GO and KEGG pathway analysis

Last updated: 2024-05-03

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Knit directory: ATAC_learning/

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Unstaged changes:
    Modified:   analysis/CorMotif_data_n45.Rmd
    Modified:   analysis/Enrichment_motif.Rmd
    Modified:   analysis/Peak_analysis.Rmd
    Modified:   analysis/Smaller_set_DAR.Rmd
    Modified:   analysis/index.Rmd

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These are the previous versions of the repository in which changes were made to the R Markdown (analysis/GO_KEGG_analysis.Rmd) and HTML (docs/GO_KEGG_analysis.html) files. If you’ve configured a remote Git repository (see ?wflow_git_remote), click on the hyperlinks in the table below to view the files as they were in that past version.

File	Version	Author	Date	Message
Rmd	f57f2ee	reneeisnowhere	2024-05-03	first update

library(tidyverse)
# library(ggsignif)
# library(cowplot)
# library(ggpubr)

# library(sjmisc)
library(kableExtra)
library(broom)
# library(biomaRt)
library(RColorBrewer)
library(gprofiler2)
# library(qvalue)
library(ChIPseeker)
library("TxDb.Hsapiens.UCSC.hg38.knownGene")
library("org.Hs.eg.db")
# library(ATACseqQC)
library(rtracklayer)
library(edgeR)
library(ggfortify)
library(limma)
library(readr)
library(BiocGenerics)
library(gridExtra)
library(VennDiagram)
library(scales)
# library(ggVennDiagram)
# library(Cormotif)
library(BiocParallel)
library(ggpubr)
# library(devtools)
# # install_github('davetang/bedr')
# library(bedr)
library(biomaRt)

data loading

peakAnnoList_n45_motif <- readRDS("data/peakAnnoList_n45_motif.RDS")
# list2env(peakAnnoList_n45_motif, envir = .GlobalEnv)

EAR_df <- as.data.frame(peakAnnoList_n45_motif$EAR_n45_gr)
EAR_df_gr <-  GRanges(EAR_df)

ESR_df <- as.data.frame(peakAnnoList_n45_motif$ESR_n45_gr)
ESR_df_gr <-  GRanges(ESR_df)
 
LR_df <- as.data.frame(peakAnnoList_n45_motif$LR_n45_gr)
LR_df_gr <-  GRanges(LR_df)
 
NR_df <- as.data.frame(peakAnnoList_n45_motif$NR_n45_gr)
NR_df_gr <-  GRanges(NR_df)


exp_neargene_table <- read_delim("data/n45_bedfiles/exp_neargene_table.tsv", 
    delim = "\t", escape_double = FALSE, 
    trim_ws = TRUE)

# col_ng_peak <- exp_neargene_table %>%
#   group_by(chr, start, end, peakid) %>%
#     summarise(NCBI_gene = paste(unique(ENTREZID),collapse=","),
#               ensembl_ID= paste(unique(ensembl_id),collapse = ","),
#               SYMBOL= paste(unique(SYMBOL),collapse = ",") , 
#               dist_to_NG =min(dist_to_NG))
# 

EAR_NG_list <- exp_neargene_table %>% 
    dplyr::filter(peakid %in% EAR_df$id) %>% 
  dplyr::select(ENTREZID) %>% 
  distinct()

ESR_NG_list <- exp_neargene_table %>% 
    dplyr::filter(peakid %in% ESR_df$id) %>% 
  dplyr::select(ENTREZID) %>% 
  distinct()

LR_NG_list <- exp_neargene_table %>% 
    dplyr::filter(peakid %in% LR_df$id) %>% 
  dplyr::select(ENTREZID) %>% 
  distinct()

NR_NG_list <- exp_neargene_table %>% 
    dplyr::filter(peakid %in% NR_df$id) %>% 
  dplyr::select(ENTREZID) %>% 
  distinct()

background_df <- exp_neargene_table %>% 
  dplyr::select(ENTREZID) %>% 
  distinct()

EAR_resgenes <- readRDS("data/GO_KEGG_analysis/EAR_resgenes.RDS")
ESR_resgenes <- readRDS("data/GO_KEGG_analysis/ESR_resgenes.RDS")
LR_resgenes <- readRDS("data/GO_KEGG_analysis/LR_resgenes.RDS")
NR_resgenes <- readRDS("data/GO_KEGG_analysis/NR_resgenes.RDS")

EAR response genes

# EAR_resgenes <- gost(query = EAR_NG_list$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(EAR_resgenes,"data/GO_KEGG_analysis/EAR_resgenes.RDS")


EARnom <- gostplot(EAR_resgenes, capped = FALSE, interactive = TRUE)
# EARnom

EARnomtable <- EAR_resgenes$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

EARnomtable %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in EAR neargenes" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in EAR neargenes
source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0009653	anatomical structure morphogenesis	898	1844	4.11e-28
GO:BP	GO:0032502	developmental process	1806	4179	6.83e-26
GO:BP	GO:0048856	anatomical structure development	1683	3867	2.86e-25
GO:BP	GO:0007275	multicellular organism development	1413	3170	3.48e-25
GO:BP	GO:0032501	multicellular organismal process	1918	4504	2.88e-24
GO:BP	GO:0048869	cellular developmental process	1262	2804	8.92e-24
GO:BP	GO:0030154	cell differentiation	1261	2803	1.02e-23
GO:BP	GO:0050793	regulation of developmental process	809	1697	7.18e-22
GO:BP	GO:0048731	system development	1211	2719	1.94e-20
GO:BP	GO:0016477	cell migration	515	1011	3.91e-20
GO:BP	GO:0051239	regulation of multicellular organismal process	890	1924	1.81e-19
GO:BP	GO:0007154	cell communication	1686	3983	1.59e-18
GO:BP	GO:0023052	signaling	1660	3918	2.46e-18
GO:BP	GO:0048699	generation of neurons	535	1076	3.58e-18
GO:BP	GO:0040012	regulation of locomotion	380	720	1.16e-17
GO:BP	GO:0030334	regulation of cell migration	357	668	1.16e-17
GO:BP	GO:2000145	regulation of cell motility	371	700	1.19e-17
GO:BP	GO:0048870	cell motility	549	1120	4.10e-17
GO:BP	GO:0009887	animal organ morphogenesis	357	673	4.96e-17
GO:BP	GO:0007165	signal transduction	1534	3611	5.22e-17
GO:BP	GO:0022008	neurogenesis	602	1251	8.71e-17
GO:BP	GO:0040011	locomotion	413	805	1.25e-16
GO:BP	GO:0072359	circulatory system development	438	864	1.52e-16
GO:BP	GO:0030182	neuron differentiation	500	1014	4.14e-16
GO:BP	GO:0048513	animal organ development	901	2004	1.36e-15
GO:BP	GO:0050789	regulation of biological process	2957	7516	2.09e-15
GO:BP	GO:0009888	tissue development	634	1348	4.41e-15
GO:BP	GO:2000026	regulation of multicellular organismal development	469	951	4.83e-15
GO:BP	GO:0051094	positive regulation of developmental process	452	913	8.19e-15
GO:BP	GO:0050794	regulation of cellular process	2823	7153	8.19e-15
GO:BP	GO:0065007	biological regulation	3028	7734	1.41e-14
GO:BP	GO:0045595	regulation of cell differentiation	517	1073	2.39e-14
GO:BP	GO:0051716	cellular response to stimulus	1900	4640	4.73e-14
GO:BP	GO:0048468	cell development	845	1886	4.95e-14
GO:BP	GO:0048519	negative regulation of biological process	1571	3764	4.95e-14
GO:BP	GO:0007155	cell adhesion	460	941	5.94e-14
GO:BP	GO:0007399	nervous system development	800	1775	6.41e-14
GO:BP	GO:0009790	embryo development	409	821	6.86e-14
GO:BP	GO:0050896	response to stimulus	2170	5379	1.18e-13
GO:BP	GO:0048523	negative regulation of cellular process	1486	3550	1.59e-13
GO:BP	GO:0035239	tube morphogenesis	328	638	3.14e-13
GO:BP	GO:0048518	positive regulation of biological process	1766	4301	3.91e-13
GO:BP	GO:0035295	tube development	391	787	5.10e-13
GO:BP	GO:0034330	cell junction organization	286	545	7.88e-13
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	411	837	9.46e-13
GO:BP	GO:0007423	sensory organ development	215	387	1.12e-12
GO:BP	GO:0048522	positive regulation of cellular process	1631	3954	1.57e-12
GO:BP	GO:0010646	regulation of cell communication	1054	2444	1.80e-12
GO:BP	GO:0048666	neuron development	408	838	5.95e-12
GO:BP	GO:0003008	system process	532	1139	7.86e-12
GO:BP	GO:0023051	regulation of signaling	1047	2438	8.93e-12
GO:BP	GO:0045597	positive regulation of cell differentiation	302	591	9.93e-12
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	309	609	1.58e-11
GO:BP	GO:0031175	neuron projection development	366	743	1.67e-11
GO:BP	GO:0035556	intracellular signal transduction	854	1951	2.38e-11
GO:BP	GO:0009966	regulation of signal transduction	938	2166	2.52e-11
GO:BP	GO:0048598	embryonic morphogenesis	226	422	3.57e-11
GO:BP	GO:0141124	intracellular signaling cassette	599	1314	4.36e-11
GO:BP	GO:0000902	cell morphogenesis	351	713	5.76e-11
GO:BP	GO:0001501	skeletal system development	191	347	9.68e-11
GO:BP	GO:0001944	vasculature development	280	552	2.24e-10
GO:BP	GO:0051093	negative regulation of developmental process	310	622	2.24e-10
GO:BP	GO:0030900	forebrain development	155	272	3.85e-10
GO:BP	GO:0001568	blood vessel development	267	525	5.12e-10
GO:BP	GO:0031344	regulation of cell projection organization	262	516	1.02e-09
GO:BP	GO:0065008	regulation of biological quality	820	1893	1.15e-09
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	257	505	1.15e-09
GO:BP	GO:0007166	cell surface receptor signaling pathway	784	1801	1.15e-09
GO:BP	GO:0010975	regulation of neuron projection development	191	355	1.34e-09
GO:BP	GO:0060429	epithelium development	377	792	2.17e-09
GO:BP	GO:0007507	heart development	253	499	2.66e-09
GO:BP	GO:0048514	blood vessel morphogenesis	231	450	4.42e-09
GO:BP	GO:0007267	cell-cell signaling	494	1082	4.64e-09
GO:BP	GO:0007417	central nervous system development	334	694	6.43e-09
GO:BP	GO:0048589	developmental growth	252	501	7.88e-09
GO:BP	GO:0051128	regulation of cellular component organization	802	1862	7.88e-09
GO:BP	GO:0048729	tissue morphogenesis	231	453	9.50e-09
GO:BP	GO:0051240	positive regulation of multicellular organismal process	475	1040	1.03e-08
GO:BP	GO:0048812	neuron projection morphogenesis	242	479	1.06e-08
GO:BP	GO:0030155	regulation of cell adhesion	254	508	1.35e-08
GO:BP	GO:0001503	ossification	164	302	1.35e-08
GO:BP	GO:0048583	regulation of response to stimulus	1130	2717	1.35e-08
GO:BP	GO:0071495	cellular response to endogenous stimulus	472	1035	1.47e-08
GO:BP	GO:0034329	cell junction assembly	173	323	1.74e-08
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	247	494	2.33e-08
GO:BP	GO:0009967	positive regulation of signal transduction	494	1093	2.57e-08
GO:BP	GO:0030030	cell projection organization	529	1182	3.41e-08
GO:BP	GO:0048858	cell projection morphogenesis	248	498	3.42e-08
GO:BP	GO:0014706	striated muscle tissue development	122	213	3.92e-08
GO:BP	GO:0045596	negative regulation of cell differentiation	228	452	4.03e-08
GO:BP	GO:0060322	head development	265	539	4.21e-08
GO:BP	GO:0070848	response to growth factor	268	547	5.16e-08
GO:BP	GO:0048738	cardiac muscle tissue development	116	201	5.44e-08
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	220	435	5.88e-08
GO:BP	GO:0010647	positive regulation of cell communication	541	1218	7.89e-08
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	338	717	8.14e-08
GO:BP	GO:0023056	positive regulation of signaling	542	1221	8.33e-08
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	513	1150	1.06e-07
GO:BP	GO:0071363	cellular response to growth factor stimulus	258	528	1.43e-07
GO:BP	GO:0007420	brain development	245	498	1.69e-07
GO:BP	GO:0061061	muscle structure development	261	536	1.72e-07
GO:BP	GO:0043583	ear development	91	151	1.85e-07
GO:BP	GO:0048880	sensory system development	144	266	1.96e-07
GO:BP	GO:0032989	cellular anatomical entity morphogenesis	282	588	2.55e-07
GO:BP	GO:0090596	sensory organ morphogenesis	101	173	2.72e-07
GO:BP	GO:0001525	angiogenesis	194	381	2.81e-07
GO:BP	GO:0001654	eye development	142	263	3.07e-07
GO:BP	GO:0030336	negative regulation of cell migration	118	210	3.07e-07
GO:BP	GO:2000146	negative regulation of cell motility	121	217	3.59e-07
GO:BP	GO:0150063	visual system development	142	264	4.21e-07
GO:BP	GO:0002062	chondrocyte differentiation	59	88	4.53e-07
GO:BP	GO:0001667	ameboidal-type cell migration	177	344	4.89e-07
GO:BP	GO:0060284	regulation of cell development	273	570	5.02e-07
GO:BP	GO:0051216	cartilage development	87	145	5.09e-07
GO:BP	GO:0009719	response to endogenous stimulus	527	1197	5.36e-07
GO:BP	GO:0010631	epithelial cell migration	132	243	6.17e-07
GO:BP	GO:0090132	epithelium migration	132	243	6.17e-07
GO:BP	GO:0098609	cell-cell adhesion	270	564	6.20e-07
GO:BP	GO:0040007	growth	325	697	6.25e-07
GO:BP	GO:0001764	neuron migration	79	129	6.61e-07
GO:BP	GO:0060537	muscle tissue development	174	339	7.73e-07
GO:BP	GO:0050808	synapse organization	173	337	8.34e-07
GO:BP	GO:0003013	circulatory system process	211	426	9.64e-07
GO:BP	GO:0008283	cell population proliferation	568	1306	1.06e-06
GO:BP	GO:0042221	response to chemical	955	2304	1.08e-06
GO:BP	GO:0040013	negative regulation of locomotion	131	243	1.22e-06
GO:BP	GO:0002009	morphogenesis of an epithelium	186	369	1.35e-06
GO:BP	GO:0007409	axonogenesis	172	337	1.51e-06
GO:BP	GO:1902531	regulation of intracellular signal transduction	560	1289	1.56e-06
GO:BP	GO:0048839	inner ear development	80	133	1.56e-06
GO:BP	GO:0061564	axon development	187	372	1.56e-06
GO:BP	GO:0060021	roof of mouth development	48	69	1.71e-06
GO:BP	GO:0051241	negative regulation of multicellular organismal process	326	706	1.89e-06
GO:BP	GO:0090130	tissue migration	132	247	2.04e-06
GO:BP	GO:0016358	dendrite development	103	183	2.18e-06
GO:BP	GO:0010632	regulation of epithelial cell migration	105	188	2.76e-06
GO:BP	GO:2000147	positive regulation of cell motility	201	408	3.29e-06
GO:BP	GO:0040017	positive regulation of locomotion	204	416	4.07e-06
GO:BP	GO:0030335	positive regulation of cell migration	195	395	4.26e-06
GO:BP	GO:0030029	actin filament-based process	297	640	4.36e-06
GO:BP	GO:0044057	regulation of system process	190	384	5.04e-06
GO:BP	GO:0048568	embryonic organ development	155	303	5.70e-06
GO:BP	GO:0042127	regulation of cell population proliferation	472	1077	6.07e-06
GO:BP	GO:0048732	gland development	157	308	6.25e-06
GO:BP	GO:0003007	heart morphogenesis	117	218	8.62e-06
GO:BP	GO:0061448	connective tissue development	111	205	9.75e-06
GO:BP	GO:0048705	skeletal system morphogenesis	85	148	9.75e-06
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	219	456	1.01e-05
GO:BP	GO:0016055	Wnt signaling pathway	177	358	1.44e-05
GO:BP	GO:0007389	pattern specification process	146	286	1.52e-05
GO:BP	GO:0043408	regulation of MAPK cascade	206	427	1.53e-05
GO:BP	GO:0070887	cellular response to chemical stimulus	732	1751	1.58e-05
GO:BP	GO:0198738	cell-cell signaling by wnt	177	359	1.79e-05
GO:BP	GO:0007264	small GTPase-mediated signal transduction	190	390	1.90e-05
GO:BP	GO:0060411	cardiac septum morphogenesis	45	67	2.05e-05
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	985	2415	2.05e-05
GO:BP	GO:0043010	camera-type eye development	121	230	2.05e-05
GO:BP	GO:0007411	axon guidance	95	172	2.13e-05
GO:BP	GO:0097485	neuron projection guidance	95	172	2.13e-05
GO:BP	GO:0048584	positive regulation of response to stimulus	635	1504	2.24e-05
GO:BP	GO:0060560	developmental growth involved in morphogenesis	103	190	2.32e-05
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	897	2186	2.42e-05
GO:BP	GO:0010033	response to organic substance	724	1736	2.71e-05
GO:BP	GO:0021537	telencephalon development	105	195	2.73e-05
GO:BP	GO:0030111	regulation of Wnt signaling pathway	134	261	2.87e-05
GO:BP	GO:0050807	regulation of synapse organization	95	173	2.92e-05
GO:BP	GO:0009952	anterior/posterior pattern specification	71	121	2.99e-05
GO:BP	GO:0051146	striated muscle cell differentiation	122	234	3.23e-05
GO:BP	GO:0016043	cellular component organization	1874	4802	3.24e-05
GO:BP	GO:0050803	regulation of synapse structure or activity	96	176	3.77e-05
GO:BP	GO:0001649	osteoblast differentiation	95	174	4.04e-05
GO:BP	GO:0009987	cellular process	3975	10686	4.12e-05
GO:BP	GO:0042692	muscle cell differentiation	160	323	4.12e-05
GO:BP	GO:0050877	nervous system process	275	600	4.21e-05
GO:BP	GO:0031589	cell-substrate adhesion	132	258	4.23e-05
GO:BP	GO:0048588	developmental cell growth	97	179	4.75e-05
GO:BP	GO:0034762	regulation of transmembrane transport	149	298	4.85e-05
GO:BP	GO:0008015	blood circulation	174	357	5.05e-05
GO:BP	GO:0050890	cognition	112	213	5.11e-05
GO:BP	GO:0000165	MAPK cascade	235	504	5.53e-05
GO:BP	GO:0045785	positive regulation of cell adhesion	150	301	5.61e-05
GO:BP	GO:0035265	organ growth	73	127	5.74e-05
GO:BP	GO:0071840	cellular component organization or biogenesis	1939	4988	5.76e-05
GO:BP	GO:0099536	synaptic signaling	226	483	6.35e-05
GO:BP	GO:0035313	wound healing, spreading of epidermal cells	16	17	6.38e-05
GO:BP	GO:0006468	protein phosphorylation	417	958	7.02e-05
GO:BP	GO:0009893	positive regulation of metabolic process	1057	2622	7.62e-05
GO:BP	GO:0045664	regulation of neuron differentiation	74	130	7.84e-05
GO:BP	GO:0045444	fat cell differentiation	96	179	9.34e-05
GO:BP	GO:0010648	negative regulation of cell communication	446	1034	9.54e-05
GO:BP	GO:0048592	eye morphogenesis	63	107	9.78e-05
GO:BP	GO:0051960	regulation of nervous system development	165	339	9.94e-05
GO:BP	GO:0048638	regulation of developmental growth	124	243	9.94e-05
GO:BP	GO:0051130	positive regulation of cellular component organization	373	850	1.00e-04
GO:BP	GO:0008285	negative regulation of cell population proliferation	219	469	1.06e-04
GO:BP	GO:0048762	mesenchymal cell differentiation	105	200	1.12e-04
GO:BP	GO:0031401	positive regulation of protein modification process	252	550	1.14e-04
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	382	874	1.18e-04
GO:BP	GO:0071310	cellular response to organic substance	548	1297	1.20e-04
GO:BP	GO:0009792	embryo development ending in birth or egg hatching	240	521	1.20e-04
GO:BP	GO:0072001	renal system development	124	244	1.25e-04
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	119	233	1.44e-04
GO:BP	GO:0023057	negative regulation of signaling	445	1036	1.58e-04
GO:BP	GO:0035051	cardiocyte differentiation	74	132	1.58e-04
GO:BP	GO:0030855	epithelial cell differentiation	201	428	1.66e-04
GO:BP	GO:0099537	trans-synaptic signaling	217	467	1.71e-04
GO:BP	GO:0099177	regulation of trans-synaptic signaling	157	323	1.82e-04
GO:BP	GO:0044087	regulation of cellular component biogenesis	334	757	1.87e-04
GO:BP	GO:0010720	positive regulation of cell development	151	309	1.89e-04
GO:BP	GO:0060412	ventricular septum morphogenesis	29	40	1.92e-04
GO:BP	GO:0045637	regulation of myeloid cell differentiation	75	135	2.07e-04
GO:BP	GO:0050673	epithelial cell proliferation	147	300	2.07e-04
GO:BP	GO:0031346	positive regulation of cell projection organization	141	286	2.13e-04
GO:BP	GO:0003002	regionalization	129	258	2.19e-04
GO:BP	GO:0055007	cardiac muscle cell differentiation	61	105	2.32e-04
GO:BP	GO:0010810	regulation of cell-substrate adhesion	87	162	2.32e-04
GO:BP	GO:0050804	modulation of chemical synaptic transmission	156	322	2.36e-04
GO:BP	GO:0045165	cell fate commitment	82	151	2.42e-04
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	105	203	2.45e-04
GO:BP	GO:0007369	gastrulation	77	140	2.47e-04
GO:BP	GO:0050770	regulation of axonogenesis	70	125	2.83e-04
GO:BP	GO:0043009	chordate embryonic development	232	507	2.89e-04
GO:BP	GO:0051049	regulation of transport	467	1098	2.89e-04
GO:BP	GO:1903706	regulation of hemopoiesis	128	257	2.92e-04
GO:BP	GO:0035107	appendage morphogenesis	63	110	2.96e-04
GO:BP	GO:0035108	limb morphogenesis	63	110	2.96e-04
GO:BP	GO:0050767	regulation of neurogenesis	142	290	2.96e-04
GO:BP	GO:0003206	cardiac chamber morphogenesis	63	110	2.96e-04
GO:BP	GO:0042592	homeostatic process	482	1137	3.01e-04
GO:BP	GO:0022612	gland morphogenesis	55	93	3.04e-04
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	124	248	3.09e-04
GO:BP	GO:0043410	positive regulation of MAPK cascade	141	288	3.14e-04
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	315	714	3.22e-04
GO:BP	GO:0007610	behavior	196	420	3.22e-04
GO:BP	GO:0002063	chondrocyte development	19	23	3.51e-04
GO:BP	GO:0008150	biological_process	4156	11244	3.65e-04
GO:BP	GO:0016049	cell growth	180	382	3.65e-04
GO:BP	GO:0065009	regulation of molecular function	544	1299	3.81e-04
GO:BP	GO:0048562	embryonic organ morphogenesis	95	182	3.84e-04
GO:BP	GO:0099175	regulation of postsynapse organization	49	81	3.87e-04
GO:BP	GO:0030036	actin cytoskeleton organization	255	566	3.90e-04
GO:BP	GO:0007611	learning or memory	98	189	3.97e-04
GO:BP	GO:0002761	regulation of myeloid leukocyte differentiation	48	79	3.98e-04
GO:BP	GO:0045667	regulation of osteoblast differentiation	57	98	4.00e-04
GO:BP	GO:0007268	chemical synaptic transmission	213	463	4.07e-04
GO:BP	GO:0098916	anterograde trans-synaptic signaling	213	463	4.07e-04
GO:BP	GO:0048813	dendrite morphogenesis	63	111	4.09e-04
GO:BP	GO:0030097	hemopoiesis	278	624	4.34e-04
GO:BP	GO:0003281	ventricular septum development	43	69	4.57e-04
GO:BP	GO:0010633	negative regulation of epithelial cell migration	34	51	4.71e-04
GO:BP	GO:0031325	positive regulation of cellular metabolic process	938	2333	4.73e-04
GO:BP	GO:0060041	retina development in camera-type eye	60	105	4.89e-04
GO:BP	GO:0099173	postsynapse organization	79	147	5.18e-04
GO:BP	GO:0060173	limb development	74	136	5.42e-04
GO:BP	GO:0048736	appendage development	74	136	5.42e-04
GO:BP	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	69	125	5.53e-04
GO:BP	GO:0021953	central nervous system neuron differentiation	57	99	5.80e-04
GO:BP	GO:0001822	kidney development	118	237	5.92e-04
GO:BP	GO:0022604	regulation of cell morphogenesis	99	193	6.04e-04
GO:BP	GO:2001222	regulation of neuron migration	27	38	6.25e-04
GO:BP	GO:0060070	canonical Wnt signaling pathway	120	242	6.32e-04
GO:BP	GO:0070372	regulation of ERK1 and ERK2 cascade	91	175	6.56e-04
GO:BP	GO:0008360	regulation of cell shape	60	106	7.00e-04
GO:BP	GO:0060348	bone development	78	146	7.47e-04
GO:BP	GO:0050772	positive regulation of axonogenesis	40	64	7.85e-04
GO:BP	GO:0003279	cardiac septum development	58	102	7.85e-04
GO:BP	GO:0055017	cardiac muscle tissue growth	40	64	7.85e-04
GO:BP	GO:0021543	pallium development	73	135	7.85e-04
GO:BP	GO:0035113	embryonic appendage morphogenesis	51	87	7.88e-04
GO:BP	GO:0030326	embryonic limb morphogenesis	51	87	7.88e-04
GO:BP	GO:0006811	monoatomic ion transport	314	719	7.89e-04
GO:BP	GO:0016310	phosphorylation	481	1145	8.12e-04
GO:BP	GO:0048645	animal organ formation	34	52	8.12e-04
GO:BP	GO:0003205	cardiac chamber development	80	151	8.43e-04
GO:BP	GO:0032879	regulation of localization	594	1439	9.38e-04
GO:BP	GO:0009968	negative regulation of signal transduction	413	972	9.46e-04
GO:BP	GO:0032924	activin receptor signaling pathway	24	33	9.46e-04
GO:BP	GO:0042476	odontogenesis	47	79	9.46e-04
GO:BP	GO:1901888	regulation of cell junction assembly	82	156	9.60e-04
GO:BP	GO:0031399	regulation of protein modification process	389	911	9.67e-04
GO:BP	GO:0002521	leukocyte differentiation	173	371	9.70e-04
GO:BP	GO:0030198	extracellular matrix organization	111	223	9.80e-04
GO:BP	GO:0050678	regulation of epithelial cell proliferation	122	249	1.01e-03
GO:BP	GO:0007416	synapse assembly	73	136	1.03e-03
GO:BP	GO:0008038	neuron recognition	25	35	1.03e-03
GO:BP	GO:0060562	epithelial tube morphogenesis	127	261	1.04e-03
GO:BP	GO:0071407	cellular response to organic cyclic compound	176	379	1.08e-03
GO:BP	GO:1990138	neuron projection extension	72	134	1.10e-03
GO:BP	GO:0070169	positive regulation of biomineral tissue development	26	37	1.11e-03
GO:BP	GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	126	259	1.12e-03
GO:BP	GO:0048663	neuron fate commitment	20	26	1.15e-03
GO:BP	GO:0060485	mesenchyme development	120	245	1.16e-03
GO:BP	GO:0045778	positive regulation of ossification	27	39	1.18e-03
GO:BP	GO:0034220	monoatomic ion transmembrane transport	260	587	1.18e-03
GO:BP	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	50	86	1.18e-03
GO:BP	GO:0043062	extracellular structure organization	111	224	1.19e-03
GO:BP	GO:0045229	external encapsulating structure organization	111	224	1.19e-03
GO:BP	GO:0022029	telencephalon cell migration	28	41	1.22e-03
GO:BP	GO:0051247	positive regulation of protein metabolic process	388	911	1.22e-03
GO:BP	GO:0007612	learning	61	110	1.23e-03
GO:BP	GO:0021885	forebrain cell migration	29	43	1.26e-03
GO:BP	GO:0048660	regulation of smooth muscle cell proliferation	55	97	1.27e-03
GO:BP	GO:1903522	regulation of blood circulation	98	194	1.27e-03
GO:BP	GO:0045666	positive regulation of neuron differentiation	36	57	1.29e-03
GO:BP	GO:0044319	wound healing, spreading of cells	21	28	1.32e-03
GO:BP	GO:0090505	epiboly involved in wound healing	21	28	1.32e-03
GO:BP	GO:0014070	response to organic cyclic compound	267	606	1.40e-03
GO:BP	GO:0043269	regulation of monoatomic ion transport	135	282	1.49e-03
GO:BP	GO:0060996	dendritic spine development	45	76	1.49e-03
GO:BP	GO:0001823	mesonephros development	44	74	1.57e-03
GO:BP	GO:0001508	action potential	57	102	1.58e-03
GO:BP	GO:0045995	regulation of embryonic development	43	72	1.63e-03
GO:BP	GO:0001657	ureteric bud development	43	72	1.63e-03
GO:BP	GO:0030501	positive regulation of bone mineralization	23	32	1.67e-03
GO:BP	GO:0072073	kidney epithelium development	61	111	1.67e-03
GO:BP	GO:0048593	camera-type eye morphogenesis	50	87	1.67e-03
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	511	1231	1.67e-03
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	209	463	1.67e-03
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	209	463	1.67e-03
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	512	1234	1.72e-03
GO:BP	GO:0030879	mammary gland development	55	98	1.76e-03
GO:BP	GO:0010717	regulation of epithelial to mesenchymal transition	49	85	1.76e-03
GO:BP	GO:0021795	cerebral cortex cell migration	24	34	1.81e-03
GO:BP	GO:0031345	negative regulation of cell projection organization	76	145	1.84e-03
GO:BP	GO:0086003	cardiac muscle cell contraction	39	64	1.87e-03
GO:BP	GO:0045216	cell-cell junction organization	79	152	1.92e-03
GO:BP	GO:0033002	muscle cell proliferation	79	152	1.92e-03
GO:BP	GO:0010463	mesenchymal cell proliferation	25	36	1.92e-03
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	104	210	1.94e-03
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	104	210	1.94e-03
GO:BP	GO:0040008	regulation of growth	208	462	2.02e-03
GO:BP	GO:0070371	ERK1 and ERK2 cascade	97	194	2.12e-03
GO:BP	GO:0010718	positive regulation of epithelial to mesenchymal transition	31	48	2.21e-03
GO:BP	GO:0051254	positive regulation of RNA metabolic process	557	1354	2.22e-03
GO:BP	GO:0009892	negative regulation of metabolic process	841	2100	2.23e-03
GO:BP	GO:0072164	mesonephric tubule development	43	73	2.39e-03
GO:BP	GO:0048706	embryonic skeletal system development	43	73	2.39e-03
GO:BP	GO:0072163	mesonephric epithelium development	43	73	2.39e-03
GO:BP	GO:0009611	response to wounding	175	382	2.44e-03
GO:BP	GO:0060419	heart growth	42	71	2.51e-03
GO:BP	GO:0043542	endothelial cell migration	88	174	2.64e-03
GO:BP	GO:0035270	endocrine system development	48	84	2.68e-03
GO:BP	GO:0030001	metal ion transport	232	524	2.76e-03
GO:BP	GO:0031214	biomineral tissue development	58	106	2.76e-03
GO:BP	GO:0032970	regulation of actin filament-based process	141	300	2.76e-03
GO:BP	GO:0150115	cell-substrate junction organization	53	95	2.76e-03
GO:BP	GO:0048675	axon extension	53	95	2.76e-03
GO:BP	GO:0090504	epiboly	21	29	2.77e-03
GO:BP	GO:0003231	cardiac ventricle development	62	115	2.81e-03
GO:BP	GO:0003170	heart valve development	39	65	2.83e-03
GO:BP	GO:0060571	morphogenesis of an epithelial fold	13	15	2.91e-03
GO:BP	GO:0045598	regulation of fat cell differentiation	52	93	2.92e-03
GO:BP	GO:0008284	positive regulation of cell population proliferation	264	605	3.00e-03
GO:BP	GO:0007517	muscle organ development	127	267	3.09e-03
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	741	1841	3.11e-03
GO:BP	GO:0055006	cardiac cell development	45	78	3.12e-03
GO:BP	GO:0044093	positive regulation of molecular function	334	783	3.20e-03
GO:BP	GO:0033993	response to lipid	251	573	3.25e-03
GO:BP	GO:0051179	localization	1448	3731	3.27e-03
GO:BP	GO:0018210	peptidyl-threonine modification	44	76	3.28e-03
GO:BP	GO:0051057	positive regulation of small GTPase mediated signal transduction	34	55	3.34e-03
GO:BP	GO:0002573	myeloid leukocyte differentiation	78	152	3.34e-03
GO:BP	GO:0003179	heart valve morphogenesis	34	55	3.34e-03
GO:BP	GO:0048585	negative regulation of response to stimulus	493	1193	3.36e-03
GO:BP	GO:1905207	regulation of cardiocyte differentiation	17	22	3.42e-03
GO:BP	GO:0042471	ear morphogenesis	43	74	3.43e-03
GO:BP	GO:1902105	regulation of leukocyte differentiation	96	194	3.44e-03
GO:BP	GO:0098660	inorganic ion transmembrane transport	230	521	3.45e-03
GO:BP	GO:0006812	monoatomic cation transport	267	614	3.47e-03
GO:BP	GO:0050680	negative regulation of epithelial cell proliferation	54	98	3.48e-03
GO:BP	GO:1990090	cellular response to nerve growth factor stimulus	27	41	3.56e-03
GO:BP	GO:0055013	cardiac muscle cell development	42	72	3.56e-03
GO:BP	GO:1990089	response to nerve growth factor	27	41	3.56e-03
GO:BP	GO:0010812	negative regulation of cell-substrate adhesion	27	41	3.56e-03
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	721	1791	3.65e-03
GO:BP	GO:0031324	negative regulation of cellular metabolic process	775	1934	3.77e-03
GO:BP	GO:0032409	regulation of transporter activity	76	148	3.81e-03
GO:BP	GO:0022407	regulation of cell-cell adhesion	131	278	3.83e-03
GO:BP	GO:0003015	heart process	100	204	3.83e-03
GO:BP	GO:0046328	regulation of JNK cascade	57	105	3.83e-03
GO:BP	GO:0001704	formation of primary germ layer	52	94	3.93e-03
GO:BP	GO:0003272	endocardial cushion formation	18	24	3.95e-03
GO:BP	GO:0007160	cell-matrix adhesion	85	169	3.95e-03
GO:BP	GO:0051246	regulation of protein metabolic process	646	1595	3.95e-03
GO:BP	GO:0009891	positive regulation of biosynthetic process	745	1856	4.05e-03
GO:BP	GO:0034764	positive regulation of transmembrane transport	68	130	4.06e-03
GO:BP	GO:0035115	embryonic forelimb morphogenesis	14	17	4.09e-03
GO:BP	GO:0048659	smooth muscle cell proliferation	55	101	4.39e-03
GO:BP	GO:1901700	response to oxygen-containing compound	453	1093	4.47e-03
GO:BP	GO:0030177	positive regulation of Wnt signaling pathway	59	110	4.47e-03
GO:BP	GO:0010092	specification of animal organ identity	19	26	4.47e-03
GO:BP	GO:0051962	positive regulation of nervous system development	103	212	4.57e-03
GO:BP	GO:0097435	supramolecular fiber organization	273	633	5.34e-03
GO:BP	GO:0060323	head morphogenesis	21	30	5.36e-03
GO:BP	GO:0048546	digestive tract morphogenesis	21	30	5.36e-03
GO:BP	GO:0150146	cell junction disassembly	15	19	5.39e-03
GO:BP	GO:0003156	regulation of animal organ formation	15	19	5.39e-03
GO:BP	GO:0035137	hindlimb morphogenesis	15	19	5.39e-03
GO:BP	GO:0035136	forelimb morphogenesis	15	19	5.39e-03
GO:BP	GO:0042327	positive regulation of phosphorylation	186	415	5.43e-03
GO:BP	GO:0016331	morphogenesis of embryonic epithelium	64	122	5.45e-03
GO:BP	GO:2000630	positive regulation of miRNA metabolic process	31	50	5.59e-03
GO:BP	GO:0098655	monoatomic cation transmembrane transport	218	495	5.59e-03
GO:BP	GO:0018107	peptidyl-threonine phosphorylation	40	69	5.73e-03
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	46	82	5.73e-03
GO:BP	GO:0003197	endocardial cushion development	29	46	5.84e-03
GO:BP	GO:1902895	positive regulation of miRNA transcription	28	44	5.93e-03
GO:BP	GO:0019827	stem cell population maintenance	73	143	5.95e-03
GO:BP	GO:0010596	negative regulation of endothelial cell migration	25	38	5.95e-03
GO:BP	GO:0048013	ephrin receptor signaling pathway	25	38	5.95e-03
GO:BP	GO:0007632	visual behavior	26	40	5.95e-03
GO:BP	GO:0003151	outflow tract morphogenesis	39	67	5.95e-03
GO:BP	GO:0031290	retinal ganglion cell axon guidance	12	14	5.95e-03
GO:BP	GO:2000725	regulation of cardiac muscle cell differentiation	12	14	5.95e-03
GO:BP	GO:0010634	positive regulation of epithelial cell migration	66	127	6.02e-03
GO:BP	GO:0030856	regulation of epithelial cell differentiation	54	100	6.25e-03
GO:BP	GO:0030282	bone mineralization	44	78	6.42e-03
GO:BP	GO:0014912	negative regulation of smooth muscle cell migration	16	21	6.43e-03
GO:BP	GO:0007492	endoderm development	37	63	6.61e-03
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	132	284	6.86e-03
GO:BP	GO:0010586	miRNA metabolic process	48	87	6.89e-03
GO:BP	GO:0110020	regulation of actomyosin structure organization	48	87	6.89e-03
GO:BP	GO:0022898	regulation of transmembrane transporter activity	71	139	6.89e-03
GO:BP	GO:0018193	peptidyl-amino acid modification	241	555	7.16e-03
GO:BP	GO:0060840	artery development	47	85	7.38e-03
GO:BP	GO:0061337	cardiac conduction	47	85	7.38e-03
GO:BP	GO:0031128	developmental induction	17	23	7.40e-03
GO:BP	GO:0098662	inorganic cation transmembrane transport	211	480	7.52e-03
GO:BP	GO:1901342	regulation of vasculature development	96	198	7.53e-03
GO:BP	GO:0008016	regulation of heart contraction	82	165	7.56e-03
GO:BP	GO:0030099	myeloid cell differentiation	135	292	7.61e-03
GO:BP	GO:2000628	regulation of miRNA metabolic process	41	72	7.62e-03
GO:BP	GO:0048863	stem cell differentiation	93	191	7.66e-03
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	777	1951	7.69e-03
GO:BP	GO:0050769	positive regulation of neurogenesis	90	184	7.80e-03
GO:BP	GO:1905208	negative regulation of cardiocyte differentiation	10	11	7.80e-03
GO:BP	GO:0038180	nerve growth factor signaling pathway	10	11	7.80e-03
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	103	215	7.92e-03
GO:BP	GO:0046777	protein autophosphorylation	72	142	7.98e-03
GO:BP	GO:1903689	regulation of wound healing, spreading of epidermal cells	8	8	7.98e-03
GO:BP	GO:0060993	kidney morphogenesis	39	68	8.53e-03
GO:BP	GO:0060047	heart contraction	94	194	8.66e-03
GO:BP	GO:0018105	peptidyl-serine phosphorylation	80	161	8.69e-03
GO:BP	GO:0001952	regulation of cell-matrix adhesion	49	90	8.69e-03
GO:BP	GO:0010464	regulation of mesenchymal cell proliferation	19	27	8.72e-03
GO:BP	GO:0060325	face morphogenesis	19	27	8.72e-03
GO:BP	GO:0060998	regulation of dendritic spine development	30	49	8.73e-03
GO:BP	GO:0042063	gliogenesis	114	242	8.74e-03
GO:BP	GO:0030278	regulation of ossification	44	79	8.76e-03
GO:BP	GO:0007010	cytoskeleton organization	470	1146	8.83e-03
GO:BP	GO:0001570	vasculogenesis	38	66	8.90e-03
GO:BP	GO:0051017	actin filament bundle assembly	67	131	9.03e-03
GO:BP	GO:0043087	regulation of GTPase activity	82	166	9.17e-03
GO:BP	GO:0007044	cell-substrate junction assembly	48	88	9.17e-03
GO:BP	GO:0048565	digestive tract development	48	88	9.17e-03
GO:BP	GO:0098727	maintenance of cell number	73	145	9.21e-03
GO:BP	GO:0051174	regulation of phosphorus metabolic process	338	805	9.24e-03
GO:BP	GO:0060038	cardiac muscle cell proliferation	27	43	9.39e-03
GO:BP	GO:0006915	apoptotic process	558	1377	9.44e-03
GO:BP	GO:0010171	body morphogenesis	26	41	9.55e-03
GO:BP	GO:0021536	diencephalon development	25	39	9.68e-03
GO:BP	GO:0048511	rhythmic process	105	221	9.69e-03
GO:BP	GO:0008542	visual learning	23	35	9.69e-03
GO:BP	GO:0010594	regulation of endothelial cell migration	69	136	9.76e-03
GO:BP	GO:0010811	positive regulation of cell-substrate adhesion	51	95	9.95e-03
GO:BP	GO:0051234	establishment of localization	1257	3240	1.01e-02
GO:BP	GO:0008219	cell death	575	1423	1.03e-02
GO:BP	GO:0042472	inner ear morphogenesis	35	60	1.03e-02
GO:BP	GO:1902893	regulation of miRNA transcription	35	60	1.03e-02
GO:BP	GO:0071559	response to transforming growth factor beta	104	219	1.03e-02
GO:BP	GO:0060349	bone morphogenesis	41	73	1.04e-02
GO:BP	GO:0070374	positive regulation of ERK1 and ERK2 cascade	58	111	1.04e-02
GO:BP	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	68	134	1.04e-02
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	91	188	1.04e-02
GO:BP	GO:0019220	regulation of phosphate metabolic process	337	804	1.05e-02
GO:BP	GO:0021987	cerebral cortex development	50	93	1.05e-02
GO:BP	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	88	181	1.06e-02
GO:BP	GO:0051147	regulation of muscle cell differentiation	61	118	1.07e-02
GO:BP	GO:0007186	G protein-coupled receptor signaling pathway	172	386	1.10e-02
GO:BP	GO:0001934	positive regulation of protein phosphorylation	176	396	1.10e-02
GO:BP	GO:0061572	actin filament bundle organization	67	132	1.12e-02
GO:BP	GO:0043368	positive T cell selection	15	20	1.18e-02
GO:BP	GO:1903131	mononuclear cell differentiation	128	278	1.18e-02
GO:BP	GO:0022030	telencephalon glial cell migration	15	20	1.18e-02
GO:BP	GO:0099560	synaptic membrane adhesion	15	20	1.18e-02
GO:BP	GO:0021801	cerebral cortex radial glia-guided migration	15	20	1.18e-02
GO:BP	GO:0086065	cell communication involved in cardiac conduction	32	54	1.18e-02
GO:BP	GO:0042475	odontogenesis of dentin-containing tooth	32	54	1.18e-02
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	121	261	1.18e-02
GO:BP	GO:0007398	ectoderm development	11	13	1.19e-02
GO:BP	GO:0031032	actomyosin structure organization	89	184	1.19e-02
GO:BP	GO:0006814	sodium ion transport	69	137	1.20e-02
GO:BP	GO:0002040	sprouting angiogenesis	52	98	1.20e-02
GO:BP	GO:0001837	epithelial to mesenchymal transition	69	137	1.20e-02
GO:BP	GO:0007015	actin filament organization	160	357	1.20e-02
GO:BP	GO:0045669	positive regulation of osteoblast differentiation	31	52	1.22e-02
GO:BP	GO:0003012	muscle system process	147	325	1.22e-02
GO:BP	GO:0048878	chemical homeostasis	284	670	1.23e-02
GO:BP	GO:0061035	regulation of cartilage development	30	50	1.28e-02
GO:BP	GO:0051148	negative regulation of muscle cell differentiation	30	50	1.28e-02
GO:BP	GO:0055123	digestive system development	51	96	1.28e-02
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	68	135	1.28e-02
GO:BP	GO:0003018	vascular process in circulatory system	93	194	1.29e-02
GO:BP	GO:0009890	negative regulation of biosynthetic process	654	1635	1.29e-02
GO:BP	GO:0022409	positive regulation of cell-cell adhesion	85	175	1.29e-02
GO:BP	GO:0003148	outflow tract septum morphogenesis	16	22	1.29e-02
GO:BP	GO:0012501	programmed cell death	572	1419	1.30e-02
GO:BP	GO:0048639	positive regulation of developmental growth	61	119	1.34e-02
GO:BP	GO:0032231	regulation of actin filament bundle assembly	46	85	1.35e-02
GO:BP	GO:0086001	cardiac muscle cell action potential	36	63	1.35e-02
GO:BP	GO:0045446	endothelial cell differentiation	46	85	1.35e-02
GO:BP	GO:0021761	limbic system development	46	85	1.35e-02
GO:BP	GO:0097061	dendritic spine organization	36	63	1.35e-02
GO:BP	GO:0035019	somatic stem cell population maintenance	28	46	1.36e-02
GO:BP	GO:0003407	neural retina development	28	46	1.36e-02
GO:BP	GO:0050954	sensory perception of mechanical stimulus	57	110	1.38e-02
GO:BP	GO:0030516	regulation of axon extension	41	74	1.38e-02
GO:BP	GO:0031644	regulation of nervous system process	41	74	1.38e-02
GO:BP	GO:0017145	stem cell division	17	24	1.38e-02
GO:BP	GO:0086002	cardiac muscle cell action potential involved in contraction	27	44	1.40e-02
GO:BP	GO:0061614	miRNA transcription	35	61	1.42e-02
GO:BP	GO:0060491	regulation of cell projection assembly	78	159	1.43e-02
GO:BP	GO:0042391	regulation of membrane potential	129	282	1.44e-02
GO:BP	GO:0007623	circadian rhythm	75	152	1.44e-02
GO:BP	GO:0086009	membrane repolarization	26	42	1.44e-02
GO:BP	GO:0051336	regulation of hydrolase activity	189	431	1.44e-02
GO:BP	GO:0045058	T cell selection	18	26	1.45e-02
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	649	1624	1.45e-02
GO:BP	GO:0060317	cardiac epithelial to mesenchymal transition	19	28	1.51e-02
GO:BP	GO:0120032	regulation of plasma membrane bounded cell projection assembly	77	157	1.53e-02
GO:BP	GO:0001759	organ induction	12	15	1.53e-02
GO:BP	GO:0038179	neurotrophin signaling pathway	23	36	1.53e-02
GO:BP	GO:0043369	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	12	15	1.53e-02
GO:BP	GO:0001937	negative regulation of endothelial cell proliferation	20	30	1.53e-02
GO:BP	GO:0032330	regulation of chondrocyte differentiation	22	34	1.54e-02
GO:BP	GO:0042325	regulation of phosphorylation	288	683	1.55e-02
GO:BP	GO:0010976	positive regulation of neuron projection development	65	129	1.55e-02
GO:BP	GO:0018209	peptidyl-serine modification	82	169	1.57e-02
GO:BP	GO:0046834	lipid phosphorylation	9	10	1.59e-02
GO:BP	GO:0060572	morphogenesis of an epithelial bud	9	10	1.59e-02
GO:BP	GO:0061458	reproductive system development	97	205	1.61e-02
GO:BP	GO:0048754	branching morphogenesis of an epithelial tube	58	113	1.62e-02
GO:BP	GO:0055085	transmembrane transport	380	921	1.64e-02
GO:BP	GO:0061387	regulation of extent of cell growth	47	88	1.64e-02
GO:BP	GO:0010959	regulation of metal ion transport	111	239	1.64e-02
GO:BP	GO:0007254	JNK cascade	64	127	1.67e-02
GO:BP	GO:0044089	positive regulation of cellular component biogenesis	172	390	1.73e-02
GO:BP	GO:0051492	regulation of stress fiber assembly	42	77	1.74e-02
GO:BP	GO:0048332	mesoderm morphogenesis	31	53	1.74e-02
GO:BP	GO:0045639	positive regulation of myeloid cell differentiation	37	66	1.75e-02
GO:BP	GO:0051153	regulation of striated muscle cell differentiation	37	66	1.75e-02
GO:BP	GO:0001558	regulation of cell growth	145	323	1.77e-02
GO:BP	GO:0043067	regulation of programmed cell death	433	1060	1.79e-02
GO:BP	GO:0042060	wound healing	132	291	1.79e-02
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	634	1588	1.79e-02
GO:BP	GO:0010977	negative regulation of neuron projection development	56	109	1.88e-02
GO:BP	GO:0045765	regulation of angiogenesis	92	194	1.92e-02
GO:BP	GO:0051641	cellular localization	1022	2623	1.95e-02
GO:BP	GO:0001932	regulation of protein phosphorylation	271	642	1.96e-02
GO:BP	GO:0003158	endothelium development	52	100	1.96e-02
GO:BP	GO:0043149	stress fiber assembly	48	91	2.01e-02
GO:BP	GO:0030038	contractile actin filament bundle assembly	48	91	2.01e-02
GO:BP	GO:0045600	positive regulation of fat cell differentiation	28	47	2.02e-02
GO:BP	GO:0030048	actin filament-based movement	55	107	2.02e-02
GO:BP	GO:0090066	regulation of anatomical structure size	167	379	2.08e-02
GO:BP	GO:0002360	T cell lineage commitment	14	19	2.09e-02
GO:BP	GO:0021772	olfactory bulb development	14	19	2.09e-02
GO:BP	GO:0060997	dendritic spine morphogenesis	27	45	2.09e-02
GO:BP	GO:0060512	prostate gland morphogenesis	14	19	2.09e-02
GO:BP	GO:2000647	negative regulation of stem cell proliferation	14	19	2.09e-02
GO:BP	GO:0048566	embryonic digestive tract development	14	19	2.09e-02
GO:BP	GO:0060740	prostate gland epithelium morphogenesis	14	19	2.09e-02
GO:BP	GO:0106027	neuron projection organization	39	71	2.10e-02
GO:BP	GO:0042981	regulation of apoptotic process	421	1031	2.10e-02
GO:BP	GO:0007162	negative regulation of cell adhesion	88	185	2.11e-02
GO:BP	GO:0048608	reproductive structure development	95	202	2.18e-02
GO:BP	GO:0048844	artery morphogenesis	33	58	2.22e-02
GO:BP	GO:0072028	nephron morphogenesis	33	58	2.22e-02
GO:BP	GO:0016192	vesicle-mediated transport	467	1152	2.22e-02
GO:BP	GO:0007605	sensory perception of sound	50	96	2.24e-02
GO:BP	GO:0061383	trabecula morphogenesis	25	41	2.26e-02
GO:BP	GO:0086011	membrane repolarization during action potential	15	21	2.27e-02
GO:BP	GO:0021983	pituitary gland development	15	21	2.27e-02
GO:BP	GO:0070252	actin-mediated cell contraction	46	87	2.29e-02
GO:BP	GO:0050773	regulation of dendrite development	42	78	2.30e-02
GO:BP	GO:0001763	morphogenesis of a branching structure	71	145	2.31e-02
GO:BP	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	10	12	2.31e-02
GO:BP	GO:0045176	apical protein localization	10	12	2.31e-02
GO:BP	GO:0002088	lens development in camera-type eye	32	56	2.31e-02
GO:BP	GO:0045670	regulation of osteoclast differentiation	24	39	2.31e-02
GO:BP	GO:0032486	Rap protein signal transduction	10	12	2.31e-02
GO:BP	GO:0014009	glial cell proliferation	24	39	2.31e-02
GO:BP	GO:0048708	astrocyte differentiation	32	56	2.31e-02
GO:BP	GO:0001658	branching involved in ureteric bud morphogenesis	24	39	2.31e-02
GO:BP	GO:0051491	positive regulation of filopodium assembly	16	23	2.38e-02
GO:BP	GO:0043537	negative regulation of blood vessel endothelial cell migration	16	23	2.38e-02
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	604	1514	2.42e-02
GO:BP	GO:0051963	regulation of synapse assembly	41	76	2.43e-02
GO:BP	GO:0048640	negative regulation of developmental growth	45	85	2.43e-02
GO:BP	GO:0001775	cell activation	264	627	2.51e-02
GO:BP	GO:0030857	negative regulation of epithelial cell differentiation	20	31	2.53e-02
GO:BP	GO:0099622	cardiac muscle cell membrane repolarization	20	31	2.53e-02
GO:BP	GO:0060563	neuroepithelial cell differentiation	19	29	2.53e-02
GO:BP	GO:0006810	transport	1154	2984	2.53e-02
GO:BP	GO:0051050	positive regulation of transport	242	571	2.57e-02
GO:BP	GO:0061180	mammary gland epithelium development	30	52	2.59e-02
GO:BP	GO:0001708	cell fate specification	30	52	2.59e-02
GO:BP	GO:0045927	positive regulation of growth	87	184	2.67e-02
GO:BP	GO:0007043	cell-cell junction assembly	54	106	2.70e-02
GO:BP	GO:0002011	morphogenesis of an epithelial sheet	29	50	2.74e-02
GO:BP	GO:0042490	mechanoreceptor differentiation	29	50	2.74e-02
GO:BP	GO:0030199	collagen fibril organization	29	50	2.74e-02
GO:BP	GO:0006936	muscle contraction	116	255	2.85e-02
GO:BP	GO:0035249	synaptic transmission, glutamatergic	34	61	2.87e-02
GO:BP	GO:0008306	associative learning	34	61	2.87e-02
GO:BP	GO:0001656	metanephros development	34	61	2.87e-02
GO:BP	GO:0060113	inner ear receptor cell differentiation	28	48	2.90e-02
GO:BP	GO:0071772	response to BMP	59	118	2.94e-02
GO:BP	GO:0071773	cellular response to BMP stimulus	59	118	2.94e-02
GO:BP	GO:0048485	sympathetic nervous system development	11	14	2.94e-02
GO:BP	GO:0010842	retina layer formation	11	14	2.94e-02
GO:BP	GO:0002363	alpha-beta T cell lineage commitment	11	14	2.94e-02
GO:BP	GO:0008347	glial cell migration	27	46	3.05e-02
GO:BP	GO:0072171	mesonephric tubule morphogenesis	27	46	3.05e-02
GO:BP	GO:0035725	sodium ion transmembrane transport	49	95	3.05e-02
GO:BP	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	99	214	3.11e-02
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	55	109	3.16e-02
GO:BP	GO:0098657	import into cell	261	622	3.19e-02
GO:BP	GO:0060324	face development	26	44	3.20e-02
GO:BP	GO:0002042	cell migration involved in sprouting angiogenesis	26	44	3.20e-02
GO:BP	GO:0014033	neural crest cell differentiation	41	77	3.22e-02
GO:BP	GO:0007600	sensory perception	114	251	3.23e-02
GO:BP	GO:0021954	central nervous system neuron development	32	57	3.24e-02
GO:BP	GO:0001954	positive regulation of cell-matrix adhesion	25	42	3.36e-02
GO:BP	GO:0060601	lateral sprouting from an epithelium	8	9	3.36e-02
GO:BP	GO:1901329	regulation of odontoblast differentiation	8	9	3.36e-02
GO:BP	GO:0045986	negative regulation of smooth muscle contraction	8	9	3.36e-02
GO:BP	GO:0008361	regulation of cell size	71	147	3.37e-02
GO:BP	GO:0006935	chemotaxis	111	244	3.39e-02
GO:BP	GO:0007498	mesoderm development	44	84	3.39e-02
GO:BP	GO:0042330	taxis	111	244	3.39e-02
GO:BP	GO:0055008	cardiac muscle tissue morphogenesis	31	55	3.44e-02
GO:BP	GO:0045668	negative regulation of osteoblast differentiation	23	38	3.68e-02
GO:BP	GO:0061001	regulation of dendritic spine morphogenesis	22	36	3.84e-02
GO:BP	GO:0003203	endocardial cushion morphogenesis	22	36	3.84e-02
GO:BP	GO:0048704	embryonic skeletal system morphogenesis	29	51	3.94e-02
GO:BP	GO:0001707	mesoderm formation	29	51	3.94e-02
GO:BP	GO:0051591	response to cAMP	34	62	3.95e-02
GO:BP	GO:0050865	regulation of cell activation	152	347	3.96e-02
GO:BP	GO:0030509	BMP signaling pathway	55	110	3.96e-02
GO:BP	GO:0007159	leukocyte cell-cell adhesion	100	218	3.96e-02
GO:BP	GO:0010629	negative regulation of gene expression	325	790	4.01e-02
GO:BP	GO:0045926	negative regulation of growth	86	184	4.02e-02
GO:BP	GO:0002053	positive regulation of mesenchymal cell proliferation	14	20	4.04e-02
GO:BP	GO:0021516	dorsal spinal cord development	6	6	4.04e-02
GO:BP	GO:0048617	embryonic foregut morphogenesis	6	6	4.04e-02
GO:BP	GO:1901289	succinyl-CoA catabolic process	6	6	4.04e-02
GO:BP	GO:0072178	nephric duct morphogenesis	6	6	4.04e-02
GO:BP	GO:0050861	positive regulation of B cell receptor signaling pathway	6	6	4.04e-02
GO:BP	GO:0021814	cell motility involved in cerebral cortex radial glia guided migration	6	6	4.04e-02
GO:BP	GO:0050982	detection of mechanical stimulus	20	32	4.05e-02
GO:BP	GO:0008154	actin polymerization or depolymerization	71	148	4.05e-02
GO:BP	GO:0032233	positive regulation of actin filament bundle assembly	28	49	4.13e-02
GO:BP	GO:0060914	heart formation	19	30	4.15e-02
GO:BP	GO:0033688	regulation of osteoblast proliferation	15	22	4.16e-02
GO:BP	GO:0048661	positive regulation of smooth muscle cell proliferation	33	60	4.16e-02
GO:BP	GO:0021675	nerve development	33	60	4.16e-02
GO:BP	GO:1902107	positive regulation of leukocyte differentiation	57	115	4.17e-02
GO:BP	GO:1903708	positive regulation of hemopoiesis	57	115	4.17e-02
GO:BP	GO:0072006	nephron development	57	115	4.17e-02
GO:BP	GO:0030510	regulation of BMP signaling pathway	41	78	4.17e-02
GO:BP	GO:0021799	cerebral cortex radially oriented cell migration	17	26	4.18e-02
GO:BP	GO:0071392	cellular response to estradiol stimulus	16	24	4.18e-02
GO:BP	GO:0048048	embryonic eye morphogenesis	16	24	4.18e-02
GO:BP	GO:0003181	atrioventricular valve morphogenesis	17	26	4.18e-02
GO:BP	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	16	24	4.18e-02
GO:BP	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	17	26	4.18e-02
GO:BP	GO:0110110	positive regulation of animal organ morphogenesis	17	26	4.18e-02
GO:BP	GO:0035282	segmentation	37	69	4.18e-02
GO:BP	GO:0033687	osteoblast proliferation	17	26	4.18e-02
GO:BP	GO:0010721	negative regulation of cell development	85	182	4.19e-02
GO:BP	GO:0033135	regulation of peptidyl-serine phosphorylation	44	85	4.30e-02
GO:BP	GO:0050790	regulation of catalytic activity	364	893	4.37e-02
GO:BP	GO:0061333	renal tubule morphogenesis	32	58	4.38e-02
GO:BP	GO:0008543	fibroblast growth factor receptor signaling pathway	32	58	4.38e-02
GO:BP	GO:0071805	potassium ion transmembrane transport	59	120	4.38e-02
GO:BP	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	56	113	4.43e-02
GO:BP	GO:0055001	muscle cell development	77	163	4.43e-02
GO:BP	GO:0060675	ureteric bud morphogenesis	26	45	4.56e-02
GO:BP	GO:0035331	negative regulation of hippo signaling	9	11	4.61e-02
GO:BP	GO:0021895	cerebral cortex neuron differentiation	9	11	4.61e-02
GO:BP	GO:0090263	positive regulation of canonical Wnt signaling pathway	43	83	4.62e-02
GO:BP	GO:0072088	nephron epithelium morphogenesis	31	56	4.67e-02
GO:BP	GO:0003229	ventricular cardiac muscle tissue development	31	56	4.67e-02
GO:BP	GO:0046928	regulation of neurotransmitter secretion	31	56	4.67e-02
GO:BP	GO:0002682	regulation of immune system process	354	868	4.70e-02
GO:BP	GO:0110053	regulation of actin filament organization	97	212	4.70e-02
GO:BP	GO:0061326	renal tubule development	39	74	4.75e-02
GO:BP	GO:0048864	stem cell development	39	74	4.75e-02
GO:BP	GO:0030316	osteoclast differentiation	35	65	4.78e-02
GO:BP	GO:0051496	positive regulation of stress fiber assembly	25	43	4.78e-02
GO:BP	GO:0009880	embryonic pattern specification	25	43	4.78e-02
GO:BP	GO:0050679	positive regulation of epithelial cell proliferation	68	142	4.93e-02
GO:BP	GO:0019722	calcium-mediated signaling	60	123	4.97e-02
GO:BP	GO:0072078	nephron tubule morphogenesis	30	54	4.97e-02

EARnomtable %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in EAR neargenes") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in EAR neargenes
source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:04510	Focal adhesion	97	169	6.03e-06
KEGG	KEGG:04015	Rap1 signaling pathway	90	162	7.47e-05
KEGG	KEGG:04360	Axon guidance	84	155	4.62e-04
KEGG	KEGG:04512	ECM-receptor interaction	42	66	5.12e-04
KEGG	KEGG:04520	Adherens junction	49	83	1.45e-03
KEGG	KEGG:04310	Wnt signaling pathway	71	133	2.44e-03
KEGG	KEGG:04024	cAMP signaling pathway	75	147	6.33e-03
KEGG	KEGG:04010	MAPK signaling pathway	111	231	6.33e-03
KEGG	KEGG:04726	Serotonergic synapse	35	58	6.33e-03
KEGG	KEGG:05200	Pathways in cancer	177	391	6.33e-03
KEGG	KEGG:05222	Small cell lung cancer	46	82	6.46e-03
KEGG	KEGG:04151	PI3K-Akt signaling pathway	118	250	7.19e-03
KEGG	KEGG:04014	Ras signaling pathway	81	164	9.91e-03
KEGG	KEGG:05202	Transcriptional misregulation in cancer	63	122	9.91e-03
KEGG	KEGG:05412	Arrhythmogenic right ventricular cardiomyopathy	38	67	1.24e-02
KEGG	KEGG:04350	TGF-beta signaling pathway	48	90	1.47e-02
KEGG	KEGG:04810	Regulation of actin cytoskeleton	82	169	1.47e-02
KEGG	KEGG:05205	Proteoglycans in cancer	79	162	1.47e-02
KEGG	KEGG:04514	Cell adhesion molecules	38	69	2.10e-02
KEGG	KEGG:04730	Long-term depression	24	39	2.10e-02
KEGG	KEGG:04390	Hippo signaling pathway	64	129	2.22e-02
KEGG	KEGG:04713	Circadian entrainment	37	68	2.80e-02
KEGG	KEGG:04928	Parathyroid hormone synthesis, secretion and action	41	78	3.73e-02
KEGG	KEGG:04068	FoxO signaling pathway	53	106	3.91e-02
KEGG	KEGG:04974	Protein digestion and absorption	31	56	3.97e-02
KEGG	KEGG:04072	Phospholipase D signaling pathway	53	107	4.66e-02

ESR response genes

# ESR_resgenes <- gost(query = ESR_NG_list$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(ESR_resgenes,"data/GO_KEGG_analysis/ESR_resgenes.RDS")

ESRnom <- gostplot(ESR_resgenes, capped = FALSE, interactive = TRUE)
# ESRnom

ESRnomtable <- ESR_resgenes$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

ESRnomtable %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in ESR neargenes" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in ESR neargenes
source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0032501	multicellular organismal process	2719	4504	6.19e-51
GO:BP	GO:0048856	anatomical structure development	2368	3867	1.05e-48
GO:BP	GO:0009653	anatomical structure morphogenesis	1237	1844	1.90e-47
GO:BP	GO:0032502	developmental process	2521	4179	2.35e-45
GO:BP	GO:0007275	multicellular organism development	1971	3170	2.02e-44
GO:BP	GO:0007154	cell communication	2411	3983	2.68e-44
GO:BP	GO:0023052	signaling	2374	3918	7.47e-44
GO:BP	GO:0048731	system development	1713	2719	3.79e-42
GO:BP	GO:0007165	signal transduction	2187	3611	9.13e-39
GO:BP	GO:0030154	cell differentiation	1746	2803	1.06e-38
GO:BP	GO:0048869	cellular developmental process	1746	2804	1.33e-38
GO:BP	GO:0050896	response to stimulus	3104	5379	5.22e-35
GO:BP	GO:0051716	cellular response to stimulus	2717	4640	6.46e-35
GO:BP	GO:0051239	regulation of multicellular organismal process	1237	1924	5.46e-34
GO:BP	GO:0009888	tissue development	904	1348	2.90e-33
GO:BP	GO:0048513	animal organ development	1279	2004	3.55e-33
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	597	837	4.28e-32
GO:BP	GO:0007399	nervous system development	1136	1775	1.60e-29
GO:BP	GO:0007155	cell adhesion	651	941	7.22e-29
GO:BP	GO:0010646	regulation of cell communication	1503	2444	4.76e-28
GO:BP	GO:0007166	cell surface receptor signaling pathway	1142	1801	2.61e-27
GO:BP	GO:0023051	regulation of signaling	1496	2438	3.01e-27
GO:BP	GO:0035295	tube development	553	787	7.25e-27
GO:BP	GO:0072359	circulatory system development	599	864	8.41e-27
GO:BP	GO:0016477	cell migration	686	1011	9.57e-27
GO:BP	GO:0048468	cell development	1184	1886	5.73e-26
GO:BP	GO:0050793	regulation of developmental process	1076	1697	1.61e-25
GO:BP	GO:0048870	cell motility	745	1120	2.94e-25
GO:BP	GO:0035239	tube morphogenesis	458	638	3.31e-25
GO:BP	GO:0022008	neurogenesis	819	1251	9.61e-25
GO:BP	GO:0003008	system process	752	1139	4.38e-24
GO:BP	GO:0048729	tissue morphogenesis	340	453	6.87e-24
GO:BP	GO:0009887	animal organ morphogenesis	475	673	1.46e-23
GO:BP	GO:0051240	positive regulation of multicellular organismal process	692	1040	2.24e-23
GO:BP	GO:0048699	generation of neurons	711	1076	8.28e-23
GO:BP	GO:2000026	regulation of multicellular organismal development	637	951	1.83e-22
GO:BP	GO:0030182	neuron differentiation	671	1014	1.21e-21
GO:BP	GO:0141124	intracellular signaling cassette	842	1314	2.89e-21
GO:BP	GO:0007267	cell-cell signaling	709	1082	2.91e-21
GO:BP	GO:0009966	regulation of signal transduction	1316	2166	6.52e-21
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	493	717	1.33e-20
GO:BP	GO:0051094	positive regulation of developmental process	607	913	3.88e-20
GO:BP	GO:0030334	regulation of cell migration	461	668	1.15e-19
GO:BP	GO:0001944	vasculature development	391	552	1.24e-19
GO:BP	GO:0050789	regulation of biological process	4101	7516	3.07e-19
GO:BP	GO:0040011	locomotion	540	805	5.25e-19
GO:BP	GO:0048583	regulation of response to stimulus	1605	2717	7.46e-19
GO:BP	GO:2000145	regulation of cell motility	477	700	1.07e-18
GO:BP	GO:0001568	blood vessel development	372	525	1.07e-18
GO:BP	GO:0044057	regulation of system process	285	384	1.07e-18
GO:BP	GO:0065007	biological regulation	4205	7734	1.75e-18
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	422	609	1.86e-18
GO:BP	GO:0040012	regulation of locomotion	488	720	1.89e-18
GO:BP	GO:0060429	epithelium development	530	792	2.43e-18
GO:BP	GO:0034330	cell junction organization	383	545	2.60e-18
GO:BP	GO:0098609	cell-cell adhesion	394	564	3.80e-18
GO:BP	GO:0050794	regulation of cellular process	3906	7153	1.53e-17
GO:BP	GO:0048514	blood vessel morphogenesis	323	450	1.64e-17
GO:BP	GO:0030029	actin filament-based process	437	640	2.59e-17
GO:BP	GO:0002009	morphogenesis of an epithelium	272	369	3.69e-17
GO:BP	GO:0000902	cell morphogenesis	478	713	1.18e-16
GO:BP	GO:0009790	embryo development	541	821	1.22e-16
GO:BP	GO:0071495	cellular response to endogenous stimulus	664	1035	1.36e-16
GO:BP	GO:0035556	intracellular signal transduction	1175	1951	1.58e-16
GO:BP	GO:0045595	regulation of cell differentiation	685	1073	1.95e-16
GO:BP	GO:0045597	positive regulation of cell differentiation	405	591	2.08e-16
GO:BP	GO:0032989	cellular anatomical entity morphogenesis	403	588	2.42e-16
GO:BP	GO:0003013	circulatory system process	305	426	2.87e-16
GO:BP	GO:0048518	positive regulation of biological process	2429	4301	3.13e-16
GO:BP	GO:0060485	mesenchyme development	191	245	3.48e-16
GO:BP	GO:0048519	negative regulation of biological process	2146	3764	3.74e-16
GO:BP	GO:0048522	positive regulation of cellular process	2246	3954	3.89e-16
GO:BP	GO:0048598	embryonic morphogenesis	302	422	4.42e-16
GO:BP	GO:0030155	regulation of cell adhesion	354	508	5.26e-16
GO:BP	GO:0048523	negative regulation of cellular process	2030	3550	9.49e-16
GO:BP	GO:0070848	response to growth factor	376	547	1.55e-15
GO:BP	GO:0007507	heart development	347	499	1.86e-15
GO:BP	GO:0051128	regulation of cellular component organization	1120	1862	1.96e-15
GO:BP	GO:0008015	blood circulation	260	357	2.56e-15
GO:BP	GO:0065008	regulation of biological quality	1136	1893	2.94e-15
GO:BP	GO:0009719	response to endogenous stimulus	749	1197	4.69e-15
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	722	1150	6.09e-15
GO:BP	GO:0048666	neuron development	544	838	7.15e-15
GO:BP	GO:0061061	muscle structure development	367	536	9.31e-15
GO:BP	GO:0030030	cell projection organization	739	1182	1.01e-14
GO:BP	GO:0071363	cellular response to growth factor stimulus	362	528	1.09e-14
GO:BP	GO:0031175	neuron projection development	488	743	1.35e-14
GO:BP	GO:0014706	striated muscle tissue development	167	213	1.47e-14
GO:BP	GO:0048762	mesenchymal cell differentiation	158	200	2.74e-14
GO:BP	GO:0048738	cardiac muscle tissue development	158	201	6.30e-14
GO:BP	GO:0030036	actin cytoskeleton organization	382	566	6.89e-14
GO:BP	GO:0042127	regulation of cell population proliferation	676	1077	6.96e-14
GO:BP	GO:0001525	angiogenesis	271	381	7.21e-14
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	338	494	1.76e-13
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	315	456	2.20e-13
GO:BP	GO:0048858	cell projection morphogenesis	340	498	2.30e-13
GO:BP	GO:0008285	negative regulation of cell population proliferation	322	469	3.95e-13
GO:BP	GO:0051241	negative regulation of multicellular organismal process	460	706	7.81e-13
GO:BP	GO:0060562	epithelial tube morphogenesis	194	261	9.34e-13
GO:BP	GO:0010647	positive regulation of cell communication	749	1218	1.35e-12
GO:BP	GO:0023057	negative regulation of signaling	647	1036	1.35e-12
GO:BP	GO:0007423	sensory organ development	271	387	1.52e-12
GO:BP	GO:0023056	positive regulation of signaling	750	1221	1.80e-12
GO:BP	GO:0007010	cytoskeleton organization	708	1146	1.89e-12
GO:BP	GO:0051049	regulation of transport	681	1098	1.98e-12
GO:BP	GO:0008283	cell population proliferation	797	1306	1.99e-12
GO:BP	GO:0010648	negative regulation of cell communication	645	1034	2.00e-12
GO:BP	GO:0048812	neuron projection morphogenesis	325	479	3.29e-12
GO:BP	GO:0003012	muscle system process	232	325	4.33e-12
GO:BP	GO:0060537	muscle tissue development	240	339	6.98e-12
GO:BP	GO:0001667	ameboidal-type cell migration	243	344	7.18e-12
GO:BP	GO:0051093	negative regulation of developmental process	407	622	1.06e-11
GO:BP	GO:0042221	response to chemical	1336	2304	1.47e-11
GO:BP	GO:0006468	protein phosphorylation	598	958	1.59e-11
GO:BP	GO:0034329	cell junction assembly	229	323	1.99e-11
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	296	435	2.60e-11
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	337	505	3.26e-11
GO:BP	GO:0098657	import into cell	405	622	3.52e-11
GO:BP	GO:0007417	central nervous system development	446	694	4.58e-11
GO:BP	GO:0048589	developmental growth	334	501	4.96e-11
GO:BP	GO:0072001	renal system development	179	244	6.49e-11
GO:BP	GO:0010720	positive regulation of cell development	219	309	6.74e-11
GO:BP	GO:0031344	regulation of cell projection organization	342	516	8.22e-11
GO:BP	GO:0048568	embryonic organ development	215	303	8.93e-11
GO:BP	GO:0048585	negative regulation of response to stimulus	725	1193	1.10e-10
GO:BP	GO:1902531	regulation of intracellular signal transduction	777	1289	1.75e-10
GO:BP	GO:0051960	regulation of nervous system development	236	339	1.76e-10
GO:BP	GO:0060322	head development	354	539	1.98e-10
GO:BP	GO:0072073	kidney epithelium development	92	111	2.23e-10
GO:BP	GO:0030001	metal ion transport	345	524	2.32e-10
GO:BP	GO:0009968	negative regulation of signal transduction	600	972	2.48e-10
GO:BP	GO:0009967	positive regulation of signal transduction	667	1093	3.12e-10
GO:BP	GO:0001501	skeletal system development	240	347	3.22e-10
GO:BP	GO:0003007	heart morphogenesis	161	218	3.42e-10
GO:BP	GO:0003206	cardiac chamber morphogenesis	91	110	3.49e-10
GO:BP	GO:0044087	regulation of cellular component biogenesis	478	757	3.61e-10
GO:BP	GO:0045165	cell fate commitment	118	151	4.59e-10
GO:BP	GO:0003205	cardiac chamber development	118	151	4.59e-10
GO:BP	GO:0090596	sensory organ morphogenesis	132	173	5.78e-10
GO:BP	GO:0007420	brain development	328	498	7.15e-10
GO:BP	GO:0001822	kidney development	172	237	7.36e-10
GO:BP	GO:0032879	regulation of localization	855	1439	9.26e-10
GO:BP	GO:0034762	regulation of transmembrane transport	209	298	9.79e-10
GO:BP	GO:0007186	G protein-coupled receptor signaling pathway	261	386	1.63e-09
GO:BP	GO:0001823	mesonephros development	65	74	1.79e-09
GO:BP	GO:0006936	muscle contraction	182	255	1.94e-09
GO:BP	GO:1903522	regulation of blood circulation	144	194	2.29e-09
GO:BP	GO:0003231	cardiac ventricle development	93	115	2.36e-09
GO:BP	GO:0010975	regulation of neuron projection development	242	355	2.45e-09
GO:BP	GO:0045596	negative regulation of cell differentiation	299	452	2.74e-09
GO:BP	GO:0072164	mesonephric tubule development	64	73	2.95e-09
GO:BP	GO:0072163	mesonephric epithelium development	64	73	2.95e-09
GO:BP	GO:0060284	regulation of cell development	367	570	3.33e-09
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	177	248	3.47e-09
GO:BP	GO:0030335	positive regulation of cell migration	265	395	3.86e-09
GO:BP	GO:0016310	phosphorylation	689	1145	4.94e-09
GO:BP	GO:0001657	ureteric bud development	63	72	4.94e-09
GO:BP	GO:0016043	cellular component organization	2629	4802	5.18e-09
GO:BP	GO:0051179	localization	2071	3731	5.58e-09
GO:BP	GO:0030900	forebrain development	191	272	5.75e-09
GO:BP	GO:2000147	positive regulation of cell motility	272	408	5.80e-09
GO:BP	GO:0007264	small GTPase-mediated signal transduction	261	390	7.69e-09
GO:BP	GO:0090257	regulation of muscle system process	132	177	8.05e-09
GO:BP	GO:0045785	positive regulation of cell adhesion	208	301	8.37e-09
GO:BP	GO:0140352	export from cell	379	594	8.42e-09
GO:BP	GO:0060560	developmental growth involved in morphogenesis	140	190	9.34e-09
GO:BP	GO:0003151	outflow tract morphogenesis	59	67	1.06e-08
GO:BP	GO:0060411	cardiac septum morphogenesis	59	67	1.06e-08
GO:BP	GO:0007409	axonogenesis	229	337	1.18e-08
GO:BP	GO:0061448	connective tissue development	149	205	1.27e-08
GO:BP	GO:0043269	regulation of monoatomic ion transport	196	282	1.27e-08
GO:BP	GO:0001837	epithelial to mesenchymal transition	106	137	1.32e-08
GO:BP	GO:0044093	positive regulation of molecular function	485	783	1.39e-08
GO:BP	GO:0060047	heart contraction	142	194	1.46e-08
GO:BP	GO:0051216	cartilage development	111	145	1.55e-08
GO:BP	GO:0040017	positive regulation of locomotion	275	416	1.62e-08
GO:BP	GO:0030855	epithelial cell differentiation	282	428	1.62e-08
GO:BP	GO:0048880	sensory system development	186	266	1.62e-08
GO:BP	GO:0042692	muscle cell differentiation	220	323	1.82e-08
GO:BP	GO:0099177	regulation of trans-synaptic signaling	220	323	1.82e-08
GO:BP	GO:0061564	axon development	249	372	1.82e-08
GO:BP	GO:0001654	eye development	184	263	1.84e-08
GO:BP	GO:0006810	transport	1673	2984	1.89e-08
GO:BP	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	90	113	1.89e-08
GO:BP	GO:0070887	cellular response to chemical stimulus	1015	1751	2.12e-08
GO:BP	GO:0050808	synapse organization	228	337	2.23e-08
GO:BP	GO:0035265	organ growth	99	127	2.28e-08
GO:BP	GO:0099537	trans-synaptic signaling	304	467	2.31e-08
GO:BP	GO:0050804	modulation of chemical synaptic transmission	219	322	2.36e-08
GO:BP	GO:0009792	embryo development ending in birth or egg hatching	335	521	2.49e-08
GO:BP	GO:0009893	positive regulation of metabolic process	1480	2622	2.65e-08
GO:BP	GO:0002062	chondrocyte differentiation	73	88	2.66e-08
GO:BP	GO:0150063	visual system development	184	264	2.85e-08
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	165	233	3.35e-08
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	301	463	3.37e-08
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	301	463	3.37e-08
GO:BP	GO:0010810	regulation of cell-substrate adhesion	121	162	3.39e-08
GO:BP	GO:0003018	vascular process in circulatory system	141	194	3.39e-08
GO:BP	GO:0065009	regulation of molecular function	768	1299	3.42e-08
GO:BP	GO:0048863	stem cell differentiation	139	191	3.84e-08
GO:BP	GO:0003015	heart process	147	204	3.96e-08
GO:BP	GO:0060419	heart growth	61	71	4.05e-08
GO:BP	GO:0198738	cell-cell signaling by wnt	240	359	4.09e-08
GO:BP	GO:1901888	regulation of cell junction assembly	117	156	4.09e-08
GO:BP	GO:0040007	growth	434	697	4.15e-08
GO:BP	GO:0048584	positive regulation of response to stimulus	879	1504	4.15e-08
GO:BP	GO:0050767	regulation of neurogenesis	199	290	4.29e-08
GO:BP	GO:0097485	neuron projection guidance	127	172	4.29e-08
GO:BP	GO:0007411	axon guidance	127	172	4.29e-08
GO:BP	GO:0003279	cardiac septum development	82	102	4.35e-08
GO:BP	GO:0099536	synaptic signaling	312	483	4.35e-08
GO:BP	GO:0090130	tissue migration	173	247	4.71e-08
GO:BP	GO:0043062	extracellular structure organization	159	224	4.73e-08
GO:BP	GO:0045229	external encapsulating structure organization	159	224	4.73e-08
GO:BP	GO:0001775	cell activation	394	627	4.92e-08
GO:BP	GO:0016055	Wnt signaling pathway	239	358	5.11e-08
GO:BP	GO:0010959	regulation of metal ion transport	168	239	5.22e-08
GO:BP	GO:0046903	secretion	391	622	5.28e-08
GO:BP	GO:0007268	chemical synaptic transmission	300	463	5.48e-08
GO:BP	GO:0098916	anterograde trans-synaptic signaling	300	463	5.48e-08
GO:BP	GO:0071310	cellular response to organic substance	765	1297	6.20e-08
GO:BP	GO:0045216	cell-cell junction organization	114	152	6.21e-08
GO:BP	GO:0008284	positive regulation of cell population proliferation	381	605	6.21e-08
GO:BP	GO:0030198	extracellular matrix organization	158	223	6.36e-08
GO:BP	GO:0043009	chordate embryonic development	325	507	6.45e-08
GO:BP	GO:0010243	response to organonitrogen compound	426	685	6.91e-08
GO:BP	GO:0040013	negative regulation of locomotion	170	243	7.05e-08
GO:BP	GO:0090132	epithelium migration	170	243	7.05e-08
GO:BP	GO:0010631	epithelial cell migration	170	243	7.05e-08
GO:BP	GO:0043410	positive regulation of MAPK cascade	197	288	7.18e-08
GO:BP	GO:0031589	cell-substrate adhesion	179	258	7.25e-08
GO:BP	GO:0008016	regulation of heart contraction	122	165	7.25e-08
GO:BP	GO:0006897	endocytosis	316	492	7.78e-08
GO:BP	GO:0072006	nephron development	90	115	8.05e-08
GO:BP	GO:0010033	response to organic substance	1002	1736	8.14e-08
GO:BP	GO:0031401	positive regulation of protein modification process	349	550	8.55e-08
GO:BP	GO:0097435	supramolecular fiber organization	396	633	9.09e-08
GO:BP	GO:0006816	calcium ion transport	181	262	9.74e-08
GO:BP	GO:0051146	striated muscle cell differentiation	164	234	1.07e-07
GO:BP	GO:0006811	monoatomic ion transport	444	719	1.11e-07
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	1364	2415	1.12e-07
GO:BP	GO:0003208	cardiac ventricle morphogenesis	54	62	1.14e-07
GO:BP	GO:0022407	regulation of cell-cell adhesion	190	278	1.48e-07
GO:BP	GO:0016331	morphogenesis of embryonic epithelium	94	122	1.48e-07
GO:BP	GO:0043010	camera-type eye development	161	230	1.68e-07
GO:BP	GO:0050877	nervous system process	376	600	1.71e-07
GO:BP	GO:0051962	positive regulation of nervous system development	150	212	1.77e-07
GO:BP	GO:0051130	positive regulation of cellular component organization	516	850	1.79e-07
GO:BP	GO:0006915	apoptotic process	805	1377	1.93e-07
GO:BP	GO:0060348	bone development	109	146	2.00e-07
GO:BP	GO:0035148	tube formation	95	124	2.01e-07
GO:BP	GO:0010632	regulation of epithelial cell migration	135	188	2.28e-07
GO:BP	GO:0061035	regulation of cartilage development	45	50	2.39e-07
GO:BP	GO:0071417	cellular response to organonitrogen compound	285	442	2.61e-07
GO:BP	GO:0050673	epithelial cell proliferation	202	300	3.06e-07
GO:BP	GO:0032940	secretion by cell	347	551	3.08e-07
GO:BP	GO:0043408	regulation of MAPK cascade	276	427	3.18e-07
GO:BP	GO:1901698	response to nitrogen compound	451	736	3.30e-07
GO:BP	GO:0070588	calcium ion transmembrane transport	148	210	3.30e-07
GO:BP	GO:0051234	establishment of localization	1795	3240	3.40e-07
GO:BP	GO:0008219	cell death	828	1423	3.56e-07
GO:BP	GO:0031399	regulation of protein modification process	548	911	3.60e-07
GO:BP	GO:0034220	monoatomic ion transmembrane transport	367	587	3.67e-07
GO:BP	GO:0033002	muscle cell proliferation	112	152	4.19e-07
GO:BP	GO:0012501	programmed cell death	825	1419	4.62e-07
GO:BP	GO:0023061	signal release	210	315	5.25e-07
GO:BP	GO:1901700	response to oxygen-containing compound	647	1093	5.44e-07
GO:BP	GO:0009605	response to external stimulus	900	1559	5.67e-07
GO:BP	GO:0061138	morphogenesis of a branching epithelium	101	135	5.72e-07
GO:BP	GO:0071773	cellular response to BMP stimulus	90	118	7.05e-07
GO:BP	GO:0071772	response to BMP	90	118	7.05e-07
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	147	210	7.29e-07
GO:BP	GO:0031325	positive regulation of cellular metabolic process	1313	2333	7.32e-07
GO:BP	GO:0001763	morphogenesis of a branching structure	107	145	7.56e-07
GO:BP	GO:0006937	regulation of muscle contraction	95	126	7.75e-07
GO:BP	GO:0098660	inorganic ion transmembrane transport	328	521	7.90e-07
GO:BP	GO:0061326	renal tubule development	61	74	8.38e-07
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	191	284	8.38e-07
GO:BP	GO:0051046	regulation of secretion	256	396	1.02e-06
GO:BP	GO:0072175	epithelial tube formation	89	117	1.03e-06
GO:BP	GO:0055017	cardiac muscle tissue growth	54	64	1.10e-06
GO:BP	GO:0001503	ossification	201	302	1.24e-06
GO:BP	GO:1901342	regulation of vasculature development	139	198	1.29e-06
GO:BP	GO:0045664	regulation of neuron differentiation	97	130	1.33e-06
GO:BP	GO:0010717	regulation of epithelial to mesenchymal transition	68	85	1.35e-06
GO:BP	GO:0007159	leukocyte cell-cell adhesion	151	218	1.36e-06
GO:BP	GO:0007162	negative regulation of cell adhesion	131	185	1.38e-06
GO:BP	GO:0060038	cardiac muscle cell proliferation	39	43	1.41e-06
GO:BP	GO:0030336	negative regulation of cell migration	146	210	1.55e-06
GO:BP	GO:0007610	behavior	269	420	1.57e-06
GO:BP	GO:0048562	embryonic organ morphogenesis	129	182	1.58e-06
GO:BP	GO:0042472	inner ear morphogenesis	51	60	1.58e-06
GO:BP	GO:0009611	response to wounding	247	382	1.68e-06
GO:BP	GO:0035051	cardiocyte differentiation	98	132	1.68e-06
GO:BP	GO:0007369	gastrulation	103	140	1.69e-06
GO:BP	GO:0007389	pattern specification process	191	286	1.78e-06
GO:BP	GO:2000146	negative regulation of cell motility	150	217	1.79e-06
GO:BP	GO:0050769	positive regulation of neurogenesis	130	184	1.86e-06
GO:BP	GO:1901701	cellular response to oxygen-containing compound	480	796	1.86e-06
GO:BP	GO:0055085	transmembrane transport	549	921	1.86e-06
GO:BP	GO:0030048	actin filament-based movement	82	107	1.90e-06
GO:BP	GO:0006935	chemotaxis	166	244	1.95e-06
GO:BP	GO:0042330	taxis	166	244	1.95e-06
GO:BP	GO:0003281	ventricular septum development	57	69	1.95e-06
GO:BP	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	61	75	2.05e-06
GO:BP	GO:0030510	regulation of BMP signaling pathway	63	78	2.05e-06
GO:BP	GO:0045321	leukocyte activation	331	530	2.06e-06
GO:BP	GO:0046777	protein autophosphorylation	104	142	2.07e-06
GO:BP	GO:0043085	positive regulation of catalytic activity	340	546	2.08e-06
GO:BP	GO:0006796	phosphate-containing compound metabolic process	1069	1883	2.08e-06
GO:BP	GO:0003229	ventricular cardiac muscle tissue development	48	56	2.17e-06
GO:BP	GO:0007015	actin filament organization	232	357	2.19e-06
GO:BP	GO:0044089	positive regulation of cellular component biogenesis	251	390	2.24e-06
GO:BP	GO:0006812	monoatomic cation transport	378	614	2.31e-06
GO:BP	GO:2000027	regulation of animal organ morphogenesis	50	59	2.45e-06
GO:BP	GO:0150115	cell-substrate junction organization	74	95	2.46e-06
GO:BP	GO:0051174	regulation of phosphorus metabolic process	484	805	2.62e-06
GO:BP	GO:0042327	positive regulation of phosphorylation	265	415	2.69e-06
GO:BP	GO:0098662	inorganic cation transmembrane transport	302	480	2.78e-06
GO:BP	GO:0007517	muscle organ development	179	267	2.87e-06
GO:BP	GO:0048839	inner ear development	98	133	2.92e-06
GO:BP	GO:0060993	kidney morphogenesis	56	68	2.99e-06
GO:BP	GO:0048645	animal organ formation	45	52	2.99e-06
GO:BP	GO:0051247	positive regulation of protein metabolic process	542	911	3.04e-06
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	145	210	3.05e-06
GO:BP	GO:0019220	regulation of phosphate metabolic process	483	804	3.05e-06
GO:BP	GO:0014033	neural crest cell differentiation	62	77	3.06e-06
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	433	714	3.17e-06
GO:BP	GO:0051050	positive regulation of transport	353	571	3.29e-06
GO:BP	GO:0043583	ear development	109	151	3.37e-06
GO:BP	GO:0055008	cardiac muscle tissue morphogenesis	47	55	3.45e-06
GO:BP	GO:0098655	monoatomic cation transmembrane transport	310	495	3.46e-06
GO:BP	GO:0006793	phosphorus metabolic process	1078	1904	3.53e-06
GO:BP	GO:0001704	formation of primary germ layer	73	94	3.59e-06
GO:BP	GO:0042592	homeostatic process	665	1137	3.62e-06
GO:BP	GO:0030111	regulation of Wnt signaling pathway	175	261	3.77e-06
GO:BP	GO:0072028	nephron morphogenesis	49	58	3.81e-06
GO:BP	GO:0061333	renal tubule morphogenesis	49	58	3.81e-06
GO:BP	GO:0048844	artery morphogenesis	49	58	3.81e-06
GO:BP	GO:0045765	regulation of angiogenesis	135	194	3.94e-06
GO:BP	GO:0007044	cell-substrate junction assembly	69	88	3.99e-06
GO:BP	GO:0051924	regulation of calcium ion transport	110	153	4.04e-06
GO:BP	GO:0060415	muscle tissue morphogenesis	51	61	4.12e-06
GO:BP	GO:0061337	cardiac conduction	67	85	4.17e-06
GO:BP	GO:0048644	muscle organ morphogenesis	53	64	4.37e-06
GO:BP	GO:0072080	nephron tubule development	57	70	4.61e-06
GO:BP	GO:0042391	regulation of membrane potential	187	282	4.61e-06
GO:BP	GO:0030509	BMP signaling pathway	83	110	4.62e-06
GO:BP	GO:0071840	cellular component organization or biogenesis	2690	4988	5.01e-06
GO:BP	GO:0022612	gland morphogenesis	72	93	5.24e-06
GO:BP	GO:1901699	cellular response to nitrogen compound	300	479	5.24e-06
GO:BP	GO:0042060	wound healing	192	291	5.39e-06
GO:BP	GO:0048167	regulation of synaptic plasticity	101	139	5.46e-06
GO:BP	GO:0001952	regulation of cell-matrix adhesion	70	90	5.56e-06
GO:BP	GO:0000165	MAPK cascade	314	504	5.56e-06
GO:BP	GO:0022409	positive regulation of cell-cell adhesion	123	175	5.72e-06
GO:BP	GO:0070252	actin-mediated cell contraction	68	87	5.90e-06
GO:BP	GO:0060070	canonical Wnt signaling pathway	163	242	6.11e-06
GO:BP	GO:0072009	nephron epithelium development	66	84	6.22e-06
GO:BP	GO:0014070	response to organic cyclic compound	371	606	6.31e-06
GO:BP	GO:0060412	ventricular septum morphogenesis	36	40	6.35e-06
GO:BP	GO:0060421	positive regulation of heart growth	27	28	6.52e-06
GO:BP	GO:0001932	regulation of protein phosphorylation	391	642	6.52e-06
GO:BP	GO:0009987	cellular process	5561	10686	6.84e-06
GO:BP	GO:0021915	neural tube development	97	133	6.88e-06
GO:BP	GO:0090288	negative regulation of cellular response to growth factor stimulus	60	75	6.88e-06
GO:BP	GO:0006941	striated muscle contraction	105	146	7.11e-06
GO:BP	GO:0001838	embryonic epithelial tube formation	80	106	7.20e-06
GO:BP	GO:0031214	biomineral tissue development	80	106	7.20e-06
GO:BP	GO:0018212	peptidyl-tyrosine modification	116	164	7.20e-06
GO:BP	GO:0051336	regulation of hydrolase activity	272	431	7.29e-06
GO:BP	GO:0001934	positive regulation of protein phosphorylation	252	396	7.41e-06
GO:BP	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	67	86	8.72e-06
GO:BP	GO:0050803	regulation of synapse structure or activity	123	176	9.02e-06
GO:BP	GO:0072088	nephron epithelium morphogenesis	47	56	9.52e-06
GO:BP	GO:0060048	cardiac muscle contraction	86	116	9.88e-06
GO:BP	GO:0050807	regulation of synapse organization	121	173	1.04e-05
GO:BP	GO:0002521	leukocyte differentiation	237	371	1.07e-05
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	130	188	1.07e-05
GO:BP	GO:0032970	regulation of actin filament-based process	196	300	1.09e-05
GO:BP	GO:1903530	regulation of secretion by cell	234	366	1.14e-05
GO:BP	GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	172	259	1.15e-05
GO:BP	GO:0009628	response to abiotic stimulus	483	811	1.16e-05
GO:BP	GO:0035108	limb morphogenesis	82	110	1.22e-05
GO:BP	GO:0035107	appendage morphogenesis	82	110	1.22e-05
GO:BP	GO:0060420	regulation of heart growth	42	49	1.23e-05
GO:BP	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	108	152	1.24e-05
GO:BP	GO:0060045	positive regulation of cardiac muscle cell proliferation	22	22	1.24e-05
GO:BP	GO:0003148	outflow tract septum morphogenesis	22	22	1.24e-05
GO:BP	GO:0009612	response to mechanical stimulus	108	152	1.24e-05
GO:BP	GO:0060840	artery development	66	85	1.28e-05
GO:BP	GO:0042325	regulation of phosphorylation	412	683	1.28e-05
GO:BP	GO:0018108	peptidyl-tyrosine phosphorylation	114	162	1.32e-05
GO:BP	GO:0060043	regulation of cardiac muscle cell proliferation	29	31	1.32e-05
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	64	82	1.35e-05
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	1222	2186	1.35e-05
GO:BP	GO:1903037	regulation of leukocyte cell-cell adhesion	135	197	1.39e-05
GO:BP	GO:0003179	heart valve morphogenesis	46	55	1.49e-05
GO:BP	GO:0060395	SMAD protein signal transduction	60	76	1.50e-05
GO:BP	GO:0098771	inorganic ion homeostasis	223	348	1.58e-05
GO:BP	GO:0007160	cell-matrix adhesion	118	169	1.58e-05
GO:BP	GO:0048588	developmental cell growth	124	179	1.61e-05
GO:BP	GO:0055074	calcium ion homeostasis	146	216	1.71e-05
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	81	109	1.72e-05
GO:BP	GO:0007498	mesoderm development	65	84	1.90e-05
GO:BP	GO:0032409	regulation of transporter activity	105	148	1.92e-05
GO:BP	GO:0097553	calcium ion transmembrane import into cytosol	89	122	1.92e-05
GO:BP	GO:0050806	positive regulation of synaptic transmission	79	106	1.92e-05
GO:BP	GO:0110110	positive regulation of animal organ morphogenesis	25	26	2.07e-05
GO:BP	GO:0043270	positive regulation of monoatomic ion transport	92	127	2.10e-05
GO:BP	GO:0032330	regulation of chondrocyte differentiation	31	34	2.12e-05
GO:BP	GO:0003161	cardiac conduction system development	31	34	2.12e-05
GO:BP	GO:0050678	regulation of epithelial cell proliferation	165	249	2.25e-05
GO:BP	GO:0090066	regulation of anatomical structure size	240	379	2.29e-05
GO:BP	GO:1905314	semi-lunar valve development	36	41	2.29e-05
GO:BP	GO:0035924	cellular response to vascular endothelial growth factor stimulus	45	54	2.33e-05
GO:BP	GO:0072078	nephron tubule morphogenesis	45	54	2.33e-05
GO:BP	GO:0014910	regulation of smooth muscle cell migration	45	54	2.33e-05
GO:BP	GO:0010817	regulation of hormone levels	205	318	2.33e-05
GO:BP	GO:0048660	regulation of smooth muscle cell proliferation	73	97	2.61e-05
GO:BP	GO:0048732	gland development	199	308	2.64e-05
GO:BP	GO:0006874	intracellular calcium ion homeostasis	137	202	2.70e-05
GO:BP	GO:0046879	hormone secretion	137	202	2.70e-05
GO:BP	GO:0048771	tissue remodeling	83	113	2.73e-05
GO:BP	GO:0048754	branching morphogenesis of an epithelial tube	83	113	2.73e-05
GO:BP	GO:0055010	ventricular cardiac muscle tissue morphogenesis	38	44	2.74e-05
GO:BP	GO:0022898	regulation of transmembrane transporter activity	99	139	2.85e-05
GO:BP	GO:0031346	positive regulation of cell projection organization	186	286	3.07e-05
GO:BP	GO:0048041	focal adhesion assembly	60	77	3.18e-05
GO:BP	GO:0050865	regulation of cell activation	221	347	3.25e-05
GO:BP	GO:0099003	vesicle-mediated transport in synapse	117	169	3.29e-05
GO:BP	GO:0001649	osteoblast differentiation	120	174	3.29e-05
GO:BP	GO:0015833	peptide transport	123	179	3.29e-05
GO:BP	GO:0031644	regulation of nervous system process	58	74	3.33e-05
GO:BP	GO:0048864	stem cell development	58	74	3.33e-05
GO:BP	GO:0042471	ear morphogenesis	58	74	3.33e-05
GO:BP	GO:0046649	lymphocyte activation	276	444	3.36e-05
GO:BP	GO:0048592	eye morphogenesis	79	107	3.41e-05
GO:BP	GO:0055023	positive regulation of cardiac muscle tissue growth	24	25	3.65e-05
GO:BP	GO:0003170	heart valve development	52	65	3.77e-05
GO:BP	GO:0043087	regulation of GTPase activity	115	166	3.77e-05
GO:BP	GO:0035296	regulation of tube diameter	75	101	4.29e-05
GO:BP	GO:0007163	establishment or maintenance of cell polarity	125	183	4.29e-05
GO:BP	GO:0035150	regulation of tube size	75	101	4.29e-05
GO:BP	GO:0097746	blood vessel diameter maintenance	75	101	4.29e-05
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	96	135	4.45e-05
GO:BP	GO:0006813	potassium ion transport	96	135	4.45e-05
GO:BP	GO:0003002	regionalization	169	258	4.65e-05
GO:BP	GO:0010634	positive regulation of epithelial cell migration	91	127	4.83e-05
GO:BP	GO:0050878	regulation of body fluid levels	152	229	4.83e-05
GO:BP	GO:0009914	hormone transport	139	207	5.02e-05
GO:BP	GO:0072171	mesonephric tubule morphogenesis	39	46	5.02e-05
GO:BP	GO:0048878	chemical homeostasis	401	670	5.04e-05
GO:BP	GO:0048638	regulation of developmental growth	160	243	5.41e-05
GO:BP	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	143	214	5.43e-05
GO:BP	GO:0071407	cellular response to organic cyclic compound	238	379	5.89e-05
GO:BP	GO:0072091	regulation of stem cell proliferation	49	61	5.89e-05
GO:BP	GO:0009891	positive regulation of biosynthetic process	1040	1856	6.19e-05
GO:BP	GO:0030097	hemopoiesis	375	624	6.22e-05
GO:BP	GO:0060078	regulation of postsynaptic membrane potential	60	78	6.44e-05
GO:BP	GO:0031032	actomyosin structure organization	125	184	6.44e-05
GO:BP	GO:0003272	endocardial cushion formation	23	24	6.53e-05
GO:BP	GO:0051345	positive regulation of hydrolase activity	173	266	6.68e-05
GO:BP	GO:0010628	positive regulation of gene expression	442	746	6.76e-05
GO:BP	GO:0048736	appendage development	96	136	7.25e-05
GO:BP	GO:0060173	limb development	96	136	7.25e-05
GO:BP	GO:0014812	muscle cell migration	56	72	7.43e-05
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	1031	1841	7.75e-05
GO:BP	GO:0003184	pulmonary valve morphogenesis	19	19	7.75e-05
GO:BP	GO:0014032	neural crest cell development	54	69	7.88e-05
GO:BP	GO:0006939	smooth muscle contraction	54	69	7.88e-05
GO:BP	GO:0060675	ureteric bud morphogenesis	38	45	8.03e-05
GO:BP	GO:1902107	positive regulation of leukocyte differentiation	83	115	8.09e-05
GO:BP	GO:1903708	positive regulation of hemopoiesis	83	115	8.09e-05
GO:BP	GO:0042110	T cell activation	195	305	8.59e-05
GO:BP	GO:0010718	positive regulation of epithelial to mesenchymal transition	40	48	8.60e-05
GO:BP	GO:0021953	central nervous system neuron differentiation	73	99	8.60e-05
GO:BP	GO:0071805	potassium ion transmembrane transport	86	120	8.61e-05
GO:BP	GO:0055001	muscle cell development	112	163	8.88e-05
GO:BP	GO:0001707	mesoderm formation	42	51	8.89e-05
GO:BP	GO:0014909	smooth muscle cell migration	48	60	8.89e-05
GO:BP	GO:0072132	mesenchyme morphogenesis	42	51	8.89e-05
GO:BP	GO:0045666	positive regulation of neuron differentiation	46	57	9.01e-05
GO:BP	GO:0043067	regulation of programmed cell death	612	1060	9.15e-05
GO:BP	GO:0070372	regulation of ERK1 and ERK2 cascade	119	175	9.88e-05
GO:BP	GO:0006949	syncytium formation	33	38	1.00e-04
GO:BP	GO:0031345	negative regulation of cell projection organization	101	145	1.01e-04
GO:BP	GO:0050790	regulation of catalytic activity	521	893	1.02e-04
GO:BP	GO:0008544	epidermis development	139	209	1.04e-04
GO:BP	GO:0008150	biological_process	5821	11244	1.13e-04
GO:BP	GO:0061036	positive regulation of cartilage development	22	23	1.15e-04
GO:BP	GO:0002063	chondrocyte development	22	23	1.15e-04
GO:BP	GO:0070371	ERK1 and ERK2 cascade	130	194	1.16e-04
GO:BP	GO:0060541	respiratory system development	111	162	1.17e-04
GO:BP	GO:0048639	positive regulation of developmental growth	85	119	1.18e-04
GO:BP	GO:0045667	regulation of osteoblast differentiation	72	98	1.21e-04
GO:BP	GO:0030010	establishment of cell polarity	88	124	1.24e-04
GO:BP	GO:0055021	regulation of cardiac muscle tissue growth	37	44	1.27e-04
GO:BP	GO:0060976	coronary vasculature development	37	44	1.27e-04
GO:BP	GO:0042981	regulation of apoptotic process	595	1031	1.31e-04
GO:BP	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	94	134	1.31e-04
GO:BP	GO:0046883	regulation of hormone secretion	112	164	1.33e-04
GO:BP	GO:0014855	striated muscle cell proliferation	47	59	1.34e-04
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	135	203	1.39e-04
GO:BP	GO:0048332	mesoderm morphogenesis	43	53	1.39e-04
GO:BP	GO:0051249	regulation of lymphocyte activation	179	279	1.47e-04
GO:BP	GO:0003158	endothelium development	73	100	1.50e-04
GO:BP	GO:0002790	peptide secretion	113	166	1.52e-04
GO:BP	GO:0010594	regulation of endothelial cell migration	95	136	1.54e-04
GO:BP	GO:1903039	positive regulation of leukocyte cell-cell adhesion	101	146	1.57e-04
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	1001	1791	1.61e-04
GO:BP	GO:0003176	aortic valve development	32	37	1.63e-04
GO:BP	GO:0055007	cardiac muscle cell differentiation	76	105	1.63e-04
GO:BP	GO:0050708	regulation of protein secretion	120	178	1.64e-04
GO:BP	GO:0021537	telencephalon development	130	195	1.66e-04
GO:BP	GO:0019722	calcium-mediated signaling	87	123	1.67e-04
GO:BP	GO:0030513	positive regulation of BMP signaling pathway	27	30	1.72e-04
GO:BP	GO:0048705	skeletal system morphogenesis	102	148	1.81e-04
GO:BP	GO:0002694	regulation of leukocyte activation	198	313	1.85e-04
GO:BP	GO:0050770	regulation of axonogenesis	88	125	2.00e-04
GO:BP	GO:0048663	neuron fate commitment	24	26	2.04e-04
GO:BP	GO:0010092	specification of animal organ identity	24	26	2.04e-04
GO:BP	GO:0003177	pulmonary valve development	21	22	2.04e-04
GO:BP	GO:0050870	positive regulation of T cell activation	94	135	2.07e-04
GO:BP	GO:0051893	regulation of focal adhesion assembly	44	55	2.09e-04
GO:BP	GO:0003197	endocardial cushion development	38	46	2.09e-04
GO:BP	GO:0090109	regulation of cell-substrate junction assembly	44	55	2.09e-04
GO:BP	GO:0060390	regulation of SMAD protein signal transduction	40	49	2.13e-04
GO:BP	GO:1902105	regulation of leukocyte differentiation	129	194	2.14e-04
GO:BP	GO:0071692	protein localization to extracellular region	165	256	2.18e-04
GO:BP	GO:2000648	positive regulation of stem cell proliferation	29	33	2.21e-04
GO:BP	GO:0003180	aortic valve morphogenesis	29	33	2.21e-04
GO:BP	GO:0061572	actin filament bundle organization	92	132	2.37e-04
GO:BP	GO:0002573	myeloid leukocyte differentiation	104	152	2.37e-04
GO:BP	GO:0070482	response to oxygen levels	170	265	2.39e-04
GO:BP	GO:0048565	digestive tract development	65	88	2.39e-04
GO:BP	GO:0001935	endothelial cell proliferation	81	114	2.51e-04
GO:BP	GO:0036211	protein modification process	1263	2291	2.54e-04
GO:BP	GO:0048659	smooth muscle cell proliferation	73	101	2.55e-04
GO:BP	GO:0060445	branching involved in salivary gland morphogenesis	17	17	2.58e-04
GO:BP	GO:0061351	neural precursor cell proliferation	84	119	2.60e-04
GO:BP	GO:0140253	cell-cell fusion	31	36	2.61e-04
GO:BP	GO:0038084	vascular endothelial growth factor signaling pathway	31	36	2.61e-04
GO:BP	GO:0000768	syncytium formation by plasma membrane fusion	31	36	2.61e-04
GO:BP	GO:0010463	mesenchymal cell proliferation	31	36	2.61e-04
GO:BP	GO:0045446	endothelial cell differentiation	63	85	2.66e-04
GO:BP	GO:0007492	endoderm development	49	63	2.68e-04
GO:BP	GO:0007043	cell-cell junction assembly	76	106	2.70e-04
GO:BP	GO:1990138	neuron projection extension	93	134	2.72e-04
GO:BP	GO:0150116	regulation of cell-substrate junction organization	47	60	2.85e-04
GO:BP	GO:1902893	regulation of miRNA transcription	47	60	2.85e-04
GO:BP	GO:0002040	sprouting angiogenesis	71	98	2.87e-04
GO:BP	GO:0001658	branching involved in ureteric bud morphogenesis	33	39	2.90e-04
GO:BP	GO:0071774	response to fibroblast growth factor	61	82	2.96e-04
GO:BP	GO:0051283	negative regulation of sequestering of calcium ion	66	90	2.96e-04
GO:BP	GO:0071559	response to transforming growth factor beta	143	219	2.97e-04
GO:BP	GO:1903131	mononuclear cell differentiation	177	278	2.97e-04
GO:BP	GO:0006954	inflammatory response	260	425	3.08e-04
GO:BP	GO:0032835	glomerulus development	43	54	3.11e-04
GO:BP	GO:0086065	cell communication involved in cardiac conduction	43	54	3.11e-04
GO:BP	GO:0051017	actin filament bundle assembly	91	131	3.11e-04
GO:BP	GO:1903169	regulation of calcium ion transmembrane transport	77	108	3.23e-04
GO:BP	GO:0042476	odontogenesis	59	79	3.27e-04
GO:BP	GO:0044344	cellular response to fibroblast growth factor stimulus	59	79	3.27e-04
GO:BP	GO:0048593	camera-type eye morphogenesis	64	87	3.30e-04
GO:BP	GO:0014020	primary neural tube formation	64	87	3.30e-04
GO:BP	GO:0030326	embryonic limb morphogenesis	64	87	3.30e-04
GO:BP	GO:0035113	embryonic appendage morphogenesis	64	87	3.30e-04
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	167	261	3.35e-04
GO:BP	GO:0050863	regulation of T cell activation	134	204	3.45e-04
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	263	431	3.51e-04
GO:BP	GO:0002064	epithelial cell development	101	148	3.51e-04
GO:BP	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	95	138	3.58e-04
GO:BP	GO:0001841	neural tube formation	67	92	3.63e-04
GO:BP	GO:0010721	negative regulation of cell development	121	182	3.74e-04
GO:BP	GO:0060349	bone morphogenesis	55	73	4.03e-04
GO:BP	GO:0051209	release of sequestered calcium ion into cytosol	65	89	4.13e-04
GO:BP	GO:0006942	regulation of striated muscle contraction	60	81	4.16e-04
GO:BP	GO:0045860	positive regulation of protein kinase activity	122	184	4.16e-04
GO:BP	GO:0046622	positive regulation of organ growth	30	35	4.16e-04
GO:BP	GO:0030072	peptide hormone secretion	109	162	4.32e-04
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	140	215	4.32e-04
GO:BP	GO:0045444	fat cell differentiation	119	179	4.33e-04
GO:BP	GO:0098659	inorganic cation import across plasma membrane	53	70	4.40e-04
GO:BP	GO:0016049	cell growth	235	382	4.40e-04
GO:BP	GO:0099565	chemical synaptic transmission, postsynaptic	53	70	4.40e-04
GO:BP	GO:0099587	inorganic ion import across plasma membrane	53	70	4.40e-04
GO:BP	GO:0043616	keratinocyte proliferation	32	38	4.56e-04
GO:BP	GO:0099173	postsynapse organization	100	147	4.61e-04
GO:BP	GO:0050679	positive regulation of epithelial cell proliferation	97	142	4.69e-04
GO:BP	GO:2000463	positive regulation of excitatory postsynaptic potential	25	28	4.70e-04
GO:BP	GO:0098739	import across plasma membrane	85	122	4.70e-04
GO:BP	GO:0030073	insulin secretion	94	137	4.72e-04
GO:BP	GO:0098815	modulation of excitatory postsynaptic potential	34	41	4.78e-04
GO:BP	GO:1905330	regulation of morphogenesis of an epithelium	34	41	4.78e-04
GO:BP	GO:0048010	vascular endothelial growth factor receptor signaling pathway	40	50	4.78e-04
GO:BP	GO:0034332	adherens junction organization	36	44	4.89e-04
GO:BP	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	66	91	5.02e-04
GO:BP	GO:0034767	positive regulation of monoatomic ion transmembrane transport	66	91	5.02e-04
GO:BP	GO:0009306	protein secretion	161	252	5.06e-04
GO:BP	GO:0035592	establishment of protein localization to extracellular region	161	252	5.06e-04
GO:BP	GO:0086003	cardiac muscle cell contraction	49	64	5.24e-04
GO:BP	GO:0016358	dendrite development	121	183	5.26e-04
GO:BP	GO:0030324	lung development	98	144	5.28e-04
GO:BP	GO:0055123	digestive system development	69	96	5.36e-04
GO:BP	GO:0061614	miRNA transcription	47	61	5.69e-04
GO:BP	GO:0042063	gliogenesis	155	242	5.80e-04
GO:BP	GO:0051251	positive regulation of lymphocyte activation	122	185	5.82e-04
GO:BP	GO:0030098	lymphocyte differentiation	159	249	5.83e-04
GO:BP	GO:0042886	amide transport	133	204	6.02e-04
GO:BP	GO:0043069	negative regulation of programmed cell death	378	642	6.10e-04
GO:BP	GO:0016192	vesicle-mediated transport	654	1152	6.14e-04
GO:BP	GO:1904018	positive regulation of vasculature development	81	116	6.18e-04
GO:BP	GO:0007416	synapse assembly	93	136	6.18e-04
GO:BP	GO:0051051	negative regulation of transport	180	286	6.18e-04
GO:BP	GO:0051235	maintenance of location	160	251	6.25e-04
GO:BP	GO:0032526	response to retinoic acid	57	77	6.51e-04
GO:BP	GO:0001666	response to hypoxia	149	232	6.58e-04
GO:BP	GO:0006898	receptor-mediated endocytosis	120	182	6.71e-04
GO:BP	GO:0030323	respiratory tube development	100	148	6.76e-04
GO:BP	GO:0001708	cell fate specification	41	52	6.91e-04
GO:BP	GO:0001570	vasculogenesis	50	66	6.93e-04
GO:BP	GO:0050796	regulation of insulin secretion	79	113	7.12e-04
GO:BP	GO:0050920	regulation of chemotaxis	91	133	7.15e-04
GO:BP	GO:0030100	regulation of endocytosis	128	196	7.32e-04
GO:BP	GO:0071526	semaphorin-plexin signaling pathway	35	43	7.54e-04
GO:BP	GO:0036293	response to decreased oxygen levels	155	243	7.73e-04
GO:BP	GO:0050801	monoatomic ion homeostasis	247	406	7.73e-04
GO:BP	GO:0007215	glutamate receptor signaling pathway	24	27	7.79e-04
GO:BP	GO:0032870	cellular response to hormone stimulus	262	433	7.82e-04
GO:BP	GO:0043542	endothelial cell migration	115	174	8.14e-04
GO:BP	GO:0006836	neurotransmitter transport	92	135	8.15e-04
GO:BP	GO:0002761	regulation of myeloid leukocyte differentiation	58	79	8.16e-04
GO:BP	GO:0071375	cellular response to peptide hormone stimulus	148	231	8.16e-04
GO:BP	GO:0009410	response to xenobiotic stimulus	172	273	8.17e-04
GO:BP	GO:0034764	positive regulation of transmembrane transport	89	130	8.22e-04
GO:BP	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	86	125	8.28e-04
GO:BP	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	66	92	8.36e-04
GO:BP	GO:0051282	regulation of sequestering of calcium ion	66	92	8.36e-04
GO:BP	GO:0001759	organ induction	15	15	8.36e-04
GO:BP	GO:0022604	regulation of cell morphogenesis	126	193	8.37e-04
GO:BP	GO:0010001	glial cell differentiation	119	181	8.45e-04
GO:BP	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	119	181	8.45e-04
GO:BP	GO:0060606	tube closure	61	84	8.84e-04
GO:BP	GO:0035270	endocrine system development	61	84	8.84e-04
GO:BP	GO:0010876	lipid localization	186	298	8.84e-04
GO:BP	GO:0043434	response to peptide hormone	195	314	8.99e-04
GO:BP	GO:0051129	negative regulation of cellular component organization	329	555	9.01e-04
GO:BP	GO:0051963	regulation of synapse assembly	56	76	9.06e-04
GO:BP	GO:1901890	positive regulation of cell junction assembly	56	76	9.06e-04
GO:BP	GO:0060914	heart formation	26	30	9.27e-04
GO:BP	GO:0002791	regulation of peptide secretion	90	132	9.27e-04
GO:BP	GO:0042475	odontogenesis of dentin-containing tooth	42	54	9.55e-04
GO:BP	GO:0055117	regulation of cardiac muscle contraction	49	65	9.86e-04
GO:BP	GO:0060079	excitatory postsynaptic potential	49	65	9.86e-04
GO:BP	GO:0033674	positive regulation of kinase activity	128	197	9.95e-04
GO:BP	GO:0051047	positive regulation of secretion	132	204	1.02e-03
GO:BP	GO:0030031	cell projection assembly	269	447	1.03e-03
GO:BP	GO:1901652	response to peptide	225	368	1.03e-03
GO:BP	GO:0032924	activin receptor signaling pathway	28	33	1.04e-03
GO:BP	GO:0003156	regulation of animal organ formation	18	19	1.06e-03
GO:BP	GO:0001764	neuron migration	88	129	1.07e-03
GO:BP	GO:0001755	neural crest cell migration	38	48	1.07e-03
GO:BP	GO:0051058	negative regulation of small GTPase mediated signal transduction	38	48	1.07e-03
GO:BP	GO:0140115	export across plasma membrane	38	48	1.07e-03
GO:BP	GO:0051961	negative regulation of nervous system development	76	109	1.08e-03
GO:BP	GO:0070167	regulation of biomineral tissue development	47	62	1.08e-03
GO:BP	GO:0099504	synaptic vesicle cycle	101	151	1.08e-03
GO:BP	GO:0045766	positive regulation of angiogenesis	79	114	1.08e-03
GO:BP	GO:0003203	endocardial cushion morphogenesis	30	36	1.10e-03
GO:BP	GO:0002376	immune system process	789	1410	1.12e-03
GO:BP	GO:0046632	alpha-beta T cell differentiation	52	70	1.13e-03
GO:BP	GO:0046620	regulation of organ growth	52	70	1.13e-03
GO:BP	GO:0040008	regulation of growth	277	462	1.13e-03
GO:BP	GO:0060627	regulation of vesicle-mediated transport	228	374	1.17e-03
GO:BP	GO:0001936	regulation of endothelial cell proliferation	68	96	1.18e-03
GO:BP	GO:0055080	monoatomic cation homeostasis	243	401	1.19e-03
GO:BP	GO:0120031	plasma membrane bounded cell projection assembly	263	437	1.19e-03
GO:BP	GO:0051641	cellular localization	1428	2623	1.19e-03
GO:BP	GO:0007611	learning or memory	123	189	1.20e-03
GO:BP	GO:0001843	neural tube closure	60	83	1.20e-03
GO:BP	GO:0002027	regulation of heart rate	60	83	1.20e-03
GO:BP	GO:0070374	positive regulation of ERK1 and ERK2 cascade	77	111	1.24e-03
GO:BP	GO:0043066	negative regulation of apoptotic process	363	619	1.24e-03
GO:BP	GO:2000181	negative regulation of blood vessel morphogenesis	50	67	1.25e-03
GO:BP	GO:0051588	regulation of neurotransmitter transport	50	67	1.25e-03
GO:BP	GO:1901343	negative regulation of vasculature development	50	67	1.25e-03
GO:BP	GO:0014896	muscle hypertrophy	55	75	1.25e-03
GO:BP	GO:0050867	positive regulation of cell activation	131	203	1.25e-03
GO:BP	GO:0045927	positive regulation of growth	120	184	1.26e-03
GO:BP	GO:0046928	regulation of neurotransmitter secretion	43	56	1.27e-03
GO:BP	GO:2000628	regulation of miRNA metabolic process	53	72	1.42e-03
GO:BP	GO:0014902	myotube differentiation	61	85	1.47e-03
GO:BP	GO:1902414	protein localization to cell junction	61	85	1.47e-03
GO:BP	GO:0060563	neuroepithelial cell differentiation	25	29	1.48e-03
GO:BP	GO:0007520	myoblast fusion	25	29	1.48e-03
GO:BP	GO:0090497	mesenchymal cell migration	39	50	1.49e-03
GO:BP	GO:0023019	signal transduction involved in regulation of gene expression	14	14	1.50e-03
GO:BP	GO:0009991	response to extracellular stimulus	229	377	1.51e-03
GO:BP	GO:0090276	regulation of peptide hormone secretion	88	130	1.57e-03
GO:BP	GO:0046888	negative regulation of hormone secretion	37	47	1.58e-03
GO:BP	GO:0031667	response to nutrient levels	216	354	1.61e-03
GO:BP	GO:1905207	regulation of cardiocyte differentiation	20	22	1.61e-03
GO:BP	GO:0048333	mesodermal cell differentiation	20	22	1.61e-03
GO:BP	GO:1903779	regulation of cardiac conduction	20	22	1.61e-03
GO:BP	GO:1902284	neuron projection extension involved in neuron projection guidance	27	32	1.63e-03
GO:BP	GO:0048846	axon extension involved in axon guidance	27	32	1.63e-03
GO:BP	GO:0086002	cardiac muscle cell action potential involved in contraction	35	44	1.66e-03
GO:BP	GO:0002696	positive regulation of leukocyte activation	127	197	1.67e-03
GO:BP	GO:0032414	positive regulation of ion transmembrane transporter activity	44	58	1.70e-03
GO:BP	GO:0010812	negative regulation of cell-substrate adhesion	33	41	1.71e-03
GO:BP	GO:0006814	sodium ion transport	92	137	1.71e-03
GO:BP	GO:0048168	regulation of neuronal synaptic plasticity	31	38	1.72e-03
GO:BP	GO:0048013	ephrin receptor signaling pathway	31	38	1.72e-03
GO:BP	GO:0000082	G1/S transition of mitotic cell cycle	120	185	1.72e-03
GO:BP	GO:0007613	memory	62	87	1.74e-03
GO:BP	GO:0014897	striated muscle hypertrophy	54	74	1.74e-03
GO:BP	GO:0016525	negative regulation of angiogenesis	49	66	1.76e-03
GO:BP	GO:0018105	peptidyl-serine phosphorylation	106	161	1.78e-03
GO:BP	GO:0001816	cytokine production	264	441	1.82e-03
GO:BP	GO:0031099	regeneration	96	144	1.83e-03
GO:BP	GO:0050890	cognition	136	213	1.83e-03
GO:BP	GO:0007009	plasma membrane organization	74	107	1.89e-03
GO:BP	GO:1903706	regulation of hemopoiesis	161	257	1.91e-03
GO:BP	GO:0043535	regulation of blood vessel endothelial cell migration	52	71	1.97e-03
GO:BP	GO:0090087	regulation of peptide transport	90	134	1.97e-03
GO:BP	GO:0072089	stem cell proliferation	60	84	1.99e-03
GO:BP	GO:0043500	muscle adaptation	63	89	2.08e-03
GO:BP	GO:0010595	positive regulation of endothelial cell migration	63	89	2.08e-03
GO:BP	GO:0051246	regulation of protein metabolic process	884	1595	2.08e-03
GO:BP	GO:0006470	protein dephosphorylation	115	177	2.11e-03
GO:BP	GO:0006869	lipid transport	163	261	2.16e-03
GO:BP	GO:0007266	Rho protein signal transduction	75	109	2.18e-03
GO:BP	GO:0045685	regulation of glial cell differentiation	38	49	2.18e-03
GO:BP	GO:1903053	regulation of extracellular matrix organization	38	49	2.18e-03
GO:BP	GO:0099175	regulation of postsynapse organization	58	81	2.28e-03
GO:BP	GO:1904064	positive regulation of cation transmembrane transport	58	81	2.28e-03
GO:BP	GO:0060350	endochondral bone morphogenesis	36	46	2.34e-03
GO:BP	GO:0097120	receptor localization to synapse	36	46	2.34e-03
GO:BP	GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway	24	28	2.38e-03
GO:BP	GO:0001817	regulation of cytokine production	261	437	2.39e-03
GO:BP	GO:0009952	anterior/posterior pattern specification	82	121	2.41e-03
GO:BP	GO:0003300	cardiac muscle hypertrophy	53	73	2.43e-03
GO:BP	GO:0051208	sequestering of calcium ion	67	96	2.49e-03
GO:BP	GO:0048813	dendrite morphogenesis	76	111	2.49e-03
GO:BP	GO:0035023	regulation of Rho protein signal transduction	48	65	2.50e-03
GO:BP	GO:0010644	cell communication by electrical coupling	26	31	2.56e-03
GO:BP	GO:0071634	regulation of transforming growth factor beta production	26	31	2.56e-03
GO:BP	GO:0050900	leukocyte migration	125	195	2.57e-03
GO:BP	GO:0018209	peptidyl-serine modification	110	169	2.57e-03
GO:BP	GO:0050795	regulation of behavior	32	40	2.58e-03
GO:BP	GO:0055006	cardiac cell development	56	78	2.58e-03
GO:BP	GO:0071868	cellular response to monoamine stimulus	28	34	2.64e-03
GO:BP	GO:0071870	cellular response to catecholamine stimulus	28	34	2.64e-03
GO:BP	GO:0061037	negative regulation of cartilage development	19	21	2.68e-03
GO:BP	GO:0014912	negative regulation of smooth muscle cell migration	19	21	2.68e-03
GO:BP	GO:0046631	alpha-beta T cell activation	62	88	2.81e-03
GO:BP	GO:0043547	positive regulation of GTPase activity	77	113	2.83e-03
GO:BP	GO:0045598	regulation of fat cell differentiation	65	93	2.86e-03
GO:BP	GO:0050680	negative regulation of epithelial cell proliferation	68	98	2.89e-03
GO:BP	GO:0050768	negative regulation of neurogenesis	71	103	2.89e-03
GO:BP	GO:0033993	response to lipid	335	573	2.91e-03
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	689	1231	2.92e-03
GO:BP	GO:0019935	cyclic-nucleotide-mediated signaling	39	51	2.93e-03
GO:BP	GO:1901653	cellular response to peptide	169	273	3.01e-03
GO:BP	GO:0009725	response to hormone	355	610	3.06e-03
GO:BP	GO:0140747	regulation of ncRNA transcription	57	80	3.10e-03
GO:BP	GO:2001257	regulation of cation channel activity	49	67	3.10e-03
GO:BP	GO:0060977	coronary vasculature morphogenesis	16	17	3.13e-03
GO:BP	GO:0034505	tooth mineralization	16	17	3.13e-03
GO:BP	GO:0003215	cardiac right ventricle morphogenesis	16	17	3.13e-03
GO:BP	GO:0033135	regulation of peptidyl-serine phosphorylation	60	85	3.21e-03
GO:BP	GO:0071396	cellular response to lipid	233	388	3.24e-03
GO:BP	GO:0071496	cellular response to external stimulus	166	268	3.24e-03
GO:BP	GO:0001890	placenta development	75	110	3.25e-03
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	690	1234	3.30e-03
GO:BP	GO:0032878	regulation of establishment or maintenance of cell polarity	21	24	3.33e-03
GO:BP	GO:0003401	axis elongation	21	24	3.33e-03
GO:BP	GO:1905332	positive regulation of morphogenesis of an epithelium	21	24	3.33e-03
GO:BP	GO:0033036	macromolecule localization	1257	2309	3.34e-03
GO:BP	GO:0019229	regulation of vasoconstriction	33	42	3.70e-03
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	497	874	3.70e-03
GO:BP	GO:0010927	cellular component assembly involved in morphogenesis	73	107	3.78e-03
GO:BP	GO:0010586	miRNA metabolic process	61	87	3.79e-03
GO:BP	GO:0001508	action potential	70	102	3.81e-03
GO:BP	GO:0120162	positive regulation of cold-induced thermogenesis	50	69	3.81e-03
GO:BP	GO:0099643	signal release from synapse	70	102	3.81e-03
GO:BP	GO:0007269	neurotransmitter secretion	70	102	3.81e-03
GO:BP	GO:0060021	roof of mouth development	50	69	3.81e-03
GO:BP	GO:0043534	blood vessel endothelial cell migration	64	92	3.81e-03
GO:BP	GO:0021536	diencephalon development	31	39	3.87e-03
GO:BP	GO:0003006	developmental process involved in reproduction	334	573	3.88e-03
GO:BP	GO:0035249	synaptic transmission, glutamatergic	45	61	3.92e-03
GO:BP	GO:0001656	metanephros development	45	61	3.92e-03
GO:BP	GO:1903532	positive regulation of secretion by cell	123	193	3.92e-03
GO:BP	GO:0048662	negative regulation of smooth muscle cell proliferation	29	36	3.99e-03
GO:BP	GO:0071869	response to catecholamine	29	36	3.99e-03
GO:BP	GO:0071867	response to monoamine	29	36	3.99e-03
GO:BP	GO:0097306	cellular response to alcohol	53	74	4.02e-03
GO:BP	GO:0002792	negative regulation of peptide secretion	27	33	4.05e-03
GO:BP	GO:2000630	positive regulation of miRNA metabolic process	38	50	4.22e-03
GO:BP	GO:0010660	regulation of muscle cell apoptotic process	38	50	4.22e-03
GO:BP	GO:0048008	platelet-derived growth factor receptor signaling pathway	38	50	4.22e-03
GO:BP	GO:0010977	negative regulation of neuron projection development	74	109	4.24e-03
GO:BP	GO:0051250	negative regulation of lymphocyte activation	59	84	4.31e-03
GO:BP	GO:0051048	negative regulation of secretion	71	104	4.32e-03
GO:BP	GO:0008543	fibroblast growth factor receptor signaling pathway	43	58	4.39e-03
GO:BP	GO:0002028	regulation of sodium ion transport	43	58	4.39e-03
GO:BP	GO:0055082	intracellular chemical homeostasis	286	486	4.44e-03
GO:BP	GO:1902547	regulation of cellular response to vascular endothelial growth factor stimulus	18	20	4.46e-03
GO:BP	GO:2000116	regulation of cysteine-type endopeptidase activity	81	121	4.50e-03
GO:BP	GO:0002067	glandular epithelial cell differentiation	36	47	4.63e-03
GO:BP	GO:0086001	cardiac muscle cell action potential	46	63	4.88e-03
GO:BP	GO:0032411	positive regulation of transporter activity	46	63	4.88e-03
GO:BP	GO:0036302	atrioventricular canal development	12	12	4.89e-03
GO:BP	GO:0032332	positive regulation of chondrocyte differentiation	12	12	4.89e-03
GO:BP	GO:0099505	regulation of presynaptic membrane potential	12	12	4.89e-03
GO:BP	GO:0048871	multicellular organismal-level homeostasis	313	536	4.89e-03
GO:BP	GO:0008360	regulation of cell shape	72	106	4.89e-03
GO:BP	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	12	12	4.89e-03
GO:BP	GO:0007405	neuroblast proliferation	41	55	4.89e-03
GO:BP	GO:0045651	positive regulation of macrophage differentiation	12	12	4.89e-03
GO:BP	GO:0010657	muscle cell apoptotic process	41	55	4.89e-03
GO:BP	GO:0038066	p38MAPK cascade	34	44	4.99e-03
GO:BP	GO:0002042	cell migration involved in sprouting angiogenesis	34	44	4.99e-03
GO:BP	GO:1902895	positive regulation of miRNA transcription	34	44	4.99e-03
GO:BP	GO:0034103	regulation of tissue remodeling	34	44	4.99e-03
GO:BP	GO:2000177	regulation of neural precursor cell proliferation	49	68	5.20e-03
GO:BP	GO:0030162	regulation of proteolysis	247	416	5.29e-03
GO:BP	GO:0032331	negative regulation of chondrocyte differentiation	15	16	5.36e-03
GO:BP	GO:0001709	cell fate determination	20	23	5.36e-03
GO:BP	GO:0043537	negative regulation of blood vessel endothelial cell migration	20	23	5.36e-03
GO:BP	GO:0050919	negative chemotaxis	32	41	5.36e-03
GO:BP	GO:0070168	negative regulation of biomineral tissue development	15	16	5.36e-03
GO:BP	GO:0061383	trabecula morphogenesis	32	41	5.36e-03
GO:BP	GO:0031128	developmental induction	20	23	5.36e-03
GO:BP	GO:0014888	striated muscle adaptation	32	41	5.36e-03
GO:BP	GO:0060037	pharyngeal system development	20	23	5.36e-03
GO:BP	GO:0045669	positive regulation of osteoblast differentiation	39	52	5.42e-03
GO:BP	GO:0021675	nerve development	44	60	5.42e-03
GO:BP	GO:0051254	positive regulation of RNA metabolic process	751	1354	5.54e-03
GO:BP	GO:0030282	bone mineralization	55	78	5.62e-03
GO:BP	GO:0051480	regulation of cytosolic calcium ion concentration	30	38	5.72e-03
GO:BP	GO:0042752	regulation of circadian rhythm	61	88	5.78e-03
GO:BP	GO:0030099	myeloid cell differentiation	178	292	5.78e-03
GO:BP	GO:0060291	long-term synaptic potentiation	47	65	5.89e-03
GO:BP	GO:0003209	cardiac atrium morphogenesis	22	26	5.90e-03
GO:BP	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	22	26	5.90e-03
GO:BP	GO:0046651	lymphocyte proliferation	98	151	5.93e-03
GO:BP	GO:0086091	regulation of heart rate by cardiac conduction	28	35	5.97e-03
GO:BP	GO:0019933	cAMP-mediated signaling	28	35	5.97e-03
GO:BP	GO:0090278	negative regulation of peptide hormone secretion	26	32	6.11e-03
GO:BP	GO:0010656	negative regulation of muscle cell apoptotic process	26	32	6.11e-03
GO:BP	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	24	29	6.11e-03
GO:BP	GO:0010837	regulation of keratinocyte proliferation	26	32	6.11e-03
GO:BP	GO:0021954	central nervous system neuron development	42	57	6.11e-03
GO:BP	GO:0071604	transforming growth factor beta production	26	32	6.11e-03
GO:BP	GO:0060041	retina development in camera-type eye	71	105	6.30e-03
GO:BP	GO:0043068	positive regulation of programmed cell death	231	388	6.31e-03
GO:BP	GO:0045859	regulation of protein kinase activity	200	332	6.36e-03
GO:BP	GO:0030856	regulation of epithelial cell differentiation	68	100	6.44e-03
GO:BP	GO:0035725	sodium ion transmembrane transport	65	95	6.55e-03
GO:BP	GO:0016311	dephosphorylation	144	232	6.55e-03
GO:BP	GO:0010811	positive regulation of cell-substrate adhesion	65	95	6.55e-03
GO:BP	GO:0050866	negative regulation of cell activation	78	117	6.59e-03
GO:BP	GO:0035019	somatic stem cell population maintenance	35	46	6.59e-03
GO:BP	GO:0006950	response to stress	1373	2540	6.68e-03
GO:BP	GO:0034109	homotypic cell-cell adhesion	48	67	7.09e-03
GO:BP	GO:0001892	embryonic placenta development	48	67	7.09e-03
GO:BP	GO:0030217	T cell differentiation	116	183	7.20e-03
GO:BP	GO:0045665	negative regulation of neuron differentiation	33	43	7.26e-03
GO:BP	GO:0032944	regulation of mononuclear cell proliferation	79	119	7.35e-03
GO:BP	GO:0062009	secondary palate development	17	19	7.35e-03
GO:BP	GO:0055013	cardiac muscle cell development	51	72	7.37e-03
GO:BP	GO:0045995	regulation of embryonic development	51	72	7.37e-03
GO:BP	GO:0002695	negative regulation of leukocyte activation	66	97	7.45e-03
GO:BP	GO:0032943	mononuclear cell proliferation	101	157	7.54e-03
GO:BP	GO:0051279	regulation of release of sequestered calcium ion into cytosol	43	59	7.54e-03
GO:BP	GO:0046849	bone remodeling	43	59	7.54e-03
GO:BP	GO:0045621	positive regulation of lymphocyte differentiation	57	82	7.63e-03
GO:BP	GO:0010633	negative regulation of epithelial cell migration	38	51	7.67e-03
GO:BP	GO:0045936	negative regulation of phosphate metabolic process	175	288	7.70e-03
GO:BP	GO:0060326	cell chemotaxis	98	152	8.05e-03
GO:BP	GO:0032101	regulation of response to external stimulus	375	654	8.47e-03
GO:BP	GO:0062013	positive regulation of small molecule metabolic process	67	99	8.47e-03
GO:BP	GO:0050670	regulation of lymphocyte proliferation	77	116	8.52e-03
GO:BP	GO:0044843	cell cycle G1/S phase transition	127	203	8.58e-03
GO:BP	GO:0021700	developmental maturation	127	203	8.58e-03
GO:BP	GO:0071300	cellular response to retinoic acid	36	48	8.60e-03
GO:BP	GO:0002021	response to dietary excess	19	22	8.64e-03
GO:BP	GO:0097150	neuronal stem cell population maintenance	19	22	8.64e-03
GO:BP	GO:0031623	receptor internalization	61	89	8.77e-03
GO:BP	GO:0045637	regulation of myeloid cell differentiation	88	135	8.85e-03
GO:BP	GO:0070661	leukocyte proliferation	111	175	8.86e-03
GO:BP	GO:0043114	regulation of vascular permeability	27	34	8.99e-03
GO:BP	GO:0003230	cardiac atrium development	27	34	8.99e-03
GO:BP	GO:0060571	morphogenesis of an epithelial fold	14	15	9.15e-03
GO:BP	GO:0014047	glutamate secretion	14	15	9.15e-03
GO:BP	GO:0071636	positive regulation of transforming growth factor beta production	14	15	9.15e-03
GO:BP	GO:0055012	ventricular cardiac muscle cell differentiation	14	15	9.15e-03
GO:BP	GO:0035567	non-canonical Wnt signaling pathway	44	61	9.19e-03
GO:BP	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	44	61	9.19e-03
GO:BP	GO:0030857	negative regulation of epithelial cell differentiation	25	31	9.28e-03
GO:BP	GO:1900744	regulation of p38MAPK cascade	25	31	9.28e-03
GO:BP	GO:0070663	regulation of leukocyte proliferation	85	130	9.28e-03
GO:BP	GO:0090049	regulation of cell migration involved in sprouting angiogenesis	25	31	9.28e-03
GO:BP	GO:1903351	cellular response to dopamine	25	31	9.28e-03
GO:BP	GO:0060391	positive regulation of SMAD protein signal transduction	25	31	9.28e-03
GO:BP	GO:0002274	myeloid leukocyte activation	78	118	9.29e-03
GO:BP	GO:0009913	epidermal cell differentiation	78	118	9.29e-03
GO:BP	GO:0048483	autonomic nervous system development	23	28	9.40e-03
GO:BP	GO:0048841	regulation of axon extension involved in axon guidance	23	28	9.40e-03
GO:BP	GO:0010563	negative regulation of phosphorus metabolic process	175	289	9.41e-03
GO:BP	GO:0045639	positive regulation of myeloid cell differentiation	47	66	9.59e-03
GO:BP	GO:0022408	negative regulation of cell-cell adhesion	75	113	9.72e-03
GO:BP	GO:0043254	regulation of protein-containing complex assembly	196	327	9.73e-03
GO:BP	GO:0051928	positive regulation of calcium ion transport	50	71	9.88e-03
GO:BP	GO:1903038	negative regulation of leukocyte cell-cell adhesion	50	71	9.88e-03
GO:BP	GO:0001819	positive regulation of cytokine production	157	257	9.96e-03
GO:BP	GO:0007229	integrin-mediated signaling pathway	59	86	1.00e-02
GO:BP	GO:0071887	leukocyte apoptotic process	53	76	1.00e-02
GO:BP	GO:0048608	reproductive structure development	126	202	1.03e-02
GO:BP	GO:0045123	cellular extravasation	32	42	1.04e-02
GO:BP	GO:0006873	intracellular monoatomic ion homeostasis	214	360	1.05e-02
GO:BP	GO:0045862	positive regulation of proteolysis	150	245	1.12e-02
GO:BP	GO:0042098	T cell proliferation	73	110	1.13e-02
GO:BP	GO:0030177	positive regulation of Wnt signaling pathway	73	110	1.13e-02
GO:BP	GO:0043502	regulation of muscle adaptation	48	68	1.14e-02
GO:BP	GO:0055002	striated muscle cell development	48	68	1.14e-02
GO:BP	GO:0030003	intracellular monoatomic cation homeostasis	211	355	1.14e-02
GO:BP	GO:0050922	negative regulation of chemotaxis	30	39	1.15e-02
GO:BP	GO:0003014	renal system process	51	73	1.16e-02
GO:BP	GO:0034763	negative regulation of transmembrane transport	57	83	1.16e-02
GO:BP	GO:2001056	positive regulation of cysteine-type endopeptidase activity	57	83	1.16e-02
GO:BP	GO:0010976	positive regulation of neuron projection development	84	129	1.17e-02
GO:BP	GO:0008217	regulation of blood pressure	70	105	1.17e-02
GO:BP	GO:0042310	vasoconstriction	40	55	1.18e-02
GO:BP	GO:0038094	Fc-gamma receptor signaling pathway	16	18	1.20e-02
GO:BP	GO:0051968	positive regulation of synaptic transmission, glutamatergic	16	18	1.20e-02
GO:BP	GO:1903319	positive regulation of protein maturation	16	18	1.20e-02
GO:BP	GO:0055093	response to hyperoxia	16	18	1.20e-02
GO:BP	GO:0045649	regulation of macrophage differentiation	16	18	1.20e-02
GO:BP	GO:0003228	atrial cardiac muscle tissue development	16	18	1.20e-02
GO:BP	GO:1900746	regulation of vascular endothelial growth factor signaling pathway	16	18	1.20e-02
GO:BP	GO:0002763	positive regulation of myeloid leukocyte differentiation	28	36	1.24e-02
GO:BP	GO:0060443	mammary gland morphogenesis	28	36	1.24e-02
GO:BP	GO:0120032	regulation of plasma membrane bounded cell projection assembly	100	157	1.24e-02
GO:BP	GO:0051493	regulation of cytoskeleton organization	242	412	1.25e-02
GO:BP	GO:0048675	axon extension	64	95	1.25e-02
GO:BP	GO:0071214	cellular response to abiotic stimulus	153	251	1.28e-02
GO:BP	GO:0104004	cellular response to environmental stimulus	153	251	1.28e-02
GO:BP	GO:0008366	axon ensheathment	78	119	1.30e-02
GO:BP	GO:0007272	ensheathment of neurons	78	119	1.30e-02
GO:BP	GO:0048640	negative regulation of developmental growth	58	85	1.31e-02
GO:BP	GO:0032231	regulation of actin filament bundle assembly	58	85	1.31e-02
GO:BP	GO:0060491	regulation of cell projection assembly	101	159	1.32e-02
GO:BP	GO:0022414	reproductive process	491	874	1.36e-02
GO:BP	GO:0021983	pituitary gland development	18	21	1.37e-02
GO:BP	GO:0060384	innervation	18	21	1.37e-02
GO:BP	GO:0031324	negative regulation of cellular metabolic process	1051	1934	1.37e-02
GO:BP	GO:0061458	reproductive system development	127	205	1.38e-02
GO:BP	GO:0043412	macromolecule modification	1341	2489	1.39e-02
GO:BP	GO:0001937	negative regulation of endothelial cell proliferation	24	30	1.39e-02
GO:BP	GO:0046676	negative regulation of insulin secretion	24	30	1.39e-02
GO:BP	GO:0048546	digestive tract morphogenesis	24	30	1.39e-02
GO:BP	GO:0048512	circadian behavior	24	30	1.39e-02
GO:BP	GO:0007616	long-term memory	24	30	1.39e-02
GO:BP	GO:0046850	regulation of bone remodeling	24	30	1.39e-02
GO:BP	GO:0050817	coagulation	94	147	1.40e-02
GO:BP	GO:0008361	regulation of cell size	94	147	1.40e-02
GO:BP	GO:1990845	adaptive thermogenesis	79	121	1.41e-02
GO:BP	GO:0071260	cellular response to mechanical stimulus	41	57	1.42e-02
GO:BP	GO:0032147	activation of protein kinase activity	41	57	1.42e-02
GO:BP	GO:0051899	membrane depolarization	41	57	1.42e-02
GO:BP	GO:0014898	cardiac muscle hypertrophy in response to stress	20	24	1.42e-02
GO:BP	GO:0003299	muscle hypertrophy in response to stress	20	24	1.42e-02
GO:BP	GO:1990573	potassium ion import across plasma membrane	22	27	1.42e-02
GO:BP	GO:0010464	regulation of mesenchymal cell proliferation	22	27	1.42e-02
GO:BP	GO:0045124	regulation of bone resorption	20	24	1.42e-02
GO:BP	GO:0002431	Fc receptor mediated stimulatory signaling pathway	20	24	1.42e-02
GO:BP	GO:0031279	regulation of cyclase activity	22	27	1.42e-02
GO:BP	GO:0014887	cardiac muscle adaptation	20	24	1.42e-02
GO:BP	GO:0043065	positive regulation of apoptotic process	224	380	1.42e-02
GO:BP	GO:0045926	negative regulation of growth	115	184	1.44e-02
GO:BP	GO:0034446	substrate adhesion-dependent cell spreading	59	87	1.46e-02
GO:BP	GO:0030168	platelet activation	59	87	1.46e-02
GO:BP	GO:0030902	hindbrain development	69	104	1.47e-02
GO:BP	GO:0045582	positive regulation of T cell differentiation	50	72	1.52e-02
GO:BP	GO:0021533	cell differentiation in hindbrain	13	14	1.53e-02
GO:BP	GO:0043217	myelin maintenance	13	14	1.53e-02
GO:BP	GO:0010002	cardioblast differentiation	13	14	1.53e-02
GO:BP	GO:0009892	negative regulation of metabolic process	1137	2100	1.54e-02
GO:BP	GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance	10	10	1.54e-02
GO:BP	GO:0072497	mesenchymal stem cell differentiation	10	10	1.54e-02
GO:BP	GO:0045906	negative regulation of vasoconstriction	10	10	1.54e-02
GO:BP	GO:0022410	circadian sleep/wake cycle process	10	10	1.54e-02
GO:BP	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	10	10	1.54e-02
GO:BP	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	10	10	1.54e-02
GO:BP	GO:0030431	sleep	10	10	1.54e-02
GO:BP	GO:0043549	regulation of kinase activity	211	357	1.59e-02
GO:BP	GO:1903531	negative regulation of secretion by cell	63	94	1.59e-02
GO:BP	GO:0007596	blood coagulation	92	144	1.59e-02
GO:BP	GO:0050918	positive chemotaxis	29	38	1.62e-02
GO:BP	GO:0002066	columnar/cuboidal epithelial cell development	29	38	1.62e-02
GO:BP	GO:0014074	response to purine-containing compound	70	106	1.62e-02
GO:BP	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	29	38	1.62e-02
GO:BP	GO:0045103	intermediate filament-based process	29	38	1.62e-02
GO:BP	GO:0001706	endoderm formation	34	46	1.67e-02
GO:BP	GO:0033043	regulation of organelle organization	532	953	1.68e-02
GO:BP	GO:0030278	regulation of ossification	54	79	1.72e-02
GO:BP	GO:0010038	response to metal ion	151	249	1.76e-02
GO:BP	GO:0051347	positive regulation of transferase activity	156	258	1.76e-02
GO:BP	GO:0007605	sensory perception of sound	64	96	1.77e-02
GO:BP	GO:0008038	neuron recognition	27	35	1.78e-02
GO:BP	GO:0001933	negative regulation of protein phosphorylation	137	224	1.78e-02
GO:BP	GO:0042593	glucose homeostasis	106	169	1.80e-02
GO:BP	GO:0051223	regulation of protein transport	193	325	1.81e-02
GO:BP	GO:0042733	embryonic digit morphogenesis	37	51	1.82e-02
GO:BP	GO:0007599	hemostasis	94	148	1.84e-02
GO:BP	GO:0009880	embryonic pattern specification	32	43	1.89e-02
GO:BP	GO:0042129	regulation of T cell proliferation	58	86	1.91e-02
GO:BP	GO:0019725	cellular homeostasis	323	564	1.91e-02
GO:BP	GO:0098884	postsynaptic neurotransmitter receptor internalization	15	17	1.92e-02
GO:BP	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	15	17	1.92e-02
GO:BP	GO:0051590	positive regulation of neurotransmitter transport	15	17	1.92e-02
GO:BP	GO:0010954	positive regulation of protein processing	15	17	1.92e-02
GO:BP	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis	15	17	1.92e-02
GO:BP	GO:0007622	rhythmic behavior	25	32	1.92e-02
GO:BP	GO:0140239	postsynaptic endocytosis	15	17	1.92e-02
GO:BP	GO:0048169	regulation of long-term neuronal synaptic plasticity	15	17	1.92e-02
GO:BP	GO:1903350	response to dopamine	25	32	1.92e-02
GO:BP	GO:0060711	labyrinthine layer development	25	32	1.92e-02
GO:BP	GO:0007612	learning	72	110	1.95e-02
GO:BP	GO:0030879	mammary gland development	65	98	1.95e-02
GO:BP	GO:0001701	in utero embryonic development	196	331	1.98e-02
GO:BP	GO:0110053	regulation of actin filament organization	130	212	1.98e-02
GO:BP	GO:0030239	myofibril assembly	46	66	2.00e-02
GO:BP	GO:0106027	neuron projection organization	49	71	2.00e-02
GO:BP	GO:0035710	CD4-positive, alpha-beta T cell activation	46	66	2.00e-02
GO:BP	GO:0042552	myelination	76	117	2.01e-02
GO:BP	GO:0061384	heart trabecula morphogenesis	23	29	2.04e-02
GO:BP	GO:0042326	negative regulation of phosphorylation	145	239	2.04e-02
GO:BP	GO:0097106	postsynaptic density organization	23	29	2.04e-02
GO:BP	GO:0042491	inner ear auditory receptor cell differentiation	23	29	2.04e-02
GO:BP	GO:0086019	cell-cell signaling involved in cardiac conduction	23	29	2.04e-02
GO:BP	GO:0031102	neuron projection regeneration	35	48	2.05e-02
GO:BP	GO:0030500	regulation of bone mineralization	35	48	2.05e-02
GO:BP	GO:0048286	lung alveolus development	30	40	2.09e-02
GO:BP	GO:1902905	positive regulation of supramolecular fiber organization	88	138	2.09e-02
GO:BP	GO:0031281	positive regulation of cyclase activity	17	20	2.11e-02
GO:BP	GO:2000114	regulation of establishment of cell polarity	17	20	2.11e-02
GO:BP	GO:0048710	regulation of astrocyte differentiation	17	20	2.11e-02
GO:BP	GO:0048730	epidermis morphogenesis	17	20	2.11e-02
GO:BP	GO:0043588	skin development	109	175	2.12e-02
GO:BP	GO:0048806	genitalia development	21	26	2.13e-02
GO:BP	GO:1903055	positive regulation of extracellular matrix organization	21	26	2.13e-02
GO:BP	GO:0007212	dopamine receptor signaling pathway	21	26	2.13e-02
GO:BP	GO:1902656	calcium ion import into cytosol	21	26	2.13e-02
GO:BP	GO:0010765	positive regulation of sodium ion transport	19	23	2.15e-02
GO:BP	GO:0010827	regulation of glucose transmembrane transport	38	53	2.15e-02
GO:BP	GO:0003416	endochondral bone growth	19	23	2.15e-02
GO:BP	GO:0072012	glomerulus vasculature development	19	23	2.15e-02
GO:BP	GO:1904752	regulation of vascular associated smooth muscle cell migration	19	23	2.15e-02
GO:BP	GO:0043367	CD4-positive, alpha-beta T cell differentiation	38	53	2.15e-02
GO:BP	GO:0045834	positive regulation of lipid metabolic process	56	83	2.15e-02
GO:BP	GO:0045761	regulation of adenylate cyclase activity	19	23	2.15e-02
GO:BP	GO:0019216	regulation of lipid metabolic process	132	216	2.15e-02
GO:BP	GO:0010469	regulation of signaling receptor activity	41	58	2.24e-02
GO:BP	GO:0048706	embryonic skeletal system development	50	73	2.26e-02
GO:BP	GO:0048145	regulation of fibroblast proliferation	50	73	2.26e-02
GO:BP	GO:0097581	lamellipodium organization	50	73	2.26e-02
GO:BP	GO:0033500	carbohydrate homeostasis	106	170	2.27e-02
GO:BP	GO:0097061	dendritic spine organization	44	63	2.27e-02
GO:BP	GO:1903115	regulation of actin filament-based movement	28	37	2.29e-02
GO:BP	GO:0045104	intermediate filament cytoskeleton organization	28	37	2.29e-02
GO:BP	GO:0045747	positive regulation of Notch signaling pathway	28	37	2.29e-02
GO:BP	GO:0010658	striated muscle cell apoptotic process	28	37	2.29e-02
GO:BP	GO:0001818	negative regulation of cytokine production	102	163	2.30e-02
GO:BP	GO:0010761	fibroblast migration	36	50	2.48e-02
GO:BP	GO:0048814	regulation of dendrite morphogenesis	36	50	2.48e-02
GO:BP	GO:0042490	mechanoreceptor differentiation	36	50	2.48e-02
GO:BP	GO:0062012	regulation of small molecule metabolic process	140	231	2.48e-02
GO:BP	GO:1901655	cellular response to ketone	54	80	2.50e-02
GO:BP	GO:0032535	regulation of cellular component size	171	287	2.51e-02
GO:BP	GO:0008104	protein localization	1081	2000	2.51e-02
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	397	704	2.51e-02
GO:BP	GO:0010662	regulation of striated muscle cell apoptotic process	26	34	2.52e-02
GO:BP	GO:0071895	odontoblast differentiation	12	13	2.52e-02
GO:BP	GO:0010659	cardiac muscle cell apoptotic process	26	34	2.52e-02
GO:BP	GO:0048665	neuron fate specification	12	13	2.52e-02
GO:BP	GO:0099084	postsynaptic specialization organization	26	34	2.52e-02
GO:BP	GO:0046579	positive regulation of Ras protein signal transduction	12	13	2.52e-02
GO:BP	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	12	13	2.52e-02
GO:BP	GO:0060841	venous blood vessel development	12	13	2.52e-02
GO:BP	GO:0000003	reproduction	492	882	2.52e-02
GO:BP	GO:0030033	microvillus assembly	12	13	2.52e-02
GO:BP	GO:0035315	hair cell differentiation	26	34	2.52e-02
GO:BP	GO:0009954	proximal/distal pattern formation	12	13	2.52e-02
GO:BP	GO:0001956	positive regulation of neurotransmitter secretion	12	13	2.52e-02
GO:BP	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	68	104	2.54e-02
GO:BP	GO:0070509	calcium ion import	39	55	2.54e-02
GO:BP	GO:0003073	regulation of systemic arterial blood pressure	39	55	2.54e-02
GO:BP	GO:0001954	positive regulation of cell-matrix adhesion	31	42	2.58e-02
GO:BP	GO:0048146	positive regulation of fibroblast proliferation	31	42	2.58e-02
GO:BP	GO:0051966	regulation of synaptic transmission, glutamatergic	31	42	2.58e-02
GO:BP	GO:0001938	positive regulation of endothelial cell proliferation	48	70	2.58e-02
GO:BP	GO:0048661	positive regulation of smooth muscle cell proliferation	42	60	2.59e-02
GO:BP	GO:0035418	protein localization to synapse	42	60	2.59e-02
GO:BP	GO:0030316	osteoclast differentiation	45	65	2.59e-02
GO:BP	GO:0001942	hair follicle development	45	65	2.59e-02
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	1055	1951	2.60e-02
GO:BP	GO:0110020	regulation of actomyosin structure organization	58	87	2.65e-02
GO:BP	GO:0051147	regulation of muscle cell differentiation	76	118	2.65e-02
GO:BP	GO:0050714	positive regulation of protein secretion	65	99	2.67e-02
GO:BP	GO:0046629	gamma-delta T cell activation	9	9	2.68e-02
GO:BP	GO:2000288	positive regulation of myoblast proliferation	9	9	2.68e-02
GO:BP	GO:0002024	diet induced thermogenesis	9	9	2.68e-02
GO:BP	GO:0050802	circadian sleep/wake cycle, sleep	9	9	2.68e-02
GO:BP	GO:0010838	positive regulation of keratinocyte proliferation	9	9	2.68e-02
GO:BP	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	9	9	2.68e-02
GO:BP	GO:0032060	bleb assembly	9	9	2.68e-02
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	540	973	2.68e-02
GO:BP	GO:2000739	regulation of mesenchymal stem cell differentiation	9	9	2.68e-02
GO:BP	GO:0048845	venous blood vessel morphogenesis	9	9	2.68e-02
GO:BP	GO:0001768	establishment of T cell polarity	9	9	2.68e-02
GO:BP	GO:0032906	transforming growth factor beta2 production	9	9	2.68e-02
GO:BP	GO:0032909	regulation of transforming growth factor beta2 production	9	9	2.68e-02
GO:BP	GO:0051643	endoplasmic reticulum localization	9	9	2.68e-02
GO:BP	GO:0061626	pharyngeal arch artery morphogenesis	9	9	2.68e-02
GO:BP	GO:0010665	regulation of cardiac muscle cell apoptotic process	24	31	2.72e-02
GO:BP	GO:0060688	regulation of morphogenesis of a branching structure	24	31	2.72e-02
GO:BP	GO:0034405	response to fluid shear stress	24	31	2.72e-02
GO:BP	GO:0070664	negative regulation of leukocyte proliferation	34	47	2.74e-02
GO:BP	GO:0014743	regulation of muscle hypertrophy	34	47	2.74e-02
GO:BP	GO:0045600	positive regulation of fat cell differentiation	34	47	2.74e-02
GO:BP	GO:1903317	regulation of protein maturation	34	47	2.74e-02
GO:BP	GO:0007584	response to nutrient	73	113	2.79e-02
GO:BP	GO:0061024	membrane organization	354	625	2.81e-02
GO:BP	GO:0007179	transforming growth factor beta receptor signaling pathway	106	171	2.82e-02
GO:BP	GO:0045619	regulation of lymphocyte differentiation	81	127	2.85e-02
GO:BP	GO:0042311	vasodilation	29	39	2.86e-02
GO:BP	GO:0051965	positive regulation of synapse assembly	29	39	2.86e-02
GO:BP	GO:0035904	aorta development	37	52	2.87e-02
GO:BP	GO:1904427	positive regulation of calcium ion transmembrane transport	37	52	2.87e-02
GO:BP	GO:0070727	cellular macromolecule localization	1085	2010	2.87e-02
GO:BP	GO:0003171	atrioventricular valve development	22	28	2.92e-02
GO:BP	GO:0022405	hair cycle process	46	67	2.92e-02
GO:BP	GO:0022404	molting cycle process	46	67	2.92e-02
GO:BP	GO:0048713	regulation of oligodendrocyte differentiation	22	28	2.92e-02
GO:BP	GO:0060317	cardiac epithelial to mesenchymal transition	22	28	2.92e-02
GO:BP	GO:0044331	cell-cell adhesion mediated by cadherin	22	28	2.92e-02
GO:BP	GO:0031503	protein-containing complex localization	98	157	2.93e-02
GO:BP	GO:0086014	atrial cardiac muscle cell action potential	14	16	2.99e-02
GO:BP	GO:0086026	atrial cardiac muscle cell to AV node cell signaling	14	16	2.99e-02
GO:BP	GO:0021846	cell proliferation in forebrain	14	16	2.99e-02
GO:BP	GO:0003128	heart field specification	14	16	2.99e-02
GO:BP	GO:0086066	atrial cardiac muscle cell to AV node cell communication	14	16	2.99e-02
GO:BP	GO:1900274	regulation of phospholipase C activity	14	16	2.99e-02
GO:BP	GO:0045762	positive regulation of adenylate cyclase activity	14	16	2.99e-02
GO:BP	GO:0019827	stem cell population maintenance	90	143	3.00e-02
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	535	965	3.01e-02
GO:BP	GO:1904738	vascular associated smooth muscle cell migration	20	25	3.09e-02
GO:BP	GO:0061437	renal system vasculature development	20	25	3.09e-02
GO:BP	GO:0007435	salivary gland morphogenesis	20	25	3.09e-02
GO:BP	GO:0061440	kidney vasculature development	20	25	3.09e-02
GO:BP	GO:0098703	calcium ion import across plasma membrane	20	25	3.09e-02
GO:BP	GO:0007623	circadian rhythm	95	152	3.15e-02
GO:BP	GO:0030038	contractile actin filament bundle assembly	60	91	3.17e-02
GO:BP	GO:0043149	stress fiber assembly	60	91	3.17e-02
GO:BP	GO:0038179	neurotrophin signaling pathway	27	36	3.17e-02
GO:BP	GO:0035306	positive regulation of dephosphorylation	27	36	3.17e-02
GO:BP	GO:0060512	prostate gland morphogenesis	16	19	3.17e-02
GO:BP	GO:0098810	neurotransmitter reuptake	16	19	3.17e-02
GO:BP	GO:1990806	ligand-gated ion channel signaling pathway	16	19	3.17e-02
GO:BP	GO:0099590	neurotransmitter receptor internalization	16	19	3.17e-02
GO:BP	GO:0060740	prostate gland epithelium morphogenesis	16	19	3.17e-02
GO:BP	GO:1901201	regulation of extracellular matrix assembly	16	19	3.17e-02
GO:BP	GO:0042092	type 2 immune response	16	19	3.17e-02
GO:BP	GO:0003338	metanephros morphogenesis	16	19	3.17e-02
GO:BP	GO:0097529	myeloid leukocyte migration	71	110	3.17e-02
GO:BP	GO:0055075	potassium ion homeostasis	18	22	3.18e-02
GO:BP	GO:0030279	negative regulation of ossification	18	22	3.18e-02
GO:BP	GO:0031400	negative regulation of protein modification process	191	325	3.18e-02
GO:BP	GO:1904705	regulation of vascular associated smooth muscle cell proliferation	35	49	3.24e-02
GO:BP	GO:0018107	peptidyl-threonine phosphorylation	47	69	3.28e-02
GO:BP	GO:1990778	protein localization to cell periphery	170	287	3.34e-02
GO:BP	GO:0016239	positive regulation of macroautophagy	44	64	3.34e-02
GO:BP	GO:0050868	negative regulation of T cell activation	44	64	3.34e-02
GO:BP	GO:0050772	positive regulation of axonogenesis	44	64	3.34e-02
GO:BP	GO:0140238	presynaptic endocytosis	41	59	3.36e-02
GO:BP	GO:2000045	regulation of G1/S transition of mitotic cell cycle	88	140	3.41e-02
GO:BP	GO:0106106	cold-induced thermogenesis	72	112	3.42e-02
GO:BP	GO:1903034	regulation of response to wounding	76	119	3.45e-02
GO:BP	GO:0046683	response to organophosphorus	61	93	3.46e-02
GO:BP	GO:0010171	body morphogenesis	30	41	3.49e-02
GO:BP	GO:0045453	bone resorption	30	41	3.49e-02
GO:BP	GO:0007600	sensory perception	150	251	3.50e-02
GO:BP	GO:1902692	regulation of neuroblast proliferation	25	33	3.51e-02
GO:BP	GO:0038093	Fc receptor signaling pathway	25	33	3.51e-02
GO:BP	GO:0018210	peptidyl-threonine modification	51	76	3.58e-02
GO:BP	GO:0060996	dendritic spine development	51	76	3.58e-02
GO:BP	GO:0007219	Notch signaling pathway	89	142	3.63e-02
GO:BP	GO:0030595	leukocyte chemotaxis	69	107	3.65e-02
GO:BP	GO:0032880	regulation of protein localization	388	691	3.70e-02
GO:BP	GO:0001655	urogenital system development	33	46	3.71e-02
GO:BP	GO:0010611	regulation of cardiac muscle hypertrophy	33	46	3.71e-02
GO:BP	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	33	46	3.71e-02
GO:BP	GO:0062014	negative regulation of small molecule metabolic process	48	71	3.71e-02
GO:BP	GO:1904036	negative regulation of epithelial cell apoptotic process	33	46	3.71e-02
GO:BP	GO:0007265	Ras protein signal transduction	62	95	3.78e-02
GO:BP	GO:0051153	regulation of striated muscle cell differentiation	45	66	3.80e-02
GO:BP	GO:0006887	exocytosis	142	237	3.83e-02
GO:BP	GO:0050771	negative regulation of axonogenesis	36	51	3.83e-02
GO:BP	GO:0043266	regulation of potassium ion transport	42	61	3.85e-02
GO:BP	GO:0031668	cellular response to extracellular stimulus	132	219	3.85e-02
GO:BP	GO:0033273	response to vitamin	42	61	3.85e-02
GO:BP	GO:0002088	lens development in camera-type eye	39	56	3.87e-02
GO:BP	GO:1904019	epithelial cell apoptotic process	66	102	3.87e-02
GO:BP	GO:0052652	cyclic purine nucleotide metabolic process	23	30	3.88e-02
GO:BP	GO:0014911	positive regulation of smooth muscle cell migration	23	30	3.88e-02
GO:BP	GO:0001659	temperature homeostasis	82	130	3.93e-02
GO:BP	GO:2001222	regulation of neuron migration	28	38	3.94e-02
GO:BP	GO:0006940	regulation of smooth muscle contraction	28	38	3.94e-02
GO:BP	GO:0045668	negative regulation of osteoblast differentiation	28	38	3.94e-02
GO:BP	GO:0061005	cell differentiation involved in kidney development	28	38	3.94e-02
GO:BP	GO:0052548	regulation of endopeptidase activity	95	153	3.97e-02
GO:BP	GO:0050773	regulation of dendrite development	52	78	3.97e-02
GO:BP	GO:0046942	carboxylic acid transport	123	203	3.98e-02
GO:BP	GO:0072578	neurotransmitter-gated ion channel clustering	11	12	4.07e-02
GO:BP	GO:0045780	positive regulation of bone resorption	11	12	4.07e-02
GO:BP	GO:0048368	lateral mesoderm development	11	12	4.07e-02
GO:BP	GO:0003222	ventricular trabecula myocardium morphogenesis	11	12	4.07e-02
GO:BP	GO:0061154	endothelial tube morphogenesis	11	12	4.07e-02
GO:BP	GO:0003207	cardiac chamber formation	11	12	4.07e-02
GO:BP	GO:0055057	neuroblast division	11	12	4.07e-02
GO:BP	GO:0003159	morphogenesis of an endothelium	11	12	4.07e-02
GO:BP	GO:0030539	male genitalia development	11	12	4.07e-02
GO:BP	GO:0031669	cellular response to nutrient levels	119	196	4.12e-02
GO:BP	GO:0001558	regulation of cell growth	189	323	4.13e-02
GO:BP	GO:0038127	ERBB signaling pathway	67	104	4.16e-02
GO:BP	GO:0051651	maintenance of location in cell	105	171	4.16e-02
GO:BP	GO:0051253	negative regulation of RNA metabolic process	587	1067	4.18e-02
GO:BP	GO:0120161	regulation of cold-induced thermogenesis	71	111	4.18e-02
GO:BP	GO:1901021	positive regulation of calcium ion transmembrane transporter activity	21	27	4.18e-02
GO:BP	GO:0120033	negative regulation of plasma membrane bounded cell projection assembly	21	27	4.18e-02
GO:BP	GO:0010517	regulation of phospholipase activity	21	27	4.18e-02
GO:BP	GO:0035909	aorta morphogenesis	21	27	4.18e-02
GO:BP	GO:0031333	negative regulation of protein-containing complex assembly	75	118	4.18e-02
GO:BP	GO:0002294	CD4-positive, alpha-beta T cell differentiation involved in immune response	31	43	4.18e-02
GO:BP	GO:0030514	negative regulation of BMP signaling pathway	31	43	4.18e-02
GO:BP	GO:0042093	T-helper cell differentiation	31	43	4.18e-02
GO:BP	GO:0070570	regulation of neuron projection regeneration	21	27	4.18e-02
GO:BP	GO:0032945	negative regulation of mononuclear cell proliferation	31	43	4.18e-02
GO:BP	GO:0002293	alpha-beta T cell differentiation involved in immune response	31	43	4.18e-02
GO:BP	GO:0050672	negative regulation of lymphocyte proliferation	31	43	4.18e-02
GO:BP	GO:0002287	alpha-beta T cell activation involved in immune response	31	43	4.18e-02
GO:BP	GO:0150104	transport across blood-brain barrier	46	68	4.20e-02
GO:BP	GO:0010232	vascular transport	46	68	4.20e-02
GO:BP	GO:0060249	anatomical structure homeostasis	101	164	4.24e-02
GO:BP	GO:0001894	tissue homeostasis	101	164	4.24e-02
GO:BP	GO:0010629	negative regulation of gene expression	440	790	4.24e-02
GO:BP	GO:0060113	inner ear receptor cell differentiation	34	48	4.32e-02
GO:BP	GO:0048488	synaptic vesicle endocytosis	40	58	4.38e-02
GO:BP	GO:0033138	positive regulation of peptidyl-serine phosphorylation	40	58	4.38e-02
GO:BP	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	26	35	4.38e-02
GO:BP	GO:0034113	heterotypic cell-cell adhesion	26	35	4.38e-02
GO:BP	GO:0010508	positive regulation of autophagy	80	127	4.43e-02
GO:BP	GO:0098781	ncRNA transcription	76	120	4.47e-02
GO:BP	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	19	24	4.49e-02
GO:BP	GO:0033280	response to vitamin D	19	24	4.49e-02
GO:BP	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	19	24	4.49e-02
GO:BP	GO:0022011	myelination in peripheral nervous system	19	24	4.49e-02
GO:BP	GO:0032292	peripheral nervous system axon ensheathment	19	24	4.49e-02
GO:BP	GO:0001958	endochondral ossification	19	24	4.49e-02
GO:BP	GO:0098868	bone growth	19	24	4.49e-02
GO:BP	GO:0036075	replacement ossification	19	24	4.49e-02
GO:BP	GO:0030534	adult behavior	57	87	4.50e-02
GO:BP	GO:0042303	molting cycle	50	75	4.50e-02
GO:BP	GO:0007204	positive regulation of cytosolic calcium ion concentration	50	75	4.50e-02
GO:BP	GO:0042633	hair cycle	50	75	4.50e-02
GO:BP	GO:0097152	mesenchymal cell apoptotic process	8	8	4.56e-02
GO:BP	GO:0045187	regulation of circadian sleep/wake cycle, sleep	8	8	4.56e-02
GO:BP	GO:0036462	TRAIL-activated apoptotic signaling pathway	8	8	4.56e-02
GO:BP	GO:0071389	cellular response to mineralocorticoid stimulus	8	8	4.56e-02
GO:BP	GO:0040034	regulation of development, heterochronic	8	8	4.56e-02
GO:BP	GO:0060982	coronary artery morphogenesis	8	8	4.56e-02
GO:BP	GO:0048505	regulation of timing of cell differentiation	8	8	4.56e-02
GO:BP	GO:0048715	negative regulation of oligodendrocyte differentiation	8	8	4.56e-02
GO:BP	GO:0003190	atrioventricular valve formation	8	8	4.56e-02
GO:BP	GO:0032674	regulation of interleukin-5 production	8	8	4.56e-02
GO:BP	GO:0060896	neural plate pattern specification	8	8	4.56e-02
GO:BP	GO:0032634	interleukin-5 production	8	8	4.56e-02
GO:BP	GO:2000651	positive regulation of sodium ion transmembrane transporter activity	8	8	4.56e-02
GO:BP	GO:1900116	extracellular negative regulation of signal transduction	8	8	4.56e-02
GO:BP	GO:0099624	atrial cardiac muscle cell membrane repolarization	8	8	4.56e-02
GO:BP	GO:1900115	extracellular regulation of signal transduction	8	8	4.56e-02
GO:BP	GO:0003149	membranous septum morphogenesis	8	8	4.56e-02
GO:BP	GO:0003418	growth plate cartilage chondrocyte differentiation	8	8	4.56e-02
GO:BP	GO:0018193	peptidyl-amino acid modification	314	555	4.56e-02
GO:BP	GO:0002828	regulation of type 2 immune response	13	15	4.58e-02
GO:BP	GO:0051546	keratinocyte migration	13	15	4.58e-02
GO:BP	GO:1902932	positive regulation of alcohol biosynthetic process	13	15	4.58e-02
GO:BP	GO:0072170	metanephric tubule development	13	15	4.58e-02
GO:BP	GO:0060413	atrial septum morphogenesis	13	15	4.58e-02
GO:BP	GO:1902683	regulation of receptor localization to synapse	13	15	4.58e-02
GO:BP	GO:0070571	negative regulation of neuron projection regeneration	13	15	4.58e-02
GO:BP	GO:0032891	negative regulation of organic acid transport	13	15	4.58e-02
GO:BP	GO:0016079	synaptic vesicle exocytosis	47	70	4.60e-02
GO:BP	GO:1900745	positive regulation of p38MAPK cascade	17	21	4.66e-02
GO:BP	GO:2000178	negative regulation of neural precursor cell proliferation	17	21	4.66e-02
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	879	1624	4.67e-02
GO:BP	GO:0015849	organic acid transport	123	204	4.71e-02
GO:BP	GO:0051495	positive regulation of cytoskeleton organization	90	145	4.71e-02
GO:BP	GO:0098727	maintenance of cell number	90	145	4.71e-02
GO:BP	GO:0032869	cellular response to insulin stimulus	99	161	4.71e-02
GO:BP	GO:0032925	regulation of activin receptor signaling pathway	15	18	4.74e-02
GO:BP	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	15	18	4.74e-02
GO:BP	GO:0031069	hair follicle morphogenesis	15	18	4.74e-02
GO:BP	GO:0033032	regulation of myeloid cell apoptotic process	15	18	4.74e-02
GO:BP	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	15	18	4.74e-02
GO:BP	GO:1902903	regulation of supramolecular fiber organization	178	304	4.77e-02
GO:BP	GO:0030501	positive regulation of bone mineralization	24	32	4.78e-02
GO:BP	GO:0042220	response to cocaine	24	32	4.78e-02
GO:BP	GO:0062237	protein localization to postsynapse	24	32	4.78e-02
GO:BP	GO:0070884	regulation of calcineurin-NFAT signaling cascade	24	32	4.78e-02
GO:BP	GO:0106056	regulation of calcineurin-mediated signaling	24	32	4.78e-02
GO:BP	GO:1903539	protein localization to postsynaptic membrane	24	32	4.78e-02
GO:BP	GO:0086004	regulation of cardiac muscle cell contraction	24	32	4.78e-02
GO:BP	GO:0050709	negative regulation of protein secretion	32	45	4.80e-02
GO:BP	GO:0002292	T cell differentiation involved in immune response	32	45	4.80e-02
GO:BP	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	32	45	4.80e-02
GO:BP	GO:0007548	sex differentiation	109	179	4.80e-02
GO:BP	GO:0060997	dendritic spine morphogenesis	32	45	4.80e-02
GO:BP	GO:0046486	glycerolipid metabolic process	167	284	4.81e-02
GO:BP	GO:0051492	regulation of stress fiber assembly	51	77	4.85e-02
GO:BP	GO:0010950	positive regulation of endopeptidase activity	62	96	4.88e-02
GO:BP	GO:0070527	platelet aggregation	35	50	4.88e-02
GO:BP	GO:0051145	smooth muscle cell differentiation	38	55	4.88e-02
GO:BP	GO:1901019	regulation of calcium ion transmembrane transporter activity	35	50	4.88e-02
GO:BP	GO:0031016	pancreas development	35	50	4.88e-02
GO:BP	GO:0030041	actin filament polymerization	78	124	4.90e-02
GO:BP	GO:0046718	symbiont entry into host cell	66	103	4.94e-02
GO:BP	GO:0050954	sensory perception of mechanical stimulus	70	110	4.96e-02

ESRnomtable %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in ESR neargenes") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in ESR neargenes
source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:04510	Focal adhesion	128	169	4.34e-09
KEGG	KEGG:05200	Pathways in cancer	263	391	4.34e-09
KEGG	KEGG:04020	Calcium signaling pathway	123	161	4.34e-09
KEGG	KEGG:04015	Rap1 signaling pathway	121	162	3.73e-08
KEGG	KEGG:04925	Aldosterone synthesis and secretion	64	75	3.73e-08
KEGG	KEGG:04024	cAMP signaling pathway	111	147	5.35e-08
KEGG	KEGG:04360	Axon guidance	114	155	3.91e-07
KEGG	KEGG:04310	Wnt signaling pathway	98	133	3.28e-06
KEGG	KEGG:04911	Insulin secretion	51	62	1.25e-05
KEGG	KEGG:05414	Dilated cardiomyopathy	64	82	1.36e-05
KEGG	KEGG:05205	Proteoglycans in cancer	114	162	1.36e-05
KEGG	KEGG:04970	Salivary secretion	45	54	2.12e-05
KEGG	KEGG:04261	Adrenergic signaling in cardiomyocytes	90	124	2.12e-05
KEGG	KEGG:04022	cGMP-PKG signaling pathway	93	129	2.14e-05
KEGG	KEGG:04520	Adherens junction	64	83	2.19e-05
KEGG	KEGG:04724	Glutamatergic synapse	58	74	2.54e-05
KEGG	KEGG:04927	Cortisol synthesis and secretion	39	46	3.73e-05
KEGG	KEGG:04014	Ras signaling pathway	113	164	4.85e-05
KEGG	KEGG:04512	ECM-receptor interaction	52	66	5.79e-05
KEGG	KEGG:04971	Gastric acid secretion	42	51	6.00e-05
KEGG	KEGG:04010	MAPK signaling pathway	152	231	6.12e-05
KEGG	KEGG:04151	PI3K-Akt signaling pathway	163	250	6.12e-05
KEGG	KEGG:04390	Hippo signaling pathway	91	129	7.77e-05
KEGG	KEGG:04924	Renin secretion	41	50	8.12e-05
KEGG	KEGG:04919	Thyroid hormone signaling pathway	76	105	9.35e-05
KEGG	KEGG:05412	Arrhythmogenic right ventricular cardiomyopathy	52	67	9.52e-05
KEGG	KEGG:04810	Regulation of actin cytoskeleton	114	169	1.36e-04
KEGG	KEGG:05410	Hypertrophic cardiomyopathy	58	77	1.36e-04
KEGG	KEGG:04934	Cushing syndrome	84	119	1.36e-04
KEGG	KEGG:04972	Pancreatic secretion	45	57	1.50e-04
KEGG	KEGG:04725	Cholinergic synapse	61	82	1.50e-04
KEGG	KEGG:04921	Oxytocin signaling pathway	80	113	1.66e-04
KEGG	KEGG:04974	Protein digestion and absorption	44	56	2.20e-04
KEGG	KEGG:04611	Platelet activation	64	88	2.84e-04
KEGG	KEGG:04713	Circadian entrainment	51	68	4.58e-04
KEGG	KEGG:04670	Leukocyte transendothelial migration	56	76	4.58e-04
KEGG	KEGG:04750	Inflammatory mediator regulation of TRP channels	53	72	7.33e-04
KEGG	KEGG:05224	Breast cancer	78	113	7.33e-04
KEGG	KEGG:04514	Cell adhesion molecules	51	69	8.01e-04
KEGG	KEGG:04923	Regulation of lipolysis in adipocytes	33	41	8.50e-04
KEGG	KEGG:04072	Phospholipase D signaling pathway	74	107	9.33e-04
KEGG	KEGG:04928	Parathyroid hormone synthesis, secretion and action	56	78	1.27e-03
KEGG	KEGG:04961	Endocrine and other factor-regulated calcium reabsorption	32	40	1.27e-03
KEGG	KEGG:05032	Morphine addiction	41	54	1.28e-03
KEGG	KEGG:05226	Gastric cancer	77	113	1.33e-03
KEGG	KEGG:04916	Melanogenesis	54	75	1.37e-03
KEGG	KEGG:04148	Efferocytosis	81	120	1.41e-03
KEGG	KEGG:05225	Hepatocellular carcinoma	91	137	1.41e-03
KEGG	KEGG:05218	Melanoma	42	56	1.55e-03
KEGG	KEGG:04728	Dopaminergic synapse	67	97	1.66e-03
KEGG	KEGG:04270	Vascular smooth muscle contraction	64	92	1.66e-03
KEGG	KEGG:04726	Serotonergic synapse	43	58	1.91e-03
KEGG	KEGG:04550	Signaling pathways regulating pluripotency of stem cells	69	101	2.16e-03
KEGG	KEGG:05202	Transcriptional misregulation in cancer	81	122	2.82e-03
KEGG	KEGG:04371	Apelin signaling pathway	70	104	3.70e-03
KEGG	KEGG:04935	Growth hormone synthesis, secretion and action	65	96	4.41e-03
KEGG	KEGG:05165	Human papillomavirus infection	154	252	4.67e-03
KEGG	KEGG:04213	Longevity regulating pathway - multiple species	37	50	4.67e-03
KEGG	KEGG:04929	GnRH secretion	37	50	4.67e-03
KEGG	KEGG:05163	Human cytomegalovirus infection	102	160	4.67e-03
KEGG	KEGG:04926	Relaxin signaling pathway	67	100	5.25e-03
KEGG	KEGG:04915	Estrogen signaling pathway	61	90	5.53e-03
KEGG	KEGG:04727	GABAergic synapse	38	52	5.68e-03
KEGG	KEGG:04976	Bile secretion	31	41	6.23e-03
KEGG	KEGG:04340	Hedgehog signaling pathway	36	49	6.23e-03
KEGG	KEGG:04933	AGE-RAGE signaling pathway in diabetic complications	59	87	6.23e-03
KEGG	KEGG:04530	Tight junction	83	129	8.32e-03
KEGG	KEGG:04540	Gap junction	49	71	8.54e-03
KEGG	KEGG:04742	Taste transduction	17	20	9.03e-03
KEGG	KEGG:05230	Central carbon metabolism in cancer	41	58	9.57e-03
KEGG	KEGG:04380	Osteoclast differentiation	61	92	1.11e-02
KEGG	KEGG:05214	Glioma	45	65	1.12e-02
KEGG	KEGG:04060	Cytokine-cytokine receptor interaction	62	94	1.21e-02
KEGG	KEGG:04152	AMPK signaling pathway	66	101	1.25e-02
KEGG	KEGG:05146	Amoebiasis	43	62	1.27e-02
KEGG	KEGG:04931	Insulin resistance	60	91	1.37e-02
KEGG	KEGG:05210	Colorectal cancer	54	81	1.50e-02
KEGG	KEGG:05206	MicroRNAs in cancer	90	144	1.65e-02
KEGG	KEGG:04720	Long-term potentiation	36	51	1.65e-02
KEGG	KEGG:04922	Glucagon signaling pathway	52	78	1.68e-02
KEGG	KEGG:04350	TGF-beta signaling pathway	59	90	1.68e-02
KEGG	KEGG:04012	ErbB signaling pathway	50	75	1.96e-02
KEGG	KEGG:05222	Small cell lung cancer	54	82	2.04e-02
KEGG	KEGG:01522	Endocrine resistance	54	82	2.04e-02
KEGG	KEGG:05031	Amphetamine addiction	32	45	2.11e-02
KEGG	KEGG:04071	Sphingolipid signaling pathway	66	103	2.16e-02
KEGG	KEGG:01521	EGFR tyrosine kinase inhibitor resistance	48	72	2.19e-02
KEGG	KEGG:04973	Carbohydrate digestion and absorption	22	29	2.30e-02
KEGG	KEGG:04066	HIF-1 signaling pathway	56	86	2.36e-02
KEGG	KEGG:00000	KEGG root term	2855	5451	2.47e-02
KEGG	KEGG:00051	Fructose and mannose metabolism	20	26	2.47e-02
KEGG	KEGG:04913	Ovarian steroidogenesis	20	26	2.47e-02
KEGG	KEGG:04730	Long-term depression	28	39	2.65e-02
KEGG	KEGG:05213	Endometrial cancer	37	54	2.68e-02
KEGG	KEGG:04666	Fc gamma R-mediated phagocytosis	49	75	3.31e-02
KEGG	KEGG:04659	Th17 cell differentiation	40	60	3.92e-02
KEGG	KEGG:05131	Shigellosis	121	204	3.93e-02
KEGG	KEGG:05207	Chemical carcinogenesis - receptor activation	81	132	3.98e-02
KEGG	KEGG:04625	C-type lectin receptor signaling pathway	48	74	4.08e-02
KEGG	KEGG:00514	Other types of O-glycan biosynthesis	25	35	4.08e-02
KEGG	KEGG:04912	GnRH signaling pathway	48	74	4.08e-02
KEGG	KEGG:04930	Type II diabetes mellitus	25	35	4.08e-02
KEGG	KEGG:04061	Viral protein interaction with cytokine and cytokine receptor	15	19	4.25e-02
KEGG	KEGG:04614	Renin-angiotensin system	9	10	4.35e-02
KEGG	KEGG:05033	Nicotine addiction	9	10	4.35e-02
KEGG	KEGG:00564	Glycerophospholipid metabolism	46	71	4.58e-02
KEGG	KEGG:05030	Cocaine addiction	23	32	4.59e-02
KEGG	KEGG:04080	Neuroactive ligand-receptor interaction	63	101	4.76e-02
KEGG	KEGG:05231	Choline metabolism in cancer	51	80	4.91e-02

LR response genes

# LR_resgenes <- gost(query = LR_NG_list$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(LR_resgenes,"data/GO_KEGG_analysis/LR_resgenes.RDS")

LRnom <- gostplot(LR_resgenes, capped = FALSE, interactive = TRUE)
# LRnom

LRnomtable <- LR_resgenes$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

LRnomtable %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in LR neargenes" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in LR neargenes
source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0032501	multicellular organismal process	3517	4504	2.85e-37
GO:BP	GO:0048731	system development	2194	2719	1.88e-35
GO:BP	GO:0007154	cell communication	3123	3983	2.81e-34
GO:BP	GO:0009653	anatomical structure morphogenesis	1527	1844	8.13e-34
GO:BP	GO:0048856	anatomical structure development	3035	3867	8.13e-34
GO:BP	GO:0023052	signaling	3073	3918	8.13e-34
GO:BP	GO:0007275	multicellular organism development	2520	3170	1.90e-33
GO:BP	GO:0032502	developmental process	3261	4179	1.90e-33
GO:BP	GO:0007165	signal transduction	2834	3611	9.26e-31
GO:BP	GO:0050896	response to stimulus	4108	5379	4.91e-29
GO:BP	GO:0051716	cellular response to stimulus	3575	4640	6.17e-29
GO:BP	GO:0007399	nervous system development	1449	1775	5.17e-26
GO:BP	GO:0022008	neurogenesis	1048	1251	8.68e-26
GO:BP	GO:0048869	cellular developmental process	2217	2804	1.25e-25
GO:BP	GO:0030154	cell differentiation	2216	2803	1.35e-25
GO:BP	GO:0048513	animal organ development	1616	2004	1.66e-24
GO:BP	GO:0050793	regulation of developmental process	1384	1697	2.10e-24
GO:BP	GO:0048699	generation of neurons	907	1076	7.45e-24
GO:BP	GO:0007166	cell surface receptor signaling pathway	1460	1801	1.06e-23
GO:BP	GO:0010646	regulation of cell communication	1940	2444	2.20e-23
GO:BP	GO:0030182	neuron differentiation	856	1014	7.74e-23
GO:BP	GO:0023051	regulation of signaling	1933	2438	8.19e-23
GO:BP	GO:0051239	regulation of multicellular organismal process	1547	1924	2.85e-22
GO:BP	GO:0016477	cell migration	848	1011	7.88e-21
GO:BP	GO:0007155	cell adhesion	791	941	7.79e-20
GO:BP	GO:0009887	animal organ morphogenesis	581	673	1.35e-19
GO:BP	GO:0048583	regulation of response to stimulus	2124	2717	1.94e-19
GO:BP	GO:0009966	regulation of signal transduction	1713	2166	9.59e-19
GO:BP	GO:0048468	cell development	1504	1886	1.08e-18
GO:BP	GO:0048870	cell motility	924	1120	2.51e-18
GO:BP	GO:0009888	tissue development	1096	1348	7.00e-18
GO:BP	GO:0000902	cell morphogenesis	607	713	1.85e-17
GO:BP	GO:0007267	cell-cell signaling	892	1082	1.86e-17
GO:BP	GO:0003008	system process	935	1139	2.58e-17
GO:BP	GO:0040012	regulation of locomotion	612	720	2.58e-17
GO:BP	GO:2000145	regulation of cell motility	596	700	3.50e-17
GO:BP	GO:0072359	circulatory system development	723	864	4.90e-17
GO:BP	GO:0035295	tube development	663	787	6.44e-17
GO:BP	GO:0030334	regulation of cell migration	570	668	7.71e-17
GO:BP	GO:0051094	positive regulation of developmental process	760	913	8.43e-17
GO:BP	GO:0031175	neuron projection development	628	743	1.18e-16
GO:BP	GO:0040011	locomotion	676	805	1.28e-16
GO:BP	GO:0048666	neuron development	701	838	1.92e-16
GO:BP	GO:0035239	tube morphogenesis	545	638	2.70e-16
GO:BP	GO:0032989	cellular anatomical entity morphogenesis	505	588	5.26e-16
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	698	837	1.02e-15
GO:BP	GO:0048522	positive regulation of cellular process	3005	3954	1.16e-15
GO:BP	GO:0050789	regulation of biological process	5544	7516	1.29e-15
GO:BP	GO:0030030	cell projection organization	961	1182	1.55e-15
GO:BP	GO:0048518	positive regulation of biological process	3254	4301	2.05e-15
GO:BP	GO:2000026	regulation of multicellular organismal development	784	951	2.95e-15
GO:BP	GO:0048858	cell projection morphogenesis	432	498	3.12e-15
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	935	1150	4.30e-15
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	603	717	4.94e-15
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	428	494	6.88e-15
GO:BP	GO:0048812	neuron projection morphogenesis	416	479	7.60e-15
GO:BP	GO:0001568	blood vessel development	452	525	1.08e-14
GO:BP	GO:0051093	negative regulation of developmental process	528	622	1.14e-14
GO:BP	GO:0045595	regulation of cell differentiation	874	1073	1.96e-14
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	517	609	2.32e-14
GO:BP	GO:0050794	regulation of cellular process	5279	7153	2.55e-14
GO:BP	GO:0001944	vasculature development	472	552	3.18e-14
GO:BP	GO:0065007	biological regulation	5684	7734	8.19e-14
GO:BP	GO:0051240	positive regulation of multicellular organismal process	845	1040	2.20e-13
GO:BP	GO:0141124	intracellular signaling cassette	1051	1314	3.49e-13
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	377	435	4.36e-13
GO:BP	GO:0071495	cellular response to endogenous stimulus	840	1035	4.46e-13
GO:BP	GO:0065008	regulation of biological quality	1480	1893	1.18e-12
GO:BP	GO:0034330	cell junction organization	461	545	3.79e-12
GO:BP	GO:0051128	regulation of cellular component organization	1454	1862	4.53e-12
GO:BP	GO:0048514	blood vessel morphogenesis	386	450	6.46e-12
GO:BP	GO:0045597	positive regulation of cell differentiation	496	591	6.75e-12
GO:BP	GO:0098609	cell-cell adhesion	475	564	6.89e-12
GO:BP	GO:0001503	ossification	268	302	8.52e-12
GO:BP	GO:0009719	response to endogenous stimulus	957	1197	8.53e-12
GO:BP	GO:0048519	negative regulation of biological process	2841	3764	8.92e-12
GO:BP	GO:0048589	developmental growth	425	501	1.43e-11
GO:BP	GO:0048523	negative regulation of cellular process	2682	3550	3.51e-11
GO:BP	GO:0045596	negative regulation of cell differentiation	385	452	6.08e-11
GO:BP	GO:0072001	renal system development	219	244	1.04e-10
GO:BP	GO:0030155	regulation of cell adhesion	428	508	1.07e-10
GO:BP	GO:0035556	intracellular signal transduction	1511	1951	1.59e-10
GO:BP	GO:0007409	axonogenesis	293	337	2.10e-10
GO:BP	GO:0060429	epithelium development	645	792	2.40e-10
GO:BP	GO:0044057	regulation of system process	330	384	2.44e-10
GO:BP	GO:0007417	central nervous system development	570	694	2.75e-10
GO:BP	GO:0002062	chondrocyte differentiation	87	88	3.70e-10
GO:BP	GO:0001822	kidney development	212	237	5.13e-10
GO:BP	GO:0003013	circulatory system process	362	426	5.59e-10
GO:BP	GO:0010975	regulation of neuron projection development	306	355	6.78e-10
GO:BP	GO:0051960	regulation of nervous system development	293	339	9.50e-10
GO:BP	GO:0061564	axon development	319	372	9.59e-10
GO:BP	GO:0006810	transport	2261	2984	9.59e-10
GO:BP	GO:0051049	regulation of transport	873	1098	1.14e-09
GO:BP	GO:0042221	response to chemical	1764	2304	1.45e-09
GO:BP	GO:0051179	localization	2800	3731	1.60e-09
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	422	505	1.66e-09
GO:BP	GO:0098657	import into cell	512	622	1.70e-09
GO:BP	GO:0030900	forebrain development	239	272	1.84e-09
GO:BP	GO:0060322	head development	448	539	1.95e-09
GO:BP	GO:0032879	regulation of localization	1126	1439	1.96e-09
GO:BP	GO:0070848	response to growth factor	454	547	2.15e-09
GO:BP	GO:0016055	Wnt signaling pathway	307	358	2.17e-09
GO:BP	GO:0031344	regulation of cell projection organization	430	516	2.26e-09
GO:BP	GO:0001525	angiogenesis	325	381	2.26e-09
GO:BP	GO:0010647	positive regulation of cell communication	961	1218	2.40e-09
GO:BP	GO:0048729	tissue morphogenesis	381	453	2.59e-09
GO:BP	GO:0023056	positive regulation of signaling	963	1221	2.63e-09
GO:BP	GO:0051241	negative regulation of multicellular organismal process	575	706	3.23e-09
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	207	233	3.62e-09
GO:BP	GO:0007423	sensory organ development	329	387	3.96e-09
GO:BP	GO:0198738	cell-cell signaling by wnt	307	359	4.12e-09
GO:BP	GO:0001501	skeletal system development	297	347	6.89e-09
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	382	456	6.97e-09
GO:BP	GO:0007420	brain development	414	498	9.84e-09
GO:BP	GO:0071363	cellular response to growth factor stimulus	437	528	1.05e-08
GO:BP	GO:0051234	establishment of localization	2438	3240	1.13e-08
GO:BP	GO:0030111	regulation of Wnt signaling pathway	228	261	1.72e-08
GO:BP	GO:0050767	regulation of neurogenesis	251	290	1.77e-08
GO:BP	GO:0061448	connective tissue development	183	205	1.79e-08
GO:BP	GO:0034329	cell junction assembly	277	323	1.82e-08
GO:BP	GO:0070887	cellular response to chemical stimulus	1350	1751	2.34e-08
GO:BP	GO:0001667	ameboidal-type cell migration	293	344	2.79e-08
GO:BP	GO:0008015	blood circulation	303	357	3.22e-08
GO:BP	GO:0040013	negative regulation of locomotion	213	243	3.23e-08
GO:BP	GO:0061061	muscle structure development	441	536	4.28e-08
GO:BP	GO:0071310	cellular response to organic substance	1013	1297	4.30e-08
GO:BP	GO:0048584	positive regulation of response to stimulus	1166	1504	4.67e-08
GO:BP	GO:0016043	cellular component organization	3556	4802	4.67e-08
GO:BP	GO:0009967	positive regulation of signal transduction	861	1093	4.67e-08
GO:BP	GO:0048598	embryonic morphogenesis	353	422	4.79e-08
GO:BP	GO:0006897	endocytosis	407	492	4.79e-08
GO:BP	GO:0007507	heart development	412	499	6.15e-08
GO:BP	GO:0051216	cartilage development	133	145	6.15e-08
GO:BP	GO:0035265	organ growth	118	127	6.64e-08
GO:BP	GO:0030001	metal ion transport	431	524	6.85e-08
GO:BP	GO:0030029	actin filament-based process	519	640	9.17e-08
GO:BP	GO:0006468	protein phosphorylation	757	958	1.97e-07
GO:BP	GO:0030335	positive regulation of cell migration	330	395	2.27e-07
GO:BP	GO:2000147	positive regulation of cell motility	340	408	2.34e-07
GO:BP	GO:0048638	regulation of developmental growth	211	243	2.36e-07
GO:BP	GO:1901888	regulation of cell junction assembly	141	156	2.55e-07
GO:BP	GO:0060070	canonical Wnt signaling pathway	210	242	2.87e-07
GO:BP	GO:2000146	negative regulation of cell motility	190	217	3.19e-07
GO:BP	GO:0030336	negative regulation of cell migration	184	210	4.95e-07
GO:BP	GO:0099177	regulation of trans-synaptic signaling	273	323	5.14e-07
GO:BP	GO:0016310	phosphorylation	894	1145	5.17e-07
GO:BP	GO:0071417	cellular response to organonitrogen compound	365	442	5.21e-07
GO:BP	GO:0040017	positive regulation of locomotion	345	416	5.21e-07
GO:BP	GO:0043547	positive regulation of GTPase activity	105	113	5.34e-07
GO:BP	GO:0009790	embryo development	652	821	5.82e-07
GO:BP	GO:1903522	regulation of blood circulation	171	194	5.88e-07
GO:BP	GO:0050804	modulation of chemical synaptic transmission	272	322	5.89e-07
GO:BP	GO:0045664	regulation of neuron differentiation	119	130	6.08e-07
GO:BP	GO:0009987	cellular process	7680	10686	6.88e-07
GO:BP	GO:0042592	homeostatic process	887	1137	7.63e-07
GO:BP	GO:0016192	vesicle-mediated transport	898	1152	7.94e-07
GO:BP	GO:0060284	regulation of cell development	462	570	7.94e-07
GO:BP	GO:0002009	morphogenesis of an epithelium	308	369	8.32e-07
GO:BP	GO:0072073	kidney epithelium development	103	111	8.68e-07
GO:BP	GO:0044087	regulation of cellular component biogenesis	603	757	8.81e-07
GO:BP	GO:1902531	regulation of intracellular signal transduction	999	1289	9.23e-07
GO:BP	GO:0043087	regulation of GTPase activity	148	166	9.45e-07
GO:BP	GO:0007264	small GTPase-mediated signal transduction	324	390	9.49e-07
GO:BP	GO:0043010	camera-type eye development	199	230	1.11e-06
GO:BP	GO:0031589	cell-substrate adhesion	221	258	1.20e-06
GO:BP	GO:0051130	positive regulation of cellular component organization	672	850	1.22e-06
GO:BP	GO:0010243	response to organonitrogen compound	548	685	1.29e-06
GO:BP	GO:0048585	negative regulation of response to stimulus	927	1193	1.31e-06
GO:BP	GO:0090132	epithelium migration	209	243	1.39e-06
GO:BP	GO:0010631	epithelial cell migration	209	243	1.39e-06
GO:BP	GO:0048705	skeletal system morphogenesis	133	148	1.50e-06
GO:BP	GO:0001649	osteoblast differentiation	154	174	1.52e-06
GO:BP	GO:0090130	tissue migration	212	247	1.57e-06
GO:BP	GO:0014706	striated muscle tissue development	185	213	1.76e-06
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	177	203	1.85e-06
GO:BP	GO:0099537	trans-synaptic signaling	382	467	1.85e-06
GO:BP	GO:0050808	synapse organization	282	337	1.90e-06
GO:BP	GO:0099536	synaptic signaling	394	483	2.08e-06
GO:BP	GO:0040007	growth	556	697	2.08e-06
GO:BP	GO:0023057	negative regulation of signaling	809	1036	2.33e-06
GO:BP	GO:0045165	cell fate commitment	135	151	2.47e-06
GO:BP	GO:0001654	eye development	224	263	2.50e-06
GO:BP	GO:0031214	biomineral tissue development	98	106	2.95e-06
GO:BP	GO:0065009	regulation of molecular function	1003	1299	2.95e-06
GO:BP	GO:0007268	chemical synaptic transmission	378	463	3.20e-06
GO:BP	GO:0098916	anterograde trans-synaptic signaling	378	463	3.20e-06
GO:BP	GO:0048880	sensory system development	226	266	3.30e-06
GO:BP	GO:0021537	telencephalon development	170	195	3.35e-06
GO:BP	GO:0008016	regulation of heart contraction	146	165	3.38e-06
GO:BP	GO:0060560	developmental growth involved in morphogenesis	166	190	3.38e-06
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	240	284	3.39e-06
GO:BP	GO:1901652	response to peptide	305	368	3.54e-06
GO:BP	GO:0030036	actin cytoskeleton organization	456	566	3.61e-06
GO:BP	GO:0030855	epithelial cell differentiation	351	428	3.63e-06
GO:BP	GO:1901700	response to oxygen-containing compound	850	1093	3.66e-06
GO:BP	GO:0009893	positive regulation of metabolic process	1968	2622	3.98e-06
GO:BP	GO:0010648	negative regulation of cell communication	806	1034	4.01e-06
GO:BP	GO:0003007	heart morphogenesis	188	218	4.02e-06
GO:BP	GO:0048871	multicellular organismal-level homeostasis	433	536	4.09e-06
GO:BP	GO:0003206	cardiac chamber morphogenesis	101	110	4.40e-06
GO:BP	GO:0150063	visual system development	224	264	4.48e-06
GO:BP	GO:0010720	positive regulation of cell development	259	309	4.57e-06
GO:BP	GO:0030278	regulation of ossification	75	79	4.77e-06
GO:BP	GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	220	259	4.77e-06
GO:BP	GO:0010632	regulation of epithelial cell migration	164	188	4.82e-06
GO:BP	GO:0090596	sensory organ morphogenesis	152	173	4.96e-06
GO:BP	GO:0010033	response to organic substance	1322	1736	5.17e-06
GO:BP	GO:1901698	response to nitrogen compound	583	736	5.60e-06
GO:BP	GO:0098660	inorganic ion transmembrane transport	421	521	5.60e-06
GO:BP	GO:0009968	negative regulation of signal transduction	759	972	5.63e-06
GO:BP	GO:0044093	positive regulation of molecular function	618	783	6.01e-06
GO:BP	GO:0006811	monoatomic ion transport	570	719	6.22e-06
GO:BP	GO:0050770	regulation of axonogenesis	113	125	6.45e-06
GO:BP	GO:0006812	monoatomic cation transport	491	614	6.45e-06
GO:BP	GO:0003205	cardiac chamber development	134	151	7.05e-06
GO:BP	GO:0048639	positive regulation of developmental growth	108	119	7.29e-06
GO:BP	GO:0071840	cellular component organization or biogenesis	3665	4988	7.88e-06
GO:BP	GO:0048771	tissue remodeling	103	113	8.09e-06
GO:BP	GO:0008150	biological_process	8053	11244	8.24e-06
GO:BP	GO:0098662	inorganic cation transmembrane transport	389	480	8.92e-06
GO:BP	GO:0031401	positive regulation of protein modification process	442	550	9.09e-06
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	376	463	9.22e-06
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	376	463	9.22e-06
GO:BP	GO:0060047	heart contraction	168	194	9.64e-06
GO:BP	GO:1901699	cellular response to nitrogen compound	388	479	1.01e-05
GO:BP	GO:0007186	G protein-coupled receptor signaling pathway	317	386	1.06e-05
GO:BP	GO:0034220	monoatomic ion transmembrane transport	469	587	1.45e-05
GO:BP	GO:0007010	cytoskeleton organization	885	1146	1.58e-05
GO:BP	GO:0048738	cardiac muscle tissue development	173	201	1.58e-05
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	184	215	1.61e-05
GO:BP	GO:0097485	neuron projection guidance	150	172	1.61e-05
GO:BP	GO:0007411	axon guidance	150	172	1.61e-05
GO:BP	GO:0043434	response to peptide hormone	261	314	1.62e-05
GO:BP	GO:0035108	limb morphogenesis	100	110	1.62e-05
GO:BP	GO:0035107	appendage morphogenesis	100	110	1.62e-05
GO:BP	GO:0043062	extracellular structure organization	191	224	1.66e-05
GO:BP	GO:0045229	external encapsulating structure organization	191	224	1.66e-05
GO:BP	GO:0060627	regulation of vesicle-mediated transport	307	374	1.72e-05
GO:BP	GO:0071559	response to transforming growth factor beta	187	219	1.76e-05
GO:BP	GO:0003231	cardiac ventricle development	104	115	1.79e-05
GO:BP	GO:0050673	epithelial cell proliferation	250	300	1.81e-05
GO:BP	GO:0097435	supramolecular fiber organization	503	633	1.84e-05
GO:BP	GO:0060411	cardiac septum morphogenesis	64	67	1.93e-05
GO:BP	GO:0030198	extracellular matrix organization	190	223	1.95e-05
GO:BP	GO:0050877	nervous system process	478	600	2.01e-05
GO:BP	GO:0007389	pattern specification process	239	286	2.02e-05
GO:BP	GO:0003015	heart process	175	204	2.07e-05
GO:BP	GO:0048568	embryonic organ development	252	303	2.23e-05
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	120	135	2.28e-05
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	1810	2415	2.60e-05
GO:BP	GO:0030010	establishment of cell polarity	111	124	2.60e-05
GO:BP	GO:0048588	developmental cell growth	155	179	2.61e-05
GO:BP	GO:0007160	cell-matrix adhesion	147	169	2.79e-05
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	209	248	2.92e-05
GO:BP	GO:0098655	monoatomic cation transmembrane transport	398	495	3.00e-05
GO:BP	GO:0060562	epithelial tube morphogenesis	219	261	3.14e-05
GO:BP	GO:0048592	eye morphogenesis	97	107	3.16e-05
GO:BP	GO:0035023	regulation of Rho protein signal transduction	62	65	3.31e-05
GO:BP	GO:0044089	positive regulation of cellular component biogenesis	318	390	3.48e-05
GO:BP	GO:0022407	regulation of cell-cell adhesion	232	278	3.53e-05
GO:BP	GO:0008283	cell population proliferation	1000	1306	3.75e-05
GO:BP	GO:0042391	regulation of membrane potential	235	282	3.76e-05
GO:BP	GO:0090257	regulation of muscle system process	153	177	3.77e-05
GO:BP	GO:0043408	regulation of MAPK cascade	346	427	3.77e-05
GO:BP	GO:1901701	cellular response to oxygen-containing compound	623	796	3.90e-05
GO:BP	GO:0006793	phosphorus metabolic process	1437	1904	3.96e-05
GO:BP	GO:0048762	mesenchymal cell differentiation	171	200	4.20e-05
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	76	82	5.49e-05
GO:BP	GO:0042330	taxis	205	244	5.62e-05
GO:BP	GO:0006935	chemotaxis	205	244	5.62e-05
GO:BP	GO:0045785	positive regulation of cell adhesion	249	301	5.82e-05
GO:BP	GO:0072006	nephron development	103	115	5.86e-05
GO:BP	GO:0006796	phosphate-containing compound metabolic process	1420	1883	6.23e-05
GO:BP	GO:0060537	muscle tissue development	278	339	6.40e-05
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	1640	2186	6.55e-05
GO:BP	GO:0031399	regulation of protein modification process	707	911	6.56e-05
GO:BP	GO:0003281	ventricular septum development	65	69	6.56e-05
GO:BP	GO:0030326	embryonic limb morphogenesis	80	87	6.61e-05
GO:BP	GO:0035113	embryonic appendage morphogenesis	80	87	6.61e-05
GO:BP	GO:0045667	regulation of osteoblast differentiation	89	98	7.03e-05
GO:BP	GO:0070167	regulation of biomineral tissue development	59	62	7.48e-05
GO:BP	GO:0042127	regulation of cell population proliferation	829	1077	8.19e-05
GO:BP	GO:0034762	regulation of transmembrane transport	246	298	9.01e-05
GO:BP	GO:0001823	mesonephros development	69	74	9.01e-05
GO:BP	GO:0051247	positive regulation of protein metabolic process	706	911	9.37e-05
GO:BP	GO:0031325	positive regulation of cellular metabolic process	1745	2333	9.39e-05
GO:BP	GO:0046903	secretion	491	622	9.45e-05
GO:BP	GO:0060485	mesenchyme development	205	245	9.67e-05
GO:BP	GO:0003279	cardiac septum development	92	102	9.77e-05
GO:BP	GO:0007159	leukocyte cell-cell adhesion	184	218	9.81e-05
GO:BP	GO:0032835	glomerulus development	52	54	1.02e-04
GO:BP	GO:0042327	positive regulation of phosphorylation	335	415	1.03e-04
GO:BP	GO:0051174	regulation of phosphorus metabolic process	627	805	1.08e-04
GO:BP	GO:0055123	digestive system development	87	96	1.11e-04
GO:BP	GO:0072163	mesonephric epithelium development	68	73	1.14e-04
GO:BP	GO:0072164	mesonephric tubule development	68	73	1.14e-04
GO:BP	GO:0000165	MAPK cascade	402	504	1.14e-04
GO:BP	GO:0019220	regulation of phosphate metabolic process	626	804	1.18e-04
GO:BP	GO:0051962	positive regulation of nervous system development	179	212	1.25e-04
GO:BP	GO:0051129	negative regulation of cellular component organization	440	555	1.32e-04
GO:BP	GO:0003012	muscle system process	266	325	1.35e-04
GO:BP	GO:0150115	cell-substrate junction organization	86	95	1.39e-04
GO:BP	GO:0030282	bone mineralization	72	78	1.44e-04
GO:BP	GO:0140352	export from cell	469	594	1.45e-04
GO:BP	GO:0001657	ureteric bud development	67	72	1.46e-04
GO:BP	GO:0007610	behavior	338	420	1.53e-04
GO:BP	GO:0007163	establishment or maintenance of cell polarity	156	183	1.62e-04
GO:BP	GO:0014855	striated muscle cell proliferation	56	59	1.66e-04
GO:BP	GO:0001763	morphogenesis of a branching structure	126	145	1.68e-04
GO:BP	GO:0010463	mesenchymal cell proliferation	36	36	1.79e-04
GO:BP	GO:0051336	regulation of hydrolase activity	346	431	1.79e-04
GO:BP	GO:0050807	regulation of synapse organization	148	173	1.83e-04
GO:BP	GO:0030100	regulation of endocytosis	166	196	1.84e-04
GO:BP	GO:0007517	muscle organ development	221	267	1.84e-04
GO:BP	GO:0003002	regionalization	214	258	1.92e-04
GO:BP	GO:0048565	digestive tract development	80	88	1.94e-04
GO:BP	GO:0007259	receptor signaling pathway via JAK-STAT	80	88	1.94e-04
GO:BP	GO:0007044	cell-substrate junction assembly	80	88	1.94e-04
GO:BP	GO:0048167	regulation of synaptic plasticity	121	139	2.06e-04
GO:BP	GO:0051961	negative regulation of nervous system development	97	109	2.06e-04
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	97	109	2.06e-04
GO:BP	GO:0009605	response to external stimulus	1179	1559	2.07e-04
GO:BP	GO:1990138	neuron projection extension	117	134	2.10e-04
GO:BP	GO:0001764	neuron migration	113	129	2.13e-04
GO:BP	GO:0043085	positive regulation of catalytic activity	432	546	2.23e-04
GO:BP	GO:0001934	positive regulation of protein phosphorylation	319	396	2.28e-04
GO:BP	GO:0055017	cardiac muscle tissue growth	60	64	2.33e-04
GO:BP	GO:0046622	positive regulation of organ growth	35	35	2.39e-04
GO:BP	GO:0050803	regulation of synapse structure or activity	150	176	2.39e-04
GO:BP	GO:0048593	camera-type eye morphogenesis	79	87	2.41e-04
GO:BP	GO:0050768	negative regulation of neurogenesis	92	103	2.42e-04
GO:BP	GO:0007162	negative regulation of cell adhesion	157	185	2.46e-04
GO:BP	GO:0051641	cellular localization	1950	2623	2.46e-04
GO:BP	GO:0043269	regulation of monoatomic ion transport	232	282	2.48e-04
GO:BP	GO:0050920	regulation of chemotaxis	116	133	2.51e-04
GO:BP	GO:0031346	positive regulation of cell projection organization	235	286	2.58e-04
GO:BP	GO:0033002	muscle cell proliferation	131	152	2.62e-04
GO:BP	GO:1901653	cellular response to peptide	225	273	2.62e-04
GO:BP	GO:0045666	positive regulation of neuron differentiation	54	57	2.73e-04
GO:BP	GO:0055085	transmembrane transport	710	921	2.77e-04
GO:BP	GO:0042063	gliogenesis	201	242	2.88e-04
GO:BP	GO:0050769	positive regulation of neurogenesis	156	184	2.88e-04
GO:BP	GO:0061035	regulation of cartilage development	48	50	2.96e-04
GO:BP	GO:0007229	integrin-mediated signaling pathway	78	86	2.97e-04
GO:BP	GO:0009725	response to hormone	479	610	3.10e-04
GO:BP	GO:0016331	morphogenesis of embryonic epithelium	107	122	3.12e-04
GO:BP	GO:0032330	regulation of chondrocyte differentiation	34	34	3.19e-04
GO:BP	GO:0097696	receptor signaling pathway via STAT	82	91	3.25e-04
GO:BP	GO:0016358	dendrite development	155	183	3.40e-04
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	176	210	3.40e-04
GO:BP	GO:0050678	regulation of epithelial cell proliferation	206	249	3.70e-04
GO:BP	GO:0060993	kidney morphogenesis	63	68	3.81e-04
GO:BP	GO:0032970	regulation of actin filament-based process	245	300	3.88e-04
GO:BP	GO:0010721	negative regulation of cell development	154	182	4.03e-04
GO:BP	GO:0001952	regulation of cell-matrix adhesion	81	90	4.08e-04
GO:BP	GO:0061138	morphogenesis of a branching epithelium	117	135	4.31e-04
GO:BP	GO:0032940	secretion by cell	434	551	4.55e-04
GO:BP	GO:0051057	positive regulation of small GTPase mediated signal transduction	52	55	4.65e-04
GO:BP	GO:0007015	actin filament organization	288	357	4.70e-04
GO:BP	GO:0072009	nephron epithelium development	76	84	4.70e-04
GO:BP	GO:0001656	metanephros development	57	61	4.93e-04
GO:BP	GO:0042325	regulation of phosphorylation	532	683	5.17e-04
GO:BP	GO:0030500	regulation of bone mineralization	46	48	5.17e-04
GO:BP	GO:0003018	vascular process in circulatory system	163	194	5.18e-04
GO:BP	GO:0007179	transforming growth factor beta receptor signaling pathway	145	171	5.55e-04
GO:BP	GO:1901342	regulation of vasculature development	166	198	5.59e-04
GO:BP	GO:0021953	central nervous system neuron differentiation	88	99	5.59e-04
GO:BP	GO:0007266	Rho protein signal transduction	96	109	5.76e-04
GO:BP	GO:0001775	cell activation	490	627	5.92e-04
GO:BP	GO:0045216	cell-cell junction organization	130	152	6.10e-04
GO:BP	GO:0031032	actomyosin structure organization	155	184	6.10e-04
GO:BP	GO:1902893	regulation of miRNA transcription	56	60	6.33e-04
GO:BP	GO:0018105	peptidyl-serine phosphorylation	137	161	6.34e-04
GO:BP	GO:0002521	leukocyte differentiation	298	371	6.34e-04
GO:BP	GO:1903037	regulation of leukocyte cell-cell adhesion	165	197	6.49e-04
GO:BP	GO:0060412	ventricular septum morphogenesis	39	40	6.49e-04
GO:BP	GO:0051050	positive regulation of transport	448	571	6.53e-04
GO:BP	GO:0048041	focal adhesion assembly	70	77	6.59e-04
GO:BP	GO:0021987	cerebral cortex development	83	93	6.59e-04
GO:BP	GO:0006816	calcium ion transport	215	262	6.66e-04
GO:BP	GO:0051345	positive regulation of hydrolase activity	218	266	6.91e-04
GO:BP	GO:0043542	endothelial cell migration	147	174	7.07e-04
GO:BP	GO:0043583	ear development	129	151	7.16e-04
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	554	714	7.24e-04
GO:BP	GO:0060419	heart growth	65	71	7.27e-04
GO:BP	GO:0018209	peptidyl-serine modification	143	169	7.61e-04
GO:BP	GO:0060043	regulation of cardiac muscle cell proliferation	31	31	8.05e-04
GO:BP	GO:0018212	peptidyl-tyrosine modification	139	164	8.23e-04
GO:BP	GO:0006898	receptor-mediated endocytosis	153	182	8.31e-04
GO:BP	GO:0010959	regulation of metal ion transport	197	239	8.31e-04
GO:BP	GO:0098771	inorganic ion homeostasis	280	348	8.43e-04
GO:BP	GO:0010594	regulation of endothelial cell migration	117	136	8.45e-04
GO:BP	GO:0032870	cellular response to hormone stimulus	344	433	8.75e-04
GO:BP	GO:0046620	regulation of organ growth	64	70	9.22e-04
GO:BP	GO:0043068	positive regulation of programmed cell death	310	388	9.34e-04
GO:BP	GO:0050772	positive regulation of axonogenesis	59	64	1.00e-03
GO:BP	GO:0048645	animal organ formation	49	52	1.00e-03
GO:BP	GO:0021543	pallium development	116	135	1.02e-03
GO:BP	GO:0045765	regulation of angiogenesis	162	194	1.03e-03
GO:BP	GO:0090066	regulation of anatomical structure size	303	379	1.03e-03
GO:BP	GO:0043410	positive regulation of MAPK cascade	234	288	1.08e-03
GO:BP	GO:0098900	regulation of action potential	37	38	1.15e-03
GO:BP	GO:0010810	regulation of cell-substrate adhesion	137	162	1.15e-03
GO:BP	GO:0018108	peptidyl-tyrosine phosphorylation	137	162	1.15e-03
GO:BP	GO:0061005	cell differentiation involved in kidney development	37	38	1.15e-03
GO:BP	GO:0010717	regulation of epithelial to mesenchymal transition	76	85	1.20e-03
GO:BP	GO:0022604	regulation of cell morphogenesis	161	193	1.20e-03
GO:BP	GO:0032409	regulation of transporter activity	126	148	1.20e-03
GO:BP	GO:0030177	positive regulation of Wnt signaling pathway	96	110	1.23e-03
GO:BP	GO:0043588	skin development	147	175	1.24e-03
GO:BP	GO:0001932	regulation of protein phosphorylation	499	642	1.27e-03
GO:BP	GO:0070588	calcium ion transmembrane transport	174	210	1.29e-03
GO:BP	GO:0010633	negative regulation of epithelial cell migration	48	51	1.29e-03
GO:BP	GO:0061326	renal tubule development	67	74	1.29e-03
GO:BP	GO:0021954	central nervous system neuron development	53	57	1.31e-03
GO:BP	GO:0035148	tube formation	107	124	1.33e-03
GO:BP	GO:0061351	neural precursor cell proliferation	103	119	1.39e-03
GO:BP	GO:0071375	cellular response to peptide hormone stimulus	190	231	1.39e-03
GO:BP	GO:0042692	muscle cell differentiation	260	323	1.43e-03
GO:BP	GO:0051246	regulation of protein metabolic process	1197	1595	1.44e-03
GO:BP	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	29	29	1.47e-03
GO:BP	GO:0044409	symbiont entry into host	95	109	1.48e-03
GO:BP	GO:0055021	regulation of cardiac muscle tissue growth	42	44	1.49e-03
GO:BP	GO:0008284	positive regulation of cell population proliferation	471	605	1.52e-03
GO:BP	GO:0006814	sodium ion transport	117	137	1.61e-03
GO:BP	GO:0071772	response to BMP	102	118	1.67e-03
GO:BP	GO:0060348	bone development	124	146	1.67e-03
GO:BP	GO:0048008	platelet-derived growth factor receptor signaling pathway	47	50	1.67e-03
GO:BP	GO:0071773	cellular response to BMP stimulus	102	118	1.67e-03
GO:BP	GO:0050900	leukocyte migration	162	195	1.70e-03
GO:BP	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	98	113	1.73e-03
GO:BP	GO:1901343	negative regulation of vasculature development	61	67	1.82e-03
GO:BP	GO:2000181	negative regulation of blood vessel morphogenesis	61	67	1.82e-03
GO:BP	GO:0003151	outflow tract morphogenesis	61	67	1.82e-03
GO:BP	GO:0022612	gland morphogenesis	82	93	1.87e-03
GO:BP	GO:0007416	synapse assembly	116	136	1.91e-03
GO:BP	GO:0045665	negative regulation of neuron differentiation	41	43	1.95e-03
GO:BP	GO:0060038	cardiac muscle cell proliferation	41	43	1.95e-03
GO:BP	GO:0008285	negative regulation of cell population proliferation	369	469	1.98e-03
GO:BP	GO:0060421	positive regulation of heart growth	28	28	1.99e-03
GO:BP	GO:0072175	epithelial tube formation	101	117	1.99e-03
GO:BP	GO:2000628	regulation of miRNA metabolic process	65	72	1.99e-03
GO:BP	GO:0061614	miRNA transcription	56	61	1.99e-03
GO:BP	GO:0060420	regulation of heart growth	46	49	2.11e-03
GO:BP	GO:0090109	regulation of cell-substrate junction assembly	51	55	2.11e-03
GO:BP	GO:1903053	regulation of extracellular matrix organization	46	49	2.11e-03
GO:BP	GO:0051893	regulation of focal adhesion assembly	51	55	2.11e-03
GO:BP	GO:0030048	actin filament-based movement	93	107	2.14e-03
GO:BP	GO:0030097	hemopoiesis	484	624	2.20e-03
GO:BP	GO:1903131	mononuclear cell differentiation	225	278	2.21e-03
GO:BP	GO:0110020	regulation of actomyosin structure organization	77	87	2.24e-03
GO:BP	GO:0010586	miRNA metabolic process	77	87	2.24e-03
GO:BP	GO:0043065	positive regulation of apoptotic process	302	380	2.24e-03
GO:BP	GO:0016525	negative regulation of angiogenesis	60	66	2.25e-03
GO:BP	GO:0060541	respiratory system development	136	162	2.30e-03
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	173	210	2.34e-03
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	156	188	2.47e-03
GO:BP	GO:0022898	regulation of transmembrane transporter activity	118	139	2.47e-03
GO:BP	GO:0050790	regulation of catalytic activity	682	893	2.49e-03
GO:BP	GO:0150116	regulation of cell-substrate junction organization	55	60	2.49e-03
GO:BP	GO:0002064	epithelial cell development	125	148	2.49e-03
GO:BP	GO:0071407	cellular response to organic cyclic compound	301	379	2.49e-03
GO:BP	GO:0008360	regulation of cell shape	92	106	2.55e-03
GO:BP	GO:0051963	regulation of synapse assembly	68	76	2.59e-03
GO:BP	GO:1901890	positive regulation of cell junction assembly	68	76	2.59e-03
GO:BP	GO:0045663	positive regulation of myoblast differentiation	34	35	2.59e-03
GO:BP	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	114	134	2.62e-03
GO:BP	GO:0098901	regulation of cardiac muscle cell action potential	27	27	2.64e-03
GO:BP	GO:0010464	regulation of mesenchymal cell proliferation	27	27	2.64e-03
GO:BP	GO:0006942	regulation of striated muscle contraction	72	81	2.66e-03
GO:BP	GO:0010976	positive regulation of neuron projection development	110	129	2.79e-03
GO:BP	GO:0055117	regulation of cardiac muscle contraction	59	65	2.79e-03
GO:BP	GO:0008361	regulation of cell size	124	147	2.92e-03
GO:BP	GO:0030509	BMP signaling pathway	95	110	2.94e-03
GO:BP	GO:0072080	nephron tubule development	63	70	3.04e-03
GO:BP	GO:0046849	bone remodeling	54	59	3.14e-03
GO:BP	GO:0071695	anatomical structure maturation	127	151	3.16e-03
GO:BP	GO:0032101	regulation of response to external stimulus	505	654	3.25e-03
GO:BP	GO:0060840	artery development	75	85	3.32e-03
GO:BP	GO:0061337	cardiac conduction	75	85	3.32e-03
GO:BP	GO:0033135	regulation of peptidyl-serine phosphorylation	75	85	3.32e-03
GO:BP	GO:1903039	positive regulation of leukocyte cell-cell adhesion	123	146	3.43e-03
GO:BP	GO:0061572	actin filament bundle organization	112	132	3.69e-03
GO:BP	GO:0036211	protein modification process	1696	2291	3.69e-03
GO:BP	GO:0014013	regulation of gliogenesis	62	69	3.80e-03
GO:BP	GO:0043270	positive regulation of monoatomic ion transport	108	127	3.95e-03
GO:BP	GO:0061333	renal tubule morphogenesis	53	58	3.95e-03
GO:BP	GO:0072028	nephron morphogenesis	53	58	3.95e-03
GO:BP	GO:0048864	stem cell development	66	74	3.95e-03
GO:BP	GO:0010634	positive regulation of epithelial cell migration	108	127	3.95e-03
GO:BP	GO:0014897	striated muscle hypertrophy	66	74	3.95e-03
GO:BP	GO:0098727	maintenance of cell number	122	145	4.00e-03
GO:BP	GO:0031345	negative regulation of cell projection organization	122	145	4.00e-03
GO:BP	GO:0031623	receptor internalization	78	89	4.00e-03
GO:BP	GO:0060173	limb development	115	136	4.00e-03
GO:BP	GO:0048736	appendage development	115	136	4.00e-03
GO:BP	GO:0042476	odontogenesis	70	79	4.00e-03
GO:BP	GO:0048878	chemical homeostasis	516	670	4.18e-03
GO:BP	GO:0000003	reproduction	672	882	4.19e-03
GO:BP	GO:0045669	positive regulation of osteoblast differentiation	48	52	4.27e-03
GO:BP	GO:0051017	actin filament bundle assembly	111	131	4.30e-03
GO:BP	GO:0046718	symbiont entry into host cell	89	103	4.40e-03
GO:BP	GO:0060350	endochondral bone morphogenesis	43	46	4.41e-03
GO:BP	GO:0006937	regulation of muscle contraction	107	126	4.64e-03
GO:BP	GO:0030324	lung development	121	144	4.68e-03
GO:BP	GO:0031099	regeneration	121	144	4.68e-03
GO:BP	GO:0003300	cardiac muscle hypertrophy	65	73	4.84e-03
GO:BP	GO:0060349	bone morphogenesis	65	73	4.84e-03
GO:BP	GO:0055023	positive regulation of cardiac muscle tissue growth	25	25	4.84e-03
GO:BP	GO:0055006	cardiac cell development	69	78	4.91e-03
GO:BP	GO:0050890	cognition	174	213	4.91e-03
GO:BP	GO:0030323	respiratory tube development	124	148	5.02e-03
GO:BP	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	127	152	5.40e-03
GO:BP	GO:0042733	embryonic digit morphogenesis	47	51	5.44e-03
GO:BP	GO:0003208	cardiac ventricle morphogenesis	56	62	5.44e-03
GO:BP	GO:0045778	positive regulation of ossification	37	39	5.46e-03
GO:BP	GO:0019827	stem cell population maintenance	120	143	5.48e-03
GO:BP	GO:0040008	regulation of growth	361	462	5.58e-03
GO:BP	GO:0042981	regulation of apoptotic process	780	1031	5.58e-03
GO:BP	GO:0023061	signal release	251	315	5.62e-03
GO:BP	GO:0010628	positive regulation of gene expression	571	746	5.64e-03
GO:BP	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	80	92	5.70e-03
GO:BP	GO:0071805	potassium ion transmembrane transport	102	120	5.86e-03
GO:BP	GO:0086004	regulation of cardiac muscle cell contraction	31	32	5.94e-03
GO:BP	GO:0001838	embryonic epithelial tube formation	91	106	5.94e-03
GO:BP	GO:0035850	epithelial cell differentiation involved in kidney development	31	32	5.94e-03
GO:BP	GO:0007043	cell-cell junction assembly	91	106	5.94e-03
GO:BP	GO:0014033	neural crest cell differentiation	68	77	5.96e-03
GO:BP	GO:0072088	nephron epithelium morphogenesis	51	56	6.14e-03
GO:BP	GO:0048708	astrocyte differentiation	51	56	6.14e-03
GO:BP	GO:0010817	regulation of hormone levels	253	318	6.26e-03
GO:BP	GO:0003006	developmental process involved in reproduction	443	573	6.28e-03
GO:BP	GO:0001894	tissue homeostasis	136	164	6.30e-03
GO:BP	GO:0060249	anatomical structure homeostasis	136	164	6.30e-03
GO:BP	GO:0046777	protein autophosphorylation	119	142	6.32e-03
GO:BP	GO:0048839	inner ear development	112	133	6.38e-03
GO:BP	GO:0071875	adrenergic receptor signaling pathway	24	24	6.47e-03
GO:BP	GO:0098868	bone growth	24	24	6.47e-03
GO:BP	GO:0010001	glial cell differentiation	149	181	6.53e-03
GO:BP	GO:0048469	cell maturation	94	110	6.60e-03
GO:BP	GO:0031016	pancreas development	46	50	6.74e-03
GO:BP	GO:2000630	positive regulation of miRNA metabolic process	46	50	6.74e-03
GO:BP	GO:0030038	contractile actin filament bundle assembly	79	91	6.76e-03
GO:BP	GO:0043149	stress fiber assembly	79	91	6.76e-03
GO:BP	GO:0007272	ensheathment of neurons	101	119	6.78e-03
GO:BP	GO:0008366	axon ensheathment	101	119	6.78e-03
GO:BP	GO:0001837	epithelial to mesenchymal transition	115	137	6.81e-03
GO:BP	GO:0010596	negative regulation of endothelial cell migration	36	38	6.91e-03
GO:BP	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	75	86	6.95e-03
GO:BP	GO:0060041	retina development in camera-type eye	90	105	6.95e-03
GO:BP	GO:1902895	positive regulation of miRNA transcription	41	44	7.04e-03
GO:BP	GO:0034103	regulation of tissue remodeling	41	44	7.04e-03
GO:BP	GO:0022414	reproductive process	664	874	7.20e-03
GO:BP	GO:0043067	regulation of programmed cell death	800	1060	7.23e-03
GO:BP	GO:0060341	regulation of cellular localization	592	776	7.41e-03
GO:BP	GO:0003179	heart valve morphogenesis	50	55	7.57e-03
GO:BP	GO:0048732	gland development	245	308	7.60e-03
GO:BP	GO:0021955	central nervous system neuron axonogenesis	30	31	7.69e-03
GO:BP	GO:0035725	sodium ion transmembrane transport	82	95	7.72e-03
GO:BP	GO:0010977	negative regulation of neuron projection development	93	109	7.74e-03
GO:BP	GO:0061458	reproductive system development	167	205	7.87e-03
GO:BP	GO:0008544	epidermis development	170	209	8.09e-03
GO:BP	GO:0021675	nerve development	54	60	8.17e-03
GO:BP	GO:1990778	protein localization to cell periphery	229	287	8.29e-03
GO:BP	GO:0032231	regulation of actin filament bundle assembly	74	85	8.37e-03
GO:BP	GO:0007369	gastrulation	117	140	8.48e-03
GO:BP	GO:0003170	heart valve development	58	65	8.52e-03
GO:BP	GO:0060291	long-term synaptic potentiation	58	65	8.52e-03
GO:BP	GO:0048754	branching morphogenesis of an epithelial tube	96	113	8.54e-03
GO:BP	GO:0051924	regulation of calcium ion transport	127	153	8.56e-03
GO:BP	GO:0061036	positive regulation of cartilage development	23	23	8.56e-03
GO:BP	GO:0003416	endochondral bone growth	23	23	8.56e-03
GO:BP	GO:0002685	regulation of leukocyte migration	103	122	8.56e-03
GO:BP	GO:0002063	chondrocyte development	23	23	8.56e-03
GO:BP	GO:0060037	pharyngeal system development	23	23	8.56e-03
GO:BP	GO:0097553	calcium ion transmembrane import into cytosol	103	122	8.56e-03
GO:BP	GO:0014896	muscle hypertrophy	66	75	8.57e-03
GO:BP	GO:0090288	negative regulation of cellular response to growth factor stimulus	66	75	8.57e-03
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	1366	1841	8.68e-03
GO:BP	GO:1903115	regulation of actin filament-based movement	35	37	8.77e-03
GO:BP	GO:0002090	regulation of receptor internalization	40	43	8.85e-03
GO:BP	GO:0045321	leukocyte activation	410	530	8.87e-03
GO:BP	GO:0006813	potassium ion transport	113	135	9.08e-03
GO:BP	GO:0050870	positive regulation of T cell activation	113	135	9.08e-03
GO:BP	GO:0051051	negative regulation of transport	228	286	9.08e-03
GO:BP	GO:0042552	myelination	99	117	9.19e-03
GO:BP	GO:0014910	regulation of smooth muscle cell migration	49	54	9.22e-03
GO:BP	GO:0072078	nephron tubule morphogenesis	49	54	9.22e-03
GO:BP	GO:0042475	odontogenesis of dentin-containing tooth	49	54	9.22e-03
GO:BP	GO:0055074	calcium ion homeostasis	175	216	9.37e-03
GO:BP	GO:0030098	lymphocyte differentiation	200	249	9.41e-03
GO:BP	GO:0001659	temperature homeostasis	109	130	9.82e-03
GO:BP	GO:0009612	response to mechanical stimulus	126	152	9.82e-03
GO:BP	GO:0035270	endocrine system development	73	84	9.82e-03
GO:BP	GO:0034764	positive regulation of transmembrane transport	109	130	9.82e-03
GO:BP	GO:0048562	embryonic organ morphogenesis	149	182	9.82e-03
GO:BP	GO:0048546	digestive tract morphogenesis	29	30	9.82e-03
GO:BP	GO:0046850	regulation of bone remodeling	29	30	9.82e-03
GO:BP	GO:0021700	developmental maturation	165	203	9.84e-03
GO:BP	GO:1990845	adaptive thermogenesis	102	121	9.84e-03
GO:BP	GO:0009952	anterior/posterior pattern specification	102	121	9.84e-03
GO:BP	GO:0050867	positive regulation of cell activation	165	203	9.84e-03
GO:BP	GO:0007346	regulation of mitotic cell cycle	328	420	9.87e-03
GO:BP	GO:0009891	positive regulation of biosynthetic process	1376	1856	9.87e-03
GO:BP	GO:0048259	regulation of receptor-mediated endocytosis	69	79	1.00e-02
GO:BP	GO:0050680	negative regulation of epithelial cell proliferation	84	98	1.00e-02
GO:BP	GO:0030031	cell projection assembly	348	447	1.01e-02
GO:BP	GO:0042110	T cell activation	242	305	1.01e-02
GO:BP	GO:0048644	muscle organ morphogenesis	57	64	1.01e-02
GO:BP	GO:0010718	positive regulation of epithelial to mesenchymal transition	44	48	1.02e-02
GO:BP	GO:0014032	neural crest cell development	61	69	1.02e-02
GO:BP	GO:0001755	neural crest cell migration	44	48	1.02e-02
GO:BP	GO:0071396	cellular response to lipid	304	388	1.04e-02
GO:BP	GO:0060048	cardiac muscle contraction	98	116	1.05e-02
GO:BP	GO:0099173	postsynapse organization	122	147	1.05e-02
GO:BP	GO:0045598	regulation of fat cell differentiation	80	93	1.05e-02
GO:BP	GO:0033043	regulation of organelle organization	720	953	1.07e-02
GO:BP	GO:0032880	regulation of protein localization	528	691	1.08e-02
GO:BP	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	115	138	1.09e-02
GO:BP	GO:0031641	regulation of myelination	34	36	1.10e-02
GO:BP	GO:0003203	endocardial cushion morphogenesis	34	36	1.10e-02
GO:BP	GO:0048608	reproductive structure development	164	202	1.10e-02
GO:BP	GO:0033036	macromolecule localization	1702	2309	1.10e-02
GO:BP	GO:0006874	intracellular calcium ion homeostasis	164	202	1.10e-02
GO:BP	GO:0003177	pulmonary valve development	22	22	1.11e-02
GO:BP	GO:0060045	positive regulation of cardiac muscle cell proliferation	22	22	1.11e-02
GO:BP	GO:0050921	positive regulation of chemotaxis	72	83	1.15e-02
GO:BP	GO:0050679	positive regulation of epithelial cell proliferation	118	142	1.15e-02
GO:BP	GO:0007611	learning or memory	154	189	1.16e-02
GO:BP	GO:0051235	maintenance of location	201	251	1.16e-02
GO:BP	GO:0006936	muscle contraction	204	255	1.17e-02
GO:BP	GO:0002028	regulation of sodium ion transport	52	58	1.18e-02
GO:BP	GO:0033138	positive regulation of peptidyl-serine phosphorylation	52	58	1.18e-02
GO:BP	GO:0021915	neural tube development	111	133	1.18e-02
GO:BP	GO:0045661	regulation of myoblast differentiation	52	58	1.18e-02
GO:BP	GO:0050865	regulation of cell activation	273	347	1.19e-02
GO:BP	GO:0002696	positive regulation of leukocyte activation	160	197	1.21e-02
GO:BP	GO:0120031	plasma membrane bounded cell projection assembly	340	437	1.21e-02
GO:BP	GO:0007492	endoderm development	56	63	1.21e-02
GO:BP	GO:0086001	cardiac muscle cell action potential	56	63	1.21e-02
GO:BP	GO:0032535	regulation of cellular component size	228	287	1.21e-02
GO:BP	GO:0010232	vascular transport	60	68	1.21e-02
GO:BP	GO:0019915	lipid storage	60	68	1.21e-02
GO:BP	GO:0043502	regulation of muscle adaptation	60	68	1.21e-02
GO:BP	GO:0150104	transport across blood-brain barrier	60	68	1.21e-02
GO:BP	GO:0071675	regulation of mononuclear cell migration	60	68	1.21e-02
GO:BP	GO:0150117	positive regulation of cell-substrate junction organization	28	29	1.24e-02
GO:BP	GO:0060563	neuroepithelial cell differentiation	28	29	1.24e-02
GO:BP	GO:1990776	response to angiotensin	28	29	1.24e-02
GO:BP	GO:0002067	glandular epithelial cell differentiation	43	47	1.24e-02
GO:BP	GO:0014743	regulation of muscle hypertrophy	43	47	1.24e-02
GO:BP	GO:0014015	positive regulation of gliogenesis	43	47	1.24e-02
GO:BP	GO:0045860	positive regulation of protein kinase activity	150	184	1.26e-02
GO:BP	GO:0070252	actin-mediated cell contraction	75	87	1.29e-02
GO:BP	GO:0008104	protein localization	1478	2000	1.34e-02
GO:BP	GO:0018193	peptidyl-amino acid modification	427	555	1.34e-02
GO:BP	GO:1905314	semi-lunar valve development	38	41	1.35e-02
GO:BP	GO:0022409	positive regulation of cell-cell adhesion	143	175	1.35e-02
GO:BP	GO:1905330	regulation of morphogenesis of an epithelium	38	41	1.35e-02
GO:BP	GO:0010171	body morphogenesis	38	41	1.35e-02
GO:BP	GO:0001936	regulation of endothelial cell proliferation	82	96	1.37e-02
GO:BP	GO:0070727	cellular macromolecule localization	1485	2010	1.38e-02
GO:BP	GO:0045444	fat cell differentiation	146	179	1.39e-02
GO:BP	GO:0001935	endothelial cell proliferation	96	114	1.40e-02
GO:BP	GO:0051090	regulation of DNA-binding transcription factor activity	193	241	1.40e-02
GO:BP	GO:0051492	regulation of stress fiber assembly	67	77	1.40e-02
GO:BP	GO:0050863	regulation of T cell activation	165	204	1.40e-02
GO:BP	GO:0051046	regulation of secretion	309	396	1.43e-02
GO:BP	GO:1904892	regulation of receptor signaling pathway via STAT	51	57	1.43e-02
GO:BP	GO:0055013	cardiac muscle cell development	63	72	1.43e-02
GO:BP	GO:0014812	muscle cell migration	63	72	1.43e-02
GO:BP	GO:0008589	regulation of smoothened signaling pathway	63	72	1.43e-02
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	208	261	1.44e-02
GO:BP	GO:0060384	innervation	21	21	1.45e-02
GO:BP	GO:0042634	regulation of hair cycle	21	21	1.45e-02
GO:BP	GO:0007224	smoothened signaling pathway	99	118	1.50e-02
GO:BP	GO:0035019	somatic stem cell population maintenance	42	46	1.55e-02
GO:BP	GO:0072171	mesonephric tubule morphogenesis	42	46	1.55e-02
GO:BP	GO:0003197	endocardial cushion development	42	46	1.55e-02
GO:BP	GO:0010611	regulation of cardiac muscle hypertrophy	42	46	1.55e-02
GO:BP	GO:0032868	response to insulin	164	203	1.58e-02
GO:BP	GO:0016266	O-glycan processing	27	28	1.60e-02
GO:BP	GO:0048675	axon extension	81	95	1.60e-02
GO:BP	GO:0098739	import across plasma membrane	102	122	1.60e-02
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	1326	1791	1.60e-02
GO:BP	GO:0038127	ERBB signaling pathway	88	104	1.64e-02
GO:BP	GO:0072132	mesenchyme morphogenesis	46	51	1.68e-02
GO:BP	GO:0099003	vesicle-mediated transport in synapse	138	169	1.70e-02
GO:BP	GO:0048286	lung alveolus development	37	40	1.71e-02
GO:BP	GO:0002376	immune system process	1050	1410	1.72e-02
GO:BP	GO:0006954	inflammatory response	330	425	1.72e-02
GO:BP	GO:0006915	apoptotic process	1026	1377	1.74e-02
GO:BP	GO:0003229	ventricular cardiac muscle tissue development	50	56	1.75e-02
GO:BP	GO:0062013	positive regulation of small molecule metabolic process	84	99	1.77e-02
GO:BP	GO:0071230	cellular response to amino acid stimulus	58	66	1.77e-02
GO:BP	GO:0060415	muscle tissue morphogenesis	54	61	1.78e-02
GO:BP	GO:1903530	regulation of secretion by cell	286	366	1.81e-02
GO:BP	GO:0048640	negative regulation of developmental growth	73	85	1.82e-02
GO:BP	GO:0031667	response to nutrient levels	277	354	1.85e-02
GO:BP	GO:0051251	positive regulation of lymphocyte activation	150	185	1.87e-02
GO:BP	GO:0001704	formation of primary germ layer	80	94	1.90e-02
GO:BP	GO:0140747	regulation of ncRNA transcription	69	80	1.93e-02
GO:BP	GO:0060675	ureteric bud morphogenesis	41	45	1.94e-02
GO:BP	GO:0090183	regulation of kidney development	20	20	1.96e-02
GO:BP	GO:0002053	positive regulation of mesenchymal cell proliferation	20	20	1.96e-02
GO:BP	GO:0014070	response to organic cyclic compound	463	606	2.10e-02
GO:BP	GO:0090497	mesenchymal cell migration	45	50	2.10e-02
GO:BP	GO:0072210	metanephric nephron development	26	27	2.11e-02
GO:BP	GO:1904385	cellular response to angiotensin	26	27	2.11e-02
GO:BP	GO:0060416	response to growth hormone	26	27	2.11e-02
GO:BP	GO:1904646	cellular response to amyloid-beta	26	27	2.11e-02
GO:BP	GO:0055008	cardiac muscle tissue morphogenesis	49	55	2.16e-02
GO:BP	GO:0046578	regulation of Ras protein signal transduction	36	39	2.16e-02
GO:BP	GO:0021536	diencephalon development	36	39	2.16e-02
GO:BP	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	49	55	2.16e-02
GO:BP	GO:0051983	regulation of chromosome segregation	100	120	2.17e-02
GO:BP	GO:0014909	smooth muscle cell migration	53	60	2.17e-02
GO:BP	GO:0051301	cell division	415	541	2.17e-02
GO:BP	GO:0046683	response to organophosphorus	79	93	2.24e-02
GO:BP	GO:0001508	action potential	86	102	2.26e-02
GO:BP	GO:0050801	monoatomic ion homeostasis	315	406	2.34e-02
GO:BP	GO:0009792	embryo development ending in birth or egg hatching	400	521	2.36e-02
GO:BP	GO:0007548	sex differentiation	145	179	2.36e-02
GO:BP	GO:0030217	T cell differentiation	148	183	2.41e-02
GO:BP	GO:0006638	neutral lipid metabolic process	75	88	2.41e-02
GO:BP	GO:0061387	regulation of extent of cell growth	75	88	2.41e-02
GO:BP	GO:1902903	regulation of supramolecular fiber organization	239	304	2.42e-02
GO:BP	GO:0031644	regulation of nervous system process	64	74	2.42e-02
GO:BP	GO:0051649	establishment of localization in cell	1161	1566	2.42e-02
GO:BP	GO:0014074	response to purine-containing compound	89	106	2.43e-02
GO:BP	GO:0008277	regulation of G protein-coupled receptor signaling pathway	82	97	2.44e-02
GO:BP	GO:0044772	mitotic cell cycle phase transition	297	382	2.48e-02
GO:BP	GO:0035264	multicellular organism growth	99	119	2.51e-02
GO:BP	GO:0035051	cardiocyte differentiation	109	132	2.51e-02
GO:BP	GO:0045685	regulation of glial cell differentiation	44	49	2.57e-02
GO:BP	GO:0046942	carboxylic acid transport	163	203	2.57e-02
GO:BP	GO:0090263	positive regulation of canonical Wnt signaling pathway	71	83	2.57e-02
GO:BP	GO:0086003	cardiac muscle cell contraction	56	64	2.60e-02
GO:BP	GO:0060740	prostate gland epithelium morphogenesis	19	19	2.62e-02
GO:BP	GO:0010878	cholesterol storage	19	19	2.62e-02
GO:BP	GO:0060512	prostate gland morphogenesis	19	19	2.62e-02
GO:BP	GO:0048566	embryonic digestive tract development	19	19	2.62e-02
GO:BP	GO:0071378	cellular response to growth hormone stimulus	19	19	2.62e-02
GO:BP	GO:0003184	pulmonary valve morphogenesis	19	19	2.62e-02
GO:BP	GO:2000027	regulation of animal organ morphogenesis	52	59	2.63e-02
GO:BP	GO:0046503	glycerolipid catabolic process	35	38	2.70e-02
GO:BP	GO:0045668	negative regulation of osteoblast differentiation	35	38	2.70e-02
GO:BP	GO:0002066	columnar/cuboidal epithelial cell development	35	38	2.70e-02
GO:BP	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	35	38	2.70e-02
GO:BP	GO:0050773	regulation of dendrite development	67	78	2.71e-02
GO:BP	GO:0030510	regulation of BMP signaling pathway	67	78	2.71e-02
GO:BP	GO:0009991	response to extracellular stimulus	293	377	2.71e-02
GO:BP	GO:0010092	specification of animal organ identity	25	26	2.72e-02
GO:BP	GO:0000278	mitotic cell cycle	577	763	2.73e-02
GO:BP	GO:0070371	ERK1 and ERK2 cascade	156	194	2.80e-02
GO:BP	GO:0006639	acylglycerol metabolic process	74	87	2.81e-02
GO:BP	GO:0007613	memory	74	87	2.81e-02
GO:BP	GO:0043009	chordate embryonic development	389	507	2.83e-02
GO:BP	GO:0030501	positive regulation of bone mineralization	30	32	2.85e-02
GO:BP	GO:0071604	transforming growth factor beta production	30	32	2.85e-02
GO:BP	GO:0072583	clathrin-dependent endocytosis	39	43	3.00e-02
GO:BP	GO:0072659	protein localization to plasma membrane	189	238	3.02e-02
GO:BP	GO:0044784	metaphase/anaphase transition of cell cycle	77	91	3.08e-02
GO:BP	GO:0034767	positive regulation of monoatomic ion transmembrane transport	77	91	3.08e-02
GO:BP	GO:0006637	acyl-CoA metabolic process	55	63	3.11e-02
GO:BP	GO:0002688	regulation of leukocyte chemotaxis	55	63	3.11e-02
GO:BP	GO:0035383	thioester metabolic process	55	63	3.11e-02
GO:BP	GO:0002694	regulation of leukocyte activation	245	313	3.13e-02
GO:BP	GO:0051058	negative regulation of small GTPase mediated signal transduction	43	48	3.15e-02
GO:BP	GO:0008219	cell death	1056	1423	3.15e-02
GO:BP	GO:0022408	negative regulation of cell-cell adhesion	94	113	3.16e-02
GO:BP	GO:0008543	fibroblast growth factor receptor signaling pathway	51	58	3.17e-02
GO:BP	GO:0033674	positive regulation of kinase activity	158	197	3.17e-02
GO:BP	GO:0048844	artery morphogenesis	51	58	3.17e-02
GO:BP	GO:0012501	programmed cell death	1053	1419	3.20e-02
GO:BP	GO:0032526	response to retinoic acid	66	77	3.20e-02
GO:BP	GO:0033993	response to lipid	437	573	3.31e-02
GO:BP	GO:0099504	synaptic vesicle cycle	123	151	3.37e-02
GO:BP	GO:0003176	aortic valve development	34	37	3.39e-02
GO:BP	GO:0070169	positive regulation of biomineral tissue development	34	37	3.39e-02
GO:BP	GO:1902305	regulation of sodium ion transmembrane transport	34	37	3.39e-02
GO:BP	GO:0009611	response to wounding	296	382	3.43e-02
GO:BP	GO:0016049	cell growth	296	382	3.43e-02
GO:BP	GO:0045926	negative regulation of growth	148	184	3.44e-02
GO:BP	GO:1903169	regulation of calcium ion transmembrane transport	90	108	3.45e-02
GO:BP	GO:0035336	long-chain fatty-acyl-CoA metabolic process	18	18	3.49e-02
GO:BP	GO:0010743	regulation of macrophage derived foam cell differentiation	18	18	3.49e-02
GO:BP	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	18	18	3.49e-02
GO:BP	GO:0060396	growth hormone receptor signaling pathway	18	18	3.49e-02
GO:BP	GO:0055080	monoatomic cation homeostasis	310	401	3.49e-02
GO:BP	GO:0006909	phagocytosis	113	138	3.49e-02
GO:BP	GO:1902905	positive regulation of supramolecular fiber organization	113	138	3.49e-02
GO:BP	GO:0035025	positive regulation of Rho protein signal transduction	24	25	3.50e-02
GO:BP	GO:0099171	presynaptic modulation of chemical synaptic transmission	24	25	3.50e-02
GO:BP	GO:0060351	cartilage development involved in endochondral bone morphogenesis	24	25	3.50e-02
GO:BP	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	76	90	3.57e-02
GO:BP	GO:0015849	organic acid transport	163	204	3.57e-02
GO:BP	GO:0007219	Notch signaling pathway	116	142	3.58e-02
GO:BP	GO:1902904	negative regulation of supramolecular fiber organization	103	125	3.58e-02
GO:BP	GO:0071634	regulation of transforming growth factor beta production	29	31	3.59e-02
GO:BP	GO:0045687	positive regulation of glial cell differentiation	29	31	3.59e-02
GO:BP	GO:0030857	negative regulation of epithelial cell differentiation	29	31	3.59e-02
GO:BP	GO:1904645	response to amyloid-beta	29	31	3.59e-02
GO:BP	GO:0060688	regulation of morphogenesis of a branching structure	29	31	3.59e-02
GO:BP	GO:0106106	cold-induced thermogenesis	93	112	3.59e-02
GO:BP	GO:0019058	viral life cycle	184	232	3.64e-02
GO:BP	GO:0051591	response to cAMP	54	62	3.68e-02
GO:BP	GO:0070372	regulation of ERK1 and ERK2 cascade	141	175	3.71e-02
GO:BP	GO:0030705	cytoskeleton-dependent intracellular transport	144	179	3.77e-02
GO:BP	GO:0051899	membrane depolarization	50	57	3.78e-02
GO:BP	GO:0097009	energy homeostasis	50	57	3.78e-02
GO:BP	GO:0032147	activation of protein kinase activity	50	57	3.78e-02
GO:BP	GO:0033555	multicellular organismal response to stress	50	57	3.78e-02
GO:BP	GO:0009953	dorsal/ventral pattern formation	42	47	3.79e-02
GO:BP	GO:0051653	spindle localization	46	52	3.82e-02
GO:BP	GO:0001708	cell fate specification	46	52	3.82e-02
GO:BP	GO:0048863	stem cell differentiation	153	191	3.87e-02
GO:BP	GO:0006629	lipid metabolic process	692	923	3.92e-02
GO:BP	GO:0033045	regulation of sister chromatid segregation	82	98	4.09e-02
GO:BP	GO:0120161	regulation of cold-induced thermogenesis	92	111	4.16e-02
GO:BP	GO:0048813	dendrite morphogenesis	92	111	4.16e-02
GO:BP	GO:0010876	lipid localization	233	298	4.16e-02
GO:BP	GO:0051495	positive regulation of cytoskeleton organization	118	145	4.17e-02
GO:BP	GO:0038179	neurotrophin signaling pathway	33	36	4.19e-02
GO:BP	GO:0044272	sulfur compound biosynthetic process	105	128	4.24e-02
GO:BP	GO:1903708	positive regulation of hemopoiesis	95	115	4.35e-02
GO:BP	GO:1902107	positive regulation of leukocyte differentiation	95	115	4.35e-02
GO:BP	GO:0046649	lymphocyte activation	341	444	4.38e-02
GO:BP	GO:0035567	non-canonical Wnt signaling pathway	53	61	4.43e-02
GO:BP	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	53	61	4.43e-02
GO:BP	GO:0042303	molting cycle	64	75	4.44e-02
GO:BP	GO:0042633	hair cycle	64	75	4.44e-02
GO:BP	GO:0045453	bone resorption	37	41	4.48e-02
GO:BP	GO:0048872	homeostasis of number of cells	176	222	4.48e-02
GO:BP	GO:0021952	central nervous system projection neuron axonogenesis	23	24	4.48e-02
GO:BP	GO:0022029	telencephalon cell migration	37	41	4.48e-02
GO:BP	GO:0010812	negative regulation of cell-substrate adhesion	37	41	4.48e-02
GO:BP	GO:0003272	endocardial cushion formation	23	24	4.48e-02
GO:BP	GO:0051894	positive regulation of focal adhesion assembly	23	24	4.48e-02
GO:BP	GO:0061383	trabecula morphogenesis	37	41	4.48e-02
GO:BP	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	170	214	4.48e-02
GO:BP	GO:0045124	regulation of bone resorption	23	24	4.48e-02
GO:BP	GO:0051146	striated muscle cell differentiation	185	234	4.48e-02
GO:BP	GO:2000737	negative regulation of stem cell differentiation	23	24	4.48e-02
GO:BP	GO:0050919	negative chemotaxis	37	41	4.48e-02
GO:BP	GO:0002431	Fc receptor mediated stimulatory signaling pathway	23	24	4.48e-02
GO:BP	GO:0046661	male sex differentiation	88	106	4.50e-02
GO:BP	GO:0001937	negative regulation of endothelial cell proliferation	28	30	4.50e-02
GO:BP	GO:0060914	heart formation	28	30	4.50e-02
GO:BP	GO:0001974	blood vessel remodeling	28	30	4.50e-02
GO:BP	GO:0060323	head morphogenesis	28	30	4.50e-02
GO:BP	GO:1901990	regulation of mitotic cell cycle phase transition	229	293	4.51e-02
GO:BP	GO:0016032	viral process	255	328	4.53e-02
GO:BP	GO:0034505	tooth mineralization	17	17	4.53e-02
GO:BP	GO:0009065	glutamine family amino acid catabolic process	17	17	4.53e-02
GO:BP	GO:0003215	cardiac right ventricle morphogenesis	17	17	4.53e-02
GO:BP	GO:0032528	microvillus organization	17	17	4.53e-02
GO:BP	GO:0060977	coronary vasculature morphogenesis	17	17	4.53e-02
GO:BP	GO:0050771	negative regulation of axonogenesis	45	51	4.57e-02
GO:BP	GO:0006865	amino acid transport	81	97	4.64e-02
GO:BP	GO:0006470	protein dephosphorylation	142	177	4.64e-02
GO:BP	GO:0070482	response to oxygen levels	208	265	4.71e-02
GO:BP	GO:0006869	lipid transport	205	261	4.73e-02
GO:BP	GO:0051494	negative regulation of cytoskeleton organization	104	127	4.74e-02
GO:BP	GO:0008593	regulation of Notch signaling pathway	67	79	4.76e-02
GO:BP	GO:0035303	regulation of dephosphorylation	67	79	4.76e-02
GO:BP	GO:0002573	myeloid leukocyte differentiation	123	152	4.81e-02
GO:BP	GO:0006887	exocytosis	187	237	4.84e-02
GO:BP	GO:0001942	hair follicle development	56	65	4.93e-02

LRnomtable %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in LR neargenes") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in LR neargenes
source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:05200	Pathways in cancer	328	391	3.55e-07
KEGG	KEGG:04360	Axon guidance	137	155	2.59e-05
KEGG	KEGG:05205	Proteoglycans in cancer	142	162	3.40e-05
KEGG	KEGG:04971	Gastric acid secretion	50	51	4.56e-05
KEGG	KEGG:04310	Wnt signaling pathway	118	133	4.79e-05
KEGG	KEGG:04024	cAMP signaling pathway	129	147	5.16e-05
KEGG	KEGG:04510	Focal adhesion	146	169	7.29e-05
KEGG	KEGG:04015	Rap1 signaling pathway	140	162	8.94e-05
KEGG	KEGG:04970	Salivary secretion	52	54	8.94e-05
KEGG	KEGG:04014	Ras signaling pathway	141	164	1.28e-04
KEGG	KEGG:04520	Adherens junction	76	83	1.28e-04
KEGG	KEGG:04022	cGMP-PKG signaling pathway	113	129	1.52e-04
KEGG	KEGG:04550	Signaling pathways regulating pluripotency of stem cells	90	101	2.61e-04
KEGG	KEGG:04611	Platelet activation	79	88	4.18e-04
KEGG	KEGG:04020	Calcium signaling pathway	137	161	4.18e-04
KEGG	KEGG:04810	Regulation of actin cytoskeleton	143	169	4.86e-04
KEGG	KEGG:05163	Human cytomegalovirus infection	135	160	9.35e-04
KEGG	KEGG:04928	Parathyroid hormone synthesis, secretion and action	70	78	9.35e-04
KEGG	KEGG:04924	Renin secretion	47	50	9.35e-04
KEGG	KEGG:04911	Insulin secretion	57	62	9.35e-04
KEGG	KEGG:05146	Amoebiasis	57	62	9.35e-04
KEGG	KEGG:04512	ECM-receptor interaction	60	66	1.17e-03
KEGG	KEGG:04270	Vascular smooth muscle contraction	81	92	1.17e-03
KEGG	KEGG:04010	MAPK signaling pathway	189	231	1.24e-03
KEGG	KEGG:04925	Aldosterone synthesis and secretion	67	75	1.55e-03
KEGG	KEGG:04916	Melanogenesis	67	75	1.55e-03
KEGG	KEGG:04918	Thyroid hormone synthesis	49	53	1.59e-03
KEGG	KEGG:04927	Cortisol synthesis and secretion	43	46	2.09e-03
KEGG	KEGG:04972	Pancreatic secretion	52	57	2.29e-03
KEGG	KEGG:04151	PI3K-Akt signaling pathway	202	250	2.43e-03
KEGG	KEGG:04148	Efferocytosis	102	120	2.50e-03
KEGG	KEGG:04933	AGE-RAGE signaling pathway in diabetic complications	76	87	2.50e-03
KEGG	KEGG:04390	Hippo signaling pathway	109	129	2.50e-03
KEGG	KEGG:04974	Protein digestion and absorption	51	56	2.53e-03
KEGG	KEGG:04261	Adrenergic signaling in cardiomyocytes	105	124	2.57e-03
KEGG	KEGG:05165	Human papillomavirus infection	202	252	4.72e-03
KEGG	KEGG:04728	Dopaminergic synapse	83	97	5.30e-03
KEGG	KEGG:04713	Circadian entrainment	60	68	5.44e-03
KEGG	KEGG:04976	Bile secretion	38	41	6.05e-03
KEGG	KEGG:04750	Inflammatory mediator regulation of TRP channels	63	72	6.33e-03
KEGG	KEGG:05412	Arrhythmogenic right ventricular cardiomyopathy	59	67	6.33e-03
KEGG	KEGG:04926	Relaxin signaling pathway	85	100	6.37e-03
KEGG	KEGG:04961	Endocrine and other factor-regulated calcium reabsorption	37	40	7.11e-03
KEGG	KEGG:04350	TGF-beta signaling pathway	77	90	7.11e-03
KEGG	KEGG:05417	Lipid and atherosclerosis	118	143	7.35e-03
KEGG	KEGG:04658	Th1 and Th2 cell differentiation	45	50	8.33e-03
KEGG	KEGG:04072	Phospholipase D signaling pathway	90	107	8.33e-03
KEGG	KEGG:04730	Long-term depression	36	39	8.49e-03
KEGG	KEGG:04630	JAK-STAT signaling pathway	71	83	1.00e-02
KEGG	KEGG:04340	Hedgehog signaling pathway	44	49	1.00e-02
KEGG	KEGG:04935	Growth hormone synthesis, secretion and action	81	96	1.09e-02
KEGG	KEGG:04919	Thyroid hormone signaling pathway	88	105	1.09e-02
KEGG	KEGG:05418	Fluid shear stress and atherosclerosis	91	109	1.13e-02
KEGG	KEGG:05414	Dilated cardiomyopathy	70	82	1.13e-02
KEGG	KEGG:05167	Kaposi sarcoma-associated herpesvirus infection	110	134	1.28e-02
KEGG	KEGG:04915	Estrogen signaling pathway	76	90	1.34e-02
KEGG	KEGG:04670	Leukocyte transendothelial migration	65	76	1.41e-02
KEGG	KEGG:05135	Yersinia infection	89	107	1.46e-02
KEGG	KEGG:05207	Chemical carcinogenesis - receptor activation	108	132	1.63e-02
KEGG	KEGG:04659	Th17 cell differentiation	52	60	2.00e-02
KEGG	KEGG:04514	Cell adhesion molecules	59	69	2.11e-02
KEGG	KEGG:04921	Oxytocin signaling pathway	93	113	2.12e-02
KEGG	KEGG:04371	Apelin signaling pathway	86	104	2.23e-02
KEGG	KEGG:04725	Cholinergic synapse	69	82	2.25e-02
KEGG	KEGG:04071	Sphingolipid signaling pathway	85	103	2.51e-02
KEGG	KEGG:00000	KEGG root term	3931	5451	2.51e-02
KEGG	KEGG:05210	Colorectal cancer	68	81	2.57e-02
KEGG	KEGG:04726	Serotonergic synapse	50	58	2.69e-02
KEGG	KEGG:04660	T cell receptor signaling pathway	70	84	3.20e-02
KEGG	KEGG:00512	Mucin type O-glycan biosynthesis	20	21	3.56e-02
KEGG	KEGG:03320	PPAR signaling pathway	41	47	3.59e-02
KEGG	KEGG:04625	C-type lectin receptor signaling pathway	62	74	3.77e-02
KEGG	KEGG:04724	Glutamatergic synapse	62	74	3.77e-02
KEGG	KEGG:05170	Human immunodeficiency virus 1 infection	119	149	3.95e-02
KEGG	KEGG:04720	Long-term potentiation	44	51	3.96e-02
KEGG	KEGG:05206	MicroRNAs in cancer	115	144	4.31e-02
KEGG	KEGG:04923	Regulation of lipolysis in adipocytes	36	41	4.31e-02
KEGG	KEGG:04742	Taste transduction	19	20	4.32e-02
KEGG	KEGG:05410	Hypertrophic cardiomyopathy	64	77	4.43e-02
KEGG	KEGG:04934	Cushing syndrome	96	119	4.45e-02
KEGG	KEGG:05130	Pathogenic Escherichia coli infection	114	143	4.67e-02
KEGG	KEGG:01521	EGFR tyrosine kinase inhibitor resistance	60	72	4.78e-02
KEGG	KEGG:05032	Morphine addiction	46	54	4.96e-02

NR response genes

# NR_resgenes <- gost(query = NR_NG_list$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(NR_resgenes,"data/GO_KEGG_analysis/NR_resgenes.RDS")

NRnom <- gostplot(NR_resgenes, capped = FALSE, interactive = TRUE)
# NRnom

NRnomtable <- NR_resgenes$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

NRnomtable %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in NR neargenes" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in NR neargenes
source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0007275	multicellular organism development	3082	3170	4.30e-05
GO:BP	GO:0032501	multicellular organismal process	4362	4504	4.30e-05
GO:BP	GO:0048523	negative regulation of cellular process	3446	3550	4.40e-05
GO:BP	GO:0051716	cellular response to stimulus	4491	4640	4.44e-05
GO:BP	GO:0007010	cytoskeleton organization	1127	1146	7.38e-05
GO:BP	GO:0048731	system development	2645	2719	7.49e-05
GO:BP	GO:0048856	anatomical structure development	3748	3867	7.49e-05
GO:BP	GO:0050896	response to stimulus	5196	5379	8.02e-05
GO:BP	GO:0050794	regulation of cellular process	6888	7153	2.38e-04
GO:BP	GO:0065007	biological regulation	7441	7734	3.22e-04
GO:BP	GO:0007154	cell communication	3855	3983	3.67e-04
GO:BP	GO:0048519	negative regulation of biological process	3645	3764	3.67e-04
GO:BP	GO:0009653	anatomical structure morphogenesis	1799	1844	3.67e-04
GO:BP	GO:0050789	regulation of biological process	7232	7516	3.99e-04
GO:BP	GO:0023052	signaling	3792	3918	4.48e-04
GO:BP	GO:0032502	developmental process	4042	4179	4.62e-04
GO:BP	GO:0008150	biological_process	10770	11244	6.46e-04
GO:BP	GO:0051128	regulation of cellular component organization	1815	1862	6.81e-04
GO:BP	GO:0071495	cellular response to endogenous stimulus	1016	1035	6.93e-04
GO:BP	GO:0050793	regulation of developmental process	1655	1697	1.16e-03
GO:BP	GO:0007165	signal transduction	3495	3611	1.16e-03
GO:BP	GO:0023051	regulation of signaling	2368	2438	1.48e-03
GO:BP	GO:0048583	regulation of response to stimulus	2636	2717	1.58e-03
GO:BP	GO:0009966	regulation of signal transduction	2106	2166	1.65e-03
GO:BP	GO:0007399	nervous system development	1729	1775	2.13e-03
GO:BP	GO:0016477	cell migration	991	1011	2.73e-03
GO:BP	GO:0022008	neurogenesis	1223	1251	2.76e-03
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	601	609	2.83e-03
GO:BP	GO:0000902	cell morphogenesis	702	713	2.92e-03
GO:BP	GO:0010646	regulation of cell communication	2372	2444	2.95e-03
GO:BP	GO:0030029	actin filament-based process	631	640	3.04e-03
GO:BP	GO:0048518	positive regulation of biological process	4153	4301	3.42e-03
GO:BP	GO:0009888	tissue development	1316	1348	3.77e-03
GO:BP	GO:0048522	positive regulation of cellular process	3820	3954	4.19e-03
GO:BP	GO:0048699	generation of neurons	1053	1076	4.37e-03
GO:BP	GO:0007155	cell adhesion	922	941	6.18e-03
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	821	837	8.05e-03
GO:BP	GO:0009719	response to endogenous stimulus	1169	1197	8.05e-03
GO:BP	GO:0016043	cellular component organization	4630	4802	8.05e-03
GO:BP	GO:0009987	cellular process	10236	10686	8.78e-03
GO:BP	GO:0030036	actin cytoskeleton organization	558	566	8.78e-03
GO:BP	GO:0030182	neuron differentiation	992	1014	8.85e-03
GO:BP	GO:0048513	animal organ development	1946	2004	1.02e-02
GO:BP	GO:0065008	regulation of biological quality	1839	1893	1.13e-02
GO:BP	GO:0035295	tube development	772	787	1.14e-02
GO:BP	GO:0048870	cell motility	1094	1120	1.14e-02
GO:BP	GO:0048869	cellular developmental process	2714	2804	1.27e-02
GO:BP	GO:0030154	cell differentiation	2713	2803	1.27e-02
GO:BP	GO:0007267	cell-cell signaling	1057	1082	1.32e-02
GO:BP	GO:0007015	actin filament organization	354	357	1.44e-02
GO:BP	GO:0051239	regulation of multicellular organismal process	1868	1924	1.54e-02
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	260	261	1.76e-02
GO:BP	GO:0048468	cell development	1831	1886	1.89e-02
GO:BP	GO:0031589	cell-substrate adhesion	257	258	1.90e-02
GO:BP	GO:1901700	response to oxygen-containing compound	1067	1093	1.90e-02
GO:BP	GO:0097435	supramolecular fiber organization	622	633	2.02e-02
GO:BP	GO:0032970	regulation of actin filament-based process	298	300	2.24e-02
GO:BP	GO:0035556	intracellular signal transduction	1893	1951	2.27e-02
GO:BP	GO:0032989	cellular anatomical entity morphogenesis	578	588	2.81e-02
GO:BP	GO:0071840	cellular component organization or biogenesis	4802	4988	4.57e-02
GO:BP	GO:0023056	positive regulation of signaling	1189	1221	4.59e-02
GO:BP	GO:0006996	organelle organization	2721	2815	4.63e-02
GO:BP	GO:0010647	positive regulation of cell communication	1186	1218	4.77e-02

NRnomtable %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in NR neargenes") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in NR neargenes
source	term_id	term_name	intersection_size	term_size	p_value
NA	NA	NA	NA	NA	NA
:——	:——-	:———	—————–:	———:	:——-

sessionInfo()

R version 4.3.1 (2023-06-16 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)

Matrix products: default


locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

time zone: America/Chicago
tzcode source: internal

attached base packages:
[1] grid      stats4    stats     graphics  grDevices utils     datasets 
[8] methods   base     

other attached packages:
 [1] biomaRt_2.58.2                          
 [2] ggpubr_0.6.0                            
 [3] BiocParallel_1.36.0                     
 [4] scales_1.3.0                            
 [5] VennDiagram_1.7.3                       
 [6] futile.logger_1.4.3                     
 [7] gridExtra_2.3                           
 [8] ggfortify_0.4.17                        
 [9] edgeR_4.0.16                            
[10] limma_3.58.1                            
[11] rtracklayer_1.62.0                      
[12] org.Hs.eg.db_3.18.0                     
[13] TxDb.Hsapiens.UCSC.hg38.knownGene_3.18.0
[14] GenomicFeatures_1.54.4                  
[15] AnnotationDbi_1.64.1                    
[16] Biobase_2.62.0                          
[17] GenomicRanges_1.54.1                    
[18] GenomeInfoDb_1.38.8                     
[19] IRanges_2.36.0                          
[20] S4Vectors_0.40.2                        
[21] BiocGenerics_0.48.1                     
[22] ChIPseeker_1.38.0                       
[23] gprofiler2_0.2.3                        
[24] RColorBrewer_1.1-3                      
[25] broom_1.0.5                             
[26] kableExtra_1.4.0                        
[27] lubridate_1.9.3                         
[28] forcats_1.0.0                           
[29] stringr_1.5.1                           
[30] dplyr_1.1.4                             
[31] purrr_1.0.2                             
[32] readr_2.1.5                             
[33] tidyr_1.3.1                             
[34] tibble_3.2.1                            
[35] ggplot2_3.5.1                           
[36] tidyverse_2.0.0                         
[37] workflowr_1.7.1                         

loaded via a namespace (and not attached):
  [1] fs_1.6.4                               
  [2] matrixStats_1.3.0                      
  [3] bitops_1.0-7                           
  [4] enrichplot_1.22.0                      
  [5] HDO.db_0.99.1                          
  [6] httr_1.4.7                             
  [7] tools_4.3.1                            
  [8] backports_1.4.1                        
  [9] utf8_1.2.4                             
 [10] R6_2.5.1                               
 [11] lazyeval_0.2.2                         
 [12] withr_3.0.0                            
 [13] prettyunits_1.2.0                      
 [14] cli_3.6.2                              
 [15] formatR_1.14                           
 [16] scatterpie_0.2.2                       
 [17] labeling_0.4.3                         
 [18] sass_0.4.9                             
 [19] Rsamtools_2.18.0                       
 [20] systemfonts_1.0.6                      
 [21] yulab.utils_0.1.4                      
 [22] DOSE_3.28.2                            
 [23] svglite_2.1.3                          
 [24] plotrix_3.8-4                          
 [25] rstudioapi_0.16.0                      
 [26] RSQLite_2.3.6                          
 [27] generics_0.1.3                         
 [28] gridGraphics_0.5-1                     
 [29] TxDb.Hsapiens.UCSC.hg19.knownGene_3.2.2
 [30] BiocIO_1.12.0                          
 [31] crosstalk_1.2.1                        
 [32] vroom_1.6.5                            
 [33] gtools_3.9.5                           
 [34] car_3.1-2                              
 [35] GO.db_3.18.0                           
 [36] Matrix_1.6-5                           
 [37] fansi_1.0.6                            
 [38] abind_1.4-5                            
 [39] lifecycle_1.0.4                        
 [40] whisker_0.4.1                          
 [41] yaml_2.3.8                             
 [42] carData_3.0-5                          
 [43] SummarizedExperiment_1.32.0            
 [44] gplots_3.1.3.1                         
 [45] qvalue_2.34.0                          
 [46] SparseArray_1.2.4                      
 [47] BiocFileCache_2.10.2                   
 [48] blob_1.2.4                             
 [49] promises_1.3.0                         
 [50] crayon_1.5.2                           
 [51] lattice_0.22-6                         
 [52] cowplot_1.1.3                          
 [53] KEGGREST_1.42.0                        
 [54] pillar_1.9.0                           
 [55] knitr_1.46                             
 [56] fgsea_1.28.0                           
 [57] rjson_0.2.21                           
 [58] boot_1.3-30                            
 [59] codetools_0.2-20                       
 [60] fastmatch_1.1-4                        
 [61] glue_1.7.0                             
 [62] getPass_0.2-4                          
 [63] ggfun_0.1.4                            
 [64] data.table_1.15.4                      
 [65] vctrs_0.6.5                            
 [66] png_0.1-8                              
 [67] treeio_1.26.0                          
 [68] gtable_0.3.5                           
 [69] cachem_1.0.8                           
 [70] xfun_0.43                              
 [71] S4Arrays_1.2.1                         
 [72] mime_0.12                              
 [73] tidygraph_1.3.1                        
 [74] statmod_1.5.0                          
 [75] interactiveDisplayBase_1.40.0          
 [76] nlme_3.1-164                           
 [77] ggtree_3.10.1                          
 [78] bit64_4.0.5                            
 [79] progress_1.2.3                         
 [80] filelock_1.0.3                         
 [81] rprojroot_2.0.4                        
 [82] bslib_0.7.0                            
 [83] KernSmooth_2.23-22                     
 [84] colorspace_2.1-0                       
 [85] DBI_1.2.2                              
 [86] tidyselect_1.2.1                       
 [87] processx_3.8.4                         
 [88] bit_4.0.5                              
 [89] compiler_4.3.1                         
 [90] curl_5.2.1                             
 [91] git2r_0.33.0                           
 [92] xml2_1.3.6                             
 [93] DelayedArray_0.28.0                    
 [94] plotly_4.10.4                          
 [95] shadowtext_0.1.3                       
 [96] caTools_1.18.2                         
 [97] callr_3.7.6                            
 [98] rappdirs_0.3.3                         
 [99] digest_0.6.35                          
[100] rmarkdown_2.26                         
[101] XVector_0.42.0                         
[102] htmltools_0.5.8.1                      
[103] pkgconfig_2.0.3                        
[104] MatrixGenerics_1.14.0                  
[105] highr_0.10                             
[106] dbplyr_2.5.0                           
[107] fastmap_1.1.1                          
[108] rlang_1.1.3                            
[109] htmlwidgets_1.6.4                      
[110] shiny_1.8.1.1                          
[111] farver_2.1.1                           
[112] jquerylib_0.1.4                        
[113] jsonlite_1.8.8                         
[114] GOSemSim_2.28.1                        
[115] RCurl_1.98-1.14                        
[116] magrittr_2.0.3                         
[117] GenomeInfoDbData_1.2.11                
[118] ggplotify_0.1.2                        
[119] patchwork_1.2.0                        
[120] munsell_0.5.1                          
[121] Rcpp_1.0.12                            
[122] ape_5.8                                
[123] viridis_0.6.5                          
[124] stringi_1.8.3                          
[125] ggraph_2.2.1                           
[126] zlibbioc_1.48.2                        
[127] MASS_7.3-60.0.1                        
[128] AnnotationHub_3.10.1                   
[129] plyr_1.8.9                             
[130] parallel_4.3.1                         
[131] ggrepel_0.9.5                          
[132] Biostrings_2.70.3                      
[133] graphlayouts_1.1.1                     
[134] splines_4.3.1                          
[135] hms_1.1.3                              
[136] locfit_1.5-9.9                         
[137] ps_1.7.6                               
[138] igraph_2.0.3                           
[139] ggsignif_0.6.4                         
[140] reshape2_1.4.4                         
[141] futile.options_1.0.1                   
[142] BiocVersion_3.18.1                     
[143] XML_3.99-0.16.1                        
[144] evaluate_0.23                          
[145] lambda.r_1.2.4                         
[146] BiocManager_1.30.22                    
[147] tzdb_0.4.0                             
[148] tweenr_2.0.3                           
[149] httpuv_1.6.15                          
[150] polyclip_1.10-6                        
[151] ggforce_0.4.2                          
[152] xtable_1.8-4                           
[153] restfulr_0.0.15                        
[154] tidytree_0.4.6                         
[155] rstatix_0.7.2                          
[156] later_1.3.2                            
[157] viridisLite_0.4.2                      
[158] aplot_0.2.2                            
[159] memoise_2.0.1                          
[160] GenomicAlignments_1.38.2               
[161] timechange_0.3.0