GO and KEGG pathway analysis

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Last updated: 2024-05-28

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Knit directory: ATAC_learning/

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Ignored files:
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Untracked files:
    Untracked:  EAR_2_plot.pdf
    Untracked:  ESR_1_plot.pdf
    Untracked:  Firstcorr plotATAC.pdf
    Untracked:  IND1_2_3_6_corrplot.pdf
    Untracked:  LR_3_plot.pdf
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    Untracked:  trimmed_Ind1_75DA24h_S7.nodup.fragment.size.distribution.pdf
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Unstaged changes:
    Modified:   analysis/CorMotif_data_n45.Rmd
    Modified:   analysis/Enhancer_files.Rmd
    Modified:   analysis/Enrichment_motif.Rmd
    Modified:   analysis/Jaspar_motif.Rmd
    Modified:   analysis/Peak_analysis.Rmd
    Modified:   analysis/Smaller_set_DAR.Rmd

Note that any generated files, e.g. HTML, png, CSS, etc., are not included in this status report because it is ok for generated content to have uncommitted changes.

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These are the previous versions of the repository in which changes were made to the R Markdown (analysis/GO_KEGG_analysis.Rmd) and HTML (docs/GO_KEGG_analysis.html) files. If you’ve configured a remote Git repository (see ?wflow_git_remote), click on the hyperlinks in the table below to view the files as they were in that past version.

File	Version	Author	Date	Message
Rmd	5c6ef83	reneeisnowhere	2024-05-28	updates to KEGG/GO 20kb lists
html	d1a3829	reneeisnowhere	2024-05-17	Build site.
Rmd	9fb4f9a	reneeisnowhere	2024-05-17	adding in updates from Neargenes and enhncers
html	2d991d7	reneeisnowhere	2024-05-03	Build site.
Rmd	f57f2ee	reneeisnowhere	2024-05-03	first update

---

library(tidyverse)
# library(ggsignif)
# library(cowplot)
# library(ggpubr)

# library(sjmisc)
library(kableExtra)
library(broom)
# library(biomaRt)
library(RColorBrewer)
library(gprofiler2)
# library(qvalue)
library(ChIPseeker)
library("TxDb.Hsapiens.UCSC.hg38.knownGene")
library("org.Hs.eg.db")
# library(ATACseqQC)
library(rtracklayer)
library(edgeR)
library(ggfortify)
library(limma)
library(readr)
library(BiocGenerics)
library(gridExtra)
library(VennDiagram)
library(scales)
# library(ggVennDiagram)
# library(Cormotif)
library(BiocParallel)
library(ggpubr)
# library(devtools)
# # install_github('davetang/bedr')
# library(bedr)
library(biomaRt)

data loading

peakAnnoList_n45_motif <- readRDS("data/peakAnnoList_n45_motif.RDS")
# list2env(peakAnnoList_n45_motif, envir = .GlobalEnv)

EAR_df <- as.data.frame(peakAnnoList_n45_motif$EAR_n45_gr)
EAR_df_gr <-  GRanges(EAR_df)

ESR_df <- as.data.frame(peakAnnoList_n45_motif$ESR_n45_gr)
ESR_df_gr <-  GRanges(ESR_df)
 
LR_df <- as.data.frame(peakAnnoList_n45_motif$LR_n45_gr)
LR_df_gr <-  GRanges(LR_df)
 
NR_df <- as.data.frame(peakAnnoList_n45_motif$NR_n45_gr)
NR_df_gr <-  GRanges(NR_df)


exp_neargene_table <- read_delim("data/n45_bedfiles/exp_neargene_table.tsv", 
    delim = "\t", escape_double = FALSE, 
    trim_ws = TRUE)

# col_ng_peak <- exp_neargene_table %>%
#   group_by(chr, start, end, peakid) %>%
#     summarise(NCBI_gene = paste(unique(ENTREZID),collapse=","),
#               ensembl_ID= paste(unique(ensembl_id),collapse = ","),
#               SYMBOL= paste(unique(SYMBOL),collapse = ",") , 
#               dist_to_NG =min(dist_to_NG))
# 

EAR_NG_list <- exp_neargene_table %>% 
    dplyr::filter(peakid %in% EAR_df$id) %>%
  dplyr::filter(dist_to_NG<20000) %>% 
  dplyr::select(ENTREZID) %>% 
  distinct()

ESR_NG_list <- exp_neargene_table %>% 
    dplyr::filter(peakid %in% ESR_df$id) %>% 
   dplyr::filter(dist_to_NG<20000) %>% 
  dplyr::select(ENTREZID) %>% 
  distinct()

LR_NG_list <- exp_neargene_table %>% 
    dplyr::filter(peakid %in% LR_df$id) %>%
   dplyr::filter(dist_to_NG<20000) %>% 
  dplyr::select(ENTREZID) %>% 
  distinct()

NR_NG_list <- exp_neargene_table %>% 
    dplyr::filter(peakid %in% NR_df$id) %>% 
   dplyr::filter(dist_to_NG<20000) %>% 
  dplyr::select(ENTREZID) %>% 
  distinct()

background_df <- exp_neargene_table %>% 
  dplyr::select(ENTREZID) %>% 
  distinct()

EAR_resgenes <- readRDS("data/GO_KEGG_analysis/EAR_resgenes.RDS")
ESR_resgenes <- readRDS("data/GO_KEGG_analysis/ESR_resgenes.RDS")
LR_resgenes <- readRDS("data/GO_KEGG_analysis/LR_resgenes.RDS")
NR_resgenes <- readRDS("data/GO_KEGG_analysis/NR_resgenes.RDS")

EAR_enh_peaks_20k <- readRDS("data/enhancerdata/EAR_enh_peaks_20k.RDS")
ESR_enh_peaks_20k <- readRDS("data/enhancerdata/ESR_enh_peaks_20k.RDS")
LR_enh_peaks_20k <- readRDS("data/enhancerdata/LR_enh_peaks_20k.RDS")
NR_enh_peaks_20k <- readRDS("data/enhancerdata/NR_enh_peaks_20k.RDS")

EAR_resgenes_20k <- readRDS("data/GO_KEGG_analysis/EAR_resgenes_20k.RDS")
EAR_resgenes_20k_enh <- readRDS("data/GO_KEGG_analysis/EAR_resgenes_20k_enh.RDS")
ESR_resgenes_20k <- readRDS("data/GO_KEGG_analysis/ESR_resgenes_20k.RDS")
ESR_resgenes_20k_enh <- readRDS("data/GO_KEGG_analysis/ESR_resgenes_20k_enh.RDS")

LR_resgenes_20k <- readRDS("data/GO_KEGG_analysis/LR_resgenes_20k.RDS")
LR_resgenes_20k_enh <- readRDS("data/GO_KEGG_analysis/LR_resgenes_20k_enh.RDS")

NR_resgenes_20k <- readRDS("data/GO_KEGG_analysis/NR_resgenes_20k.RDS")
NR_resgenes_20k_enh <- readRDS("data/GO_KEGG_analysis/NR_resgenes_20k_enh.RDS")

EAR response genes

# EAR_resgenes <- gost(query = EAR_NG_list$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(EAR_resgenes,"data/GO_KEGG_analysis/EAR_resgenes.RDS")


EARnom <- gostplot(EAR_resgenes, capped = FALSE, interactive = TRUE)
# EARnom

EARnomtable <- EAR_resgenes$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

EARnomtable %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in EAR neargenes" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in EAR neargenes

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0009653	anatomical structure morphogenesis	898	1844	4.11e-28
GO:BP	GO:0032502	developmental process	1806	4179	6.83e-26
GO:BP	GO:0048856	anatomical structure development	1683	3867	2.86e-25
GO:BP	GO:0007275	multicellular organism development	1413	3170	3.48e-25
GO:BP	GO:0032501	multicellular organismal process	1918	4504	2.88e-24
GO:BP	GO:0048869	cellular developmental process	1262	2804	8.92e-24
GO:BP	GO:0030154	cell differentiation	1261	2803	1.02e-23
GO:BP	GO:0050793	regulation of developmental process	809	1697	7.18e-22
GO:BP	GO:0048731	system development	1211	2719	1.94e-20
GO:BP	GO:0016477	cell migration	515	1011	3.91e-20
GO:BP	GO:0051239	regulation of multicellular organismal process	890	1924	1.81e-19
GO:BP	GO:0007154	cell communication	1686	3983	1.59e-18
GO:BP	GO:0023052	signaling	1660	3918	2.46e-18
GO:BP	GO:0048699	generation of neurons	535	1076	3.58e-18
GO:BP	GO:0040012	regulation of locomotion	380	720	1.16e-17
GO:BP	GO:0030334	regulation of cell migration	357	668	1.16e-17
GO:BP	GO:2000145	regulation of cell motility	371	700	1.19e-17
GO:BP	GO:0048870	cell motility	549	1120	4.10e-17
GO:BP	GO:0009887	animal organ morphogenesis	357	673	4.96e-17
GO:BP	GO:0007165	signal transduction	1534	3611	5.22e-17
GO:BP	GO:0022008	neurogenesis	602	1251	8.71e-17
GO:BP	GO:0040011	locomotion	413	805	1.25e-16
GO:BP	GO:0072359	circulatory system development	438	864	1.52e-16
GO:BP	GO:0030182	neuron differentiation	500	1014	4.14e-16
GO:BP	GO:0048513	animal organ development	901	2004	1.36e-15
GO:BP	GO:0050789	regulation of biological process	2957	7516	2.09e-15
GO:BP	GO:0009888	tissue development	634	1348	4.41e-15
GO:BP	GO:2000026	regulation of multicellular organismal development	469	951	4.83e-15
GO:BP	GO:0051094	positive regulation of developmental process	452	913	8.19e-15
GO:BP	GO:0050794	regulation of cellular process	2823	7153	8.19e-15
GO:BP	GO:0065007	biological regulation	3028	7734	1.41e-14
GO:BP	GO:0045595	regulation of cell differentiation	517	1073	2.39e-14
GO:BP	GO:0051716	cellular response to stimulus	1900	4640	4.73e-14
GO:BP	GO:0048468	cell development	845	1886	4.95e-14
GO:BP	GO:0048519	negative regulation of biological process	1571	3764	4.95e-14
GO:BP	GO:0007155	cell adhesion	460	941	5.94e-14
GO:BP	GO:0007399	nervous system development	800	1775	6.41e-14
GO:BP	GO:0009790	embryo development	409	821	6.86e-14
GO:BP	GO:0050896	response to stimulus	2170	5379	1.18e-13
GO:BP	GO:0048523	negative regulation of cellular process	1486	3550	1.59e-13
GO:BP	GO:0035239	tube morphogenesis	328	638	3.14e-13
GO:BP	GO:0048518	positive regulation of biological process	1766	4301	3.91e-13
GO:BP	GO:0035295	tube development	391	787	5.10e-13
GO:BP	GO:0034330	cell junction organization	286	545	7.88e-13
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	411	837	9.46e-13
GO:BP	GO:0007423	sensory organ development	215	387	1.12e-12
GO:BP	GO:0048522	positive regulation of cellular process	1631	3954	1.57e-12
GO:BP	GO:0010646	regulation of cell communication	1054	2444	1.80e-12
GO:BP	GO:0048666	neuron development	408	838	5.95e-12
GO:BP	GO:0003008	system process	532	1139	7.86e-12
GO:BP	GO:0023051	regulation of signaling	1047	2438	8.93e-12
GO:BP	GO:0045597	positive regulation of cell differentiation	302	591	9.93e-12
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	309	609	1.58e-11
GO:BP	GO:0031175	neuron projection development	366	743	1.67e-11
GO:BP	GO:0035556	intracellular signal transduction	854	1951	2.38e-11
GO:BP	GO:0009966	regulation of signal transduction	938	2166	2.52e-11
GO:BP	GO:0048598	embryonic morphogenesis	226	422	3.57e-11
GO:BP	GO:0141124	intracellular signaling cassette	599	1314	4.36e-11
GO:BP	GO:0000902	cell morphogenesis	351	713	5.76e-11
GO:BP	GO:0001501	skeletal system development	191	347	9.68e-11
GO:BP	GO:0001944	vasculature development	280	552	2.24e-10
GO:BP	GO:0051093	negative regulation of developmental process	310	622	2.24e-10
GO:BP	GO:0030900	forebrain development	155	272	3.85e-10
GO:BP	GO:0001568	blood vessel development	267	525	5.12e-10
GO:BP	GO:0031344	regulation of cell projection organization	262	516	1.02e-09
GO:BP	GO:0065008	regulation of biological quality	820	1893	1.15e-09
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	257	505	1.15e-09
GO:BP	GO:0007166	cell surface receptor signaling pathway	784	1801	1.15e-09
GO:BP	GO:0010975	regulation of neuron projection development	191	355	1.34e-09
GO:BP	GO:0060429	epithelium development	377	792	2.17e-09
GO:BP	GO:0007507	heart development	253	499	2.66e-09
GO:BP	GO:0048514	blood vessel morphogenesis	231	450	4.42e-09
GO:BP	GO:0007267	cell-cell signaling	494	1082	4.64e-09
GO:BP	GO:0007417	central nervous system development	334	694	6.43e-09
GO:BP	GO:0048589	developmental growth	252	501	7.88e-09
GO:BP	GO:0051128	regulation of cellular component organization	802	1862	7.88e-09
GO:BP	GO:0048729	tissue morphogenesis	231	453	9.50e-09
GO:BP	GO:0051240	positive regulation of multicellular organismal process	475	1040	1.03e-08
GO:BP	GO:0048812	neuron projection morphogenesis	242	479	1.06e-08
GO:BP	GO:0030155	regulation of cell adhesion	254	508	1.35e-08
GO:BP	GO:0001503	ossification	164	302	1.35e-08
GO:BP	GO:0048583	regulation of response to stimulus	1130	2717	1.35e-08
GO:BP	GO:0071495	cellular response to endogenous stimulus	472	1035	1.47e-08
GO:BP	GO:0034329	cell junction assembly	173	323	1.74e-08
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	247	494	2.33e-08
GO:BP	GO:0009967	positive regulation of signal transduction	494	1093	2.57e-08
GO:BP	GO:0030030	cell projection organization	529	1182	3.41e-08
GO:BP	GO:0048858	cell projection morphogenesis	248	498	3.42e-08
GO:BP	GO:0014706	striated muscle tissue development	122	213	3.92e-08
GO:BP	GO:0045596	negative regulation of cell differentiation	228	452	4.03e-08
GO:BP	GO:0060322	head development	265	539	4.21e-08
GO:BP	GO:0070848	response to growth factor	268	547	5.16e-08
GO:BP	GO:0048738	cardiac muscle tissue development	116	201	5.44e-08
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	220	435	5.88e-08
GO:BP	GO:0010647	positive regulation of cell communication	541	1218	7.89e-08
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	338	717	8.14e-08
GO:BP	GO:0023056	positive regulation of signaling	542	1221	8.33e-08
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	513	1150	1.06e-07
GO:BP	GO:0071363	cellular response to growth factor stimulus	258	528	1.43e-07
GO:BP	GO:0007420	brain development	245	498	1.69e-07
GO:BP	GO:0061061	muscle structure development	261	536	1.72e-07
GO:BP	GO:0043583	ear development	91	151	1.85e-07
GO:BP	GO:0048880	sensory system development	144	266	1.96e-07
GO:BP	GO:0032989	cellular anatomical entity morphogenesis	282	588	2.55e-07
GO:BP	GO:0090596	sensory organ morphogenesis	101	173	2.72e-07
GO:BP	GO:0001525	angiogenesis	194	381	2.81e-07
GO:BP	GO:0001654	eye development	142	263	3.07e-07
GO:BP	GO:0030336	negative regulation of cell migration	118	210	3.07e-07
GO:BP	GO:2000146	negative regulation of cell motility	121	217	3.59e-07
GO:BP	GO:0150063	visual system development	142	264	4.21e-07
GO:BP	GO:0002062	chondrocyte differentiation	59	88	4.53e-07
GO:BP	GO:0001667	ameboidal-type cell migration	177	344	4.89e-07
GO:BP	GO:0060284	regulation of cell development	273	570	5.02e-07
GO:BP	GO:0051216	cartilage development	87	145	5.09e-07
GO:BP	GO:0009719	response to endogenous stimulus	527	1197	5.36e-07
GO:BP	GO:0010631	epithelial cell migration	132	243	6.17e-07
GO:BP	GO:0090132	epithelium migration	132	243	6.17e-07
GO:BP	GO:0098609	cell-cell adhesion	270	564	6.20e-07
GO:BP	GO:0040007	growth	325	697	6.25e-07
GO:BP	GO:0001764	neuron migration	79	129	6.61e-07
GO:BP	GO:0060537	muscle tissue development	174	339	7.73e-07
GO:BP	GO:0050808	synapse organization	173	337	8.34e-07
GO:BP	GO:0003013	circulatory system process	211	426	9.64e-07
GO:BP	GO:0008283	cell population proliferation	568	1306	1.06e-06
GO:BP	GO:0042221	response to chemical	955	2304	1.08e-06
GO:BP	GO:0040013	negative regulation of locomotion	131	243	1.22e-06
GO:BP	GO:0002009	morphogenesis of an epithelium	186	369	1.35e-06
GO:BP	GO:0007409	axonogenesis	172	337	1.51e-06
GO:BP	GO:1902531	regulation of intracellular signal transduction	560	1289	1.56e-06
GO:BP	GO:0048839	inner ear development	80	133	1.56e-06
GO:BP	GO:0061564	axon development	187	372	1.56e-06
GO:BP	GO:0060021	roof of mouth development	48	69	1.71e-06
GO:BP	GO:0051241	negative regulation of multicellular organismal process	326	706	1.89e-06
GO:BP	GO:0090130	tissue migration	132	247	2.04e-06
GO:BP	GO:0016358	dendrite development	103	183	2.18e-06
GO:BP	GO:0010632	regulation of epithelial cell migration	105	188	2.76e-06
GO:BP	GO:2000147	positive regulation of cell motility	201	408	3.29e-06
GO:BP	GO:0040017	positive regulation of locomotion	204	416	4.07e-06
GO:BP	GO:0030335	positive regulation of cell migration	195	395	4.26e-06
GO:BP	GO:0030029	actin filament-based process	297	640	4.36e-06
GO:BP	GO:0044057	regulation of system process	190	384	5.04e-06
GO:BP	GO:0048568	embryonic organ development	155	303	5.70e-06
GO:BP	GO:0042127	regulation of cell population proliferation	472	1077	6.07e-06
GO:BP	GO:0048732	gland development	157	308	6.25e-06
GO:BP	GO:0003007	heart morphogenesis	117	218	8.62e-06
GO:BP	GO:0061448	connective tissue development	111	205	9.75e-06
GO:BP	GO:0048705	skeletal system morphogenesis	85	148	9.75e-06
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	219	456	1.01e-05
GO:BP	GO:0016055	Wnt signaling pathway	177	358	1.44e-05
GO:BP	GO:0007389	pattern specification process	146	286	1.52e-05
GO:BP	GO:0043408	regulation of MAPK cascade	206	427	1.53e-05
GO:BP	GO:0070887	cellular response to chemical stimulus	732	1751	1.58e-05
GO:BP	GO:0198738	cell-cell signaling by wnt	177	359	1.79e-05
GO:BP	GO:0007264	small GTPase-mediated signal transduction	190	390	1.90e-05
GO:BP	GO:0060411	cardiac septum morphogenesis	45	67	2.05e-05
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	985	2415	2.05e-05
GO:BP	GO:0043010	camera-type eye development	121	230	2.05e-05
GO:BP	GO:0007411	axon guidance	95	172	2.13e-05
GO:BP	GO:0097485	neuron projection guidance	95	172	2.13e-05
GO:BP	GO:0048584	positive regulation of response to stimulus	635	1504	2.24e-05
GO:BP	GO:0060560	developmental growth involved in morphogenesis	103	190	2.32e-05
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	897	2186	2.42e-05
GO:BP	GO:0010033	response to organic substance	724	1736	2.71e-05
GO:BP	GO:0021537	telencephalon development	105	195	2.73e-05
GO:BP	GO:0030111	regulation of Wnt signaling pathway	134	261	2.87e-05
GO:BP	GO:0050807	regulation of synapse organization	95	173	2.92e-05
GO:BP	GO:0009952	anterior/posterior pattern specification	71	121	2.99e-05
GO:BP	GO:0051146	striated muscle cell differentiation	122	234	3.23e-05
GO:BP	GO:0016043	cellular component organization	1874	4802	3.24e-05
GO:BP	GO:0050803	regulation of synapse structure or activity	96	176	3.77e-05
GO:BP	GO:0001649	osteoblast differentiation	95	174	4.04e-05
GO:BP	GO:0009987	cellular process	3975	10686	4.12e-05
GO:BP	GO:0042692	muscle cell differentiation	160	323	4.12e-05
GO:BP	GO:0050877	nervous system process	275	600	4.21e-05
GO:BP	GO:0031589	cell-substrate adhesion	132	258	4.23e-05
GO:BP	GO:0048588	developmental cell growth	97	179	4.75e-05
GO:BP	GO:0034762	regulation of transmembrane transport	149	298	4.85e-05
GO:BP	GO:0008015	blood circulation	174	357	5.05e-05
GO:BP	GO:0050890	cognition	112	213	5.11e-05
GO:BP	GO:0000165	MAPK cascade	235	504	5.53e-05
GO:BP	GO:0045785	positive regulation of cell adhesion	150	301	5.61e-05
GO:BP	GO:0035265	organ growth	73	127	5.74e-05
GO:BP	GO:0071840	cellular component organization or biogenesis	1939	4988	5.76e-05
GO:BP	GO:0099536	synaptic signaling	226	483	6.35e-05
GO:BP	GO:0035313	wound healing, spreading of epidermal cells	16	17	6.38e-05
GO:BP	GO:0006468	protein phosphorylation	417	958	7.02e-05
GO:BP	GO:0009893	positive regulation of metabolic process	1057	2622	7.62e-05
GO:BP	GO:0045664	regulation of neuron differentiation	74	130	7.84e-05
GO:BP	GO:0045444	fat cell differentiation	96	179	9.34e-05
GO:BP	GO:0010648	negative regulation of cell communication	446	1034	9.54e-05
GO:BP	GO:0048592	eye morphogenesis	63	107	9.78e-05
GO:BP	GO:0051960	regulation of nervous system development	165	339	9.94e-05
GO:BP	GO:0048638	regulation of developmental growth	124	243	9.94e-05
GO:BP	GO:0051130	positive regulation of cellular component organization	373	850	1.00e-04
GO:BP	GO:0008285	negative regulation of cell population proliferation	219	469	1.06e-04
GO:BP	GO:0048762	mesenchymal cell differentiation	105	200	1.12e-04
GO:BP	GO:0031401	positive regulation of protein modification process	252	550	1.14e-04
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	382	874	1.18e-04
GO:BP	GO:0071310	cellular response to organic substance	548	1297	1.20e-04
GO:BP	GO:0009792	embryo development ending in birth or egg hatching	240	521	1.20e-04
GO:BP	GO:0072001	renal system development	124	244	1.25e-04
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	119	233	1.44e-04
GO:BP	GO:0023057	negative regulation of signaling	445	1036	1.58e-04
GO:BP	GO:0035051	cardiocyte differentiation	74	132	1.58e-04
GO:BP	GO:0030855	epithelial cell differentiation	201	428	1.66e-04
GO:BP	GO:0099537	trans-synaptic signaling	217	467	1.71e-04
GO:BP	GO:0099177	regulation of trans-synaptic signaling	157	323	1.82e-04
GO:BP	GO:0044087	regulation of cellular component biogenesis	334	757	1.87e-04
GO:BP	GO:0010720	positive regulation of cell development	151	309	1.89e-04
GO:BP	GO:0060412	ventricular septum morphogenesis	29	40	1.92e-04
GO:BP	GO:0045637	regulation of myeloid cell differentiation	75	135	2.07e-04
GO:BP	GO:0050673	epithelial cell proliferation	147	300	2.07e-04
GO:BP	GO:0031346	positive regulation of cell projection organization	141	286	2.13e-04
GO:BP	GO:0003002	regionalization	129	258	2.19e-04
GO:BP	GO:0055007	cardiac muscle cell differentiation	61	105	2.32e-04
GO:BP	GO:0010810	regulation of cell-substrate adhesion	87	162	2.32e-04
GO:BP	GO:0050804	modulation of chemical synaptic transmission	156	322	2.36e-04
GO:BP	GO:0045165	cell fate commitment	82	151	2.42e-04
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	105	203	2.45e-04
GO:BP	GO:0007369	gastrulation	77	140	2.47e-04
GO:BP	GO:0050770	regulation of axonogenesis	70	125	2.83e-04
GO:BP	GO:0043009	chordate embryonic development	232	507	2.89e-04
GO:BP	GO:0051049	regulation of transport	467	1098	2.89e-04
GO:BP	GO:1903706	regulation of hemopoiesis	128	257	2.92e-04
GO:BP	GO:0035107	appendage morphogenesis	63	110	2.96e-04
GO:BP	GO:0035108	limb morphogenesis	63	110	2.96e-04
GO:BP	GO:0050767	regulation of neurogenesis	142	290	2.96e-04
GO:BP	GO:0003206	cardiac chamber morphogenesis	63	110	2.96e-04
GO:BP	GO:0042592	homeostatic process	482	1137	3.01e-04
GO:BP	GO:0022612	gland morphogenesis	55	93	3.04e-04
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	124	248	3.09e-04
GO:BP	GO:0043410	positive regulation of MAPK cascade	141	288	3.14e-04
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	315	714	3.22e-04
GO:BP	GO:0007610	behavior	196	420	3.22e-04
GO:BP	GO:0002063	chondrocyte development	19	23	3.51e-04
GO:BP	GO:0008150	biological_process	4156	11244	3.65e-04
GO:BP	GO:0016049	cell growth	180	382	3.65e-04
GO:BP	GO:0065009	regulation of molecular function	544	1299	3.81e-04
GO:BP	GO:0048562	embryonic organ morphogenesis	95	182	3.84e-04
GO:BP	GO:0099175	regulation of postsynapse organization	49	81	3.87e-04
GO:BP	GO:0030036	actin cytoskeleton organization	255	566	3.90e-04
GO:BP	GO:0007611	learning or memory	98	189	3.97e-04
GO:BP	GO:0002761	regulation of myeloid leukocyte differentiation	48	79	3.98e-04
GO:BP	GO:0045667	regulation of osteoblast differentiation	57	98	4.00e-04
GO:BP	GO:0007268	chemical synaptic transmission	213	463	4.07e-04
GO:BP	GO:0098916	anterograde trans-synaptic signaling	213	463	4.07e-04
GO:BP	GO:0048813	dendrite morphogenesis	63	111	4.09e-04
GO:BP	GO:0030097	hemopoiesis	278	624	4.34e-04
GO:BP	GO:0003281	ventricular septum development	43	69	4.57e-04
GO:BP	GO:0010633	negative regulation of epithelial cell migration	34	51	4.71e-04
GO:BP	GO:0031325	positive regulation of cellular metabolic process	938	2333	4.73e-04
GO:BP	GO:0060041	retina development in camera-type eye	60	105	4.89e-04
GO:BP	GO:0099173	postsynapse organization	79	147	5.18e-04
GO:BP	GO:0060173	limb development	74	136	5.42e-04
GO:BP	GO:0048736	appendage development	74	136	5.42e-04
GO:BP	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	69	125	5.53e-04
GO:BP	GO:0021953	central nervous system neuron differentiation	57	99	5.80e-04
GO:BP	GO:0001822	kidney development	118	237	5.92e-04
GO:BP	GO:0022604	regulation of cell morphogenesis	99	193	6.04e-04
GO:BP	GO:2001222	regulation of neuron migration	27	38	6.25e-04
GO:BP	GO:0060070	canonical Wnt signaling pathway	120	242	6.32e-04
GO:BP	GO:0070372	regulation of ERK1 and ERK2 cascade	91	175	6.56e-04
GO:BP	GO:0008360	regulation of cell shape	60	106	7.00e-04
GO:BP	GO:0060348	bone development	78	146	7.47e-04
GO:BP	GO:0050772	positive regulation of axonogenesis	40	64	7.85e-04
GO:BP	GO:0003279	cardiac septum development	58	102	7.85e-04
GO:BP	GO:0055017	cardiac muscle tissue growth	40	64	7.85e-04
GO:BP	GO:0021543	pallium development	73	135	7.85e-04
GO:BP	GO:0035113	embryonic appendage morphogenesis	51	87	7.88e-04
GO:BP	GO:0030326	embryonic limb morphogenesis	51	87	7.88e-04
GO:BP	GO:0006811	monoatomic ion transport	314	719	7.89e-04
GO:BP	GO:0016310	phosphorylation	481	1145	8.12e-04
GO:BP	GO:0048645	animal organ formation	34	52	8.12e-04
GO:BP	GO:0003205	cardiac chamber development	80	151	8.43e-04
GO:BP	GO:0032879	regulation of localization	594	1439	9.38e-04
GO:BP	GO:0009968	negative regulation of signal transduction	413	972	9.46e-04
GO:BP	GO:0032924	activin receptor signaling pathway	24	33	9.46e-04
GO:BP	GO:0042476	odontogenesis	47	79	9.46e-04
GO:BP	GO:1901888	regulation of cell junction assembly	82	156	9.60e-04
GO:BP	GO:0031399	regulation of protein modification process	389	911	9.67e-04
GO:BP	GO:0002521	leukocyte differentiation	173	371	9.70e-04
GO:BP	GO:0030198	extracellular matrix organization	111	223	9.80e-04
GO:BP	GO:0050678	regulation of epithelial cell proliferation	122	249	1.01e-03
GO:BP	GO:0007416	synapse assembly	73	136	1.03e-03
GO:BP	GO:0008038	neuron recognition	25	35	1.03e-03
GO:BP	GO:0060562	epithelial tube morphogenesis	127	261	1.04e-03
GO:BP	GO:0071407	cellular response to organic cyclic compound	176	379	1.08e-03
GO:BP	GO:1990138	neuron projection extension	72	134	1.10e-03
GO:BP	GO:0070169	positive regulation of biomineral tissue development	26	37	1.11e-03
GO:BP	GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	126	259	1.12e-03
GO:BP	GO:0048663	neuron fate commitment	20	26	1.15e-03
GO:BP	GO:0060485	mesenchyme development	120	245	1.16e-03
GO:BP	GO:0045778	positive regulation of ossification	27	39	1.18e-03
GO:BP	GO:0034220	monoatomic ion transmembrane transport	260	587	1.18e-03
GO:BP	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	50	86	1.18e-03
GO:BP	GO:0043062	extracellular structure organization	111	224	1.19e-03
GO:BP	GO:0045229	external encapsulating structure organization	111	224	1.19e-03
GO:BP	GO:0022029	telencephalon cell migration	28	41	1.22e-03
GO:BP	GO:0051247	positive regulation of protein metabolic process	388	911	1.22e-03
GO:BP	GO:0007612	learning	61	110	1.23e-03
GO:BP	GO:0021885	forebrain cell migration	29	43	1.26e-03
GO:BP	GO:0048660	regulation of smooth muscle cell proliferation	55	97	1.27e-03
GO:BP	GO:1903522	regulation of blood circulation	98	194	1.27e-03
GO:BP	GO:0045666	positive regulation of neuron differentiation	36	57	1.29e-03
GO:BP	GO:0044319	wound healing, spreading of cells	21	28	1.32e-03
GO:BP	GO:0090505	epiboly involved in wound healing	21	28	1.32e-03
GO:BP	GO:0014070	response to organic cyclic compound	267	606	1.40e-03
GO:BP	GO:0043269	regulation of monoatomic ion transport	135	282	1.49e-03
GO:BP	GO:0060996	dendritic spine development	45	76	1.49e-03
GO:BP	GO:0001823	mesonephros development	44	74	1.57e-03
GO:BP	GO:0001508	action potential	57	102	1.58e-03
GO:BP	GO:0045995	regulation of embryonic development	43	72	1.63e-03
GO:BP	GO:0001657	ureteric bud development	43	72	1.63e-03
GO:BP	GO:0030501	positive regulation of bone mineralization	23	32	1.67e-03
GO:BP	GO:0072073	kidney epithelium development	61	111	1.67e-03
GO:BP	GO:0048593	camera-type eye morphogenesis	50	87	1.67e-03
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	511	1231	1.67e-03
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	209	463	1.67e-03
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	209	463	1.67e-03
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	512	1234	1.72e-03
GO:BP	GO:0030879	mammary gland development	55	98	1.76e-03
GO:BP	GO:0010717	regulation of epithelial to mesenchymal transition	49	85	1.76e-03
GO:BP	GO:0021795	cerebral cortex cell migration	24	34	1.81e-03
GO:BP	GO:0031345	negative regulation of cell projection organization	76	145	1.84e-03
GO:BP	GO:0086003	cardiac muscle cell contraction	39	64	1.87e-03
GO:BP	GO:0045216	cell-cell junction organization	79	152	1.92e-03
GO:BP	GO:0033002	muscle cell proliferation	79	152	1.92e-03
GO:BP	GO:0010463	mesenchymal cell proliferation	25	36	1.92e-03
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	104	210	1.94e-03
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	104	210	1.94e-03
GO:BP	GO:0040008	regulation of growth	208	462	2.02e-03
GO:BP	GO:0070371	ERK1 and ERK2 cascade	97	194	2.12e-03
GO:BP	GO:0010718	positive regulation of epithelial to mesenchymal transition	31	48	2.21e-03
GO:BP	GO:0051254	positive regulation of RNA metabolic process	557	1354	2.22e-03
GO:BP	GO:0009892	negative regulation of metabolic process	841	2100	2.23e-03
GO:BP	GO:0072164	mesonephric tubule development	43	73	2.39e-03
GO:BP	GO:0048706	embryonic skeletal system development	43	73	2.39e-03
GO:BP	GO:0072163	mesonephric epithelium development	43	73	2.39e-03
GO:BP	GO:0009611	response to wounding	175	382	2.44e-03
GO:BP	GO:0060419	heart growth	42	71	2.51e-03
GO:BP	GO:0043542	endothelial cell migration	88	174	2.64e-03
GO:BP	GO:0035270	endocrine system development	48	84	2.68e-03
GO:BP	GO:0030001	metal ion transport	232	524	2.76e-03
GO:BP	GO:0031214	biomineral tissue development	58	106	2.76e-03
GO:BP	GO:0032970	regulation of actin filament-based process	141	300	2.76e-03
GO:BP	GO:0150115	cell-substrate junction organization	53	95	2.76e-03
GO:BP	GO:0048675	axon extension	53	95	2.76e-03
GO:BP	GO:0090504	epiboly	21	29	2.77e-03
GO:BP	GO:0003231	cardiac ventricle development	62	115	2.81e-03
GO:BP	GO:0003170	heart valve development	39	65	2.83e-03
GO:BP	GO:0060571	morphogenesis of an epithelial fold	13	15	2.91e-03
GO:BP	GO:0045598	regulation of fat cell differentiation	52	93	2.92e-03
GO:BP	GO:0008284	positive regulation of cell population proliferation	264	605	3.00e-03
GO:BP	GO:0007517	muscle organ development	127	267	3.09e-03
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	741	1841	3.11e-03
GO:BP	GO:0055006	cardiac cell development	45	78	3.12e-03
GO:BP	GO:0044093	positive regulation of molecular function	334	783	3.20e-03
GO:BP	GO:0033993	response to lipid	251	573	3.25e-03
GO:BP	GO:0051179	localization	1448	3731	3.27e-03
GO:BP	GO:0018210	peptidyl-threonine modification	44	76	3.28e-03
GO:BP	GO:0051057	positive regulation of small GTPase mediated signal transduction	34	55	3.34e-03
GO:BP	GO:0002573	myeloid leukocyte differentiation	78	152	3.34e-03
GO:BP	GO:0003179	heart valve morphogenesis	34	55	3.34e-03
GO:BP	GO:0048585	negative regulation of response to stimulus	493	1193	3.36e-03
GO:BP	GO:1905207	regulation of cardiocyte differentiation	17	22	3.42e-03
GO:BP	GO:0042471	ear morphogenesis	43	74	3.43e-03
GO:BP	GO:1902105	regulation of leukocyte differentiation	96	194	3.44e-03
GO:BP	GO:0098660	inorganic ion transmembrane transport	230	521	3.45e-03
GO:BP	GO:0006812	monoatomic cation transport	267	614	3.47e-03
GO:BP	GO:0050680	negative regulation of epithelial cell proliferation	54	98	3.48e-03
GO:BP	GO:1990090	cellular response to nerve growth factor stimulus	27	41	3.56e-03
GO:BP	GO:0055013	cardiac muscle cell development	42	72	3.56e-03
GO:BP	GO:1990089	response to nerve growth factor	27	41	3.56e-03
GO:BP	GO:0010812	negative regulation of cell-substrate adhesion	27	41	3.56e-03
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	721	1791	3.65e-03
GO:BP	GO:0031324	negative regulation of cellular metabolic process	775	1934	3.77e-03
GO:BP	GO:0032409	regulation of transporter activity	76	148	3.81e-03
GO:BP	GO:0022407	regulation of cell-cell adhesion	131	278	3.83e-03
GO:BP	GO:0003015	heart process	100	204	3.83e-03
GO:BP	GO:0046328	regulation of JNK cascade	57	105	3.83e-03
GO:BP	GO:0001704	formation of primary germ layer	52	94	3.93e-03
GO:BP	GO:0003272	endocardial cushion formation	18	24	3.95e-03
GO:BP	GO:0007160	cell-matrix adhesion	85	169	3.95e-03
GO:BP	GO:0051246	regulation of protein metabolic process	646	1595	3.95e-03
GO:BP	GO:0009891	positive regulation of biosynthetic process	745	1856	4.05e-03
GO:BP	GO:0034764	positive regulation of transmembrane transport	68	130	4.06e-03
GO:BP	GO:0035115	embryonic forelimb morphogenesis	14	17	4.09e-03
GO:BP	GO:0048659	smooth muscle cell proliferation	55	101	4.39e-03
GO:BP	GO:1901700	response to oxygen-containing compound	453	1093	4.47e-03
GO:BP	GO:0030177	positive regulation of Wnt signaling pathway	59	110	4.47e-03
GO:BP	GO:0010092	specification of animal organ identity	19	26	4.47e-03
GO:BP	GO:0051962	positive regulation of nervous system development	103	212	4.57e-03
GO:BP	GO:0097435	supramolecular fiber organization	273	633	5.34e-03
GO:BP	GO:0060323	head morphogenesis	21	30	5.36e-03
GO:BP	GO:0048546	digestive tract morphogenesis	21	30	5.36e-03
GO:BP	GO:0150146	cell junction disassembly	15	19	5.39e-03
GO:BP	GO:0003156	regulation of animal organ formation	15	19	5.39e-03
GO:BP	GO:0035137	hindlimb morphogenesis	15	19	5.39e-03
GO:BP	GO:0035136	forelimb morphogenesis	15	19	5.39e-03
GO:BP	GO:0042327	positive regulation of phosphorylation	186	415	5.43e-03
GO:BP	GO:0016331	morphogenesis of embryonic epithelium	64	122	5.45e-03
GO:BP	GO:2000630	positive regulation of miRNA metabolic process	31	50	5.59e-03
GO:BP	GO:0098655	monoatomic cation transmembrane transport	218	495	5.59e-03
GO:BP	GO:0018107	peptidyl-threonine phosphorylation	40	69	5.73e-03
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	46	82	5.73e-03
GO:BP	GO:0003197	endocardial cushion development	29	46	5.84e-03
GO:BP	GO:1902895	positive regulation of miRNA transcription	28	44	5.93e-03
GO:BP	GO:0019827	stem cell population maintenance	73	143	5.95e-03
GO:BP	GO:0010596	negative regulation of endothelial cell migration	25	38	5.95e-03
GO:BP	GO:0048013	ephrin receptor signaling pathway	25	38	5.95e-03
GO:BP	GO:0007632	visual behavior	26	40	5.95e-03
GO:BP	GO:0003151	outflow tract morphogenesis	39	67	5.95e-03
GO:BP	GO:0031290	retinal ganglion cell axon guidance	12	14	5.95e-03
GO:BP	GO:2000725	regulation of cardiac muscle cell differentiation	12	14	5.95e-03
GO:BP	GO:0010634	positive regulation of epithelial cell migration	66	127	6.02e-03
GO:BP	GO:0030856	regulation of epithelial cell differentiation	54	100	6.25e-03
GO:BP	GO:0030282	bone mineralization	44	78	6.42e-03
GO:BP	GO:0014912	negative regulation of smooth muscle cell migration	16	21	6.43e-03
GO:BP	GO:0007492	endoderm development	37	63	6.61e-03
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	132	284	6.86e-03
GO:BP	GO:0010586	miRNA metabolic process	48	87	6.89e-03
GO:BP	GO:0110020	regulation of actomyosin structure organization	48	87	6.89e-03
GO:BP	GO:0022898	regulation of transmembrane transporter activity	71	139	6.89e-03
GO:BP	GO:0018193	peptidyl-amino acid modification	241	555	7.16e-03
GO:BP	GO:0060840	artery development	47	85	7.38e-03
GO:BP	GO:0061337	cardiac conduction	47	85	7.38e-03
GO:BP	GO:0031128	developmental induction	17	23	7.40e-03
GO:BP	GO:0098662	inorganic cation transmembrane transport	211	480	7.52e-03
GO:BP	GO:1901342	regulation of vasculature development	96	198	7.53e-03
GO:BP	GO:0008016	regulation of heart contraction	82	165	7.56e-03
GO:BP	GO:0030099	myeloid cell differentiation	135	292	7.61e-03
GO:BP	GO:2000628	regulation of miRNA metabolic process	41	72	7.62e-03
GO:BP	GO:0048863	stem cell differentiation	93	191	7.66e-03
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	777	1951	7.69e-03
GO:BP	GO:0050769	positive regulation of neurogenesis	90	184	7.80e-03
GO:BP	GO:1905208	negative regulation of cardiocyte differentiation	10	11	7.80e-03
GO:BP	GO:0038180	nerve growth factor signaling pathway	10	11	7.80e-03
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	103	215	7.92e-03
GO:BP	GO:0046777	protein autophosphorylation	72	142	7.98e-03
GO:BP	GO:1903689	regulation of wound healing, spreading of epidermal cells	8	8	7.98e-03
GO:BP	GO:0060993	kidney morphogenesis	39	68	8.53e-03
GO:BP	GO:0060047	heart contraction	94	194	8.66e-03
GO:BP	GO:0018105	peptidyl-serine phosphorylation	80	161	8.69e-03
GO:BP	GO:0001952	regulation of cell-matrix adhesion	49	90	8.69e-03
GO:BP	GO:0010464	regulation of mesenchymal cell proliferation	19	27	8.72e-03
GO:BP	GO:0060325	face morphogenesis	19	27	8.72e-03
GO:BP	GO:0060998	regulation of dendritic spine development	30	49	8.73e-03
GO:BP	GO:0042063	gliogenesis	114	242	8.74e-03
GO:BP	GO:0030278	regulation of ossification	44	79	8.76e-03
GO:BP	GO:0007010	cytoskeleton organization	470	1146	8.83e-03
GO:BP	GO:0001570	vasculogenesis	38	66	8.90e-03
GO:BP	GO:0051017	actin filament bundle assembly	67	131	9.03e-03
GO:BP	GO:0043087	regulation of GTPase activity	82	166	9.17e-03
GO:BP	GO:0007044	cell-substrate junction assembly	48	88	9.17e-03
GO:BP	GO:0048565	digestive tract development	48	88	9.17e-03
GO:BP	GO:0098727	maintenance of cell number	73	145	9.21e-03
GO:BP	GO:0051174	regulation of phosphorus metabolic process	338	805	9.24e-03
GO:BP	GO:0060038	cardiac muscle cell proliferation	27	43	9.39e-03
GO:BP	GO:0006915	apoptotic process	558	1377	9.44e-03
GO:BP	GO:0010171	body morphogenesis	26	41	9.55e-03
GO:BP	GO:0021536	diencephalon development	25	39	9.68e-03
GO:BP	GO:0048511	rhythmic process	105	221	9.69e-03
GO:BP	GO:0008542	visual learning	23	35	9.69e-03
GO:BP	GO:0010594	regulation of endothelial cell migration	69	136	9.76e-03
GO:BP	GO:0010811	positive regulation of cell-substrate adhesion	51	95	9.95e-03
GO:BP	GO:0051234	establishment of localization	1257	3240	1.01e-02
GO:BP	GO:0008219	cell death	575	1423	1.03e-02
GO:BP	GO:0042472	inner ear morphogenesis	35	60	1.03e-02
GO:BP	GO:1902893	regulation of miRNA transcription	35	60	1.03e-02
GO:BP	GO:0071559	response to transforming growth factor beta	104	219	1.03e-02
GO:BP	GO:0060349	bone morphogenesis	41	73	1.04e-02
GO:BP	GO:0070374	positive regulation of ERK1 and ERK2 cascade	58	111	1.04e-02
GO:BP	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	68	134	1.04e-02
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	91	188	1.04e-02
GO:BP	GO:0019220	regulation of phosphate metabolic process	337	804	1.05e-02
GO:BP	GO:0021987	cerebral cortex development	50	93	1.05e-02
GO:BP	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	88	181	1.06e-02
GO:BP	GO:0051147	regulation of muscle cell differentiation	61	118	1.07e-02
GO:BP	GO:0007186	G protein-coupled receptor signaling pathway	172	386	1.10e-02
GO:BP	GO:0001934	positive regulation of protein phosphorylation	176	396	1.10e-02
GO:BP	GO:0061572	actin filament bundle organization	67	132	1.12e-02
GO:BP	GO:0043368	positive T cell selection	15	20	1.18e-02
GO:BP	GO:1903131	mononuclear cell differentiation	128	278	1.18e-02
GO:BP	GO:0022030	telencephalon glial cell migration	15	20	1.18e-02
GO:BP	GO:0099560	synaptic membrane adhesion	15	20	1.18e-02
GO:BP	GO:0021801	cerebral cortex radial glia-guided migration	15	20	1.18e-02
GO:BP	GO:0086065	cell communication involved in cardiac conduction	32	54	1.18e-02
GO:BP	GO:0042475	odontogenesis of dentin-containing tooth	32	54	1.18e-02
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	121	261	1.18e-02
GO:BP	GO:0007398	ectoderm development	11	13	1.19e-02
GO:BP	GO:0031032	actomyosin structure organization	89	184	1.19e-02
GO:BP	GO:0006814	sodium ion transport	69	137	1.20e-02
GO:BP	GO:0002040	sprouting angiogenesis	52	98	1.20e-02
GO:BP	GO:0001837	epithelial to mesenchymal transition	69	137	1.20e-02
GO:BP	GO:0007015	actin filament organization	160	357	1.20e-02
GO:BP	GO:0045669	positive regulation of osteoblast differentiation	31	52	1.22e-02
GO:BP	GO:0003012	muscle system process	147	325	1.22e-02
GO:BP	GO:0048878	chemical homeostasis	284	670	1.23e-02
GO:BP	GO:0061035	regulation of cartilage development	30	50	1.28e-02
GO:BP	GO:0051148	negative regulation of muscle cell differentiation	30	50	1.28e-02
GO:BP	GO:0055123	digestive system development	51	96	1.28e-02
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	68	135	1.28e-02
GO:BP	GO:0003018	vascular process in circulatory system	93	194	1.29e-02
GO:BP	GO:0009890	negative regulation of biosynthetic process	654	1635	1.29e-02
GO:BP	GO:0022409	positive regulation of cell-cell adhesion	85	175	1.29e-02
GO:BP	GO:0003148	outflow tract septum morphogenesis	16	22	1.29e-02
GO:BP	GO:0012501	programmed cell death	572	1419	1.30e-02
GO:BP	GO:0048639	positive regulation of developmental growth	61	119	1.34e-02
GO:BP	GO:0032231	regulation of actin filament bundle assembly	46	85	1.35e-02
GO:BP	GO:0086001	cardiac muscle cell action potential	36	63	1.35e-02
GO:BP	GO:0045446	endothelial cell differentiation	46	85	1.35e-02
GO:BP	GO:0021761	limbic system development	46	85	1.35e-02
GO:BP	GO:0097061	dendritic spine organization	36	63	1.35e-02
GO:BP	GO:0035019	somatic stem cell population maintenance	28	46	1.36e-02
GO:BP	GO:0003407	neural retina development	28	46	1.36e-02
GO:BP	GO:0050954	sensory perception of mechanical stimulus	57	110	1.38e-02
GO:BP	GO:0030516	regulation of axon extension	41	74	1.38e-02
GO:BP	GO:0031644	regulation of nervous system process	41	74	1.38e-02
GO:BP	GO:0017145	stem cell division	17	24	1.38e-02
GO:BP	GO:0086002	cardiac muscle cell action potential involved in contraction	27	44	1.40e-02
GO:BP	GO:0061614	miRNA transcription	35	61	1.42e-02
GO:BP	GO:0060491	regulation of cell projection assembly	78	159	1.43e-02
GO:BP	GO:0042391	regulation of membrane potential	129	282	1.44e-02
GO:BP	GO:0007623	circadian rhythm	75	152	1.44e-02
GO:BP	GO:0086009	membrane repolarization	26	42	1.44e-02
GO:BP	GO:0051336	regulation of hydrolase activity	189	431	1.44e-02
GO:BP	GO:0045058	T cell selection	18	26	1.45e-02
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	649	1624	1.45e-02
GO:BP	GO:0060317	cardiac epithelial to mesenchymal transition	19	28	1.51e-02
GO:BP	GO:0120032	regulation of plasma membrane bounded cell projection assembly	77	157	1.53e-02
GO:BP	GO:0001759	organ induction	12	15	1.53e-02
GO:BP	GO:0038179	neurotrophin signaling pathway	23	36	1.53e-02
GO:BP	GO:0043369	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	12	15	1.53e-02
GO:BP	GO:0001937	negative regulation of endothelial cell proliferation	20	30	1.53e-02
GO:BP	GO:0032330	regulation of chondrocyte differentiation	22	34	1.54e-02
GO:BP	GO:0042325	regulation of phosphorylation	288	683	1.55e-02
GO:BP	GO:0010976	positive regulation of neuron projection development	65	129	1.55e-02
GO:BP	GO:0018209	peptidyl-serine modification	82	169	1.57e-02
GO:BP	GO:0046834	lipid phosphorylation	9	10	1.59e-02
GO:BP	GO:0060572	morphogenesis of an epithelial bud	9	10	1.59e-02
GO:BP	GO:0061458	reproductive system development	97	205	1.61e-02
GO:BP	GO:0048754	branching morphogenesis of an epithelial tube	58	113	1.62e-02
GO:BP	GO:0055085	transmembrane transport	380	921	1.64e-02
GO:BP	GO:0061387	regulation of extent of cell growth	47	88	1.64e-02
GO:BP	GO:0010959	regulation of metal ion transport	111	239	1.64e-02
GO:BP	GO:0007254	JNK cascade	64	127	1.67e-02
GO:BP	GO:0044089	positive regulation of cellular component biogenesis	172	390	1.73e-02
GO:BP	GO:0051492	regulation of stress fiber assembly	42	77	1.74e-02
GO:BP	GO:0048332	mesoderm morphogenesis	31	53	1.74e-02
GO:BP	GO:0045639	positive regulation of myeloid cell differentiation	37	66	1.75e-02
GO:BP	GO:0051153	regulation of striated muscle cell differentiation	37	66	1.75e-02
GO:BP	GO:0001558	regulation of cell growth	145	323	1.77e-02
GO:BP	GO:0043067	regulation of programmed cell death	433	1060	1.79e-02
GO:BP	GO:0042060	wound healing	132	291	1.79e-02
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	634	1588	1.79e-02
GO:BP	GO:0010977	negative regulation of neuron projection development	56	109	1.88e-02
GO:BP	GO:0045765	regulation of angiogenesis	92	194	1.92e-02
GO:BP	GO:0051641	cellular localization	1022	2623	1.95e-02
GO:BP	GO:0001932	regulation of protein phosphorylation	271	642	1.96e-02
GO:BP	GO:0003158	endothelium development	52	100	1.96e-02
GO:BP	GO:0043149	stress fiber assembly	48	91	2.01e-02
GO:BP	GO:0030038	contractile actin filament bundle assembly	48	91	2.01e-02
GO:BP	GO:0045600	positive regulation of fat cell differentiation	28	47	2.02e-02
GO:BP	GO:0030048	actin filament-based movement	55	107	2.02e-02
GO:BP	GO:0090066	regulation of anatomical structure size	167	379	2.08e-02
GO:BP	GO:0002360	T cell lineage commitment	14	19	2.09e-02
GO:BP	GO:0021772	olfactory bulb development	14	19	2.09e-02
GO:BP	GO:0060997	dendritic spine morphogenesis	27	45	2.09e-02
GO:BP	GO:0060512	prostate gland morphogenesis	14	19	2.09e-02
GO:BP	GO:2000647	negative regulation of stem cell proliferation	14	19	2.09e-02
GO:BP	GO:0048566	embryonic digestive tract development	14	19	2.09e-02
GO:BP	GO:0060740	prostate gland epithelium morphogenesis	14	19	2.09e-02
GO:BP	GO:0106027	neuron projection organization	39	71	2.10e-02
GO:BP	GO:0042981	regulation of apoptotic process	421	1031	2.10e-02
GO:BP	GO:0007162	negative regulation of cell adhesion	88	185	2.11e-02
GO:BP	GO:0048608	reproductive structure development	95	202	2.18e-02
GO:BP	GO:0048844	artery morphogenesis	33	58	2.22e-02
GO:BP	GO:0072028	nephron morphogenesis	33	58	2.22e-02
GO:BP	GO:0016192	vesicle-mediated transport	467	1152	2.22e-02
GO:BP	GO:0007605	sensory perception of sound	50	96	2.24e-02
GO:BP	GO:0061383	trabecula morphogenesis	25	41	2.26e-02
GO:BP	GO:0086011	membrane repolarization during action potential	15	21	2.27e-02
GO:BP	GO:0021983	pituitary gland development	15	21	2.27e-02
GO:BP	GO:0070252	actin-mediated cell contraction	46	87	2.29e-02
GO:BP	GO:0050773	regulation of dendrite development	42	78	2.30e-02
GO:BP	GO:0001763	morphogenesis of a branching structure	71	145	2.31e-02
GO:BP	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	10	12	2.31e-02
GO:BP	GO:0045176	apical protein localization	10	12	2.31e-02
GO:BP	GO:0002088	lens development in camera-type eye	32	56	2.31e-02
GO:BP	GO:0045670	regulation of osteoclast differentiation	24	39	2.31e-02
GO:BP	GO:0032486	Rap protein signal transduction	10	12	2.31e-02
GO:BP	GO:0014009	glial cell proliferation	24	39	2.31e-02
GO:BP	GO:0048708	astrocyte differentiation	32	56	2.31e-02
GO:BP	GO:0001658	branching involved in ureteric bud morphogenesis	24	39	2.31e-02
GO:BP	GO:0051491	positive regulation of filopodium assembly	16	23	2.38e-02
GO:BP	GO:0043537	negative regulation of blood vessel endothelial cell migration	16	23	2.38e-02
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	604	1514	2.42e-02
GO:BP	GO:0051963	regulation of synapse assembly	41	76	2.43e-02
GO:BP	GO:0048640	negative regulation of developmental growth	45	85	2.43e-02
GO:BP	GO:0001775	cell activation	264	627	2.51e-02
GO:BP	GO:0030857	negative regulation of epithelial cell differentiation	20	31	2.53e-02
GO:BP	GO:0099622	cardiac muscle cell membrane repolarization	20	31	2.53e-02
GO:BP	GO:0060563	neuroepithelial cell differentiation	19	29	2.53e-02
GO:BP	GO:0006810	transport	1154	2984	2.53e-02
GO:BP	GO:0051050	positive regulation of transport	242	571	2.57e-02
GO:BP	GO:0061180	mammary gland epithelium development	30	52	2.59e-02
GO:BP	GO:0001708	cell fate specification	30	52	2.59e-02
GO:BP	GO:0045927	positive regulation of growth	87	184	2.67e-02
GO:BP	GO:0007043	cell-cell junction assembly	54	106	2.70e-02
GO:BP	GO:0002011	morphogenesis of an epithelial sheet	29	50	2.74e-02
GO:BP	GO:0042490	mechanoreceptor differentiation	29	50	2.74e-02
GO:BP	GO:0030199	collagen fibril organization	29	50	2.74e-02
GO:BP	GO:0006936	muscle contraction	116	255	2.85e-02
GO:BP	GO:0035249	synaptic transmission, glutamatergic	34	61	2.87e-02
GO:BP	GO:0008306	associative learning	34	61	2.87e-02
GO:BP	GO:0001656	metanephros development	34	61	2.87e-02
GO:BP	GO:0060113	inner ear receptor cell differentiation	28	48	2.90e-02
GO:BP	GO:0071772	response to BMP	59	118	2.94e-02
GO:BP	GO:0071773	cellular response to BMP stimulus	59	118	2.94e-02
GO:BP	GO:0048485	sympathetic nervous system development	11	14	2.94e-02
GO:BP	GO:0010842	retina layer formation	11	14	2.94e-02
GO:BP	GO:0002363	alpha-beta T cell lineage commitment	11	14	2.94e-02
GO:BP	GO:0008347	glial cell migration	27	46	3.05e-02
GO:BP	GO:0072171	mesonephric tubule morphogenesis	27	46	3.05e-02
GO:BP	GO:0035725	sodium ion transmembrane transport	49	95	3.05e-02
GO:BP	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	99	214	3.11e-02
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	55	109	3.16e-02
GO:BP	GO:0098657	import into cell	261	622	3.19e-02
GO:BP	GO:0060324	face development	26	44	3.20e-02
GO:BP	GO:0002042	cell migration involved in sprouting angiogenesis	26	44	3.20e-02
GO:BP	GO:0014033	neural crest cell differentiation	41	77	3.22e-02
GO:BP	GO:0007600	sensory perception	114	251	3.23e-02
GO:BP	GO:0021954	central nervous system neuron development	32	57	3.24e-02
GO:BP	GO:0001954	positive regulation of cell-matrix adhesion	25	42	3.36e-02
GO:BP	GO:0060601	lateral sprouting from an epithelium	8	9	3.36e-02
GO:BP	GO:1901329	regulation of odontoblast differentiation	8	9	3.36e-02
GO:BP	GO:0045986	negative regulation of smooth muscle contraction	8	9	3.36e-02
GO:BP	GO:0008361	regulation of cell size	71	147	3.37e-02
GO:BP	GO:0006935	chemotaxis	111	244	3.39e-02
GO:BP	GO:0007498	mesoderm development	44	84	3.39e-02
GO:BP	GO:0042330	taxis	111	244	3.39e-02
GO:BP	GO:0055008	cardiac muscle tissue morphogenesis	31	55	3.44e-02
GO:BP	GO:0045668	negative regulation of osteoblast differentiation	23	38	3.68e-02
GO:BP	GO:0061001	regulation of dendritic spine morphogenesis	22	36	3.84e-02
GO:BP	GO:0003203	endocardial cushion morphogenesis	22	36	3.84e-02
GO:BP	GO:0048704	embryonic skeletal system morphogenesis	29	51	3.94e-02
GO:BP	GO:0001707	mesoderm formation	29	51	3.94e-02
GO:BP	GO:0051591	response to cAMP	34	62	3.95e-02
GO:BP	GO:0050865	regulation of cell activation	152	347	3.96e-02
GO:BP	GO:0030509	BMP signaling pathway	55	110	3.96e-02
GO:BP	GO:0007159	leukocyte cell-cell adhesion	100	218	3.96e-02
GO:BP	GO:0010629	negative regulation of gene expression	325	790	4.01e-02
GO:BP	GO:0045926	negative regulation of growth	86	184	4.02e-02
GO:BP	GO:0002053	positive regulation of mesenchymal cell proliferation	14	20	4.04e-02
GO:BP	GO:0021516	dorsal spinal cord development	6	6	4.04e-02
GO:BP	GO:0048617	embryonic foregut morphogenesis	6	6	4.04e-02
GO:BP	GO:1901289	succinyl-CoA catabolic process	6	6	4.04e-02
GO:BP	GO:0072178	nephric duct morphogenesis	6	6	4.04e-02
GO:BP	GO:0050861	positive regulation of B cell receptor signaling pathway	6	6	4.04e-02
GO:BP	GO:0021814	cell motility involved in cerebral cortex radial glia guided migration	6	6	4.04e-02
GO:BP	GO:0050982	detection of mechanical stimulus	20	32	4.05e-02
GO:BP	GO:0008154	actin polymerization or depolymerization	71	148	4.05e-02
GO:BP	GO:0032233	positive regulation of actin filament bundle assembly	28	49	4.13e-02
GO:BP	GO:0060914	heart formation	19	30	4.15e-02
GO:BP	GO:0033688	regulation of osteoblast proliferation	15	22	4.16e-02
GO:BP	GO:0048661	positive regulation of smooth muscle cell proliferation	33	60	4.16e-02
GO:BP	GO:0021675	nerve development	33	60	4.16e-02
GO:BP	GO:1902107	positive regulation of leukocyte differentiation	57	115	4.17e-02
GO:BP	GO:1903708	positive regulation of hemopoiesis	57	115	4.17e-02
GO:BP	GO:0072006	nephron development	57	115	4.17e-02
GO:BP	GO:0030510	regulation of BMP signaling pathway	41	78	4.17e-02
GO:BP	GO:0021799	cerebral cortex radially oriented cell migration	17	26	4.18e-02
GO:BP	GO:0071392	cellular response to estradiol stimulus	16	24	4.18e-02
GO:BP	GO:0048048	embryonic eye morphogenesis	16	24	4.18e-02
GO:BP	GO:0003181	atrioventricular valve morphogenesis	17	26	4.18e-02
GO:BP	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	16	24	4.18e-02
GO:BP	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	17	26	4.18e-02
GO:BP	GO:0110110	positive regulation of animal organ morphogenesis	17	26	4.18e-02
GO:BP	GO:0035282	segmentation	37	69	4.18e-02
GO:BP	GO:0033687	osteoblast proliferation	17	26	4.18e-02
GO:BP	GO:0010721	negative regulation of cell development	85	182	4.19e-02
GO:BP	GO:0033135	regulation of peptidyl-serine phosphorylation	44	85	4.30e-02
GO:BP	GO:0050790	regulation of catalytic activity	364	893	4.37e-02
GO:BP	GO:0061333	renal tubule morphogenesis	32	58	4.38e-02
GO:BP	GO:0008543	fibroblast growth factor receptor signaling pathway	32	58	4.38e-02
GO:BP	GO:0071805	potassium ion transmembrane transport	59	120	4.38e-02
GO:BP	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	56	113	4.43e-02
GO:BP	GO:0055001	muscle cell development	77	163	4.43e-02
GO:BP	GO:0060675	ureteric bud morphogenesis	26	45	4.56e-02
GO:BP	GO:0035331	negative regulation of hippo signaling	9	11	4.61e-02
GO:BP	GO:0021895	cerebral cortex neuron differentiation	9	11	4.61e-02
GO:BP	GO:0090263	positive regulation of canonical Wnt signaling pathway	43	83	4.62e-02
GO:BP	GO:0072088	nephron epithelium morphogenesis	31	56	4.67e-02
GO:BP	GO:0003229	ventricular cardiac muscle tissue development	31	56	4.67e-02
GO:BP	GO:0046928	regulation of neurotransmitter secretion	31	56	4.67e-02
GO:BP	GO:0002682	regulation of immune system process	354	868	4.70e-02
GO:BP	GO:0110053	regulation of actin filament organization	97	212	4.70e-02
GO:BP	GO:0061326	renal tubule development	39	74	4.75e-02
GO:BP	GO:0048864	stem cell development	39	74	4.75e-02
GO:BP	GO:0030316	osteoclast differentiation	35	65	4.78e-02
GO:BP	GO:0051496	positive regulation of stress fiber assembly	25	43	4.78e-02
GO:BP	GO:0009880	embryonic pattern specification	25	43	4.78e-02
GO:BP	GO:0050679	positive regulation of epithelial cell proliferation	68	142	4.93e-02
GO:BP	GO:0019722	calcium-mediated signaling	60	123	4.97e-02
GO:BP	GO:0072078	nephron tubule morphogenesis	30	54	4.97e-02

EARnomtable %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in EAR neargenes") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in EAR neargenes

source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:04510	Focal adhesion	97	169	6.03e-06
KEGG	KEGG:04015	Rap1 signaling pathway	90	162	7.47e-05
KEGG	KEGG:04360	Axon guidance	84	155	4.62e-04
KEGG	KEGG:04512	ECM-receptor interaction	42	66	5.12e-04
KEGG	KEGG:04520	Adherens junction	49	83	1.45e-03
KEGG	KEGG:04310	Wnt signaling pathway	71	133	2.44e-03
KEGG	KEGG:04024	cAMP signaling pathway	75	147	6.33e-03
KEGG	KEGG:04010	MAPK signaling pathway	111	231	6.33e-03
KEGG	KEGG:04726	Serotonergic synapse	35	58	6.33e-03
KEGG	KEGG:05200	Pathways in cancer	177	391	6.33e-03
KEGG	KEGG:05222	Small cell lung cancer	46	82	6.46e-03
KEGG	KEGG:04151	PI3K-Akt signaling pathway	118	250	7.19e-03
KEGG	KEGG:04014	Ras signaling pathway	81	164	9.91e-03
KEGG	KEGG:05202	Transcriptional misregulation in cancer	63	122	9.91e-03
KEGG	KEGG:05412	Arrhythmogenic right ventricular cardiomyopathy	38	67	1.24e-02
KEGG	KEGG:04350	TGF-beta signaling pathway	48	90	1.47e-02
KEGG	KEGG:04810	Regulation of actin cytoskeleton	82	169	1.47e-02
KEGG	KEGG:05205	Proteoglycans in cancer	79	162	1.47e-02
KEGG	KEGG:04514	Cell adhesion molecules	38	69	2.10e-02
KEGG	KEGG:04730	Long-term depression	24	39	2.10e-02
KEGG	KEGG:04390	Hippo signaling pathway	64	129	2.22e-02
KEGG	KEGG:04713	Circadian entrainment	37	68	2.80e-02
KEGG	KEGG:04928	Parathyroid hormone synthesis, secretion and action	41	78	3.73e-02
KEGG	KEGG:04068	FoxO signaling pathway	53	106	3.91e-02
KEGG	KEGG:04974	Protein digestion and absorption	31	56	3.97e-02
KEGG	KEGG:04072	Phospholipase D signaling pathway	53	107	4.66e-02

ESR response genes

# ESR_resgenes <- gost(query = ESR_NG_list$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(ESR_resgenes,"data/GO_KEGG_analysis/ESR_resgenes.RDS")

ESRnom <- gostplot(ESR_resgenes, capped = FALSE, interactive = TRUE)
# ESRnom

ESRnomtable <- ESR_resgenes$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

ESRnomtable %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in ESR neargenes" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in ESR neargenes

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0032501	multicellular organismal process	2719	4504	6.19e-51
GO:BP	GO:0048856	anatomical structure development	2368	3867	1.05e-48
GO:BP	GO:0009653	anatomical structure morphogenesis	1237	1844	1.90e-47
GO:BP	GO:0032502	developmental process	2521	4179	2.35e-45
GO:BP	GO:0007275	multicellular organism development	1971	3170	2.02e-44
GO:BP	GO:0007154	cell communication	2411	3983	2.68e-44
GO:BP	GO:0023052	signaling	2374	3918	7.47e-44
GO:BP	GO:0048731	system development	1713	2719	3.79e-42
GO:BP	GO:0007165	signal transduction	2187	3611	9.13e-39
GO:BP	GO:0030154	cell differentiation	1746	2803	1.06e-38
GO:BP	GO:0048869	cellular developmental process	1746	2804	1.33e-38
GO:BP	GO:0050896	response to stimulus	3104	5379	5.22e-35
GO:BP	GO:0051716	cellular response to stimulus	2717	4640	6.46e-35
GO:BP	GO:0051239	regulation of multicellular organismal process	1237	1924	5.46e-34
GO:BP	GO:0009888	tissue development	904	1348	2.90e-33
GO:BP	GO:0048513	animal organ development	1279	2004	3.55e-33
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	597	837	4.28e-32
GO:BP	GO:0007399	nervous system development	1136	1775	1.60e-29
GO:BP	GO:0007155	cell adhesion	651	941	7.22e-29
GO:BP	GO:0010646	regulation of cell communication	1503	2444	4.76e-28
GO:BP	GO:0007166	cell surface receptor signaling pathway	1142	1801	2.61e-27
GO:BP	GO:0023051	regulation of signaling	1496	2438	3.01e-27
GO:BP	GO:0035295	tube development	553	787	7.25e-27
GO:BP	GO:0072359	circulatory system development	599	864	8.41e-27
GO:BP	GO:0016477	cell migration	686	1011	9.57e-27
GO:BP	GO:0048468	cell development	1184	1886	5.73e-26
GO:BP	GO:0050793	regulation of developmental process	1076	1697	1.61e-25
GO:BP	GO:0048870	cell motility	745	1120	2.94e-25
GO:BP	GO:0035239	tube morphogenesis	458	638	3.31e-25
GO:BP	GO:0022008	neurogenesis	819	1251	9.61e-25
GO:BP	GO:0003008	system process	752	1139	4.38e-24
GO:BP	GO:0048729	tissue morphogenesis	340	453	6.87e-24
GO:BP	GO:0009887	animal organ morphogenesis	475	673	1.46e-23
GO:BP	GO:0051240	positive regulation of multicellular organismal process	692	1040	2.24e-23
GO:BP	GO:0048699	generation of neurons	711	1076	8.28e-23
GO:BP	GO:2000026	regulation of multicellular organismal development	637	951	1.83e-22
GO:BP	GO:0030182	neuron differentiation	671	1014	1.21e-21
GO:BP	GO:0141124	intracellular signaling cassette	842	1314	2.89e-21
GO:BP	GO:0007267	cell-cell signaling	709	1082	2.91e-21
GO:BP	GO:0009966	regulation of signal transduction	1316	2166	6.52e-21
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	493	717	1.33e-20
GO:BP	GO:0051094	positive regulation of developmental process	607	913	3.88e-20
GO:BP	GO:0030334	regulation of cell migration	461	668	1.15e-19
GO:BP	GO:0001944	vasculature development	391	552	1.24e-19
GO:BP	GO:0050789	regulation of biological process	4101	7516	3.07e-19
GO:BP	GO:0040011	locomotion	540	805	5.25e-19
GO:BP	GO:0048583	regulation of response to stimulus	1605	2717	7.46e-19
GO:BP	GO:2000145	regulation of cell motility	477	700	1.07e-18
GO:BP	GO:0001568	blood vessel development	372	525	1.07e-18
GO:BP	GO:0044057	regulation of system process	285	384	1.07e-18
GO:BP	GO:0065007	biological regulation	4205	7734	1.75e-18
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	422	609	1.86e-18
GO:BP	GO:0040012	regulation of locomotion	488	720	1.89e-18
GO:BP	GO:0060429	epithelium development	530	792	2.43e-18
GO:BP	GO:0034330	cell junction organization	383	545	2.60e-18
GO:BP	GO:0098609	cell-cell adhesion	394	564	3.80e-18
GO:BP	GO:0050794	regulation of cellular process	3906	7153	1.53e-17
GO:BP	GO:0048514	blood vessel morphogenesis	323	450	1.64e-17
GO:BP	GO:0030029	actin filament-based process	437	640	2.59e-17
GO:BP	GO:0002009	morphogenesis of an epithelium	272	369	3.69e-17
GO:BP	GO:0000902	cell morphogenesis	478	713	1.18e-16
GO:BP	GO:0009790	embryo development	541	821	1.22e-16
GO:BP	GO:0071495	cellular response to endogenous stimulus	664	1035	1.36e-16
GO:BP	GO:0035556	intracellular signal transduction	1175	1951	1.58e-16
GO:BP	GO:0045595	regulation of cell differentiation	685	1073	1.95e-16
GO:BP	GO:0045597	positive regulation of cell differentiation	405	591	2.08e-16
GO:BP	GO:0032989	cellular anatomical entity morphogenesis	403	588	2.42e-16
GO:BP	GO:0003013	circulatory system process	305	426	2.87e-16
GO:BP	GO:0048518	positive regulation of biological process	2429	4301	3.13e-16
GO:BP	GO:0060485	mesenchyme development	191	245	3.48e-16
GO:BP	GO:0048519	negative regulation of biological process	2146	3764	3.74e-16
GO:BP	GO:0048522	positive regulation of cellular process	2246	3954	3.89e-16
GO:BP	GO:0048598	embryonic morphogenesis	302	422	4.42e-16
GO:BP	GO:0030155	regulation of cell adhesion	354	508	5.26e-16
GO:BP	GO:0048523	negative regulation of cellular process	2030	3550	9.49e-16
GO:BP	GO:0070848	response to growth factor	376	547	1.55e-15
GO:BP	GO:0007507	heart development	347	499	1.86e-15
GO:BP	GO:0051128	regulation of cellular component organization	1120	1862	1.96e-15
GO:BP	GO:0008015	blood circulation	260	357	2.56e-15
GO:BP	GO:0065008	regulation of biological quality	1136	1893	2.94e-15
GO:BP	GO:0009719	response to endogenous stimulus	749	1197	4.69e-15
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	722	1150	6.09e-15
GO:BP	GO:0048666	neuron development	544	838	7.15e-15
GO:BP	GO:0061061	muscle structure development	367	536	9.31e-15
GO:BP	GO:0030030	cell projection organization	739	1182	1.01e-14
GO:BP	GO:0071363	cellular response to growth factor stimulus	362	528	1.09e-14
GO:BP	GO:0031175	neuron projection development	488	743	1.35e-14
GO:BP	GO:0014706	striated muscle tissue development	167	213	1.47e-14
GO:BP	GO:0048762	mesenchymal cell differentiation	158	200	2.74e-14
GO:BP	GO:0048738	cardiac muscle tissue development	158	201	6.30e-14
GO:BP	GO:0030036	actin cytoskeleton organization	382	566	6.89e-14
GO:BP	GO:0042127	regulation of cell population proliferation	676	1077	6.96e-14
GO:BP	GO:0001525	angiogenesis	271	381	7.21e-14
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	338	494	1.76e-13
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	315	456	2.20e-13
GO:BP	GO:0048858	cell projection morphogenesis	340	498	2.30e-13
GO:BP	GO:0008285	negative regulation of cell population proliferation	322	469	3.95e-13
GO:BP	GO:0051241	negative regulation of multicellular organismal process	460	706	7.81e-13
GO:BP	GO:0060562	epithelial tube morphogenesis	194	261	9.34e-13
GO:BP	GO:0010647	positive regulation of cell communication	749	1218	1.35e-12
GO:BP	GO:0023057	negative regulation of signaling	647	1036	1.35e-12
GO:BP	GO:0007423	sensory organ development	271	387	1.52e-12
GO:BP	GO:0023056	positive regulation of signaling	750	1221	1.80e-12
GO:BP	GO:0007010	cytoskeleton organization	708	1146	1.89e-12
GO:BP	GO:0051049	regulation of transport	681	1098	1.98e-12
GO:BP	GO:0008283	cell population proliferation	797	1306	1.99e-12
GO:BP	GO:0010648	negative regulation of cell communication	645	1034	2.00e-12
GO:BP	GO:0048812	neuron projection morphogenesis	325	479	3.29e-12
GO:BP	GO:0003012	muscle system process	232	325	4.33e-12
GO:BP	GO:0060537	muscle tissue development	240	339	6.98e-12
GO:BP	GO:0001667	ameboidal-type cell migration	243	344	7.18e-12
GO:BP	GO:0051093	negative regulation of developmental process	407	622	1.06e-11
GO:BP	GO:0042221	response to chemical	1336	2304	1.47e-11
GO:BP	GO:0006468	protein phosphorylation	598	958	1.59e-11
GO:BP	GO:0034329	cell junction assembly	229	323	1.99e-11
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	296	435	2.60e-11
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	337	505	3.26e-11
GO:BP	GO:0098657	import into cell	405	622	3.52e-11
GO:BP	GO:0007417	central nervous system development	446	694	4.58e-11
GO:BP	GO:0048589	developmental growth	334	501	4.96e-11
GO:BP	GO:0072001	renal system development	179	244	6.49e-11
GO:BP	GO:0010720	positive regulation of cell development	219	309	6.74e-11
GO:BP	GO:0031344	regulation of cell projection organization	342	516	8.22e-11
GO:BP	GO:0048568	embryonic organ development	215	303	8.93e-11
GO:BP	GO:0048585	negative regulation of response to stimulus	725	1193	1.10e-10
GO:BP	GO:1902531	regulation of intracellular signal transduction	777	1289	1.75e-10
GO:BP	GO:0051960	regulation of nervous system development	236	339	1.76e-10
GO:BP	GO:0060322	head development	354	539	1.98e-10
GO:BP	GO:0072073	kidney epithelium development	92	111	2.23e-10
GO:BP	GO:0030001	metal ion transport	345	524	2.32e-10
GO:BP	GO:0009968	negative regulation of signal transduction	600	972	2.48e-10
GO:BP	GO:0009967	positive regulation of signal transduction	667	1093	3.12e-10
GO:BP	GO:0001501	skeletal system development	240	347	3.22e-10
GO:BP	GO:0003007	heart morphogenesis	161	218	3.42e-10
GO:BP	GO:0003206	cardiac chamber morphogenesis	91	110	3.49e-10
GO:BP	GO:0044087	regulation of cellular component biogenesis	478	757	3.61e-10
GO:BP	GO:0045165	cell fate commitment	118	151	4.59e-10
GO:BP	GO:0003205	cardiac chamber development	118	151	4.59e-10
GO:BP	GO:0090596	sensory organ morphogenesis	132	173	5.78e-10
GO:BP	GO:0007420	brain development	328	498	7.15e-10
GO:BP	GO:0001822	kidney development	172	237	7.36e-10
GO:BP	GO:0032879	regulation of localization	855	1439	9.26e-10
GO:BP	GO:0034762	regulation of transmembrane transport	209	298	9.79e-10
GO:BP	GO:0007186	G protein-coupled receptor signaling pathway	261	386	1.63e-09
GO:BP	GO:0001823	mesonephros development	65	74	1.79e-09
GO:BP	GO:0006936	muscle contraction	182	255	1.94e-09
GO:BP	GO:1903522	regulation of blood circulation	144	194	2.29e-09
GO:BP	GO:0003231	cardiac ventricle development	93	115	2.36e-09
GO:BP	GO:0010975	regulation of neuron projection development	242	355	2.45e-09
GO:BP	GO:0045596	negative regulation of cell differentiation	299	452	2.74e-09
GO:BP	GO:0072164	mesonephric tubule development	64	73	2.95e-09
GO:BP	GO:0072163	mesonephric epithelium development	64	73	2.95e-09
GO:BP	GO:0060284	regulation of cell development	367	570	3.33e-09
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	177	248	3.47e-09
GO:BP	GO:0030335	positive regulation of cell migration	265	395	3.86e-09
GO:BP	GO:0016310	phosphorylation	689	1145	4.94e-09
GO:BP	GO:0001657	ureteric bud development	63	72	4.94e-09
GO:BP	GO:0016043	cellular component organization	2629	4802	5.18e-09
GO:BP	GO:0051179	localization	2071	3731	5.58e-09
GO:BP	GO:0030900	forebrain development	191	272	5.75e-09
GO:BP	GO:2000147	positive regulation of cell motility	272	408	5.80e-09
GO:BP	GO:0007264	small GTPase-mediated signal transduction	261	390	7.69e-09
GO:BP	GO:0090257	regulation of muscle system process	132	177	8.05e-09
GO:BP	GO:0045785	positive regulation of cell adhesion	208	301	8.37e-09
GO:BP	GO:0140352	export from cell	379	594	8.42e-09
GO:BP	GO:0060560	developmental growth involved in morphogenesis	140	190	9.34e-09
GO:BP	GO:0003151	outflow tract morphogenesis	59	67	1.06e-08
GO:BP	GO:0060411	cardiac septum morphogenesis	59	67	1.06e-08
GO:BP	GO:0007409	axonogenesis	229	337	1.18e-08
GO:BP	GO:0061448	connective tissue development	149	205	1.27e-08
GO:BP	GO:0043269	regulation of monoatomic ion transport	196	282	1.27e-08
GO:BP	GO:0001837	epithelial to mesenchymal transition	106	137	1.32e-08
GO:BP	GO:0044093	positive regulation of molecular function	485	783	1.39e-08
GO:BP	GO:0060047	heart contraction	142	194	1.46e-08
GO:BP	GO:0051216	cartilage development	111	145	1.55e-08
GO:BP	GO:0040017	positive regulation of locomotion	275	416	1.62e-08
GO:BP	GO:0030855	epithelial cell differentiation	282	428	1.62e-08
GO:BP	GO:0048880	sensory system development	186	266	1.62e-08
GO:BP	GO:0042692	muscle cell differentiation	220	323	1.82e-08
GO:BP	GO:0099177	regulation of trans-synaptic signaling	220	323	1.82e-08
GO:BP	GO:0061564	axon development	249	372	1.82e-08
GO:BP	GO:0001654	eye development	184	263	1.84e-08
GO:BP	GO:0006810	transport	1673	2984	1.89e-08
GO:BP	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	90	113	1.89e-08
GO:BP	GO:0070887	cellular response to chemical stimulus	1015	1751	2.12e-08
GO:BP	GO:0050808	synapse organization	228	337	2.23e-08
GO:BP	GO:0035265	organ growth	99	127	2.28e-08
GO:BP	GO:0099537	trans-synaptic signaling	304	467	2.31e-08
GO:BP	GO:0050804	modulation of chemical synaptic transmission	219	322	2.36e-08
GO:BP	GO:0009792	embryo development ending in birth or egg hatching	335	521	2.49e-08
GO:BP	GO:0009893	positive regulation of metabolic process	1480	2622	2.65e-08
GO:BP	GO:0002062	chondrocyte differentiation	73	88	2.66e-08
GO:BP	GO:0150063	visual system development	184	264	2.85e-08
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	165	233	3.35e-08
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	301	463	3.37e-08
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	301	463	3.37e-08
GO:BP	GO:0010810	regulation of cell-substrate adhesion	121	162	3.39e-08
GO:BP	GO:0003018	vascular process in circulatory system	141	194	3.39e-08
GO:BP	GO:0065009	regulation of molecular function	768	1299	3.42e-08
GO:BP	GO:0048863	stem cell differentiation	139	191	3.84e-08
GO:BP	GO:0003015	heart process	147	204	3.96e-08
GO:BP	GO:0060419	heart growth	61	71	4.05e-08
GO:BP	GO:0198738	cell-cell signaling by wnt	240	359	4.09e-08
GO:BP	GO:1901888	regulation of cell junction assembly	117	156	4.09e-08
GO:BP	GO:0040007	growth	434	697	4.15e-08
GO:BP	GO:0048584	positive regulation of response to stimulus	879	1504	4.15e-08
GO:BP	GO:0050767	regulation of neurogenesis	199	290	4.29e-08
GO:BP	GO:0097485	neuron projection guidance	127	172	4.29e-08
GO:BP	GO:0007411	axon guidance	127	172	4.29e-08
GO:BP	GO:0003279	cardiac septum development	82	102	4.35e-08
GO:BP	GO:0099536	synaptic signaling	312	483	4.35e-08
GO:BP	GO:0090130	tissue migration	173	247	4.71e-08
GO:BP	GO:0043062	extracellular structure organization	159	224	4.73e-08
GO:BP	GO:0045229	external encapsulating structure organization	159	224	4.73e-08
GO:BP	GO:0001775	cell activation	394	627	4.92e-08
GO:BP	GO:0016055	Wnt signaling pathway	239	358	5.11e-08
GO:BP	GO:0010959	regulation of metal ion transport	168	239	5.22e-08
GO:BP	GO:0046903	secretion	391	622	5.28e-08
GO:BP	GO:0007268	chemical synaptic transmission	300	463	5.48e-08
GO:BP	GO:0098916	anterograde trans-synaptic signaling	300	463	5.48e-08
GO:BP	GO:0071310	cellular response to organic substance	765	1297	6.20e-08
GO:BP	GO:0045216	cell-cell junction organization	114	152	6.21e-08
GO:BP	GO:0008284	positive regulation of cell population proliferation	381	605	6.21e-08
GO:BP	GO:0030198	extracellular matrix organization	158	223	6.36e-08
GO:BP	GO:0043009	chordate embryonic development	325	507	6.45e-08
GO:BP	GO:0010243	response to organonitrogen compound	426	685	6.91e-08
GO:BP	GO:0040013	negative regulation of locomotion	170	243	7.05e-08
GO:BP	GO:0090132	epithelium migration	170	243	7.05e-08
GO:BP	GO:0010631	epithelial cell migration	170	243	7.05e-08
GO:BP	GO:0043410	positive regulation of MAPK cascade	197	288	7.18e-08
GO:BP	GO:0031589	cell-substrate adhesion	179	258	7.25e-08
GO:BP	GO:0008016	regulation of heart contraction	122	165	7.25e-08
GO:BP	GO:0006897	endocytosis	316	492	7.78e-08
GO:BP	GO:0072006	nephron development	90	115	8.05e-08
GO:BP	GO:0010033	response to organic substance	1002	1736	8.14e-08
GO:BP	GO:0031401	positive regulation of protein modification process	349	550	8.55e-08
GO:BP	GO:0097435	supramolecular fiber organization	396	633	9.09e-08
GO:BP	GO:0006816	calcium ion transport	181	262	9.74e-08
GO:BP	GO:0051146	striated muscle cell differentiation	164	234	1.07e-07
GO:BP	GO:0006811	monoatomic ion transport	444	719	1.11e-07
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	1364	2415	1.12e-07
GO:BP	GO:0003208	cardiac ventricle morphogenesis	54	62	1.14e-07
GO:BP	GO:0022407	regulation of cell-cell adhesion	190	278	1.48e-07
GO:BP	GO:0016331	morphogenesis of embryonic epithelium	94	122	1.48e-07
GO:BP	GO:0043010	camera-type eye development	161	230	1.68e-07
GO:BP	GO:0050877	nervous system process	376	600	1.71e-07
GO:BP	GO:0051962	positive regulation of nervous system development	150	212	1.77e-07
GO:BP	GO:0051130	positive regulation of cellular component organization	516	850	1.79e-07
GO:BP	GO:0006915	apoptotic process	805	1377	1.93e-07
GO:BP	GO:0060348	bone development	109	146	2.00e-07
GO:BP	GO:0035148	tube formation	95	124	2.01e-07
GO:BP	GO:0010632	regulation of epithelial cell migration	135	188	2.28e-07
GO:BP	GO:0061035	regulation of cartilage development	45	50	2.39e-07
GO:BP	GO:0071417	cellular response to organonitrogen compound	285	442	2.61e-07
GO:BP	GO:0050673	epithelial cell proliferation	202	300	3.06e-07
GO:BP	GO:0032940	secretion by cell	347	551	3.08e-07
GO:BP	GO:0043408	regulation of MAPK cascade	276	427	3.18e-07
GO:BP	GO:1901698	response to nitrogen compound	451	736	3.30e-07
GO:BP	GO:0070588	calcium ion transmembrane transport	148	210	3.30e-07
GO:BP	GO:0051234	establishment of localization	1795	3240	3.40e-07
GO:BP	GO:0008219	cell death	828	1423	3.56e-07
GO:BP	GO:0031399	regulation of protein modification process	548	911	3.60e-07
GO:BP	GO:0034220	monoatomic ion transmembrane transport	367	587	3.67e-07
GO:BP	GO:0033002	muscle cell proliferation	112	152	4.19e-07
GO:BP	GO:0012501	programmed cell death	825	1419	4.62e-07
GO:BP	GO:0023061	signal release	210	315	5.25e-07
GO:BP	GO:1901700	response to oxygen-containing compound	647	1093	5.44e-07
GO:BP	GO:0009605	response to external stimulus	900	1559	5.67e-07
GO:BP	GO:0061138	morphogenesis of a branching epithelium	101	135	5.72e-07
GO:BP	GO:0071773	cellular response to BMP stimulus	90	118	7.05e-07
GO:BP	GO:0071772	response to BMP	90	118	7.05e-07
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	147	210	7.29e-07
GO:BP	GO:0031325	positive regulation of cellular metabolic process	1313	2333	7.32e-07
GO:BP	GO:0001763	morphogenesis of a branching structure	107	145	7.56e-07
GO:BP	GO:0006937	regulation of muscle contraction	95	126	7.75e-07
GO:BP	GO:0098660	inorganic ion transmembrane transport	328	521	7.90e-07
GO:BP	GO:0061326	renal tubule development	61	74	8.38e-07
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	191	284	8.38e-07
GO:BP	GO:0051046	regulation of secretion	256	396	1.02e-06
GO:BP	GO:0072175	epithelial tube formation	89	117	1.03e-06
GO:BP	GO:0055017	cardiac muscle tissue growth	54	64	1.10e-06
GO:BP	GO:0001503	ossification	201	302	1.24e-06
GO:BP	GO:1901342	regulation of vasculature development	139	198	1.29e-06
GO:BP	GO:0045664	regulation of neuron differentiation	97	130	1.33e-06
GO:BP	GO:0010717	regulation of epithelial to mesenchymal transition	68	85	1.35e-06
GO:BP	GO:0007159	leukocyte cell-cell adhesion	151	218	1.36e-06
GO:BP	GO:0007162	negative regulation of cell adhesion	131	185	1.38e-06
GO:BP	GO:0060038	cardiac muscle cell proliferation	39	43	1.41e-06
GO:BP	GO:0030336	negative regulation of cell migration	146	210	1.55e-06
GO:BP	GO:0007610	behavior	269	420	1.57e-06
GO:BP	GO:0048562	embryonic organ morphogenesis	129	182	1.58e-06
GO:BP	GO:0042472	inner ear morphogenesis	51	60	1.58e-06
GO:BP	GO:0009611	response to wounding	247	382	1.68e-06
GO:BP	GO:0035051	cardiocyte differentiation	98	132	1.68e-06
GO:BP	GO:0007369	gastrulation	103	140	1.69e-06
GO:BP	GO:0007389	pattern specification process	191	286	1.78e-06
GO:BP	GO:2000146	negative regulation of cell motility	150	217	1.79e-06
GO:BP	GO:0050769	positive regulation of neurogenesis	130	184	1.86e-06
GO:BP	GO:1901701	cellular response to oxygen-containing compound	480	796	1.86e-06
GO:BP	GO:0055085	transmembrane transport	549	921	1.86e-06
GO:BP	GO:0030048	actin filament-based movement	82	107	1.90e-06
GO:BP	GO:0006935	chemotaxis	166	244	1.95e-06
GO:BP	GO:0042330	taxis	166	244	1.95e-06
GO:BP	GO:0003281	ventricular septum development	57	69	1.95e-06
GO:BP	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	61	75	2.05e-06
GO:BP	GO:0030510	regulation of BMP signaling pathway	63	78	2.05e-06
GO:BP	GO:0045321	leukocyte activation	331	530	2.06e-06
GO:BP	GO:0046777	protein autophosphorylation	104	142	2.07e-06
GO:BP	GO:0043085	positive regulation of catalytic activity	340	546	2.08e-06
GO:BP	GO:0006796	phosphate-containing compound metabolic process	1069	1883	2.08e-06
GO:BP	GO:0003229	ventricular cardiac muscle tissue development	48	56	2.17e-06
GO:BP	GO:0007015	actin filament organization	232	357	2.19e-06
GO:BP	GO:0044089	positive regulation of cellular component biogenesis	251	390	2.24e-06
GO:BP	GO:0006812	monoatomic cation transport	378	614	2.31e-06
GO:BP	GO:2000027	regulation of animal organ morphogenesis	50	59	2.45e-06
GO:BP	GO:0150115	cell-substrate junction organization	74	95	2.46e-06
GO:BP	GO:0051174	regulation of phosphorus metabolic process	484	805	2.62e-06
GO:BP	GO:0042327	positive regulation of phosphorylation	265	415	2.69e-06
GO:BP	GO:0098662	inorganic cation transmembrane transport	302	480	2.78e-06
GO:BP	GO:0007517	muscle organ development	179	267	2.87e-06
GO:BP	GO:0048839	inner ear development	98	133	2.92e-06
GO:BP	GO:0060993	kidney morphogenesis	56	68	2.99e-06
GO:BP	GO:0048645	animal organ formation	45	52	2.99e-06
GO:BP	GO:0051247	positive regulation of protein metabolic process	542	911	3.04e-06
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	145	210	3.05e-06
GO:BP	GO:0019220	regulation of phosphate metabolic process	483	804	3.05e-06
GO:BP	GO:0014033	neural crest cell differentiation	62	77	3.06e-06
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	433	714	3.17e-06
GO:BP	GO:0051050	positive regulation of transport	353	571	3.29e-06
GO:BP	GO:0043583	ear development	109	151	3.37e-06
GO:BP	GO:0055008	cardiac muscle tissue morphogenesis	47	55	3.45e-06
GO:BP	GO:0098655	monoatomic cation transmembrane transport	310	495	3.46e-06
GO:BP	GO:0006793	phosphorus metabolic process	1078	1904	3.53e-06
GO:BP	GO:0001704	formation of primary germ layer	73	94	3.59e-06
GO:BP	GO:0042592	homeostatic process	665	1137	3.62e-06
GO:BP	GO:0030111	regulation of Wnt signaling pathway	175	261	3.77e-06
GO:BP	GO:0072028	nephron morphogenesis	49	58	3.81e-06
GO:BP	GO:0061333	renal tubule morphogenesis	49	58	3.81e-06
GO:BP	GO:0048844	artery morphogenesis	49	58	3.81e-06
GO:BP	GO:0045765	regulation of angiogenesis	135	194	3.94e-06
GO:BP	GO:0007044	cell-substrate junction assembly	69	88	3.99e-06
GO:BP	GO:0051924	regulation of calcium ion transport	110	153	4.04e-06
GO:BP	GO:0060415	muscle tissue morphogenesis	51	61	4.12e-06
GO:BP	GO:0061337	cardiac conduction	67	85	4.17e-06
GO:BP	GO:0048644	muscle organ morphogenesis	53	64	4.37e-06
GO:BP	GO:0072080	nephron tubule development	57	70	4.61e-06
GO:BP	GO:0042391	regulation of membrane potential	187	282	4.61e-06
GO:BP	GO:0030509	BMP signaling pathway	83	110	4.62e-06
GO:BP	GO:0071840	cellular component organization or biogenesis	2690	4988	5.01e-06
GO:BP	GO:0022612	gland morphogenesis	72	93	5.24e-06
GO:BP	GO:1901699	cellular response to nitrogen compound	300	479	5.24e-06
GO:BP	GO:0042060	wound healing	192	291	5.39e-06
GO:BP	GO:0048167	regulation of synaptic plasticity	101	139	5.46e-06
GO:BP	GO:0001952	regulation of cell-matrix adhesion	70	90	5.56e-06
GO:BP	GO:0000165	MAPK cascade	314	504	5.56e-06
GO:BP	GO:0022409	positive regulation of cell-cell adhesion	123	175	5.72e-06
GO:BP	GO:0070252	actin-mediated cell contraction	68	87	5.90e-06
GO:BP	GO:0060070	canonical Wnt signaling pathway	163	242	6.11e-06
GO:BP	GO:0072009	nephron epithelium development	66	84	6.22e-06
GO:BP	GO:0014070	response to organic cyclic compound	371	606	6.31e-06
GO:BP	GO:0060412	ventricular septum morphogenesis	36	40	6.35e-06
GO:BP	GO:0060421	positive regulation of heart growth	27	28	6.52e-06
GO:BP	GO:0001932	regulation of protein phosphorylation	391	642	6.52e-06
GO:BP	GO:0009987	cellular process	5561	10686	6.84e-06
GO:BP	GO:0021915	neural tube development	97	133	6.88e-06
GO:BP	GO:0090288	negative regulation of cellular response to growth factor stimulus	60	75	6.88e-06
GO:BP	GO:0006941	striated muscle contraction	105	146	7.11e-06
GO:BP	GO:0001838	embryonic epithelial tube formation	80	106	7.20e-06
GO:BP	GO:0031214	biomineral tissue development	80	106	7.20e-06
GO:BP	GO:0018212	peptidyl-tyrosine modification	116	164	7.20e-06
GO:BP	GO:0051336	regulation of hydrolase activity	272	431	7.29e-06
GO:BP	GO:0001934	positive regulation of protein phosphorylation	252	396	7.41e-06
GO:BP	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	67	86	8.72e-06
GO:BP	GO:0050803	regulation of synapse structure or activity	123	176	9.02e-06
GO:BP	GO:0072088	nephron epithelium morphogenesis	47	56	9.52e-06
GO:BP	GO:0060048	cardiac muscle contraction	86	116	9.88e-06
GO:BP	GO:0050807	regulation of synapse organization	121	173	1.04e-05
GO:BP	GO:0002521	leukocyte differentiation	237	371	1.07e-05
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	130	188	1.07e-05
GO:BP	GO:0032970	regulation of actin filament-based process	196	300	1.09e-05
GO:BP	GO:1903530	regulation of secretion by cell	234	366	1.14e-05
GO:BP	GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	172	259	1.15e-05
GO:BP	GO:0009628	response to abiotic stimulus	483	811	1.16e-05
GO:BP	GO:0035108	limb morphogenesis	82	110	1.22e-05
GO:BP	GO:0035107	appendage morphogenesis	82	110	1.22e-05
GO:BP	GO:0060420	regulation of heart growth	42	49	1.23e-05
GO:BP	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	108	152	1.24e-05
GO:BP	GO:0060045	positive regulation of cardiac muscle cell proliferation	22	22	1.24e-05
GO:BP	GO:0003148	outflow tract septum morphogenesis	22	22	1.24e-05
GO:BP	GO:0009612	response to mechanical stimulus	108	152	1.24e-05
GO:BP	GO:0060840	artery development	66	85	1.28e-05
GO:BP	GO:0042325	regulation of phosphorylation	412	683	1.28e-05
GO:BP	GO:0018108	peptidyl-tyrosine phosphorylation	114	162	1.32e-05
GO:BP	GO:0060043	regulation of cardiac muscle cell proliferation	29	31	1.32e-05
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	64	82	1.35e-05
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	1222	2186	1.35e-05
GO:BP	GO:1903037	regulation of leukocyte cell-cell adhesion	135	197	1.39e-05
GO:BP	GO:0003179	heart valve morphogenesis	46	55	1.49e-05
GO:BP	GO:0060395	SMAD protein signal transduction	60	76	1.50e-05
GO:BP	GO:0098771	inorganic ion homeostasis	223	348	1.58e-05
GO:BP	GO:0007160	cell-matrix adhesion	118	169	1.58e-05
GO:BP	GO:0048588	developmental cell growth	124	179	1.61e-05
GO:BP	GO:0055074	calcium ion homeostasis	146	216	1.71e-05
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	81	109	1.72e-05
GO:BP	GO:0007498	mesoderm development	65	84	1.90e-05
GO:BP	GO:0032409	regulation of transporter activity	105	148	1.92e-05
GO:BP	GO:0097553	calcium ion transmembrane import into cytosol	89	122	1.92e-05
GO:BP	GO:0050806	positive regulation of synaptic transmission	79	106	1.92e-05
GO:BP	GO:0110110	positive regulation of animal organ morphogenesis	25	26	2.07e-05
GO:BP	GO:0043270	positive regulation of monoatomic ion transport	92	127	2.10e-05
GO:BP	GO:0032330	regulation of chondrocyte differentiation	31	34	2.12e-05
GO:BP	GO:0003161	cardiac conduction system development	31	34	2.12e-05
GO:BP	GO:0050678	regulation of epithelial cell proliferation	165	249	2.25e-05
GO:BP	GO:0090066	regulation of anatomical structure size	240	379	2.29e-05
GO:BP	GO:1905314	semi-lunar valve development	36	41	2.29e-05
GO:BP	GO:0035924	cellular response to vascular endothelial growth factor stimulus	45	54	2.33e-05
GO:BP	GO:0072078	nephron tubule morphogenesis	45	54	2.33e-05
GO:BP	GO:0014910	regulation of smooth muscle cell migration	45	54	2.33e-05
GO:BP	GO:0010817	regulation of hormone levels	205	318	2.33e-05
GO:BP	GO:0048660	regulation of smooth muscle cell proliferation	73	97	2.61e-05
GO:BP	GO:0048732	gland development	199	308	2.64e-05
GO:BP	GO:0006874	intracellular calcium ion homeostasis	137	202	2.70e-05
GO:BP	GO:0046879	hormone secretion	137	202	2.70e-05
GO:BP	GO:0048771	tissue remodeling	83	113	2.73e-05
GO:BP	GO:0048754	branching morphogenesis of an epithelial tube	83	113	2.73e-05
GO:BP	GO:0055010	ventricular cardiac muscle tissue morphogenesis	38	44	2.74e-05
GO:BP	GO:0022898	regulation of transmembrane transporter activity	99	139	2.85e-05
GO:BP	GO:0031346	positive regulation of cell projection organization	186	286	3.07e-05
GO:BP	GO:0048041	focal adhesion assembly	60	77	3.18e-05
GO:BP	GO:0050865	regulation of cell activation	221	347	3.25e-05
GO:BP	GO:0099003	vesicle-mediated transport in synapse	117	169	3.29e-05
GO:BP	GO:0001649	osteoblast differentiation	120	174	3.29e-05
GO:BP	GO:0015833	peptide transport	123	179	3.29e-05
GO:BP	GO:0031644	regulation of nervous system process	58	74	3.33e-05
GO:BP	GO:0048864	stem cell development	58	74	3.33e-05
GO:BP	GO:0042471	ear morphogenesis	58	74	3.33e-05
GO:BP	GO:0046649	lymphocyte activation	276	444	3.36e-05
GO:BP	GO:0048592	eye morphogenesis	79	107	3.41e-05
GO:BP	GO:0055023	positive regulation of cardiac muscle tissue growth	24	25	3.65e-05
GO:BP	GO:0003170	heart valve development	52	65	3.77e-05
GO:BP	GO:0043087	regulation of GTPase activity	115	166	3.77e-05
GO:BP	GO:0035296	regulation of tube diameter	75	101	4.29e-05
GO:BP	GO:0007163	establishment or maintenance of cell polarity	125	183	4.29e-05
GO:BP	GO:0035150	regulation of tube size	75	101	4.29e-05
GO:BP	GO:0097746	blood vessel diameter maintenance	75	101	4.29e-05
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	96	135	4.45e-05
GO:BP	GO:0006813	potassium ion transport	96	135	4.45e-05
GO:BP	GO:0003002	regionalization	169	258	4.65e-05
GO:BP	GO:0010634	positive regulation of epithelial cell migration	91	127	4.83e-05
GO:BP	GO:0050878	regulation of body fluid levels	152	229	4.83e-05
GO:BP	GO:0009914	hormone transport	139	207	5.02e-05
GO:BP	GO:0072171	mesonephric tubule morphogenesis	39	46	5.02e-05
GO:BP	GO:0048878	chemical homeostasis	401	670	5.04e-05
GO:BP	GO:0048638	regulation of developmental growth	160	243	5.41e-05
GO:BP	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	143	214	5.43e-05
GO:BP	GO:0071407	cellular response to organic cyclic compound	238	379	5.89e-05
GO:BP	GO:0072091	regulation of stem cell proliferation	49	61	5.89e-05
GO:BP	GO:0009891	positive regulation of biosynthetic process	1040	1856	6.19e-05
GO:BP	GO:0030097	hemopoiesis	375	624	6.22e-05
GO:BP	GO:0060078	regulation of postsynaptic membrane potential	60	78	6.44e-05
GO:BP	GO:0031032	actomyosin structure organization	125	184	6.44e-05
GO:BP	GO:0003272	endocardial cushion formation	23	24	6.53e-05
GO:BP	GO:0051345	positive regulation of hydrolase activity	173	266	6.68e-05
GO:BP	GO:0010628	positive regulation of gene expression	442	746	6.76e-05
GO:BP	GO:0048736	appendage development	96	136	7.25e-05
GO:BP	GO:0060173	limb development	96	136	7.25e-05
GO:BP	GO:0014812	muscle cell migration	56	72	7.43e-05
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	1031	1841	7.75e-05
GO:BP	GO:0003184	pulmonary valve morphogenesis	19	19	7.75e-05
GO:BP	GO:0014032	neural crest cell development	54	69	7.88e-05
GO:BP	GO:0006939	smooth muscle contraction	54	69	7.88e-05
GO:BP	GO:0060675	ureteric bud morphogenesis	38	45	8.03e-05
GO:BP	GO:1902107	positive regulation of leukocyte differentiation	83	115	8.09e-05
GO:BP	GO:1903708	positive regulation of hemopoiesis	83	115	8.09e-05
GO:BP	GO:0042110	T cell activation	195	305	8.59e-05
GO:BP	GO:0010718	positive regulation of epithelial to mesenchymal transition	40	48	8.60e-05
GO:BP	GO:0021953	central nervous system neuron differentiation	73	99	8.60e-05
GO:BP	GO:0071805	potassium ion transmembrane transport	86	120	8.61e-05
GO:BP	GO:0055001	muscle cell development	112	163	8.88e-05
GO:BP	GO:0001707	mesoderm formation	42	51	8.89e-05
GO:BP	GO:0014909	smooth muscle cell migration	48	60	8.89e-05
GO:BP	GO:0072132	mesenchyme morphogenesis	42	51	8.89e-05
GO:BP	GO:0045666	positive regulation of neuron differentiation	46	57	9.01e-05
GO:BP	GO:0043067	regulation of programmed cell death	612	1060	9.15e-05
GO:BP	GO:0070372	regulation of ERK1 and ERK2 cascade	119	175	9.88e-05
GO:BP	GO:0006949	syncytium formation	33	38	1.00e-04
GO:BP	GO:0031345	negative regulation of cell projection organization	101	145	1.01e-04
GO:BP	GO:0050790	regulation of catalytic activity	521	893	1.02e-04
GO:BP	GO:0008544	epidermis development	139	209	1.04e-04
GO:BP	GO:0008150	biological_process	5821	11244	1.13e-04
GO:BP	GO:0061036	positive regulation of cartilage development	22	23	1.15e-04
GO:BP	GO:0002063	chondrocyte development	22	23	1.15e-04
GO:BP	GO:0070371	ERK1 and ERK2 cascade	130	194	1.16e-04
GO:BP	GO:0060541	respiratory system development	111	162	1.17e-04
GO:BP	GO:0048639	positive regulation of developmental growth	85	119	1.18e-04
GO:BP	GO:0045667	regulation of osteoblast differentiation	72	98	1.21e-04
GO:BP	GO:0030010	establishment of cell polarity	88	124	1.24e-04
GO:BP	GO:0055021	regulation of cardiac muscle tissue growth	37	44	1.27e-04
GO:BP	GO:0060976	coronary vasculature development	37	44	1.27e-04
GO:BP	GO:0042981	regulation of apoptotic process	595	1031	1.31e-04
GO:BP	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	94	134	1.31e-04
GO:BP	GO:0046883	regulation of hormone secretion	112	164	1.33e-04
GO:BP	GO:0014855	striated muscle cell proliferation	47	59	1.34e-04
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	135	203	1.39e-04
GO:BP	GO:0048332	mesoderm morphogenesis	43	53	1.39e-04
GO:BP	GO:0051249	regulation of lymphocyte activation	179	279	1.47e-04
GO:BP	GO:0003158	endothelium development	73	100	1.50e-04
GO:BP	GO:0002790	peptide secretion	113	166	1.52e-04
GO:BP	GO:0010594	regulation of endothelial cell migration	95	136	1.54e-04
GO:BP	GO:1903039	positive regulation of leukocyte cell-cell adhesion	101	146	1.57e-04
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	1001	1791	1.61e-04
GO:BP	GO:0003176	aortic valve development	32	37	1.63e-04
GO:BP	GO:0055007	cardiac muscle cell differentiation	76	105	1.63e-04
GO:BP	GO:0050708	regulation of protein secretion	120	178	1.64e-04
GO:BP	GO:0021537	telencephalon development	130	195	1.66e-04
GO:BP	GO:0019722	calcium-mediated signaling	87	123	1.67e-04
GO:BP	GO:0030513	positive regulation of BMP signaling pathway	27	30	1.72e-04
GO:BP	GO:0048705	skeletal system morphogenesis	102	148	1.81e-04
GO:BP	GO:0002694	regulation of leukocyte activation	198	313	1.85e-04
GO:BP	GO:0050770	regulation of axonogenesis	88	125	2.00e-04
GO:BP	GO:0048663	neuron fate commitment	24	26	2.04e-04
GO:BP	GO:0010092	specification of animal organ identity	24	26	2.04e-04
GO:BP	GO:0003177	pulmonary valve development	21	22	2.04e-04
GO:BP	GO:0050870	positive regulation of T cell activation	94	135	2.07e-04
GO:BP	GO:0051893	regulation of focal adhesion assembly	44	55	2.09e-04
GO:BP	GO:0003197	endocardial cushion development	38	46	2.09e-04
GO:BP	GO:0090109	regulation of cell-substrate junction assembly	44	55	2.09e-04
GO:BP	GO:0060390	regulation of SMAD protein signal transduction	40	49	2.13e-04
GO:BP	GO:1902105	regulation of leukocyte differentiation	129	194	2.14e-04
GO:BP	GO:0071692	protein localization to extracellular region	165	256	2.18e-04
GO:BP	GO:2000648	positive regulation of stem cell proliferation	29	33	2.21e-04
GO:BP	GO:0003180	aortic valve morphogenesis	29	33	2.21e-04
GO:BP	GO:0061572	actin filament bundle organization	92	132	2.37e-04
GO:BP	GO:0002573	myeloid leukocyte differentiation	104	152	2.37e-04
GO:BP	GO:0070482	response to oxygen levels	170	265	2.39e-04
GO:BP	GO:0048565	digestive tract development	65	88	2.39e-04
GO:BP	GO:0001935	endothelial cell proliferation	81	114	2.51e-04
GO:BP	GO:0036211	protein modification process	1263	2291	2.54e-04
GO:BP	GO:0048659	smooth muscle cell proliferation	73	101	2.55e-04
GO:BP	GO:0060445	branching involved in salivary gland morphogenesis	17	17	2.58e-04
GO:BP	GO:0061351	neural precursor cell proliferation	84	119	2.60e-04
GO:BP	GO:0140253	cell-cell fusion	31	36	2.61e-04
GO:BP	GO:0038084	vascular endothelial growth factor signaling pathway	31	36	2.61e-04
GO:BP	GO:0000768	syncytium formation by plasma membrane fusion	31	36	2.61e-04
GO:BP	GO:0010463	mesenchymal cell proliferation	31	36	2.61e-04
GO:BP	GO:0045446	endothelial cell differentiation	63	85	2.66e-04
GO:BP	GO:0007492	endoderm development	49	63	2.68e-04
GO:BP	GO:0007043	cell-cell junction assembly	76	106	2.70e-04
GO:BP	GO:1990138	neuron projection extension	93	134	2.72e-04
GO:BP	GO:0150116	regulation of cell-substrate junction organization	47	60	2.85e-04
GO:BP	GO:1902893	regulation of miRNA transcription	47	60	2.85e-04
GO:BP	GO:0002040	sprouting angiogenesis	71	98	2.87e-04
GO:BP	GO:0001658	branching involved in ureteric bud morphogenesis	33	39	2.90e-04
GO:BP	GO:0071774	response to fibroblast growth factor	61	82	2.96e-04
GO:BP	GO:0051283	negative regulation of sequestering of calcium ion	66	90	2.96e-04
GO:BP	GO:0071559	response to transforming growth factor beta	143	219	2.97e-04
GO:BP	GO:1903131	mononuclear cell differentiation	177	278	2.97e-04
GO:BP	GO:0006954	inflammatory response	260	425	3.08e-04
GO:BP	GO:0032835	glomerulus development	43	54	3.11e-04
GO:BP	GO:0086065	cell communication involved in cardiac conduction	43	54	3.11e-04
GO:BP	GO:0051017	actin filament bundle assembly	91	131	3.11e-04
GO:BP	GO:1903169	regulation of calcium ion transmembrane transport	77	108	3.23e-04
GO:BP	GO:0042476	odontogenesis	59	79	3.27e-04
GO:BP	GO:0044344	cellular response to fibroblast growth factor stimulus	59	79	3.27e-04
GO:BP	GO:0048593	camera-type eye morphogenesis	64	87	3.30e-04
GO:BP	GO:0014020	primary neural tube formation	64	87	3.30e-04
GO:BP	GO:0030326	embryonic limb morphogenesis	64	87	3.30e-04
GO:BP	GO:0035113	embryonic appendage morphogenesis	64	87	3.30e-04
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	167	261	3.35e-04
GO:BP	GO:0050863	regulation of T cell activation	134	204	3.45e-04
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	263	431	3.51e-04
GO:BP	GO:0002064	epithelial cell development	101	148	3.51e-04
GO:BP	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	95	138	3.58e-04
GO:BP	GO:0001841	neural tube formation	67	92	3.63e-04
GO:BP	GO:0010721	negative regulation of cell development	121	182	3.74e-04
GO:BP	GO:0060349	bone morphogenesis	55	73	4.03e-04
GO:BP	GO:0051209	release of sequestered calcium ion into cytosol	65	89	4.13e-04
GO:BP	GO:0006942	regulation of striated muscle contraction	60	81	4.16e-04
GO:BP	GO:0045860	positive regulation of protein kinase activity	122	184	4.16e-04
GO:BP	GO:0046622	positive regulation of organ growth	30	35	4.16e-04
GO:BP	GO:0030072	peptide hormone secretion	109	162	4.32e-04
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	140	215	4.32e-04
GO:BP	GO:0045444	fat cell differentiation	119	179	4.33e-04
GO:BP	GO:0098659	inorganic cation import across plasma membrane	53	70	4.40e-04
GO:BP	GO:0016049	cell growth	235	382	4.40e-04
GO:BP	GO:0099565	chemical synaptic transmission, postsynaptic	53	70	4.40e-04
GO:BP	GO:0099587	inorganic ion import across plasma membrane	53	70	4.40e-04
GO:BP	GO:0043616	keratinocyte proliferation	32	38	4.56e-04
GO:BP	GO:0099173	postsynapse organization	100	147	4.61e-04
GO:BP	GO:0050679	positive regulation of epithelial cell proliferation	97	142	4.69e-04
GO:BP	GO:2000463	positive regulation of excitatory postsynaptic potential	25	28	4.70e-04
GO:BP	GO:0098739	import across plasma membrane	85	122	4.70e-04
GO:BP	GO:0030073	insulin secretion	94	137	4.72e-04
GO:BP	GO:0098815	modulation of excitatory postsynaptic potential	34	41	4.78e-04
GO:BP	GO:1905330	regulation of morphogenesis of an epithelium	34	41	4.78e-04
GO:BP	GO:0048010	vascular endothelial growth factor receptor signaling pathway	40	50	4.78e-04
GO:BP	GO:0034332	adherens junction organization	36	44	4.89e-04
GO:BP	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	66	91	5.02e-04
GO:BP	GO:0034767	positive regulation of monoatomic ion transmembrane transport	66	91	5.02e-04
GO:BP	GO:0009306	protein secretion	161	252	5.06e-04
GO:BP	GO:0035592	establishment of protein localization to extracellular region	161	252	5.06e-04
GO:BP	GO:0086003	cardiac muscle cell contraction	49	64	5.24e-04
GO:BP	GO:0016358	dendrite development	121	183	5.26e-04
GO:BP	GO:0030324	lung development	98	144	5.28e-04
GO:BP	GO:0055123	digestive system development	69	96	5.36e-04
GO:BP	GO:0061614	miRNA transcription	47	61	5.69e-04
GO:BP	GO:0042063	gliogenesis	155	242	5.80e-04
GO:BP	GO:0051251	positive regulation of lymphocyte activation	122	185	5.82e-04
GO:BP	GO:0030098	lymphocyte differentiation	159	249	5.83e-04
GO:BP	GO:0042886	amide transport	133	204	6.02e-04
GO:BP	GO:0043069	negative regulation of programmed cell death	378	642	6.10e-04
GO:BP	GO:0016192	vesicle-mediated transport	654	1152	6.14e-04
GO:BP	GO:1904018	positive regulation of vasculature development	81	116	6.18e-04
GO:BP	GO:0007416	synapse assembly	93	136	6.18e-04
GO:BP	GO:0051051	negative regulation of transport	180	286	6.18e-04
GO:BP	GO:0051235	maintenance of location	160	251	6.25e-04
GO:BP	GO:0032526	response to retinoic acid	57	77	6.51e-04
GO:BP	GO:0001666	response to hypoxia	149	232	6.58e-04
GO:BP	GO:0006898	receptor-mediated endocytosis	120	182	6.71e-04
GO:BP	GO:0030323	respiratory tube development	100	148	6.76e-04
GO:BP	GO:0001708	cell fate specification	41	52	6.91e-04
GO:BP	GO:0001570	vasculogenesis	50	66	6.93e-04
GO:BP	GO:0050796	regulation of insulin secretion	79	113	7.12e-04
GO:BP	GO:0050920	regulation of chemotaxis	91	133	7.15e-04
GO:BP	GO:0030100	regulation of endocytosis	128	196	7.32e-04
GO:BP	GO:0071526	semaphorin-plexin signaling pathway	35	43	7.54e-04
GO:BP	GO:0036293	response to decreased oxygen levels	155	243	7.73e-04
GO:BP	GO:0050801	monoatomic ion homeostasis	247	406	7.73e-04
GO:BP	GO:0007215	glutamate receptor signaling pathway	24	27	7.79e-04
GO:BP	GO:0032870	cellular response to hormone stimulus	262	433	7.82e-04
GO:BP	GO:0043542	endothelial cell migration	115	174	8.14e-04
GO:BP	GO:0006836	neurotransmitter transport	92	135	8.15e-04
GO:BP	GO:0002761	regulation of myeloid leukocyte differentiation	58	79	8.16e-04
GO:BP	GO:0071375	cellular response to peptide hormone stimulus	148	231	8.16e-04
GO:BP	GO:0009410	response to xenobiotic stimulus	172	273	8.17e-04
GO:BP	GO:0034764	positive regulation of transmembrane transport	89	130	8.22e-04
GO:BP	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	86	125	8.28e-04
GO:BP	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	66	92	8.36e-04
GO:BP	GO:0051282	regulation of sequestering of calcium ion	66	92	8.36e-04
GO:BP	GO:0001759	organ induction	15	15	8.36e-04
GO:BP	GO:0022604	regulation of cell morphogenesis	126	193	8.37e-04
GO:BP	GO:0010001	glial cell differentiation	119	181	8.45e-04
GO:BP	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	119	181	8.45e-04
GO:BP	GO:0060606	tube closure	61	84	8.84e-04
GO:BP	GO:0035270	endocrine system development	61	84	8.84e-04
GO:BP	GO:0010876	lipid localization	186	298	8.84e-04
GO:BP	GO:0043434	response to peptide hormone	195	314	8.99e-04
GO:BP	GO:0051129	negative regulation of cellular component organization	329	555	9.01e-04
GO:BP	GO:0051963	regulation of synapse assembly	56	76	9.06e-04
GO:BP	GO:1901890	positive regulation of cell junction assembly	56	76	9.06e-04
GO:BP	GO:0060914	heart formation	26	30	9.27e-04
GO:BP	GO:0002791	regulation of peptide secretion	90	132	9.27e-04
GO:BP	GO:0042475	odontogenesis of dentin-containing tooth	42	54	9.55e-04
GO:BP	GO:0055117	regulation of cardiac muscle contraction	49	65	9.86e-04
GO:BP	GO:0060079	excitatory postsynaptic potential	49	65	9.86e-04
GO:BP	GO:0033674	positive regulation of kinase activity	128	197	9.95e-04
GO:BP	GO:0051047	positive regulation of secretion	132	204	1.02e-03
GO:BP	GO:0030031	cell projection assembly	269	447	1.03e-03
GO:BP	GO:1901652	response to peptide	225	368	1.03e-03
GO:BP	GO:0032924	activin receptor signaling pathway	28	33	1.04e-03
GO:BP	GO:0003156	regulation of animal organ formation	18	19	1.06e-03
GO:BP	GO:0001764	neuron migration	88	129	1.07e-03
GO:BP	GO:0001755	neural crest cell migration	38	48	1.07e-03
GO:BP	GO:0051058	negative regulation of small GTPase mediated signal transduction	38	48	1.07e-03
GO:BP	GO:0140115	export across plasma membrane	38	48	1.07e-03
GO:BP	GO:0051961	negative regulation of nervous system development	76	109	1.08e-03
GO:BP	GO:0070167	regulation of biomineral tissue development	47	62	1.08e-03
GO:BP	GO:0099504	synaptic vesicle cycle	101	151	1.08e-03
GO:BP	GO:0045766	positive regulation of angiogenesis	79	114	1.08e-03
GO:BP	GO:0003203	endocardial cushion morphogenesis	30	36	1.10e-03
GO:BP	GO:0002376	immune system process	789	1410	1.12e-03
GO:BP	GO:0046632	alpha-beta T cell differentiation	52	70	1.13e-03
GO:BP	GO:0046620	regulation of organ growth	52	70	1.13e-03
GO:BP	GO:0040008	regulation of growth	277	462	1.13e-03
GO:BP	GO:0060627	regulation of vesicle-mediated transport	228	374	1.17e-03
GO:BP	GO:0001936	regulation of endothelial cell proliferation	68	96	1.18e-03
GO:BP	GO:0055080	monoatomic cation homeostasis	243	401	1.19e-03
GO:BP	GO:0120031	plasma membrane bounded cell projection assembly	263	437	1.19e-03
GO:BP	GO:0051641	cellular localization	1428	2623	1.19e-03
GO:BP	GO:0007611	learning or memory	123	189	1.20e-03
GO:BP	GO:0001843	neural tube closure	60	83	1.20e-03
GO:BP	GO:0002027	regulation of heart rate	60	83	1.20e-03
GO:BP	GO:0070374	positive regulation of ERK1 and ERK2 cascade	77	111	1.24e-03
GO:BP	GO:0043066	negative regulation of apoptotic process	363	619	1.24e-03
GO:BP	GO:2000181	negative regulation of blood vessel morphogenesis	50	67	1.25e-03
GO:BP	GO:0051588	regulation of neurotransmitter transport	50	67	1.25e-03
GO:BP	GO:1901343	negative regulation of vasculature development	50	67	1.25e-03
GO:BP	GO:0014896	muscle hypertrophy	55	75	1.25e-03
GO:BP	GO:0050867	positive regulation of cell activation	131	203	1.25e-03
GO:BP	GO:0045927	positive regulation of growth	120	184	1.26e-03
GO:BP	GO:0046928	regulation of neurotransmitter secretion	43	56	1.27e-03
GO:BP	GO:2000628	regulation of miRNA metabolic process	53	72	1.42e-03
GO:BP	GO:0014902	myotube differentiation	61	85	1.47e-03
GO:BP	GO:1902414	protein localization to cell junction	61	85	1.47e-03
GO:BP	GO:0060563	neuroepithelial cell differentiation	25	29	1.48e-03
GO:BP	GO:0007520	myoblast fusion	25	29	1.48e-03
GO:BP	GO:0090497	mesenchymal cell migration	39	50	1.49e-03
GO:BP	GO:0023019	signal transduction involved in regulation of gene expression	14	14	1.50e-03
GO:BP	GO:0009991	response to extracellular stimulus	229	377	1.51e-03
GO:BP	GO:0090276	regulation of peptide hormone secretion	88	130	1.57e-03
GO:BP	GO:0046888	negative regulation of hormone secretion	37	47	1.58e-03
GO:BP	GO:0031667	response to nutrient levels	216	354	1.61e-03
GO:BP	GO:1905207	regulation of cardiocyte differentiation	20	22	1.61e-03
GO:BP	GO:0048333	mesodermal cell differentiation	20	22	1.61e-03
GO:BP	GO:1903779	regulation of cardiac conduction	20	22	1.61e-03
GO:BP	GO:1902284	neuron projection extension involved in neuron projection guidance	27	32	1.63e-03
GO:BP	GO:0048846	axon extension involved in axon guidance	27	32	1.63e-03
GO:BP	GO:0086002	cardiac muscle cell action potential involved in contraction	35	44	1.66e-03
GO:BP	GO:0002696	positive regulation of leukocyte activation	127	197	1.67e-03
GO:BP	GO:0032414	positive regulation of ion transmembrane transporter activity	44	58	1.70e-03
GO:BP	GO:0010812	negative regulation of cell-substrate adhesion	33	41	1.71e-03
GO:BP	GO:0006814	sodium ion transport	92	137	1.71e-03
GO:BP	GO:0048168	regulation of neuronal synaptic plasticity	31	38	1.72e-03
GO:BP	GO:0048013	ephrin receptor signaling pathway	31	38	1.72e-03
GO:BP	GO:0000082	G1/S transition of mitotic cell cycle	120	185	1.72e-03
GO:BP	GO:0007613	memory	62	87	1.74e-03
GO:BP	GO:0014897	striated muscle hypertrophy	54	74	1.74e-03
GO:BP	GO:0016525	negative regulation of angiogenesis	49	66	1.76e-03
GO:BP	GO:0018105	peptidyl-serine phosphorylation	106	161	1.78e-03
GO:BP	GO:0001816	cytokine production	264	441	1.82e-03
GO:BP	GO:0031099	regeneration	96	144	1.83e-03
GO:BP	GO:0050890	cognition	136	213	1.83e-03
GO:BP	GO:0007009	plasma membrane organization	74	107	1.89e-03
GO:BP	GO:1903706	regulation of hemopoiesis	161	257	1.91e-03
GO:BP	GO:0043535	regulation of blood vessel endothelial cell migration	52	71	1.97e-03
GO:BP	GO:0090087	regulation of peptide transport	90	134	1.97e-03
GO:BP	GO:0072089	stem cell proliferation	60	84	1.99e-03
GO:BP	GO:0043500	muscle adaptation	63	89	2.08e-03
GO:BP	GO:0010595	positive regulation of endothelial cell migration	63	89	2.08e-03
GO:BP	GO:0051246	regulation of protein metabolic process	884	1595	2.08e-03
GO:BP	GO:0006470	protein dephosphorylation	115	177	2.11e-03
GO:BP	GO:0006869	lipid transport	163	261	2.16e-03
GO:BP	GO:0007266	Rho protein signal transduction	75	109	2.18e-03
GO:BP	GO:0045685	regulation of glial cell differentiation	38	49	2.18e-03
GO:BP	GO:1903053	regulation of extracellular matrix organization	38	49	2.18e-03
GO:BP	GO:0099175	regulation of postsynapse organization	58	81	2.28e-03
GO:BP	GO:1904064	positive regulation of cation transmembrane transport	58	81	2.28e-03
GO:BP	GO:0060350	endochondral bone morphogenesis	36	46	2.34e-03
GO:BP	GO:0097120	receptor localization to synapse	36	46	2.34e-03
GO:BP	GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway	24	28	2.38e-03
GO:BP	GO:0001817	regulation of cytokine production	261	437	2.39e-03
GO:BP	GO:0009952	anterior/posterior pattern specification	82	121	2.41e-03
GO:BP	GO:0003300	cardiac muscle hypertrophy	53	73	2.43e-03
GO:BP	GO:0051208	sequestering of calcium ion	67	96	2.49e-03
GO:BP	GO:0048813	dendrite morphogenesis	76	111	2.49e-03
GO:BP	GO:0035023	regulation of Rho protein signal transduction	48	65	2.50e-03
GO:BP	GO:0010644	cell communication by electrical coupling	26	31	2.56e-03
GO:BP	GO:0071634	regulation of transforming growth factor beta production	26	31	2.56e-03
GO:BP	GO:0050900	leukocyte migration	125	195	2.57e-03
GO:BP	GO:0018209	peptidyl-serine modification	110	169	2.57e-03
GO:BP	GO:0050795	regulation of behavior	32	40	2.58e-03
GO:BP	GO:0055006	cardiac cell development	56	78	2.58e-03
GO:BP	GO:0071868	cellular response to monoamine stimulus	28	34	2.64e-03
GO:BP	GO:0071870	cellular response to catecholamine stimulus	28	34	2.64e-03
GO:BP	GO:0061037	negative regulation of cartilage development	19	21	2.68e-03
GO:BP	GO:0014912	negative regulation of smooth muscle cell migration	19	21	2.68e-03
GO:BP	GO:0046631	alpha-beta T cell activation	62	88	2.81e-03
GO:BP	GO:0043547	positive regulation of GTPase activity	77	113	2.83e-03
GO:BP	GO:0045598	regulation of fat cell differentiation	65	93	2.86e-03
GO:BP	GO:0050680	negative regulation of epithelial cell proliferation	68	98	2.89e-03
GO:BP	GO:0050768	negative regulation of neurogenesis	71	103	2.89e-03
GO:BP	GO:0033993	response to lipid	335	573	2.91e-03
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	689	1231	2.92e-03
GO:BP	GO:0019935	cyclic-nucleotide-mediated signaling	39	51	2.93e-03
GO:BP	GO:1901653	cellular response to peptide	169	273	3.01e-03
GO:BP	GO:0009725	response to hormone	355	610	3.06e-03
GO:BP	GO:0140747	regulation of ncRNA transcription	57	80	3.10e-03
GO:BP	GO:2001257	regulation of cation channel activity	49	67	3.10e-03
GO:BP	GO:0060977	coronary vasculature morphogenesis	16	17	3.13e-03
GO:BP	GO:0034505	tooth mineralization	16	17	3.13e-03
GO:BP	GO:0003215	cardiac right ventricle morphogenesis	16	17	3.13e-03
GO:BP	GO:0033135	regulation of peptidyl-serine phosphorylation	60	85	3.21e-03
GO:BP	GO:0071396	cellular response to lipid	233	388	3.24e-03
GO:BP	GO:0071496	cellular response to external stimulus	166	268	3.24e-03
GO:BP	GO:0001890	placenta development	75	110	3.25e-03
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	690	1234	3.30e-03
GO:BP	GO:0032878	regulation of establishment or maintenance of cell polarity	21	24	3.33e-03
GO:BP	GO:0003401	axis elongation	21	24	3.33e-03
GO:BP	GO:1905332	positive regulation of morphogenesis of an epithelium	21	24	3.33e-03
GO:BP	GO:0033036	macromolecule localization	1257	2309	3.34e-03
GO:BP	GO:0019229	regulation of vasoconstriction	33	42	3.70e-03
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	497	874	3.70e-03
GO:BP	GO:0010927	cellular component assembly involved in morphogenesis	73	107	3.78e-03
GO:BP	GO:0010586	miRNA metabolic process	61	87	3.79e-03
GO:BP	GO:0001508	action potential	70	102	3.81e-03
GO:BP	GO:0120162	positive regulation of cold-induced thermogenesis	50	69	3.81e-03
GO:BP	GO:0099643	signal release from synapse	70	102	3.81e-03
GO:BP	GO:0007269	neurotransmitter secretion	70	102	3.81e-03
GO:BP	GO:0060021	roof of mouth development	50	69	3.81e-03
GO:BP	GO:0043534	blood vessel endothelial cell migration	64	92	3.81e-03
GO:BP	GO:0021536	diencephalon development	31	39	3.87e-03
GO:BP	GO:0003006	developmental process involved in reproduction	334	573	3.88e-03
GO:BP	GO:0035249	synaptic transmission, glutamatergic	45	61	3.92e-03
GO:BP	GO:0001656	metanephros development	45	61	3.92e-03
GO:BP	GO:1903532	positive regulation of secretion by cell	123	193	3.92e-03
GO:BP	GO:0048662	negative regulation of smooth muscle cell proliferation	29	36	3.99e-03
GO:BP	GO:0071869	response to catecholamine	29	36	3.99e-03
GO:BP	GO:0071867	response to monoamine	29	36	3.99e-03
GO:BP	GO:0097306	cellular response to alcohol	53	74	4.02e-03
GO:BP	GO:0002792	negative regulation of peptide secretion	27	33	4.05e-03
GO:BP	GO:2000630	positive regulation of miRNA metabolic process	38	50	4.22e-03
GO:BP	GO:0010660	regulation of muscle cell apoptotic process	38	50	4.22e-03
GO:BP	GO:0048008	platelet-derived growth factor receptor signaling pathway	38	50	4.22e-03
GO:BP	GO:0010977	negative regulation of neuron projection development	74	109	4.24e-03
GO:BP	GO:0051250	negative regulation of lymphocyte activation	59	84	4.31e-03
GO:BP	GO:0051048	negative regulation of secretion	71	104	4.32e-03
GO:BP	GO:0008543	fibroblast growth factor receptor signaling pathway	43	58	4.39e-03
GO:BP	GO:0002028	regulation of sodium ion transport	43	58	4.39e-03
GO:BP	GO:0055082	intracellular chemical homeostasis	286	486	4.44e-03
GO:BP	GO:1902547	regulation of cellular response to vascular endothelial growth factor stimulus	18	20	4.46e-03
GO:BP	GO:2000116	regulation of cysteine-type endopeptidase activity	81	121	4.50e-03
GO:BP	GO:0002067	glandular epithelial cell differentiation	36	47	4.63e-03
GO:BP	GO:0086001	cardiac muscle cell action potential	46	63	4.88e-03
GO:BP	GO:0032411	positive regulation of transporter activity	46	63	4.88e-03
GO:BP	GO:0036302	atrioventricular canal development	12	12	4.89e-03
GO:BP	GO:0032332	positive regulation of chondrocyte differentiation	12	12	4.89e-03
GO:BP	GO:0099505	regulation of presynaptic membrane potential	12	12	4.89e-03
GO:BP	GO:0048871	multicellular organismal-level homeostasis	313	536	4.89e-03
GO:BP	GO:0008360	regulation of cell shape	72	106	4.89e-03
GO:BP	GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation	12	12	4.89e-03
GO:BP	GO:0007405	neuroblast proliferation	41	55	4.89e-03
GO:BP	GO:0045651	positive regulation of macrophage differentiation	12	12	4.89e-03
GO:BP	GO:0010657	muscle cell apoptotic process	41	55	4.89e-03
GO:BP	GO:0038066	p38MAPK cascade	34	44	4.99e-03
GO:BP	GO:0002042	cell migration involved in sprouting angiogenesis	34	44	4.99e-03
GO:BP	GO:1902895	positive regulation of miRNA transcription	34	44	4.99e-03
GO:BP	GO:0034103	regulation of tissue remodeling	34	44	4.99e-03
GO:BP	GO:2000177	regulation of neural precursor cell proliferation	49	68	5.20e-03
GO:BP	GO:0030162	regulation of proteolysis	247	416	5.29e-03
GO:BP	GO:0032331	negative regulation of chondrocyte differentiation	15	16	5.36e-03
GO:BP	GO:0001709	cell fate determination	20	23	5.36e-03
GO:BP	GO:0043537	negative regulation of blood vessel endothelial cell migration	20	23	5.36e-03
GO:BP	GO:0050919	negative chemotaxis	32	41	5.36e-03
GO:BP	GO:0070168	negative regulation of biomineral tissue development	15	16	5.36e-03
GO:BP	GO:0061383	trabecula morphogenesis	32	41	5.36e-03
GO:BP	GO:0031128	developmental induction	20	23	5.36e-03
GO:BP	GO:0014888	striated muscle adaptation	32	41	5.36e-03
GO:BP	GO:0060037	pharyngeal system development	20	23	5.36e-03
GO:BP	GO:0045669	positive regulation of osteoblast differentiation	39	52	5.42e-03
GO:BP	GO:0021675	nerve development	44	60	5.42e-03
GO:BP	GO:0051254	positive regulation of RNA metabolic process	751	1354	5.54e-03
GO:BP	GO:0030282	bone mineralization	55	78	5.62e-03
GO:BP	GO:0051480	regulation of cytosolic calcium ion concentration	30	38	5.72e-03
GO:BP	GO:0042752	regulation of circadian rhythm	61	88	5.78e-03
GO:BP	GO:0030099	myeloid cell differentiation	178	292	5.78e-03
GO:BP	GO:0060291	long-term synaptic potentiation	47	65	5.89e-03
GO:BP	GO:0003209	cardiac atrium morphogenesis	22	26	5.90e-03
GO:BP	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	22	26	5.90e-03
GO:BP	GO:0046651	lymphocyte proliferation	98	151	5.93e-03
GO:BP	GO:0086091	regulation of heart rate by cardiac conduction	28	35	5.97e-03
GO:BP	GO:0019933	cAMP-mediated signaling	28	35	5.97e-03
GO:BP	GO:0090278	negative regulation of peptide hormone secretion	26	32	6.11e-03
GO:BP	GO:0010656	negative regulation of muscle cell apoptotic process	26	32	6.11e-03
GO:BP	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	24	29	6.11e-03
GO:BP	GO:0010837	regulation of keratinocyte proliferation	26	32	6.11e-03
GO:BP	GO:0021954	central nervous system neuron development	42	57	6.11e-03
GO:BP	GO:0071604	transforming growth factor beta production	26	32	6.11e-03
GO:BP	GO:0060041	retina development in camera-type eye	71	105	6.30e-03
GO:BP	GO:0043068	positive regulation of programmed cell death	231	388	6.31e-03
GO:BP	GO:0045859	regulation of protein kinase activity	200	332	6.36e-03
GO:BP	GO:0030856	regulation of epithelial cell differentiation	68	100	6.44e-03
GO:BP	GO:0035725	sodium ion transmembrane transport	65	95	6.55e-03
GO:BP	GO:0016311	dephosphorylation	144	232	6.55e-03
GO:BP	GO:0010811	positive regulation of cell-substrate adhesion	65	95	6.55e-03
GO:BP	GO:0050866	negative regulation of cell activation	78	117	6.59e-03
GO:BP	GO:0035019	somatic stem cell population maintenance	35	46	6.59e-03
GO:BP	GO:0006950	response to stress	1373	2540	6.68e-03
GO:BP	GO:0034109	homotypic cell-cell adhesion	48	67	7.09e-03
GO:BP	GO:0001892	embryonic placenta development	48	67	7.09e-03
GO:BP	GO:0030217	T cell differentiation	116	183	7.20e-03
GO:BP	GO:0045665	negative regulation of neuron differentiation	33	43	7.26e-03
GO:BP	GO:0032944	regulation of mononuclear cell proliferation	79	119	7.35e-03
GO:BP	GO:0062009	secondary palate development	17	19	7.35e-03
GO:BP	GO:0055013	cardiac muscle cell development	51	72	7.37e-03
GO:BP	GO:0045995	regulation of embryonic development	51	72	7.37e-03
GO:BP	GO:0002695	negative regulation of leukocyte activation	66	97	7.45e-03
GO:BP	GO:0032943	mononuclear cell proliferation	101	157	7.54e-03
GO:BP	GO:0051279	regulation of release of sequestered calcium ion into cytosol	43	59	7.54e-03
GO:BP	GO:0046849	bone remodeling	43	59	7.54e-03
GO:BP	GO:0045621	positive regulation of lymphocyte differentiation	57	82	7.63e-03
GO:BP	GO:0010633	negative regulation of epithelial cell migration	38	51	7.67e-03
GO:BP	GO:0045936	negative regulation of phosphate metabolic process	175	288	7.70e-03
GO:BP	GO:0060326	cell chemotaxis	98	152	8.05e-03
GO:BP	GO:0032101	regulation of response to external stimulus	375	654	8.47e-03
GO:BP	GO:0062013	positive regulation of small molecule metabolic process	67	99	8.47e-03
GO:BP	GO:0050670	regulation of lymphocyte proliferation	77	116	8.52e-03
GO:BP	GO:0044843	cell cycle G1/S phase transition	127	203	8.58e-03
GO:BP	GO:0021700	developmental maturation	127	203	8.58e-03
GO:BP	GO:0071300	cellular response to retinoic acid	36	48	8.60e-03
GO:BP	GO:0002021	response to dietary excess	19	22	8.64e-03
GO:BP	GO:0097150	neuronal stem cell population maintenance	19	22	8.64e-03
GO:BP	GO:0031623	receptor internalization	61	89	8.77e-03
GO:BP	GO:0045637	regulation of myeloid cell differentiation	88	135	8.85e-03
GO:BP	GO:0070661	leukocyte proliferation	111	175	8.86e-03
GO:BP	GO:0043114	regulation of vascular permeability	27	34	8.99e-03
GO:BP	GO:0003230	cardiac atrium development	27	34	8.99e-03
GO:BP	GO:0060571	morphogenesis of an epithelial fold	14	15	9.15e-03
GO:BP	GO:0014047	glutamate secretion	14	15	9.15e-03
GO:BP	GO:0071636	positive regulation of transforming growth factor beta production	14	15	9.15e-03
GO:BP	GO:0055012	ventricular cardiac muscle cell differentiation	14	15	9.15e-03
GO:BP	GO:0035567	non-canonical Wnt signaling pathway	44	61	9.19e-03
GO:BP	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	44	61	9.19e-03
GO:BP	GO:0030857	negative regulation of epithelial cell differentiation	25	31	9.28e-03
GO:BP	GO:1900744	regulation of p38MAPK cascade	25	31	9.28e-03
GO:BP	GO:0070663	regulation of leukocyte proliferation	85	130	9.28e-03
GO:BP	GO:0090049	regulation of cell migration involved in sprouting angiogenesis	25	31	9.28e-03
GO:BP	GO:1903351	cellular response to dopamine	25	31	9.28e-03
GO:BP	GO:0060391	positive regulation of SMAD protein signal transduction	25	31	9.28e-03
GO:BP	GO:0002274	myeloid leukocyte activation	78	118	9.29e-03
GO:BP	GO:0009913	epidermal cell differentiation	78	118	9.29e-03
GO:BP	GO:0048483	autonomic nervous system development	23	28	9.40e-03
GO:BP	GO:0048841	regulation of axon extension involved in axon guidance	23	28	9.40e-03
GO:BP	GO:0010563	negative regulation of phosphorus metabolic process	175	289	9.41e-03
GO:BP	GO:0045639	positive regulation of myeloid cell differentiation	47	66	9.59e-03
GO:BP	GO:0022408	negative regulation of cell-cell adhesion	75	113	9.72e-03
GO:BP	GO:0043254	regulation of protein-containing complex assembly	196	327	9.73e-03
GO:BP	GO:0051928	positive regulation of calcium ion transport	50	71	9.88e-03
GO:BP	GO:1903038	negative regulation of leukocyte cell-cell adhesion	50	71	9.88e-03
GO:BP	GO:0001819	positive regulation of cytokine production	157	257	9.96e-03
GO:BP	GO:0007229	integrin-mediated signaling pathway	59	86	1.00e-02
GO:BP	GO:0071887	leukocyte apoptotic process	53	76	1.00e-02
GO:BP	GO:0048608	reproductive structure development	126	202	1.03e-02
GO:BP	GO:0045123	cellular extravasation	32	42	1.04e-02
GO:BP	GO:0006873	intracellular monoatomic ion homeostasis	214	360	1.05e-02
GO:BP	GO:0045862	positive regulation of proteolysis	150	245	1.12e-02
GO:BP	GO:0042098	T cell proliferation	73	110	1.13e-02
GO:BP	GO:0030177	positive regulation of Wnt signaling pathway	73	110	1.13e-02
GO:BP	GO:0043502	regulation of muscle adaptation	48	68	1.14e-02
GO:BP	GO:0055002	striated muscle cell development	48	68	1.14e-02
GO:BP	GO:0030003	intracellular monoatomic cation homeostasis	211	355	1.14e-02
GO:BP	GO:0050922	negative regulation of chemotaxis	30	39	1.15e-02
GO:BP	GO:0003014	renal system process	51	73	1.16e-02
GO:BP	GO:0034763	negative regulation of transmembrane transport	57	83	1.16e-02
GO:BP	GO:2001056	positive regulation of cysteine-type endopeptidase activity	57	83	1.16e-02
GO:BP	GO:0010976	positive regulation of neuron projection development	84	129	1.17e-02
GO:BP	GO:0008217	regulation of blood pressure	70	105	1.17e-02
GO:BP	GO:0042310	vasoconstriction	40	55	1.18e-02
GO:BP	GO:0038094	Fc-gamma receptor signaling pathway	16	18	1.20e-02
GO:BP	GO:0051968	positive regulation of synaptic transmission, glutamatergic	16	18	1.20e-02
GO:BP	GO:1903319	positive regulation of protein maturation	16	18	1.20e-02
GO:BP	GO:0055093	response to hyperoxia	16	18	1.20e-02
GO:BP	GO:0045649	regulation of macrophage differentiation	16	18	1.20e-02
GO:BP	GO:0003228	atrial cardiac muscle tissue development	16	18	1.20e-02
GO:BP	GO:1900746	regulation of vascular endothelial growth factor signaling pathway	16	18	1.20e-02
GO:BP	GO:0002763	positive regulation of myeloid leukocyte differentiation	28	36	1.24e-02
GO:BP	GO:0060443	mammary gland morphogenesis	28	36	1.24e-02
GO:BP	GO:0120032	regulation of plasma membrane bounded cell projection assembly	100	157	1.24e-02
GO:BP	GO:0051493	regulation of cytoskeleton organization	242	412	1.25e-02
GO:BP	GO:0048675	axon extension	64	95	1.25e-02
GO:BP	GO:0071214	cellular response to abiotic stimulus	153	251	1.28e-02
GO:BP	GO:0104004	cellular response to environmental stimulus	153	251	1.28e-02
GO:BP	GO:0008366	axon ensheathment	78	119	1.30e-02
GO:BP	GO:0007272	ensheathment of neurons	78	119	1.30e-02
GO:BP	GO:0048640	negative regulation of developmental growth	58	85	1.31e-02
GO:BP	GO:0032231	regulation of actin filament bundle assembly	58	85	1.31e-02
GO:BP	GO:0060491	regulation of cell projection assembly	101	159	1.32e-02
GO:BP	GO:0022414	reproductive process	491	874	1.36e-02
GO:BP	GO:0021983	pituitary gland development	18	21	1.37e-02
GO:BP	GO:0060384	innervation	18	21	1.37e-02
GO:BP	GO:0031324	negative regulation of cellular metabolic process	1051	1934	1.37e-02
GO:BP	GO:0061458	reproductive system development	127	205	1.38e-02
GO:BP	GO:0043412	macromolecule modification	1341	2489	1.39e-02
GO:BP	GO:0001937	negative regulation of endothelial cell proliferation	24	30	1.39e-02
GO:BP	GO:0046676	negative regulation of insulin secretion	24	30	1.39e-02
GO:BP	GO:0048546	digestive tract morphogenesis	24	30	1.39e-02
GO:BP	GO:0048512	circadian behavior	24	30	1.39e-02
GO:BP	GO:0007616	long-term memory	24	30	1.39e-02
GO:BP	GO:0046850	regulation of bone remodeling	24	30	1.39e-02
GO:BP	GO:0050817	coagulation	94	147	1.40e-02
GO:BP	GO:0008361	regulation of cell size	94	147	1.40e-02
GO:BP	GO:1990845	adaptive thermogenesis	79	121	1.41e-02
GO:BP	GO:0071260	cellular response to mechanical stimulus	41	57	1.42e-02
GO:BP	GO:0032147	activation of protein kinase activity	41	57	1.42e-02
GO:BP	GO:0051899	membrane depolarization	41	57	1.42e-02
GO:BP	GO:0014898	cardiac muscle hypertrophy in response to stress	20	24	1.42e-02
GO:BP	GO:0003299	muscle hypertrophy in response to stress	20	24	1.42e-02
GO:BP	GO:1990573	potassium ion import across plasma membrane	22	27	1.42e-02
GO:BP	GO:0010464	regulation of mesenchymal cell proliferation	22	27	1.42e-02
GO:BP	GO:0045124	regulation of bone resorption	20	24	1.42e-02
GO:BP	GO:0002431	Fc receptor mediated stimulatory signaling pathway	20	24	1.42e-02
GO:BP	GO:0031279	regulation of cyclase activity	22	27	1.42e-02
GO:BP	GO:0014887	cardiac muscle adaptation	20	24	1.42e-02
GO:BP	GO:0043065	positive regulation of apoptotic process	224	380	1.42e-02
GO:BP	GO:0045926	negative regulation of growth	115	184	1.44e-02
GO:BP	GO:0034446	substrate adhesion-dependent cell spreading	59	87	1.46e-02
GO:BP	GO:0030168	platelet activation	59	87	1.46e-02
GO:BP	GO:0030902	hindbrain development	69	104	1.47e-02
GO:BP	GO:0045582	positive regulation of T cell differentiation	50	72	1.52e-02
GO:BP	GO:0021533	cell differentiation in hindbrain	13	14	1.53e-02
GO:BP	GO:0043217	myelin maintenance	13	14	1.53e-02
GO:BP	GO:0010002	cardioblast differentiation	13	14	1.53e-02
GO:BP	GO:0009892	negative regulation of metabolic process	1137	2100	1.54e-02
GO:BP	GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance	10	10	1.54e-02
GO:BP	GO:0072497	mesenchymal stem cell differentiation	10	10	1.54e-02
GO:BP	GO:0045906	negative regulation of vasoconstriction	10	10	1.54e-02
GO:BP	GO:0022410	circadian sleep/wake cycle process	10	10	1.54e-02
GO:BP	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	10	10	1.54e-02
GO:BP	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	10	10	1.54e-02
GO:BP	GO:0030431	sleep	10	10	1.54e-02
GO:BP	GO:0043549	regulation of kinase activity	211	357	1.59e-02
GO:BP	GO:1903531	negative regulation of secretion by cell	63	94	1.59e-02
GO:BP	GO:0007596	blood coagulation	92	144	1.59e-02
GO:BP	GO:0050918	positive chemotaxis	29	38	1.62e-02
GO:BP	GO:0002066	columnar/cuboidal epithelial cell development	29	38	1.62e-02
GO:BP	GO:0014074	response to purine-containing compound	70	106	1.62e-02
GO:BP	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	29	38	1.62e-02
GO:BP	GO:0045103	intermediate filament-based process	29	38	1.62e-02
GO:BP	GO:0001706	endoderm formation	34	46	1.67e-02
GO:BP	GO:0033043	regulation of organelle organization	532	953	1.68e-02
GO:BP	GO:0030278	regulation of ossification	54	79	1.72e-02
GO:BP	GO:0010038	response to metal ion	151	249	1.76e-02
GO:BP	GO:0051347	positive regulation of transferase activity	156	258	1.76e-02
GO:BP	GO:0007605	sensory perception of sound	64	96	1.77e-02
GO:BP	GO:0008038	neuron recognition	27	35	1.78e-02
GO:BP	GO:0001933	negative regulation of protein phosphorylation	137	224	1.78e-02
GO:BP	GO:0042593	glucose homeostasis	106	169	1.80e-02
GO:BP	GO:0051223	regulation of protein transport	193	325	1.81e-02
GO:BP	GO:0042733	embryonic digit morphogenesis	37	51	1.82e-02
GO:BP	GO:0007599	hemostasis	94	148	1.84e-02
GO:BP	GO:0009880	embryonic pattern specification	32	43	1.89e-02
GO:BP	GO:0042129	regulation of T cell proliferation	58	86	1.91e-02
GO:BP	GO:0019725	cellular homeostasis	323	564	1.91e-02
GO:BP	GO:0098884	postsynaptic neurotransmitter receptor internalization	15	17	1.92e-02
GO:BP	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	15	17	1.92e-02
GO:BP	GO:0051590	positive regulation of neurotransmitter transport	15	17	1.92e-02
GO:BP	GO:0010954	positive regulation of protein processing	15	17	1.92e-02
GO:BP	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis	15	17	1.92e-02
GO:BP	GO:0007622	rhythmic behavior	25	32	1.92e-02
GO:BP	GO:0140239	postsynaptic endocytosis	15	17	1.92e-02
GO:BP	GO:0048169	regulation of long-term neuronal synaptic plasticity	15	17	1.92e-02
GO:BP	GO:1903350	response to dopamine	25	32	1.92e-02
GO:BP	GO:0060711	labyrinthine layer development	25	32	1.92e-02
GO:BP	GO:0007612	learning	72	110	1.95e-02
GO:BP	GO:0030879	mammary gland development	65	98	1.95e-02
GO:BP	GO:0001701	in utero embryonic development	196	331	1.98e-02
GO:BP	GO:0110053	regulation of actin filament organization	130	212	1.98e-02
GO:BP	GO:0030239	myofibril assembly	46	66	2.00e-02
GO:BP	GO:0106027	neuron projection organization	49	71	2.00e-02
GO:BP	GO:0035710	CD4-positive, alpha-beta T cell activation	46	66	2.00e-02
GO:BP	GO:0042552	myelination	76	117	2.01e-02
GO:BP	GO:0061384	heart trabecula morphogenesis	23	29	2.04e-02
GO:BP	GO:0042326	negative regulation of phosphorylation	145	239	2.04e-02
GO:BP	GO:0097106	postsynaptic density organization	23	29	2.04e-02
GO:BP	GO:0042491	inner ear auditory receptor cell differentiation	23	29	2.04e-02
GO:BP	GO:0086019	cell-cell signaling involved in cardiac conduction	23	29	2.04e-02
GO:BP	GO:0031102	neuron projection regeneration	35	48	2.05e-02
GO:BP	GO:0030500	regulation of bone mineralization	35	48	2.05e-02
GO:BP	GO:0048286	lung alveolus development	30	40	2.09e-02
GO:BP	GO:1902905	positive regulation of supramolecular fiber organization	88	138	2.09e-02
GO:BP	GO:0031281	positive regulation of cyclase activity	17	20	2.11e-02
GO:BP	GO:2000114	regulation of establishment of cell polarity	17	20	2.11e-02
GO:BP	GO:0048710	regulation of astrocyte differentiation	17	20	2.11e-02
GO:BP	GO:0048730	epidermis morphogenesis	17	20	2.11e-02
GO:BP	GO:0043588	skin development	109	175	2.12e-02
GO:BP	GO:0048806	genitalia development	21	26	2.13e-02
GO:BP	GO:1903055	positive regulation of extracellular matrix organization	21	26	2.13e-02
GO:BP	GO:0007212	dopamine receptor signaling pathway	21	26	2.13e-02
GO:BP	GO:1902656	calcium ion import into cytosol	21	26	2.13e-02
GO:BP	GO:0010765	positive regulation of sodium ion transport	19	23	2.15e-02
GO:BP	GO:0010827	regulation of glucose transmembrane transport	38	53	2.15e-02
GO:BP	GO:0003416	endochondral bone growth	19	23	2.15e-02
GO:BP	GO:0072012	glomerulus vasculature development	19	23	2.15e-02
GO:BP	GO:1904752	regulation of vascular associated smooth muscle cell migration	19	23	2.15e-02
GO:BP	GO:0043367	CD4-positive, alpha-beta T cell differentiation	38	53	2.15e-02
GO:BP	GO:0045834	positive regulation of lipid metabolic process	56	83	2.15e-02
GO:BP	GO:0045761	regulation of adenylate cyclase activity	19	23	2.15e-02
GO:BP	GO:0019216	regulation of lipid metabolic process	132	216	2.15e-02
GO:BP	GO:0010469	regulation of signaling receptor activity	41	58	2.24e-02
GO:BP	GO:0048706	embryonic skeletal system development	50	73	2.26e-02
GO:BP	GO:0048145	regulation of fibroblast proliferation	50	73	2.26e-02
GO:BP	GO:0097581	lamellipodium organization	50	73	2.26e-02
GO:BP	GO:0033500	carbohydrate homeostasis	106	170	2.27e-02
GO:BP	GO:0097061	dendritic spine organization	44	63	2.27e-02
GO:BP	GO:1903115	regulation of actin filament-based movement	28	37	2.29e-02
GO:BP	GO:0045104	intermediate filament cytoskeleton organization	28	37	2.29e-02
GO:BP	GO:0045747	positive regulation of Notch signaling pathway	28	37	2.29e-02
GO:BP	GO:0010658	striated muscle cell apoptotic process	28	37	2.29e-02
GO:BP	GO:0001818	negative regulation of cytokine production	102	163	2.30e-02
GO:BP	GO:0010761	fibroblast migration	36	50	2.48e-02
GO:BP	GO:0048814	regulation of dendrite morphogenesis	36	50	2.48e-02
GO:BP	GO:0042490	mechanoreceptor differentiation	36	50	2.48e-02
GO:BP	GO:0062012	regulation of small molecule metabolic process	140	231	2.48e-02
GO:BP	GO:1901655	cellular response to ketone	54	80	2.50e-02
GO:BP	GO:0032535	regulation of cellular component size	171	287	2.51e-02
GO:BP	GO:0008104	protein localization	1081	2000	2.51e-02
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	397	704	2.51e-02
GO:BP	GO:0010662	regulation of striated muscle cell apoptotic process	26	34	2.52e-02
GO:BP	GO:0071895	odontoblast differentiation	12	13	2.52e-02
GO:BP	GO:0010659	cardiac muscle cell apoptotic process	26	34	2.52e-02
GO:BP	GO:0048665	neuron fate specification	12	13	2.52e-02
GO:BP	GO:0099084	postsynaptic specialization organization	26	34	2.52e-02
GO:BP	GO:0046579	positive regulation of Ras protein signal transduction	12	13	2.52e-02
GO:BP	GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	12	13	2.52e-02
GO:BP	GO:0060841	venous blood vessel development	12	13	2.52e-02
GO:BP	GO:0000003	reproduction	492	882	2.52e-02
GO:BP	GO:0030033	microvillus assembly	12	13	2.52e-02
GO:BP	GO:0035315	hair cell differentiation	26	34	2.52e-02
GO:BP	GO:0009954	proximal/distal pattern formation	12	13	2.52e-02
GO:BP	GO:0001956	positive regulation of neurotransmitter secretion	12	13	2.52e-02
GO:BP	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	68	104	2.54e-02
GO:BP	GO:0070509	calcium ion import	39	55	2.54e-02
GO:BP	GO:0003073	regulation of systemic arterial blood pressure	39	55	2.54e-02
GO:BP	GO:0001954	positive regulation of cell-matrix adhesion	31	42	2.58e-02
GO:BP	GO:0048146	positive regulation of fibroblast proliferation	31	42	2.58e-02
GO:BP	GO:0051966	regulation of synaptic transmission, glutamatergic	31	42	2.58e-02
GO:BP	GO:0001938	positive regulation of endothelial cell proliferation	48	70	2.58e-02
GO:BP	GO:0048661	positive regulation of smooth muscle cell proliferation	42	60	2.59e-02
GO:BP	GO:0035418	protein localization to synapse	42	60	2.59e-02
GO:BP	GO:0030316	osteoclast differentiation	45	65	2.59e-02
GO:BP	GO:0001942	hair follicle development	45	65	2.59e-02
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	1055	1951	2.60e-02
GO:BP	GO:0110020	regulation of actomyosin structure organization	58	87	2.65e-02
GO:BP	GO:0051147	regulation of muscle cell differentiation	76	118	2.65e-02
GO:BP	GO:0050714	positive regulation of protein secretion	65	99	2.67e-02
GO:BP	GO:0046629	gamma-delta T cell activation	9	9	2.68e-02
GO:BP	GO:2000288	positive regulation of myoblast proliferation	9	9	2.68e-02
GO:BP	GO:0002024	diet induced thermogenesis	9	9	2.68e-02
GO:BP	GO:0050802	circadian sleep/wake cycle, sleep	9	9	2.68e-02
GO:BP	GO:0010838	positive regulation of keratinocyte proliferation	9	9	2.68e-02
GO:BP	GO:0099509	regulation of presynaptic cytosolic calcium ion concentration	9	9	2.68e-02
GO:BP	GO:0032060	bleb assembly	9	9	2.68e-02
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	540	973	2.68e-02
GO:BP	GO:2000739	regulation of mesenchymal stem cell differentiation	9	9	2.68e-02
GO:BP	GO:0048845	venous blood vessel morphogenesis	9	9	2.68e-02
GO:BP	GO:0001768	establishment of T cell polarity	9	9	2.68e-02
GO:BP	GO:0032906	transforming growth factor beta2 production	9	9	2.68e-02
GO:BP	GO:0032909	regulation of transforming growth factor beta2 production	9	9	2.68e-02
GO:BP	GO:0051643	endoplasmic reticulum localization	9	9	2.68e-02
GO:BP	GO:0061626	pharyngeal arch artery morphogenesis	9	9	2.68e-02
GO:BP	GO:0010665	regulation of cardiac muscle cell apoptotic process	24	31	2.72e-02
GO:BP	GO:0060688	regulation of morphogenesis of a branching structure	24	31	2.72e-02
GO:BP	GO:0034405	response to fluid shear stress	24	31	2.72e-02
GO:BP	GO:0070664	negative regulation of leukocyte proliferation	34	47	2.74e-02
GO:BP	GO:0014743	regulation of muscle hypertrophy	34	47	2.74e-02
GO:BP	GO:0045600	positive regulation of fat cell differentiation	34	47	2.74e-02
GO:BP	GO:1903317	regulation of protein maturation	34	47	2.74e-02
GO:BP	GO:0007584	response to nutrient	73	113	2.79e-02
GO:BP	GO:0061024	membrane organization	354	625	2.81e-02
GO:BP	GO:0007179	transforming growth factor beta receptor signaling pathway	106	171	2.82e-02
GO:BP	GO:0045619	regulation of lymphocyte differentiation	81	127	2.85e-02
GO:BP	GO:0042311	vasodilation	29	39	2.86e-02
GO:BP	GO:0051965	positive regulation of synapse assembly	29	39	2.86e-02
GO:BP	GO:0035904	aorta development	37	52	2.87e-02
GO:BP	GO:1904427	positive regulation of calcium ion transmembrane transport	37	52	2.87e-02
GO:BP	GO:0070727	cellular macromolecule localization	1085	2010	2.87e-02
GO:BP	GO:0003171	atrioventricular valve development	22	28	2.92e-02
GO:BP	GO:0022405	hair cycle process	46	67	2.92e-02
GO:BP	GO:0022404	molting cycle process	46	67	2.92e-02
GO:BP	GO:0048713	regulation of oligodendrocyte differentiation	22	28	2.92e-02
GO:BP	GO:0060317	cardiac epithelial to mesenchymal transition	22	28	2.92e-02
GO:BP	GO:0044331	cell-cell adhesion mediated by cadherin	22	28	2.92e-02
GO:BP	GO:0031503	protein-containing complex localization	98	157	2.93e-02
GO:BP	GO:0086014	atrial cardiac muscle cell action potential	14	16	2.99e-02
GO:BP	GO:0086026	atrial cardiac muscle cell to AV node cell signaling	14	16	2.99e-02
GO:BP	GO:0021846	cell proliferation in forebrain	14	16	2.99e-02
GO:BP	GO:0003128	heart field specification	14	16	2.99e-02
GO:BP	GO:0086066	atrial cardiac muscle cell to AV node cell communication	14	16	2.99e-02
GO:BP	GO:1900274	regulation of phospholipase C activity	14	16	2.99e-02
GO:BP	GO:0045762	positive regulation of adenylate cyclase activity	14	16	2.99e-02
GO:BP	GO:0019827	stem cell population maintenance	90	143	3.00e-02
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	535	965	3.01e-02
GO:BP	GO:1904738	vascular associated smooth muscle cell migration	20	25	3.09e-02
GO:BP	GO:0061437	renal system vasculature development	20	25	3.09e-02
GO:BP	GO:0007435	salivary gland morphogenesis	20	25	3.09e-02
GO:BP	GO:0061440	kidney vasculature development	20	25	3.09e-02
GO:BP	GO:0098703	calcium ion import across plasma membrane	20	25	3.09e-02
GO:BP	GO:0007623	circadian rhythm	95	152	3.15e-02
GO:BP	GO:0030038	contractile actin filament bundle assembly	60	91	3.17e-02
GO:BP	GO:0043149	stress fiber assembly	60	91	3.17e-02
GO:BP	GO:0038179	neurotrophin signaling pathway	27	36	3.17e-02
GO:BP	GO:0035306	positive regulation of dephosphorylation	27	36	3.17e-02
GO:BP	GO:0060512	prostate gland morphogenesis	16	19	3.17e-02
GO:BP	GO:0098810	neurotransmitter reuptake	16	19	3.17e-02
GO:BP	GO:1990806	ligand-gated ion channel signaling pathway	16	19	3.17e-02
GO:BP	GO:0099590	neurotransmitter receptor internalization	16	19	3.17e-02
GO:BP	GO:0060740	prostate gland epithelium morphogenesis	16	19	3.17e-02
GO:BP	GO:1901201	regulation of extracellular matrix assembly	16	19	3.17e-02
GO:BP	GO:0042092	type 2 immune response	16	19	3.17e-02
GO:BP	GO:0003338	metanephros morphogenesis	16	19	3.17e-02
GO:BP	GO:0097529	myeloid leukocyte migration	71	110	3.17e-02
GO:BP	GO:0055075	potassium ion homeostasis	18	22	3.18e-02
GO:BP	GO:0030279	negative regulation of ossification	18	22	3.18e-02
GO:BP	GO:0031400	negative regulation of protein modification process	191	325	3.18e-02
GO:BP	GO:1904705	regulation of vascular associated smooth muscle cell proliferation	35	49	3.24e-02
GO:BP	GO:0018107	peptidyl-threonine phosphorylation	47	69	3.28e-02
GO:BP	GO:1990778	protein localization to cell periphery	170	287	3.34e-02
GO:BP	GO:0016239	positive regulation of macroautophagy	44	64	3.34e-02
GO:BP	GO:0050868	negative regulation of T cell activation	44	64	3.34e-02
GO:BP	GO:0050772	positive regulation of axonogenesis	44	64	3.34e-02
GO:BP	GO:0140238	presynaptic endocytosis	41	59	3.36e-02
GO:BP	GO:2000045	regulation of G1/S transition of mitotic cell cycle	88	140	3.41e-02
GO:BP	GO:0106106	cold-induced thermogenesis	72	112	3.42e-02
GO:BP	GO:1903034	regulation of response to wounding	76	119	3.45e-02
GO:BP	GO:0046683	response to organophosphorus	61	93	3.46e-02
GO:BP	GO:0010171	body morphogenesis	30	41	3.49e-02
GO:BP	GO:0045453	bone resorption	30	41	3.49e-02
GO:BP	GO:0007600	sensory perception	150	251	3.50e-02
GO:BP	GO:1902692	regulation of neuroblast proliferation	25	33	3.51e-02
GO:BP	GO:0038093	Fc receptor signaling pathway	25	33	3.51e-02
GO:BP	GO:0018210	peptidyl-threonine modification	51	76	3.58e-02
GO:BP	GO:0060996	dendritic spine development	51	76	3.58e-02
GO:BP	GO:0007219	Notch signaling pathway	89	142	3.63e-02
GO:BP	GO:0030595	leukocyte chemotaxis	69	107	3.65e-02
GO:BP	GO:0032880	regulation of protein localization	388	691	3.70e-02
GO:BP	GO:0001655	urogenital system development	33	46	3.71e-02
GO:BP	GO:0010611	regulation of cardiac muscle hypertrophy	33	46	3.71e-02
GO:BP	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	33	46	3.71e-02
GO:BP	GO:0062014	negative regulation of small molecule metabolic process	48	71	3.71e-02
GO:BP	GO:1904036	negative regulation of epithelial cell apoptotic process	33	46	3.71e-02
GO:BP	GO:0007265	Ras protein signal transduction	62	95	3.78e-02
GO:BP	GO:0051153	regulation of striated muscle cell differentiation	45	66	3.80e-02
GO:BP	GO:0006887	exocytosis	142	237	3.83e-02
GO:BP	GO:0050771	negative regulation of axonogenesis	36	51	3.83e-02
GO:BP	GO:0043266	regulation of potassium ion transport	42	61	3.85e-02
GO:BP	GO:0031668	cellular response to extracellular stimulus	132	219	3.85e-02
GO:BP	GO:0033273	response to vitamin	42	61	3.85e-02
GO:BP	GO:0002088	lens development in camera-type eye	39	56	3.87e-02
GO:BP	GO:1904019	epithelial cell apoptotic process	66	102	3.87e-02
GO:BP	GO:0052652	cyclic purine nucleotide metabolic process	23	30	3.88e-02
GO:BP	GO:0014911	positive regulation of smooth muscle cell migration	23	30	3.88e-02
GO:BP	GO:0001659	temperature homeostasis	82	130	3.93e-02
GO:BP	GO:2001222	regulation of neuron migration	28	38	3.94e-02
GO:BP	GO:0006940	regulation of smooth muscle contraction	28	38	3.94e-02
GO:BP	GO:0045668	negative regulation of osteoblast differentiation	28	38	3.94e-02
GO:BP	GO:0061005	cell differentiation involved in kidney development	28	38	3.94e-02
GO:BP	GO:0052548	regulation of endopeptidase activity	95	153	3.97e-02
GO:BP	GO:0050773	regulation of dendrite development	52	78	3.97e-02
GO:BP	GO:0046942	carboxylic acid transport	123	203	3.98e-02
GO:BP	GO:0072578	neurotransmitter-gated ion channel clustering	11	12	4.07e-02
GO:BP	GO:0045780	positive regulation of bone resorption	11	12	4.07e-02
GO:BP	GO:0048368	lateral mesoderm development	11	12	4.07e-02
GO:BP	GO:0003222	ventricular trabecula myocardium morphogenesis	11	12	4.07e-02
GO:BP	GO:0061154	endothelial tube morphogenesis	11	12	4.07e-02
GO:BP	GO:0003207	cardiac chamber formation	11	12	4.07e-02
GO:BP	GO:0055057	neuroblast division	11	12	4.07e-02
GO:BP	GO:0003159	morphogenesis of an endothelium	11	12	4.07e-02
GO:BP	GO:0030539	male genitalia development	11	12	4.07e-02
GO:BP	GO:0031669	cellular response to nutrient levels	119	196	4.12e-02
GO:BP	GO:0001558	regulation of cell growth	189	323	4.13e-02
GO:BP	GO:0038127	ERBB signaling pathway	67	104	4.16e-02
GO:BP	GO:0051651	maintenance of location in cell	105	171	4.16e-02
GO:BP	GO:0051253	negative regulation of RNA metabolic process	587	1067	4.18e-02
GO:BP	GO:0120161	regulation of cold-induced thermogenesis	71	111	4.18e-02
GO:BP	GO:1901021	positive regulation of calcium ion transmembrane transporter activity	21	27	4.18e-02
GO:BP	GO:0120033	negative regulation of plasma membrane bounded cell projection assembly	21	27	4.18e-02
GO:BP	GO:0010517	regulation of phospholipase activity	21	27	4.18e-02
GO:BP	GO:0035909	aorta morphogenesis	21	27	4.18e-02
GO:BP	GO:0031333	negative regulation of protein-containing complex assembly	75	118	4.18e-02
GO:BP	GO:0002294	CD4-positive, alpha-beta T cell differentiation involved in immune response	31	43	4.18e-02
GO:BP	GO:0030514	negative regulation of BMP signaling pathway	31	43	4.18e-02
GO:BP	GO:0042093	T-helper cell differentiation	31	43	4.18e-02
GO:BP	GO:0070570	regulation of neuron projection regeneration	21	27	4.18e-02
GO:BP	GO:0032945	negative regulation of mononuclear cell proliferation	31	43	4.18e-02
GO:BP	GO:0002293	alpha-beta T cell differentiation involved in immune response	31	43	4.18e-02
GO:BP	GO:0050672	negative regulation of lymphocyte proliferation	31	43	4.18e-02
GO:BP	GO:0002287	alpha-beta T cell activation involved in immune response	31	43	4.18e-02
GO:BP	GO:0150104	transport across blood-brain barrier	46	68	4.20e-02
GO:BP	GO:0010232	vascular transport	46	68	4.20e-02
GO:BP	GO:0060249	anatomical structure homeostasis	101	164	4.24e-02
GO:BP	GO:0001894	tissue homeostasis	101	164	4.24e-02
GO:BP	GO:0010629	negative regulation of gene expression	440	790	4.24e-02
GO:BP	GO:0060113	inner ear receptor cell differentiation	34	48	4.32e-02
GO:BP	GO:0048488	synaptic vesicle endocytosis	40	58	4.38e-02
GO:BP	GO:0033138	positive regulation of peptidyl-serine phosphorylation	40	58	4.38e-02
GO:BP	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	26	35	4.38e-02
GO:BP	GO:0034113	heterotypic cell-cell adhesion	26	35	4.38e-02
GO:BP	GO:0010508	positive regulation of autophagy	80	127	4.43e-02
GO:BP	GO:0098781	ncRNA transcription	76	120	4.47e-02
GO:BP	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	19	24	4.49e-02
GO:BP	GO:0033280	response to vitamin D	19	24	4.49e-02
GO:BP	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	19	24	4.49e-02
GO:BP	GO:0022011	myelination in peripheral nervous system	19	24	4.49e-02
GO:BP	GO:0032292	peripheral nervous system axon ensheathment	19	24	4.49e-02
GO:BP	GO:0001958	endochondral ossification	19	24	4.49e-02
GO:BP	GO:0098868	bone growth	19	24	4.49e-02
GO:BP	GO:0036075	replacement ossification	19	24	4.49e-02
GO:BP	GO:0030534	adult behavior	57	87	4.50e-02
GO:BP	GO:0042303	molting cycle	50	75	4.50e-02
GO:BP	GO:0007204	positive regulation of cytosolic calcium ion concentration	50	75	4.50e-02
GO:BP	GO:0042633	hair cycle	50	75	4.50e-02
GO:BP	GO:0097152	mesenchymal cell apoptotic process	8	8	4.56e-02
GO:BP	GO:0045187	regulation of circadian sleep/wake cycle, sleep	8	8	4.56e-02
GO:BP	GO:0036462	TRAIL-activated apoptotic signaling pathway	8	8	4.56e-02
GO:BP	GO:0071389	cellular response to mineralocorticoid stimulus	8	8	4.56e-02
GO:BP	GO:0040034	regulation of development, heterochronic	8	8	4.56e-02
GO:BP	GO:0060982	coronary artery morphogenesis	8	8	4.56e-02
GO:BP	GO:0048505	regulation of timing of cell differentiation	8	8	4.56e-02
GO:BP	GO:0048715	negative regulation of oligodendrocyte differentiation	8	8	4.56e-02
GO:BP	GO:0003190	atrioventricular valve formation	8	8	4.56e-02
GO:BP	GO:0032674	regulation of interleukin-5 production	8	8	4.56e-02
GO:BP	GO:0060896	neural plate pattern specification	8	8	4.56e-02
GO:BP	GO:0032634	interleukin-5 production	8	8	4.56e-02
GO:BP	GO:2000651	positive regulation of sodium ion transmembrane transporter activity	8	8	4.56e-02
GO:BP	GO:1900116	extracellular negative regulation of signal transduction	8	8	4.56e-02
GO:BP	GO:0099624	atrial cardiac muscle cell membrane repolarization	8	8	4.56e-02
GO:BP	GO:1900115	extracellular regulation of signal transduction	8	8	4.56e-02
GO:BP	GO:0003149	membranous septum morphogenesis	8	8	4.56e-02
GO:BP	GO:0003418	growth plate cartilage chondrocyte differentiation	8	8	4.56e-02
GO:BP	GO:0018193	peptidyl-amino acid modification	314	555	4.56e-02
GO:BP	GO:0002828	regulation of type 2 immune response	13	15	4.58e-02
GO:BP	GO:0051546	keratinocyte migration	13	15	4.58e-02
GO:BP	GO:1902932	positive regulation of alcohol biosynthetic process	13	15	4.58e-02
GO:BP	GO:0072170	metanephric tubule development	13	15	4.58e-02
GO:BP	GO:0060413	atrial septum morphogenesis	13	15	4.58e-02
GO:BP	GO:1902683	regulation of receptor localization to synapse	13	15	4.58e-02
GO:BP	GO:0070571	negative regulation of neuron projection regeneration	13	15	4.58e-02
GO:BP	GO:0032891	negative regulation of organic acid transport	13	15	4.58e-02
GO:BP	GO:0016079	synaptic vesicle exocytosis	47	70	4.60e-02
GO:BP	GO:1900745	positive regulation of p38MAPK cascade	17	21	4.66e-02
GO:BP	GO:2000178	negative regulation of neural precursor cell proliferation	17	21	4.66e-02
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	879	1624	4.67e-02
GO:BP	GO:0015849	organic acid transport	123	204	4.71e-02
GO:BP	GO:0051495	positive regulation of cytoskeleton organization	90	145	4.71e-02
GO:BP	GO:0098727	maintenance of cell number	90	145	4.71e-02
GO:BP	GO:0032869	cellular response to insulin stimulus	99	161	4.71e-02
GO:BP	GO:0032925	regulation of activin receptor signaling pathway	15	18	4.74e-02
GO:BP	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	15	18	4.74e-02
GO:BP	GO:0031069	hair follicle morphogenesis	15	18	4.74e-02
GO:BP	GO:0033032	regulation of myeloid cell apoptotic process	15	18	4.74e-02
GO:BP	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	15	18	4.74e-02
GO:BP	GO:1902903	regulation of supramolecular fiber organization	178	304	4.77e-02
GO:BP	GO:0030501	positive regulation of bone mineralization	24	32	4.78e-02
GO:BP	GO:0042220	response to cocaine	24	32	4.78e-02
GO:BP	GO:0062237	protein localization to postsynapse	24	32	4.78e-02
GO:BP	GO:0070884	regulation of calcineurin-NFAT signaling cascade	24	32	4.78e-02
GO:BP	GO:0106056	regulation of calcineurin-mediated signaling	24	32	4.78e-02
GO:BP	GO:1903539	protein localization to postsynaptic membrane	24	32	4.78e-02
GO:BP	GO:0086004	regulation of cardiac muscle cell contraction	24	32	4.78e-02
GO:BP	GO:0050709	negative regulation of protein secretion	32	45	4.80e-02
GO:BP	GO:0002292	T cell differentiation involved in immune response	32	45	4.80e-02
GO:BP	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	32	45	4.80e-02
GO:BP	GO:0007548	sex differentiation	109	179	4.80e-02
GO:BP	GO:0060997	dendritic spine morphogenesis	32	45	4.80e-02
GO:BP	GO:0046486	glycerolipid metabolic process	167	284	4.81e-02
GO:BP	GO:0051492	regulation of stress fiber assembly	51	77	4.85e-02
GO:BP	GO:0010950	positive regulation of endopeptidase activity	62	96	4.88e-02
GO:BP	GO:0070527	platelet aggregation	35	50	4.88e-02
GO:BP	GO:0051145	smooth muscle cell differentiation	38	55	4.88e-02
GO:BP	GO:1901019	regulation of calcium ion transmembrane transporter activity	35	50	4.88e-02
GO:BP	GO:0031016	pancreas development	35	50	4.88e-02
GO:BP	GO:0030041	actin filament polymerization	78	124	4.90e-02
GO:BP	GO:0046718	symbiont entry into host cell	66	103	4.94e-02
GO:BP	GO:0050954	sensory perception of mechanical stimulus	70	110	4.96e-02

ESRnomtable %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in ESR neargenes") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in ESR neargenes

source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:04510	Focal adhesion	128	169	4.34e-09
KEGG	KEGG:05200	Pathways in cancer	263	391	4.34e-09
KEGG	KEGG:04020	Calcium signaling pathway	123	161	4.34e-09
KEGG	KEGG:04015	Rap1 signaling pathway	121	162	3.73e-08
KEGG	KEGG:04925	Aldosterone synthesis and secretion	64	75	3.73e-08
KEGG	KEGG:04024	cAMP signaling pathway	111	147	5.35e-08
KEGG	KEGG:04360	Axon guidance	114	155	3.91e-07
KEGG	KEGG:04310	Wnt signaling pathway	98	133	3.28e-06
KEGG	KEGG:04911	Insulin secretion	51	62	1.25e-05
KEGG	KEGG:05414	Dilated cardiomyopathy	64	82	1.36e-05
KEGG	KEGG:05205	Proteoglycans in cancer	114	162	1.36e-05
KEGG	KEGG:04970	Salivary secretion	45	54	2.12e-05
KEGG	KEGG:04261	Adrenergic signaling in cardiomyocytes	90	124	2.12e-05
KEGG	KEGG:04022	cGMP-PKG signaling pathway	93	129	2.14e-05
KEGG	KEGG:04520	Adherens junction	64	83	2.19e-05
KEGG	KEGG:04724	Glutamatergic synapse	58	74	2.54e-05
KEGG	KEGG:04927	Cortisol synthesis and secretion	39	46	3.73e-05
KEGG	KEGG:04014	Ras signaling pathway	113	164	4.85e-05
KEGG	KEGG:04512	ECM-receptor interaction	52	66	5.79e-05
KEGG	KEGG:04971	Gastric acid secretion	42	51	6.00e-05
KEGG	KEGG:04010	MAPK signaling pathway	152	231	6.12e-05
KEGG	KEGG:04151	PI3K-Akt signaling pathway	163	250	6.12e-05
KEGG	KEGG:04390	Hippo signaling pathway	91	129	7.77e-05
KEGG	KEGG:04924	Renin secretion	41	50	8.12e-05
KEGG	KEGG:04919	Thyroid hormone signaling pathway	76	105	9.35e-05
KEGG	KEGG:05412	Arrhythmogenic right ventricular cardiomyopathy	52	67	9.52e-05
KEGG	KEGG:04810	Regulation of actin cytoskeleton	114	169	1.36e-04
KEGG	KEGG:05410	Hypertrophic cardiomyopathy	58	77	1.36e-04
KEGG	KEGG:04934	Cushing syndrome	84	119	1.36e-04
KEGG	KEGG:04972	Pancreatic secretion	45	57	1.50e-04
KEGG	KEGG:04725	Cholinergic synapse	61	82	1.50e-04
KEGG	KEGG:04921	Oxytocin signaling pathway	80	113	1.66e-04
KEGG	KEGG:04974	Protein digestion and absorption	44	56	2.20e-04
KEGG	KEGG:04611	Platelet activation	64	88	2.84e-04
KEGG	KEGG:04713	Circadian entrainment	51	68	4.58e-04
KEGG	KEGG:04670	Leukocyte transendothelial migration	56	76	4.58e-04
KEGG	KEGG:04750	Inflammatory mediator regulation of TRP channels	53	72	7.33e-04
KEGG	KEGG:05224	Breast cancer	78	113	7.33e-04
KEGG	KEGG:04514	Cell adhesion molecules	51	69	8.01e-04
KEGG	KEGG:04923	Regulation of lipolysis in adipocytes	33	41	8.50e-04
KEGG	KEGG:04072	Phospholipase D signaling pathway	74	107	9.33e-04
KEGG	KEGG:04928	Parathyroid hormone synthesis, secretion and action	56	78	1.27e-03
KEGG	KEGG:04961	Endocrine and other factor-regulated calcium reabsorption	32	40	1.27e-03
KEGG	KEGG:05032	Morphine addiction	41	54	1.28e-03
KEGG	KEGG:05226	Gastric cancer	77	113	1.33e-03
KEGG	KEGG:04916	Melanogenesis	54	75	1.37e-03
KEGG	KEGG:04148	Efferocytosis	81	120	1.41e-03
KEGG	KEGG:05225	Hepatocellular carcinoma	91	137	1.41e-03
KEGG	KEGG:05218	Melanoma	42	56	1.55e-03
KEGG	KEGG:04728	Dopaminergic synapse	67	97	1.66e-03
KEGG	KEGG:04270	Vascular smooth muscle contraction	64	92	1.66e-03
KEGG	KEGG:04726	Serotonergic synapse	43	58	1.91e-03
KEGG	KEGG:04550	Signaling pathways regulating pluripotency of stem cells	69	101	2.16e-03
KEGG	KEGG:05202	Transcriptional misregulation in cancer	81	122	2.82e-03
KEGG	KEGG:04371	Apelin signaling pathway	70	104	3.70e-03
KEGG	KEGG:04935	Growth hormone synthesis, secretion and action	65	96	4.41e-03
KEGG	KEGG:05165	Human papillomavirus infection	154	252	4.67e-03
KEGG	KEGG:04213	Longevity regulating pathway - multiple species	37	50	4.67e-03
KEGG	KEGG:04929	GnRH secretion	37	50	4.67e-03
KEGG	KEGG:05163	Human cytomegalovirus infection	102	160	4.67e-03
KEGG	KEGG:04926	Relaxin signaling pathway	67	100	5.25e-03
KEGG	KEGG:04915	Estrogen signaling pathway	61	90	5.53e-03
KEGG	KEGG:04727	GABAergic synapse	38	52	5.68e-03
KEGG	KEGG:04976	Bile secretion	31	41	6.23e-03
KEGG	KEGG:04340	Hedgehog signaling pathway	36	49	6.23e-03
KEGG	KEGG:04933	AGE-RAGE signaling pathway in diabetic complications	59	87	6.23e-03
KEGG	KEGG:04530	Tight junction	83	129	8.32e-03
KEGG	KEGG:04540	Gap junction	49	71	8.54e-03
KEGG	KEGG:04742	Taste transduction	17	20	9.03e-03
KEGG	KEGG:05230	Central carbon metabolism in cancer	41	58	9.57e-03
KEGG	KEGG:04380	Osteoclast differentiation	61	92	1.11e-02
KEGG	KEGG:05214	Glioma	45	65	1.12e-02
KEGG	KEGG:04060	Cytokine-cytokine receptor interaction	62	94	1.21e-02
KEGG	KEGG:04152	AMPK signaling pathway	66	101	1.25e-02
KEGG	KEGG:05146	Amoebiasis	43	62	1.27e-02
KEGG	KEGG:04931	Insulin resistance	60	91	1.37e-02
KEGG	KEGG:05210	Colorectal cancer	54	81	1.50e-02
KEGG	KEGG:05206	MicroRNAs in cancer	90	144	1.65e-02
KEGG	KEGG:04720	Long-term potentiation	36	51	1.65e-02
KEGG	KEGG:04922	Glucagon signaling pathway	52	78	1.68e-02
KEGG	KEGG:04350	TGF-beta signaling pathway	59	90	1.68e-02
KEGG	KEGG:04012	ErbB signaling pathway	50	75	1.96e-02
KEGG	KEGG:05222	Small cell lung cancer	54	82	2.04e-02
KEGG	KEGG:01522	Endocrine resistance	54	82	2.04e-02
KEGG	KEGG:05031	Amphetamine addiction	32	45	2.11e-02
KEGG	KEGG:04071	Sphingolipid signaling pathway	66	103	2.16e-02
KEGG	KEGG:01521	EGFR tyrosine kinase inhibitor resistance	48	72	2.19e-02
KEGG	KEGG:04973	Carbohydrate digestion and absorption	22	29	2.30e-02
KEGG	KEGG:04066	HIF-1 signaling pathway	56	86	2.36e-02
KEGG	KEGG:00000	KEGG root term	2855	5451	2.47e-02
KEGG	KEGG:00051	Fructose and mannose metabolism	20	26	2.47e-02
KEGG	KEGG:04913	Ovarian steroidogenesis	20	26	2.47e-02
KEGG	KEGG:04730	Long-term depression	28	39	2.65e-02
KEGG	KEGG:05213	Endometrial cancer	37	54	2.68e-02
KEGG	KEGG:04666	Fc gamma R-mediated phagocytosis	49	75	3.31e-02
KEGG	KEGG:04659	Th17 cell differentiation	40	60	3.92e-02
KEGG	KEGG:05131	Shigellosis	121	204	3.93e-02
KEGG	KEGG:05207	Chemical carcinogenesis - receptor activation	81	132	3.98e-02
KEGG	KEGG:04625	C-type lectin receptor signaling pathway	48	74	4.08e-02
KEGG	KEGG:00514	Other types of O-glycan biosynthesis	25	35	4.08e-02
KEGG	KEGG:04912	GnRH signaling pathway	48	74	4.08e-02
KEGG	KEGG:04930	Type II diabetes mellitus	25	35	4.08e-02
KEGG	KEGG:04061	Viral protein interaction with cytokine and cytokine receptor	15	19	4.25e-02
KEGG	KEGG:04614	Renin-angiotensin system	9	10	4.35e-02
KEGG	KEGG:05033	Nicotine addiction	9	10	4.35e-02
KEGG	KEGG:00564	Glycerophospholipid metabolism	46	71	4.58e-02
KEGG	KEGG:05030	Cocaine addiction	23	32	4.59e-02
KEGG	KEGG:04080	Neuroactive ligand-receptor interaction	63	101	4.76e-02
KEGG	KEGG:05231	Choline metabolism in cancer	51	80	4.91e-02

LR response genes

# LR_resgenes <- gost(query = LR_NG_list$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(LR_resgenes,"data/GO_KEGG_analysis/LR_resgenes.RDS")

LRnom <- gostplot(LR_resgenes, capped = FALSE, interactive = TRUE)
# LRnom

LRnomtable <- LR_resgenes$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

LRnomtable %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in LR neargenes" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in LR neargenes

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0032501	multicellular organismal process	3517	4504	2.85e-37
GO:BP	GO:0048731	system development	2194	2719	1.88e-35
GO:BP	GO:0007154	cell communication	3123	3983	2.81e-34
GO:BP	GO:0009653	anatomical structure morphogenesis	1527	1844	8.13e-34
GO:BP	GO:0048856	anatomical structure development	3035	3867	8.13e-34
GO:BP	GO:0023052	signaling	3073	3918	8.13e-34
GO:BP	GO:0007275	multicellular organism development	2520	3170	1.90e-33
GO:BP	GO:0032502	developmental process	3261	4179	1.90e-33
GO:BP	GO:0007165	signal transduction	2834	3611	9.26e-31
GO:BP	GO:0050896	response to stimulus	4108	5379	4.91e-29
GO:BP	GO:0051716	cellular response to stimulus	3575	4640	6.17e-29
GO:BP	GO:0007399	nervous system development	1449	1775	5.17e-26
GO:BP	GO:0022008	neurogenesis	1048	1251	8.68e-26
GO:BP	GO:0048869	cellular developmental process	2217	2804	1.25e-25
GO:BP	GO:0030154	cell differentiation	2216	2803	1.35e-25
GO:BP	GO:0048513	animal organ development	1616	2004	1.66e-24
GO:BP	GO:0050793	regulation of developmental process	1384	1697	2.10e-24
GO:BP	GO:0048699	generation of neurons	907	1076	7.45e-24
GO:BP	GO:0007166	cell surface receptor signaling pathway	1460	1801	1.06e-23
GO:BP	GO:0010646	regulation of cell communication	1940	2444	2.20e-23
GO:BP	GO:0030182	neuron differentiation	856	1014	7.74e-23
GO:BP	GO:0023051	regulation of signaling	1933	2438	8.19e-23
GO:BP	GO:0051239	regulation of multicellular organismal process	1547	1924	2.85e-22
GO:BP	GO:0016477	cell migration	848	1011	7.88e-21
GO:BP	GO:0007155	cell adhesion	791	941	7.79e-20
GO:BP	GO:0009887	animal organ morphogenesis	581	673	1.35e-19
GO:BP	GO:0048583	regulation of response to stimulus	2124	2717	1.94e-19
GO:BP	GO:0009966	regulation of signal transduction	1713	2166	9.59e-19
GO:BP	GO:0048468	cell development	1504	1886	1.08e-18
GO:BP	GO:0048870	cell motility	924	1120	2.51e-18
GO:BP	GO:0009888	tissue development	1096	1348	7.00e-18
GO:BP	GO:0000902	cell morphogenesis	607	713	1.85e-17
GO:BP	GO:0007267	cell-cell signaling	892	1082	1.86e-17
GO:BP	GO:0003008	system process	935	1139	2.58e-17
GO:BP	GO:0040012	regulation of locomotion	612	720	2.58e-17
GO:BP	GO:2000145	regulation of cell motility	596	700	3.50e-17
GO:BP	GO:0072359	circulatory system development	723	864	4.90e-17
GO:BP	GO:0035295	tube development	663	787	6.44e-17
GO:BP	GO:0030334	regulation of cell migration	570	668	7.71e-17
GO:BP	GO:0051094	positive regulation of developmental process	760	913	8.43e-17
GO:BP	GO:0031175	neuron projection development	628	743	1.18e-16
GO:BP	GO:0040011	locomotion	676	805	1.28e-16
GO:BP	GO:0048666	neuron development	701	838	1.92e-16
GO:BP	GO:0035239	tube morphogenesis	545	638	2.70e-16
GO:BP	GO:0032989	cellular anatomical entity morphogenesis	505	588	5.26e-16
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	698	837	1.02e-15
GO:BP	GO:0048522	positive regulation of cellular process	3005	3954	1.16e-15
GO:BP	GO:0050789	regulation of biological process	5544	7516	1.29e-15
GO:BP	GO:0030030	cell projection organization	961	1182	1.55e-15
GO:BP	GO:0048518	positive regulation of biological process	3254	4301	2.05e-15
GO:BP	GO:2000026	regulation of multicellular organismal development	784	951	2.95e-15
GO:BP	GO:0048858	cell projection morphogenesis	432	498	3.12e-15
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	935	1150	4.30e-15
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	603	717	4.94e-15
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	428	494	6.88e-15
GO:BP	GO:0048812	neuron projection morphogenesis	416	479	7.60e-15
GO:BP	GO:0001568	blood vessel development	452	525	1.08e-14
GO:BP	GO:0051093	negative regulation of developmental process	528	622	1.14e-14
GO:BP	GO:0045595	regulation of cell differentiation	874	1073	1.96e-14
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	517	609	2.32e-14
GO:BP	GO:0050794	regulation of cellular process	5279	7153	2.55e-14
GO:BP	GO:0001944	vasculature development	472	552	3.18e-14
GO:BP	GO:0065007	biological regulation	5684	7734	8.19e-14
GO:BP	GO:0051240	positive regulation of multicellular organismal process	845	1040	2.20e-13
GO:BP	GO:0141124	intracellular signaling cassette	1051	1314	3.49e-13
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	377	435	4.36e-13
GO:BP	GO:0071495	cellular response to endogenous stimulus	840	1035	4.46e-13
GO:BP	GO:0065008	regulation of biological quality	1480	1893	1.18e-12
GO:BP	GO:0034330	cell junction organization	461	545	3.79e-12
GO:BP	GO:0051128	regulation of cellular component organization	1454	1862	4.53e-12
GO:BP	GO:0048514	blood vessel morphogenesis	386	450	6.46e-12
GO:BP	GO:0045597	positive regulation of cell differentiation	496	591	6.75e-12
GO:BP	GO:0098609	cell-cell adhesion	475	564	6.89e-12
GO:BP	GO:0001503	ossification	268	302	8.52e-12
GO:BP	GO:0009719	response to endogenous stimulus	957	1197	8.53e-12
GO:BP	GO:0048519	negative regulation of biological process	2841	3764	8.92e-12
GO:BP	GO:0048589	developmental growth	425	501	1.43e-11
GO:BP	GO:0048523	negative regulation of cellular process	2682	3550	3.51e-11
GO:BP	GO:0045596	negative regulation of cell differentiation	385	452	6.08e-11
GO:BP	GO:0072001	renal system development	219	244	1.04e-10
GO:BP	GO:0030155	regulation of cell adhesion	428	508	1.07e-10
GO:BP	GO:0035556	intracellular signal transduction	1511	1951	1.59e-10
GO:BP	GO:0007409	axonogenesis	293	337	2.10e-10
GO:BP	GO:0060429	epithelium development	645	792	2.40e-10
GO:BP	GO:0044057	regulation of system process	330	384	2.44e-10
GO:BP	GO:0007417	central nervous system development	570	694	2.75e-10
GO:BP	GO:0002062	chondrocyte differentiation	87	88	3.70e-10
GO:BP	GO:0001822	kidney development	212	237	5.13e-10
GO:BP	GO:0003013	circulatory system process	362	426	5.59e-10
GO:BP	GO:0010975	regulation of neuron projection development	306	355	6.78e-10
GO:BP	GO:0051960	regulation of nervous system development	293	339	9.50e-10
GO:BP	GO:0061564	axon development	319	372	9.59e-10
GO:BP	GO:0006810	transport	2261	2984	9.59e-10
GO:BP	GO:0051049	regulation of transport	873	1098	1.14e-09
GO:BP	GO:0042221	response to chemical	1764	2304	1.45e-09
GO:BP	GO:0051179	localization	2800	3731	1.60e-09
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	422	505	1.66e-09
GO:BP	GO:0098657	import into cell	512	622	1.70e-09
GO:BP	GO:0030900	forebrain development	239	272	1.84e-09
GO:BP	GO:0060322	head development	448	539	1.95e-09
GO:BP	GO:0032879	regulation of localization	1126	1439	1.96e-09
GO:BP	GO:0070848	response to growth factor	454	547	2.15e-09
GO:BP	GO:0016055	Wnt signaling pathway	307	358	2.17e-09
GO:BP	GO:0031344	regulation of cell projection organization	430	516	2.26e-09
GO:BP	GO:0001525	angiogenesis	325	381	2.26e-09
GO:BP	GO:0010647	positive regulation of cell communication	961	1218	2.40e-09
GO:BP	GO:0048729	tissue morphogenesis	381	453	2.59e-09
GO:BP	GO:0023056	positive regulation of signaling	963	1221	2.63e-09
GO:BP	GO:0051241	negative regulation of multicellular organismal process	575	706	3.23e-09
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	207	233	3.62e-09
GO:BP	GO:0007423	sensory organ development	329	387	3.96e-09
GO:BP	GO:0198738	cell-cell signaling by wnt	307	359	4.12e-09
GO:BP	GO:0001501	skeletal system development	297	347	6.89e-09
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	382	456	6.97e-09
GO:BP	GO:0007420	brain development	414	498	9.84e-09
GO:BP	GO:0071363	cellular response to growth factor stimulus	437	528	1.05e-08
GO:BP	GO:0051234	establishment of localization	2438	3240	1.13e-08
GO:BP	GO:0030111	regulation of Wnt signaling pathway	228	261	1.72e-08
GO:BP	GO:0050767	regulation of neurogenesis	251	290	1.77e-08
GO:BP	GO:0061448	connective tissue development	183	205	1.79e-08
GO:BP	GO:0034329	cell junction assembly	277	323	1.82e-08
GO:BP	GO:0070887	cellular response to chemical stimulus	1350	1751	2.34e-08
GO:BP	GO:0001667	ameboidal-type cell migration	293	344	2.79e-08
GO:BP	GO:0008015	blood circulation	303	357	3.22e-08
GO:BP	GO:0040013	negative regulation of locomotion	213	243	3.23e-08
GO:BP	GO:0061061	muscle structure development	441	536	4.28e-08
GO:BP	GO:0071310	cellular response to organic substance	1013	1297	4.30e-08
GO:BP	GO:0048584	positive regulation of response to stimulus	1166	1504	4.67e-08
GO:BP	GO:0016043	cellular component organization	3556	4802	4.67e-08
GO:BP	GO:0009967	positive regulation of signal transduction	861	1093	4.67e-08
GO:BP	GO:0048598	embryonic morphogenesis	353	422	4.79e-08
GO:BP	GO:0006897	endocytosis	407	492	4.79e-08
GO:BP	GO:0007507	heart development	412	499	6.15e-08
GO:BP	GO:0051216	cartilage development	133	145	6.15e-08
GO:BP	GO:0035265	organ growth	118	127	6.64e-08
GO:BP	GO:0030001	metal ion transport	431	524	6.85e-08
GO:BP	GO:0030029	actin filament-based process	519	640	9.17e-08
GO:BP	GO:0006468	protein phosphorylation	757	958	1.97e-07
GO:BP	GO:0030335	positive regulation of cell migration	330	395	2.27e-07
GO:BP	GO:2000147	positive regulation of cell motility	340	408	2.34e-07
GO:BP	GO:0048638	regulation of developmental growth	211	243	2.36e-07
GO:BP	GO:1901888	regulation of cell junction assembly	141	156	2.55e-07
GO:BP	GO:0060070	canonical Wnt signaling pathway	210	242	2.87e-07
GO:BP	GO:2000146	negative regulation of cell motility	190	217	3.19e-07
GO:BP	GO:0030336	negative regulation of cell migration	184	210	4.95e-07
GO:BP	GO:0099177	regulation of trans-synaptic signaling	273	323	5.14e-07
GO:BP	GO:0016310	phosphorylation	894	1145	5.17e-07
GO:BP	GO:0071417	cellular response to organonitrogen compound	365	442	5.21e-07
GO:BP	GO:0040017	positive regulation of locomotion	345	416	5.21e-07
GO:BP	GO:0043547	positive regulation of GTPase activity	105	113	5.34e-07
GO:BP	GO:0009790	embryo development	652	821	5.82e-07
GO:BP	GO:1903522	regulation of blood circulation	171	194	5.88e-07
GO:BP	GO:0050804	modulation of chemical synaptic transmission	272	322	5.89e-07
GO:BP	GO:0045664	regulation of neuron differentiation	119	130	6.08e-07
GO:BP	GO:0009987	cellular process	7680	10686	6.88e-07
GO:BP	GO:0042592	homeostatic process	887	1137	7.63e-07
GO:BP	GO:0016192	vesicle-mediated transport	898	1152	7.94e-07
GO:BP	GO:0060284	regulation of cell development	462	570	7.94e-07
GO:BP	GO:0002009	morphogenesis of an epithelium	308	369	8.32e-07
GO:BP	GO:0072073	kidney epithelium development	103	111	8.68e-07
GO:BP	GO:0044087	regulation of cellular component biogenesis	603	757	8.81e-07
GO:BP	GO:1902531	regulation of intracellular signal transduction	999	1289	9.23e-07
GO:BP	GO:0043087	regulation of GTPase activity	148	166	9.45e-07
GO:BP	GO:0007264	small GTPase-mediated signal transduction	324	390	9.49e-07
GO:BP	GO:0043010	camera-type eye development	199	230	1.11e-06
GO:BP	GO:0031589	cell-substrate adhesion	221	258	1.20e-06
GO:BP	GO:0051130	positive regulation of cellular component organization	672	850	1.22e-06
GO:BP	GO:0010243	response to organonitrogen compound	548	685	1.29e-06
GO:BP	GO:0048585	negative regulation of response to stimulus	927	1193	1.31e-06
GO:BP	GO:0090132	epithelium migration	209	243	1.39e-06
GO:BP	GO:0010631	epithelial cell migration	209	243	1.39e-06
GO:BP	GO:0048705	skeletal system morphogenesis	133	148	1.50e-06
GO:BP	GO:0001649	osteoblast differentiation	154	174	1.52e-06
GO:BP	GO:0090130	tissue migration	212	247	1.57e-06
GO:BP	GO:0014706	striated muscle tissue development	185	213	1.76e-06
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	177	203	1.85e-06
GO:BP	GO:0099537	trans-synaptic signaling	382	467	1.85e-06
GO:BP	GO:0050808	synapse organization	282	337	1.90e-06
GO:BP	GO:0099536	synaptic signaling	394	483	2.08e-06
GO:BP	GO:0040007	growth	556	697	2.08e-06
GO:BP	GO:0023057	negative regulation of signaling	809	1036	2.33e-06
GO:BP	GO:0045165	cell fate commitment	135	151	2.47e-06
GO:BP	GO:0001654	eye development	224	263	2.50e-06
GO:BP	GO:0031214	biomineral tissue development	98	106	2.95e-06
GO:BP	GO:0065009	regulation of molecular function	1003	1299	2.95e-06
GO:BP	GO:0007268	chemical synaptic transmission	378	463	3.20e-06
GO:BP	GO:0098916	anterograde trans-synaptic signaling	378	463	3.20e-06
GO:BP	GO:0048880	sensory system development	226	266	3.30e-06
GO:BP	GO:0021537	telencephalon development	170	195	3.35e-06
GO:BP	GO:0008016	regulation of heart contraction	146	165	3.38e-06
GO:BP	GO:0060560	developmental growth involved in morphogenesis	166	190	3.38e-06
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	240	284	3.39e-06
GO:BP	GO:1901652	response to peptide	305	368	3.54e-06
GO:BP	GO:0030036	actin cytoskeleton organization	456	566	3.61e-06
GO:BP	GO:0030855	epithelial cell differentiation	351	428	3.63e-06
GO:BP	GO:1901700	response to oxygen-containing compound	850	1093	3.66e-06
GO:BP	GO:0009893	positive regulation of metabolic process	1968	2622	3.98e-06
GO:BP	GO:0010648	negative regulation of cell communication	806	1034	4.01e-06
GO:BP	GO:0003007	heart morphogenesis	188	218	4.02e-06
GO:BP	GO:0048871	multicellular organismal-level homeostasis	433	536	4.09e-06
GO:BP	GO:0003206	cardiac chamber morphogenesis	101	110	4.40e-06
GO:BP	GO:0150063	visual system development	224	264	4.48e-06
GO:BP	GO:0010720	positive regulation of cell development	259	309	4.57e-06
GO:BP	GO:0030278	regulation of ossification	75	79	4.77e-06
GO:BP	GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	220	259	4.77e-06
GO:BP	GO:0010632	regulation of epithelial cell migration	164	188	4.82e-06
GO:BP	GO:0090596	sensory organ morphogenesis	152	173	4.96e-06
GO:BP	GO:0010033	response to organic substance	1322	1736	5.17e-06
GO:BP	GO:1901698	response to nitrogen compound	583	736	5.60e-06
GO:BP	GO:0098660	inorganic ion transmembrane transport	421	521	5.60e-06
GO:BP	GO:0009968	negative regulation of signal transduction	759	972	5.63e-06
GO:BP	GO:0044093	positive regulation of molecular function	618	783	6.01e-06
GO:BP	GO:0006811	monoatomic ion transport	570	719	6.22e-06
GO:BP	GO:0050770	regulation of axonogenesis	113	125	6.45e-06
GO:BP	GO:0006812	monoatomic cation transport	491	614	6.45e-06
GO:BP	GO:0003205	cardiac chamber development	134	151	7.05e-06
GO:BP	GO:0048639	positive regulation of developmental growth	108	119	7.29e-06
GO:BP	GO:0071840	cellular component organization or biogenesis	3665	4988	7.88e-06
GO:BP	GO:0048771	tissue remodeling	103	113	8.09e-06
GO:BP	GO:0008150	biological_process	8053	11244	8.24e-06
GO:BP	GO:0098662	inorganic cation transmembrane transport	389	480	8.92e-06
GO:BP	GO:0031401	positive regulation of protein modification process	442	550	9.09e-06
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	376	463	9.22e-06
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	376	463	9.22e-06
GO:BP	GO:0060047	heart contraction	168	194	9.64e-06
GO:BP	GO:1901699	cellular response to nitrogen compound	388	479	1.01e-05
GO:BP	GO:0007186	G protein-coupled receptor signaling pathway	317	386	1.06e-05
GO:BP	GO:0034220	monoatomic ion transmembrane transport	469	587	1.45e-05
GO:BP	GO:0007010	cytoskeleton organization	885	1146	1.58e-05
GO:BP	GO:0048738	cardiac muscle tissue development	173	201	1.58e-05
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	184	215	1.61e-05
GO:BP	GO:0097485	neuron projection guidance	150	172	1.61e-05
GO:BP	GO:0007411	axon guidance	150	172	1.61e-05
GO:BP	GO:0043434	response to peptide hormone	261	314	1.62e-05
GO:BP	GO:0035108	limb morphogenesis	100	110	1.62e-05
GO:BP	GO:0035107	appendage morphogenesis	100	110	1.62e-05
GO:BP	GO:0043062	extracellular structure organization	191	224	1.66e-05
GO:BP	GO:0045229	external encapsulating structure organization	191	224	1.66e-05
GO:BP	GO:0060627	regulation of vesicle-mediated transport	307	374	1.72e-05
GO:BP	GO:0071559	response to transforming growth factor beta	187	219	1.76e-05
GO:BP	GO:0003231	cardiac ventricle development	104	115	1.79e-05
GO:BP	GO:0050673	epithelial cell proliferation	250	300	1.81e-05
GO:BP	GO:0097435	supramolecular fiber organization	503	633	1.84e-05
GO:BP	GO:0060411	cardiac septum morphogenesis	64	67	1.93e-05
GO:BP	GO:0030198	extracellular matrix organization	190	223	1.95e-05
GO:BP	GO:0050877	nervous system process	478	600	2.01e-05
GO:BP	GO:0007389	pattern specification process	239	286	2.02e-05
GO:BP	GO:0003015	heart process	175	204	2.07e-05
GO:BP	GO:0048568	embryonic organ development	252	303	2.23e-05
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	120	135	2.28e-05
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	1810	2415	2.60e-05
GO:BP	GO:0030010	establishment of cell polarity	111	124	2.60e-05
GO:BP	GO:0048588	developmental cell growth	155	179	2.61e-05
GO:BP	GO:0007160	cell-matrix adhesion	147	169	2.79e-05
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	209	248	2.92e-05
GO:BP	GO:0098655	monoatomic cation transmembrane transport	398	495	3.00e-05
GO:BP	GO:0060562	epithelial tube morphogenesis	219	261	3.14e-05
GO:BP	GO:0048592	eye morphogenesis	97	107	3.16e-05
GO:BP	GO:0035023	regulation of Rho protein signal transduction	62	65	3.31e-05
GO:BP	GO:0044089	positive regulation of cellular component biogenesis	318	390	3.48e-05
GO:BP	GO:0022407	regulation of cell-cell adhesion	232	278	3.53e-05
GO:BP	GO:0008283	cell population proliferation	1000	1306	3.75e-05
GO:BP	GO:0042391	regulation of membrane potential	235	282	3.76e-05
GO:BP	GO:0090257	regulation of muscle system process	153	177	3.77e-05
GO:BP	GO:0043408	regulation of MAPK cascade	346	427	3.77e-05
GO:BP	GO:1901701	cellular response to oxygen-containing compound	623	796	3.90e-05
GO:BP	GO:0006793	phosphorus metabolic process	1437	1904	3.96e-05
GO:BP	GO:0048762	mesenchymal cell differentiation	171	200	4.20e-05
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	76	82	5.49e-05
GO:BP	GO:0042330	taxis	205	244	5.62e-05
GO:BP	GO:0006935	chemotaxis	205	244	5.62e-05
GO:BP	GO:0045785	positive regulation of cell adhesion	249	301	5.82e-05
GO:BP	GO:0072006	nephron development	103	115	5.86e-05
GO:BP	GO:0006796	phosphate-containing compound metabolic process	1420	1883	6.23e-05
GO:BP	GO:0060537	muscle tissue development	278	339	6.40e-05
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	1640	2186	6.55e-05
GO:BP	GO:0031399	regulation of protein modification process	707	911	6.56e-05
GO:BP	GO:0003281	ventricular septum development	65	69	6.56e-05
GO:BP	GO:0030326	embryonic limb morphogenesis	80	87	6.61e-05
GO:BP	GO:0035113	embryonic appendage morphogenesis	80	87	6.61e-05
GO:BP	GO:0045667	regulation of osteoblast differentiation	89	98	7.03e-05
GO:BP	GO:0070167	regulation of biomineral tissue development	59	62	7.48e-05
GO:BP	GO:0042127	regulation of cell population proliferation	829	1077	8.19e-05
GO:BP	GO:0034762	regulation of transmembrane transport	246	298	9.01e-05
GO:BP	GO:0001823	mesonephros development	69	74	9.01e-05
GO:BP	GO:0051247	positive regulation of protein metabolic process	706	911	9.37e-05
GO:BP	GO:0031325	positive regulation of cellular metabolic process	1745	2333	9.39e-05
GO:BP	GO:0046903	secretion	491	622	9.45e-05
GO:BP	GO:0060485	mesenchyme development	205	245	9.67e-05
GO:BP	GO:0003279	cardiac septum development	92	102	9.77e-05
GO:BP	GO:0007159	leukocyte cell-cell adhesion	184	218	9.81e-05
GO:BP	GO:0032835	glomerulus development	52	54	1.02e-04
GO:BP	GO:0042327	positive regulation of phosphorylation	335	415	1.03e-04
GO:BP	GO:0051174	regulation of phosphorus metabolic process	627	805	1.08e-04
GO:BP	GO:0055123	digestive system development	87	96	1.11e-04
GO:BP	GO:0072163	mesonephric epithelium development	68	73	1.14e-04
GO:BP	GO:0072164	mesonephric tubule development	68	73	1.14e-04
GO:BP	GO:0000165	MAPK cascade	402	504	1.14e-04
GO:BP	GO:0019220	regulation of phosphate metabolic process	626	804	1.18e-04
GO:BP	GO:0051962	positive regulation of nervous system development	179	212	1.25e-04
GO:BP	GO:0051129	negative regulation of cellular component organization	440	555	1.32e-04
GO:BP	GO:0003012	muscle system process	266	325	1.35e-04
GO:BP	GO:0150115	cell-substrate junction organization	86	95	1.39e-04
GO:BP	GO:0030282	bone mineralization	72	78	1.44e-04
GO:BP	GO:0140352	export from cell	469	594	1.45e-04
GO:BP	GO:0001657	ureteric bud development	67	72	1.46e-04
GO:BP	GO:0007610	behavior	338	420	1.53e-04
GO:BP	GO:0007163	establishment or maintenance of cell polarity	156	183	1.62e-04
GO:BP	GO:0014855	striated muscle cell proliferation	56	59	1.66e-04
GO:BP	GO:0001763	morphogenesis of a branching structure	126	145	1.68e-04
GO:BP	GO:0010463	mesenchymal cell proliferation	36	36	1.79e-04
GO:BP	GO:0051336	regulation of hydrolase activity	346	431	1.79e-04
GO:BP	GO:0050807	regulation of synapse organization	148	173	1.83e-04
GO:BP	GO:0030100	regulation of endocytosis	166	196	1.84e-04
GO:BP	GO:0007517	muscle organ development	221	267	1.84e-04
GO:BP	GO:0003002	regionalization	214	258	1.92e-04
GO:BP	GO:0048565	digestive tract development	80	88	1.94e-04
GO:BP	GO:0007259	receptor signaling pathway via JAK-STAT	80	88	1.94e-04
GO:BP	GO:0007044	cell-substrate junction assembly	80	88	1.94e-04
GO:BP	GO:0048167	regulation of synaptic plasticity	121	139	2.06e-04
GO:BP	GO:0051961	negative regulation of nervous system development	97	109	2.06e-04
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	97	109	2.06e-04
GO:BP	GO:0009605	response to external stimulus	1179	1559	2.07e-04
GO:BP	GO:1990138	neuron projection extension	117	134	2.10e-04
GO:BP	GO:0001764	neuron migration	113	129	2.13e-04
GO:BP	GO:0043085	positive regulation of catalytic activity	432	546	2.23e-04
GO:BP	GO:0001934	positive regulation of protein phosphorylation	319	396	2.28e-04
GO:BP	GO:0055017	cardiac muscle tissue growth	60	64	2.33e-04
GO:BP	GO:0046622	positive regulation of organ growth	35	35	2.39e-04
GO:BP	GO:0050803	regulation of synapse structure or activity	150	176	2.39e-04
GO:BP	GO:0048593	camera-type eye morphogenesis	79	87	2.41e-04
GO:BP	GO:0050768	negative regulation of neurogenesis	92	103	2.42e-04
GO:BP	GO:0007162	negative regulation of cell adhesion	157	185	2.46e-04
GO:BP	GO:0051641	cellular localization	1950	2623	2.46e-04
GO:BP	GO:0043269	regulation of monoatomic ion transport	232	282	2.48e-04
GO:BP	GO:0050920	regulation of chemotaxis	116	133	2.51e-04
GO:BP	GO:0031346	positive regulation of cell projection organization	235	286	2.58e-04
GO:BP	GO:0033002	muscle cell proliferation	131	152	2.62e-04
GO:BP	GO:1901653	cellular response to peptide	225	273	2.62e-04
GO:BP	GO:0045666	positive regulation of neuron differentiation	54	57	2.73e-04
GO:BP	GO:0055085	transmembrane transport	710	921	2.77e-04
GO:BP	GO:0042063	gliogenesis	201	242	2.88e-04
GO:BP	GO:0050769	positive regulation of neurogenesis	156	184	2.88e-04
GO:BP	GO:0061035	regulation of cartilage development	48	50	2.96e-04
GO:BP	GO:0007229	integrin-mediated signaling pathway	78	86	2.97e-04
GO:BP	GO:0009725	response to hormone	479	610	3.10e-04
GO:BP	GO:0016331	morphogenesis of embryonic epithelium	107	122	3.12e-04
GO:BP	GO:0032330	regulation of chondrocyte differentiation	34	34	3.19e-04
GO:BP	GO:0097696	receptor signaling pathway via STAT	82	91	3.25e-04
GO:BP	GO:0016358	dendrite development	155	183	3.40e-04
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	176	210	3.40e-04
GO:BP	GO:0050678	regulation of epithelial cell proliferation	206	249	3.70e-04
GO:BP	GO:0060993	kidney morphogenesis	63	68	3.81e-04
GO:BP	GO:0032970	regulation of actin filament-based process	245	300	3.88e-04
GO:BP	GO:0010721	negative regulation of cell development	154	182	4.03e-04
GO:BP	GO:0001952	regulation of cell-matrix adhesion	81	90	4.08e-04
GO:BP	GO:0061138	morphogenesis of a branching epithelium	117	135	4.31e-04
GO:BP	GO:0032940	secretion by cell	434	551	4.55e-04
GO:BP	GO:0051057	positive regulation of small GTPase mediated signal transduction	52	55	4.65e-04
GO:BP	GO:0007015	actin filament organization	288	357	4.70e-04
GO:BP	GO:0072009	nephron epithelium development	76	84	4.70e-04
GO:BP	GO:0001656	metanephros development	57	61	4.93e-04
GO:BP	GO:0042325	regulation of phosphorylation	532	683	5.17e-04
GO:BP	GO:0030500	regulation of bone mineralization	46	48	5.17e-04
GO:BP	GO:0003018	vascular process in circulatory system	163	194	5.18e-04
GO:BP	GO:0007179	transforming growth factor beta receptor signaling pathway	145	171	5.55e-04
GO:BP	GO:1901342	regulation of vasculature development	166	198	5.59e-04
GO:BP	GO:0021953	central nervous system neuron differentiation	88	99	5.59e-04
GO:BP	GO:0007266	Rho protein signal transduction	96	109	5.76e-04
GO:BP	GO:0001775	cell activation	490	627	5.92e-04
GO:BP	GO:0045216	cell-cell junction organization	130	152	6.10e-04
GO:BP	GO:0031032	actomyosin structure organization	155	184	6.10e-04
GO:BP	GO:1902893	regulation of miRNA transcription	56	60	6.33e-04
GO:BP	GO:0018105	peptidyl-serine phosphorylation	137	161	6.34e-04
GO:BP	GO:0002521	leukocyte differentiation	298	371	6.34e-04
GO:BP	GO:1903037	regulation of leukocyte cell-cell adhesion	165	197	6.49e-04
GO:BP	GO:0060412	ventricular septum morphogenesis	39	40	6.49e-04
GO:BP	GO:0051050	positive regulation of transport	448	571	6.53e-04
GO:BP	GO:0048041	focal adhesion assembly	70	77	6.59e-04
GO:BP	GO:0021987	cerebral cortex development	83	93	6.59e-04
GO:BP	GO:0006816	calcium ion transport	215	262	6.66e-04
GO:BP	GO:0051345	positive regulation of hydrolase activity	218	266	6.91e-04
GO:BP	GO:0043542	endothelial cell migration	147	174	7.07e-04
GO:BP	GO:0043583	ear development	129	151	7.16e-04
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	554	714	7.24e-04
GO:BP	GO:0060419	heart growth	65	71	7.27e-04
GO:BP	GO:0018209	peptidyl-serine modification	143	169	7.61e-04
GO:BP	GO:0060043	regulation of cardiac muscle cell proliferation	31	31	8.05e-04
GO:BP	GO:0018212	peptidyl-tyrosine modification	139	164	8.23e-04
GO:BP	GO:0006898	receptor-mediated endocytosis	153	182	8.31e-04
GO:BP	GO:0010959	regulation of metal ion transport	197	239	8.31e-04
GO:BP	GO:0098771	inorganic ion homeostasis	280	348	8.43e-04
GO:BP	GO:0010594	regulation of endothelial cell migration	117	136	8.45e-04
GO:BP	GO:0032870	cellular response to hormone stimulus	344	433	8.75e-04
GO:BP	GO:0046620	regulation of organ growth	64	70	9.22e-04
GO:BP	GO:0043068	positive regulation of programmed cell death	310	388	9.34e-04
GO:BP	GO:0050772	positive regulation of axonogenesis	59	64	1.00e-03
GO:BP	GO:0048645	animal organ formation	49	52	1.00e-03
GO:BP	GO:0021543	pallium development	116	135	1.02e-03
GO:BP	GO:0045765	regulation of angiogenesis	162	194	1.03e-03
GO:BP	GO:0090066	regulation of anatomical structure size	303	379	1.03e-03
GO:BP	GO:0043410	positive regulation of MAPK cascade	234	288	1.08e-03
GO:BP	GO:0098900	regulation of action potential	37	38	1.15e-03
GO:BP	GO:0010810	regulation of cell-substrate adhesion	137	162	1.15e-03
GO:BP	GO:0018108	peptidyl-tyrosine phosphorylation	137	162	1.15e-03
GO:BP	GO:0061005	cell differentiation involved in kidney development	37	38	1.15e-03
GO:BP	GO:0010717	regulation of epithelial to mesenchymal transition	76	85	1.20e-03
GO:BP	GO:0022604	regulation of cell morphogenesis	161	193	1.20e-03
GO:BP	GO:0032409	regulation of transporter activity	126	148	1.20e-03
GO:BP	GO:0030177	positive regulation of Wnt signaling pathway	96	110	1.23e-03
GO:BP	GO:0043588	skin development	147	175	1.24e-03
GO:BP	GO:0001932	regulation of protein phosphorylation	499	642	1.27e-03
GO:BP	GO:0070588	calcium ion transmembrane transport	174	210	1.29e-03
GO:BP	GO:0010633	negative regulation of epithelial cell migration	48	51	1.29e-03
GO:BP	GO:0061326	renal tubule development	67	74	1.29e-03
GO:BP	GO:0021954	central nervous system neuron development	53	57	1.31e-03
GO:BP	GO:0035148	tube formation	107	124	1.33e-03
GO:BP	GO:0061351	neural precursor cell proliferation	103	119	1.39e-03
GO:BP	GO:0071375	cellular response to peptide hormone stimulus	190	231	1.39e-03
GO:BP	GO:0042692	muscle cell differentiation	260	323	1.43e-03
GO:BP	GO:0051246	regulation of protein metabolic process	1197	1595	1.44e-03
GO:BP	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	29	29	1.47e-03
GO:BP	GO:0044409	symbiont entry into host	95	109	1.48e-03
GO:BP	GO:0055021	regulation of cardiac muscle tissue growth	42	44	1.49e-03
GO:BP	GO:0008284	positive regulation of cell population proliferation	471	605	1.52e-03
GO:BP	GO:0006814	sodium ion transport	117	137	1.61e-03
GO:BP	GO:0071772	response to BMP	102	118	1.67e-03
GO:BP	GO:0060348	bone development	124	146	1.67e-03
GO:BP	GO:0048008	platelet-derived growth factor receptor signaling pathway	47	50	1.67e-03
GO:BP	GO:0071773	cellular response to BMP stimulus	102	118	1.67e-03
GO:BP	GO:0050900	leukocyte migration	162	195	1.70e-03
GO:BP	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	98	113	1.73e-03
GO:BP	GO:1901343	negative regulation of vasculature development	61	67	1.82e-03
GO:BP	GO:2000181	negative regulation of blood vessel morphogenesis	61	67	1.82e-03
GO:BP	GO:0003151	outflow tract morphogenesis	61	67	1.82e-03
GO:BP	GO:0022612	gland morphogenesis	82	93	1.87e-03
GO:BP	GO:0007416	synapse assembly	116	136	1.91e-03
GO:BP	GO:0045665	negative regulation of neuron differentiation	41	43	1.95e-03
GO:BP	GO:0060038	cardiac muscle cell proliferation	41	43	1.95e-03
GO:BP	GO:0008285	negative regulation of cell population proliferation	369	469	1.98e-03
GO:BP	GO:0060421	positive regulation of heart growth	28	28	1.99e-03
GO:BP	GO:0072175	epithelial tube formation	101	117	1.99e-03
GO:BP	GO:2000628	regulation of miRNA metabolic process	65	72	1.99e-03
GO:BP	GO:0061614	miRNA transcription	56	61	1.99e-03
GO:BP	GO:0060420	regulation of heart growth	46	49	2.11e-03
GO:BP	GO:0090109	regulation of cell-substrate junction assembly	51	55	2.11e-03
GO:BP	GO:1903053	regulation of extracellular matrix organization	46	49	2.11e-03
GO:BP	GO:0051893	regulation of focal adhesion assembly	51	55	2.11e-03
GO:BP	GO:0030048	actin filament-based movement	93	107	2.14e-03
GO:BP	GO:0030097	hemopoiesis	484	624	2.20e-03
GO:BP	GO:1903131	mononuclear cell differentiation	225	278	2.21e-03
GO:BP	GO:0110020	regulation of actomyosin structure organization	77	87	2.24e-03
GO:BP	GO:0010586	miRNA metabolic process	77	87	2.24e-03
GO:BP	GO:0043065	positive regulation of apoptotic process	302	380	2.24e-03
GO:BP	GO:0016525	negative regulation of angiogenesis	60	66	2.25e-03
GO:BP	GO:0060541	respiratory system development	136	162	2.30e-03
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	173	210	2.34e-03
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	156	188	2.47e-03
GO:BP	GO:0022898	regulation of transmembrane transporter activity	118	139	2.47e-03
GO:BP	GO:0050790	regulation of catalytic activity	682	893	2.49e-03
GO:BP	GO:0150116	regulation of cell-substrate junction organization	55	60	2.49e-03
GO:BP	GO:0002064	epithelial cell development	125	148	2.49e-03
GO:BP	GO:0071407	cellular response to organic cyclic compound	301	379	2.49e-03
GO:BP	GO:0008360	regulation of cell shape	92	106	2.55e-03
GO:BP	GO:0051963	regulation of synapse assembly	68	76	2.59e-03
GO:BP	GO:1901890	positive regulation of cell junction assembly	68	76	2.59e-03
GO:BP	GO:0045663	positive regulation of myoblast differentiation	34	35	2.59e-03
GO:BP	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	114	134	2.62e-03
GO:BP	GO:0098901	regulation of cardiac muscle cell action potential	27	27	2.64e-03
GO:BP	GO:0010464	regulation of mesenchymal cell proliferation	27	27	2.64e-03
GO:BP	GO:0006942	regulation of striated muscle contraction	72	81	2.66e-03
GO:BP	GO:0010976	positive regulation of neuron projection development	110	129	2.79e-03
GO:BP	GO:0055117	regulation of cardiac muscle contraction	59	65	2.79e-03
GO:BP	GO:0008361	regulation of cell size	124	147	2.92e-03
GO:BP	GO:0030509	BMP signaling pathway	95	110	2.94e-03
GO:BP	GO:0072080	nephron tubule development	63	70	3.04e-03
GO:BP	GO:0046849	bone remodeling	54	59	3.14e-03
GO:BP	GO:0071695	anatomical structure maturation	127	151	3.16e-03
GO:BP	GO:0032101	regulation of response to external stimulus	505	654	3.25e-03
GO:BP	GO:0060840	artery development	75	85	3.32e-03
GO:BP	GO:0061337	cardiac conduction	75	85	3.32e-03
GO:BP	GO:0033135	regulation of peptidyl-serine phosphorylation	75	85	3.32e-03
GO:BP	GO:1903039	positive regulation of leukocyte cell-cell adhesion	123	146	3.43e-03
GO:BP	GO:0061572	actin filament bundle organization	112	132	3.69e-03
GO:BP	GO:0036211	protein modification process	1696	2291	3.69e-03
GO:BP	GO:0014013	regulation of gliogenesis	62	69	3.80e-03
GO:BP	GO:0043270	positive regulation of monoatomic ion transport	108	127	3.95e-03
GO:BP	GO:0061333	renal tubule morphogenesis	53	58	3.95e-03
GO:BP	GO:0072028	nephron morphogenesis	53	58	3.95e-03
GO:BP	GO:0048864	stem cell development	66	74	3.95e-03
GO:BP	GO:0010634	positive regulation of epithelial cell migration	108	127	3.95e-03
GO:BP	GO:0014897	striated muscle hypertrophy	66	74	3.95e-03
GO:BP	GO:0098727	maintenance of cell number	122	145	4.00e-03
GO:BP	GO:0031345	negative regulation of cell projection organization	122	145	4.00e-03
GO:BP	GO:0031623	receptor internalization	78	89	4.00e-03
GO:BP	GO:0060173	limb development	115	136	4.00e-03
GO:BP	GO:0048736	appendage development	115	136	4.00e-03
GO:BP	GO:0042476	odontogenesis	70	79	4.00e-03
GO:BP	GO:0048878	chemical homeostasis	516	670	4.18e-03
GO:BP	GO:0000003	reproduction	672	882	4.19e-03
GO:BP	GO:0045669	positive regulation of osteoblast differentiation	48	52	4.27e-03
GO:BP	GO:0051017	actin filament bundle assembly	111	131	4.30e-03
GO:BP	GO:0046718	symbiont entry into host cell	89	103	4.40e-03
GO:BP	GO:0060350	endochondral bone morphogenesis	43	46	4.41e-03
GO:BP	GO:0006937	regulation of muscle contraction	107	126	4.64e-03
GO:BP	GO:0030324	lung development	121	144	4.68e-03
GO:BP	GO:0031099	regeneration	121	144	4.68e-03
GO:BP	GO:0003300	cardiac muscle hypertrophy	65	73	4.84e-03
GO:BP	GO:0060349	bone morphogenesis	65	73	4.84e-03
GO:BP	GO:0055023	positive regulation of cardiac muscle tissue growth	25	25	4.84e-03
GO:BP	GO:0055006	cardiac cell development	69	78	4.91e-03
GO:BP	GO:0050890	cognition	174	213	4.91e-03
GO:BP	GO:0030323	respiratory tube development	124	148	5.02e-03
GO:BP	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	127	152	5.40e-03
GO:BP	GO:0042733	embryonic digit morphogenesis	47	51	5.44e-03
GO:BP	GO:0003208	cardiac ventricle morphogenesis	56	62	5.44e-03
GO:BP	GO:0045778	positive regulation of ossification	37	39	5.46e-03
GO:BP	GO:0019827	stem cell population maintenance	120	143	5.48e-03
GO:BP	GO:0040008	regulation of growth	361	462	5.58e-03
GO:BP	GO:0042981	regulation of apoptotic process	780	1031	5.58e-03
GO:BP	GO:0023061	signal release	251	315	5.62e-03
GO:BP	GO:0010628	positive regulation of gene expression	571	746	5.64e-03
GO:BP	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	80	92	5.70e-03
GO:BP	GO:0071805	potassium ion transmembrane transport	102	120	5.86e-03
GO:BP	GO:0086004	regulation of cardiac muscle cell contraction	31	32	5.94e-03
GO:BP	GO:0001838	embryonic epithelial tube formation	91	106	5.94e-03
GO:BP	GO:0035850	epithelial cell differentiation involved in kidney development	31	32	5.94e-03
GO:BP	GO:0007043	cell-cell junction assembly	91	106	5.94e-03
GO:BP	GO:0014033	neural crest cell differentiation	68	77	5.96e-03
GO:BP	GO:0072088	nephron epithelium morphogenesis	51	56	6.14e-03
GO:BP	GO:0048708	astrocyte differentiation	51	56	6.14e-03
GO:BP	GO:0010817	regulation of hormone levels	253	318	6.26e-03
GO:BP	GO:0003006	developmental process involved in reproduction	443	573	6.28e-03
GO:BP	GO:0001894	tissue homeostasis	136	164	6.30e-03
GO:BP	GO:0060249	anatomical structure homeostasis	136	164	6.30e-03
GO:BP	GO:0046777	protein autophosphorylation	119	142	6.32e-03
GO:BP	GO:0048839	inner ear development	112	133	6.38e-03
GO:BP	GO:0071875	adrenergic receptor signaling pathway	24	24	6.47e-03
GO:BP	GO:0098868	bone growth	24	24	6.47e-03
GO:BP	GO:0010001	glial cell differentiation	149	181	6.53e-03
GO:BP	GO:0048469	cell maturation	94	110	6.60e-03
GO:BP	GO:0031016	pancreas development	46	50	6.74e-03
GO:BP	GO:2000630	positive regulation of miRNA metabolic process	46	50	6.74e-03
GO:BP	GO:0030038	contractile actin filament bundle assembly	79	91	6.76e-03
GO:BP	GO:0043149	stress fiber assembly	79	91	6.76e-03
GO:BP	GO:0007272	ensheathment of neurons	101	119	6.78e-03
GO:BP	GO:0008366	axon ensheathment	101	119	6.78e-03
GO:BP	GO:0001837	epithelial to mesenchymal transition	115	137	6.81e-03
GO:BP	GO:0010596	negative regulation of endothelial cell migration	36	38	6.91e-03
GO:BP	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	75	86	6.95e-03
GO:BP	GO:0060041	retina development in camera-type eye	90	105	6.95e-03
GO:BP	GO:1902895	positive regulation of miRNA transcription	41	44	7.04e-03
GO:BP	GO:0034103	regulation of tissue remodeling	41	44	7.04e-03
GO:BP	GO:0022414	reproductive process	664	874	7.20e-03
GO:BP	GO:0043067	regulation of programmed cell death	800	1060	7.23e-03
GO:BP	GO:0060341	regulation of cellular localization	592	776	7.41e-03
GO:BP	GO:0003179	heart valve morphogenesis	50	55	7.57e-03
GO:BP	GO:0048732	gland development	245	308	7.60e-03
GO:BP	GO:0021955	central nervous system neuron axonogenesis	30	31	7.69e-03
GO:BP	GO:0035725	sodium ion transmembrane transport	82	95	7.72e-03
GO:BP	GO:0010977	negative regulation of neuron projection development	93	109	7.74e-03
GO:BP	GO:0061458	reproductive system development	167	205	7.87e-03
GO:BP	GO:0008544	epidermis development	170	209	8.09e-03
GO:BP	GO:0021675	nerve development	54	60	8.17e-03
GO:BP	GO:1990778	protein localization to cell periphery	229	287	8.29e-03
GO:BP	GO:0032231	regulation of actin filament bundle assembly	74	85	8.37e-03
GO:BP	GO:0007369	gastrulation	117	140	8.48e-03
GO:BP	GO:0003170	heart valve development	58	65	8.52e-03
GO:BP	GO:0060291	long-term synaptic potentiation	58	65	8.52e-03
GO:BP	GO:0048754	branching morphogenesis of an epithelial tube	96	113	8.54e-03
GO:BP	GO:0051924	regulation of calcium ion transport	127	153	8.56e-03
GO:BP	GO:0061036	positive regulation of cartilage development	23	23	8.56e-03
GO:BP	GO:0003416	endochondral bone growth	23	23	8.56e-03
GO:BP	GO:0002685	regulation of leukocyte migration	103	122	8.56e-03
GO:BP	GO:0002063	chondrocyte development	23	23	8.56e-03
GO:BP	GO:0060037	pharyngeal system development	23	23	8.56e-03
GO:BP	GO:0097553	calcium ion transmembrane import into cytosol	103	122	8.56e-03
GO:BP	GO:0014896	muscle hypertrophy	66	75	8.57e-03
GO:BP	GO:0090288	negative regulation of cellular response to growth factor stimulus	66	75	8.57e-03
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	1366	1841	8.68e-03
GO:BP	GO:1903115	regulation of actin filament-based movement	35	37	8.77e-03
GO:BP	GO:0002090	regulation of receptor internalization	40	43	8.85e-03
GO:BP	GO:0045321	leukocyte activation	410	530	8.87e-03
GO:BP	GO:0006813	potassium ion transport	113	135	9.08e-03
GO:BP	GO:0050870	positive regulation of T cell activation	113	135	9.08e-03
GO:BP	GO:0051051	negative regulation of transport	228	286	9.08e-03
GO:BP	GO:0042552	myelination	99	117	9.19e-03
GO:BP	GO:0014910	regulation of smooth muscle cell migration	49	54	9.22e-03
GO:BP	GO:0072078	nephron tubule morphogenesis	49	54	9.22e-03
GO:BP	GO:0042475	odontogenesis of dentin-containing tooth	49	54	9.22e-03
GO:BP	GO:0055074	calcium ion homeostasis	175	216	9.37e-03
GO:BP	GO:0030098	lymphocyte differentiation	200	249	9.41e-03
GO:BP	GO:0001659	temperature homeostasis	109	130	9.82e-03
GO:BP	GO:0009612	response to mechanical stimulus	126	152	9.82e-03
GO:BP	GO:0035270	endocrine system development	73	84	9.82e-03
GO:BP	GO:0034764	positive regulation of transmembrane transport	109	130	9.82e-03
GO:BP	GO:0048562	embryonic organ morphogenesis	149	182	9.82e-03
GO:BP	GO:0048546	digestive tract morphogenesis	29	30	9.82e-03
GO:BP	GO:0046850	regulation of bone remodeling	29	30	9.82e-03
GO:BP	GO:0021700	developmental maturation	165	203	9.84e-03
GO:BP	GO:1990845	adaptive thermogenesis	102	121	9.84e-03
GO:BP	GO:0009952	anterior/posterior pattern specification	102	121	9.84e-03
GO:BP	GO:0050867	positive regulation of cell activation	165	203	9.84e-03
GO:BP	GO:0007346	regulation of mitotic cell cycle	328	420	9.87e-03
GO:BP	GO:0009891	positive regulation of biosynthetic process	1376	1856	9.87e-03
GO:BP	GO:0048259	regulation of receptor-mediated endocytosis	69	79	1.00e-02
GO:BP	GO:0050680	negative regulation of epithelial cell proliferation	84	98	1.00e-02
GO:BP	GO:0030031	cell projection assembly	348	447	1.01e-02
GO:BP	GO:0042110	T cell activation	242	305	1.01e-02
GO:BP	GO:0048644	muscle organ morphogenesis	57	64	1.01e-02
GO:BP	GO:0010718	positive regulation of epithelial to mesenchymal transition	44	48	1.02e-02
GO:BP	GO:0014032	neural crest cell development	61	69	1.02e-02
GO:BP	GO:0001755	neural crest cell migration	44	48	1.02e-02
GO:BP	GO:0071396	cellular response to lipid	304	388	1.04e-02
GO:BP	GO:0060048	cardiac muscle contraction	98	116	1.05e-02
GO:BP	GO:0099173	postsynapse organization	122	147	1.05e-02
GO:BP	GO:0045598	regulation of fat cell differentiation	80	93	1.05e-02
GO:BP	GO:0033043	regulation of organelle organization	720	953	1.07e-02
GO:BP	GO:0032880	regulation of protein localization	528	691	1.08e-02
GO:BP	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	115	138	1.09e-02
GO:BP	GO:0031641	regulation of myelination	34	36	1.10e-02
GO:BP	GO:0003203	endocardial cushion morphogenesis	34	36	1.10e-02
GO:BP	GO:0048608	reproductive structure development	164	202	1.10e-02
GO:BP	GO:0033036	macromolecule localization	1702	2309	1.10e-02
GO:BP	GO:0006874	intracellular calcium ion homeostasis	164	202	1.10e-02
GO:BP	GO:0003177	pulmonary valve development	22	22	1.11e-02
GO:BP	GO:0060045	positive regulation of cardiac muscle cell proliferation	22	22	1.11e-02
GO:BP	GO:0050921	positive regulation of chemotaxis	72	83	1.15e-02
GO:BP	GO:0050679	positive regulation of epithelial cell proliferation	118	142	1.15e-02
GO:BP	GO:0007611	learning or memory	154	189	1.16e-02
GO:BP	GO:0051235	maintenance of location	201	251	1.16e-02
GO:BP	GO:0006936	muscle contraction	204	255	1.17e-02
GO:BP	GO:0002028	regulation of sodium ion transport	52	58	1.18e-02
GO:BP	GO:0033138	positive regulation of peptidyl-serine phosphorylation	52	58	1.18e-02
GO:BP	GO:0021915	neural tube development	111	133	1.18e-02
GO:BP	GO:0045661	regulation of myoblast differentiation	52	58	1.18e-02
GO:BP	GO:0050865	regulation of cell activation	273	347	1.19e-02
GO:BP	GO:0002696	positive regulation of leukocyte activation	160	197	1.21e-02
GO:BP	GO:0120031	plasma membrane bounded cell projection assembly	340	437	1.21e-02
GO:BP	GO:0007492	endoderm development	56	63	1.21e-02
GO:BP	GO:0086001	cardiac muscle cell action potential	56	63	1.21e-02
GO:BP	GO:0032535	regulation of cellular component size	228	287	1.21e-02
GO:BP	GO:0010232	vascular transport	60	68	1.21e-02
GO:BP	GO:0019915	lipid storage	60	68	1.21e-02
GO:BP	GO:0043502	regulation of muscle adaptation	60	68	1.21e-02
GO:BP	GO:0150104	transport across blood-brain barrier	60	68	1.21e-02
GO:BP	GO:0071675	regulation of mononuclear cell migration	60	68	1.21e-02
GO:BP	GO:0150117	positive regulation of cell-substrate junction organization	28	29	1.24e-02
GO:BP	GO:0060563	neuroepithelial cell differentiation	28	29	1.24e-02
GO:BP	GO:1990776	response to angiotensin	28	29	1.24e-02
GO:BP	GO:0002067	glandular epithelial cell differentiation	43	47	1.24e-02
GO:BP	GO:0014743	regulation of muscle hypertrophy	43	47	1.24e-02
GO:BP	GO:0014015	positive regulation of gliogenesis	43	47	1.24e-02
GO:BP	GO:0045860	positive regulation of protein kinase activity	150	184	1.26e-02
GO:BP	GO:0070252	actin-mediated cell contraction	75	87	1.29e-02
GO:BP	GO:0008104	protein localization	1478	2000	1.34e-02
GO:BP	GO:0018193	peptidyl-amino acid modification	427	555	1.34e-02
GO:BP	GO:1905314	semi-lunar valve development	38	41	1.35e-02
GO:BP	GO:0022409	positive regulation of cell-cell adhesion	143	175	1.35e-02
GO:BP	GO:1905330	regulation of morphogenesis of an epithelium	38	41	1.35e-02
GO:BP	GO:0010171	body morphogenesis	38	41	1.35e-02
GO:BP	GO:0001936	regulation of endothelial cell proliferation	82	96	1.37e-02
GO:BP	GO:0070727	cellular macromolecule localization	1485	2010	1.38e-02
GO:BP	GO:0045444	fat cell differentiation	146	179	1.39e-02
GO:BP	GO:0001935	endothelial cell proliferation	96	114	1.40e-02
GO:BP	GO:0051090	regulation of DNA-binding transcription factor activity	193	241	1.40e-02
GO:BP	GO:0051492	regulation of stress fiber assembly	67	77	1.40e-02
GO:BP	GO:0050863	regulation of T cell activation	165	204	1.40e-02
GO:BP	GO:0051046	regulation of secretion	309	396	1.43e-02
GO:BP	GO:1904892	regulation of receptor signaling pathway via STAT	51	57	1.43e-02
GO:BP	GO:0055013	cardiac muscle cell development	63	72	1.43e-02
GO:BP	GO:0014812	muscle cell migration	63	72	1.43e-02
GO:BP	GO:0008589	regulation of smoothened signaling pathway	63	72	1.43e-02
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	208	261	1.44e-02
GO:BP	GO:0060384	innervation	21	21	1.45e-02
GO:BP	GO:0042634	regulation of hair cycle	21	21	1.45e-02
GO:BP	GO:0007224	smoothened signaling pathway	99	118	1.50e-02
GO:BP	GO:0035019	somatic stem cell population maintenance	42	46	1.55e-02
GO:BP	GO:0072171	mesonephric tubule morphogenesis	42	46	1.55e-02
GO:BP	GO:0003197	endocardial cushion development	42	46	1.55e-02
GO:BP	GO:0010611	regulation of cardiac muscle hypertrophy	42	46	1.55e-02
GO:BP	GO:0032868	response to insulin	164	203	1.58e-02
GO:BP	GO:0016266	O-glycan processing	27	28	1.60e-02
GO:BP	GO:0048675	axon extension	81	95	1.60e-02
GO:BP	GO:0098739	import across plasma membrane	102	122	1.60e-02
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	1326	1791	1.60e-02
GO:BP	GO:0038127	ERBB signaling pathway	88	104	1.64e-02
GO:BP	GO:0072132	mesenchyme morphogenesis	46	51	1.68e-02
GO:BP	GO:0099003	vesicle-mediated transport in synapse	138	169	1.70e-02
GO:BP	GO:0048286	lung alveolus development	37	40	1.71e-02
GO:BP	GO:0002376	immune system process	1050	1410	1.72e-02
GO:BP	GO:0006954	inflammatory response	330	425	1.72e-02
GO:BP	GO:0006915	apoptotic process	1026	1377	1.74e-02
GO:BP	GO:0003229	ventricular cardiac muscle tissue development	50	56	1.75e-02
GO:BP	GO:0062013	positive regulation of small molecule metabolic process	84	99	1.77e-02
GO:BP	GO:0071230	cellular response to amino acid stimulus	58	66	1.77e-02
GO:BP	GO:0060415	muscle tissue morphogenesis	54	61	1.78e-02
GO:BP	GO:1903530	regulation of secretion by cell	286	366	1.81e-02
GO:BP	GO:0048640	negative regulation of developmental growth	73	85	1.82e-02
GO:BP	GO:0031667	response to nutrient levels	277	354	1.85e-02
GO:BP	GO:0051251	positive regulation of lymphocyte activation	150	185	1.87e-02
GO:BP	GO:0001704	formation of primary germ layer	80	94	1.90e-02
GO:BP	GO:0140747	regulation of ncRNA transcription	69	80	1.93e-02
GO:BP	GO:0060675	ureteric bud morphogenesis	41	45	1.94e-02
GO:BP	GO:0090183	regulation of kidney development	20	20	1.96e-02
GO:BP	GO:0002053	positive regulation of mesenchymal cell proliferation	20	20	1.96e-02
GO:BP	GO:0014070	response to organic cyclic compound	463	606	2.10e-02
GO:BP	GO:0090497	mesenchymal cell migration	45	50	2.10e-02
GO:BP	GO:0072210	metanephric nephron development	26	27	2.11e-02
GO:BP	GO:1904385	cellular response to angiotensin	26	27	2.11e-02
GO:BP	GO:0060416	response to growth hormone	26	27	2.11e-02
GO:BP	GO:1904646	cellular response to amyloid-beta	26	27	2.11e-02
GO:BP	GO:0055008	cardiac muscle tissue morphogenesis	49	55	2.16e-02
GO:BP	GO:0046578	regulation of Ras protein signal transduction	36	39	2.16e-02
GO:BP	GO:0021536	diencephalon development	36	39	2.16e-02
GO:BP	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	49	55	2.16e-02
GO:BP	GO:0051983	regulation of chromosome segregation	100	120	2.17e-02
GO:BP	GO:0014909	smooth muscle cell migration	53	60	2.17e-02
GO:BP	GO:0051301	cell division	415	541	2.17e-02
GO:BP	GO:0046683	response to organophosphorus	79	93	2.24e-02
GO:BP	GO:0001508	action potential	86	102	2.26e-02
GO:BP	GO:0050801	monoatomic ion homeostasis	315	406	2.34e-02
GO:BP	GO:0009792	embryo development ending in birth or egg hatching	400	521	2.36e-02
GO:BP	GO:0007548	sex differentiation	145	179	2.36e-02
GO:BP	GO:0030217	T cell differentiation	148	183	2.41e-02
GO:BP	GO:0006638	neutral lipid metabolic process	75	88	2.41e-02
GO:BP	GO:0061387	regulation of extent of cell growth	75	88	2.41e-02
GO:BP	GO:1902903	regulation of supramolecular fiber organization	239	304	2.42e-02
GO:BP	GO:0031644	regulation of nervous system process	64	74	2.42e-02
GO:BP	GO:0051649	establishment of localization in cell	1161	1566	2.42e-02
GO:BP	GO:0014074	response to purine-containing compound	89	106	2.43e-02
GO:BP	GO:0008277	regulation of G protein-coupled receptor signaling pathway	82	97	2.44e-02
GO:BP	GO:0044772	mitotic cell cycle phase transition	297	382	2.48e-02
GO:BP	GO:0035264	multicellular organism growth	99	119	2.51e-02
GO:BP	GO:0035051	cardiocyte differentiation	109	132	2.51e-02
GO:BP	GO:0045685	regulation of glial cell differentiation	44	49	2.57e-02
GO:BP	GO:0046942	carboxylic acid transport	163	203	2.57e-02
GO:BP	GO:0090263	positive regulation of canonical Wnt signaling pathway	71	83	2.57e-02
GO:BP	GO:0086003	cardiac muscle cell contraction	56	64	2.60e-02
GO:BP	GO:0060740	prostate gland epithelium morphogenesis	19	19	2.62e-02
GO:BP	GO:0010878	cholesterol storage	19	19	2.62e-02
GO:BP	GO:0060512	prostate gland morphogenesis	19	19	2.62e-02
GO:BP	GO:0048566	embryonic digestive tract development	19	19	2.62e-02
GO:BP	GO:0071378	cellular response to growth hormone stimulus	19	19	2.62e-02
GO:BP	GO:0003184	pulmonary valve morphogenesis	19	19	2.62e-02
GO:BP	GO:2000027	regulation of animal organ morphogenesis	52	59	2.63e-02
GO:BP	GO:0046503	glycerolipid catabolic process	35	38	2.70e-02
GO:BP	GO:0045668	negative regulation of osteoblast differentiation	35	38	2.70e-02
GO:BP	GO:0002066	columnar/cuboidal epithelial cell development	35	38	2.70e-02
GO:BP	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	35	38	2.70e-02
GO:BP	GO:0050773	regulation of dendrite development	67	78	2.71e-02
GO:BP	GO:0030510	regulation of BMP signaling pathway	67	78	2.71e-02
GO:BP	GO:0009991	response to extracellular stimulus	293	377	2.71e-02
GO:BP	GO:0010092	specification of animal organ identity	25	26	2.72e-02
GO:BP	GO:0000278	mitotic cell cycle	577	763	2.73e-02
GO:BP	GO:0070371	ERK1 and ERK2 cascade	156	194	2.80e-02
GO:BP	GO:0006639	acylglycerol metabolic process	74	87	2.81e-02
GO:BP	GO:0007613	memory	74	87	2.81e-02
GO:BP	GO:0043009	chordate embryonic development	389	507	2.83e-02
GO:BP	GO:0030501	positive regulation of bone mineralization	30	32	2.85e-02
GO:BP	GO:0071604	transforming growth factor beta production	30	32	2.85e-02
GO:BP	GO:0072583	clathrin-dependent endocytosis	39	43	3.00e-02
GO:BP	GO:0072659	protein localization to plasma membrane	189	238	3.02e-02
GO:BP	GO:0044784	metaphase/anaphase transition of cell cycle	77	91	3.08e-02
GO:BP	GO:0034767	positive regulation of monoatomic ion transmembrane transport	77	91	3.08e-02
GO:BP	GO:0006637	acyl-CoA metabolic process	55	63	3.11e-02
GO:BP	GO:0002688	regulation of leukocyte chemotaxis	55	63	3.11e-02
GO:BP	GO:0035383	thioester metabolic process	55	63	3.11e-02
GO:BP	GO:0002694	regulation of leukocyte activation	245	313	3.13e-02
GO:BP	GO:0051058	negative regulation of small GTPase mediated signal transduction	43	48	3.15e-02
GO:BP	GO:0008219	cell death	1056	1423	3.15e-02
GO:BP	GO:0022408	negative regulation of cell-cell adhesion	94	113	3.16e-02
GO:BP	GO:0008543	fibroblast growth factor receptor signaling pathway	51	58	3.17e-02
GO:BP	GO:0033674	positive regulation of kinase activity	158	197	3.17e-02
GO:BP	GO:0048844	artery morphogenesis	51	58	3.17e-02
GO:BP	GO:0012501	programmed cell death	1053	1419	3.20e-02
GO:BP	GO:0032526	response to retinoic acid	66	77	3.20e-02
GO:BP	GO:0033993	response to lipid	437	573	3.31e-02
GO:BP	GO:0099504	synaptic vesicle cycle	123	151	3.37e-02
GO:BP	GO:0003176	aortic valve development	34	37	3.39e-02
GO:BP	GO:0070169	positive regulation of biomineral tissue development	34	37	3.39e-02
GO:BP	GO:1902305	regulation of sodium ion transmembrane transport	34	37	3.39e-02
GO:BP	GO:0009611	response to wounding	296	382	3.43e-02
GO:BP	GO:0016049	cell growth	296	382	3.43e-02
GO:BP	GO:0045926	negative regulation of growth	148	184	3.44e-02
GO:BP	GO:1903169	regulation of calcium ion transmembrane transport	90	108	3.45e-02
GO:BP	GO:0035336	long-chain fatty-acyl-CoA metabolic process	18	18	3.49e-02
GO:BP	GO:0010743	regulation of macrophage derived foam cell differentiation	18	18	3.49e-02
GO:BP	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway	18	18	3.49e-02
GO:BP	GO:0060396	growth hormone receptor signaling pathway	18	18	3.49e-02
GO:BP	GO:0055080	monoatomic cation homeostasis	310	401	3.49e-02
GO:BP	GO:0006909	phagocytosis	113	138	3.49e-02
GO:BP	GO:1902905	positive regulation of supramolecular fiber organization	113	138	3.49e-02
GO:BP	GO:0035025	positive regulation of Rho protein signal transduction	24	25	3.50e-02
GO:BP	GO:0099171	presynaptic modulation of chemical synaptic transmission	24	25	3.50e-02
GO:BP	GO:0060351	cartilage development involved in endochondral bone morphogenesis	24	25	3.50e-02
GO:BP	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	76	90	3.57e-02
GO:BP	GO:0015849	organic acid transport	163	204	3.57e-02
GO:BP	GO:0007219	Notch signaling pathway	116	142	3.58e-02
GO:BP	GO:1902904	negative regulation of supramolecular fiber organization	103	125	3.58e-02
GO:BP	GO:0071634	regulation of transforming growth factor beta production	29	31	3.59e-02
GO:BP	GO:0045687	positive regulation of glial cell differentiation	29	31	3.59e-02
GO:BP	GO:0030857	negative regulation of epithelial cell differentiation	29	31	3.59e-02
GO:BP	GO:1904645	response to amyloid-beta	29	31	3.59e-02
GO:BP	GO:0060688	regulation of morphogenesis of a branching structure	29	31	3.59e-02
GO:BP	GO:0106106	cold-induced thermogenesis	93	112	3.59e-02
GO:BP	GO:0019058	viral life cycle	184	232	3.64e-02
GO:BP	GO:0051591	response to cAMP	54	62	3.68e-02
GO:BP	GO:0070372	regulation of ERK1 and ERK2 cascade	141	175	3.71e-02
GO:BP	GO:0030705	cytoskeleton-dependent intracellular transport	144	179	3.77e-02
GO:BP	GO:0051899	membrane depolarization	50	57	3.78e-02
GO:BP	GO:0097009	energy homeostasis	50	57	3.78e-02
GO:BP	GO:0032147	activation of protein kinase activity	50	57	3.78e-02
GO:BP	GO:0033555	multicellular organismal response to stress	50	57	3.78e-02
GO:BP	GO:0009953	dorsal/ventral pattern formation	42	47	3.79e-02
GO:BP	GO:0051653	spindle localization	46	52	3.82e-02
GO:BP	GO:0001708	cell fate specification	46	52	3.82e-02
GO:BP	GO:0048863	stem cell differentiation	153	191	3.87e-02
GO:BP	GO:0006629	lipid metabolic process	692	923	3.92e-02
GO:BP	GO:0033045	regulation of sister chromatid segregation	82	98	4.09e-02
GO:BP	GO:0120161	regulation of cold-induced thermogenesis	92	111	4.16e-02
GO:BP	GO:0048813	dendrite morphogenesis	92	111	4.16e-02
GO:BP	GO:0010876	lipid localization	233	298	4.16e-02
GO:BP	GO:0051495	positive regulation of cytoskeleton organization	118	145	4.17e-02
GO:BP	GO:0038179	neurotrophin signaling pathway	33	36	4.19e-02
GO:BP	GO:0044272	sulfur compound biosynthetic process	105	128	4.24e-02
GO:BP	GO:1903708	positive regulation of hemopoiesis	95	115	4.35e-02
GO:BP	GO:1902107	positive regulation of leukocyte differentiation	95	115	4.35e-02
GO:BP	GO:0046649	lymphocyte activation	341	444	4.38e-02
GO:BP	GO:0035567	non-canonical Wnt signaling pathway	53	61	4.43e-02
GO:BP	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	53	61	4.43e-02
GO:BP	GO:0042303	molting cycle	64	75	4.44e-02
GO:BP	GO:0042633	hair cycle	64	75	4.44e-02
GO:BP	GO:0045453	bone resorption	37	41	4.48e-02
GO:BP	GO:0048872	homeostasis of number of cells	176	222	4.48e-02
GO:BP	GO:0021952	central nervous system projection neuron axonogenesis	23	24	4.48e-02
GO:BP	GO:0022029	telencephalon cell migration	37	41	4.48e-02
GO:BP	GO:0010812	negative regulation of cell-substrate adhesion	37	41	4.48e-02
GO:BP	GO:0003272	endocardial cushion formation	23	24	4.48e-02
GO:BP	GO:0051894	positive regulation of focal adhesion assembly	23	24	4.48e-02
GO:BP	GO:0061383	trabecula morphogenesis	37	41	4.48e-02
GO:BP	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	170	214	4.48e-02
GO:BP	GO:0045124	regulation of bone resorption	23	24	4.48e-02
GO:BP	GO:0051146	striated muscle cell differentiation	185	234	4.48e-02
GO:BP	GO:2000737	negative regulation of stem cell differentiation	23	24	4.48e-02
GO:BP	GO:0050919	negative chemotaxis	37	41	4.48e-02
GO:BP	GO:0002431	Fc receptor mediated stimulatory signaling pathway	23	24	4.48e-02
GO:BP	GO:0046661	male sex differentiation	88	106	4.50e-02
GO:BP	GO:0001937	negative regulation of endothelial cell proliferation	28	30	4.50e-02
GO:BP	GO:0060914	heart formation	28	30	4.50e-02
GO:BP	GO:0001974	blood vessel remodeling	28	30	4.50e-02
GO:BP	GO:0060323	head morphogenesis	28	30	4.50e-02
GO:BP	GO:1901990	regulation of mitotic cell cycle phase transition	229	293	4.51e-02
GO:BP	GO:0016032	viral process	255	328	4.53e-02
GO:BP	GO:0034505	tooth mineralization	17	17	4.53e-02
GO:BP	GO:0009065	glutamine family amino acid catabolic process	17	17	4.53e-02
GO:BP	GO:0003215	cardiac right ventricle morphogenesis	17	17	4.53e-02
GO:BP	GO:0032528	microvillus organization	17	17	4.53e-02
GO:BP	GO:0060977	coronary vasculature morphogenesis	17	17	4.53e-02
GO:BP	GO:0050771	negative regulation of axonogenesis	45	51	4.57e-02
GO:BP	GO:0006865	amino acid transport	81	97	4.64e-02
GO:BP	GO:0006470	protein dephosphorylation	142	177	4.64e-02
GO:BP	GO:0070482	response to oxygen levels	208	265	4.71e-02
GO:BP	GO:0006869	lipid transport	205	261	4.73e-02
GO:BP	GO:0051494	negative regulation of cytoskeleton organization	104	127	4.74e-02
GO:BP	GO:0008593	regulation of Notch signaling pathway	67	79	4.76e-02
GO:BP	GO:0035303	regulation of dephosphorylation	67	79	4.76e-02
GO:BP	GO:0002573	myeloid leukocyte differentiation	123	152	4.81e-02
GO:BP	GO:0006887	exocytosis	187	237	4.84e-02
GO:BP	GO:0001942	hair follicle development	56	65	4.93e-02

LRnomtable %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in LR neargenes") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in LR neargenes

source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:05200	Pathways in cancer	328	391	3.55e-07
KEGG	KEGG:04360	Axon guidance	137	155	2.59e-05
KEGG	KEGG:05205	Proteoglycans in cancer	142	162	3.40e-05
KEGG	KEGG:04971	Gastric acid secretion	50	51	4.56e-05
KEGG	KEGG:04310	Wnt signaling pathway	118	133	4.79e-05
KEGG	KEGG:04024	cAMP signaling pathway	129	147	5.16e-05
KEGG	KEGG:04510	Focal adhesion	146	169	7.29e-05
KEGG	KEGG:04015	Rap1 signaling pathway	140	162	8.94e-05
KEGG	KEGG:04970	Salivary secretion	52	54	8.94e-05
KEGG	KEGG:04014	Ras signaling pathway	141	164	1.28e-04
KEGG	KEGG:04520	Adherens junction	76	83	1.28e-04
KEGG	KEGG:04022	cGMP-PKG signaling pathway	113	129	1.52e-04
KEGG	KEGG:04550	Signaling pathways regulating pluripotency of stem cells	90	101	2.61e-04
KEGG	KEGG:04611	Platelet activation	79	88	4.18e-04
KEGG	KEGG:04020	Calcium signaling pathway	137	161	4.18e-04
KEGG	KEGG:04810	Regulation of actin cytoskeleton	143	169	4.86e-04
KEGG	KEGG:05163	Human cytomegalovirus infection	135	160	9.35e-04
KEGG	KEGG:04928	Parathyroid hormone synthesis, secretion and action	70	78	9.35e-04
KEGG	KEGG:04924	Renin secretion	47	50	9.35e-04
KEGG	KEGG:04911	Insulin secretion	57	62	9.35e-04
KEGG	KEGG:05146	Amoebiasis	57	62	9.35e-04
KEGG	KEGG:04512	ECM-receptor interaction	60	66	1.17e-03
KEGG	KEGG:04270	Vascular smooth muscle contraction	81	92	1.17e-03
KEGG	KEGG:04010	MAPK signaling pathway	189	231	1.24e-03
KEGG	KEGG:04925	Aldosterone synthesis and secretion	67	75	1.55e-03
KEGG	KEGG:04916	Melanogenesis	67	75	1.55e-03
KEGG	KEGG:04918	Thyroid hormone synthesis	49	53	1.59e-03
KEGG	KEGG:04927	Cortisol synthesis and secretion	43	46	2.09e-03
KEGG	KEGG:04972	Pancreatic secretion	52	57	2.29e-03
KEGG	KEGG:04151	PI3K-Akt signaling pathway	202	250	2.43e-03
KEGG	KEGG:04148	Efferocytosis	102	120	2.50e-03
KEGG	KEGG:04933	AGE-RAGE signaling pathway in diabetic complications	76	87	2.50e-03
KEGG	KEGG:04390	Hippo signaling pathway	109	129	2.50e-03
KEGG	KEGG:04974	Protein digestion and absorption	51	56	2.53e-03
KEGG	KEGG:04261	Adrenergic signaling in cardiomyocytes	105	124	2.57e-03
KEGG	KEGG:05165	Human papillomavirus infection	202	252	4.72e-03
KEGG	KEGG:04728	Dopaminergic synapse	83	97	5.30e-03
KEGG	KEGG:04713	Circadian entrainment	60	68	5.44e-03
KEGG	KEGG:04976	Bile secretion	38	41	6.05e-03
KEGG	KEGG:04750	Inflammatory mediator regulation of TRP channels	63	72	6.33e-03
KEGG	KEGG:05412	Arrhythmogenic right ventricular cardiomyopathy	59	67	6.33e-03
KEGG	KEGG:04926	Relaxin signaling pathway	85	100	6.37e-03
KEGG	KEGG:04961	Endocrine and other factor-regulated calcium reabsorption	37	40	7.11e-03
KEGG	KEGG:04350	TGF-beta signaling pathway	77	90	7.11e-03
KEGG	KEGG:05417	Lipid and atherosclerosis	118	143	7.35e-03
KEGG	KEGG:04658	Th1 and Th2 cell differentiation	45	50	8.33e-03
KEGG	KEGG:04072	Phospholipase D signaling pathway	90	107	8.33e-03
KEGG	KEGG:04730	Long-term depression	36	39	8.49e-03
KEGG	KEGG:04630	JAK-STAT signaling pathway	71	83	1.00e-02
KEGG	KEGG:04340	Hedgehog signaling pathway	44	49	1.00e-02
KEGG	KEGG:04935	Growth hormone synthesis, secretion and action	81	96	1.09e-02
KEGG	KEGG:04919	Thyroid hormone signaling pathway	88	105	1.09e-02
KEGG	KEGG:05418	Fluid shear stress and atherosclerosis	91	109	1.13e-02
KEGG	KEGG:05414	Dilated cardiomyopathy	70	82	1.13e-02
KEGG	KEGG:05167	Kaposi sarcoma-associated herpesvirus infection	110	134	1.28e-02
KEGG	KEGG:04915	Estrogen signaling pathway	76	90	1.34e-02
KEGG	KEGG:04670	Leukocyte transendothelial migration	65	76	1.41e-02
KEGG	KEGG:05135	Yersinia infection	89	107	1.46e-02
KEGG	KEGG:05207	Chemical carcinogenesis - receptor activation	108	132	1.63e-02
KEGG	KEGG:04659	Th17 cell differentiation	52	60	2.00e-02
KEGG	KEGG:04514	Cell adhesion molecules	59	69	2.11e-02
KEGG	KEGG:04921	Oxytocin signaling pathway	93	113	2.12e-02
KEGG	KEGG:04371	Apelin signaling pathway	86	104	2.23e-02
KEGG	KEGG:04725	Cholinergic synapse	69	82	2.25e-02
KEGG	KEGG:04071	Sphingolipid signaling pathway	85	103	2.51e-02
KEGG	KEGG:00000	KEGG root term	3931	5451	2.51e-02
KEGG	KEGG:05210	Colorectal cancer	68	81	2.57e-02
KEGG	KEGG:04726	Serotonergic synapse	50	58	2.69e-02
KEGG	KEGG:04660	T cell receptor signaling pathway	70	84	3.20e-02
KEGG	KEGG:00512	Mucin type O-glycan biosynthesis	20	21	3.56e-02
KEGG	KEGG:03320	PPAR signaling pathway	41	47	3.59e-02
KEGG	KEGG:04625	C-type lectin receptor signaling pathway	62	74	3.77e-02
KEGG	KEGG:04724	Glutamatergic synapse	62	74	3.77e-02
KEGG	KEGG:05170	Human immunodeficiency virus 1 infection	119	149	3.95e-02
KEGG	KEGG:04720	Long-term potentiation	44	51	3.96e-02
KEGG	KEGG:05206	MicroRNAs in cancer	115	144	4.31e-02
KEGG	KEGG:04923	Regulation of lipolysis in adipocytes	36	41	4.31e-02
KEGG	KEGG:04742	Taste transduction	19	20	4.32e-02
KEGG	KEGG:05410	Hypertrophic cardiomyopathy	64	77	4.43e-02
KEGG	KEGG:04934	Cushing syndrome	96	119	4.45e-02
KEGG	KEGG:05130	Pathogenic Escherichia coli infection	114	143	4.67e-02
KEGG	KEGG:01521	EGFR tyrosine kinase inhibitor resistance	60	72	4.78e-02
KEGG	KEGG:05032	Morphine addiction	46	54	4.96e-02

NR response genes

# NR_resgenes <- gost(query = NR_NG_list$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(NR_resgenes,"data/GO_KEGG_analysis/NR_resgenes.RDS")

NRnom <- gostplot(NR_resgenes, capped = FALSE, interactive = TRUE)
# NRnom

NRnomtable <- NR_resgenes$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

NRnomtable %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in NR neargenes" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in NR neargenes

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0007275	multicellular organism development	3082	3170	4.30e-05
GO:BP	GO:0032501	multicellular organismal process	4362	4504	4.30e-05
GO:BP	GO:0048523	negative regulation of cellular process	3446	3550	4.40e-05
GO:BP	GO:0051716	cellular response to stimulus	4491	4640	4.44e-05
GO:BP	GO:0007010	cytoskeleton organization	1127	1146	7.38e-05
GO:BP	GO:0048731	system development	2645	2719	7.49e-05
GO:BP	GO:0048856	anatomical structure development	3748	3867	7.49e-05
GO:BP	GO:0050896	response to stimulus	5196	5379	8.02e-05
GO:BP	GO:0050794	regulation of cellular process	6888	7153	2.38e-04
GO:BP	GO:0065007	biological regulation	7441	7734	3.22e-04
GO:BP	GO:0007154	cell communication	3855	3983	3.67e-04
GO:BP	GO:0048519	negative regulation of biological process	3645	3764	3.67e-04
GO:BP	GO:0009653	anatomical structure morphogenesis	1799	1844	3.67e-04
GO:BP	GO:0050789	regulation of biological process	7232	7516	3.99e-04
GO:BP	GO:0023052	signaling	3792	3918	4.48e-04
GO:BP	GO:0032502	developmental process	4042	4179	4.62e-04
GO:BP	GO:0008150	biological_process	10770	11244	6.46e-04
GO:BP	GO:0051128	regulation of cellular component organization	1815	1862	6.81e-04
GO:BP	GO:0071495	cellular response to endogenous stimulus	1016	1035	6.93e-04
GO:BP	GO:0050793	regulation of developmental process	1655	1697	1.16e-03
GO:BP	GO:0007165	signal transduction	3495	3611	1.16e-03
GO:BP	GO:0023051	regulation of signaling	2368	2438	1.48e-03
GO:BP	GO:0048583	regulation of response to stimulus	2636	2717	1.58e-03
GO:BP	GO:0009966	regulation of signal transduction	2106	2166	1.65e-03
GO:BP	GO:0007399	nervous system development	1729	1775	2.13e-03
GO:BP	GO:0016477	cell migration	991	1011	2.73e-03
GO:BP	GO:0022008	neurogenesis	1223	1251	2.76e-03
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	601	609	2.83e-03
GO:BP	GO:0000902	cell morphogenesis	702	713	2.92e-03
GO:BP	GO:0010646	regulation of cell communication	2372	2444	2.95e-03
GO:BP	GO:0030029	actin filament-based process	631	640	3.04e-03
GO:BP	GO:0048518	positive regulation of biological process	4153	4301	3.42e-03
GO:BP	GO:0009888	tissue development	1316	1348	3.77e-03
GO:BP	GO:0048522	positive regulation of cellular process	3820	3954	4.19e-03
GO:BP	GO:0048699	generation of neurons	1053	1076	4.37e-03
GO:BP	GO:0007155	cell adhesion	922	941	6.18e-03
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	821	837	8.05e-03
GO:BP	GO:0009719	response to endogenous stimulus	1169	1197	8.05e-03
GO:BP	GO:0016043	cellular component organization	4630	4802	8.05e-03
GO:BP	GO:0009987	cellular process	10236	10686	8.78e-03
GO:BP	GO:0030036	actin cytoskeleton organization	558	566	8.78e-03
GO:BP	GO:0030182	neuron differentiation	992	1014	8.85e-03
GO:BP	GO:0048513	animal organ development	1946	2004	1.02e-02
GO:BP	GO:0065008	regulation of biological quality	1839	1893	1.13e-02
GO:BP	GO:0035295	tube development	772	787	1.14e-02
GO:BP	GO:0048870	cell motility	1094	1120	1.14e-02
GO:BP	GO:0048869	cellular developmental process	2714	2804	1.27e-02
GO:BP	GO:0030154	cell differentiation	2713	2803	1.27e-02
GO:BP	GO:0007267	cell-cell signaling	1057	1082	1.32e-02
GO:BP	GO:0007015	actin filament organization	354	357	1.44e-02
GO:BP	GO:0051239	regulation of multicellular organismal process	1868	1924	1.54e-02
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	260	261	1.76e-02
GO:BP	GO:0048468	cell development	1831	1886	1.89e-02
GO:BP	GO:0031589	cell-substrate adhesion	257	258	1.90e-02
GO:BP	GO:1901700	response to oxygen-containing compound	1067	1093	1.90e-02
GO:BP	GO:0097435	supramolecular fiber organization	622	633	2.02e-02
GO:BP	GO:0032970	regulation of actin filament-based process	298	300	2.24e-02
GO:BP	GO:0035556	intracellular signal transduction	1893	1951	2.27e-02
GO:BP	GO:0032989	cellular anatomical entity morphogenesis	578	588	2.81e-02
GO:BP	GO:0071840	cellular component organization or biogenesis	4802	4988	4.57e-02
GO:BP	GO:0023056	positive regulation of signaling	1189	1221	4.59e-02
GO:BP	GO:0006996	organelle organization	2721	2815	4.63e-02
GO:BP	GO:0010647	positive regulation of cell communication	1186	1218	4.77e-02

NRnomtable %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in NR neargenes") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in NR neargenes

source	term_id	term_name	intersection_size	term_size	p_value
NA	NA	NA	NA	NA	NA
:——	:——-	:———	—————–:	———:	:——-

Peaks within 20,000 bps of assigned nearest expressed gene, GO and KEGG enrichment

# exp_neargene_table <- read_delim("data/n45_bedfiles/exp_neargene_table.tsv", 
#     delim = "\t", escape_double = FALSE, 
#     trim_ws = TRUE)

# col_ng_peak <- exp_neargene_table %>%
#   group_by(chr, start, end, peakid) %>%
#     summarise(NCBI_gene = paste(unique(ENTREZID),collapse=","),
#               ensembl_ID= paste(unique(ensembl_id),collapse = ","),
#               SYMBOL= paste(unique(SYMBOL),collapse = ",") , 
#               dist_to_NG =min(dist_to_NG)) %>% 
#   ungroup()

# write.csv(col_ng_peak, "data/Collapsed_expressed_NG_peak_table.csv")
col_ng_peak <- read.csv("data/Collapsed_expressed_NG_peak_table.csv", row.names = 1)

EAR_peak_list_20k <-  col_ng_peak %>%
  dplyr::filter(dist_to_NG<20000) %>% 
    dplyr::filter(peakid %in% EAR_df$id) 

ESR_peak_list_20k <- col_ng_peak %>%
  dplyr::filter(dist_to_NG<20000) %>% 
    dplyr::filter(peakid %in% ESR_df$id) 

LR_peak_list_20k <- col_ng_peak %>%
  dplyr::filter(dist_to_NG<20000) %>% 
    dplyr::filter(peakid %in% LR_df$id) 

NR_peak_list_20k <- col_ng_peak %>%
  dplyr::filter(dist_to_NG<20000) %>% 
    dplyr::filter(peakid %in% NR_df$id) 

EAR 20,000 bp NG

# EAR_resgenes_20k <- gost(query = EAR_peak_list_20k$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(EAR_resgenes_20k,"data/GO_KEGG_analysis/EAR_resgenes_20k.RDS")


EARnom <- gostplot(EAR_resgenes_20k, capped = FALSE, interactive = TRUE)
# EARnom

EARnomtable_20k <- EAR_resgenes_20k$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

EARnomtable_20k %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in EAR neargenes_20k" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in EAR neargenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0009653	anatomical structure morphogenesis	700	1844	9.84e-20
GO:BP	GO:0048856	anatomical structure development	1307	3867	8.91e-18
GO:BP	GO:0032502	developmental process	1397	4179	1.19e-17
GO:BP	GO:0032501	multicellular organismal process	1481	4504	5.39e-16
GO:BP	GO:0007275	multicellular organism development	1086	3170	8.40e-16
GO:BP	GO:0048731	system development	948	2719	1.49e-15
GO:BP	GO:0048869	cellular developmental process	972	2804	2.68e-15
GO:BP	GO:0050793	regulation of developmental process	629	1697	2.85e-15
GO:BP	GO:0030154	cell differentiation	971	2803	2.85e-15
GO:BP	GO:0050789	regulation of biological process	2316	7516	1.46e-14
GO:BP	GO:0065007	biological regulation	2368	7734	1.72e-13
GO:BP	GO:0050794	regulation of cellular process	2207	7153	3.23e-13
GO:BP	GO:0023052	signaling	1286	3918	9.00e-13
GO:BP	GO:0007154	cell communication	1304	3983	1.18e-12
GO:BP	GO:0048699	generation of neurons	414	1076	4.57e-12
GO:BP	GO:0022008	neurogenesis	469	1251	9.52e-12
GO:BP	GO:0051239	regulation of multicellular organismal process	680	1924	1.19e-11
GO:BP	GO:0007165	signal transduction	1187	3611	1.30e-11
GO:BP	GO:0072359	circulatory system development	340	864	3.97e-11
GO:BP	GO:0016477	cell migration	387	1011	7.21e-11
GO:BP	GO:0030182	neuron differentiation	387	1014	1.13e-10
GO:BP	GO:0048468	cell development	658	1886	5.47e-10
GO:BP	GO:0048519	negative regulation of biological process	1219	3764	6.07e-10
GO:BP	GO:0050896	response to stimulus	1681	5379	1.37e-09
GO:BP	GO:0007399	nervous system development	621	1775	1.42e-09
GO:BP	GO:0048523	negative regulation of cellular process	1153	3550	1.49e-09
GO:BP	GO:0048870	cell motility	415	1120	1.76e-09
GO:BP	GO:0051716	cellular response to stimulus	1468	4640	2.02e-09
GO:BP	GO:2000145	regulation of cell motility	277	700	3.21e-09
GO:BP	GO:0030334	regulation of cell migration	266	668	3.76e-09
GO:BP	GO:0048666	neuron development	322	838	3.90e-09
GO:BP	GO:0141124	intracellular signaling cassette	474	1314	4.50e-09
GO:BP	GO:0010975	regulation of neuron projection development	158	355	4.59e-09
GO:BP	GO:0034330	cell junction organization	224	545	4.64e-09
GO:BP	GO:0048513	animal organ development	687	2004	4.83e-09
GO:BP	GO:0040012	regulation of locomotion	282	720	6.38e-09
GO:BP	GO:0030029	actin filament-based process	255	640	7.81e-09
GO:BP	GO:0031344	regulation of cell projection organization	213	516	7.92e-09
GO:BP	GO:0051128	regulation of cellular component organization	642	1862	7.92e-09
GO:BP	GO:0031175	neuron projection development	289	743	7.92e-09
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	209	505	9.01e-09
GO:BP	GO:0035556	intracellular signal transduction	668	1951	1.11e-08
GO:BP	GO:0000902	cell morphogenesis	278	713	1.33e-08
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	243	609	1.67e-08
GO:BP	GO:0048518	positive regulation of biological process	1360	4301	2.23e-08
GO:BP	GO:0040011	locomotion	307	805	2.26e-08
GO:BP	GO:0048522	positive regulation of cellular process	1257	3954	4.34e-08
GO:BP	GO:0010646	regulation of cell communication	809	2444	1.24e-07
GO:BP	GO:0007155	cell adhesion	347	941	1.33e-07
GO:BP	GO:0009887	animal organ morphogenesis	260	673	1.46e-07
GO:BP	GO:0051094	positive regulation of developmental process	337	913	2.04e-07
GO:BP	GO:0065008	regulation of biological quality	641	1893	2.19e-07
GO:BP	GO:0023051	regulation of signaling	804	2438	2.96e-07
GO:BP	GO:0007507	heart development	199	499	8.15e-07
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	308	837	1.51e-06
GO:BP	GO:0009966	regulation of signal transduction	717	2166	1.51e-06
GO:BP	GO:0003008	system process	403	1139	1.73e-06
GO:BP	GO:0022604	regulation of cell morphogenesis	91	193	1.94e-06
GO:BP	GO:0009888	tissue development	467	1348	2.31e-06
GO:BP	GO:2000026	regulation of multicellular organismal development	343	951	2.39e-06
GO:BP	GO:0045595	regulation of cell differentiation	381	1073	2.73e-06
GO:BP	GO:0009790	embryo development	301	821	3.13e-06
GO:BP	GO:0030036	actin cytoskeleton organization	218	566	3.95e-06
GO:BP	GO:0071495	cellular response to endogenous stimulus	368	1035	3.99e-06
GO:BP	GO:0048812	neuron projection morphogenesis	189	479	4.32e-06
GO:BP	GO:0035239	tube morphogenesis	241	638	4.86e-06
GO:BP	GO:0016358	dendrite development	86	183	5.11e-06
GO:BP	GO:0030030	cell projection organization	413	1182	5.18e-06
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	403	1150	5.21e-06
GO:BP	GO:0032989	cellular anatomical entity morphogenesis	224	588	6.50e-06
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	193	494	6.72e-06
GO:BP	GO:0007423	sensory organ development	157	387	7.32e-06
GO:BP	GO:0007264	small GTPase-mediated signal transduction	158	390	7.32e-06
GO:BP	GO:0048858	cell projection morphogenesis	194	498	7.66e-06
GO:BP	GO:0070848	response to growth factor	210	547	8.12e-06
GO:BP	GO:0008360	regulation of cell shape	56	106	8.39e-06
GO:BP	GO:0035295	tube development	287	787	9.83e-06
GO:BP	GO:0071363	cellular response to growth factor stimulus	203	528	1.15e-05
GO:BP	GO:0048589	developmental growth	194	501	1.21e-05
GO:BP	GO:0016043	cellular component organization	1474	4802	1.71e-05
GO:BP	GO:0001568	blood vessel development	201	525	1.85e-05
GO:BP	GO:0071840	cellular component organization or biogenesis	1525	4988	2.56e-05
GO:BP	GO:0001944	vasculature development	209	552	2.69e-05
GO:BP	GO:0001501	skeletal system development	141	347	2.70e-05
GO:BP	GO:0009987	cellular process	3085	10686	4.60e-05
GO:BP	GO:0048514	blood vessel morphogenesis	174	450	5.74e-05
GO:BP	GO:0051130	positive regulation of cellular component organization	302	850	6.39e-05
GO:BP	GO:0009719	response to endogenous stimulus	409	1197	8.00e-05
GO:BP	GO:0044087	regulation of cellular component biogenesis	272	757	8.20e-05
GO:BP	GO:0007417	central nervous system development	252	694	8.20e-05
GO:BP	GO:0048583	regulation of response to stimulus	863	2717	9.18e-05
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	259	717	9.18e-05
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	168	435	9.18e-05
GO:BP	GO:0001525	angiogenesis	150	381	9.59e-05
GO:BP	GO:0001654	eye development	110	263	9.84e-05
GO:BP	GO:0048880	sensory system development	111	266	9.95e-05
GO:BP	GO:0007166	cell surface receptor signaling pathway	591	1801	9.97e-05
GO:BP	GO:0030900	forebrain development	113	272	1.02e-04
GO:BP	GO:1902531	regulation of intracellular signal transduction	436	1289	1.04e-04
GO:BP	GO:0050808	synapse organization	135	337	1.05e-04
GO:BP	GO:0001764	neuron migration	62	129	1.05e-04
GO:BP	GO:0150063	visual system development	110	264	1.14e-04
GO:BP	GO:0045597	positive regulation of cell differentiation	218	591	1.14e-04
GO:BP	GO:0034329	cell junction assembly	130	323	1.19e-04
GO:BP	GO:0060322	head development	201	539	1.26e-04
GO:BP	GO:0014706	striated muscle tissue development	92	213	1.31e-04
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	99	233	1.31e-04
GO:BP	GO:0048738	cardiac muscle tissue development	87	201	2.24e-04
GO:BP	GO:0040007	growth	250	697	2.25e-04
GO:BP	GO:0043010	camera-type eye development	97	230	2.40e-04
GO:BP	GO:0007267	cell-cell signaling	369	1082	2.92e-04
GO:BP	GO:0061061	muscle structure development	198	536	2.94e-04
GO:BP	GO:0031589	cell-substrate adhesion	106	258	3.48e-04
GO:BP	GO:0051093	negative regulation of developmental process	225	622	3.54e-04
GO:BP	GO:0060537	muscle tissue development	133	339	3.96e-04
GO:BP	GO:0007420	brain development	185	498	3.96e-04
GO:BP	GO:0043408	regulation of MAPK cascade	162	427	3.96e-04
GO:BP	GO:0008150	biological_process	3221	11244	4.26e-04
GO:BP	GO:0031346	positive regulation of cell projection organization	115	286	4.46e-04
GO:BP	GO:0048598	embryonic morphogenesis	160	422	4.55e-04
GO:BP	GO:0044057	regulation of system process	147	384	5.96e-04
GO:BP	GO:0007010	cytoskeleton organization	386	1146	5.99e-04
GO:BP	GO:0060284	regulation of cell development	207	570	5.99e-04
GO:BP	GO:0007015	actin filament organization	138	357	6.17e-04
GO:BP	GO:0032970	regulation of actin filament-based process	119	300	6.28e-04
GO:BP	GO:0042221	response to chemical	732	2304	6.28e-04
GO:BP	GO:0021795	cerebral cortex cell migration	22	34	7.57e-04
GO:BP	GO:0030335	positive regulation of cell migration	150	395	7.57e-04
GO:BP	GO:0006468	protein phosphorylation	327	958	8.77e-04
GO:BP	GO:0031345	negative regulation of cell projection organization	65	145	8.77e-04
GO:BP	GO:0048588	developmental cell growth	77	179	9.05e-04
GO:BP	GO:0099536	synaptic signaling	178	483	9.22e-04
GO:BP	GO:0050773	regulation of dendrite development	40	78	9.33e-04
GO:BP	GO:0060041	retina development in camera-type eye	50	105	1.18e-03
GO:BP	GO:0097435	supramolecular fiber organization	225	633	1.19e-03
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	694	2186	1.21e-03
GO:BP	GO:2000147	positive regulation of cell motility	153	408	1.27e-03
GO:BP	GO:0048813	dendrite morphogenesis	52	111	1.39e-03
GO:BP	GO:0050767	regulation of neurogenesis	114	290	1.42e-03
GO:BP	GO:0086003	cardiac muscle cell contraction	34	64	1.51e-03
GO:BP	GO:0051960	regulation of nervous system development	130	339	1.54e-03
GO:BP	GO:0051146	striated muscle cell differentiation	95	234	1.54e-03
GO:BP	GO:0040017	positive regulation of locomotion	155	416	1.60e-03
GO:BP	GO:0000165	MAPK cascade	183	504	1.75e-03
GO:BP	GO:0048705	skeletal system morphogenesis	65	148	1.75e-03
GO:BP	GO:0007409	axonogenesis	129	337	1.78e-03
GO:BP	GO:0030155	regulation of cell adhesion	184	508	1.93e-03
GO:BP	GO:0010976	positive regulation of neuron projection development	58	129	2.00e-03
GO:BP	GO:0051240	positive regulation of multicellular organismal process	349	1040	2.00e-03
GO:BP	GO:0061564	axon development	140	372	2.14e-03
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	167	456	2.22e-03
GO:BP	GO:0048638	regulation of developmental growth	97	243	2.63e-03
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	103	261	2.65e-03
GO:BP	GO:0009967	positive regulation of signal transduction	364	1093	2.69e-03
GO:BP	GO:1990089	response to nerve growth factor	24	41	2.80e-03
GO:BP	GO:1990090	cellular response to nerve growth factor stimulus	24	41	2.80e-03
GO:BP	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	56	125	2.94e-03
GO:BP	GO:0010810	regulation of cell-substrate adhesion	69	162	3.08e-03
GO:BP	GO:0051216	cartilage development	63	145	3.15e-03
GO:BP	GO:0023056	positive regulation of signaling	402	1221	3.17e-03
GO:BP	GO:1990138	neuron projection extension	59	134	3.36e-03
GO:BP	GO:0098609	cell-cell adhesion	200	564	3.42e-03
GO:BP	GO:0010648	negative regulation of cell communication	345	1034	3.42e-03
GO:BP	GO:0070887	cellular response to chemical stimulus	560	1751	3.42e-03
GO:BP	GO:0003007	heart morphogenesis	88	218	3.42e-03
GO:BP	GO:0016049	cell growth	142	382	3.42e-03
GO:BP	GO:0060021	roof of mouth development	35	69	3.46e-03
GO:BP	GO:0086002	cardiac muscle cell action potential involved in contraction	25	44	3.60e-03
GO:BP	GO:0099537	trans-synaptic signaling	169	467	3.73e-03
GO:BP	GO:0043410	positive regulation of MAPK cascade	111	288	3.96e-03
GO:BP	GO:0010647	positive regulation of cell communication	400	1218	3.96e-03
GO:BP	GO:0030048	actin filament-based movement	49	107	3.96e-03
GO:BP	GO:0048592	eye morphogenesis	49	107	3.96e-03
GO:BP	GO:0001667	ameboidal-type cell migration	129	344	4.50e-03
GO:BP	GO:0051049	regulation of transport	363	1098	4.71e-03
GO:BP	GO:0046834	lipid phosphorylation	9	10	4.71e-03
GO:BP	GO:0007268	chemical synaptic transmission	167	463	4.71e-03
GO:BP	GO:0098916	anterograde trans-synaptic signaling	167	463	4.71e-03
GO:BP	GO:0050803	regulation of synapse structure or activity	73	176	4.71e-03
GO:BP	GO:0050807	regulation of synapse organization	72	173	4.71e-03
GO:BP	GO:0023057	negative regulation of signaling	344	1036	4.91e-03
GO:BP	GO:0010632	regulation of epithelial cell migration	77	188	4.97e-03
GO:BP	GO:0003013	circulatory system process	155	426	5.07e-03
GO:BP	GO:0048511	rhythmic process	88	221	5.40e-03
GO:BP	GO:2001222	regulation of neuron migration	22	38	6.20e-03
GO:BP	GO:0050804	modulation of chemical synaptic transmission	121	322	6.27e-03
GO:BP	GO:0022030	telencephalon glial cell migration	14	20	6.55e-03
GO:BP	GO:0021801	cerebral cortex radial glia-guided migration	14	20	6.55e-03
GO:BP	GO:0021885	forebrain cell migration	24	43	6.60e-03
GO:BP	GO:0034762	regulation of transmembrane transport	113	298	6.69e-03
GO:BP	GO:0070372	regulation of ERK1 and ERK2 cascade	72	175	6.69e-03
GO:BP	GO:0007623	circadian rhythm	64	152	7.02e-03
GO:BP	GO:0060560	developmental growth involved in morphogenesis	77	190	7.02e-03
GO:BP	GO:0099177	regulation of trans-synaptic signaling	121	323	7.02e-03
GO:BP	GO:0061448	connective tissue development	82	205	7.26e-03
GO:BP	GO:0021543	pallium development	58	135	7.29e-03
GO:BP	GO:2000146	negative regulation of cell motility	86	217	7.30e-03
GO:BP	GO:0016310	phosphorylation	375	1145	7.58e-03
GO:BP	GO:0022029	telencephalon cell migration	23	41	7.74e-03
GO:BP	GO:0007186	G protein-coupled receptor signaling pathway	141	386	7.74e-03
GO:BP	GO:0043254	regulation of protein-containing complex assembly	122	327	7.74e-03
GO:BP	GO:0035265	organ growth	55	127	8.09e-03
GO:BP	GO:0002062	chondrocyte differentiation	41	88	8.13e-03
GO:BP	GO:0051241	negative regulation of multicellular organismal process	241	706	8.30e-03
GO:BP	GO:0048729	tissue morphogenesis	162	453	8.56e-03
GO:BP	GO:0046328	regulation of JNK cascade	47	105	9.13e-03
GO:BP	GO:0032879	regulation of localization	462	1439	9.27e-03
GO:BP	GO:0060429	epithelium development	267	792	9.27e-03
GO:BP	GO:0006897	endocytosis	174	492	9.41e-03
GO:BP	GO:0090132	epithelium migration	94	243	9.52e-03
GO:BP	GO:0010631	epithelial cell migration	94	243	9.52e-03
GO:BP	GO:0008154	actin polymerization or depolymerization	62	148	9.52e-03
GO:BP	GO:0060998	regulation of dendritic spine development	26	49	9.52e-03
GO:BP	GO:0021537	telencephalon development	78	195	9.52e-03
GO:BP	GO:0030336	negative regulation of cell migration	83	210	9.64e-03
GO:BP	GO:0051179	localization	1129	3731	9.72e-03
GO:BP	GO:0051641	cellular localization	809	2623	1.02e-02
GO:BP	GO:0001503	ossification	113	302	1.08e-02
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	748	2415	1.11e-02
GO:BP	GO:0050877	nervous system process	207	600	1.15e-02
GO:BP	GO:0048675	axon extension	43	95	1.16e-02
GO:BP	GO:0010811	positive regulation of cell-substrate adhesion	43	95	1.16e-02
GO:BP	GO:0060996	dendritic spine development	36	76	1.22e-02
GO:BP	GO:0048568	embryonic organ development	113	303	1.22e-02
GO:BP	GO:0035051	cardiocyte differentiation	56	132	1.22e-02
GO:BP	GO:0070252	actin-mediated cell contraction	40	87	1.24e-02
GO:BP	GO:0051057	positive regulation of small GTPase mediated signal transduction	28	55	1.28e-02
GO:BP	GO:0110053	regulation of actin filament organization	83	212	1.31e-02
GO:BP	GO:0009952	anterior/posterior pattern specification	52	121	1.34e-02
GO:BP	GO:0045785	positive regulation of cell adhesion	112	301	1.40e-02
GO:BP	GO:0071407	cellular response to organic cyclic compound	137	379	1.40e-02
GO:BP	GO:0042692	muscle cell differentiation	119	323	1.44e-02
GO:BP	GO:0045596	negative regulation of cell differentiation	160	452	1.44e-02
GO:BP	GO:0040013	negative regulation of locomotion	93	243	1.44e-02
GO:BP	GO:0030516	regulation of axon extension	35	74	1.45e-02
GO:BP	GO:0007611	learning or memory	75	189	1.51e-02
GO:BP	GO:0021953	central nervous system neuron differentiation	44	99	1.53e-02
GO:BP	GO:0007398	ectoderm development	10	13	1.57e-02
GO:BP	GO:0001508	action potential	45	102	1.58e-02
GO:BP	GO:0099643	signal release from synapse	45	102	1.58e-02
GO:BP	GO:0007269	neurotransmitter secretion	45	102	1.58e-02
GO:BP	GO:0051336	regulation of hydrolase activity	153	431	1.60e-02
GO:BP	GO:0043583	ear development	62	151	1.61e-02
GO:BP	GO:0090130	tissue migration	94	247	1.62e-02
GO:BP	GO:0055007	cardiac muscle cell differentiation	46	105	1.63e-02
GO:BP	GO:0050770	regulation of axonogenesis	53	125	1.64e-02
GO:BP	GO:0043087	regulation of GTPase activity	67	166	1.68e-02
GO:BP	GO:0007411	axon guidance	69	172	1.68e-02
GO:BP	GO:0031401	positive regulation of protein modification process	190	550	1.68e-02
GO:BP	GO:0016192	vesicle-mediated transport	373	1152	1.68e-02
GO:BP	GO:0097485	neuron projection guidance	69	172	1.68e-02
GO:BP	GO:0051017	actin filament bundle assembly	55	131	1.69e-02
GO:BP	GO:0045995	regulation of embryonic development	34	72	1.69e-02
GO:BP	GO:0031032	actomyosin structure organization	73	184	1.69e-02
GO:BP	GO:0055017	cardiac muscle tissue growth	31	64	1.71e-02
GO:BP	GO:0051254	positive regulation of RNA metabolic process	433	1354	1.75e-02
GO:BP	GO:0007610	behavior	149	420	1.85e-02
GO:BP	GO:0018105	peptidyl-serine phosphorylation	65	161	1.93e-02
GO:BP	GO:0061383	trabecula morphogenesis	22	41	1.95e-02
GO:BP	GO:0090596	sensory organ morphogenesis	69	173	1.95e-02
GO:BP	GO:0048617	embryonic foregut morphogenesis	6	6	1.95e-02
GO:BP	GO:0021814	cell motility involved in cerebral cortex radial glia guided migration	6	6	1.95e-02
GO:BP	GO:0065009	regulation of molecular function	416	1299	1.97e-02
GO:BP	GO:0061572	actin filament bundle organization	55	132	2.01e-02
GO:BP	GO:0010033	response to organic substance	545	1736	2.06e-02
GO:BP	GO:0099175	regulation of postsynapse organization	37	81	2.06e-02
GO:BP	GO:0035725	sodium ion transmembrane transport	42	95	2.08e-02
GO:BP	GO:0150115	cell-substrate junction organization	42	95	2.08e-02
GO:BP	GO:0071310	cellular response to organic substance	415	1297	2.11e-02
GO:BP	GO:0086005	ventricular cardiac muscle cell action potential	17	29	2.11e-02
GO:BP	GO:0044089	positive regulation of cellular component biogenesis	139	390	2.15e-02
GO:BP	GO:0050890	cognition	82	213	2.20e-02
GO:BP	GO:0009893	positive regulation of metabolic process	803	2622	2.22e-02
GO:BP	GO:0048593	camera-type eye morphogenesis	39	87	2.27e-02
GO:BP	GO:0007254	JNK cascade	53	127	2.31e-02
GO:BP	GO:0018210	peptidyl-threonine modification	35	76	2.31e-02
GO:BP	GO:0010720	positive regulation of cell development	113	309	2.32e-02
GO:BP	GO:0034220	monoatomic ion transmembrane transport	200	587	2.41e-02
GO:BP	GO:0007612	learning	47	110	2.45e-02
GO:BP	GO:0009968	negative regulation of signal transduction	317	972	2.45e-02
GO:BP	GO:0021987	cerebral cortex development	41	93	2.47e-02
GO:BP	GO:0120033	negative regulation of plasma membrane bounded cell projection assembly	16	27	2.50e-02
GO:BP	GO:0040008	regulation of growth	161	462	2.57e-02
GO:BP	GO:0032271	regulation of protein polymerization	64	160	2.58e-02
GO:BP	GO:0060419	heart growth	33	71	2.59e-02
GO:BP	GO:0018209	peptidyl-serine modification	67	169	2.59e-02
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	395	1234	2.62e-02
GO:BP	GO:0086001	cardiac muscle cell action potential	30	63	2.66e-02
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	394	1231	2.66e-02
GO:BP	GO:0006811	monoatomic ion transport	240	719	2.66e-02
GO:BP	GO:0032231	regulation of actin filament bundle assembly	38	85	2.67e-02
GO:BP	GO:0001954	positive regulation of cell-matrix adhesion	22	42	2.67e-02
GO:BP	GO:0007517	muscle organ development	99	267	2.72e-02
GO:BP	GO:0030001	metal ion transport	180	524	2.72e-02
GO:BP	GO:0007044	cell-substrate junction assembly	39	88	2.78e-02
GO:BP	GO:0006814	sodium ion transport	56	137	2.81e-02
GO:BP	GO:0098657	import into cell	210	622	2.86e-02
GO:BP	GO:0035025	positive regulation of Rho protein signal transduction	15	25	2.90e-02
GO:BP	GO:0070374	positive regulation of ERK1 and ERK2 cascade	47	111	2.91e-02
GO:BP	GO:0014070	response to organic cyclic compound	205	606	2.91e-02
GO:BP	GO:0051234	establishment of localization	979	3240	2.92e-02
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	238	714	2.92e-02
GO:BP	GO:0006898	receptor-mediated endocytosis	71	182	2.93e-02
GO:BP	GO:0018107	peptidyl-threonine phosphorylation	32	69	3.03e-02
GO:BP	GO:0003281	ventricular septum development	32	69	3.03e-02
GO:BP	GO:0050709	negative regulation of protein secretion	23	45	3.04e-02
GO:BP	GO:0019722	calcium-mediated signaling	51	123	3.11e-02
GO:BP	GO:0140352	export from cell	201	594	3.12e-02
GO:BP	GO:0042592	homeostatic process	365	1137	3.12e-02
GO:BP	GO:0048546	digestive tract morphogenesis	17	30	3.13e-02
GO:BP	GO:0060323	head morphogenesis	17	30	3.13e-02
GO:BP	GO:0060065	uterus development	10	14	3.13e-02
GO:BP	GO:0002363	alpha-beta T cell lineage commitment	10	14	3.13e-02
GO:BP	GO:0060412	ventricular septum morphogenesis	21	40	3.14e-02
GO:BP	GO:0055013	cardiac muscle cell development	33	72	3.17e-02
GO:BP	GO:0086091	regulation of heart rate by cardiac conduction	19	35	3.18e-02
GO:BP	GO:0003012	muscle system process	117	325	3.21e-02
GO:BP	GO:0038203	TORC2 signaling	8	10	3.21e-02
GO:BP	GO:0045176	apical protein localization	9	12	3.25e-02
GO:BP	GO:0032486	Rap protein signal transduction	9	12	3.25e-02
GO:BP	GO:0046339	diacylglycerol metabolic process	14	23	3.30e-02
GO:BP	GO:0010977	negative regulation of neuron projection development	46	109	3.30e-02
GO:BP	GO:0050772	positive regulation of axonogenesis	30	64	3.30e-02
GO:BP	GO:1901888	regulation of cell junction assembly	62	156	3.30e-02
GO:BP	GO:0009892	negative regulation of metabolic process	648	2100	3.31e-02
GO:BP	GO:0010718	positive regulation of epithelial to mesenchymal transition	24	48	3.33e-02
GO:BP	GO:0030198	extracellular matrix organization	84	223	3.45e-02
GO:BP	GO:0030832	regulation of actin filament length	49	118	3.49e-02
GO:BP	GO:0060411	cardiac septum morphogenesis	31	67	3.52e-02
GO:BP	GO:1902903	regulation of supramolecular fiber organization	110	304	3.52e-02
GO:BP	GO:0051493	regulation of cytoskeleton organization	144	412	3.57e-02
GO:BP	GO:0030041	actin filament polymerization	51	124	3.57e-02
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	92	248	3.57e-02
GO:BP	GO:0010634	positive regulation of epithelial cell migration	52	127	3.60e-02
GO:BP	GO:0044319	wound healing, spreading of cells	16	28	3.62e-02
GO:BP	GO:0090505	epiboly involved in wound healing	16	28	3.62e-02
GO:BP	GO:0048839	inner ear development	54	133	3.65e-02
GO:BP	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	70	181	3.72e-02
GO:BP	GO:0006810	transport	903	2984	3.72e-02
GO:BP	GO:0032924	activin receptor signaling pathway	18	33	3.72e-02
GO:BP	GO:0050769	positive regulation of neurogenesis	71	184	3.72e-02
GO:BP	GO:0007160	cell-matrix adhesion	66	169	3.75e-02
GO:BP	GO:0120032	regulation of plasma membrane bounded cell projection assembly	62	157	3.75e-02
GO:BP	GO:0043062	extracellular structure organization	84	224	3.81e-02
GO:BP	GO:0045229	external encapsulating structure organization	84	224	3.81e-02
GO:BP	GO:0110020	regulation of actomyosin structure organization	38	87	3.82e-02
GO:BP	GO:0010586	miRNA metabolic process	38	87	3.82e-02
GO:BP	GO:0051247	positive regulation of protein metabolic process	296	911	3.83e-02
GO:BP	GO:0051962	positive regulation of nervous system development	80	212	3.93e-02
GO:BP	GO:0003407	neural retina development	23	46	3.93e-02
GO:BP	GO:0031324	negative regulation of cellular metabolic process	598	1934	4.04e-02
GO:BP	GO:0070371	ERK1 and ERK2 cascade	74	194	4.12e-02
GO:BP	GO:1903522	regulation of blood circulation	74	194	4.12e-02
GO:BP	GO:0003170	heart valve development	30	65	4.12e-02
GO:BP	GO:0010171	body morphogenesis	21	41	4.20e-02
GO:BP	GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	95	259	4.21e-02
GO:BP	GO:0002761	regulation of myeloid leukocyte differentiation	35	79	4.21e-02
GO:BP	GO:0045444	fat cell differentiation	69	179	4.22e-02
GO:BP	GO:0097484	dendrite extension	15	26	4.22e-02
GO:BP	GO:0021799	cerebral cortex radially oriented cell migration	15	26	4.22e-02
GO:BP	GO:0098655	monoatomic cation transmembrane transport	169	495	4.28e-02
GO:BP	GO:0008015	blood circulation	126	357	4.29e-02
GO:BP	GO:0002360	T cell lineage commitment	12	19	4.29e-02
GO:BP	GO:0032233	positive regulation of actin filament bundle assembly	24	49	4.29e-02
GO:BP	GO:0098660	inorganic ion transmembrane transport	177	521	4.29e-02
GO:BP	GO:0030833	regulation of actin filament polymerization	43	102	4.30e-02
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	79	210	4.43e-02
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	284	874	4.50e-02
GO:BP	GO:0051345	positive regulation of hydrolase activity	97	266	4.53e-02
GO:BP	GO:0072659	protein localization to plasma membrane	88	238	4.53e-02
GO:BP	GO:0033036	macromolecule localization	706	2309	4.63e-02
GO:BP	GO:0008064	regulation of actin polymerization or depolymerization	48	117	4.66e-02
GO:BP	GO:0002042	cell migration involved in sprouting angiogenesis	22	44	4.66e-02
GO:BP	GO:0042391	regulation of membrane potential	102	282	4.67e-02
GO:BP	GO:0007163	establishment or maintenance of cell polarity	70	183	4.73e-02
GO:BP	GO:0018193	peptidyl-amino acid modification	187	555	4.74e-02
GO:BP	GO:0003186	tricuspid valve morphogenesis	5	5	4.77e-02
GO:BP	GO:0006836	neurotransmitter transport	54	135	4.77e-02
GO:BP	GO:0061038	uterus morphogenesis	5	5	4.77e-02
GO:BP	GO:0021815	modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration	5	5	4.77e-02
GO:BP	GO:0097061	dendritic spine organization	29	63	4.77e-02
GO:BP	GO:0035696	monocyte extravasation	5	5	4.77e-02
GO:BP	GO:0048878	chemical homeostasis	222	670	4.77e-02
GO:BP	GO:0045637	regulation of myeloid cell differentiation	54	135	4.77e-02
GO:BP	GO:1905274	regulation of modification of postsynaptic actin cytoskeleton	5	5	4.77e-02
GO:BP	GO:1902905	positive regulation of supramolecular fiber organization	55	138	4.78e-02
GO:BP	GO:0060491	regulation of cell projection assembly	62	159	4.78e-02
GO:BP	GO:0099173	postsynapse organization	58	147	4.79e-02
GO:BP	GO:0035313	wound healing, spreading of epidermal cells	11	17	4.79e-02
GO:BP	GO:0051492	regulation of stress fiber assembly	34	77	4.79e-02
GO:BP	GO:0048048	embryonic eye morphogenesis	14	24	4.84e-02
GO:BP	GO:0044093	positive regulation of molecular function	256	783	4.91e-02
GO:BP	GO:0003179	heart valve morphogenesis	26	55	4.95e-02
GO:BP	GO:0007389	pattern specification process	103	286	4.96e-02

EARnomtable_20k %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in EAR neargenes_20k") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in EAR neargenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:04510	Focal adhesion	79	169	5.32e-05
KEGG	KEGG:04015	Rap1 signaling pathway	73	162	4.35e-04
KEGG	KEGG:04520	Adherens junction	42	83	1.27e-03
KEGG	KEGG:04310	Wnt signaling pathway	58	133	6.21e-03
KEGG	KEGG:05205	Proteoglycans in cancer	68	162	6.21e-03
KEGG	KEGG:04360	Axon guidance	65	155	7.57e-03
KEGG	KEGG:04713	Circadian entrainment	33	68	1.29e-02
KEGG	KEGG:03013	Nucleocytoplasmic transport	43	96	1.40e-02
KEGG	KEGG:05100	Bacterial invasion of epithelial cells	34	73	2.14e-02
KEGG	KEGG:04512	ECM-receptor interaction	31	66	2.78e-02
KEGG	KEGG:04530	Tight junction	53	129	2.94e-02
KEGG	KEGG:04928	Parathyroid hormone synthesis, secretion and action	35	78	3.11e-02
KEGG	KEGG:04720	Long-term potentiation	25	51	3.12e-02
KEGG	KEGG:00561	Glycerolipid metabolism	22	44	4.07e-02
KEGG	KEGG:04730	Long-term depression	20	39	4.12e-02
KEGG	KEGG:04974	Protein digestion and absorption	26	56	4.54e-02
KEGG	KEGG:05412	Arrhythmogenic right ventricular cardiomyopathy	30	67	4.54e-02
KEGG	KEGG:04921	Oxytocin signaling pathway	46	113	4.54e-02
KEGG	KEGG:04742	Taste transduction	12	20	4.54e-02
KEGG	KEGG:05200	Pathways in cancer	135	391	4.54e-02
KEGG	KEGG:04072	Phospholipase D signaling pathway	44	107	4.54e-02

EAR peaks overlapping enhancers

# EAR_resgenes_20k_enh <- gost(query = unique(EAR_enh_peaks_20k$NCBI_gene),
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(EAR_resgenes_20k_enh,"data/GO_KEGG_analysis/EAR_resgenes_20k_enh.RDS")


# EARnom <- gostplot(EAR_resgenes_20k_enh, capped = FALSE, interactive = TRUE)
# EARnom

EARnomtable_20k_enh <- EAR_resgenes_20k_enh$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

EARnomtable_20k_enh %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in EAR enhancer neargenes_20k" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in EAR enhancer neargenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0050789	regulation of biological process	579	7516	8.40e-13
GO:BP	GO:0050794	regulation of cellular process	556	7153	1.41e-12
GO:BP	GO:0065007	biological regulation	587	7734	5.33e-12
GO:BP	GO:0048522	positive regulation of cellular process	344	3954	1.64e-10
GO:BP	GO:0048518	positive regulation of biological process	366	4301	2.84e-10
GO:BP	GO:0051254	positive regulation of RNA metabolic process	146	1354	1.67e-08
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	135	1231	3.06e-08
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	135	1234	3.18e-08
GO:BP	GO:0048523	negative regulation of cellular process	304	3550	5.73e-08
GO:BP	GO:0048519	negative regulation of biological process	318	3764	7.00e-08
GO:BP	GO:0032502	developmental process	339	4179	1.68e-06
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	171	1791	1.77e-06
GO:BP	GO:0050793	regulation of developmental process	164	1697	1.77e-06
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	150	1514	1.77e-06
GO:BP	GO:0009653	anatomical structure morphogenesis	174	1844	2.80e-06
GO:BP	GO:0048856	anatomical structure development	316	3867	3.01e-06
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	173	1841	3.77e-06
GO:BP	GO:0009891	positive regulation of biosynthetic process	174	1856	3.79e-06
GO:BP	GO:0051252	regulation of RNA metabolic process	230	2663	1.11e-05
GO:BP	GO:0051128	regulation of cellular component organization	172	1862	1.25e-05
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	166	1787	1.51e-05
GO:BP	GO:0009893	positive regulation of metabolic process	226	2622	1.60e-05
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	194	2186	2.42e-05
GO:BP	GO:0006366	transcription by RNA polymerase II	171	1879	3.04e-05
GO:BP	GO:0048869	cellular developmental process	237	2804	3.04e-05
GO:BP	GO:0030154	cell differentiation	237	2803	3.04e-05
GO:BP	GO:0006355	regulation of DNA-templated transcription	209	2410	3.31e-05
GO:BP	GO:0032501	multicellular organismal process	351	4504	3.63e-05
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	209	2415	3.63e-05
GO:BP	GO:2001141	regulation of RNA biosynthetic process	209	2422	4.41e-05
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	311	3918	5.45e-05
GO:BP	GO:0031325	positive regulation of cellular metabolic process	202	2333	5.65e-05
GO:BP	GO:0006351	DNA-templated transcription	214	2510	6.90e-05
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	281	3486	7.41e-05
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	92	874	8.52e-05
GO:BP	GO:0007275	multicellular organism development	259	3170	8.66e-05
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	240	2895	8.81e-05
GO:BP	GO:0010468	regulation of gene expression	273	3379	8.99e-05
GO:BP	GO:0080090	regulation of primary metabolic process	315	4015	1.10e-04
GO:BP	GO:0032774	RNA biosynthetic process	214	2533	1.10e-04
GO:BP	GO:0040007	growth	77	697	1.10e-04
GO:BP	GO:0048731	system development	227	2719	1.10e-04
GO:BP	GO:0031326	regulation of cellular biosynthetic process	285	3569	1.11e-04
GO:BP	GO:0009889	regulation of biosynthetic process	286	3595	1.42e-04
GO:BP	GO:0051239	regulation of multicellular organismal process	170	1924	1.42e-04
GO:BP	GO:0031324	negative regulation of cellular metabolic process	170	1934	1.90e-04
GO:BP	GO:0009890	negative regulation of biosynthetic process	148	1635	2.08e-04
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	147	1624	2.23e-04
GO:BP	GO:0050896	response to stimulus	401	5379	2.36e-04
GO:BP	GO:0072359	circulatory system development	89	864	2.36e-04
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	144	1588	2.49e-04
GO:BP	GO:0141124	intracellular signaling cassette	123	1314	3.34e-04
GO:BP	GO:0009987	cellular process	713	10686	3.95e-04
GO:BP	GO:0060255	regulation of macromolecule metabolic process	325	4231	3.95e-04
GO:BP	GO:0019222	regulation of metabolic process	349	4603	4.36e-04
GO:BP	GO:0008150	biological_process	741	11244	5.30e-04
GO:BP	GO:0009892	negative regulation of metabolic process	179	2100	5.42e-04
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	110	1157	5.42e-04
GO:BP	GO:0051253	negative regulation of RNA metabolic process	103	1067	5.71e-04
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	232	2867	6.18e-04
GO:BP	GO:0010586	miRNA metabolic process	18	87	6.29e-04
GO:BP	GO:0071310	cellular response to organic substance	120	1297	6.70e-04
GO:BP	GO:0031323	regulation of cellular metabolic process	323	4233	7.16e-04
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	66	609	8.43e-04
GO:BP	GO:0001568	blood vessel development	59	525	8.47e-04
GO:BP	GO:0051094	positive regulation of developmental process	90	913	9.42e-04
GO:BP	GO:0001944	vasculature development	61	552	9.79e-04
GO:BP	GO:0010033	response to organic substance	151	1736	1.06e-03
GO:BP	GO:0051716	cellular response to stimulus	348	4640	1.11e-03
GO:BP	GO:0043408	regulation of MAPK cascade	50	427	1.28e-03
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	143	1633	1.30e-03
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	93	965	1.50e-03
GO:BP	GO:0048589	developmental growth	56	501	1.50e-03
GO:BP	GO:0010648	negative regulation of cell communication	98	1034	1.69e-03
GO:BP	GO:0071495	cellular response to endogenous stimulus	98	1035	1.73e-03
GO:BP	GO:0023052	signaling	299	3918	1.79e-03
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	93	973	1.92e-03
GO:BP	GO:0007154	cell communication	303	3983	1.92e-03
GO:BP	GO:0018130	heterocycle biosynthetic process	232	2927	2.12e-03
GO:BP	GO:0019438	aromatic compound biosynthetic process	232	2928	2.15e-03
GO:BP	GO:0060419	heart growth	15	71	2.15e-03
GO:BP	GO:0040008	regulation of growth	52	462	2.22e-03
GO:BP	GO:0061061	muscle structure development	58	536	2.42e-03
GO:BP	GO:0055017	cardiac muscle tissue growth	14	64	2.53e-03
GO:BP	GO:0023057	negative regulation of signaling	97	1036	2.63e-03
GO:BP	GO:0048468	cell development	159	1886	2.63e-03
GO:BP	GO:0016477	cell migration	95	1011	2.67e-03
GO:BP	GO:0009719	response to endogenous stimulus	109	1197	2.67e-03
GO:BP	GO:0016043	cellular component organization	355	4802	2.67e-03
GO:BP	GO:0000165	MAPK cascade	55	504	2.84e-03
GO:BP	GO:0048513	animal organ development	167	2004	2.85e-03
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	163	1951	3.09e-03
GO:BP	GO:0035556	intracellular signal transduction	163	1951	3.09e-03
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	237	3026	3.23e-03
GO:BP	GO:0010646	regulation of cell communication	197	2444	3.50e-03
GO:BP	GO:0048514	blood vessel morphogenesis	50	450	3.76e-03
GO:BP	GO:0035295	tube development	77	787	3.79e-03
GO:BP	GO:1902895	positive regulation of miRNA transcription	11	44	4.08e-03
GO:BP	GO:0016070	RNA metabolic process	258	3352	4.08e-03
GO:BP	GO:0023051	regulation of signaling	196	2438	4.08e-03
GO:BP	GO:0001525	angiogenesis	44	381	4.08e-03
GO:BP	GO:0016049	cell growth	44	382	4.22e-03
GO:BP	GO:0071840	cellular component organization or biogenesis	365	4988	4.22e-03
GO:BP	GO:1902893	regulation of miRNA transcription	13	60	4.24e-03
GO:BP	GO:0007165	signal transduction	275	3611	4.24e-03
GO:BP	GO:0060644	mammary gland epithelial cell differentiation	6	13	4.24e-03
GO:BP	GO:2000026	regulation of multicellular organismal development	89	951	4.62e-03
GO:BP	GO:0061614	miRNA transcription	13	61	4.94e-03
GO:BP	GO:0042221	response to chemical	186	2304	4.94e-03
GO:BP	GO:0046328	regulation of JNK cascade	18	105	4.99e-03
GO:BP	GO:0070887	cellular response to chemical stimulus	147	1751	5.34e-03
GO:BP	GO:0048870	cell motility	101	1120	6.04e-03
GO:BP	GO:0010842	retina layer formation	6	14	6.58e-03
GO:BP	GO:2000628	regulation of miRNA metabolic process	14	72	7.29e-03
GO:BP	GO:0051130	positive regulation of cellular component organization	80	850	8.39e-03
GO:BP	GO:0033500	carbohydrate homeostasis	24	170	8.62e-03
GO:BP	GO:0001678	intracellular glucose homeostasis	18	110	8.69e-03
GO:BP	GO:0051641	cellular localization	206	2623	8.73e-03
GO:BP	GO:2000145	regulation of cell motility	68	700	1.04e-02
GO:BP	GO:0035239	tube morphogenesis	63	638	1.14e-02
GO:BP	GO:2000630	positive regulation of miRNA metabolic process	11	50	1.15e-02
GO:BP	GO:0048699	generation of neurons	96	1076	1.22e-02
GO:BP	GO:0097240	chromosome attachment to the nuclear envelope	3	3	1.27e-02
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	78	837	1.29e-02
GO:BP	GO:0040012	regulation of locomotion	69	720	1.32e-02
GO:BP	GO:0006325	chromatin organization	60	604	1.32e-02
GO:BP	GO:0001558	regulation of cell growth	37	323	1.38e-02
GO:BP	GO:0060041	retina development in camera-type eye	17	105	1.38e-02
GO:BP	GO:0030182	neuron differentiation	91	1014	1.38e-02
GO:BP	GO:0061117	negative regulation of heart growth	6	16	1.38e-02
GO:BP	GO:0055022	negative regulation of cardiac muscle tissue growth	6	16	1.38e-02
GO:BP	GO:0042592	homeostatic process	100	1137	1.40e-02
GO:BP	GO:0051179	localization	278	3731	1.50e-02
GO:BP	GO:0035265	organ growth	19	127	1.67e-02
GO:BP	GO:0042593	glucose homeostasis	23	169	1.73e-02
GO:BP	GO:0014706	striated muscle tissue development	27	213	1.79e-02
GO:BP	GO:0030029	actin filament-based process	62	640	1.87e-02
GO:BP	GO:0032879	regulation of localization	121	1439	1.87e-02
GO:BP	GO:0030334	regulation of cell migration	64	668	2.00e-02
GO:BP	GO:0060044	negative regulation of cardiac muscle cell proliferation	4	7	2.09e-02
GO:BP	GO:0060159	regulation of dopamine receptor signaling pathway	4	7	2.09e-02
GO:BP	GO:0071824	protein-DNA complex organization	65	683	2.12e-02
GO:BP	GO:0022008	neurogenesis	107	1251	2.21e-02
GO:BP	GO:0045595	regulation of cell differentiation	94	1073	2.26e-02
GO:BP	GO:0031346	positive regulation of cell projection organization	33	286	2.27e-02
GO:BP	GO:0045926	negative regulation of growth	24	184	2.27e-02
GO:BP	GO:0040011	locomotion	74	805	2.34e-02
GO:BP	GO:0050772	positive regulation of axonogenesis	12	64	2.37e-02
GO:BP	GO:0009725	response to hormone	59	610	2.46e-02
GO:BP	GO:0033993	response to lipid	56	573	2.61e-02
GO:BP	GO:1901700	response to oxygen-containing compound	95	1093	2.61e-02
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	260	3495	2.61e-02
GO:BP	GO:0097306	cellular response to alcohol	13	74	2.63e-02
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	45	435	2.65e-02
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	66	704	2.65e-02
GO:BP	GO:0009968	negative regulation of signal transduction	86	972	2.68e-02
GO:BP	GO:0014741	negative regulation of muscle hypertrophy	7	25	2.69e-02
GO:BP	GO:0033036	macromolecule localization	180	2309	2.85e-02
GO:BP	GO:0060537	muscle tissue development	37	339	2.87e-02
GO:BP	GO:0009966	regulation of signal transduction	170	2166	3.01e-02
GO:BP	GO:0048878	chemical homeostasis	63	670	3.12e-02
GO:BP	GO:0071363	cellular response to growth factor stimulus	52	528	3.15e-02
GO:BP	GO:0048738	cardiac muscle tissue development	25	201	3.20e-02
GO:BP	GO:0031344	regulation of cell projection organization	51	516	3.22e-02
GO:BP	GO:0006810	transport	225	2984	3.23e-02
GO:BP	GO:0051726	regulation of cell cycle	79	885	3.24e-02
GO:BP	GO:0048583	regulation of response to stimulus	207	2717	3.28e-02
GO:BP	GO:0010975	regulation of neuron projection development	38	355	3.35e-02
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	50	505	3.37e-02
GO:BP	GO:1903294	regulation of glutamate secretion, neurotransmission	3	4	3.51e-02
GO:BP	GO:0007254	JNK cascade	18	127	3.56e-02
GO:BP	GO:0007015	actin filament organization	38	357	3.64e-02
GO:BP	GO:0072659	protein localization to plasma membrane	28	238	3.66e-02
GO:BP	GO:0070848	response to growth factor	53	547	3.81e-02
GO:BP	GO:0007399	nervous system development	142	1775	3.82e-02
GO:BP	GO:0032880	regulation of protein localization	64	691	3.82e-02
GO:BP	GO:0043933	protein-containing complex organization	148	1863	3.91e-02
GO:BP	GO:0048661	positive regulation of smooth muscle cell proliferation	11	60	4.01e-02
GO:BP	GO:1990778	protein localization to cell periphery	32	287	4.01e-02
GO:BP	GO:2000045	regulation of G1/S transition of mitotic cell cycle	19	140	4.17e-02
GO:BP	GO:0006338	chromatin remodeling	48	486	4.17e-02
GO:BP	GO:0043410	positive regulation of MAPK cascade	32	288	4.17e-02
GO:BP	GO:0007266	Rho protein signal transduction	16	109	4.28e-02
GO:BP	GO:0090304	nucleic acid metabolic process	276	3777	4.28e-02
GO:BP	GO:0045597	positive regulation of cell differentiation	56	591	4.40e-02
GO:BP	GO:0030307	positive regulation of cell growth	17	120	4.50e-02
GO:BP	GO:0033002	muscle cell proliferation	20	152	4.50e-02
GO:BP	GO:0140747	regulation of ncRNA transcription	13	80	4.56e-02
GO:BP	GO:0048638	regulation of developmental growth	28	243	4.61e-02
GO:BP	GO:0070372	regulation of ERK1 and ERK2 cascade	22	175	4.78e-02
GO:BP	GO:0007264	small GTPase-mediated signal transduction	40	390	4.91e-02
GO:BP	GO:0051240	positive regulation of multicellular organismal process	89	1040	4.91e-02
GO:BP	GO:0048511	rhythmic process	26	221	4.91e-02
GO:BP	GO:0048103	somatic stem cell division	4	9	4.91e-02
GO:BP	GO:0034380	high-density lipoprotein particle assembly	4	9	4.91e-02
GO:BP	GO:0051093	negative regulation of developmental process	58	622	4.98e-02

EARnomtable_20k_enh %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in EAR enhancer neargenes_20k") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in EAR enhancer neargenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:05203	Viral carcinogenesis	22	142	2.18e-02
KEGG	KEGG:05205	Proteoglycans in cancer	23	162	2.93e-02

ESR 20,000 bp NG

# ESR_resgenes_20k <- gost(query = ESR_peak_list_20k$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(ESR_resgenes_20k,"data/GO_KEGG_analysis/ESR_resgenes_20k.RDS")


# ESRnom <- gostplot(ESR_resgenes_20k, capped = FALSE, interactive = TRUE)
# ESRnom

ESRnomtable_20k <- ESR_resgenes_20k$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

ESRnomtable_20k %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in ESR nESRgenes_20k" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in ESR nESRgenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0032501	multicellular organismal process	2259	4504	1.68e-50
GO:BP	GO:0048856	anatomical structure development	1964	3867	6.68e-46
GO:BP	GO:0009653	anatomical structure morphogenesis	1034	1844	9.73e-42
GO:BP	GO:0007154	cell communication	1992	3983	9.85e-41
GO:BP	GO:0023052	signaling	1962	3918	2.10e-40
GO:BP	GO:0007275	multicellular organism development	1633	3170	2.57e-40
GO:BP	GO:0032502	developmental process	2072	4179	6.91e-40
GO:BP	GO:0048731	system development	1424	2719	1.37e-38
GO:BP	GO:0050896	response to stimulus	2549	5379	2.99e-33
GO:BP	GO:0030154	cell differentiation	1438	2803	6.60e-33
GO:BP	GO:0007165	signal transduction	1794	3611	6.60e-33
GO:BP	GO:0048869	cellular developmental process	1438	2804	7.71e-33
GO:BP	GO:0051716	cellular response to stimulus	2225	4640	8.80e-31
GO:BP	GO:0051239	regulation of multicellular organismal process	1024	1924	4.99e-29
GO:BP	GO:0007399	nervous system development	953	1775	1.85e-28
GO:BP	GO:0007155	cell adhesion	553	941	2.52e-27
GO:BP	GO:0048468	cell development	998	1886	5.84e-27
GO:BP	GO:0009888	tissue development	746	1348	1.66e-26
GO:BP	GO:0048513	animal organ development	1049	2004	2.68e-26
GO:BP	GO:0050793	regulation of developmental process	899	1697	5.03e-24
GO:BP	GO:0010646	regulation of cell communication	1236	2444	7.74e-24
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	491	837	8.49e-24
GO:BP	GO:0023051	regulation of signaling	1231	2438	2.18e-23
GO:BP	GO:0007166	cell surface receptor signaling pathway	943	1801	3.18e-23
GO:BP	GO:0048870	cell motility	625	1120	5.48e-23
GO:BP	GO:0003008	system process	633	1139	1.04e-22
GO:BP	GO:0016477	cell migration	571	1011	1.80e-22
GO:BP	GO:0022008	neurogenesis	684	1251	3.30e-22
GO:BP	GO:0032989	cellular anatomical entity morphogenesis	360	588	1.80e-21
GO:BP	GO:0000902	cell morphogenesis	421	713	5.94e-21
GO:BP	GO:0030029	actin filament-based process	384	640	1.02e-20
GO:BP	GO:0034330	cell junction organization	336	545	1.10e-20
GO:BP	GO:0048699	generation of neurons	594	1076	2.83e-20
GO:BP	GO:0035239	tube morphogenesis	381	638	4.70e-20
GO:BP	GO:0141124	intracellular signaling cassette	704	1314	7.30e-20
GO:BP	GO:0050789	regulation of biological process	3343	7516	8.62e-20
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	365	609	1.49e-19
GO:BP	GO:0035295	tube development	452	787	2.39e-19
GO:BP	GO:0030182	neuron differentiation	560	1014	4.37e-19
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	416	717	8.67e-19
GO:BP	GO:0031175	neuron projection development	428	743	1.40e-18
GO:BP	GO:0009887	animal organ morphogenesis	392	673	4.88e-18
GO:BP	GO:0007267	cell-cell signaling	588	1082	4.88e-18
GO:BP	GO:0048666	neuron development	472	838	5.11e-18
GO:BP	GO:0051240	positive regulation of multicellular organismal process	568	1040	5.36e-18
GO:BP	GO:0065007	biological regulation	3418	7734	5.47e-18
GO:BP	GO:0072359	circulatory system development	483	864	1.26e-17
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	618	1150	1.28e-17
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	301	494	1.95e-17
GO:BP	GO:0048858	cell projection morphogenesis	303	498	1.95e-17
GO:BP	GO:0030036	actin cytoskeleton organization	337	566	2.06e-17
GO:BP	GO:0048729	tissue morphogenesis	280	453	2.16e-17
GO:BP	GO:0050794	regulation of cellular process	3179	7153	3.02e-17
GO:BP	GO:0030030	cell projection organization	631	1182	3.34e-17
GO:BP	GO:0044057	regulation of system process	243	384	8.34e-17
GO:BP	GO:2000026	regulation of multicellular organismal development	521	951	8.81e-17
GO:BP	GO:0009966	regulation of signal transduction	1073	2166	1.71e-16
GO:BP	GO:0065008	regulation of biological quality	951	1893	1.99e-16
GO:BP	GO:0040011	locomotion	449	805	4.21e-16
GO:BP	GO:0048812	neuron projection morphogenesis	289	479	6.47e-16
GO:BP	GO:2000145	regulation of cell motility	396	700	2.18e-15
GO:BP	GO:0035556	intracellular signal transduction	971	1951	2.43e-15
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	265	435	2.80e-15
GO:BP	GO:0051094	positive regulation of developmental process	497	913	2.86e-15
GO:BP	GO:0001568	blood vessel development	310	525	2.86e-15
GO:BP	GO:0030334	regulation of cell migration	380	668	2.87e-15
GO:BP	GO:0048518	positive regulation of biological process	1986	4301	2.87e-15
GO:BP	GO:0001944	vasculature development	323	552	3.52e-15
GO:BP	GO:0048522	positive regulation of cellular process	1838	3954	3.99e-15
GO:BP	GO:0048583	regulation of response to stimulus	1306	2717	4.82e-15
GO:BP	GO:0051128	regulation of cellular component organization	929	1862	5.69e-15
GO:BP	GO:0040012	regulation of locomotion	403	720	1.04e-14
GO:BP	GO:0071495	cellular response to endogenous stimulus	551	1035	1.49e-14
GO:BP	GO:0003013	circulatory system process	258	426	1.85e-14
GO:BP	GO:0048514	blood vessel morphogenesis	270	450	1.92e-14
GO:BP	GO:0060485	mesenchyme development	164	245	2.02e-14
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	297	505	2.52e-14
GO:BP	GO:0031344	regulation of cell projection organization	302	516	3.45e-14
GO:BP	GO:0007010	cytoskeleton organization	599	1146	7.99e-14
GO:BP	GO:0098609	cell-cell adhesion	324	564	1.03e-13
GO:BP	GO:0034329	cell junction assembly	203	323	1.48e-13
GO:BP	GO:0045595	regulation of cell differentiation	563	1073	2.56e-13
GO:BP	GO:0048519	negative regulation of biological process	1743	3764	3.34e-13
GO:BP	GO:0009719	response to endogenous stimulus	619	1197	4.04e-13
GO:BP	GO:0008015	blood circulation	219	357	4.97e-13
GO:BP	GO:0060429	epithelium development	430	792	7.30e-13
GO:BP	GO:0098657	import into cell	349	622	7.61e-13
GO:BP	GO:0030001	metal ion transport	301	524	1.07e-12
GO:BP	GO:0010975	regulation of neuron projection development	217	355	1.10e-12
GO:BP	GO:0030155	regulation of cell adhesion	293	508	1.19e-12
GO:BP	GO:0051049	regulation of transport	571	1098	1.34e-12
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	267	456	1.60e-12
GO:BP	GO:0003012	muscle system process	201	325	1.96e-12
GO:BP	GO:0070848	response to growth factor	310	547	4.47e-12
GO:BP	GO:0009790	embryo development	440	821	5.10e-12
GO:BP	GO:0071363	cellular response to growth factor stimulus	300	528	7.44e-12
GO:BP	GO:0048523	negative regulation of cellular process	1641	3550	8.41e-12
GO:BP	GO:0007409	axonogenesis	205	337	1.12e-11
GO:BP	GO:0002009	morphogenesis of an epithelium	221	369	1.22e-11
GO:BP	GO:0031589	cell-substrate adhesion	164	258	1.71e-11
GO:BP	GO:0045597	positive regulation of cell differentiation	329	591	1.72e-11
GO:BP	GO:0051960	regulation of nervous system development	205	339	2.48e-11
GO:BP	GO:0048762	mesenchymal cell differentiation	133	200	2.48e-11
GO:BP	GO:0001525	angiogenesis	226	381	2.51e-11
GO:BP	GO:0150115	cell-substrate junction organization	74	95	2.51e-11
GO:BP	GO:0042221	response to chemical	1100	2304	3.45e-11
GO:BP	GO:0007264	small GTPase-mediated signal transduction	230	390	3.54e-11
GO:BP	GO:0061564	axon development	221	372	3.60e-11
GO:BP	GO:0010810	regulation of cell-substrate adhesion	112	162	3.60e-11
GO:BP	GO:0044087	regulation of cellular component biogenesis	406	757	4.04e-11
GO:BP	GO:0048589	developmental growth	284	501	4.53e-11
GO:BP	GO:0048598	embryonic morphogenesis	245	422	6.14e-11
GO:BP	GO:0061061	muscle structure development	300	536	7.98e-11
GO:BP	GO:0007044	cell-substrate junction assembly	69	88	8.49e-11
GO:BP	GO:0070588	calcium ion transmembrane transport	137	210	8.88e-11
GO:BP	GO:0051241	negative regulation of multicellular organismal process	380	706	1.21e-10
GO:BP	GO:0006936	muscle contraction	160	255	1.42e-10
GO:BP	GO:0007186	G protein-coupled receptor signaling pathway	226	386	1.45e-10
GO:BP	GO:0006816	calcium ion transport	163	262	2.41e-10
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	148	233	2.42e-10
GO:BP	GO:0034762	regulation of transmembrane transport	181	298	3.17e-10
GO:BP	GO:0010647	positive regulation of cell communication	613	1218	3.24e-10
GO:BP	GO:0023056	positive regulation of signaling	614	1221	3.73e-10
GO:BP	GO:0008285	negative regulation of cell population proliferation	265	469	4.14e-10
GO:BP	GO:0023057	negative regulation of signaling	529	1036	6.12e-10
GO:BP	GO:0099536	synaptic signaling	271	483	6.68e-10
GO:BP	GO:0001667	ameboidal-type cell migration	203	344	6.95e-10
GO:BP	GO:0050804	modulation of chemical synaptic transmission	192	322	7.08e-10
GO:BP	GO:1901888	regulation of cell junction assembly	106	156	7.21e-10
GO:BP	GO:0016043	cellular component organization	2151	4802	7.49e-10
GO:BP	GO:0099537	trans-synaptic signaling	263	467	7.71e-10
GO:BP	GO:0006810	transport	1383	2984	7.86e-10
GO:BP	GO:0010648	negative regulation of cell communication	527	1034	9.38e-10
GO:BP	GO:0050808	synapse organization	199	337	9.77e-10
GO:BP	GO:0099177	regulation of trans-synaptic signaling	192	323	9.90e-10
GO:BP	GO:0098660	inorganic ion transmembrane transport	288	521	1.34e-09
GO:BP	GO:0006897	endocytosis	274	492	1.43e-09
GO:BP	GO:0007268	chemical synaptic transmission	260	463	1.45e-09
GO:BP	GO:0098916	anterograde trans-synaptic signaling	260	463	1.45e-09
GO:BP	GO:0006468	protein phosphorylation	491	958	1.65e-09
GO:BP	GO:0060560	developmental growth involved in morphogenesis	123	190	2.31e-09
GO:BP	GO:0097435	supramolecular fiber organization	340	633	2.31e-09
GO:BP	GO:0032879	regulation of localization	706	1439	2.98e-09
GO:BP	GO:0007423	sensory organ development	222	387	2.98e-09
GO:BP	GO:0007507	heart development	276	499	3.11e-09
GO:BP	GO:0048041	focal adhesion assembly	60	77	3.36e-09
GO:BP	GO:0007411	axon guidance	113	172	3.57e-09
GO:BP	GO:0097485	neuron projection guidance	113	172	3.57e-09
GO:BP	GO:0048568	embryonic organ development	180	303	4.25e-09
GO:BP	GO:0010720	positive regulation of cell development	183	309	4.25e-09
GO:BP	GO:0140352	export from cell	320	594	5.44e-09
GO:BP	GO:1902531	regulation of intracellular signal transduction	637	1289	6.34e-09
GO:BP	GO:2000147	positive regulation of cell motility	231	408	6.36e-09
GO:BP	GO:0010959	regulation of metal ion transport	147	239	7.52e-09
GO:BP	GO:0034220	monoatomic ion transmembrane transport	316	587	7.84e-09
GO:BP	GO:0060562	epithelial tube morphogenesis	158	261	8.50e-09
GO:BP	GO:0048585	negative regulation of response to stimulus	593	1193	9.14e-09
GO:BP	GO:0030335	positive regulation of cell migration	224	395	9.76e-09
GO:BP	GO:0006811	monoatomic ion transport	377	719	1.04e-08
GO:BP	GO:0040017	positive regulation of locomotion	234	416	1.07e-08
GO:BP	GO:0016310	phosphorylation	571	1145	1.07e-08
GO:BP	GO:0008283	cell population proliferation	643	1306	1.09e-08
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	151	248	1.15e-08
GO:BP	GO:0051130	positive regulation of cellular component organization	437	850	1.17e-08
GO:BP	GO:0050767	regulation of neurogenesis	172	290	1.24e-08
GO:BP	GO:0014706	striated muscle tissue development	133	213	1.26e-08
GO:BP	GO:0060284	regulation of cell development	307	570	1.26e-08
GO:BP	GO:0007015	actin filament organization	205	357	1.28e-08
GO:BP	GO:0099003	vesicle-mediated transport in synapse	110	169	1.32e-08
GO:BP	GO:0051179	localization	1689	3731	1.39e-08
GO:BP	GO:1903522	regulation of blood circulation	123	194	1.44e-08
GO:BP	GO:0009968	negative regulation of signal transduction	492	972	1.44e-08
GO:BP	GO:0098655	monoatomic cation transmembrane transport	271	495	1.66e-08
GO:BP	GO:0007417	central nervous system development	364	694	1.93e-08
GO:BP	GO:0009605	response to external stimulus	753	1559	2.23e-08
GO:BP	GO:0060322	head development	291	539	2.61e-08
GO:BP	GO:0098662	inorganic cation transmembrane transport	263	480	2.70e-08
GO:BP	GO:0055085	transmembrane transport	467	921	3.09e-08
GO:BP	GO:0060047	heart contraction	122	194	3.48e-08
GO:BP	GO:0050877	nervous system process	319	600	3.57e-08
GO:BP	GO:0042127	regulation of cell population proliferation	537	1077	3.74e-08
GO:BP	GO:0009967	positive regulation of signal transduction	544	1093	4.02e-08
GO:BP	GO:0046903	secretion	329	622	4.02e-08
GO:BP	GO:0048588	developmental cell growth	114	179	4.13e-08
GO:BP	GO:0043269	regulation of monoatomic ion transport	166	282	5.13e-08
GO:BP	GO:0007420	brain development	270	498	6.22e-08
GO:BP	GO:0006812	monoatomic cation transport	324	614	7.54e-08
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	118	188	7.54e-08
GO:BP	GO:0097553	calcium ion transmembrane import into cytosol	83	122	8.32e-08
GO:BP	GO:0007160	cell-matrix adhesion	108	169	8.44e-08
GO:BP	GO:0003015	heart process	126	204	8.99e-08
GO:BP	GO:0009611	response to wounding	214	382	8.99e-08
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	129	210	9.44e-08
GO:BP	GO:0060537	muscle tissue development	193	339	9.98e-08
GO:BP	GO:0031346	positive regulation of cell projection organization	167	286	1.01e-07
GO:BP	GO:0042391	regulation of membrane potential	165	282	1.01e-07
GO:BP	GO:0045229	external encapsulating structure organization	136	224	1.01e-07
GO:BP	GO:0043062	extracellular structure organization	136	224	1.01e-07
GO:BP	GO:0051093	negative regulation of developmental process	327	622	1.02e-07
GO:BP	GO:0042692	muscle cell differentiation	185	323	1.11e-07
GO:BP	GO:0048738	cardiac muscle tissue development	124	201	1.29e-07
GO:BP	GO:0030198	extracellular matrix organization	135	223	1.48e-07
GO:BP	GO:0051234	establishment of localization	1471	3240	1.50e-07
GO:BP	GO:0007610	behavior	231	420	1.78e-07
GO:BP	GO:0070887	cellular response to chemical stimulus	830	1751	2.03e-07
GO:BP	GO:0030900	forebrain development	159	272	2.10e-07
GO:BP	GO:0003007	heart morphogenesis	132	218	2.13e-07
GO:BP	GO:0090109	regulation of cell-substrate junction assembly	44	55	2.17e-07
GO:BP	GO:0051893	regulation of focal adhesion assembly	44	55	2.17e-07
GO:BP	GO:0150116	regulation of cell-substrate junction organization	47	60	2.28e-07
GO:BP	GO:0044089	positive regulation of cellular component biogenesis	216	390	2.56e-07
GO:BP	GO:0009792	embryo development ending in birth or egg hatching	278	521	2.56e-07
GO:BP	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	77	113	2.60e-07
GO:BP	GO:0048638	regulation of developmental growth	144	243	3.18e-07
GO:BP	GO:0040007	growth	359	697	3.30e-07
GO:BP	GO:0001952	regulation of cell-matrix adhesion	64	90	3.70e-07
GO:BP	GO:0003018	vascular process in circulatory system	119	194	4.07e-07
GO:BP	GO:0098771	inorganic ion homeostasis	195	348	4.15e-07
GO:BP	GO:0023061	signal release	179	315	4.18e-07
GO:BP	GO:0032940	secretion by cell	291	551	4.18e-07
GO:BP	GO:0008016	regulation of heart contraction	104	165	4.41e-07
GO:BP	GO:0001775	cell activation	326	627	4.63e-07
GO:BP	GO:0045785	positive regulation of cell adhesion	172	301	4.66e-07
GO:BP	GO:0090257	regulation of muscle system process	110	177	5.15e-07
GO:BP	GO:0043009	chordate embryonic development	270	507	5.17e-07
GO:BP	GO:0044093	positive regulation of molecular function	397	783	5.55e-07
GO:BP	GO:0030048	actin filament-based movement	73	107	5.64e-07
GO:BP	GO:0001837	epithelial to mesenchymal transition	89	137	6.08e-07
GO:BP	GO:0065009	regulation of molecular function	627	1299	7.82e-07
GO:BP	GO:0003205	cardiac chamber development	96	151	8.38e-07
GO:BP	GO:0051924	regulation of calcium ion transport	97	153	8.67e-07
GO:BP	GO:0051146	striated muscle cell differentiation	138	234	9.29e-07
GO:BP	GO:0051962	positive regulation of nervous system development	127	212	9.33e-07
GO:BP	GO:0003206	cardiac chamber morphogenesis	74	110	1.11e-06
GO:BP	GO:0090596	sensory organ morphogenesis	107	173	1.13e-06
GO:BP	GO:0050770	regulation of axonogenesis	82	125	1.13e-06
GO:BP	GO:0001823	mesonephros development	54	74	1.19e-06
GO:BP	GO:0006915	apoptotic process	660	1377	1.19e-06
GO:BP	GO:0048584	positive regulation of response to stimulus	715	1504	1.51e-06
GO:BP	GO:0071310	cellular response to organic substance	624	1297	1.51e-06
GO:BP	GO:0010033	response to organic substance	816	1736	1.62e-06
GO:BP	GO:0006935	chemotaxis	142	244	1.78e-06
GO:BP	GO:0042330	taxis	142	244	1.78e-06
GO:BP	GO:0042060	wound healing	165	291	1.78e-06
GO:BP	GO:0001501	skeletal system development	192	347	1.78e-06
GO:BP	GO:0071417	cellular response to organonitrogen compound	237	442	1.80e-06
GO:BP	GO:0099504	synaptic vesicle cycle	95	151	1.98e-06
GO:BP	GO:0072164	mesonephric tubule development	53	73	2.05e-06
GO:BP	GO:0072163	mesonephric epithelium development	53	73	2.05e-06
GO:BP	GO:0001654	eye development	151	263	2.20e-06
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	161	284	2.57e-06
GO:BP	GO:0016358	dendrite development	111	183	2.65e-06
GO:BP	GO:1903169	regulation of calcium ion transmembrane transport	72	108	2.81e-06
GO:BP	GO:0048880	sensory system development	152	266	2.98e-06
GO:BP	GO:0150063	visual system development	151	264	3.02e-06
GO:BP	GO:0035265	organ growth	82	127	3.04e-06
GO:BP	GO:0033002	muscle cell proliferation	95	152	3.04e-06
GO:BP	GO:0090066	regulation of anatomical structure size	206	379	3.48e-06
GO:BP	GO:0001657	ureteric bud development	52	72	3.52e-06
GO:BP	GO:0050803	regulation of synapse structure or activity	107	176	3.75e-06
GO:BP	GO:0071840	cellular component organization or biogenesis	2188	4988	3.78e-06
GO:BP	GO:0071773	cellular response to BMP stimulus	77	118	3.81e-06
GO:BP	GO:0071772	response to BMP	77	118	3.81e-06
GO:BP	GO:0031032	actomyosin structure organization	111	184	3.82e-06
GO:BP	GO:0008219	cell death	676	1423	4.02e-06
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	1105	2415	4.06e-06
GO:BP	GO:0001763	morphogenesis of a branching structure	91	145	4.15e-06
GO:BP	GO:0031345	negative regulation of cell projection organization	91	145	4.15e-06
GO:BP	GO:0043410	positive regulation of MAPK cascade	162	288	4.43e-06
GO:BP	GO:0006937	regulation of muscle contraction	81	126	4.59e-06
GO:BP	GO:0010717	regulation of epithelial to mesenchymal transition	59	85	4.65e-06
GO:BP	GO:0040013	negative regulation of locomotion	140	243	4.67e-06
GO:BP	GO:0050807	regulation of synapse organization	105	173	5.31e-06
GO:BP	GO:1990138	neuron projection extension	85	134	5.36e-06
GO:BP	GO:0061448	connective tissue development	121	205	5.48e-06
GO:BP	GO:0009893	positive regulation of metabolic process	1192	2622	5.52e-06
GO:BP	GO:0012501	programmed cell death	673	1419	5.62e-06
GO:BP	GO:0048639	positive regulation of developmental growth	77	119	6.13e-06
GO:BP	GO:0006941	striated muscle contraction	91	146	6.34e-06
GO:BP	GO:0051050	positive regulation of transport	294	571	6.66e-06
GO:BP	GO:0014070	response to organic cyclic compound	310	606	6.78e-06
GO:BP	GO:0010243	response to organonitrogen compound	346	685	6.80e-06
GO:BP	GO:0032970	regulation of actin filament-based process	167	300	6.91e-06
GO:BP	GO:0055074	calcium ion homeostasis	126	216	7.43e-06
GO:BP	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	53	75	7.75e-06
GO:BP	GO:0006874	intracellular calcium ion homeostasis	119	202	7.75e-06
GO:BP	GO:0050769	positive regulation of neurogenesis	110	184	7.79e-06
GO:BP	GO:0010632	regulation of epithelial cell migration	112	188	7.79e-06
GO:BP	GO:0061138	morphogenesis of a branching epithelium	85	135	8.23e-06
GO:BP	GO:0090130	tissue migration	141	247	8.45e-06
GO:BP	GO:0022898	regulation of transmembrane transporter activity	87	139	8.65e-06
GO:BP	GO:0048167	regulation of synaptic plasticity	87	139	8.65e-06
GO:BP	GO:0099173	postsynapse organization	91	147	9.51e-06
GO:BP	GO:0045165	cell fate commitment	93	151	9.85e-06
GO:BP	GO:0051283	negative regulation of sequestering of calcium ion	61	90	1.00e-05
GO:BP	GO:0055001	muscle cell development	99	163	1.06e-05
GO:BP	GO:1905314	semi-lunar valve development	33	41	1.10e-05
GO:BP	GO:0022604	regulation of cell morphogenesis	114	193	1.10e-05
GO:BP	GO:0072001	renal system development	139	244	1.18e-05
GO:BP	GO:0061572	actin filament bundle organization	83	132	1.20e-05
GO:BP	GO:0072073	kidney epithelium development	72	111	1.24e-05
GO:BP	GO:1901699	cellular response to nitrogen compound	250	479	1.29e-05
GO:BP	GO:0003231	cardiac ventricle development	74	115	1.36e-05
GO:BP	GO:0032409	regulation of transporter activity	91	148	1.43e-05
GO:BP	GO:0060395	SMAD protein signal transduction	53	76	1.45e-05
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	122	210	1.45e-05
GO:BP	GO:1901698	response to nitrogen compound	367	736	1.45e-05
GO:BP	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	93	152	1.45e-05
GO:BP	GO:0070252	actin-mediated cell contraction	59	87	1.45e-05
GO:BP	GO:0042472	inner ear morphogenesis	44	60	1.45e-05
GO:BP	GO:0030855	epithelial cell differentiation	226	428	1.46e-05
GO:BP	GO:0010631	epithelial cell migration	138	243	1.58e-05
GO:BP	GO:0090132	epithelium migration	138	243	1.58e-05
GO:BP	GO:0051209	release of sequestered calcium ion into cytosol	60	89	1.58e-05
GO:BP	GO:0045321	leukocyte activation	273	530	1.58e-05
GO:BP	GO:0003179	heart valve morphogenesis	41	55	1.70e-05
GO:BP	GO:0051336	regulation of hydrolase activity	227	431	1.75e-05
GO:BP	GO:0051017	actin filament bundle assembly	82	131	1.75e-05
GO:BP	GO:0050878	regulation of body fluid levels	131	229	1.75e-05
GO:BP	GO:0060419	heart growth	50	71	1.83e-05
GO:BP	GO:0030509	BMP signaling pathway	71	110	1.86e-05
GO:BP	GO:0048010	vascular endothelial growth factor receptor signaling pathway	38	50	1.91e-05
GO:BP	GO:0051216	cartilage development	89	145	2.01e-05
GO:BP	GO:0060048	cardiac muscle contraction	74	116	2.12e-05
GO:BP	GO:0007163	establishment or maintenance of cell polarity	108	183	2.19e-05
GO:BP	GO:0090288	negative regulation of cellular response to growth factor stimulus	52	75	2.33e-05
GO:BP	GO:0043010	camera-type eye development	131	230	2.38e-05
GO:BP	GO:0051046	regulation of secretion	210	396	2.38e-05
GO:BP	GO:0002062	chondrocyte differentiation	59	88	2.50e-05
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	241	463	2.53e-05
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	241	463	2.53e-05
GO:BP	GO:0031325	positive regulation of cellular metabolic process	1061	2333	2.77e-05
GO:BP	GO:0051129	negative regulation of cellular component organization	283	555	2.87e-05
GO:BP	GO:0009987	cellular process	4477	10686	2.87e-05
GO:BP	GO:0051282	regulation of sequestering of calcium ion	61	92	2.87e-05
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	355	714	2.98e-05
GO:BP	GO:0045216	cell-cell junction organization	92	152	3.05e-05
GO:BP	GO:0042592	homeostatic process	543	1137	3.10e-05
GO:BP	GO:0048878	chemical homeostasis	335	670	3.13e-05
GO:BP	GO:0072006	nephron development	73	115	3.18e-05
GO:BP	GO:0060976	coronary vasculature development	34	44	3.70e-05
GO:BP	GO:1901700	response to oxygen-containing compound	523	1093	3.73e-05
GO:BP	GO:0003279	cardiac septum development	66	102	3.83e-05
GO:BP	GO:0021915	neural tube development	82	133	4.02e-05
GO:BP	GO:1901890	positive regulation of cell junction assembly	52	76	4.19e-05
GO:BP	GO:0048844	artery morphogenesis	42	58	4.23e-05
GO:BP	GO:0002521	leukocyte differentiation	197	371	4.38e-05
GO:BP	GO:0003151	outflow tract morphogenesis	47	67	4.38e-05
GO:BP	GO:0060411	cardiac septum morphogenesis	47	67	4.38e-05
GO:BP	GO:2000181	negative regulation of blood vessel morphogenesis	47	67	4.38e-05
GO:BP	GO:0015833	peptide transport	105	179	4.38e-05
GO:BP	GO:1901343	negative regulation of vasculature development	47	67	4.38e-05
GO:BP	GO:0030510	regulation of BMP signaling pathway	53	78	4.52e-05
GO:BP	GO:0060078	regulation of postsynaptic membrane potential	53	78	4.52e-05
GO:BP	GO:0001822	kidney development	133	237	5.47e-05
GO:BP	GO:1901342	regulation of vasculature development	114	198	5.56e-05
GO:BP	GO:0030100	regulation of endocytosis	113	196	5.62e-05
GO:BP	GO:0045765	regulation of angiogenesis	112	194	5.67e-05
GO:BP	GO:0045596	negative regulation of cell differentiation	234	452	5.77e-05
GO:BP	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	82	134	5.93e-05
GO:BP	GO:0051058	negative regulation of small GTPase mediated signal transduction	36	48	5.93e-05
GO:BP	GO:0055008	cardiac muscle tissue morphogenesis	40	55	6.05e-05
GO:BP	GO:0018212	peptidyl-tyrosine modification	97	164	6.31e-05
GO:BP	GO:0009612	response to mechanical stimulus	91	152	6.31e-05
GO:BP	GO:0048644	muscle organ morphogenesis	45	64	6.39e-05
GO:BP	GO:0055017	cardiac muscle tissue growth	45	64	6.39e-05
GO:BP	GO:0060038	cardiac muscle cell proliferation	33	43	6.54e-05
GO:BP	GO:0048168	regulation of neuronal synaptic plasticity	30	38	6.72e-05
GO:BP	GO:0009628	response to abiotic stimulus	396	811	6.72e-05
GO:BP	GO:0006949	syncytium formation	30	38	6.72e-05
GO:BP	GO:0043408	regulation of MAPK cascade	222	427	6.89e-05
GO:BP	GO:0007389	pattern specification process	156	286	6.89e-05
GO:BP	GO:0048813	dendrite morphogenesis	70	111	6.89e-05
GO:BP	GO:0048771	tissue remodeling	71	113	7.06e-05
GO:BP	GO:0016525	negative regulation of angiogenesis	46	66	7.11e-05
GO:BP	GO:0061035	regulation of cartilage development	37	50	7.12e-05
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	144	261	7.16e-05
GO:BP	GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	143	259	7.33e-05
GO:BP	GO:0050801	monoatomic ion homeostasis	212	406	7.75e-05
GO:BP	GO:0007611	learning or memory	109	189	7.84e-05
GO:BP	GO:2000027	regulation of animal organ morphogenesis	42	59	8.04e-05
GO:BP	GO:0010634	positive regulation of epithelial cell migration	78	127	8.12e-05
GO:BP	GO:0006813	potassium ion transport	82	135	8.51e-05
GO:BP	GO:0006836	neurotransmitter transport	82	135	8.51e-05
GO:BP	GO:0046632	alpha-beta T cell differentiation	48	70	8.73e-05
GO:BP	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	121	214	8.82e-05
GO:BP	GO:0060415	muscle tissue morphogenesis	43	61	9.17e-05
GO:BP	GO:0060840	artery development	56	85	9.45e-05
GO:BP	GO:0050806	positive regulation of synaptic transmission	67	106	9.62e-05
GO:BP	GO:0046879	hormone secretion	115	202	9.75e-05
GO:BP	GO:0006796	phosphate-containing compound metabolic process	862	1883	1.02e-04
GO:BP	GO:0055080	monoatomic cation homeostasis	209	401	1.04e-04
GO:BP	GO:0031644	regulation of nervous system process	50	74	1.04e-04
GO:BP	GO:0045927	positive regulation of growth	106	184	1.11e-04
GO:BP	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	59	91	1.11e-04
GO:BP	GO:0048562	embryonic organ morphogenesis	105	182	1.12e-04
GO:BP	GO:0006898	receptor-mediated endocytosis	105	182	1.12e-04
GO:BP	GO:0071805	potassium ion transmembrane transport	74	120	1.13e-04
GO:BP	GO:0007517	muscle organ development	146	267	1.13e-04
GO:BP	GO:2000146	negative regulation of cell motility	122	217	1.14e-04
GO:BP	GO:0003170	heart valve development	45	65	1.14e-04
GO:BP	GO:0022612	gland morphogenesis	60	93	1.15e-04
GO:BP	GO:0003176	aortic valve development	29	37	1.19e-04
GO:BP	GO:0002790	peptide secretion	97	166	1.19e-04
GO:BP	GO:0035725	sodium ion transmembrane transport	61	95	1.19e-04
GO:BP	GO:0010811	positive regulation of cell-substrate adhesion	61	95	1.19e-04
GO:BP	GO:0018108	peptidyl-tyrosine phosphorylation	95	162	1.20e-04
GO:BP	GO:0043085	positive regulation of catalytic activity	275	546	1.21e-04
GO:BP	GO:0006793	phosphorus metabolic process	870	1904	1.23e-04
GO:BP	GO:0009914	hormone transport	117	207	1.23e-04
GO:BP	GO:0072028	nephron morphogenesis	41	58	1.31e-04
GO:BP	GO:0051235	maintenance of location	138	251	1.36e-04
GO:BP	GO:0001934	positive regulation of protein phosphorylation	206	396	1.37e-04
GO:BP	GO:0006939	smooth muscle contraction	47	69	1.37e-04
GO:BP	GO:0003281	ventricular septum development	47	69	1.37e-04
GO:BP	GO:0001932	regulation of protein phosphorylation	318	642	1.38e-04
GO:BP	GO:0072132	mesenchyme morphogenesis	37	51	1.41e-04
GO:BP	GO:0048754	branching morphogenesis of an epithelial tube	70	113	1.55e-04
GO:BP	GO:0030336	negative regulation of cell migration	118	210	1.62e-04
GO:BP	GO:0003208	cardiac ventricle morphogenesis	43	62	1.66e-04
GO:BP	GO:0009891	positive regulation of biosynthetic process	848	1856	1.66e-04
GO:BP	GO:0019722	calcium-mediated signaling	75	123	1.67e-04
GO:BP	GO:0010628	positive regulation of gene expression	364	746	1.68e-04
GO:BP	GO:0043270	positive regulation of monoatomic ion transport	77	127	1.69e-04
GO:BP	GO:0016049	cell growth	199	382	1.71e-04
GO:BP	GO:0006814	sodium ion transport	82	137	1.73e-04
GO:BP	GO:0016192	vesicle-mediated transport	543	1152	1.75e-04
GO:BP	GO:0051208	sequestering of calcium ion	61	96	1.87e-04
GO:BP	GO:0060627	regulation of vesicle-mediated transport	195	374	1.95e-04
GO:BP	GO:0198738	cell-cell signaling by wnt	188	359	1.98e-04
GO:BP	GO:0050919	negative chemotaxis	31	41	1.98e-04
GO:BP	GO:0140253	cell-cell fusion	28	36	2.15e-04
GO:BP	GO:0000768	syncytium formation by plasma membrane fusion	28	36	2.15e-04
GO:BP	GO:0060993	kidney morphogenesis	46	68	2.20e-04
GO:BP	GO:0043087	regulation of GTPase activity	96	166	2.28e-04
GO:BP	GO:1902414	protein localization to cell junction	55	85	2.33e-04
GO:BP	GO:0061337	cardiac conduction	55	85	2.33e-04
GO:BP	GO:0098659	inorganic cation import across plasma membrane	47	70	2.37e-04
GO:BP	GO:0099587	inorganic ion import across plasma membrane	47	70	2.37e-04
GO:BP	GO:0099565	chemical synaptic transmission, postsynaptic	47	70	2.37e-04
GO:BP	GO:0031399	regulation of protein modification process	436	911	2.38e-04
GO:BP	GO:0016331	morphogenesis of embryonic epithelium	74	122	2.40e-04
GO:BP	GO:0051279	regulation of release of sequestered calcium ion into cytosol	41	59	2.41e-04
GO:BP	GO:0007613	memory	56	87	2.41e-04
GO:BP	GO:0071526	semaphorin-plexin signaling pathway	32	43	2.42e-04
GO:BP	GO:0060348	bone development	86	146	2.42e-04
GO:BP	GO:0007369	gastrulation	83	140	2.44e-04
GO:BP	GO:0021537	telencephalon development	110	195	2.44e-04
GO:BP	GO:0016055	Wnt signaling pathway	187	358	2.47e-04
GO:BP	GO:0048863	stem cell differentiation	108	191	2.53e-04
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	839	1841	2.80e-04
GO:BP	GO:0048660	regulation of smooth muscle cell proliferation	61	97	2.87e-04
GO:BP	GO:0003180	aortic valve morphogenesis	26	33	2.90e-04
GO:BP	GO:0060675	ureteric bud morphogenesis	33	45	2.91e-04
GO:BP	GO:0042886	amide transport	114	204	3.01e-04
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	986	2186	3.07e-04
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	817	1791	3.13e-04
GO:BP	GO:0051247	positive regulation of protein metabolic process	435	911	3.13e-04
GO:BP	GO:0035023	regulation of Rho protein signal transduction	44	65	3.19e-04
GO:BP	GO:0010977	negative regulation of neuron projection development	67	109	3.24e-04
GO:BP	GO:1901701	cellular response to oxygen-containing compound	384	796	3.28e-04
GO:BP	GO:0031401	positive regulation of protein modification process	274	550	3.29e-04
GO:BP	GO:1903530	regulation of secretion by cell	190	366	3.34e-04
GO:BP	GO:0071407	cellular response to organic cyclic compound	196	379	3.34e-04
GO:BP	GO:2001257	regulation of cation channel activity	45	67	3.44e-04
GO:BP	GO:0072088	nephron epithelium morphogenesis	39	56	3.49e-04
GO:BP	GO:0000165	MAPK cascade	253	504	3.50e-04
GO:BP	GO:0050890	cognition	118	213	3.58e-04
GO:BP	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	55	86	3.63e-04
GO:BP	GO:0002376	immune system process	652	1410	3.74e-04
GO:BP	GO:0046631	alpha-beta T cell activation	56	88	3.76e-04
GO:BP	GO:0050673	epithelial cell proliferation	159	300	3.86e-04
GO:BP	GO:0008150	biological_process	4682	11244	3.90e-04
GO:BP	GO:0003177	pulmonary valve development	19	22	3.91e-04
GO:BP	GO:0060390	regulation of SMAD protein signal transduction	35	49	3.94e-04
GO:BP	GO:0042327	positive regulation of phosphorylation	212	415	4.15e-04
GO:BP	GO:0003184	pulmonary valve morphogenesis	17	19	4.23e-04
GO:BP	GO:0030072	peptide hormone secretion	93	162	4.29e-04
GO:BP	GO:0051174	regulation of phosphorus metabolic process	387	805	4.34e-04
GO:BP	GO:0007159	leukocyte cell-cell adhesion	120	218	4.42e-04
GO:BP	GO:0099643	signal release from synapse	63	102	4.47e-04
GO:BP	GO:0007269	neurotransmitter secretion	63	102	4.47e-04
GO:BP	GO:0071692	protein localization to extracellular region	138	256	4.50e-04
GO:BP	GO:0002573	myeloid leukocyte differentiation	88	152	4.53e-04
GO:BP	GO:0014033	neural crest cell differentiation	50	77	4.63e-04
GO:BP	GO:0035108	limb morphogenesis	67	110	4.70e-04
GO:BP	GO:0035107	appendage morphogenesis	67	110	4.70e-04
GO:BP	GO:0060173	limb development	80	136	4.80e-04
GO:BP	GO:0007416	synapse assembly	80	136	4.80e-04
GO:BP	GO:0048736	appendage development	80	136	4.80e-04
GO:BP	GO:0098739	import across plasma membrane	73	122	4.85e-04
GO:BP	GO:0035148	tube formation	74	124	4.85e-04
GO:BP	GO:0055010	ventricular cardiac muscle tissue morphogenesis	32	44	4.85e-04
GO:BP	GO:0007215	glutamate receptor signaling pathway	22	27	4.95e-04
GO:BP	GO:1904064	positive regulation of cation transmembrane transport	52	81	4.99e-04
GO:BP	GO:0099175	regulation of postsynapse organization	52	81	4.99e-04
GO:BP	GO:0019220	regulation of phosphate metabolic process	386	804	4.99e-04
GO:BP	GO:0006954	inflammatory response	216	425	5.09e-04
GO:BP	GO:0002027	regulation of heart rate	53	83	5.18e-04
GO:BP	GO:0014902	myotube differentiation	54	85	5.38e-04
GO:BP	GO:0042325	regulation of phosphorylation	332	683	5.46e-04
GO:BP	GO:0032101	regulation of response to external stimulus	319	654	5.59e-04
GO:BP	GO:0097120	receptor localization to synapse	33	46	5.63e-04
GO:BP	GO:0072171	mesonephric tubule morphogenesis	33	46	5.63e-04
GO:BP	GO:0042981	regulation of apoptotic process	485	1031	6.21e-04
GO:BP	GO:0043583	ear development	87	151	6.21e-04
GO:BP	GO:0051345	positive regulation of hydrolase activity	142	266	6.27e-04
GO:BP	GO:0003272	endocardial cushion formation	20	24	6.27e-04
GO:BP	GO:0001755	neural crest cell migration	34	48	6.48e-04
GO:BP	GO:0010718	positive regulation of epithelial to mesenchymal transition	34	48	6.48e-04
GO:BP	GO:0046649	lymphocyte activation	224	444	6.54e-04
GO:BP	GO:0140238	presynaptic endocytosis	40	59	6.65e-04
GO:BP	GO:0050920	regulation of chemotaxis	78	133	6.65e-04
GO:BP	GO:0042471	ear morphogenesis	48	74	6.65e-04
GO:BP	GO:0051961	negative regulation of nervous system development	66	109	6.65e-04
GO:BP	GO:0048864	stem cell development	48	74	6.65e-04
GO:BP	GO:0010927	cellular component assembly involved in morphogenesis	65	107	6.65e-04
GO:BP	GO:0007266	Rho protein signal transduction	66	109	6.65e-04
GO:BP	GO:0048839	inner ear development	78	133	6.65e-04
GO:BP	GO:0014888	striated muscle adaptation	30	41	6.87e-04
GO:BP	GO:0040008	regulation of growth	232	462	6.87e-04
GO:BP	GO:0061383	trabecula morphogenesis	30	41	6.87e-04
GO:BP	GO:0098815	modulation of excitatory postsynaptic potential	30	41	6.87e-04
GO:BP	GO:0003002	regionalization	138	258	6.91e-04
GO:BP	GO:0050790	regulation of catalytic activity	424	893	6.91e-04
GO:BP	GO:0043067	regulation of programmed cell death	497	1060	7.18e-04
GO:BP	GO:0090497	mesenchymal cell migration	35	50	7.18e-04
GO:BP	GO:0009991	response to extracellular stimulus	193	377	7.52e-04
GO:BP	GO:0071375	cellular response to peptide hormone stimulus	125	231	7.94e-04
GO:BP	GO:0007498	mesoderm development	53	84	7.97e-04
GO:BP	GO:0048645	animal organ formation	36	52	8.05e-04
GO:BP	GO:0060079	excitatory postsynaptic potential	43	65	8.21e-04
GO:BP	GO:0022407	regulation of cell-cell adhesion	147	278	8.25e-04
GO:BP	GO:0060070	canonical Wnt signaling pathway	130	242	8.75e-04
GO:BP	GO:0072078	nephron tubule morphogenesis	37	54	8.91e-04
GO:BP	GO:0001704	formation of primary germ layer	58	94	8.93e-04
GO:BP	GO:0070372	regulation of ERK1 and ERK2 cascade	98	175	9.11e-04
GO:BP	GO:0110110	positive regulation of animal organ morphogenesis	21	26	9.11e-04
GO:BP	GO:0060043	regulation of cardiac muscle cell proliferation	24	31	9.11e-04
GO:BP	GO:0014032	neural crest cell development	45	69	9.18e-04
GO:BP	GO:0003158	endothelium development	61	100	9.25e-04
GO:BP	GO:0055082	intracellular chemical homeostasis	242	486	9.29e-04
GO:BP	GO:0034764	positive regulation of transmembrane transport	76	130	9.29e-04
GO:BP	GO:0030010	establishment of cell polarity	73	124	9.41e-04
GO:BP	GO:0008360	regulation of cell shape	64	106	9.41e-04
GO:BP	GO:0001838	embryonic epithelial tube formation	64	106	9.41e-04
GO:BP	GO:0031214	biomineral tissue development	64	106	9.41e-04
GO:BP	GO:0007612	learning	66	110	9.48e-04
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	217	431	9.52e-04
GO:BP	GO:0003229	ventricular cardiac muscle tissue development	38	56	9.57e-04
GO:BP	GO:0003300	cardiac muscle hypertrophy	47	73	9.98e-04
GO:BP	GO:0018105	peptidyl-serine phosphorylation	91	161	1.03e-03
GO:BP	GO:0061333	renal tubule morphogenesis	39	58	1.04e-03
GO:BP	GO:0048488	synaptic vesicle endocytosis	39	58	1.04e-03
GO:BP	GO:0014896	muscle hypertrophy	48	75	1.04e-03
GO:BP	GO:0008544	epidermis development	114	209	1.04e-03
GO:BP	GO:0002761	regulation of myeloid leukocyte differentiation	50	79	1.11e-03
GO:BP	GO:1902893	regulation of miRNA transcription	40	60	1.12e-03
GO:BP	GO:0006942	regulation of striated muscle contraction	51	81	1.15e-03
GO:BP	GO:0060412	ventricular septum morphogenesis	29	40	1.16e-03
GO:BP	GO:0050708	regulation of protein secretion	99	178	1.16e-03
GO:BP	GO:0061036	positive regulation of cartilage development	19	23	1.16e-03
GO:BP	GO:0006873	intracellular monoatomic ion homeostasis	184	360	1.20e-03
GO:BP	GO:0009306	protein secretion	134	252	1.20e-03
GO:BP	GO:0035592	establishment of protein localization to extracellular region	134	252	1.20e-03
GO:BP	GO:0030097	hemopoiesis	303	624	1.22e-03
GO:BP	GO:0034446	substrate adhesion-dependent cell spreading	54	87	1.22e-03
GO:BP	GO:0030073	insulin secretion	79	137	1.22e-03
GO:BP	GO:0060421	positive regulation of heart growth	22	28	1.22e-03
GO:BP	GO:2000463	positive regulation of excitatory postsynaptic potential	22	28	1.22e-03
GO:BP	GO:0030947	regulation of vascular endothelial growth factor receptor signaling pathway	22	28	1.22e-03
GO:BP	GO:0048732	gland development	160	308	1.22e-03
GO:BP	GO:0050900	leukocyte migration	107	195	1.23e-03
GO:BP	GO:0086003	cardiac muscle cell contraction	42	64	1.25e-03
GO:BP	GO:0034767	positive regulation of monoatomic ion transmembrane transport	56	91	1.25e-03
GO:BP	GO:0019935	cyclic-nucleotide-mediated signaling	35	51	1.26e-03
GO:BP	GO:0050771	negative regulation of axonogenesis	35	51	1.26e-03
GO:BP	GO:1903131	mononuclear cell differentiation	146	278	1.26e-03
GO:BP	GO:0010976	positive regulation of neuron projection development	75	129	1.26e-03
GO:BP	GO:0001707	mesoderm formation	35	51	1.26e-03
GO:BP	GO:0048675	axon extension	58	95	1.27e-03
GO:BP	GO:0031667	response to nutrient levels	181	354	1.30e-03
GO:BP	GO:0035296	regulation of tube diameter	61	101	1.30e-03
GO:BP	GO:0097746	blood vessel diameter maintenance	61	101	1.30e-03
GO:BP	GO:0035150	regulation of tube size	61	101	1.30e-03
GO:BP	GO:0048659	smooth muscle cell proliferation	61	101	1.30e-03
GO:BP	GO:1902107	positive regulation of leukocyte differentiation	68	115	1.30e-03
GO:BP	GO:0050768	negative regulation of neurogenesis	62	103	1.30e-03
GO:BP	GO:1903708	positive regulation of hemopoiesis	68	115	1.30e-03
GO:BP	GO:0032535	regulation of cellular component size	150	287	1.35e-03
GO:BP	GO:0055002	striated muscle cell development	44	68	1.35e-03
GO:BP	GO:0048332	mesoderm morphogenesis	36	53	1.36e-03
GO:BP	GO:0007162	negative regulation of cell adhesion	102	185	1.36e-03
GO:BP	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	100	181	1.43e-03
GO:BP	GO:0030031	cell projection assembly	223	447	1.45e-03
GO:BP	GO:0071559	response to transforming growth factor beta	118	219	1.47e-03
GO:BP	GO:0002064	epithelial cell development	84	148	1.51e-03
GO:BP	GO:0014897	striated muscle hypertrophy	47	74	1.52e-03
GO:BP	GO:0061326	renal tubule development	47	74	1.52e-03
GO:BP	GO:0030003	intracellular monoatomic cation homeostasis	181	355	1.54e-03
GO:BP	GO:0010817	regulation of hormone levels	164	318	1.54e-03
GO:BP	GO:0031099	regeneration	82	144	1.55e-03
GO:BP	GO:0030513	positive regulation of BMP signaling pathway	23	30	1.55e-03
GO:BP	GO:0060996	dendritic spine development	48	76	1.56e-03
GO:BP	GO:0046777	protein autophosphorylation	81	142	1.57e-03
GO:BP	GO:0070371	ERK1 and ERK2 cascade	106	194	1.58e-03
GO:BP	GO:0043217	myelin maintenance	13	14	1.59e-03
GO:BP	GO:0010954	positive regulation of protein processing	15	17	1.59e-03
GO:BP	GO:0060977	coronary vasculature morphogenesis	15	17	1.59e-03
GO:BP	GO:0055023	positive regulation of cardiac muscle tissue growth	20	25	1.60e-03
GO:BP	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	79	138	1.60e-03
GO:BP	GO:0043254	regulation of protein-containing complex assembly	168	327	1.62e-03
GO:BP	GO:0002791	regulation of peptide secretion	76	132	1.67e-03
GO:BP	GO:0014855	striated muscle cell proliferation	39	59	1.67e-03
GO:BP	GO:0072009	nephron epithelium development	52	84	1.70e-03
GO:BP	GO:0061387	regulation of extent of cell growth	54	88	1.76e-03
GO:BP	GO:0061614	miRNA transcription	40	61	1.78e-03
GO:BP	GO:0032870	cellular response to hormone stimulus	216	433	1.81e-03
GO:BP	GO:0140115	export across plasma membrane	33	48	1.81e-03
GO:BP	GO:0010721	negative regulation of cell development	100	182	1.83e-03
GO:BP	GO:0031503	protein-containing complex localization	88	157	1.83e-03
GO:BP	GO:0007043	cell-cell junction assembly	63	106	1.83e-03
GO:BP	GO:0038127	ERBB signaling pathway	62	104	1.83e-03
GO:BP	GO:0001658	branching involved in ureteric bud morphogenesis	28	39	1.85e-03
GO:BP	GO:0050922	negative regulation of chemotaxis	28	39	1.85e-03
GO:BP	GO:0097061	dendritic spine organization	41	63	1.85e-03
GO:BP	GO:0007492	endoderm development	41	63	1.85e-03
GO:BP	GO:0070482	response to oxygen levels	139	265	1.85e-03
GO:BP	GO:1902284	neuron projection extension involved in neuron projection guidance	24	32	1.90e-03
GO:BP	GO:0048846	axon extension involved in axon guidance	24	32	1.90e-03
GO:BP	GO:0008361	regulation of cell size	83	147	2.00e-03
GO:BP	GO:0003148	outflow tract septum morphogenesis	18	22	2.09e-03
GO:BP	GO:0060045	positive regulation of cardiac muscle cell proliferation	18	22	2.09e-03
GO:BP	GO:1903779	regulation of cardiac conduction	18	22	2.09e-03
GO:BP	GO:1905330	regulation of morphogenesis of an epithelium	29	41	2.12e-03
GO:BP	GO:0051493	regulation of cytoskeleton organization	206	412	2.14e-03
GO:BP	GO:0106027	neuron projection organization	45	71	2.17e-03
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	77	135	2.22e-03
GO:BP	GO:0046883	regulation of hormone secretion	91	164	2.24e-03
GO:BP	GO:0014910	regulation of smooth muscle cell migration	36	54	2.29e-03
GO:BP	GO:0060541	respiratory system development	90	162	2.29e-03
GO:BP	GO:0071868	cellular response to monoamine stimulus	25	34	2.29e-03
GO:BP	GO:0071870	cellular response to catecholamine stimulus	25	34	2.29e-03
GO:BP	GO:0001764	neuron migration	74	129	2.30e-03
GO:BP	GO:0120031	plasma membrane bounded cell projection assembly	217	437	2.37e-03
GO:BP	GO:0072175	epithelial tube formation	68	117	2.48e-03
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	115	215	2.49e-03
GO:BP	GO:0048640	negative regulation of developmental growth	52	85	2.50e-03
GO:BP	GO:0032231	regulation of actin filament bundle assembly	52	85	2.50e-03
GO:BP	GO:0045446	endothelial cell differentiation	52	85	2.50e-03
GO:BP	GO:0050865	regulation of cell activation	176	347	2.52e-03
GO:BP	GO:0014020	primary neural tube formation	53	87	2.52e-03
GO:BP	GO:0043500	muscle adaptation	54	89	2.54e-03
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	64	109	2.54e-03
GO:BP	GO:0007009	plasma membrane organization	63	107	2.55e-03
GO:BP	GO:0008217	regulation of blood pressure	62	105	2.56e-03
GO:BP	GO:0002028	regulation of sodium ion transport	38	58	2.56e-03
GO:BP	GO:0007265	Ras protein signal transduction	57	95	2.56e-03
GO:BP	GO:1902105	regulation of leukocyte differentiation	105	194	2.58e-03
GO:BP	GO:0007520	myoblast fusion	22	29	2.65e-03
GO:BP	GO:0150117	positive regulation of cell-substrate junction organization	22	29	2.65e-03
GO:BP	GO:0003203	endocardial cushion morphogenesis	26	36	2.65e-03
GO:BP	GO:0010463	mesenchymal cell proliferation	26	36	2.65e-03
GO:BP	GO:0051703	biological process involved in intraspecies interaction between organisms	22	29	2.65e-03
GO:BP	GO:0061384	heart trabecula morphogenesis	22	29	2.65e-03
GO:BP	GO:0035176	social behavior	22	29	2.65e-03
GO:BP	GO:0071867	response to monoamine	26	36	2.65e-03
GO:BP	GO:0071869	response to catecholamine	26	36	2.65e-03
GO:BP	GO:0035418	protein localization to synapse	39	60	2.65e-03
GO:BP	GO:0014909	smooth muscle cell migration	39	60	2.65e-03
GO:BP	GO:0018209	peptidyl-serine modification	93	169	2.71e-03
GO:BP	GO:0032878	regulation of establishment or maintenance of cell polarity	19	24	2.85e-03
GO:BP	GO:0003299	muscle hypertrophy in response to stress	19	24	2.85e-03
GO:BP	GO:0014898	cardiac muscle hypertrophy in response to stress	19	24	2.85e-03
GO:BP	GO:0014887	cardiac muscle adaptation	19	24	2.85e-03
GO:BP	GO:0021700	developmental maturation	109	203	2.88e-03
GO:BP	GO:0050772	positive regulation of axonogenesis	41	64	2.89e-03
GO:BP	GO:0010594	regulation of endothelial cell migration	77	136	2.89e-03
GO:BP	GO:0090087	regulation of peptide transport	76	134	2.94e-03
GO:BP	GO:0030239	myofibril assembly	42	66	2.99e-03
GO:BP	GO:0030111	regulation of Wnt signaling pathway	136	261	2.99e-03
GO:BP	GO:0051641	cellular localization	1157	2623	3.01e-03
GO:BP	GO:0090276	regulation of peptide hormone secretion	74	130	3.04e-03
GO:BP	GO:0060420	regulation of heart growth	33	49	3.05e-03
GO:BP	GO:0070168	negative regulation of biomineral tissue development	14	16	3.05e-03
GO:BP	GO:0072080	nephron tubule development	44	70	3.17e-03
GO:BP	GO:0014812	muscle cell migration	45	72	3.25e-03
GO:BP	GO:2000628	regulation of miRNA metabolic process	45	72	3.25e-03
GO:BP	GO:0002274	myeloid leukocyte activation	68	118	3.31e-03
GO:BP	GO:0051963	regulation of synapse assembly	47	76	3.38e-03
GO:BP	GO:0050773	regulation of dendrite development	48	78	3.44e-03
GO:BP	GO:0050817	coagulation	82	147	3.47e-03
GO:BP	GO:0001508	action potential	60	102	3.57e-03
GO:BP	GO:0007173	epidermal growth factor receptor signaling pathway	52	86	3.58e-03
GO:BP	GO:0043069	negative regulation of programmed cell death	307	642	3.58e-03
GO:BP	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	55	92	3.60e-03
GO:BP	GO:0001841	neural tube formation	55	92	3.60e-03
GO:BP	GO:0030098	lymphocyte differentiation	130	249	3.60e-03
GO:BP	GO:0010657	muscle cell apoptotic process	36	55	3.69e-03
GO:BP	GO:1902656	calcium ion import into cytosol	20	26	3.70e-03
GO:BP	GO:1901653	cellular response to peptide	141	273	3.75e-03
GO:BP	GO:0032924	activin receptor signaling pathway	24	33	3.82e-03
GO:BP	GO:0019725	cellular homeostasis	272	564	4.09e-03
GO:BP	GO:0086002	cardiac muscle cell action potential involved in contraction	30	44	4.16e-03
GO:BP	GO:0034103	regulation of tissue remodeling	30	44	4.16e-03
GO:BP	GO:0055021	regulation of cardiac muscle tissue growth	30	44	4.16e-03
GO:BP	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	39	61	4.23e-03
GO:BP	GO:0022409	positive regulation of cell-cell adhesion	95	175	4.23e-03
GO:BP	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	71	125	4.28e-03
GO:BP	GO:0008284	positive regulation of cell population proliferation	290	605	4.28e-03
GO:BP	GO:0002694	regulation of leukocyte activation	159	313	4.33e-03
GO:BP	GO:0019933	cAMP-mediated signaling	25	35	4.41e-03
GO:BP	GO:0009952	anterior/posterior pattern specification	69	121	4.41e-03
GO:BP	GO:0046622	positive regulation of organ growth	25	35	4.41e-03
GO:BP	GO:2000116	regulation of cysteine-type endopeptidase activity	69	121	4.41e-03
GO:BP	GO:0051651	maintenance of location in cell	93	171	4.44e-03
GO:BP	GO:0061351	neural precursor cell proliferation	68	119	4.46e-03
GO:BP	GO:1990778	protein localization to cell periphery	147	287	4.46e-03
GO:BP	GO:0030316	osteoclast differentiation	41	65	4.46e-03
GO:BP	GO:0003197	endocardial cushion development	31	46	4.47e-03
GO:BP	GO:0048705	skeletal system morphogenesis	82	148	4.48e-03
GO:BP	GO:0030323	respiratory tube development	82	148	4.48e-03
GO:BP	GO:0007599	hemostasis	82	148	4.48e-03
GO:BP	GO:0036465	synaptic vesicle recycling	42	67	4.55e-03
GO:BP	GO:0051588	regulation of neurotransmitter transport	42	67	4.55e-03
GO:BP	GO:0003171	atrioventricular valve development	21	28	4.55e-03
GO:BP	GO:0048841	regulation of axon extension involved in axon guidance	21	28	4.55e-03
GO:BP	GO:0050796	regulation of insulin secretion	65	113	4.61e-03
GO:BP	GO:0043547	positive regulation of GTPase activity	65	113	4.61e-03
GO:BP	GO:0018107	peptidyl-threonine phosphorylation	43	69	4.64e-03
GO:BP	GO:0007596	blood coagulation	80	144	4.66e-03
GO:BP	GO:0030324	lung development	80	144	4.66e-03
GO:BP	GO:0031102	neuron projection regeneration	32	48	4.75e-03
GO:BP	GO:0048592	eye morphogenesis	62	107	4.77e-03
GO:BP	GO:0097581	lamellipodium organization	45	73	4.79e-03
GO:BP	GO:0042110	T cell activation	155	305	4.84e-03
GO:BP	GO:1903319	positive regulation of protein maturation	15	18	4.86e-03
GO:BP	GO:0042063	gliogenesis	126	242	4.89e-03
GO:BP	GO:0030517	negative regulation of axon extension	26	37	4.89e-03
GO:BP	GO:0010658	striated muscle cell apoptotic process	26	37	4.89e-03
GO:BP	GO:0010660	regulation of muscle cell apoptotic process	33	50	4.97e-03
GO:BP	GO:0030326	embryonic limb morphogenesis	52	87	4.97e-03
GO:BP	GO:1901019	regulation of calcium ion transmembrane transporter activity	33	50	4.97e-03
GO:BP	GO:0048814	regulation of dendrite morphogenesis	33	50	4.97e-03
GO:BP	GO:0031623	receptor internalization	53	89	4.97e-03
GO:BP	GO:0030038	contractile actin filament bundle assembly	54	91	4.97e-03
GO:BP	GO:0110053	regulation of actin filament organization	112	212	4.97e-03
GO:BP	GO:0033135	regulation of peptidyl-serine phosphorylation	51	85	4.97e-03
GO:BP	GO:0043149	stress fiber assembly	54	91	4.97e-03
GO:BP	GO:0035113	embryonic appendage morphogenesis	52	87	4.97e-03
GO:BP	GO:0010765	positive regulation of sodium ion transport	18	23	4.99e-03
GO:BP	GO:0048668	collateral sprouting	18	23	4.99e-03
GO:BP	GO:0035051	cardiocyte differentiation	74	132	5.22e-03
GO:BP	GO:0032906	transforming growth factor beta2 production	9	9	5.23e-03
GO:BP	GO:0032909	regulation of transforming growth factor beta2 production	9	9	5.23e-03
GO:BP	GO:1900024	regulation of substrate adhesion-dependent cell spreading	34	52	5.24e-03
GO:BP	GO:1904427	positive regulation of calcium ion transmembrane transport	34	52	5.24e-03
GO:BP	GO:0050678	regulation of epithelial cell proliferation	129	249	5.34e-03
GO:BP	GO:0035924	cellular response to vascular endothelial growth factor stimulus	35	54	5.50e-03
GO:BP	GO:0086065	cell communication involved in cardiac conduction	35	54	5.50e-03
GO:BP	GO:0001666	response to hypoxia	121	232	5.67e-03
GO:BP	GO:0043066	negative regulation of apoptotic process	295	619	5.73e-03
GO:BP	GO:0046928	regulation of neurotransmitter secretion	36	56	5.75e-03
GO:BP	GO:0051251	positive regulation of lymphocyte activation	99	185	5.84e-03
GO:BP	GO:0010812	negative regulation of cell-substrate adhesion	28	41	5.92e-03
GO:BP	GO:0008543	fibroblast growth factor receptor signaling pathway	37	58	5.96e-03
GO:BP	GO:0032414	positive regulation of ion transmembrane transporter activity	37	58	5.96e-03
GO:BP	GO:0001935	endothelial cell proliferation	65	114	6.14e-03
GO:BP	GO:0010001	glial cell differentiation	97	181	6.19e-03
GO:BP	GO:0098703	calcium ion import across plasma membrane	19	25	6.39e-03
GO:BP	GO:0072578	neurotransmitter-gated ion channel clustering	11	12	6.42e-03
GO:BP	GO:0003222	ventricular trabecula myocardium morphogenesis	11	12	6.42e-03
GO:BP	GO:0009880	embryonic pattern specification	29	43	6.42e-03
GO:BP	GO:0032332	positive regulation of chondrocyte differentiation	11	12	6.42e-03
GO:BP	GO:0001701	in utero embryonic development	166	331	6.51e-03
GO:BP	GO:0001570	vasculogenesis	41	66	6.61e-03
GO:BP	GO:0002040	sprouting angiogenesis	57	98	6.81e-03
GO:BP	GO:0046620	regulation of organ growth	43	70	6.82e-03
GO:BP	GO:0016079	synaptic vesicle exocytosis	43	70	6.82e-03
GO:BP	GO:0055123	digestive system development	56	96	6.85e-03
GO:BP	GO:0060997	dendritic spine morphogenesis	30	45	6.87e-03
GO:BP	GO:0030516	regulation of axon extension	45	74	6.96e-03
GO:BP	GO:0048565	digestive tract development	52	88	7.03e-03
GO:BP	GO:0050867	positive regulation of cell activation	107	203	7.03e-03
GO:BP	GO:0010659	cardiac muscle cell apoptotic process	24	34	7.03e-03
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	560	1231	7.03e-03
GO:BP	GO:0010662	regulation of striated muscle cell apoptotic process	24	34	7.03e-03
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	107	203	7.03e-03
GO:BP	GO:0060606	tube closure	50	84	7.03e-03
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	49	82	7.03e-03
GO:BP	GO:0043114	regulation of vascular permeability	24	34	7.03e-03
GO:BP	GO:0140747	regulation of ncRNA transcription	48	80	7.03e-03
GO:BP	GO:0032330	regulation of chondrocyte differentiation	24	34	7.03e-03
GO:BP	GO:0003230	cardiac atrium development	24	34	7.03e-03
GO:BP	GO:0071496	cellular response to external stimulus	137	268	7.13e-03
GO:BP	GO:0051249	regulation of lymphocyte activation	142	279	7.24e-03
GO:BP	GO:0045860	positive regulation of protein kinase activity	98	184	7.44e-03
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	561	1234	7.44e-03
GO:BP	GO:1903053	regulation of extracellular matrix organization	32	49	7.64e-03
GO:BP	GO:1901021	positive regulation of calcium ion transmembrane transporter activity	20	27	7.65e-03
GO:BP	GO:0070570	regulation of neuron projection regeneration	20	27	7.65e-03
GO:BP	GO:0031279	regulation of cyclase activity	20	27	7.65e-03
GO:BP	GO:0002696	positive regulation of leukocyte activation	104	197	7.69e-03
GO:BP	GO:1903037	regulation of leukocyte cell-cell adhesion	104	197	7.69e-03
GO:BP	GO:0038084	vascular endothelial growth factor signaling pathway	25	36	7.83e-03
GO:BP	GO:0051254	positive regulation of RNA metabolic process	612	1354	8.15e-03
GO:BP	GO:0043367	CD4-positive, alpha-beta T cell differentiation	34	53	8.32e-03
GO:BP	GO:0060491	regulation of cell projection assembly	86	159	8.32e-03
GO:BP	GO:0120032	regulation of plasma membrane bounded cell projection assembly	85	157	8.56e-03
GO:BP	GO:0003073	regulation of systemic arterial blood pressure	35	55	8.63e-03
GO:BP	GO:0036293	response to decreased oxygen levels	125	243	8.83e-03
GO:BP	GO:0055007	cardiac muscle cell differentiation	60	105	8.84e-03
GO:BP	GO:0021954	central nervous system neuron development	36	57	8.88e-03
GO:BP	GO:0051899	membrane depolarization	36	57	8.88e-03
GO:BP	GO:0140239	postsynaptic endocytosis	14	17	8.95e-03
GO:BP	GO:0048169	regulation of long-term neuronal synaptic plasticity	14	17	8.95e-03
GO:BP	GO:0002433	immune response-regulating cell surface receptor signaling pathway involved in phagocytosis	14	17	8.95e-03
GO:BP	GO:0098884	postsynaptic neurotransmitter receptor internalization	14	17	8.95e-03
GO:BP	GO:0051590	positive regulation of neurotransmitter transport	14	17	8.95e-03
GO:BP	GO:0060445	branching involved in salivary gland morphogenesis	14	17	8.95e-03
GO:BP	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	14	17	8.95e-03
GO:BP	GO:0097106	postsynaptic density organization	21	29	8.96e-03
GO:BP	GO:0062013	positive regulation of small molecule metabolic process	57	99	9.15e-03
GO:BP	GO:0035249	synaptic transmission, glutamatergic	38	61	9.23e-03
GO:BP	GO:0072091	regulation of stem cell proliferation	38	61	9.23e-03
GO:BP	GO:0035567	non-canonical Wnt signaling pathway	38	61	9.23e-03
GO:BP	GO:0006950	response to stress	1114	2540	9.26e-03
GO:BP	GO:0050795	regulation of behavior	27	40	9.26e-03
GO:BP	GO:0032411	positive regulation of transporter activity	39	63	9.37e-03
GO:BP	GO:0086001	cardiac muscle cell action potential	39	63	9.37e-03
GO:BP	GO:0055117	regulation of cardiac muscle contraction	40	65	9.52e-03
GO:BP	GO:0006887	exocytosis	122	237	9.60e-03
GO:BP	GO:0010595	positive regulation of endothelial cell migration	52	89	9.60e-03
GO:BP	GO:0001892	embryonic placenta development	41	67	9.61e-03
GO:BP	GO:0030534	adult behavior	51	87	9.64e-03
GO:BP	GO:0048593	camera-type eye morphogenesis	51	87	9.64e-03
GO:BP	GO:0110020	regulation of actomyosin structure organization	51	87	9.64e-03
GO:BP	GO:0001843	neural tube closure	49	83	9.76e-03
GO:BP	GO:0003014	renal system process	44	73	9.79e-03
GO:BP	GO:0051492	regulation of stress fiber assembly	46	77	9.80e-03
GO:BP	GO:0044344	cellular response to fibroblast growth factor stimulus	47	79	9.80e-03
GO:BP	GO:0001954	positive regulation of cell-matrix adhesion	28	42	9.84e-03
GO:BP	GO:0019229	regulation of vasoconstriction	28	42	9.84e-03
GO:BP	GO:0043434	response to peptide hormone	157	314	1.00e-02
GO:BP	GO:0010644	cell communication by electrical coupling	22	31	1.01e-02
GO:BP	GO:0010665	regulation of cardiac muscle cell apoptotic process	22	31	1.01e-02
GO:BP	GO:0030307	positive regulation of cell growth	67	120	1.01e-02
GO:BP	GO:1903351	cellular response to dopamine	22	31	1.01e-02
GO:BP	GO:1902895	positive regulation of miRNA transcription	29	44	1.04e-02
GO:BP	GO:0034332	adherens junction organization	29	44	1.04e-02
GO:BP	GO:0045859	regulation of protein kinase activity	165	332	1.05e-02
GO:BP	GO:0051894	positive regulation of focal adhesion assembly	18	24	1.08e-02
GO:BP	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	18	24	1.08e-02
GO:BP	GO:0045124	regulation of bone resorption	18	24	1.08e-02
GO:BP	GO:0060350	endochondral bone morphogenesis	30	46	1.10e-02
GO:BP	GO:0001890	placenta development	62	110	1.11e-02
GO:BP	GO:0097529	myeloid leukocyte migration	62	110	1.11e-02
GO:BP	GO:0098969	neurotransmitter receptor transport to postsynaptic membrane	12	14	1.11e-02
GO:BP	GO:0003190	atrioventricular valve formation	8	8	1.11e-02
GO:BP	GO:0032634	interleukin-5 production	8	8	1.11e-02
GO:BP	GO:1903540	establishment of protein localization to postsynaptic membrane	12	14	1.11e-02
GO:BP	GO:0060896	neural plate pattern specification	8	8	1.11e-02
GO:BP	GO:0060982	coronary artery morphogenesis	8	8	1.11e-02
GO:BP	GO:0003418	growth plate cartilage chondrocyte differentiation	8	8	1.11e-02
GO:BP	GO:0032674	regulation of interleukin-5 production	8	8	1.11e-02
GO:BP	GO:0051051	negative regulation of transport	144	286	1.11e-02
GO:BP	GO:0072659	protein localization to plasma membrane	122	238	1.13e-02
GO:BP	GO:0009410	response to xenobiotic stimulus	138	273	1.14e-02
GO:BP	GO:0060326	cell chemotaxis	82	152	1.14e-02
GO:BP	GO:1902903	regulation of supramolecular fiber organization	152	304	1.17e-02
GO:BP	GO:2000630	positive regulation of miRNA metabolic process	32	50	1.18e-02
GO:BP	GO:1990806	ligand-gated ion channel signaling pathway	15	19	1.20e-02
GO:BP	GO:0099637	neurotransmitter receptor transport	15	19	1.20e-02
GO:BP	GO:0099590	neurotransmitter receptor internalization	15	19	1.20e-02
GO:BP	GO:0098810	neurotransmitter reuptake	15	19	1.20e-02
GO:BP	GO:0009725	response to hormone	288	610	1.21e-02
GO:BP	GO:0001708	cell fate specification	33	52	1.22e-02
GO:BP	GO:0008038	neuron recognition	24	35	1.23e-02
GO:BP	GO:0007605	sensory perception of sound	55	96	1.25e-02
GO:BP	GO:0060143	positive regulation of syncytium formation by plasma membrane fusion	10	11	1.27e-02
GO:BP	GO:0051923	sulfation	10	11	1.27e-02
GO:BP	GO:0021670	lateral ventricle development	10	11	1.27e-02
GO:BP	GO:0045055	regulated exocytosis	78	144	1.27e-02
GO:BP	GO:0003209	cardiac atrium morphogenesis	19	26	1.27e-02
GO:BP	GO:0003181	atrioventricular valve morphogenesis	19	26	1.27e-02
GO:BP	GO:1903055	positive regulation of extracellular matrix organization	19	26	1.27e-02
GO:BP	GO:0032941	secretion by tissue	19	26	1.27e-02
GO:BP	GO:0051047	positive regulation of secretion	106	204	1.29e-02
GO:BP	GO:0010469	regulation of signaling receptor activity	36	58	1.30e-02
GO:BP	GO:0043542	endothelial cell migration	92	174	1.33e-02
GO:BP	GO:0008366	axon ensheathment	66	119	1.33e-02
GO:BP	GO:0007272	ensheathment of neurons	66	119	1.33e-02
GO:BP	GO:1902305	regulation of sodium ion transmembrane transport	25	37	1.33e-02
GO:BP	GO:0098661	inorganic anion transmembrane transport	38	62	1.34e-02
GO:BP	GO:0070167	regulation of biomineral tissue development	38	62	1.34e-02
GO:BP	GO:0071774	response to fibroblast growth factor	48	82	1.34e-02
GO:BP	GO:0150104	transport across blood-brain barrier	41	68	1.36e-02
GO:BP	GO:0071887	leukocyte apoptotic process	45	76	1.36e-02
GO:BP	GO:0018210	peptidyl-threonine modification	45	76	1.36e-02
GO:BP	GO:0097191	extrinsic apoptotic signaling pathway	91	172	1.36e-02
GO:BP	GO:0010232	vascular transport	41	68	1.36e-02
GO:BP	GO:0042552	myelination	65	117	1.36e-02
GO:BP	GO:0035710	CD4-positive, alpha-beta T cell activation	40	66	1.36e-02
GO:BP	GO:0097306	cellular response to alcohol	44	74	1.36e-02
GO:BP	GO:0046578	regulation of Ras protein signal transduction	26	39	1.42e-02
GO:BP	GO:0051965	positive regulation of synapse assembly	26	39	1.42e-02
GO:BP	GO:0052548	regulation of endopeptidase activity	82	153	1.42e-02
GO:BP	GO:0070374	positive regulation of ERK1 and ERK2 cascade	62	111	1.44e-02
GO:BP	GO:0048713	regulation of oligodendrocyte differentiation	20	28	1.45e-02
GO:BP	GO:0030705	cytoskeleton-dependent intracellular transport	94	179	1.54e-02
GO:BP	GO:0060041	retina development in camera-type eye	59	105	1.54e-02
GO:BP	GO:0032814	regulation of natural killer cell activation	13	16	1.63e-02
GO:BP	GO:0021846	cell proliferation in forebrain	13	16	1.63e-02
GO:BP	GO:0030041	actin filament polymerization	68	124	1.64e-02
GO:BP	GO:0021953	central nervous system neuron differentiation	56	99	1.64e-02
GO:BP	GO:0007616	long-term memory	21	30	1.64e-02
GO:BP	GO:0046850	regulation of bone remodeling	21	30	1.64e-02
GO:BP	GO:0001937	negative regulation of endothelial cell proliferation	21	30	1.64e-02
GO:BP	GO:0048512	circadian behavior	21	30	1.64e-02
GO:BP	GO:0060914	heart formation	21	30	1.64e-02
GO:BP	GO:0008277	regulation of G protein-coupled receptor signaling pathway	55	97	1.66e-02
GO:BP	GO:0010038	response to metal ion	126	249	1.67e-02
GO:BP	GO:0045926	negative regulation of growth	96	184	1.77e-02
GO:BP	GO:0045685	regulation of glial cell differentiation	31	49	1.77e-02
GO:BP	GO:0060711	labyrinthine layer development	22	32	1.81e-02
GO:BP	GO:0062237	protein localization to postsynapse	22	32	1.81e-02
GO:BP	GO:1903539	protein localization to postsynaptic membrane	22	32	1.81e-02
GO:BP	GO:0010656	negative regulation of muscle cell apoptotic process	22	32	1.81e-02
GO:BP	GO:1903350	response to dopamine	22	32	1.81e-02
GO:BP	GO:0007622	rhythmic behavior	22	32	1.81e-02
GO:BP	GO:0030168	platelet activation	50	87	1.81e-02
GO:BP	GO:0010586	miRNA metabolic process	50	87	1.81e-02
GO:BP	GO:0010876	lipid localization	148	298	1.81e-02
GO:BP	GO:0010664	negative regulation of striated muscle cell apoptotic process	17	23	1.83e-02
GO:BP	GO:0048843	negative regulation of axon extension involved in axon guidance	17	23	1.83e-02
GO:BP	GO:0002063	chondrocyte development	17	23	1.83e-02
GO:BP	GO:0060037	pharyngeal system development	17	23	1.83e-02
GO:BP	GO:0045761	regulation of adenylate cyclase activity	17	23	1.83e-02
GO:BP	GO:0045834	positive regulation of lipid metabolic process	48	83	1.83e-02
GO:BP	GO:0034763	negative regulation of transmembrane transport	48	83	1.83e-02
GO:BP	GO:0046847	filopodium assembly	33	53	1.84e-02
GO:BP	GO:0003006	developmental process involved in reproduction	270	573	1.86e-02
GO:BP	GO:0070509	calcium ion import	34	55	1.87e-02
GO:BP	GO:0042476	odontogenesis	46	79	1.87e-02
GO:BP	GO:0043393	regulation of protein binding	62	112	1.88e-02
GO:BP	GO:1901184	regulation of ERBB signaling pathway	35	57	1.89e-02
GO:BP	GO:0071260	cellular response to mechanical stimulus	35	57	1.89e-02
GO:BP	GO:0046849	bone remodeling	36	59	1.91e-02
GO:BP	GO:0048145	regulation of fibroblast proliferation	43	73	1.91e-02
GO:BP	GO:0043535	regulation of blood vessel endothelial cell migration	42	71	1.92e-02
GO:BP	GO:0051928	positive regulation of calcium ion transport	42	71	1.92e-02
GO:BP	GO:0099084	postsynaptic specialization organization	23	34	1.94e-02
GO:BP	GO:0051592	response to calcium ion	60	108	1.96e-02
GO:BP	GO:0006869	lipid transport	131	261	1.96e-02
GO:BP	GO:1903039	positive regulation of leukocyte cell-cell adhesion	78	146	1.98e-02
GO:BP	GO:1901652	response to peptide	179	368	2.05e-02
GO:BP	GO:0051246	regulation of protein metabolic process	709	1595	2.05e-02
GO:BP	GO:0030902	hindbrain development	58	104	2.05e-02
GO:BP	GO:0022607	cellular component assembly	1009	2305	2.05e-02
GO:BP	GO:2001259	positive regulation of cation channel activity	24	36	2.07e-02
GO:BP	GO:0048662	negative regulation of smooth muscle cell proliferation	24	36	2.07e-02
GO:BP	GO:1902904	negative regulation of supramolecular fiber organization	68	125	2.07e-02
GO:BP	GO:0002763	positive regulation of myeloid leukocyte differentiation	24	36	2.07e-02
GO:BP	GO:1904019	epithelial cell apoptotic process	57	102	2.09e-02
GO:BP	GO:0001956	positive regulation of neurotransmitter secretion	11	13	2.09e-02
GO:BP	GO:0046321	positive regulation of fatty acid oxidation	11	13	2.09e-02
GO:BP	GO:0046579	positive regulation of Ras protein signal transduction	11	13	2.09e-02
GO:BP	GO:0060351	cartilage development involved in endochondral bone morphogenesis	18	25	2.10e-02
GO:BP	GO:0032232	negative regulation of actin filament bundle assembly	18	25	2.10e-02
GO:BP	GO:0038094	Fc-gamma receptor signaling pathway	14	18	2.11e-02
GO:BP	GO:0032925	regulation of activin receptor signaling pathway	14	18	2.11e-02
GO:BP	GO:0051968	positive regulation of synaptic transmission, glutamatergic	14	18	2.11e-02
GO:BP	GO:0043113	receptor clustering	25	38	2.18e-02
GO:BP	GO:0030217	T cell differentiation	95	183	2.18e-02
GO:BP	GO:0045103	intermediate filament-based process	25	38	2.18e-02
GO:BP	GO:0051480	regulation of cytosolic calcium ion concentration	25	38	2.18e-02
GO:BP	GO:0061024	membrane organization	292	625	2.20e-02
GO:BP	GO:1902905	positive regulation of supramolecular fiber organization	74	138	2.20e-02
GO:BP	GO:0072523	purine-containing compound catabolic process	65	119	2.22e-02
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	400	874	2.24e-02
GO:BP	GO:0001816	cytokine production	211	441	2.30e-02
GO:BP	GO:0021591	ventricular system development	19	27	2.38e-02
GO:BP	GO:0120033	negative regulation of plasma membrane bounded cell projection assembly	19	27	2.38e-02
GO:BP	GO:0010464	regulation of mesenchymal cell proliferation	19	27	2.38e-02
GO:BP	GO:0031334	positive regulation of protein-containing complex assembly	79	149	2.38e-02
GO:BP	GO:0018193	peptidyl-amino acid modification	261	555	2.42e-02
GO:BP	GO:0002682	regulation of immune system process	397	868	2.44e-02
GO:BP	GO:0001817	regulation of cytokine production	209	437	2.45e-02
GO:BP	GO:0072089	stem cell proliferation	48	84	2.46e-02
GO:BP	GO:0009261	ribonucleotide catabolic process	61	111	2.46e-02
GO:BP	GO:0070613	regulation of protein processing	28	44	2.46e-02
GO:BP	GO:0045664	regulation of neuron differentiation	70	130	2.47e-02
GO:BP	GO:0046129	purine ribonucleoside biosynthetic process	9	10	2.49e-02
GO:BP	GO:0002093	auditory receptor cell morphogenesis	9	10	2.49e-02
GO:BP	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	9	10	2.49e-02
GO:BP	GO:0030431	sleep	9	10	2.49e-02
GO:BP	GO:0042451	purine nucleoside biosynthetic process	9	10	2.49e-02
GO:BP	GO:0042455	ribonucleoside biosynthetic process	9	10	2.49e-02
GO:BP	GO:0045906	negative regulation of vasoconstriction	9	10	2.49e-02
GO:BP	GO:0071625	vocalization behavior	9	10	2.49e-02
GO:BP	GO:0099149	regulation of postsynaptic neurotransmitter receptor internalization	9	10	2.49e-02
GO:BP	GO:0022410	circadian sleep/wake cycle process	9	10	2.49e-02
GO:BP	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	15	20	2.60e-02
GO:BP	GO:0035024	negative regulation of Rho protein signal transduction	15	20	2.60e-02
GO:BP	GO:0031281	positive regulation of cyclase activity	15	20	2.60e-02
GO:BP	GO:2000114	regulation of establishment of cell polarity	15	20	2.60e-02
GO:BP	GO:0086005	ventricular cardiac muscle cell action potential	20	29	2.60e-02
GO:BP	GO:0086019	cell-cell signaling involved in cardiac conduction	20	29	2.60e-02
GO:BP	GO:0010761	fibroblast migration	31	50	2.61e-02
GO:BP	GO:0051606	detection of stimulus	58	105	2.62e-02
GO:BP	GO:0048709	oligodendrocyte differentiation	42	72	2.63e-02
GO:BP	GO:0055013	cardiac muscle cell development	42	72	2.63e-02
GO:BP	GO:0001558	regulation of cell growth	158	323	2.63e-02
GO:BP	GO:1904063	negative regulation of cation transmembrane transport	32	52	2.64e-02
GO:BP	GO:0042475	odontogenesis of dentin-containing tooth	33	54	2.66e-02
GO:BP	GO:0032835	glomerulus development	33	54	2.66e-02
GO:BP	GO:0033138	positive regulation of peptidyl-serine phosphorylation	35	58	2.70e-02
GO:BP	GO:0010565	regulation of cellular ketone metabolic process	55	99	2.81e-02
GO:BP	GO:0070296	sarcoplasmic reticulum calcium ion transport	21	31	2.81e-02
GO:BP	GO:0060391	positive regulation of SMAD protein signal transduction	21	31	2.81e-02
GO:BP	GO:0021955	central nervous system neuron axonogenesis	21	31	2.81e-02
GO:BP	GO:0050863	regulation of T cell activation	104	204	2.82e-02
GO:BP	GO:0009913	epidermal cell differentiation	64	118	2.89e-02
GO:BP	GO:0014047	glutamate secretion	12	15	2.89e-02
GO:BP	GO:1900242	regulation of synaptic vesicle endocytosis	12	15	2.89e-02
GO:BP	GO:0098877	neurotransmitter receptor transport to plasma membrane	12	15	2.89e-02
GO:BP	GO:0001759	organ induction	12	15	2.89e-02
GO:BP	GO:0003188	heart valve formation	12	15	2.89e-02
GO:BP	GO:1902932	positive regulation of alcohol biosynthetic process	12	15	2.89e-02
GO:BP	GO:0060571	morphogenesis of an epithelial fold	12	15	2.89e-02
GO:BP	GO:0097091	synaptic vesicle clustering	12	15	2.89e-02
GO:BP	GO:0009166	nucleotide catabolic process	72	135	2.89e-02
GO:BP	GO:0070571	negative regulation of neuron projection regeneration	12	15	2.89e-02
GO:BP	GO:0050870	positive regulation of T cell activation	72	135	2.89e-02
GO:BP	GO:0046128	purine ribonucleoside metabolic process	12	15	2.89e-02
GO:BP	GO:0090103	cochlea morphogenesis	12	15	2.89e-02
GO:BP	GO:0033993	response to lipid	268	573	2.92e-02
GO:BP	GO:0002684	positive regulation of immune system process	271	580	2.96e-02
GO:BP	GO:0008154	actin polymerization or depolymerization	78	148	2.98e-02
GO:BP	GO:0046635	positive regulation of alpha-beta T cell activation	22	33	2.98e-02
GO:BP	GO:0060343	trabecula formation	16	22	3.01e-02
GO:BP	GO:0002021	response to dietary excess	16	22	3.01e-02
GO:BP	GO:0030279	negative regulation of ossification	16	22	3.01e-02
GO:BP	GO:0048499	synaptic vesicle membrane organization	16	22	3.01e-02
GO:BP	GO:0000082	G1/S transition of mitotic cell cycle	95	185	3.13e-02
GO:BP	GO:0086091	regulation of heart rate by cardiac conduction	23	35	3.16e-02
GO:BP	GO:0015698	inorganic anion transport	48	85	3.24e-02
GO:BP	GO:2001056	positive regulation of cysteine-type endopeptidase activity	47	83	3.30e-02
GO:BP	GO:0015800	acidic amino acid transport	24	37	3.31e-02
GO:BP	GO:0045104	intermediate filament cytoskeleton organization	24	37	3.31e-02
GO:BP	GO:0046637	regulation of alpha-beta T cell differentiation	24	37	3.31e-02
GO:BP	GO:0014074	response to purine-containing compound	58	106	3.36e-02
GO:BP	GO:0009154	purine ribonucleotide catabolic process	58	106	3.36e-02
GO:BP	GO:0022011	myelination in peripheral nervous system	17	24	3.43e-02
GO:BP	GO:0048679	regulation of axon regeneration	17	24	3.43e-02
GO:BP	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	17	24	3.43e-02
GO:BP	GO:0032292	peripheral nervous system axon ensheathment	17	24	3.43e-02
GO:BP	GO:1905332	positive regulation of morphogenesis of an epithelium	17	24	3.43e-02
GO:BP	GO:0002431	Fc receptor mediated stimulatory signaling pathway	17	24	3.43e-02
GO:BP	GO:0060074	synapse maturation	17	24	3.43e-02
GO:BP	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	57	104	3.43e-02
GO:BP	GO:0046942	carboxylic acid transport	103	203	3.43e-02
GO:BP	GO:0043068	positive regulation of programmed cell death	186	388	3.44e-02
GO:BP	GO:0006909	phagocytosis	73	138	3.46e-02
GO:BP	GO:0007204	positive regulation of cytosolic calcium ion concentration	43	75	3.51e-02
GO:BP	GO:1990845	adaptive thermogenesis	65	121	3.51e-02
GO:BP	GO:0045453	bone resorption	26	41	3.51e-02
GO:BP	GO:0031103	axon regeneration	26	41	3.51e-02
GO:BP	GO:0030833	regulation of actin filament polymerization	56	102	3.51e-02
GO:BP	GO:0048871	multicellular organismal-level homeostasis	251	536	3.53e-02
GO:BP	GO:0060349	bone morphogenesis	42	73	3.55e-02
GO:BP	GO:0042093	T-helper cell differentiation	27	43	3.59e-02
GO:BP	GO:1903034	regulation of response to wounding	64	119	3.59e-02
GO:BP	GO:0002294	CD4-positive, alpha-beta T cell differentiation involved in immune response	27	43	3.59e-02
GO:BP	GO:0002293	alpha-beta T cell differentiation involved in immune response	27	43	3.59e-02
GO:BP	GO:0045214	sarcomere organization	27	43	3.59e-02
GO:BP	GO:0002287	alpha-beta T cell activation involved in immune response	27	43	3.59e-02
GO:BP	GO:0060392	negative regulation of SMAD protein signal transduction	13	17	3.65e-02
GO:BP	GO:0072673	lamellipodium morphogenesis	13	17	3.65e-02
GO:BP	GO:0048670	regulation of collateral sprouting	13	17	3.65e-02
GO:BP	GO:0042100	B cell proliferation	28	45	3.65e-02
GO:BP	GO:0061323	cell proliferation involved in heart morphogenesis	13	17	3.65e-02
GO:BP	GO:2000136	regulation of cell proliferation involved in heart morphogenesis	13	17	3.65e-02
GO:BP	GO:0043549	regulation of kinase activity	172	357	3.65e-02
GO:BP	GO:0050680	negative regulation of epithelial cell proliferation	54	98	3.66e-02
GO:BP	GO:0030099	myeloid cell differentiation	143	292	3.66e-02
GO:BP	GO:0002067	glandular epithelial cell differentiation	29	47	3.69e-02
GO:BP	GO:1903317	regulation of protein maturation	29	47	3.69e-02
GO:BP	GO:0060291	long-term synaptic potentiation	38	65	3.69e-02
GO:BP	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	18	26	3.72e-02
GO:BP	GO:0048678	response to axon injury	36	61	3.72e-02
GO:BP	GO:0010092	specification of animal organ identity	18	26	3.72e-02
GO:BP	GO:0060998	regulation of dendritic spine development	30	49	3.72e-02
GO:BP	GO:0033674	positive regulation of kinase activity	100	197	3.72e-02
GO:BP	GO:0032092	positive regulation of protein binding	30	49	3.72e-02
GO:BP	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	18	26	3.72e-02
GO:BP	GO:0007212	dopamine receptor signaling pathway	18	26	3.72e-02
GO:BP	GO:0001936	regulation of endothelial cell proliferation	53	96	3.72e-02
GO:BP	GO:0071621	granulocyte chemotaxis	30	49	3.72e-02
GO:BP	GO:0032271	regulation of protein polymerization	83	160	3.72e-02
GO:BP	GO:0042058	regulation of epidermal growth factor receptor signaling pathway	31	51	3.72e-02
GO:BP	GO:0043954	cellular component maintenance	34	57	3.73e-02
GO:BP	GO:0042310	vasoconstriction	33	55	3.73e-02
GO:BP	GO:0042116	macrophage activation	33	55	3.73e-02
GO:BP	GO:0007589	body fluid secretion	34	57	3.73e-02
GO:BP	GO:0030032	lamellipodium assembly	33	55	3.73e-02
GO:BP	GO:0036211	protein modification process	998	2291	3.75e-02
GO:BP	GO:0036302	atrioventricular canal development	10	12	3.76e-02
GO:BP	GO:0042326	negative regulation of phosphorylation	119	239	3.76e-02
GO:BP	GO:0045651	positive regulation of macrophage differentiation	10	12	3.76e-02
GO:BP	GO:0061154	endothelial tube morphogenesis	10	12	3.76e-02
GO:BP	GO:0033043	regulation of organelle organization	431	953	3.76e-02
GO:BP	GO:0048368	lateral mesoderm development	10	12	3.76e-02
GO:BP	GO:0071871	response to epinephrine	10	12	3.76e-02
GO:BP	GO:0045780	positive regulation of bone resorption	10	12	3.76e-02
GO:BP	GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis	10	12	3.76e-02
GO:BP	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	10	12	3.76e-02
GO:BP	GO:0043065	positive regulation of apoptotic process	182	380	3.76e-02
GO:BP	GO:0003159	morphogenesis of an endothelium	10	12	3.76e-02
GO:BP	GO:0099505	regulation of presynaptic membrane potential	10	12	3.76e-02
GO:BP	GO:0032516	positive regulation of phosphoprotein phosphatase activity	10	12	3.76e-02
GO:BP	GO:0006955	immune response	394	867	3.77e-02
GO:BP	GO:0022414	reproductive process	397	874	3.77e-02
GO:BP	GO:0007584	response to nutrient	61	113	3.79e-02
GO:BP	GO:0045936	negative regulation of phosphate metabolic process	141	288	3.81e-02
GO:BP	GO:0043534	blood vessel endothelial cell migration	51	92	3.82e-02
GO:BP	GO:1903532	positive regulation of secretion by cell	98	193	3.90e-02
GO:BP	GO:1903706	regulation of hemopoiesis	127	257	3.91e-02
GO:BP	GO:0001819	positive regulation of cytokine production	127	257	3.91e-02
GO:BP	GO:0015849	organic acid transport	103	204	3.92e-02
GO:BP	GO:0033036	macromolecule localization	1005	2309	3.96e-02
GO:BP	GO:1903514	release of sequestered calcium ion into cytosol by endoplasmic reticulum	19	28	3.96e-02
GO:BP	GO:0048483	autonomic nervous system development	19	28	3.96e-02
GO:BP	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	19	28	3.96e-02
GO:BP	GO:0001933	negative regulation of protein phosphorylation	112	224	4.04e-02
GO:BP	GO:0050905	neuromuscular process	58	107	4.11e-02
GO:BP	GO:0030595	leukocyte chemotaxis	58	107	4.11e-02
GO:BP	GO:0001503	ossification	147	302	4.13e-02
GO:BP	GO:0035270	endocrine system development	47	84	4.19e-02
GO:BP	GO:0003338	metanephros morphogenesis	14	19	4.23e-02
GO:BP	GO:0019934	cGMP-mediated signaling	14	19	4.23e-02
GO:BP	GO:0042278	purine nucleoside metabolic process	14	19	4.23e-02
GO:BP	GO:1901201	regulation of extracellular matrix assembly	14	19	4.23e-02
GO:BP	GO:0010878	cholesterol storage	14	19	4.23e-02
GO:BP	GO:0042092	type 2 immune response	14	19	4.23e-02
GO:BP	GO:0003156	regulation of animal organ formation	14	19	4.23e-02
GO:BP	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	14	19	4.23e-02
GO:BP	GO:0052652	cyclic purine nucleotide metabolic process	20	30	4.23e-02
GO:BP	GO:0062009	secondary palate development	14	19	4.23e-02
GO:BP	GO:0045621	positive regulation of lymphocyte differentiation	46	82	4.25e-02
GO:BP	GO:0007600	sensory perception	124	251	4.29e-02
GO:BP	GO:0010563	negative regulation of phosphorus metabolic process	141	289	4.36e-02
GO:BP	GO:0045637	regulation of myeloid cell differentiation	71	135	4.36e-02
GO:BP	GO:0042113	B cell activation	83	161	4.42e-02
GO:BP	GO:0032869	cellular response to insulin stimulus	83	161	4.42e-02
GO:BP	GO:0055006	cardiac cell development	44	78	4.42e-02
GO:BP	GO:0030282	bone mineralization	44	78	4.42e-02
GO:BP	GO:0031333	negative regulation of protein-containing complex assembly	63	118	4.47e-02
GO:BP	GO:0050714	positive regulation of protein secretion	54	99	4.56e-02
GO:BP	GO:1904018	positive regulation of vasculature development	62	116	4.61e-02
GO:BP	GO:0035272	exocrine system development	22	34	4.63e-02
GO:BP	GO:0030888	regulation of B cell proliferation	22	34	4.63e-02
GO:BP	GO:0090102	cochlea development	22	34	4.63e-02
GO:BP	GO:0060999	positive regulation of dendritic spine development	22	34	4.63e-02
GO:BP	GO:0043666	regulation of phosphoprotein phosphatase activity	22	34	4.63e-02
GO:BP	GO:0003161	cardiac conduction system development	22	34	4.63e-02
GO:BP	GO:0071711	basement membrane organization	22	34	4.63e-02
GO:BP	GO:0002793	positive regulation of peptide secretion	41	72	4.67e-02
GO:BP	GO:0097475	motor neuron migration	8	9	4.69e-02
GO:BP	GO:0003162	atrioventricular node development	8	9	4.69e-02
GO:BP	GO:0050802	circadian sleep/wake cycle, sleep	8	9	4.69e-02
GO:BP	GO:0071361	cellular response to ethanol	8	9	4.69e-02
GO:BP	GO:0060088	auditory receptor cell stereocilium organization	8	9	4.69e-02
GO:BP	GO:0061626	pharyngeal arch artery morphogenesis	8	9	4.69e-02
GO:BP	GO:0001768	establishment of T cell polarity	8	9	4.69e-02
GO:BP	GO:0038065	collagen-activated signaling pathway	8	9	4.69e-02
GO:BP	GO:0030162	regulation of proteolysis	197	416	4.69e-02
GO:BP	GO:0006195	purine nucleotide catabolic process	61	114	4.69e-02
GO:BP	GO:0045766	positive regulation of angiogenesis	61	114	4.69e-02
GO:BP	GO:0045862	positive regulation of proteolysis	121	245	4.69e-02
GO:BP	GO:0030593	neutrophil chemotaxis	23	36	4.75e-02
GO:BP	GO:0061001	regulation of dendritic spine morphogenesis	23	36	4.75e-02
GO:BP	GO:0060443	mammary gland morphogenesis	23	36	4.75e-02
GO:BP	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	6	6	4.75e-02
GO:BP	GO:0023041	neuronal signal transduction	6	6	4.75e-02
GO:BP	GO:0014912	negative regulation of smooth muscle cell migration	15	21	4.75e-02
GO:BP	GO:0032754	positive regulation of interleukin-5 production	6	6	4.75e-02
GO:BP	GO:0031223	auditory behavior	6	6	4.75e-02
GO:BP	GO:1903421	regulation of synaptic vesicle recycling	15	21	4.75e-02
GO:BP	GO:0072173	metanephric tubule morphogenesis	6	6	4.75e-02
GO:BP	GO:1903903	regulation of establishment of T cell polarity	6	6	4.75e-02
GO:BP	GO:0010737	protein kinase A signaling	15	21	4.75e-02
GO:BP	GO:0060710	chorio-allantoic fusion	6	6	4.75e-02
GO:BP	GO:0061037	negative regulation of cartilage development	15	21	4.75e-02
GO:BP	GO:0003433	chondrocyte development involved in endochondral bone morphogenesis	6	6	4.75e-02
GO:BP	GO:0099545	trans-synaptic signaling by trans-synaptic complex	6	6	4.75e-02
GO:BP	GO:0051639	actin filament network formation	6	6	4.75e-02
GO:BP	GO:0050679	positive regulation of epithelial cell proliferation	74	142	4.75e-02
GO:BP	GO:2000192	negative regulation of fatty acid transport	6	6	4.75e-02
GO:BP	GO:0014031	mesenchymal cell development	6	6	4.75e-02
GO:BP	GO:0050861	positive regulation of B cell receptor signaling pathway	6	6	4.75e-02
GO:BP	GO:0060897	neural plate regionalization	6	6	4.75e-02
GO:BP	GO:0003175	tricuspid valve development	6	6	4.75e-02
GO:BP	GO:0043502	regulation of muscle adaptation	39	68	4.75e-02
GO:BP	GO:0098976	excitatory chemical synaptic transmission	6	6	4.75e-02
GO:BP	GO:0003415	chondrocyte hypertrophy	6	6	4.75e-02
GO:BP	GO:0001771	immunological synapse formation	6	6	4.75e-02
GO:BP	GO:0045639	positive regulation of myeloid cell differentiation	38	66	4.77e-02
GO:BP	GO:0051098	regulation of binding	101	201	4.78e-02
GO:BP	GO:0048013	ephrin receptor signaling pathway	24	38	4.78e-02
GO:BP	GO:0051494	negative regulation of cytoskeleton organization	67	127	4.78e-02
GO:BP	GO:2001222	regulation of neuron migration	24	38	4.78e-02
GO:BP	GO:2000117	negative regulation of cysteine-type endopeptidase activity	24	38	4.78e-02
GO:BP	GO:0019217	regulation of fatty acid metabolic process	37	64	4.82e-02
GO:BP	GO:0038166	angiotensin-activated signaling pathway	11	14	4.84e-02
GO:BP	GO:0060142	regulation of syncytium formation by plasma membrane fusion	11	14	4.84e-02
GO:BP	GO:0010763	positive regulation of fibroblast migration	11	14	4.84e-02
GO:BP	GO:0002252	immune effector process	145	299	4.84e-02
GO:BP	GO:1901292	nucleoside phosphate catabolic process	73	140	4.84e-02
GO:BP	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	11	14	4.84e-02
GO:BP	GO:0050954	sensory perception of mechanical stimulus	59	110	4.84e-02
GO:BP	GO:0010885	regulation of cholesterol storage	11	14	4.84e-02
GO:BP	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter	11	14	4.84e-02
GO:BP	GO:0006835	dicarboxylic acid transport	35	60	4.91e-02
GO:BP	GO:0048146	positive regulation of fibroblast proliferation	26	42	4.93e-02
GO:BP	GO:0045123	cellular extravasation	26	42	4.93e-02
GO:BP	GO:0051489	regulation of filopodium assembly	26	42	4.93e-02
GO:BP	GO:0048144	fibroblast proliferation	49	89	4.98e-02
GO:BP	GO:0002042	cell migration involved in sprouting angiogenesis	27	44	4.98e-02
GO:BP	GO:0071695	anatomical structure maturation	78	151	4.99e-02

ESRnomtable_20k %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in ESR nESRgenes_20k") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in ESR nESRgenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:04510	Focal adhesion	113	169	2.81e-09
KEGG	KEGG:04020	Calcium signaling pathway	107	161	5.90e-09
KEGG	KEGG:04360	Axon guidance	104	155	5.90e-09
KEGG	KEGG:05200	Pathways in cancer	223	391	5.98e-09
KEGG	KEGG:04024	cAMP signaling pathway	98	147	1.47e-08
KEGG	KEGG:04015	Rap1 signaling pathway	106	162	1.47e-08
KEGG	KEGG:04925	Aldosterone synthesis and secretion	57	75	3.12e-08
KEGG	KEGG:05205	Proteoglycans in cancer	105	162	3.12e-08
KEGG	KEGG:04022	cGMP-PKG signaling pathway	84	129	8.83e-07
KEGG	KEGG:04724	Glutamatergic synapse	54	74	8.83e-07
KEGG	KEGG:05414	Dilated cardiomyopathy	58	82	1.48e-06
KEGG	KEGG:04261	Adrenergic signaling in cardiomyocytes	80	124	2.88e-06
KEGG	KEGG:04921	Oxytocin signaling pathway	74	113	2.99e-06
KEGG	KEGG:04911	Insulin secretion	46	62	2.99e-06
KEGG	KEGG:04270	Vascular smooth muscle contraction	62	92	6.32e-06
KEGG	KEGG:04310	Wnt signaling pathway	83	133	1.05e-05
KEGG	KEGG:04924	Renin secretion	38	50	1.06e-05
KEGG	KEGG:04810	Regulation of actin cytoskeleton	101	169	1.16e-05
KEGG	KEGG:05410	Hypertrophic cardiomyopathy	53	77	1.18e-05
KEGG	KEGG:04713	Circadian entrainment	48	68	1.18e-05
KEGG	KEGG:04919	Thyroid hormone signaling pathway	68	105	1.18e-05
KEGG	KEGG:04611	Platelet activation	59	88	1.18e-05
KEGG	KEGG:04927	Cortisol synthesis and secretion	35	46	2.12e-05
KEGG	KEGG:04512	ECM-receptor interaction	46	66	3.24e-05
KEGG	KEGG:04750	Inflammatory mediator regulation of TRP channels	49	72	4.35e-05
KEGG	KEGG:04014	Ras signaling pathway	96	164	5.46e-05
KEGG	KEGG:04726	Serotonergic synapse	41	58	5.82e-05
KEGG	KEGG:04725	Cholinergic synapse	54	82	5.84e-05
KEGG	KEGG:04971	Gastric acid secretion	37	51	5.94e-05
KEGG	KEGG:04934	Cushing syndrome	73	119	6.66e-05
KEGG	KEGG:04151	PI3K-Akt signaling pathway	137	250	7.18e-05
KEGG	KEGG:04520	Adherens junction	54	83	8.80e-05
KEGG	KEGG:04970	Salivary secretion	38	54	1.26e-04
KEGG	KEGG:04961	Endocrine and other factor-regulated calcium reabsorption	30	40	1.36e-04
KEGG	KEGG:04974	Protein digestion and absorption	39	56	1.36e-04
KEGG	KEGG:04728	Dopaminergic synapse	60	97	2.51e-04
KEGG	KEGG:04972	Pancreatic secretion	39	57	2.51e-04
KEGG	KEGG:04072	Phospholipase D signaling pathway	65	107	2.61e-04
KEGG	KEGG:04390	Hippo signaling pathway	76	129	2.61e-04
KEGG	KEGG:04670	Leukocyte transendothelial migration	49	76	2.63e-04
KEGG	KEGG:04929	GnRH secretion	35	50	2.70e-04
KEGG	KEGG:04010	MAPK signaling pathway	125	231	2.92e-04
KEGG	KEGG:05032	Morphine addiction	37	54	3.17e-04
KEGG	KEGG:05412	Arrhythmogenic right ventricular cardiomyopathy	44	67	3.17e-04
KEGG	KEGG:05206	MicroRNAs in cancer	82	144	6.05e-04
KEGG	KEGG:04928	Parathyroid hormone synthesis, secretion and action	49	78	6.17e-04
KEGG	KEGG:04915	Estrogen signaling pathway	55	90	6.81e-04
KEGG	KEGG:04926	Relaxin signaling pathway	60	100	6.92e-04
KEGG	KEGG:04730	Long-term depression	28	39	6.92e-04
KEGG	KEGG:04530	Tight junction	74	129	8.61e-04
KEGG	KEGG:05163	Human cytomegalovirus infection	89	160	8.61e-04
KEGG	KEGG:05165	Human papillomavirus infection	132	252	1.05e-03
KEGG	KEGG:04148	Efferocytosis	69	120	1.24e-03
KEGG	KEGG:04066	HIF-1 signaling pathway	52	86	1.31e-03
KEGG	KEGG:04371	Apelin signaling pathway	61	104	1.31e-03
KEGG	KEGG:04935	Growth hormone synthesis, secretion and action	57	96	1.31e-03
KEGG	KEGG:05225	Hepatocellular carcinoma	77	137	1.38e-03
KEGG	KEGG:04976	Bile secretion	28	41	2.24e-03
KEGG	KEGG:04923	Regulation of lipolysis in adipocytes	28	41	2.24e-03
KEGG	KEGG:05146	Amoebiasis	39	62	2.38e-03
KEGG	KEGG:05031	Amphetamine addiction	30	45	2.57e-03
KEGG	KEGG:04720	Long-term potentiation	33	51	3.03e-03
KEGG	KEGG:05226	Gastric cancer	64	113	3.09e-03
KEGG	KEGG:04933	AGE-RAGE signaling pathway in diabetic complications	51	87	3.68e-03
KEGG	KEGG:04916	Melanogenesis	45	75	3.70e-03
KEGG	KEGG:04814	Motor proteins	77	141	3.89e-03
KEGG	KEGG:00051	Fructose and mannose metabolism	19	26	4.90e-03
KEGG	KEGG:04659	Th17 cell differentiation	37	60	5.06e-03
KEGG	KEGG:04912	GnRH signaling pathway	44	74	5.12e-03
KEGG	KEGG:04922	Glucagon signaling pathway	46	78	5.12e-03
KEGG	KEGG:05224	Breast cancer	63	113	5.26e-03
KEGG	KEGG:04370	VEGF signaling pathway	30	47	6.43e-03
KEGG	KEGG:05100	Bacterial invasion of epithelial cells	43	73	6.96e-03
KEGG	KEGG:04012	ErbB signaling pathway	44	75	6.96e-03
KEGG	KEGG:04666	Fc gamma R-mediated phagocytosis	44	75	6.96e-03
KEGG	KEGG:05214	Glioma	39	65	6.96e-03
KEGG	KEGG:04540	Gap junction	42	71	6.96e-03
KEGG	KEGG:00000	KEGG root term	2317	5451	7.40e-03
KEGG	KEGG:04740	Olfactory transduction	18	25	7.53e-03
KEGG	KEGG:01522	Endocrine resistance	47	82	9.04e-03
KEGG	KEGG:04727	GABAergic synapse	32	52	9.64e-03
KEGG	KEGG:05230	Central carbon metabolism in cancer	35	58	9.77e-03
KEGG	KEGG:04152	AMPK signaling pathway	56	101	9.84e-03
KEGG	KEGG:05017	Spinocerebellar ataxia	65	120	9.89e-03
KEGG	KEGG:05131	Shigellosis	104	204	9.89e-03
KEGG	KEGG:04930	Type II diabetes mellitus	23	35	1.12e-02
KEGG	KEGG:04721	Synaptic vesicle cycle	30	49	1.35e-02
KEGG	KEGG:05207	Chemical carcinogenesis - receptor activation	70	132	1.35e-02
KEGG	KEGG:04910	Insulin signaling pathway	61	113	1.40e-02
KEGG	KEGG:04380	Osteoclast differentiation	51	92	1.40e-02
KEGG	KEGG:04350	TGF-beta signaling pathway	50	90	1.42e-02
KEGG	KEGG:05135	Yersinia infection	58	107	1.48e-02
KEGG	KEGG:05231	Choline metabolism in cancer	45	80	1.57e-02
KEGG	KEGG:05030	Cocaine addiction	21	32	1.60e-02
KEGG	KEGG:01521	EGFR tyrosine kinase inhibitor resistance	41	72	1.68e-02
KEGG	KEGG:00052	Galactose metabolism	15	21	1.71e-02
KEGG	KEGG:00512	Mucin type O-glycan biosynthesis	15	21	1.71e-02
KEGG	KEGG:04931	Insulin resistance	50	91	1.77e-02
KEGG	KEGG:04070	Phosphatidylinositol signaling system	46	83	1.96e-02
KEGG	KEGG:04060	Cytokine-cytokine receptor interaction	51	94	2.24e-02
KEGG	KEGG:04514	Cell adhesion molecules	39	69	2.29e-02
KEGG	KEGG:04973	Carbohydrate digestion and absorption	19	29	2.30e-02
KEGG	KEGG:05202	Transcriptional misregulation in cancer	64	122	2.32e-02
KEGG	KEGG:04071	Sphingolipid signaling pathway	55	103	2.46e-02
KEGG	KEGG:04650	Natural killer cell mediated cytotoxicity	31	53	2.54e-02
KEGG	KEGG:04625	C-type lectin receptor signaling pathway	41	74	2.85e-02
KEGG	KEGG:05211	Renal cell carcinoma	35	62	3.26e-02
KEGG	KEGG:04960	Aldosterone-regulated sodium reabsorption	16	24	3.26e-02
KEGG	KEGG:05210	Colorectal cancer	44	81	3.35e-02
KEGG	KEGG:04913	Ovarian steroidogenesis	17	26	3.35e-02
KEGG	KEGG:05218	Melanoma	32	56	3.39e-02
KEGG	KEGG:05418	Fluid shear stress and atherosclerosis	57	109	3.45e-02
KEGG	KEGG:04062	Chemokine signaling pathway	57	109	3.45e-02
KEGG	KEGG:04213	Longevity regulating pathway - multiple species	29	50	3.48e-02
KEGG	KEGG:05212	Pancreatic cancer	39	71	3.73e-02
KEGG	KEGG:04150	mTOR signaling pathway	66	129	3.73e-02
KEGG	KEGG:04550	Signaling pathways regulating pluripotency of stem cells	53	101	3.86e-02
KEGG	KEGG:05170	Human immunodeficiency virus 1 infection	75	149	3.88e-02
KEGG	KEGG:04260	Cardiac muscle contraction	35	63	4.04e-02
KEGG	KEGG:05222	Small cell lung cancer	44	82	4.04e-02
KEGG	KEGG:05167	Kaposi sarcoma-associated herpesvirus infection	68	134	4.07e-02
KEGG	KEGG:04614	Renin-angiotensin system	8	10	4.18e-02
KEGG	KEGG:05033	Nicotine addiction	8	10	4.18e-02
KEGG	KEGG:04340	Hedgehog signaling pathway	28	49	4.61e-02
KEGG	KEGG:05142	Chagas disease	39	72	4.61e-02
KEGG	KEGG:03320	PPAR signaling pathway	27	47	4.67e-02
KEGG	KEGG:04392	Hippo signaling pathway - multiple species	16	25	4.75e-02
KEGG	KEGG:05219	Bladder cancer	21	35	4.97e-02

ESR peaks overlapping enhancers

# ESR_resgenes_20k_enh <- gost(query = unique(ESR_enh_peaks_20k$NCBI_gene),
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(ESR_resgenes_20k_enh,"data/GO_KEGG_analysis/ESR_resgenes_20k_enh.RDS")


# ESRnom <- gostplot(ESR_resgenes_20k_enh, capped = FALSE, interactive = TRUE)
# ESRnom

ESRnomtable_20k_enh <- ESR_resgenes_20k_enh$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

ESRnomtable_20k_enh %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in ESR neargenes_20k" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in ESR neargenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0032501	multicellular organismal process	623	4504	2.35e-19
GO:BP	GO:0051239	regulation of multicellular organismal process	318	1924	1.69e-17
GO:BP	GO:0030154	cell differentiation	415	2803	1.63e-15
GO:BP	GO:0048856	anatomical structure development	536	3867	1.63e-15
GO:BP	GO:0048869	cellular developmental process	415	2804	1.63e-15
GO:BP	GO:0009653	anatomical structure morphogenesis	299	1844	2.56e-15
GO:BP	GO:0032502	developmental process	567	4179	4.03e-15
GO:BP	GO:0007154	cell communication	533	3983	2.17e-12
GO:BP	GO:0050896	response to stimulus	680	5379	3.74e-12
GO:BP	GO:0072359	circulatory system development	161	864	4.11e-12
GO:BP	GO:0048731	system development	389	2719	5.72e-12
GO:BP	GO:0007275	multicellular organism development	440	3170	5.72e-12
GO:BP	GO:0023052	signaling	523	3918	5.72e-12
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	156	837	8.14e-12
GO:BP	GO:0050789	regulation of biological process	891	7516	9.21e-12
GO:BP	GO:0003013	circulatory system process	96	426	1.43e-11
GO:BP	GO:0008015	blood circulation	85	357	1.64e-11
GO:BP	GO:0065007	biological regulation	908	7734	5.15e-11
GO:BP	GO:0003008	system process	193	1139	5.57e-11
GO:BP	GO:0007165	signal transduction	483	3611	6.96e-11
GO:BP	GO:0030029	actin filament-based process	125	640	9.97e-11
GO:BP	GO:0050793	regulation of developmental process	260	1697	2.48e-10
GO:BP	GO:0061061	muscle structure development	109	536	2.48e-10
GO:BP	GO:0048468	cell development	282	1886	3.66e-10
GO:BP	GO:0060047	heart contraction	54	194	9.51e-10
GO:BP	GO:0051716	cellular response to stimulus	587	4640	1.20e-09
GO:BP	GO:0050794	regulation of cellular process	842	7153	2.34e-09
GO:BP	GO:0048518	positive regulation of biological process	547	4301	5.59e-09
GO:BP	GO:0003015	heart process	54	204	6.73e-09
GO:BP	GO:0009888	tissue development	211	1348	6.73e-09
GO:BP	GO:0009719	response to endogenous stimulus	192	1197	7.02e-09
GO:BP	GO:0048522	positive regulation of cellular process	508	3954	9.71e-09
GO:BP	GO:0048519	negative regulation of biological process	487	3764	1.11e-08
GO:BP	GO:0071495	cellular response to endogenous stimulus	170	1035	1.58e-08
GO:BP	GO:0008016	regulation of heart contraction	46	165	2.64e-08
GO:BP	GO:0016477	cell migration	165	1011	4.95e-08
GO:BP	GO:0030036	actin cytoskeleton organization	106	566	5.58e-08
GO:BP	GO:0003012	muscle system process	71	325	6.70e-08
GO:BP	GO:0035239	tube morphogenesis	115	638	9.94e-08
GO:BP	GO:0040011	locomotion	137	805	1.11e-07
GO:BP	GO:0042692	muscle cell differentiation	70	323	1.17e-07
GO:BP	GO:2000145	regulation of cell motility	123	700	1.17e-07
GO:BP	GO:0048523	negative regulation of cellular process	457	3550	1.22e-07
GO:BP	GO:0044057	regulation of system process	79	384	1.22e-07
GO:BP	GO:0007166	cell surface receptor signaling pathway	259	1801	1.39e-07
GO:BP	GO:0008285	negative regulation of cell population proliferation	91	469	1.39e-07
GO:BP	GO:0035295	tube development	134	787	1.44e-07
GO:BP	GO:0055001	muscle cell development	44	163	1.50e-07
GO:BP	GO:0040012	regulation of locomotion	125	720	1.56e-07
GO:BP	GO:0030334	regulation of cell migration	118	668	1.62e-07
GO:BP	GO:1903522	regulation of blood circulation	49	194	1.90e-07
GO:BP	GO:0051146	striated muscle cell differentiation	55	234	3.18e-07
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	109	609	3.24e-07
GO:BP	GO:0048514	blood vessel morphogenesis	87	450	3.38e-07
GO:BP	GO:0030048	actin filament-based movement	33	107	4.41e-07
GO:BP	GO:0008283	cell population proliferation	197	1306	4.49e-07
GO:BP	GO:0001568	blood vessel development	97	525	4.54e-07
GO:BP	GO:0048870	cell motility	174	1120	4.71e-07
GO:BP	GO:0070252	actin-mediated cell contraction	29	87	5.05e-07
GO:BP	GO:0048513	animal organ development	279	2004	5.79e-07
GO:BP	GO:0007507	heart development	93	499	5.79e-07
GO:BP	GO:0001944	vasculature development	100	552	6.93e-07
GO:BP	GO:0051240	positive regulation of multicellular organismal process	163	1040	7.78e-07
GO:BP	GO:0060048	cardiac muscle contraction	34	116	9.47e-07
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	121	717	1.26e-06
GO:BP	GO:0009887	animal organ morphogenesis	115	673	1.45e-06
GO:BP	GO:0060537	muscle tissue development	69	339	1.53e-06
GO:BP	GO:0051093	negative regulation of developmental process	108	622	1.68e-06
GO:BP	GO:0042127	regulation of cell population proliferation	166	1077	1.71e-06
GO:BP	GO:0007155	cell adhesion	149	941	1.73e-06
GO:BP	GO:2000026	regulation of multicellular organismal development	150	951	1.98e-06
GO:BP	GO:0045595	regulation of cell differentiation	165	1073	2.15e-06
GO:BP	GO:0006936	muscle contraction	56	255	2.18e-06
GO:BP	GO:0048583	regulation of response to stimulus	356	2717	2.43e-06
GO:BP	GO:0030155	regulation of cell adhesion	92	508	2.45e-06
GO:BP	GO:0001667	ameboidal-type cell migration	69	344	2.50e-06
GO:BP	GO:0000902	cell morphogenesis	119	713	2.72e-06
GO:BP	GO:0014706	striated muscle tissue development	49	213	3.34e-06
GO:BP	GO:0048738	cardiac muscle tissue development	47	201	3.68e-06
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	54	248	4.82e-06
GO:BP	GO:0051241	negative regulation of multicellular organismal process	116	706	9.39e-06
GO:BP	GO:0006941	striated muscle contraction	37	146	1.14e-05
GO:BP	GO:0097435	supramolecular fiber organization	106	633	1.29e-05
GO:BP	GO:0023051	regulation of signaling	320	2438	1.32e-05
GO:BP	GO:0001525	angiogenesis	72	381	1.38e-05
GO:BP	GO:0065009	regulation of molecular function	188	1299	1.64e-05
GO:BP	GO:0010646	regulation of cell communication	320	2444	1.64e-05
GO:BP	GO:0003007	heart morphogenesis	48	218	1.70e-05
GO:BP	GO:0090130	tissue migration	52	247	2.38e-05
GO:BP	GO:0070848	response to growth factor	93	547	3.56e-05
GO:BP	GO:0002027	regulation of heart rate	25	83	3.56e-05
GO:BP	GO:0098657	import into cell	102	622	5.64e-05
GO:BP	GO:0061337	cardiac conduction	25	85	5.74e-05
GO:BP	GO:0065008	regulation of biological quality	254	1893	6.06e-05
GO:BP	GO:0071417	cellular response to organonitrogen compound	78	442	6.81e-05
GO:BP	GO:0009605	response to external stimulus	215	1559	7.27e-05
GO:BP	GO:0090132	epithelium migration	50	243	7.54e-05
GO:BP	GO:0010631	epithelial cell migration	50	243	7.54e-05
GO:BP	GO:0032989	cellular anatomical entity morphogenesis	97	588	7.57e-05
GO:BP	GO:0031032	actomyosin structure organization	41	184	8.32e-05
GO:BP	GO:0071363	cellular response to growth factor stimulus	89	528	8.37e-05
GO:BP	GO:0051094	positive regulation of developmental process	137	913	1.13e-04
GO:BP	GO:1901699	cellular response to nitrogen compound	82	479	1.17e-04
GO:BP	GO:0048568	embryonic organ development	58	303	1.20e-04
GO:BP	GO:0042221	response to chemical	298	2304	1.33e-04
GO:BP	GO:0010632	regulation of epithelial cell migration	41	188	1.41e-04
GO:BP	GO:0045596	negative regulation of cell differentiation	78	452	1.48e-04
GO:BP	GO:0009966	regulation of signal transduction	282	2166	1.54e-04
GO:BP	GO:0010243	response to organonitrogen compound	108	685	1.54e-04
GO:BP	GO:0071526	semaphorin-plexin signaling pathway	16	43	1.64e-04
GO:BP	GO:0003205	cardiac chamber development	35	151	1.76e-04
GO:BP	GO:0031325	positive regulation of cellular metabolic process	300	2333	1.91e-04
GO:BP	GO:0003231	cardiac ventricle development	29	115	2.10e-04
GO:BP	GO:0009628	response to abiotic stimulus	123	811	2.13e-04
GO:BP	GO:0007517	muscle organ development	52	267	2.20e-04
GO:BP	GO:0071310	cellular response to organic substance	181	1297	2.45e-04
GO:BP	GO:0003206	cardiac chamber morphogenesis	28	110	2.45e-04
GO:BP	GO:0035556	intracellular signal transduction	256	1951	2.67e-04
GO:BP	GO:0048729	tissue morphogenesis	77	453	2.78e-04
GO:BP	GO:2000147	positive regulation of cell motility	71	408	2.81e-04
GO:BP	GO:1902893	regulation of miRNA transcription	19	60	2.85e-04
GO:BP	GO:0070887	cellular response to chemical stimulus	233	1751	2.86e-04
GO:BP	GO:0040017	positive regulation of locomotion	72	416	2.87e-04
GO:BP	GO:0030239	myofibril assembly	20	66	3.35e-04
GO:BP	GO:0061614	miRNA transcription	19	61	3.63e-04
GO:BP	GO:0007010	cytoskeleton organization	162	1146	3.76e-04
GO:BP	GO:0014888	striated muscle adaptation	15	41	3.76e-04
GO:BP	GO:0090257	regulation of muscle system process	38	177	4.07e-04
GO:BP	GO:0045597	positive regulation of cell differentiation	94	591	4.20e-04
GO:BP	GO:0009893	positive regulation of metabolic process	329	2622	4.43e-04
GO:BP	GO:1901698	response to nitrogen compound	112	736	4.49e-04
GO:BP	GO:0141124	intracellular signaling cassette	181	1314	4.90e-04
GO:BP	GO:0055002	striated muscle cell development	20	68	5.16e-04
GO:BP	GO:0030335	positive regulation of cell migration	68	395	5.83e-04
GO:BP	GO:0045765	regulation of angiogenesis	40	194	6.23e-04
GO:BP	GO:0086003	cardiac muscle cell contraction	19	64	7.16e-04
GO:BP	GO:0048644	muscle organ morphogenesis	19	64	7.16e-04
GO:BP	GO:0070482	response to oxygen levels	50	265	7.16e-04
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	107	704	7.20e-04
GO:BP	GO:0010720	positive regulation of cell development	56	309	7.42e-04
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	304	2415	8.12e-04
GO:BP	GO:1901342	regulation of vasculature development	40	198	9.82e-04
GO:BP	GO:1901700	response to oxygen-containing compound	153	1093	1.06e-03
GO:BP	GO:0043500	muscle adaptation	23	89	1.10e-03
GO:BP	GO:0006915	apoptotic process	186	1377	1.10e-03
GO:BP	GO:0006937	regulation of muscle contraction	29	126	1.10e-03
GO:BP	GO:2000628	regulation of miRNA metabolic process	20	72	1.19e-03
GO:BP	GO:0060415	muscle tissue morphogenesis	18	61	1.23e-03
GO:BP	GO:0022008	neurogenesis	171	1251	1.24e-03
GO:BP	GO:0007264	small GTPase-mediated signal transduction	66	390	1.24e-03
GO:BP	GO:0040013	negative regulation of locomotion	46	243	1.30e-03
GO:BP	GO:0003018	vascular process in circulatory system	39	194	1.31e-03
GO:BP	GO:0048589	developmental growth	80	501	1.50e-03
GO:BP	GO:0010033	response to organic substance	226	1736	1.50e-03
GO:BP	GO:0014902	myotube differentiation	22	85	1.51e-03
GO:BP	GO:0071260	cellular response to mechanical stimulus	17	57	1.68e-03
GO:BP	GO:0009891	positive regulation of biosynthetic process	239	1856	1.76e-03
GO:BP	GO:0007015	actin filament organization	61	357	1.77e-03
GO:BP	GO:0086001	cardiac muscle cell action potential	18	63	1.86e-03
GO:BP	GO:1901701	cellular response to oxygen-containing compound	116	796	1.86e-03
GO:BP	GO:1902894	negative regulation of miRNA transcription	10	23	1.89e-03
GO:BP	GO:0042092	type 2 immune response	9	19	2.02e-03
GO:BP	GO:0014074	response to purine-containing compound	25	106	2.31e-03
GO:BP	GO:0008360	regulation of cell shape	25	106	2.31e-03
GO:BP	GO:0051254	positive regulation of RNA metabolic process	181	1354	2.33e-03
GO:BP	GO:0022604	regulation of cell morphogenesis	38	193	2.44e-03
GO:BP	GO:0036293	response to decreased oxygen levels	45	243	2.51e-03
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	236	1841	2.52e-03
GO:BP	GO:0012501	programmed cell death	188	1419	2.69e-03
GO:BP	GO:0009790	embryo development	118	821	2.76e-03
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	212	1633	2.99e-03
GO:BP	GO:0034330	cell junction organization	84	545	3.09e-03
GO:BP	GO:0008219	cell death	188	1423	3.09e-03
GO:BP	GO:0009725	response to hormone	92	610	3.16e-03
GO:BP	GO:0086005	ventricular cardiac muscle cell action potential	11	29	3.26e-03
GO:BP	GO:0016525	negative regulation of angiogenesis	18	66	3.30e-03
GO:BP	GO:0001666	response to hypoxia	43	232	3.37e-03
GO:BP	GO:0035272	exocrine system development	12	34	3.45e-03
GO:BP	GO:0048585	negative regulation of response to stimulus	161	1193	3.63e-03
GO:BP	GO:0051128	regulation of cellular component organization	237	1862	3.63e-03
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	229	1791	3.67e-03
GO:BP	GO:0048598	embryonic morphogenesis	68	422	3.73e-03
GO:BP	GO:0032879	regulation of localization	189	1439	3.87e-03
GO:BP	GO:2000629	negative regulation of miRNA metabolic process	10	25	3.87e-03
GO:BP	GO:1901343	negative regulation of vasculature development	18	67	3.87e-03
GO:BP	GO:2000181	negative regulation of blood vessel morphogenesis	18	67	3.87e-03
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	135	973	3.94e-03
GO:BP	GO:0051253	negative regulation of RNA metabolic process	146	1067	3.95e-03
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	165	1231	3.96e-03
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	134	965	3.96e-03
GO:BP	GO:0048699	generation of neurons	147	1076	3.96e-03
GO:BP	GO:0051960	regulation of nervous system development	57	339	4.09e-03
GO:BP	GO:0007162	negative regulation of cell adhesion	36	185	4.21e-03
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	72	456	4.22e-03
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	165	1234	4.34e-03
GO:BP	GO:0086091	regulation of heart rate by cardiac conduction	12	35	4.34e-03
GO:BP	GO:0032870	cellular response to hormone stimulus	69	433	4.34e-03
GO:BP	GO:0023057	negative regulation of signaling	142	1036	4.34e-03
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	156	1157	4.46e-03
GO:BP	GO:0060284	regulation of cell development	86	570	4.67e-03
GO:BP	GO:0051049	regulation of transport	149	1098	4.67e-03
GO:BP	GO:0007399	nervous system development	226	1775	4.81e-03
GO:BP	GO:0007267	cell-cell signaling	147	1082	4.88e-03
GO:BP	GO:0032944	regulation of mononuclear cell proliferation	26	119	5.19e-03
GO:BP	GO:0006942	regulation of striated muscle contraction	20	81	5.26e-03
GO:BP	GO:0030001	metal ion transport	80	524	5.27e-03
GO:BP	GO:0090288	negative regulation of cellular response to growth factor stimulus	19	75	5.28e-03
GO:BP	GO:0050767	regulation of neurogenesis	50	290	5.28e-03
GO:BP	GO:0034762	regulation of transmembrane transport	51	298	5.43e-03
GO:BP	GO:0071496	cellular response to external stimulus	47	268	5.43e-03
GO:BP	GO:0043542	endothelial cell migration	34	174	5.43e-03
GO:BP	GO:0010648	negative regulation of cell communication	141	1034	5.43e-03
GO:BP	GO:0038084	vascular endothelial growth factor signaling pathway	12	36	5.43e-03
GO:BP	GO:0040007	growth	101	697	5.54e-03
GO:BP	GO:0010927	cellular component assembly involved in morphogenesis	24	107	5.74e-03
GO:BP	GO:0098915	membrane repolarization during ventricular cardiac muscle cell action potential	6	10	5.82e-03
GO:BP	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	6	10	5.82e-03
GO:BP	GO:0036363	transforming growth factor beta activation	6	10	5.82e-03
GO:BP	GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance	6	10	5.82e-03
GO:BP	GO:0045064	T-helper 2 cell differentiation	6	10	5.82e-03
GO:BP	GO:0010634	positive regulation of epithelial cell migration	27	127	5.83e-03
GO:BP	GO:0099625	ventricular cardiac muscle cell membrane repolarization	9	22	5.97e-03
GO:BP	GO:0009892	negative regulation of metabolic process	261	2100	6.08e-03
GO:BP	GO:0032970	regulation of actin filament-based process	51	300	6.08e-03
GO:BP	GO:0044092	negative regulation of molecular function	77	504	6.28e-03
GO:BP	GO:0030182	neuron differentiation	138	1014	6.61e-03
GO:BP	GO:1990573	potassium ion import across plasma membrane	10	27	6.76e-03
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	270	2186	6.85e-03
GO:BP	GO:0048846	axon extension involved in axon guidance	11	32	6.94e-03
GO:BP	GO:1902284	neuron projection extension involved in neuron projection guidance	11	32	6.94e-03
GO:BP	GO:0098739	import across plasma membrane	26	122	7.02e-03
GO:BP	GO:0010594	regulation of endothelial cell migration	28	136	7.51e-03
GO:BP	GO:0031589	cell-substrate adhesion	45	258	7.63e-03
GO:BP	GO:0086065	cell communication involved in cardiac conduction	15	54	7.78e-03
GO:BP	GO:0006897	endocytosis	75	492	7.79e-03
GO:BP	GO:0030510	regulation of BMP signaling pathway	19	78	8.05e-03
GO:BP	GO:0070663	regulation of leukocyte proliferation	27	130	8.14e-03
GO:BP	GO:0001817	regulation of cytokine production	68	437	8.20e-03
GO:BP	GO:0030224	monocyte differentiation	9	23	8.26e-03
GO:BP	GO:0002026	regulation of the force of heart contraction	9	23	8.26e-03
GO:BP	GO:0045444	fat cell differentiation	34	179	8.34e-03
GO:BP	GO:0048588	developmental cell growth	34	179	8.34e-03
GO:BP	GO:0045668	negative regulation of osteoblast differentiation	12	38	8.48e-03
GO:BP	GO:0050790	regulation of catalytic activity	123	893	8.49e-03
GO:BP	GO:0044093	positive regulation of molecular function	110	783	8.49e-03
GO:BP	GO:0042981	regulation of apoptotic process	139	1031	8.77e-03
GO:BP	GO:0048841	regulation of axon extension involved in axon guidance	10	28	8.79e-03
GO:BP	GO:0072659	protein localization to plasma membrane	42	238	8.82e-03
GO:BP	GO:0031324	negative regulation of cellular metabolic process	241	1934	8.82e-03
GO:BP	GO:0051336	regulation of hydrolase activity	67	431	8.90e-03
GO:BP	GO:0055008	cardiac muscle tissue morphogenesis	15	55	9.02e-03
GO:BP	GO:0009968	negative regulation of signal transduction	132	972	9.02e-03
GO:BP	GO:0042592	homeostatic process	151	1137	9.32e-03
GO:BP	GO:0003151	outflow tract morphogenesis	17	67	9.32e-03
GO:BP	GO:0060976	coronary vasculature development	13	44	9.36e-03
GO:BP	GO:0086002	cardiac muscle cell action potential involved in contraction	13	44	9.36e-03
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	48	284	9.36e-03
GO:BP	GO:0050770	regulation of axonogenesis	26	125	9.36e-03
GO:BP	GO:0043501	skeletal muscle adaptation	8	19	9.36e-03
GO:BP	GO:0055010	ventricular cardiac muscle tissue morphogenesis	13	44	9.36e-03
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	38	210	9.66e-03
GO:BP	GO:0001816	cytokine production	68	441	9.72e-03
GO:BP	GO:0014733	regulation of skeletal muscle adaptation	6	11	9.75e-03
GO:BP	GO:1902307	positive regulation of sodium ion transmembrane transport	6	11	9.75e-03
GO:BP	GO:0048010	vascular endothelial growth factor receptor signaling pathway	14	50	1.01e-02
GO:BP	GO:0140747	regulation of ncRNA transcription	19	80	1.01e-02
GO:BP	GO:0002828	regulation of type 2 immune response	7	15	1.02e-02
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	41	233	1.02e-02
GO:BP	GO:0045785	positive regulation of cell adhesion	50	301	1.03e-02
GO:BP	GO:0003229	ventricular cardiac muscle tissue development	15	56	1.04e-02
GO:BP	GO:0046683	response to organophosphorus	21	93	1.04e-02
GO:BP	GO:0003208	cardiac ventricle morphogenesis	16	62	1.06e-02
GO:BP	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	9	24	1.06e-02
GO:BP	GO:0010586	miRNA metabolic process	20	87	1.10e-02
GO:BP	GO:0007009	plasma membrane organization	23	107	1.18e-02
GO:BP	GO:0014896	muscle hypertrophy	18	75	1.21e-02
GO:BP	GO:0002376	immune system process	181	1410	1.23e-02
GO:BP	GO:0048638	regulation of developmental growth	42	243	1.24e-02
GO:BP	GO:0002286	T cell activation involved in immune response	15	57	1.24e-02
GO:BP	GO:0016049	cell growth	60	382	1.24e-02
GO:BP	GO:0050873	brown fat cell differentiation	12	40	1.25e-02
GO:BP	GO:0043067	regulation of programmed cell death	141	1060	1.25e-02
GO:BP	GO:0071214	cellular response to abiotic stimulus	43	251	1.27e-02
GO:BP	GO:0104004	cellular response to environmental stimulus	43	251	1.27e-02
GO:BP	GO:2000651	positive regulation of sodium ion transmembrane transporter activity	5	8	1.30e-02
GO:BP	GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	44	259	1.31e-02
GO:BP	GO:0006935	chemotaxis	42	244	1.31e-02
GO:BP	GO:0043269	regulation of monoatomic ion transport	47	282	1.31e-02
GO:BP	GO:0042330	taxis	42	244	1.31e-02
GO:BP	GO:0006468	protein phosphorylation	129	958	1.31e-02
GO:BP	GO:0035725	sodium ion transmembrane transport	21	95	1.32e-02
GO:BP	GO:1901490	regulation of lymphangiogenesis	4	5	1.33e-02
GO:BP	GO:0009987	cellular process	1129	10686	1.35e-02
GO:BP	GO:0060485	mesenchyme development	42	245	1.38e-02
GO:BP	GO:0099587	inorganic ion import across plasma membrane	17	70	1.38e-02
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	38	215	1.38e-02
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	119	874	1.38e-02
GO:BP	GO:0098659	inorganic cation import across plasma membrane	17	70	1.38e-02
GO:BP	GO:0003279	cardiac septum development	22	102	1.38e-02
GO:BP	GO:0045321	leukocyte activation	78	530	1.39e-02
GO:BP	GO:0030198	extracellular matrix organization	39	223	1.42e-02
GO:BP	GO:0048858	cell projection morphogenesis	74	498	1.44e-02
GO:BP	GO:0001843	neural tube closure	19	83	1.45e-02
GO:BP	GO:0050670	regulation of lymphocyte proliferation	24	116	1.45e-02
GO:BP	GO:0071375	cellular response to peptide hormone stimulus	40	231	1.47e-02
GO:BP	GO:0045165	cell fate commitment	29	151	1.51e-02
GO:BP	GO:0043062	extracellular structure organization	39	224	1.52e-02
GO:BP	GO:0045229	external encapsulating structure organization	39	224	1.52e-02
GO:BP	GO:0060419	heart growth	17	71	1.56e-02
GO:BP	GO:0071407	cellular response to organic cyclic compound	59	379	1.56e-02
GO:BP	GO:1903038	negative regulation of leukocyte cell-cell adhesion	17	71	1.56e-02
GO:BP	GO:0090066	regulation of anatomical structure size	59	379	1.56e-02
GO:BP	GO:2000146	negative regulation of cell motility	38	217	1.56e-02
GO:BP	GO:0070664	negative regulation of leukocyte proliferation	13	47	1.56e-02
GO:BP	GO:0048662	negative regulation of smooth muscle cell proliferation	11	36	1.61e-02
GO:BP	GO:0055117	regulation of cardiac muscle contraction	16	65	1.61e-02
GO:BP	GO:0035148	tube formation	25	124	1.62e-02
GO:BP	GO:0061564	axon development	58	372	1.62e-02
GO:BP	GO:0060606	tube closure	19	84	1.62e-02
GO:BP	GO:0014912	negative regulation of smooth muscle cell migration	8	21	1.70e-02
GO:BP	GO:0048584	positive regulation of response to stimulus	190	1504	1.71e-02
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	73	494	1.72e-02
GO:BP	GO:0040008	regulation of growth	69	462	1.76e-02
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	191	1514	1.76e-02
GO:BP	GO:0031333	negative regulation of protein-containing complex assembly	24	118	1.76e-02
GO:BP	GO:0035051	cardiocyte differentiation	26	132	1.78e-02
GO:BP	GO:0010721	negative regulation of cell development	33	182	1.78e-02
GO:BP	GO:0071559	response to transforming growth factor beta	38	219	1.78e-02
GO:BP	GO:0014812	muscle cell migration	17	72	1.78e-02
GO:BP	GO:0002040	sprouting angiogenesis	21	98	1.79e-02
GO:BP	GO:0001819	positive regulation of cytokine production	43	257	1.80e-02
GO:BP	GO:0001570	vasculogenesis	16	66	1.83e-02
GO:BP	GO:0035710	CD4-positive, alpha-beta T cell activation	16	66	1.83e-02
GO:BP	GO:0051058	negative regulation of small GTPase mediated signal transduction	13	48	1.83e-02
GO:BP	GO:0055007	cardiac muscle cell differentiation	22	105	1.84e-02
GO:BP	GO:0035924	cellular response to vascular endothelial growth factor stimulus	14	54	1.85e-02
GO:BP	GO:0046323	glucose import	14	54	1.85e-02
GO:BP	GO:0060560	developmental growth involved in morphogenesis	34	190	1.85e-02
GO:BP	GO:0032869	cellular response to insulin stimulus	30	161	1.86e-02
GO:BP	GO:1902305	regulation of sodium ion transmembrane transport	11	37	1.93e-02
GO:BP	GO:0021915	neural tube development	26	133	1.93e-02
GO:BP	GO:0003300	cardiac muscle hypertrophy	17	73	2.00e-02
GO:BP	GO:0030903	notochord development	7	17	2.00e-02
GO:BP	GO:0010954	positive regulation of protein processing	7	17	2.00e-02
GO:BP	GO:0010810	regulation of cell-substrate adhesion	30	162	2.03e-02
GO:BP	GO:0042129	regulation of T cell proliferation	19	86	2.03e-02
GO:BP	GO:0014070	response to organic cyclic compound	86	606	2.03e-02
GO:BP	GO:0007409	axonogenesis	53	337	2.03e-02
GO:BP	GO:0002293	alpha-beta T cell differentiation involved in immune response	12	43	2.04e-02
GO:BP	GO:0002287	alpha-beta T cell activation involved in immune response	12	43	2.04e-02
GO:BP	GO:0042093	T-helper cell differentiation	12	43	2.04e-02
GO:BP	GO:0043086	negative regulation of catalytic activity	48	298	2.04e-02
GO:BP	GO:0045214	sarcomere organization	12	43	2.04e-02
GO:BP	GO:0002294	CD4-positive, alpha-beta T cell differentiation involved in immune response	12	43	2.04e-02
GO:BP	GO:0060411	cardiac septum morphogenesis	16	67	2.04e-02
GO:BP	GO:0071805	potassium ion transmembrane transport	24	120	2.06e-02
GO:BP	GO:0043434	response to peptide hormone	50	314	2.07e-02
GO:BP	GO:0035265	organ growth	25	127	2.07e-02
GO:BP	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	5	9	2.12e-02
GO:BP	GO:0007405	neuroblast proliferation	14	55	2.12e-02
GO:BP	GO:1901388	regulation of transforming growth factor beta activation	5	9	2.12e-02
GO:BP	GO:0032673	regulation of interleukin-4 production	6	13	2.19e-02
GO:BP	GO:1903729	regulation of plasma membrane organization	6	13	2.19e-02
GO:BP	GO:0032633	interleukin-4 production	6	13	2.19e-02
GO:BP	GO:0048666	neuron development	113	838	2.21e-02
GO:BP	GO:0014897	striated muscle hypertrophy	17	74	2.22e-02
GO:BP	GO:0014020	primary neural tube formation	19	87	2.22e-02
GO:BP	GO:0006811	monoatomic ion transport	99	719	2.24e-02
GO:BP	GO:1901491	negative regulation of lymphangiogenesis	3	3	2.24e-02
GO:BP	GO:0086047	membrane depolarization during Purkinje myocyte cell action potential	3	3	2.24e-02
GO:BP	GO:0045760	positive regulation of action potential	3	3	2.24e-02
GO:BP	GO:0007179	transforming growth factor beta receptor signaling pathway	31	171	2.24e-02
GO:BP	GO:0006949	syncytium formation	11	38	2.25e-02
GO:BP	GO:0043502	regulation of muscle adaptation	16	68	2.30e-02
GO:BP	GO:0098771	inorganic ion homeostasis	54	348	2.32e-02
GO:BP	GO:0001775	cell activation	88	627	2.32e-02
GO:BP	GO:0032943	mononuclear cell proliferation	29	157	2.34e-02
GO:BP	GO:0010959	regulation of metal ion transport	40	239	2.35e-02
GO:BP	GO:0043066	negative regulation of apoptotic process	87	619	2.35e-02
GO:BP	GO:0048878	chemical homeostasis	93	670	2.39e-02
GO:BP	GO:0097485	neuron projection guidance	31	172	2.41e-02
GO:BP	GO:0007411	axon guidance	31	172	2.41e-02
GO:BP	GO:1903708	positive regulation of hemopoiesis	23	115	2.42e-02
GO:BP	GO:1902107	positive regulation of leukocyte differentiation	23	115	2.42e-02
GO:BP	GO:0098655	monoatomic cation transmembrane transport	72	495	2.42e-02
GO:BP	GO:0061387	regulation of extent of cell growth	19	88	2.43e-02
GO:BP	GO:0046631	alpha-beta T cell activation	19	88	2.43e-02
GO:BP	GO:0150115	cell-substrate junction organization	20	95	2.54e-02
GO:BP	GO:0030336	negative regulation of cell migration	36	210	2.54e-02
GO:BP	GO:0098660	inorganic ion transmembrane transport	75	521	2.54e-02
GO:BP	GO:0044087	regulation of cellular component biogenesis	103	757	2.54e-02
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	36	210	2.54e-02
GO:BP	GO:1990778	protein localization to cell periphery	46	287	2.57e-02
GO:BP	GO:0098662	inorganic cation transmembrane transport	70	480	2.57e-02
GO:BP	GO:0003281	ventricular septum development	16	69	2.57e-02
GO:BP	GO:0001508	action potential	21	102	2.57e-02
GO:BP	GO:1903319	positive regulation of protein maturation	7	18	2.59e-02
GO:BP	GO:0006814	sodium ion transport	26	137	2.60e-02
GO:BP	GO:0032868	response to insulin	35	203	2.61e-02
GO:BP	GO:0009266	response to temperature stimulus	23	116	2.62e-02
GO:BP	GO:0006812	monoatomic cation transport	86	614	2.63e-02
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	148	1150	2.63e-02
GO:BP	GO:0003433	chondrocyte development involved in endochondral bone morphogenesis	4	6	2.66e-02
GO:BP	GO:0048843	negative regulation of axon extension involved in axon guidance	8	23	2.67e-02
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	237	1951	2.67e-02
GO:BP	GO:0006950	response to stress	301	2540	2.67e-02
GO:BP	GO:0010765	positive regulation of sodium ion transport	8	23	2.67e-02
GO:BP	GO:0009612	response to mechanical stimulus	28	152	2.71e-02
GO:BP	GO:0002573	myeloid leukocyte differentiation	28	152	2.71e-02
GO:BP	GO:0002292	T cell differentiation involved in immune response	12	45	2.72e-02
GO:BP	GO:0051346	negative regulation of hydrolase activity	23	117	2.87e-02
GO:BP	GO:0072175	epithelial tube formation	23	117	2.87e-02
GO:BP	GO:1903037	regulation of leukocyte cell-cell adhesion	34	197	2.88e-02
GO:BP	GO:0043069	negative regulation of programmed cell death	89	642	2.90e-02
GO:BP	GO:0009991	response to extracellular stimulus	57	377	2.90e-02
GO:BP	GO:0016310	phosphorylation	147	1145	2.92e-02
GO:BP	GO:0043114	regulation of vascular permeability	10	34	2.94e-02
GO:BP	GO:0070661	leukocyte proliferation	31	175	2.94e-02
GO:BP	GO:0050868	negative regulation of T cell activation	15	64	3.02e-02
GO:BP	GO:0055017	cardiac muscle tissue growth	15	64	3.02e-02
GO:BP	GO:0010885	regulation of cholesterol storage	6	14	3.03e-02
GO:BP	GO:0050996	positive regulation of lipid catabolic process	6	14	3.03e-02
GO:BP	GO:0031667	response to nutrient levels	54	354	3.06e-02
GO:BP	GO:0007163	establishment or maintenance of cell polarity	32	183	3.06e-02
GO:BP	GO:0046324	regulation of glucose import	11	40	3.11e-02
GO:BP	GO:0071773	cellular response to BMP stimulus	23	118	3.11e-02
GO:BP	GO:0002028	regulation of sodium ion transport	14	58	3.11e-02
GO:BP	GO:0071772	response to BMP	23	118	3.11e-02
GO:BP	GO:0002521	leukocyte differentiation	56	371	3.19e-02
GO:BP	GO:0001501	skeletal system development	53	347	3.21e-02
GO:BP	GO:0019222	regulation of metabolic process	518	4603	3.21e-02
GO:BP	GO:0033275	actin-myosin filament sliding	5	10	3.22e-02
GO:BP	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	5	10	3.22e-02
GO:BP	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway	5	10	3.22e-02
GO:BP	GO:0010832	negative regulation of myotube differentiation	5	10	3.22e-02
GO:BP	GO:0007160	cell-matrix adhesion	30	169	3.22e-02
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	218	1787	3.22e-02
GO:BP	GO:0045926	negative regulation of growth	32	184	3.23e-02
GO:BP	GO:0055085	transmembrane transport	121	921	3.23e-02
GO:BP	GO:0050769	positive regulation of neurogenesis	32	184	3.23e-02
GO:BP	GO:0034220	monoatomic ion transmembrane transport	82	587	3.31e-02
GO:BP	GO:0060429	epithelium development	106	792	3.31e-02
GO:BP	GO:0086010	membrane depolarization during action potential	8	24	3.31e-02
GO:BP	GO:0060562	epithelial tube morphogenesis	42	261	3.31e-02
GO:BP	GO:0014887	cardiac muscle adaptation	8	24	3.31e-02
GO:BP	GO:0071398	cellular response to fatty acid	8	24	3.31e-02
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	42	261	3.31e-02
GO:BP	GO:0014898	cardiac muscle hypertrophy in response to stress	8	24	3.31e-02
GO:BP	GO:0003299	muscle hypertrophy in response to stress	8	24	3.31e-02
GO:BP	GO:0055006	cardiac cell development	17	78	3.33e-02
GO:BP	GO:0048705	skeletal system morphogenesis	27	148	3.43e-02
GO:BP	GO:0070228	regulation of lymphocyte apoptotic process	10	35	3.46e-02
GO:BP	GO:0050994	regulation of lipid catabolic process	10	35	3.46e-02
GO:BP	GO:0060840	artery development	18	85	3.47e-02
GO:BP	GO:0048640	negative regulation of developmental growth	18	85	3.47e-02
GO:BP	GO:0006816	calcium ion transport	42	262	3.51e-02
GO:BP	GO:0006796	phosphate-containing compound metabolic process	228	1883	3.52e-02
GO:BP	GO:0001657	ureteric bud development	16	72	3.53e-02
GO:BP	GO:0022407	regulation of cell-cell adhesion	44	278	3.53e-02
GO:BP	GO:0001841	neural tube formation	19	92	3.53e-02
GO:BP	GO:0098609	cell-cell adhesion	79	564	3.53e-02
GO:BP	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	19	92	3.53e-02
GO:BP	GO:0055013	cardiac muscle cell development	16	72	3.53e-02
GO:BP	GO:1903131	mononuclear cell differentiation	44	278	3.53e-02
GO:BP	GO:0001838	embryonic epithelial tube formation	21	106	3.62e-02
GO:BP	GO:0030097	hemopoiesis	86	624	3.64e-02
GO:BP	GO:0009967	positive regulation of signal transduction	140	1093	3.68e-02
GO:BP	GO:0002761	regulation of myeloid leukocyte differentiation	17	79	3.70e-02
GO:BP	GO:0006793	phosphorus metabolic process	230	1904	3.70e-02
GO:BP	GO:0018212	peptidyl-tyrosine modification	29	164	3.74e-02
GO:BP	GO:0010647	positive regulation of cell communication	154	1218	3.75e-02
GO:BP	GO:0043254	regulation of protein-containing complex assembly	50	327	3.80e-02
GO:BP	GO:0014904	myotube cell development	9	30	3.80e-02
GO:BP	GO:0006813	potassium ion transport	25	135	3.81e-02
GO:BP	GO:0014909	smooth muscle cell migration	14	60	3.94e-02
GO:BP	GO:0072164	mesonephric tubule development	16	73	3.97e-02
GO:BP	GO:0072163	mesonephric epithelium development	16	73	3.97e-02
GO:BP	GO:0007159	leukocyte cell-cell adhesion	36	218	4.06e-02
GO:BP	GO:0023056	positive regulation of signaling	154	1221	4.07e-02
GO:BP	GO:0071320	cellular response to cAMP	10	36	4.09e-02
GO:BP	GO:0042475	odontogenesis of dentin-containing tooth	13	54	4.09e-02
GO:BP	GO:0085029	extracellular matrix assembly	10	36	4.09e-02
GO:BP	GO:0042130	negative regulation of T cell proliferation	10	36	4.09e-02
GO:BP	GO:0002009	morphogenesis of an epithelium	55	369	4.10e-02
GO:BP	GO:0007435	salivary gland morphogenesis	8	25	4.11e-02
GO:BP	GO:0009410	response to xenobiotic stimulus	43	273	4.13e-02
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	32	188	4.15e-02
GO:BP	GO:0010718	positive regulation of epithelial to mesenchymal transition	12	48	4.16e-02
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	63	435	4.17e-02
GO:BP	GO:0086009	membrane repolarization	11	42	4.17e-02
GO:BP	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	7	20	4.23e-02
GO:BP	GO:0046651	lymphocyte proliferation	27	151	4.23e-02
GO:BP	GO:1902547	regulation of cellular response to vascular endothelial growth factor stimulus	7	20	4.23e-02
GO:BP	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	23	122	4.23e-02
GO:BP	GO:0030308	negative regulation of cell growth	26	144	4.35e-02
GO:BP	GO:0042391	regulation of membrane potential	44	282	4.37e-02
GO:BP	GO:0001823	mesonephros development	16	74	4.41e-02
GO:BP	GO:0010644	cell communication by electrical coupling	9	31	4.51e-02
GO:BP	GO:0045657	positive regulation of monocyte differentiation	4	7	4.51e-02
GO:BP	GO:0044351	macropinocytosis	4	7	4.51e-02
GO:BP	GO:0042060	wound healing	45	291	4.51e-02
GO:BP	GO:1900373	positive regulation of purine nucleotide biosynthetic process	4	7	4.51e-02
GO:BP	GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	23	123	4.51e-02
GO:BP	GO:0010830	regulation of myotube differentiation	9	31	4.51e-02
GO:BP	GO:1903351	cellular response to dopamine	9	31	4.51e-02
GO:BP	GO:0002830	positive regulation of type 2 immune response	4	7	4.51e-02
GO:BP	GO:0032753	positive regulation of interleukin-4 production	4	7	4.51e-02
GO:BP	GO:0001558	regulation of cell growth	49	323	4.51e-02
GO:BP	GO:0014883	transition between fast and slow fiber	4	7	4.51e-02
GO:BP	GO:0048812	neuron projection morphogenesis	68	479	4.51e-02
GO:BP	GO:0010975	regulation of neuron projection development	53	355	4.51e-02
GO:BP	GO:0070296	sarcoplasmic reticulum calcium ion transport	9	31	4.51e-02
GO:BP	GO:0045628	regulation of T-helper 2 cell differentiation	4	7	4.51e-02
GO:BP	GO:0030810	positive regulation of nucleotide biosynthetic process	4	7	4.51e-02
GO:BP	GO:0071634	regulation of transforming growth factor beta production	9	31	4.51e-02
GO:BP	GO:0008150	biological_process	1175	11244	4.51e-02
GO:BP	GO:0099622	cardiac muscle cell membrane repolarization	9	31	4.51e-02
GO:BP	GO:0030030	cell projection organization	149	1182	4.51e-02
GO:BP	GO:0090189	regulation of branching involved in ureteric bud morphogenesis	5	11	4.52e-02
GO:BP	GO:0021783	preganglionic parasympathetic fiber development	5	11	4.52e-02
GO:BP	GO:0007044	cell-substrate junction assembly	18	88	4.53e-02
GO:BP	GO:0031175	neuron projection development	99	743	4.54e-02
GO:BP	GO:0150104	transport across blood-brain barrier	15	68	4.56e-02
GO:BP	GO:0009894	regulation of catabolic process	109	830	4.56e-02
GO:BP	GO:0010232	vascular transport	15	68	4.56e-02
GO:BP	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	25	138	4.67e-02
GO:BP	GO:0050672	negative regulation of lymphocyte proliferation	11	43	4.72e-02
GO:BP	GO:0032945	negative regulation of mononuclear cell proliferation	11	43	4.72e-02
GO:BP	GO:0051591	response to cAMP	14	62	4.90e-02
GO:BP	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	8	26	4.94e-02
GO:BP	GO:0007431	salivary gland development	8	26	4.94e-02
GO:BP	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	8	26	4.94e-02
GO:BP	GO:0031323	regulation of cellular metabolic process	476	4233	4.98e-02

ESRnomtable_20k_enh %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in ESR enhancer neargenes_20k") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in ESR enhancer neargenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:04261	Adrenergic signaling in cardiomyocytes	37	124	3.15e-07
KEGG	KEGG:04022	cGMP-PKG signaling pathway	37	129	5.30e-07
KEGG	KEGG:04925	Aldosterone synthesis and secretion	25	75	4.82e-06
KEGG	KEGG:05414	Dilated cardiomyopathy	26	82	6.21e-06
KEGG	KEGG:05200	Pathways in cancer	73	391	1.30e-05
KEGG	KEGG:04024	cAMP signaling pathway	35	147	6.89e-05
KEGG	KEGG:05410	Hypertrophic cardiomyopathy	22	77	2.45e-04
KEGG	KEGG:04976	Bile secretion	15	41	2.45e-04
KEGG	KEGG:04931	Insulin resistance	24	91	3.33e-04
KEGG	KEGG:04921	Oxytocin signaling pathway	27	113	6.15e-04
KEGG	KEGG:04020	Calcium signaling pathway	34	161	7.81e-04
KEGG	KEGG:04360	Axon guidance	33	155	7.81e-04
KEGG	KEGG:04927	Cortisol synthesis and secretion	15	46	7.81e-04
KEGG	KEGG:04725	Cholinergic synapse	21	82	1.14e-03
KEGG	KEGG:04926	Relaxin signaling pathway	24	100	1.14e-03
KEGG	KEGG:05203	Viral carcinogenesis	30	142	1.66e-03
KEGG	KEGG:05166	Human T-cell leukemia virus 1 infection	33	164	1.93e-03
KEGG	KEGG:04911	Insulin secretion	17	62	1.94e-03
KEGG	KEGG:04971	Gastric acid secretion	15	51	1.95e-03
KEGG	KEGG:04928	Parathyroid hormone synthesis, secretion and action	19	78	3.91e-03
KEGG	KEGG:04934	Cushing syndrome	25	119	5.26e-03
KEGG	KEGG:04933	AGE-RAGE signaling pathway in diabetic complications	20	87	5.63e-03
KEGG	KEGG:04015	Rap1 signaling pathway	31	162	5.79e-03
KEGG	KEGG:04260	Cardiac muscle contraction	16	63	5.98e-03
KEGG	KEGG:04740	Olfactory transduction	9	25	6.49e-03
KEGG	KEGG:04014	Ras signaling pathway	31	164	6.49e-03
KEGG	KEGG:03320	PPAR signaling pathway	13	47	7.20e-03
KEGG	KEGG:04915	Estrogen signaling pathway	20	90	7.20e-03
KEGG	KEGG:04371	Apelin signaling pathway	22	104	7.64e-03
KEGG	KEGG:05163	Human cytomegalovirus infection	30	160	7.77e-03
KEGG	KEGG:04066	HIF-1 signaling pathway	19	86	9.32e-03
KEGG	KEGG:05030	Cocaine addiction	10	32	9.39e-03
KEGG	KEGG:04713	Circadian entrainment	16	68	1.07e-02
KEGG	KEGG:04520	Adherens junction	18	83	1.44e-02
KEGG	KEGG:04728	Dopaminergic synapse	20	97	1.51e-02
KEGG	KEGG:04922	Glucagon signaling pathway	17	78	1.71e-02
KEGG	KEGG:04923	Regulation of lipolysis in adipocytes	11	41	1.75e-02
KEGG	KEGG:04814	Motor proteins	26	141	1.75e-02
KEGG	KEGG:04380	Osteoclast differentiation	19	92	1.75e-02
KEGG	KEGG:00000	KEGG root term	604	5451	1.96e-02
KEGG	KEGG:04151	PI3K-Akt signaling pathway	40	250	2.10e-02
KEGG	KEGG:04916	Melanogenesis	16	75	2.48e-02
KEGG	KEGG:04913	Ovarian steroidogenesis	8	26	2.51e-02
KEGG	KEGG:04935	Growth hormone synthesis, secretion and action	19	96	2.53e-02
KEGG	KEGG:04670	Leukocyte transendothelial migration	16	76	2.66e-02
KEGG	KEGG:04310	Wnt signaling pathway	24	133	2.76e-02
KEGG	KEGG:04919	Thyroid hormone signaling pathway	20	105	2.98e-02
KEGG	KEGG:05031	Amphetamine addiction	11	45	3.12e-02
KEGG	KEGG:04910	Insulin signaling pathway	21	113	3.13e-02
KEGG	KEGG:04750	Inflammatory mediator regulation of TRP channels	15	72	3.48e-02
KEGG	KEGG:05206	MicroRNAs in cancer	25	144	3.51e-02
KEGG	KEGG:04961	Endocrine and other factor-regulated calcium reabsorption	10	40	3.57e-02
KEGG	KEGG:04659	Th17 cell differentiation	13	60	4.01e-02
KEGG	KEGG:05034	Alcoholism	19	102	4.02e-02
KEGG	KEGG:04510	Focal adhesion	28	169	4.02e-02
KEGG	KEGG:04970	Salivary secretion	12	54	4.08e-02
KEGG	KEGG:05032	Morphine addiction	12	54	4.08e-02
KEGG	KEGG:05211	Renal cell carcinoma	13	62	4.79e-02
KEGG	KEGG:05146	Amoebiasis	13	62	4.79e-02
KEGG	KEGG:04721	Synaptic vesicle cycle	11	49	4.91e-02

LR 20,000 bp NG

# LR_resgenes_20k <- gost(query = LR_peak_list_20k$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(LR_resgenes_20k,"data/GO_KEGG_analysis/LR_resgenes_20k.RDS")


# LRnom <- gostplot(LR_resgenes_20k, capped = FALSE, interactive = TRUE)
# LRnom

LRnomtable_20k <- LR_resgenes_20k$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

LRnomtable_20k %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in LR nESRgenes_20k" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in LR nESRgenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0032501	multicellular organismal process	3247	4504	2.82e-47
GO:BP	GO:0048856	anatomical structure development	2795	3867	2.23e-39
GO:BP	GO:0048731	system development	2022	2719	3.44e-38
GO:BP	GO:0007275	multicellular organism development	2324	3170	7.17e-38
GO:BP	GO:0032502	developmental process	2991	4179	1.92e-37
GO:BP	GO:0007154	cell communication	2854	3983	1.21e-35
GO:BP	GO:0023052	signaling	2810	3918	1.94e-35
GO:BP	GO:0009653	anatomical structure morphogenesis	1401	1844	6.31e-32
GO:BP	GO:0007165	signal transduction	2587	3611	6.46e-31
GO:BP	GO:0050896	response to stimulus	3737	5379	2.12e-30
GO:BP	GO:0048869	cellular developmental process	2041	2804	6.29e-29
GO:BP	GO:0030154	cell differentiation	2040	2803	6.90e-29
GO:BP	GO:0051716	cellular response to stimulus	3243	4640	2.39e-27
GO:BP	GO:0007399	nervous system development	1335	1775	8.03e-27
GO:BP	GO:0022008	neurogenesis	963	1251	4.06e-24
GO:BP	GO:0010646	regulation of cell communication	1772	2444	9.29e-23
GO:BP	GO:0048699	generation of neurons	834	1076	3.77e-22
GO:BP	GO:0023051	regulation of signaling	1765	2438	3.77e-22
GO:BP	GO:0048513	animal organ development	1472	2004	4.86e-22
GO:BP	GO:0050793	regulation of developmental process	1263	1697	5.10e-22
GO:BP	GO:0051239	regulation of multicellular organismal process	1416	1924	1.17e-21
GO:BP	GO:0048468	cell development	1386	1886	1.13e-20
GO:BP	GO:0030182	neuron differentiation	785	1014	1.66e-20
GO:BP	GO:0007166	cell surface receptor signaling pathway	1327	1801	2.11e-20
GO:BP	GO:0050789	regulation of biological process	5035	7516	3.13e-20
GO:BP	GO:0031175	neuron projection development	592	743	3.28e-20
GO:BP	GO:0007155	cell adhesion	732	941	4.87e-20
GO:BP	GO:0048583	regulation of response to stimulus	1940	2717	5.30e-20
GO:BP	GO:0048666	neuron development	656	838	5.56e-19
GO:BP	GO:0000902	cell morphogenesis	567	713	5.79e-19
GO:BP	GO:0065007	biological regulation	5159	7734	2.58e-18
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	872	1150	2.65e-18
GO:BP	GO:0030030	cell projection organization	894	1182	2.85e-18
GO:BP	GO:0003008	system process	864	1139	3.17e-18
GO:BP	GO:0032989	cellular anatomical entity morphogenesis	475	588	3.28e-18
GO:BP	GO:0050794	regulation of cellular process	4791	7153	6.38e-18
GO:BP	GO:0009966	regulation of signal transduction	1557	2166	4.58e-17
GO:BP	GO:0016477	cell migration	770	1011	7.96e-17
GO:BP	GO:0048858	cell projection morphogenesis	406	498	9.87e-17
GO:BP	GO:0048812	neuron projection morphogenesis	392	479	1.11e-16
GO:BP	GO:0048518	positive regulation of biological process	2959	4301	1.11e-16
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	402	494	2.61e-16
GO:BP	GO:0048870	cell motility	843	1120	3.51e-16
GO:BP	GO:0048522	positive regulation of cellular process	2728	3954	7.52e-16
GO:BP	GO:0007267	cell-cell signaling	815	1082	9.81e-16
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	357	435	1.66e-15
GO:BP	GO:0065008	regulation of biological quality	1364	1893	3.54e-15
GO:BP	GO:0009888	tissue development	993	1348	1.17e-14
GO:BP	GO:0141124	intracellular signaling cassette	969	1314	1.78e-14
GO:BP	GO:0034330	cell junction organization	433	545	3.80e-14
GO:BP	GO:0051094	positive regulation of developmental process	691	913	6.65e-14
GO:BP	GO:0040012	regulation of locomotion	556	720	8.00e-14
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	403	505	1.10e-13
GO:BP	GO:0040011	locomotion	615	805	1.10e-13
GO:BP	GO:0072359	circulatory system development	656	864	1.12e-13
GO:BP	GO:0010975	regulation of neuron projection development	294	355	1.12e-13
GO:BP	GO:2000145	regulation of cell motility	541	700	1.42e-13
GO:BP	GO:0031344	regulation of cell projection organization	409	516	4.84e-13
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	551	717	5.29e-13
GO:BP	GO:0009887	animal organ morphogenesis	520	673	5.64e-13
GO:BP	GO:0061564	axon development	304	372	1.22e-12
GO:BP	GO:0001568	blood vessel development	414	525	1.43e-12
GO:BP	GO:0030334	regulation of cell migration	515	668	1.53e-12
GO:BP	GO:0007409	axonogenesis	278	337	1.71e-12
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	473	609	2.07e-12
GO:BP	GO:0045595	regulation of cell differentiation	794	1073	3.38e-12
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	631	837	4.65e-12
GO:BP	GO:0051240	positive regulation of multicellular organismal process	770	1040	7.02e-12
GO:BP	GO:0098657	import into cell	480	622	9.09e-12
GO:BP	GO:2000026	regulation of multicellular organismal development	708	951	1.15e-11
GO:BP	GO:0035556	intracellular signal transduction	1383	1951	1.15e-11
GO:BP	GO:0001944	vasculature development	430	552	1.40e-11
GO:BP	GO:0051128	regulation of cellular component organization	1323	1862	1.45e-11
GO:BP	GO:0071495	cellular response to endogenous stimulus	764	1035	2.55e-11
GO:BP	GO:0035295	tube development	593	787	3.20e-11
GO:BP	GO:0003013	circulatory system process	339	426	3.72e-11
GO:BP	GO:0098609	cell-cell adhesion	437	564	3.81e-11
GO:BP	GO:0030029	actin filament-based process	490	640	4.81e-11
GO:BP	GO:0044057	regulation of system process	308	384	7.16e-11
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	197	233	1.09e-10
GO:BP	GO:0045597	positive regulation of cell differentiation	454	591	1.44e-10
GO:BP	GO:0048519	negative regulation of biological process	2565	3764	1.53e-10
GO:BP	GO:0006897	endocytosis	384	492	1.68e-10
GO:BP	GO:0035239	tube morphogenesis	486	638	2.45e-10
GO:BP	GO:0006810	transport	2054	2984	3.55e-10
GO:BP	GO:0051093	negative regulation of developmental process	474	622	4.11e-10
GO:BP	GO:0009719	response to endogenous stimulus	868	1197	4.54e-10
GO:BP	GO:0048523	negative regulation of cellular process	2422	3550	4.64e-10
GO:BP	GO:0032879	regulation of localization	1031	1439	4.65e-10
GO:BP	GO:0016043	cellular component organization	3229	4802	7.98e-10
GO:BP	GO:0051179	localization	2537	3731	9.27e-10
GO:BP	GO:0051049	regulation of transport	798	1098	1.70e-09
GO:BP	GO:0007264	small GTPase-mediated signal transduction	308	390	2.21e-09
GO:BP	GO:0048589	developmental growth	386	501	3.35e-09
GO:BP	GO:0030001	metal ion transport	402	524	3.65e-09
GO:BP	GO:0009987	cellular process	6915	10686	5.43e-09
GO:BP	GO:0048514	blood vessel morphogenesis	349	450	6.96e-09
GO:BP	GO:0030036	actin cytoskeleton organization	430	566	8.49e-09
GO:BP	GO:0023056	positive regulation of signaling	877	1221	9.65e-09
GO:BP	GO:0010647	positive regulation of cell communication	875	1218	9.65e-09
GO:BP	GO:0042221	response to chemical	1596	2304	1.28e-08
GO:BP	GO:0008015	blood circulation	282	357	1.41e-08
GO:BP	GO:0051130	positive regulation of cellular component organization	624	850	2.01e-08
GO:BP	GO:0030155	regulation of cell adhesion	388	508	2.12e-08
GO:BP	GO:0008150	biological_process	7248	11244	2.12e-08
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	351	456	3.01e-08
GO:BP	GO:0051234	establishment of localization	2205	3240	3.03e-08
GO:BP	GO:0048584	positive regulation of response to stimulus	1062	1504	5.39e-08
GO:BP	GO:0007010	cytoskeleton organization	822	1146	5.91e-08
GO:BP	GO:0097435	supramolecular fiber organization	473	633	5.91e-08
GO:BP	GO:0071417	cellular response to organonitrogen compound	340	442	6.37e-08
GO:BP	GO:0045596	negative regulation of cell differentiation	347	452	6.39e-08
GO:BP	GO:0002062	chondrocyte differentiation	81	88	7.39e-08
GO:BP	GO:0070887	cellular response to chemical stimulus	1225	1751	7.72e-08
GO:BP	GO:0034329	cell junction assembly	255	323	1.10e-07
GO:BP	GO:0016192	vesicle-mediated transport	824	1152	1.30e-07
GO:BP	GO:0007417	central nervous system development	513	694	1.59e-07
GO:BP	GO:0099537	trans-synaptic signaling	356	467	1.62e-07
GO:BP	GO:0099536	synaptic signaling	367	483	1.79e-07
GO:BP	GO:0034220	monoatomic ion transmembrane transport	439	587	1.92e-07
GO:BP	GO:0099177	regulation of trans-synaptic signaling	254	323	2.29e-07
GO:BP	GO:0006811	monoatomic ion transport	529	719	2.71e-07
GO:BP	GO:0050804	modulation of chemical synaptic transmission	253	322	2.81e-07
GO:BP	GO:0009967	positive regulation of signal transduction	782	1093	3.16e-07
GO:BP	GO:0007268	chemical synaptic transmission	352	463	3.27e-07
GO:BP	GO:0098916	anterograde trans-synaptic signaling	352	463	3.27e-07
GO:BP	GO:0098660	inorganic ion transmembrane transport	392	521	3.95e-07
GO:BP	GO:0016310	phosphorylation	816	1145	4.44e-07
GO:BP	GO:0051960	regulation of nervous system development	264	339	5.96e-07
GO:BP	GO:0071310	cellular response to organic substance	916	1297	8.30e-07
GO:BP	GO:0042391	regulation of membrane potential	223	282	8.39e-07
GO:BP	GO:2000147	positive regulation of cell motility	312	408	8.56e-07
GO:BP	GO:0050770	regulation of axonogenesis	108	125	8.81e-07
GO:BP	GO:0050808	synapse organization	262	337	8.81e-07
GO:BP	GO:0001501	skeletal system development	269	347	9.14e-07
GO:BP	GO:0001503	ossification	237	302	9.90e-07
GO:BP	GO:1902531	regulation of intracellular signal transduction	910	1289	1.00e-06
GO:BP	GO:1901699	cellular response to nitrogen compound	361	479	1.10e-06
GO:BP	GO:0070848	response to growth factor	408	547	1.11e-06
GO:BP	GO:0006812	monoatomic cation transport	454	614	1.15e-06
GO:BP	GO:0040017	positive regulation of locomotion	317	416	1.18e-06
GO:BP	GO:0061448	connective tissue development	167	205	1.18e-06
GO:BP	GO:0061061	muscle structure development	400	536	1.36e-06
GO:BP	GO:0030335	positive regulation of cell migration	302	395	1.41e-06
GO:BP	GO:0031346	positive regulation of cell projection organization	225	286	1.49e-06
GO:BP	GO:0030900	forebrain development	215	272	1.49e-06
GO:BP	GO:0001525	angiogenesis	292	381	1.57e-06
GO:BP	GO:0060627	regulation of vesicle-mediated transport	287	374	1.66e-06
GO:BP	GO:0007507	heart development	374	499	1.68e-06
GO:BP	GO:0006468	protein phosphorylation	686	958	2.16e-06
GO:BP	GO:0048771	tissue remodeling	98	113	2.51e-06
GO:BP	GO:0098662	inorganic cation transmembrane transport	360	480	2.67e-06
GO:BP	GO:0051216	cartilage development	122	145	2.67e-06
GO:BP	GO:0050767	regulation of neurogenesis	227	290	2.67e-06
GO:BP	GO:1903522	regulation of blood circulation	158	194	2.75e-06
GO:BP	GO:0071840	cellular component organization or biogenesis	3312	4988	2.76e-06
GO:BP	GO:0031589	cell-substrate adhesion	204	258	3.07e-06
GO:BP	GO:0044089	positive regulation of cellular component biogenesis	297	390	3.39e-06
GO:BP	GO:0048638	regulation of developmental growth	193	243	3.74e-06
GO:BP	GO:0060322	head development	400	539	3.74e-06
GO:BP	GO:0043087	regulation of GTPase activity	137	166	4.43e-06
GO:BP	GO:0071363	cellular response to growth factor stimulus	392	528	4.66e-06
GO:BP	GO:0016055	Wnt signaling pathway	274	358	4.90e-06
GO:BP	GO:0044087	regulation of cellular component biogenesis	548	757	5.19e-06
GO:BP	GO:0098655	monoatomic cation transmembrane transport	369	495	5.31e-06
GO:BP	GO:0010243	response to organonitrogen compound	499	685	5.42e-06
GO:BP	GO:0007015	actin filament organization	273	357	5.82e-06
GO:BP	GO:0051241	negative regulation of multicellular organismal process	513	706	6.07e-06
GO:BP	GO:0097485	neuron projection guidance	141	172	6.24e-06
GO:BP	GO:0007411	axon guidance	141	172	6.24e-06
GO:BP	GO:0060047	heart contraction	157	194	6.32e-06
GO:BP	GO:0198738	cell-cell signaling by wnt	274	359	7.32e-06
GO:BP	GO:0003015	heart process	164	204	7.73e-06
GO:BP	GO:0034762	regulation of transmembrane transport	231	298	7.99e-06
GO:BP	GO:0003012	muscle system process	250	325	8.03e-06
GO:BP	GO:0140352	export from cell	436	594	8.12e-06
GO:BP	GO:0048585	negative regulation of response to stimulus	839	1193	9.34e-06
GO:BP	GO:0044093	positive regulation of molecular function	564	783	9.57e-06
GO:BP	GO:0060429	epithelium development	570	792	9.84e-06
GO:BP	GO:0030010	establishment of cell polarity	105	124	1.05e-05
GO:BP	GO:0014706	striated muscle tissue development	170	213	1.12e-05
GO:BP	GO:0009790	embryo development	589	821	1.23e-05
GO:BP	GO:0006793	phosphorus metabolic process	1308	1904	1.24e-05
GO:BP	GO:0010720	positive regulation of cell development	238	309	1.27e-05
GO:BP	GO:0046903	secretion	454	622	1.31e-05
GO:BP	GO:0008016	regulation of heart contraction	135	165	1.34e-05
GO:BP	GO:0035265	organ growth	107	127	1.34e-05
GO:BP	GO:0030111	regulation of Wnt signaling pathway	204	261	1.34e-05
GO:BP	GO:0048639	positive regulation of developmental growth	101	119	1.36e-05
GO:BP	GO:0048729	tissue morphogenesis	338	453	1.41e-05
GO:BP	GO:1901698	response to nitrogen compound	531	736	1.50e-05
GO:BP	GO:0060284	regulation of cell development	418	570	1.64e-05
GO:BP	GO:0040007	growth	504	697	1.93e-05
GO:BP	GO:1901700	response to oxygen-containing compound	770	1093	1.93e-05
GO:BP	GO:0006796	phosphate-containing compound metabolic process	1292	1883	2.12e-05
GO:BP	GO:0090066	regulation of anatomical structure size	286	379	2.12e-05
GO:BP	GO:0045229	external encapsulating structure organization	177	224	2.12e-05
GO:BP	GO:0043062	extracellular structure organization	177	224	2.12e-05
GO:BP	GO:0032409	regulation of transporter activity	122	148	2.19e-05
GO:BP	GO:0007420	brain development	368	498	2.25e-05
GO:BP	GO:0090257	regulation of muscle system process	143	177	2.47e-05
GO:BP	GO:0031032	actomyosin structure organization	148	184	2.56e-05
GO:BP	GO:0030198	extracellular matrix organization	176	223	2.56e-05
GO:BP	GO:1901652	response to peptide	278	368	2.56e-05
GO:BP	GO:0023057	negative regulation of signaling	731	1036	2.56e-05
GO:BP	GO:0050877	nervous system process	437	600	3.04e-05
GO:BP	GO:0022898	regulation of transmembrane transporter activity	115	139	3.12e-05
GO:BP	GO:0016358	dendrite development	147	183	3.23e-05
GO:BP	GO:0032970	regulation of actin filament-based process	230	300	3.47e-05
GO:BP	GO:1901653	cellular response to peptide	211	273	3.50e-05
GO:BP	GO:0048588	developmental cell growth	144	179	3.51e-05
GO:BP	GO:1901701	cellular response to oxygen-containing compound	569	796	3.79e-05
GO:BP	GO:0010033	response to organic substance	1193	1736	3.81e-05
GO:BP	GO:0150115	cell-substrate junction organization	82	95	3.82e-05
GO:BP	GO:0006816	calcium ion transport	203	262	4.05e-05
GO:BP	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	111	134	4.17e-05
GO:BP	GO:0043269	regulation of monoatomic ion transport	217	282	4.26e-05
GO:BP	GO:0010648	negative regulation of cell communication	728	1034	4.32e-05
GO:BP	GO:0050772	positive regulation of axonogenesis	58	64	4.56e-05
GO:BP	GO:0007423	sensory organ development	290	387	4.70e-05
GO:BP	GO:0072001	renal system development	190	244	4.80e-05
GO:BP	GO:0055085	transmembrane transport	652	921	5.07e-05
GO:BP	GO:1990778	protein localization to cell periphery	220	287	5.83e-05
GO:BP	GO:0065009	regulation of molecular function	903	1299	5.98e-05
GO:BP	GO:0032940	secretion by cell	402	551	5.98e-05
GO:BP	GO:0043547	positive regulation of GTPase activity	95	113	6.60e-05
GO:BP	GO:0009893	positive regulation of metabolic process	1769	2622	7.36e-05
GO:BP	GO:0070588	calcium ion transmembrane transport	165	210	8.86e-05
GO:BP	GO:0007044	cell-substrate junction assembly	76	88	8.86e-05
GO:BP	GO:0030100	regulation of endocytosis	155	196	8.93e-05
GO:BP	GO:0018212	peptidyl-tyrosine modification	132	164	8.96e-05
GO:BP	GO:0001667	ameboidal-type cell migration	259	344	8.96e-05
GO:BP	GO:0007186	G protein-coupled receptor signaling pathway	288	386	9.24e-05
GO:BP	GO:0009605	response to external stimulus	1073	1559	9.26e-05
GO:BP	GO:0045785	positive regulation of cell adhesion	229	301	9.26e-05
GO:BP	GO:0042592	homeostatic process	794	1137	9.38e-05
GO:BP	GO:0009968	negative regulation of signal transduction	684	972	9.94e-05
GO:BP	GO:1901888	regulation of cell junction assembly	126	156	1.05e-04
GO:BP	GO:0032535	regulation of cellular component size	219	287	1.05e-04
GO:BP	GO:0045216	cell-cell junction organization	123	152	1.14e-04
GO:BP	GO:0030048	actin filament-based movement	90	107	1.14e-04
GO:BP	GO:0001654	eye development	202	263	1.16e-04
GO:BP	GO:0048880	sensory system development	204	266	1.23e-04
GO:BP	GO:0051641	cellular localization	1767	2623	1.23e-04
GO:BP	GO:0048705	skeletal system morphogenesis	120	148	1.23e-04
GO:BP	GO:0048871	multicellular organismal-level homeostasis	390	536	1.25e-04
GO:BP	GO:0048738	cardiac muscle tissue development	158	201	1.30e-04
GO:BP	GO:0048598	embryonic morphogenesis	312	422	1.32e-04
GO:BP	GO:0060070	canonical Wnt signaling pathway	187	242	1.32e-04
GO:BP	GO:0018108	peptidyl-tyrosine phosphorylation	130	162	1.35e-04
GO:BP	GO:0035023	regulation of Rho protein signal transduction	58	65	1.40e-04
GO:BP	GO:0060560	developmental growth involved in morphogenesis	150	190	1.44e-04
GO:BP	GO:0071375	cellular response to peptide hormone stimulus	179	231	1.54e-04
GO:BP	GO:0043434	response to peptide hormone	237	314	1.64e-04
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	164	210	1.70e-04
GO:BP	GO:0042330	taxis	188	244	1.70e-04
GO:BP	GO:0006935	chemotaxis	188	244	1.70e-04
GO:BP	GO:0150063	visual system development	202	264	1.74e-04
GO:BP	GO:0032101	regulation of response to external stimulus	469	654	1.76e-04
GO:BP	GO:0001822	kidney development	183	237	1.76e-04
GO:BP	GO:0048167	regulation of synaptic plasticity	113	139	1.77e-04
GO:BP	GO:0043010	camera-type eye development	178	230	1.83e-04
GO:BP	GO:0061337	cardiac conduction	73	85	1.96e-04
GO:BP	GO:0051247	positive regulation of protein metabolic process	641	911	1.98e-04
GO:BP	GO:0071559	response to transforming growth factor beta	170	219	2.14e-04
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	167	215	2.41e-04
GO:BP	GO:1990138	neuron projection extension	109	134	2.43e-04
GO:BP	GO:0003018	vascular process in circulatory system	152	194	2.61e-04
GO:BP	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	78	92	2.61e-04
GO:BP	GO:0032870	cellular response to hormone stimulus	318	433	2.63e-04
GO:BP	GO:0009725	response to hormone	438	610	2.89e-04
GO:BP	GO:0007160	cell-matrix adhesion	134	169	2.95e-04
GO:BP	GO:0045165	cell fate commitment	121	151	3.13e-04
GO:BP	GO:0010976	positive regulation of neuron projection development	105	129	3.32e-04
GO:BP	GO:0001764	neuron migration	105	129	3.32e-04
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	158	203	3.37e-04
GO:BP	GO:0031401	positive regulation of protein modification process	397	550	3.39e-04
GO:BP	GO:0006898	receptor-mediated endocytosis	143	182	3.60e-04
GO:BP	GO:0035108	limb morphogenesis	91	110	3.63e-04
GO:BP	GO:0035107	appendage morphogenesis	91	110	3.63e-04
GO:BP	GO:0040013	negative regulation of locomotion	186	243	3.70e-04
GO:BP	GO:0061572	actin filament bundle organization	107	132	3.83e-04
GO:BP	GO:0010959	regulation of metal ion transport	183	239	4.18e-04
GO:BP	GO:0021537	telencephalon development	152	195	4.19e-04
GO:BP	GO:0060348	bone development	117	146	4.23e-04
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	147	188	4.27e-04
GO:BP	GO:0007610	behavior	308	420	4.27e-04
GO:BP	GO:0001952	regulation of cell-matrix adhesion	76	90	4.40e-04
GO:BP	GO:0007266	Rho protein signal transduction	90	109	4.62e-04
GO:BP	GO:0051017	actin filament bundle assembly	106	131	4.80e-04
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	337	463	4.89e-04
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	337	463	4.89e-04
GO:BP	GO:0072659	protein localization to plasma membrane	182	238	4.92e-04
GO:BP	GO:0060537	muscle tissue development	252	339	5.20e-04
GO:BP	GO:0043085	positive regulation of catalytic activity	393	546	5.51e-04
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	1624	2415	5.60e-04
GO:BP	GO:0051129	negative regulation of cellular component organization	399	555	5.66e-04
GO:BP	GO:0007163	establishment or maintenance of cell polarity	143	183	5.75e-04
GO:BP	GO:0048041	focal adhesion assembly	66	77	5.84e-04
GO:BP	GO:0010810	regulation of cell-substrate adhesion	128	162	5.96e-04
GO:BP	GO:0022604	regulation of cell morphogenesis	150	193	6.05e-04
GO:BP	GO:0038127	ERBB signaling pathway	86	104	6.18e-04
GO:BP	GO:0021955	central nervous system neuron axonogenesis	30	31	6.27e-04
GO:BP	GO:0002009	morphogenesis of an epithelium	272	369	6.93e-04
GO:BP	GO:0008361	regulation of cell size	117	147	7.27e-04
GO:BP	GO:0050900	leukocyte migration	151	195	7.99e-04
GO:BP	GO:0042327	positive regulation of phosphorylation	303	415	8.53e-04
GO:BP	GO:0046849	bone remodeling	52	59	8.81e-04
GO:BP	GO:0001649	osteoblast differentiation	136	174	8.81e-04
GO:BP	GO:0035725	sodium ion transmembrane transport	79	95	8.92e-04
GO:BP	GO:0043408	regulation of MAPK cascade	311	427	9.14e-04
GO:BP	GO:0008360	regulation of cell shape	87	106	9.57e-04
GO:BP	GO:0110020	regulation of actomyosin structure organization	73	87	9.68e-04
GO:BP	GO:0001775	cell activation	446	627	9.73e-04
GO:BP	GO:0090130	tissue migration	187	247	1.03e-03
GO:BP	GO:0050807	regulation of synapse organization	135	173	1.07e-03
GO:BP	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	120	152	1.12e-03
GO:BP	GO:0090132	epithelium migration	184	243	1.16e-03
GO:BP	GO:0010631	epithelial cell migration	184	243	1.16e-03
GO:BP	GO:0051494	negative regulation of cytoskeleton organization	102	127	1.17e-03
GO:BP	GO:0002063	chondrocyte development	23	23	1.19e-03
GO:BP	GO:0051336	regulation of hydrolase activity	313	431	1.23e-03
GO:BP	GO:0007229	integrin-mediated signaling pathway	72	86	1.25e-03
GO:BP	GO:1902903	regulation of supramolecular fiber organization	226	304	1.31e-03
GO:BP	GO:0006814	sodium ion transport	109	137	1.36e-03
GO:BP	GO:0006936	muscle contraction	192	255	1.39e-03
GO:BP	GO:0051962	positive regulation of nervous system development	162	212	1.42e-03
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	212	284	1.44e-03
GO:BP	GO:0000165	MAPK cascade	362	504	1.46e-03
GO:BP	GO:0021987	cerebral cortex development	77	93	1.46e-03
GO:BP	GO:0034103	regulation of tissue remodeling	40	44	1.46e-03
GO:BP	GO:0008283	cell population proliferation	895	1306	1.46e-03
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	1470	2186	1.47e-03
GO:BP	GO:0050920	regulation of chemotaxis	106	133	1.47e-03
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	196	261	1.49e-03
GO:BP	GO:0031623	receptor internalization	74	89	1.52e-03
GO:BP	GO:0051050	positive regulation of transport	407	571	1.52e-03
GO:BP	GO:0009611	response to wounding	279	382	1.56e-03
GO:BP	GO:0021954	central nervous system neuron development	50	57	1.56e-03
GO:BP	GO:0032231	regulation of actin filament bundle assembly	71	85	1.58e-03
GO:BP	GO:0050769	positive regulation of neurogenesis	142	184	1.71e-03
GO:BP	GO:0048592	eye morphogenesis	87	107	1.76e-03
GO:BP	GO:2000146	negative regulation of cell motility	165	217	1.86e-03
GO:BP	GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	194	259	2.06e-03
GO:BP	GO:0050803	regulation of synapse structure or activity	136	176	2.19e-03
GO:BP	GO:1902893	regulation of miRNA transcription	52	60	2.23e-03
GO:BP	GO:0006835	dicarboxylic acid transport	52	60	2.23e-03
GO:BP	GO:0150116	regulation of cell-substrate junction organization	52	60	2.23e-03
GO:BP	GO:0098900	regulation of action potential	35	38	2.23e-03
GO:BP	GO:0031345	negative regulation of cell projection organization	114	145	2.24e-03
GO:BP	GO:0010232	vascular transport	58	68	2.27e-03
GO:BP	GO:0043502	regulation of muscle adaptation	58	68	2.27e-03
GO:BP	GO:0150104	transport across blood-brain barrier	58	68	2.27e-03
GO:BP	GO:0043149	stress fiber assembly	75	91	2.33e-03
GO:BP	GO:0030038	contractile actin filament bundle assembly	75	91	2.33e-03
GO:BP	GO:0070252	actin-mediated cell contraction	72	87	2.49e-03
GO:BP	GO:0010977	negative regulation of neuron projection development	88	109	2.55e-03
GO:BP	GO:0071695	anatomical structure maturation	118	151	2.67e-03
GO:BP	GO:0003205	cardiac chamber development	118	151	2.67e-03
GO:BP	GO:0003007	heart morphogenesis	165	218	2.72e-03
GO:BP	GO:0048259	regulation of receptor-mediated endocytosis	66	79	2.74e-03
GO:BP	GO:0030278	regulation of ossification	66	79	2.74e-03
GO:BP	GO:0051893	regulation of focal adhesion assembly	48	55	2.80e-03
GO:BP	GO:0051057	positive regulation of small GTPase mediated signal transduction	48	55	2.80e-03
GO:BP	GO:0090109	regulation of cell-substrate junction assembly	48	55	2.80e-03
GO:BP	GO:0098901	regulation of cardiac muscle cell action potential	26	27	2.81e-03
GO:BP	GO:0001934	positive regulation of protein phosphorylation	287	396	2.91e-03
GO:BP	GO:0086001	cardiac muscle cell action potential	54	63	2.96e-03
GO:BP	GO:0061351	neural precursor cell proliferation	95	119	2.96e-03
GO:BP	GO:0051345	positive regulation of hydrolase activity	198	266	3.05e-03
GO:BP	GO:1902305	regulation of sodium ion transmembrane transport	34	37	3.06e-03
GO:BP	GO:0051174	regulation of phosphorus metabolic process	561	805	3.08e-03
GO:BP	GO:0042692	muscle cell differentiation	237	323	3.24e-03
GO:BP	GO:0097553	calcium ion transmembrane import into cytosol	97	122	3.32e-03
GO:BP	GO:0019220	regulation of phosphate metabolic process	560	804	3.39e-03
GO:BP	GO:0030336	negative regulation of cell migration	159	210	3.40e-03
GO:BP	GO:0048762	mesenchymal cell differentiation	152	200	3.45e-03
GO:BP	GO:0048008	platelet-derived growth factor receptor signaling pathway	44	50	3.50e-03
GO:BP	GO:0050890	cognition	161	213	3.55e-03
GO:BP	GO:0014897	striated muscle hypertrophy	62	74	3.63e-03
GO:BP	GO:1902904	negative regulation of supramolecular fiber organization	99	125	3.68e-03
GO:BP	GO:0002028	regulation of sodium ion transport	50	58	3.84e-03
GO:BP	GO:0060485	mesenchyme development	183	245	3.90e-03
GO:BP	GO:0051493	regulation of cytoskeleton organization	297	412	4.02e-03
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	106	135	4.03e-03
GO:BP	GO:0099003	vesicle-mediated transport in synapse	130	169	4.10e-03
GO:BP	GO:0010817	regulation of hormone levels	233	318	4.14e-03
GO:BP	GO:0050768	negative regulation of neurogenesis	83	103	4.27e-03
GO:BP	GO:0051051	negative regulation of transport	211	286	4.31e-03
GO:BP	GO:0002521	leukocyte differentiation	269	371	4.31e-03
GO:BP	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	108	138	4.37e-03
GO:BP	GO:1902905	positive regulation of supramolecular fiber organization	108	138	4.37e-03
GO:BP	GO:0006909	phagocytosis	108	138	4.37e-03
GO:BP	GO:0048469	cell maturation	88	110	4.37e-03
GO:BP	GO:0051492	regulation of stress fiber assembly	64	77	4.39e-03
GO:BP	GO:0031325	positive regulation of cellular metabolic process	1559	2333	4.39e-03
GO:BP	GO:0021953	central nervous system neuron differentiation	80	99	4.60e-03
GO:BP	GO:0003300	cardiac muscle hypertrophy	61	73	4.61e-03
GO:BP	GO:0007259	receptor signaling pathway via JAK-STAT	72	88	4.62e-03
GO:BP	GO:0010632	regulation of epithelial cell migration	143	188	4.83e-03
GO:BP	GO:0098771	inorganic ion homeostasis	253	348	4.95e-03
GO:BP	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels	52	61	4.98e-03
GO:BP	GO:0061614	miRNA transcription	52	61	4.98e-03
GO:BP	GO:0036211	protein modification process	1531	2291	4.98e-03
GO:BP	GO:0018105	peptidyl-serine phosphorylation	124	161	5.05e-03
GO:BP	GO:0031099	regeneration	112	144	5.09e-03
GO:BP	GO:0007179	transforming growth factor beta receptor signaling pathway	131	171	5.09e-03
GO:BP	GO:0001508	action potential	82	102	5.19e-03
GO:BP	GO:0045664	regulation of neuron differentiation	102	130	5.33e-03
GO:BP	GO:0034764	positive regulation of transmembrane transport	102	130	5.33e-03
GO:BP	GO:1903530	regulation of secretion by cell	265	366	5.34e-03
GO:BP	GO:0097696	receptor signaling pathway via STAT	74	91	5.34e-03
GO:BP	GO:0099173	postsynapse organization	114	147	5.45e-03
GO:BP	GO:0035113	embryonic appendage morphogenesis	71	87	5.77e-03
GO:BP	GO:0030326	embryonic limb morphogenesis	71	87	5.77e-03
GO:BP	GO:0046622	positive regulation of organ growth	32	35	5.77e-03
GO:BP	GO:0042063	gliogenesis	180	242	5.95e-03
GO:BP	GO:0008366	axon ensheathment	94	119	5.95e-03
GO:BP	GO:0007272	ensheathment of neurons	94	119	5.95e-03
GO:BP	GO:0042127	regulation of cell population proliferation	738	1077	5.96e-03
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	498	714	5.99e-03
GO:BP	GO:0051046	regulation of secretion	285	396	5.99e-03
GO:BP	GO:0023061	signal release	230	315	5.99e-03
GO:BP	GO:0030500	regulation of bone mineralization	42	48	6.06e-03
GO:BP	GO:0046850	regulation of bone remodeling	28	30	6.06e-03
GO:BP	GO:0030097	hemopoiesis	438	624	6.06e-03
GO:BP	GO:0048736	appendage development	106	136	6.18e-03
GO:BP	GO:0060173	limb development	106	136	6.18e-03
GO:BP	GO:0060341	regulation of cellular localization	539	776	6.18e-03
GO:BP	GO:0090596	sensory organ morphogenesis	132	173	6.26e-03
GO:BP	GO:0002376	immune system process	956	1410	6.44e-03
GO:BP	GO:0110053	regulation of actin filament organization	159	212	6.73e-03
GO:BP	GO:0031399	regulation of protein modification process	628	911	6.73e-03
GO:BP	GO:0014896	muscle hypertrophy	62	75	6.97e-03
GO:BP	GO:0018209	peptidyl-serine modification	129	169	7.06e-03
GO:BP	GO:0007173	epidermal growth factor receptor signaling pathway	70	86	7.13e-03
GO:BP	GO:0071407	cellular response to organic cyclic compound	273	379	7.15e-03
GO:BP	GO:0048813	dendrite morphogenesis	88	111	7.16e-03
GO:BP	GO:0046777	protein autophosphorylation	110	142	7.19e-03
GO:BP	GO:0010721	negative regulation of cell development	138	182	7.31e-03
GO:BP	GO:0021543	pallium development	105	135	7.45e-03
GO:BP	GO:0043410	positive regulation of MAPK cascade	211	288	7.49e-03
GO:BP	GO:0051246	regulation of protein metabolic process	1076	1595	7.49e-03
GO:BP	GO:0120031	plasma membrane bounded cell projection assembly	312	437	7.49e-03
GO:BP	GO:0007162	negative regulation of cell adhesion	140	185	7.64e-03
GO:BP	GO:0051495	positive regulation of cytoskeleton organization	112	145	7.67e-03
GO:BP	GO:0071711	basement membrane organization	31	34	7.74e-03
GO:BP	GO:0032330	regulation of chondrocyte differentiation	31	34	7.74e-03
GO:BP	GO:1990845	adaptive thermogenesis	95	121	7.74e-03
GO:BP	GO:0033043	regulation of organelle organization	655	953	7.85e-03
GO:BP	GO:0014743	regulation of muscle hypertrophy	41	47	7.91e-03
GO:BP	GO:0098868	bone growth	23	24	7.95e-03
GO:BP	GO:0021952	central nervous system projection neuron axonogenesis	23	24	7.95e-03
GO:BP	GO:0050773	regulation of dendrite development	64	78	8.09e-03
GO:BP	GO:0030282	bone mineralization	64	78	8.09e-03
GO:BP	GO:0010743	regulation of macrophage derived foam cell differentiation	18	18	8.15e-03
GO:BP	GO:1990776	response to angiotensin	27	29	8.32e-03
GO:BP	GO:0150117	positive regulation of cell-substrate junction organization	27	29	8.32e-03
GO:BP	GO:0033036	macromolecule localization	1539	2309	8.54e-03
GO:BP	GO:0042552	myelination	92	117	8.54e-03
GO:BP	GO:0003206	cardiac chamber morphogenesis	87	110	8.58e-03
GO:BP	GO:0043270	positive regulation of monoatomic ion transport	99	127	9.13e-03
GO:BP	GO:0060249	anatomical structure homeostasis	125	164	9.15e-03
GO:BP	GO:0046620	regulation of organ growth	58	70	9.15e-03
GO:BP	GO:0001894	tissue homeostasis	125	164	9.15e-03
GO:BP	GO:0030031	cell projection assembly	318	447	9.45e-03
GO:BP	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	89	113	9.46e-03
GO:BP	GO:0031214	biomineral tissue development	84	106	9.47e-03
GO:BP	GO:0007043	cell-cell junction assembly	84	106	9.47e-03
GO:BP	GO:0046942	carboxylic acid transport	152	203	9.60e-03
GO:BP	GO:0007517	muscle organ development	196	267	9.60e-03
GO:BP	GO:0040008	regulation of growth	328	462	9.60e-03
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	183	248	9.60e-03
GO:BP	GO:0120032	regulation of plasma membrane bounded cell projection assembly	120	157	9.60e-03
GO:BP	GO:0001659	temperature homeostasis	101	130	9.71e-03
GO:BP	GO:0061387	regulation of extent of cell growth	71	88	9.90e-03
GO:BP	GO:0032271	regulation of protein polymerization	122	160	1.02e-02
GO:BP	GO:0060048	cardiac muscle contraction	91	116	1.02e-02
GO:BP	GO:0048675	axon extension	76	95	1.02e-02
GO:BP	GO:0010611	regulation of cardiac muscle hypertrophy	40	46	1.03e-02
GO:BP	GO:0060350	endochondral bone morphogenesis	40	46	1.03e-02
GO:BP	GO:0051961	negative regulation of nervous system development	86	109	1.03e-02
GO:BP	GO:0018193	peptidyl-amino acid modification	390	555	1.03e-02
GO:BP	GO:0014070	response to organic cyclic compound	424	606	1.03e-02
GO:BP	GO:0086065	cell communication involved in cardiac conduction	46	54	1.04e-02
GO:BP	GO:0051924	regulation of calcium ion transport	117	153	1.07e-02
GO:BP	GO:0060349	bone morphogenesis	60	73	1.07e-02
GO:BP	GO:0006937	regulation of muscle contraction	98	126	1.07e-02
GO:BP	GO:0007611	learning or memory	142	189	1.11e-02
GO:BP	GO:0003416	endochondral bone growth	22	23	1.11e-02
GO:BP	GO:0007159	leukocyte cell-cell adhesion	162	218	1.12e-02
GO:BP	GO:0016266	O-glycan processing	26	28	1.14e-02
GO:BP	GO:0006887	exocytosis	175	237	1.16e-02
GO:BP	GO:0022407	regulation of cell-cell adhesion	203	278	1.18e-02
GO:BP	GO:0032528	microvillus organization	17	17	1.18e-02
GO:BP	GO:0070727	cellular macromolecule localization	1343	2010	1.18e-02
GO:BP	GO:0060491	regulation of cell projection assembly	121	159	1.18e-02
GO:BP	GO:0015800	acidic amino acid transport	33	37	1.19e-02
GO:BP	GO:0002685	regulation of leukocyte migration	95	122	1.19e-02
GO:BP	GO:0098739	import across plasma membrane	95	122	1.19e-02
GO:BP	GO:0060291	long-term synaptic potentiation	54	65	1.19e-02
GO:BP	GO:0032272	negative regulation of protein polymerization	54	65	1.19e-02
GO:BP	GO:0007613	memory	70	87	1.20e-02
GO:BP	GO:0097191	extrinsic apoptotic signaling pathway	130	172	1.21e-02
GO:BP	GO:0003231	cardiac ventricle development	90	115	1.21e-02
GO:BP	GO:1901342	regulation of vasculature development	148	198	1.22e-02
GO:BP	GO:1901890	positive regulation of cell junction assembly	62	76	1.23e-02
GO:BP	GO:0033002	muscle cell proliferation	116	152	1.24e-02
GO:BP	GO:0048678	response to axon injury	51	61	1.25e-02
GO:BP	GO:0008104	protein localization	1336	2000	1.26e-02
GO:BP	GO:0031103	axon regeneration	36	41	1.27e-02
GO:BP	GO:0051899	membrane depolarization	48	57	1.30e-02
GO:BP	GO:0050921	positive regulation of chemotaxis	67	83	1.30e-02
GO:BP	GO:0015849	organic acid transport	152	204	1.30e-02
GO:BP	GO:0050790	regulation of catalytic activity	613	893	1.31e-02
GO:BP	GO:2000628	regulation of miRNA metabolic process	59	72	1.32e-02
GO:BP	GO:1903053	regulation of extracellular matrix organization	42	49	1.34e-02
GO:BP	GO:0006954	inflammatory response	302	425	1.35e-02
GO:BP	GO:0030855	epithelial cell differentiation	304	428	1.35e-02
GO:BP	GO:0045765	regulation of angiogenesis	145	194	1.35e-02
GO:BP	GO:0060562	epithelial tube morphogenesis	191	261	1.35e-02
GO:BP	GO:0042325	regulation of phosphorylation	474	683	1.37e-02
GO:BP	GO:0043068	positive regulation of programmed cell death	277	388	1.39e-02
GO:BP	GO:0045927	positive regulation of growth	138	184	1.41e-02
GO:BP	GO:0099504	synaptic vesicle cycle	115	151	1.46e-02
GO:BP	GO:0010876	lipid localization	216	298	1.47e-02
GO:BP	GO:0032880	regulation of protein localization	479	691	1.48e-02
GO:BP	GO:0086003	cardiac muscle cell contraction	53	64	1.50e-02
GO:BP	GO:0055017	cardiac muscle tissue growth	53	64	1.50e-02
GO:BP	GO:1904646	cellular response to amyloid-beta	25	27	1.55e-02
GO:BP	GO:1904385	cellular response to angiotensin	25	27	1.55e-02
GO:BP	GO:0010634	positive regulation of epithelial cell migration	98	127	1.63e-02
GO:BP	GO:0060419	heart growth	58	71	1.66e-02
GO:BP	GO:0050673	epithelial cell proliferation	217	300	1.70e-02
GO:BP	GO:0071805	potassium ion transmembrane transport	93	120	1.70e-02
GO:BP	GO:0048568	embryonic organ development	219	303	1.71e-02
GO:BP	GO:0051653	spindle localization	44	52	1.71e-02
GO:BP	GO:0021846	cell proliferation in forebrain	16	16	1.71e-02
GO:BP	GO:1903131	mononuclear cell differentiation	202	278	1.72e-02
GO:BP	GO:0006874	intracellular calcium ion homeostasis	150	202	1.74e-02
GO:BP	GO:0051058	negative regulation of small GTPase mediated signal transduction	41	48	1.74e-02
GO:BP	GO:0031102	neuron projection regeneration	41	48	1.74e-02
GO:BP	GO:0055006	cardiac cell development	63	78	1.75e-02
GO:BP	GO:0055001	muscle cell development	123	163	1.76e-02
GO:BP	GO:0010717	regulation of epithelial to mesenchymal transition	68	85	1.81e-02
GO:BP	GO:1904645	response to amyloid-beta	28	31	1.90e-02
GO:BP	GO:0032411	positive regulation of transporter activity	52	63	1.90e-02
GO:BP	GO:0031644	regulation of nervous system process	60	74	1.91e-02
GO:BP	GO:0048864	stem cell development	60	74	1.91e-02
GO:BP	GO:0016049	cell growth	272	382	1.92e-02
GO:BP	GO:0000003	reproduction	604	882	1.92e-02
GO:BP	GO:0006942	regulation of striated muscle contraction	65	81	1.99e-02
GO:BP	GO:0003279	cardiac septum development	80	102	2.00e-02
GO:BP	GO:0010638	positive regulation of organelle organization	290	409	2.01e-02
GO:BP	GO:0014855	striated muscle cell proliferation	49	59	2.01e-02
GO:BP	GO:0007265	Ras protein signal transduction	75	95	2.02e-02
GO:BP	GO:0043588	skin development	131	175	2.07e-02
GO:BP	GO:0106106	cold-induced thermogenesis	87	112	2.10e-02
GO:BP	GO:0008038	neuron recognition	31	35	2.11e-02
GO:BP	GO:0045663	positive regulation of myoblast differentiation	31	35	2.11e-02
GO:BP	GO:0021799	cerebral cortex radially oriented cell migration	24	26	2.16e-02
GO:BP	GO:0051235	maintenance of location	183	251	2.20e-02
GO:BP	GO:0045667	regulation of osteoblast differentiation	77	98	2.22e-02
GO:BP	GO:0046578	regulation of Ras protein signal transduction	34	39	2.23e-02
GO:BP	GO:0034767	positive regulation of monoatomic ion transmembrane transport	72	91	2.24e-02
GO:BP	GO:0045665	negative regulation of neuron differentiation	37	43	2.27e-02
GO:BP	GO:0002090	regulation of receptor internalization	37	43	2.27e-02
GO:BP	GO:0055074	calcium ion homeostasis	159	216	2.27e-02
GO:BP	GO:0006813	potassium ion transport	103	135	2.29e-02
GO:BP	GO:1903169	regulation of calcium ion transmembrane transport	84	108	2.34e-02
GO:BP	GO:0043065	positive regulation of apoptotic process	270	380	2.37e-02
GO:BP	GO:0070167	regulation of biomineral tissue development	51	62	2.39e-02
GO:BP	GO:0044272	sulfur compound biosynthetic process	98	128	2.44e-02
GO:BP	GO:0010586	miRNA metabolic process	69	87	2.47e-02
GO:BP	GO:0048593	camera-type eye morphogenesis	69	87	2.47e-02
GO:BP	GO:1904375	regulation of protein localization to cell periphery	86	111	2.52e-02
GO:BP	GO:0120161	regulation of cold-induced thermogenesis	86	111	2.52e-02
GO:BP	GO:0032414	positive regulation of ion transmembrane transporter activity	48	58	2.55e-02
GO:BP	GO:0001974	blood vessel remodeling	27	30	2.57e-02
GO:BP	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	27	30	2.57e-02
GO:BP	GO:0120162	positive regulation of cold-induced thermogenesis	56	69	2.57e-02
GO:BP	GO:0046486	glycerolipid metabolic process	205	284	2.57e-02
GO:BP	GO:0051146	striated muscle cell differentiation	171	234	2.57e-02
GO:BP	GO:0071396	cellular response to lipid	275	388	2.66e-02
GO:BP	GO:0006950	response to stress	1680	2540	2.66e-02
GO:BP	GO:0014910	regulation of smooth muscle cell migration	45	54	2.69e-02
GO:BP	GO:0090263	positive regulation of canonical Wnt signaling pathway	66	83	2.72e-02
GO:BP	GO:0051648	vesicle localization	140	189	2.80e-02
GO:BP	GO:0010927	cellular component assembly involved in morphogenesis	83	107	2.80e-02
GO:BP	GO:0031667	response to nutrient levels	252	354	2.80e-02
GO:BP	GO:0008285	negative regulation of cell population proliferation	329	469	2.81e-02
GO:BP	GO:0021795	cerebral cortex cell migration	30	34	2.81e-02
GO:BP	GO:2001236	regulation of extrinsic apoptotic signaling pathway	90	117	2.86e-02
GO:BP	GO:0006629	lipid metabolic process	629	923	2.89e-02
GO:BP	GO:0055013	cardiac muscle cell development	58	72	2.93e-02
GO:BP	GO:0046503	glycerolipid catabolic process	33	38	2.93e-02
GO:BP	GO:1904407	positive regulation of nitric oxide metabolic process	23	25	2.94e-02
GO:BP	GO:0060351	cartilage development involved in endochondral bone morphogenesis	23	25	2.94e-02
GO:BP	GO:0001954	positive regulation of cell-matrix adhesion	36	42	2.94e-02
GO:BP	GO:0022612	gland morphogenesis	73	93	2.94e-02
GO:BP	GO:0033993	response to lipid	398	573	2.94e-02
GO:BP	GO:0030705	cytoskeleton-dependent intracellular transport	133	179	2.94e-02
GO:BP	GO:0006869	lipid transport	189	261	2.96e-02
GO:BP	GO:0030177	positive regulation of Wnt signaling pathway	85	110	2.97e-02
GO:BP	GO:0051043	regulation of membrane protein ectodomain proteolysis	19	20	3.09e-02
GO:BP	GO:0071675	regulation of mononuclear cell migration	55	68	3.18e-02
GO:BP	GO:0019915	lipid storage	55	68	3.18e-02
GO:BP	GO:0007584	response to nutrient	87	113	3.18e-02
GO:BP	GO:0055123	digestive system development	75	96	3.20e-02
GO:BP	GO:0006941	striated muscle contraction	110	146	3.22e-02
GO:BP	GO:0009914	hormone transport	152	207	3.22e-02
GO:BP	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	60	75	3.27e-02
GO:BP	GO:0045321	leukocyte activation	369	530	3.29e-02
GO:BP	GO:0007416	synapse assembly	103	136	3.31e-02
GO:BP	GO:0046661	male sex differentiation	82	106	3.31e-02
GO:BP	GO:0050806	positive regulation of synaptic transmission	82	106	3.31e-02
GO:BP	GO:0022414	reproductive process	596	874	3.38e-02
GO:BP	GO:2000649	regulation of sodium ion transmembrane transporter activity	26	29	3.43e-02
GO:BP	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	26	29	3.43e-02
GO:BP	GO:0001932	regulation of protein phosphorylation	443	642	3.48e-02
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	84	109	3.55e-02
GO:BP	GO:1904705	regulation of vascular associated smooth muscle cell proliferation	41	49	3.56e-02
GO:BP	GO:1903078	positive regulation of protein localization to plasma membrane	41	49	3.56e-02
GO:BP	GO:0060998	regulation of dendritic spine development	41	49	3.56e-02
GO:BP	GO:0060420	regulation of heart growth	41	49	3.56e-02
GO:BP	GO:0106027	neuron projection organization	57	71	3.57e-02
GO:BP	GO:0021700	developmental maturation	149	203	3.58e-02
GO:BP	GO:0008037	cell recognition	62	78	3.62e-02
GO:BP	GO:0040019	positive regulation of embryonic development	14	14	3.63e-02
GO:BP	GO:0086069	bundle of His cell to Purkinje myocyte communication	14	14	3.63e-02
GO:BP	GO:0030522	intracellular receptor signaling pathway	183	253	3.64e-02
GO:BP	GO:0042100	B cell proliferation	38	45	3.68e-02
GO:BP	GO:0007260	tyrosine phosphorylation of STAT protein	29	33	3.68e-02
GO:BP	GO:0015711	organic anion transport	185	256	3.68e-02
GO:BP	GO:1904377	positive regulation of protein localization to cell periphery	49	60	3.68e-02
GO:BP	GO:0001763	morphogenesis of a branching structure	109	145	3.71e-02
GO:BP	GO:0045453	bone resorption	35	41	3.76e-02
GO:BP	GO:0010171	body morphogenesis	35	41	3.76e-02
GO:BP	GO:1903115	regulation of actin filament-based movement	32	37	3.77e-02
GO:BP	GO:0010811	positive regulation of cell-substrate adhesion	74	95	3.79e-02
GO:BP	GO:0050870	positive regulation of T cell activation	102	135	3.82e-02
GO:BP	GO:0008154	actin polymerization or depolymerization	111	148	3.84e-02
GO:BP	GO:0002064	epithelial cell development	111	148	3.84e-02
GO:BP	GO:1901343	negative regulation of vasculature development	54	67	3.85e-02
GO:BP	GO:0060411	cardiac septum morphogenesis	54	67	3.85e-02
GO:BP	GO:2000181	negative regulation of blood vessel morphogenesis	54	67	3.85e-02
GO:BP	GO:1903076	regulation of protein localization to plasma membrane	69	88	3.87e-02
GO:BP	GO:0006638	neutral lipid metabolic process	69	88	3.87e-02
GO:BP	GO:0008217	regulation of blood pressure	81	105	3.87e-02
GO:BP	GO:0060041	retina development in camera-type eye	81	105	3.87e-02
GO:BP	GO:1902107	positive regulation of leukocyte differentiation	88	115	3.89e-02
GO:BP	GO:1903708	positive regulation of hemopoiesis	88	115	3.89e-02
GO:BP	GO:0001823	mesonephros development	59	74	3.89e-02
GO:BP	GO:0030516	regulation of axon extension	59	74	3.89e-02
GO:BP	GO:0003229	ventricular cardiac muscle tissue development	46	56	3.89e-02
GO:BP	GO:0051894	positive regulation of focal adhesion assembly	22	24	3.92e-02
GO:BP	GO:0045429	positive regulation of nitric oxide biosynthetic process	22	24	3.92e-02
GO:BP	GO:0002431	Fc receptor mediated stimulatory signaling pathway	22	24	3.92e-02
GO:BP	GO:0045124	regulation of bone resorption	22	24	3.92e-02
GO:BP	GO:0050678	regulation of epithelial cell proliferation	180	249	3.95e-02
GO:BP	GO:0046879	hormone secretion	148	202	3.97e-02
GO:BP	GO:0007389	pattern specification process	205	286	3.99e-02
GO:BP	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	71	91	4.16e-02
GO:BP	GO:0071378	cellular response to growth hormone stimulus	18	19	4.23e-02
GO:BP	GO:0051650	establishment of vesicle localization	128	173	4.23e-02
GO:BP	GO:0035270	endocrine system development	66	84	4.26e-02
GO:BP	GO:0002684	positive regulation of immune system process	401	580	4.27e-02
GO:BP	GO:1901879	regulation of protein depolymerization	56	70	4.28e-02
GO:BP	GO:0014033	neural crest cell differentiation	61	77	4.30e-02
GO:BP	GO:0072073	kidney epithelium development	85	111	4.33e-02
GO:BP	GO:0001755	neural crest cell migration	40	48	4.41e-02
GO:BP	GO:0051293	establishment of spindle localization	40	48	4.41e-02
GO:BP	GO:0015833	peptide transport	132	179	4.44e-02
GO:BP	GO:0060421	positive regulation of heart growth	25	28	4.49e-02
GO:BP	GO:0030041	actin filament polymerization	94	124	4.51e-02
GO:BP	GO:0042060	wound healing	208	291	4.55e-02
GO:BP	GO:0030073	insulin secretion	103	137	4.57e-02
GO:BP	GO:0055021	regulation of cardiac muscle tissue growth	37	44	4.60e-02
GO:BP	GO:0006639	acylglycerol metabolic process	68	87	4.60e-02
GO:BP	GO:1902895	positive regulation of miRNA transcription	37	44	4.60e-02
GO:BP	GO:0086002	cardiac muscle cell action potential involved in contraction	37	44	4.60e-02
GO:BP	GO:0003006	developmental process involved in reproduction	396	573	4.63e-02
GO:BP	GO:0051668	localization within membrane	392	567	4.66e-02
GO:BP	GO:0071230	cellular response to amino acid stimulus	53	66	4.66e-02
GO:BP	GO:0016525	negative regulation of angiogenesis	53	66	4.66e-02
GO:BP	GO:0007369	gastrulation	105	140	4.71e-02
GO:BP	GO:0072164	mesonephric tubule development	58	73	4.71e-02
GO:BP	GO:0072163	mesonephric epithelium development	58	73	4.71e-02
GO:BP	GO:0042509	regulation of tyrosine phosphorylation of STAT protein	28	32	4.71e-02
GO:BP	GO:0086004	regulation of cardiac muscle cell contraction	28	32	4.71e-02
GO:BP	GO:0098927	vesicle-mediated transport between endosomal compartments	34	40	4.72e-02
GO:BP	GO:0008277	regulation of G protein-coupled receptor signaling pathway	75	97	4.72e-02
GO:BP	GO:0006865	amino acid transport	75	97	4.72e-02
GO:BP	GO:0038179	neurotrophin signaling pathway	31	36	4.77e-02
GO:BP	GO:0031641	regulation of myelination	31	36	4.77e-02
GO:BP	GO:0003073	regulation of systemic arterial blood pressure	45	55	4.79e-02
GO:BP	GO:0042246	tissue regeneration	45	55	4.79e-02
GO:BP	GO:0043254	regulation of protein-containing complex assembly	232	327	4.79e-02
GO:BP	GO:0002682	regulation of immune system process	590	868	4.85e-02

LRnomtable_20k %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in LR nESRgenes_20k") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in LR nESRgenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:04360	Axon guidance	130	155	5.82e-06
KEGG	KEGG:04971	Gastric acid secretion	49	51	6.86e-06
KEGG	KEGG:04022	cGMP-PKG signaling pathway	109	129	8.01e-06
KEGG	KEGG:04015	Rap1 signaling pathway	133	162	8.01e-06
KEGG	KEGG:04024	cAMP signaling pathway	122	147	8.01e-06
KEGG	KEGG:04520	Adherens junction	74	83	8.01e-06
KEGG	KEGG:04270	Vascular smooth muscle contraction	81	92	8.01e-06
KEGG	KEGG:04020	Calcium signaling pathway	132	161	9.13e-06
KEGG	KEGG:04911	Insulin secretion	57	62	9.72e-06
KEGG	KEGG:04014	Ras signaling pathway	134	164	9.72e-06
KEGG	KEGG:04925	Aldosterone synthesis and secretion	67	75	1.26e-05
KEGG	KEGG:04810	Regulation of actin cytoskeleton	137	169	1.34e-05
KEGG	KEGG:04928	Parathyroid hormone synthesis, secretion and action	69	78	1.74e-05
KEGG	KEGG:04510	Focal adhesion	136	169	2.83e-05
KEGG	KEGG:04611	Platelet activation	76	88	3.64e-05
KEGG	KEGG:04974	Protein digestion and absorption	51	56	5.62e-05
KEGG	KEGG:04927	Cortisol synthesis and secretion	43	46	5.69e-05
KEGG	KEGG:05200	Pathways in cancer	290	391	6.90e-05
KEGG	KEGG:04261	Adrenergic signaling in cardiomyocytes	102	124	6.90e-05
KEGG	KEGG:04970	Salivary secretion	49	54	9.33e-05
KEGG	KEGG:05146	Amoebiasis	55	62	1.27e-04
KEGG	KEGG:04010	MAPK signaling pathway	177	231	1.88e-04
KEGG	KEGG:04750	Inflammatory mediator regulation of TRP channels	62	72	2.63e-04
KEGG	KEGG:04713	Circadian entrainment	59	68	2.63e-04
KEGG	KEGG:05163	Human cytomegalovirus infection	126	160	3.03e-04
KEGG	KEGG:04151	PI3K-Akt signaling pathway	189	250	3.54e-04
KEGG	KEGG:04961	Endocrine and other factor-regulated calcium reabsorption	37	40	3.64e-04
KEGG	KEGG:04512	ECM-receptor interaction	57	66	4.11e-04
KEGG	KEGG:04918	Thyroid hormone synthesis	47	53	4.46e-04
KEGG	KEGG:04972	Pancreatic secretion	50	57	4.65e-04
KEGG	KEGG:04730	Long-term depression	36	39	4.65e-04
KEGG	KEGG:05205	Proteoglycans in cancer	126	162	6.91e-04
KEGG	KEGG:04933	AGE-RAGE signaling pathway in diabetic complications	72	87	7.24e-04
KEGG	KEGG:05412	Arrhythmogenic right ventricular cardiomyopathy	57	67	8.62e-04
KEGG	KEGG:04728	Dopaminergic synapse	79	97	9.25e-04
KEGG	KEGG:04924	Renin secretion	44	50	9.91e-04
KEGG	KEGG:04926	Relaxin signaling pathway	81	100	1.02e-03
KEGG	KEGG:04976	Bile secretion	37	41	1.02e-03
KEGG	KEGG:04148	Efferocytosis	95	120	1.37e-03
KEGG	KEGG:04915	Estrogen signaling pathway	73	90	1.91e-03
KEGG	KEGG:05135	Yersinia infection	85	107	2.20e-03
KEGG	KEGG:05414	Dilated cardiomyopathy	67	82	2.20e-03
KEGG	KEGG:04072	Phospholipase D signaling pathway	85	107	2.20e-03
KEGG	KEGG:04720	Long-term potentiation	44	51	2.26e-03
KEGG	KEGG:04935	Growth hormone synthesis, secretion and action	77	96	2.30e-03
KEGG	KEGG:04726	Serotonergic synapse	49	58	2.90e-03
KEGG	KEGG:05417	Lipid and atherosclerosis	110	143	2.96e-03
KEGG	KEGG:04670	Leukocyte transendothelial migration	62	76	3.51e-03
KEGG	KEGG:00000	KEGG root term	3552	5451	3.54e-03
KEGG	KEGG:04371	Apelin signaling pathway	82	104	3.80e-03
KEGG	KEGG:04725	Cholinergic synapse	66	82	4.54e-03
KEGG	KEGG:04921	Oxytocin signaling pathway	88	113	4.91e-03
KEGG	KEGG:04310	Wnt signaling pathway	102	133	5.10e-03
KEGG	KEGG:04724	Glutamatergic synapse	60	74	5.24e-03
KEGG	KEGG:05410	Hypertrophic cardiomyopathy	62	77	5.99e-03
KEGG	KEGG:04144	Endocytosis	159	216	6.22e-03
KEGG	KEGG:04530	Tight junction	98	129	1.04e-02
KEGG	KEGG:04659	Th17 cell differentiation	49	60	1.07e-02
KEGG	KEGG:05207	Chemical carcinogenesis - receptor activation	100	132	1.07e-02
KEGG	KEGG:04919	Thyroid hormone signaling pathway	81	105	1.11e-02
KEGG	KEGG:04625	C-type lectin receptor signaling pathway	59	74	1.11e-02
KEGG	KEGG:04960	Aldosterone-regulated sodium reabsorption	22	24	1.11e-02
KEGG	KEGG:04912	GnRH signaling pathway	59	74	1.11e-02
KEGG	KEGG:04550	Signaling pathways regulating pluripotency of stem cells	78	101	1.19e-02
KEGG	KEGG:04660	T cell receptor signaling pathway	66	84	1.19e-02
KEGG	KEGG:05231	Choline metabolism in cancer	63	80	1.30e-02
KEGG	KEGG:05100	Bacterial invasion of epithelial cells	58	73	1.30e-02
KEGG	KEGG:04070	Phosphatidylinositol signaling system	65	83	1.41e-02
KEGG	KEGG:04514	Cell adhesion molecules	55	69	1.42e-02
KEGG	KEGG:04071	Sphingolipid signaling pathway	79	103	1.46e-02
KEGG	KEGG:03320	PPAR signaling pathway	39	47	1.49e-02
KEGG	KEGG:01521	EGFR tyrosine kinase inhibitor resistance	57	72	1.54e-02
KEGG	KEGG:05032	Morphine addiction	44	54	1.61e-02
KEGG	KEGG:04916	Melanogenesis	59	75	1.64e-02
KEGG	KEGG:04012	ErbB signaling pathway	59	75	1.64e-02
KEGG	KEGG:00564	Glycerophospholipid metabolism	56	71	1.84e-02
KEGG	KEGG:05170	Human immunodeficiency virus 1 infection	110	149	2.20e-02
KEGG	KEGG:04630	JAK-STAT signaling pathway	64	83	2.57e-02
KEGG	KEGG:05418	Fluid shear stress and atherosclerosis	82	109	2.68e-02
KEGG	KEGG:04062	Chemokine signaling pathway	82	109	2.68e-02
KEGG	KEGG:00512	Mucin type O-glycan biosynthesis	19	21	2.68e-02
KEGG	KEGG:05167	Kaposi sarcoma-associated herpesvirus infection	99	134	3.01e-02
KEGG	KEGG:05130	Pathogenic Escherichia coli infection	105	143	3.23e-02
KEGG	KEGG:05210	Colorectal cancer	62	81	3.50e-02
KEGG	KEGG:04722	Neurotrophin signaling pathway	78	104	3.50e-02
KEGG	KEGG:04742	Taste transduction	18	20	3.50e-02
KEGG	KEGG:04931	Insulin resistance	69	91	3.50e-02
KEGG	KEGG:04390	Hippo signaling pathway	95	129	3.79e-02
KEGG	KEGG:05165	Human papillomavirus infection	178	252	3.97e-02
KEGG	KEGG:01212	Fatty acid metabolism	37	46	4.08e-02
KEGG	KEGG:04068	FoxO signaling pathway	79	106	4.10e-02
KEGG	KEGG:00514	Other types of O-glycan biosynthesis	29	35	4.12e-02
KEGG	KEGG:04930	Type II diabetes mellitus	29	35	4.12e-02
KEGG	KEGG:00280	Valine, leucine and isoleucine degradation	34	42	4.33e-02
KEGG	KEGG:04664	Fc epsilon RI signaling pathway	34	42	4.33e-02
KEGG	KEGG:04723	Retrograde endocannabinoid signaling	69	92	4.64e-02
KEGG	KEGG:04380	Osteoclast differentiation	69	92	4.64e-02
KEGG	KEGG:01040	Biosynthesis of unsaturated fatty acids	20	23	4.64e-02
KEGG	KEGG:04727	GABAergic synapse	41	52	4.67e-02
KEGG	KEGG:04662	B cell receptor signaling pathway	41	52	4.67e-02
KEGG	KEGG:05031	Amphetamine addiction	36	45	4.68e-02
KEGG	KEGG:05131	Shigellosis	145	204	4.69e-02
KEGG	KEGG:04211	Longevity regulating pathway	57	75	4.95e-02
KEGG	KEGG:04152	AMPK signaling pathway	75	101	4.95e-02
KEGG	KEGG:04666	Fc gamma R-mediated phagocytosis	57	75	4.95e-02

LR peaks overlapping enhancers

# LR_resgenes_20k_enh <- gost(query = unique(LR_enh_peaks_20k$NCBI_gene),
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(LR_resgenes_20k_enh,"data/GO_KEGG_analysis/LR_resgenes_20k_enh.RDS")


# LRnom <- gostplot(LR_resgenes_20k_enh, capped = FALSE, interactive = TRUE)
# LRnom

LRnomtable_20k_enh <- LR_resgenes_20k_enh$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

LRnomtable_20k_enh %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in LR neargenes_20k" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in LR neargenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0050896	response to stimulus	1012	5379	1.25e-17
GO:BP	GO:0007154	cell communication	789	3983	1.25e-17
GO:BP	GO:0023052	signaling	778	3918	1.25e-17
GO:BP	GO:0048856	anatomical structure development	768	3867	2.10e-17
GO:BP	GO:0051239	regulation of multicellular organismal process	434	1924	4.48e-17
GO:BP	GO:0009653	anatomical structure morphogenesis	418	1844	9.43e-17
GO:BP	GO:0032501	multicellular organismal process	864	4504	3.39e-16
GO:BP	GO:0007165	signal transduction	718	3611	4.68e-16
GO:BP	GO:0007275	multicellular organism development	641	3170	2.41e-15
GO:BP	GO:0051716	cellular response to stimulus	878	4640	7.34e-15
GO:BP	GO:0032502	developmental process	803	4179	1.11e-14
GO:BP	GO:0030029	actin filament-based process	176	640	2.32e-13
GO:BP	GO:0072359	circulatory system development	220	864	4.21e-13
GO:BP	GO:0048731	system development	553	2719	4.37e-13
GO:BP	GO:0048519	negative regulation of biological process	725	3764	7.59e-13
GO:BP	GO:0048523	negative regulation of cellular process	690	3550	7.59e-13
GO:BP	GO:0007166	cell surface receptor signaling pathway	390	1801	2.55e-12
GO:BP	GO:0050789	regulation of biological process	1301	7516	3.24e-12
GO:BP	GO:0010646	regulation of cell communication	501	2444	3.51e-12
GO:BP	GO:0007155	cell adhesion	231	941	3.82e-12
GO:BP	GO:0048583	regulation of response to stimulus	547	2717	3.82e-12
GO:BP	GO:0048513	animal organ development	424	2004	4.73e-12
GO:BP	GO:0061061	muscle structure development	149	536	1.04e-11
GO:BP	GO:0023051	regulation of signaling	495	2438	2.67e-11
GO:BP	GO:0065007	biological regulation	1326	7734	3.75e-11
GO:BP	GO:0016477	cell migration	240	1011	4.70e-11
GO:BP	GO:0009966	regulation of signal transduction	446	2166	6.97e-11
GO:BP	GO:0031589	cell-substrate adhesion	86	258	8.53e-11
GO:BP	GO:0009888	tissue development	301	1348	8.79e-11
GO:BP	GO:0051146	striated muscle cell differentiation	79	234	3.46e-10
GO:BP	GO:0030154	cell differentiation	550	2803	3.46e-10
GO:BP	GO:0048869	cellular developmental process	550	2804	3.55e-10
GO:BP	GO:0010810	regulation of cell-substrate adhesion	61	162	6.44e-10
GO:BP	GO:0048870	cell motility	255	1120	7.91e-10
GO:BP	GO:0044057	regulation of system process	111	384	1.08e-09
GO:BP	GO:0030036	actin cytoskeleton organization	148	566	1.56e-09
GO:BP	GO:0050793	regulation of developmental process	357	1697	1.58e-09
GO:BP	GO:0048518	positive regulation of biological process	788	4301	2.69e-09
GO:BP	GO:0050794	regulation of cellular process	1227	7153	3.11e-09
GO:BP	GO:0003013	circulatory system process	118	426	4.29e-09
GO:BP	GO:0042692	muscle cell differentiation	96	323	4.89e-09
GO:BP	GO:0008015	blood circulation	103	357	6.19e-09
GO:BP	GO:0003012	muscle system process	96	325	6.85e-09
GO:BP	GO:0030155	regulation of cell adhesion	133	508	1.45e-08
GO:BP	GO:0040011	locomotion	190	805	2.19e-08
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	173	717	2.53e-08
GO:BP	GO:0048522	positive regulation of cellular process	725	3954	2.89e-08
GO:BP	GO:0060537	muscle tissue development	97	339	3.42e-08
GO:BP	GO:0001568	blood vessel development	135	525	3.51e-08
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	195	837	3.57e-08
GO:BP	GO:2000145	regulation of cell motility	169	700	3.62e-08
GO:BP	GO:0001944	vasculature development	140	552	4.20e-08
GO:BP	GO:0003008	system process	250	1139	4.52e-08
GO:BP	GO:0060047	heart contraction	64	194	8.25e-08
GO:BP	GO:0009968	negative regulation of signal transduction	218	972	9.89e-08
GO:BP	GO:0048585	negative regulation of response to stimulus	258	1193	9.89e-08
GO:BP	GO:0040012	regulation of locomotion	171	720	9.89e-08
GO:BP	GO:0030334	regulation of cell migration	161	668	1.01e-07
GO:BP	GO:0003015	heart process	66	204	1.02e-07
GO:BP	GO:0009987	cellular process	1718	10686	1.43e-07
GO:BP	GO:0006793	phosphorus metabolic process	381	1904	1.64e-07
GO:BP	GO:0006796	phosphate-containing compound metabolic process	377	1883	1.90e-07
GO:BP	GO:0035239	tube morphogenesis	154	638	2.01e-07
GO:BP	GO:0023057	negative regulation of signaling	228	1036	2.02e-07
GO:BP	GO:0090257	regulation of muscle system process	59	177	2.08e-07
GO:BP	GO:0048514	blood vessel morphogenesis	117	450	2.21e-07
GO:BP	GO:0014706	striated muscle tissue development	67	213	2.52e-07
GO:BP	GO:0071495	cellular response to endogenous stimulus	227	1035	2.86e-07
GO:BP	GO:0009719	response to endogenous stimulus	256	1197	2.95e-07
GO:BP	GO:0008150	biological_process	1789	11244	2.95e-07
GO:BP	GO:0035295	tube development	181	787	3.49e-07
GO:BP	GO:0006941	striated muscle contraction	51	146	3.97e-07
GO:BP	GO:0045595	regulation of cell differentiation	233	1073	3.97e-07
GO:BP	GO:0010648	negative regulation of cell communication	226	1034	3.97e-07
GO:BP	GO:0055001	muscle cell development	55	163	3.97e-07
GO:BP	GO:0051093	negative regulation of developmental process	149	622	5.42e-07
GO:BP	GO:0001667	ameboidal-type cell migration	94	344	5.59e-07
GO:BP	GO:0141124	intracellular signaling cassette	275	1314	5.84e-07
GO:BP	GO:0030048	actin filament-based movement	41	107	5.84e-07
GO:BP	GO:0060048	cardiac muscle contraction	43	116	7.97e-07
GO:BP	GO:0051094	positive regulation of developmental process	202	913	9.93e-07
GO:BP	GO:0032970	regulation of actin filament-based process	84	300	1.03e-06
GO:BP	GO:0001952	regulation of cell-matrix adhesion	36	90	1.26e-06
GO:BP	GO:0043502	regulation of muscle adaptation	30	68	1.40e-06
GO:BP	GO:0008016	regulation of heart contraction	54	165	1.61e-06
GO:BP	GO:0070252	actin-mediated cell contraction	35	87	1.62e-06
GO:BP	GO:0048738	cardiac muscle tissue development	62	201	1.79e-06
GO:BP	GO:0090130	tissue migration	72	247	1.82e-06
GO:BP	GO:0010631	epithelial cell migration	71	243	2.01e-06
GO:BP	GO:0090132	epithelium migration	71	243	2.01e-06
GO:BP	GO:0065008	regulation of biological quality	371	1893	2.51e-06
GO:BP	GO:0032879	regulation of localization	293	1439	2.57e-06
GO:BP	GO:1903522	regulation of blood circulation	60	194	2.57e-06
GO:BP	GO:0043500	muscle adaptation	35	89	2.96e-06
GO:BP	GO:0035556	intracellular signal transduction	380	1951	3.24e-06
GO:BP	GO:0007507	heart development	122	499	3.38e-06
GO:BP	GO:0007160	cell-matrix adhesion	54	169	3.55e-06
GO:BP	GO:0043542	endothelial cell migration	55	174	4.00e-06
GO:BP	GO:0048468	cell development	368	1886	4.48e-06
GO:BP	GO:0065009	regulation of molecular function	267	1299	4.64e-06
GO:BP	GO:0031032	actomyosin structure organization	57	184	4.89e-06
GO:BP	GO:0051049	regulation of transport	231	1098	5.92e-06
GO:BP	GO:0097435	supramolecular fiber organization	146	633	7.57e-06
GO:BP	GO:0009605	response to external stimulus	310	1559	9.93e-06
GO:BP	GO:0051241	negative regulation of multicellular organismal process	159	706	1.01e-05
GO:BP	GO:0001525	angiogenesis	97	381	1.05e-05
GO:BP	GO:0032409	regulation of transporter activity	48	148	1.09e-05
GO:BP	GO:0051128	regulation of cellular component organization	361	1862	1.17e-05
GO:BP	GO:0055006	cardiac cell development	31	78	1.17e-05
GO:BP	GO:0086001	cardiac muscle cell action potential	27	63	1.18e-05
GO:BP	GO:0007162	negative regulation of cell adhesion	56	185	1.39e-05
GO:BP	GO:0150115	cell-substrate junction organization	35	95	1.68e-05
GO:BP	GO:0055013	cardiac muscle cell development	29	72	2.03e-05
GO:BP	GO:0010959	regulation of metal ion transport	67	239	2.22e-05
GO:BP	GO:0051240	positive regulation of multicellular organismal process	217	1040	2.67e-05
GO:BP	GO:0034330	cell junction organization	127	545	2.67e-05
GO:BP	GO:0055007	cardiac muscle cell differentiation	37	105	2.70e-05
GO:BP	GO:0009611	response to wounding	95	382	4.06e-05
GO:BP	GO:0010243	response to organonitrogen compound	152	685	4.46e-05
GO:BP	GO:0042127	regulation of cell population proliferation	222	1077	4.88e-05
GO:BP	GO:0034762	regulation of transmembrane transport	78	298	4.92e-05
GO:BP	GO:0007010	cytoskeleton organization	234	1146	4.98e-05
GO:BP	GO:0042221	response to chemical	430	2304	5.06e-05
GO:BP	GO:0098657	import into cell	140	622	5.25e-05
GO:BP	GO:0010632	regulation of epithelial cell migration	55	188	5.37e-05
GO:BP	GO:0150116	regulation of cell-substrate junction organization	25	60	5.67e-05
GO:BP	GO:0086003	cardiac muscle cell contraction	26	64	6.13e-05
GO:BP	GO:0009887	animal organ morphogenesis	149	673	6.19e-05
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	70	261	6.57e-05
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	137	609	6.82e-05
GO:BP	GO:0097553	calcium ion transmembrane import into cytosol	40	122	7.12e-05
GO:BP	GO:0030198	extracellular matrix organization	62	223	7.19e-05
GO:BP	GO:0043269	regulation of monoatomic ion transport	74	282	7.77e-05
GO:BP	GO:0043062	extracellular structure organization	62	224	8.30e-05
GO:BP	GO:0045229	external encapsulating structure organization	62	224	8.30e-05
GO:BP	GO:0061337	cardiac conduction	31	85	8.66e-05
GO:BP	GO:0014902	myotube differentiation	31	85	8.66e-05
GO:BP	GO:0008283	cell population proliferation	260	1306	8.68e-05
GO:BP	GO:0045596	negative regulation of cell differentiation	107	452	8.70e-05
GO:BP	GO:0035051	cardiocyte differentiation	42	132	8.87e-05
GO:BP	GO:0002040	sprouting angiogenesis	34	98	9.96e-05
GO:BP	GO:0006936	muscle contraction	68	255	1.06e-04
GO:BP	GO:0051283	negative regulation of sequestering of calcium ion	32	90	1.07e-04
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	54	188	1.10e-04
GO:BP	GO:0009725	response to hormone	136	610	1.12e-04
GO:BP	GO:0007015	actin filament organization	88	357	1.27e-04
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	107	456	1.28e-04
GO:BP	GO:2000026	regulation of multicellular organismal development	197	951	1.28e-04
GO:BP	GO:0030038	contractile actin filament bundle assembly	32	91	1.35e-04
GO:BP	GO:0043149	stress fiber assembly	32	91	1.35e-04
GO:BP	GO:0007517	muscle organ development	70	267	1.37e-04
GO:BP	GO:0042391	regulation of membrane potential	73	282	1.38e-04
GO:BP	GO:0022898	regulation of transmembrane transporter activity	43	139	1.41e-04
GO:BP	GO:0051336	regulation of hydrolase activity	102	431	1.41e-04
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	66	248	1.49e-04
GO:BP	GO:1900024	regulation of substrate adhesion-dependent cell spreading	22	52	1.54e-04
GO:BP	GO:0043534	blood vessel endothelial cell migration	32	92	1.67e-04
GO:BP	GO:0051282	regulation of sequestering of calcium ion	32	92	1.67e-04
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	58	210	1.67e-04
GO:BP	GO:0016310	phosphorylation	230	1145	1.71e-04
GO:BP	GO:0007044	cell-substrate junction assembly	31	88	1.73e-04
GO:BP	GO:0071310	cellular response to organic substance	256	1297	1.80e-04
GO:BP	GO:0043270	positive regulation of monoatomic ion transport	40	127	1.80e-04
GO:BP	GO:0010594	regulation of endothelial cell migration	42	136	1.80e-04
GO:BP	GO:0045597	positive regulation of cell differentiation	131	591	2.11e-04
GO:BP	GO:0110053	regulation of actin filament organization	58	212	2.19e-04
GO:BP	GO:0051209	release of sequestered calcium ion into cytosol	31	89	2.19e-04
GO:BP	GO:0051899	membrane depolarization	23	57	2.26e-04
GO:BP	GO:0006942	regulation of striated muscle contraction	29	81	2.35e-04
GO:BP	GO:0048041	focal adhesion assembly	28	77	2.40e-04
GO:BP	GO:0006816	calcium ion transport	68	262	2.45e-04
GO:BP	GO:0040013	negative regulation of locomotion	64	243	2.75e-04
GO:BP	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	41	134	2.88e-04
GO:BP	GO:0086065	cell communication involved in cardiac conduction	22	54	2.92e-04
GO:BP	GO:0071559	response to transforming growth factor beta	59	219	2.92e-04
GO:BP	GO:0002028	regulation of sodium ion transport	23	58	3.06e-04
GO:BP	GO:0070887	cellular response to chemical stimulus	331	1751	3.13e-04
GO:BP	GO:0070588	calcium ion transmembrane transport	57	210	3.22e-04
GO:BP	GO:0010811	positive regulation of cell-substrate adhesion	32	95	3.23e-04
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	58	215	3.25e-04
GO:BP	GO:0000902	cell morphogenesis	152	713	3.30e-04
GO:BP	GO:0098655	monoatomic cation transmembrane transport	112	495	3.67e-04
GO:BP	GO:1901652	response to peptide	88	368	3.75e-04
GO:BP	GO:0002027	regulation of heart rate	29	83	3.75e-04
GO:BP	GO:0071417	cellular response to organonitrogen compound	102	442	3.80e-04
GO:BP	GO:0071363	cellular response to growth factor stimulus	118	528	3.80e-04
GO:BP	GO:0090109	regulation of cell-substrate junction assembly	22	55	3.86e-04
GO:BP	GO:0051893	regulation of focal adhesion assembly	22	55	3.86e-04
GO:BP	GO:0051235	maintenance of location	65	251	3.87e-04
GO:BP	GO:0051208	sequestering of calcium ion	32	96	3.90e-04
GO:BP	GO:0098662	inorganic cation transmembrane transport	109	480	3.90e-04
GO:BP	GO:0030335	positive regulation of cell migration	93	395	3.92e-04
GO:BP	GO:0010634	positive regulation of epithelial cell migration	39	127	3.94e-04
GO:BP	GO:0006897	endocytosis	111	492	4.32e-04
GO:BP	GO:1901700	response to oxygen-containing compound	218	1093	4.32e-04
GO:BP	GO:1902305	regulation of sodium ion transmembrane transport	17	37	4.41e-04
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	61	233	4.85e-04
GO:BP	GO:2000147	positive regulation of cell motility	95	408	4.92e-04
GO:BP	GO:1901698	response to nitrogen compound	155	736	4.92e-04
GO:BP	GO:1902903	regulation of supramolecular fiber organization	75	304	5.04e-04
GO:BP	GO:0010812	negative regulation of cell-substrate adhesion	18	41	5.16e-04
GO:BP	GO:0086010	membrane depolarization during action potential	13	24	5.16e-04
GO:BP	GO:0046486	glycerolipid metabolic process	71	284	5.24e-04
GO:BP	GO:0001508	action potential	33	102	5.41e-04
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	99	431	5.69e-04
GO:BP	GO:0032231	regulation of actin filament bundle assembly	29	85	5.69e-04
GO:BP	GO:0061448	connective tissue development	55	205	5.78e-04
GO:BP	GO:0051492	regulation of stress fiber assembly	27	77	6.23e-04
GO:BP	GO:1903053	regulation of extracellular matrix organization	20	49	6.23e-04
GO:BP	GO:0040017	positive regulation of locomotion	96	416	6.23e-04
GO:BP	GO:0010644	cell communication by electrical coupling	15	31	6.29e-04
GO:BP	GO:0070296	sarcoplasmic reticulum calcium ion transport	15	31	6.29e-04
GO:BP	GO:0051924	regulation of calcium ion transport	44	153	6.33e-04
GO:BP	GO:0006470	protein dephosphorylation	49	177	6.61e-04
GO:BP	GO:0032870	cellular response to hormone stimulus	99	433	6.68e-04
GO:BP	GO:0070848	response to growth factor	120	547	6.85e-04
GO:BP	GO:1902531	regulation of intracellular signal transduction	250	1289	6.88e-04
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	308	1633	6.95e-04
GO:BP	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	14	28	7.29e-04
GO:BP	GO:1903514	release of sequestered calcium ion into cytosol by endoplasmic reticulum	14	28	7.29e-04
GO:BP	GO:0010033	response to organic substance	325	1736	7.30e-04
GO:BP	GO:2000146	negative regulation of cell motility	57	217	7.46e-04
GO:BP	GO:0098660	inorganic ion transmembrane transport	115	521	7.47e-04
GO:BP	GO:0010762	regulation of fibroblast migration	16	35	7.65e-04
GO:BP	GO:0051050	positive regulation of transport	124	571	7.86e-04
GO:BP	GO:0043434	response to peptide hormone	76	314	8.03e-04
GO:BP	GO:0007399	nervous system development	331	1775	8.22e-04
GO:BP	GO:0051248	negative regulation of protein metabolic process	130	605	8.35e-04
GO:BP	GO:0034446	substrate adhesion-dependent cell spreading	29	87	8.44e-04
GO:BP	GO:0110020	regulation of actomyosin structure organization	29	87	8.44e-04
GO:BP	GO:0006810	transport	528	2984	8.99e-04
GO:BP	GO:0019722	calcium-mediated signaling	37	123	9.22e-04
GO:BP	GO:0001935	endothelial cell proliferation	35	114	9.31e-04
GO:BP	GO:0030001	metal ion transport	115	524	9.31e-04
GO:BP	GO:0016043	cellular component organization	815	4802	1.00e-03
GO:BP	GO:0040007	growth	146	697	1.00e-03
GO:BP	GO:0045785	positive regulation of cell adhesion	73	301	1.03e-03
GO:BP	GO:0051928	positive regulation of calcium ion transport	25	71	1.04e-03
GO:BP	GO:2001257	regulation of cation channel activity	24	67	1.08e-03
GO:BP	GO:0010595	positive regulation of endothelial cell migration	29	89	1.31e-03
GO:BP	GO:1903055	positive regulation of extracellular matrix organization	13	26	1.32e-03
GO:BP	GO:0048384	retinoic acid receptor signaling pathway	13	26	1.32e-03
GO:BP	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	13	26	1.32e-03
GO:BP	GO:0008285	negative regulation of cell population proliferation	104	469	1.40e-03
GO:BP	GO:0019220	regulation of phosphate metabolic process	164	804	1.40e-03
GO:BP	GO:1904064	positive regulation of cation transmembrane transport	27	81	1.49e-03
GO:BP	GO:0051174	regulation of phosphorus metabolic process	164	805	1.49e-03
GO:BP	GO:0006650	glycerophospholipid metabolic process	58	228	1.55e-03
GO:BP	GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	9	14	1.59e-03
GO:BP	GO:0051017	actin filament bundle assembly	38	131	1.64e-03
GO:BP	GO:0044092	negative regulation of molecular function	110	504	1.66e-03
GO:BP	GO:0010649	regulation of cell communication by electrical coupling	10	17	1.71e-03
GO:BP	GO:1902105	regulation of leukocyte differentiation	51	194	1.73e-03
GO:BP	GO:0006468	protein phosphorylation	190	958	1.83e-03
GO:BP	GO:0042060	wound healing	70	291	1.84e-03
GO:BP	GO:0061572	actin filament bundle organization	38	132	1.92e-03
GO:BP	GO:0043010	camera-type eye development	58	230	1.95e-03
GO:BP	GO:1901699	cellular response to nitrogen compound	105	479	1.99e-03
GO:BP	GO:0051130	positive regulation of cellular component organization	171	850	1.99e-03
GO:BP	GO:0002521	leukocyte differentiation	85	371	2.00e-03
GO:BP	GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	36	123	2.00e-03
GO:BP	GO:1990778	protein localization to cell periphery	69	287	2.06e-03
GO:BP	GO:0007179	transforming growth factor beta receptor signaling pathway	46	171	2.10e-03
GO:BP	GO:0048584	positive regulation of response to stimulus	282	1504	2.18e-03
GO:BP	GO:0044093	positive regulation of molecular function	159	783	2.18e-03
GO:BP	GO:0006950	response to stress	452	2540	2.26e-03
GO:BP	GO:0006812	monoatomic cation transport	129	614	2.28e-03
GO:BP	GO:0001954	positive regulation of cell-matrix adhesion	17	42	2.40e-03
GO:BP	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	12	24	2.40e-03
GO:BP	GO:0002761	regulation of myeloid leukocyte differentiation	26	79	2.41e-03
GO:BP	GO:0016311	dephosphorylation	58	232	2.41e-03
GO:BP	GO:0034220	monoatomic ion transmembrane transport	124	587	2.41e-03
GO:BP	GO:0022008	neurogenesis	239	1251	2.43e-03
GO:BP	GO:0001654	eye development	64	263	2.46e-03
GO:BP	GO:0001501	skeletal system development	80	347	2.48e-03
GO:BP	GO:0002062	chondrocyte differentiation	28	88	2.49e-03
GO:BP	GO:0048660	regulation of smooth muscle cell proliferation	30	97	2.51e-03
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	68	284	2.51e-03
GO:BP	GO:0006915	apoptotic process	260	1377	2.55e-03
GO:BP	GO:0045655	regulation of monocyte differentiation	8	12	2.66e-03
GO:BP	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading	8	12	2.66e-03
GO:BP	GO:0043535	regulation of blood vessel endothelial cell migration	24	71	2.67e-03
GO:BP	GO:0086012	membrane depolarization during cardiac muscle cell action potential	11	21	2.67e-03
GO:BP	GO:0150063	visual system development	64	264	2.68e-03
GO:BP	GO:0048592	eye morphogenesis	32	107	2.95e-03
GO:BP	GO:1990845	adaptive thermogenesis	35	121	2.98e-03
GO:BP	GO:1905709	negative regulation of membrane permeability	9	15	2.98e-03
GO:BP	GO:0050790	regulation of catalytic activity	177	893	3.06e-03
GO:BP	GO:0051279	regulation of release of sequestered calcium ion into cytosol	21	59	3.09e-03
GO:BP	GO:0051216	cartilage development	40	145	3.10e-03
GO:BP	GO:0006937	regulation of muscle contraction	36	126	3.11e-03
GO:BP	GO:0006629	lipid metabolic process	182	923	3.21e-03
GO:BP	GO:0048880	sensory system development	64	266	3.28e-03
GO:BP	GO:0098609	cell-cell adhesion	119	564	3.28e-03
GO:BP	GO:0051346	negative regulation of hydrolase activity	34	117	3.28e-03
GO:BP	GO:0009967	positive regulation of signal transduction	211	1093	3.29e-03
GO:BP	GO:0060284	regulation of cell development	120	570	3.35e-03
GO:BP	GO:0030336	negative regulation of cell migration	53	210	3.38e-03
GO:BP	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	35	122	3.43e-03
GO:BP	GO:0032989	cellular anatomical entity morphogenesis	123	588	3.64e-03
GO:BP	GO:0048771	tissue remodeling	33	113	3.64e-03
GO:BP	GO:0000768	syncytium formation by plasma membrane fusion	15	36	3.80e-03
GO:BP	GO:0140253	cell-cell fusion	15	36	3.80e-03
GO:BP	GO:0085029	extracellular matrix assembly	15	36	3.80e-03
GO:BP	GO:1902893	regulation of miRNA transcription	21	60	3.85e-03
GO:BP	GO:0007229	integrin-mediated signaling pathway	27	86	3.85e-03
GO:BP	GO:0035725	sodium ion transmembrane transport	29	95	3.85e-03
GO:BP	GO:0051179	localization	639	3731	4.07e-03
GO:BP	GO:0033002	muscle cell proliferation	41	152	4.11e-03
GO:BP	GO:0030097	hemopoiesis	129	624	4.12e-03
GO:BP	GO:0051234	establishment of localization	561	3240	4.12e-03
GO:BP	GO:0086002	cardiac muscle cell action potential involved in contraction	17	44	4.12e-03
GO:BP	GO:0050673	epithelial cell proliferation	70	300	4.12e-03
GO:BP	GO:0034767	positive regulation of monoatomic ion transmembrane transport	28	91	4.20e-03
GO:BP	GO:0007520	myoblast fusion	13	29	4.22e-03
GO:BP	GO:2000649	regulation of sodium ion transmembrane transporter activity	13	29	4.22e-03
GO:BP	GO:0150117	positive regulation of cell-substrate junction organization	13	29	4.22e-03
GO:BP	GO:0036293	response to decreased oxygen levels	59	243	4.25e-03
GO:BP	GO:1901701	cellular response to oxygen-containing compound	159	796	4.26e-03
GO:BP	GO:0010647	positive regulation of cell communication	231	1218	4.41e-03
GO:BP	GO:0048593	camera-type eye morphogenesis	27	87	4.57e-03
GO:BP	GO:0002376	immune system process	263	1410	4.67e-03
GO:BP	GO:0022604	regulation of cell morphogenesis	49	193	4.76e-03
GO:BP	GO:0061614	miRNA transcription	21	61	4.76e-03
GO:BP	GO:0070482	response to oxygen levels	63	265	4.78e-03
GO:BP	GO:0042592	homeostatic process	217	1137	4.78e-03
GO:BP	GO:0014897	striated muscle hypertrophy	24	74	4.80e-03
GO:BP	GO:0048659	smooth muscle cell proliferation	30	101	4.80e-03
GO:BP	GO:1901184	regulation of ERBB signaling pathway	20	57	4.95e-03
GO:BP	GO:0023056	positive regulation of signaling	231	1221	4.99e-03
GO:BP	GO:0014874	response to stimulus involved in regulation of muscle adaptation	8	13	5.08e-03
GO:BP	GO:0008360	regulation of cell shape	31	106	5.08e-03
GO:BP	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	12	26	5.14e-03
GO:BP	GO:0012501	programmed cell death	264	1419	5.20e-03
GO:BP	GO:0008610	lipid biosynthetic process	111	527	5.24e-03
GO:BP	GO:0045765	regulation of angiogenesis	49	194	5.25e-03
GO:BP	GO:0043536	positive regulation of blood vessel endothelial cell migration	17	45	5.25e-03
GO:BP	GO:0009892	negative regulation of metabolic process	376	2100	5.37e-03
GO:BP	GO:0030030	cell projection organization	224	1182	5.54e-03
GO:BP	GO:0007264	small GTPase-mediated signal transduction	86	390	5.64e-03
GO:BP	GO:0051493	regulation of cytoskeleton organization	90	412	5.70e-03
GO:BP	GO:0014896	muscle hypertrophy	24	75	5.80e-03
GO:BP	GO:0071375	cellular response to peptide hormone stimulus	56	231	5.97e-03
GO:BP	GO:1903706	regulation of hemopoiesis	61	257	5.97e-03
GO:BP	GO:0008219	cell death	264	1423	6.07e-03
GO:BP	GO:1901653	cellular response to peptide	64	273	6.11e-03
GO:BP	GO:0030224	monocyte differentiation	11	23	6.15e-03
GO:BP	GO:1902894	negative regulation of miRNA transcription	11	23	6.15e-03
GO:BP	GO:0006644	phospholipid metabolic process	67	289	6.15e-03
GO:BP	GO:0002026	regulation of the force of heart contraction	11	23	6.15e-03
GO:BP	GO:0009790	embryo development	162	821	6.25e-03
GO:BP	GO:1901019	regulation of calcium ion transmembrane transporter activity	18	50	6.67e-03
GO:BP	GO:0051651	maintenance of location in cell	44	171	6.68e-03
GO:BP	GO:0045668	negative regulation of osteoblast differentiation	15	38	6.69e-03
GO:BP	GO:0006949	syncytium formation	15	38	6.69e-03
GO:BP	GO:0035265	organ growth	35	127	6.82e-03
GO:BP	GO:1903169	regulation of calcium ion transmembrane transport	31	108	6.83e-03
GO:BP	GO:0014894	response to denervation involved in regulation of muscle adaptation	6	8	6.83e-03
GO:BP	GO:0014877	response to muscle inactivity involved in regulation of muscle adaptation	6	8	6.83e-03
GO:BP	GO:0006811	monoatomic ion transport	144	719	6.85e-03
GO:BP	GO:0016192	vesicle-mediated transport	218	1152	6.92e-03
GO:BP	GO:0009893	positive regulation of metabolic process	459	2622	7.03e-03
GO:BP	GO:0032411	positive regulation of transporter activity	21	63	7.08e-03
GO:BP	GO:0001558	regulation of cell growth	73	323	7.21e-03
GO:BP	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process	10	20	7.22e-03
GO:BP	GO:1901021	positive regulation of calcium ion transmembrane transporter activity	12	27	7.25e-03
GO:BP	GO:0051129	negative regulation of cellular component organization	115	555	7.26e-03
GO:BP	GO:0038127	ERBB signaling pathway	30	104	7.53e-03
GO:BP	GO:0048878	chemical homeostasis	135	670	7.93e-03
GO:BP	GO:0090559	regulation of membrane permeability	19	55	7.98e-03
GO:BP	GO:1901342	regulation of vasculature development	49	198	7.98e-03
GO:BP	GO:0008154	actin polymerization or depolymerization	39	148	8.26e-03
GO:BP	GO:0090596	sensory organ morphogenesis	44	173	8.32e-03
GO:BP	GO:0019637	organophosphate metabolic process	152	769	8.41e-03
GO:BP	GO:0040008	regulation of growth	98	462	8.42e-03
GO:BP	GO:0014743	regulation of muscle hypertrophy	17	47	8.62e-03
GO:BP	GO:0030010	establishment of cell polarity	34	124	8.68e-03
GO:BP	GO:0003300	cardiac muscle hypertrophy	23	73	9.07e-03
GO:BP	GO:0048661	positive regulation of smooth muscle cell proliferation	20	60	9.37e-03
GO:BP	GO:0001936	regulation of endothelial cell proliferation	28	96	9.37e-03
GO:BP	GO:1903708	positive regulation of hemopoiesis	32	115	9.45e-03
GO:BP	GO:1902107	positive regulation of leukocyte differentiation	32	115	9.45e-03
GO:BP	GO:0098771	inorganic ion homeostasis	77	348	9.45e-03
GO:BP	GO:1990849	vacuolar localization	19	56	9.96e-03
GO:BP	GO:0032418	lysosome localization	19	56	9.96e-03
GO:BP	GO:1902904	negative regulation of supramolecular fiber organization	34	125	9.96e-03
GO:BP	GO:0034764	positive regulation of transmembrane transport	35	130	1.02e-02
GO:BP	GO:1903670	regulation of sprouting angiogenesis	12	28	1.03e-02
GO:BP	GO:0055074	calcium ion homeostasis	52	216	1.04e-02
GO:BP	GO:1904427	positive regulation of calcium ion transmembrane transport	18	52	1.05e-02
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	216	1150	1.05e-02
GO:BP	GO:0055117	regulation of cardiac muscle contraction	21	65	1.06e-02
GO:BP	GO:0001666	response to hypoxia	55	232	1.07e-02
GO:BP	GO:0009991	response to extracellular stimulus	82	377	1.07e-02
GO:BP	GO:0045834	positive regulation of lipid metabolic process	25	83	1.07e-02
GO:BP	GO:0032787	monocarboxylic acid metabolic process	89	416	1.10e-02
GO:BP	GO:0071840	cellular component organization or biogenesis	829	4988	1.13e-02
GO:BP	GO:0044255	cellular lipid metabolic process	138	694	1.13e-02
GO:BP	GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	60	259	1.13e-02
GO:BP	GO:0003254	regulation of membrane depolarization	14	36	1.13e-02
GO:BP	GO:0072659	protein localization to plasma membrane	56	238	1.14e-02
GO:BP	GO:0045165	cell fate commitment	39	151	1.18e-02
GO:BP	GO:0003205	cardiac chamber development	39	151	1.18e-02
GO:BP	GO:0048589	developmental growth	104	501	1.18e-02
GO:BP	GO:0007267	cell-cell signaling	204	1082	1.20e-02
GO:BP	GO:0106106	cold-induced thermogenesis	31	112	1.21e-02
GO:BP	GO:1903589	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	4	4	1.22e-02
GO:BP	GO:0008064	regulation of actin polymerization or depolymerization	32	117	1.24e-02
GO:BP	GO:0051494	negative regulation of cytoskeleton organization	34	127	1.29e-02
GO:BP	GO:2000629	negative regulation of miRNA metabolic process	11	25	1.29e-02
GO:BP	GO:0006658	phosphatidylserine metabolic process	9	18	1.29e-02
GO:BP	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	9	18	1.29e-02
GO:BP	GO:0060402	calcium ion transport into cytosol	9	18	1.29e-02
GO:BP	GO:0043304	regulation of mast cell degranulation	9	18	1.29e-02
GO:BP	GO:0010743	regulation of macrophage derived foam cell differentiation	9	18	1.29e-02
GO:BP	GO:0006814	sodium ion transport	36	137	1.30e-02
GO:BP	GO:0042981	regulation of apoptotic process	195	1031	1.31e-02
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	347	1951	1.34e-02
GO:BP	GO:0032233	positive regulation of actin filament bundle assembly	17	49	1.35e-02
GO:BP	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	24	80	1.37e-02
GO:BP	GO:0086005	ventricular cardiac muscle cell action potential	12	29	1.39e-02
GO:BP	GO:0006096	glycolytic process	22	71	1.39e-02
GO:BP	GO:0031324	negative regulation of cellular metabolic process	344	1934	1.39e-02
GO:BP	GO:0030832	regulation of actin filament length	32	118	1.40e-02
GO:BP	GO:0031667	response to nutrient levels	77	354	1.45e-02
GO:BP	GO:1903131	mononuclear cell differentiation	63	278	1.45e-02
GO:BP	GO:0006909	phagocytosis	36	138	1.46e-02
GO:BP	GO:0032414	positive regulation of ion transmembrane transporter activity	19	58	1.47e-02
GO:BP	GO:0010563	negative regulation of phosphorus metabolic process	65	289	1.47e-02
GO:BP	GO:0016049	cell growth	82	382	1.48e-02
GO:BP	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	6	9	1.48e-02
GO:BP	GO:0014745	negative regulation of muscle adaptation	6	9	1.48e-02
GO:BP	GO:0043306	positive regulation of mast cell degranulation	6	9	1.48e-02
GO:BP	GO:0014870	response to muscle inactivity	6	9	1.48e-02
GO:BP	GO:0019222	regulation of metabolic process	767	4603	1.52e-02
GO:BP	GO:0007266	Rho protein signal transduction	30	109	1.52e-02
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	50	210	1.54e-02
GO:BP	GO:0051246	regulation of protein metabolic process	288	1595	1.55e-02
GO:BP	GO:0071871	response to epinephrine	7	12	1.56e-02
GO:BP	GO:0034329	cell junction assembly	71	323	1.64e-02
GO:BP	GO:2000628	regulation of miRNA metabolic process	22	72	1.65e-02
GO:BP	GO:0010761	fibroblast migration	17	50	1.67e-02
GO:BP	GO:0048008	platelet-derived growth factor receptor signaling pathway	17	50	1.67e-02
GO:BP	GO:0001775	cell activation	125	627	1.67e-02
GO:BP	GO:0009179	purine ribonucleoside diphosphate metabolic process	25	86	1.68e-02
GO:BP	GO:0009135	purine nucleoside diphosphate metabolic process	25	86	1.68e-02
GO:BP	GO:0007173	epidermal growth factor receptor signaling pathway	25	86	1.68e-02
GO:BP	GO:1905952	regulation of lipid localization	30	110	1.74e-02
GO:BP	GO:0046902	regulation of mitochondrial membrane permeability	16	46	1.75e-02
GO:BP	GO:0050654	chondroitin sulfate proteoglycan metabolic process	11	26	1.75e-02
GO:BP	GO:0071407	cellular response to organic cyclic compound	81	379	1.75e-02
GO:BP	GO:0010611	regulation of cardiac muscle hypertrophy	16	46	1.75e-02
GO:BP	GO:0045637	regulation of myeloid cell differentiation	35	135	1.82e-02
GO:BP	GO:0031529	ruffle organization	15	42	1.82e-02
GO:BP	GO:0060627	regulation of vesicle-mediated transport	80	374	1.82e-02
GO:BP	GO:0086009	membrane repolarization	15	42	1.82e-02
GO:BP	GO:0030099	myeloid cell differentiation	65	292	1.83e-02
GO:BP	GO:0001974	blood vessel remodeling	12	30	1.85e-02
GO:BP	GO:0098900	regulation of action potential	14	38	1.87e-02
GO:BP	GO:0044087	regulation of cellular component biogenesis	147	757	1.87e-02
GO:BP	GO:0010662	regulation of striated muscle cell apoptotic process	13	34	1.88e-02
GO:BP	GO:1901201	regulation of extracellular matrix assembly	9	19	1.90e-02
GO:BP	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	9	19	1.90e-02
GO:BP	GO:0006874	intracellular calcium ion homeostasis	48	202	1.91e-02
GO:BP	GO:0045017	glycerolipid biosynthetic process	48	202	1.91e-02
GO:BP	GO:0046032	ADP catabolic process	22	73	1.91e-02
GO:BP	GO:0120161	regulation of cold-induced thermogenesis	30	111	1.95e-02
GO:BP	GO:0009628	response to abiotic stimulus	156	811	1.98e-02
GO:BP	GO:0042325	regulation of phosphorylation	134	683	2.02e-02
GO:BP	GO:0043067	regulation of programmed cell death	198	1060	2.02e-02
GO:BP	GO:0045936	negative regulation of phosphate metabolic process	64	288	2.03e-02
GO:BP	GO:0007423	sensory organ development	82	387	2.04e-02
GO:BP	GO:0046031	ADP metabolic process	23	78	2.04e-02
GO:BP	GO:0120162	positive regulation of cold-induced thermogenesis	21	69	2.11e-02
GO:BP	GO:0014909	smooth muscle cell migration	19	60	2.11e-02
GO:BP	GO:0030833	regulation of actin filament polymerization	28	102	2.15e-02
GO:BP	GO:0034763	negative regulation of transmembrane transport	24	83	2.15e-02
GO:BP	GO:0003416	endochondral bone growth	10	23	2.19e-02
GO:BP	GO:0010765	positive regulation of sodium ion transport	10	23	2.19e-02
GO:BP	GO:0030162	regulation of proteolysis	87	416	2.19e-02
GO:BP	GO:0002573	myeloid leukocyte differentiation	38	152	2.24e-02
GO:BP	GO:0019725	cellular homeostasis	113	564	2.25e-02
GO:BP	GO:0051496	positive regulation of stress fiber assembly	15	43	2.27e-02
GO:BP	GO:0032272	negative regulation of protein polymerization	20	65	2.31e-02
GO:BP	GO:0035023	regulation of Rho protein signal transduction	20	65	2.31e-02
GO:BP	GO:0048699	generation of neurons	200	1076	2.36e-02
GO:BP	GO:0062012	regulation of small molecule metabolic process	53	231	2.42e-02
GO:BP	GO:0045657	positive regulation of monocyte differentiation	5	7	2.49e-02
GO:BP	GO:0002064	epithelial cell development	37	148	2.54e-02
GO:BP	GO:0031399	regulation of protein modification process	172	911	2.54e-02
GO:BP	GO:0007584	response to nutrient	30	113	2.54e-02
GO:BP	GO:1905475	regulation of protein localization to membrane	36	143	2.54e-02
GO:BP	GO:1902905	positive regulation of supramolecular fiber organization	35	138	2.56e-02
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	181	965	2.59e-02
GO:BP	GO:0035795	negative regulation of mitochondrial membrane permeability	7	13	2.61e-02
GO:BP	GO:0043066	negative regulation of apoptotic process	122	619	2.65e-02
GO:BP	GO:0009137	purine nucleoside diphosphate catabolic process	22	75	2.65e-02
GO:BP	GO:0019364	pyridine nucleotide catabolic process	22	75	2.65e-02
GO:BP	GO:0009181	purine ribonucleoside diphosphate catabolic process	22	75	2.65e-02
GO:BP	GO:0006082	organic acid metabolic process	123	625	2.68e-02
GO:BP	GO:0071872	cellular response to epinephrine stimulus	6	10	2.76e-02
GO:BP	GO:0032530	regulation of microvillus organization	6	10	2.76e-02
GO:BP	GO:0033275	actin-myosin filament sliding	6	10	2.76e-02
GO:BP	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	9	20	2.76e-02
GO:BP	GO:1903671	negative regulation of sprouting angiogenesis	6	10	2.76e-02
GO:BP	GO:0031099	regeneration	36	144	2.81e-02
GO:BP	GO:0070613	regulation of protein processing	15	44	2.81e-02
GO:BP	GO:0050678	regulation of epithelial cell proliferation	56	249	2.81e-02
GO:BP	GO:0002042	cell migration involved in sprouting angiogenesis	15	44	2.81e-02
GO:BP	GO:0010876	lipid localization	65	298	2.82e-02
GO:BP	GO:0043086	negative regulation of catalytic activity	65	298	2.82e-02
GO:BP	GO:0030041	actin filament polymerization	32	124	2.84e-02
GO:BP	GO:0043409	negative regulation of MAPK cascade	32	124	2.84e-02
GO:BP	GO:0007519	skeletal muscle tissue development	31	119	2.84e-02
GO:BP	GO:0010717	regulation of epithelial to mesenchymal transition	24	85	2.86e-02
GO:BP	GO:0032271	regulation of protein polymerization	39	160	3.00e-02
GO:BP	GO:0045923	positive regulation of fatty acid metabolic process	10	24	3.01e-02
GO:BP	GO:0098868	bone growth	10	24	3.01e-02
GO:BP	GO:0002763	positive regulation of myeloid leukocyte differentiation	13	36	3.06e-02
GO:BP	GO:0048662	negative regulation of smooth muscle cell proliferation	13	36	3.06e-02
GO:BP	GO:2001259	positive regulation of cation channel activity	13	36	3.06e-02
GO:BP	GO:0006869	lipid transport	58	261	3.06e-02
GO:BP	GO:0060429	epithelium development	151	792	3.09e-02
GO:BP	GO:0050878	regulation of body fluid levels	52	229	3.15e-02
GO:BP	GO:0003206	cardiac chamber morphogenesis	29	110	3.17e-02
GO:BP	GO:0071805	potassium ion transmembrane transport	31	120	3.20e-02
GO:BP	GO:1904705	regulation of vascular associated smooth muscle cell proliferation	16	49	3.21e-02
GO:BP	GO:0022407	regulation of cell-cell adhesion	61	278	3.23e-02
GO:BP	GO:0014070	response to organic cyclic compound	119	606	3.24e-02
GO:BP	GO:0019752	carboxylic acid metabolic process	119	606	3.24e-02
GO:BP	GO:0048844	artery morphogenesis	18	58	3.27e-02
GO:BP	GO:0010955	negative regulation of protein processing	8	17	3.34e-02
GO:BP	GO:0030206	chondroitin sulfate biosynthetic process	8	17	3.34e-02
GO:BP	GO:1903318	negative regulation of protein maturation	8	17	3.34e-02
GO:BP	GO:0034383	low-density lipoprotein particle clearance	8	17	3.34e-02
GO:BP	GO:0006090	pyruvate metabolic process	25	91	3.38e-02
GO:BP	GO:0055080	monoatomic cation homeostasis	83	401	3.41e-02
GO:BP	GO:0001932	regulation of protein phosphorylation	125	642	3.41e-02
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	89	435	3.42e-02
GO:BP	GO:0009185	ribonucleoside diphosphate metabolic process	26	96	3.44e-02
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	181	973	3.47e-02
GO:BP	GO:0097191	extrinsic apoptotic signaling pathway	41	172	3.47e-02
GO:BP	GO:0051258	protein polymerization	51	225	3.48e-02
GO:BP	GO:0009132	nucleoside diphosphate metabolic process	27	101	3.48e-02
GO:BP	GO:0002262	myeloid cell homeostasis	34	136	3.48e-02
GO:BP	GO:0080090	regulation of primary metabolic process	669	4015	3.51e-02
GO:BP	GO:0014910	regulation of smooth muscle cell migration	17	54	3.53e-02
GO:BP	GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	30	116	3.54e-02
GO:BP	GO:0007163	establishment or maintenance of cell polarity	43	183	3.63e-02
GO:BP	GO:0031638	zymogen activation	14	41	3.63e-02
GO:BP	GO:0055085	transmembrane transport	172	921	3.69e-02
GO:BP	GO:0045216	cell-cell junction organization	37	152	3.72e-02
GO:BP	GO:0019915	lipid storage	20	68	3.72e-02
GO:BP	GO:0055002	striated muscle cell development	20	68	3.72e-02
GO:BP	GO:0043436	oxoacid metabolic process	121	621	3.78e-02
GO:BP	GO:0010658	striated muscle cell apoptotic process	13	37	3.81e-02
GO:BP	GO:1903115	regulation of actin filament-based movement	13	37	3.81e-02
GO:BP	GO:0010660	regulation of muscle cell apoptotic process	16	50	3.82e-02
GO:BP	GO:0015918	sterol transport	25	92	3.82e-02
GO:BP	GO:0070373	negative regulation of ERK1 and ERK2 cascade	16	50	3.82e-02
GO:BP	GO:0035914	skeletal muscle cell differentiation	16	50	3.82e-02
GO:BP	GO:1904259	regulation of basement membrane assembly involved in embryonic body morphogenesis	4	5	3.83e-02
GO:BP	GO:1904261	positive regulation of basement membrane assembly involved in embryonic body morphogenesis	4	5	3.83e-02
GO:BP	GO:2001197	basement membrane assembly involved in embryonic body morphogenesis	4	5	3.83e-02
GO:BP	GO:2000669	negative regulation of dendritic cell apoptotic process	4	5	3.83e-02
GO:BP	GO:1904978	regulation of endosome organization	4	5	3.83e-02
GO:BP	GO:0021960	anterior commissure morphogenesis	4	5	3.83e-02
GO:BP	GO:0046898	response to cycloheximide	4	5	3.83e-02
GO:BP	GO:1902267	regulation of polyamine transmembrane transport	4	5	3.83e-02
GO:BP	GO:0097190	apoptotic signaling pathway	94	466	3.85e-02
GO:BP	GO:0006790	sulfur compound metabolic process	52	232	3.88e-02
GO:BP	GO:0010927	cellular component assembly involved in morphogenesis	28	107	3.89e-02
GO:BP	GO:0032232	negative regulation of actin filament bundle assembly	10	25	3.90e-02
GO:BP	GO:1901203	positive regulation of extracellular matrix assembly	7	14	3.90e-02
GO:BP	GO:0060142	regulation of syncytium formation by plasma membrane fusion	7	14	3.90e-02
GO:BP	GO:1904738	vascular associated smooth muscle cell migration	10	25	3.90e-02
GO:BP	GO:0048762	mesenchymal cell differentiation	46	200	3.90e-02
GO:BP	GO:0031325	positive regulation of cellular metabolic process	402	2333	3.95e-02
GO:BP	GO:0072526	pyridine-containing compound catabolic process	22	78	3.96e-02
GO:BP	GO:0009191	ribonucleoside diphosphate catabolic process	22	78	3.96e-02
GO:BP	GO:0055017	cardiac muscle tissue growth	19	64	4.01e-02
GO:BP	GO:1904036	negative regulation of epithelial cell apoptotic process	15	46	4.05e-02
GO:BP	GO:0030182	neuron differentiation	187	1014	4.07e-02
GO:BP	GO:0010657	muscle cell apoptotic process	17	55	4.12e-02
GO:BP	GO:0048598	embryonic morphogenesis	86	422	4.17e-02
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	378	2186	4.24e-02
GO:BP	GO:0030855	epithelial cell differentiation	87	428	4.25e-02
GO:BP	GO:0060538	skeletal muscle organ development	32	128	4.29e-02
GO:BP	GO:0043069	negative regulation of programmed cell death	124	642	4.34e-02
GO:BP	GO:0042326	negative regulation of phosphorylation	53	239	4.36e-02
GO:BP	GO:0022408	negative regulation of cell-cell adhesion	29	113	4.36e-02
GO:BP	GO:1905954	positive regulation of lipid localization	21	74	4.42e-02
GO:BP	GO:0050801	monoatomic ion homeostasis	83	406	4.42e-02
GO:BP	GO:0014854	response to inactivity	6	11	4.46e-02
GO:BP	GO:0014733	regulation of skeletal muscle adaptation	6	11	4.46e-02
GO:BP	GO:1901739	regulation of myoblast fusion	6	11	4.46e-02
GO:BP	GO:0010172	embryonic body morphogenesis	6	11	4.46e-02
GO:BP	GO:0021783	preganglionic parasympathetic fiber development	6	11	4.46e-02
GO:BP	GO:1990874	vascular associated smooth muscle cell proliferation	16	51	4.47e-02
GO:BP	GO:0042058	regulation of epidermal growth factor receptor signaling pathway	16	51	4.47e-02
GO:BP	GO:0030278	regulation of ossification	22	79	4.54e-02
GO:BP	GO:0048666	neuron development	157	838	4.56e-02
GO:BP	GO:0010639	negative regulation of organelle organization	62	289	4.56e-02
GO:BP	GO:1901028	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	8	18	4.61e-02
GO:BP	GO:0055093	response to hyperoxia	8	18	4.61e-02
GO:BP	GO:2000586	regulation of platelet-derived growth factor receptor-beta signaling pathway	5	8	4.66e-02
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	414	2415	4.66e-02
GO:BP	GO:0045861	negative regulation of proteolysis	32	129	4.73e-02
GO:BP	GO:0001933	negative regulation of protein phosphorylation	50	224	4.76e-02
GO:BP	GO:0046434	organophosphate catabolic process	41	176	4.81e-02
GO:BP	GO:0048639	positive regulation of developmental growth	30	119	4.81e-02
GO:BP	GO:0062013	positive regulation of small molecule metabolic process	26	99	4.83e-02
GO:BP	GO:0045766	positive regulation of angiogenesis	29	114	4.83e-02
GO:BP	GO:0003229	ventricular cardiac muscle tissue development	17	56	4.83e-02
GO:BP	GO:0002067	glandular epithelial cell differentiation	15	47	4.83e-02
GO:BP	GO:0097006	regulation of plasma lipoprotein particle levels	15	47	4.83e-02
GO:BP	GO:1903317	regulation of protein maturation	15	47	4.83e-02
GO:BP	GO:0001938	positive regulation of endothelial cell proliferation	20	70	4.84e-02
GO:BP	GO:0043085	positive regulation of catalytic activity	107	546	4.91e-02
GO:BP	GO:0001945	lymph vessel development	9	22	4.91e-02
GO:BP	GO:1900027	regulation of ruffle assembly	9	22	4.91e-02
GO:BP	GO:1903779	regulation of cardiac conduction	9	22	4.91e-02
GO:BP	GO:0030279	negative regulation of ossification	9	22	4.91e-02
GO:BP	GO:0033688	regulation of osteoblast proliferation	9	22	4.91e-02
GO:BP	GO:0051497	negative regulation of stress fiber assembly	9	22	4.91e-02
GO:BP	GO:0051495	positive regulation of cytoskeleton organization	35	145	4.92e-02
GO:BP	GO:0032373	positive regulation of sterol transport	11	30	4.94e-02
GO:BP	GO:0032376	positive regulation of cholesterol transport	11	30	4.94e-02
GO:BP	GO:0043087	regulation of GTPase activity	39	166	4.96e-02
GO:BP	GO:1904035	regulation of epithelial cell apoptotic process	21	75	4.96e-02
GO:BP	GO:0090288	negative regulation of cellular response to growth factor stimulus	21	75	4.96e-02

LRnomtable_20k_enh %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in LR enhancer neargenes_20k") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in LR enhancer neargenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:04261	Adrenergic signaling in cardiomyocytes	43	124	2.31e-05
KEGG	KEGG:05414	Dilated cardiomyopathy	32	82	2.50e-05
KEGG	KEGG:05410	Hypertrophic cardiomyopathy	30	77	4.24e-05
KEGG	KEGG:03320	PPAR signaling pathway	21	47	1.29e-04
KEGG	KEGG:04510	Focal adhesion	48	169	4.37e-04
KEGG	KEGG:05412	Arrhythmogenic right ventricular cardiomyopathy	25	67	4.37e-04
KEGG	KEGG:04925	Aldosterone synthesis and secretion	27	75	4.37e-04
KEGG	KEGG:04971	Gastric acid secretion	20	51	1.23e-03
KEGG	KEGG:05165	Human papillomavirus infection	63	252	1.35e-03
KEGG	KEGG:04928	Parathyroid hormone synthesis, secretion and action	26	78	1.74e-03
KEGG	KEGG:04151	PI3K-Akt signaling pathway	62	250	1.74e-03
KEGG	KEGG:05200	Pathways in cancer	88	391	2.40e-03
KEGG	KEGG:04260	Cardiac muscle contraction	22	63	2.47e-03
KEGG	KEGG:04371	Apelin signaling pathway	31	104	3.08e-03
KEGG	KEGG:04919	Thyroid hormone signaling pathway	31	105	3.49e-03
KEGG	KEGG:04512	ECM-receptor interaction	22	66	4.36e-03
KEGG	KEGG:04927	Cortisol synthesis and secretion	17	46	5.32e-03
KEGG	KEGG:04974	Protein digestion and absorption	19	56	8.00e-03
KEGG	KEGG:04973	Carbohydrate digestion and absorption	12	29	1.11e-02
KEGG	KEGG:04911	Insulin secretion	20	62	1.11e-02
KEGG	KEGG:04022	cGMP-PKG signaling pathway	34	129	1.28e-02
KEGG	KEGG:04148	Efferocytosis	32	120	1.28e-02
KEGG	KEGG:04931	Insulin resistance	26	91	1.28e-02
KEGG	KEGG:04360	Axon guidance	39	155	1.28e-02
KEGG	KEGG:05215	Prostate cancer	24	82	1.28e-02
KEGG	KEGG:04020	Calcium signaling pathway	40	161	1.33e-02
KEGG	KEGG:05205	Proteoglycans in cancer	40	162	1.41e-02
KEGG	KEGG:04015	Rap1 signaling pathway	40	162	1.41e-02
KEGG	KEGG:05203	Viral carcinogenesis	36	142	1.42e-02
KEGG	KEGG:04972	Pancreatic secretion	18	57	1.74e-02
KEGG	KEGG:05146	Amoebiasis	19	62	1.82e-02
KEGG	KEGG:05163	Human cytomegalovirus infection	39	160	1.82e-02
KEGG	KEGG:00000	KEGG root term	893	5451	1.83e-02
KEGG	KEGG:04750	Inflammatory mediator regulation of TRP channels	21	72	2.00e-02
KEGG	KEGG:05222	Small cell lung cancer	23	82	2.15e-02
KEGG	KEGG:04713	Circadian entrainment	20	68	2.15e-02
KEGG	KEGG:00330	Arginine and proline metabolism	12	33	2.22e-02
KEGG	KEGG:04740	Olfactory transduction	10	25	2.22e-02
KEGG	KEGG:04520	Adherens junction	23	83	2.29e-02
KEGG	KEGG:04611	Platelet activation	24	88	2.30e-02
KEGG	KEGG:05131	Shigellosis	46	204	3.02e-02
KEGG	KEGG:04330	Notch signaling pathway	16	52	3.02e-02
KEGG	KEGG:04930	Type II diabetes mellitus	12	35	3.33e-02
KEGG	KEGG:04024	cAMP signaling pathway	35	147	3.33e-02
KEGG	KEGG:04933	AGE-RAGE signaling pathway in diabetic complications	23	87	3.76e-02
KEGG	KEGG:04961	Endocrine and other factor-regulated calcium reabsorption	13	40	3.76e-02
KEGG	KEGG:05418	Fluid shear stress and atherosclerosis	27	109	4.52e-02
KEGG	KEGG:04976	Bile secretion	13	41	4.52e-02
KEGG	KEGG:04934	Cushing syndrome	29	119	4.52e-02
KEGG	KEGG:00532	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate	8	20	4.54e-02

NR 20,000 bp NG

# NR_resgenes_20k <- gost(query = NR_peak_list_20k$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(NR_resgenes_20k,"data/GO_KEGG_analysis/NR_resgenes_20k.RDS")


# NRnom <- gostplot(NR_resgenes_20k, capped = FALSE, interactive = TRUE)
# NRnom

NRnomtable_20k <- NR_resgenes_20k$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

NRnomtable_20k %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in NR nESRgenes_20k" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in NR nESRgenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0032501	multicellular organismal process	4317	4504	9.74e-06
GO:BP	GO:0007275	multicellular organism development	3050	3170	1.83e-05
GO:BP	GO:0048856	anatomical structure development	3708	3867	6.42e-05
GO:BP	GO:0048731	system development	2618	2719	7.09e-05
GO:BP	GO:0008150	biological_process	10636	11244	8.31e-05
GO:BP	GO:0032502	developmental process	4001	4179	8.31e-05
GO:BP	GO:0048523	negative regulation of cellular process	3406	3550	8.31e-05
GO:BP	GO:0051716	cellular response to stimulus	4437	4640	8.31e-05
GO:BP	GO:0050794	regulation of cellular process	6806	7153	1.22e-04
GO:BP	GO:0050896	response to stimulus	5133	5379	1.72e-04
GO:BP	GO:0065007	biological regulation	7350	7734	2.63e-04
GO:BP	GO:0050789	regulation of biological process	7144	7516	3.70e-04
GO:BP	GO:0007154	cell communication	3811	3983	3.83e-04
GO:BP	GO:0023052	signaling	3749	3918	4.40e-04
GO:BP	GO:0007010	cytoskeleton organization	1113	1146	8.70e-04
GO:BP	GO:0007399	nervous system development	1713	1775	9.59e-04
GO:BP	GO:0009987	cellular process	10111	10686	9.59e-04
GO:BP	GO:0007165	signal transduction	3456	3611	9.61e-04
GO:BP	GO:0009653	anatomical structure morphogenesis	1778	1844	1.25e-03
GO:BP	GO:0071495	cellular response to endogenous stimulus	1006	1035	1.25e-03
GO:BP	GO:0022008	neurogenesis	1212	1251	1.74e-03
GO:BP	GO:0048519	negative regulation of biological process	3599	3764	1.74e-03
GO:BP	GO:0048869	cellular developmental process	2688	2804	2.76e-03
GO:BP	GO:0007015	actin filament organization	353	357	2.76e-03
GO:BP	GO:0016043	cellular component organization	4579	4802	2.76e-03
GO:BP	GO:0030154	cell differentiation	2687	2803	2.76e-03
GO:BP	GO:0030029	actin filament-based process	626	640	2.76e-03
GO:BP	GO:0048518	positive regulation of biological process	4105	4301	2.96e-03
GO:BP	GO:0023051	regulation of signaling	2340	2438	3.51e-03
GO:BP	GO:0048522	positive regulation of cellular process	3776	3954	3.89e-03
GO:BP	GO:0048699	generation of neurons	1043	1076	4.39e-03
GO:BP	GO:0050793	regulation of developmental process	1635	1697	4.59e-03
GO:BP	GO:0035556	intracellular signal transduction	1876	1951	5.84e-03
GO:BP	GO:0009888	tissue development	1302	1348	5.84e-03
GO:BP	GO:0009719	response to endogenous stimulus	1158	1197	5.84e-03
GO:BP	GO:0032970	regulation of actin filament-based process	297	300	6.20e-03
GO:BP	GO:0010646	regulation of cell communication	2344	2444	6.20e-03
GO:BP	GO:0030182	neuron differentiation	983	1014	6.20e-03
GO:BP	GO:0097435	supramolecular fiber organization	618	633	6.72e-03
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	259	261	7.37e-03
GO:BP	GO:0006996	organelle organization	2695	2815	8.01e-03
GO:BP	GO:0009966	regulation of signal transduction	2079	2166	8.77e-03
GO:BP	GO:0048468	cell development	1813	1886	8.77e-03
GO:BP	GO:0048513	animal organ development	1925	2004	9.14e-03
GO:BP	GO:0051128	regulation of cellular component organization	1790	1862	9.19e-03
GO:BP	GO:0007267	cell-cell signaling	1047	1082	9.96e-03
GO:BP	GO:0030036	actin cytoskeleton organization	553	566	1.03e-02
GO:BP	GO:0032870	cellular response to hormone stimulus	425	433	1.03e-02
GO:BP	GO:0000902	cell morphogenesis	694	713	1.03e-02
GO:BP	GO:0048583	regulation of response to stimulus	2601	2717	1.03e-02
GO:BP	GO:0071840	cellular component organization or biogenesis	4749	4988	1.03e-02
GO:BP	GO:0043087	regulation of GTPase activity	166	166	1.22e-02
GO:BP	GO:0016477	cell migration	978	1011	1.97e-02
GO:BP	GO:0198738	cell-cell signaling by wnt	353	359	2.16e-02
GO:BP	GO:0016055	Wnt signaling pathway	352	358	2.22e-02
GO:BP	GO:0051493	regulation of cytoskeleton organization	404	412	2.31e-02
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	1110	1150	2.63e-02
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	2312	2415	2.73e-02
GO:BP	GO:0030030	cell projection organization	1140	1182	3.40e-02
GO:BP	GO:0051239	regulation of multicellular organismal process	1845	1924	4.34e-02

NRnomtable_20k %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in NR nESRgenes_20k") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in NR nESRgenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
NA	NA	NA	NA	NA	NA
:——	:——-	:———	—————–:	———:	:——-

NR peaks overlapping enhancers

# NR_resgenes_20k_enh <- gost(query = unique(NR_enh_peaks_20k$NCBI_gene),
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = FALSE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = background_df$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(NR_resgenes_20k_enh,"data/GO_KEGG_analysis/NR_resgenes_20k_enh.RDS")


# NRnom <- gostplot(NR_resgenes_20k_enh, capped = FALSE, interactive = TRUE)
# NRnom

NRnomtable_20k_enh <- NR_resgenes_20k_enh$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

NRnomtable_20k_enh %>%
   filter(source=="GO:BP", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(.,caption = "GO:BP terms found in NR neargenes_20k" ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

GO:BP terms found in NR neargenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0065007	biological regulation	4230	7734	9.66e-28
GO:BP	GO:0050789	regulation of biological process	4120	7516	1.29e-27
GO:BP	GO:0050794	regulation of cellular process	3931	7153	3.23e-26
GO:BP	GO:0048523	negative regulation of cellular process	2068	3550	5.64e-24
GO:BP	GO:0007165	signal transduction	2097	3611	1.83e-23
GO:BP	GO:0048519	negative regulation of biological process	2176	3764	3.12e-23
GO:BP	GO:0051716	cellular response to stimulus	2632	4640	5.29e-23
GO:BP	GO:0050896	response to stimulus	3012	5379	6.75e-23
GO:BP	GO:0008150	biological_process	5864	11244	8.77e-23
GO:BP	GO:0023052	signaling	2243	3918	5.28e-21
GO:BP	GO:0048518	positive regulation of biological process	2442	4301	7.27e-21
GO:BP	GO:0007154	cell communication	2275	3983	9.78e-21
GO:BP	GO:0019222	regulation of metabolic process	2585	4603	9.97e-19
GO:BP	GO:0009893	positive regulation of metabolic process	1539	2622	4.31e-18
GO:BP	GO:0048522	positive regulation of cellular process	2243	3954	4.41e-18
GO:BP	GO:0048583	regulation of response to stimulus	1588	2717	8.05e-18
GO:BP	GO:0071310	cellular response to organic substance	813	1297	1.07e-17
GO:BP	GO:0009987	cellular process	5587	10686	1.45e-17
GO:BP	GO:0070887	cellular response to chemical stimulus	1063	1751	2.03e-17
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	997	1633	3.36e-17
GO:BP	GO:0010033	response to organic substance	1053	1736	4.29e-17
GO:BP	GO:0060255	regulation of macromolecule metabolic process	2378	4231	8.17e-17
GO:BP	GO:0051254	positive regulation of RNA metabolic process	840	1354	1.08e-16
GO:BP	GO:0009719	response to endogenous stimulus	752	1197	1.19e-16
GO:BP	GO:0009966	regulation of signal transduction	1284	2166	1.42e-16
GO:BP	GO:0080090	regulation of primary metabolic process	2263	4015	1.63e-16
GO:BP	GO:0042221	response to chemical	1358	2304	1.63e-16
GO:BP	GO:0009892	negative regulation of metabolic process	1247	2100	2.22e-16
GO:BP	GO:0051252	regulation of RNA metabolic process	1549	2663	2.59e-16
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	1416	2415	2.82e-16
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	1165	1951	3.39e-16
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	1292	2186	3.63e-16
GO:BP	GO:0030029	actin filament-based process	431	640	3.91e-16
GO:BP	GO:0071495	cellular response to endogenous stimulus	658	1035	4.03e-16
GO:BP	GO:0031324	negative regulation of cellular metabolic process	1155	1934	4.21e-16
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	2208	3918	5.56e-16
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	617	965	8.15e-16
GO:BP	GO:0031323	regulation of cellular metabolic process	2370	4233	1.00e-15
GO:BP	GO:0035556	intracellular signal transduction	1162	1951	1.00e-15
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	621	973	1.04e-15
GO:BP	GO:0032502	developmental process	2340	4179	1.77e-15
GO:BP	GO:0051253	negative regulation of RNA metabolic process	673	1067	1.89e-15
GO:BP	GO:0010468	regulation of gene expression	1921	3379	2.41e-15
GO:BP	GO:2001141	regulation of RNA biosynthetic process	1412	2422	4.20e-15
GO:BP	GO:0006355	regulation of DNA-templated transcription	1405	2410	5.14e-15
GO:BP	GO:0031325	positive regulation of cellular metabolic process	1362	2333	9.91e-15
GO:BP	GO:0048856	anatomical structure development	2172	3867	9.91e-15
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	917	1514	1.50e-14
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	957	1588	1.92e-14
GO:BP	GO:0010646	regulation of cell communication	1419	2444	2.31e-14
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	761	1234	2.75e-14
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	1969	3486	3.09e-14
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	759	1231	3.09e-14
GO:BP	GO:0030036	actin cytoskeleton organization	381	566	3.09e-14
GO:BP	GO:0006351	DNA-templated transcription	1452	2510	4.74e-14
GO:BP	GO:1901698	response to nitrogen compound	479	736	4.74e-14
GO:BP	GO:0032774	RNA biosynthetic process	1464	2533	5.13e-14
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	974	1624	5.40e-14
GO:BP	GO:0023051	regulation of signaling	1413	2438	5.59e-14
GO:BP	GO:0007166	cell surface receptor signaling pathway	1070	1801	6.07e-14
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	716	1157	6.93e-14
GO:BP	GO:0009890	negative regulation of biosynthetic process	979	1635	7.85e-14
GO:BP	GO:0009653	anatomical structure morphogenesis	1092	1844	1.00e-13
GO:BP	GO:0009889	regulation of biosynthetic process	2021	3595	1.35e-13
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	1653	2895	1.37e-13
GO:BP	GO:0031326	regulation of cellular biosynthetic process	2007	3569	1.50e-13
GO:BP	GO:0010243	response to organonitrogen compound	447	685	2.19e-13
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	1059	1791	5.37e-13
GO:BP	GO:0050793	regulation of developmental process	1008	1697	5.37e-13
GO:BP	GO:0048869	cellular developmental process	1600	2804	6.75e-13
GO:BP	GO:0030154	cell differentiation	1599	2803	7.81e-13
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	1055	1787	1.08e-12
GO:BP	GO:0009891	positive regulation of biosynthetic process	1091	1856	1.78e-12
GO:BP	GO:0045595	regulation of cell differentiation	662	1073	2.23e-12
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	1082	1841	2.47e-12
GO:BP	GO:1901699	cellular response to nitrogen compound	323	479	3.53e-12
GO:BP	GO:0036211	protein modification process	1322	2291	4.14e-12
GO:BP	GO:1901701	cellular response to oxygen-containing compound	505	796	4.89e-12
GO:BP	GO:0141124	intracellular signaling cassette	793	1314	5.91e-12
GO:BP	GO:0071417	cellular response to organonitrogen compound	300	442	8.21e-12
GO:BP	GO:1901700	response to oxygen-containing compound	670	1093	9.42e-12
GO:BP	GO:1902531	regulation of intracellular signal transduction	777	1289	1.57e-11
GO:BP	GO:0006366	transcription by RNA polymerase II	1097	1879	1.83e-11
GO:BP	GO:0018130	heterocycle biosynthetic process	1654	2927	2.01e-11
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	1705	3026	2.77e-11
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	1621	2867	3.05e-11
GO:BP	GO:0019438	aromatic compound biosynthetic process	1652	2928	4.27e-11
GO:BP	GO:0045596	negative regulation of cell differentiation	303	452	6.27e-11
GO:BP	GO:0009725	response to hormone	394	610	8.60e-11
GO:BP	GO:0097435	supramolecular fiber organization	407	633	9.37e-11
GO:BP	GO:0048585	negative regulation of response to stimulus	720	1193	9.39e-11
GO:BP	GO:0032870	cellular response to hormone stimulus	291	433	1.11e-10
GO:BP	GO:0009968	negative regulation of signal transduction	597	972	1.38e-10
GO:BP	GO:0051093	negative regulation of developmental process	400	622	1.38e-10
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	542	874	1.63e-10
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	446	704	1.96e-10
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	453	717	2.37e-10
GO:BP	GO:0051239	regulation of multicellular organismal process	1113	1924	3.01e-10
GO:BP	GO:0007275	multicellular organism development	1772	3170	3.07e-10
GO:BP	GO:0032501	multicellular organismal process	2464	4504	3.29e-10
GO:BP	GO:0007015	actin filament organization	244	357	5.05e-10
GO:BP	GO:0023057	negative regulation of signaling	629	1036	6.35e-10
GO:BP	GO:0043434	response to peptide hormone	218	314	6.60e-10
GO:BP	GO:0048584	positive regulation of response to stimulus	884	1504	8.18e-10
GO:BP	GO:0010648	negative regulation of cell communication	627	1034	9.27e-10
GO:BP	GO:1901652	response to peptide	249	368	1.52e-09
GO:BP	GO:0016477	cell migration	612	1011	2.57e-09
GO:BP	GO:0072359	circulatory system development	529	864	5.47e-09
GO:BP	GO:0007010	cytoskeleton organization	684	1146	6.28e-09
GO:BP	GO:0001944	vasculature development	353	552	7.66e-09
GO:BP	GO:0008152	metabolic process	4177	7921	1.78e-08
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	1926	3495	1.88e-08
GO:BP	GO:0009605	response to external stimulus	903	1559	3.62e-08
GO:BP	GO:0032868	response to insulin	146	203	3.94e-08
GO:BP	GO:0030155	regulation of cell adhesion	325	508	4.00e-08
GO:BP	GO:0071375	cellular response to peptide hormone stimulus	163	231	4.09e-08
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	295	456	4.54e-08
GO:BP	GO:0006793	phosphorus metabolic process	1086	1904	5.64e-08
GO:BP	GO:0001568	blood vessel development	334	525	5.72e-08
GO:BP	GO:0045597	positive regulation of cell differentiation	371	591	6.96e-08
GO:BP	GO:0009888	tissue development	787	1348	7.67e-08
GO:BP	GO:0198738	cell-cell signaling by wnt	238	359	7.75e-08
GO:BP	GO:0048513	animal organ development	1138	2004	7.75e-08
GO:BP	GO:0048731	system development	1515	2719	8.04e-08
GO:BP	GO:0002376	immune system process	820	1410	8.73e-08
GO:BP	GO:0006796	phosphate-containing compound metabolic process	1073	1883	9.32e-08
GO:BP	GO:0016055	Wnt signaling pathway	237	358	9.96e-08
GO:BP	GO:1901653	cellular response to peptide	187	273	9.97e-08
GO:BP	GO:0044238	primary metabolic process	3816	7216	1.09e-07
GO:BP	GO:0071407	cellular response to organic cyclic compound	249	379	1.11e-07
GO:BP	GO:0030334	regulation of cell migration	413	668	1.20e-07
GO:BP	GO:0065009	regulation of molecular function	759	1299	1.22e-07
GO:BP	GO:0019538	protein metabolic process	1982	3619	1.27e-07
GO:BP	GO:0065008	regulation of biological quality	1077	1893	1.32e-07
GO:BP	GO:0016310	phosphorylation	675	1145	1.45e-07
GO:BP	GO:0032970	regulation of actin filament-based process	202	300	1.95e-07
GO:BP	GO:0043412	macromolecule modification	1390	2489	2.29e-07
GO:BP	GO:0051246	regulation of protein metabolic process	916	1595	2.43e-07
GO:BP	GO:0051179	localization	2037	3731	2.47e-07
GO:BP	GO:0061061	muscle structure development	337	536	2.89e-07
GO:BP	GO:0071704	organic substance metabolic process	3992	7578	3.25e-07
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	277	431	3.43e-07
GO:BP	GO:0006810	transport	1647	2984	3.85e-07
GO:BP	GO:0007155	cell adhesion	561	941	3.97e-07
GO:BP	GO:0008283	cell population proliferation	759	1306	4.22e-07
GO:BP	GO:0043170	macromolecule metabolic process	3474	6550	4.26e-07
GO:BP	GO:0030097	hemopoiesis	385	624	5.69e-07
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	503	837	5.69e-07
GO:BP	GO:0051336	regulation of hydrolase activity	276	431	5.89e-07
GO:BP	GO:0035295	tube development	475	787	6.84e-07
GO:BP	GO:0040011	locomotion	484	805	1.01e-06
GO:BP	GO:2000145	regulation of cell motility	426	700	1.01e-06
GO:BP	GO:0051094	positive regulation of developmental process	543	913	1.10e-06
GO:BP	GO:0046907	intracellular transport	677	1160	1.21e-06
GO:BP	GO:0042127	regulation of cell population proliferation	632	1077	1.22e-06
GO:BP	GO:0060070	canonical Wnt signaling pathway	165	242	1.31e-06
GO:BP	GO:0006468	protein phosphorylation	567	958	1.34e-06
GO:BP	GO:0014070	response to organic cyclic compound	373	606	1.36e-06
GO:BP	GO:0040012	regulation of locomotion	436	720	1.55e-06
GO:BP	GO:0009967	positive regulation of signal transduction	639	1093	2.16e-06
GO:BP	GO:0048468	cell development	1063	1886	2.24e-06
GO:BP	GO:0048870	cell motility	653	1120	2.65e-06
GO:BP	GO:0042592	homeostatic process	662	1137	2.81e-06
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	373	609	2.89e-06
GO:BP	GO:0016070	RNA metabolic process	1829	3352	3.05e-06
GO:BP	GO:0006807	nitrogen compound metabolic process	3646	6912	3.19e-06
GO:BP	GO:0051240	positive regulation of multicellular organismal process	609	1040	3.29e-06
GO:BP	GO:0016567	protein ubiquitination	377	617	3.47e-06
GO:BP	GO:0032869	cellular response to insulin stimulus	115	161	3.66e-06
GO:BP	GO:0006915	apoptotic process	790	1377	3.84e-06
GO:BP	GO:0070647	protein modification by small protein conjugation or removal	459	766	3.92e-06
GO:BP	GO:0048514	blood vessel morphogenesis	283	450	4.25e-06
GO:BP	GO:0006950	response to stress	1404	2540	4.76e-06
GO:BP	GO:0043687	post-translational protein modification	483	811	5.09e-06
GO:BP	GO:0044092	negative regulation of molecular function	313	504	5.16e-06
GO:BP	GO:0012501	programmed cell death	811	1419	5.87e-06
GO:BP	GO:0044237	cellular metabolic process	3716	7058	5.91e-06
GO:BP	GO:0030099	myeloid cell differentiation	192	292	5.94e-06
GO:BP	GO:0051248	negative regulation of protein metabolic process	369	605	6.01e-06
GO:BP	GO:0031399	regulation of protein modification process	536	911	8.98e-06
GO:BP	GO:0002684	positive regulation of immune system process	354	580	9.88e-06
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	139	203	1.01e-05
GO:BP	GO:0016043	cellular component organization	2569	4802	1.02e-05
GO:BP	GO:0033993	response to lipid	350	573	1.02e-05
GO:BP	GO:0035239	tube morphogenesis	386	638	1.03e-05
GO:BP	GO:0008219	cell death	811	1423	1.06e-05
GO:BP	GO:0032956	regulation of actin cytoskeleton organization	173	261	1.07e-05
GO:BP	GO:0030111	regulation of Wnt signaling pathway	173	261	1.07e-05
GO:BP	GO:1901564	organonitrogen compound metabolic process	2339	4354	1.09e-05
GO:BP	GO:0009894	regulation of catabolic process	490	830	1.73e-05
GO:BP	GO:0060284	regulation of cell development	347	570	1.78e-05
GO:BP	GO:0032446	protein modification by small protein conjugation	416	695	1.78e-05
GO:BP	GO:0042692	muscle cell differentiation	208	323	1.78e-05
GO:BP	GO:0030335	positive regulation of cell migration	249	395	1.78e-05
GO:BP	GO:0051234	establishment of localization	1762	3240	1.81e-05
GO:BP	GO:0051174	regulation of phosphorus metabolic process	476	805	1.92e-05
GO:BP	GO:0070848	response to growth factor	334	547	1.94e-05
GO:BP	GO:0044249	cellular biosynthetic process	2897	5453	2.03e-05
GO:BP	GO:0007507	heart development	307	499	2.17e-05
GO:BP	GO:1901576	organic substance biosynthetic process	2925	5509	2.20e-05
GO:BP	GO:0019220	regulation of phosphate metabolic process	475	804	2.23e-05
GO:BP	GO:0051493	regulation of cytoskeleton organization	258	412	2.35e-05
GO:BP	GO:0023056	positive regulation of signaling	700	1221	2.41e-05
GO:BP	GO:0030522	intracellular receptor signaling pathway	167	253	2.44e-05
GO:BP	GO:0010629	negative regulation of gene expression	467	790	2.51e-05
GO:BP	GO:0044419	biological process involved in interspecies interaction between organisms	544	932	2.66e-05
GO:BP	GO:0051128	regulation of cellular component organization	1040	1862	2.78e-05
GO:BP	GO:2000026	regulation of multicellular organismal development	554	951	2.91e-05
GO:BP	GO:1902903	regulation of supramolecular fiber organization	196	304	3.18e-05
GO:BP	GO:0031400	negative regulation of protein modification process	208	325	3.21e-05
GO:BP	GO:0043254	regulation of protein-containing complex assembly	209	327	3.46e-05
GO:BP	GO:0010647	positive regulation of cell communication	697	1218	3.54e-05
GO:BP	GO:0009058	biosynthetic process	2941	5547	3.81e-05
GO:BP	GO:0009059	macromolecule biosynthetic process	2574	4827	3.83e-05
GO:BP	GO:0042981	regulation of apoptotic process	596	1031	4.20e-05
GO:BP	GO:0050790	regulation of catalytic activity	521	893	4.89e-05
GO:BP	GO:0043067	regulation of programmed cell death	611	1060	5.07e-05
GO:BP	GO:0071363	cellular response to growth factor stimulus	321	528	5.32e-05
GO:BP	GO:0002682	regulation of immune system process	507	868	5.65e-05
GO:BP	GO:0016192	vesicle-mediated transport	660	1152	5.65e-05
GO:BP	GO:0034097	response to cytokine	354	588	5.67e-05
GO:BP	GO:0080134	regulation of response to stress	539	928	6.55e-05
GO:BP	GO:0009991	response to extracellular stimulus	236	377	6.93e-05
GO:BP	GO:0050776	regulation of immune response	292	477	6.98e-05
GO:BP	GO:0001525	angiogenesis	238	381	7.84e-05
GO:BP	GO:0051146	striated muscle cell differentiation	154	234	8.08e-05
GO:BP	GO:2000147	positive regulation of cell motility	253	408	8.51e-05
GO:BP	GO:0048762	mesenchymal cell differentiation	134	200	8.90e-05
GO:BP	GO:0071345	cellular response to cytokine stimulus	318	525	9.14e-05
GO:BP	GO:0000902	cell morphogenesis	421	713	1.01e-04
GO:BP	GO:0050778	positive regulation of immune response	235	377	1.12e-04
GO:BP	GO:0071396	cellular response to lipid	241	388	1.22e-04
GO:BP	GO:0007264	small GTPase-mediated signal transduction	242	390	1.30e-04
GO:BP	GO:0001667	ameboidal-type cell migration	216	344	1.36e-04
GO:BP	GO:0070936	protein K48-linked ubiquitination	57	74	1.36e-04
GO:BP	GO:0045936	negative regulation of phosphate metabolic process	184	288	1.50e-04
GO:BP	GO:0051247	positive regulation of protein metabolic process	527	911	1.57e-04
GO:BP	GO:0061448	connective tissue development	136	205	1.63e-04
GO:BP	GO:0010467	gene expression	2372	4449	1.64e-04
GO:BP	GO:0040017	positive regulation of locomotion	256	416	1.65e-04
GO:BP	GO:0006897	endocytosis	298	492	1.85e-04
GO:BP	GO:0051345	positive regulation of hydrolase activity	171	266	1.87e-04
GO:BP	GO:0044087	regulation of cellular component biogenesis	443	757	1.94e-04
GO:BP	GO:0033554	cellular response to stress	805	1433	1.96e-04
GO:BP	GO:0044093	positive regulation of molecular function	457	783	1.99e-04
GO:BP	GO:0010563	negative regulation of phosphorus metabolic process	184	289	2.00e-04
GO:BP	GO:0032879	regulation of localization	808	1439	2.03e-04
GO:BP	GO:0006955	immune response	502	867	2.27e-04
GO:BP	GO:0006470	protein dephosphorylation	119	177	2.36e-04
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	419	714	2.36e-04
GO:BP	GO:0016311	dephosphorylation	151	232	2.38e-04
GO:BP	GO:0048872	homeostasis of number of cells	145	222	2.74e-04
GO:BP	GO:0001837	epithelial to mesenchymal transition	95	137	2.87e-04
GO:BP	GO:0032922	circadian regulation of gene expression	46	58	2.88e-04
GO:BP	GO:0031667	response to nutrient levels	220	354	2.89e-04
GO:BP	GO:0051241	negative regulation of multicellular organismal process	414	706	2.91e-04
GO:BP	GO:0008285	negative regulation of cell population proliferation	284	469	3.01e-04
GO:BP	GO:0060485	mesenchyme development	158	245	3.12e-04
GO:BP	GO:0098657	import into cell	368	622	3.13e-04
GO:BP	GO:0071496	cellular response to external stimulus	171	268	3.40e-04
GO:BP	GO:0051641	cellular localization	1426	2623	3.50e-04
GO:BP	GO:0010717	regulation of epithelial to mesenchymal transition	63	85	3.55e-04
GO:BP	GO:0014902	myotube differentiation	63	85	3.55e-04
GO:BP	GO:0034101	erythrocyte homeostasis	79	111	3.58e-04
GO:BP	GO:0007162	negative regulation of cell adhesion	123	185	3.63e-04
GO:BP	GO:0043065	positive regulation of apoptotic process	234	380	3.66e-04
GO:BP	GO:0003012	muscle system process	203	325	3.91e-04
GO:BP	GO:0009896	positive regulation of catabolic process	265	436	3.95e-04
GO:BP	GO:0048871	multicellular organismal-level homeostasis	320	536	4.27e-04
GO:BP	GO:0007520	myoblast fusion	26	29	4.50e-04
GO:BP	GO:0032271	regulation of protein polymerization	108	160	4.50e-04
GO:BP	GO:0031032	actomyosin structure organization	122	184	4.70e-04
GO:BP	GO:0010631	epithelial cell migration	156	243	4.88e-04
GO:BP	GO:0090132	epithelium migration	156	243	4.88e-04
GO:BP	GO:0045444	fat cell differentiation	119	179	4.92e-04
GO:BP	GO:0003170	heart valve development	50	65	5.13e-04
GO:BP	GO:0002253	activation of immune response	182	289	5.35e-04
GO:BP	GO:0022604	regulation of cell morphogenesis	127	193	5.37e-04
GO:BP	GO:0110053	regulation of actin filament organization	138	212	5.37e-04
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	150	233	5.61e-04
GO:BP	GO:0030218	erythrocyte differentiation	74	104	6.58e-04
GO:BP	GO:0071840	cellular component organization or biogenesis	2638	4988	6.67e-04
GO:BP	GO:0010628	positive regulation of gene expression	433	746	6.67e-04
GO:BP	GO:0010921	regulation of phosphatase activity	36	44	7.55e-04
GO:BP	GO:0002262	myeloid cell homeostasis	93	136	7.81e-04
GO:BP	GO:0045785	positive regulation of cell adhesion	188	301	7.81e-04
GO:BP	GO:0008360	regulation of cell shape	75	106	7.81e-04
GO:BP	GO:2000628	regulation of miRNA metabolic process	54	72	8.11e-04
GO:BP	GO:0090257	regulation of muscle system process	117	177	8.26e-04
GO:BP	GO:0030323	respiratory tube development	100	148	8.30e-04
GO:BP	GO:0002521	leukocyte differentiation	227	371	8.49e-04
GO:BP	GO:0009607	response to biotic stimulus	472	820	8.65e-04
GO:BP	GO:0008286	insulin receptor signaling pathway	70	98	8.65e-04
GO:BP	GO:0042325	regulation of phosphorylation	398	683	8.70e-04
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	178	284	9.37e-04
GO:BP	GO:0090130	tissue migration	157	247	9.47e-04
GO:BP	GO:0031668	cellular response to extracellular stimulus	141	219	9.47e-04
GO:BP	GO:0010810	regulation of cell-substrate adhesion	108	162	9.48e-04
GO:BP	GO:0003179	heart valve morphogenesis	43	55	9.59e-04
GO:BP	GO:0051129	negative regulation of cellular component organization	328	555	9.74e-04
GO:BP	GO:0046649	lymphocyte activation	267	444	1.00e-03
GO:BP	GO:0043068	positive regulation of programmed cell death	236	388	1.01e-03
GO:BP	GO:0014897	striated muscle hypertrophy	55	74	1.01e-03
GO:BP	GO:0035966	response to topologically incorrect protein	89	130	1.03e-03
GO:BP	GO:0045646	regulation of erythrocyte differentiation	29	34	1.03e-03
GO:BP	GO:0031589	cell-substrate adhesion	163	258	1.05e-03
GO:BP	GO:0010586	miRNA metabolic process	63	87	1.06e-03
GO:BP	GO:0051707	response to other organism	457	794	1.13e-03
GO:BP	GO:0043207	response to external biotic stimulus	457	794	1.13e-03
GO:BP	GO:0048878	chemical homeostasis	390	670	1.14e-03
GO:BP	GO:0043087	regulation of GTPase activity	110	166	1.15e-03
GO:BP	GO:0051494	negative regulation of cytoskeleton organization	87	127	1.18e-03
GO:BP	GO:1902893	regulation of miRNA transcription	46	60	1.18e-03
GO:BP	GO:0008064	regulation of actin polymerization or depolymerization	81	117	1.21e-03
GO:BP	GO:0030324	lung development	97	144	1.23e-03
GO:BP	GO:0006996	organelle organization	1518	2815	1.23e-03
GO:BP	GO:0036293	response to decreased oxygen levels	154	243	1.33e-03
GO:BP	GO:0055001	muscle cell development	108	163	1.33e-03
GO:BP	GO:0001775	cell activation	366	627	1.41e-03
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	76	109	1.41e-03
GO:BP	GO:0003300	cardiac muscle hypertrophy	54	73	1.42e-03
GO:BP	GO:0002764	immune response-regulating signaling pathway	168	268	1.43e-03
GO:BP	GO:0052547	regulation of peptidase activity	113	172	1.53e-03
GO:BP	GO:0008154	actin polymerization or depolymerization	99	148	1.53e-03
GO:BP	GO:0071559	response to transforming growth factor beta	140	219	1.56e-03
GO:BP	GO:0051049	regulation of transport	618	1098	1.65e-03
GO:BP	GO:0002757	immune response-activating signaling pathway	162	258	1.69e-03
GO:BP	GO:0032101	regulation of response to external stimulus	380	654	1.70e-03
GO:BP	GO:1901201	regulation of extracellular matrix assembly	18	19	1.74e-03
GO:BP	GO:0014896	muscle hypertrophy	55	75	1.78e-03
GO:BP	GO:0034109	homotypic cell-cell adhesion	50	67	1.80e-03
GO:BP	GO:0030832	regulation of actin filament length	81	118	1.85e-03
GO:BP	GO:0080135	regulation of cellular response to stress	263	440	1.90e-03
GO:BP	GO:1903131	mononuclear cell differentiation	173	278	1.91e-03
GO:BP	GO:0140747	regulation of ncRNA transcription	58	80	1.91e-03
GO:BP	GO:0001932	regulation of protein phosphorylation	373	642	1.96e-03
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	156	248	1.97e-03
GO:BP	GO:0071383	cellular response to steroid hormone stimulus	105	159	1.97e-03
GO:BP	GO:0048384	retinoic acid receptor signaling pathway	23	26	2.02e-03
GO:BP	GO:1903706	regulation of hemopoiesis	161	257	2.04e-03
GO:BP	GO:0033036	macromolecule localization	1252	2309	2.17e-03
GO:BP	GO:0141091	transforming growth factor beta receptor superfamily signaling pathway	162	259	2.17e-03
GO:BP	GO:0006325	chromatin organization	352	604	2.21e-03
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	137	215	2.23e-03
GO:BP	GO:0061614	miRNA transcription	46	61	2.23e-03
GO:BP	GO:0031669	cellular response to nutrient levels	126	196	2.40e-03
GO:BP	GO:0035967	cellular response to topologically incorrect protein	62	87	2.40e-03
GO:BP	GO:0009887	animal organ morphogenesis	389	673	2.43e-03
GO:BP	GO:0030048	actin filament-based movement	74	107	2.51e-03
GO:BP	GO:0001570	vasculogenesis	49	66	2.54e-03
GO:BP	GO:0030098	lymphocyte differentiation	156	249	2.55e-03
GO:BP	GO:0035303	regulation of dephosphorylation	57	79	2.63e-03
GO:BP	GO:0000165	MAPK cascade	297	504	2.68e-03
GO:BP	GO:0051235	maintenance of location	157	251	2.70e-03
GO:BP	GO:0009611	response to wounding	230	382	2.74e-03
GO:BP	GO:0006338	chromatin remodeling	287	486	2.84e-03
GO:BP	GO:0043433	negative regulation of DNA-binding transcription factor activity	72	104	2.90e-03
GO:BP	GO:0032535	regulation of cellular component size	177	287	2.99e-03
GO:BP	GO:1903902	positive regulation of viral life cycle	17	18	3.00e-03
GO:BP	GO:0042326	negative regulation of phosphorylation	150	239	3.00e-03
GO:BP	GO:0001666	response to hypoxia	146	232	3.05e-03
GO:BP	GO:0051649	establishment of localization in cell	862	1566	3.07e-03
GO:BP	GO:1990845	adaptive thermogenesis	82	121	3.07e-03
GO:BP	GO:0090066	regulation of anatomical structure size	228	379	3.07e-03
GO:BP	GO:1902905	positive regulation of supramolecular fiber organization	92	138	3.07e-03
GO:BP	GO:0009952	anterior/posterior pattern specification	82	121	3.07e-03
GO:BP	GO:0003007	heart morphogenesis	138	218	3.10e-03
GO:BP	GO:0098609	cell-cell adhesion	329	564	3.23e-03
GO:BP	GO:0120161	regulation of cold-induced thermogenesis	76	111	3.23e-03
GO:BP	GO:0032989	cellular anatomical entity morphogenesis	342	588	3.23e-03
GO:BP	GO:0010720	positive regulation of cell development	189	309	3.30e-03
GO:BP	GO:0031329	regulation of cellular catabolic process	324	555	3.33e-03
GO:BP	GO:0097581	lamellipodium organization	53	73	3.37e-03
GO:BP	GO:0060341	regulation of cellular localization	443	776	3.47e-03
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	90	135	3.53e-03
GO:BP	GO:0009790	embryo development	467	821	3.55e-03
GO:BP	GO:0045598	regulation of fat cell differentiation	65	93	3.85e-03
GO:BP	GO:1902904	negative regulation of supramolecular fiber organization	84	125	3.86e-03
GO:BP	GO:0070482	response to oxygen levels	164	265	3.93e-03
GO:BP	GO:0000302	response to reactive oxygen species	102	156	4.01e-03
GO:BP	GO:0003176	aortic valve development	30	37	4.01e-03
GO:BP	GO:0060429	epithelium development	451	792	4.01e-03
GO:BP	GO:0043666	regulation of phosphoprotein phosphatase activity	28	34	4.05e-03
GO:BP	GO:0062197	cellular response to chemical stress	156	251	4.16e-03
GO:BP	GO:0003205	cardiac chamber development	99	151	4.25e-03
GO:BP	GO:0022407	regulation of cell-cell adhesion	171	278	4.40e-03
GO:BP	GO:0070727	cellular macromolecule localization	1092	2010	4.40e-03
GO:BP	GO:0006886	intracellular protein transport	342	590	4.41e-03
GO:BP	GO:0018193	peptidyl-amino acid modification	323	555	4.48e-03
GO:BP	GO:0052548	regulation of endopeptidase activity	100	153	4.64e-03
GO:BP	GO:0009056	catabolic process	1052	1934	4.69e-03
GO:BP	GO:0090304	nucleic acid metabolic process	2004	3777	4.75e-03
GO:BP	GO:0031331	positive regulation of cellular catabolic process	168	273	4.76e-03
GO:BP	GO:0043393	regulation of protein binding	76	112	4.76e-03
GO:BP	GO:0106106	cold-induced thermogenesis	76	112	4.76e-03
GO:BP	GO:0042060	wound healing	178	291	4.85e-03
GO:BP	GO:0051090	regulation of DNA-binding transcription factor activity	150	241	4.87e-03
GO:BP	GO:0030833	regulation of actin filament polymerization	70	102	4.98e-03
GO:BP	GO:0005975	carbohydrate metabolic process	242	407	4.98e-03
GO:BP	GO:0030903	notochord development	16	17	5.05e-03
GO:BP	GO:0045321	leukocyte activation	309	530	5.05e-03
GO:BP	GO:0060612	adipose tissue development	35	45	5.05e-03
GO:BP	GO:0060541	respiratory system development	105	162	5.07e-03
GO:BP	GO:0006986	response to unfolded protein	80	119	5.10e-03
GO:BP	GO:0007163	establishment or maintenance of cell polarity	117	183	5.16e-03
GO:BP	GO:2000737	negative regulation of stem cell differentiation	21	24	5.20e-03
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	2212	4185	5.27e-03
GO:BP	GO:0007179	transforming growth factor beta receptor signaling pathway	110	171	5.55e-03
GO:BP	GO:0032103	positive regulation of response to external stimulus	207	344	5.57e-03
GO:BP	GO:0050851	antigen receptor-mediated signaling pathway	71	104	5.61e-03
GO:BP	GO:0036294	cellular response to decreased oxygen levels	81	121	5.68e-03
GO:BP	GO:0010464	regulation of mesenchymal cell proliferation	23	27	5.79e-03
GO:BP	GO:0035886	vascular associated smooth muscle cell differentiation	23	27	5.79e-03
GO:BP	GO:0001933	negative regulation of protein phosphorylation	140	224	5.82e-03
GO:BP	GO:0043124	negative regulation of canonical NF-kappaB signal transduction	29	36	5.94e-03
GO:BP	GO:0000768	syncytium formation by plasma membrane fusion	29	36	5.94e-03
GO:BP	GO:0010463	mesenchymal cell proliferation	29	36	5.94e-03
GO:BP	GO:0140253	cell-cell fusion	29	36	5.94e-03
GO:BP	GO:0048008	platelet-derived growth factor receptor signaling pathway	38	50	6.05e-03
GO:BP	GO:0043085	positive regulation of catalytic activity	317	546	6.06e-03
GO:BP	GO:0000209	protein polyubiquitination	141	226	6.11e-03
GO:BP	GO:0045637	regulation of myeloid cell differentiation	89	135	6.23e-03
GO:BP	GO:0031401	positive regulation of protein modification process	319	550	6.36e-03
GO:BP	GO:0097696	receptor signaling pathway via STAT	63	91	6.68e-03
GO:BP	GO:0008104	protein localization	1084	2000	6.74e-03
GO:BP	GO:0007584	response to nutrient	76	113	6.83e-03
GO:BP	GO:0030032	lamellipodium assembly	41	55	6.97e-03
GO:BP	GO:0048193	Golgi vesicle transport	162	264	6.97e-03
GO:BP	GO:0061572	actin filament bundle organization	87	132	7.27e-03
GO:BP	GO:0043244	regulation of protein-containing complex disassembly	70	103	7.32e-03
GO:BP	GO:0002768	immune response-regulating cell surface receptor signaling pathway	106	165	7.36e-03
GO:BP	GO:0031344	regulation of cell projection organization	300	516	7.59e-03
GO:BP	GO:0055006	cardiac cell development	55	78	7.68e-03
GO:BP	GO:0003013	circulatory system process	251	426	7.76e-03
GO:BP	GO:0040013	negative regulation of locomotion	150	243	7.78e-03
GO:BP	GO:0046483	heterocycle metabolic process	2265	4295	7.81e-03
GO:BP	GO:0031396	regulation of protein ubiquitination	103	160	7.87e-03
GO:BP	GO:1905314	semi-lunar valve development	32	41	7.90e-03
GO:BP	GO:0010952	positive regulation of peptidase activity	71	105	8.22e-03
GO:BP	GO:1903580	positive regulation of ATP metabolic process	20	23	8.34e-03
GO:BP	GO:1902894	negative regulation of miRNA transcription	20	23	8.34e-03
GO:BP	GO:0002429	immune response-activating cell surface receptor signaling pathway	100	155	8.42e-03
GO:BP	GO:0072659	protein localization to plasma membrane	147	238	8.42e-03
GO:BP	GO:0006949	syncytium formation	30	38	8.45e-03
GO:BP	GO:0071474	cellular hyperosmotic response	15	16	8.50e-03
GO:BP	GO:1901879	regulation of protein depolymerization	50	70	8.52e-03
GO:BP	GO:0150115	cell-substrate junction organization	65	95	8.61e-03
GO:BP	GO:0090288	negative regulation of cellular response to growth factor stimulus	53	75	8.75e-03
GO:BP	GO:0051017	actin filament bundle assembly	86	131	9.19e-03
GO:BP	GO:0034614	cellular response to reactive oxygen species	79	119	9.31e-03
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	131	210	9.50e-03
GO:BP	GO:0045216	cell-cell junction organization	98	152	9.72e-03
GO:BP	GO:0007623	circadian rhythm	98	152	9.72e-03
GO:BP	GO:0033002	muscle cell proliferation	98	152	9.72e-03
GO:BP	GO:0071456	cellular response to hypoxia	76	114	9.74e-03
GO:BP	GO:0046822	regulation of nucleocytoplasmic transport	66	97	9.74e-03
GO:BP	GO:0043086	negative regulation of catalytic activity	180	298	9.76e-03
GO:BP	GO:0030182	neuron differentiation	565	1014	9.82e-03
GO:BP	GO:0098542	defense response to other organism	347	605	9.93e-03
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	293	505	1.01e-02
GO:BP	GO:0044409	symbiont entry into host	73	109	1.01e-02
GO:BP	GO:2000116	regulation of cysteine-type endopeptidase activity	80	121	1.02e-02
GO:BP	GO:0009267	cellular response to starvation	95	147	1.03e-02
GO:BP	GO:0040007	growth	396	697	1.08e-02
GO:BP	GO:0046777	protein autophosphorylation	92	142	1.11e-02
GO:BP	GO:0043242	negative regulation of protein-containing complex disassembly	46	64	1.12e-02
GO:BP	GO:0051258	protein polymerization	139	225	1.14e-02
GO:BP	GO:1901360	organic cyclic compound metabolic process	2346	4460	1.14e-02
GO:BP	GO:0070935	3’-UTR-mediated mRNA stabilization	17	19	1.15e-02
GO:BP	GO:0120162	positive regulation of cold-induced thermogenesis	49	69	1.15e-02
GO:BP	GO:0001659	temperature homeostasis	85	130	1.15e-02
GO:BP	GO:0060412	ventricular septum morphogenesis	31	40	1.15e-02
GO:BP	GO:0043500	muscle adaptation	61	89	1.15e-02
GO:BP	GO:0022008	neurogenesis	689	1251	1.18e-02
GO:BP	GO:0007249	canonical NF-kappaB signal transduction	140	227	1.18e-02
GO:BP	GO:1901880	negative regulation of protein depolymerization	41	56	1.20e-02
GO:BP	GO:0060537	muscle tissue development	202	339	1.20e-02
GO:BP	GO:0051058	negative regulation of small GTPase mediated signal transduction	36	48	1.22e-02
GO:BP	GO:0043408	regulation of MAPK cascade	250	427	1.23e-02
GO:BP	GO:0030866	cortical actin cytoskeleton organization	29	37	1.24e-02
GO:BP	GO:0051261	protein depolymerization	65	96	1.26e-02
GO:BP	GO:0048568	embryonic organ development	182	303	1.28e-02
GO:BP	GO:0098781	ncRNA transcription	79	120	1.29e-02
GO:BP	GO:0045639	positive regulation of myeloid cell differentiation	47	66	1.32e-02
GO:BP	GO:0042110	T cell activation	183	305	1.33e-02
GO:BP	GO:0010634	positive regulation of epithelial cell migration	83	127	1.33e-02
GO:BP	GO:0042594	response to starvation	111	176	1.34e-02
GO:BP	GO:0010035	response to inorganic substance	223	378	1.34e-02
GO:BP	GO:0046718	symbiont entry into host cell	69	103	1.35e-02
GO:BP	GO:0030865	cortical cytoskeleton organization	34	45	1.35e-02
GO:BP	GO:0003231	cardiac ventricle development	76	115	1.35e-02
GO:BP	GO:0002831	regulation of response to biotic stimulus	184	307	1.36e-02
GO:BP	GO:1900744	regulation of p38MAPK cascade	25	31	1.37e-02
GO:BP	GO:2000146	negative regulation of cell motility	134	217	1.38e-02
GO:BP	GO:0045981	positive regulation of nucleotide metabolic process	21	25	1.38e-02
GO:BP	GO:0075294	positive regulation by symbiont of entry into host	11	11	1.38e-02
GO:BP	GO:2000629	negative regulation of miRNA metabolic process	21	25	1.38e-02
GO:BP	GO:0046598	positive regulation of viral entry into host cell	11	11	1.38e-02
GO:BP	GO:1900544	positive regulation of purine nucleotide metabolic process	21	25	1.38e-02
GO:BP	GO:0048738	cardiac muscle tissue development	125	201	1.38e-02
GO:BP	GO:0060317	cardiac epithelial to mesenchymal transition	23	28	1.39e-02
GO:BP	GO:0003206	cardiac chamber morphogenesis	73	110	1.40e-02
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	269	463	1.41e-02
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	269	463	1.41e-02
GO:BP	GO:0030336	negative regulation of cell migration	130	210	1.41e-02
GO:BP	GO:0022411	cellular component disassembly	250	428	1.41e-02
GO:BP	GO:0009755	hormone-mediated signaling pathway	88	136	1.43e-02
GO:BP	GO:0007259	receptor signaling pathway via JAK-STAT	60	88	1.47e-02
GO:BP	GO:0007044	cell-substrate junction assembly	60	88	1.47e-02
GO:BP	GO:0006952	defense response	512	918	1.49e-02
GO:BP	GO:2000630	positive regulation of miRNA metabolic process	37	50	1.49e-02
GO:BP	GO:0048511	rhythmic process	136	221	1.49e-02
GO:BP	GO:0071824	protein-DNA complex organization	387	683	1.49e-02
GO:BP	GO:0030041	actin filament polymerization	81	124	1.49e-02
GO:BP	GO:0010975	regulation of neuron projection development	210	355	1.49e-02
GO:BP	GO:0019915	lipid storage	48	68	1.50e-02
GO:BP	GO:0043502	regulation of muscle adaptation	48	68	1.50e-02
GO:BP	GO:0003158	endothelium development	67	100	1.51e-02
GO:BP	GO:0030856	regulation of epithelial cell differentiation	67	100	1.51e-02
GO:BP	GO:0051495	positive regulation of cytoskeleton organization	93	145	1.54e-02
GO:BP	GO:0031347	regulation of defense response	261	449	1.56e-02
GO:BP	GO:0055082	intracellular chemical homeostasis	281	486	1.57e-02
GO:BP	GO:0008284	positive regulation of cell population proliferation	345	605	1.58e-02
GO:BP	GO:0051145	smooth muscle cell differentiation	40	55	1.59e-02
GO:BP	GO:0016032	viral process	195	328	1.59e-02
GO:BP	GO:0007009	plasma membrane organization	71	107	1.59e-02
GO:BP	GO:0001952	regulation of cell-matrix adhesion	61	90	1.63e-02
GO:BP	GO:0071453	cellular response to oxygen levels	86	133	1.63e-02
GO:BP	GO:0050767	regulation of neurogenesis	174	290	1.65e-02
GO:BP	GO:0071702	organic substance transport	933	1722	1.68e-02
GO:BP	GO:0007159	leukocyte cell-cell adhesion	134	218	1.69e-02
GO:BP	GO:0006725	cellular aromatic compound metabolic process	2267	4313	1.69e-02
GO:BP	GO:0006900	vesicle budding from membrane	52	75	1.74e-02
GO:BP	GO:0085029	extracellular matrix assembly	28	36	1.74e-02
GO:BP	GO:0048660	regulation of smooth muscle cell proliferation	65	97	1.75e-02
GO:BP	GO:0050878	regulation of body fluid levels	140	229	1.78e-02
GO:BP	GO:0006979	response to oxidative stress	182	305	1.80e-02
GO:BP	GO:0001501	skeletal system development	205	347	1.81e-02
GO:BP	GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	76	116	1.81e-02
GO:BP	GO:0009057	macromolecule catabolic process	598	1083	1.82e-02
GO:BP	GO:1902895	positive regulation of miRNA transcription	33	44	1.85e-02
GO:BP	GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	80	123	1.85e-02
GO:BP	GO:0038066	p38MAPK cascade	33	44	1.85e-02
GO:BP	GO:0003180	aortic valve morphogenesis	26	33	1.87e-02
GO:BP	GO:0050801	monoatomic ion homeostasis	237	406	1.88e-02
GO:BP	GO:0006402	mRNA catabolic process	127	206	1.89e-02
GO:BP	GO:0010608	post-transcriptional regulation of gene expression	264	456	1.94e-02
GO:BP	GO:0003208	cardiac ventricle morphogenesis	44	62	1.97e-02
GO:BP	GO:0033043	regulation of organelle organization	529	953	1.98e-02
GO:BP	GO:1903828	negative regulation of protein localization	101	160	1.98e-02
GO:BP	GO:0061013	regulation of mRNA catabolic process	101	160	1.98e-02
GO:BP	GO:0043488	regulation of mRNA stability	93	146	2.02e-02
GO:BP	GO:0055080	monoatomic cation homeostasis	234	401	2.05e-02
GO:BP	GO:1904385	cellular response to angiotensin	22	27	2.05e-02
GO:BP	GO:0051098	regulation of binding	124	201	2.05e-02
GO:BP	GO:0043122	regulation of canonical NF-kappaB signal transduction	124	201	2.05e-02
GO:BP	GO:0072538	T-helper 17 type immune response	22	27	2.05e-02
GO:BP	GO:0034655	nucleobase-containing compound catabolic process	242	416	2.13e-02
GO:BP	GO:0097190	apoptotic signaling pathway	269	466	2.16e-02
GO:BP	GO:0051651	maintenance of location in cell	107	171	2.19e-02
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	284	494	2.22e-02
GO:BP	GO:0048732	gland development	183	308	2.23e-02
GO:BP	GO:0010950	positive regulation of endopeptidase activity	64	96	2.23e-02
GO:BP	GO:0006913	nucleocytoplasmic transport	172	288	2.23e-02
GO:BP	GO:0051169	nuclear transport	172	288	2.23e-02
GO:BP	GO:0031397	negative regulation of protein ubiquitination	42	59	2.25e-02
GO:BP	GO:0035304	regulation of protein dephosphorylation	42	59	2.25e-02
GO:BP	GO:1903708	positive regulation of hemopoiesis	75	115	2.26e-02
GO:BP	GO:1902107	positive regulation of leukocyte differentiation	75	115	2.26e-02
GO:BP	GO:1901203	positive regulation of extracellular matrix assembly	13	14	2.28e-02
GO:BP	GO:1903321	negative regulation of protein modification by small protein conjugation or removal	48	69	2.28e-02
GO:BP	GO:0048858	cell projection morphogenesis	286	498	2.28e-02
GO:BP	GO:0034260	negative regulation of GTPase activity	13	14	2.28e-02
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	252	435	2.28e-02
GO:BP	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	79	122	2.28e-02
GO:BP	GO:0007267	cell-cell signaling	596	1082	2.35e-02
GO:BP	GO:0034976	response to endoplasmic reticulum stress	113	182	2.35e-02
GO:BP	GO:0044030	regulation of DNA methylation	10	10	2.35e-02
GO:BP	GO:2000479	regulation of cAMP-dependent protein kinase activity	10	10	2.35e-02
GO:BP	GO:0034599	cellular response to oxidative stress	123	200	2.43e-02
GO:BP	GO:0045667	regulation of osteoblast differentiation	65	98	2.44e-02
GO:BP	GO:0051346	negative regulation of hydrolase activity	76	117	2.44e-02
GO:BP	GO:0042113	B cell activation	101	161	2.54e-02
GO:BP	GO:1903320	regulation of protein modification by small protein conjugation or removal	124	202	2.55e-02
GO:BP	GO:0048708	astrocyte differentiation	40	56	2.57e-02
GO:BP	GO:0007517	muscle organ development	160	267	2.57e-02
GO:BP	GO:0030514	negative regulation of BMP signaling pathway	32	43	2.57e-02
GO:BP	GO:0007369	gastrulation	89	140	2.66e-02
GO:BP	GO:0050920	regulation of chemotaxis	85	133	2.67e-02
GO:BP	GO:0048589	developmental growth	287	501	2.67e-02
GO:BP	GO:0002062	chondrocyte differentiation	59	88	2.68e-02
GO:BP	GO:0032386	regulation of intracellular transport	135	222	2.68e-02
GO:BP	GO:0002833	positive regulation of response to biotic stimulus	130	213	2.68e-02
GO:BP	GO:0010632	regulation of epithelial cell migration	116	188	2.73e-02
GO:BP	GO:1903037	regulation of leukocyte cell-cell adhesion	121	197	2.77e-02
GO:BP	GO:0034641	cellular nitrogen compound metabolic process	2432	4646	2.77e-02
GO:BP	GO:0050852	T cell receptor signaling pathway	56	83	2.77e-02
GO:BP	GO:0030162	regulation of proteolysis	241	416	2.77e-02
GO:BP	GO:0008015	blood circulation	209	357	2.77e-02
GO:BP	GO:0043549	regulation of kinase activity	209	357	2.77e-02
GO:BP	GO:0030042	actin filament depolymerization	35	48	2.77e-02
GO:BP	GO:0010718	positive regulation of epithelial to mesenchymal transition	35	48	2.77e-02
GO:BP	GO:0010811	positive regulation of cell-substrate adhesion	63	95	2.79e-02
GO:BP	GO:0071219	cellular response to molecule of bacterial origin	74	114	2.79e-02
GO:BP	GO:0009628	response to abiotic stimulus	452	811	2.80e-02
GO:BP	GO:0003215	cardiac right ventricle morphogenesis	15	17	2.80e-02
GO:BP	GO:0009166	nucleotide catabolic process	86	135	2.81e-02
GO:BP	GO:0007409	axonogenesis	198	337	2.84e-02
GO:BP	GO:0034620	cellular response to unfolded protein	53	78	2.84e-02
GO:BP	GO:0035305	negative regulation of dephosphorylation	23	29	2.86e-02
GO:BP	GO:1990776	response to angiotensin	23	29	2.86e-02
GO:BP	GO:0043542	endothelial cell migration	108	174	2.86e-02
GO:BP	GO:0003279	cardiac septum development	67	102	2.87e-02
GO:BP	GO:0045814	negative regulation of gene expression, epigenetic	67	102	2.87e-02
GO:BP	GO:0048524	positive regulation of viral process	38	53	2.87e-02
GO:BP	GO:0043401	steroid hormone mediated signaling pathway	71	109	2.95e-02
GO:BP	GO:0042176	regulation of protein catabolic process	176	297	2.96e-02
GO:BP	GO:0032880	regulation of protein localization	388	691	2.96e-02
GO:BP	GO:0048710	regulation of astrocyte differentiation	17	20	3.03e-02
GO:BP	GO:0045446	endothelial cell differentiation	57	85	3.03e-02
GO:BP	GO:0001783	B cell apoptotic process	17	20	3.03e-02
GO:BP	GO:0045088	regulation of innate immune response	149	248	3.03e-02
GO:BP	GO:0002053	positive regulation of mesenchymal cell proliferation	17	20	3.03e-02
GO:BP	GO:0019221	cytokine-mediated signaling pathway	160	268	3.03e-02
GO:BP	GO:0046700	heterocycle catabolic process	253	439	3.05e-02
GO:BP	GO:0090077	foam cell differentiation	19	23	3.06e-02
GO:BP	GO:0010742	macrophage derived foam cell differentiation	19	23	3.06e-02
GO:BP	GO:0018209	peptidyl-serine modification	105	169	3.07e-02
GO:BP	GO:0007160	cell-matrix adhesion	105	169	3.07e-02
GO:BP	GO:0009792	embryo development ending in birth or egg hatching	297	521	3.11e-02
GO:BP	GO:0051130	positive regulation of cellular component organization	472	850	3.11e-02
GO:BP	GO:0019725	cellular homeostasis	320	564	3.12e-02
GO:BP	GO:1902305	regulation of sodium ion transmembrane transport	28	37	3.13e-02
GO:BP	GO:0009261	ribonucleotide catabolic process	72	111	3.16e-02
GO:BP	GO:0019058	viral life cycle	140	232	3.18e-02
GO:BP	GO:0031333	negative regulation of protein-containing complex assembly	76	118	3.18e-02
GO:BP	GO:0030100	regulation of endocytosis	120	196	3.19e-02
GO:BP	GO:1901575	organic substance catabolic process	845	1562	3.20e-02
GO:BP	GO:0070527	platelet aggregation	36	50	3.25e-02
GO:BP	GO:0010660	regulation of muscle cell apoptotic process	36	50	3.25e-02
GO:BP	GO:0097193	intrinsic apoptotic signaling pathway	152	254	3.33e-02
GO:BP	GO:0006611	protein export from nucleus	39	55	3.35e-02
GO:BP	GO:0009154	purine ribonucleotide catabolic process	69	106	3.36e-02
GO:BP	GO:0043547	positive regulation of GTPase activity	73	113	3.41e-02
GO:BP	GO:0010256	endomembrane system organization	273	477	3.41e-02
GO:BP	GO:0043009	chordate embryonic development	289	507	3.50e-02
GO:BP	GO:0044403	biological process involved in symbiotic interaction	127	209	3.50e-02
GO:BP	GO:0022409	positive regulation of cell-cell adhesion	108	175	3.57e-02
GO:BP	GO:0048659	smooth muscle cell proliferation	66	101	3.58e-02
GO:BP	GO:0001101	response to acid chemical	66	101	3.58e-02
GO:BP	GO:0019439	aromatic compound catabolic process	255	444	3.64e-02
GO:BP	GO:0031623	receptor internalization	59	89	3.67e-02
GO:BP	GO:0048385	regulation of retinoic acid receptor signaling pathway	12	13	3.67e-02
GO:BP	GO:0060841	venous blood vessel development	12	13	3.67e-02
GO:BP	GO:1903729	regulation of plasma membrane organization	12	13	3.67e-02
GO:BP	GO:0140546	defense response to symbiont	315	556	3.67e-02
GO:BP	GO:0003174	mitral valve development	12	13	3.67e-02
GO:BP	GO:0045600	positive regulation of fat cell differentiation	34	47	3.70e-02
GO:BP	GO:0014743	regulation of muscle hypertrophy	34	47	3.70e-02
GO:BP	GO:0055013	cardiac muscle cell development	49	72	3.71e-02
GO:BP	GO:0071229	cellular response to acid chemical	49	72	3.71e-02
GO:BP	GO:0019318	hexose metabolic process	109	177	3.71e-02
GO:BP	GO:0061564	axon development	216	372	3.72e-02
GO:BP	GO:0032984	protein-containing complex disassembly	129	213	3.75e-02
GO:BP	GO:0014706	striated muscle tissue development	129	213	3.75e-02
GO:BP	GO:0018105	peptidyl-serine phosphorylation	100	161	3.75e-02
GO:BP	GO:0031349	positive regulation of defense response	156	262	3.76e-02
GO:BP	GO:0030857	negative regulation of epithelial cell differentiation	24	31	3.77e-02
GO:BP	GO:0060411	cardiac septum morphogenesis	46	67	3.78e-02
GO:BP	GO:0072089	stem cell proliferation	56	84	3.79e-02
GO:BP	GO:1904063	negative regulation of cation transmembrane transport	37	52	3.79e-02
GO:BP	GO:0048545	response to steroid hormone	140	233	3.80e-02
GO:BP	GO:0072331	signal transduction by p53 class mediator	96	154	3.84e-02
GO:BP	GO:0035108	limb morphogenesis	71	110	3.87e-02
GO:BP	GO:0035107	appendage morphogenesis	71	110	3.87e-02
GO:BP	GO:0042330	taxis	146	244	3.87e-02
GO:BP	GO:0006935	chemotaxis	146	244	3.87e-02
GO:BP	GO:0042327	positive regulation of phosphorylation	239	415	3.92e-02
GO:BP	GO:0030163	protein catabolic process	440	792	3.93e-02
GO:BP	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	9	9	3.93e-02
GO:BP	GO:0090336	positive regulation of brown fat cell differentiation	9	9	3.93e-02
GO:BP	GO:0030038	contractile actin filament bundle assembly	60	91	3.93e-02
GO:BP	GO:0048845	venous blood vessel morphogenesis	9	9	3.93e-02
GO:BP	GO:0043149	stress fiber assembly	60	91	3.93e-02
GO:BP	GO:1901298	regulation of hydrogen peroxide-mediated programmed cell death	9	9	3.93e-02
GO:BP	GO:0001765	membrane raft assembly	9	9	3.93e-02
GO:BP	GO:1901292	nucleoside phosphate catabolic process	88	140	3.97e-02
GO:BP	GO:0033673	negative regulation of kinase activity	84	133	4.03e-02
GO:BP	GO:0003171	atrioventricular valve development	22	28	4.03e-02
GO:BP	GO:0098876	vesicle-mediated transport to the plasma membrane	84	133	4.03e-02
GO:BP	GO:0010591	regulation of lamellipodium assembly	22	28	4.03e-02
GO:BP	GO:0032456	endocytic recycling	50	74	4.06e-02
GO:BP	GO:0055007	cardiac muscle cell differentiation	68	105	4.07e-02
GO:BP	GO:1905039	carboxylic acid transmembrane transport	68	105	4.07e-02
GO:BP	GO:0072523	purine-containing compound catabolic process	76	119	4.10e-02
GO:BP	GO:0034332	adherens junction organization	32	44	4.11e-02
GO:BP	GO:0030217	T cell differentiation	112	183	4.16e-02
GO:BP	GO:0071901	negative regulation of protein serine/threonine kinase activity	47	69	4.19e-02
GO:BP	GO:0032273	positive regulation of protein polymerization	47	69	4.19e-02
GO:BP	GO:0044270	cellular nitrogen compound catabolic process	250	436	4.19e-02
GO:BP	GO:0048644	muscle organ morphogenesis	44	64	4.24e-02
GO:BP	GO:0048812	neuron projection morphogenesis	273	479	4.24e-02
GO:BP	GO:0048662	negative regulation of smooth muscle cell proliferation	27	36	4.24e-02
GO:BP	GO:0048699	generation of neurons	589	1076	4.24e-02
GO:BP	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	20	25	4.24e-02
GO:BP	GO:0072111	cell proliferation involved in kidney development	14	16	4.24e-02
GO:BP	GO:0038095	Fc-epsilon receptor signaling pathway	14	16	4.24e-02
GO:BP	GO:0040029	epigenetic regulation of gene expression	103	167	4.24e-02
GO:BP	GO:0032092	positive regulation of protein binding	35	49	4.24e-02
GO:BP	GO:0043069	negative regulation of programmed cell death	360	642	4.24e-02
GO:BP	GO:0071320	cellular response to cAMP	27	36	4.24e-02
GO:BP	GO:0046323	glucose import	38	54	4.29e-02
GO:BP	GO:0005996	monosaccharide metabolic process	118	194	4.29e-02
GO:BP	GO:0048729	tissue morphogenesis	259	453	4.29e-02
GO:BP	GO:0014910	regulation of smooth muscle cell migration	38	54	4.29e-02
GO:BP	GO:0034766	negative regulation of monoatomic ion transmembrane transport	41	59	4.29e-02
GO:BP	GO:0006195	purine nucleotide catabolic process	73	114	4.34e-02
GO:BP	GO:0006006	glucose metabolic process	90	144	4.36e-02
GO:BP	GO:0035767	endothelial cell chemotaxis	18	22	4.42e-02
GO:BP	GO:0018210	peptidyl-threonine modification	51	76	4.45e-02
GO:BP	GO:1990778	protein localization to cell periphery	169	287	4.53e-02
GO:BP	GO:0045862	positive regulation of proteolysis	146	245	4.54e-02
GO:BP	GO:0019722	calcium-mediated signaling	78	123	4.62e-02
GO:BP	GO:0051701	biological process involved in interaction with host	91	146	4.62e-02
GO:BP	GO:1901873	regulation of post-translational protein modification	125	207	4.63e-02
GO:BP	GO:0055085	transmembrane transport	507	921	4.64e-02
GO:BP	GO:0060048	cardiac muscle contraction	74	116	4.65e-02
GO:BP	GO:0001889	liver development	70	109	4.65e-02
GO:BP	GO:0090263	positive regulation of canonical Wnt signaling pathway	55	83	4.67e-02
GO:BP	GO:2001056	positive regulation of cysteine-type endopeptidase activity	55	83	4.67e-02
GO:BP	GO:0001503	ossification	177	302	4.76e-02
GO:BP	GO:0043933	protein-containing complex organization	998	1863	4.82e-02
GO:BP	GO:0035051	cardiocyte differentiation	83	132	4.82e-02
GO:BP	GO:0060350	endochondral bone morphogenesis	33	46	4.83e-02
GO:BP	GO:0010611	regulation of cardiac muscle hypertrophy	33	46	4.83e-02
GO:BP	GO:0010721	negative regulation of cell development	111	182	4.84e-02
GO:BP	GO:0048705	skeletal system morphogenesis	92	148	4.84e-02
GO:BP	GO:0060415	muscle tissue morphogenesis	42	61	4.86e-02
GO:BP	GO:0072091	regulation of stem cell proliferation	42	61	4.86e-02
GO:BP	GO:0050770	regulation of axonogenesis	79	125	4.88e-02
GO:BP	GO:0030510	regulation of BMP signaling pathway	52	78	4.88e-02
GO:BP	GO:0030518	intracellular steroid hormone receptor signaling pathway	63	97	4.91e-02
GO:BP	GO:0071772	response to BMP	75	118	4.92e-02
GO:BP	GO:0071773	cellular response to BMP stimulus	75	118	4.92e-02
GO:BP	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	67	104	4.94e-02
GO:BP	GO:0002520	immune system development	88	141	4.94e-02
GO:BP	GO:0002218	activation of innate immune response	102	166	4.97e-02
GO:BP	GO:0043632	modification-dependent macromolecule catabolic process	299	529	4.98e-02

NRnomtable_20k_enh %>%
  filter(source=="KEGG", p_value < 0.05) %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "KEGG terms found in NR enhancer neargenes_20k") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

KEGG terms found in NR enhancer neargenes_20k

source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:00000	KEGG root term	2946	5451	2.10e-09
KEGG	KEGG:04659	Th17 cell differentiation	51	60	4.20e-06
KEGG	KEGG:05200	Pathways in cancer	249	391	9.31e-06
KEGG	KEGG:04510	Focal adhesion	114	169	5.20e-04
KEGG	KEGG:04380	Osteoclast differentiation	67	92	7.50e-04
KEGG	KEGG:04072	Phospholipase D signaling pathway	76	107	7.50e-04
KEGG	KEGG:04931	Insulin resistance	66	91	7.86e-04
KEGG	KEGG:04148	Efferocytosis	83	120	1.15e-03
KEGG	KEGG:04390	Hippo signaling pathway	88	129	1.18e-03
KEGG	KEGG:05135	Yersinia infection	75	107	1.18e-03
KEGG	KEGG:05100	Bacterial invasion of epithelial cells	54	73	1.18e-03
KEGG	KEGG:04630	JAK-STAT signaling pathway	60	83	1.30e-03
KEGG	KEGG:04910	Insulin signaling pathway	78	113	1.32e-03
KEGG	KEGG:05131	Shigellosis	131	204	1.32e-03
KEGG	KEGG:04658	Th1 and Th2 cell differentiation	39	50	1.45e-03
KEGG	KEGG:04550	Signaling pathways regulating pluripotency of stem cells	70	101	2.19e-03
KEGG	KEGG:04917	Prolactin signaling pathway	41	54	2.34e-03
KEGG	KEGG:04520	Adherens junction	59	83	2.34e-03
KEGG	KEGG:05167	Kaposi sarcoma-associated herpesvirus infection	89	134	2.65e-03
KEGG	KEGG:04933	AGE-RAGE signaling pathway in diabetic complications	61	87	2.78e-03
KEGG	KEGG:05205	Proteoglycans in cancer	105	162	2.78e-03
KEGG	KEGG:04310	Wnt signaling pathway	88	133	3.05e-03
KEGG	KEGG:04935	Growth hormone synthesis, secretion and action	66	96	3.46e-03
KEGG	KEGG:05163	Human cytomegalovirus infection	103	160	4.09e-03
KEGG	KEGG:05231	Choline metabolism in cancer	56	80	4.20e-03
KEGG	KEGG:05130	Pathogenic Escherichia coli infection	93	143	4.20e-03
KEGG	KEGG:04350	TGF-beta signaling pathway	62	90	4.20e-03
KEGG	KEGG:04062	Chemokine signaling pathway	73	109	4.75e-03
KEGG	KEGG:04722	Neurotrophin signaling pathway	70	104	4.81e-03
KEGG	KEGG:05225	Hepatocellular carcinoma	89	137	5.21e-03
KEGG	KEGG:05206	MicroRNAs in cancer	93	144	5.21e-03
KEGG	KEGG:04010	MAPK signaling pathway	142	231	5.57e-03
KEGG	KEGG:04066	HIF-1 signaling pathway	59	86	5.57e-03
KEGG	KEGG:04015	Rap1 signaling pathway	103	162	5.63e-03
KEGG	KEGG:04934	Cushing syndrome	78	119	6.70e-03
KEGG	KEGG:04662	B cell receptor signaling pathway	38	52	7.71e-03
KEGG	KEGG:05132	Salmonella infection	124	201	8.78e-03
KEGG	KEGG:04152	AMPK signaling pathway	67	101	8.92e-03
KEGG	KEGG:04625	C-type lectin receptor signaling pathway	51	74	9.41e-03
KEGG	KEGG:04926	Relaxin signaling pathway	66	100	1.13e-02
KEGG	KEGG:05170	Human immunodeficiency virus 1 infection	94	149	1.16e-02
KEGG	KEGG:04360	Axon guidance	97	155	1.28e-02
KEGG	KEGG:04657	IL-17 signaling pathway	39	55	1.28e-02
KEGG	KEGG:04810	Regulation of actin cytoskeleton	105	169	1.28e-02
KEGG	KEGG:05226	Gastric cancer	73	113	1.28e-02
KEGG	KEGG:05166	Human T-cell leukemia virus 1 infection	102	164	1.28e-02
KEGG	KEGG:03083	Polycomb repressive complex	48	70	1.28e-02
KEGG	KEGG:04151	PI3K-Akt signaling pathway	150	250	1.28e-02
KEGG	KEGG:04217	Necroptosis	65	99	1.28e-02
KEGG	KEGG:04664	Fc epsilon RI signaling pathway	31	42	1.29e-02
KEGG	KEGG:05417	Lipid and atherosclerosis	90	143	1.29e-02
KEGG	KEGG:05220	Chronic myeloid leukemia	49	72	1.35e-02
KEGG	KEGG:04660	T cell receptor signaling pathway	56	84	1.37e-02
KEGG	KEGG:04730	Long-term depression	29	39	1.38e-02
KEGG	KEGG:03082	ATP-dependent chromatin remodeling	60	91	1.39e-02
KEGG	KEGG:04340	Hedgehog signaling pathway	35	49	1.47e-02
KEGG	KEGG:04920	Adipocytokine signaling pathway	35	49	1.47e-02
KEGG	KEGG:05210	Colorectal cancer	54	81	1.47e-02
KEGG	KEGG:04392	Hippo signaling pathway - multiple species	20	25	1.47e-02
KEGG	KEGG:04144	Endocytosis	130	216	1.58e-02
KEGG	KEGG:04014	Ras signaling pathway	101	164	1.64e-02
KEGG	KEGG:04921	Oxytocin signaling pathway	72	113	1.81e-02
KEGG	KEGG:05224	Breast cancer	72	113	1.81e-02
KEGG	KEGG:04218	Cellular senescence	85	136	1.81e-02
KEGG	KEGG:04012	ErbB signaling pathway	50	75	1.81e-02
KEGG	KEGG:05202	Transcriptional misregulation in cancer	77	122	1.81e-02
KEGG	KEGG:04150	mTOR signaling pathway	81	129	1.81e-02
KEGG	KEGG:04666	Fc gamma R-mediated phagocytosis	50	75	1.81e-02
KEGG	KEGG:04141	Protein processing in endoplasmic reticulum	92	149	1.96e-02
KEGG	KEGG:05145	Toxoplasmosis	48	72	2.11e-02
KEGG	KEGG:05211	Renal cell carcinoma	42	62	2.30e-02
KEGG	KEGG:04330	Notch signaling pathway	36	52	2.34e-02
KEGG	KEGG:04710	Circadian rhythm	22	29	2.34e-02
KEGG	KEGG:04611	Platelet activation	57	88	2.34e-02
KEGG	KEGG:05418	Fluid shear stress and atherosclerosis	69	109	2.34e-02
KEGG	KEGG:04022	cGMP-PKG signaling pathway	80	129	2.65e-02
KEGG	KEGG:04068	FoxO signaling pathway	67	106	2.67e-02
KEGG	KEGG:04919	Thyroid hormone signaling pathway	66	105	3.35e-02
KEGG	KEGG:04979	Cholesterol metabolism	24	33	3.63e-02
KEGG	KEGG:01521	EGFR tyrosine kinase inhibitor resistance	47	72	3.66e-02
KEGG	KEGG:05412	Arrhythmogenic right ventricular cardiomyopathy	44	67	3.90e-02
KEGG	KEGG:04915	Estrogen signaling pathway	57	90	4.26e-02
KEGG	KEGG:04070	Phosphatidylinositol signaling system	53	83	4.26e-02
KEGG	KEGG:05161	Hepatitis B	77	126	4.51e-02
KEGG	KEGG:04928	Parathyroid hormone synthesis, secretion and action	50	78	4.51e-02
KEGG	KEGG:05212	Pancreatic cancer	46	71	4.51e-02

Session information

sessionInfo()

R version 4.3.1 (2023-06-16 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)

Matrix products: default


locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

time zone: America/Chicago
tzcode source: internal

attached base packages:
[1] grid      stats4    stats     graphics  grDevices utils     datasets 
[8] methods   base     

other attached packages:
 [1] biomaRt_2.58.2                          
 [2] ggpubr_0.6.0                            
 [3] BiocParallel_1.36.0                     
 [4] scales_1.3.0                            
 [5] VennDiagram_1.7.3                       
 [6] futile.logger_1.4.3                     
 [7] gridExtra_2.3                           
 [8] ggfortify_0.4.17                        
 [9] edgeR_4.0.16                            
[10] limma_3.58.1                            
[11] rtracklayer_1.62.0                      
[12] org.Hs.eg.db_3.18.0                     
[13] TxDb.Hsapiens.UCSC.hg38.knownGene_3.18.0
[14] GenomicFeatures_1.54.4                  
[15] AnnotationDbi_1.64.1                    
[16] Biobase_2.62.0                          
[17] GenomicRanges_1.54.1                    
[18] GenomeInfoDb_1.38.8                     
[19] IRanges_2.36.0                          
[20] S4Vectors_0.40.2                        
[21] BiocGenerics_0.48.1                     
[22] ChIPseeker_1.38.0                       
[23] gprofiler2_0.2.3                        
[24] RColorBrewer_1.1-3                      
[25] broom_1.0.6                             
[26] kableExtra_1.4.0                        
[27] lubridate_1.9.3                         
[28] forcats_1.0.0                           
[29] stringr_1.5.1                           
[30] dplyr_1.1.4                             
[31] purrr_1.0.2                             
[32] readr_2.1.5                             
[33] tidyr_1.3.1                             
[34] tibble_3.2.1                            
[35] ggplot2_3.5.1                           
[36] tidyverse_2.0.0                         
[37] workflowr_1.7.1                         

loaded via a namespace (and not attached):
  [1] fs_1.6.4                               
  [2] matrixStats_1.3.0                      
  [3] bitops_1.0-7                           
  [4] enrichplot_1.22.0                      
  [5] HDO.db_0.99.1                          
  [6] httr_1.4.7                             
  [7] tools_4.3.1                            
  [8] backports_1.4.1                        
  [9] utf8_1.2.4                             
 [10] R6_2.5.1                               
 [11] lazyeval_0.2.2                         
 [12] withr_3.0.0                            
 [13] prettyunits_1.2.0                      
 [14] cli_3.6.2                              
 [15] formatR_1.14                           
 [16] scatterpie_0.2.2                       
 [17] labeling_0.4.3                         
 [18] sass_0.4.9                             
 [19] Rsamtools_2.18.0                       
 [20] systemfonts_1.1.0                      
 [21] yulab.utils_0.1.4                      
 [22] DOSE_3.28.2                            
 [23] svglite_2.1.3                          
 [24] plotrix_3.8-4                          
 [25] rstudioapi_0.16.0                      
 [26] RSQLite_2.3.6                          
 [27] generics_0.1.3                         
 [28] gridGraphics_0.5-1                     
 [29] TxDb.Hsapiens.UCSC.hg19.knownGene_3.2.2
 [30] BiocIO_1.12.0                          
 [31] crosstalk_1.2.1                        
 [32] vroom_1.6.5                            
 [33] gtools_3.9.5                           
 [34] car_3.1-2                              
 [35] GO.db_3.18.0                           
 [36] Matrix_1.6-5                           
 [37] fansi_1.0.6                            
 [38] abind_1.4-5                            
 [39] lifecycle_1.0.4                        
 [40] whisker_0.4.1                          
 [41] yaml_2.3.8                             
 [42] carData_3.0-5                          
 [43] SummarizedExperiment_1.32.0            
 [44] gplots_3.1.3.1                         
 [45] qvalue_2.34.0                          
 [46] SparseArray_1.2.4                      
 [47] BiocFileCache_2.10.2                   
 [48] blob_1.2.4                             
 [49] promises_1.3.0                         
 [50] crayon_1.5.2                           
 [51] lattice_0.22-6                         
 [52] cowplot_1.1.3                          
 [53] KEGGREST_1.42.0                        
 [54] pillar_1.9.0                           
 [55] knitr_1.46                             
 [56] fgsea_1.28.0                           
 [57] rjson_0.2.21                           
 [58] boot_1.3-30                            
 [59] codetools_0.2-20                       
 [60] fastmatch_1.1-4                        
 [61] glue_1.7.0                             
 [62] getPass_0.2-4                          
 [63] ggfun_0.1.4                            
 [64] data.table_1.15.4                      
 [65] vctrs_0.6.5                            
 [66] png_0.1-8                              
 [67] treeio_1.26.0                          
 [68] gtable_0.3.5                           
 [69] cachem_1.1.0                           
 [70] xfun_0.44                              
 [71] S4Arrays_1.2.1                         
 [72] mime_0.12                              
 [73] tidygraph_1.3.1                        
 [74] statmod_1.5.0                          
 [75] interactiveDisplayBase_1.40.0          
 [76] nlme_3.1-164                           
 [77] ggtree_3.10.1                          
 [78] bit64_4.0.5                            
 [79] progress_1.2.3                         
 [80] filelock_1.0.3                         
 [81] rprojroot_2.0.4                        
 [82] bslib_0.7.0                            
 [83] KernSmooth_2.23-24                     
 [84] colorspace_2.1-0                       
 [85] DBI_1.2.2                              
 [86] tidyselect_1.2.1                       
 [87] processx_3.8.4                         
 [88] bit_4.0.5                              
 [89] compiler_4.3.1                         
 [90] curl_5.2.1                             
 [91] git2r_0.33.0                           
 [92] xml2_1.3.6                             
 [93] DelayedArray_0.28.0                    
 [94] plotly_4.10.4                          
 [95] shadowtext_0.1.3                       
 [96] caTools_1.18.2                         
 [97] callr_3.7.6                            
 [98] rappdirs_0.3.3                         
 [99] digest_0.6.35                          
[100] rmarkdown_2.27                         
[101] XVector_0.42.0                         
[102] htmltools_0.5.8.1                      
[103] pkgconfig_2.0.3                        
[104] MatrixGenerics_1.14.0                  
[105] highr_0.10                             
[106] dbplyr_2.5.0                           
[107] fastmap_1.2.0                          
[108] rlang_1.1.3                            
[109] htmlwidgets_1.6.4                      
[110] shiny_1.8.1.1                          
[111] farver_2.1.2                           
[112] jquerylib_0.1.4                        
[113] jsonlite_1.8.8                         
[114] GOSemSim_2.28.1                        
[115] RCurl_1.98-1.14                        
[116] magrittr_2.0.3                         
[117] GenomeInfoDbData_1.2.11                
[118] ggplotify_0.1.2                        
[119] patchwork_1.2.0                        
[120] munsell_0.5.1                          
[121] Rcpp_1.0.12                            
[122] ape_5.8                                
[123] viridis_0.6.5                          
[124] stringi_1.8.4                          
[125] ggraph_2.2.1                           
[126] zlibbioc_1.48.2                        
[127] MASS_7.3-60.0.1                        
[128] AnnotationHub_3.10.1                   
[129] plyr_1.8.9                             
[130] parallel_4.3.1                         
[131] ggrepel_0.9.5                          
[132] Biostrings_2.70.3                      
[133] graphlayouts_1.1.1                     
[134] splines_4.3.1                          
[135] hms_1.1.3                              
[136] locfit_1.5-9.9                         
[137] ps_1.7.6                               
[138] igraph_2.0.3                           
[139] ggsignif_0.6.4                         
[140] reshape2_1.4.4                         
[141] futile.options_1.0.1                   
[142] BiocVersion_3.18.1                     
[143] XML_3.99-0.16.1                        
[144] evaluate_0.23                          
[145] lambda.r_1.2.4                         
[146] BiocManager_1.30.23                    
[147] tzdb_0.4.0                             
[148] tweenr_2.0.3                           
[149] httpuv_1.6.15                          
[150] polyclip_1.10-6                        
[151] ggforce_0.4.2                          
[152] xtable_1.8-4                           
[153] restfulr_0.0.15                        
[154] tidytree_0.4.6                         
[155] rstatix_0.7.2                          
[156] later_1.3.2                            
[157] viridisLite_0.4.2                      
[158] aplot_0.2.2                            
[159] memoise_2.0.1                          
[160] GenomicAlignments_1.38.2               
[161] timechange_0.3.0