein N-linked glycosylation | 47 | 62 | 2.23e-02 |
| GO:BP | GO:0043604 | amide biosynthetic process | 406 | 705 | 3.07e-02 |
| GO:BP | GO:0043043 | peptide biosynthetic process | 354 | 609 | 3.17e-02 |
not_NR_int_restable %>%
filter(source=="KEGG") %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in NR neargenes intersected with RNA response genes") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:04510 | Focal adhesion | 117 | 169 | 8.46e-05 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | 105 | 149 | 8.46e-05 |
| KEGG | KEGG:03010 | Ribosome | 87 | 121 | 1.34e-04 |
| KEGG | KEGG:04512 | ECM-receptor interaction | 51 | 66 | 5.89e-04 |
| KEGG | KEGG:05208 | Chemical carcinogenesis - reactive oxygen species | 115 | 173 | 9.19e-04 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | 100 | 149 | 1.51e-03 |
| KEGG | KEGG:00190 | Oxidative phosphorylation | 70 | 99 | 1.59e-03 |
| KEGG | KEGG:04714 | Thermogenesis | 119 | 185 | 3.85e-03 |
| KEGG | KEGG:05012 | Parkinson disease | 133 | 211 | 5.40e-03 |
| KEGG | KEGG:05020 | Prion disease | 128 | 204 | 8.56e-03 |
| KEGG | KEGG:00513 | Various types of N-glycan biosynthesis | 29 | 37 | 1.45e-02 |
| KEGG | KEGG:00531 | Glycosaminoglycan degradation | 14 | 15 | 1.61e-02 |
| KEGG | KEGG:05016 | Huntington disease | 149 | 246 | 2.20e-02 |
| KEGG | KEGG:05010 | Alzheimer disease | 176 | 296 | 2.54e-02 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | 105 | 169 | 2.86e-02 |
| KEGG | KEGG:04142 | Lysosome | 71 | 109 | 2.86e-02 |
| KEGG | KEGG:05415 | Diabetic cardiomyopathy | 99 | 158 | 2.86e-02 |
| KEGG | KEGG:00510 | N-Glycan biosynthesis | 35 | 49 | 4.48e-02 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | 210 | 364 | 5.42e-02 |
| KEGG | KEGG:01100 | Metabolic pathways | 582 | 1077 | 1.25e-01 |
| KEGG | KEGG:00511 | Other glycan degradation | 12 | 14 | 1.25e-01 |
| KEGG | KEGG:00514 | Other types of O-glycan biosynthesis | 25 | 35 | 1.35e-01 |
| KEGG | KEGG:05219 | Bladder cancer | 25 | 35 | 1.35e-01 |
| KEGG | KEGG:01200 | Carbon metabolism | 56 | 88 | 1.35e-01 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | 145 | 250 | 1.35e-01 |
| KEGG | KEGG:04932 | Non-alcoholic fatty liver disease | 77 | 126 | 1.37e-01 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | 47 | 73 | 1.47e-01 |
| KEGG | KEGG:00520 | Amino sugar and nucleotide sugar metabolism | 30 | 44 | 1.65e-01 |
| KEGG | KEGG:01250 | Biosynthesis of nucleotide sugars | 24 | 34 | 1.69e-01 |
| KEGG | KEGG:00051 | Fructose and mannose metabolism | 19 | 26 | 1.84e-01 |
| KEGG | KEGG:00010 | Glycolysis / Gluconeogenesis | 28 | 41 | 1.84e-01 |
| KEGG | KEGG:00620 | Pyruvate metabolism | 22 | 31 | 1.84e-01 |
| KEGG | KEGG:03015 | mRNA surveillance pathway | 50 | 80 | 2.12e-01 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | 51 | 82 | 2.16e-01 |
| KEGG | KEGG:04530 | Tight junction | 77 | 129 | 2.16e-01 |
| KEGG | KEGG:04371 | Apelin signaling pathway | 63 | 104 | 2.29e-01 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | 53 | 86 | 2.29e-01 |
| KEGG | KEGG:04270 | Vascular smooth muscle contraction | 56 | 92 | 2.51e-01 |
| KEGG | KEGG:04520 | Adherens junction | 51 | 83 | 2.51e-01 |
| KEGG | KEGG:04723 | Retrograde endocannabinoid signaling | 56 | 92 | 2.51e-01 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | 47 | 76 | 2.58e-01 |
| KEGG | KEGG:05134 | Legionellosis | 23 | 34 | 2.66e-01 |
| KEGG | KEGG:05135 | Yersinia infection | 64 | 107 | 2.66e-01 |
| KEGG | KEGG:00040 | Pentose and glucuronate interconversions | 9 | 11 | 2.81e-01 |
| KEGG | KEGG:00603 | Glycosphingolipid biosynthesis - globo and isoglobo series | 7 | 8 | 2.93e-01 |
| KEGG | KEGG:00071 | Fatty acid degradation | 21 | 31 | 2.99e-01 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | 47 | 77 | 2.99e-01 |
| KEGG | KEGG:00380 | Tryptophan metabolism | 15 | 21 | 3.03e-01 |
| KEGG | KEGG:00512 | Mucin type O-glycan biosynthesis | 15 | 21 | 3.03e-01 |
| KEGG | KEGG:00020 | Citrate cycle (TCA cycle) | 18 | 26 | 3.03e-01 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 93 | 162 | 3.05e-01 |
| KEGG | KEGG:03060 | Protein export | 19 | 28 | 3.27e-01 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | 59 | 100 | 3.28e-01 |
| KEGG | KEGG:04514 | Cell adhesion molecules | 42 | 69 | 3.28e-01 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | 161 | 291 | 3.28e-01 |
| KEGG | KEGG:00280 | Valine, leucine and isoleucine degradation | 27 | 42 | 3.28e-01 |
| KEGG | KEGG:00790 | Folate biosynthesis | 13 | 18 | 3.28e-01 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | 66 | 113 | 3.30e-01 |
| KEGG | KEGG:05146 | Amoebiasis | 38 | 62 | 3.37e-01 |
| KEGG | KEGG:01212 | Fatty acid metabolism | 29 | 46 | 3.45e-01 |
| KEGG | KEGG:00640 | Propanoate metabolism | 18 | 27 | 3.88e-01 |
| KEGG | KEGG:04260 | Cardiac muscle contraction | 38 | 63 | 4.10e-01 |
| KEGG | KEGG:05416 | Viral myocarditis | 23 | 36 | 4.10e-01 |
| KEGG | KEGG:05132 | Salmonella infection | 112 | 201 | 4.10e-01 |
| KEGG | KEGG:04912 | GnRH signaling pathway | 44 | 74 | 4.10e-01 |
| KEGG | KEGG:00604 | Glycosphingolipid biosynthesis - ganglio series | 9 | 12 | 4.16e-01 |
| KEGG | KEGG:00310 | Lysine degradation | 34 | 56 | 4.21e-01 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | 35 | 58 | 4.29e-01 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | 60 | 104 | 4.29e-01 |
| KEGG | KEGG:03050 | Proteasome | 25 | 40 | 4.31e-01 |
| KEGG | KEGG:05131 | Shigellosis | 113 | 204 | 4.38e-01 |
| KEGG | KEGG:04612 | Antigen processing and presentation | 17 | 26 | 4.50e-01 |
| KEGG | KEGG:00130 | Ubiquinone and other terpenoid-quinone biosynthesis | 7 | 9 | 4.58e-01 |
| KEGG | KEGG:04610 | Complement and coagulation cascades | 22 | 35 | 4.61e-01 |
| KEGG | KEGG:00900 | Terpenoid backbone biosynthesis | 14 | 21 | 4.71e-01 |
| KEGG | KEGG:03040 | Spliceosome | 70 | 124 | 4.71e-01 |
| KEGG | KEGG:00000 | KEGG root term | 2785 | 5451 | 4.71e-01 |
| KEGG | KEGG:00052 | Galactose metabolism | 14 | 21 | 4.71e-01 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | 62 | 109 | 4.71e-01 |
| KEGG | KEGG:05145 | Toxoplasmosis | 42 | 72 | 4.89e-01 |
| KEGG | KEGG:00140 | Steroid hormone biosynthesis | 11 | 16 | 4.89e-01 |
| KEGG | KEGG:03266 | Virion - Herpesvirus | 5 | 6 | 4.92e-01 |
| KEGG | KEGG:04144 | Endocytosis | 118 | 216 | 5.15e-01 |
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | 39 | 67 | 5.20e-01 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | 46 | 80 | 5.20e-01 |
| KEGG | KEGG:04974 | Protein digestion and absorption | 33 | 56 | 5.24e-01 |
| KEGG | KEGG:00780 | Biotin metabolism | 3 | 3 | 5.24e-01 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | 48 | 84 | 5.27e-01 |
| KEGG | KEGG:04720 | Long-term potentiation | 30 | 51 | 5.30e-01 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | 79 | 143 | 5.30e-01 |
| KEGG | KEGG:05204 | Chemical carcinogenesis - DNA adducts | 13 | 20 | 5.30e-01 |
| KEGG | KEGG:04961 | Endocrine and other factor-regulated calcium reabsorption | 24 | 40 | 5.30e-01 |
| KEGG | KEGG:00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 9 | 13 | 5.30e-01 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | 61 | 109 | 5.30e-01 |
| KEGG | KEGG:05144 | Malaria | 13 | 20 | 5.30e-01 |
| KEGG | KEGG:05165 | Human papillomavirus infection | 136 | 252 | 5.30e-01 |
| KEGG | KEGG:05200 | Pathways in cancer | 208 | 391 | 5.30e-01 |
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | 43 | 75 | 5.30e-01 |
| KEGG | KEGG:00053 | Ascorbate and aldarate metabolism | 6 | 8 | 5.39e-01 |
| KEGG | KEGG:04664 | Fc epsilon RI signaling pathway | 25 | 42 | 5.43e-01 |
| KEGG | KEGG:04657 | IL-17 signaling pathway | 32 | 55 | 5.45e-01 |
| KEGG | KEGG:04622 | RIG-I-like receptor signaling pathway | 26 | 44 | 5.51e-01 |
| KEGG | KEGG:04979 | Cholesterol metabolism | 20 | 33 | 5.51e-01 |
| KEGG | KEGG:04728 | Dopaminergic synapse | 54 | 97 | 5.84e-01 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | 78 | 143 | 5.84e-01 |
| KEGG | KEGG:04929 | GnRH secretion | 29 | 50 | 5.84e-01 |
| KEGG | KEGG:03018 | RNA degradation | 38 | 67 | 5.84e-01 |
| KEGG | KEGG:04145 | Phagosome | 47 | 84 | 5.84e-01 |
| KEGG | KEGG:00260 | Glycine, serine and threonine metabolism | 16 | 26 | 5.84e-01 |
| KEGG | KEGG:04614 | Renin-angiotensin system | 7 | 10 | 5.84e-01 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | 66 | 120 | 5.84e-01 |
| KEGG | KEGG:04071 | Sphingolipid signaling pathway | 57 | 103 | 5.84e-01 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | 50 | 90 | 6.06e-01 |
| KEGG | KEGG:04360 | Axon guidance | 84 | 155 | 6.08e-01 |
| KEGG | KEGG:04137 | Mitophagy - animal | 52 | 94 | 6.14e-01 |
| KEGG | KEGG:05211 | Renal cell carcinoma | 35 | 62 | 6.30e-01 |
| KEGG | KEGG:04340 | Hedgehog signaling pathway | 28 | 49 | 6.40e-01 |
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | 69 | 127 | 6.40e-01 |
| KEGG | KEGG:00980 | Metabolism of xenobiotics by cytochrome P450 | 14 | 23 | 6.40e-01 |
| KEGG | KEGG:00630 | Glyoxylate and dicarboxylate metabolism | 15 | 25 | 6.66e-01 |
| KEGG | KEGG:00982 | Drug metabolism - cytochrome P450 | 10 | 16 | 6.99e-01 |
| KEGG | KEGG:04072 | Phospholipase D signaling pathway | 58 | 107 | 7.19e-01 |
| KEGG | KEGG:01240 | Biosynthesis of cofactors | 59 | 109 | 7.20e-01 |
| KEGG | KEGG:04975 | Fat digestion and absorption | 11 | 18 | 7.22e-01 |
| KEGG | KEGG:03271 | Virion - Rotavirus | 2 | 2 | 7.23e-01 |
| KEGG | KEGG:03020 | RNA polymerase | 19 | 33 | 7.28e-01 |
| KEGG | KEGG:04060 | Cytokine-cytokine receptor interaction | 51 | 94 | 7.28e-01 |
| KEGG | KEGG:00061 | Fatty acid biosynthesis | 6 | 9 | 7.28e-01 |
| KEGG | KEGG:04962 | Vasopressin-regulated water reabsorption | 21 | 37 | 7.41e-01 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | 85 | 160 | 7.41e-01 |
| KEGG | KEGG:00062 | Fatty acid elongation | 13 | 22 | 7.41e-01 |
| KEGG | KEGG:00500 | Starch and sucrose metabolism | 13 | 22 | 7.41e-01 |
| KEGG | KEGG:04726 | Serotonergic synapse | 32 | 58 | 7.41e-01 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | 47 | 87 | 7.55e-01 |
| KEGG | KEGG:04010 | MAPK signaling pathway | 121 | 231 | 7.55e-01 |
| KEGG | KEGG:05110 | Vibrio cholerae infection | 23 | 41 | 7.55e-01 |
| KEGG | KEGG:04370 | VEGF signaling pathway | 26 | 47 | 7.55e-01 |
| KEGG | KEGG:04713 | Circadian entrainment | 37 | 68 | 7.55e-01 |
| KEGG | KEGG:00760 | Nicotinate and nicotinamide metabolism | 16 | 28 | 7.55e-01 |
| KEGG | KEGG:05150 | Staphylococcus aureus infection | 8 | 13 | 7.55e-01 |
| KEGG | KEGG:00565 | Ether lipid metabolism | 16 | 28 | 7.55e-01 |
| KEGG | KEGG:00250 | Alanine, aspartate and glutamate metabolism | 16 | 28 | 7.55e-01 |
| KEGG | KEGG:04650 | Natural killer cell mediated cytotoxicity | 29 | 53 | 7.64e-01 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | 42 | 78 | 7.64e-01 |
| KEGG | KEGG:04971 | Gastric acid secretion | 28 | 51 | 7.64e-01 |
| KEGG | KEGG:04621 | NOD-like receptor signaling pathway | 58 | 109 | 7.64e-01 |
| KEGG | KEGG:00524 | Neomycin, kanamycin and gentamicin biosynthesis | 3 | 4 | 7.71e-01 |
| KEGG | KEGG:04972 | Pancreatic secretion | 31 | 57 | 7.72e-01 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | 48 | 90 | 7.83e-01 |
| KEGG | KEGG:05140 | Leishmaniasis | 21 | 38 | 7.83e-01 |
| KEGG | KEGG:04014 | Ras signaling pathway | 86 | 164 | 7.83e-01 |
| KEGG | KEGG:03008 | Ribosome biogenesis in eukaryotes | 35 | 65 | 7.83e-01 |
| KEGG | KEGG:05133 | Pertussis | 23 | 42 | 7.95e-01 |
| KEGG | KEGG:04012 | ErbB signaling pathway | 40 | 75 | 8.01e-01 |
| KEGG | KEGG:04916 | Melanogenesis | 40 | 75 | 8.01e-01 |
| KEGG | KEGG:00563 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 13 | 23 | 8.07e-01 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | 28 | 52 | 8.09e-01 |
| KEGG | KEGG:04630 | JAK-STAT signaling pathway | 44 | 83 | 8.09e-01 |
| KEGG | KEGG:00590 | Arachidonic acid metabolism | 14 | 25 | 8.09e-01 |
| KEGG | KEGG:04970 | Salivary secretion | 29 | 54 | 8.12e-01 |
| KEGG | KEGG:04710 | Circadian rhythm | 16 | 29 | 8.24e-01 |
| KEGG | KEGG:00340 | Histidine metabolism | 6 | 10 | 8.50e-01 |
| KEGG | KEGG:04724 | Glutamatergic synapse | 39 | 74 | 8.55e-01 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 41 | 78 | 8.59e-01 |
| KEGG | KEGG:05222 | Small cell lung cancer | 43 | 82 | 8.62e-01 |
| KEGG | KEGG:00601 | Glycosphingolipid biosynthesis - lacto and neolacto series | 8 | 14 | 8.73e-01 |
| KEGG | KEGG:05120 | Epithelial cell signaling in Helicobacter pylori infection | 29 | 55 | 8.87e-01 |
| KEGG | KEGG:04742 | Taste transduction | 11 | 20 | 8.87e-01 |
| KEGG | KEGG:00670 | One carbon pool by folate | 10 | 18 | 8.87e-01 |
| KEGG | KEGG:00532 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 11 | 20 | 8.87e-01 |
| KEGG | KEGG:01523 | Antifolate resistance | 12 | 22 | 8.87e-01 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | 64 | 124 | 8.87e-01 |
| KEGG | KEGG:05321 | Inflammatory bowel disease | 11 | 20 | 8.87e-01 |
| KEGG | KEGG:01210 | 2-Oxocarboxylic acid metabolism | 14 | 26 | 8.88e-01 |
| KEGG | KEGG:04925 | Aldosterone synthesis and secretion | 39 | 75 | 8.88e-01 |
| KEGG | KEGG:04540 | Gap junction | 37 | 71 | 8.88e-01 |
| KEGG | KEGG:04918 | Thyroid hormone synthesis | 27 | 53 | 9.02e-01 |
| KEGG | KEGG:01230 | Biosynthesis of amino acids | 27 | 52 | 9.02e-01 |
| KEGG | KEGG:04310 | Wnt signaling pathway | 67 | 133 | 9.02e-01 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | 53 | 105 | 9.02e-01 |
| KEGG | KEGG:04920 | Adipocytokine signaling pathway | 25 | 49 | 9.02e-01 |
| KEGG | KEGG:01040 | Biosynthesis of unsaturated fatty acids | 12 | 23 | 9.02e-01 |
| KEGG | KEGG:00120 | Primary bile acid biosynthesis | 6 | 11 | 9.02e-01 |
| KEGG | KEGG:04973 | Carbohydrate digestion and absorption | 15 | 29 | 9.02e-01 |
| KEGG | KEGG:00440 | Phosphonate and phosphinate metabolism | 3 | 5 | 9.02e-01 |
| KEGG | KEGG:04659 | Th17 cell differentiation | 31 | 60 | 9.02e-01 |
| KEGG | KEGG:05031 | Amphetamine addiction | 23 | 45 | 9.02e-01 |
| KEGG | KEGG:04623 | Cytosolic DNA-sensing pathway | 24 | 46 | 9.02e-01 |
| KEGG | KEGG:05214 | Glioma | 33 | 65 | 9.02e-01 |
| KEGG | KEGG:00290 | Valine, leucine and isoleucine biosynthesis | 2 | 3 | 9.02e-01 |
| KEGG | KEGG:03013 | Nucleocytoplasmic transport | 49 | 96 | 9.02e-01 |
| KEGG | KEGG:04977 | Vitamin digestion and absorption | 7 | 13 | 9.02e-01 |
| KEGG | KEGG:04215 | Apoptosis - multiple species | 15 | 29 | 9.02e-01 |
| KEGG | KEGG:04061 | Viral protein interaction with cytokine and cytokine receptor | 10 | 19 | 9.02e-01 |
| KEGG | KEGG:04024 | cAMP signaling pathway | 74 | 147 | 9.02e-01 |
| KEGG | KEGG:04022 | cGMP-PKG signaling pathway | 65 | 129 | 9.02e-01 |
| KEGG | KEGG:04020 | Calcium signaling pathway | 82 | 161 | 9.02e-01 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | 83 | 162 | 9.02e-01 |
| KEGG | KEGG:04080 | Neuroactive ligand-receptor interaction | 51 | 101 | 9.02e-01 |
| KEGG | KEGG:04911 | Insulin secretion | 32 | 62 | 9.02e-01 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | 76 | 149 | 9.02e-01 |
| KEGG | KEGG:04136 | Autophagy - other | 15 | 29 | 9.02e-01 |
| KEGG | KEGG:00100 | Steroid biosynthesis | 8 | 15 | 9.02e-01 |
| KEGG | KEGG:04140 | Autophagy - animal | 75 | 149 | 9.02e-01 |
| KEGG | KEGG:05320 | Autoimmune thyroid disease | 2 | 3 | 9.02e-01 |
| KEGG | KEGG:00600 | Sphingolipid metabolism | 22 | 42 | 9.02e-01 |
| KEGG | KEGG:05310 | Asthma | 1 | 1 | 9.02e-01 |
| KEGG | KEGG:04213 | Longevity regulating pathway - multiple species | 26 | 50 | 9.02e-01 |
| KEGG | KEGG:04150 | mTOR signaling pathway | 65 | 129 | 9.02e-01 |
| KEGG | KEGG:03022 | Basal transcription factors | 17 | 33 | 9.02e-01 |
| KEGG | KEGG:04152 | AMPK signaling pathway | 51 | 101 | 9.02e-01 |
| KEGG | KEGG:04730 | Long-term depression | 20 | 39 | 9.02e-01 |
| KEGG | KEGG:04740 | Olfactory transduction | 13 | 25 | 9.02e-01 |
| KEGG | KEGG:03264 | Virion - Flavivirus | 1 | 1 | 9.02e-01 |
| KEGG | KEGG:04611 | Platelet activation | 43 | 88 | 9.26e-01 |
| KEGG | KEGG:04727 | GABAergic synapse | 26 | 52 | 9.26e-01 |
| KEGG | KEGG:04725 | Cholinergic synapse | 40 | 82 | 9.26e-01 |
| KEGG | KEGG:00561 | Glycerolipid metabolism | 22 | 44 | 9.26e-01 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | 67 | 136 | 9.26e-01 |
| KEGG | KEGG:05142 | Chagas disease | 36 | 72 | 9.26e-01 |
| KEGG | KEGG:04640 | Hematopoietic cell lineage | 14 | 28 | 9.26e-01 |
| KEGG | KEGG:05032 | Morphine addiction | 27 | 54 | 9.26e-01 |
| KEGG | KEGG:05340 | Primary immunodeficiency | 4 | 8 | 9.26e-01 |
| KEGG | KEGG:04672 | Intestinal immune network for IgA production | 5 | 10 | 9.26e-01 |
| KEGG | KEGG:00450 | Selenocompound metabolism | 7 | 14 | 9.26e-01 |
| KEGG | KEGG:00270 | Cysteine and methionine metabolism | 18 | 37 | 9.26e-01 |
| KEGG | KEGG:00430 | Taurine and hypotaurine metabolism | 4 | 8 | 9.26e-01 |
| KEGG | KEGG:04721 | Synaptic vesicle cycle | 24 | 49 | 9.26e-01 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | 36 | 72 | 9.26e-01 |
| KEGG | KEGG:05160 | Hepatitis C | 55 | 110 | 9.26e-01 |
| KEGG | KEGG:00330 | Arginine and proline metabolism | 16 | 33 | 9.26e-01 |
| KEGG | KEGG:05152 | Tuberculosis | 50 | 101 | 9.26e-01 |
| KEGG | KEGG:00030 | Pentose phosphate pathway | 10 | 20 | 9.26e-01 |
| KEGG | KEGG:04910 | Insulin signaling pathway | 56 | 113 | 9.26e-01 |
| KEGG | KEGG:00410 | beta-Alanine metabolism | 11 | 22 | 9.26e-01 |
| KEGG | KEGG:05143 | African trypanosomiasis | 8 | 16 | 9.26e-01 |
| KEGG | KEGG:00785 | Lipoic acid metabolism | 8 | 16 | 9.26e-01 |
| KEGG | KEGG:05162 | Measles | 42 | 85 | 9.26e-01 |
| KEGG | KEGG:04930 | Type II diabetes mellitus | 17 | 35 | 9.26e-01 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | 72 | 144 | 9.26e-01 |
| KEGG | KEGG:02010 | ABC transporters | 12 | 24 | 9.26e-01 |
| KEGG | KEGG:04211 | Longevity regulating pathway | 37 | 75 | 9.26e-01 |
| KEGG | KEGG:04122 | Sulfur relay system | 4 | 8 | 9.26e-01 |
| KEGG | KEGG:01522 | Endocrine resistance | 40 | 82 | 9.26e-01 |
| KEGG | KEGG:00730 | Thiamine metabolism | 5 | 10 | 9.26e-01 |
| KEGG | KEGG:04148 | Efferocytosis | 59 | 120 | 9.26e-01 |
| KEGG | KEGG:03082 | ATP-dependent chromatin remodeling | 45 | 91 | 9.26e-01 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | 66 | 132 | 9.26e-01 |
| KEGG | KEGG:00592 | alpha-Linolenic acid metabolism | 5 | 10 | 9.26e-01 |
| KEGG | KEGG:00860 | Porphyrin metabolism | 9 | 18 | 9.26e-01 |
| KEGG | KEGG:04218 | Cellular senescence | 67 | 136 | 9.26e-01 |
| KEGG | KEGG:05215 | Prostate cancer | 40 | 82 | 9.26e-01 |
| KEGG | KEGG:03450 | Non-homologous end-joining | 6 | 12 | 9.26e-01 |
| KEGG | KEGG:00740 | Riboflavin metabolism | 3 | 6 | 9.29e-01 |
| KEGG | KEGG:04392 | Hippo signaling pathway - multiple species | 12 | 25 | 9.35e-01 |
| KEGG | KEGG:04620 | Toll-like receptor signaling pathway | 29 | 60 | 9.38e-01 |
| KEGG | KEGG:04330 | Notch signaling pathway | 25 | 52 | 9.46e-01 |
| KEGG | KEGG:00650 | Butanoate metabolism | 8 | 17 | 9.57e-01 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | 65 | 134 | 9.57e-01 |
| KEGG | KEGG:05323 | Rheumatoid arthritis | 18 | 38 | 9.57e-01 |
| KEGG | KEGG:00983 | Drug metabolism - other enzymes | 19 | 40 | 9.57e-01 |
| KEGG | KEGG:00970 | Aminoacyl-tRNA biosynthesis | 20 | 42 | 9.57e-01 |
| KEGG | KEGG:01232 | Nucleotide metabolism | 31 | 65 | 9.62e-01 |
| KEGG | KEGG:05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 31 | 65 | 9.62e-01 |
| KEGG | KEGG:04064 | NF-kappa B signaling pathway | 29 | 61 | 9.64e-01 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | 46 | 96 | 9.68e-01 |
| KEGG | KEGG:03320 | PPAR signaling pathway | 22 | 47 | 9.74e-01 |
| KEGG | KEGG:04913 | Ovarian steroidogenesis | 12 | 26 | 9.74e-01 |
| KEGG | KEGG:04960 | Aldosterone-regulated sodium reabsorption | 11 | 24 | 9.74e-01 |
| KEGG | KEGG:04934 | Cushing syndrome | 57 | 119 | 9.74e-01 |
| KEGG | KEGG:00350 | Tyrosine metabolism | 5 | 11 | 9.74e-01 |
| KEGG | KEGG:05332 | Graft-versus-host disease | 1 | 2 | 9.77e-01 |
| KEGG | KEGG:05330 | Allograft rejection | 1 | 2 | 9.77e-01 |
| KEGG | KEGG:03267 | Virion - Adenovirus | 1 | 2 | 9.77e-01 |
| KEGG | KEGG:04917 | Prolactin signaling pathway | 25 | 54 | 9.83e-01 |
| KEGG | KEGG:04924 | Renin secretion | 23 | 50 | 9.83e-01 |
| KEGG | KEGG:05210 | Colorectal cancer | 38 | 81 | 9.83e-01 |
| KEGG | KEGG:04927 | Cortisol synthesis and secretion | 21 | 46 | 9.83e-01 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | 65 | 137 | 9.83e-01 |
| KEGG | KEGG:05212 | Pancreatic cancer | 33 | 71 | 9.83e-01 |
| KEGG | KEGG:04658 | Th1 and Th2 cell differentiation | 23 | 50 | 9.83e-01 |
| KEGG | KEGG:04936 | Alcoholic liver disease | 43 | 91 | 9.83e-01 |
| KEGG | KEGG:00591 | Linoleic acid metabolism | 3 | 7 | 9.83e-01 |
| KEGG | KEGG:04390 | Hippo signaling pathway | 61 | 129 | 9.83e-01 |
| KEGG | KEGG:00240 | Pyrimidine metabolism | 20 | 44 | 9.83e-01 |
| KEGG | KEGG:04964 | Proximal tubule bicarbonate reclamation | 8 | 18 | 9.83e-01 |
| KEGG | KEGG:05168 | Herpes simplex virus 1 infection | 181 | 388 | 9.99e-01 |
| KEGG | KEGG:05322 | Systemic lupus erythematosus | 15 | 44 | 9.99e-01 |
| KEGG | KEGG:05226 | Gastric cancer | 49 | 113 | 9.99e-01 |
| KEGG | KEGG:05217 | Basal cell carcinoma | 16 | 48 | 9.99e-01 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | 52 | 122 | 9.99e-01 |
| KEGG | KEGG:05161 | Hepatitis B | 56 | 126 | 9.99e-01 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | 28 | 64 | 9.99e-01 |
| KEGG | KEGG:05203 | Viral carcinogenesis | 64 | 142 | 9.99e-01 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | 70 | 164 | 9.99e-01 |
| KEGG | KEGG:05224 | Breast cancer | 46 | 113 | 9.99e-01 |
| KEGG | KEGG:05216 | Thyroid cancer | 14 | 33 | 9.99e-01 |
| KEGG | KEGG:05218 | Melanoma | 23 | 56 | 9.99e-01 |
| KEGG | KEGG:05221 | Acute myeloid leukemia | 18 | 52 | 9.99e-01 |
| KEGG | KEGG:05164 | Influenza A | 43 | 95 | 9.99e-01 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | 30 | 82 | 9.99e-01 |
| KEGG | KEGG:05213 | Endometrial cancer | 23 | 54 | 9.99e-01 |
| KEGG | KEGG:04976 | Bile secretion | 18 | 41 | 9.99e-01 |
| KEGG | KEGG:04978 | Mineral absorption | 16 | 38 | 9.99e-01 |
| KEGG | KEGG:04114 | Oocyte meiosis | 45 | 103 | 9.99e-01 |
| KEGG | KEGG:04115 | p53 signaling pathway | 21 | 66 | 9.99e-01 |
| KEGG | KEGG:00564 | Glycerophospholipid metabolism | 27 | 71 | 9.99e-01 |
| KEGG | KEGG:00562 | Inositol phosphate metabolism | 25 | 60 | 9.99e-01 |
| KEGG | KEGG:04130 | SNARE interactions in vesicular transport | 13 | 31 | 9.99e-01 |
| KEGG | KEGG:04110 | Cell cycle | 55 | 146 | 9.99e-01 |
| KEGG | KEGG:04146 | Peroxisome | 29 | 66 | 9.99e-01 |
| KEGG | KEGG:00515 | Mannose type O-glycan biosynthesis | 8 | 19 | 9.99e-01 |
| KEGG | KEGG:05033 | Nicotine addiction | 4 | 10 | 9.99e-01 |
| KEGG | KEGG:05034 | Alcoholism | 37 | 102 | 9.99e-01 |
| KEGG | KEGG:00480 | Glutathione metabolism | 17 | 39 | 9.99e-01 |
| KEGG | KEGG:00470 | D-Amino acid metabolism | 1 | 4 | 9.99e-01 |
| KEGG | KEGG:00360 | Phenylalanine metabolism | 1 | 3 | 9.99e-01 |
| KEGG | KEGG:00230 | Purine metabolism | 36 | 93 | 9.99e-01 |
| KEGG | KEGG:00534 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin | 8 | 19 | 9.99e-01 |
| KEGG | KEGG:00750 | Vitamin B6 metabolism | 2 | 5 | 9.99e-01 |
| KEGG | KEGG:04070 | Phosphatidylinositol signaling system | 34 | 83 | 9.99e-01 |
| KEGG | KEGG:00770 | Pantothenate and CoA biosynthesis | 6 | 15 | 9.99e-01 |
| KEGG | KEGG:03250 | Viral life cycle - HIV-1 | 21 | 54 | 9.99e-01 |
| KEGG | KEGG:03265 | Virion - Ebolavirus and Lyssavirus | 2 | 5 | 9.99e-01 |
| KEGG | KEGG:04950 | Maturity onset diabetes of the young | 1 | 4 | 9.99e-01 |
| KEGG | KEGG:03030 | DNA replication | 9 | 34 | 9.99e-01 |
| KEGG | KEGG:03410 | Base excision repair | 13 | 44 | 9.99e-01 |
| KEGG | KEGG:03420 | Nucleotide excision repair | 23 | 54 | 9.99e-01 |
| KEGG | KEGG:03430 | Mismatch repair | 6 | 22 | 9.99e-01 |
| KEGG | KEGG:03440 | Homologous recombination | 15 | 38 | 9.99e-01 |
| KEGG | KEGG:01524 | Platinum drug resistance | 21 | 60 | 9.99e-01 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | 31 | 72 | 9.99e-01 |
| KEGG | KEGG:03460 | Fanconi anemia pathway | 18 | 46 | 9.99e-01 |
| KEGG | KEGG:04940 | Type I diabetes mellitus | 2 | 7 | 9.99e-01 |
| KEGG | KEGG:04966 | Collecting duct acid secretion | 5 | 18 | 9.99e-01 |
| KEGG | KEGG:00920 | Sulfur metabolism | 4 | 10 | 9.99e-01 |
| KEGG | KEGG:04068 | FoxO signaling pathway | 46 | 106 | 9.99e-01 |
| KEGG | KEGG:00910 | Nitrogen metabolism | 2 | 8 | 9.99e-01 |
| KEGG | KEGG:00830 | Retinol metabolism | 3 | 14 | 9.99e-01 |
| KEGG | KEGG:00220 | Arginine biosynthesis | 5 | 15 | 9.99e-01 |
| KEGG | KEGG:04210 | Apoptosis | 49 | 112 | 9.99e-01 |
| KEGG | KEGG:05030 | Cocaine addiction | 13 | 32 | 9.99e-01 |
| KEGG | KEGG:03083 | Polycomb repressive complex | 31 | 70 | 9.99e-01 |
| KEGG | KEGG:04380 | Osteoclast differentiation | 42 | 92 | 9.99e-01 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | 43 | 101 | 9.99e-01 |
| KEGG | KEGG:04923 | Regulation of lipolysis in adipocytes | 14 | 41 | 9.99e-01 |
| KEGG | KEGG:04216 | Ferroptosis | 12 | 31 | 9.99e-01 |
| KEGG | KEGG:04613 | Neutrophil extracellular trap formation | 37 | 89 | 9.99e-01 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | 34 | 74 | 9.99e-01 |
| KEGG | KEGG:04668 | TNF signaling pathway | 34 | 83 | 9.99e-01 |
| KEGG | KEGG:04744 | Phototransduction | 5 | 12 | 9.99e-01 |
| KEGG | KEGG:04931 | Insulin resistance | 41 | 91 | 9.99e-01 |
| KEGG | KEGG:04217 | Necroptosis | 41 | 99 | 9.99e-01 |
| KEGG | KEGG:04750 | Inflammatory mediator regulation of TRP channels | 31 | 72 | 9.99e-01 |
| KEGG | KEGG:04814 | Motor proteins | 65 | 141 | 9.99e-01 |
# intersect(unique(Resp_RNA$ENTREZID), unique(NR_peak_list_20k$ENTREZID)))
not_NR_int_restable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
slice_head(n=10) %>%
mutate(log10_p=(-log(p_value, base=10))) %>%
ggplot(., aes(x=log10_p, y=reorder(term_name, log10_p)))+
geom_col(fill="#C77CFF")+
theme_bw()+
ylab("")+
xlab(paste0("-log10 p-value"))+
guides(fill="none")+
theme(axis.text.y = element_text(color="black"))+
ggtitle("not Intersection NR")
not intersected LR
not_LR_int_resgenes <- gost(query =setdiff(LR_NG_list$ENTREZID, Resp_RNA$ENTREZID),
organism = "hsapiens",
significant = FALSE,
ordered_query = FALSE,
domain_scope = "custom",
measure_underrepresentation = FALSE,
evcodes = FALSE,
user_threshold = 0.05,
correction_method = c("fdr"),
custom_bg = background_df$ENTREZID,
sources=c("GO:BP","KEGG"))
saveRDS(not_LR_int_resgenes,"data/GO_KEGG_analysis/not_LR_int_resgenes.RDS")
not_LR_int_restable <- not_LR_int_resgenes$result %>%
dplyr::select(c(source, term_id,
term_name,intersection_size,
term_size, p_value))# %>%
not_LR_int_restable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(.,caption = "GO:BP terms found in LR neargenes intersected with RNA response genes" ) %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| GO:BP | GO:0032501 | multicellular organismal process | 1659 | 4504 | 2.80e-07 |
| GO:BP | GO:0048856 | anatomical structure development | 1430 | 3867 | 3.35e-06 |
| GO:BP | GO:0048812 | neuron projection morphogenesis | 220 | 479 | 3.69e-06 |
| GO:BP | GO:0006897 | endocytosis | 226 | 492 | 3.69e-06 |
| GO:BP | GO:0120039 | plasma membrane bounded cell projection morphogenesis | 226 | 494 | 3.69e-06 |
| GO:BP | GO:0098657 | import into cell | 276 | 622 | 3.69e-06 |
| GO:BP | GO:0048858 | cell projection morphogenesis | 226 | 498 | 6.96e-06 |
| GO:BP | GO:0007155 | cell adhesion | 393 | 941 | 7.01e-06 |
| GO:BP | GO:0048731 | system development | 1026 | 2719 | 7.01e-06 |
| GO:BP | GO:0048667 | cell morphogenesis involved in neuron differentiation | 200 | 435 | 1.10e-05 |
| GO:BP | GO:0000902 | cell morphogenesis | 306 | 713 | 1.23e-05 |
| GO:BP | GO:0032502 | developmental process | 1523 | 4179 | 1.34e-05 |
| GO:BP | GO:0007275 | multicellular organism development | 1177 | 3170 | 1.70e-05 |
| GO:BP | GO:0007399 | nervous system development | 689 | 1775 | 2.38e-05 |
| GO:BP | GO:0032989 | cellular anatomical entity morphogenesis | 256 | 588 | 3.31e-05 |
| GO:BP | GO:0045229 | external encapsulating structure organization | 113 | 224 | 3.39e-05 |
| GO:BP | GO:0030198 | extracellular matrix organization | 112 | 223 | 4.94e-05 |
| GO:BP | GO:0043062 | extracellular structure organization | 112 | 224 | 6.33e-05 |
| GO:BP | GO:0031175 | neuron projection development | 311 | 743 | 1.04e-04 |
| GO:BP | GO:0007409 | axonogenesis | 156 | 337 | 1.37e-04 |
| GO:BP | GO:0048666 | neuron development | 345 | 838 | 1.45e-04 |
| GO:BP | GO:0006810 | transport | 1101 | 2984 | 1.71e-04 |
| GO:BP | GO:0009653 | anatomical structure morphogenesis | 704 | 1844 | 2.01e-04 |
| GO:BP | GO:0030182 | neuron differentiation | 408 | 1014 | 2.01e-04 |
| GO:BP | GO:0061564 | axon development | 168 | 372 | 2.81e-04 |
| GO:BP | GO:0022008 | neurogenesis | 492 | 1251 | 2.95e-04 |
| GO:BP | GO:0007160 | cell-matrix adhesion | 86 | 169 | 4.87e-04 |
| GO:BP | GO:0048699 | generation of neurons | 427 | 1076 | 5.40e-04 |
| GO:BP | GO:0016192 | vesicle-mediated transport | 454 | 1152 | 5.78e-04 |
| GO:BP | GO:0007229 | integrin-mediated signaling pathway | 49 | 86 | 1.61e-03 |
| GO:BP | GO:0023052 | signaling | 1402 | 3918 | 3.97e-03 |
| GO:BP | GO:0030030 | cell projection organization | 458 | 1182 | 3.97e-03 |
| GO:BP | GO:0120036 | plasma membrane bounded cell projection organization | 446 | 1150 | 4.34e-03 |
| GO:BP | GO:0051234 | establishment of localization | 1171 | 3240 | 4.34e-03 |
| GO:BP | GO:0048870 | cell motility | 435 | 1120 | 4.59e-03 |
| GO:BP | GO:0098609 | cell-cell adhesion | 233 | 564 | 5.86e-03 |
| GO:BP | GO:0065005 | protein-lipid complex assembly | 16 | 20 | 6.70e-03 |
| GO:BP | GO:0007154 | cell communication | 1420 | 3983 | 6.77e-03 |
| GO:BP | GO:0097485 | neuron projection guidance | 83 | 172 | 6.81e-03 |
| GO:BP | GO:0007411 | axon guidance | 83 | 172 | 6.81e-03 |
| GO:BP | GO:0002062 | chondrocyte differentiation | 48 | 88 | 7.20e-03 |
| GO:BP | GO:0051336 | regulation of hydrolase activity | 182 | 431 | 9.59e-03 |
| GO:BP | GO:0071711 | basement membrane organization | 23 | 34 | 9.89e-03 |
| GO:BP | GO:0008150 | biological_process | 3787 | 11244 | 9.89e-03 |
| GO:BP | GO:0031589 | cell-substrate adhesion | 116 | 258 | 1.04e-02 |
| GO:BP | GO:0030001 | metal ion transport | 216 | 524 | 1.08e-02 |
| GO:BP | GO:0030154 | cell differentiation | 1015 | 2803 | 1.08e-02 |
| GO:BP | GO:0006898 | receptor-mediated endocytosis | 86 | 182 | 1.08e-02 |
| GO:BP | GO:0016477 | cell migration | 392 | 1011 | 1.08e-02 |
| GO:BP | GO:0048869 | cellular developmental process | 1015 | 2804 | 1.13e-02 |
| GO:BP | GO:0065008 | regulation of biological quality | 701 | 1893 | 1.19e-02 |
| GO:BP | GO:0150115 | cell-substrate junction organization | 50 | 95 | 1.36e-02 |
| GO:BP | GO:0007044 | cell-substrate junction assembly | 47 | 88 | 1.36e-02 |
| GO:BP | GO:0003008 | system process | 435 | 1139 | 1.86e-02 |
| GO:BP | GO:0034220 | monoatomic ion transmembrane transport | 237 | 587 | 1.94e-02 |
| GO:BP | GO:0051049 | regulation of transport | 420 | 1098 | 2.04e-02 |
| GO:BP | GO:0060627 | regulation of vesicle-mediated transport | 158 | 374 | 2.20e-02 |
| GO:BP | GO:0030100 | regulation of endocytosis | 90 | 196 | 2.25e-02 |
| GO:BP | GO:0006812 | monoatomic cation transport | 246 | 614 | 2.40e-02 |
| GO:BP | GO:0034377 | plasma lipoprotein particle assembly | 14 | 18 | 2.43e-02 |
| GO:BP | GO:0051179 | localization | 1324 | 3731 | 2.58e-02 |
| GO:BP | GO:0006811 | monoatomic ion transport | 283 | 719 | 3.10e-02 |
| GO:BP | GO:0098655 | monoatomic cation transmembrane transport | 201 | 495 | 3.91e-02 |
| GO:BP | GO:0043413 | macromolecule glycosylation | 81 | 176 | 3.91e-02 |
| GO:BP | GO:0006486 | protein glycosylation | 81 | 176 | 3.91e-02 |
| GO:BP | GO:0055085 | transmembrane transport | 354 | 921 | 4.07e-02 |
| GO:BP | GO:0023051 | regulation of signaling | 881 | 2438 | 4.12e-02 |
| GO:BP | GO:0030199 | collagen fibril organization | 29 | 50 | 4.13e-02 |
| GO:BP | GO:0040012 | regulation of locomotion | 282 | 720 | 4.19e-02 |
| GO:BP | GO:0009987 | cellular process | 3604 | 10686 | 4.28e-02 |
| GO:BP | GO:0007165 | signal transduction | 1279 | 3611 | 4.46e-02 |
| GO:BP | GO:0040011 | locomotion | 312 | 805 | 4.46e-02 |
| GO:BP | GO:0045663 | positive regulation of myoblast differentiation | 22 | 35 | 4.46e-02 |
| GO:BP | GO:0007267 | cell-cell signaling | 410 | 1082 | 4.62e-02 |
| GO:BP | GO:0090109 | regulation of cell-substrate junction assembly | 31 | 55 | 4.64e-02 |
| GO:BP | GO:0051893 | regulation of focal adhesion assembly | 31 | 55 | 4.64e-02 |
| GO:BP | GO:2000145 | regulation of cell motility | 274 | 700 | 4.79e-02 |
| GO:BP | GO:0072337 | modified amino acid transport | 19 | 29 | 4.88e-02 |
| GO:BP | GO:0010646 | regulation of cell communication | 881 | 2444 | 4.88e-02 |
| GO:BP | GO:0007166 | cell surface receptor signaling pathway | 660 | 1801 | 4.88e-02 |
| GO:BP | GO:0051016 | barbed-end actin filament capping | 14 | 19 | 4.88e-02 |
not_LR_int_restable %>%
filter(source=="KEGG") %>%
mutate_at(.vars = 6, .funs = scientific_format()) %>%
kable(., caption = "KEGG terms found in LR neargenes intersected with RNA response genes") %>%
kable_paper("striped", full_width = FALSE) %>%
kable_styling(
full_width = FALSE,
position = "left",
bootstrap_options = c("striped", "hover")
) %>%
scroll_box(width = "100%", height = "400px")| source | term_id | term_name | intersection_size | term_size | p_value |
|---|---|---|---|---|---|
| KEGG | KEGG:04510 | Focal adhesion | 103 | 169 | 2.97e-11 |
| KEGG | KEGG:04512 | ECM-receptor interaction | 46 | 66 | 2.18e-07 |
| KEGG | KEGG:04810 | Regulation of actin cytoskeleton | 87 | 169 | 6.40e-05 |
| KEGG | KEGG:04270 | Vascular smooth muscle contraction | 53 | 92 | 9.91e-05 |
| KEGG | KEGG:04520 | Adherens junction | 47 | 83 | 6.01e-04 |
| KEGG | KEGG:05205 | Proteoglycans in cancer | 77 | 162 | 5.28e-03 |
| KEGG | KEGG:04151 | PI3K-Akt signaling pathway | 111 | 250 | 5.77e-03 |
| KEGG | KEGG:05146 | Amoebiasis | 34 | 62 | 1.48e-02 |
| KEGG | KEGG:04720 | Long-term potentiation | 29 | 51 | 1.58e-02 |
| KEGG | KEGG:04974 | Protein digestion and absorption | 31 | 56 | 1.68e-02 |
| KEGG | KEGG:04371 | Apelin signaling pathway | 51 | 104 | 1.68e-02 |
| KEGG | KEGG:05135 | Yersinia infection | 52 | 107 | 1.68e-02 |
| KEGG | KEGG:05100 | Bacterial invasion of epithelial cells | 38 | 73 | 1.68e-02 |
| KEGG | KEGG:00514 | Other types of O-glycan biosynthesis | 21 | 35 | 2.44e-02 |
| KEGG | KEGG:04360 | Axon guidance | 70 | 155 | 2.63e-02 |
| KEGG | KEGG:05200 | Pathways in cancer | 158 | 391 | 2.82e-02 |
| KEGG | KEGG:04926 | Relaxin signaling pathway | 48 | 100 | 2.83e-02 |
| KEGG | KEGG:00512 | Mucin type O-glycan biosynthesis | 14 | 21 | 2.95e-02 |
| KEGG | KEGG:05131 | Shigellosis | 88 | 204 | 2.95e-02 |
| KEGG | KEGG:04670 | Leukocyte transendothelial migration | 38 | 76 | 2.95e-02 |
| KEGG | KEGG:04022 | cGMP-PKG signaling pathway | 59 | 129 | 3.07e-02 |
| KEGG | KEGG:05414 | Dilated cardiomyopathy | 40 | 82 | 3.65e-02 |
| KEGG | KEGG:04014 | Ras signaling pathway | 72 | 164 | 3.70e-02 |
| KEGG | KEGG:04971 | Gastric acid secretion | 27 | 51 | 3.82e-02 |
| KEGG | KEGG:00051 | Fructose and mannose metabolism | 16 | 26 | 3.82e-02 |
| KEGG | KEGG:04921 | Oxytocin signaling pathway | 52 | 113 | 3.82e-02 |
| KEGG | KEGG:04024 | cAMP signaling pathway | 65 | 147 | 4.04e-02 |
| KEGG | KEGG:04144 | Endocytosis | 91 | 216 | 4.07e-02 |
| KEGG | KEGG:00604 | Glycosphingolipid biosynthesis - ganglio series | 9 | 12 | 4.10e-02 |
| KEGG | KEGG:04722 | Neurotrophin signaling pathway | 48 | 104 | 4.10e-02 |
| KEGG | KEGG:04020 | Calcium signaling pathway | 70 | 161 | 4.10e-02 |
| KEGG | KEGG:04961 | Endocrine and other factor-regulated calcium reabsorption | 22 | 40 | 4.10e-02 |
| KEGG | KEGG:05410 | Hypertrophic cardiomyopathy | 37 | 77 | 4.80e-02 |
| KEGG | KEGG:01212 | Fatty acid metabolism | 24 | 46 | 5.94e-02 |
| KEGG | KEGG:04015 | Rap1 signaling pathway | 69 | 162 | 7.05e-02 |
| KEGG | KEGG:04664 | Fc epsilon RI signaling pathway | 22 | 42 | 7.18e-02 |
| KEGG | KEGG:04660 | T cell receptor signaling pathway | 39 | 84 | 7.18e-02 |
| KEGG | KEGG:04728 | Dopaminergic synapse | 44 | 97 | 7.23e-02 |
| KEGG | KEGG:04933 | AGE-RAGE signaling pathway in diabetic complications | 40 | 87 | 7.47e-02 |
| KEGG | KEGG:05412 | Arrhythmogenic right ventricular cardiomyopathy | 32 | 67 | 7.49e-02 |
| KEGG | KEGG:04010 | MAPK signaling pathway | 94 | 231 | 7.49e-02 |
| KEGG | KEGG:04972 | Pancreatic secretion | 28 | 57 | 7.49e-02 |
| KEGG | KEGG:05031 | Amphetamine addiction | 23 | 45 | 7.61e-02 |
| KEGG | KEGG:05231 | Choline metabolism in cancer | 37 | 80 | 7.72e-02 |
| KEGG | KEGG:04925 | Aldosterone synthesis and secretion | 35 | 75 | 7.72e-02 |
| KEGG | KEGG:00071 | Fatty acid degradation | 17 | 31 | 7.79e-02 |
| KEGG | KEGG:05416 | Viral myocarditis | 19 | 36 | 7.84e-02 |
| KEGG | KEGG:04713 | Circadian entrainment | 32 | 68 | 7.84e-02 |
| KEGG | KEGG:04062 | Chemokine signaling pathway | 48 | 109 | 7.84e-02 |
| KEGG | KEGG:04726 | Serotonergic synapse | 28 | 58 | 7.84e-02 |
| KEGG | KEGG:04141 | Protein processing in endoplasmic reticulum | 63 | 149 | 7.84e-02 |
| KEGG | KEGG:04918 | Thyroid hormone synthesis | 26 | 53 | 7.84e-02 |
| KEGG | KEGG:04072 | Phospholipase D signaling pathway | 47 | 107 | 8.21e-02 |
| KEGG | KEGG:04530 | Tight junction | 55 | 129 | 9.29e-02 |
| KEGG | KEGG:04912 | GnRH signaling pathway | 34 | 74 | 9.29e-02 |
| KEGG | KEGG:04662 | B cell receptor signaling pathway | 25 | 52 | 9.63e-02 |
| KEGG | KEGG:04370 | VEGF signaling pathway | 23 | 47 | 9.63e-02 |
| KEGG | KEGG:03266 | Virion - Herpesvirus | 5 | 6 | 9.63e-02 |
| KEGG | KEGG:00280 | Valine, leucine and isoleucine degradation | 21 | 42 | 9.63e-02 |
| KEGG | KEGG:04611 | Platelet activation | 39 | 88 | 9.63e-02 |
| KEGG | KEGG:04915 | Estrogen signaling pathway | 40 | 90 | 9.63e-02 |
| KEGG | KEGG:04261 | Adrenergic signaling in cardiomyocytes | 53 | 124 | 9.63e-02 |
| KEGG | KEGG:00513 | Various types of N-glycan biosynthesis | 19 | 37 | 9.63e-02 |
| KEGG | KEGG:04142 | Lysosome | 47 | 109 | 9.63e-02 |
| KEGG | KEGG:05163 | Human cytomegalovirus infection | 66 | 160 | 9.63e-02 |
| KEGG | KEGG:04666 | Fc gamma R-mediated phagocytosis | 34 | 75 | 9.63e-02 |
| KEGG | KEGG:04911 | Insulin secretion | 29 | 62 | 9.63e-02 |
| KEGG | KEGG:05219 | Bladder cancer | 18 | 35 | 9.74e-02 |
| KEGG | KEGG:04928 | Parathyroid hormone synthesis, secretion and action | 35 | 78 | 1.01e-01 |
| KEGG | KEGG:04929 | GnRH secretion | 24 | 50 | 1.01e-01 |
| KEGG | KEGG:04979 | Cholesterol metabolism | 17 | 33 | 1.08e-01 |
| KEGG | KEGG:04723 | Retrograde endocannabinoid signaling | 40 | 92 | 1.17e-01 |
| KEGG | KEGG:04514 | Cell adhesion molecules | 31 | 69 | 1.29e-01 |
| KEGG | KEGG:04970 | Salivary secretion | 25 | 54 | 1.41e-01 |
| KEGG | KEGG:04340 | Hedgehog signaling pathway | 23 | 49 | 1.42e-01 |
| KEGG | KEGG:00062 | Fatty acid elongation | 12 | 22 | 1.43e-01 |
| KEGG | KEGG:04012 | ErbB signaling pathway | 33 | 75 | 1.44e-01 |
| KEGG | KEGG:00640 | Propanoate metabolism | 14 | 27 | 1.52e-01 |
| KEGG | KEGG:04066 | HIF-1 signaling pathway | 37 | 86 | 1.53e-01 |
| KEGG | KEGG:04919 | Thyroid hormone signaling pathway | 44 | 105 | 1.59e-01 |
| KEGG | KEGG:04071 | Sphingolipid signaling pathway | 43 | 103 | 1.76e-01 |
| KEGG | KEGG:05230 | Central carbon metabolism in cancer | 26 | 58 | 1.77e-01 |
| KEGG | KEGG:04724 | Glutamatergic synapse | 32 | 74 | 1.84e-01 |
| KEGG | KEGG:05418 | Fluid shear stress and atherosclerosis | 45 | 109 | 1.86e-01 |
| KEGG | KEGG:04916 | Melanogenesis | 32 | 75 | 2.16e-01 |
| KEGG | KEGG:05211 | Renal cell carcinoma | 27 | 62 | 2.25e-01 |
| KEGG | KEGG:04920 | Adipocytokine signaling pathway | 22 | 49 | 2.28e-01 |
| KEGG | KEGG:00520 | Amino sugar and nucleotide sugar metabolism | 20 | 44 | 2.36e-01 |
| KEGG | KEGG:05415 | Diabetic cardiomyopathy | 62 | 158 | 2.39e-01 |
| KEGG | KEGG:04730 | Long-term depression | 18 | 39 | 2.39e-01 |
| KEGG | KEGG:05222 | Small cell lung cancer | 34 | 82 | 2.61e-01 |
| KEGG | KEGG:04725 | Cholinergic synapse | 34 | 82 | 2.61e-01 |
| KEGG | KEGG:05165 | Human papillomavirus infection | 95 | 252 | 2.61e-01 |
| KEGG | KEGG:04924 | Renin secretion | 22 | 50 | 2.63e-01 |
| KEGG | KEGG:04614 | Renin-angiotensin system | 6 | 10 | 2.68e-01 |
| KEGG | KEGG:05130 | Pathogenic Escherichia coli infection | 56 | 143 | 2.68e-01 |
| KEGG | KEGG:05417 | Lipid and atherosclerosis | 56 | 143 | 2.68e-01 |
| KEGG | KEGG:04650 | Natural killer cell mediated cytotoxicity | 23 | 53 | 2.71e-01 |
| KEGG | KEGG:00000 | KEGG root term | 1843 | 5451 | 2.79e-01 |
| KEGG | KEGG:04930 | Type II diabetes mellitus | 16 | 35 | 2.84e-01 |
| KEGG | KEGG:04630 | JAK-STAT signaling pathway | 34 | 83 | 2.84e-01 |
| KEGG | KEGG:00531 | Glycosaminoglycan degradation | 8 | 15 | 2.89e-01 |
| KEGG | KEGG:04310 | Wnt signaling pathway | 52 | 133 | 2.89e-01 |
| KEGG | KEGG:04922 | Glucagon signaling pathway | 32 | 78 | 2.93e-01 |
| KEGG | KEGG:04742 | Taste transduction | 10 | 20 | 2.94e-01 |
| KEGG | KEGG:04927 | Cortisol synthesis and secretion | 20 | 46 | 3.04e-01 |
| KEGG | KEGG:04621 | NOD-like receptor signaling pathway | 43 | 109 | 3.16e-01 |
| KEGG | KEGG:00565 | Ether lipid metabolism | 13 | 28 | 3.19e-01 |
| KEGG | KEGG:04977 | Vitamin digestion and absorption | 7 | 13 | 3.19e-01 |
| KEGG | KEGG:00533 | Glycosaminoglycan biosynthesis - keratan sulfate | 7 | 13 | 3.19e-01 |
| KEGG | KEGG:04975 | Fat digestion and absorption | 9 | 18 | 3.27e-01 |
| KEGG | KEGG:05207 | Chemical carcinogenesis - receptor activation | 51 | 132 | 3.27e-01 |
| KEGG | KEGG:05170 | Human immunodeficiency virus 1 infection | 57 | 149 | 3.29e-01 |
| KEGG | KEGG:03271 | Virion - Rotavirus | 2 | 2 | 3.30e-01 |
| KEGG | KEGG:04935 | Growth hormone synthesis, secretion and action | 38 | 96 | 3.30e-01 |
| KEGG | KEGG:00524 | Neomycin, kanamycin and gentamicin biosynthesis | 3 | 4 | 3.30e-01 |
| KEGG | KEGG:03320 | PPAR signaling pathway | 20 | 47 | 3.35e-01 |
| KEGG | KEGG:00020 | Citrate cycle (TCA cycle) | 12 | 26 | 3.41e-01 |
| KEGG | KEGG:05132 | Salmonella infection | 75 | 201 | 3.41e-01 |
| KEGG | KEGG:00052 | Galactose metabolism | 10 | 21 | 3.44e-01 |
| KEGG | KEGG:00040 | Pentose and glucuronate interconversions | 6 | 11 | 3.44e-01 |
| KEGG | KEGG:00380 | Tryptophan metabolism | 10 | 21 | 3.44e-01 |
| KEGG | KEGG:05145 | Toxoplasmosis | 29 | 72 | 3.47e-01 |
| KEGG | KEGG:04973 | Carbohydrate digestion and absorption | 13 | 29 | 3.56e-01 |
| KEGG | KEGG:04710 | Circadian rhythm | 13 | 29 | 3.56e-01 |
| KEGG | KEGG:04114 | Oocyte meiosis | 40 | 103 | 3.59e-01 |
| KEGG | KEGG:00310 | Lysine degradation | 23 | 56 | 3.59e-01 |
| KEGG | KEGG:04148 | Efferocytosis | 46 | 120 | 3.59e-01 |
| KEGG | KEGG:05210 | Colorectal cancer | 32 | 81 | 3.62e-01 |
| KEGG | KEGG:04960 | Aldosterone-regulated sodium reabsorption | 11 | 24 | 3.62e-01 |
| KEGG | KEGG:04350 | TGF-beta signaling pathway | 35 | 90 | 3.89e-01 |
| KEGG | KEGG:05214 | Glioma | 26 | 65 | 3.89e-01 |
| KEGG | KEGG:04610 | Complement and coagulation cascades | 15 | 35 | 3.89e-01 |
| KEGG | KEGG:04659 | Th17 cell differentiation | 24 | 60 | 4.08e-01 |
| KEGG | KEGG:00510 | N-Glycan biosynthesis | 20 | 49 | 4.08e-01 |
| KEGG | KEGG:04625 | C-type lectin receptor signaling pathway | 29 | 74 | 4.08e-01 |
| KEGG | KEGG:01200 | Carbon metabolism | 34 | 88 | 4.08e-01 |
| KEGG | KEGG:05208 | Chemical carcinogenesis - reactive oxygen species | 64 | 173 | 4.08e-01 |
| KEGG | KEGG:00330 | Arginine and proline metabolism | 14 | 33 | 4.24e-01 |
| KEGG | KEGG:00591 | Linoleic acid metabolism | 4 | 7 | 4.24e-01 |
| KEGG | KEGG:04657 | IL-17 signaling pathway | 22 | 55 | 4.27e-01 |
| KEGG | KEGG:05017 | Spinocerebellar ataxia | 45 | 120 | 4.35e-01 |
| KEGG | KEGG:04750 | Inflammatory mediator regulation of TRP channels | 28 | 72 | 4.37e-01 |
| KEGG | KEGG:05020 | Prion disease | 74 | 204 | 4.45e-01 |
| KEGG | KEGG:00532 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | 9 | 20 | 4.45e-01 |
| KEGG | KEGG:03060 | Protein export | 12 | 28 | 4.45e-01 |
| KEGG | KEGG:04658 | Th1 and Th2 cell differentiation | 20 | 50 | 4.45e-01 |
| KEGG | KEGG:04152 | AMPK signaling pathway | 38 | 101 | 4.56e-01 |
| KEGG | KEGG:01100 | Metabolic pathways | 370 | 1077 | 4.56e-01 |
| KEGG | KEGG:04120 | Ubiquitin mediated proteolysis | 47 | 127 | 4.62e-01 |
| KEGG | KEGG:01040 | Biosynthesis of unsaturated fatty acids | 10 | 23 | 4.62e-01 |
| KEGG | KEGG:00592 | alpha-Linolenic acid metabolism | 5 | 10 | 4.66e-01 |
| KEGG | KEGG:04910 | Insulin signaling pathway | 42 | 113 | 4.66e-01 |
| KEGG | KEGG:00730 | Thiamine metabolism | 5 | 10 | 4.66e-01 |
| KEGG | KEGG:01250 | Biosynthesis of nucleotide sugars | 14 | 34 | 4.66e-01 |
| KEGG | KEGG:04714 | Thermogenesis | 67 | 185 | 4.66e-01 |
| KEGG | KEGG:05010 | Alzheimer disease | 105 | 296 | 4.66e-01 |
| KEGG | KEGG:05215 | Prostate cancer | 31 | 82 | 4.71e-01 |
| KEGG | KEGG:04962 | Vasopressin-regulated water reabsorption | 15 | 37 | 4.71e-01 |
| KEGG | KEGG:05022 | Pathways of neurodegeneration - multiple diseases | 128 | 364 | 4.71e-01 |
| KEGG | KEGG:00670 | One carbon pool by folate | 8 | 18 | 4.71e-01 |
| KEGG | KEGG:03015 | mRNA surveillance pathway | 30 | 80 | 5.07e-01 |
| KEGG | KEGG:04260 | Cardiac muscle contraction | 24 | 63 | 5.09e-01 |
| KEGG | KEGG:05012 | Parkinson disease | 75 | 211 | 5.26e-01 |
| KEGG | KEGG:04211 | Longevity regulating pathway | 28 | 75 | 5.30e-01 |
| KEGG | KEGG:05143 | African trypanosomiasis | 7 | 16 | 5.30e-01 |
| KEGG | KEGG:00780 | Biotin metabolism | 2 | 3 | 5.30e-01 |
| KEGG | KEGG:00430 | Taurine and hypotaurine metabolism | 4 | 8 | 5.30e-01 |
| KEGG | KEGG:00603 | Glycosphingolipid biosynthesis - globo and isoglobo series | 4 | 8 | 5.30e-01 |
| KEGG | KEGG:04976 | Bile secretion | 16 | 41 | 5.31e-01 |
| KEGG | KEGG:04218 | Cellular senescence | 49 | 136 | 5.34e-01 |
| KEGG | KEGG:00561 | Glycerolipid metabolism | 17 | 44 | 5.35e-01 |
| KEGG | KEGG:04622 | RIG-I-like receptor signaling pathway | 17 | 44 | 5.35e-01 |
| KEGG | KEGG:00534 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin | 8 | 19 | 5.47e-01 |
| KEGG | KEGG:03022 | Basal transcription factors | 13 | 33 | 5.51e-01 |
| KEGG | KEGG:05225 | Hepatocellular carcinoma | 49 | 137 | 5.60e-01 |
| KEGG | KEGG:00500 | Starch and sucrose metabolism | 9 | 22 | 5.60e-01 |
| KEGG | KEGG:00410 | beta-Alanine metabolism | 9 | 22 | 5.60e-01 |
| KEGG | KEGG:04932 | Non-alcoholic fatty liver disease | 45 | 126 | 5.74e-01 |
| KEGG | KEGG:01232 | Nucleotide metabolism | 24 | 65 | 5.74e-01 |
| KEGG | KEGG:04740 | Olfactory transduction | 10 | 25 | 5.74e-01 |
| KEGG | KEGG:04640 | Hematopoietic cell lineage | 11 | 28 | 5.78e-01 |
| KEGG | KEGG:05206 | MicroRNAs in cancer | 51 | 144 | 5.78e-01 |
| KEGG | KEGG:00250 | Alanine, aspartate and glutamate metabolism | 11 | 28 | 5.78e-01 |
| KEGG | KEGG:00511 | Other glycan degradation | 6 | 14 | 5.78e-01 |
| KEGG | KEGG:05032 | Morphine addiction | 20 | 54 | 5.86e-01 |
| KEGG | KEGG:05213 | Endometrial cancer | 20 | 54 | 5.86e-01 |
| KEGG | KEGG:00740 | Riboflavin metabolism | 3 | 6 | 5.86e-01 |
| KEGG | KEGG:04380 | Osteoclast differentiation | 33 | 92 | 5.96e-01 |
| KEGG | KEGG:05203 | Viral carcinogenesis | 50 | 142 | 6.00e-01 |
| KEGG | KEGG:04550 | Signaling pathways regulating pluripotency of stem cells | 36 | 101 | 6.01e-01 |
| KEGG | KEGG:05220 | Chronic myeloid leukemia | 26 | 72 | 6.09e-01 |
| KEGG | KEGG:04934 | Cushing syndrome | 42 | 119 | 6.12e-01 |
| KEGG | KEGG:00061 | Fatty acid biosynthesis | 4 | 9 | 6.20e-01 |
| KEGG | KEGG:04727 | GABAergic synapse | 19 | 52 | 6.20e-01 |
| KEGG | KEGG:01210 | 2-Oxocarboxylic acid metabolism | 10 | 26 | 6.20e-01 |
| KEGG | KEGG:05120 | Epithelial cell signaling in Helicobacter pylori infection | 20 | 55 | 6.23e-01 |
| KEGG | KEGG:04936 | Alcoholic liver disease | 32 | 91 | 6.51e-01 |
| KEGG | KEGG:04931 | Insulin resistance | 32 | 91 | 6.51e-01 |
| KEGG | KEGG:03082 | ATP-dependent chromatin remodeling | 32 | 91 | 6.51e-01 |
| KEGG | KEGG:04914 | Progesterone-mediated oocyte maturation | 29 | 82 | 6.51e-01 |
| KEGG | KEGG:01522 | Endocrine resistance | 29 | 82 | 6.51e-01 |
| KEGG | KEGG:04213 | Longevity regulating pathway - multiple species | 18 | 50 | 6.59e-01 |
| KEGG | KEGG:05016 | Huntington disease | 84 | 246 | 6.65e-01 |
| KEGG | KEGG:04540 | Gap junction | 25 | 71 | 6.69e-01 |
| KEGG | KEGG:05212 | Pancreatic cancer | 25 | 71 | 6.69e-01 |
| KEGG | KEGG:05235 | PD-L1 expression and PD-1 checkpoint pathway in cancer | 23 | 65 | 6.69e-01 |
| KEGG | KEGG:05216 | Thyroid cancer | 12 | 33 | 6.86e-01 |
| KEGG | KEGG:00600 | Sphingolipid metabolism | 15 | 42 | 6.96e-01 |
| KEGG | KEGG:04145 | Phagosome | 29 | 84 | 7.09e-01 |
| KEGG | KEGG:05223 | Non-small cell lung cancer | 22 | 64 | 7.09e-01 |
| KEGG | KEGG:00785 | Lipoic acid metabolism | 6 | 16 | 7.09e-01 |
| KEGG | KEGG:04390 | Hippo signaling pathway | 44 | 129 | 7.09e-01 |
| KEGG | KEGG:00340 | Histidine metabolism | 4 | 10 | 7.09e-01 |
| KEGG | KEGG:04814 | Motor proteins | 48 | 141 | 7.09e-01 |
| KEGG | KEGG:04721 | Synaptic vesicle cycle | 17 | 49 | 7.09e-01 |
| KEGG | KEGG:04060 | Cytokine-cytokine receptor interaction | 32 | 94 | 7.09e-01 |
| KEGG | KEGG:05033 | Nicotine addiction | 4 | 10 | 7.09e-01 |
| KEGG | KEGG:04137 | Mitophagy - animal | 32 | 94 | 7.09e-01 |
| KEGG | KEGG:04064 | NF-kappa B signaling pathway | 21 | 61 | 7.09e-01 |
| KEGG | KEGG:00920 | Sulfur metabolism | 4 | 10 | 7.09e-01 |
| KEGG | KEGG:00982 | Drug metabolism - cytochrome P450 | 6 | 16 | 7.09e-01 |
| KEGG | KEGG:04130 | SNARE interactions in vesicular transport | 11 | 31 | 7.09e-01 |
| KEGG | KEGG:01523 | Antifolate resistance | 8 | 22 | 7.09e-01 |
| KEGG | KEGG:00630 | Glyoxylate and dicarboxylate metabolism | 9 | 25 | 7.09e-01 |
| KEGG | KEGG:01521 | EGFR tyrosine kinase inhibitor resistance | 25 | 72 | 7.09e-01 |
| KEGG | KEGG:00590 | Arachidonic acid metabolism | 9 | 25 | 7.09e-01 |
| KEGG | KEGG:00620 | Pyruvate metabolism | 11 | 31 | 7.09e-01 |
| KEGG | KEGG:05167 | Kaposi sarcoma-associated herpesvirus infection | 45 | 134 | 7.40e-01 |
| KEGG | KEGG:04140 | Autophagy - animal | 50 | 149 | 7.40e-01 |
| KEGG | KEGG:05160 | Hepatitis C | 37 | 110 | 7.41e-01 |
| KEGG | KEGG:00240 | Pyrimidine metabolism | 15 | 44 | 7.49e-01 |
| KEGG | KEGG:00980 | Metabolism of xenobiotics by cytochrome P450 | 8 | 23 | 7.49e-01 |
| KEGG | KEGG:05144 | Malaria | 7 | 20 | 7.49e-01 |
| KEGG | KEGG:05030 | Cocaine addiction | 11 | 32 | 7.49e-01 |
| KEGG | KEGG:04913 | Ovarian steroidogenesis | 9 | 26 | 7.49e-01 |
| KEGG | KEGG:00260 | Glycine, serine and threonine metabolism | 9 | 26 | 7.49e-01 |
| KEGG | KEGG:04978 | Mineral absorption | 13 | 38 | 7.49e-01 |
| KEGG | KEGG:00563 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 8 | 23 | 7.49e-01 |
| KEGG | KEGG:00650 | Butanoate metabolism | 6 | 17 | 7.49e-01 |
| KEGG | KEGG:00450 | Selenocompound metabolism | 5 | 14 | 7.50e-01 |
| KEGG | KEGG:00120 | Primary bile acid biosynthesis | 4 | 11 | 7.52e-01 |
| KEGG | KEGG:04620 | Toll-like receptor signaling pathway | 20 | 60 | 7.56e-01 |
| KEGG | KEGG:05142 | Chagas disease | 24 | 72 | 7.56e-01 |
| KEGG | KEGG:03265 | Virion - Ebolavirus and Lyssavirus | 2 | 5 | 7.56e-01 |
| KEGG | KEGG:00053 | Ascorbate and aldarate metabolism | 3 | 8 | 7.56e-01 |
| KEGG | KEGG:00440 | Phosphonate and phosphinate metabolism | 2 | 5 | 7.56e-01 |
| KEGG | KEGG:04917 | Prolactin signaling pathway | 18 | 54 | 7.57e-01 |
| KEGG | KEGG:05133 | Pertussis | 14 | 42 | 7.66e-01 |
| KEGG | KEGG:03267 | Virion - Adenovirus | 1 | 2 | 7.72e-01 |
| KEGG | KEGG:03083 | Polycomb repressive complex | 23 | 70 | 7.84e-01 |
| KEGG | KEGG:02010 | ABC transporters | 8 | 24 | 7.86e-01 |
| KEGG | KEGG:05152 | Tuberculosis | 33 | 101 | 7.95e-01 |
| KEGG | KEGG:04613 | Neutrophil extracellular trap formation | 29 | 89 | 8.01e-01 |
| KEGG | KEGG:00100 | Steroid biosynthesis | 5 | 15 | 8.03e-01 |
| KEGG | KEGG:04668 | TNF signaling pathway | 27 | 83 | 8.03e-01 |
| KEGG | KEGG:00983 | Drug metabolism - other enzymes | 13 | 40 | 8.05e-01 |
| KEGG | KEGG:00564 | Glycerophospholipid metabolism | 23 | 71 | 8.07e-01 |
| KEGG | KEGG:05134 | Legionellosis | 11 | 34 | 8.08e-01 |
| KEGG | KEGG:04744 | Phototransduction | 4 | 12 | 8.08e-01 |
| KEGG | KEGG:00190 | Oxidative phosphorylation | 32 | 99 | 8.09e-01 |
| KEGG | KEGG:05218 | Melanoma | 18 | 56 | 8.15e-01 |
| KEGG | KEGG:00130 | Ubiquinone and other terpenoid-quinone biosynthesis | 3 | 9 | 8.20e-01 |
| KEGG | KEGG:04392 | Hippo signaling pathway - multiple species | 8 | 25 | 8.22e-01 |
| KEGG | KEGG:05171 | Coronavirus disease - COVID-19 | 48 | 149 | 8.22e-01 |
| KEGG | KEGG:04923 | Regulation of lipolysis in adipocytes | 13 | 41 | 8.26e-01 |
| KEGG | KEGG:05110 | Vibrio cholerae infection | 13 | 41 | 8.26e-01 |
| KEGG | KEGG:00010 | Glycolysis / Gluconeogenesis | 13 | 41 | 8.26e-01 |
| KEGG | KEGG:05162 | Measles | 27 | 85 | 8.37e-01 |
| KEGG | KEGG:00140 | Steroid hormone biosynthesis | 5 | 16 | 8.46e-01 |
| KEGG | KEGG:04150 | mTOR signaling pathway | 41 | 129 | 8.46e-01 |
| KEGG | KEGG:04080 | Neuroactive ligand-receptor interaction | 32 | 101 | 8.46e-01 |
| KEGG | KEGG:04215 | Apoptosis - multiple species | 9 | 29 | 8.46e-01 |
| KEGG | KEGG:03018 | RNA degradation | 21 | 67 | 8.48e-01 |
| KEGG | KEGG:05150 | Staphylococcus aureus infection | 4 | 13 | 8.53e-01 |
| KEGG | KEGG:04070 | Phosphatidylinositol signaling system | 26 | 83 | 8.55e-01 |
| KEGG | KEGG:00360 | Phenylalanine metabolism | 1 | 3 | 8.64e-01 |
| KEGG | KEGG:05320 | Autoimmune thyroid disease | 1 | 3 | 8.64e-01 |
| KEGG | KEGG:00290 | Valine, leucine and isoleucine biosynthesis | 1 | 3 | 8.64e-01 |
| KEGG | KEGG:04068 | FoxO signaling pathway | 33 | 106 | 8.64e-01 |
| KEGG | KEGG:00230 | Purine metabolism | 29 | 93 | 8.64e-01 |
| KEGG | KEGG:00030 | Pentose phosphate pathway | 6 | 20 | 8.64e-01 |
| KEGG | KEGG:05321 | Inflammatory bowel disease | 6 | 20 | 8.64e-01 |
| KEGG | KEGG:05204 | Chemical carcinogenesis - DNA adducts | 6 | 20 | 8.64e-01 |
| KEGG | KEGG:04146 | Peroxisome | 20 | 66 | 8.93e-01 |
| KEGG | KEGG:00601 | Glycosphingolipid biosynthesis - lacto and neolacto series | 4 | 14 | 8.95e-01 |
| KEGG | KEGG:05140 | Leishmaniasis | 11 | 38 | 9.19e-01 |
| KEGG | KEGG:00350 | Tyrosine metabolism | 3 | 11 | 9.19e-01 |
| KEGG | KEGG:04964 | Proximal tubule bicarbonate reclamation | 5 | 18 | 9.19e-01 |
| KEGG | KEGG:00760 | Nicotinate and nicotinamide metabolism | 8 | 28 | 9.19e-01 |
| KEGG | KEGG:05014 | Amyotrophic lateral sclerosis | 91 | 291 | 9.24e-01 |
| KEGG | KEGG:04623 | Cytosolic DNA-sensing pathway | 13 | 46 | 9.26e-01 |
| KEGG | KEGG:00770 | Pantothenate and CoA biosynthesis | 4 | 15 | 9.26e-01 |
| KEGG | KEGG:00470 | D-Amino acid metabolism | 1 | 4 | 9.26e-01 |
| KEGG | KEGG:00515 | Mannose type O-glycan biosynthesis | 5 | 19 | 9.26e-01 |
| KEGG | KEGG:05226 | Gastric cancer | 34 | 113 | 9.26e-01 |
| KEGG | KEGG:05166 | Human T-cell leukemia virus 1 infection | 50 | 164 | 9.26e-01 |
| KEGG | KEGG:04612 | Antigen processing and presentation | 7 | 26 | 9.26e-01 |
| KEGG | KEGG:05164 | Influenza A | 28 | 95 | 9.26e-01 |
| KEGG | KEGG:03040 | Spliceosome | 37 | 124 | 9.26e-01 |
| KEGG | KEGG:04950 | Maturity onset diabetes of the young | 1 | 4 | 9.26e-01 |
| KEGG | KEGG:04136 | Autophagy - other | 8 | 29 | 9.26e-01 |
| KEGG | KEGG:04061 | Viral protein interaction with cytokine and cytokine receptor | 5 | 19 | 9.26e-01 |
| KEGG | KEGG:00970 | Aminoacyl-tRNA biosynthesis | 12 | 42 | 9.26e-01 |
| KEGG | KEGG:00480 | Glutathione metabolism | 11 | 39 | 9.26e-01 |
| KEGG | KEGG:03020 | RNA polymerase | 9 | 33 | 9.29e-01 |
| KEGG | KEGG:03013 | Nucleocytoplasmic transport | 28 | 96 | 9.32e-01 |
| KEGG | KEGG:04210 | Apoptosis | 33 | 112 | 9.32e-01 |
| KEGG | KEGG:00562 | Inositol phosphate metabolism | 17 | 60 | 9.32e-01 |
| KEGG | KEGG:05202 | Transcriptional misregulation in cancer | 36 | 122 | 9.33e-01 |
| KEGG | KEGG:05161 | Hepatitis B | 37 | 126 | 9.43e-01 |
| KEGG | KEGG:05169 | Epstein-Barr virus infection | 40 | 136 | 9.46e-01 |
| KEGG | KEGG:03008 | Ribosome biogenesis in eukaryotes | 18 | 65 | 9.50e-01 |
| KEGG | KEGG:05323 | Rheumatoid arthritis | 10 | 38 | 9.50e-01 |
| KEGG | KEGG:04216 | Ferroptosis | 8 | 31 | 9.50e-01 |
| KEGG | KEGG:05221 | Acute myeloid leukemia | 14 | 52 | 9.56e-01 |
| KEGG | KEGG:00900 | Terpenoid backbone biosynthesis | 5 | 21 | 9.63e-01 |
| KEGG | KEGG:05224 | Breast cancer | 32 | 113 | 9.70e-01 |
| KEGG | KEGG:00790 | Folate biosynthesis | 4 | 18 | 9.73e-01 |
| KEGG | KEGG:03050 | Proteasome | 10 | 40 | 9.73e-01 |
| KEGG | KEGG:00860 | Porphyrin metabolism | 4 | 18 | 9.73e-01 |
| KEGG | KEGG:00830 | Retinol metabolism | 3 | 14 | 9.73e-01 |
| KEGG | KEGG:03250 | Viral life cycle - HIV-1 | 14 | 54 | 9.73e-01 |
| KEGG | KEGG:05034 | Alcoholism | 28 | 102 | 9.77e-01 |
| KEGG | KEGG:00270 | Cysteine and methionine metabolism | 9 | 37 | 9.77e-01 |
| KEGG | KEGG:01230 | Biosynthesis of amino acids | 13 | 52 | 9.80e-01 |
| KEGG | KEGG:04330 | Notch signaling pathway | 13 | 52 | 9.80e-01 |
| KEGG | KEGG:00220 | Arginine biosynthesis | 3 | 15 | 9.80e-01 |
| KEGG | KEGG:03440 | Homologous recombination | 9 | 38 | 9.81e-01 |
| KEGG | KEGG:03450 | Non-homologous end-joining | 2 | 12 | 9.93e-01 |
| KEGG | KEGG:01240 | Biosynthesis of cofactors | 29 | 109 | 9.93e-01 |
| KEGG | KEGG:03420 | Nucleotide excision repair | 13 | 54 | 9.93e-01 |
| KEGG | KEGG:04217 | Necroptosis | 25 | 99 | 9.96e-01 |
| KEGG | KEGG:01524 | Platinum drug resistance | 14 | 60 | 9.96e-01 |
| KEGG | KEGG:03430 | Mismatch repair | 4 | 22 | 9.96e-01 |
| KEGG | KEGG:04122 | Sulfur relay system | 1 | 8 | 9.96e-01 |
| KEGG | KEGG:05340 | Primary immunodeficiency | 1 | 8 | 9.96e-01 |
| KEGG | KEGG:00910 | Nitrogen metabolism | 1 | 8 | 9.96e-01 |
| KEGG | KEGG:03460 | Fanconi anemia pathway | 10 | 46 | 9.97e-01 |
| KEGG | KEGG:04966 | Collecting duct acid secretion | 2 | 18 | 1.00e+00 |
| KEGG | KEGG:05322 | Systemic lupus erythematosus | 5 | 44 | 1.00e+00 |
| KEGG | KEGG:04110 | Cell cycle | 38 | 146 | 1.00e+00 |
| KEGG | KEGG:05168 | Herpes simplex virus 1 infection | 80 | 388 | 1.00e+00 |
| KEGG | KEGG:04115 | p53 signaling pathway | 10 | 66 | 1.00e+00 |
| KEGG | KEGG:05217 | Basal cell carcinoma | 8 | 48 | 1.00e+00 |
| KEGG | KEGG:03010 | Ribosome | 27 | 121 | 1.00e+00 |
| KEGG | KEGG:04672 | Intestinal immune network for IgA production | 1 | 10 | 1.00e+00 |
| KEGG | KEGG:03030 | DNA replication | 4 | 34 | 1.00e+00 |
| KEGG | KEGG:03410 | Base excision repair | 4 | 44 | 1.00e+00 |
# intersect(unique(Resp_RNA$ENTREZID), unique(NR_peak_list_20k$ENTREZID)))
not_LR_int_restable %>%
filter(source=="GO:BP", p_value < 0.05) %>%
slice_head(n=10) %>%
mutate(log10_p=(-log(p_value, base=10))) %>%
ggplot(., aes(x=log10_p, y=reorder(term_name, log10_p)))+
geom_col(fill="#00BFC4")+
theme_bw()+
ylab("")+
xlab(paste0("-log10 p-value"))+
guides(fill="none")+
theme(axis.text.y = element_text(color="black"))+
ggtitle("not Intersection LR")
# library(clusterProfiler)
# genes_go = list("EAR"=int_EAR_n_RNAresp,"ESR"=int_ESR_n_RNAresp, "LR"=int_LR_n_RNAresp)
# names(genes) = sub("_", "\n", names(genes))
compEAR <- enrichGO(int_EAR_n_RNAresp,
universe = background_df$ENTREZID,
ont = "BP",
pvalueCutoff = 0.05,
OrgDb='org.Hs.eg.db',
pAdjustMethod = "BH")
# dotplot(compKEGG, showCategory = 15, title = "GO Enrichment Analysis")
compESR <- enrichGO(int_ESR_n_RNAresp,
universe = background_df$ENTREZID,
ont = "BP",
pvalueCutoff = 0.05,
OrgDb='org.Hs.eg.db',
pAdjustMethod = "BH")
# dotplot(compESR, showCategory = 15, title = "GO Enrichment Analysis")
compLR <- enrichGO(int_LR_n_RNAresp,
universe = background_df$ENTREZID,
ont = "BP",
pvalueCutoff = 0.05,
OrgDb='org.Hs.eg.db',
pAdjustMethod = "BH")
barplot(compLR,x="p.adjust", showCategory = 15, title = "GO Enrichment Analysis for LR")
| Version | Author | Date |
|---|---|---|
| eea0976 | reneeisnowhere | 2024-06-03 |
barplot(compEAR,x="p.adjust", showCategory = 15, title = "GO Enrichment Analysis for EAR")
| Version | Author | Date |
|---|---|---|
| eea0976 | reneeisnowhere | 2024-06-03 |
barplot(compESR,x="p.adjust", showCategory = 15, title = "GO Enrichment Analysis for ESR")
| Version | Author | Date |
|---|---|---|
| eea0976 | reneeisnowhere | 2024-06-03 |
# goplot(compLR)
compEARx <- setReadable(compEAR, 'org.Hs.eg.db', 'ENTREZID')
compESRx <- setReadable(compESR, 'org.Hs.eg.db', 'ENTREZID')
compLRx <- setReadable(compLR, 'org.Hs.eg.db', 'ENTREZID')cnetplot(compEARx)
| Version | Author | Date |
|---|---|---|
| eea0976 | reneeisnowhere | 2024-06-03 |
cnetplot(compESRx)
| Version | Author | Date |
|---|---|---|
| eea0976 | reneeisnowhere | 2024-06-03 |
cnetplot(compLRx, node_label="all")
| Version | Author | Date |
|---|---|---|
| eea0976 | reneeisnowhere | 2024-06-03 |
# upsetplot(compLRx)
sessionInfo()R version 4.3.1 (2023-06-16 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)
Matrix products: default
locale:
[1] LC_COLLATE=English_United States.utf8
[2] LC_CTYPE=English_United States.utf8
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C
[5] LC_TIME=English_United States.utf8
time zone: America/Chicago
tzcode source: internal
attached base packages:
[1] grid stats4 stats graphics grDevices utils datasets
[8] methods base
other attached packages:
[1] clusterProfiler_4.10.1
[2] biomaRt_2.58.2
[3] ggpubr_0.6.0
[4] BiocParallel_1.36.0
[5] scales_1.3.0
[6] VennDiagram_1.7.3
[7] futile.logger_1.4.3
[8] gridExtra_2.3
[9] ggfortify_0.4.17
[10] edgeR_4.0.16
[11] limma_3.58.1
[12] rtracklayer_1.62.0
[13] org.Hs.eg.db_3.18.0
[14] TxDb.Hsapiens.UCSC.hg38.knownGene_3.18.0
[15] GenomicFeatures_1.54.4
[16] AnnotationDbi_1.64.1
[17] Biobase_2.62.0
[18] GenomicRanges_1.54.1
[19] GenomeInfoDb_1.38.8
[20] IRanges_2.36.0
[21] S4Vectors_0.40.2
[22] BiocGenerics_0.48.1
[23] ChIPseeker_1.38.0
[24] gprofiler2_0.2.3
[25] RColorBrewer_1.1-3
[26] broom_1.0.6
[27] kableExtra_1.4.0
[28] lubridate_1.9.3
[29] forcats_1.0.0
[30] stringr_1.5.1
[31] dplyr_1.1.4
[32] purrr_1.0.2
[33] readr_2.1.5
[34] tidyr_1.3.1
[35] tibble_3.2.1
[36] ggplot2_3.5.1
[37] tidyverse_2.0.0
[38] workflowr_1.7.1
loaded via a namespace (and not attached):
[1] fs_1.6.4
[2] matrixStats_1.3.0
[3] bitops_1.0-7
[4] enrichplot_1.22.0
[5] HDO.db_0.99.1
[6] httr_1.4.7
[7] tools_4.3.1
[8] backports_1.5.0
[9] utf8_1.2.4
[10] R6_2.5.1
[11] lazyeval_0.2.2
[12] withr_3.0.0
[13] prettyunits_1.2.0
[14] cli_3.6.2
[15] formatR_1.14
[16] scatterpie_0.2.2
[17] labeling_0.4.3
[18] sass_0.4.9
[19] Rsamtools_2.18.0
[20] systemfonts_1.1.0
[21] yulab.utils_0.1.4
[22] gson_0.1.0
[23] DOSE_3.28.2
[24] svglite_2.1.3
[25] plotrix_3.8-4
[26] rstudioapi_0.16.0
[27] RSQLite_2.3.7
[28] generics_0.1.3
[29] gridGraphics_0.5-1
[30] TxDb.Hsapiens.UCSC.hg19.knownGene_3.2.2
[31] BiocIO_1.12.0
[32] crosstalk_1.2.1
[33] vroom_1.6.5
[34] gtools_3.9.5
[35] car_3.1-2
[36] GO.db_3.18.0
[37] Matrix_1.6-5
[38] fansi_1.0.6
[39] abind_1.4-5
[40] lifecycle_1.0.4
[41] whisker_0.4.1
[42] yaml_2.3.8
[43] carData_3.0-5
[44] SummarizedExperiment_1.32.0
[45] gplots_3.1.3.1
[46] qvalue_2.34.0
[47] SparseArray_1.2.4
[48] BiocFileCache_2.10.2
[49] blob_1.2.4
[50] promises_1.3.0
[51] crayon_1.5.2
[52] lattice_0.22-6
[53] cowplot_1.1.3
[54] KEGGREST_1.42.0
[55] pillar_1.9.0
[56] knitr_1.47
[57] fgsea_1.28.0
[58] rjson_0.2.21
[59] boot_1.3-30
[60] codetools_0.2-20
[61] fastmatch_1.1-4
[62] glue_1.7.0
[63] getPass_0.2-4
[64] ggfun_0.1.5
[65] data.table_1.15.4
[66] vctrs_0.6.5
[67] png_0.1-8
[68] treeio_1.26.0
[69] gtable_0.3.5
[70] cachem_1.1.0
[71] xfun_0.44
[72] S4Arrays_1.2.1
[73] mime_0.12
[74] tidygraph_1.3.1
[75] statmod_1.5.0
[76] interactiveDisplayBase_1.40.0
[77] nlme_3.1-164
[78] ggtree_3.10.1
[79] bit64_4.0.5
[80] progress_1.2.3
[81] filelock_1.0.3
[82] rprojroot_2.0.4
[83] bslib_0.7.0
[84] KernSmooth_2.23-24
[85] colorspace_2.1-0
[86] DBI_1.2.3
[87] tidyselect_1.2.1
[88] processx_3.8.4
[89] bit_4.0.5
[90] compiler_4.3.1
[91] curl_5.2.1
[92] git2r_0.33.0
[93] xml2_1.3.6
[94] DelayedArray_0.28.0
[95] plotly_4.10.4
[96] shadowtext_0.1.3
[97] caTools_1.18.2
[98] callr_3.7.6
[99] rappdirs_0.3.3
[100] digest_0.6.35
[101] rmarkdown_2.27
[102] XVector_0.42.0
[103] htmltools_0.5.8.1
[104] pkgconfig_2.0.3
[105] MatrixGenerics_1.14.0
[106] highr_0.11
[107] dbplyr_2.5.0
[108] fastmap_1.2.0
[109] rlang_1.1.3
[110] htmlwidgets_1.6.4
[111] shiny_1.8.1.1
[112] farver_2.1.2
[113] jquerylib_0.1.4
[114] jsonlite_1.8.8
[115] GOSemSim_2.28.1
[116] RCurl_1.98-1.14
[117] magrittr_2.0.3
[118] GenomeInfoDbData_1.2.11
[119] ggplotify_0.1.2
[120] patchwork_1.2.0
[121] munsell_0.5.1
[122] Rcpp_1.0.12
[123] ape_5.8
[124] viridis_0.6.5
[125] stringi_1.8.4
[126] ggraph_2.2.1
[127] zlibbioc_1.48.2
[128] MASS_7.3-60.0.1
[129] AnnotationHub_3.10.1
[130] plyr_1.8.9
[131] parallel_4.3.1
[132] ggrepel_0.9.5
[133] Biostrings_2.70.3
[134] graphlayouts_1.1.1
[135] splines_4.3.1
[136] hms_1.1.3
[137] locfit_1.5-9.9
[138] ps_1.7.6
[139] igraph_2.0.3
[140] ggsignif_0.6.4
[141] reshape2_1.4.4
[142] futile.options_1.0.1
[143] BiocVersion_3.18.1
[144] XML_3.99-0.16.1
[145] evaluate_0.23
[146] lambda.r_1.2.4
[147] BiocManager_1.30.23
[148] tzdb_0.4.0
[149] tweenr_2.0.3
[150] httpuv_1.6.15
[151] polyclip_1.10-6
[152] ggforce_0.4.2
[153] xtable_1.8-4
[154] restfulr_0.0.15
[155] tidytree_0.4.6
[156] rstatix_0.7.2
[157] later_1.3.2
[158] viridisLite_0.4.2
[159] aplot_0.2.2
[160] memoise_2.0.1
[161] GenomicAlignments_1.38.2
[162] timechange_0.3.0