Last updated: 2025-05-08

Checks: 7 0

Knit directory: ATAC_learning/

This reproducible R Markdown analysis was created with workflowr (version 1.7.1). The Checks tab describes the reproducibility checks that were applied when the results were created. The Past versions tab lists the development history.

R Markdown file: up-to-date

Great! Since the R Markdown file has been committed to the Git repository, you know the exact version of the code that produced these results.

Environment: empty

Great job! The global environment was empty. Objects defined in the global environment can affect the analysis in your R Markdown file in unknown ways. For reproduciblity it’s best to always run the code in an empty environment.

Seed: set.seed(20231016)

The command set.seed(20231016) was run prior to running the code in the R Markdown file. Setting a seed ensures that any results that rely on randomness, e.g. subsampling or permutations, are reproducible.

Session information: recorded

Great job! Recording the operating system, R version, and package versions is critical for reproducibility.

Cache: none

Nice! There were no cached chunks for this analysis, so you can be confident that you successfully produced the results during this run.

File paths: relative

Great job! Using relative paths to the files within your workflowr project makes it easier to run your code on other machines.

Repository version: 0fb8e8b

Great! You are using Git for version control. Tracking code development and connecting the code version to the results is critical for reproducibility.

The results in this page were generated with repository version 0fb8e8b. See the Past versions tab to see a history of the changes made to the R Markdown and HTML files.

Note that you need to be careful to ensure that all relevant files for the analysis have been committed to Git prior to generating the results (you can use wflow_publish or wflow_git_commit). workflowr only checks the R Markdown file, but you know if there are other scripts or data files that it depends on. Below is the status of the Git repository when the results were generated: 


Ignored files:
    Ignored:    .RData
    Ignored:    .Rhistory
    Ignored:    .Rproj.user/
    Ignored:    data/ACresp_SNP_table.csv
    Ignored:    data/ARR_SNP_table.csv
    Ignored:    data/All_merged_peaks.tsv
    Ignored:    data/CAD_gwas_dataframe.RDS
    Ignored:    data/CTX_SNP_table.csv
    Ignored:    data/Collapsed_expressed_NG_peak_table.csv
    Ignored:    data/DEG_toplist_sep_n45.RDS
    Ignored:    data/FRiP_first_run.txt
    Ignored:    data/Final_four_data/
    Ignored:    data/Frip_1_reads.csv
    Ignored:    data/Frip_2_reads.csv
    Ignored:    data/Frip_3_reads.csv
    Ignored:    data/Frip_4_reads.csv
    Ignored:    data/Frip_5_reads.csv
    Ignored:    data/Frip_6_reads.csv
    Ignored:    data/GO_KEGG_analysis/
    Ignored:    data/HF_SNP_table.csv
    Ignored:    data/Ind1_75DA24h_dedup_peaks.csv
    Ignored:    data/Ind1_TSS_peaks.RDS
    Ignored:    data/Ind1_firstfragment_files.txt
    Ignored:    data/Ind1_fragment_files.txt
    Ignored:    data/Ind1_peaks_list.RDS
    Ignored:    data/Ind1_summary.txt
    Ignored:    data/Ind2_TSS_peaks.RDS
    Ignored:    data/Ind2_fragment_files.txt
    Ignored:    data/Ind2_peaks_list.RDS
    Ignored:    data/Ind2_summary.txt
    Ignored:    data/Ind3_TSS_peaks.RDS
    Ignored:    data/Ind3_fragment_files.txt
    Ignored:    data/Ind3_peaks_list.RDS
    Ignored:    data/Ind3_summary.txt
    Ignored:    data/Ind4_79B24h_dedup_peaks.csv
    Ignored:    data/Ind4_TSS_peaks.RDS
    Ignored:    data/Ind4_V24h_fraglength.txt
    Ignored:    data/Ind4_fragment_files.txt
    Ignored:    data/Ind4_fragment_filesN.txt
    Ignored:    data/Ind4_peaks_list.RDS
    Ignored:    data/Ind4_summary.txt
    Ignored:    data/Ind5_TSS_peaks.RDS
    Ignored:    data/Ind5_fragment_files.txt
    Ignored:    data/Ind5_fragment_filesN.txt
    Ignored:    data/Ind5_peaks_list.RDS
    Ignored:    data/Ind5_summary.txt
    Ignored:    data/Ind6_TSS_peaks.RDS
    Ignored:    data/Ind6_fragment_files.txt
    Ignored:    data/Ind6_peaks_list.RDS
    Ignored:    data/Ind6_summary.txt
    Ignored:    data/Knowles_4.RDS
    Ignored:    data/Knowles_5.RDS
    Ignored:    data/Knowles_6.RDS
    Ignored:    data/LiSiLTDNRe_TE_df.RDS
    Ignored:    data/MI_gwas.RDS
    Ignored:    data/SNP_GWAS_PEAK_MRC_id
    Ignored:    data/SNP_GWAS_PEAK_MRC_id.csv
    Ignored:    data/SNP_gene_cat_list.tsv
    Ignored:    data/SNP_supp_schneider.RDS
    Ignored:    data/TE_info/
    Ignored:    data/TFmapnames.RDS
    Ignored:    data/all_TSSE_scores.RDS
    Ignored:    data/all_four_filtered_counts.txt
    Ignored:    data/aln_run1_results.txt
    Ignored:    data/anno_ind1_DA24h.RDS
    Ignored:    data/anno_ind4_V24h.RDS
    Ignored:    data/annotated_gwas_SNPS.csv
    Ignored:    data/background_n45_he_peaks.RDS
    Ignored:    data/cardiac_muscle_FRIP.csv
    Ignored:    data/cardiomyocyte_FRIP.csv
    Ignored:    data/col_ng_peak.csv
    Ignored:    data/cormotif_full_4_run.RDS
    Ignored:    data/cormotif_full_4_run_he.RDS
    Ignored:    data/cormotif_full_6_run.RDS
    Ignored:    data/cormotif_full_6_run_he.RDS
    Ignored:    data/cormotif_probability_45_list.csv
    Ignored:    data/cormotif_probability_45_list_he.csv
    Ignored:    data/cormotif_probability_all_6_list.csv
    Ignored:    data/cormotif_probability_all_6_list_he.csv
    Ignored:    data/datasave.RDS
    Ignored:    data/embryo_heart_FRIP.csv
    Ignored:    data/enhancer_list_ENCFF126UHK.bed
    Ignored:    data/enhancerdata/
    Ignored:    data/filt_Peaks_efit2.RDS
    Ignored:    data/filt_Peaks_efit2_bl.RDS
    Ignored:    data/filt_Peaks_efit2_n45.RDS
    Ignored:    data/first_Peaksummarycounts.csv
    Ignored:    data/first_run_frag_counts.txt
    Ignored:    data/full_bedfiles/
    Ignored:    data/gene_ref.csv
    Ignored:    data/gwas_1_dataframe.RDS
    Ignored:    data/gwas_2_dataframe.RDS
    Ignored:    data/gwas_3_dataframe.RDS
    Ignored:    data/gwas_4_dataframe.RDS
    Ignored:    data/gwas_5_dataframe.RDS
    Ignored:    data/high_conf_peak_counts.csv
    Ignored:    data/high_conf_peak_counts.txt
    Ignored:    data/high_conf_peaks_bl_counts.txt
    Ignored:    data/high_conf_peaks_counts.txt
    Ignored:    data/hits_files/
    Ignored:    data/hyper_files/
    Ignored:    data/hypo_files/
    Ignored:    data/ind1_DA24hpeaks.RDS
    Ignored:    data/ind1_TSSE.RDS
    Ignored:    data/ind2_TSSE.RDS
    Ignored:    data/ind3_TSSE.RDS
    Ignored:    data/ind4_TSSE.RDS
    Ignored:    data/ind4_V24hpeaks.RDS
    Ignored:    data/ind5_TSSE.RDS
    Ignored:    data/ind6_TSSE.RDS
    Ignored:    data/initial_complete_stats_run1.txt
    Ignored:    data/left_ventricle_FRIP.csv
    Ignored:    data/median_24_lfc.RDS
    Ignored:    data/median_3_lfc.RDS
    Ignored:    data/mergedPeads.gff
    Ignored:    data/mergedPeaks.gff
    Ignored:    data/motif_list_full
    Ignored:    data/motif_list_n45
    Ignored:    data/motif_list_n45.RDS
    Ignored:    data/multiqc_fastqc_run1.txt
    Ignored:    data/multiqc_fastqc_run2.txt
    Ignored:    data/multiqc_genestat_run1.txt
    Ignored:    data/multiqc_genestat_run2.txt
    Ignored:    data/my_hc_filt_counts.RDS
    Ignored:    data/my_hc_filt_counts_n45.RDS
    Ignored:    data/n45_bedfiles/
    Ignored:    data/n45_files
    Ignored:    data/other_papers/
    Ignored:    data/peakAnnoList_1.RDS
    Ignored:    data/peakAnnoList_2.RDS
    Ignored:    data/peakAnnoList_24_full.RDS
    Ignored:    data/peakAnnoList_24_n45.RDS
    Ignored:    data/peakAnnoList_3.RDS
    Ignored:    data/peakAnnoList_3_full.RDS
    Ignored:    data/peakAnnoList_3_n45.RDS
    Ignored:    data/peakAnnoList_4.RDS
    Ignored:    data/peakAnnoList_5.RDS
    Ignored:    data/peakAnnoList_6.RDS
    Ignored:    data/peakAnnoList_Eight.RDS
    Ignored:    data/peakAnnoList_full_motif.RDS
    Ignored:    data/peakAnnoList_n45_motif.RDS
    Ignored:    data/siglist_full.RDS
    Ignored:    data/siglist_n45.RDS
    Ignored:    data/summarized_peaks_dataframe.txt
    Ignored:    data/summary_peakIDandReHeat.csv
    Ignored:    data/test.list.RDS
    Ignored:    data/testnames.txt
    Ignored:    data/toplist_6.RDS
    Ignored:    data/toplist_full.RDS
    Ignored:    data/toplist_full_DAR_6.RDS
    Ignored:    data/toplist_n45.RDS
    Ignored:    data/trimmed_seq_length.csv
    Ignored:    data/unclassified_full_set_peaks.RDS
    Ignored:    data/unclassified_n45_set_peaks.RDS
    Ignored:    data/xstreme/

Untracked files:
    Untracked:  analysis/Diagnosis-tmm.Rmd
    Untracked:  analysis/Expressed_RNA_associations.Rmd
    Untracked:  analysis/LFC_corr.Rmd
    Untracked:  analysis/SVA.Rmd
    Untracked:  analysis/Tan2020.Rmd
    Untracked:  analysis/making_master_peaks_list.Rmd
    Untracked:  analysis/my_hc_filt_counts.csv
    Untracked:  code/IGV_snapshot_code.R
    Untracked:  code/LongDARlist.R
    Untracked:  code/just_for_Fun.R
    Untracked:  output/cormotif_probability_45_list.csv
    Untracked:  output/cormotif_probability_all_6_list.csv
    Untracked:  setup.RData

Unstaged changes:
    Modified:   ATAC_learning.Rproj
    Modified:   analysis/Jaspar_motif.Rmd
    Modified:   analysis/Jaspar_motif_ff.Rmd
    Modified:   analysis/final_four_analysis.Rmd
    Modified:   analysis/index.Rmd

Note that any generated files, e.g. HTML, png, CSS, etc., are not included in this status report because it is ok for generated content to have uncommitted changes.

These are the previous versions of the repository in which changes were made to the R Markdown (analysis/Jaspar_motif_norm.Rmd) and HTML (docs/Jaspar_motif_norm.html) files. If you’ve configured a remote Git repository (see ?wflow_git_remote), click on the hyperlinks in the table below to view the files as they were in that past version.

File Version Author Date Message
Rmd 0fb8e8b reneeisnowhere 2025-05-08 updates to analysis 
library(tidyverse)
library(cowplot)
library(kableExtra)
library(broom)
library(RColorBrewer)
library(ChIPseeker)
library("TxDb.Hsapiens.UCSC.hg38.knownGene")
library("org.Hs.eg.db")
library(rtracklayer)
library(edgeR)
library(ggfortify)
library(limma)
library(readr)
library(BiocGenerics)
library(gridExtra)
library(VennDiagram)
library(scales)
library(Cormotif)
library(BiocParallel)
library(ggpubr)
library(devtools)
library(JASPAR2022)
library(TFBSTools)
library(MotifDb)
library(BSgenome.Hsapiens.UCSC.hg38)
library(data.table)
library(universalmotif)
library(ggseqlogo)
library(motifmatchr)
library(gridExtra)
mrc_palette <- c(
    "EAR_open" = "#F8766D",
    "EAR_close" = "#f6483c",
    "ESR_open" = "#7CAE00",
    "ESR_close" = "#587b00",
    "ESR_C"="grey40",
     "ESR_opcl"="grey40",
    "ESR_D"="tan",
     "ESR_clop"="tan",
     "LR_open" = "#00BFC4",
     "LR_close" = "#008d91",
     "NR" = "#C77CFF"
  )

EAR_open data EAR_open

EAR_open_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_open_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
EAR_open_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_open_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
EAR_open_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_open_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
EAR_open_sea_all <- rbind(EAR_open_sea_disc, EAR_open_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)
EAR_open_combo <- EAR_open_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., EAR_open_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ NA_character_
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="EAR_open")

EAR_open_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")
Enriched motifs 200 bp in EAR open v NR
RANK CLUSTER SIM_MOTIF ALT_ID ID CONSENSUS.x motif_name EVALUE.y QVALUE TP TP. FP FP. ENR_RATIO mrc_type
1 1 MA1721.1 (ZNF93) MEME-3 CGSSSSSSGCSSSGS CGSSSSSSGCSSSGS ZNF93 1.2e-28 9.74e-29 1270 28.8 16200 21.2 1.36 EAR_open
2 2 MA1650.1 ZBTB14 MA1650.1 SSCCGCGCACVS ZBTB14 4.64e-27 1.89e-27 1480 33.4 19600 25.6 1.31 EAR_open
3 3 2-GCGSCGC STREME-2 2-GCGSCGC GCGSCGC GCGSCGC 2.15e-26 5.82e-27 1760 39.8 24200 31.6 1.26 EAR_open
4 4 4-GCGGCC STREME-4 4-GCGGCC GCGGCC GCGGCC 1.7e-24 3.46e-25 1560 35.4 21200 27.7 1.28 EAR_open
5 7 MA1713.1 ZNF610 MA1713.1 SSCGCCGCTCCSSS ZNF610 5.74e-24 9.32e-25 1220 27.7 15900 20.8 1.34 EAR_open
6 5 MA0506.2 Nrf1 MA0506.2 SNCTGCGCMTGCGCV Nrf1 1.77e-23 2.4e-24 880 20 10700 14 1.43 EAR_open
7 6 5-CCCGGAG STREME-5 5-CCCGGAG CCCGGAG CCCGGAG 5.54e-23 5.85e-24 1060 24 13400 17.5 1.37 EAR_open
8 7 MA1713.1 (ZNF610) STREME-6 6-CGCTCC CGCTCC ZNF610 5.76e-23 5.85e-24 1360 30.9 18200 23.7 1.3 EAR_open
9 8 1-SCGGNCCGS STREME-1 1-SCGGNCCGS SCGGNCCGS SCGGNCCGS 2.47e-20 2.23e-21 837 19 10300 13.5 1.41 EAR_open
10 9 MA0506.2 (Nrf1) STREME-8 8-GCAGGCGC GCAGGCGC Nrf1 4.95e-20 4.02e-21 1750 39.8 24900 32.5 1.22 EAR_open
11 10 MA0162.4 EGR1 MA0162.4 VCMCGCCCACGCVS EGR1 3.7e-19 2.73e-20 1290 29.2 17400 22.8 1.28 EAR_open
12 11 3-CCGGAGC STREME-3 3-CCGGAGC CCGGAGC CCGGAGC 6.82e-19 4.62e-20 1580 35.9 22300 29.1 1.24 EAR_open
13 12 MA1122.1 TFDP1 MA1122.1 VSGCGGGAAVN TFDP1 9.22e-18 5.76e-19 1270 28.7 17300 22.5 1.28 EAR_open
14 13 MA1990.1 (Gli1) STREME-9 9-ACACACCACACACAC ACACACCACACACAC Gli1 3.81e-17 2.14e-18 65 1.47 257 0.34 4.44 EAR_open
15 1 MA1721.1 (ZNF93) MEME-5 GGMGGSGGSGGCSGS GGMGGSGGSGGCSGS ZNF93 3.96e-17 2.14e-18 702 15.9 8590 11.2 1.42 EAR_open
16 14 MA1513.1 KLF15 MA1513.1 SCCCCGCCCCS KLF15 6.01e-16 3.05e-17 1360 30.7 18900 24.7 1.25 EAR_open
17 10 MA0472.2 EGR2 MA0472.2 MCGCCCACGCA EGR2 8.37e-15 4e-16 1700 38.5 24700 32.2 1.19 EAR_open
18 15 MA1106.1 HIF1A MA1106.1 SBACGTGCNN HIF1A 9.74e-15 4.4e-16 2180 49.3 32800 42.8 1.15 EAR_open
19 15 MA0632.2 TCFL5 MA0632.2 KCACGCGCMC TCFL5 1.59e-14 6.81e-16 1320 29.8 18500 24.1 1.24 EAR_open
20 12 MA1583.1 ZFP57 MA1583.1 NNVTTGCCGCANN ZFP57 1.49e-13 6.05e-15 774 17.6 10000 13.1 1.34 EAR_open
21 16 MA0131.2 HINFP MA0131.2 CARCGTCCGCKN HINFP 2.07e-13 8.02e-15 853 19.3 11300 14.7 1.32 EAR_open
22 17 MA0814.2 TFAP2C MA0814.2 NNGCCTGAGGCGNN TFAP2C 3.2e-13 1.18e-14 1780 40.4 26300 34.4 1.18 EAR_open
23 18 MA0527.1 ZBTB33 MA0527.1 BTCTCGCGAGABYTS ZBTB33 7.97e-13 2.81e-14 808 18.3 10600 13.9 1.32 EAR_open
24 19 MA0748.2 YY2 MA0748.2 NVATGGCGGCS YY2 2.36e-12 8.01e-14 707 16 9130 11.9 1.35 EAR_open
25 20 MA1971.1 ZBED2 MA1971.1 NNMMCGAAACCNNV ZBED2 8.97e-10 2.92e-11 771 17.5 10400 13.6 1.29 EAR_open
26 15 MA0821.2 HES5 MA0821.2 GRCACGTGYC HES5 2.17e-09 6.78e-11 1550 35.1 23100 30.1 1.17 EAR_open
27 21 MA0146.2 Zfx MA0146.2 SSSGCCBVGGCCTS Zfx 5.12e-09 1.5e-10 1250 28.4 18300 23.8 1.19 EAR_open
28 22 MA0024.3 E2F1 MA0024.3 TTTGGCGCCAAA E2F1 5.16e-09 1.5e-10 715 16.2 9640 12.6 1.29 EAR_open
29 23 MA0014.3 PAX5 MA0014.3 RRGCGTGACCNN PAX5 1.36e-08 3.81e-10 1170 26.5 16900 22.1 1.2 EAR_open
30 24 MA1684.1 Foxn1 MA1684.1 RGAMGC Foxn1 9.21e-08 2.49e-09 429 9.73 5410 7.06 1.38 EAR_open
31 15 MA0259.1 ARNT::HIF1A MA0259.1 VBACGTGC ARNT::HIF1A 1.95e-07 5.1e-09 1970 44.8 30600 40 1.12 EAR_open
32 25 MA1721.1 ZNF93 MA1721.1 GGYAGCRGCAGCGGYG ZNF93 2.76e-07 6.79e-09 1760 39.9 27100 35.3 1.13 EAR_open
33 13 MA1107.2 (KLF9) STREME-7 7-CATGCACACACACA CATGCACACACACA KLF9 2.76e-07 6.79e-09 62 1.41 417 0.54 2.62 EAR_open
34 15 MA1099.2 HES1 MA1099.2 GGCRCGTGBC HES1 3.55e-07 8.49e-09 977 22.2 14100 18.4 1.21 EAR_open
35 15 MA0823.1 HEY1 MA0823.1 GRCACGTGCC HEY1 1.16e-06 2.69e-08 1520 34.6 23200 30.3 1.14 EAR_open
36 26 MA0810.1 TFAP2A MA0810.1 YGCCCBVRGGCR TFAP2A 1.39e-06 3.13e-08 1540 34.8 23400 30.6 1.14 EAR_open
37 27 MA0695.1 ZBTB7C MA0695.1 RCGACCACCGAN ZBTB7C 1.99e-06 4.36e-08 722 16.4 10100 13.2 1.24 EAR_open
38 28 MA1985.1 ZNF669 MA1985.1 GGGGYGAYGACCRCT ZNF669 2.13e-06 4.55e-08 1370 31 20600 26.9 1.15 EAR_open
39 10 MA0733.1 EGR4 MA0733.1 NHMCGCCCACGCAHWT EGR4 2.97e-06 6.18e-08 675 15.3 9390 12.2 1.25 EAR_open
40 13 MA1107.2 (KLF9) MEME-4 ACAYRCACACACACA ACAYRCACACACACA KLF9 3.22e-06 6.55e-08 291 6.6 3520 4.59 1.44 EAR_open
41 15 MA1560.1 SOHLH2 MA1560.1 YGCACGTGCN SOHLH2 4.43e-06 8.79e-08 1340 30.4 20200 26.4 1.15 EAR_open
42 29 MA1986.1 ZNF692 MA1986.1 BGGGCCCASN ZNF692 9.57e-06 1.85e-07 1300 29.4 19600 25.5 1.15 EAR_open
43 13 MA0734.3 Gli2 MA0734.3 NRGACCACCCASV Gli2 1.85e-05 3.49e-07 1800 40.7 28000 36.6 1.11 EAR_open
44 30 MA1976.1 ZNF320 MA1976.1 DGKGGGRCCMRGGGGCCWGTGHVNNNN ZNF320 1.98e-05 3.66e-07 1060 24 15700 20.5 1.17 EAR_open
45 12 MA0471.2 E2F6 MA0471.2 VVDGGCGGGAAVV E2F6 2.51e-05 4.53e-07 1720 39.1 26900 35 1.12 EAR_open
46 17 MA1569.1 TFAP2E MA1569.1 YGCCYSRGGCD TFAP2E 4.07e-05 7.19e-07 776 17.6 11200 14.6 1.21 EAR_open
47 15 MA0616.2 HES2 MA0616.2 GGCACGTGYC HES2 5.06e-05 8.74e-07 1800 40.8 28200 36.8 1.11 EAR_open
48 23 MA0067.2 PAX2 MA0067.2 BCAVTSRAGCGTGACGR PAX2 6.65e-05 1.13e-06 1090 24.6 16300 21.2 1.16 EAR_open
49 31 MA1712.1 ZNF454 MA1712.1 DGGCTCSSGGCCCYGVKG ZNF454 7.58e-05 1.26e-06 278 6.3 3460 4.51 1.4 EAR_open
50 15 MA0830.2 TCF4 MA0830.2 NNGCACCTGCCNN TCF4 0.000128 2.08e-06 1800 40.8 28300 37 1.1 EAR_open
51 32 MA0759.2 ELK3 MA0759.2 ACCGGAAGTRV ELK3 0.000186 2.96e-06 955 21.7 14200 18.5 1.17 EAR_open
52 26 MA0872.1 TFAP2A MA0872.1 TGCCCYSRGGGCA TFAP2A 0.00026 4.07e-06 1060 24.1 16000 20.9 1.15 EAR_open
53 12 MA0865.2 E2F8 MA0865.2 TTCCCGCCAHWA E2F8 0.000268 4.11e-06 528 12 7360 9.61 1.25 EAR_open
54 33 MA1941.1 ETV2::FIGLA MA1941.1 RSCGGAARCAGSTGBN ETV2::FIGLA 0.000278 4.18e-06 798 18.1 11700 15.2 1.19 EAR_open
55 13 MA1990.1 Gli1 MA1990.1 NNRGACCACCCASV Gli1 0.000338 5e-06 1140 25.9 17400 22.7 1.14 EAR_open
56 34 MA1719.1 ZNF816 MA1719.1 DRRKGGGGACATGCHGGG ZNF816 0.000405 5.88e-06 1460 33 22600 29.5 1.12 EAR_open
57 15 MA0147.3 MYC MA0147.3 NNCCACGTGCNB MYC 0.000543 7.73e-06 3020 68.4 49700 64.8 1.06 EAR_open
58 10 MA1515.1 KLF2 MA1515.1 NRCCACRCCCH KLF2 0.000603 8.45e-06 1910 43.3 30400 39.6 1.09 EAR_open
59 35 MA1533.1 NR1I2 MA1533.1 DYGAACTSVDTGAACTC NR1I2 0.000832 1.15e-05 1300 29.5 20100 26.2 1.13 EAR_open
60 22 MA0470.2 E2F4 MA0470.2 TTTTGGCGCCAWWW E2F4 0.000909 1.23e-05 543 12.3 7680 10 1.23 EAR_open
61 36 MA1602.1 ZSCAN29 MA1602.1 YGTCTACRCNGN ZSCAN29 0.000933 1.24e-05 1080 24.6 16500 21.5 1.14 EAR_open
62 22 MA1727.1 ZNF417 MA1727.1 VRBVNTGGGCGCCAM ZNF417 0.000957 1.25e-05 1470 33.4 23000 30 1.11 EAR_open
63 15 MA0006.1 Ahr::Arnt MA0006.1 YGCGTG Ahr::Arnt 0.000995 1.27e-05 725 16.4 10600 13.8 1.19 EAR_open
64 10 MA0732.1 EGR3 MA0732.1 HHMCGCCCACGCAHH EGR3 0.001 1.27e-05 628 14.2 9040 11.8 1.21 EAR_open
65 15 MA0615.1 Gmeb1 MA0615.1 BHBBKKACGTMMNWNNN Gmeb1 0.00104 1.3e-05 372 8.44 5010 6.54 1.29 EAR_open
66 10 MA1517.1 KLF6 MA1517.1 NRCCACGCCCH KLF6 0.00111 1.36e-05 1850 41.9 29400 38.4 1.09 EAR_open
67 17 MA0003.4 TFAP2A MA0003.4 NNKGCCTCAGGCNN TFAP2A 0.0013 1.57e-05 832 18.9 12400 16.1 1.17 EAR_open
68 17 MA0812.1 TFAP2B MA0812.1 HGCCTSAGGCD TFAP2B 0.00149 1.78e-05 1690 38.4 26800 34.9 1.1 EAR_open
69 26 MA0524.2 TFAP2C MA0524.2 YGCCYBVRGGCA TFAP2C 0.0017 2e-05 1780 40.3 28200 36.9 1.09 EAR_open
70 37 MA1102.2 CTCFL MA1102.2 NSCAGGGGGCGS CTCFL 0.00214 2.48e-05 1730 39.2 27400 35.8 1.1 EAR_open
13 13 MA1107.2 (KLF9) MEME-1 ACACACABRCACACA ACACACABRCACACA KLF9 0.00226 0.000174 68 1.54 723 0.94 1.66 EAR_open
71 38 MA1596.1 ZNF460 MA1596.1 GCCTCMGCCTCCCRAG ZNF460 0.00288 3.3e-05 1180 26.7 18200 23.7 1.13 EAR_open
72 26 MA0811.1 TFAP2B MA0811.1 YGCCCBVRGGCA TFAP2B 0.00339 3.83e-05 1750 39.8 27900 36.4 1.09 EAR_open
73 22 MA0864.2 E2F2 MA0864.2 RWTTTGGCGCCAWWWY E2F2 0.00453 5.05e-05 450 10.2 6320 8.25 1.24 EAR_open
74 39 MA0736.1 GLIS2 MA0736.1 GACCCCCCGCRAMG GLIS2 0.00499 5.48e-05 933 21.2 14200 18.5 1.15 EAR_open
75 15 MA0649.1 HEY2 MA0649.1 GRCACGTGYC HEY2 0.00567 6.15e-05 664 15.1 9760 12.7 1.18 EAR_open
76 15 MA1464.1 ARNT2 MA1464.1 GTCACGTGMN ARNT2 0.00604 6.45e-05 1770 40 28200 36.8 1.09 EAR_open
77 29 MA1548.1 PLAGL2 MA1548.1 NGGGCCCCCN PLAGL2 0.00789 8.33e-05 1620 36.7 25700 33.5 1.09 EAR_open
78 32 MA0645.1 ETV6 MA0645.1 MSCGGAAGTR ETV6 0.00855 8.82e-05 59 1.34 540 0.7 1.93 EAR_open
79 26 MA0815.1 TFAP2C MA0815.1 TGCCCYSRGGGCA TFAP2C 0.00867 8.82e-05 1040 23.5 15900 20.7 1.13 EAR_open
80 40 MA1964.1 SMAD2 MA1964.1 NBCCAGACDN SMAD2 0.00868 8.82e-05 1950 44.2 31300 40.9 1.08 EAR_open
81 15 MA0104.4 MYCN MA0104.4 VVCCACGTGGBB MYCN 0.0143 0.000144 2380 53.8 38800 50.6 1.06 EAR_open
82 13 MA1514.1 KLF17 MA1514.1 MMCCACGCACCCMTY KLF17 0.0149 0.000148 2250 51.1 36700 47.8 1.07 EAR_open
83 27 MA0694.1 ZBTB7B MA0694.1 RCGACCACCGAA ZBTB7B 0.0188 0.000184 335 7.6 4620 6.02 1.26 EAR_open
84 26 MA0813.1 TFAP2B MA0813.1 TGCCCYBRGGGCA TFAP2B 0.02 0.000193 1010 22.8 15500 20.2 1.13 EAR_open
85 41 MA1981.1 ZNF530 MA1981.1 GMARGGMRAGGGGCRGSV ZNF530 0.0214 0.000204 1690 38.2 27000 35.2 1.09 EAR_open
14 42 MA1125.1 (ZNF384) MEME-2 TTTTTWTTTTTTTTT TTTTTWTTTTTTTTT ZNF384 14 1 127 2.88 2960 3.87 0.75 EAR_open 
ER_rat <- 1.25
mrc_type <- "EAR_open"
EAR_open_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

EAR_open_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*.5), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.5,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

EAR_close data

EAR_close_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_close_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
EAR_close_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_close_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
EAR_close_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_close_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
EAR_close_sea_all <- rbind(EAR_close_sea_disc, EAR_close_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)
EAR_close_combo <- EAR_close_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., EAR_close_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="EAR_close")

EAR_close_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")
Enriched motifs 200 bp in EAR open v NR
RANK CLUSTER SIM_MOTIF ALT_ID ID CONSENSUS.x motif_name EVALUE.y QVALUE TP TP. FP FP. ENR_RATIO mrc_type
1 1 MA0476.1 (FOS) STREME-1 1-VTGASTCAB VTGASTCAB FOS 4.82e-72 2.63e-72 1200 43.5 20700 27 1.61 EAR_close
2 1 MA1633.2 BACH1 MA1633.2 ATGACTCAT BACH1 8.33e-71 2.28e-71 1120 40.3 18700 24.3 1.66 EAR_close
3 1 MA0489.2 Jun MA0489.2 NVTGACTCATNN Jun 3.77e-65 6.86e-66 1100 39.6 18600 24.3 1.63 EAR_close
4 1 MA0462.2 BATF::JUN MA0462.2 DATGACTCATH BATF::JUN 5.26e-65 7.19e-66 1120 40.6 19300 25.2 1.61 EAR_close
5 1 MA1130.1 FOSL2::JUN MA1130.1 NNRTGAGTCAYN FOSL2::JUN 8.59e-64 9.39e-65 1090 39.3 18600 24.2 1.62 EAR_close
6 1 MA0477.2 FOSL1 MA0477.2 NNATGACTCATNN FOSL1 1.15e-63 1.05e-64 1370 49.4 25400 33.2 1.49 EAR_close
7 1 MA1988.1 Atf3 MA1988.1 NRTGACTCABN Atf3 2.53e-63 1.98e-64 1190 43 21000 27.5 1.57 EAR_close
8 1 MA0490.2 JUNB MA0490.2 NNATGACTCATNN JUNB 6.88e-63 4.7e-64 1220 44 21800 28.4 1.55 EAR_close
9 1 MA1134.1 FOS::JUNB MA1134.1 KATGASTCATHN FOS::JUNB 9.64e-63 5.85e-64 918 33.2 14700 19.1 1.73 EAR_close
10 1 MA1144.1 FOSL2::JUND MA1144.1 KATGACTCAT FOSL2::JUND 1.96e-62 1.07e-63 1040 37.4 17400 22.7 1.65 EAR_close
11 1 MA1135.1 FOSB::JUNB MA1135.1 KRTGASTCAT FOSB::JUNB 3.21e-62 1.6e-63 1380 49.7 25800 33.7 1.48 EAR_close
12 1 MA1141.1 FOS::JUND MA1141.1 NKATGAGTCATNN FOS::JUND 5.57e-62 2.54e-63 893 32.3 14200 18.5 1.75 EAR_close
13 1 MA1138.1 FOSL2::JUNB MA1138.1 KRTGASTCAT FOSL2::JUNB 1.38e-61 5.82e-63 941 34 15300 19.9 1.71 EAR_close
14 2 MA0036.3 (GATA2) STREME-2 2-GWGATAA GWGATAA GATA2 6.53e-61 2.55e-62 1970 71.1 42300 55.2 1.29 EAR_close
15 3 MA0498.2 (MEIS1) STREME-3 3-CTGTCAG CTGTCAG MEIS1 8.83e-60 3.22e-61 2680 96.8 67300 87.8 1.1 EAR_close
16 1 MA0476.1 FOS MA0476.1 DVTGASTCATB FOS 4.03e-59 1.38e-60 848 30.6 13400 17.4 1.76 EAR_close
17 1 MA0491.2 JUND MA0491.2 NNATGACTCATNN JUND 9.69e-59 3.11e-60 879 31.8 14100 18.4 1.73 EAR_close
18 1 MA1988.1 (Atf3) MEME-1 TGACTCAB TGACTCAB Atf3 1.19e-58 3.61e-60 753 27.2 11300 14.8 1.85 EAR_close
19 1 MA1634.1 BATF MA1634.1 DATGACTCATH BATF 2.73e-58 7.85e-60 1220 43.9 22100 28.9 1.52 EAR_close
20 1 MA0835.2 BATF3 MA0835.2 DATGACTCATH BATF3 2.62e-55 7.15e-57 1460 52.6 28500 37.2 1.41 EAR_close
21 1 MA0655.1 JDP2 MA0655.1 ATGACTCAT JDP2 9.11e-55 2.37e-56 986 35.6 16900 22 1.62 EAR_close
22 1 MA1132.1 JUN::JUNB MA1132.1 KATGACKCAT JUN::JUNB 1.14e-53 2.82e-55 1450 52.3 28500 37.2 1.41 EAR_close
23 1 MA1128.1 FOSL1::JUN MA1128.1 NKATGACTCATNN FOSL1::JUN 1.25e-53 2.97e-55 1660 59.9 34200 44.7 1.34 EAR_close
24 1 MA0099.3 FOS::JUN MA0099.3 ATGAGTCAYM FOS::JUN 1.7e-53 3.87e-55 756 27.3 11700 15.3 1.79 EAR_close
25 1 MA1928.1 BNC2 MA1928.1 NDRTGAGTCABN BNC2 3.38e-53 7.38e-55 1410 50.9 27500 35.9 1.42 EAR_close
26 1 MA1142.1 FOSL1::JUND MA1142.1 NRTGACTCAT FOSL1::JUND 4.41e-53 9.27e-55 1300 47 24800 32.3 1.46 EAR_close
27 1 MA1137.1 FOSL1::JUNB MA1137.1 NDRTGACTCATNN FOSL1::JUNB 6.94e-52 1.4e-53 868 31.4 14400 18.7 1.67 EAR_close
28 1 MA0478.1 FOSL2 MA0478.1 KRRTGASTCAB FOSL2 2.95e-49 5.75e-51 714 25.8 11100 14.5 1.78 EAR_close
29 1 MA0150.2 Nfe2l2 MA0150.2 CASNATGACTCAGCA Nfe2l2 5.3e-44 9.99e-46 1700 61.3 36300 47.4 1.29 EAR_close
30 1 MA1101.2 BACH2 MA1101.2 DWANCATGASTCATSNTWH BACH2 8.22e-44 1.5e-45 695 25.1 11100 14.5 1.73 EAR_close
31 4 MA0084.1 SRY MA0084.1 NWWAACAAT SRY 2.89e-42 5.1e-44 2650 95.8 67500 88.1 1.09 EAR_close
32 2 MA0766.2 GATA5 MA0766.2 SWGATAASRN GATA5 5.92e-41 1.01e-42 1020 37 19100 24.9 1.49 EAR_close
33 5 MA0676.1 Nr2e1 MA0676.1 AAAAGTCAA Nr2e1 8.35e-41 1.38e-42 2400 86.9 58400 76.2 1.14 EAR_close
34 1 MA0841.1 NFE2 MA0841.1 VATGACTCATS NFE2 1.65e-40 2.65e-42 674 24.4 10900 14.2 1.71 EAR_close
35 1 MA0496.3 MAFK MA0496.3 NGMTGACTCAGCMNH MAFK 4.46e-37 6.96e-39 894 32.3 16300 21.3 1.52 EAR_close
36 1 MA0089.2 MAFG::NFE2L1 MA0089.2 NVNATGACTCAGCADW MAFG::NFE2L1 4.96e-37 7.53e-39 940 34 17400 22.7 1.5 EAR_close
37 6 5-AASATA STREME-5 5-AASATA AASATA AASATA 8.84e-32 1.31e-33 2470 89.3 61800 80.6 1.11 EAR_close
38 1 MA0501.1 MAF::NFE2 MA0501.1 ATGACTCAGCANWTY MAF::NFE2 2.38e-31 3.42e-33 700 25.3 12300 16 1.58 EAR_close
39 2 MA0036.3 GATA2 MA0036.3 NBCTTATCTNH GATA2 1.82e-28 2.55e-30 639 23.1 11200 14.6 1.58 EAR_close
40 7 MA1640.1 MEIS2 MA1640.1 NNATGATTTATGDNH MEIS2 7.65e-28 1.04e-29 2470 89.3 62300 81.2 1.1 EAR_close
41 8 MA0725.1 VSX1 MA0725.1 YTAATTAN VSX1 9.08e-28 1.21e-29 2640 95.3 68300 89.1 1.07 EAR_close
42 2 MA1104.2 GATA6 MA1104.2 HWWTCTTATCTNH GATA6 1.03e-26 1.34e-28 555 20 9440 12.3 1.63 EAR_close
43 3 MA0774.1 MEIS2 MA0774.1 TTGACAGS MEIS2 1.58e-26 2.01e-28 698 25.2 12700 16.6 1.52 EAR_close
44 8 MA0707.2 MNX1 MA0707.2 VYRATTAK MNX1 1.9e-26 2.36e-28 1770 63.9 40700 53.1 1.2 EAR_close
45 2 MA0037.4 Gata3 MA0037.4 NHTCTTATCTNH Gata3 6.52e-26 7.92e-28 445 16.1 7090 9.25 1.74 EAR_close
46 8 MA0027.2 EN1 MA0027.2 SYAATTAV EN1 1.36e-25 1.61e-27 2490 89.9 63100 82.3 1.09 EAR_close
47 7 MA1639.1 MEIS1 MA1639.1 NHCATMAATCAHN MEIS1 4.05e-25 4.7e-27 2150 77.6 52100 68 1.14 EAR_close
48 8 MA1476.2 Dlx5 MA1476.2 NDGCAATTAGNN Dlx5 5.47e-25 6.22e-27 2500 90.5 63700 83.1 1.09 EAR_close
49 3 MA0498.2 MEIS1 MA0498.2 HTGACAD MEIS1 4.23e-24 4.72e-26 1240 44.9 26700 34.8 1.29 EAR_close
50 8 MA0726.1 VSX2 MA0726.1 CTAATTAN VSX2 2.75e-23 3e-25 2480 89.4 62900 82.1 1.09 EAR_close
51 4 MA1152.1 SOX15 MA1152.1 CYWTTGTTHW SOX15 3.04e-23 3.26e-25 2680 96.6 70200 91.6 1.05 EAR_close
52 9 MA0845.1 FOXB1 MA0845.1 WATGTAAATAT FOXB1 3.25e-23 3.41e-25 2420 87.2 60900 79.5 1.1 EAR_close
53 8 MA0644.2 ESX1 MA0644.2 YYAATTAN ESX1 6.27e-23 6.46e-25 2320 83.7 57700 75.3 1.11 EAR_close
54 8 MA0716.1 PRRX1 MA0716.1 YYAATTAR PRRX1 9.77e-23 9.89e-25 2420 87.4 61100 79.7 1.1 EAR_close
55 10 MA1645.1 (NKX2-2) STREME-7 7-ACTCAA ACTCAA NKX2-2 2.27e-22 2.25e-24 919 33.2 18600 24.3 1.37 EAR_close
56 8 MA0675.1 NKX6-2 MA0675.1 NYMATTAA NKX6-2 2.55e-22 2.48e-24 2340 84.4 58500 76.3 1.11 EAR_close
57 8 MA0674.1 NKX6-1 MA0674.1 NTMATTAA NKX6-1 2.9e-22 2.78e-24 2140 77.3 52300 68.3 1.13 EAR_close
58 11 MA0792.1 POU5F1B MA0792.1 TATGCWAAT POU5F1B 4.28e-22 4.03e-24 2590 93.4 66900 87.4 1.07 EAR_close
59 2 MA1970.1 TRPS1 MA1970.1 NHTCTTATCTNH TRPS1 4.47e-21 4.14e-23 333 12 5100 6.65 1.81 EAR_close
60 12 MA0769.2 TCF7 MA0769.2 NNCTTTGAWVT TCF7 6.03e-21 5.49e-23 2690 97.3 71200 93 1.05 EAR_close
61 2 MA0482.2 GATA4 MA0482.2 NNCCTTATCTNH GATA4 1.21e-20 1.09e-22 523 18.9 9310 12.2 1.56 EAR_close
62 8 MA0721.1 UNCX MA0721.1 YYAATTAV UNCX 1.32e-20 1.17e-22 2490 90 63800 83.3 1.08 EAR_close
63 7 MA1113.2 PBX2 MA1113.2 NHCATAAATCAHN PBX2 1.8e-20 1.56e-22 2140 77.2 52600 68.6 1.13 EAR_close
64 8 MA0634.1 ALX3 MA0634.1 YYYAATTANV ALX3 2.98e-20 2.55e-22 2560 92.5 66300 86.5 1.07 EAR_close
65 13 MA1963.1 SATB1 MA1963.1 WWDCTAATAAHWW SATB1 2.86e-19 2.4e-21 2120 76.5 52100 68 1.12 EAR_close
66 8 MA0879.2 DLX1 MA0879.2 VYAATTAN DLX1 3.66e-19 3.03e-21 2600 94 67900 88.6 1.06 EAR_close
67 7 MA0899.1 HOXA10 MA0899.1 DGYMATAAAAH HOXA10 6.64e-19 5.41e-21 2370 85.7 60200 78.5 1.09 EAR_close
68 14 MA0602.1 Arid5a MA0602.1 SYAATATTGVDANH Arid5a 1.43e-18 1.15e-20 2350 85 59600 77.8 1.09 EAR_close
69 15 MA0018.4 CREB1 MA0018.4 NNRTGATGTCAYN CREB1 2.65e-18 2.1e-20 2150 77.5 53200 69.4 1.12 EAR_close
70 8 MA0705.1 Lhx8 MA0705.1 CTAATTAV Lhx8 5.14e-18 4.01e-20 1740 63 41400 54 1.17 EAR_close
71 16 MA0035.4 GATA1 MA0035.4 NHCTAATCTDH GATA1 7.35e-18 5.65e-20 615 22.2 11800 15.4 1.45 EAR_close
72 8 MA1495.1 HOXA1 MA1495.1 STAATTAS HOXA1 7.89e-18 5.98e-20 1490 53.9 34500 45 1.2 EAR_close
73 2 MA0140.2 GATA1::TAL1 MA0140.2 MTTATCWSNNNNNHVCAG GATA1::TAL1 8.7e-18 6.51e-20 884 31.9 18400 24 1.33 EAR_close
74 7 MA0052.4 MEF2A MA0052.4 DDCTAAAAATAGMHH MEF2A 1.24e-17 9.13e-20 2240 80.8 56100 73.2 1.1 EAR_close
75 8 MA0708.2 MSX2 MA0708.2 SCAATTAV MSX2 1.76e-17 1.28e-19 2160 78 53700 70.1 1.11 EAR_close
76 8 MA0885.2 Dlx2 MA0885.2 NDGCAATTAGNN Dlx2 1.81e-17 1.3e-19 2600 93.9 67900 88.6 1.06 EAR_close
77 9 MA1606.1 Foxf1 MA1606.1 DWRTAAACANN Foxf1 2.01e-17 1.43e-19 2440 88.1 62500 81.5 1.08 EAR_close
78 11 MA1115.1 POU5F1 MA1115.1 WHATGCAAATN POU5F1 2.24e-17 1.57e-19 2670 96.4 70500 92 1.05 EAR_close
79 13 MA0650.3 Hoxa13 MA0650.3 NNCCAATAAAAN Hoxa13 3.31e-17 2.29e-19 2500 90.2 64500 84.1 1.07 EAR_close
80 9 MA0848.1 FOXO4 MA0848.1 GTAAACA FOXO4 3.95e-17 2.7e-19 2500 90.2 64500 84.2 1.07 EAR_close
81 16 MA0648.1 GSC MA0648.1 VYTAATCCSY GSC 4.96e-17 3.34e-19 2500 90.1 64400 84.1 1.07 EAR_close
82 9 MA0481.3 FOXP1 MA0481.3 NDGTAAACANH FOXP1 6.15e-17 4.1e-19 2620 94.6 68800 89.8 1.05 EAR_close
83 15 MA0829.2 SREBF1 MA0829.2 DNATCACSTGATNH SREBF1 8.49e-17 5.59e-19 2020 72.9 49600 64.7 1.13 EAR_close
84 9 MA1103.2 FOXK2 MA1103.2 DDGTAAACANN FOXK2 9.38e-17 6.1e-19 2710 97.8 72200 94.3 1.04 EAR_close
85 9 MA1607.1 Foxl2 MA1607.1 DDWATGTAAACANN Foxl2 1.08e-16 6.96e-19 2460 88.8 63300 82.6 1.08 EAR_close
86 8 MA0662.1 MIXL1 MA0662.1 NBYAATTAVN MIXL1 1.96e-16 1.25e-18 2570 92.7 67000 87.4 1.06 EAR_close
87 9 MA0041.2 FOXD3 MA0041.2 WAWGHAAATAAACARY FOXD3 2.5e-16 1.57e-18 2400 86.8 61600 80.3 1.08 EAR_close
88 8 MA1549.1 POU6F1 MA1549.1 RTAATGAGVN POU6F1 3.15e-16 1.95e-18 1480 53.5 34400 44.9 1.19 EAR_close
89 8 MA0658.1 LHX6 MA0658.1 RCTAATTARY LHX6 6.4e-16 3.93e-18 1960 70.7 47900 62.6 1.13 EAR_close
90 17 MA0635.1 BARHL2 MA0635.1 VHTAAAYGRT BARHL2 7.84e-16 4.76e-18 2300 83.2 58400 76.2 1.09 EAR_close
91 7 MA0790.1 POU4F1 MA0790.1 ATGMATAATTAATG POU4F1 9.28e-16 5.57e-18 2100 75.9 52300 68.2 1.11 EAR_close
92 8 MA1500.1 HOXB6 MA1500.1 BTAATKRC HOXB6 9.59e-16 5.69e-18 2610 94.4 68700 89.6 1.05 EAR_close
93 8 MA0892.1 GSX1 MA0892.1 NCYMATTAVN GSX1 1.92e-15 1.13e-17 2310 83.6 58800 76.7 1.09 EAR_close
94 15 MA0025.2 NFIL3 MA0025.2 NRTTATGYAATNN NFIL3 1.97e-15 1.14e-17 2410 87.2 62000 80.9 1.08 EAR_close
95 15 MA0093.3 USF1 MA0093.3 NDGTCATGTGACHN USF1 2.6e-15 1.5e-17 1460 52.6 33900 44.2 1.19 EAR_close
96 8 MA0793.1 POU6F2 MA0793.1 ASCTMATTAW POU6F2 3.72e-15 2.12e-17 1860 67.1 45200 59 1.14 EAR_close
97 8 MA0717.1 RAX2 MA0717.1 YYAATTAV RAX2 3.81e-15 2.15e-17 2750 99.5 74500 97.2 1.02 EAR_close
98 8 MA0068.2 PAX4 MA0068.2 CTAATTAG PAX4 5.81e-15 3.24e-17 2480 89.6 64300 83.9 1.07 EAR_close
99 9 MA0033.2 FOXL1 MA0033.2 RTAAACA FOXL1 8.92e-15 4.92e-17 2450 88.6 63400 82.7 1.07 EAR_close
100 8 MA0704.1 Lhx4 MA0704.1 YTAATTAR Lhx4 9.57e-15 5.23e-17 1950 70.4 48000 62.6 1.13 EAR_close
101 15 MA1636.1 CEBPG MA1636.1 NDATGATGCAATMHH CEBPG 1.08e-14 5.83e-17 2130 76.8 53200 69.5 1.11 EAR_close
102 9 MA0157.3 Foxo3 MA0157.3 NDGTAAACARNN Foxo3 1.3e-14 6.94e-17 2720 98.4 73100 95.4 1.03 EAR_close
103 18 MA0842.2 NRL MA0842.2 AAWWNTGCTGACG NRL 1.73e-14 9.18e-17 915 33.1 19700 25.7 1.29 EAR_close
104 8 MA1530.1 NKX6-3 MA1530.1 VYCATTAWW NKX6-3 3.9e-14 2.05e-16 1500 54.2 35400 46.2 1.17 EAR_close
105 9 MA0846.1 FOXC2 MA0846.1 WAWGTAAACAWW FOXC2 3.99e-14 2.08e-16 2260 81.8 57600 75.1 1.09 EAR_close
106 8 MA0700.2 LHX2 MA0700.2 DDCCAATTADN LHX2 4.31e-14 2.22e-16 2240 80.7 56600 73.9 1.09 EAR_close
107 15 MA1143.1 FOSL1::JUND MA1143.1 RTGACGTMAY FOSL1::JUND 7.37e-14 3.77e-16 2210 79.7 55800 72.8 1.09 EAR_close
108 8 MA0706.1 MEOX2 MA0706.1 DSTAATTAWN MEOX2 8.41e-14 4.25e-16 1910 68.9 46900 61.2 1.13 EAR_close
109 8 MA0661.1 MEOX1 MA0661.1 VSTAATTAHC MEOX1 8.8e-14 4.41e-16 1450 52.4 34000 44.4 1.18 EAR_close
110 8 MA0628.1 POU6F1 MA0628.1 AYTAATTART POU6F1 1.84e-13 9.16e-16 1950 70.5 48300 63 1.12 EAR_close
111 4 MA0077.1 SOX9 MA0077.1 CYATTGTTY SOX9 2.08e-13 1.02e-15 2590 93.6 68300 89.1 1.05 EAR_close
112 9 MA0148.4 FOXA1 MA0148.4 WWGTAAACATNN FOXA1 2.24e-13 1.09e-15 2360 85.4 60700 79.2 1.08 EAR_close
113 9 MA1683.1 FOXA3 MA1683.1 DWGTAAACANN FOXA3 2.62e-13 1.26e-15 2690 97.2 71800 93.7 1.04 EAR_close
114 8 MA0902.2 HOXB2 MA0902.2 SYAATTAS HOXB2 3.27e-13 1.57e-15 1570 56.6 37400 48.8 1.16 EAR_close
115 31 MA1632.1 ATF2 MA1632.1 NNATGABGTCATN ATF2 4.08e-13 1.94e-15 704 25.4 14600 19.1 1.33 EAR_close
116 19 MA0050.3 Irf1 MA0050.3 ANTGAAACTGAAASH Irf1 4.3e-13 2.03e-15 2550 92 66700 87.1 1.06 EAR_close
117 20 MA0122.3 Nkx3-2 MA0122.3 WWAAMCACTTAAN Nkx3-2 6.49e-13 3.03e-15 2220 80.2 56400 73.6 1.09 EAR_close
118 8 MA0876.1 BSX MA0876.1 SYVATTAV BSX 7.71e-13 3.57e-15 2250 81.2 57200 74.7 1.09 EAR_close
119 8 MA0720.1 Shox2 MA0720.1 YYAATTAR Shox2 1.34e-12 6.14e-15 1820 65.8 44700 58.3 1.13 EAR_close
120 3 MA0797.1 TGIF2 MA0797.1 TGACAGSTGTCA TGIF2 1.67e-12 7.62e-15 992 35.8 22100 28.8 1.25 EAR_close
121 16 MA0891.1 GSC2 MA0891.1 NYTAATCCBH GSC2 2.06e-12 9.32e-15 2590 93.7 68500 89.4 1.05 EAR_close
122 15 MA0595.1 SREBF1 MA0595.1 VTCACCCCAY SREBF1 3.57e-12 1.6e-14 790 28.5 16900 22.1 1.29 EAR_close
123 8 MA0882.1 DLX6 MA0882.1 VYAATTAN DLX6 4.99e-12 2.22e-14 1980 71.6 49500 64.6 1.11 EAR_close
124 7 MA0901.2 HOXB13 MA0901.2 WDCCAATAAAAWWW HOXB13 5.26e-12 2.32e-14 2180 78.7 55300 72.2 1.09 EAR_close
125 8 MA0722.1 VAX1 MA0722.1 YTAATTAH VAX1 6.11e-12 2.67e-14 2000 72.1 49900 65.1 1.11 EAR_close
126 21 MA0606.2 Nfat5 MA0606.2 NNATGGAAAAWN Nfat5 9.86e-12 4.27e-14 2700 97.5 72400 94.4 1.03 EAR_close
127 8 MA0158.2 HOXA5 MA0158.2 GYMATTAS HOXA5 1.43e-11 6.14e-14 1310 47.4 30700 40.1 1.18 EAR_close
128 8 MA0723.2 VAX2 MA0723.2 BYAATTAV VAX2 1.62e-11 6.9e-14 2010 72.5 50400 65.7 1.1 EAR_close
129 22 MA1657.1 ZNF652 MA1657.1 BAAAGRGTTAAN ZNF652 1.7e-11 7.21e-14 2290 82.7 58800 76.7 1.08 EAR_close
130 8 MA0904.2 HOXB5 MA0904.2 STAATTAS HOXB5 1.83e-11 7.68e-14 1720 62 42000 54.8 1.13 EAR_close
131 9 MA0042.2 FOXI1 MA0042.2 GTAAACA FOXI1 1.96e-11 8.16e-14 2380 86 61600 80.4 1.07 EAR_close
132 17 MA1608.1 Isl1 MA1608.1 NNCCATTAGNN Isl1 2.17e-11 8.98e-14 2390 86.4 62000 80.9 1.07 EAR_close
133 7 MA0465.2 CDX2 MA0465.2 NDGCAATAAAWN CDX2 3.19e-11 1.31e-13 2270 82.2 58400 76.2 1.08 EAR_close
134 15 MA0596.1 SREBF2 MA0596.1 RTGGGGTGAY SREBF2 3.28e-11 1.34e-13 531 19.2 10700 13.9 1.38 EAR_close
135 1 MA0659.3 Mafg MA0659.3 NWGMTGACTCAGCAN Mafg 5.65e-11 2.29e-13 2000 72.2 50200 65.5 1.1 EAR_close
136 23 MA1487.2 FOXE1 MA1487.2 VYTAAAYAAACAAH FOXE1 6.03e-11 2.42e-13 1850 67 46000 60 1.12 EAR_close
137 20 MA1471.1 BARX2 MA1471.1 NWWAAYMATTAN BARX2 6.91e-11 2.76e-13 2150 77.6 54600 71.2 1.09 EAR_close
138 7 MA0791.1 POU4F3 MA0791.1 RTGMATWATTAATGAR POU4F3 7.31e-11 2.89e-13 1960 71 49200 64.2 1.11 EAR_close
139 15 MA0492.1 JUND MA0492.1 DDDRATGABGTCATN JUND 8.75e-11 3.44e-13 619 22.4 12900 16.8 1.33 EAR_close
140 15 MA1139.1 FOSL2::JUNB MA1139.1 DATGACGTCATH FOSL2::JUNB 9.36e-11 3.65e-13 1360 49 32200 42 1.17 EAR_close
141 18 MA0117.2 Mafb MA0117.2 AWWNTGCTGACD Mafb 2.19e-10 8.47e-13 916 33.1 20500 26.8 1.24 EAR_close
142 1 MA0782.2 PKNOX1 MA0782.2 NNTGAGTGACAGVNN PKNOX1 3.21e-10 1.24e-12 2540 91.9 67100 87.5 1.05 EAR_close
143 8 MA0718.1 RAX MA0718.1 RYYAATTARH RAX 1.19e-09 4.54e-12 1900 68.6 47600 62.1 1.1 EAR_close
144 8 MA0903.1 HOXB3 MA0903.1 NNYMATTARN HOXB3 1.3e-09 4.92e-12 1950 70.5 49100 64.1 1.1 EAR_close
145 8 MA0914.1 ISL2 MA0914.1 GCAMTTAR ISL2 1.38e-09 5.21e-12 2560 92.5 67800 88.4 1.05 EAR_close
146 8 MA0788.1 POU3F3 MA0788.1 WWTATGCWAATTW POU3F3 1.49e-09 5.56e-12 1980 71.6 50000 65.2 1.1 EAR_close
147 8 MA0887.1 EVX1 MA0887.1 VVTAATTABS EVX1 1.75e-09 6.5e-12 2020 72.9 51100 66.6 1.09 EAR_close
148 8 MA0630.1 SHOX MA0630.1 HTAATTRR SHOX 1.96e-09 7.25e-12 1780 64.4 44400 57.9 1.11 EAR_close
149 11 MA0785.1 POU2F1 MA0785.1 AWTATGCWAATK POU2F1 2.1e-09 7.71e-12 2070 74.9 52800 68.8 1.09 EAR_close
150 19 MA1623.1 Stat2 MA1623.1 RGAAACAGAAASH Stat2 2.66e-09 9.7e-12 2560 92.6 67900 88.6 1.05 EAR_close
151 8 MA1498.2 HOXA7 MA1498.2 SYMATTAV HOXA7 2.7e-09 9.75e-12 2080 75.1 52900 69.1 1.09 EAR_close
152 7 MA0680.2 Pax7 MA0680.2 DWTAATCAATTAWNH Pax7 3.11e-09 1.12e-11 1670 60.3 41100 53.7 1.12 EAR_close
153 9 MA0480.2 Foxo1 MA0480.2 NDGTAAACANN Foxo1 6.44e-09 2.3e-11 2710 97.9 73200 95.5 1.03 EAR_close
154 4 MA0868.2 SOX8 MA0868.2 MGAACAATRG SOX8 8.03e-09 2.85e-11 2350 85 61300 80 1.06 EAR_close
155 15 MA1126.1 FOS::JUN MA1126.1 DRTGACGTCATHNDTN FOS::JUN 9.86e-09 3.47e-11 1840 66.3 46000 60 1.1 EAR_close
156 12 MA1991.1 Hnf1A MA1991.1 NBCCTTTGATSTBN Hnf1A 1.22e-08 4.26e-11 2670 96.5 71800 93.6 1.03 EAR_close
157 24 MA0664.1 MLXIPL MA0664.1 RTCACGTGAT MLXIPL 1.24e-08 4.31e-11 1560 56.4 38300 49.9 1.13 EAR_close
158 15 MA1131.1 FOSL2::JUN MA1131.1 GRTGACGTMAT FOSL2::JUN 1.64e-08 5.68e-11 1370 49.5 33000 43.1 1.15 EAR_close
159 4 MA0442.2 SOX10 MA0442.2 NDAACAAAGVN SOX10 2.66e-08 9.13e-11 2530 91.3 66900 87.3 1.05 EAR_close
160 4 MA1563.2 SOX18 MA1563.2 AACAATDV SOX18 2.72e-08 9.29e-11 2020 72.8 51300 67 1.09 EAR_close
161 3 MA0775.1 MEIS3 MA0775.1 DTGACAGS MEIS3 3.12e-08 1.06e-10 2500 90.3 66000 86.1 1.05 EAR_close
162 10 MA1523.1 MSANTD3 MA1523.1 STVCACTCAC MSANTD3 3.45e-08 1.16e-10 2270 82 58900 76.8 1.07 EAR_close
163 8 MA1960.1 MGA::EVX1 MA1960.1 RGGTGWTAATKD MGA::EVX1 4.79e-08 1.61e-10 1560 56.4 38400 50.1 1.13 EAR_close
164 20 MA0124.2 Nkx3-1 MA0124.2 RCCACTTAA Nkx3-1 5.2e-08 1.73e-10 2120 76.5 54400 70.9 1.08 EAR_close
165 8 MA0890.1 GBX2 MA0890.1 RSYAATTARN GBX2 6.12e-08 2.03e-10 1340 48.3 32300 42.2 1.15 EAR_close
166 8 MA0875.1 BARX1 MA0875.1 VCMATTAV BARX1 1.23e-07 4.06e-10 2100 75.7 53800 70.2 1.08 EAR_close
167 8 MA0612.2 EMX1 MA0612.2 BTAATTAS EMX1 1.36e-07 4.45e-10 1320 47.5 31800 41.5 1.15 EAR_close
168 15 MA0833.2 ATF4 MA0833.2 DDATGATGCAATMN ATF4 1.39e-07 4.53e-10 1300 46.9 31300 40.9 1.15 EAR_close
169 8 MA1496.1 HOXA4 MA1496.1 RTMATTAV HOXA4 1.4e-07 4.54e-10 2170 78.5 56100 73.2 1.07 EAR_close
170 20 MA0672.1 NKX2-3 MA0672.1 VCCACTTRAV NKX2-3 2.23e-07 7.18e-10 1740 63 43700 57 1.1 EAR_close
171 7 MA0679.2 ONECUT1 MA0679.2 WAAAAATCAATAAWWN ONECUT1 2.45e-07 7.83e-10 1760 63.6 44200 57.6 1.1 EAR_close
172 25 MA1593.1 ZNF317 MA1593.1 WVACAGCAGAYW ZNF317 2.98e-07 9.45e-10 2400 86.8 63100 82.4 1.05 EAR_close
173 9 MA0850.1 FOXP3 MA0850.1 RTAAACA FOXP3 3.07e-07 9.69e-10 2730 98.8 74300 96.9 1.02 EAR_close
174 13 MA1644.1 NFYC MA1644.1 RDCCAATCASN NFYC 3.52e-07 1.1e-09 2370 85.7 62200 81.2 1.06 EAR_close
175 11 MA0142.1 Pou5f1::Sox2 MA0142.1 CWTTGTYATGCAAAT Pou5f1::Sox2 4.18e-07 1.31e-09 1910 69.2 48700 63.5 1.09 EAR_close
176 26 MA0095.3 Yy1 MA0095.3 NNCAAAATGGCN Yy1 4.36e-07 1.35e-09 2690 97.1 72500 94.6 1.03 EAR_close
177 27 MA0809.2 TEAD4 MA0809.2 NNACATTCCARN TEAD4 4.89e-07 1.51e-09 2320 83.6 60500 79 1.06 EAR_close
178 8 MA0880.1 Dlx3 MA0880.1 NYAATTAN Dlx3 5.45e-07 1.67e-09 1440 52.2 35500 46.3 1.13 EAR_close
179 12 MA0523.1 TCF7L2 MA0523.1 DRASATCAAAGRVA TCF7L2 6.98e-07 2.13e-09 1440 52 35300 46.1 1.13 EAR_close
180 17 MA0877.3 BARHL1 MA0877.3 AMCGTTTA BARHL1 8.34e-07 2.53e-09 2400 86.9 63300 82.6 1.05 EAR_close
181 17 MA1978.1 ZNF354A MA1978.1 HWAADWATAAATGRAYWAWTT ZNF354A 8.46e-07 2.55e-09 2080 75.1 53500 69.9 1.08 EAR_close
182 8 MA0724.1 VENTX MA0724.1 AMCGATTAR VENTX 9.94e-07 2.98e-09 1630 59 40800 53.3 1.11 EAR_close
183 28 MA1480.1 DPRX MA1480.1 AGATAATCCN DPRX 1.05e-06 3.15e-09 766 27.7 17400 22.7 1.22 EAR_close
184 8 MA0786.1 POU3F1 MA0786.1 WTATGCWAATKW POU3F1 1.07e-06 3.17e-09 1790 64.7 45300 59.1 1.1 EAR_close
185 1 MA1114.1 PBX3 MA1114.1 NNNTGAGTGACAGGBNN PBX3 1.3e-06 3.85e-09 2400 86.7 63200 82.5 1.05 EAR_close
186 29 MA1119.1 SIX2 MA1119.1 NNCTGAAACCTGATMY SIX2 1.43e-06 4.21e-09 1960 71 50300 65.6 1.08 EAR_close
187 15 MA0488.1 JUN MA0488.1 DDRATGATGTCAT JUN 1.44e-06 4.22e-09 550 19.9 11900 15.6 1.28 EAR_close
188 30 MA1572.1 TGIF2LY MA1572.1 TGACAGCTGTCA TGIF2LY 1.46e-06 4.23e-09 1150 41.6 27700 36.1 1.15 EAR_close
189 8 MA0132.2 PDX1 MA0132.2 VYAATTAR PDX1 1.97e-06 5.69e-09 1580 56.9 39300 51.3 1.11 EAR_close
190 8 MA1481.1 DRGX MA1481.1 YYAATTAN DRGX 2.19e-06 6.29e-09 1390 50.1 34100 44.4 1.13 EAR_close
191 31 MA0592.3 (ESRRA) STREME-4 4-AGGTCA AGGTCA ESRRA 4.66e-06 1.33e-08 2460 88.9 65200 85.1 1.04 EAR_close
192 32 MA0805.1 TBX1 MA0805.1 AGGTGTGA TBX1 5.66e-06 1.61e-08 708 25.6 16100 21 1.22 EAR_close
193 46 MA0090.3 TEAD1 MA0090.3 NNACATTCCAGSN TEAD1 6.01e-06 1.7e-08 2460 88.9 65200 85.1 1.04 EAR_close
194 4 MA1120.1 SOX13 MA1120.1 DVACAATGGNN SOX13 6.18e-06 1.74e-08 2420 87.6 64100 83.6 1.05 EAR_close
195 33 MA1643.1 NFIB MA1643.1 NNCCTGGCAYNGTGCCAAGNN NFIB 6.57e-06 1.84e-08 212 7.66 3880 5.07 1.52 EAR_close
196 10 MA0063.2 NKX2-5 MA0063.2 NNCACTCAANN NKX2-5 6.68e-06 1.86e-08 1490 53.8 37000 48.3 1.11 EAR_close
197 8 MA0912.2 HOXD3 MA0912.2 CTAATTAC HOXD3 7.82e-06 2.17e-08 1100 39.8 26500 34.6 1.15 EAR_close
198 32 MA0802.1 TBR1 MA0802.1 AGGTGTGAAA TBR1 8.35e-06 2.3e-08 345 12.5 7020 9.16 1.36 EAR_close
199 34 MA1603.1 Dmrt1 MA1603.1 GHTACAAAGTADC Dmrt1 1.08e-05 2.97e-08 2110 76.2 54700 71.4 1.07 EAR_close
200 35 MA1720.1 ZNF85 MA1720.1 DHDGAGATTACWKCAK ZNF85 1.22e-05 3.33e-08 1330 47.9 32600 42.6 1.13 EAR_close
201 8 MA0886.1 EMX2 MA0886.1 VBTAATTARB EMX2 1.27e-05 3.45e-08 1470 53 36500 47.6 1.11 EAR_close
202 15 MA0656.1 JDP2 MA0656.1 GATGACGTCAYC JDP2 1.28e-05 3.46e-08 235 8.49 4450 5.8 1.47 EAR_close
203 30 MA1571.1 TGIF2LX MA1571.1 TGACAGCTGTCA TGIF2LX 1.44e-05 3.88e-08 842 30.4 19700 25.6 1.19 EAR_close
204 27 MA0808.1 TEAD3 MA0808.1 RCATTCCW TEAD3 1.77e-05 4.75e-08 1660 60 41900 54.7 1.1 EAR_close
205 15 MA0834.1 ATF7 MA0834.1 NDATGACGTCATMV ATF7 2.38e-05 6.35e-08 318 11.5 6440 8.41 1.37 EAR_close
206 36 MA1707.1 DMRTA1 MA1707.1 AWTTGWTACAWT DMRTA1 2.41e-05 6.4e-08 1720 62.3 43800 57.1 1.09 EAR_close
207 15 MA1133.1 JUN::JUNB MA1133.1 KRTGACGTCATN JUN::JUNB 2.82e-05 7.44e-08 1280 46.1 31400 41 1.13 EAR_close
208 37 MA1627.1 (Wt1) STREME-6 6-CCTCCCCCA CCTCCCCCA Wt1 3.35e-05 8.8e-08 316 11.4 6420 8.37 1.37 EAR_close
209 8 MA0699.1 LBX2 MA0699.1 NCYAATTARN LBX2 3.94e-05 1.03e-07 1220 43.9 29800 38.8 1.13 EAR_close
210 4 MA0867.2 SOX4 MA0867.2 RAACAAAGRV SOX4 4.49e-05 1.17e-07 2390 86.3 63200 82.5 1.05 EAR_close
211 32 MA0803.1 TBX15 MA0803.1 AGGTGTGA TBX15 4.79e-05 1.24e-07 621 22.4 14100 18.3 1.22 EAR_close
212 21 MA0624.2 Nfatc1 MA0624.2 NVATGGAAAAWN Nfatc1 5.52e-05 1.42e-07 2560 92.5 68600 89.5 1.03 EAR_close
213 15 MA1129.1 FOSL1::JUN MA1129.1 ATGACGTCAT FOSL1::JUN 5.9e-05 1.51e-07 966 34.9 23100 30.1 1.16 EAR_close
214 15 MA1145.1 FOSL2::JUND MA1145.1 NNRTGACGTCAYHSN FOSL2::JUND 5.98e-05 1.53e-07 1700 61.3 43100 56.2 1.09 EAR_close
215 15 MA1136.1 FOSB::JUNB MA1136.1 RTGACGTCAT FOSB::JUNB 6.79e-05 1.72e-07 1750 63.3 44700 58.3 1.09 EAR_close
216 33 MA0119.1 NFIC::TLX1 MA0119.1 TGGCASSRWGCCAA NFIC::TLX1 8.17e-05 2.07e-07 225 8.13 4320 5.64 1.45 EAR_close
217 4 MA0143.4 SOX2 MA0143.4 DNACAATGGNN SOX2 9.3e-05 2.34e-07 2230 80.6 58500 76.4 1.05 EAR_close
218 20 MA2003.1 NKX2-4 MA2003.1 CCACTTSAVV NKX2-4 0.000125 3.14e-07 451 16.3 9840 12.8 1.27 EAR_close
219 45 MA0508.3 PRDM1 MA0508.3 YNCTTTCTCTH PRDM1 0.00013 3.25e-07 2630 95 71000 92.6 1.03 EAR_close
220 15 MA1127.1 FOSB::JUN MA1127.1 GATGACGTCAT FOSB::JUN 0.000149 3.71e-07 1750 63.3 44800 58.4 1.08 EAR_close
221 38 MA0151.1 Arid3a MA0151.1 ATYAAA Arid3a 0.000157 3.88e-07 1330 48.2 33200 43.3 1.11 EAR_close
222 33 MA1528.1 NFIX MA1528.1 STTGGCRNNGTGCCARB NFIX 0.000164 4.04e-07 143 5.17 2500 3.26 1.59 EAR_close
223 8 MA0787.1 POU3F2 MA0787.1 WTATGCWAATKA POU3F2 0.000169 4.13e-07 1730 62.5 44200 57.7 1.08 EAR_close
224 8 MA0888.1 EVX2 MA0888.1 VVTAATTAVB EVX2 0.00017 4.15e-07 1810 65.3 46400 60.5 1.08 EAR_close
225 8 MA0900.2 HOXA2 MA0900.2 STAATTAS HOXA2 0.000184 4.46e-07 820 29.6 19400 25.3 1.17 EAR_close
226 18 MA0495.3 MAFF MA0495.3 DWGTCAGCATTTTWHN MAFF 0.000214 5.18e-07 577 20.8 13100 17.1 1.22 EAR_close
227 35 MA0611.2 Dux MA0611.2 NTGATTBAATCAVWNN Dux 0.000223 5.36e-07 828 29.9 19600 25.6 1.17 EAR_close
228 15 MA0840.1 Creb5 MA0840.1 NATGACGTCAYH Creb5 0.000285 6.83e-07 366 13.2 7800 10.2 1.3 EAR_close
229 8 MA0854.1 Alx1 MA0854.1 CGMRYTAATTARTNMNY Alx1 0.00031 7.4e-07 1210 43.9 30000 39.1 1.12 EAR_close
230 15 MA1951.1 FOS MA1951.1 BGATGACGTCATCR FOS 0.000318 7.55e-07 610 22 14000 18.2 1.21 EAR_close
231 39 MA0755.1 CUX2 MA0755.1 TRATCGATAW CUX2 0.000324 7.67e-07 1900 68.6 49100 64.1 1.07 EAR_close
232 33 MA1527.1 NFIC MA1527.1 NTTGGCDNNRTGCCARN NFIC 0.000363 8.55e-07 77 2.78 1130 1.48 1.91 EAR_close
233 8 MA0709.1 Msx3 MA0709.1 SCAATTAN Msx3 0.000506 1.19e-06 1020 36.8 24800 32.4 1.14 EAR_close
234 21 MA0152.2 Nfatc2 MA0152.2 NNRNAATGGAAANWNH Nfatc2 0.000641 1.5e-06 2610 94.2 70300 91.7 1.03 EAR_close
235 4 MA0078.2 Sox17 MA0078.2 NNAGAACAATGGNN Sox17 0.000681 1.58e-06 2560 92.4 68800 89.7 1.03 EAR_close
236 40 MA1729.1 ZNF680 MA1729.1 GNCCAAGAAGAATDA ZNF680 0.000697 1.61e-06 1770 64 45600 59.5 1.08 EAR_close
237 24 MA1570.1 TFAP4 MA1570.1 AHCATRTGDT TFAP4 0.000819 1.89e-06 906 32.7 21800 28.5 1.15 EAR_close
238 4 MA0514.2 Sox3 MA0514.2 DNACAATGGNN Sox3 0.000919 2.11e-06 2360 85.1 62600 81.6 1.04 EAR_close
239 32 MA0688.1 TBX2 MA0688.1 DAGGTGTGAAA TBX2 0.000952 2.18e-06 507 18.3 11400 14.9 1.23 EAR_close
240 8 MA0666.2 MSX1 MA0666.2 SCAATTAR MSX1 0.00102 2.31e-06 608 22 14000 18.3 1.2 EAR_close
241 8 MA1501.1 HOXB7 MA1501.1 GGTAATTAVS HOXB7 0.00115 2.61e-06 2000 72.4 52300 68.2 1.06 EAR_close
242 13 MA0060.3 NFYA MA0060.3 RRCCAATCAGM NFYA 0.0013 2.92e-06 2310 83.6 61300 80 1.04 EAR_close
243 32 MA0689.1 TBX20 MA0689.1 WAGGTGTGAAR TBX20 0.0018 4.06e-06 1640 59.2 42000 54.8 1.08 EAR_close
244 8 MA1519.1 LHX5 MA1519.1 STAATTAV LHX5 0.00182 4.07e-06 753 27.2 17900 23.4 1.17 EAR_close
245 15 MA0102.4 CEBPA MA0102.4 NDATTGCACAATHN CEBPA 0.00274 6.11e-06 2000 72.3 52300 68.3 1.06 EAR_close
246 7 MA0909.3 Hoxd13 MA0909.3 NNCAATAAAW Hoxd13 0.00314 6.97e-06 1790 64.7 46300 60.4 1.07 EAR_close
247 32 MA0806.1 TBX4 MA0806.1 AGGTGTGA TBX4 0.00353 7.81e-06 473 17.1 10700 14 1.22 EAR_close
248 8 MA0125.1 Nobox MA0125.1 TAATTRSY Nobox 0.00357 7.86e-06 1210 43.7 30200 39.5 1.11 EAR_close
249 44 MA0599.1 KLF5 MA0599.1 GCCCCDCCCH KLF5 0.00362 7.94e-06 1010 36.4 24700 32.3 1.13 EAR_close
250 8 MA1518.2 Lhx1 MA1518.2 NNNTGCTAATTAGCANNN Lhx1 0.00442 9.65e-06 862 31.1 20900 27.3 1.14 EAR_close
9 44 MA1596.1 (ZNF460) MEME-3 CCHCHSCCWCC CCHCHSCCWCC ZNF460 0.0045 5e-04 1000 36.3 25400 33.1 1.1 EAR_close
251 10 MA1645.1 NKX2-2 MA1645.1 NNNCCACTCAANNN NKX2-2 0.00452 9.84e-06 2040 73.7 53500 69.8 1.06 EAR_close
252 32 MA0807.1 TBX5 MA0807.1 AGGTGTKA TBX5 0.00459 9.94e-06 649 23.4 15300 20 1.18 EAR_close
253 8 MA0881.1 Dlx4 MA0881.1 VYAATTAN Dlx4 0.00462 9.97e-06 992 35.8 24400 31.8 1.13 EAR_close
254 30 MA0691.1 TFAP4 MA0691.1 AWCAGCTGWT TFAP4 0.00478 1.03e-05 1160 41.9 28900 37.7 1.11 EAR_close
255 41 MA0108.2 TBP MA0108.2 STATAAAWRSVVVBN TBP 0.0054 1.16e-05 1990 72 52200 68.1 1.06 EAR_close
256 42 MA0029.1 Mecom MA0029.1 AAGAYAAGATAANA Mecom 0.00659 1.41e-05 62 2.24 922 1.2 1.89 EAR_close
257 30 MA1638.1 HAND2 MA1638.1 NVCAGATGNN HAND2 0.00719 1.53e-05 422 15.2 9500 12.4 1.23 EAR_close
258 32 MA0800.1 EOMES MA0800.1 RAGGTGTGAAAWN EOMES 0.00815 1.72e-05 377 13.6 8380 10.9 1.25 EAR_close
259 3 MA0783.1 PKNOX2 MA0783.1 TGACAGGTGTCA PKNOX2 0.00852 1.8e-05 201 7.26 4060 5.3 1.38 EAR_close
260 20 MA1994.1 Nkx2-1 MA1994.1 NVCACTTGARHNN Nkx2-1 0.00861 1.81e-05 2680 96.7 72800 95 1.02 EAR_close
10 45 MA1731.1 (ZNF768) MEME-6 TCTCYYTMTCTCTYT TCTCYYTMTCTCTYT ZNF768 0.0091 0.00091 203 7.33 4440 5.79 1.27 EAR_close
261 31 MA1996.1 Nr1H2 MA1996.1 NNRAGGTCANN Nr1H2 0.011 2.31e-05 1000 36.2 24800 32.3 1.12 EAR_close
262 30 MA0816.1 Ascl2 MA0816.1 ARCAGCTGCY Ascl2 0.0118 2.47e-05 2140 77.2 56500 73.7 1.05 EAR_close
263 15 MA0639.1 DBP MA0639.1 NRTTACGTAAYV DBP 0.0157 3.26e-05 766 27.7 18500 24.2 1.15 EAR_close
264 31 MA0071.1 RORA MA0071.1 AWMWAGGTCA RORA 0.0166 3.45e-05 497 18 11500 15 1.2 EAR_close
265 9 MA0031.1 FOXD1 MA0031.1 GTAAACAW FOXD1 0.0169 3.49e-05 1550 55.8 39800 51.9 1.08 EAR_close
266 20 MA0898.1 Hmx3 MA0898.1 ASAAGCAATTAAWRRAT Hmx3 0.0182 3.75e-05 1780 64.3 46300 60.5 1.06 EAR_close
267 30 MA0461.2 Atoh1 MA0461.2 RMCATATGBY Atoh1 0.0187 3.82e-05 1460 52.7 37300 48.7 1.08 EAR_close
268 27 MA1121.1 TEAD2 MA1121.1 NYACATTCCWNNS TEAD2 0.019 3.88e-05 2660 95.9 72100 94.1 1.02 EAR_close
269 31 MA0017.2 NR2F1 MA0017.2 CARAGGTCAMVNG NR2F1 0.0199 4.05e-05 455 16.4 10500 13.6 1.21 EAR_close
270 31 MA1111.1 NR2F2 MA1111.1 NAAAGGTCANR NR2F2 0.0213 4.31e-05 1360 49.1 34600 45.2 1.09 EAR_close
271 30 MA1618.1 Ptf1a MA1618.1 NNACAGATGTTNN Ptf1a 0.024 4.83e-05 746 27 18100 23.6 1.14 EAR_close
272 32 MA0801.1 MGA MA0801.1 AGGTGTGA MGA 0.028 5.62e-05 371 13.4 8360 10.9 1.23 EAR_close
273 43 MA0164.1 Nr2e3 MA0164.1 CAAGCTT Nr2e3 0.0344 6.89e-05 595 21.5 14100 18.5 1.17 EAR_close
274 15 MA0836.2 CEBPD MA0836.2 NRTTGCACAAYHN CEBPD 0.0346 6.91e-05 2380 86.2 63900 83.4 1.03 EAR_close
275 8 MA0889.1 GBX1 MA0889.1 VCYAATTASY GBX1 0.0421 8.36e-05 545 19.7 12900 16.8 1.17 EAR_close
276 15 MA0828.2 SREBF2 MA0828.2 WWATCACGTGATWW SREBF2 0.048 9.5e-05 206 7.44 4310 5.62 1.33 EAR_close
11 46 MA0090.3 (TEAD1) MEME-4 CAYTCCAGCCT CAYTCCAGCCT TEAD1 0.0508 0.00462 13 0.47 142 0.19 2.71 EAR_close
12 47 GAGACRGRGTCTCRC MEME-7 GAGACRGRGTCTCRC GAGACRGRGTCTCRC GAGACRGRGTCTCRC 0.0912 0.0076 331 12 7980 10.4 1.15 EAR_close
13 48 8-AACTGTGGAGA STREME-8 8-AACTGTGGAGA AACTGTGGAGA AACTGTGGAGA 0.192 0.0148 397 14.3 9840 12.8 1.12 EAR_close
14 49 MA1125.1 (ZNF384) MEME-2 AAAAAAAAAAARAAA AAAAAAAAAAARAAA ZNF384 0.619 0.0442 28 1.01 533 0.7 1.5 EAR_close
15 50 MA1581.1 (ZBTB6) MEME-8 GGCTCAAGYGATYCT GGCTCAAGYGATYCT ZBTB6 1.34 0.0896 124 4.48 3020 3.94 1.15 EAR_close
16 51 GCCTGTARTCCCAGC MEME-5 GCCTGTARTCCCAGC GCCTGTARTCCCAGC GCCTGTARTCCCAGC 1.9 0.119 7 0.25 111 0.14 1.98 EAR_close 
ER_rat <- 1.25
mrc_type <- "EAR_close"
EAR_close_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

EAR_close_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*.8), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.8,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

ESR_open data

ESR_open_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_open_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
ESR_open_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_open_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
ESR_open_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_open_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
ESR_open_sea_all <- rbind(ESR_open_sea_disc, ESR_open_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)
ESR_open_combo <- ESR_open_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., ESR_open_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="ESR_open")

ESR_open_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")
Enriched motifs 200 bp in EAR open v NR
RANK CLUSTER SIM_MOTIF ALT_ID ID CONSENSUS.x motif_name EVALUE.y QVALUE TP TP. FP FP. ENR_RATIO mrc_type
1 1 10-CACACATGCACACAC STREME-10 10-CACACATGCACACAC 10-CACACATGCACACAC CACACATGCACACAC 1.8e-189 1.3e-189 549 9.72 1370 1.78 5.46 ESR_open
2 1 GTGYRTGTGTGTRTG MEME-7 GTGYRTGTGTGTRTG GTGYRTGTGTGTRTG GTGYRTGTGTGTRTG 9.06e-176 3.27e-176 537 9.5 1420 1.85 5.14 ESR_open
3 1 MA1107.2 (KLF9) MEME-1 TGTGTGTGTGTGTGT TGTGTGTGTGTGTGT KLF9 5.74e-169 1.38e-169 476 8.42 1140 1.48 5.68 ESR_open
4 1 MA1107.2 (KLF9) STREME-3 3-ATGTGTGTGTG ATGTGTGTGTG KLF9 8.48e-155 1.53e-155 499 8.83 1390 1.82 4.87 ESR_open
5 1 2-CACACACAYACACA STREME-2 2-CACACACAYACACA CACACACAYACACA CACACACAYACACA 1.42e-145 2.05e-146 409 7.24 967 1.26 5.74 ESR_open
6 1 ACACAYRYACACACA MEME-8 ACACAYRYACACACA ACACAYRYACACACA ACACAYRYACACACA 1.82e-144 2.19e-145 423 7.49 1050 1.37 5.46 ESR_open
7 2 MA1990.1 (Gli1) STREME-4 4-ACACACCACACACAC ACACACCACACACAC Gli1 3.29e-134 3.39e-135 267 4.73 375 0.49 9.67 ESR_open
8 2 ACACACCACACACA MEME-6 ACACACCACACACA ACACACCACACACA ACACACCACACACA 5.12e-133 4.62e-134 204 3.61 164 0.21 16.9 ESR_open
9 1 6-GTGTGTRTG STREME-6 6-GTGTGTRTG GTGTGTRTG GTGTGTRTG 9.95e-132 7.98e-133 757 13.4 3510 4.58 2.93 ESR_open
10 1 MA1107.2 (KLF9) MEME-11 CAYACACACACACAY CAYACACACACACAY KLF9 1.58e-120 1.14e-121 360 6.37 910 1.19 5.37 ESR_open
11 3 MA0491.2 (JUND) STREME-1 1-DATGASTCATH DATGASTCATH JUND 3.23e-120 2.12e-121 698 12.4 3250 4.24 2.92 ESR_open
12 3 MA0477.2 FOSL1 MA0477.2 NNATGACTCATNN FOSL1 1.1e-103 6.59e-105 765 13.5 4130 5.39 2.51 ESR_open
13 3 MA0491.2 JUND MA0491.2 NNATGACTCATNN JUND 4.66e-103 2.59e-104 820 14.5 4630 6.04 2.41 ESR_open
14 3 MA0490.2 JUNB MA0490.2 NNATGACTCATNN JUNB 4.3e-102 2.22e-103 785 13.9 4340 5.66 2.46 ESR_open
15 3 MA0462.2 BATF::JUN MA0462.2 DATGACTCATH BATF::JUN 7.98e-99 3.84e-100 687 12.2 3570 4.65 2.62 ESR_open
16 3 MA0835.2 BATF3 MA0835.2 DATGACTCATH BATF3 1.41e-98 6.37e-100 609 10.8 2930 3.82 2.82 ESR_open
17 3 MA0476.1 (FOS) MEME-4 TGASTCAT TGASTCAT FOS 1.78e-98 7.55e-100 1150 20.3 7860 10.2 1.98 ESR_open
18 2 TGTGTGGTGTGTGTG MEME-2 TGTGTGGTGTGTGTG TGTGTGGTGTGTGTG TGTGTGGTGTGTGTG 2.06e-98 8.28e-100 331 5.86 949 1.24 4.74 ESR_open
19 3 MA0099.3 FOS::JUN MA0099.3 ATGAGTCAYM FOS::JUN 1.36e-97 5.16e-99 572 10.1 2650 3.46 2.93 ESR_open
20 3 MA1141.1 FOS::JUND MA1141.1 NKATGAGTCATNN FOS::JUND 2.01e-97 7.25e-99 719 12.7 3870 5.05 2.52 ESR_open
21 3 MA1128.1 FOSL1::JUN MA1128.1 NKATGACTCATNN FOSL1::JUN 1.95e-95 6.72e-97 864 15.3 5210 6.8 2.25 ESR_open
22 3 MA1134.1 FOS::JUNB MA1134.1 KATGASTCATHN FOS::JUNB 5.64e-95 1.85e-96 935 16.6 5890 7.69 2.15 ESR_open
23 3 MA1634.1 BATF MA1634.1 DATGACTCATH BATF 6.01e-95 1.88e-96 699 12.4 3750 4.9 2.53 ESR_open
24 3 MA1144.1 FOSL2::JUND MA1144.1 KATGACTCAT FOSL2::JUND 5.57e-94 1.67e-95 900 15.9 5590 7.29 2.19 ESR_open
25 3 MA1137.1 FOSL1::JUNB MA1137.1 NDRTGACTCATNN FOSL1::JUNB 1.94e-92 5.6e-94 828 14.6 4960 6.47 2.27 ESR_open
26 3 MA1142.1 FOSL1::JUND MA1142.1 NRTGACTCAT FOSL1::JUND 5.46e-92 1.52e-93 819 14.5 4890 6.38 2.27 ESR_open
27 3 MA1988.1 Atf3 MA1988.1 NRTGACTCABN Atf3 7.93e-92 2.12e-93 643 11.4 3340 4.36 2.61 ESR_open
28 3 MA1138.1 FOSL2::JUNB MA1138.1 KRTGASTCAT FOSL2::JUNB 7.75e-89 2e-90 1060 18.8 7320 9.55 1.97 ESR_open
29 3 MA0655.1 JDP2 MA0655.1 ATGACTCAT JDP2 2.65e-87 6.59e-89 551 9.75 2670 3.49 2.8 ESR_open
30 3 MA1135.1 FOSB::JUNB MA1135.1 KRTGASTCAT FOSB::JUNB 2.12e-86 5.11e-88 1100 19.4 7720 10.1 1.92 ESR_open
31 3 MA1130.1 FOSL2::JUN MA1130.1 NNRTGAGTCAYN FOSL2::JUN 4.78e-86 1.11e-87 530 9.38 2530 3.3 2.85 ESR_open
32 3 MA1633.2 BACH1 MA1633.2 ATGACTCAT BACH1 4.12e-85 9.3e-87 493 8.73 2250 2.94 2.97 ESR_open
33 3 MA0489.2 Jun MA0489.2 NVTGACTCATNN Jun 4.93e-82 1.08e-83 890 15.8 5830 7.61 2.07 ESR_open
34 4 MA1155.1 ZSCAN4 MA1155.1 TGCACACACTGAAAA ZSCAN4 1.85e-81 3.92e-83 481 8.51 2220 2.9 2.94 ESR_open
35 3 MA0841.1 NFE2 MA0841.1 VATGACTCATS NFE2 4.22e-79 8.7e-81 478 8.46 2240 2.93 2.89 ESR_open
36 3 MA1101.2 BACH2 MA1101.2 DWANCATGASTCATSNTWH BACH2 5.19e-77 1.04e-78 707 12.5 4250 5.55 2.26 ESR_open
37 3 MA1132.1 JUN::JUNB MA1132.1 KATGACKCAT JUN::JUNB 6.28e-76 1.23e-77 405 7.17 1740 2.27 3.17 ESR_open
38 3 MA0476.1 FOS MA0476.1 DVTGASTCATB FOS 5.1e-75 9.68e-77 1210 21.5 9380 12.2 1.76 ESR_open
39 3 MA0478.1 FOSL2 MA0478.1 KRRTGASTCAB FOSL2 8.47e-73 1.57e-74 1120 19.9 8520 11.1 1.79 ESR_open
40 5 MA0106.3 TP53 MA0106.3 RACATGYCCGGRCATGTY TP53 6.85e-72 1.24e-73 519 9.19 2720 3.55 2.59 ESR_open
41 1 5-CATACA STREME-5 5-CATACA CATACA CATACA 1.45e-63 2.56e-65 2510 44.4 25300 33 1.35 ESR_open
42 3 MA1928.1 BNC2 MA1928.1 NDRTGAGTCABN BNC2 1.08e-61 1.85e-63 625 11.1 3910 5.1 2.17 ESR_open
43 6 MA0525.2 (TP63) STREME-11 11-ACATGT 11-ACATGT TP63 1.71e-54 2.86e-56 3070 54.4 33300 43.4 1.25 ESR_open
44 7 MA1108.2 MXI1 MA1108.2 NNCACATGBN MXI1 1.41e-51 2.32e-53 2910 51.5 31300 40.9 1.26 ESR_open
45 8 7-ATGTAC STREME-7 7-ATGTAC ATGTAC ATGTAC 9.75e-43 1.56e-44 2920 51.7 32200 42 1.23 ESR_open
46 5 MA0861.1 TP73 MA0861.1 DRCATGTCNNRACAYGYM TP73 8.89e-41 1.4e-42 742 13.1 5800 7.57 1.74 ESR_open
47 9 MA1974.1 ZNF211 MA1974.1 HWYATATACCAYRYW ZNF211 2.58e-38 3.96e-40 2430 43 26100 34.1 1.26 ESR_open
48 6 MA0525.2 TP63 MA0525.2 RACATGTYGKGACATGTC TP63 6.52e-30 9.8e-32 138 2.44 511 0.67 3.68 ESR_open
49 10 MA0006.1 Ahr::Arnt MA0006.1 YGCGTG Ahr::Arnt 4.89e-29 7.21e-31 523 9.26 4030 5.25 1.76 ESR_open
50 11 MA0851.1 Foxj3 MA0851.1 NDAADGTAAACAAANNM Foxj3 2.99e-28 4.31e-30 3320 58.7 38900 50.8 1.16 ESR_open
51 11 MA0148.4 FOXA1 MA0148.4 WWGTAAACATNN FOXA1 2.03e-27 2.88e-29 2270 40.2 25100 32.7 1.23 ESR_open
52 12 MA0073.1 RREB1 MA0073.1 CCCCMAAMCAMCCMCMMMCV RREB1 4.18e-27 5.8e-29 530 9.38 4180 5.46 1.72 ESR_open
53 3 MA0089.2 MAFG::NFE2L1 MA0089.2 NVNATGACTCAGCADW MAFG::NFE2L1 4.74e-25 6.45e-27 549 9.72 4480 5.84 1.67 ESR_open
54 11 MA0849.1 FOXO6 MA0849.1 GTAAACA FOXO6 5.51e-25 7.36e-27 3870 68.4 46900 61.2 1.12 ESR_open
55 7 MA0623.2 NEUROG1 MA0623.2 RACATATGTY NEUROG1 7e-24 9.19e-26 1550 27.4 16200 21.2 1.29 ESR_open
56 13 MA1115.1 POU5F1 MA1115.1 WHATGCAAATN POU5F1 3.79e-23 4.89e-25 2380 42 26800 35 1.2 ESR_open
57 13 MA0789.1 POU3F4 MA0789.1 TATGCWAAT POU3F4 1.36e-22 1.73e-24 3480 61.6 41800 54.6 1.13 ESR_open
58 14 MA1107.2 KLF9 MA1107.2 MNGCCACACCCACHYV KLF9 2.54e-22 3.16e-24 745 13.2 6790 8.85 1.49 ESR_open
59 7 MA0626.1 Npas2 MA0626.1 NSCACGTGTN Npas2 2.6e-22 3.18e-24 2210 39.2 24800 32.4 1.21 ESR_open
60 11 MA1606.1 Foxf1 MA1606.1 DWRTAAACANN Foxf1 4.79e-22 5.76e-24 2750 48.7 31900 41.7 1.17 ESR_open
61 7 MA0678.1 OLIG2 MA0678.1 AMCATATGKT OLIG2 1.2e-21 1.42e-23 3000 53.1 35300 46.1 1.15 ESR_open
62 3 MA0501.1 MAF::NFE2 MA0501.1 ATGACTCAGCANWTY MAF::NFE2 1e-20 1.16e-22 520 9.2 4390 5.72 1.61 ESR_open
63 7 MA0819.2 CLOCK MA0819.2 NRACACGTGB CLOCK 1.27e-20 1.46e-22 3070 54.3 36400 47.4 1.14 ESR_open
64 9 MA1718.1 ZNF8 MA1718.1 GTATGGATATACCACAKTTT ZNF8 1.3e-20 1.47e-22 520 9.2 4390 5.73 1.61 ESR_open
65 13 MA0627.2 POU2F3 MA0627.2 NWTATGCAAATNH POU2F3 1.54e-20 1.71e-22 2100 37.3 23600 30.8 1.21 ESR_open
66 11 MA0033.2 FOXL1 MA0033.2 RTAAACA FOXL1 2.41e-20 2.64e-22 3080 54.5 36600 47.7 1.14 ESR_open
67 11 MA0848.1 FOXO4 MA0848.1 GTAAACA FOXO4 1.03e-18 1.1e-20 5120 90.6 66200 86.4 1.05 ESR_open
68 7 MA0622.1 Mlxip MA0622.1 BCACGTGK Mlxip 1.04e-18 1.1e-20 93 1.65 358 0.47 3.55 ESR_open
69 15 MA1125.1 (ZNF384) MEME-3 WWTTTTTWTWWTTTT WWTTTTTWTWWTTTT ZNF384 1.75e-18 1.83e-20 1630 28.9 17800 23.2 1.24 ESR_open
70 3 MA0496.3 MAFK MA0496.3 NGMTGACTCAGCMNH MAFK 1.82e-18 1.88e-20 2140 38 24400 31.8 1.19 ESR_open
71 11 MA0847.3 FOXD2 MA0847.3 SYTAARYAAACA FOXD2 1.95e-18 1.99e-20 2440 43.2 28300 36.9 1.17 ESR_open
72 7 MA0259.1 ARNT::HIF1A MA0259.1 VBACGTGC ARNT::HIF1A 2.65e-18 2.66e-20 507 8.97 4380 5.71 1.57 ESR_open
73 3 MA1124.1 ZNF24 MA1124.1 CATTCATTCATTC ZNF24 4.01e-18 3.97e-20 1560 27.7 17000 22.2 1.25 ESR_open
74 13 MA0785.1 POU2F1 MA0785.1 AWTATGCWAATK POU2F1 2.12e-17 2.07e-19 4400 77.9 55500 72.4 1.08 ESR_open
75 13 MA0786.1 POU3F1 MA0786.1 WTATGCWAATKW POU3F1 2.73e-17 2.62e-19 4160 73.6 51900 67.8 1.09 ESR_open
76 11 MA1103.2 FOXK2 MA1103.2 DDGTAAACANN FOXK2 8.18e-17 7.77e-19 4870 86.2 62500 81.5 1.06 ESR_open
77 16 9-ATKHYWRDMAT STREME-9 9-ATKHYWRDMAT ATKHYWRDMAT ATKHYWRDMAT 1.58e-16 1.48e-18 1090 19.3 11300 14.7 1.31 ESR_open
78 11 MA0852.2 FOXK1 MA0852.2 NRDGTAAACAAGNN FOXK1 2.3e-16 2.12e-18 4720 83.6 60300 78.7 1.06 ESR_open
79 11 MA1487.2 FOXE1 MA1487.2 VYTAAAYAAACAAH FOXE1 5.79e-16 5.29e-18 2400 42.4 28000 36.5 1.16 ESR_open
80 17 MA0052.4 (MEF2A) STREME-8 8-AHAAATATTTT AHAAATATTTT MEF2A 6.45e-16 5.81e-18 728 12.9 7030 9.17 1.41 ESR_open
81 3 MA1479.1 DMRTC2 MA1479.1 AATTGMTACATT DMRTC2 1.31e-15 1.16e-17 4120 72.8 51600 67.3 1.08 ESR_open
82 11 MA0047.3 FOXA2 MA0047.3 RWGTAAACANN FOXA2 1.81e-15 1.59e-17 1340 23.7 14400 18.8 1.26 ESR_open
83 7 MA0059.1 MAX::MYC MA0059.1 RASCACGTGGT MAX::MYC 2.99e-15 2.6e-17 2040 36.1 23400 30.5 1.18 ESR_open
84 11 MA0480.2 Foxo1 MA0480.2 NDGTAAACANN Foxo1 3.82e-15 3.27e-17 4200 74.4 52900 69 1.08 ESR_open
85 11 MA1978.1 ZNF354A MA1978.1 HWAADWATAAATGRAYWAWTT ZNF354A 3.85e-15 3.27e-17 1640 29 18300 23.8 1.22 ESR_open
86 11 MA0613.1 FOXG1 MA0613.1 RTAAACAW FOXG1 6.74e-15 5.65e-17 2550 45.1 30100 39.3 1.15 ESR_open
87 11 MA1607.1 Foxl2 MA1607.1 DDWATGTAAACANN Foxl2 9.6e-15 7.96e-17 4230 74.9 53400 69.6 1.08 ESR_open
88 18 MA0804.1 TBX19 MA0804.1 DTTMRCACMTAGGTGTGAAW TBX19 7.04e-14 5.77e-16 1610 28.4 18000 23.5 1.21 ESR_open
89 11 MA1683.1 FOXA3 MA1683.1 DWGTAAACANN FOXA3 3.59e-13 2.91e-15 728 12.9 7250 9.46 1.36 ESR_open
90 7 MA0818.2 BHLHE22 MA0818.2 AMCATATGKY BHLHE22 6.01e-13 4.82e-15 1720 30.4 19500 25.5 1.19 ESR_open
91 7 MA0827.1 OLIG3 MA0827.1 AMCATATGBY OLIG3 1.36e-12 1.08e-14 1960 34.8 22800 29.7 1.17 ESR_open
92 11 MA0614.1 Foxj2 MA0614.1 RTAAACAA Foxj2 2.83e-12 2.22e-14 2420 42.9 28800 37.6 1.14 ESR_open
93 11 MA0846.1 FOXC2 MA0846.1 WAWGTAAACAWW FOXC2 7.65e-12 5.94e-14 2680 47.5 32400 42.2 1.12 ESR_open
94 7 MA0823.1 HEY1 MA0823.1 GRCACGTGCC HEY1 1.34e-11 1.03e-13 172 3.04 1200 1.56 1.96 ESR_open
95 7 MA0004.1 Arnt MA0004.1 CACGTG Arnt 1.97e-11 1.5e-13 123 2.18 744 0.97 2.26 ESR_open
96 19 MA0791.1 POU4F3 MA0791.1 RTGMATWATTAATGAR POU4F3 4.16e-11 3.12e-13 2020 35.7 23700 30.9 1.16 ESR_open
97 11 MA0845.1 FOXB1 MA0845.1 WATGTAAATAT FOXB1 5.6e-11 4.17e-13 2090 37 24700 32.2 1.15 ESR_open
98 13 MA0788.1 POU3F3 MA0788.1 WWTATGCWAATTW POU3F3 5.83e-11 4.29e-13 3940 69.7 49700 64.9 1.07 ESR_open
99 11 MA0042.2 FOXI1 MA0042.2 GTAAACA FOXI1 6.5e-11 4.74e-13 4120 72.9 52300 68.2 1.07 ESR_open
100 20 MA1603.1 Dmrt1 MA1603.1 GHTACAAAGTADC Dmrt1 6.95e-11 5.01e-13 3810 67.4 47900 62.5 1.08 ESR_open
101 11 MA0157.3 Foxo3 MA0157.3 NDGTAAACARNN Foxo3 7.26e-11 5.19e-13 4970 88 64700 84.4 1.04 ESR_open
102 11 MA0481.3 FOXP1 MA0481.3 NDGTAAACANH FOXP1 9.65e-11 6.83e-13 5370 95.1 71000 92.6 1.03 ESR_open
103 21 CTCCCRARKWGCTGG MEME-5 CTCCCRARKWGCTGG CTCCCRARKWGCTGG CTCCCRARKWGCTGG 1.42e-10 9.93e-13 181 3.2 1320 1.72 1.87 ESR_open
104 7 MA1106.1 HIF1A MA1106.1 SBACGTGCNN HIF1A 2.16e-10 1.5e-12 274 4.85 2290 2.99 1.63 ESR_open
105 22 MA1561.1 SOX12 MA1561.1 ACCGAACAATV SOX12 2.25e-10 1.55e-12 3960 70.1 50200 65.5 1.07 ESR_open
106 18 MA0689.1 TBX20 MA0689.1 WAGGTGTGAAR TBX20 2.91e-10 1.98e-12 3840 68 48500 63.3 1.07 ESR_open
107 23 MA1602.1 ZSCAN29 MA1602.1 YGTCTACRCNGN ZSCAN29 3.97e-10 2.68e-12 1830 32.4 21400 27.9 1.16 ESR_open
108 11 MA0041.2 FOXD3 MA0041.2 WAWGHAAATAAACARY FOXD3 4.18e-10 2.8e-12 1750 30.9 20300 26.5 1.17 ESR_open
109 3 MA1113.2 PBX2 MA1113.2 NHCATAAATCAHN PBX2 5.13e-10 3.4e-12 2880 51 35300 46 1.11 ESR_open
110 3 MA0150.2 Nfe2l2 MA0150.2 CASNATGACTCAGCA Nfe2l2 7.31e-10 4.8e-12 2210 39.2 26400 34.5 1.14 ESR_open
111 11 MA0030.1 FOXF2 MA0030.1 BNAASGTAAACAAD FOXF2 7.73e-10 5.03e-12 1230 21.7 13700 17.9 1.22 ESR_open
112 19 MA0790.1 POU4F1 MA0790.1 ATGMATAATTAATG POU4F1 1.86e-09 1.2e-11 1430 25.4 16400 21.4 1.19 ESR_open
113 7 MA0817.1 BHLHE23 MA0817.1 AAACATATGBTN BHLHE23 5.14e-09 3.28e-11 1150 20.3 12800 16.7 1.22 ESR_open
114 2 MA1989.1 Bcl11B MA1989.1 NNAAACCACAARNN Bcl11B 8.81e-09 5.58e-11 4540 80.4 58700 76.6 1.05 ESR_open
115 7 MA1560.1 SOHLH2 MA1560.1 YGCACGTGCN SOHLH2 2.16e-08 1.35e-10 205 3.63 1660 2.17 1.68 ESR_open
116 18 MA0805.1 TBX1 MA0805.1 AGGTGTGA TBX1 3.28e-08 2.04e-10 524 9.27 5270 6.88 1.35 ESR_open
117 24 MA0102.4 CEBPA MA0102.4 NDATTGCACAATHN CEBPA 3.5e-08 2.16e-10 1660 29.4 19500 25.4 1.16 ESR_open
118 25 TGGCTCAYGCCTGTA MEME-9 TGGCTCAYGCCTGTA TGGCTCAYGCCTGTA TGGCTCAYGCCTGTA 7.52e-08 4.6e-10 178 3.15 1410 1.83 1.73 ESR_open
119 11 MA0108.2 TBP MA0108.2 STATAAAWRSVVVBN TBP 8.28e-08 5.02e-10 3080 54.5 38400 50.1 1.09 ESR_open
120 7 MA1493.1 HES6 MA1493.1 GGCACGTGTY HES6 1.79e-07 1.08e-09 489 8.65 4920 6.42 1.35 ESR_open
121 11 MA0032.2 FOXC1 MA0032.2 WAWGTAAAYAW FOXC1 5.6e-07 3.34e-09 2200 38.8 26700 34.8 1.12 ESR_open
122 14 MA0807.1 TBX5 MA0807.1 AGGTGTKA TBX5 8.1e-07 4.79e-09 1000 17.7 11300 14.7 1.21 ESR_open
123 26 MA0773.1 MEF2D MA0773.1 DCTAWAAATAGM MEF2D 1.35e-06 7.89e-09 777 13.8 8500 11.1 1.24 ESR_open
124 7 MA0825.1 MNT MA0825.1 RVCACGTGMH MNT 2.3e-06 1.34e-08 3630 64.3 46200 60.4 1.07 ESR_open
125 11 MA0442.2 SOX10 MA0442.2 NDAACAAAGVN SOX10 4.25e-06 2.45e-08 4320 76.5 56000 73.1 1.05 ESR_open
126 7 MA0464.2 BHLHE40 MA0464.2 VKCACGTGMC BHLHE40 5.09e-06 2.92e-08 172 3.04 1430 1.87 1.64 ESR_open
127 21 12-GCACTTTGGGAGGC STREME-12 12-GCACTTTGGGAGGC 12-GCACTTTGGGAGGC GCACTTTGGGAGGC 5.58e-06 3.17e-08 65 1.15 377 0.49 2.37 ESR_open
128 11 MA0031.1 FOXD1 MA0031.1 GTAAACAW FOXD1 5.91e-06 3.33e-08 1940 34.4 23600 30.7 1.12 ESR_open
129 20 MA0143.4 SOX2 MA0143.4 DNACAATGGNN SOX2 6.92e-06 3.87e-08 3290 58.3 41700 54.4 1.07 ESR_open
130 7 MA0871.2 TFEC MA0871.2 NVCACGTGACN TFEC 1.09e-05 6.05e-08 1320 23.4 15500 20.3 1.16 ESR_open
131 3 MA1639.1 MEIS1 MA1639.1 NHCATMAATCAHN MEIS1 1.18e-05 6.5e-08 4300 76 55700 72.7 1.05 ESR_open
132 7 MA0608.1 Creb3l2 MA0608.1 GCCACGTGD Creb3l2 1.35e-05 7.38e-08 511 9.04 5370 7 1.29 ESR_open
133 20 MA0514.2 Sox3 MA0514.2 DNACAATGGNN Sox3 1.73e-05 9.4e-08 3530 62.5 45000 58.8 1.06 ESR_open
134 7 MA0698.1 ZBTB18 MA0698.1 NATCCAGATGTKB ZBTB18 2.65e-05 1.43e-07 1540 27.3 18500 24.1 1.14 ESR_open
135 2 MA1990.1 Gli1 MA1990.1 NNRGACCACCCASV Gli1 2.75e-05 1.47e-07 358 6.34 3580 4.67 1.36 ESR_open
136 7 MA0821.2 HES5 MA0821.2 GRCACGTGYC HES5 2.97e-05 1.58e-07 276 4.88 2630 3.43 1.43 ESR_open
137 7 MA0147.3 MYC MA0147.3 NNCCACGTGCNB MYC 5.08e-05 2.68e-07 238 4.21 2220 2.89 1.46 ESR_open
138 7 MA0649.1 HEY2 MA0649.1 GRCACGTGYC HEY2 6.86e-05 3.59e-07 299 5.29 2920 3.82 1.39 ESR_open
139 7 MA0461.2 Atoh1 MA0461.2 RMCATATGBY Atoh1 7.65e-05 3.97e-07 2170 38.4 26800 35 1.1 ESR_open
140 11 MA0679.2 ONECUT1 MA0679.2 WAAAAATCAATAAWWN ONECUT1 7.72e-05 3.98e-07 1830 32.5 22300 29.1 1.11 ESR_open
141 18 MA0806.1 TBX4 MA0806.1 AGGTGTGA TBX4 9.54e-05 4.88e-07 1220 21.6 14400 18.7 1.15 ESR_open
142 11 MA0850.1 FOXP3 MA0850.1 RTAAACA FOXP3 0.000128 6.5e-07 3190 56.4 40500 52.9 1.07 ESR_open
143 7 MA0122.3 Nkx3-2 MA0122.3 WWAAMCACTTAAN Nkx3-2 0.000204 1.03e-06 3000 53.1 38000 49.6 1.07 ESR_open
144 14 MA1523.1 MSANTD3 MA1523.1 STVCACTCAC MSANTD3 0.000226 1.13e-06 528 9.35 5710 7.45 1.26 ESR_open
145 7 MA1620.1 Ptf1A MA1620.1 NVACACCTGTNN Ptf1A 0.000259 1.28e-06 1170 20.7 13800 18 1.15 ESR_open
146 7 MA0826.1 OLIG1 MA0826.1 AMCATATGKT OLIG1 0.00026 1.28e-06 536 9.49 5820 7.59 1.25 ESR_open
147 7 MA0058.3 MAX MA0058.3 AVCACGTGNY MAX 0.000303 1.49e-06 2760 48.8 34800 45.4 1.08 ESR_open
148 7 MA1559.1 SNAI3 MA1559.1 RRCAGGTGYA SNAI3 0.000437 2.12e-06 1540 27.3 18600 24.3 1.12 ESR_open
149 13 MA0043.3 HLF MA0043.3 NNRTTATGCAACHN HLF 0.000439 2.12e-06 2300 40.8 28700 37.5 1.09 ESR_open
150 13 MA0619.1 LIN54 MA0619.1 DTTTRAATH LIN54 0.000714 3.44e-06 750 13.3 8530 11.1 1.19 ESR_open
151 7 MA1621.1 Rbpjl MA1621.1 NNVACACCTGTBNN Rbpjl 0.000781 3.73e-06 1120 19.8 13200 17.2 1.15 ESR_open
152 24 MA0836.2 CEBPD MA0836.2 NRTTGCACAAYHN CEBPD 0.000829 3.94e-06 4610 81.6 60500 78.9 1.03 ESR_open
153 26 MA0660.1 MEF2B MA0660.1 RCTAWAAATAGC MEF2B 0.00105 4.96e-06 861 15.2 9960 13 1.17 ESR_open
154 3 MA1640.1 MEIS2 MA1640.1 NNATGATTTATGDNH MEIS2 0.00118 5.52e-06 2280 40.4 28600 37.2 1.08 ESR_open
155 7 MA0603.1 Arntl MA0603.1 NGTCACGTGH Arntl 0.00129 5.99e-06 398 7.04 4220 5.5 1.28 ESR_open
156 2 MA0002.2 Runx1 MA0002.2 BBYTGTGGTTT Runx1 0.00151 6.96e-06 3710 65.6 47900 62.5 1.05 ESR_open
157 27 13-GTCTCTACTAAAA STREME-13 13-GTCTCTACTAAAA 13-GTCTCTACTAAAA GTCTCTACTAAAA 0.00163 7.49e-06 221 3.91 2140 2.79 1.41 ESR_open
158 3 MA0659.3 Mafg MA0659.3 NWGMTGACTCAGCAN Mafg 0.00164 7.49e-06 2630 46.6 33300 43.4 1.07 ESR_open
159 14 MA0801.1 MGA MA0801.1 AGGTGTGA MGA 0.00263 1.19e-05 501 8.87 5510 7.19 1.24 ESR_open
160 28 MA1546.1 PAX3 MA1546.1 YSGTCACGSYWATTAN PAX3 0.00283 1.28e-05 3270 57.8 42000 54.7 1.06 ESR_open
161 29 MA1960.1 MGA::EVX1 MA1960.1 RGGTGWTAATKD MGA::EVX1 0.00313 1.4e-05 3020 53.4 38600 50.3 1.06 ESR_open
162 14 MA0632.2 TCFL5 MA0632.2 KCACGCGCMC TCFL5 0.00322 1.44e-05 2010 35.6 25100 32.7 1.09 ESR_open
163 30 MA0908.1 HOXD11 MA0908.1 RTCGTAAAAH HOXD11 0.00551 2.44e-05 1730 30.6 21400 27.9 1.1 ESR_open
164 7 MA0620.3 MITF MA0620.3 NNNDRTCACGTGAYHNNN MITF 0.00597 2.63e-05 2260 39.9 28400 37 1.08 ESR_open
165 31 MA1580.1 ZBTB32 MA1580.1 TGTACAGTAW ZBTB32 0.0132 5.78e-05 1340 23.8 16400 21.4 1.11 ESR_open
24 34 TTGAGSYCAGGAGTT MEME-12 TTGAGSYCAGGAGTT TTGAGSYCAGGAGTT TTGAGSYCAGGAGTT 0.0135 0.000562 46 0.81 357 0.47 1.78 ESR_open
166 22 MA0868.2 SOX8 MA0868.2 MGAACAATRG SOX8 0.0151 6.56e-05 5140 91.1 68500 89.3 1.02 ESR_open
167 32 MA0902.2 HOXB2 MA0902.2 SYAATTAS HOXB2 0.0174 7.53e-05 3570 63.2 46300 60.4 1.05 ESR_open
168 7 MA0692.1 TFEB MA0692.1 RYCACGTGAC TFEB 0.0192 8.23e-05 3140 55.6 40500 52.8 1.05 ESR_open
169 19 MA0046.2 HNF1A MA0046.2 DRTTAATNATTAACN HNF1A 0.0283 0.000121 2080 36.8 26200 34.1 1.08 ESR_open
170 19 MA0683.1 POU4F2 MA0683.1 RTGCATAATTAATGAG POU4F2 0.0285 0.000121 589 10.4 6760 8.81 1.18 ESR_open
171 32 MA0710.1 NOTO MA0710.1 NYTAATTAVN NOTO 0.0308 0.00013 4570 80.8 60200 78.6 1.03 ESR_open
172 33 MA0757.1 ONECUT3 MA0757.1 AAAAAATCRATAAH ONECUT3 0.0449 0.000188 1450 25.6 17900 23.3 1.1 ESR_open
173 18 MA0802.1 TBR1 MA0802.1 AGGTGTGAAA TBR1 0.0483 0.000201 368 6.51 4040 5.27 1.24 ESR_open
25 35 MA0090.3 (TEAD1) MEME-10 AGGCTGGAGTGCAGT AGGCTGGAGTGCAGT TEAD1 2.57 0.103 177 3.13 2170 2.83 1.11 ESR_open 
ER_rat <- 1.25
mrc_type <- "ESR_open"
ESR_open_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

ESR_open_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*10), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./10,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

ESR_close data

ESR_close_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_close_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
ESR_close_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_close_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
ESR_close_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_close_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
ESR_close_sea_all <- rbind(ESR_close_sea_disc, ESR_close_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)
ESR_close_combo <- ESR_close_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., ESR_close_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="ESR_close")

ESR_close_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")
Enriched motifs 200 bp in EAR open v NR
RANK CLUSTER SIM_MOTIF ALT_ID ID CONSENSUS.x motif_name EVALUE.y QVALUE TP TP. FP FP. ENR_RATIO mrc_type
1 1 MA0774.1 (MEIS2) STREME-1 1-CTGWCAG CTGWCAG MEIS2 2.24e-135 1.58e-135 4660 65.3 38300 49.9 1.31 ESR_close
2 1 MA0797.1 (TGIF2) STREME-10 10-SCTGTCA 10-SCTGTCA TGIF2 4.08e-118 1.44e-118 2640 37 18400 24 1.54 ESR_close
3 2 MA1653.1 (ZNF148) STREME-2 2-CCCWSCCC CCCWSCCC ZNF148 1.01e-112 2.38e-113 5030 70.4 43500 56.8 1.24 ESR_close
4 1 MA0774.1 MEIS2 MA0774.1 TTGACAGS MEIS2 5.18e-111 9.15e-112 3170 44.3 23700 30.9 1.43 ESR_close
5 3 MA1565.1 (TBX18) STREME-6 6-CACCTCY CACCTCY TBX18 7.08e-93 1e-93 2870 40.2 21600 28.2 1.43 ESR_close
6 2 MA1522.1 (MAZ) MEME-1 GRGGWGGRGGSAGGG GRGGWGGRGGSAGGG MAZ 3.53e-90 4.16e-91 2790 39.1 21000 27.4 1.43 ESR_close
7 4 MA0599.1 KLF5 MA0599.1 GCCCCDCCCH KLF5 8.13e-84 8.2e-85 2890 40.4 22200 29 1.4 ESR_close
8 4 MA0493.2 KLF1 MA0493.2 DGGGYGGGG KLF1 4.77e-70 4.21e-71 2520 35.3 19300 25.2 1.4 ESR_close
9 5 3-CAGSCTG STREME-3 3-CAGSCTG CAGSCTG CAGSCTG 1.78e-67 1.32e-68 2560 35.9 19900 25.9 1.39 ESR_close
10 6 MA1643.1 NFIB MA1643.1 NNCCTGGCAYNGTGCCAAGNN NFIB 1.87e-67 1.32e-68 813 11.4 4300 5.61 2.03 ESR_close
11 7 MA0808.1 (TEAD3) MEME-3 SWGGVAKG SWGGVAKG TEAD3 2.03e-65 1.31e-66 4150 58.1 36300 47.4 1.23 ESR_close
12 8 MA1645.1 (NKX2-2) STREME-11 11-CCTCTCA 11-CCTCTCA NKX2-2 1.84e-62 1.08e-63 5290 74 49200 64.2 1.15 ESR_close
13 4 MA1630.2 ZNF281 MA1630.2 GGGGGAGGGGVV ZNF281 2.3e-60 1.25e-61 1070 15 6600 8.61 1.75 ESR_close
14 4 MA1511.2 KLF10 MA1511.2 GGGGCGGGG KLF10 5.84e-57 2.95e-58 3960 55.5 34800 45.4 1.22 ESR_close
15 1 MA0775.1 MEIS3 MA0775.1 DTGACAGS MEIS3 6.44e-57 3.03e-58 2220 31 17100 22.3 1.39 ESR_close
16 1 MA0498.2 MEIS1 MA0498.2 HTGACAD MEIS1 8.27e-57 3.65e-58 4000 56 35200 45.9 1.22 ESR_close
17 9 GCYCTGRG MEME-9 GCYCTGRG GCYCTGRG GCYCTGRG 3.94e-56 1.64e-57 2870 40.2 23500 30.7 1.31 ESR_close
18 4 MA0740.2 KLF14 MA0740.2 KGGGCGGGG KLF14 1.37e-55 5.38e-57 2600 36.5 20900 27.3 1.34 ESR_close
19 6 MA0119.1 NFIC::TLX1 MA0119.1 TGGCASSRWGCCAA NFIC::TLX1 1.78e-55 6.6e-57 828 11.6 4750 6.2 1.87 ESR_close
20 4 MA0039.4 KLF4 MA0039.4 NNCCCCACCCHN KLF4 7.04e-54 2.48e-55 6200 86.8 60700 79.2 1.09 ESR_close
21 4 MA1965.1 SP5 MA1965.1 CBCCTCCCHS SP5 1.4e-53 4.71e-55 2290 32.1 18000 23.5 1.37 ESR_close
22 10 MA1721.1 (ZNF93) MEME-2 CWGCAGCH CWGCAGCH ZNF93 3.38e-53 1.08e-54 3480 48.8 30000 39.2 1.25 ESR_close
23 4 MA0685.2 SP4 MA0685.2 GGGGCGGGG SP4 9.97e-53 3.06e-54 4470 62.6 40600 53 1.18 ESR_close
24 11 4-AGGCCAG STREME-4 4-AGGCCAG AGGCCAG AGGCCAG 2.38e-52 6.99e-54 6140 86 60200 78.5 1.1 ESR_close
25 4 MA1959.1 KLF7 MA1959.1 DGGGCGGGG KLF7 2.12e-50 5.99e-52 4450 62.4 40600 53 1.18 ESR_close
26 12 MA1726.1 (ZNF331) STREME-8 8-AGKGCC AGKGCC ZNF331 2.46e-50 6.67e-52 2400 33.6 19200 25 1.34 ESR_close
27 4 MA1653.1 ZNF148 MA1653.1 YBCCCCTCCCCC ZNF148 2.88e-50 7.54e-52 4310 60.3 39000 50.9 1.19 ESR_close
28 4 MA1522.1 MAZ MA1522.1 BBCCCCTCCCY MAZ 8.38e-50 2.11e-51 4540 63.6 41600 54.3 1.17 ESR_close
29 4 MA0742.2 KLF12 MA0742.2 GGGGCGGGG KLF12 1.54e-48 3.75e-50 4240 59.4 38400 50.2 1.19 ESR_close
30 4 MA0741.1 KLF16 MA0741.1 GMCACGCCCCC KLF16 4.47e-48 1.05e-49 2730 38.2 22600 29.5 1.29 ESR_close
31 13 MA1102.2 CTCFL MA1102.2 NSCAGGGGGCGS CTCFL 3.63e-46 8.27e-48 6280 87.9 62200 81.2 1.08 ESR_close
32 4 MA1961.1 PATZ1 MA1961.1 SSGGGGMGGGGS PATZ1 1.78e-45 3.92e-47 4160 58.3 37800 49.3 1.18 ESR_close
33 14 MA0672.1 (NKX2-3) STREME-7 7-CCACTTGA CCACTTGA NKX2-3 5.33e-45 1.14e-46 941 13.2 6040 7.87 1.67 ESR_close
34 4 MA0516.3 SP2 MA0516.3 GGGGCGGGG SP2 1.6e-43 3.31e-45 4400 61.7 40600 52.9 1.17 ESR_close
35 4 MA0753.2 ZNF740 MA0753.2 CYRCCCCCCCCAC ZNF740 4.24e-43 8.55e-45 4650 65.1 43300 56.5 1.15 ESR_close
36 15 MA1578.1 VEZF1 MA1578.1 CCCCCCMYDH VEZF1 9.76e-43 1.88e-44 4090 57.3 37200 48.6 1.18 ESR_close
37 4 MA0079.5 SP1 MA0079.5 GGGGCGGGG SP1 9.84e-43 1.88e-44 4340 60.8 39900 52 1.17 ESR_close
38 16 MA1650.1 ZBTB14 MA1650.1 SSCCGCGCACVS ZBTB14 3.1e-42 5.76e-44 5440 76.2 52400 68.4 1.12 ESR_close
39 4 MA0746.2 SP3 MA0746.2 NGCCACGCCCMCH SP3 4.46e-42 8.08e-44 3120 43.7 27000 35.3 1.24 ESR_close
40 14 MA0672.1 NKX2-3 MA0672.1 VCCACTTRAV NKX2-3 2.56e-40 4.51e-42 1040 14.6 7120 9.29 1.58 ESR_close
41 14 MA2003.1 NKX2-4 MA2003.1 CCACTTSAVV NKX2-4 1.36e-37 2.34e-39 1700 23.8 13300 17.3 1.38 ESR_close
42 4 MA1512.1 KLF11 MA1512.1 SCCACGCCCMC KLF11 2.58e-37 4.34e-39 4900 68.6 46500 60.7 1.13 ESR_close
43 17 MA1981.1 ZNF530 MA1981.1 GMARGGMRAGGGGCRGSV ZNF530 4.97e-37 8.17e-39 4310 60.4 40100 52.3 1.16 ESR_close
44 1 MA0797.1 TGIF2 MA0797.1 TGACAGSTGTCA TGIF2 3.19e-36 5.13e-38 2200 30.9 18200 23.8 1.3 ESR_close
45 4 MA1564.1 SP9 MA1564.1 RCCACGCCCMCY SP9 3.57e-35 5.6e-37 6220 87.1 62200 81.2 1.07 ESR_close
46 18 MA0810.1 TFAP2A MA0810.1 YGCCCBVRGGCR TFAP2A 9.15e-34 1.4e-35 5980 83.7 59400 77.5 1.08 ESR_close
47 19 MA0146.2 Zfx MA0146.2 SSSGCCBVGGCCTS Zfx 1.57e-33 2.35e-35 4850 67.9 46300 60.4 1.12 ESR_close
48 20 MA1728.1 (ZNF549) STREME-16 16-CTGCCCAC 16-CTGCCCAC ZNF549 1.04e-32 1.53e-34 3210 45 28700 37.4 1.2 ESR_close
49 4 MA1107.2 KLF9 MA1107.2 MNGCCACACCCACHYV KLF9 6.01e-32 8.66e-34 5600 78.4 55000 71.7 1.09 ESR_close
50 37 MA0766.2 GATA5 MA0766.2 SWGATAASRN GATA5 1.05e-30 1.49e-32 3190 44.6 28600 37.3 1.2 ESR_close
51 21 MA1981.1 (ZNF530) MEME-5 CAGRGSCWGGG CAGRGSCWGGG ZNF530 2.47e-30 3.43e-32 948 13.3 6720 8.77 1.51 ESR_close
52 22 MA0597.2 THAP1 MA0597.2 VSGCAGGGCASV THAP1 1.13e-29 1.54e-31 5660 79.3 55900 72.9 1.09 ESR_close
53 23 MA0803.1 TBX15 MA0803.1 AGGTGTGA TBX15 2.83e-29 3.77e-31 4280 59.9 40400 52.7 1.14 ESR_close
54 24 MA0830.2 TCF4 MA0830.2 NNGCACCTGCCNN TCF4 1.12e-28 1.47e-30 6560 91.8 66900 87.3 1.05 ESR_close
55 4 MA0747.1 SP8 MA0747.1 RCCACGCCCMCY SP8 1.24e-28 1.59e-30 4030 56.4 37700 49.2 1.15 ESR_close
56 6 MA0739.1 Hic1 MA0739.1 RTGCCAACY Hic1 3.74e-28 4.72e-30 2440 34.1 21100 27.6 1.24 ESR_close
57 25 MA0154.4 (EBF1) STREME-9 9-CCCWGGG CCCWGGG EBF1 7.82e-28 9.69e-30 901 12.6 6430 8.39 1.51 ESR_close
58 26 MA0814.2 TFAP2C MA0814.2 NNGCCTGAGGCGNN TFAP2C 9.18e-28 1.12e-29 6560 91.8 67000 87.4 1.05 ESR_close
59 27 MA1710.1 ZNF257 MA1710.1 VDGAGGCRAGRG ZNF257 1.32e-26 1.58e-28 5630 78.8 55800 72.8 1.08 ESR_close
60 28 MA1535.1 NR2C1 MA1535.1 NRRGGTCAN NR2C1 7.04e-26 8.15e-28 6250 87.6 63300 82.6 1.06 ESR_close
61 29 MA1713.1 ZNF610 MA1713.1 SSCGCCGCTCCSSS ZNF610 7.04e-26 8.15e-28 4230 59.3 40200 52.4 1.13 ESR_close
62 24 MA0522.3 TCF3 MA0522.3 NVCACCTGCNN TCF3 8.11e-26 9.24e-28 6780 94.9 70000 91.4 1.04 ESR_close
63 30 MA0162.4 EGR1 MA0162.4 VCMCGCCCACGCVS EGR1 1.26e-25 1.41e-27 4840 67.8 46900 61.2 1.11 ESR_close
64 14 MA0673.1 NKX2-8 MA0673.1 VCACTTSAV NKX2-8 2.39e-24 2.64e-26 1110 15.5 8520 11.1 1.4 ESR_close
65 24 MA0816.1 Ascl2 MA0816.1 ARCAGCTGCY Ascl2 5.45e-24 5.92e-26 4590 64.3 44300 57.8 1.11 ESR_close
66 18 MA0524.2 TFAP2C MA0524.2 YGCCYBVRGGCA TFAP2C 1.85e-23 1.98e-25 6420 89.9 65500 85.5 1.05 ESR_close
67 24 MA1635.1 BHLHE22 MA1635.1 NVCAGCTGBN BHLHE22 2.7e-23 2.84e-25 1290 18 10200 13.4 1.35 ESR_close
68 50 MA1628.1 Zic1::Zic2 MA1628.1 CVCAGCAGGNV Zic1::Zic2 5.31e-23 5.52e-25 6400 89.7 65400 85.3 1.05 ESR_close
69 24 MA1648.1 TCF12 MA1648.1 NNCACCTGCNN TCF12 5.6e-23 5.73e-25 6100 85.5 61700 80.5 1.06 ESR_close
70 18 MA0811.1 TFAP2B MA0811.1 YGCCCBVRGGCA TFAP2B 7.1e-23 7.16e-25 5870 82.2 59000 76.9 1.07 ESR_close
71 13 MA0155.1 INSM1 MA0155.1 TGYCWGGGGGCR INSM1 3.07e-22 3.05e-24 1220 17.1 9690 12.6 1.35 ESR_close
72 5 CCAGSCWG MEME-6 CCAGSCWG CCAGSCWG CCAGSCWG 4.12e-22 4.05e-24 766 10.7 5520 7.2 1.49 ESR_close
73 31 MA1615.1 Plagl1 MA1615.1 NNCTGGGGCCABN Plagl1 4.3e-22 4.15e-24 4770 66.7 46400 60.6 1.1 ESR_close
74 32 MA1548.1 PLAGL2 MA1548.1 NGGGCCCCCN PLAGL2 1.09e-21 1.04e-23 3470 48.6 32500 42.4 1.15 ESR_close
75 33 MA1514.1 KLF17 MA1514.1 MMCCACGCACCCMTY KLF17 3.77e-21 3.55e-23 4230 59.2 40600 53 1.12 ESR_close
76 1 MA1571.1 TGIF2LX MA1571.1 TGACAGCTGTCA TGIF2LX 1.28e-20 1.19e-22 3000 42 27600 36 1.17 ESR_close
77 4 MA1515.1 KLF2 MA1515.1 NRCCACRCCCH KLF2 1.47e-20 1.35e-22 6580 92.2 67800 88.4 1.04 ESR_close
78 34 MA0528.2 ZNF263 MA0528.2 VNGGGGAGGASG ZNF263 5.38e-20 4.87e-22 6470 90.6 66400 86.6 1.05 ESR_close
79 35 MA0842.2 (NRL) STREME-13 13-AAGTCTGCTGAAGC 13-AAGTCTGCTGAAGC NRL 8.16e-20 7.29e-22 30 0.42 13 0.02 23.8 ESR_close
80 24 MA1997.1 Olig2 MA1997.1 NVCAGCTGBN Olig2 1.24e-19 1.1e-21 1110 15.5 8800 11.5 1.35 ESR_close
81 36 MA1599.1 ZNF682 MA1599.1 BVGGCYAAGCCCCWNY ZNF682 1.43e-19 1.25e-21 4620 64.8 45100 58.9 1.1 ESR_close
82 37 MA0036.3 GATA2 MA0036.3 NBCTTATCTNH GATA2 2.37e-19 2.04e-21 2480 34.7 22300 29.2 1.19 ESR_close
83 6 MA0738.1 HIC2 MA0738.1 RTGCCCRSB HIC2 2.57e-19 2.18e-21 5610 78.6 56300 73.5 1.07 ESR_close
84 1 MA0796.1 TGIF1 MA0796.1 TGACAGCTGTCA TGIF1 2.61e-19 2.19e-21 240 3.36 1240 1.62 2.09 ESR_close
85 24 MA0633.2 Twist2 MA0633.2 NVCAGCTGBN Twist2 5.47e-19 4.54e-21 1090 15.3 8710 11.4 1.35 ESR_close
86 4 MA1627.1 Wt1 MA1627.1 YBCCTCCCCCACVB Wt1 9.01e-19 7.4e-21 3780 52.9 36000 47 1.13 ESR_close
87 24 MA1631.1 ASCL1 MA1631.1 NNGCACCTGCYNB ASCL1 1.04e-18 8.45e-21 3730 52.2 35500 46.4 1.13 ESR_close
88 24 MA0521.2 Tcf12 MA0521.2 NNACAGCTGTNN Tcf12 2.06e-17 1.66e-19 1370 19.2 11500 15 1.28 ESR_close
89 37 MA0482.2 (GATA4) STREME-5 5-CAGATAAGG CAGATAAGG GATA4 3.9e-17 3.09e-19 469 6.57 3160 4.12 1.6 ESR_close
90 38 MA0734.3 Gli2 MA0734.3 NRGACCACCCASV Gli2 4.12e-17 3.24e-19 6120 85.7 62400 81.4 1.05 ESR_close
91 20 MA1728.1 ZNF549 MA1728.1 NNTGCTGCCCWR ZNF549 5.44e-17 4.18e-19 6160 86.3 63000 82.2 1.05 ESR_close
92 6 MA1528.1 NFIX MA1528.1 STTGGCRNNGTGCCARB NFIX 5.45e-17 4.18e-19 227 3.18 1200 1.57 2.03 ESR_close
93 6 MA0671.1 NFIX MA0671.1 NNTGCCAAN NFIX 5.74e-17 4.36e-19 2550 35.7 23400 30.5 1.17 ESR_close
94 23 MA0807.1 TBX5 MA0807.1 AGGTGTKA TBX5 6.07e-17 4.56e-19 2850 39.9 26500 34.5 1.16 ESR_close
95 23 MA0103.3 ZEB1 MA0103.3 SNCACCTGSVN ZEB1 9.03e-17 6.71e-19 6090 85.3 62200 81.1 1.05 ESR_close
96 34 MA1723.1 PRDM9 MA1723.1 RGDGGGVAGGGRGGVRRMARVARR PRDM9 9.49e-17 6.98e-19 4190 58.6 40700 53.1 1.1 ESR_close
97 24 MA1993.1 Neurod2 MA1993.1 VVCAGCTGBB Neurod2 3.02e-16 2.2e-18 839 11.8 6520 8.5 1.38 ESR_close
98 39 MA1719.1 ZNF816 MA1719.1 DRRKGGGGACATGCHGGG ZNF816 3.34e-16 2.4e-18 4780 66.9 47200 61.6 1.09 ESR_close
99 23 MA0806.1 TBX4 MA0806.1 AGGTGTGA TBX4 3.98e-16 2.84e-18 4770 66.8 47200 61.6 1.09 ESR_close
100 14 MA0124.2 Nkx3-1 MA0124.2 RCCACTTAA Nkx3-1 6.97e-16 4.92e-18 3290 46.1 31200 40.7 1.13 ESR_close
101 50 MA0697.2 Zic3 MA0697.2 CNCAGCAGGAGNN Zic3 1.13e-15 7.88e-18 6460 90.5 66700 87 1.04 ESR_close
102 26 MA0003.4 TFAP2A MA0003.4 NNKGCCTCAGGCNN TFAP2A 1.54e-15 1.07e-17 6570 92 68100 88.8 1.04 ESR_close
103 4 MA1516.1 KLF3 MA1516.1 GRCCRCGCCCH KLF3 1.74e-15 1.19e-17 4480 62.7 44000 57.4 1.09 ESR_close
104 24 MA1652.1 ZKSCAN5 MA1652.1 NNRGGARGTGAGRR ZKSCAN5 2.36e-15 1.6e-17 6150 86.2 63000 82.2 1.05 ESR_close
105 14 MA1994.1 Nkx2-1 MA1994.1 NVCACTTGARHNN Nkx2-1 2.54e-15 1.71e-17 488 6.83 3410 4.44 1.54 ESR_close
106 1 MA0783.1 PKNOX2 MA0783.1 TGACAGGTGTCA PKNOX2 2.93e-15 1.95e-17 191 2.67 980 1.28 2.1 ESR_close
107 40 MA0767.1 GCM2 MA0767.1 BATGCGGGTR GCM2 1.7e-14 1.12e-16 6750 94.6 70400 91.9 1.03 ESR_close
108 41 MA0145.2 Tfcp2l1 MA0145.2 CCAGYYYVADCCRG Tfcp2l1 3.93e-14 2.57e-16 6740 94.4 70300 91.7 1.03 ESR_close
109 23 MA0745.2 SNAI2 MA0745.2 NBGCACCTGTMNY SNAI2 5.8e-14 3.76e-16 6000 84.1 61400 80.1 1.05 ESR_close
110 42 MA1712.1 ZNF454 MA1712.1 DGGCTCSSGGCCCYGVKG ZNF454 7.36e-14 4.73e-16 4550 63.7 45000 58.7 1.09 ESR_close
111 34 MA0471.2 E2F6 MA0471.2 VVDGGCGGGAAVV E2F6 2.51e-13 1.6e-15 6450 90.3 66800 87.1 1.04 ESR_close
112 4 MA1517.1 KLF6 MA1517.1 NRCCACGCCCH KLF6 3.99e-13 2.52e-15 5900 82.6 60200 78.6 1.05 ESR_close
113 24 MA0499.2 MYOD1 MA0499.2 NNGCACCTGTCNB MYOD1 4.07e-13 2.54e-15 4400 61.6 43400 56.6 1.09 ESR_close
114 31 MA1986.1 ZNF692 MA1986.1 BGGGCCCASN ZNF692 6.97e-13 4.31e-15 961 13.5 7910 10.3 1.31 ESR_close
115 1 MA1572.1 TGIF2LY MA1572.1 TGACAGCTGTCA TGIF2LY 8.75e-13 5.38e-15 2850 39.9 27000 35.2 1.14 ESR_close
116 43 MA0751.1 ZIC4 MA0751.1 GRCCCCCCGCKGYGH ZIC4 1.38e-12 8.43e-15 5260 73.6 53000 69.2 1.06 ESR_close
117 28 MA0504.1 NR2C2 MA0504.1 VGRGGTCARAGGTCA NR2C2 2.07e-12 1.25e-14 3150 44.1 30100 39.3 1.12 ESR_close
118 18 MA0812.1 TFAP2B MA0812.1 HGCCTSAGGCD TFAP2B 2.15e-12 1.29e-14 4650 65.1 46300 60.4 1.08 ESR_close
119 24 MA1641.1 MYF5 MA1641.1 NVACAGCTGTBN MYF5 9.78e-12 5.8e-14 2410 33.8 22500 29.4 1.15 ESR_close
120 24 MA0048.2 NHLH1 MA0048.2 CGCAGCTGCK NHLH1 1.46e-11 8.6e-14 1820 25.5 16500 21.5 1.18 ESR_close
121 23 MA1620.1 Ptf1A MA1620.1 NVACACCTGTNN Ptf1A 1.53e-11 8.92e-14 5590 78.3 56900 74.2 1.05 ESR_close
122 44 MA1976.1 ZNF320 MA1976.1 DGKGGGRCCMRGGGGCCWGTGHVNNNN ZNF320 2.2e-11 1.27e-13 3620 50.6 35200 46 1.1 ESR_close
123 34 MA1987.1 ZNF701 MA1987.1 GAGCACYAARGGGGGRADDDD ZNF701 3.71e-11 2.13e-13 5160 72.3 52100 68 1.06 ESR_close
124 24 MA1472.2 Bhlha15 MA1472.2 NVACAGCTGTBN Bhlha15 4.55e-11 2.58e-13 1850 25.9 16900 22 1.18 ESR_close
125 28 MA0258.2 ESR2 MA0258.2 AGGTCASVNTGMCCY ESR2 4.56e-11 2.58e-13 4490 62.9 44700 58.4 1.08 ESR_close
126 45 MA1979.1 ZNF416 MA1979.1 TATCTGGGCAH ZNF416 5.73e-11 3.21e-13 5970 83.6 61400 80.1 1.04 ESR_close
127 24 MA2002.1 Zfp335 MA2002.1 VNTCAGGCANH Zfp335 1.05e-10 5.86e-13 1910 26.8 17500 22.9 1.17 ESR_close
128 23 MA0801.1 MGA MA0801.1 AGGTGTGA MGA 1.64e-10 9.04e-13 4360 61.1 43400 56.7 1.08 ESR_close
129 23 MA1558.1 SNAI1 MA1558.1 DRCAGGTGYD SNAI1 1.66e-10 9.04e-13 4750 66.5 47700 62.2 1.07 ESR_close
130 24 MA0500.2 MYOG MA0500.2 NDRCAGCTGYHN MYOG 1.66e-10 9.04e-13 981 13.7 8300 10.8 1.27 ESR_close
131 23 MA1567.2 Tbx6 MA1567.2 NRGGTGTGAANN Tbx6 2.11e-10 1.14e-12 1760 24.7 16100 21 1.18 ESR_close
132 46 MA0595.1 SREBF1 MA0595.1 VTCACCCCAY SREBF1 2.35e-10 1.25e-12 1380 19.3 12200 15.9 1.21 ESR_close
133 47 14-CTTATAGATAAAA STREME-14 14-CTTATAGATAAAA 14-CTTATAGATAAAA CTTATAGATAAAA 3.18e-10 1.69e-12 20 0.28 15 0.02 14.1 ESR_close
134 48 MA0691.1 TFAP4 MA0691.1 AWCAGCTGWT TFAP4 3.86e-10 2.04e-12 675 9.45 5410 7.06 1.34 ESR_close
135 50 MA1629.1 Zic2 MA1629.1 NDCACAGCAGGDRG Zic2 4.27e-10 2.23e-12 6680 93.6 69900 91.2 1.03 ESR_close
136 30 MA0733.1 EGR4 MA0733.1 NHMCGCCCACGCAHWT EGR4 6.61e-10 3.43e-12 4830 67.6 48600 63.4 1.07 ESR_close
137 30 MA1656.1 ZNF449 MA1656.1 NNAAGCCCAACCNN ZNF449 1.04e-09 5.36e-12 5850 81.9 60100 78.4 1.04 ESR_close
138 49 MA0092.1 Hand1::Tcf3 MA0092.1 BRTCTGGMWT Hand1::Tcf3 1.47e-09 7.53e-12 6930 97.1 73100 95.4 1.02 ESR_close
139 24 MA1109.1 NEUROD1 MA1109.1 NRACAGATGGYNN NEUROD1 1.51e-09 7.69e-12 6060 84.9 62600 81.7 1.04 ESR_close
140 50 MA0697.2 (Zic3) STREME-15 15-CAGCAGG 15-CAGCAGG Zic3 1.62e-09 8.15e-12 7050 98.7 74700 97.4 1.01 ESR_close
141 51 MA1972.1 ZFP14 MA1972.1 GGAGGCHCHGGARBG ZFP14 2.15e-09 1.08e-11 5100 71.4 51700 67.5 1.06 ESR_close
142 52 MA1153.1 Smad4 MA1153.1 TGTCTRGM Smad4 5.78e-09 2.87e-11 1430 20 12800 16.8 1.19 ESR_close
143 1 MA0782.2 PKNOX1 MA0782.2 NNTGAGTGACAGVNN PKNOX1 7.92e-09 3.91e-11 537 7.52 4220 5.51 1.37 ESR_close
144 24 MA1559.1 SNAI3 MA1559.1 RRCAGGTGYA SNAI3 1.58e-08 7.73e-11 4200 58.9 42000 54.8 1.07 ESR_close
145 23 MA0805.1 TBX1 MA0805.1 AGGTGTGA TBX1 2.71e-08 1.32e-10 2140 29.9 20200 26.3 1.14 ESR_close
146 37 MA0482.2 GATA4 MA0482.2 NNCCTTATCTNH GATA4 2.79e-08 1.35e-10 1090 15.3 9620 12.6 1.22 ESR_close
147 37 MA1970.1 TRPS1 MA1970.1 NHTCTTATCTNH TRPS1 3e-08 1.44e-10 2140 30 20200 26.3 1.14 ESR_close
148 37 MA0037.4 Gata3 MA0037.4 NHTCTTATCTNH Gata3 3.79e-08 1.81e-10 880 12.3 7540 9.84 1.25 ESR_close
149 53 MA1600.1 ZNF684 MA1600.1 RYACAGTCCACCCCTTKR ZNF684 5.73e-08 2.72e-10 1930 27.1 18100 23.6 1.15 ESR_close
150 54 MA0084.1 SRY MA0084.1 NWWAACAAT SRY 5.87e-08 2.77e-10 6490 90.9 67800 88.5 1.03 ESR_close
151 23 MA1566.2 TBX3 MA1566.2 RAGGTGTGAAV TBX3 6.16e-08 2.88e-10 4740 66.3 47900 62.5 1.06 ESR_close
152 26 MA0750.2 ZBTB7A MA0750.2 NVCCGGAAGTGSV ZBTB7A 9.32e-08 4.33e-10 6700 93.8 70300 91.8 1.02 ESR_close
153 38 MA1990.1 Gli1 MA1990.1 NNRGACCACCCASV Gli1 1.28e-07 5.89e-10 6350 89 66200 86.4 1.03 ESR_close
154 26 MA1581.1 ZBTB6 MA1581.1 DNSCTTGAGCCNV ZBTB6 1.49e-07 6.84e-10 6750 94.5 70900 92.5 1.02 ESR_close
155 37 MA1104.2 GATA6 MA1104.2 HWWTCTTATCTNH GATA6 1.67e-07 7.59e-10 2080 29.1 19600 25.6 1.13 ESR_close
156 6 MA1527.1 NFIC MA1527.1 NTTGGCDNNRTGCCARN NFIC 2.52e-07 1.14e-09 146 2.04 865 1.13 1.82 ESR_close
157 24 MA1100.2 ASCL1 MA1100.2 VGCAGCTGCN ASCL1 2.9e-07 1.31e-09 6980 97.8 73900 96.4 1.01 ESR_close
158 55 MA0831.3 TFE3 MA0831.3 GTCACGTGAC TFE3 3.5e-07 1.57e-09 1430 20 13100 17 1.17 ESR_close
159 56 MA1726.1 ZNF331 MA1726.1 NMYTGCAGAGCCCH ZNF331 3.8e-07 1.69e-09 6100 85.4 63300 82.6 1.03 ESR_close
160 6 MA0161.2 NFIC MA0161.2 NNCTTGGCANN NFIC 7.05e-07 3.11e-09 1920 26.8 18100 23.6 1.14 ESR_close
161 23 MA0690.2 TBX21 MA0690.2 TTTCACACCTT TBX21 9.44e-07 4.14e-09 3990 55.9 40000 52.2 1.07 ESR_close
162 57 MA1596.1 ZNF460 MA1596.1 GCCTCMGCCTCCCRAG ZNF460 1.04e-06 4.53e-09 2960 41.4 29000 37.8 1.1 ESR_close
163 24 MA0820.1 FIGLA MA0820.1 WMCACCTGKW FIGLA 2.73e-06 1.18e-08 4690 65.7 47700 62.2 1.06 ESR_close
164 24 MA0626.1 Npas2 MA0626.1 NSCACGTGTN Npas2 4.49e-06 1.93e-08 1570 21.9 14600 19.1 1.15 ESR_close
165 58 MA0059.1 (MAX::MYC) STREME-12 12-ACAGAGCACCTGG 12-ACAGAGCACCTGG MAX::MYC 5.41e-06 2.32e-08 13 0.18 10 0.01 13.7 ESR_close
166 48 MA1570.1 TFAP4 MA1570.1 AHCATRTGDT TFAP4 5.81e-06 2.47e-08 4240 59.4 42900 55.9 1.06 ESR_close
167 24 MA0147.3 MYC MA0147.3 NNCCACGTGCNB MYC 7.4e-06 3.13e-08 5960 83.4 61900 80.7 1.03 ESR_close
168 37 MA0140.2 GATA1::TAL1 MA0140.2 MTTATCWSNNNNNHVCAG GATA1::TAL1 1.66e-05 6.96e-08 1830 25.6 17400 22.7 1.13 ESR_close
169 49 MA1964.1 SMAD2 MA1964.1 NBCCAGACDN SMAD2 2.09e-05 8.73e-08 1170 16.4 10700 14 1.17 ESR_close
170 33 MA0130.1 ZNF354C MA0130.1 MTCCAC ZNF354C 2.44e-05 1.01e-07 2390 33.5 23300 30.3 1.1 ESR_close
171 59 MA1644.1 NFYC MA1644.1 RDCCAATCASN NFYC 4.28e-05 1.77e-07 2310 32.4 22500 29.4 1.1 ESR_close
172 60 MA0018.4 CREB1 MA0018.4 NNRTGATGTCAYN CREB1 0.000114 4.67e-07 1370 19.1 12800 16.7 1.15 ESR_close
173 24 MA0093.3 USF1 MA0093.3 NDGTCATGTGACHN USF1 0.000162 6.59e-07 1080 15.1 9920 12.9 1.17 ESR_close
174 46 MA0596.1 SREBF2 MA0596.1 RTGGGGTGAY SREBF2 0.000184 7.45e-07 373 5.22 3020 3.94 1.33 ESR_close
175 28 MA0159.1 RARA::RXRA MA0159.1 RGKTCANVGRSAGGTCA RARA::RXRA 0.00019 7.67e-07 3220 45.1 32200 42 1.07 ESR_close
176 61 MA1982.1 ZNF574 MA1982.1 VGSCTAGAGMGGCCS ZNF574 0.000193 7.73e-07 4580 64.2 46900 61.1 1.05 ESR_close
177 62 MA0748.2 YY2 MA0748.2 NVATGGCGGCS YY2 0.000253 1.01e-06 5930 83 61800 80.6 1.03 ESR_close
178 40 MA0646.1 GCM1 MA0646.1 BATGCGGGTAC GCM1 0.000367 1.46e-06 5460 76.5 56600 73.8 1.04 ESR_close
179 15 MA0736.1 GLIS2 MA0736.1 GACCCCCCGCRAMG GLIS2 0.000424 1.67e-06 2580 36.1 25400 33.2 1.09 ESR_close
180 63 MA0065.2 Pparg::Rxra MA0065.2 STRGGGCARAGGKCA Pparg::Rxra 0.000435 1.71e-06 4380 61.4 44700 58.4 1.05 ESR_close
181 24 MA1619.1 Ptf1A MA1619.1 NNACAGCTGTNN Ptf1A 0.00049 1.91e-06 2630 36.8 26000 34 1.09 ESR_close
182 59 MA1645.1 NKX2-2 MA1645.1 NNNCCACTCAANNN NKX2-2 0.000635 2.47e-06 4920 68.9 50700 66.1 1.04 ESR_close
183 24 MA0104.4 MYCN MA0104.4 VVCCACGTGGBB MYCN 0.00108 4.15e-06 5320 74.5 55100 71.9 1.04 ESR_close
184 24 MA0698.1 ZBTB18 MA0698.1 NATCCAGATGTKB ZBTB18 0.00118 4.53e-06 3210 44.9 32200 42 1.07 ESR_close
185 24 MA0692.1 TFEB MA0692.1 RYCACGTGAC TFEB 0.00125 4.76e-06 1310 18.3 12400 16.2 1.14 ESR_close
186 18 MA0813.1 TFAP2B MA0813.1 TGCCCYBRGGGCA TFAP2B 0.00161 6.1e-06 1670 23.4 16100 21.1 1.11 ESR_close
187 64 17-CTCTGAAGAGAGCAG STREME-17 17-CTCTGAAGAGAGCAG 17-CTCTGAAGAGAGCAG CTCTGAAGAGAGCAG 0.00192 7.26e-06 84 1.18 503 0.66 1.81 ESR_close
188 23 MA0688.1 TBX2 MA0688.1 DAGGTGTGAAA TBX2 0.00199 7.47e-06 1260 17.6 11900 15.5 1.14 ESR_close
189 28 MA0014.3 PAX5 MA0014.3 RRGCGTGACCNN PAX5 0.00245 9.16e-06 6400 89.6 67300 87.8 1.02 ESR_close
190 65 MA0879.2 DLX1 MA0879.2 VYAATTAN DLX1 0.00361 1.34e-05 6790 95 71800 93.8 1.01 ESR_close
191 66 MA1122.1 TFDP1 MA1122.1 VSGCGGGAAVN TFDP1 0.00398 1.47e-05 4510 63.2 46400 60.5 1.04 ESR_close
192 67 MA1721.1 ZNF93 MA1721.1 GGYAGCRGCAGCGGYG ZNF93 0.00406 1.49e-05 3710 52 37700 49.2 1.06 ESR_close
193 66 MA0865.2 E2F8 MA0865.2 TTCCCGCCAHWA E2F8 0.00415 1.52e-05 6280 87.9 65900 86 1.02 ESR_close
194 23 MA1565.1 TBX18 MA1565.1 DRAGGTGTGAAR TBX18 0.00784 2.85e-05 3810 53.4 38900 50.7 1.05 ESR_close
195 1 MA1114.1 PBX3 MA1114.1 NNNTGAGTGACAGGBNN PBX3 0.0082 2.97e-05 129 1.81 905 1.18 1.54 ESR_close
196 48 MA1593.1 ZNF317 MA1593.1 WVACAGCAGAYW ZNF317 0.00898 3.24e-05 317 4.44 2630 3.43 1.3 ESR_close
197 65 MA0914.1 ISL2 MA0914.1 GCAMTTAR ISL2 0.0107 3.85e-05 619 8.67 5570 7.27 1.19 ESR_close
198 18 MA0872.1 TFAP2A MA0872.1 TGCCCYSRGGGCA TFAP2A 0.0111 3.96e-05 1750 24.4 17100 22.2 1.1 ESR_close
199 23 MA1621.1 Rbpjl MA1621.1 NNVACACCTGTBNN Rbpjl 0.0115 4.09e-05 4500 63 46300 60.5 1.04 ESR_close
200 18 MA0815.1 TFAP2C MA0815.1 TGCCCYSRGGGCA TFAP2C 0.0131 4.64e-05 1630 22.9 15900 20.7 1.1 ESR_close
201 28 MA0730.1 RARA MA0730.1 AGGTCAHSYAAAGGTCA RARA 0.0137 4.82e-05 106 1.48 718 0.94 1.6 ESR_close
202 39 MA0056.2 MZF1 MA0056.2 NNAATCCCCANNN MZF1 0.0153 5.36e-05 5800 81.2 60700 79.2 1.03 ESR_close
203 66 MA1116.1 RBPJ MA1116.1 BVTGGGAANN RBPJ 0.0163 5.66e-05 982 13.8 9240 12 1.14 ESR_close
204 68 MA0808.1 TEAD3 MA0808.1 RCATTCCW TEAD3 0.0195 6.74e-05 3670 51.3 37400 48.8 1.05 ESR_close
205 54 MA0077.1 SOX9 MA0077.1 CYATTGTTY SOX9 0.0229 7.89e-05 6860 96 72800 94.9 1.01 ESR_close
206 65 MA0881.1 Dlx4 MA0881.1 VYAATTAN Dlx4 0.0294 0.000101 6900 96.6 73300 95.6 1.01 ESR_close
207 59 MA0060.3 NFYA MA0060.3 RRCCAATCAGM NFYA 0.0301 0.000103 5010 70.1 52000 67.8 1.03 ESR_close
208 65 MA0880.1 Dlx3 MA0880.1 NYAATTAN Dlx3 0.0377 0.000128 6950 97.4 74000 96.5 1.01 ESR_close
209 48 MA1468.1 ATOH7 MA1468.1 AVCATATGBY ATOH7 0.0407 0.000137 6420 89.9 67700 88.3 1.02 ESR_close
210 48 MA1730.1 ZNF708 MA1730.1 NNRGCTGTRCCTCCY ZNF708 0.043 0.000144 5340 74.8 55700 72.6 1.03 ESR_close
211 69 MA0131.2 HINFP MA0131.2 CARCGTCCGCKN HINFP 0.0488 0.000163 3990 55.9 41000 53.5 1.04 ESR_close
24 70 MA1731.1 (ZNF768) MEME-8 WCTYTCTCTCTCTCT WCTYTCTCTCTCTCT ZNF768 0.456 0.019 312 4.37 2950 3.85 1.14 ESR_close
25 71 MA1107.2 (KLF9) MEME-7 TGTGTGTGTGTGTGT TGTGTGTGTGTGTGT KLF9 1.16 0.0462 846 11.8 8560 11.2 1.06 ESR_close
26 72 MA1125.1 (ZNF384) MEME-4 AAAAAAAAAAAAAAA AAAAAAAAAAAAAAA ZNF384 18.7 0.72 47 0.66 546 0.71 0.942 ESR_close 
ER_rat <- 1.25
mrc_type <- "ESR_close"
ESR_close_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

ESR_close_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.75), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.75,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

ESR_opcl data

ESR_opcl_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_opcl_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
ESR_opcl_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_opcl_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
ESR_opcl_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_opcl_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
ESR_opcl_sea_all <- rbind(ESR_opcl_sea_disc, ESR_opcl_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)
ESR_opcl_combo <- ESR_opcl_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., ESR_opcl_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="ESR_opcl")

ESR_opcl_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")
Enriched motifs 200 bp in EAR open v NR
RANK CLUSTER SIM_MOTIF ALT_ID ID CONSENSUS.x motif_name EVALUE.y QVALUE TP TP. FP FP. ENR_RATIO mrc_type
1 1 MA0808.1 (TEAD3) MEME-1 TGGAATKY TGGAATKY TEAD3 7.39e-12 5.4e-12 76 41.5 13100 17.1 2.44 ESR_opcl
2 2 MA1580.1 (ZBTB32) STREME-2 2-TACAGT TACAGT ZBTB32 4.25e-08 1.12e-08 165 90.2 53600 70 1.29 ESR_opcl
3 3 MA0905.1 HOXC10 MA0905.1 GTCRTAAAAH HOXC10 4.61e-08 1.12e-08 154 84.2 47600 62.1 1.36 ESR_opcl
4 4 5-ATTAGAA STREME-5 5-ATTAGAA ATTAGAA ATTAGAA 5.33e-07 8.69e-08 165 90.2 54800 71.4 1.26 ESR_opcl
5 1 MA0090.3 (TEAD1) STREME-3 3-ATTCCATAM ATTCCATAM TEAD1 5.94e-07 8.69e-08 149 81.4 46200 60.3 1.35 ESR_opcl
6 5 MA1471.1 BARX2 MA1471.1 NWWAAYMATTAN BARX2 8.16e-07 9.94e-08 152 83.1 47900 62.5 1.33 ESR_opcl
7 3 MA0913.2 HOXD9 MA0913.2 GYMATAAAAH HOXD9 2.72e-06 2.85e-07 121 66.1 34100 44.5 1.49 ESR_opcl
8 1 MA0809.2 TEAD4 MA0809.2 NNACATTCCARN TEAD4 1e-05 9.18e-07 89 48.6 22000 28.8 1.7 ESR_opcl
9 6 MA0052.4 MEF2A MA0052.4 DDCTAAAAATAGMHH MEF2A 2.21e-05 1.79e-06 162 88.5 54800 71.5 1.24 ESR_opcl
10 7 MA0788.1 POU3F3 MA0788.1 WWTATGCWAATTW POU3F3 3.81e-05 2.6e-06 135 73.8 41600 54.3 1.36 ESR_opcl
11 8 MA0718.1 RAX MA0718.1 RYYAATTARH RAX 3.91e-05 2.6e-06 165 90.2 56800 74.1 1.22 ESR_opcl
12 3 MA0899.1 HOXA10 MA0899.1 DGYMATAAAAH HOXA10 8.09e-05 4.93e-06 165 90.2 57100 74.6 1.21 ESR_opcl
13 1 MA0090.3 TEAD1 MA0090.3 NNACATTCCAGSN TEAD1 0.000122 6.88e-06 66 36.1 15000 19.6 1.86 ESR_opcl
14 9 MA0766.2 GATA5 MA0766.2 SWGATAASRN GATA5 0.000146 7.61e-06 123 67.2 37000 48.2 1.4 ESR_opcl
15 3 MA0907.1 HOXC13 MA0907.1 BCTCGTAAAAH HOXC13 0.000244 1.12e-05 106 57.9 30100 39.3 1.48 ESR_opcl
16 8 MA0601.1 Arid3b MA0601.1 ATATTAATWAN Arid3b 0.000244 1.12e-05 140 76.5 44900 58.6 1.31 ESR_opcl
17 10 MA0901.2 HOXB13 MA0901.2 WDCCAATAAAAWWW HOXB13 0.000322 1.38e-05 154 84.2 51900 67.8 1.24 ESR_opcl
18 11 MA0108.2 TBP MA0108.2 STATAAAWRSVVVBN TBP 0.000402 1.63e-05 113 61.8 33300 43.4 1.43 ESR_opcl
6 23 4-VWWDTAHWWB STREME-4 4-VWWDTAHWWB VWWDTAHWWB VWWDTAHWWB 0.000454 7.56e-05 73 39.9 20500 26.7 1.5 ESR_opcl
19 12 MA0624.2 Nfatc1 MA0624.2 NVATGGAAAAWN Nfatc1 0.000513 1.97e-05 136 74.3 43500 56.7 1.31 ESR_opcl
20 5 MA0724.1 VENTX MA0724.1 AMCGATTAR VENTX 0.000628 2.3e-05 135 73.8 43100 56.3 1.31 ESR_opcl
21 13 MA0033.2 FOXL1 MA0033.2 RTAAACA FOXL1 0.000806 2.81e-05 153 83.6 51900 67.8 1.24 ESR_opcl
22 13 MA0845.1 FOXB1 MA0845.1 WATGTAAATAT FOXB1 0.000905 3.01e-05 140 76.5 45700 59.6 1.29 ESR_opcl
23 10 MA0465.2 CDX2 MA0465.2 NDGCAATAAAWN CDX2 0.000978 3.11e-05 154 84.2 52500 68.6 1.23 ESR_opcl
24 10 MA0650.3 Hoxa13 MA0650.3 NNCCAATAAAAN Hoxa13 0.00112 3.33e-05 158 86.3 54700 71.4 1.21 ESR_opcl
25 14 MA0602.1 Arid5a MA0602.1 SYAATATTGVDANH Arid5a 0.00114 3.33e-05 133 72.7 42600 55.5 1.31 ESR_opcl
26 13 MA0848.1 FOXO4 MA0848.1 GTAAACA FOXO4 0.00177 4.99e-05 164 89.6 58200 75.9 1.18 ESR_opcl
27 15 MA1974.1 ZNF211 MA1974.1 HWYATATACCAYRYW ZNF211 0.00189 5.13e-05 107 58.5 31700 41.3 1.42 ESR_opcl
28 13 MA0614.1 Foxj2 MA0614.1 RTAAACAA Foxj2 0.00198 5.18e-05 121 66.1 37600 49 1.35 ESR_opcl
29 8 MA0713.1 PHOX2A MA0713.1 TAATYYAATTA PHOX2A 0.00238 6.01e-05 151 82.5 51500 67.3 1.23 ESR_opcl
30 13 MA0032.2 FOXC1 MA0032.2 WAWGTAAAYAW FOXC1 0.00266 6.48e-05 135 73.8 44000 57.4 1.29 ESR_opcl
31 16 MA0151.1 Arid3a MA0151.1 ATYAAA Arid3a 0.00282 6.66e-05 117 63.9 36100 47.1 1.36 ESR_opcl
32 10 MA1963.1 SATB1 MA1963.1 WWDCTAATAAHWW SATB1 0.00371 8.47e-05 128 70 41000 53.5 1.31 ESR_opcl
33 8 MA0681.2 PHOX2B MA0681.2 WWTAATCAAATTAWWW PHOX2B 0.0039 8.64e-05 133 72.7 43300 56.5 1.29 ESR_opcl
34 8 MA0634.1 ALX3 MA0634.1 YYYAATTANV ALX3 0.00461 9.91e-05 150 82 51400 67.1 1.22 ESR_opcl
35 8 MA0122.3 Nkx3-2 MA0122.3 WWAAMCACTTAAN Nkx3-2 0.00505 0.000105 91 49.7 25800 33.7 1.48 ESR_opcl
36 17 MA1120.1 SOX13 MA1120.1 DVACAATGGNN SOX13 0.00567 0.000115 163 89.1 58300 76.1 1.17 ESR_opcl
37 5 MA0723.2 VAX2 MA0723.2 BYAATTAV VAX2 0.00596 0.000118 156 85.2 54600 71.3 1.2 ESR_opcl
38 8 MA0635.1 BARHL2 MA0635.1 VHTAAAYGRT BARHL2 0.00619 0.000119 166 90.7 60000 78.3 1.16 ESR_opcl
39 13 MA0846.1 FOXC2 MA0846.1 WAWGTAAACAWW FOXC2 0.00686 0.000129 165 90.2 59500 77.6 1.16 ESR_opcl
40 13 MA1606.1 Foxf1 MA1606.1 DWRTAAACANN Foxf1 0.00713 0.00013 133 72.7 43700 57 1.28 ESR_opcl
41 8 MA0654.1 ISX MA0654.1 YYAATTAR ISX 0.00808 0.000144 135 73.8 44700 58.3 1.27 ESR_opcl
42 8 MA0793.1 POU6F2 MA0793.1 ASCTMATTAW POU6F2 0.00835 0.000145 148 80.9 50800 66.3 1.22 ESR_opcl
43 13 MA1683.1 FOXA3 MA1683.1 DWGTAAACANN FOXA3 0.0118 2e-04 117 63.9 37000 48.2 1.33 ESR_opcl
44 13 MA1487.2 FOXE1 MA1487.2 VYTAAAYAAACAAH FOXE1 0.0133 0.000221 114 62.3 35800 46.7 1.34 ESR_opcl
45 5 MA0903.1 HOXB3 MA0903.1 NNYMATTARN HOXB3 0.0143 0.000231 171 93.4 63400 82.7 1.13 ESR_opcl
46 13 MA1103.2 FOXK2 MA1103.2 DDGTAAACANN FOXK2 0.0145 0.000231 101 55.2 30400 39.7 1.4 ESR_opcl
47 18 MA0523.1 TCF7L2 MA0523.1 DRASATCAAAGRVA TCF7L2 0.0184 0.000287 131 71.6 43400 56.6 1.27 ESR_opcl
48 19 MA0144.2 STAT3 MA0144.2 YTTCYKGGAAD STAT3 0.0223 0.000339 120 65.6 38700 50.5 1.3 ESR_opcl
49 20 MA0676.1 Nr2e1 MA0676.1 AAAAGTCAA Nr2e1 0.0234 0.000349 160 87.4 57500 75.1 1.17 ESR_opcl
50 21 MA1707.1 DMRTA1 MA1707.1 AWTTGWTACAWT DMRTA1 0.0247 0.000357 54 29.5 13200 17.2 1.74 ESR_opcl
51 8 MA0874.1 Arx MA0874.1 VTBCRYTAATTARTKSW Arx 0.0253 0.000357 79 43.2 22200 28.9 1.5 ESR_opcl
52 17 MA0514.2 Sox3 MA0514.2 DNACAATGGNN Sox3 0.0257 0.000357 127 69.4 41800 54.6 1.27 ESR_opcl
53 22 1-MAWWTK STREME-1 1-MAWWTK MAWWTK MAWWTK 0.0259 0.000357 102 55.7 31200 40.7 1.37 ESR_opcl
54 17 MA1603.1 Dmrt1 MA1603.1 GHTACAAAGTADC Dmrt1 0.029 0.000392 110 60.1 34600 45.1 1.34 ESR_opcl
55 7 MA0792.1 POU5F1B MA0792.1 TATGCWAAT POU5F1B 0.0307 0.000408 88 48.1 25700 33.6 1.44 ESR_opcl
56 12 MA0606.2 Nfat5 MA0606.2 NNATGGAAAAWN Nfat5 0.0319 0.000417 114 62.3 36300 47.4 1.32 ESR_opcl
57 13 MA0851.1 Foxj3 MA0851.1 NDAADGTAAACAAANNM Foxj3 0.0331 0.000424 124 67.8 40700 53.1 1.28 ESR_opcl
58 9 MA0035.4 GATA1 MA0035.4 NHCTAATCTDH GATA1 0.0369 0.000465 98 53.6 29800 38.9 1.38 ESR_opcl
59 8 MA0125.1 Nobox MA0125.1 TAATTRSY Nobox 0.0394 0.000489 161 88 58400 76.2 1.16 ESR_opcl
60 8 MA0712.2 OTX2 MA0712.2 NDRGGATTARNN OTX2 0.043 0.000523 170 92.9 63400 82.7 1.12 ESR_opcl
61 8 MA0708.2 MSX2 MA0708.2 SCAATTAV MSX2 0.0454 0.000544 146 79.8 51000 66.5 1.2 ESR_opcl
62 8 MA1505.1 HOXC8 MA1505.1 KTAATTAM HOXC8 0.0463 0.000545 156 85.2 55900 73 1.17 ESR_opcl
63 5 MA0675.1 NKX6-2 MA0675.1 NYMATTAA NKX6-2 0.047 0.000545 142 77.6 49100 64 1.21 ESR_opcl 
ER_rat <- 1.25
mrc_type <- "ESR_opcl"
ESR_opcl_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

ESR_opcl_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*.1), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.1,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

ESR_clop data

ESR_clop_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_clop_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
ESR_clop_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_clop_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
ESR_clop_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_clop_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
ESR_clop_sea_all <- rbind(ESR_clop_sea_disc, ESR_clop_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)
ESR_clop_combo <- ESR_clop_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., ESR_clop_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="ESR_clop")

ESR_clop_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")
Enriched motifs 200 bp in EAR open v NR
RANK CLUSTER SIM_MOTIF ALT_ID ID CONSENSUS.x motif_name EVALUE.y QVALUE TP TP. FP FP. ENR_RATIO mrc_type
1 1 MA1138.1 (FOSL2::JUNB) MEME-1 TGASTCAT TGASTCAT FOSL2::JUNB 6.64e-111 3.58e-111 342 53.2 11200 14.6 3.64 ESR_clop
2 1 MA1134.1 (FOS::JUNB) STREME-1 1-DVTGASTCABH DVTGASTCABH FOS::JUNB 1.11e-108 3e-109 321 49.9 9920 12.9 3.86 ESR_clop
3 1 MA0476.1 FOS MA0476.1 DVTGASTCATB FOS 4.53e-106 8.14e-107 308 47.9 9250 12.1 3.98 ESR_clop
4 1 MA0099.3 FOS::JUN MA0099.3 ATGAGTCAYM FOS::JUN 7.21e-100 9.73e-101 325 50.5 11000 14.4 3.53 ESR_clop
5 1 MA1134.1 FOS::JUNB MA1134.1 KATGASTCATHN FOS::JUNB 6.71e-97 7.23e-98 327 50.9 11400 14.9 3.41 ESR_clop
6 1 MA1130.1 FOSL2::JUN MA1130.1 NNRTGAGTCAYN FOSL2::JUN 6.26e-96 5.63e-97 312 48.5 10400 13.6 3.57 ESR_clop
7 1 MA0477.2 FOSL1 MA0477.2 NNATGACTCATNN FOSL1 9.26e-96 7.13e-97 283 44 8440 11 4 ESR_clop
8 1 MA0489.2 Jun MA0489.2 NVTGACTCATNN Jun 1.09e-95 7.34e-97 296 46 9320 12.2 3.79 ESR_clop
9 1 MA1634.1 BATF MA1634.1 DATGACTCATH BATF 1.5e-95 8.96e-97 288 44.8 8790 11.5 3.91 ESR_clop
10 1 MA1141.1 FOS::JUND MA1141.1 NKATGAGTCATNN FOS::JUND 2.34e-95 1.26e-96 319 49.6 11000 14.3 3.47 ESR_clop
11 1 MA0462.2 BATF::JUN MA0462.2 DATGACTCATH BATF::JUN 9.45e-95 4.64e-96 309 48.1 10300 13.5 3.58 ESR_clop
12 1 MA1128.1 FOSL1::JUN MA1128.1 NKATGACTCATNN FOSL1::JUN 2.03e-93 9.11e-95 309 48.1 10400 13.6 3.53 ESR_clop
13 1 MA1633.2 BACH1 MA1633.2 ATGACTCAT BACH1 5.96e-93 2.47e-94 287 44.6 8950 11.7 3.83 ESR_clop
14 1 MA0490.2 JUNB MA0490.2 NNATGACTCATNN JUNB 2.88e-92 1.11e-93 319 49.6 11300 14.7 3.37 ESR_clop
15 1 MA0478.1 FOSL2 MA0478.1 KRRTGASTCAB FOSL2 1.4e-91 5.03e-93 275 42.8 8260 10.8 3.97 ESR_clop
16 1 MA1144.1 FOSL2::JUND MA1144.1 KATGACTCAT FOSL2::JUND 1.01e-90 3.42e-92 272 42.3 8140 10.6 3.99 ESR_clop
17 1 MA1137.1 FOSL1::JUNB MA1137.1 NDRTGACTCATNN FOSL1::JUNB 1.57e-90 4.98e-92 358 55.7 14600 19 2.93 ESR_clop
18 1 MA1135.1 FOSB::JUNB MA1135.1 KRTGASTCAT FOSB::JUNB 3.54e-90 1.06e-91 267 41.5 7860 10.3 4.06 ESR_clop
19 1 MA1928.1 BNC2 MA1928.1 NDRTGAGTCABN BNC2 1.72e-88 4.87e-90 390 60.6 17700 23 2.63 ESR_clop
20 1 MA0491.2 JUND MA0491.2 NNATGACTCATNN JUND 8.49e-88 2.29e-89 269 41.8 8190 10.7 3.92 ESR_clop
21 1 MA0655.1 JDP2 MA0655.1 ATGACTCAT JDP2 1.19e-85 3.06e-87 385 59.9 17600 22.9 2.61 ESR_clop
22 1 MA0835.2 BATF3 MA0835.2 DATGACTCATH BATF3 4.19e-85 1.03e-86 255 39.7 7510 9.8 4.06 ESR_clop
23 1 MA1101.2 BACH2 MA1101.2 DWANCATGASTCATSNTWH BACH2 2.89e-83 6.77e-85 264 41.1 8260 10.8 3.82 ESR_clop
24 1 MA1132.1 JUN::JUNB MA1132.1 KATGACKCAT JUN::JUNB 1.11e-81 2.5e-83 294 45.7 10500 13.7 3.34 ESR_clop
25 1 MA1138.1 FOSL2::JUNB MA1138.1 KRTGASTCAT FOSL2::JUNB 6.96e-81 1.5e-82 240 37.3 6910 9.02 4.15 ESR_clop
26 1 MA0841.1 NFE2 MA0841.1 VATGACTCATS NFE2 7.34e-80 1.52e-81 296 46 10800 14.2 3.26 ESR_clop
27 1 MA1142.1 FOSL1::JUND MA1142.1 NRTGACTCAT FOSL1::JUND 1.49e-77 2.97e-79 293 45.6 10900 14.2 3.22 ESR_clop
28 1 MA1988.1 Atf3 MA1988.1 NRTGACTCABN Atf3 4.35e-76 8.38e-78 215 33.4 5780 7.54 4.45 ESR_clop
29 1 MA0089.2 MAFG::NFE2L1 MA0089.2 NVNATGACTCAGCADW MAFG::NFE2L1 1.58e-52 2.93e-54 360 56 20300 26.5 2.11 ESR_clop
30 1 MA0501.1 MAF::NFE2 MA0501.1 ATGACTCAGCANWTY MAF::NFE2 1.21e-45 2.17e-47 304 47.3 16200 21.1 2.24 ESR_clop
31 1 MA0150.2 Nfe2l2 MA0150.2 CASNATGACTCAGCA Nfe2l2 8.08e-40 1.41e-41 252 39.2 12600 16.4 2.39 ESR_clop
32 2 MA1970.1 (TRPS1) STREME-2 2-WAGATRABNWA WAGATRABNWA TRPS1 1.26e-38 2.12e-40 344 53.5 21500 28 1.91 ESR_clop
33 1 MA0676.1 (Nr2e1) STREME-3 3-AGTCAW AGTCAW Nr2e1 2.34e-37 3.82e-39 515 80.1 42200 55 1.46 ESR_clop
34 1 MA0659.3 Mafg MA0659.3 NWGMTGACTCAGCAN Mafg 1.52e-34 2.41e-36 161 25 6250 8.16 3.08 ESR_clop
35 1 MA0496.3 MAFK MA0496.3 NGMTGACTCAGCMNH MAFK 6.19e-33 9.53e-35 477 74.2 38300 50 1.49 ESR_clop
36 2 MA1970.1 TRPS1 MA1970.1 NHTCTTATCTNH TRPS1 5.56e-25 8.33e-27 372 57.8 28000 36.5 1.59 ESR_clop
37 2 MA0766.2 GATA5 MA0766.2 SWGATAASRN GATA5 8.37e-24 1.22e-25 334 51.9 24100 31.5 1.65 ESR_clop
38 2 MA0035.4 GATA1 MA0035.4 NHCTAATCTDH GATA1 2.28e-22 3.24e-24 588 91.4 57900 75.6 1.21 ESR_clop
39 3 MA0018.4 (CREB1) STREME-4 4-ACATCA ACATCA CREB1 5.02e-22 6.95e-24 447 69.5 37900 49.4 1.41 ESR_clop
40 4 MA1113.2 PBX2 MA1113.2 NHCATAAATCAHN PBX2 5.22e-22 7.04e-24 513 79.8 46600 60.8 1.31 ESR_clop
41 2 MA0037.4 Gata3 MA0037.4 NHTCTTATCTNH Gata3 5.51e-22 7.25e-24 445 69.2 37600 49.1 1.41 ESR_clop
42 5 MA0886.1 EMX2 MA0886.1 VBTAATTARB EMX2 6.83e-22 8.77e-24 524 81.5 48200 62.9 1.3 ESR_clop
43 6 MA0790.1 POU4F1 MA0790.1 ATGMATAATTAATG POU4F1 3.83e-21 4.81e-23 539 83.8 50600 66 1.27 ESR_clop
44 5 MA0158.2 HOXA5 MA0158.2 GYMATTAS HOXA5 5.5e-21 6.74e-23 411 63.9 33800 44.1 1.45 ESR_clop
45 7 MA1471.1 BARX2 MA1471.1 NWWAAYMATTAN BARX2 7.56e-21 9.06e-23 588 91.4 58400 76.2 1.2 ESR_clop
46 8 MA1978.1 ZNF354A MA1978.1 HWAADWATAAATGRAYWAWTT ZNF354A 9.14e-21 1.07e-22 565 87.9 54700 71.4 1.23 ESR_clop
47 7 MA0680.2 Pax7 MA0680.2 DWTAATCAATTAWNH Pax7 9.41e-21 1.08e-22 483 75.1 42900 56 1.34 ESR_clop
48 2 MA0036.3 GATA2 MA0036.3 NBCTTATCTNH GATA2 1.23e-20 1.39e-22 460 71.5 40000 52.2 1.37 ESR_clop
49 5 MA0661.1 MEOX1 MA0661.1 VSTAATTAHC MEOX1 1.26e-20 1.39e-22 535 83.2 50200 65.5 1.27 ESR_clop
50 5 MA1502.1 HOXB8 MA1502.1 GYMATTAM HOXB8 1.44e-20 1.55e-22 480 74.6 42600 55.6 1.34 ESR_clop
51 9 MA0679.2 ONECUT1 MA0679.2 WAAAAATCAATAAWWN ONECUT1 8.37e-20 8.85e-22 485 75.4 43500 56.8 1.33 ESR_clop
52 5 MA0910.2 HOXD8 MA0910.2 GYMATTAM HOXD8 1.42e-19 1.47e-21 472 73.4 41900 54.7 1.34 ESR_clop
53 10 MA0142.1 Pou5f1::Sox2 MA0142.1 CWTTGTYATGCAAAT Pou5f1::Sox2 1.67e-19 1.7e-21 534 83 50500 65.8 1.26 ESR_clop
54 5 MA0713.1 PHOX2A MA0713.1 TAATYYAATTA PHOX2A 1.76e-19 1.76e-21 550 85.5 52800 68.9 1.24 ESR_clop
55 11 MA1480.1 DPRX MA1480.1 AGATAATCCN DPRX 2.22e-19 2.17e-21 567 88.2 55500 72.4 1.22 ESR_clop
56 5 MA0706.1 MEOX2 MA0706.1 DSTAATTAWN MEOX2 3.73e-19 3.55e-21 592 92.1 59700 77.8 1.18 ESR_clop
57 5 MA0718.1 RAX MA0718.1 RYYAATTARH RAX 3.75e-19 3.55e-21 608 94.6 62500 81.6 1.16 ESR_clop
58 5 MA0628.1 POU6F1 MA0628.1 AYTAATTART POU6F1 5.66e-19 5.27e-21 591 91.9 59500 77.7 1.18 ESR_clop
59 12 MA1606.1 Foxf1 MA1606.1 DWRTAAACANN Foxf1 8.36e-19 7.63e-21 559 86.9 54400 71 1.22 ESR_clop
60 5 MA0902.2 HOXB2 MA0902.2 SYAATTAS HOXB2 8.49e-19 7.63e-21 431 67 37000 48.3 1.39 ESR_clop
61 13 MA0084.1 SRY MA0084.1 NWWAACAAT SRY 1.06e-18 9.37e-21 612 95.2 63400 82.8 1.15 ESR_clop
62 4 MA1640.1 MEIS2 MA1640.1 NNATGATTTATGDNH MEIS2 2.15e-18 1.84e-20 482 75 43700 57 1.32 ESR_clop
63 12 MA1683.1 FOXA3 MA1683.1 DWGTAAACANN FOXA3 2.15e-18 1.84e-20 629 97.8 67100 87.5 1.12 ESR_clop
64 12 MA0148.4 FOXA1 MA0148.4 WWGTAAACATNN FOXA1 2.65e-18 2.24e-20 630 98 67300 87.8 1.12 ESR_clop
65 12 MA1103.2 FOXK2 MA1103.2 DDGTAAACANN FOXK2 4.17e-18 3.46e-20 610 94.9 63200 82.5 1.15 ESR_clop
66 5 MA0681.2 PHOX2B MA0681.2 WWTAATCAAATTAWWW PHOX2B 1.11e-17 9.06e-20 467 72.6 42000 54.8 1.33 ESR_clop
67 5 MA0890.1 GBX2 MA0890.1 RSYAATTARN GBX2 1.42e-17 1.14e-19 574 89.3 57200 74.7 1.2 ESR_clop
68 5 MA0675.1 NKX6-2 MA0675.1 NYMATTAA NKX6-2 1.68e-17 1.33e-19 599 93.2 61400 80.2 1.16 ESR_clop
69 10 MA0786.1 POU3F1 MA0786.1 WTATGCWAATKW POU3F1 2.38e-17 1.86e-19 594 92.4 60600 79.1 1.17 ESR_clop
70 5 MA0658.1 LHX6 MA0658.1 RCTAATTARY LHX6 3.87e-17 2.98e-19 496 77.1 46000 60 1.29 ESR_clop
71 5 MA1495.1 HOXA1 MA1495.1 STAATTAS HOXA1 6.05e-17 4.59e-19 491 76.4 45400 59.3 1.29 ESR_clop
72 6 MA0791.1 POU4F3 MA0791.1 RTGMATWATTAATGAR POU4F3 6.88e-17 5.15e-19 499 77.6 46500 60.7 1.28 ESR_clop
73 5 MA0027.2 EN1 MA0027.2 SYAATTAV EN1 8.18e-17 6.04e-19 596 92.7 61100 79.8 1.16 ESR_clop
74 2 MA1104.2 GATA6 MA1104.2 HWWTCTTATCTNH GATA6 1.02e-16 7.44e-19 596 92.7 61200 79.8 1.16 ESR_clop
75 2 MA0482.2 GATA4 MA0482.2 NNCCTTATCTNH GATA4 1.07e-16 7.71e-19 452 70.3 40400 52.8 1.33 ESR_clop
76 5 MA0793.1 POU6F2 MA0793.1 ASCTMATTAW POU6F2 1.28e-16 9.05e-19 576 89.6 57900 75.5 1.19 ESR_clop
77 5 MA0630.1 SHOX MA0630.1 HTAATTRR SHOX 1.38e-16 9.64e-19 621 96.6 65900 86 1.12 ESR_clop
78 5 MA0723.2 VAX2 MA0723.2 BYAATTAV VAX2 2.24e-16 1.55e-18 551 85.7 54100 70.6 1.21 ESR_clop
79 14 MA0676.1 Nr2e1 MA0676.1 AAAAGTCAA Nr2e1 2.99e-16 2.04e-18 451 70.1 40500 52.8 1.33 ESR_clop
80 5 MA0644.2 ESX1 MA0644.2 YYAATTAN ESX1 3.2e-16 2.16e-18 576 89.6 58000 75.7 1.18 ESR_clop
81 5 MA0648.1 GSC MA0648.1 VYTAATCCSY GSC 1.63e-15 1.09e-17 603 93.8 62800 82 1.14 ESR_clop
82 5 MA0704.1 Lhx4 MA0704.1 YTAATTAR Lhx4 2.85e-15 1.87e-17 549 85.4 54200 70.8 1.21 ESR_clop
83 5 MA0888.1 EVX2 MA0888.1 VVTAATTAVB EVX2 3.03e-15 1.97e-17 510 79.3 48700 63.5 1.25 ESR_clop
84 5 MA0904.2 HOXB5 MA0904.2 STAATTAS HOXB5 5.2e-15 3.34e-17 436 67.8 39100 51 1.33 ESR_clop
85 5 MA0903.1 HOXB3 MA0903.1 NNYMATTARN HOXB3 5.56e-15 3.53e-17 554 86.2 55100 71.9 1.2 ESR_clop
86 5 MA0634.1 ALX3 MA0634.1 YYYAATTANV ALX3 8.74e-15 5.48e-17 623 96.9 66900 87.2 1.11 ESR_clop
87 5 MA0722.1 VAX1 MA0722.1 YTAATTAH VAX1 9.45e-15 5.86e-17 547 85.1 54100 70.6 1.2 ESR_clop
88 5 MA0717.1 RAX2 MA0717.1 YYAATTAV RAX2 1.23e-14 7.53e-17 593 92.2 61400 80.1 1.15 ESR_clop
89 10 MA0787.1 POU3F2 MA0787.1 WTATGCWAATKA POU3F2 1.87e-14 1.13e-16 537 83.5 52800 68.9 1.21 ESR_clop
90 5 MA0674.1 NKX6-1 MA0674.1 NTMATTAA NKX6-1 2.25e-14 1.35e-16 616 95.8 65600 85.6 1.12 ESR_clop
91 5 MA0707.2 MNX1 MA0707.2 VYRATTAK MNX1 2.61e-14 1.52e-16 393 61.1 34100 44.5 1.37 ESR_clop
92 5 MA0721.1 UNCX MA0721.1 YYAATTAV UNCX 2.61e-14 1.52e-16 604 93.9 63400 82.7 1.14 ESR_clop
93 5 MA0612.2 EMX1 MA0612.2 BTAATTAS EMX1 2.62e-14 1.52e-16 370 57.5 31400 41 1.41 ESR_clop
94 15 MA0052.4 MEF2A MA0052.4 DDCTAAAAATAGMHH MEF2A 2.92e-14 1.68e-16 569 88.5 57700 75.2 1.18 ESR_clop
95 5 MA0720.1 Shox2 MA0720.1 YYAATTAR Shox2 3.72e-14 2.11e-16 607 94.4 64000 83.5 1.13 ESR_clop
96 10 MA0785.1 POU2F1 MA0785.1 AWTATGCWAATK POU2F1 4.71e-14 2.65e-16 515 80.1 49900 65 1.23 ESR_clop
97 5 MA0876.1 BSX MA0876.1 SYVATTAV BSX 1.15e-13 6.42e-16 601 93.5 63100 82.3 1.14 ESR_clop
98 12 MA0042.2 FOXI1 MA0042.2 GTAAACA FOXI1 1.55e-13 8.53e-16 588 91.4 61000 79.5 1.15 ESR_clop
99 5 MA0726.1 VSX2 MA0726.1 CTAATTAN VSX2 1.69e-13 9.19e-16 607 94.4 64200 83.8 1.13 ESR_clop
100 5 MA0899.1 HOXA10 MA0899.1 DGYMATAAAAH HOXA10 1.94e-13 1.05e-15 621 96.6 66900 87.3 1.11 ESR_clop
101 10 MA0627.2 POU2F3 MA0627.2 NWTATGCAAATNH POU2F3 2.33e-13 1.25e-15 552 85.8 55400 72.3 1.19 ESR_clop
102 13 MA0077.1 SOX9 MA0077.1 CYATTGTTY SOX9 3.35e-13 1.77e-15 588 91.4 61100 79.7 1.15 ESR_clop
103 12 MA0032.2 FOXC1 MA0032.2 WAWGTAAAYAW FOXC1 3.6e-13 1.89e-15 484 75.3 46000 60.1 1.25 ESR_clop
104 5 MA0887.1 EVX1 MA0887.1 VVTAATTABS EVX1 3.75e-13 1.94e-15 522 81.2 51200 66.8 1.22 ESR_clop
105 5 MA0700.2 LHX2 MA0700.2 DDCCAATTADN LHX2 3.97e-13 2.04e-15 565 87.9 57500 75 1.17 ESR_clop
106 1 MA0611.2 Dux MA0611.2 NTGATTBAATCAVWNN Dux 4.74e-13 2.41e-15 292 45.4 23200 30.2 1.51 ESR_clop
107 16 MA0495.3 MAFF MA0495.3 DWGTCAGCATTTTWHN MAFF 5.49e-13 2.77e-15 600 93.3 63200 82.4 1.13 ESR_clop
108 5 MA0699.1 LBX2 MA0699.1 NCYAATTARN LBX2 5.97e-13 2.98e-15 603 93.8 63700 83.1 1.13 ESR_clop
109 17 MA0102.4 CEBPA MA0102.4 NDATTGCACAATHN CEBPA 6.69e-13 3.31e-15 602 93.6 63600 82.9 1.13 ESR_clop
110 5 MA0709.1 Msx3 MA0709.1 SCAATTAN Msx3 7.8e-13 3.82e-15 560 87.1 56800 74.2 1.17 ESR_clop
111 12 MA0848.1 FOXO4 MA0848.1 GTAAACA FOXO4 7.93e-13 3.85e-15 590 91.8 61600 80.3 1.14 ESR_clop
112 5 MA0879.2 DLX1 MA0879.2 VYAATTAN DLX1 8.9e-13 4.29e-15 556 86.5 56300 73.4 1.18 ESR_clop
113 5 MA0891.1 GSC2 MA0891.1 NYTAATCCBH GSC2 1.08e-12 5.13e-15 611 95 65200 85.1 1.12 ESR_clop
114 5 MA1549.1 POU6F1 MA1549.1 RTAATGAGVN POU6F1 1.32e-12 6.26e-15 494 76.8 47600 62.1 1.24 ESR_clop
115 5 MA0912.2 HOXD3 MA0912.2 CTAATTAC HOXD3 1.39e-12 6.54e-15 321 49.9 26500 34.6 1.44 ESR_clop
116 5 MA0716.1 PRRX1 MA0716.1 YYAATTAR PRRX1 1.56e-12 7.28e-15 501 77.9 48600 63.4 1.23 ESR_clop
117 5 MA0662.1 MIXL1 MA0662.1 NBYAATTAVN MIXL1 1.79e-12 8.26e-15 508 79 49600 64.7 1.22 ESR_clop
118 5 MA1497.1 HOXA6 MA1497.1 BGYMATTANN HOXA6 2.18e-12 9.95e-15 616 95.8 66300 86.5 1.11 ESR_clop
119 5 MA0710.1 NOTO MA0710.1 NYTAATTAVN NOTO 2.22e-12 1.01e-14 516 80.2 50700 66.2 1.21 ESR_clop
120 5 MA0666.2 MSX1 MA0666.2 SCAATTAR MSX1 2.33e-12 1.05e-14 521 81 51400 67.1 1.21 ESR_clop
121 18 MA0905.1 HOXC10 MA0905.1 GTCRTAAAAH HOXC10 2.44e-12 1.09e-14 545 84.8 54800 71.5 1.19 ESR_clop
122 2 MA0140.2 GATA1::TAL1 MA0140.2 MTTATCWSNNNNNHVCAG GATA1::TAL1 3.16e-12 1.4e-14 295 45.9 23800 31.1 1.48 ESR_clop
123 5 MA1519.1 LHX5 MA1519.1 STAATTAV LHX5 3.69e-12 1.61e-14 357 55.5 30800 40.2 1.38 ESR_clop
124 5 MA0725.1 VSX1 MA0725.1 YTAATTAN VSX1 3.71e-12 1.61e-14 604 93.9 64200 83.7 1.12 ESR_clop
125 12 MA0041.2 FOXD3 MA0041.2 WAWGHAAATAAACARY FOXD3 3.93e-12 1.69e-14 564 87.7 57700 75.3 1.16 ESR_clop
126 10 MA0788.1 POU3F3 MA0788.1 WWTATGCWAATTW POU3F3 4.06e-12 1.74e-14 479 74.5 45800 59.8 1.25 ESR_clop
127 5 MA0881.1 Dlx4 MA0881.1 VYAATTAN Dlx4 4.13e-12 1.75e-14 567 88.2 58200 75.9 1.16 ESR_clop
128 5 MA0705.1 Lhx8 MA0705.1 CTAATTAV Lhx8 4.47e-12 1.88e-14 417 64.8 38000 49.6 1.31 ESR_clop
129 12 MA0157.3 Foxo3 MA0157.3 NDGTAAACARNN Foxo3 5.64e-12 2.36e-14 625 97.2 68200 89 1.09 ESR_clop
130 1 MA1639.1 MEIS1 MA1639.1 NHCATMAATCAHN MEIS1 6.87e-12 2.85e-14 296 46 24100 31.4 1.47 ESR_clop
131 12 MA0852.2 FOXK1 MA0852.2 NRDGTAAACAAGNN FOXK1 7.55e-12 3.11e-14 618 96.1 66800 87.2 1.1 ESR_clop
132 5 MA0708.2 MSX2 MA0708.2 SCAATTAV MSX2 8.21e-12 3.36e-14 533 82.9 53300 69.6 1.19 ESR_clop
133 12 MA0480.2 Foxo1 MA0480.2 NDGTAAACANN Foxo1 8.94e-12 3.62e-14 597 92.8 63100 82.4 1.13 ESR_clop
134 5 MA1505.1 HOXC8 MA1505.1 KTAATTAM HOXC8 1.55e-11 6.22e-14 620 96.4 67300 87.8 1.1 ESR_clop
135 6 MA0046.2 HNF1A MA0046.2 DRTTAATNATTAACN HNF1A 1.67e-11 6.66e-14 343 53.3 29500 38.5 1.39 ESR_clop
136 5 MA0892.1 GSX1 MA0892.1 NCYMATTAVN GSX1 2e-11 7.93e-14 618 96.1 67000 87.4 1.1 ESR_clop
137 5 MA0882.1 DLX6 MA0882.1 VYAATTAN DLX6 3.48e-11 1.37e-13 564 87.7 58100 75.8 1.16 ESR_clop
138 5 MA0125.1 Nobox MA0125.1 TAATTRSY Nobox 3.85e-11 1.51e-13 589 91.6 62000 81 1.13 ESR_clop
139 5 MA1530.1 NKX6-3 MA1530.1 VYCATTAWW NKX6-3 3.96e-11 1.54e-13 404 62.8 36800 48.1 1.31 ESR_clop
140 9 MA0755.1 CUX2 MA0755.1 TRATCGATAW CUX2 9.48e-11 3.65e-13 382 59.4 34400 44.8 1.33 ESR_clop
141 5 MA1481.1 DRGX MA1481.1 YYAATTAN DRGX 1.04e-10 4e-13 501 77.9 49400 64.5 1.21 ESR_clop
142 6 MA0153.2 HNF1B MA0153.2 GTTAATNATTAAY HNF1B 1.24e-10 4.7e-13 338 52.6 29300 38.2 1.38 ESR_clop
143 5 MA0701.2 LHX9 MA0701.2 CYAATTAR LHX9 1.39e-10 5.25e-13 381 59.2 34300 44.8 1.32 ESR_clop
144 19 MA0122.3 Nkx3-2 MA0122.3 WWAAMCACTTAAN Nkx3-2 1.5e-10 5.6e-13 573 89.1 59800 78 1.14 ESR_clop
145 5 MA0889.1 GBX1 MA0889.1 VCYAATTASY GBX1 1.65e-10 6.13e-13 540 84 54900 71.6 1.17 ESR_clop
146 20 MA0901.2 HOXB13 MA0901.2 WDCCAATAAAAWWW HOXB13 1.89e-10 6.97e-13 533 82.9 53900 70.4 1.18 ESR_clop
147 12 MA0481.3 FOXP1 MA0481.3 NDGTAAACANH FOXP1 2.61e-10 9.58e-13 494 76.8 48700 63.5 1.21 ESR_clop
148 10 MA0789.1 POU3F4 MA0789.1 TATGCWAAT POU3F4 2.84e-10 1.03e-12 512 79.6 51100 66.7 1.19 ESR_clop
149 5 MA1499.1 HOXB4 MA1499.1 RTMATTAR HOXB4 4.61e-10 1.67e-12 423 65.8 39700 51.8 1.27 ESR_clop
150 17 MA1636.1 CEBPG MA1636.1 NDATGATGCAATMHH CEBPG 6.44e-10 2.31e-12 512 79.6 51300 66.9 1.19 ESR_clop
151 21 MA1143.1 FOSL1::JUND MA1143.1 RTGACGTMAY FOSL1::JUND 8.88e-10 3.17e-12 237 36.9 18600 24.3 1.52 ESR_clop
152 12 MA0031.1 FOXD1 MA0031.1 GTAAACAW FOXD1 1.16e-09 4.12e-12 495 77 49100 64.1 1.2 ESR_clop
153 5 MA1476.2 Dlx5 MA1476.2 NDGCAATTAGNN Dlx5 1.38e-09 4.85e-12 594 92.4 63500 82.8 1.12 ESR_clop
154 5 MA0895.1 HMBOX1 MA0895.1 MYTAGTTAMS HMBOX1 1.78e-09 6.22e-12 437 68 41700 54.4 1.25 ESR_clop
155 11 MA0711.1 OTX1 MA0711.1 HTAATCCS OTX1 2.65e-09 9.22e-12 586 91.1 62300 81.3 1.12 ESR_clop
156 5 MA1500.1 HOXB6 MA1500.1 BTAATKRC HOXB6 3.66e-09 1.26e-11 579 90 61300 80 1.13 ESR_clop
157 5 MA0635.1 BARHL2 MA0635.1 VHTAAAYGRT BARHL2 3.94e-09 1.35e-11 547 85.1 56500 73.8 1.15 ESR_clop
158 12 MA0033.2 FOXL1 MA0033.2 RTAAACA FOXL1 7.81e-09 2.67e-11 465 72.3 45600 59.5 1.22 ESR_clop
159 1 MA0591.1 Bach1::Mafk MA0591.1 RSSATGACTCAGCAB Bach1::Mafk 1.05e-08 3.57e-11 184 28.6 13600 17.8 1.62 ESR_clop
160 10 MA1115.1 POU5F1 MA1115.1 WHATGCAAATN POU5F1 1.13e-08 3.8e-11 496 77.1 49700 64.9 1.19 ESR_clop
161 22 MA0108.2 TBP MA0108.2 STATAAAWRSVVVBN TBP 1.23e-08 4.11e-11 563 87.6 59100 77.1 1.14 ESR_clop
162 5 MA0900.2 HOXA2 MA0900.2 STAATTAS HOXA2 1.48e-08 4.93e-11 286 44.5 24400 31.8 1.4 ESR_clop
163 19 MA1523.1 MSANTD3 MA1523.1 STVCACTCAC MSANTD3 1.6e-08 5.29e-11 618 96.1 68000 88.7 1.08 ESR_clop
164 21 MA1632.1 ATF2 MA1632.1 NNATGABGTCATN ATF2 1.87e-08 6.15e-11 452 70.3 44100 57.6 1.22 ESR_clop
165 5 MA0724.1 VENTX MA0724.1 AMCGATTAR VENTX 2.22e-08 7.27e-11 428 66.6 41100 53.7 1.24 ESR_clop
166 10 MA0792.1 POU5F1B MA0792.1 TATGCWAAT POU5F1B 2.84e-08 9.24e-11 541 84.1 56100 73.2 1.15 ESR_clop
167 5 MA0880.1 Dlx3 MA0880.1 NYAATTAN Dlx3 2.88e-08 9.31e-11 532 82.7 54800 71.6 1.16 ESR_clop
168 17 MA0043.3 HLF MA0043.3 NNRTTATGCAACHN HLF 3.67e-08 1.18e-10 468 72.8 46300 60.4 1.21 ESR_clop
169 17 MA0025.2 NFIL3 MA0025.2 NRTTATGYAATNN NFIL3 4.22e-08 1.35e-10 499 77.6 50400 65.8 1.18 ESR_clop
170 21 MA1129.1 FOSL1::JUN MA1129.1 ATGACGTCAT FOSL1::JUN 4.59e-08 1.46e-10 547 85.1 57100 74.4 1.14 ESR_clop
171 21 MA0018.4 CREB1 MA0018.4 NNRTGATGTCAYN CREB1 5.15e-08 1.62e-10 523 81.3 53700 70.1 1.16 ESR_clop
172 23 MA0829.2 SREBF1 MA0829.2 DNATCACSTGATNH SREBF1 5.6e-08 1.76e-10 286 44.5 24700 32.2 1.38 ESR_clop
173 24 MA0050.3 Irf1 MA0050.3 ANTGAAACTGAAASH Irf1 5.79e-08 1.81e-10 598 93 64800 84.6 1.1 ESR_clop
174 5 MA0885.2 Dlx2 MA0885.2 NDGCAATTAGNN Dlx2 6.21e-08 1.92e-10 583 90.7 62400 81.5 1.11 ESR_clop
175 20 MA0650.3 Hoxa13 MA0650.3 NNCCAATAAAAN Hoxa13 8.84e-08 2.72e-10 571 88.8 60700 79.2 1.12 ESR_clop
176 13 MA0078.2 Sox17 MA0078.2 NNAGAACAATGGNN Sox17 1.32e-07 4.06e-10 585 91 62900 82.1 1.11 ESR_clop
177 11 MA0883.1 Dmbx1 MA0883.1 WDRWNMGGATTADKNNW Dmbx1 4.76e-07 1.45e-09 392 61 37400 48.9 1.25 ESR_clop
178 5 MA0654.1 ISX MA0654.1 YYAATTAR ISX 7.06e-07 2.14e-09 397 61.7 38100 49.8 1.24 ESR_clop
179 9 MA0851.1 Foxj3 MA0851.1 NDAADGTAAACAAANNM Foxj3 7.54e-07 2.27e-09 411 63.9 39900 52 1.23 ESR_clop
180 13 MA1120.1 SOX13 MA1120.1 DVACAATGGNN SOX13 7.67e-07 2.3e-09 537 83.5 56300 73.4 1.14 ESR_clop
181 21 MA1126.1 FOS::JUN MA1126.1 DRTGACGTCATHNDTN FOS::JUN 8.59e-07 2.56e-09 433 67.3 42600 55.6 1.21 ESR_clop
182 21 MA1131.1 FOSL2::JUN MA1131.1 GRTGACGTMAT FOSL2::JUN 1.09e-06 3.24e-09 400 62.2 38600 50.4 1.24 ESR_clop
183 21 MA1136.1 FOSB::JUNB MA1136.1 RTGACGTCAT FOSB::JUNB 1.17e-06 3.45e-09 528 82.1 55100 71.9 1.14 ESR_clop
184 5 MA1496.1 HOXA4 MA1496.1 RTMATTAV HOXA4 1.22e-06 3.56e-09 499 77.6 51200 66.8 1.16 ESR_clop
185 20 MA1125.1 ZNF384 MA1125.1 DNWMAAAAAAAA ZNF384 2.12e-06 6.17e-09 79 12.3 4600 6 2.07 ESR_clop
186 13 MA0143.4 SOX2 MA0143.4 DNACAATGGNN SOX2 2.71e-06 7.85e-09 468 72.8 47400 61.8 1.18 ESR_clop
187 1 MA1124.1 ZNF24 MA1124.1 CATTCATTCATTC ZNF24 3.23e-06 9.32e-09 366 56.9 34800 45.4 1.25 ESR_clop
188 25 MA0769.2 TCF7 MA0769.2 NNCTTTGAWVT TCF7 3.27e-06 9.38e-09 553 86 58800 76.8 1.12 ESR_clop
189 5 MA0075.3 PRRX2 MA0075.3 CTAATTAN PRRX2 4.09e-06 1.17e-08 329 51.2 30500 39.8 1.29 ESR_clop
190 24 MA1623.1 Stat2 MA1623.1 RGAAACAGAAASH Stat2 4.27e-06 1.21e-08 575 89.4 62100 81 1.1 ESR_clop
191 5 MA1498.2 HOXA7 MA1498.2 SYMATTAV HOXA7 5.23e-06 1.47e-08 500 77.8 51700 67.4 1.15 ESR_clop
192 5 MA0132.2 PDX1 MA0132.2 VYAATTAR PDX1 5.25e-06 1.47e-08 408 63.4 40000 52.2 1.22 ESR_clop
193 13 MA1152.1 SOX15 MA1152.1 CYWTTGTTHW SOX15 5.27e-06 1.47e-08 406 63.1 39800 51.9 1.22 ESR_clop
194 17 MA0833.2 ATF4 MA0833.2 DDATGATGCAATMN ATF4 5.53e-06 1.54e-08 259 40.3 22700 29.6 1.36 ESR_clop
195 17 MA0836.2 CEBPD MA0836.2 NRTTGCACAAYHN CEBPD 8.66e-06 2.39e-08 530 82.4 55900 72.9 1.13 ESR_clop
196 5 MA0893.2 GSX2 MA0893.2 SYMATTAR GSX2 1.14e-05 3.13e-08 603 93.8 66600 86.9 1.08 ESR_clop
197 26 MA1562.1 SOX14 MA1562.1 CCGAACAATG SOX14 1.38e-05 3.77e-08 440 68.4 44200 57.7 1.19 ESR_clop
198 27 MA1581.1 (ZBTB6) MEME-11 CCTGGGCTCAAGYRA CCTGGGCTCAAGYRA ZBTB6 1.56e-05 4.24e-08 23 3.58 648 0.85 4.4 ESR_clop
199 5 MA0875.1 BARX1 MA0875.1 VCMATTAV BARX1 1.76e-05 4.78e-08 521 81 54800 71.5 1.13 ESR_clop
200 9 MA0757.1 ONECUT3 MA0757.1 AAAAAATCRATAAH ONECUT3 1.85e-05 4.99e-08 244 38 21300 27.8 1.37 ESR_clop
201 23 MA0093.3 USF1 MA0093.3 NDGTCATGTGACHN USF1 2.12e-05 5.69e-08 550 85.5 58900 76.8 1.11 ESR_clop
202 28 MA1125.1 (ZNF384) MEME-2 TTTTTTTTTTTTTTT TTTTTTTTTTTTTTT ZNF384 2.52e-05 6.73e-08 247 38.4 21700 28.4 1.36 ESR_clop
203 4 MA0070.1 PBX1 MA0070.1 HCATCAATCAAW PBX1 2.63e-05 6.99e-08 255 39.7 22600 29.5 1.35 ESR_clop
204 17 MA0838.1 CEBPG MA0838.1 ATTRCGCAAY CEBPG 3.11e-05 8.23e-08 83 12.9 5250 6.86 1.9 ESR_clop
205 12 MA0047.3 FOXA2 MA0047.3 RWGTAAACANN FOXA2 3.17e-05 8.35e-08 362 56.3 34900 45.6 1.24 ESR_clop
206 19 MA0897.1 Hmx2 MA0897.1 ASAAGCAATTAAHVVRT Hmx2 3.7e-05 9.68e-08 399 62 39400 51.4 1.21 ESR_clop
207 5 MA1504.1 HOXC4 MA1504.1 VTMATTAN HOXC4 4.14e-05 1.08e-07 342 53.2 32600 42.6 1.25 ESR_clop
208 29 MA0782.2 PKNOX1 MA0782.2 NNTGAGTGACAGVNN PKNOX1 4.25e-05 1.1e-07 169 26.3 13600 17.7 1.49 ESR_clop
209 5 MA1608.1 Isl1 MA1608.1 NNCCATTAGNN Isl1 5.03e-05 1.3e-07 464 72.2 47600 62.1 1.16 ESR_clop
210 12 MA1489.1 FOXN3 MA1489.1 GTAAACAA FOXN3 5.72e-05 1.47e-07 356 55.4 34400 44.9 1.24 ESR_clop
211 19 MA0063.2 NKX2-5 MA0063.2 NNCACTCAANN NKX2-5 6.82e-05 1.74e-07 413 64.2 41300 53.9 1.19 ESR_clop
212 30 MA0508.3 PRDM1 MA0508.3 YNCTTTCTCTH PRDM1 7.6e-05 1.93e-07 599 93.2 66400 86.6 1.08 ESR_clop
213 19 MA0898.1 Hmx3 MA0898.1 ASAAGCAATTAAWRRAT Hmx3 7.69e-05 1.94e-07 426 66.2 42900 56 1.18 ESR_clop
214 28 MA1125.1 (ZNF384) STREME-7 7-AGAAAAAAAAAW AGAAAAAAAAAW ZNF384 7.71e-05 1.94e-07 68 10.6 4060 5.3 2.02 ESR_clop
215 19 MA1994.1 Nkx2-1 MA1994.1 NVCACTTGARHNN Nkx2-1 8.82e-05 2.21e-07 594 92.4 65600 85.6 1.08 ESR_clop
216 13 MA0514.2 Sox3 MA0514.2 DNACAATGGNN Sox3 0.000102 2.55e-07 535 83.2 57200 74.6 1.12 ESR_clop
217 26 MA1563.2 SOX18 MA1563.2 AACAATDV SOX18 0.000125 3.12e-07 500 77.8 52500 68.5 1.14 ESR_clop
218 18 MA0908.1 HOXD11 MA0908.1 RTCGTAAAAH HOXD11 0.000149 3.69e-07 283 44 26200 34.2 1.29 ESR_clop
219 12 MA0613.1 FOXG1 MA0613.1 RTAAACAW FOXG1 0.00015 3.7e-07 346 53.8 33500 43.7 1.23 ESR_clop
220 31 MA1112.2 NR4A1 MA1112.2 NNAAAGGTCANN NR4A1 0.000197 4.82e-07 575 89.4 63000 82.2 1.09 ESR_clop
221 5 MA1518.2 Lhx1 MA1518.2 NNNTGCTAATTAGCANNN Lhx1 0.000238 5.81e-07 396 61.6 39600 51.6 1.19 ESR_clop
222 5 MA1463.1 ARGFX MA1463.1 DCTAATTARM ARGFX 0.000298 7.24e-07 333 51.8 32100 41.9 1.24 ESR_clop
223 5 MA0853.1 Alx4 MA0853.1 CGCRYTAATTARYHNNY Alx4 0.000365 8.82e-07 313 48.7 29900 39 1.25 ESR_clop
224 32 MA1657.1 ZNF652 MA1657.1 BAAAGRGTTAAN ZNF652 0.000382 9.21e-07 431 67 44000 57.4 1.17 ESR_clop
225 5 MA1501.1 HOXB7 MA1501.1 GGTAATTAVS HOXB7 0.000608 1.46e-06 540 84 58300 76.1 1.1 ESR_clop
226 33 MA1603.1 Dmrt1 MA1603.1 GHTACAAAGTADC Dmrt1 0.000612 1.46e-06 365 56.8 36100 47.2 1.21 ESR_clop
227 26 MA1561.1 SOX12 MA1561.1 ACCGAACAATV SOX12 0.000618 1.47e-06 268 41.7 24900 32.5 1.29 ESR_clop
228 12 MA1487.2 FOXE1 MA1487.2 VYTAAAYAAACAAH FOXE1 0.000629 1.49e-06 32 4.98 1400 1.83 2.79 ESR_clop
229 34 MA1973.1 (ZKSCAN3) MEME-3 TGTYRCCCAGGCTGG TGTYRCCCAGGCTGG ZKSCAN3 0.000755 1.78e-06 91 14.2 6420 8.38 1.7 ESR_clop
230 23 MA1618.1 Ptf1a MA1618.1 NNACAGATGTTNN Ptf1a 0.000776 1.82e-06 495 77 52400 68.4 1.13 ESR_clop
231 23 MA2001.1 Six4 MA2001.1 GDAACCTGANH Six4 0.000932 2.18e-06 540 84 58400 76.2 1.1 ESR_clop
232 19 MA1645.1 NKX2-2 MA1645.1 NNNCCACTCAANNN NKX2-2 0.000961 2.23e-06 387 60.2 38900 50.8 1.19 ESR_clop
233 35 6-AGGTTGCAAT STREME-6 6-AGGTTGCAAT AGGTTGCAAT AGGTTGCAAT 0.00104 2.41e-06 48 7.47 2670 3.49 2.18 ESR_clop
234 36 MA1975.1 ZNF214 MA1975.1 VWTCATCAABGTCCT ZNF214 0.00111 2.55e-06 544 84.6 59000 77 1.1 ESR_clop
235 37 MA1720.1 ZNF85 MA1720.1 DHDGAGATTACWKCAK ZNF85 0.00115 2.65e-06 436 67.8 45000 58.7 1.16 ESR_clop
236 38 MA1707.1 DMRTA1 MA1707.1 AWTTGWTACAWT DMRTA1 0.00117 2.68e-06 539 83.8 58400 76.2 1.1 ESR_clop
237 39 MA0631.1 Six3 MA0631.1 DATRGGGTATCAYNWNT Six3 0.00164 3.74e-06 325 50.5 31700 41.4 1.22 ESR_clop
238 38 MA1478.1 DMRTA2 MA1478.1 AATTGHTACAWT DMRTA2 0.00173 3.93e-06 577 89.7 63800 83.2 1.08 ESR_clop
239 16 MA0117.2 Mafb MA0117.2 AWWNTGCTGACD Mafb 0.00192 4.34e-06 334 51.9 32800 42.8 1.21 ESR_clop
240 23 MA1118.1 SIX1 MA1118.1 GWAACCTGAKM SIX1 0.00198 4.45e-06 482 75 51000 66.5 1.13 ESR_clop
241 40 MA0483.1 Gfi1B MA0483.1 AAATCWCWGCH Gfi1B 0.00209 4.67e-06 407 63.3 41600 54.3 1.17 ESR_clop
242 23 MA0596.1 SREBF2 MA0596.1 RTGGGGTGAY SREBF2 0.00222 4.96e-06 173 26.9 14900 19.4 1.39 ESR_clop
243 1 MA1520.1 MAF MA1520.1 NTGCTGASTCAGCAH MAF 0.00224 4.96e-06 148 23 12300 16 1.45 ESR_clop
244 7 MA1960.1 MGA::EVX1 MA1960.1 RGGTGWTAATKD MGA::EVX1 0.00231 5.1e-06 279 43.4 26500 34.6 1.26 ESR_clop
245 41 MA0606.2 Nfat5 MA0606.2 NNATGGAAAAWN Nfat5 0.00238 5.24e-06 625 97.2 71300 93 1.04 ESR_clop
246 23 MA1119.1 SIX2 MA1119.1 NNCTGAAACCTGATMY SIX2 0.00248 5.44e-06 463 72 48600 63.4 1.14 ESR_clop
247 9 MA0754.2 CUX1 MA0754.2 TAATCGATAM CUX1 0.00282 6.16e-06 314 48.8 30600 39.9 1.22 ESR_clop
248 42 8-STAYCTCAT STREME-8 8-STAYCTCAT STAYCTCAT STAYCTCAT 0.00329 7.15e-06 519 80.7 56000 73 1.11 ESR_clop
249 21 MA1133.1 JUN::JUNB MA1133.1 KRTGACGTCATN JUN::JUNB 0.00341 7.38e-06 551 85.7 60300 78.7 1.09 ESR_clop
12 46 GYGAGACYCTGTCTC MEME-7 GYGAGACYCTGTCTC GYGAGACYCTGTCTC GYGAGACYCTGTCTC 0.00344 0.000286 11 1.71 335 0.44 4.25 ESR_clop
250 21 MA1145.1 FOSL2::JUND MA1145.1 NNRTGACGTCAYHSN FOSL2::JUND 0.00349 7.53e-06 240 37.3 22300 29 1.29 ESR_clop
251 23 MA0620.3 MITF MA0620.3 NNNDRTCACGTGAYHNNN MITF 0.00356 7.64e-06 381 59.2 38600 50.4 1.18 ESR_clop
252 17 MA0837.2 CEBPE MA0837.2 KATTGCGCAATM CEBPE 0.00366 7.83e-06 95 14.8 7060 9.22 1.62 ESR_clop
253 5 MA1577.1 TLX2 MA1577.1 BYAATTAR TLX2 0.00369 7.87e-06 266 41.4 25200 32.9 1.26 ESR_clop
254 23 MA0595.1 SREBF1 MA0595.1 VTCACCCCAY SREBF1 0.00381 8.09e-06 120 18.7 9530 12.4 1.51 ESR_clop
255 19 MA0914.1 ISL2 MA0914.1 GCAMTTAR ISL2 0.00387 8.18e-06 518 80.6 55900 72.9 1.11 ESR_clop
256 6 MA0683.1 POU4F2 MA0683.1 RTGCATAATTAATGAG POU4F2 0.00396 8.33e-06 136 21.2 11200 14.6 1.46 ESR_clop
257 21 MA0492.1 JUND MA0492.1 DDDRATGABGTCATN JUND 0.00418 8.77e-06 123 19.1 9850 12.8 1.5 ESR_clop
258 17 MA0466.3 CEBPB MA0466.3 KATTGCGCAATM CEBPB 0.0046 9.61e-06 64 9.95 4220 5.5 1.83 ESR_clop
259 12 MA0845.1 FOXB1 MA0845.1 WATGTAAATAT FOXB1 0.00492 1.03e-05 232 36.1 21500 28 1.29 ESR_clop
260 43 MA0847.3 FOXD2 MA0847.3 SYTAARYAAACA FOXD2 0.00505 1.05e-05 112 17.4 8790 11.5 1.53 ESR_clop
13 47 MA0682.2 (PITX1) MEME-4 GCTGGGATTACAGGC GCTGGGATTACAGGC PITX1 0.00531 0.000408 66 10.3 5030 6.57 1.58 ESR_clop
261 13 MA0867.2 SOX4 MA0867.2 RAACAAAGRV SOX4 0.00582 1.2e-05 481 74.8 51200 66.8 1.12 ESR_clop
262 5 MA0068.2 PAX4 MA0068.2 CTAATTAG PAX4 0.00587 1.21e-05 333 51.8 33100 43.1 1.2 ESR_clop
263 5 MA0601.1 Arid3b MA0601.1 ATATTAATWAN Arid3b 0.00588 1.21e-05 354 55 35500 46.4 1.19 ESR_clop
264 16 MA0842.2 NRL MA0842.2 AAWWNTGCTGACG NRL 0.00855 1.75e-05 98 15.2 7510 9.8 1.57 ESR_clop
265 12 MA0846.1 FOXC2 MA0846.1 WAWGTAAACAWW FOXC2 0.00985 2.01e-05 38 5.91 2080 2.72 2.23 ESR_clop
266 44 MA0693.3 Vdr MA0693.3 NNGAGTTCANN Vdr 0.0112 2.26e-05 482 75 51500 67.2 1.12 ESR_clop
267 5 MA1507.1 HOXD4 MA1507.1 VTMATTAD HOXD4 0.0114 2.3e-05 195 30.3 17600 23 1.32 ESR_clop
268 12 MA0850.1 FOXP3 MA0850.1 RTAAACA FOXP3 0.0116 2.33e-05 420 65.3 43800 57.1 1.14 ESR_clop
269 23 MA1570.1 TFAP4 MA1570.1 AHCATRTGDT TFAP4 0.0121 2.42e-05 153 23.8 13200 17.2 1.39 ESR_clop
270 5 MA0712.2 OTX2 MA0712.2 NDRGGATTARNN OTX2 0.0154 3.08e-05 247 38.4 23500 30.6 1.26 ESR_clop
271 21 MA1139.1 FOSL2::JUNB MA1139.1 DATGACGTCATH FOSL2::JUNB 0.0167 3.32e-05 224 34.8 20900 27.3 1.28 ESR_clop
14 48 MA1515.1 (KLF2) MEME-10 GCYRGGCRTGGTGGC GCYRGGCRTGGTGGC KLF2 0.0173 0.00124 28 4.35 1720 2.24 2.01 ESR_clop
272 41 MA0152.2 Nfatc2 MA0152.2 NNRNAATGGAAANWNH Nfatc2 0.0189 3.75e-05 583 90.7 65300 85.2 1.06 ESR_clop
273 16 MA1995.1 Npas4 MA1995.1 NNTCGTGACHN Npas4 0.0242 4.77e-05 406 63.1 42300 55.2 1.15 ESR_clop
274 17 MA0843.1 TEF MA0843.1 BRTTACRTAAYM TEF 0.0242 4.77e-05 220 34.2 20600 26.9 1.28 ESR_clop
275 21 MA0488.1 JUN MA0488.1 DDRATGATGTCAT JUN 0.0249 4.89e-05 126 19.6 10500 13.8 1.43 ESR_clop
276 5 MA1963.1 SATB1 MA1963.1 WWDCTAATAAHWW SATB1 0.0258 5.04e-05 286 44.5 28100 36.6 1.22 ESR_clop
277 45 MA0144.2 STAT3 MA0144.2 YTTCYKGGAAD STAT3 0.0291 5.66e-05 417 64.8 43700 57 1.14 ESR_clop
278 29 MA0498.2 MEIS1 MA0498.2 HTGACAD MEIS1 0.0304 5.89e-05 611 95 69500 90.7 1.05 ESR_clop
279 23 MA0626.1 Npas2 MA0626.1 NSCACGTGTN Npas2 0.0362 6.99e-05 347 54 35300 46.1 1.17 ESR_clop
280 21 MA1127.1 FOSB::JUN MA1127.1 GATGACGTCAT FOSB::JUN 0.0446 8.59e-05 227 35.3 21600 28.2 1.26 ESR_clop
15 49 MA1107.2 (KLF9) MEME-8 GTGWGTGTRDRTGTG GTGWGTGTRDRTGTG KLF9 0.0519 0.00346 17 2.64 925 1.21 2.31 ESR_clop
16 50 5-ACTCCA STREME-5 5-ACTCCA ACTCCA ACTCCA 0.156 0.00975 568 88.3 65100 85 1.04 ESR_clop
17 35 GCTCACTGCAACCTC MEME-6 GCTCACTGCAACCTC GCTCACTGCAACCTC GCTCACTGCAACCTC 0.377 0.0222 4 0.62 119 0.16 4.96 ESR_clop
18 51 MA1596.1 (ZNF460) MEME-5 CCTRYCTCWBCCTCY CCTRYCTCWBCCTCY ZNF460 0.545 0.0303 402 62.5 45000 58.8 1.07 ESR_clop
19 52 GATYRYRCCACTGCA MEME-9 GATYRYRCCACTGCA GATYRYRCCACTGCA GATYRYRCCACTGCA 19 1 0 0 2 0 39.7 ESR_clop 
ER_rat <- 1.25
mrc_type <- "ESR_clop"
ESR_clop_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

ESR_clop_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.1), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.1,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

LR_open data

LR_open_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_open_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
LR_open_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_open_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
LR_open_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_open_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
LR_open_sea_all <- rbind(LR_open_sea_disc, LR_open_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)
LR_open_combo <- LR_open_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., LR_open_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="LR_open")

LR_open_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")
Enriched motifs 200 bp in EAR open v NR
RANK CLUSTER SIM_MOTIF ALT_ID ID CONSENSUS.x motif_name EVALUE.y QVALUE TP TP. FP FP. ENR_RATIO mrc_type
1 1 MA1134.1 (FOS::JUNB) STREME-1 1-DATGASTCATH DATGASTCATH FOS::JUNB 0 0 11700 50.9 12000 15.6 3.26 LR_open
2 1 MA1988.1 (Atf3) MEME-1 DRTGACTCAYH DRTGACTCAYH Atf3 0 0 11500 49.9 11500 15.1 3.32 LR_open
3 1 MA1144.1 FOSL2::JUND MA1144.1 KATGACTCAT FOSL2::JUND 0 0 11600 50.2 12000 15.6 3.22 LR_open
4 1 MA1135.1 FOSB::JUNB MA1135.1 KRTGASTCAT FOSB::JUNB 0 0 12100 52.4 13200 17.3 3.03 LR_open
5 1 MA1134.1 FOS::JUNB MA1134.1 KATGASTCATHN FOS::JUNB 0 0 11900 51.6 12800 16.7 3.09 LR_open
6 1 MA0477.2 FOSL1 MA0477.2 NNATGACTCATNN FOSL1 0 0 11100 48 11000 14.3 3.36 LR_open
7 1 MA1138.1 FOSL2::JUNB MA1138.1 KRTGASTCAT FOSL2::JUNB 0 0 12400 53.7 14100 18.4 2.91 LR_open
8 1 MA0476.1 FOS MA0476.1 DVTGASTCATB FOS 0 0 12400 53.6 14200 18.5 2.9 LR_open
9 1 MA0489.2 Jun MA0489.2 NVTGACTCATNN Jun 0 0 10300 44.5 9450 12.3 3.61 LR_open
10 1 MA0490.2 JUNB MA0490.2 NNATGACTCATNN JUNB 0 0 11500 50 12300 16 3.13 LR_open
11 1 MA1130.1 FOSL2::JUN MA1130.1 NNRTGAGTCAYN FOSL2::JUN 0 0 11900 51.7 13200 17.2 3.01 LR_open
12 1 MA1141.1 FOS::JUND MA1141.1 NKATGAGTCATNN FOS::JUND 0 0 12100 52.4 13600 17.7 2.95 LR_open
13 1 MA0462.2 BATF::JUN MA0462.2 DATGACTCATH BATF::JUN 0 0 10900 47.4 10900 14.3 3.32 LR_open
14 1 MA1634.1 BATF MA1634.1 DATGACTCATH BATF 0 0 10700 46.4 10400 13.6 3.4 LR_open
15 1 MA1988.1 Atf3 MA1988.1 NRTGACTCABN Atf3 0 0 12000 52 13400 17.5 2.96 LR_open
16 1 MA0099.3 FOS::JUN MA0099.3 ATGAGTCAYM FOS::JUN 0 0 12300 53.4 14300 18.6 2.87 LR_open
17 1 MA0491.2 JUND MA0491.2 NNATGACTCATNN JUND 0 0 11700 50.8 12800 16.7 3.04 LR_open
18 1 MA0835.2 BATF3 MA0835.2 DATGACTCATH BATF3 0 0 11400 49.5 12200 15.9 3.11 LR_open
19 1 MA1128.1 FOSL1::JUN MA1128.1 NKATGACTCATNN FOSL1::JUN 0 0 12100 52.6 14000 18.2 2.89 LR_open
20 1 MA1633.2 BACH1 MA1633.2 ATGACTCAT BACH1 0 0 12700 55 15400 20.1 2.73 LR_open
21 1 MA1928.1 BNC2 MA1928.1 NDRTGAGTCABN BNC2 0 0 11300 49 12300 16 3.06 LR_open
22 1 MA1137.1 FOSL1::JUNB MA1137.1 NDRTGACTCATNN FOSL1::JUNB 0 0 11500 49.7 12700 16.6 2.99 LR_open
23 1 MA0478.1 FOSL2 MA0478.1 KRRTGASTCAB FOSL2 0 0 11600 50.4 13100 17.1 2.95 LR_open
24 1 MA0476.1 (FOS) STREME-10 10-TGANTCA 10-TGANTCA FOS 0 0 10600 46.1 10900 14.2 3.24 LR_open
25 1 MA0655.1 JDP2 MA0655.1 ATGACTCAT JDP2 0 0 10000 43.6 9660 12.6 3.46 LR_open
26 1 MA1142.1 FOSL1::JUND MA1142.1 NRTGACTCAT FOSL1::JUND 0 0 9840 42.7 9300 12.1 3.52 LR_open
27 1 MA1132.1 JUN::JUNB MA1132.1 KATGACKCAT JUN::JUNB 0 0 10800 46.9 12100 15.7 2.98 LR_open
28 1 MA1101.2 BACH2 MA1101.2 DWANCATGASTCATSNTWH BACH2 0 0 9410 40.8 9010 11.8 3.47 LR_open
29 1 MA0841.1 NFE2 MA0841.1 VATGACTCATS NFE2 0 0 8980 38.9 8420 11 3.54 LR_open
30 1 MA0089.2 MAFG::NFE2L1 MA0089.2 NVNATGACTCAGCADW MAFG::NFE2L1 0 0 12000 52.2 19300 25.1 2.08 LR_open
31 1 MA0496.3 MAFK MA0496.3 NGMTGACTCAGCMNH MAFK 0 0 10200 44.2 15000 19.5 2.27 LR_open
32 1 MA0501.1 MAF::NFE2 MA0501.1 ATGACTCAGCANWTY MAF::NFE2 0 0 11600 50.5 19700 25.7 1.97 LR_open
33 1 MA0150.2 Nfe2l2 MA0150.2 CASNATGACTCAGCA Nfe2l2 0 0 10900 47.1 19700 25.7 1.83 LR_open
34 2 2-ATKMAT STREME-2 2-ATKMAT ATKMAT ATKMAT 0 0 17900 77.8 45100 58.9 1.32 LR_open
35 1 MA0659.3 Mafg MA0659.3 NWGMTGACTCAGCAN Mafg 0 0 9690 42 18100 23.7 1.78 LR_open
36 3 MA0676.1 Nr2e1 MA0676.1 AAAAGTCAA Nr2e1 0 0 20300 87.9 55500 72.5 1.21 LR_open
37 1 MA1113.2 PBX2 MA1113.2 NHCATAAATCAHN PBX2 0 0 17600 76.2 44800 58.4 1.3 LR_open
38 1 MA1639.1 MEIS1 MA1639.1 NHCATMAATCAHN MEIS1 0 0 16300 70.7 40200 52.5 1.35 LR_open
39 1 MA1640.1 MEIS2 MA1640.1 NNATGATTTATGDNH MEIS2 0 0 20000 86.6 54700 71.3 1.21 LR_open
40 4 MA0790.1 POU4F1 MA0790.1 ATGMATAATTAATG POU4F1 0 0 17700 76.9 45700 59.7 1.29 LR_open
41 5 MA1978.1 ZNF354A MA1978.1 HWAADWATAAATGRAYWAWTT ZNF354A 0 0 19800 85.7 54200 70.7 1.21 LR_open
42 6 MA0845.1 FOXB1 MA0845.1 WATGTAAATAT FOXB1 0 0 20300 87.9 56400 73.6 1.19 LR_open
43 7 MA0886.1 EMX2 MA0886.1 VBTAATTARB EMX2 0 0 18700 81.3 50100 65.4 1.24 LR_open
44 8 MA0788.1 POU3F3 MA0788.1 WWTATGCWAATTW POU3F3 0 0 20000 86.7 55600 72.5 1.2 LR_open
45 8 MA0786.1 POU3F1 MA0786.1 WTATGCWAATKW POU3F1 0 0 20000 86.6 55600 72.6 1.19 LR_open
46 9 MA0680.2 Pax7 MA0680.2 DWTAATCAATTAWNH Pax7 0 0 18300 79.6 49000 63.9 1.24 LR_open
47 9 MA0681.2 PHOX2B MA0681.2 WWTAATCAAATTAWWW PHOX2B 0 0 17200 74.6 44700 58.3 1.28 LR_open
48 7 MA0902.2 HOXB2 MA0902.2 SYAATTAS HOXB2 0 0 17600 76.5 46500 60.6 1.26 LR_open
49 6 MA0032.2 FOXC1 MA0032.2 WAWGTAAAYAW FOXC1 0 0 21100 91.7 61100 79.7 1.15 LR_open
50 10 3-WTVWBAW STREME-3 3-WTVWBAW WTVWBAW WTVWBAW 0 0 21300 92.4 61900 80.8 1.14 LR_open
51 8 MA0785.1 POU2F1 MA0785.1 AWTATGCWAATK POU2F1 0 0 21000 91.1 60500 79 1.15 LR_open
52 6 MA0041.2 FOXD3 MA0041.2 WAWGHAAATAAACARY FOXD3 0 0 21300 92.2 61800 80.6 1.14 LR_open
53 4 MA0791.1 POU4F3 MA0791.1 RTGMATWATTAATGAR POU4F3 0 0 14900 64.8 37000 48.3 1.34 LR_open
54 6 MA0846.1 FOXC2 MA0846.1 WAWGTAAACAWW FOXC2 0 0 20600 89.4 58900 76.8 1.16 LR_open
55 8 MA0792.1 POU5F1B MA0792.1 TATGCWAAT POU5F1B 0 0 21500 93.1 63000 82.3 1.13 LR_open
56 7 MA0710.1 NOTO MA0710.1 NYTAATTAVN NOTO 0 0 21000 91.1 60900 79.4 1.15 LR_open
57 7 MA0628.1 POU6F1 MA0628.1 AYTAATTART POU6F1 0 0 19200 83.4 53200 69.4 1.2 LR_open
58 11 MA0052.4 MEF2A MA0052.4 DDCTAAAAATAGMHH MEF2A 0 0 20800 90.4 60100 78.4 1.15 LR_open
59 12 MA1143.1 FOSL1::JUND MA1143.1 RTGACGTMAY FOSL1::JUND 0 0 16200 70.5 42000 54.8 1.29 LR_open
60 8 MA0787.1 POU3F2 MA0787.1 WTATGCWAATKA POU3F2 0 0 18800 81.7 51800 67.6 1.21 LR_open
61 13 15-HHATDD STREME-15 15-HHATDD 15-HHATDD HHATDD 0 0 22000 95.2 65600 85.6 1.11 LR_open
62 7 MA1963.1 SATB1 MA1963.1 WWDCTAATAAHWW SATB1 0 0 18800 81.6 51800 67.6 1.21 LR_open
63 4 MA0046.2 HNF1A MA0046.2 DRTTAATNATTAACN HNF1A 0 0 13300 57.8 32200 42 1.38 LR_open
64 7 MA0713.1 PHOX2A MA0713.1 TAATYYAATTA PHOX2A 0 0 19300 83.6 53700 70 1.19 LR_open
65 14 MA0901.2 HOXB13 MA0901.2 WDCCAATAAAAWWW HOXB13 0 0 19500 84.5 54600 71.3 1.19 LR_open
66 7 MA0793.1 POU6F2 MA0793.1 ASCTMATTAW POU6F2 0 0 19700 85.6 55700 72.7 1.18 LR_open
67 9 MA0679.2 ONECUT1 MA0679.2 WAAAAATCAATAAWWN ONECUT1 0 0 17000 73.9 45200 59 1.25 LR_open
68 8 MA0627.2 POU2F3 MA0627.2 NWTATGCAAATNH POU2F3 0 0 19800 86 56100 73.2 1.17 LR_open
69 4 MA0153.2 HNF1B MA0153.2 GTTAATNATTAAY HNF1B 0 0 12900 56 31000 40.5 1.38 LR_open
70 8 MA1115.1 POU5F1 MA1115.1 WHATGCAAATN POU5F1 0 0 21800 94.4 64900 84.7 1.11 LR_open
71 8 MA0142.1 Pou5f1::Sox2 MA0142.1 CWTTGTYATGCAAAT Pou5f1::Sox2 0 0 18300 79.2 50000 65.3 1.21 LR_open
72 15 4-TRTAYA STREME-4 4-TRTAYA TRTAYA TRTAYA 0 0 21600 93.7 64300 83.9 1.12 LR_open
73 9 MA1471.1 BARX2 MA1471.1 NWWAAYMATTAN BARX2 0 0 18500 80.1 51000 66.5 1.2 LR_open
74 6 MA0148.4 FOXA1 MA0148.4 WWGTAAACATNN FOXA1 0 0 21000 91 61400 80.1 1.14 LR_open
75 7 MA0723.2 VAX2 MA0723.2 BYAATTAV VAX2 0 0 20400 88.5 58900 76.8 1.15 LR_open
76 7 MA0722.1 VAX1 MA0722.1 YTAATTAH VAX1 0 0 17900 77.7 48900 63.8 1.22 LR_open
77 8 MA0789.1 POU3F4 MA0789.1 TATGCWAAT POU3F4 0 0 18700 81 51800 67.6 1.2 LR_open
78 7 MA1549.1 POU6F1 MA1549.1 RTAATGAGVN POU6F1 0 0 18100 78.5 49600 64.7 1.21 LR_open
79 6 MA1607.1 Foxl2 MA1607.1 DDWATGTAAACANN Foxl2 0 0 20800 90.2 60700 79.2 1.14 LR_open
80 16 MA0084.1 SRY MA0084.1 NWWAACAAT SRY 0 0 21500 93.4 64000 83.6 1.12 LR_open
81 17 MA0602.1 Arid5a MA0602.1 SYAATATTGVDANH Arid5a 0 0 19600 84.9 55600 72.6 1.17 LR_open
82 7 MA0706.1 MEOX2 MA0706.1 DSTAATTAWN MEOX2 0 0 18100 78.4 49700 64.9 1.21 LR_open
83 7 MA0675.1 NKX6-2 MA0675.1 NYMATTAA NKX6-2 0 0 20600 89.4 60000 78.3 1.14 LR_open
84 14 MA0465.2 CDX2 MA0465.2 NDGCAATAAAWN CDX2 0 0 20600 89.2 59900 78.1 1.14 LR_open
85 7 MA1502.1 HOXB8 MA1502.1 GYMATTAM HOXB8 0 0 16200 70.5 43100 56.2 1.25 LR_open
86 6 MA0047.3 FOXA2 MA0047.3 RWGTAAACANN FOXA2 0 0 21800 94.4 65400 85.4 1.11 LR_open
87 6 MA0481.3 FOXP1 MA0481.3 NDGTAAACANH FOXP1 0 0 21400 92.7 63600 82.9 1.12 LR_open
88 7 MA1481.1 DRGX MA1481.1 YYAATTAN DRGX 0 0 18900 81.9 53100 69.3 1.18 LR_open
89 18 MA1603.1 Dmrt1 MA1603.1 GHTACAAAGTADC Dmrt1 0 0 20000 86.9 57800 75.4 1.15 LR_open
90 19 MA0495.3 MAFF MA0495.3 DWGTCAGCATTTTWHN MAFF 0 0 21300 92.4 63300 82.6 1.12 LR_open
91 7 MA0910.2 HOXD8 MA0910.2 GYMATTAM HOXD8 2.01084717857387e-321 2.01084717857387e-321 15900 68.9 42000 54.8 1.26 LR_open
92 7 MA0027.2 EN1 MA0027.2 SYAATTAV EN1 5.41001882196165e-319 2.46044691628941e-321 20700 90 60900 79.5 1.13 LR_open
93 20 MA0905.1 HOXC10 MA0905.1 GTCRTAAAAH HOXC10 2.05000188100679e-318 9.19950232556401e-321 19300 83.8 55000 71.7 1.17 LR_open
94 7 MA0718.1 RAX MA0718.1 RYYAATTARH RAX 3.58000001561162e-316 1.5900020614463e-318 19300 83.7 54900 71.6 1.17 LR_open
95 21 MA0025.2 NFIL3 MA0025.2 NRTTATGYAATNN NFIL3 9.99999998481684e-316 4.39000053349656e-318 17100 74.1 46400 60.5 1.22 LR_open
96 7 MA0716.1 PRRX1 MA0716.1 YYAATTAR PRRX1 1.69000000005259e-314 7.32999991728063e-317 20700 89.8 60800 79.3 1.13 LR_open
97 7 MA0720.1 Shox2 MA0720.1 YYAATTAR Shox2 1.94000000001886e-313 8.35000002412995e-316 21100 91.6 62600 81.7 1.12 LR_open
98 7 MA0158.2 HOXA5 MA0158.2 GYMATTAS HOXA5 1.40999999999996e-311 6.01000000011395e-314 14000 60.5 35500 46.3 1.31 LR_open
99 6 MA1683.1 FOXA3 MA1683.1 DWGTAAACANN FOXA3 1.38e-309 5.80999999999765e-312 21300 92.5 63600 83 1.11 LR_open
100 22 MA1487.2 FOXE1 MA1487.2 VYTAAAYAAACAAH FOXE1 3.88e-308 1.61999999999998e-310 17000 73.8 46300 60.5 1.22 LR_open
101 7 MA0704.1 Lhx4 MA0704.1 YTAATTAR Lhx4 2.54e-304 1.05e-306 19400 84 55400 72.2 1.16 LR_open
102 6 MA1606.1 Foxf1 MA1606.1 DWRTAAACANN Foxf1 2.59e-300 1.06e-302 18800 81.3 53000 69.2 1.18 LR_open
103 7 MA0644.2 ESX1 MA0644.2 YYAATTAN ESX1 8.19999999999999e-297 3.32e-299 20200 87.6 58800 76.8 1.14 LR_open
104 6 MA1103.2 FOXK2 MA1103.2 DDGTAAACANN FOXK2 1.66e-296 6.67e-299 20700 89.9 61100 79.8 1.13 LR_open
105 23 MA1480.1 DPRX MA1480.1 AGATAATCCN DPRX 1.78e-296 7.06e-299 21100 91.5 62800 81.9 1.12 LR_open
106 7 MA0899.1 HOXA10 MA0899.1 DGYMATAAAAH HOXA10 1.98e-296 7.78e-299 18400 79.7 51600 67.3 1.18 LR_open
107 16 MA1152.1 SOX15 MA1152.1 CYWTTGTTHW SOX15 2.79e-296 1.09e-298 21600 93.8 65200 85.1 1.1 LR_open
108 7 MA0882.1 DLX6 MA0882.1 VYAATTAN DLX6 1.82e-293 7.03e-296 21200 92.2 63500 82.9 1.11 LR_open
109 7 MA0601.1 Arid3b MA0601.1 ATATTAATWAN Arid3b 5.02e-289 1.92e-291 16000 69.5 43100 56.2 1.24 LR_open
110 7 MA0658.1 LHX6 MA0658.1 RCTAATTARY LHX6 8.62e-289 3.27e-291 18500 80.1 52100 67.9 1.18 LR_open
111 24 MA1124.1 ZNF24 MA1124.1 CATTCATTCATTC ZNF24 9.99999999999999e-287 3.77e-289 14600 63.3 38100 49.7 1.27 LR_open
112 14 MA0650.3 Hoxa13 MA0650.3 NNCCAATAAAAN Hoxa13 6.55e-286 2.44e-288 19100 82.7 54500 71.1 1.16 LR_open
113 21 MA1636.1 CEBPG MA1636.1 NDATGATGCAATMHH CEBPG 9.44999999999999e-286 3.49e-288 17500 75.8 48400 63.1 1.2 LR_open
114 7 MA0700.2 LHX2 MA0700.2 DDCCAATTADN LHX2 1.93e-285 7.07e-288 18100 78.6 50800 66.3 1.19 LR_open
115 6 MA0031.1 FOXD1 MA0031.1 GTAAACAW FOXD1 2.76e-283 1e-285 17300 75.2 47900 62.5 1.2 LR_open
116 7 MA0654.1 ISX MA0654.1 YYAATTAR ISX 1.07e-282 3.84e-285 16700 72.4 45600 59.5 1.22 LR_open
117 7 MA0715.1 PROP1 MA0715.1 TAATYWAATTA PROP1 2.84e-282 1.01e-284 13300 57.8 33900 44.2 1.31 LR_open
118 7 MA0674.1 NKX6-1 MA0674.1 NTMATTAA NKX6-1 2.18e-280 7.7e-283 18500 80 52200 68.1 1.18 LR_open
119 7 MA0880.1 Dlx3 MA0880.1 NYAATTAN Dlx3 1.49e-277 5.22e-280 19600 84.9 56700 74 1.15 LR_open
120 25 MA1104.2 GATA6 MA1104.2 HWWTCTTATCTNH GATA6 1.54e-275 5.34e-278 21200 92.1 63700 83.1 1.11 LR_open
121 7 MA0661.1 MEOX1 MA0661.1 VSTAATTAHC MEOX1 2.32e-275 8e-278 20100 87.1 58700 76.6 1.14 LR_open
122 7 MA0881.1 Dlx4 MA0881.1 VYAATTAN Dlx4 2.37e-275 8.11e-278 20900 90.6 62200 81.2 1.12 LR_open
123 6 MA0033.2 FOXL1 MA0033.2 RTAAACA FOXL1 4.31e-275 1.46e-277 20800 90.4 62000 80.9 1.12 LR_open
124 7 MA0612.2 EMX1 MA0612.2 BTAATTAS EMX1 8.21e-275 2.76e-277 13200 57.2 33600 43.8 1.3 LR_open
125 25 MA0035.4 GATA1 MA0035.4 NHCTAATCTDH GATA1 1.45e-273 4.84e-276 21600 93.8 65600 85.5 1.1 LR_open
126 6 MA0042.2 FOXI1 MA0042.2 GTAAACA FOXI1 5.53e-273 1.83e-275 19900 86.4 58100 75.8 1.14 LR_open
127 7 MA0707.2 MNX1 MA0707.2 VYRATTAK MNX1 4.31e-272 1.41e-274 15700 68 42100 55 1.24 LR_open
128 26 MA0108.2 TBP MA0108.2 STATAAAWRSVVVBN TBP 1.57e-271 5.1e-274 19300 83.5 55500 72.4 1.15 LR_open
129 7 MA0903.1 HOXB3 MA0903.1 NNYMATTARN HOXB3 6.84e-269 2.21e-271 15400 67 41400 54 1.24 LR_open
130 6 MA0848.1 FOXO4 MA0848.1 GTAAACA FOXO4 1.23e-268 3.94e-271 20200 87.6 59300 77.4 1.13 LR_open
131 11 MA0497.1 MEF2C MA0497.1 DDDCYAAAAATAGMW MEF2C 1.23e-267 3.9e-270 17400 75.6 48600 63.4 1.19 LR_open
132 7 MA0721.1 UNCX MA0721.1 YYAATTAV UNCX 1.94e-267 6.12e-270 20600 89.4 61100 79.7 1.12 LR_open
133 27 6-TTAAAA STREME-6 6-TTAAAA TTAAAA TTAAAA 1.28e-265 4.01e-268 22000 95.3 67300 87.8 1.08 LR_open
134 9 MA0611.2 Dux MA0611.2 NTGATTBAATCAVWNN Dux 1.96e-265 6.11e-268 9990 43.3 23600 30.8 1.41 LR_open
135 7 MA0725.1 VSX1 MA0725.1 YTAATTAN VSX1 2.13e-263 6.57e-266 21900 95 67100 87.5 1.09 LR_open
136 6 MA0157.3 Foxo3 MA0157.3 NDGTAAACARNN Foxo3 5.67e-263 1.74e-265 22000 95.5 67600 88.2 1.08 LR_open
137 6 MA0851.1 Foxj3 MA0851.1 NDAADGTAAACAAANNM Foxj3 1.17e-262 3.57e-265 15300 66.5 41100 53.7 1.24 LR_open
138 7 MA1495.1 HOXA1 MA1495.1 STAATTAS HOXA1 2.74e-262 8.28e-265 14700 63.8 39000 50.9 1.25 LR_open
139 21 MA0102.4 CEBPA MA0102.4 NDATTGCACAATHN CEBPA 7.89e-260 2.37e-262 20600 89.3 61200 79.8 1.12 LR_open
140 7 MA0888.1 EVX2 MA0888.1 VVTAATTAVB EVX2 1.31e-259 3.89e-262 19400 84 56200 73.3 1.15 LR_open
141 7 MA0879.2 DLX1 MA0879.2 VYAATTAN DLX1 7.27e-259 2.15e-261 19400 84.3 56400 73.5 1.15 LR_open
142 16 MA0868.2 SOX8 MA0868.2 MGAACAATRG SOX8 1.43e-255 4.21e-258 22200 96.2 68600 89.5 1.08 LR_open
143 7 MA0726.1 VSX2 MA0726.1 CTAATTAN VSX2 1.66e-254 4.84e-257 22000 95.3 67500 88.1 1.08 LR_open
144 7 MA1505.1 HOXC8 MA1505.1 KTAATTAM HOXC8 1.86e-254 5.38e-257 14500 62.9 38400 50.2 1.25 LR_open
145 7 MA0068.2 PAX4 MA0068.2 CTAATTAG PAX4 4.56e-254 1.31e-256 21300 92.2 64100 83.7 1.1 LR_open
146 25 MA0036.3 GATA2 MA0036.3 NBCTTATCTNH GATA2 1.93e-253 5.51e-256 20400 88.4 60300 78.7 1.12 LR_open
147 7 MA0630.1 SHOX MA0630.1 HTAATTRR SHOX 1.13e-251 3.2e-254 18600 80.8 53400 69.7 1.16 LR_open
148 14 MA1125.1 ZNF384 MA1125.1 DNWMAAAAAAAA ZNF384 1.41e-250 3.96e-253 14500 62.9 38500 50.3 1.25 LR_open
149 7 MA0890.1 GBX2 MA0890.1 RSYAATTARN GBX2 6.38e-248 1.79e-250 18600 80.8 53400 69.7 1.16 LR_open
150 1 MA0591.1 Bach1::Mafk MA0591.1 RSSATGACTCAGCAB Bach1::Mafk 1.88e-247 5.22e-250 4730 20.5 8800 11.5 1.79 LR_open
151 22 MA1489.1 FOXN3 MA1489.1 GTAAACAA FOXN3 2.99e-247 8.26e-250 18700 81.2 53800 70.2 1.16 LR_open
152 7 MA0634.1 ALX3 MA0634.1 YYYAATTANV ALX3 8.81999999999999e-247 2.42e-249 20300 87.9 60000 78.2 1.12 LR_open
153 7 MA0125.1 Nobox MA0125.1 TAATTRSY Nobox 4.26e-246 1.16e-248 17800 77 50200 65.5 1.18 LR_open
154 22 MA0847.3 FOXD2 MA0847.3 SYTAARYAAACA FOXD2 2.43e-245 6.57e-248 16200 70.2 44500 58.1 1.21 LR_open
155 7 MA0876.1 BSX MA0876.1 SYVATTAV BSX 5.37e-245 1.45e-247 21100 91.5 63500 82.9 1.1 LR_open
156 7 MA1476.2 Dlx5 MA1476.2 NDGCAATTAGNN Dlx5 6.97e-244 1.86e-246 20800 90.2 62300 81.3 1.11 LR_open
157 7 MA0635.1 BARHL2 MA0635.1 VHTAAAYGRT BARHL2 7.5e-244 1.99e-246 19800 85.8 58100 75.8 1.13 LR_open
158 7 MA0904.2 HOXB5 MA0904.2 STAATTAS HOXB5 1.9e-243 5e-246 15800 68.5 43100 56.2 1.22 LR_open
159 28 MA1657.1 ZNF652 MA1657.1 BAAAGRGTTAAN ZNF652 4.08e-243 1.07e-245 17900 77.6 50800 66.2 1.17 LR_open
160 7 MA0662.1 MIXL1 MA0662.1 NBYAATTAVN MIXL1 1.08e-242 2.82e-245 20600 89.2 61300 80 1.12 LR_open
161 20 MA0908.1 HOXD11 MA0908.1 RTCGTAAAAH HOXD11 3.5e-242 9.07e-245 13100 56.8 34000 44.3 1.28 LR_open
162 7 MA0887.1 EVX1 MA0887.1 VVTAATTABS EVX1 1.07e-241 2.74e-244 17100 74.1 47700 62.3 1.19 LR_open
163 9 MA0755.1 CUX2 MA0755.1 TRATCGATAW CUX2 3.37e-241 8.62e-244 17100 74 47700 62.3 1.19 LR_open
164 7 MA0709.1 Msx3 MA0709.1 SCAATTAN Msx3 8.72e-241 2.22e-243 16900 73.1 47000 61.3 1.19 LR_open
165 9 MA0122.3 Nkx3-2 MA0122.3 WWAAMCACTTAAN Nkx3-2 3.22e-239 8.15e-242 19600 85 57400 74.9 1.14 LR_open
166 20 MA0911.1 Hoxa11 MA0911.1 RGTCGTAAAANT Hoxa11 1.04e-235 2.62e-238 19200 83.2 55800 72.8 1.14 LR_open
167 7 MA1518.2 Lhx1 MA1518.2 NNNTGCTAATTAGCANNN Lhx1 2.81e-235 7.02e-238 19100 82.9 55600 72.5 1.14 LR_open
168 7 MA0892.1 GSX1 MA0892.1 NCYMATTAVN GSX1 6e-235 1.49e-237 15800 68.6 43400 56.6 1.21 LR_open
169 21 MA0043.3 HLF MA0043.3 NNRTTATGCAACHN HLF 2.43e-234 5.98e-237 16200 70.1 44600 58.2 1.2 LR_open
170 16 MA0077.1 SOX9 MA0077.1 CYATTGTTY SOX9 1.4e-231 3.43e-234 22300 96.6 69400 90.5 1.07 LR_open
171 7 MA0648.1 GSC MA0648.1 VYTAATCCSY GSC 2.32e-231 5.66e-234 21500 93.3 65600 85.6 1.09 LR_open
172 7 MA0885.2 Dlx2 MA0885.2 NDGCAATTAGNN Dlx2 7.65e-231 1.85e-233 21600 93.5 65800 85.9 1.09 LR_open
173 7 MA0717.1 RAX2 MA0717.1 YYAATTAV RAX2 1.37e-230 3.29e-233 18200 79.1 52300 68.2 1.16 LR_open
174 25 MA1970.1 TRPS1 MA1970.1 NHTCTTATCTNH TRPS1 5.23e-229 1.25e-231 21800 94.7 67100 87.6 1.08 LR_open
175 7 MA0909.3 Hoxd13 MA0909.3 NNCAATAAAW Hoxd13 6.14e-228 1.46e-230 16800 73 47200 61.5 1.19 LR_open
176 6 MA0480.2 Foxo1 MA0480.2 NDGTAAACANN Foxo1 3.35e-227 7.94e-230 21700 93.9 66300 86.6 1.08 LR_open
177 7 MA0889.1 GBX1 MA0889.1 VCYAATTASY GBX1 4.49e-227 1.06e-229 17800 77.1 50600 66 1.17 LR_open
178 7 MA0724.1 VENTX MA0724.1 AMCGATTAR VENTX 3.68e-226 8.63e-229 15800 68.7 43600 56.9 1.21 LR_open
179 7 MA0701.2 LHX9 MA0701.2 CYAATTAR LHX9 6.48e-225 1.51e-227 12900 55.8 33500 43.7 1.28 LR_open
180 7 MA0666.2 MSX1 MA0666.2 SCAATTAR MSX1 5.78e-224 1.34e-226 18000 78.2 51600 67.4 1.16 LR_open
181 16 MA0143.4 SOX2 MA0143.4 DNACAATGGNN SOX2 4.74e-223 1.09e-225 22000 95.5 68100 88.9 1.07 LR_open
182 29 5-AACMAA STREME-5 5-AACMAA AACMAA AACMAA 2.3e-219 5.26e-222 18500 80.1 53300 69.6 1.15 LR_open
183 6 MA0613.1 FOXG1 MA0613.1 RTAAACAW FOXG1 1.12e-217 2.55e-220 12800 55.6 33500 43.7 1.27 LR_open
184 7 MA1530.1 NKX6-3 MA1530.1 VYCATTAWW NKX6-3 8.34e-216 1.89e-218 14100 61.1 37800 49.3 1.24 LR_open
185 7 MA1463.1 ARGFX MA1463.1 DCTAATTARM ARGFX 6.5e-215 1.46e-217 12800 55.4 33400 43.6 1.27 LR_open
186 7 MA0132.2 PDX1 MA0132.2 VYAATTAR PDX1 9.70999999999999e-215 2.18e-217 15800 68.7 43900 57.2 1.2 LR_open
187 30 MA1479.1 DMRTC2 MA1479.1 AATTGMTACATT DMRTC2 1.63e-213 3.63e-216 19400 84.4 57300 74.7 1.13 LR_open
188 7 MA0875.1 BARX1 MA0875.1 VCMATTAV BARX1 4.82e-212 1.07e-214 17100 74 48300 63.1 1.17 LR_open
189 6 MA0852.2 FOXK1 MA0852.2 NRDGTAAACAAGNN FOXK1 8.24e-211 1.82e-213 19500 84.6 57600 75.1 1.13 LR_open
190 7 MA1519.1 LHX5 MA1519.1 STAATTAV LHX5 7.63e-210 1.67e-212 12500 54.3 32700 42.7 1.27 LR_open
191 7 MA0708.2 MSX2 MA0708.2 SCAATTAV MSX2 1.13e-209 2.47e-212 18300 79.2 52800 68.8 1.15 LR_open
192 9 MA0898.1 Hmx3 MA0898.1 ASAAGCAATTAAWRRAT Hmx3 1.8e-209 3.9e-212 16400 71.2 46100 60.1 1.19 LR_open
193 6 MA0614.1 Foxj2 MA0614.1 RTAAACAA Foxj2 2.38e-209 5.14e-212 15000 65.2 41100 53.7 1.21 LR_open
194 7 MA0712.2 OTX2 MA0712.2 NDRGGATTARNN OTX2 2.47e-209 5.31e-212 20500 88.8 61500 80.2 1.11 LR_open
195 25 MA0037.4 Gata3 MA0037.4 NHTCTTATCTNH Gata3 1.47e-208 3.14e-211 21300 92.4 65100 84.9 1.09 LR_open
196 7 MA0891.1 GSC2 MA0891.1 NYTAATCCBH GSC2 1.12e-206 2.38e-209 21900 95 67800 88.5 1.07 LR_open
197 7 MA0912.2 HOXD3 MA0912.2 CTAATTAC HOXD3 1.75e-205 3.71e-208 10900 47.3 27600 36 1.32 LR_open
198 7 MA0894.1 HESX1 MA0894.1 GHTAATTRRH HESX1 2.09e-205 4.41e-208 16800 72.9 47500 62 1.18 LR_open
199 14 MA0913.2 HOXD9 MA0913.2 GYMATAAAAH HOXD9 1.02e-202 2.14e-205 15100 65.7 41700 54.4 1.21 LR_open
200 7 MA0699.1 LBX2 MA0699.1 NCYAATTARN LBX2 2.03e-202 4.22e-205 20200 87.7 60600 79.1 1.11 LR_open
201 31 MA0050.3 Irf1 MA0050.3 ANTGAAACTGAAASH Irf1 5.56e-201 1.15e-203 21300 92.5 65200 85.1 1.09 LR_open
202 7 MA1498.2 HOXA7 MA1498.2 SYMATTAV HOXA7 1.02e-198 2.11e-201 14800 64.3 40700 53.1 1.21 LR_open
203 7 MA1500.1 HOXB6 MA1500.1 BTAATKRC HOXB6 6.93e-198 1.42e-200 17700 76.9 51000 66.6 1.15 LR_open
204 7 MA1497.1 HOXA6 MA1497.1 BGYMATTANN HOXA6 2.33e-196 4.77e-199 21500 93.2 66000 86.2 1.08 LR_open
205 7 MA1499.1 HOXB4 MA1499.1 RTMATTAR HOXB4 7.31e-195 1.49e-197 11900 51.6 30900 40.4 1.28 LR_open
206 7 MA0895.1 HMBOX1 MA0895.1 MYTAGTTAMS HMBOX1 1.39e-193 2.81e-196 22300 96.6 69800 91.1 1.06 LR_open
207 21 MA0836.2 CEBPD MA0836.2 NRTTGCACAAYHN CEBPD 1.39e-190 2.79e-193 18000 78.2 52300 68.3 1.15 LR_open
208 7 MA1608.1 Isl1 MA1608.1 NNCCATTAGNN Isl1 5.67e-188 1.14e-190 20800 90.3 63300 82.6 1.09 LR_open
209 73 MA0682.2 PITX1 MA0682.2 YTAATCCH PITX1 4.77e-187 9.52e-190 14700 63.6 40400 52.7 1.21 LR_open
210 6 MA0849.1 FOXO6 MA0849.1 GTAAACA FOXO6 3.36e-186 6.67e-189 16800 72.7 47800 62.4 1.17 LR_open
211 32 MA1974.1 ZNF211 MA1974.1 HWYATATACCAYRYW ZNF211 6.74e-186 1.33e-188 13300 57.7 35800 46.8 1.24 LR_open
212 9 MA0754.2 CUX1 MA0754.2 TAATCGATAM CUX1 3.09e-184 6.08e-187 14500 63 40000 52.2 1.21 LR_open
213 21 MA0833.2 ATF4 MA0833.2 DDATGATGCAATMN ATF4 3.66e-184 7.17e-187 14000 60.8 38300 50 1.22 LR_open
214 31 MA1623.1 Stat2 MA1623.1 RGAAACAGAAASH Stat2 1.88e-183 3.66e-186 21800 94.5 67700 88.3 1.07 LR_open
215 7 MA0705.1 Lhx8 MA0705.1 CTAATTAV Lhx8 1.05e-181 2.04e-184 15000 65 41600 54.3 1.2 LR_open
216 33 MA0514.2 Sox3 MA0514.2 DNACAATGGNN Sox3 1.27e-181 2.45e-184 19500 84.6 58200 75.9 1.12 LR_open
217 7 MA1496.1 HOXA4 MA1496.1 RTMATTAV HOXA4 3.79e-181 7.28e-184 17900 77.8 52200 68.1 1.14 LR_open
218 34 MA1562.1 SOX14 MA1562.1 CCGAACAATG SOX14 1.08e-179 2.06e-182 18400 79.9 54000 70.5 1.13 LR_open
219 7 MA0642.2 EN2 MA0642.2 VSYAATTA EN2 1.17e-178 2.23e-181 15600 67.5 43700 57 1.18 LR_open
220 35 MA0151.1 Arid3a MA0151.1 ATYAAA Arid3a 2.29e-177 4.34e-180 12700 55.2 34100 44.5 1.24 LR_open
221 36 MA0769.2 TCF7 MA0769.2 NNCTTTGAWVT TCF7 2.33e-177 4.4e-180 21800 94.5 67700 88.3 1.07 LR_open
222 7 MA0853.1 Alx4 MA0853.1 CGCRYTAATTARYHNNY Alx4 4.89e-176 9.19e-179 12700 55.2 34100 44.5 1.24 LR_open
223 33 MA0867.2 SOX4 MA0867.2 RAACAAAGRV SOX4 8.19e-176 1.53e-178 19100 82.8 56700 73.9 1.12 LR_open
224 7 MA0900.2 HOXA2 MA0900.2 STAATTAS HOXA2 2.07e-175 3.85e-178 10000 43.4 25400 33.1 1.31 LR_open
225 16 MA1120.1 SOX13 MA1120.1 DVACAATGGNN SOX13 3.28e-173 6.08e-176 19600 85 58700 76.6 1.11 LR_open
226 7 MA1504.1 HOXC4 MA1504.1 VTMATTAN HOXC4 1.15e-171 2.12e-174 14100 61.1 38700 50.6 1.21 LR_open
227 7 MA0854.1 Alx1 MA0854.1 CGMRYTAATTARTNMNY Alx1 2.33e-171 4.28e-174 11700 50.8 30900 40.3 1.26 LR_open
228 37 MA0914.1 ISL2 MA0914.1 GCAMTTAR ISL2 9.85e-171 1.8e-173 21900 94.9 68300 89.1 1.07 LR_open
229 8 MA1962.1 POU2F1::SOX2 MA1962.1 MATTTRCATMACAATRG POU2F1::SOX2 1.19e-169 2.16e-172 8690 37.7 21400 27.9 1.35 LR_open
230 7 MA0075.3 PRRX2 MA0075.3 CTAATTAN PRRX2 1.67e-169 3.03e-172 10400 44.9 26600 34.7 1.3 LR_open
231 33 MA1563.2 SOX18 MA1563.2 AACAATDV SOX18 1.25e-167 2.26e-170 19400 84 57900 75.5 1.11 LR_open
232 6 MA0850.1 FOXP3 MA0850.1 RTAAACA FOXP3 3.6e-167 6.46e-170 22200 96.4 70000 91.3 1.06 LR_open
233 7 MA0618.1 LBX1 MA0618.1 TTAATTAG LBX1 1.09e-166 1.94e-169 13300 57.6 36200 47.2 1.22 LR_open
234 18 MA0442.2 SOX10 MA0442.2 NDAACAAAGVN SOX10 1.89e-166 3.36e-169 19700 85.5 59200 77.3 1.11 LR_open
235 38 MA0606.2 Nfat5 MA0606.2 NNATGGAAAAWN Nfat5 7.17e-165 1.27e-167 21000 91.1 64500 84.2 1.08 LR_open
236 16 MA0078.2 Sox17 MA0078.2 NNAGAACAATGGNN Sox17 6.45e-164 1.14e-166 19000 82.3 56400 73.6 1.12 LR_open
237 25 MA0482.2 GATA4 MA0482.2 NNCCTTATCTNH GATA4 2.31e-163 4.06e-166 20000 86.6 60300 78.7 1.1 LR_open
238 9 MA0897.1 Hmx2 MA0897.1 ASAAGCAATTAAHVVRT Hmx2 7.77e-163 1.36e-165 15200 65.9 42800 55.8 1.18 LR_open
239 22 MA0040.1 Foxq1 MA0040.1 HATTGTTTATW Foxq1 1.36e-161 2.38e-164 9510 41.3 24100 31.4 1.31 LR_open
240 7 MA0893.2 GSX2 MA0893.2 SYMATTAR GSX2 3.85e-158 6.68e-161 20100 87.2 61000 79.5 1.1 LR_open
241 14 MA0878.3 CDX1 MA0878.3 GGYMATAAAA CDX1 2.03e-157 3.52e-160 11300 48.8 29700 38.8 1.26 LR_open
242 36 MA0523.1 TCF7L2 MA0523.1 DRASATCAAAGRVA TCF7L2 7.5e-156 1.29e-158 17000 73.6 49200 64.2 1.15 LR_open
243 39 MA1729.1 ZNF680 MA1729.1 GNCCAAGAAGAATDA ZNF680 1.82e-152 3.12e-155 17200 74.5 50100 65.4 1.14 LR_open
244 4 MA0683.1 POU4F2 MA0683.1 RTGCATAATTAATGAG POU4F2 2.35e-152 4.02e-155 5570 24.2 12500 16.3 1.48 LR_open
245 40 MA1960.1 MGA::EVX1 MA1960.1 RGGTGWTAATKD MGA::EVX1 5.34e-145 9.09e-148 18700 81 55700 72.7 1.11 LR_open
246 9 MA0896.1 Hmx1 MA0896.1 VSVAGCAATTAAWGVDB Hmx1 9.15e-145 1.55e-147 15600 67.6 44600 58.1 1.16 LR_open
247 41 MA0877.3 BARHL1 MA0877.3 AMCGTTTA BARHL1 1.46e-143 2.47e-146 19900 86.2 60300 78.7 1.09 LR_open
248 20 MA0906.1 HOXC12 MA0906.1 RGTCGTAAAAH HOXC12 3.43e-142 5.77e-145 10200 44 26600 34.7 1.27 LR_open
249 19 MA0117.2 Mafb MA0117.2 AWWNTGCTGACD Mafb 8.45e-141 1.41e-143 20000 86.6 60800 79.3 1.09 LR_open
250 20 MA0907.1 HOXC13 MA0907.1 BCTCGTAAAAH HOXC13 8.53e-141 1.42e-143 12500 54.2 34200 44.7 1.21 LR_open
251 23 MA0711.1 OTX1 MA0711.1 HTAATCCS OTX1 6.36e-140 1.06e-142 18500 80.2 55100 72 1.11 LR_open
252 42 MA1709.1 ZIM3 MA1709.1 RVMAACAGAAACCYM ZIM3 4.8e-137 7.93e-140 16900 73.2 49300 64.4 1.14 LR_open
253 43 MA0629.1 Rhox11 MA0629.1 ANKNCGCTGTWAWDVRW Rhox11 1.46e-135 2.41e-138 19900 86.2 60600 79 1.09 LR_open
254 7 MA1577.1 TLX2 MA1577.1 BYAATTAR TLX2 2.85e-135 4.68e-138 9650 41.8 25100 32.8 1.28 LR_open
255 9 MA0757.1 ONECUT3 MA0757.1 AAAAAATCRATAAH ONECUT3 8.61e-133 1.41e-135 7610 33 18900 24.6 1.34 LR_open
256 7 MA0874.1 Arx MA0874.1 VTBCRYTAATTARTKSW Arx 1.82e-132 2.97e-135 9710 42.1 25400 33.2 1.27 LR_open
257 23 MA0714.1 PITX3 MA0714.1 NYTAATCCC PITX3 6.55e-130 1.06e-132 22200 96.4 70500 92 1.05 LR_open
258 7 MA0467.2 Crx MA0467.2 NDGGATTANN Crx 6.64e-130 1.07e-132 18300 79.2 54600 71.2 1.11 LR_open
259 12 MA1126.1 FOS::JUN MA1126.1 DRTGACGTCATHNDTN FOS::JUN 2.81e-129 4.52e-132 18900 82.2 57100 74.5 1.1 LR_open
260 9 MA0780.1 PAX3 MA0780.1 TAATYRATTA PAX3 6.45e-129 1.03e-131 7540 32.7 18800 24.5 1.34 LR_open
261 7 MA1507.1 HOXD4 MA1507.1 VTMATTAD HOXD4 7.96e-126 1.27e-128 8560 37.1 22000 28.7 1.29 LR_open
262 44 MA1119.1 SIX2 MA1119.1 NNCTGAAACCTGATMY SIX2 1.71e-125 2.72e-128 21000 90.9 65100 84.9 1.07 LR_open
263 9 MA0070.1 PBX1 MA0070.1 HCATCAATCAAW PBX1 1.48e-124 2.34e-127 11300 48.9 30600 39.9 1.22 LR_open
264 12 MA0018.4 CREB1 MA0018.4 NNRTGATGTCAYN CREB1 1.05e-123 1.66e-126 22100 95.7 69900 91.2 1.05 LR_open
265 45 MA0884.2 DUXA MA0884.2 YTRATTWAATYAR DUXA 1.72e-122 2.71e-125 5330 23.1 12400 16.1 1.43 LR_open
266 44 MA1118.1 SIX1 MA1118.1 GWAACCTGAKM SIX1 2.79e-120 4.37e-123 19600 85.2 60000 78.3 1.09 LR_open
267 46 MA0144.2 STAT3 MA0144.2 YTTCYKGGAAD STAT3 1.48e-118 2.31e-121 16800 72.6 49400 64.4 1.13 LR_open
268 36 MA0768.2 Lef1 MA0768.2 NNBCCTTTGATSTN Lef1 2.94e-116 4.57e-119 22100 95.7 70000 91.3 1.05 LR_open
269 30 MA1707.1 DMRTA1 MA1707.1 AWTTGWTACAWT DMRTA1 5.54e-115 8.58e-118 18300 79.3 55000 71.8 1.1 LR_open
270 33 MA0095.3 Yy1 MA0095.3 NNCAAAATGGCN Yy1 9.47e-114 1.46e-116 18300 79.5 55200 72 1.1 LR_open
271 23 MA0883.1 Dmbx1 MA0883.1 WDRWNMGGATTADKNNW Dmbx1 3.76e-112 5.78e-115 13400 58.2 38000 49.6 1.17 LR_open
272 47 MA0809.2 TEAD4 MA0809.2 NNACATTCCARN TEAD4 1.04e-109 1.59e-112 21000 91.2 65700 85.8 1.06 LR_open
273 12 MA1150.1 RORB MA1150.1 AWWTRGGTCAH RORB 2.06e-109 3.15e-112 18500 80.4 56100 73.3 1.1 LR_open
274 12 MA1632.1 ATF2 MA1632.1 NNATGABGTCATN ATF2 1.49e-105 2.26e-108 16400 70.9 48300 63.1 1.12 LR_open
275 12 MA1131.1 FOSL2::JUN MA1131.1 GRTGACGTMAT FOSL2::JUN 8.8e-105 1.33e-107 17800 77.3 53700 70 1.1 LR_open
276 48 MA1588.1 ZNF136 MA1588.1 RWATTCTTGGTTGRC ZNF136 7.13e-103 1.08e-105 13500 58.7 38800 50.6 1.16 LR_open
277 19 MA0842.2 NRL MA0842.2 AAWWNTGCTGACG NRL 9.71e-101 1.46e-103 9040 39.2 24100 31.5 1.24 LR_open
278 20 MA0873.1 HOXD12 MA0873.1 RGTCGTAAAAH HOXD12 1.09e-99 1.63e-102 8810 38.2 23400 30.6 1.25 LR_open
279 6 MA0593.1 FOXP2 MA0593.1 RWGTAAACAVR FOXP2 3.58e-99 5.36e-102 7350 31.9 18900 24.7 1.29 LR_open
280 12 MA0843.1 TEF MA0843.1 BRTTACRTAAYM TEF 7.54e-99 1.12e-101 8020 34.8 21000 27.4 1.27 LR_open
281 49 MA0678.1 OLIG2 MA0678.1 AMCATATGKT OLIG2 3.5e-97 5.19e-100 15300 66.3 44800 58.5 1.13 LR_open
282 50 MA0063.2 NKX2-5 MA0063.2 NNCACTCAANN NKX2-5 6.52e-97 9.64e-100 18000 78.2 54600 71.2 1.1 LR_open
283 34 MA1561.1 SOX12 MA1561.1 ACCGAACAATV SOX12 7.77e-97 1.14e-99 17100 74 51200 66.8 1.11 LR_open
284 7 MA0135.1 Lhx3 MA0135.1 WAATTAATTAWYY Lhx3 9.15e-96 1.34e-98 5800 25.2 14300 18.7 1.35 LR_open
285 12 MA1127.1 FOSB::JUN MA1127.1 GATGACGTCAT FOSB::JUN 4.11e-95 6.01e-98 19300 83.9 59500 77.6 1.08 LR_open
286 12 MA1139.1 FOSL2::JUNB MA1139.1 DATGACGTCATH FOSL2::JUNB 3.3e-94 4.81e-97 14400 62.4 41900 54.6 1.14 LR_open
287 25 MA0766.2 GATA5 MA0766.2 SWGATAASRN GATA5 2.74e-93 3.98e-96 12700 55.2 36300 47.4 1.16 LR_open
288 30 MA1478.1 DMRTA2 MA1478.1 AATTGHTACAWT DMRTA2 9.88e-93 1.43e-95 20500 88.9 64000 83.4 1.07 LR_open
289 22 MA0030.1 FOXF2 MA0030.1 BNAASGTAAACAAD FOXF2 1.87e-92 2.7e-95 5410 23.5 13200 17.3 1.36 LR_open
290 20 MA0594.2 HOXA9 MA0594.2 RTCGTWAHNN HOXA9 9.94e-92 1.43e-94 22000 95.6 70300 91.8 1.04 LR_open
291 51 MA0693.3 Vdr MA0693.3 NNGAGTTCANN Vdr 1.62e-91 2.32e-94 17000 73.7 51000 66.6 1.11 LR_open
292 52 MA0520.1 Stat6 MA0520.1 BDBTTCCWSAGAAVY Stat6 2.59e-88 3.69e-91 9180 39.8 25000 32.6 1.22 LR_open
293 21 MA0838.1 CEBPG MA0838.1 ATTRCGCAAY CEBPG 9.71e-88 1.38e-90 6870 29.8 17800 23.2 1.29 LR_open
294 53 MA0782.2 PKNOX1 MA0782.2 NNTGAGTGACAGVNN PKNOX1 5.09e-87 7.22e-90 15900 68.9 47300 61.7 1.12 LR_open
295 47 MA0090.3 TEAD1 MA0090.3 NNACATTCCAGSN TEAD1 1.67e-85 2.36e-88 19500 84.5 60300 78.6 1.07 LR_open
296 38 MA0152.2 Nfatc2 MA0152.2 NNRNAATGGAAANWNH Nfatc2 7.89e-85 1.11e-87 22000 95.4 70300 91.7 1.04 LR_open
297 54 MA0689.1 TBX20 MA0689.1 WAGGTGTGAAR TBX20 3.84e-82 5.39e-85 18700 80.9 57300 74.8 1.08 LR_open
298 25 MA0140.2 GATA1::TAL1 MA0140.2 MTTATCWSNNNNNHVCAG GATA1::TAL1 9.04e-82 1.26e-84 8630 37.4 23400 30.5 1.23 LR_open
299 12 MA0639.1 DBP MA0639.1 NRTTACGTAAYV DBP 4.36e-81 6.08e-84 7230 31.4 19000 24.8 1.26 LR_open
300 55 MA0620.3 MITF MA0620.3 NNNDRTCACGTGAYHNNN MITF 4.44e-79 6.17e-82 15500 67 46100 60.1 1.12 LR_open
301 56 MA0687.1 SPIC MA0687.1 HAAAAGVGGAAGTA SPIC 2.15e-78 2.98e-81 19400 84.3 60300 78.7 1.07 LR_open
302 16 MA0087.2 Sox5 MA0087.2 VRVAACAATGGNN Sox5 1.09e-77 1.5e-80 21100 91.5 66700 87 1.05 LR_open
303 50 MA1523.1 MSANTD3 MA1523.1 STVCACTCAC MSANTD3 2.08e-76 2.87e-79 20800 90.3 65600 85.6 1.05 LR_open
304 7 MA0621.1 mix-a MA0621.1 NDTTAATTAGN mix-a 3.17e-76 4.34e-79 6120 26.6 15800 20.6 1.29 LR_open
305 12 MA1145.1 FOSL2::JUND MA1145.1 NNRTGACGTCAYHSN FOSL2::JUND 4.02e-75 5.5e-78 17100 74 51800 67.6 1.09 LR_open
306 56 MA1952.1 FOXJ2::ELF1 MA1952.1 RTAAACMGGAAGTR FOXJ2::ELF1 6.78e-75 9.24e-78 20300 87.9 63600 82.9 1.06 LR_open
307 57 MA0069.1 PAX6 MA0069.1 TTCACGCWTSANTK PAX6 2.31e-74 3.14e-77 14200 61.6 41900 54.7 1.13 LR_open
308 7 MA1501.1 HOXB7 MA1501.1 GGTAATTAVS HOXB7 2.38e-74 3.23e-77 8060 35 21800 28.5 1.23 LR_open
309 50 MA1994.1 Nkx2-1 MA1994.1 NVCACTTGARHNN Nkx2-1 4.38e-74 5.91e-77 22500 97.5 72600 94.8 1.03 LR_open
310 36 MA1991.1 Hnf1A MA1991.1 NBCCTTTGATSTBN Hnf1A 1.1e-73 1.49e-76 12700 54.9 36700 48 1.14 LR_open
311 73 MA0483.1 Gfi1B MA0483.1 AAATCWCWGCH Gfi1B 4.53e-72 6.08e-75 10800 46.9 30700 40.1 1.17 LR_open
312 16 MA0515.1 Sox6 MA0515.1 CCWTTGTYYY Sox6 2.02e-70 2.7e-73 5940 25.8 15400 20.1 1.28 LR_open
313 49 MA0827.1 OLIG3 MA0827.1 AMCATATGBY OLIG3 4.09e-70 5.44e-73 15700 68 47200 61.5 1.11 LR_open
314 45 MA0468.1 DUX4 MA0468.1 TAAYYYAATCA DUX4 2.33e-69 3.09e-72 5280 22.9 13400 17.5 1.31 LR_open
315 12 MA1129.1 FOSL1::JUN MA1129.1 ATGACGTCAT FOSL1::JUN 9.06e-69 1.2e-71 20000 86.6 62600 81.7 1.06 LR_open
316 12 MA1133.1 JUN::JUNB MA1133.1 KRTGACGTCATN JUN::JUNB 1.45e-68 1.91e-71 20100 87.2 63100 82.3 1.06 LR_open
317 55 MA0626.1 Npas2 MA0626.1 NSCACGTGTN Npas2 4.56e-67 5.99e-70 12300 53.2 35700 46.6 1.14 LR_open
318 19 MA1520.1 MAF MA1520.1 NTGCTGASTCAGCAH MAF 1.85e-65 2.43e-68 10300 44.8 29400 38.4 1.17 LR_open
319 38 MA0624.2 Nfatc1 MA0624.2 NVATGGAAAAWN Nfatc1 2.5e-64 3.27e-67 19000 82.4 59100 77.2 1.07 LR_open
320 53 MA0498.2 MEIS1 MA0498.2 HTGACAD MEIS1 1.46e-63 1.9e-66 21100 91.3 66900 87.3 1.05 LR_open
321 42 MA1953.1 FOXO1::ELF1 MA1953.1 RTMAACAGGAAGTN FOXO1::ELF1 4.9e-63 6.37e-66 20800 90.4 66000 86.2 1.05 LR_open
322 33 MA0869.2 Sox11 MA0869.2 NRGAACAAAGVV Sox11 5.02e-63 6.5e-66 17400 75.4 53300 69.6 1.08 LR_open
323 12 MA1136.1 FOSB::JUNB MA1136.1 RTGACGTCAT FOSB::JUNB 8.9e-62 1.15e-64 19300 83.7 60300 78.7 1.06 LR_open
324 58 MA1112.2 NR4A1 MA1112.2 NNAAAGGTCANN NR4A1 5.29e-61 6.8e-64 18100 78.4 55900 72.9 1.07 LR_open
325 20 MA1506.1 HOXD10 MA1506.1 RGTCGTAAAAH HOXD10 7.92e-61 1.02e-63 5600 24.3 14700 19.1 1.27 LR_open
326 59 MA0631.1 Six3 MA0631.1 DATRGGGTATCAYNWNT Six3 1.02e-60 1.31e-63 11500 49.8 33400 43.5 1.14 LR_open
327 60 MA1975.1 ZNF214 MA1975.1 VWTCATCAABGTCCT ZNF214 7.85e-60 1e-62 18600 80.6 57700 75.3 1.07 LR_open
328 7 MA0702.2 LMX1A MA0702.2 TTAATTAM LMX1A 5.52e-59 7.02e-62 5960 25.8 15800 20.6 1.25 LR_open
329 55 MA0093.3 USF1 MA0093.3 NDGTCATGTGACHN USF1 1.25e-58 1.58e-61 16700 72.4 51100 66.7 1.09 LR_open
330 31 MA0517.1 STAT1::STAT2 MA0517.1 THAGTTTCRKTTTCY STAT1::STAT2 3.23e-57 4.08e-60 11900 51.4 34700 45.3 1.14 LR_open
331 61 MA1125.1 (ZNF384) MEME-2 AAAAAAAAAAAAAAA AAAAAAAAAAAAAAA ZNF384 5.1e-57 6.43e-60 3490 15.2 8490 11.1 1.37 LR_open
332 49 MA0461.2 Atoh1 MA0461.2 RMCATATGBY Atoh1 5.34e-57 6.7e-60 20800 90.1 66000 86.1 1.05 LR_open
333 62 MA0479.1 FOXH1 MA0479.1 BNSAATCCACA FOXH1 4.49e-56 5.62e-59 5480 23.8 14500 18.9 1.26 LR_open
334 21 MA0837.2 CEBPE MA0837.2 KATTGCGCAATM CEBPE 5.07e-56 6.33e-59 3020 13.1 7140 9.32 1.4 LR_open
335 31 MA0772.1 IRF7 MA0772.1 HCGAAARYGAAAVT IRF7 1.93e-55 2.4e-58 8140 35.3 22800 29.7 1.19 LR_open
336 63 MA0596.1 SREBF2 MA0596.1 RTGGGGTGAY SREBF2 1.71e-53 2.12e-56 6690 29 18200 23.8 1.22 LR_open
337 64 MA1720.1 ZNF85 MA1720.1 DHDGAGATTACWKCAK ZNF85 1.79e-53 2.22e-56 16300 70.5 49800 64.9 1.09 LR_open
338 65 MA1105.2 GRHL2 MA1105.2 NRAACAGGTTYN GRHL2 1.64e-52 2.02e-55 19600 85.2 61800 80.7 1.06 LR_open
339 37 MA0124.2 Nkx3-1 MA0124.2 RCCACTTAA Nkx3-1 5.38e-52 6.61e-55 20900 90.4 66400 86.7 1.04 LR_open
340 73 MA0038.2 GFI1 MA0038.2 BMAATCACDGCA GFI1 8.57e-52 1.05e-54 6220 27 16900 22 1.23 LR_open
341 66 MA1592.1 ZNF274 MA1592.1 NRTRTGAGTTCTCGYN ZNF274 2.59e-51 3.16e-54 6160 26.7 16700 21.8 1.23 LR_open
342 67 MA0619.1 LIN54 MA0619.1 DTTTRAATH LIN54 5.32e-49 6.49e-52 5510 23.9 14800 19.3 1.24 LR_open
343 49 MA1108.2 MXI1 MA1108.2 NNCACATGBN MXI1 1.01e-48 1.23e-51 15500 67.4 47500 62 1.09 LR_open
344 68 MA1151.1 RORC MA1151.1 NWAWNTRGGTCA RORC 1.61e-48 1.95e-51 21900 95.1 70700 92.3 1.03 LR_open
345 46 MA1625.1 Stat5b MA1625.1 NNNTTCCCAGAANNN Stat5b 2.08e-45 2.51e-48 18200 79 57000 74.4 1.06 LR_open
346 69 MA0508.3 PRDM1 MA0508.3 YNCTTTCTCTH PRDM1 2.91e-44 3.51e-47 21900 95.1 70800 92.4 1.03 LR_open
347 65 MA0743.2 SCRT1 MA0743.2 NDWKCAACAGGTGKNN SCRT1 1.33e-42 1.59e-45 17600 76.3 54900 71.6 1.07 LR_open
348 7 MA1644.1 NFYC MA1644.1 RDCCAATCASN NFYC 2.96e-42 3.55e-45 21600 93.8 69700 91 1.03 LR_open
349 51 MA1534.1 NR1I3 MA1534.1 RTGAACTTT NR1I3 5.09e-42 6.09e-45 15200 65.9 46600 60.8 1.08 LR_open
350 49 MA1618.1 Ptf1a MA1618.1 NNACAGATGTTNN Ptf1a 1.32e-41 1.57e-44 11900 51.7 35600 46.4 1.11 LR_open
351 19 MA1521.1 MAFA MA1521.1 NTGCTGASTCAGCAN MAFA 5.47e-40 6.49e-43 4220 18.3 11100 14.5 1.26 LR_open
352 20 MA1503.1 HOXB9 MA1503.1 GTCGTAAAAH HOXB9 1.47e-39 1.75e-42 2360 10.2 5670 7.4 1.39 LR_open
353 23 MA0719.1 RHOXF1 MA0719.1 NTRATCCN RHOXF1 2.29e-39 2.71e-42 15100 65.5 46400 60.5 1.08 LR_open
354 55 MA0829.2 SREBF1 MA0829.2 DNATCACSTGATNH SREBF1 2.78e-38 3.27e-41 13800 59.9 42100 54.9 1.09 LR_open
355 47 MA1121.1 TEAD2 MA1121.1 NYACATTCCWNNS TEAD2 2.74e-37 3.22e-40 19500 84.5 61900 80.7 1.05 LR_open
356 7 MA0784.2 POU1F1 MA0784.2 ANCTMATTWGCATAWT POU1F1 1.35e-35 1.58e-38 1960 8.51 4620 6.03 1.41 LR_open
357 70 MA0861.1 TP73 MA0861.1 DRCATGTCNNRACAYGYM TP73 1.96e-35 2.28e-38 1500 6.51 3340 4.35 1.5 LR_open
358 71 MA0684.2 RUNX3 MA0684.2 NHAACCTCAANN RUNX3 2.01e-35 2.34e-38 18000 78.2 56700 74 1.06 LR_open
359 46 MA1624.1 Stat5a MA1624.1 NTTCCAAGAANH Stat5a 6.53e-35 7.59e-38 20000 86.5 63600 83 1.04 LR_open
360 68 MA0494.1 Nr1h3::Rxra MA0494.1 TGACCTNNAGTRACCYYDN Nr1h3::Rxra 1.1e-34 1.28e-37 18200 79 57400 75 1.05 LR_open
361 70 MA0106.3 TP53 MA0106.3 RACATGYCCGGRCATGTY TP53 1.34e-34 1.55e-37 259 1.12 276 0.36 3.12 LR_open
362 12 MA0492.1 JUND MA0492.1 DDDRATGABGTCATN JUND 2.82e-34 3.25e-37 4720 20.5 12900 16.8 1.22 LR_open
363 51 MA1111.1 NR2F2 MA1111.1 NAAAGGTCANR NR2F2 4.35e-34 4.99e-37 21700 94.2 70300 91.7 1.03 LR_open
364 49 MA1524.2 Msgn1 MA1524.2 VRRRACAAATGGTNNN Msgn1 9.29e-34 1.06e-36 14800 64 45500 59.4 1.08 LR_open
365 72 MA1593.1 ZNF317 MA1593.1 WVACAGCAGAYW ZNF317 4.58e-33 5.23e-36 22700 98.6 74500 97.2 1.01 LR_open
366 44 MA2001.1 Six4 MA2001.1 GDAACCTGANH Six4 1.07e-32 1.21e-35 11500 49.9 34700 45.2 1.1 LR_open
367 73 MA0682.2 (PITX1) MEME-3 AAGTGCTGGGATTAC AAGTGCTGGGATTAC PITX1 2.12e-32 2.41e-35 1930 8.36 4600 6 1.39 LR_open
368 14 MA1473.1 CDX4 MA1473.1 GGYMATAAAAC CDX4 5.78e-32 6.55e-35 2590 11.2 6540 8.53 1.32 LR_open
369 70 MA0525.2 TP63 MA0525.2 RACATGTYGKGACATGTC TP63 9e-32 1.02e-34 411 1.78 609 0.79 2.25 LR_open
370 73 MA1547.2 PITX2 MA1547.2 YTAATCCY PITX2 1.58e-29 1.78e-32 1850 8.04 4460 5.82 1.38 LR_open
371 71 MA1989.1 Bcl11B MA1989.1 NNAAACCACAARNN Bcl11B 2.14e-29 2.4e-32 22900 99.5 75600 98.6 1.01 LR_open
372 21 MA0466.3 CEBPB MA0466.3 KATTGCGCAATM CEBPB 3.39e-29 3.8e-32 473 2.05 775 1.01 2.03 LR_open
373 11 MA0773.1 MEF2D MA0773.1 DCTAWAAATAGM MEF2D 3.99e-29 4.46e-32 3500 15.2 9330 12.2 1.25 LR_open
374 49 MA1570.1 TFAP4 MA1570.1 AHCATRTGDT TFAP4 8.52e-29 9.5e-32 6940 30.1 20100 26.2 1.15 LR_open
375 49 MA0826.1 OLIG1 MA0826.1 AMCATATGKT OLIG1 1.35e-28 1.5e-31 6340 27.5 18200 23.7 1.16 LR_open
376 12 MA0488.1 JUN MA0488.1 DDRATGATGTCAT JUN 4.02e-28 4.46e-31 3360 14.6 8960 11.7 1.25 LR_open
377 20 MA0485.2 HOXC9 MA0485.2 GTCGTAAAAH HOXC9 1.4e-27 1.55e-30 1160 5.01 2550 3.33 1.51 LR_open
378 54 MA0800.1 EOMES MA0800.1 RAGGTGTGAAAWN EOMES 1.66e-27 1.83e-30 19500 84.6 62400 81.4 1.04 LR_open
379 73 MA1547.2 (PITX2) STREME-11 11-CTGGGAYTAC 11-CTGGGAYTAC PITX2 1.25e-26 1.37e-29 2780 12 7250 9.46 1.27 LR_open
380 47 MA0808.1 TEAD3 MA0808.1 RCATTCCW TEAD3 1.34e-26 1.47e-29 11000 47.8 33400 43.6 1.1 LR_open
381 74 MA1580.1 ZBTB32 MA1580.1 TGTACAGTAW ZBTB32 9.31e-26 1.02e-28 4260 18.5 11800 15.4 1.2 LR_open
382 65 MA0647.1 GRHL1 MA0647.1 AAAACCGGTTTD GRHL1 2.36e-25 2.57e-28 6950 30.2 20300 26.5 1.14 LR_open
383 63 MA0595.1 SREBF1 MA0595.1 VTCACCCCAY SREBF1 2.79e-25 3.04e-28 4430 19.2 12300 16.1 1.19 LR_open
384 20 MA0651.2 HOXC11 MA0651.2 AGGTCGTAAAAH HOXC11 3.99e-25 4.33e-28 2340 10.1 5990 7.82 1.3 LR_open
385 75 9-CACTTTGGGAG STREME-9 9-CACTTTGGGAG CACTTTGGGAG CACTTTGGGAG 6.84e-25 7.4e-28 325 1.41 481 0.63 2.25 LR_open
386 46 MA0137.3 STAT1 MA0137.3 TTTCYRGGAAA STAT1 7.71e-25 8.32e-28 11300 49 34400 44.9 1.09 LR_open
387 46 MA0518.1 Stat4 MA0518.1 YTTCYRGGAARNVR Stat4 9.74e-25 1.05e-27 9190 39.9 27500 35.9 1.11 LR_open
388 76 TAGAGAYRGGGTTTC MEME-5 TAGAGAYRGGGTTTC TAGAGAYRGGGTTTC TAGAGAYRGGGTTTC 5.75e-24 6.18e-27 460 2 803 1.05 1.91 LR_open
389 42 MA1956.1 FOXO1::FLI1 MA1956.1 GTAAACAGGAAGTK FOXO1::FLI1 7.75e-24 8.3e-27 3970 17.2 11000 14.3 1.2 LR_open
390 46 MA0519.1 Stat5a::Stat5b MA0519.1 DTTTCCMAGAA Stat5a::Stat5b 1.55e-23 1.66e-26 10800 46.7 32700 42.7 1.09 LR_open
391 12 MA0840.1 Creb5 MA0840.1 NATGACGTCAYH Creb5 1.74e-22 1.86e-25 2660 11.6 7050 9.2 1.26 LR_open
392 36 MA1421.1 TCF7L1 MA1421.1 AAAGATCAAAGG TCF7L1 3.78e-22 4.02e-25 3600 15.6 9910 12.9 1.21 LR_open
393 49 MA0817.1 BHLHE23 MA0817.1 AAACATATGBTN BHLHE23 4.49e-22 4.76e-25 2340 10.1 6090 7.95 1.28 LR_open
394 25 MA0029.1 Mecom MA0029.1 AAGAYAAGATAANA Mecom 6.14e-21 6.5e-24 2150 9.32 5570 7.27 1.28 LR_open
395 30 MA0610.1 DMRT3 MA0610.1 MATGTATCAAN DMRT3 1.93e-20 2.03e-23 6940 30.1 20500 26.8 1.12 LR_open
396 77 MA1585.1 ZKSCAN1 MA1585.1 AYAGTAGGTS ZKSCAN1 3.2e-20 3.37e-23 11100 48.1 34000 44.4 1.08 LR_open
397 46 MA0463.2 BCL6 MA0463.2 NYGCTTTCKAGGAAYN BCL6 1.63e-19 1.72e-22 13500 58.4 42000 54.8 1.07 LR_open
398 58 MA1148.1 PPARA::RXRA MA1148.1 AWNTRGGTYAAAGGTCAN PPARA::RXRA 3.42e-19 3.58e-22 10600 46.1 32600 42.5 1.08 LR_open
399 78 MA0164.1 Nr2e3 MA0164.1 CAAGCTT Nr2e3 8.6e-19 8.98e-22 5150 22.4 14900 19.5 1.15 LR_open
400 68 MA0072.1 RORA MA0072.1 NWWAWBTAGGTCAR RORA 2.02e-18 2.1e-21 1970 8.56 5130 6.7 1.28 LR_open
401 79 MA1973.1 (ZKSCAN3) MEME-6 TGTYRCCCAGGCTGG TGTYRCCCAGGCTGG ZKSCAN3 2.27e-18 2.35e-21 383 1.66 685 0.89 1.86 LR_open
402 7 MA0060.3 NFYA MA0060.3 RRCCAATCAGM NFYA 1.02e-17 1.06e-20 14100 61.1 44200 57.7 1.06 LR_open
403 50 MA1645.1 NKX2-2 MA1645.1 NNNCCACTCAANNN NKX2-2 1.57e-17 1.63e-20 17900 77.6 57200 74.6 1.04 LR_open
404 80 MA0019.1 Ddit3::Cebpa MA0019.1 VNRTGCAATMCC Ddit3::Cebpa 5.11e-17 5.28e-20 9860 42.8 30200 39.4 1.09 LR_open
405 54 MA0804.1 TBX19 MA0804.1 DTTMRCACMTAGGTGTGAAW TBX19 4.27e-16 4.39e-19 6420 27.9 19100 24.9 1.12 LR_open
406 7 MA1546.1 PAX3 MA1546.1 YSGTCACGSYWATTAN PAX3 4.4e-16 4.52e-19 12800 55.6 40100 52.3 1.06 LR_open
407 7 MA0703.2 LMX1B MA0703.2 AWTTTAATTAA LMX1B 1.47e-15 1.5e-18 1690 7.34 4400 5.74 1.28 LR_open
408 42 MA1955.1 FOXO1::ELK3 MA1955.1 RWMAACAGGAAGTN FOXO1::ELK3 1.81e-15 1.85e-18 12400 54 38800 50.7 1.06 LR_open
409 47 MA0114.4 HNF4A MA0114.4 DNCAAAGTCCANN HNF4A 2.07e-15 2.11e-18 17800 77.2 57000 74.4 1.04 LR_open
410 11 MA0660.1 MEF2B MA0660.1 RCTAWAAATAGC MEF2B 2.13e-15 2.17e-18 3010 13 8390 10.9 1.19 LR_open
411 51 MA1996.1 Nr1H2 MA1996.1 NNRAGGTCANN Nr1H2 2.69e-15 2.73e-18 15600 67.5 49400 64.4 1.05 LR_open
412 81 MA1596.1 (ZNF460) STREME-14 14-ACCTCAGCCTCC 14-ACCTCAGCCTCC ZNF460 2.93e-15 2.96e-18 309 1.34 544 0.71 1.89 LR_open
413 54 MA0802.1 TBR1 MA0802.1 AGGTGTGAAA TBR1 3.38e-15 3.41e-18 20000 86.9 64800 84.6 1.03 LR_open
414 82 MA0698.1 ZBTB18 MA0698.1 NATCCAGATGTKB ZBTB18 1.23e-14 1.24e-17 3940 17.1 11300 14.8 1.16 LR_open
415 83 MA1714.1 ZNF675 MA1714.1 RGGVHYMGGAGGMCAAAATGD ZNF675 4.09e-13 4.11e-16 11000 47.9 34400 44.9 1.07 LR_open
416 42 MA1950.1 FLI1::FOXI1 MA1950.1 RTAAACAGGAARYN FLI1::FOXI1 8.14e-13 8.16e-16 16700 72.6 53600 69.9 1.04 LR_open
417 79 MA1973.1 (ZKSCAN3) STREME-8 8-CCAGCCTGGGYRAC CCAGCCTGGGYRAC ZKSCAN3 2.85e-12 2.85e-15 329 1.43 633 0.83 1.73 LR_open
418 50 MA1114.1 PBX3 MA1114.1 NNNTGAGTGACAGGBNN PBX3 2.99e-12 2.98e-15 16300 70.6 52000 67.8 1.04 LR_open
419 65 MA0744.2 SCRT2 MA0744.2 NNWGCAACAGGTGDNN SCRT2 3.4e-12 3.38e-15 16700 72.3 53300 69.6 1.04 LR_open
420 84 MA0101.1 REL MA0101.1 BGGRNWTTCC REL 7.78e-12 7.72e-15 20800 90.3 67800 88.5 1.02 LR_open
421 85 MA1107.2 (KLF9) STREME-13 13-ACCACACMCA 13-ACCACACMCA KLF9 1.29e-11 1.28e-14 478 2.07 1030 1.35 1.54 LR_open
422 86 MA1949.1 FLI1::DRGX MA1949.1 ACCGGAAGTAATTAT FLI1::DRGX 1.88e-11 1.86e-14 13600 59.1 43100 56.2 1.05 LR_open
423 87 12-CTCCTGGGCTCAA STREME-12 12-CTCCTGGGCTCAA 12-CTCCTGGGCTCAA CTCCTGGGCTCAA 2.42e-11 2.39e-14 197 0.85 323 0.42 2.03 LR_open
424 58 MA1541.1 NR6A1 MA1541.1 NYCAAGKTCAAGKTCAN NR6A1 4.41e-11 4.34e-14 15700 68.2 50300 65.6 1.04 LR_open
425 47 MA0484.2 HNF4G MA0484.2 DNCAAAGTCCANN HNF4G 1.26e-09 1.24e-12 8880 38.5 27600 36 1.07 LR_open
426 49 MA1467.2 Atoh1 MA1467.2 RVCAGATGGYN Atoh1 2.92e-09 2.85e-12 21000 91 68600 89.5 1.02 LR_open
427 46 MA1116.1 RBPJ MA1116.1 BVTGGGAANN RBPJ 8.46e-09 8.26e-12 19400 84.1 63000 82.2 1.02 LR_open
428 55 MA1995.1 Npas4 MA1995.1 NNTCGTGACHN Npas4 1.54e-08 1.5e-11 4230 18.3 12600 16.4 1.11 LR_open
429 58 MA0160.2 NR4A2 MA0160.2 BWAAAGGTCA NR4A2 1.69e-08 1.64e-11 13100 56.9 41700 54.5 1.05 LR_open
430 88 MA1980.1 ZNF418 MA1980.1 MDGAGGCTAAAAGCA ZNF418 1.8e-08 1.74e-11 3520 15.2 10400 13.5 1.13 LR_open
431 89 MA1594.1 ZNF382 MA1594.1 AGGRGAYATCACYACMGAYCCCAC ZNF382 4.24e-08 4.1e-11 2160 9.35 6120 7.99 1.17 LR_open
432 81 MA1596.1 ZNF460 MA1596.1 GCCTCMGCCTCCCRAG ZNF460 4.47e-08 4.31e-11 234 1.01 454 0.59 1.72 LR_open
433 49 MA0607.2 BHLHA15 MA0607.2 ACCATATGGT BHLHA15 4.65e-08 4.48e-11 4680 20.3 14100 18.4 1.1 LR_open
434 71 MA0002.2 Runx1 MA0002.2 BBYTGTGGTTT Runx1 8.42e-08 8.09e-11 2880 12.5 8400 11 1.14 LR_open
435 49 MA1123.2 TWIST1 MA1123.2 NNDCCAGATGTBN TWIST1 9.32e-08 8.93e-11 22100 96 72900 95.1 1.01 LR_open
436 90 MA0770.1 HSF2 MA0770.1 TTCTAGAAYRTTC HSF2 1.13e-07 1.08e-10 6730 29.2 20700 27 1.08 LR_open
437 12 MA0656.1 JDP2 MA0656.1 GATGACGTCAYC JDP2 4.43e-07 4.22e-10 2100 9.09 5990 7.82 1.16 LR_open
438 58 MA0071.1 RORA MA0071.1 AWMWAGGTCA RORA 5.08e-07 4.83e-10 5910 25.6 18100 23.6 1.08 LR_open
439 42 MA1508.1 IKZF1 MA1508.1 VVAACAGGAARN IKZF1 7.16e-07 6.8e-10 22000 95.4 72400 94.4 1.01 LR_open
440 85 MA0732.1 (EGR3) STREME-7 7-CACCCACACAC CACCCACACAC EGR3 8.82e-07 8.36e-10 268 1.16 563 0.73 1.59 LR_open
441 65 MA1968.1 TFCP2 MA1968.1 AAACCGGTTY TFCP2 1.3e-06 1.23e-09 16000 69.4 51600 67.3 1.03 LR_open
442 91 MA1572.1 TGIF2LY MA1572.1 TGACAGCTGTCA TGIF2LY 1.44e-06 1.35e-09 18400 79.7 59700 77.9 1.02 LR_open
443 38 MA1525.2 NFATC4 MA1525.2 AAYGGAAAMW NFATC4 2.19e-06 2.07e-09 1880 8.15 5360 6.99 1.17 LR_open
444 20 MA1958.1 HOXD12::ELK1 MA1958.1 DRVCGGAAGTCGTAAAD HOXD12::ELK1 8.81e-06 8.27e-09 988 4.29 2660 3.48 1.23 LR_open
445 12 MA1951.1 FOS MA1951.1 BGATGACGTCATCR FOS 8.97e-06 8.4e-09 4980 21.6 15300 19.9 1.09 LR_open
446 58 MA0141.3 ESRRB MA0141.3 TCAAGGTCAWW ESRRB 1.16e-05 1.08e-08 6540 28.4 20300 26.5 1.07 LR_open
447 55 MA0831.3 TFE3 MA0831.3 GTCACGTGAC TFE3 1.94e-05 1.81e-08 4220 18.3 12800 16.8 1.09 LR_open
448 8 MA0507.2 POU2F2 MA0507.2 AWTATGCAAATKAG POU2F2 4.59e-05 4.27e-08 274 1.19 612 0.8 1.49 LR_open
449 90 MA0486.2 HSF1 MA0486.2 TTCTAGAAYRTTC HSF1 6.3e-05 5.85e-08 3310 14.4 9970 13 1.1 LR_open
450 55 MA0828.2 SREBF2 MA0828.2 WWATCACGTGATWW SREBF2 8.43e-05 7.81e-08 1560 6.76 4460 5.81 1.16 LR_open
451 54 MA0688.1 TBX2 MA0688.1 DAGGTGTGAAA TBX2 9.18e-05 8.49e-08 22300 96.6 73500 95.9 1.01 LR_open
452 54 MA0803.1 TBX15 MA0803.1 AGGTGTGA TBX15 0.00011 1.01e-07 2540 11 7520 9.82 1.12 LR_open
453 49 MA1638.1 HAND2 MA1638.1 NVCAGATGNN HAND2 0.000121 1.11e-07 2520 10.9 7490 9.77 1.12 LR_open
454 58 MA0643.1 Esrrg MA0643.1 TCAAGGTCAH Esrrg 0.000125 1.15e-07 8370 36.3 26400 34.5 1.05 LR_open
455 71 MA0511.2 RUNX2 MA0511.2 WAACCGCAA RUNX2 0.000168 1.54e-07 244 1.06 542 0.71 1.5 LR_open
456 49 MA0818.2 BHLHE22 MA0818.2 AMCATATGKY BHLHE22 0.000277 2.53e-07 654 2.84 1730 2.25 1.26 LR_open
457 81 MA1596.1 (ZNF460) MEME-4 RGGAGGCBGAGGHKG RGGAGGCBGAGGHKG ZNF460 0.00031 2.83e-07 196 0.85 418 0.55 1.56 LR_open
458 42 MA1954.1 FOXO1::ELK1 MA1954.1 RWMAACAGGAAGTD FOXO1::ELK1 0.000317 2.88e-07 13100 57 42200 55.1 1.03 LR_open
459 54 MA0805.1 TBX1 MA0805.1 AGGTGTGA TBX1 0.000495 4.5e-07 1350 5.86 3860 5.04 1.16 LR_open
460 54 MA0807.1 TBX5 MA0807.1 AGGTGTKA TBX5 0.00132 1.19e-06 3760 16.3 11500 15 1.08 LR_open
461 86 MA1937.1 ERF::HOXB13 MA1937.1 VSCGGAARYNRTWAAN ERF::HOXB13 0.00148 1.34e-06 8280 35.9 26200 34.2 1.05 LR_open
462 91 MA0797.1 TGIF2 MA0797.1 TGACAGSTGTCA TGIF2 0.0017 1.54e-06 6690 29 21000 27.5 1.06 LR_open
463 12 MA0605.2 ATF3 MA0605.2 RRTGACGTCAYY ATF3 0.0023 2.07e-06 670 2.91 1810 2.36 1.23 LR_open
464 81 MA1587.1 ZNF135 MA1587.1 CCTCGACCTCCYRR ZNF135 0.00315 2.83e-06 928 4.02 2600 3.39 1.19 LR_open
465 54 MA0801.1 MGA MA0801.1 AGGTGTGA MGA 0.0036 3.23e-06 1890 8.19 5600 7.3 1.12 LR_open
466 82 MA0691.1 TFAP4 MA0691.1 AWCAGCTGWT TFAP4 0.00585 5.23e-06 2230 9.67 6690 8.73 1.11 LR_open
467 58 MA0592.3 ESRRA MA0592.3 NBTCAAGGTCAHN ESRRA 0.00677 6.04e-06 8130 35.3 25900 33.7 1.05 LR_open
468 55 MA0692.1 TFEB MA0692.1 RYCACGTGAC TFEB 0.00807 7.19e-06 4500 19.5 14000 18.3 1.07 LR_open
469 92 MA1983.1 ZNF582 MA1983.1 TCTGTTACTTGCAGCCAAAWG ZNF582 0.00898 7.98e-06 4190 18.2 13000 16.9 1.07 LR_open
470 33 MA0870.1 Sox1 MA0870.1 AACAATANCATTGTT Sox1 0.0109 9.66e-06 662 2.87 1820 2.37 1.21 LR_open
471 53 MA0775.1 MEIS3 MA0775.1 DTGACAGS MEIS3 0.012 1.06e-05 22500 97.6 74400 97.1 1.01 LR_open
472 91 MA0667.1 MYF6 MA0667.1 AACARCTGTT MYF6 0.0136 1.2e-05 7640 33.1 24300 31.7 1.05 LR_open
473 42 MA1579.1 ZBTB26 MA1579.1 NNCTCCAGAAANNNN ZBTB26 0.0163 1.44e-05 1000 4.35 2860 3.74 1.16 LR_open
474 49 MA0623.2 NEUROG1 MA0623.2 RACATATGTY NEUROG1 0.023 2.02e-05 601 2.61 1640 2.15 1.22 LR_open
475 31 MA0653.1 IRF9 MA0653.1 AACGAAACCGAAACT IRF9 0.0293 2.57e-05 86 0.37 164 0.21 1.75 LR_open
476 54 MA0806.1 TBX4 MA0806.1 AGGTGTGA TBX4 0.0307 2.68e-05 2520 10.9 7680 10 1.09 LR_open
477 93 MA0130.1 ZNF354C MA0130.1 MTCCAC ZNF354C 0.0356 3.11e-05 1010 4.39 2920 3.81 1.15 LR_open 
ER_rat <- 1.25
mrc_type <- "LR_open"
LR_open_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

LR_open_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*6), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./6,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

LR_close data

LR_close_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_close_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
LR_close_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_close_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
LR_close_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_close_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
LR_close_sea_all <- rbind(LR_close_sea_disc, LR_close_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)
LR_close_combo <- LR_close_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., LR_close_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="LR_close")

LR_close_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")
Enriched motifs 200 bp in EAR open v NR
RANK CLUSTER SIM_MOTIF ALT_ID ID CONSENSUS.x motif_name EVALUE.y QVALUE TP TP. FP FP. ENR_RATIO mrc_type
1 1 MA0774.1 (MEIS2) STREME-1 1-DGCTGTCA DGCTGTCA MEIS2 2.35e-143 1.55e-143 8140 48.6 29000 37.8 1.29 LR_close
2 1 MA0774.1 MEIS2 MA0774.1 TTGACAGS MEIS2 3.53e-106 1.16e-106 6100 36.4 21200 27.7 1.32 LR_close
3 1 MA0774.1 (MEIS2) STREME-3 3-CTGTCWG CTGTCWG MEIS2 2.75e-79 6.03e-80 10800 64.4 43200 56.4 1.14 LR_close
4 2 MA0672.1 (NKX2-3) STREME-2 2-CCACTTRA CCACTTRA NKX2-3 7.25e-77 1.19e-77 5860 35 21200 27.6 1.27 LR_close
5 2 MA0672.1 NKX2-3 MA0672.1 VCCACTTRAV NKX2-3 3.82e-63 5.03e-64 6830 40.8 25900 33.8 1.21 LR_close
6 1 MA0775.1 MEIS3 MA0775.1 DTGACAGS MEIS3 1.42e-62 1.56e-63 2080 12.4 6200 8.08 1.53 LR_close
7 1 MA0498.2 MEIS1 MA0498.2 HTGACAD MEIS1 1.37e-57 1.29e-58 7070 42.2 27200 35.4 1.19 LR_close
8 3 MA0739.1 (Hic1) STREME-5 5-ATGCCA ATGCCA Hic1 6.58e-54 5.41e-55 12500 74.8 52600 68.6 1.09 LR_close
9 2 MA2003.1 NKX2-4 MA2003.1 CCACTTSAVV NKX2-4 1.07e-47 7.84e-49 2700 16.1 9020 11.8 1.37 LR_close
10 4 MA0140.2 (GATA1::TAL1) STREME-6 6-WGATAA WGATAA GATA1::TAL1 1.41e-46 9.31e-48 10700 64.1 44400 57.9 1.11 LR_close
11 2 MA0673.1 NKX2-8 MA0673.1 VCACTTSAV NKX2-8 1.65e-45 9.9e-47 6820 40.7 26600 34.7 1.17 LR_close
12 5 MA1655.1 (ZNF341) STREME-11 11-ACAGCCA 11-ACAGCCA ZNF341 2.22e-38 1.22e-39 12200 73 51900 67.7 1.08 LR_close
13 2 MA0124.2 Nkx3-1 MA0124.2 RCCACTTAA Nkx3-1 2.88e-34 1.46e-35 4780 28.5 18200 23.8 1.2 LR_close
14 6 MA1972.1 (ZFP14) STREME-12 12-CAGGGCCT 12-CAGGGCCT ZFP14 1.36e-33 6.39e-35 8330 49.7 34000 44.4 1.12 LR_close
15 7 8-CTGCACA STREME-8 8-CTGCACA CTGCACA CTGCACA 1.95e-33 8.55e-35 14700 87.5 64200 83.7 1.05 LR_close
16 8 MA0723.2 VAX2 MA0723.2 BYAATTAV VAX2 1.1e-31 4.51e-33 16000 95.4 71200 92.9 1.03 LR_close
17 9 MA0161.2 NFIC MA0161.2 NNCTTGGCANN NFIC 2.26e-31 8.75e-33 9160 54.7 37900 49.5 1.1 LR_close
18 10 MA0084.1 SRY MA0084.1 NWWAACAAT SRY 8.13e-31 2.97e-32 15500 92.4 68500 89.4 1.03 LR_close
19 11 MA0092.1 Hand1::Tcf3 MA0092.1 BRTCTGGMWT Hand1::Tcf3 2.48e-30 8.58e-32 15400 91.7 67900 88.6 1.03 LR_close
20 1 MA0797.1 TGIF2 MA0797.1 TGACAGSTGTCA TGIF2 8.5e-30 2.8e-31 3760 22.5 14100 18.4 1.22 LR_close
21 1 MA0739.1 Hic1 MA0739.1 RTGCCAACY Hic1 1.73e-29 5.39e-31 7070 42.2 28600 37.3 1.13 LR_close
22 8 MA0882.1 DLX6 MA0882.1 VYAATTAN DLX6 1.8e-29 5.39e-31 15800 94.2 70200 91.6 1.03 LR_close
23 8 MA0674.1 NKX6-1 MA0674.1 NTMATTAA NKX6-1 2.11e-29 6.05e-31 15500 92.5 68700 89.6 1.03 LR_close
24 12 MA0808.1 TEAD3 MA0808.1 RCATTCCW TEAD3 1.03e-27 2.84e-29 10200 60.8 42900 56 1.09 LR_close
25 13 7-AGCACT STREME-7 7-AGCACT AGCACT AGCACT 1.59e-26 4.17e-28 15400 91.9 68300 89.1 1.03 LR_close
26 10 MA1152.1 SOX15 MA1152.1 CYWTTGTTHW SOX15 1.41e-25 3.57e-27 15800 94.6 70700 92.3 1.03 LR_close
27 8 MA0722.1 VAX1 MA0722.1 YTAATTAH VAX1 2.16e-25 5.27e-27 15800 94.1 70200 91.6 1.03 LR_close
28 8 MA0675.1 NKX6-2 MA0675.1 NYMATTAA NKX6-2 2.64e-25 6.2e-27 15800 94 70200 91.6 1.03 LR_close
29 8 MA0879.2 DLX1 MA0879.2 VYAATTAN DLX1 3.64e-25 8.25e-27 15700 93.6 69800 91 1.03 LR_close
30 9 MA0671.1 NFIX MA0671.1 NNTGCCAAN NFIX 1.39e-24 3.06e-26 11200 66.8 47800 62.3 1.07 LR_close
31 8 MA0630.1 SHOX MA0630.1 HTAATTRR SHOX 1.46e-24 3.09e-26 15200 90.8 67400 88 1.03 LR_close
32 8 MA0125.1 Nobox MA0125.1 TAATTRSY Nobox 1.63e-24 3.27e-26 14500 86.6 63800 83.3 1.04 LR_close
33 8 MA0881.1 Dlx4 MA0881.1 VYAATTAN Dlx4 1.64e-24 3.27e-26 15800 94.4 70600 92.1 1.03 LR_close
34 14 10-WGKGCMCW STREME-10 10-WGKGCMCW 10-WGKGCMCW WGKGCMCW 2.27e-24 4.39e-26 8290 49.5 34400 44.9 1.1 LR_close
35 15 MA0792.1 POU5F1B MA0792.1 TATGCWAAT POU5F1B 3.53e-24 6.63e-26 15000 89.3 66200 86.3 1.04 LR_close
36 8 MA0718.1 RAX MA0718.1 RYYAATTARH RAX 6.76e-24 1.24e-25 14500 86.3 63600 83 1.04 LR_close
37 16 MA0626.1 Npas2 MA0626.1 NSCACGTGTN Npas2 1.65e-23 2.86e-25 8520 50.9 35500 46.4 1.1 LR_close
38 8 MA0720.1 Shox2 MA0720.1 YYAATTAR Shox2 1.65e-23 2.86e-25 15000 89.3 66200 86.4 1.03 LR_close
39 8 MA0726.1 VSX2 MA0726.1 CTAATTAN VSX2 3.18e-23 5.37e-25 15100 90.1 66800 87.2 1.03 LR_close
40 17 MA0035.4 GATA1 MA0035.4 NHCTAATCTDH GATA1 6.01e-23 9.88e-25 15300 91.2 67800 88.4 1.03 LR_close
41 18 CTGCCTGCCTG MEME-5 CTGCCTGCCTG CTGCCTGCCTG CTGCCTGCCTG 1.66e-22 2.67e-24 10700 63.9 45600 59.6 1.07 LR_close
42 12 MA0809.2 TEAD4 MA0809.2 NNACATTCCARN TEAD4 3.36e-22 5.26e-24 6680 39.9 27300 35.6 1.12 LR_close
43 8 MA0716.1 PRRX1 MA0716.1 YYAATTAR PRRX1 1.1e-21 1.68e-23 15200 90.5 67300 87.8 1.03 LR_close
44 8 MA1505.1 HOXC8 MA1505.1 KTAATTAM HOXC8 1.66e-21 2.49e-23 15300 91.6 68200 89 1.03 LR_close
45 8 MA0725.1 VSX1 MA0725.1 YTAATTAN VSX1 2.11e-21 3.09e-23 15900 95 71300 93 1.02 LR_close
46 12 MA0090.3 TEAD1 MA0090.3 NNACATTCCAGSN TEAD1 1.52e-20 2.17e-22 9180 54.8 38800 50.6 1.08 LR_close
47 8 MA0027.2 EN1 MA0027.2 SYAATTAV EN1 2.64e-20 3.7e-22 14700 87.8 65100 84.9 1.03 LR_close
48 19 MA0148.4 FOXA1 MA0148.4 WWGTAAACATNN FOXA1 3.21e-20 4.32e-22 15300 91.2 67900 88.6 1.03 LR_close
49 8 MA1476.2 Dlx5 MA1476.2 NDGCAATTAGNN Dlx5 3.21e-20 4.32e-22 14500 86.8 64300 83.9 1.04 LR_close
50 10 MA0077.1 SOX9 MA0077.1 CYATTGTTY SOX9 7.33e-20 9.65e-22 16300 97.3 73400 95.8 1.02 LR_close
51 4 MA1104.2 GATA6 MA1104.2 HWWTCTTATCTNH GATA6 2.71e-19 3.5e-21 15300 91.3 68100 88.8 1.03 LR_close
52 19 MA0481.3 FOXP1 MA0481.3 NDGTAAACANH FOXP1 7.26e-19 9.19e-21 15400 92 68700 89.6 1.03 LR_close
53 16 MA0633.2 Twist2 MA0633.2 NVCAGCTGBN Twist2 9.42e-19 1.17e-20 2800 16.7 10600 13.8 1.21 LR_close
54 8 MA0634.1 ALX3 MA0634.1 YYYAATTANV ALX3 1.19e-18 1.45e-20 14800 88.5 65800 85.8 1.03 LR_close
55 8 MA0635.1 BARHL2 MA0635.1 VHTAAAYGRT BARHL2 1.32e-18 1.58e-20 14900 88.9 66100 86.2 1.03 LR_close
56 8 MA0885.2 Dlx2 MA0885.2 NDGCAATTAGNN Dlx2 2.21e-18 2.6e-20 14000 83.6 61700 80.6 1.04 LR_close
57 15 MA1115.1 POU5F1 MA1115.1 WHATGCAAATN POU5F1 2.62e-18 3.03e-20 15200 91 67900 88.6 1.03 LR_close
58 16 MA1635.1 BHLHE22 MA1635.1 NVCAGCTGBN BHLHE22 3.63e-18 4.12e-20 2830 16.9 10700 14 1.2 LR_close
59 9 MA0670.1 NFIA MA0670.1 NDTGCCAAND NFIA 3.98e-18 4.42e-20 1670 9.98 5930 7.74 1.29 LR_close
60 8 MA0880.1 Dlx3 MA0880.1 NYAATTAN Dlx3 4.03e-18 4.42e-20 14800 88.3 65600 85.6 1.03 LR_close
61 4 MA0766.2 GATA5 MA0766.2 SWGATAASRN GATA5 7.07e-18 7.62e-20 4260 25.4 16900 22.1 1.15 LR_close
62 16 MA1997.1 Olig2 MA1997.1 NVCAGCTGBN Olig2 7.21e-18 7.65e-20 2810 16.8 10700 13.9 1.2 LR_close
63 16 MA1993.1 Neurod2 MA1993.1 VVCAGCTGBB Neurod2 1.22e-17 1.28e-19 2770 16.6 10500 13.8 1.2 LR_close
64 19 MA0845.1 FOXB1 MA0845.1 WATGTAAATAT FOXB1 3.08e-17 3.17e-19 13900 82.7 61100 79.7 1.04 LR_close
65 8 MA1608.1 Isl1 MA1608.1 NNCCATTAGNN Isl1 4.67e-17 4.73e-19 15500 92.8 69500 90.6 1.02 LR_close
66 20 MA0650.3 Hoxa13 MA0650.3 NNCCAATAAAAN Hoxa13 6.2e-17 6.18e-19 14800 88.5 65800 85.9 1.03 LR_close
67 2 MA1994.1 Nkx2-1 MA1994.1 NVCACTTGARHNN Nkx2-1 7.81e-17 7.67e-19 1360 8.14 4740 6.18 1.32 LR_close
68 8 MA0721.1 UNCX MA0721.1 YYAATTAV UNCX 8.53e-17 8.26e-19 15700 94 70500 92 1.02 LR_close
69 19 MA0047.3 FOXA2 MA0047.3 RWGTAAACANN FOXA2 1.11e-16 1.06e-18 15100 89.9 67000 87.4 1.03 LR_close
70 19 MA1606.1 Foxf1 MA1606.1 DWRTAAACANN Foxf1 1.4e-16 1.32e-18 15100 90 67100 87.5 1.03 LR_close
71 21 MA0667.1 MYF6 MA0667.1 AACARCTGTT MYF6 1.93e-16 1.79e-18 8310 49.6 35100 45.8 1.08 LR_close
72 8 MA0892.1 GSX1 MA0892.1 NCYMATTAVN GSX1 5.56e-16 5.08e-18 16200 96.8 73000 95.3 1.02 LR_close
73 20 MA0465.2 CDX2 MA0465.2 NDGCAATAAAWN CDX2 5.77e-16 5.2e-18 15000 89.4 66600 87 1.03 LR_close
74 4 MA0036.3 GATA2 MA0036.3 NBCTTATCTNH GATA2 6.79e-16 6.04e-18 5350 32 21900 28.5 1.12 LR_close
75 8 MA0704.1 Lhx4 MA0704.1 YTAATTAR Lhx4 1e-15 8.8e-18 13700 82 60600 79.1 1.04 LR_close
76 8 MA0903.1 HOXB3 MA0903.1 NNYMATTARN HOXB3 1.13e-15 9.8e-18 15800 94.1 70700 92.2 1.02 LR_close
77 9 MA1643.1 NFIB MA1643.1 NNCCTGGCAYNGTGCCAAGNN NFIB 4.8e-15 4.1e-17 3010 18 11700 15.3 1.18 LR_close
78 8 MA0786.1 POU3F1 MA0786.1 WTATGCWAATKW POU3F1 8.03e-15 6.78e-17 13700 81.9 60500 79 1.04 LR_close
79 4 MA1970.1 TRPS1 MA1970.1 NHTCTTATCTNH TRPS1 1.09e-14 9.05e-17 14400 85.9 63800 83.3 1.03 LR_close
80 19 MA1683.1 FOXA3 MA1683.1 DWGTAAACANN FOXA3 1.17e-14 9.64e-17 15600 93 69700 91 1.02 LR_close
81 10 MA0143.4 SOX2 MA0143.4 DNACAATGGNN SOX2 1.87e-14 1.52e-16 16100 95.9 72300 94.3 1.02 LR_close
82 1 MA0119.1 NFIC::TLX1 MA0119.1 TGGCASSRWGCCAA NFIC::TLX1 2e-14 1.61e-16 1400 8.33 4960 6.48 1.29 LR_close
83 22 MA0018.4 (CREB1) STREME-4 4-GTGATGACA GTGATGACA CREB1 2.17e-14 1.72e-16 380 2.27 1030 1.35 1.69 LR_close
84 1 MA0783.1 PKNOX2 MA0783.1 TGACAGGTGTCA PKNOX2 4.23e-14 3.32e-16 587 3.5 1790 2.34 1.5 LR_close
85 23 MA0769.2 TCF7 MA0769.2 NNCTTTGAWVT TCF7 5.05e-14 3.91e-16 15800 94.3 70900 92.5 1.02 LR_close
86 12 MA1121.1 TEAD2 MA1121.1 NYACATTCCWNNS TEAD2 5.4e-14 4.13e-16 10100 60.2 43500 56.7 1.06 LR_close
87 8 MA0710.1 NOTO MA0710.1 NYTAATTAVN NOTO 6.31e-14 4.77e-16 13700 81.9 60600 79.1 1.04 LR_close
88 8 MA0899.1 HOXA10 MA0899.1 DGYMATAAAAH HOXA10 6.57e-14 4.87e-16 14600 87.1 64900 84.6 1.03 LR_close
89 19 MA1103.2 FOXK2 MA1103.2 DDGTAAACANN FOXK2 6.59e-14 4.87e-16 15900 94.7 71300 93 1.02 LR_close
90 21 MA0816.1 Ascl2 MA0816.1 ARCAGCTGCY Ascl2 8.08e-14 5.91e-16 6000 35.8 24900 32.5 1.1 LR_close
91 9 MA1528.1 NFIX MA1528.1 STTGGCRNNGTGCCARB NFIX 1.04e-13 7.43e-16 2500 14.9 9590 12.5 1.19 LR_close
92 8 MA0717.1 RAX2 MA0717.1 YYAATTAV RAX2 1.05e-13 7.43e-16 16000 95.7 72200 94.2 1.02 LR_close
93 16 MA1472.2 Bhlha15 MA1472.2 NVACAGCTGTBN Bhlha15 1.05e-13 7.43e-16 7560 45.2 32000 41.7 1.08 LR_close
94 8 MA0662.1 MIXL1 MA0662.1 NBYAATTAVN MIXL1 1.28e-13 8.99e-16 15800 94.6 71200 92.9 1.02 LR_close
95 24 MA0052.4 MEF2A MA0052.4 DDCTAAAAATAGMHH MEF2A 1.82e-13 1.26e-15 13600 81.1 60000 78.3 1.04 LR_close
96 19 MA0846.1 FOXC2 MA0846.1 WAWGTAAACAWW FOXC2 2.96e-13 2.03e-15 14400 85.9 63900 83.4 1.03 LR_close
97 1 MA0796.1 TGIF1 MA0796.1 TGACAGCTGTCA TGIF1 3.08e-13 2.09e-15 643 3.84 2030 2.64 1.45 LR_close
98 8 MA0068.2 PAX4 MA0068.2 CTAATTAG PAX4 3.22e-13 2.16e-15 14900 89 66500 86.8 1.03 LR_close
99 19 MA0033.2 FOXL1 MA0033.2 RTAAACA FOXL1 3.39e-13 2.25e-15 14400 86.1 64100 83.6 1.03 LR_close
100 8 MA0708.2 MSX2 MA0708.2 SCAATTAV MSX2 4.86e-13 3.2e-15 13400 79.8 59000 77 1.04 LR_close
101 25 MA0041.2 FOXD3 MA0041.2 WAWGHAAATAAACARY FOXD3 1.02e-12 6.62e-15 14100 84 62400 81.4 1.03 LR_close
102 8 MA0876.1 BSX MA0876.1 SYVATTAV BSX 1.03e-12 6.62e-15 14100 84.2 62600 81.6 1.03 LR_close
103 26 MA0738.1 HIC2 MA0738.1 RTGCCCRSB HIC2 2.89e-12 1.85e-14 7540 45 32000 41.7 1.08 LR_close
104 16 MA1641.1 MYF5 MA1641.1 NVACAGCTGTBN MYF5 3.34e-12 2.12e-14 5420 32.4 22500 29.3 1.1 LR_close
105 8 MA0644.2 ESX1 MA0644.2 YYAATTAN ESX1 5.67e-12 3.55e-14 13300 79.3 58700 76.6 1.04 LR_close
106 8 MA1497.1 HOXA6 MA1497.1 BGYMATTANN HOXA6 5.74e-12 3.56e-14 14900 88.9 66500 86.8 1.02 LR_close
107 1 MA1571.1 TGIF2LX MA1571.1 TGACAGCTGTCA TGIF2LX 8.56e-12 5.27e-14 2200 13.1 8440 11 1.19 LR_close
108 2 MA0063.2 NKX2-5 MA0063.2 NNCACTCAANN NKX2-5 9.62e-12 5.86e-14 1260 7.5 4510 5.89 1.27 LR_close
109 8 MA0709.1 Msx3 MA0709.1 SCAATTAN Msx3 1.22e-11 7.34e-14 13600 81.3 60300 78.7 1.03 LR_close
110 19 MA0157.3 Foxo3 MA0157.3 NDGTAAACARNN Foxo3 1.54e-11 9.2e-14 16200 96.9 73300 95.7 1.01 LR_close
111 8 MA0648.1 GSC MA0648.1 VYTAATCCSY GSC 2.27e-11 1.34e-13 15400 92 69100 90.1 1.02 LR_close
112 22 MA0018.4 CREB1 MA0018.4 NNRTGATGTCAYN CREB1 2.51e-11 1.47e-13 14000 83.8 62300 81.3 1.03 LR_close
113 27 MA0714.1 PITX3 MA0714.1 NYTAATCCC PITX3 4.59e-11 2.67e-13 16400 97.9 74200 96.8 1.01 LR_close
114 28 MA0495.3 MAFF MA0495.3 DWGTCAGCATTTTWHN MAFF 4.95e-11 2.85e-13 14900 88.8 66500 86.8 1.02 LR_close
115 21 MA0665.1 MSC MA0665.1 AACAGCTGTT MSC 5.14e-11 2.94e-13 7620 45.5 32500 42.4 1.07 LR_close
116 17 MA0712.2 OTX2 MA0712.2 NDRGGATTARNN OTX2 5.25e-11 2.98e-13 15500 92.3 69400 90.5 1.02 LR_close
117 19 MA0850.1 FOXP3 MA0850.1 RTAAACA FOXP3 5.57e-11 3.13e-13 14900 89 66600 87 1.02 LR_close
118 8 MA0887.1 EVX1 MA0887.1 VVTAATTABS EVX1 5.66e-11 3.16e-13 16300 97.4 73700 96.2 1.01 LR_close
119 2 MA0122.3 Nkx3-2 MA0122.3 WWAAMCACTTAAN Nkx3-2 5.72e-11 3.16e-13 9320 55.6 40200 52.5 1.06 LR_close
120 8 MA0666.2 MSX1 MA0666.2 SCAATTAR MSX1 5.97e-11 3.28e-13 11800 70.6 51900 67.7 1.04 LR_close
121 8 MA0699.1 LBX2 MA0699.1 NCYAATTARN LBX2 6.86e-11 3.73e-13 15300 91.1 68400 89.2 1.02 LR_close
122 19 MA1607.1 Foxl2 MA1607.1 DDWATGTAAACANN Foxl2 2.43e-10 1.31e-12 14400 86.2 64400 84 1.03 LR_close
123 15 MA0789.1 POU3F4 MA0789.1 TATGCWAAT POU3F4 2.71e-10 1.45e-12 11900 71 52300 68.2 1.04 LR_close
124 29 MA0025.2 NFIL3 MA0025.2 NRTTATGYAATNN NFIL3 3.79e-10 2.01e-12 14500 86.6 64700 84.5 1.03 LR_close
125 30 MA1615.1 Plagl1 MA1615.1 NNCTGGGGCCABN Plagl1 4.71e-10 2.48e-12 15100 89.9 67400 88 1.02 LR_close
126 4 MA0140.2 GATA1::TAL1 MA0140.2 MTTATCWSNNNNNHVCAG GATA1::TAL1 1.37e-09 7.13e-12 5300 31.7 22200 28.9 1.09 LR_close
127 25 MA1978.1 ZNF354A MA1978.1 HWAADWATAAATGRAYWAWTT ZNF354A 1.5e-09 7.75e-12 14100 84.3 62900 82 1.03 LR_close
128 8 MA0893.2 GSX2 MA0893.2 SYMATTAR GSX2 1.71e-09 8.81e-12 15800 94.1 71000 92.6 1.02 LR_close
129 31 MA1566.2 TBX3 MA1566.2 RAGGTGTGAAV TBX3 1.73e-09 8.82e-12 6030 36 25400 33.2 1.08 LR_close
130 21 MA0691.1 TFAP4 MA0691.1 AWCAGCTGWT TFAP4 1.97e-09 9.95e-12 3360 20.1 13600 17.8 1.13 LR_close
131 9 MA1527.1 NFIC MA1527.1 NTTGGCDNNRTGCCARN NFIC 2.21e-09 1.11e-11 1210 7.21 4420 5.77 1.25 LR_close
132 19 MA0032.2 FOXC1 MA0032.2 WAWGTAAAYAW FOXC1 2.64e-09 1.32e-11 13800 82.4 61400 80.1 1.03 LR_close
133 8 MA1498.2 HOXA7 MA1498.2 SYMATTAV HOXA7 2.86e-09 1.41e-11 16500 98.5 74800 97.7 1.01 LR_close
134 8 MA0706.1 MEOX2 MA0706.1 DSTAATTAWN MEOX2 4.36e-09 2.14e-11 14500 86.6 64800 84.6 1.02 LR_close
135 8 MA0642.2 EN2 MA0642.2 VSYAATTA EN2 5.67e-09 2.76e-11 13300 79.5 59100 77.1 1.03 LR_close
136 10 MA0514.2 Sox3 MA0514.2 DNACAATGGNN Sox3 6.01e-09 2.91e-11 15500 92.8 69900 91.2 1.02 LR_close
137 8 MA0700.2 LHX2 MA0700.2 DDCCAATTADN LHX2 6.28e-09 3.02e-11 12400 74.3 55000 71.7 1.04 LR_close
138 8 MA0890.1 GBX2 MA0890.1 RSYAATTARN GBX2 8.3e-09 3.96e-11 12800 76.6 56800 74.1 1.03 LR_close
139 29 MA0102.4 CEBPA MA0102.4 NDATTGCACAATHN CEBPA 1.96e-08 9.28e-11 14400 86.2 64500 84.2 1.02 LR_close
140 20 MA1644.1 NFYC MA1644.1 RDCCAATCASN NFYC 2.01e-08 9.43e-11 11500 68.7 50600 66.1 1.04 LR_close
141 47 MA1102.2 CTCFL MA1102.2 NSCAGGGGGCGS CTCFL 3.39e-08 1.58e-10 14300 85.4 63900 83.4 1.02 LR_close
142 4 MA0482.2 GATA4 MA0482.2 NNCCTTATCTNH GATA4 3.96e-08 1.84e-10 12300 73.6 54500 71.1 1.03 LR_close
143 26 MA0597.2 THAP1 MA0597.2 VSGCAGGGCASV THAP1 5.27e-08 2.43e-10 15800 94.3 71300 93 1.01 LR_close
144 8 MA1500.1 HOXB6 MA1500.1 BTAATKRC HOXB6 7.16e-08 3.27e-10 12700 76.1 56500 73.7 1.03 LR_close
145 21 MA0669.1 NEUROG2 MA0669.1 RACATATGTC NEUROG2 7.49e-08 3.4e-10 6030 36 25600 33.4 1.08 LR_close
146 8 MA0888.1 EVX2 MA0888.1 VVTAATTAVB EVX2 9.89e-08 4.46e-10 16300 97.6 74100 96.6 1.01 LR_close
147 32 MA1639.1 MEIS1 MA1639.1 NHCATMAATCAHN MEIS1 1.33e-07 5.94e-10 14500 86.6 64900 84.7 1.02 LR_close
148 10 MA1120.1 SOX13 MA1120.1 DVACAATGGNN SOX13 1.34e-07 5.94e-10 15600 93.2 70400 91.8 1.02 LR_close
149 23 MA0768.2 Lef1 MA0768.2 NNBCCTTTGATSTN Lef1 1.49e-07 6.58e-10 16400 98.1 74600 97.3 1.01 LR_close
150 15 MA0627.2 POU2F3 MA0627.2 NWTATGCAAATNH POU2F3 1.63e-07 7.15e-10 12700 75.6 56200 73.3 1.03 LR_close
151 16 MA0521.2 Tcf12 MA0521.2 NNACAGCTGTNN Tcf12 1.66e-07 7.24e-10 4200 25.1 17500 22.8 1.1 LR_close
152 8 MA1471.1 BARX2 MA1471.1 NWWAAYMATTAN BARX2 2.78e-07 1.2e-09 13400 80.2 59800 78 1.03 LR_close
153 19 MA0848.1 FOXO4 MA0848.1 GTAAACA FOXO4 3.84e-07 1.65e-09 14400 85.8 64300 83.9 1.02 LR_close
154 31 MA0688.1 TBX2 MA0688.1 DAGGTGTGAAA TBX2 5.03e-07 2.15e-09 9790 58.5 42800 55.9 1.05 LR_close
155 2 MA0914.1 ISL2 MA0914.1 GCAMTTAR ISL2 1.26e-06 5.33e-09 15900 94.7 71600 93.4 1.01 LR_close
156 31 MA0803.1 TBX15 MA0803.1 AGGTGTGA TBX15 2.45e-06 1.03e-08 6060 36.2 25900 33.8 1.07 LR_close
157 26 MA1728.1 ZNF549 MA1728.1 NNTGCTGCCCWR ZNF549 2.98e-06 1.25e-08 15400 91.9 69400 90.5 1.02 LR_close
158 8 MA0889.1 GBX1 MA0889.1 VCYAATTASY GBX1 5.33e-06 2.22e-08 11600 69 51100 66.7 1.03 LR_close
159 20 MA1963.1 SATB1 MA1963.1 WWDCTAATAAHWW SATB1 7.94e-06 3.29e-08 11800 70.2 52100 68 1.03 LR_close
160 8 MA1549.1 POU6F1 MA1549.1 RTAATGAGVN POU6F1 9.6e-06 3.95e-08 14600 87.1 65500 85.4 1.02 LR_close
161 1 MA1572.1 TGIF2LY MA1572.1 TGACAGCTGTCA TGIF2LY 1.02e-05 4.17e-08 986 5.89 3700 4.82 1.22 LR_close
162 31 MA0802.1 TBR1 MA0802.1 AGGTGTGAAA TBR1 1.16e-05 4.7e-08 3400 20.3 14100 18.4 1.1 LR_close
163 8 MA0875.1 BARX1 MA0875.1 VCMATTAV BARX1 1.5e-05 6.04e-08 13200 79 59000 77 1.03 LR_close
164 8 MA0894.1 HESX1 MA0894.1 GHTAATTRRH HESX1 1.69e-05 6.79e-08 10800 64.7 47800 62.4 1.04 LR_close
165 31 MA0805.1 TBX1 MA0805.1 AGGTGTGA TBX1 1.74e-05 6.88e-08 3940 23.5 16500 21.6 1.09 LR_close
166 33 MA1573.2 (Thap11) STREME-9 9-CTGGGAAATGTAGTY CTGGGAAATGTAGTY Thap11 1.74e-05 6.88e-08 33 0.2 37 0.05 4.09 LR_close
167 8 MA1960.1 MGA::EVX1 MA1960.1 RGGTGWTAATKD MGA::EVX1 1.92e-05 7.57e-08 4760 28.4 20200 26.4 1.08 LR_close
168 34 MA0606.2 Nfat5 MA0606.2 NNATGGAAAAWN Nfat5 2.38e-05 9.33e-08 15700 93.9 71100 92.7 1.01 LR_close
169 8 MA0661.1 MEOX1 MA0661.1 VSTAATTAHC MEOX1 2.61e-05 1.02e-07 13600 81.1 60800 79.3 1.02 LR_close
170 27 MA0719.1 RHOXF1 MA0719.1 NTRATCCN RHOXF1 2.69e-05 1.04e-07 14800 88.4 66500 86.8 1.02 LR_close
171 16 MA0500.2 MYOG MA0500.2 NDRCAGCTGYHN MYOG 2.99e-05 1.15e-07 12500 74.4 55500 72.4 1.03 LR_close
172 23 MA1991.1 Hnf1A MA1991.1 NBCCTTTGATSTBN Hnf1A 4.51e-05 1.73e-07 15900 94.8 71900 93.8 1.01 LR_close
173 11 MA1153.1 Smad4 MA1153.1 TGTCTRGM Smad4 6.81e-05 2.59e-07 2560 15.3 10500 13.7 1.11 LR_close
174 34 MA0624.2 Nfatc1 MA0624.2 NVATGGAAAAWN Nfatc1 9.27e-05 3.51e-07 15200 91 68700 89.7 1.01 LR_close
175 32 MA1113.2 PBX2 MA1113.2 NHCATAAATCAHN PBX2 0.000124 4.66e-07 13600 81.4 61100 79.7 1.02 LR_close
176 35 MA1112.2 NR4A1 MA1112.2 NNAAAGGTCANN NR4A1 0.000149 5.56e-07 14200 84.9 63800 83.3 1.02 LR_close
177 33 MA1573.2 Thap11 MA1573.2 ACTACAABTCCCAG Thap11 0.000161 5.98e-07 49 0.29 84 0.11 2.69 LR_close
178 21 MA0832.1 Tcf21 MA0832.1 RYAACAGCTGTTRN Tcf21 0.000165 6.06e-07 1660 9.89 6620 8.64 1.15 LR_close
179 23 MA0523.1 TCF7L2 MA0523.1 DRASATCAAAGRVA TCF7L2 0.000165 6.06e-07 10800 64.6 47900 62.5 1.03 LR_close
180 15 MA0142.1 Pou5f1::Sox2 MA0142.1 CWTTGTYATGCAAAT Pou5f1::Sox2 0.000166 6.06e-07 12900 77.3 57800 75.4 1.02 LR_close
181 8 MA0654.1 ISX MA0654.1 YYAATTAR ISX 0.000188 6.82e-07 10100 60.4 44700 58.3 1.04 LR_close
182 19 MA0480.2 Foxo1 MA0480.2 NDGTAAACANN Foxo1 0.000202 7.32e-07 16500 98.4 75000 97.8 1.01 LR_close
183 31 MA0690.2 TBX21 MA0690.2 TTTCACACCTT TBX21 0.000274 9.84e-07 5910 35.3 25500 33.3 1.06 LR_close
184 36 MA0130.1 ZNF354C MA0130.1 MTCCAC ZNF354C 0.000367 1.31e-06 14500 86.3 65000 84.8 1.02 LR_close
185 8 MA0601.1 Arid3b MA0601.1 ATATTAATWAN Arid3b 0.000371 1.32e-06 10500 62.6 46400 60.5 1.03 LR_close
186 9 MA0502.2 NFYB MA0502.2 CYCATTGGCCVV NFYB 0.000375 1.33e-06 1070 6.41 4160 5.42 1.18 LR_close
187 31 MA1567.2 Tbx6 MA1567.2 NRGGTGTGAANN Tbx6 0.00049 1.73e-06 4600 27.4 19600 25.6 1.07 LR_close
188 21 MA0698.1 ZBTB18 MA0698.1 NATCCAGATGTKB ZBTB18 0.000493 1.73e-06 4260 25.4 18100 23.7 1.08 LR_close
189 8 MA0132.2 PDX1 MA0132.2 VYAATTAR PDX1 0.000516 1.79e-06 9990 59.6 44100 57.6 1.04 LR_close
190 16 MA0820.1 FIGLA MA0820.1 WMCACCTGKW FIGLA 0.000606 2.1e-06 16000 95.4 72400 94.4 1.01 LR_close
191 16 MA0499.2 MYOD1 MA0499.2 NNGCACCTGTCNB MYOD1 0.000664 2.29e-06 15600 93.2 70600 92.1 1.01 LR_close
192 16 MA1620.1 Ptf1A MA1620.1 NVACACCTGTNN Ptf1A 0.000721 2.47e-06 13200 78.5 58900 76.8 1.02 LR_close
193 9 MA1979.1 ZNF416 MA1979.1 TATCTGGGCAH ZNF416 0.000745 2.54e-06 12900 77.2 57800 75.5 1.02 LR_close
194 37 MA0071.1 RORA MA0071.1 AWMWAGGTCA RORA 0.000895 3.04e-06 2490 14.9 10300 13.5 1.1 LR_close
195 16 MA1108.2 MXI1 MA1108.2 NNCACATGBN MXI1 0.00114 3.84e-06 1910 11.4 7810 10.2 1.12 LR_close
196 8 MA0628.1 POU6F1 MA0628.1 AYTAATTART POU6F1 0.00139 4.66e-06 13400 80.2 60200 78.6 1.02 LR_close
197 38 MA0108.2 TBP MA0108.2 STATAAAWRSVVVBN TBP 0.00141 4.71e-06 14000 83.8 63100 82.3 1.02 LR_close
198 16 MA1619.1 Ptf1A MA1619.1 NNACAGCTGTNN Ptf1A 0.00148 4.93e-06 8400 50.1 36900 48.2 1.04 LR_close
199 8 MA0711.1 OTX1 MA0711.1 HTAATCCS OTX1 0.00218 7.21e-06 12300 73.5 55000 71.8 1.02 LR_close
200 39 MA1515.1 KLF2 MA1515.1 NRCCACRCCCH KLF2 0.00323 1.06e-05 15700 93.5 70900 92.5 1.01 LR_close
201 16 MA1558.1 SNAI1 MA1558.1 DRCAGGTGYD SNAI1 0.00337 1.1e-05 13900 83.2 62600 81.7 1.02 LR_close
202 31 MA0801.1 MGA MA0801.1 AGGTGTGA MGA 0.00363 1.18e-05 5920 35.4 25700 33.6 1.05 LR_close
203 8 MA0904.2 HOXB5 MA0904.2 STAATTAS HOXB5 0.00432 1.4e-05 10500 62.8 46800 61 1.03 LR_close
204 8 MA0891.1 GSC2 MA0891.1 NYTAATCCBH GSC2 0.00449 1.45e-05 16500 98.8 75400 98.3 1 LR_close
205 16 MA0830.2 TCF4 MA0830.2 NNGCACCTGCCNN TCF4 0.00598 1.92e-05 14300 85.3 64300 83.9 1.02 LR_close
206 40 MA1707.1 DMRTA1 MA1707.1 AWTTGWTACAWT DMRTA1 0.0062 1.98e-05 13100 78.4 58900 76.9 1.02 LR_close
207 20 MA0909.3 Hoxd13 MA0909.3 NNCAATAAAW Hoxd13 0.00642 2.04e-05 10300 61.5 45800 59.7 1.03 LR_close
208 39 MA0039.4 KLF4 MA0039.4 NNCCCCACCCHN KLF4 0.0088 2.78e-05 14900 89.2 67500 88.1 1.01 LR_close
209 16 MA1618.1 Ptf1a MA1618.1 NNACAGATGTTNN Ptf1a 0.00903 2.84e-05 4420 26.4 19000 24.8 1.06 LR_close
210 16 MA1559.1 SNAI3 MA1559.1 RRCAGGTGYA SNAI3 0.00948 2.97e-05 10000 59.7 44400 57.9 1.03 LR_close
211 16 MA0623.2 NEUROG1 MA0623.2 RACATATGTY NEUROG1 0.0106 3.31e-05 1140 6.83 4560 5.95 1.15 LR_close
212 16 MA1100.2 ASCL1 MA1100.2 VGCAGCTGCN ASCL1 0.0135 4.19e-05 14000 83.9 63300 82.5 1.02 LR_close
213 41 MA1118.1 SIX1 MA1118.1 GWAACCTGAKM SIX1 0.0136 4.19e-05 15600 93.1 70600 92.2 1.01 LR_close
214 8 MA1495.1 HOXA1 MA1495.1 STAATTAS HOXA1 0.015 4.62e-05 11000 65.4 48900 63.7 1.03 LR_close
215 21 MA0818.2 BHLHE22 MA0818.2 AMCATATGKY BHLHE22 0.018 5.5e-05 5050 30.1 21900 28.5 1.06 LR_close
216 27 MA1547.2 PITX2 MA1547.2 YTAATCCY PITX2 0.0203 6.17e-05 5610 33.5 24400 31.9 1.05 LR_close
217 10 MA0870.1 Sox1 MA0870.1 AACAATANCATTGTT Sox1 0.0204 6.19e-05 552 3.3 2080 2.71 1.22 LR_close
218 8 MA0618.1 LBX1 MA0618.1 TTAATTAG LBX1 0.0211 6.37e-05 10800 64.6 48300 63 1.03 LR_close
219 37 MA1535.1 NR2C1 MA1535.1 NRRGGTCAN NR2C1 0.0224 6.72e-05 14900 89 67300 87.8 1.01 LR_close
220 42 MA1975.1 ZNF214 MA1975.1 VWTCATCAABGTCCT ZNF214 0.0251 7.52e-05 12800 76.4 57400 74.9 1.02 LR_close
221 31 MA0806.1 TBX4 MA0806.1 AGGTGTGA TBX4 0.0275 8.15e-05 1760 10.5 7260 9.47 1.11 LR_close
222 31 MA0689.1 TBX20 MA0689.1 WAGGTGTGAAR TBX20 0.0275 8.15e-05 9800 58.5 43500 56.8 1.03 LR_close
223 21 MA0607.2 BHLHA15 MA0607.2 ACCATATGGT BHLHA15 0.0283 8.34e-05 4590 27.4 19800 25.9 1.06 LR_close
224 16 MA1638.1 HAND2 MA1638.1 NVCAGATGNN HAND2 0.03 8.8e-05 1590 9.51 6550 8.54 1.11 LR_close
225 19 MA0031.1 FOXD1 MA0031.1 GTAAACAW FOXD1 0.0405 0.000119 10800 64.4 48200 62.8 1.03 LR_close
226 40 MA1479.1 DMRTC2 MA1479.1 AATTGMTACATT DMRTC2 0.0419 0.000122 13200 78.9 59400 77.5 1.02 LR_close
227 8 MA1481.1 DRGX MA1481.1 YYAATTAN DRGX 0.0439 0.000127 13100 78.1 58800 76.7 1.02 LR_close
228 43 MA1623.1 Stat2 MA1623.1 RGAAACAGAAASH Stat2 0.0468 0.000135 15200 90.6 68700 89.6 1.01 LR_close
14 44 MA1107.2 (KLF9) MEME-3 ACACACACACACACA ACACACACACACACA KLF9 1.26 0.0902 22 0.13 68 0.09 1.53 LR_close
15 45 MA1723.1 (PRDM9) MEME-2 DGGRGVWGGGRRGAG DGGRGVWGGGRRGAG PRDM9 11.3 0.75 501 2.99 2340 3.05 0.982 LR_close
16 46 MA1125.1 (ZNF384) MEME-1 AAAAWAAAAAAARAA AAAAWAAAAAAARAA ZNF384 17 1 190 1.13 1100 1.44 0.792 LR_close
17 47 MA0139.1 (CTCF) MEME-4 SYGCCMYCTGSTGGY SYGCCMYCTGSTGGY CTCF 17 1 1890 11.3 10400 13.6 0.831 LR_close 
ER_rat <- 1.25
mrc_type <- "LR_close"
LR_close_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

LR_close_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP.`*2.5), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./2.5,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

meme_motifs_EAR_open <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_open_xstreme/xstreme.txt")
meme_motifs_ESR_open <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_open_xstreme/xstreme.txt")
meme_motifs_LR_open <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_open_xstreme/xstreme.txt")
meme_motifs_EAR_close <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_close_xstreme/xstreme.txt")
meme_motifs_ESR_close <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_close_xstreme/xstreme.txt")
meme_motifs_LR_close <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_close_xstreme/xstreme.txt")
meme_motifs_ESR_opcl <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_opcl_xstreme/xstreme.txt")
meme_motifs_ESR_clop <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_clop_xstreme/xstreme.txt")

sessionInfo()
R version 4.4.2 (2024-10-31 ucrt)
Platform: x86_64-w64-mingw32/x64
Running under: Windows 11 x64 (build 26100)

Matrix products: default


locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

time zone: America/Chicago
tzcode source: internal

attached base packages:
[1] grid      stats4    stats     graphics  grDevices utils     datasets 
[8] methods   base     

other attached packages:
 [1] motifmatchr_1.28.0                      
 [2] ggseqlogo_0.2                           
 [3] universalmotif_1.24.2                   
 [4] data.table_1.17.0                       
 [5] BSgenome.Hsapiens.UCSC.hg38_1.4.5       
 [6] BSgenome_1.74.0                         
 [7] BiocIO_1.16.0                           
 [8] MotifDb_1.48.0                          
 [9] Biostrings_2.74.1                       
[10] XVector_0.46.0                          
[11] TFBSTools_1.44.0                        
[12] JASPAR2022_0.99.8                       
[13] BiocFileCache_2.14.0                    
[14] dbplyr_2.5.0                            
[15] devtools_2.4.5                          
[16] usethis_3.1.0                           
[17] ggpubr_0.6.0                            
[18] BiocParallel_1.40.0                     
[19] Cormotif_1.52.0                         
[20] affy_1.84.0                             
[21] scales_1.3.0                            
[22] VennDiagram_1.7.3                       
[23] futile.logger_1.4.3                     
[24] gridExtra_2.3                           
[25] ggfortify_0.4.17                        
[26] edgeR_4.4.2                             
[27] limma_3.62.2                            
[28] rtracklayer_1.66.0                      
[29] org.Hs.eg.db_3.20.0                     
[30] TxDb.Hsapiens.UCSC.hg38.knownGene_3.20.0
[31] GenomicFeatures_1.58.0                  
[32] AnnotationDbi_1.68.0                    
[33] Biobase_2.66.0                          
[34] GenomicRanges_1.58.0                    
[35] GenomeInfoDb_1.42.3                     
[36] IRanges_2.40.1                          
[37] S4Vectors_0.44.0                        
[38] BiocGenerics_0.52.0                     
[39] ChIPseeker_1.42.1                       
[40] RColorBrewer_1.1-3                      
[41] broom_1.0.7                             
[42] kableExtra_1.4.0                        
[43] cowplot_1.1.3                           
[44] lubridate_1.9.4                         
[45] forcats_1.0.0                           
[46] stringr_1.5.1                           
[47] dplyr_1.1.4                             
[48] purrr_1.0.4                             
[49] readr_2.1.5                             
[50] tidyr_1.3.1                             
[51] tibble_3.2.1                            
[52] ggplot2_3.5.1                           
[53] tidyverse_2.0.0                         
[54] workflowr_1.7.1                         

loaded via a namespace (and not attached):
  [1] fs_1.6.5                               
  [2] matrixStats_1.5.0                      
  [3] bitops_1.0-9                           
  [4] DirichletMultinomial_1.48.0            
  [5] enrichplot_1.26.6                      
  [6] httr_1.4.7                             
  [7] profvis_0.4.0                          
  [8] tools_4.4.2                            
  [9] backports_1.5.0                        
 [10] R6_2.6.1                               
 [11] lazyeval_0.2.2                         
 [12] urlchecker_1.0.1                       
 [13] withr_3.0.2                            
 [14] preprocessCore_1.68.0                  
 [15] cli_3.6.4                              
 [16] formatR_1.14                           
 [17] labeling_0.4.3                         
 [18] sass_0.4.9                             
 [19] Rsamtools_2.22.0                       
 [20] systemfonts_1.2.1                      
 [21] yulab.utils_0.2.0                      
 [22] DOSE_4.0.0                             
 [23] svglite_2.1.3                          
 [24] R.utils_2.13.0                         
 [25] sessioninfo_1.2.3                      
 [26] plotrix_3.8-4                          
 [27] rstudioapi_0.17.1                      
 [28] RSQLite_2.3.9                          
 [29] generics_0.1.3                         
 [30] gridGraphics_0.5-1                     
 [31] TxDb.Hsapiens.UCSC.hg19.knownGene_3.2.2
 [32] gtools_3.9.5                           
 [33] car_3.1-3                              
 [34] GO.db_3.20.0                           
 [35] Matrix_1.7-3                           
 [36] abind_1.4-8                            
 [37] R.methodsS3_1.8.2                      
 [38] lifecycle_1.0.4                        
 [39] whisker_0.4.1                          
 [40] yaml_2.3.10                            
 [41] carData_3.0-5                          
 [42] SummarizedExperiment_1.36.0            
 [43] gplots_3.2.0                           
 [44] qvalue_2.38.0                          
 [45] SparseArray_1.6.2                      
 [46] blob_1.2.4                             
 [47] promises_1.3.2                         
 [48] pwalign_1.2.0                          
 [49] crayon_1.5.3                           
 [50] miniUI_0.1.1.1                         
 [51] ggtangle_0.0.6                         
 [52] lattice_0.22-6                         
 [53] annotate_1.84.0                        
 [54] KEGGREST_1.46.0                        
 [55] pillar_1.10.1                          
 [56] knitr_1.49                             
 [57] fgsea_1.32.2                           
 [58] rjson_0.2.23                           
 [59] boot_1.3-31                            
 [60] codetools_0.2-20                       
 [61] fastmatch_1.1-6                        
 [62] glue_1.8.0                             
 [63] getPass_0.2-4                          
 [64] ggfun_0.1.8                            
 [65] remotes_2.5.0                          
 [66] vctrs_0.6.5                            
 [67] png_0.1-8                              
 [68] treeio_1.30.0                          
 [69] poweRlaw_1.0.0                         
 [70] gtable_0.3.6                           
 [71] cachem_1.1.0                           
 [72] xfun_0.51                              
 [73] S4Arrays_1.6.0                         
 [74] mime_0.12                              
 [75] statmod_1.5.0                          
 [76] ellipsis_0.3.2                         
 [77] nlme_3.1-167                           
 [78] ggtree_3.14.0                          
 [79] bit64_4.6.0-1                          
 [80] filelock_1.0.3                         
 [81] rprojroot_2.0.4                        
 [82] bslib_0.9.0                            
 [83] affyio_1.76.0                          
 [84] KernSmooth_2.23-26                     
 [85] splitstackshape_1.4.8                  
 [86] seqLogo_1.72.0                         
 [87] colorspace_2.1-1                       
 [88] DBI_1.2.3                              
 [89] tidyselect_1.2.1                       
 [90] processx_3.8.6                         
 [91] bit_4.6.0                              
 [92] compiler_4.4.2                         
 [93] curl_6.2.1                             
 [94] git2r_0.35.0                           
 [95] xml2_1.3.7                             
 [96] DelayedArray_0.32.0                    
 [97] caTools_1.18.3                         
 [98] callr_3.7.6                            
 [99] digest_0.6.37                          
[100] rmarkdown_2.29                         
[101] htmltools_0.5.8.1                      
[102] pkgconfig_2.0.3                        
[103] MatrixGenerics_1.18.1                  
[104] fastmap_1.2.0                          
[105] rlang_1.1.5                            
[106] htmlwidgets_1.6.4                      
[107] UCSC.utils_1.2.0                       
[108] shiny_1.10.0                           
[109] farver_2.1.2                           
[110] jquerylib_0.1.4                        
[111] jsonlite_1.9.1                         
[112] GOSemSim_2.32.0                        
[113] R.oo_1.27.0                            
[114] RCurl_1.98-1.16                        
[115] magrittr_2.0.3                         
[116] Formula_1.2-5                          
[117] GenomeInfoDbData_1.2.13                
[118] ggplotify_0.1.2                        
[119] patchwork_1.3.0                        
[120] munsell_0.5.1                          
[121] Rcpp_1.0.14                            
[122] ape_5.8-1                              
[123] stringi_1.8.4                          
[124] MASS_7.3-65                            
[125] zlibbioc_1.52.0                        
[126] plyr_1.8.9                             
[127] pkgbuild_1.4.6                         
[128] parallel_4.4.2                         
[129] ggrepel_0.9.6                          
[130] CNEr_1.42.0                            
[131] splines_4.4.2                          
[132] hms_1.1.3                              
[133] locfit_1.5-9.12                        
[134] ps_1.9.0                               
[135] igraph_2.1.4                           
[136] ggsignif_0.6.4                         
[137] reshape2_1.4.4                         
[138] pkgload_1.4.0                          
[139] TFMPvalue_0.0.9                        
[140] futile.options_1.0.1                   
[141] XML_3.99-0.18                          
[142] evaluate_1.0.3                         
[143] lambda.r_1.2.4                         
[144] BiocManager_1.30.25                    
[145] tzdb_0.4.0                             
[146] httpuv_1.6.15                          
[147] xtable_1.8-4                           
[148] restfulr_0.0.15                        
[149] tidytree_0.4.6                         
[150] rstatix_0.7.2                          
[151] later_1.4.1                            
[152] viridisLite_0.4.2                      
[153] aplot_0.2.5                            
[154] memoise_2.0.1                          
[155] GenomicAlignments_1.42.0               
[156] timechange_0.3.0