Jaspar_enrichment

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Last updated: 2024-09-26

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Knit directory: ATAC_learning/

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Ignored files:
    Ignored:    .RData
    Ignored:    .Rhistory
    Ignored:    .Rproj.user/
    Ignored:    analysis/figure/
    Ignored:    data/ACresp_SNP_table.csv
    Ignored:    data/ARR_SNP_table.csv
    Ignored:    data/All_merged_peaks.tsv
    Ignored:    data/CAD_gwas_dataframe.RDS
    Ignored:    data/CTX_SNP_table.csv
    Ignored:    data/Collapsed_expressed_NG_peak_table.csv
    Ignored:    data/DEG_toplist_sep_n45.RDS
    Ignored:    data/FRiP_first_run.txt
    Ignored:    data/Final_four_data/
    Ignored:    data/Frip_1_reads.csv
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    Ignored:    data/Frip_5_reads.csv
    Ignored:    data/Frip_6_reads.csv
    Ignored:    data/GO_KEGG_analysis/
    Ignored:    data/HF_SNP_table.csv
    Ignored:    data/Ind1_75DA24h_dedup_peaks.csv
    Ignored:    data/Ind1_TSS_peaks.RDS
    Ignored:    data/Ind1_firstfragment_files.txt
    Ignored:    data/Ind1_fragment_files.txt
    Ignored:    data/Ind1_peaks_list.RDS
    Ignored:    data/Ind1_summary.txt
    Ignored:    data/Ind2_TSS_peaks.RDS
    Ignored:    data/Ind2_fragment_files.txt
    Ignored:    data/Ind2_peaks_list.RDS
    Ignored:    data/Ind2_summary.txt
    Ignored:    data/Ind3_TSS_peaks.RDS
    Ignored:    data/Ind3_fragment_files.txt
    Ignored:    data/Ind3_peaks_list.RDS
    Ignored:    data/Ind3_summary.txt
    Ignored:    data/Ind4_79B24h_dedup_peaks.csv
    Ignored:    data/Ind4_TSS_peaks.RDS
    Ignored:    data/Ind4_V24h_fraglength.txt
    Ignored:    data/Ind4_fragment_files.txt
    Ignored:    data/Ind4_fragment_filesN.txt
    Ignored:    data/Ind4_peaks_list.RDS
    Ignored:    data/Ind4_summary.txt
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    Ignored:    data/Ind5_fragment_files.txt
    Ignored:    data/Ind5_fragment_filesN.txt
    Ignored:    data/Ind5_peaks_list.RDS
    Ignored:    data/Ind5_summary.txt
    Ignored:    data/Ind6_TSS_peaks.RDS
    Ignored:    data/Ind6_fragment_files.txt
    Ignored:    data/Ind6_peaks_list.RDS
    Ignored:    data/Ind6_summary.txt
    Ignored:    data/Knowles_4.RDS
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    Ignored:    data/LiSiLTDNRe_TE_df.RDS
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    Ignored:    data/SNP_gene_cat_list.tsv
    Ignored:    data/SNP_supp_schneider.RDS
    Ignored:    data/TE_info/
    Ignored:    data/all_TSSE_scores.RDS
    Ignored:    data/all_four_filtered_counts.txt
    Ignored:    data/aln_run1_results.txt
    Ignored:    data/anno_ind1_DA24h.RDS
    Ignored:    data/anno_ind4_V24h.RDS
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    Ignored:    data/background_n45_he_peaks.RDS
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    Ignored:    data/cardiomyocyte_FRIP.csv
    Ignored:    data/col_ng_peak.csv
    Ignored:    data/cormotif_full_4_run.RDS
    Ignored:    data/cormotif_full_4_run_he.RDS
    Ignored:    data/cormotif_full_6_run.RDS
    Ignored:    data/cormotif_full_6_run_he.RDS
    Ignored:    data/cormotif_probability_45_list.csv
    Ignored:    data/cormotif_probability_45_list_he.csv
    Ignored:    data/cormotif_probability_all_6_list.csv
    Ignored:    data/cormotif_probability_all_6_list_he.csv
    Ignored:    data/embryo_heart_FRIP.csv
    Ignored:    data/enhancer_list_ENCFF126UHK.bed
    Ignored:    data/enhancerdata/
    Ignored:    data/filt_Peaks_efit2.RDS
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    Ignored:    data/first_Peaksummarycounts.csv
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    Ignored:    data/full_bedfiles/
    Ignored:    data/gene_ref.csv
    Ignored:    data/gwas_1_dataframe.RDS
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    Ignored:    data/hits_files/
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    Ignored:    data/ind1_DA24hpeaks.RDS
    Ignored:    data/ind1_TSSE.RDS
    Ignored:    data/ind2_TSSE.RDS
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    Ignored:    data/ind4_V24hpeaks.RDS
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    Ignored:    data/initial_complete_stats_run1.txt
    Ignored:    data/left_ventricle_FRIP.csv
    Ignored:    data/median_24_lfc.RDS
    Ignored:    data/median_3_lfc.RDS
    Ignored:    data/mergedPeads.gff
    Ignored:    data/mergedPeaks.gff
    Ignored:    data/motif_list_full
    Ignored:    data/motif_list_n45
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    Ignored:    data/siglist_full.RDS
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    Ignored:    data/summary_peakIDandReHeat.csv
    Ignored:    data/test.list.RDS
    Ignored:    data/testnames.txt
    Ignored:    data/toplist_6.RDS
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    Ignored:    data/toplist_full_DAR_6.RDS
    Ignored:    data/toplist_n45.RDS
    Ignored:    data/trimmed_seq_length.csv
    Ignored:    data/unclassified_full_set_peaks.RDS
    Ignored:    data/unclassified_n45_set_peaks.RDS
    Ignored:    data/xstreme/
    Ignored:    trimmed_Ind1_75DA24h_S7.nodup.splited.bam/

Untracked files:
    Untracked:  DOX_DAR_assess.Rmd
    Untracked:  EAR_2_plot.pdf
    Untracked:  ESR_1_plot.pdf
    Untracked:  Firstcorr plotATAC.pdf
    Untracked:  IND1_2_3_6_corrplot.pdf
    Untracked:  LR_3_plot.pdf
    Untracked:  NR_1_plot.pdf
    Untracked:  analysis/LFC_corr.Rmd
    Untracked:  analysis/ReHeat_analysis.Rmd
    Untracked:  analysis/TE_analysis_old.Rmd
    Untracked:  analysis/my_hc_filt_counts.csv
    Untracked:  analysis/nucleosome_explore.Rmd
    Untracked:  code/IGV_snapshot_code.R
    Untracked:  code/LongDARlist.R
    Untracked:  code/TSSE.R
    Untracked:  code/just_for_Fun.R
    Untracked:  code/toplist_assembly.R
    Untracked:  lcpm_filtered_corplot.pdf
    Untracked:  log2cpmfragcount.pdf
    Untracked:  output/cormotif_probability_45_list.csv
    Untracked:  output/cormotif_probability_all_6_list.csv
    Untracked:  splited/
    Untracked:  trimmed_Ind1_75DA24h_S7.nodup.fragment.size.distribution.pdf
    Untracked:  trimmed_Ind1_75DA3h_S1.nodup.fragment.size.distribution.pdf

Unstaged changes:
    Modified:   analysis/CorMotif_data_n45.Rmd
    Modified:   analysis/Enrichment_motif.Rmd
    Modified:   analysis/GO_KEGG_analysis.Rmd
    Modified:   analysis/Peak_calling.Rmd
    Modified:   analysis/Raodah.Rmd
    Modified:   analysis/Raodah_mycount.Rmd
    Modified:   analysis/Smaller_set_DAR.Rmd
    Modified:   analysis/TE_analysis.Rmd
    Modified:   analysis/final_four_analysis.Rmd

Note that any generated files, e.g. HTML, png, CSS, etc., are not included in this status report because it is ok for generated content to have uncommitted changes.

---

These are the previous versions of the repository in which changes were made to the R Markdown (analysis/Jaspar_motif_ff.Rmd) and HTML (docs/Jaspar_motif_ff.html) files. If you’ve configured a remote Git repository (see ?wflow_git_remote), click on the hyperlinks in the table below to view the files as they were in that past version.

File	Version	Author	Date	Message
Rmd	6cdc685	reneeisnowhere	2024-09-26	updates with 4 sets of peaks

---

library(tidyverse)
# library(ggsignif)
# library(cowplot)
# library(ggpubr)

# library(sjmisc)
library(kableExtra)
library(broom)
# library(biomaRt)
library(RColorBrewer)
# library(gprofiler2)
# library(qvalue)
library(ChIPseeker)
library("TxDb.Hsapiens.UCSC.hg38.knownGene")
library("org.Hs.eg.db")
# library(ATACseqQC)
library(rtracklayer)
library(edgeR)
library(ggfortify)
library(limma)
library(readr)
library(BiocGenerics)
library(gridExtra)
library(VennDiagram)
library(scales)
# library(ggVennDiagram)
library(Cormotif)
library(BiocParallel)
library(ggpubr)
library(devtools)
# install_github('davetang/bedr')
# library(bedr)
library(JASPAR2022)
library(TFBSTools)
library(MotifDb)
library(BSgenome.Hsapiens.UCSC.hg38)

# LR_close_xstreme <- read_delim("~/Ward Lab/Cardiotoxicity/ATAC-folder/motif enrichment/meme-ff/LR_close_xstreme/xstreme.tsv",
#     delim = "\t", escape_double = FALSE, 
#     trim_ws = TRUE)
# 
# 
# saveRDS(EAR_close_xstreme,"data/Final_four_data/xstreme/EAR_close_xstreme.RDS")
# saveRDS(EAR_open_xstreme,"data/Final_four_data/xstreme/EAR_open_xstreme.RDS")
# saveRDS(ESR_open_xstreme,"data/Final_four_data/xstreme/ESR_open_xstreme.RDS")
# saveRDS(ESR_close_xstreme,"data/Final_four_data/xstreme/ESR_close_xstreme.RDS")
# saveRDS(ESR_OC_xstreme,"data/Final_four_data/xstreme/ESR_OC_xstreme.RDS")
# saveRDS(LR_close_xstreme,"data/Final_four_data/xstreme/LR_close_xstreme.RDS")
# saveRDS(LR_open_xstreme,"data/Final_four_data/xstreme/LR_open_xstreme.RDS")



EAR_close_xstreme <-
  readRDS("data/Final_four_data/xstreme/EAR_close_xstreme.RDS")%>%
  slice_head(n = length(.$ID)-3)
EAR_open_xstreme <- 
  readRDS("data/Final_four_data/xstreme/EAR_open_xstreme.RDS")%>%
  slice_head(n = length(.$ID)-3)
ESR_open_xstreme <- 
  readRDS("data/Final_four_data/xstreme/ESR_open_xstreme.RDS")%>%
  slice_head(n = length(.$ID)-3)
ESR_close_xstreme <- 
  readRDS("data/Final_four_data/xstreme/ESR_close_xstreme.RDS")%>%
  slice_head(n = length(.$ID)-3)
ESR_OC_xstreme <- 
  readRDS("data/Final_four_data/xstreme/ESR_OC_xstreme.RDS")%>%
  slice_head(n = length(.$ID)-3)
LR_close_xstreme <-
  readRDS("data/Final_four_data/xstreme/LR_close_xstreme.RDS")%>%
  slice_head(n = length(.$ID)-3)
LR_open_xstreme <-
  readRDS("data/Final_four_data/xstreme/LR_open_xstreme.RDS")%>%
  slice_head(n = length(.$ID)-3)

sea_EAR_open <- readRDS("data/Final_four_data/xstreme/sea_EAR_open.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_EAR_close <- readRDS("data/Final_four_data/xstreme/sea_EAR_close.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_ESR_close <- readRDS("data/Final_four_data/xstreme/sea_ESR_close.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_ESR_open <- readRDS("data/Final_four_data/xstreme/sea_ESR_open.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_ESR_OC <- readRDS("data/Final_four_data/xstreme/sea_ESR_OC.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_LR_open <- readRDS("data/Final_four_data/xstreme/sea_LR_open.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_LR_close <- readRDS("data/Final_four_data/xstreme/sea_LR_close.RDS")%>%
  slice_head(n = length(.$ID)-3)



# saveRDS(sea_LR_open,"data/Final_four_data/xstreme/sea_LR_open.RDS")
peakAnnoList_ff_8motif <- readRDS("data/Final_four_data/peakAnnoList_ff_8motif.RDS")
# EAR_df <- as.data.frame(peakAnnoList_n45_motif$EAR_n45_gr)
# EAR_df_gr <-  as.GRanges(peakAnnoList_n45_motif$EAR_n45_gr)
# 
# ESR_df <- as.data.frame(peakAnnoList_n45_motif$ESR_n45_gr)
# ESR_df_gr <-  as.GRanges(peakAnnoList_n45_motif$ESR_n45_gr)
# 
# LR_df <- as.data.frame(peakAnnoList_n45_motif$LR_n45_gr)
# LR_df_gr <- as.GRanges(peakAnnoList_n45_motif$LR_n45_gr)
#  
# NR_df <- as.data.frame(peakAnnoList_n45_motif$NR_n45_gr)
# NR_df_gr <-  as.GRanges(peakAnnoList_n45_motif$NR_n45_gr)
# 
# toplistall_RNA <- readRDS("data/other_papers/toplistall_RNA.RDS") 
###Because of how I applied the DEG system in RNA-seq analysis, the lFC is opposite of the 
###counts.   I did trt-veh instead of veh-trt.  therefore I need to multiply lfc by -1 to get t
###the right correlation.

# toplistall_RNA <- toplistall_RNA %>% 
#   mutate(logFC = logFC*(-1))
# 
# RNA_expresed_genes <- toplistall_RNA %>% 
#   # dplyr::filter(adj.P.Val <0.05) %>% 
#    mutate(expression = if_else(logFC<0,"down","up")) %>% 
#   dplyr::select(ENTREZID,SYMBOL,expression) %>% 
#   # dplyr::select(ENTREZID,SYMBOL) %>% 
#   unique(.)  
# RNA_expresed_genes_DE <- toplistall_RNA %>% 
#   dplyr::filter(adj.P.Val <0.05) %>%
#   mutate(expression = if_else(logFC<0,"down","up")) %>% 
#   dplyr::select(ENTREZID,SYMBOL,expression) %>% 
#   unique(.) 

Enrichment all peaks to NR peaks

EAR_open_xstreme%>% 
  dplyr::select(SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
  arrange(.,EVALUE) %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs in EAR v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs in EAR v NR

SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
MA0028.2	ELK1	MA0028.2	9.96e-21	8.47e-18
MA0759.2	ELK3	MA0759.2	3.63e-20	3.09e-17
MA0764.3	ETV4	MA0764.3	1.39e-17	1.18e-14
MA0765.3	ETV5	MA0765.3	3e-16	2.55e-13
MA0506.2	Nrf1	MA0506.2	1.8e-15	1.53e-12
MA1713.1	ZNF610	MA1713.1	1.57e-13	1.33e-10
MA0748.2	YY2	MA0748.2	4.05e-13	3.44e-10
MA1721.1	ZNF93	MA1721.1	8.74e-12	7.44e-09
MA1583.1	ZFP57	MA1583.1	9.6e-12	8.17e-09
MA1650.1	ZBTB14	MA1650.1	3.47e-11	2.96e-08
MA0645.1	ETV6	MA0645.1	5.29e-11	4.5e-08
MA1651.1	ZFP42	MA1651.1	2.24e-10	1.91e-07
MA0641.1	ELF4	MA0641.1	5.83e-09	4.96e-06
MA1484.1	ETS2	MA1484.1	9.13e-09	7.77e-06
MA1122.1	TFDP1	MA1122.1	1.08e-08	9.17e-06
MA0763.1	ETV3	MA0763.1	3.48e-08	2.96e-05
MA1931.1	ELK1::HOXA1	MA1931.1	4.49e-08	3.82e-05
MA1708.1	ETV7	MA1708.1	7.67e-08	6.52e-05
MA0156.3	FEV	MA0156.3	1.56e-07	0.000133
MA1483.2	ELF2	MA1483.2	1.84e-07	0.000157
MA0760.1	ERF	MA0760.1	3.21e-07	0.000273
MA0475.2	FLI1	MA0475.2	3.4e-07	0.000289
MA1711.1	ZNF343	MA1711.1	4.75e-07	0.000405
MA0632.2	TCFL5	MA0632.2	5.58e-07	0.000475
MA0024.3	E2F1	MA0024.3	8.18e-07	0.000696
MA0695.1	ZBTB7C	MA0695.1	1.22e-06	0.00104
MA0146.2	Zfx	MA0146.2	1.23e-06	0.00105
MA0527.1	ZBTB33	MA0527.1	1.26e-06	0.00107
MA0472.2	EGR2	MA0472.2	1.8e-06	0.00153
MA1933.1	ELK1::SREBF2	MA1933.1	2.38e-06	0.00203
MA0615.1	Gmeb1	MA0615.1	3.63e-06	0.00309
MA0750.2	ZBTB7A	MA0750.2	7.24e-06	0.00616
MA0098.3	ETS1	MA0098.3	8.15e-06	0.00694
MA0506.2 (Nrf1)	STREME-1	1-GCCGGCGCAGCC	3.9e-12	0.00744
MA0131.2	HINFP	MA0131.2	9.26e-06	0.00788
MA1727.1	ZNF417	MA1727.1	1.52e-05	0.0129
2-CGCTTCGHY	STREME-2	2-CGCTTCGHY	8.24e-10	0.0157
MA1569.1	TFAP2E	MA1569.1	1.87e-05	0.0159
MA0865.2	E2F8	MA0865.2	2.36e-05	0.0201
3-CGRGCCGCCK	STREME-3	3-CGRGCCGCCK	1.27e-15	0.0202
MA1684.1	Foxn1	MA1684.1	2.46e-05	0.0209
MA1721.1 (ZNF93)	STREME-4	4-CGGCGGCSGCGSC	6.87e-12	0.0228
MA1099.2	HES1	MA1099.2	2.77e-05	0.0236
MA0006.1	Ahr::Arnt	MA0006.1	3.19e-05	0.0272
5-CGGCCGGCGA	STREME-5	5-CGGCCGGCGA	2.2e-17	0.0274
MA1932.1	ELK1::HOXB13	MA1932.1	3.35e-05	0.0285
MA1513.1	KLF15	MA1513.1	3.47e-05	0.0295
6-CCGGCGCC	STREME-6	6-CCGGCGCC	7.53e-17	0.0332
MA0506.2 (Nrf1)	STREME-7	7-GCGSGCSCGC	2.08e-19	0.045
MA1107.2 (KLF9)	STREME-8	8-ACCACACACACACAA	0.00786	0.0638
9-CGCCGAACTC	STREME-9	9-CGCCGAACTC	4e-18	0.0643
MA0759.2 (ELK3)	STREME-10	10-CCGGAAGTGCY	1.49e-22	0.324

EAR_close_xstreme %>% 
  dplyr::select(SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
  arrange(.,EVALUE) %>% 
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  # dplyr::filter(., EVALUE<0.05) %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs in EAR close") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs in EAR close

SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
MA0477.2	FOSL1	MA0477.2	4.1e-93	3.55e-90
MA0489.2	Jun	MA0489.2	5.02e-88	4.35e-85
MA0490.2	JUNB	MA0490.2	5.4e-87	4.68e-84
MA0099.3	FOS::JUN	MA0099.3	2.02e-85	1.75e-82
MA1130.1	FOSL2::JUN	MA1130.1	4.88e-85	4.23e-82
MA0491.2	JUND	MA0491.2	2.41e-83	2.09e-80
MA1141.1	FOS::JUND	MA1141.1	1.24e-82	1.08e-79
MA1928.1	BNC2	MA1928.1	1.69e-82	1.47e-79
MA1144.1	FOSL2::JUND	MA1144.1	2.01e-82	1.74e-79
MA1634.1	BATF	MA1634.1	3.56e-82	3.08e-79
MA0462.2	BATF::JUN	MA0462.2	3.59e-82	3.11e-79
MA0835.2	BATF3	MA0835.2	1.93e-81	1.68e-78
MA1633.2	BACH1	MA1633.2	5.68e-81	4.92e-78
MA1138.1	FOSL2::JUNB	MA1138.1	6.58e-80	5.7e-77
MA0841.1	NFE2	MA0841.1	1.94e-77	1.68e-74
MA1988.1	Atf3	MA1988.1	7.55e-77	6.54e-74
MA1134.1	FOS::JUNB	MA1134.1	6.56e-74	5.69e-71
MA0478.1	FOSL2	MA0478.1	9.68e-74	8.39e-71
MA1101.2	BACH2	MA1101.2	2.21e-73	1.92e-70
MA0476.1	FOS	MA0476.1	2.69e-72	2.33e-69
MA0655.1	JDP2	MA0655.1	6.35e-72	5.51e-69
MA1137.1	FOSL1::JUNB	MA1137.1	3.87e-71	3.36e-68
MA1128.1	FOSL1::JUN	MA1128.1	1.19e-68	1.03e-65
MA1142.1	FOSL1::JUND	MA1142.1	4.84e-67	4.2e-64
MA1135.1	FOSB::JUNB	MA1135.1	6.93e-67	6.01e-64
MA0501.1	MAF::NFE2	MA0501.1	3.17e-61	2.75e-58
MA0766.2	GATA5	MA0766.2	2.45e-60	2.13e-57
MA0089.2	MAFG::NFE2L1	MA0089.2	2.62e-59	2.27e-56
MA1132.1	JUN::JUNB	MA1132.1	3.14e-59	2.72e-56
MA0496.3	MAFK	MA0496.3	1.67e-51	1.45e-48
MA1125.1 (ZNF384)	MEME-1	WTTTTTTTTTTTTTT	4.13e-10	1.5e-48
MA0150.2	Nfe2l2	MA0150.2	5.26e-51	4.56e-48
MA0036.3	GATA2	MA0036.3	2.16e-47	1.87e-44
MA0774.1	MEIS2	MA0774.1	4.9e-47	4.24e-44
MA0018.4	CREB1	MA0018.4	9.34e-46	8.1e-43
MA0037.4	Gata3	MA0037.4	4.79e-43	4.15e-40
MA1970.1	TRPS1	MA1970.1	1.23e-40	1.07e-37
MA0782.2	PKNOX1	MA0782.2	1.29e-39	1.12e-36
MA1652.1 (ZKSCAN5)	MEME-2	KRRGRWGGVRGDGAG	3.23e-35	1.7e-34
MA1632.1	ATF2	MA1632.1	2.7e-36	2.34e-33
MA1104.2	GATA6	MA1104.2	1.32e-35	1.15e-32
MA0482.2	GATA4	MA0482.2	1.21e-34	1.05e-31
MA1114.1	PBX3	MA1114.1	5.05e-33	4.38e-30
MA0035.4	GATA1	MA0035.4	6.45e-33	5.6e-30
MA0140.2	GATA1::TAL1	MA0140.2	2.15e-32	1.87e-29
MA0775.1	MEIS3	MA0775.1	5.89e-32	5.1e-29
MA0797.1	TGIF2	MA0797.1	3.88e-31	3.37e-28
MA0842.2	NRL	MA0842.2	8.98e-30	7.79e-27
MA0612.2	EMX1	MA0612.2	1.45e-29	1.26e-26
GCTGGAGTGCAGTGG	MEME-3	GCTGGAGTGCAGTGG	2.2e-22	7.7e-26
MA0707.2	MNX1	MA0707.2	7.41e-28	6.42e-25
MA0676.1	Nr2e1	MA0676.1	9.62e-28	8.34e-25
MA1480.1	DPRX	MA1480.1	1.22e-27	1.06e-24
MA0829.2	SREBF1	MA0829.2	5.49e-27	4.76e-24
MA0681.2	PHOX2B	MA0681.2	5.89e-26	5.1e-23
MA0070.1	PBX1	MA0070.1	8.7e-26	7.55e-23
MA1519.1	LHX5	MA1519.1	1.77e-25	1.54e-22
MA1564.1	SP9	MA1564.1	3.78e-25	3.28e-22
MA1139.1	FOSL2::JUNB	MA1139.1	4.44e-25	3.85e-22
MA1495.1	HOXA1	MA1495.1	8.78e-25	7.61e-22
MA0753.2	ZNF740	MA0753.2	2.48e-24	2.15e-21
MA1145.1	FOSL2::JUND	MA1145.1	3.36e-24	2.91e-21
MA1653.1	ZNF148	MA1653.1	4.79e-24	4.16e-21
MA0498.2	MEIS1	MA0498.2	5.18e-24	4.49e-21
MA1512.1	KLF11	MA1512.1	1e-23	8.68e-21
MA0596.1	SREBF2	MA0596.1	1.08e-23	9.37e-21
MA0599.1	KLF5	MA0599.1	1.54e-23	1.33e-20
MA0659.3	Mafg	MA0659.3	1.68e-23	1.46e-20
MA0595.1	SREBF1	MA0595.1	1.8e-23	1.56e-20
MA0661.1	MEOX1	MA0661.1	2.31e-23	2.01e-20
MA0611.2	Dux	MA0611.2	3.39e-23	2.94e-20
MA0492.1	JUND	MA0492.1	4.82e-23	4.18e-20
MA0027.2	EN1	MA0027.2	7.92e-23	6.87e-20
MA0039.4	KLF4	MA0039.4	1.04e-22	8.97e-20
MA1110.2	Nr1H4	MA1110.2	1.85e-22	1.6e-19
MA0904.2	HOXB5	MA0904.2	3.21e-22	2.78e-19
MA1593.1	ZNF317	MA1593.1	5.59e-22	4.85e-19
MA0886.1	EMX2	MA0886.1	6.01e-22	5.21e-19
MA1511.2	KLF10	MA1511.2	8.57e-22	7.43e-19
RGRGTCTYRCTCTGT	MEME-6	RGRGTCTYRCTCTGT	3.52e-19	1.4e-18
MA0742.2	KLF12	MA0742.2	1.64e-21	1.42e-18
GCCTGTAATCCCAGC	MEME-4	GCCTGTAATCCCAGC	3.37e-15	1.5e-18
MA1107.2	KLF9	MA1107.2	3.04e-21	2.64e-18
MA0881.1	Dlx4	MA0881.1	4.6e-21	3.99e-18
MA0631.1	Six3	MA0631.1	5.23e-21	4.54e-18
MA0709.1	Msx3	MA0709.1	6.26e-21	5.43e-18
MA1959.1	KLF7	MA1959.1	6.31e-21	5.47e-18
MA1571.1	TGIF2LX	MA1571.1	6.63e-21	5.75e-18
MA0880.1	Dlx3	MA0880.1	8.29e-21	7.19e-18
MA0666.2	MSX1	MA0666.2	8.82e-21	7.64e-18
MA0705.1	Lhx8	MA0705.1	1.23e-20	1.07e-17
MA1143.1	FOSL1::JUND	MA1143.1	1.28e-20	1.11e-17
MA1530.1	NKX6-3	MA1530.1	2.13e-20	1.85e-17
MA1129.1	FOSL1::JUN	MA1129.1	3.06e-20	2.65e-17
MA0685.2	SP4	MA0685.2	5.01e-20	4.35e-17
MA0516.3	SP2	MA0516.3	7.14e-20	6.19e-17
MA0132.2	PDX1	MA0132.2	7.24e-20	6.28e-17
MA0882.1	DLX6	MA0882.1	8.06e-20	6.99e-17
MA0741.1	KLF16	MA0741.1	1.08e-19	9.34e-17
MA0680.2	Pax7	MA0680.2	1.11e-19	9.63e-17
MA0628.1	POU6F1	MA0628.1	1.13e-19	9.83e-17
MA0654.1	ISX	MA0654.1	1.22e-19	1.06e-16
MA0688.1	TBX2	MA0688.1	1.26e-19	1.09e-16
MA0894.1	HESX1	MA0894.1	1.7e-19	1.47e-16
MA0644.2	ESX1	MA0644.2	2.36e-19	2.05e-16
MA1522.1	MAZ	MA1522.1	2.98e-19	2.58e-16
MA0802.1	TBR1	MA0802.1	4.51e-19	3.91e-16
MA0912.2	HOXD3	MA0912.2	5.43e-19	4.71e-16
MA0117.2	Mafb	MA0117.2	1.09e-18	9.48e-16
MA0902.2	HOXB2	MA0902.2	1.23e-18	1.07e-15
MA1572.1	TGIF2LY	MA1572.1	1.52e-18	1.31e-15
MA0805.1	TBX1	MA0805.1	2.83e-18	2.45e-15
MA1578.1	VEZF1	MA1578.1	2.95e-18	2.56e-15
MA1535.1	NR2C1	MA1535.1	3.56e-18	3.09e-15
MA0889.1	GBX1	MA0889.1	3.63e-18	3.14e-15
MA0708.2	MSX2	MA0708.2	3.73e-18	3.23e-15
MA1720.1	ZNF85	MA1720.1	4.72e-18	4.09e-15
MA1618.1	Ptf1a	MA1618.1	5.6e-18	4.85e-15
MA0803.1	TBX15	MA0803.1	6.04e-18	5.24e-15
MA0690.2	TBX21	MA0690.2	6.13e-18	5.31e-15
MA0162.4	EGR1	MA0162.4	6.18e-18	5.36e-15
MA0495.3	MAFF	MA0495.3	6.98e-18	6.05e-15
MA1710.1	ZNF257	MA1710.1	7.54e-18	6.54e-15
MA0740.2	KLF14	MA0740.2	8.03e-18	6.96e-15
MA1630.2	ZNF281	MA1630.2	8.34e-18	7.23e-15
MA1996.1	Nr1H2	MA1996.1	9.66e-18	8.37e-15
MA0710.1	NOTO	MA0710.1	1.29e-17	1.12e-14
MA0691.1	TFAP4	MA0691.1	1.48e-17	1.28e-14
MA0806.1	TBX4	MA0806.1	1.54e-17	1.33e-14
MA0258.2	ESR2	MA0258.2	1.9e-17	1.65e-14
MA0704.1	Lhx4	MA0704.1	2.49e-17	2.16e-14
MA2003.1	NKX2-4	MA2003.1	3.82e-17	3.31e-14
MA0672.1	NKX2-3	MA0672.1	3.86e-17	3.34e-14
MA0528.2	ZNF263	MA0528.2	3.92e-17	3.4e-14
MA0700.2	LHX2	MA0700.2	4e-17	3.47e-14
MA0093.3	USF1	MA0093.3	4.5e-17	3.9e-14
MA0620.3	MITF	MA0620.3	8.27e-17	7.17e-14
MA0879.2	DLX1	MA0879.2	9.57e-17	8.3e-14
MA0746.2	SP3	MA0746.2	1.15e-16	9.98e-14
MA0713.1	PHOX2A	MA0713.1	1.27e-16	1.1e-13
MA0726.1	VSX2	MA0726.1	1.4e-16	1.22e-13
MA1723.1	PRDM9	MA1723.1	1.62e-16	1.41e-13
MA0483.1	Gfi1B	MA0483.1	1.69e-16	1.47e-13
MA0017.2	NR2F1	MA0017.2	1.7e-16	1.48e-13
MA1119.1	SIX2	MA1119.1	1.79e-16	1.55e-13
MA0014.3	PAX5	MA0014.3	2.36e-16	2.05e-13
MA0800.1	EOMES	MA0800.1	3.49e-16	3.02e-13
MA0910.2	HOXD8	MA0910.2	3.68e-16	3.19e-13
MA0717.1	RAX2	MA0717.1	3.78e-16	3.27e-13
MA1566.2	TBX3	MA1566.2	3.98e-16	3.45e-13
MA1146.1	NR1H4::RXRA	MA1146.1	4.31e-16	3.74e-13
MA1505.1	HOXC8	MA1505.1	4.61e-16	4e-13
MA1729.1	ZNF680	MA1729.1	5.1e-16	4.42e-13
MA1481.1	DRGX	MA1481.1	5.31e-16	4.6e-13
MA0674.1	NKX6-1	MA0674.1	6.43e-16	5.58e-13
MA1108.2	MXI1	MA1108.2	8.62e-16	7.47e-13
MA1960.1	MGA::EVX1	MA1960.1	1.01e-15	8.72e-13
MA0673.1	NKX2-8	MA0673.1	1.05e-15	9.1e-13
MA0591.1	Bach1::Mafk	MA0591.1	1.09e-15	9.45e-13
MA1644.1	NFYC	MA1644.1	1.26e-15	1.09e-12
MA0747.1	SP8	MA0747.1	1.32e-15	1.14e-12
MA1961.1	PATZ1	MA1961.1	1.62e-15	1.41e-12
MA0900.2	HOXA2	MA0900.2	1.68e-15	1.45e-12
MA1102.2	CTCFL	MA1102.2	1.82e-15	1.57e-12
TGTGTGTGTGTGTGT	MEME-5	TGTGTGTGTGTGTGT	0.614	1.7e-12
MA0719.1	RHOXF1	MA0719.1	2.01e-15	1.74e-12
MA1474.1	CREB3L4	MA1474.1	2.72e-15	2.36e-12
MA0715.1	PROP1	MA0715.1	3.27e-15	2.83e-12
MA1476.2	Dlx5	MA1476.2	3.54e-15	3.07e-12
MA1994.1	Nkx2-1	MA1994.1	3.83e-15	3.32e-12
MA0125.1	Nobox	MA0125.1	3.92e-15	3.39e-12
MA1615.1	Plagl1	MA1615.1	3.95e-15	3.42e-12
MA0908.1	HOXD11	MA0908.1	4.87e-15	4.22e-12
MA0875.1	BARX1	MA0875.1	5.1e-15	4.42e-12
MA0883.1	Dmbx1	MA0883.1	5.28e-15	4.58e-12
MA1965.1	SP5	MA1965.1	5.34e-15	4.63e-12
MA0504.1	NR2C2	MA0504.1	6.76e-15	5.86e-12
MA1133.1	JUN::JUNB	MA1133.1	7.53e-15	6.53e-12
MA0807.1	TBX5	MA0807.1	7.87e-15	6.82e-12
MA1515.1	KLF2	MA1515.1	1.05e-14	9.08e-12
MA0052.4	MEF2A	MA0052.4	1.26e-14	1.09e-11
MA0626.1	Npas2	MA0626.1	1.92e-14	1.67e-11
MA1150.1	RORB	MA1150.1	2.11e-14	1.83e-11
MA0725.1	VSX1	MA0725.1	2.14e-14	1.85e-11
MA0079.5	SP1	MA0079.5	2.2e-14	1.91e-11
MA0689.1	TBX20	MA0689.1	2.46e-14	2.13e-11
MA1126.1	FOS::JUN	MA1126.1	2.98e-14	2.58e-11
MA0071.1	RORA	MA0071.1	3.03e-14	2.63e-11
MA0768.2	Lef1	MA0768.2	3.04e-14	2.64e-11
MA0075.3	PRRX2	MA0075.3	3.51e-14	3.04e-11
MA1147.1	NR4A2::RXRA	MA1147.1	4.48e-14	3.88e-11
MA1475.1	CREB3L4	MA1475.1	4.91e-14	4.26e-11
MA0639.1	DBP	MA0639.1	5.29e-14	4.58e-11
MA0701.2	LHX9	MA0701.2	7.45e-14	6.46e-11
MA0130.1	ZNF354C	MA0130.1	8.79e-14	7.62e-11
MA0833.2	ATF4	MA0833.2	1.08e-13	9.33e-11
MA0601.1	Arid3b	MA0601.1	1.09e-13	9.48e-11
MA1514.1	KLF17	MA1514.1	1.23e-13	1.07e-10
MA0642.2	EN2	MA0642.2	1.25e-13	1.09e-10
MA0761.2	ETV1	MA0761.2	1.27e-13	1.1e-10
MA1463.1	ARGFX	MA1463.1	1.42e-13	1.23e-10
MA1587.1	ZNF135	MA1587.1	1.63e-13	1.41e-10
MA0063.2	NKX2-5	MA0063.2	1.63e-13	1.41e-10
MA1995.1	Npas4	MA1995.1	1.7e-13	1.48e-10
MA1636.1	CEBPG	MA1636.1	1.99e-13	1.73e-10
MA1643.1	NFIB	MA1643.1	2.01e-13	1.74e-10
MA1567.2	Tbx6	MA1567.2	2.04e-13	1.77e-10
MA0748.2	YY2	MA0748.2	2.17e-13	1.89e-10
MA0043.3	HLF	MA0043.3	2.24e-13	1.94e-10
MA1112.2	NR4A1	MA1112.2	2.37e-13	2.05e-10
MA0714.1	PITX3	MA0714.1	3.38e-13	2.93e-10
MA0500.2	MYOG	MA0500.2	4.01e-13	3.48e-10
MA0597.2	THAP1	MA0597.2	4.51e-13	3.91e-10
MA1652.1	ZKSCAN5	MA1652.1	5e-13	4.33e-10
MA0695.1	ZBTB7C	MA0695.1	5.28e-13	4.57e-10
MA0060.3	NFYA	MA0060.3	5.6e-13	4.86e-10
MA1136.1	FOSB::JUNB	MA1136.1	6.64e-13	5.75e-10
MA1972.1	ZFP14	MA1972.1	7.01e-13	6.08e-10
MA0733.1	EGR4	MA0733.1	7.35e-13	6.37e-10
MA0718.1	RAX	MA0718.1	7.65e-13	6.63e-10
MA0845.1	FOXB1	MA0845.1	7.77e-13	6.74e-10
MA1650.1	ZBTB14	MA1650.1	8.36e-13	7.24e-10
MA0029.1	Mecom	MA0029.1	8.94e-13	7.75e-10
MA0031.1	FOXD1	MA0031.1	9.74e-13	8.45e-10
MA0903.1	HOXB3	MA0903.1	1.33e-12	1.15e-09
MA1577.1	TLX2	MA1577.1	1.42e-12	1.23e-09
MA1547.2	PITX2	MA1547.2	1.55e-12	1.34e-09
MA0801.1	MGA	MA0801.1	1.65e-12	1.43e-09
MA1113.2	PBX2	MA1113.2	1.72e-12	1.49e-09
MA1640.1	MEIS2	MA1640.1	1.86e-12	1.61e-09
MA0098.3	ETS1	MA0098.3	1.89e-12	1.64e-09
MA0820.1	FIGLA	MA0820.1	2.43e-12	2.11e-09
MA1974.1	ZNF211	MA1974.1	2.55e-12	2.21e-09
MA0141.3	ESRRB	MA0141.3	2.56e-12	2.22e-09
MA1639.1	MEIS1	MA1639.1	2.7e-12	2.34e-09
MA0003.4	TFAP2A	MA0003.4	3e-12	2.6e-09
MA1520.1	MAF	MA1520.1	3.25e-12	2.81e-09
MA0890.1	GBX2	MA0890.1	3.62e-12	3.14e-09
MA0698.1	ZBTB18	MA0698.1	3.64e-12	3.15e-09
MA0124.2	Nkx3-1	MA0124.2	3.65e-12	3.16e-09
MA1536.1	NR2C2	MA1536.1	3.98e-12	3.45e-09
MA0899.1	HOXA10	MA0899.1	4.23e-12	3.67e-09
MA0667.1	MYF6	MA0667.1	4.32e-12	3.74e-09
MA1467.2	Atoh1	MA1467.2	4.41e-12	3.82e-09
MA0142.1	Pou5f1::Sox2	MA0142.1	4.99e-12	4.33e-09
MA0602.1	Arid5a	MA0602.1	5e-12	4.34e-09
MA0724.1	VENTX	MA0724.1	5.24e-12	4.54e-09
MA0158.2	HOXA5	MA0158.2	5.27e-12	4.57e-09
MA1500.1	HOXB6	MA1500.1	6.16e-12	5.34e-09
MA1523.1	MSANTD3	MA1523.1	6.68e-12	5.79e-09
MA0046.2	HNF1A	MA0046.2	7.07e-12	6.13e-09
MA1570.1	TFAP4	MA1570.1	7.53e-12	6.53e-09
MA0769.2	TCF7	MA0769.2	7.75e-12	6.72e-09
MA0523.1	TCF7L2	MA0523.1	9.12e-12	7.9e-09
MA0468.1	DUX4	MA0468.1	1.01e-11	8.71e-09
MA1503.1	HOXB9	MA1503.1	1.02e-11	8.87e-09
MA1621.1	Rbpjl	MA1621.1	1.09e-11	9.43e-09
MA1521.1	MAFA	MA1521.1	1.13e-11	9.78e-09
MA0658.1	LHX6	MA0658.1	1.15e-11	9.99e-09
MA0656.1	JDP2	MA0656.1	1.18e-11	1.03e-08
MA1986.1	ZNF692	MA1986.1	1.31e-11	1.14e-08
MA0095.3	Yy1	MA0095.3	1.42e-11	1.24e-08
MA0675.1	NKX6-2	MA0675.1	1.52e-11	1.32e-08
MA0621.1	mix-a	MA0621.1	1.57e-11	1.37e-08
MA1728.1	ZNF549	MA1728.1	2.42e-11	2.1e-08
MA1991.1	Hnf1A	MA1991.1	2.8e-11	2.43e-08
MA0151.1	Arid3a	MA0151.1	2.8e-11	2.43e-08
MA0830.2	TCF4	MA0830.2	2.91e-11	2.52e-08
MA1109.1	NEUROD1	MA1109.1	3.27e-11	2.83e-08
MA0684.2	RUNX3	MA0684.2	3.34e-11	2.9e-08
MA0143.4	SOX2	MA0143.4	3.89e-11	3.37e-08
MA1707.1	DMRTA1	MA1707.1	4.12e-11	3.57e-08
MA0682.2	PITX1	MA0682.2	4.36e-11	3.78e-08
MA0788.1	POU3F3	MA0788.1	4.85e-11	4.21e-08
MA1651.1	ZFP42	MA1651.1	5.08e-11	4.4e-08
MA0767.1	GCM2	MA0767.1	5.18e-11	4.49e-08
MA1527.1	NFIC	MA1527.1	5.26e-11	4.56e-08
MA0734.3	Gli2	MA0734.3	5.31e-11	4.61e-08
MA0515.1	Sox6	MA0515.1	5.39e-11	4.67e-08
MA0122.3	Nkx3-2	MA0122.3	5.55e-11	4.81e-08
MA0648.1	GSC	MA0648.1	6.15e-11	5.33e-08
MA0692.1	TFEB	MA0692.1	6.85e-11	5.94e-08
MA0669.1	NEUROG2	MA0669.1	7.16e-11	6.21e-08
MA0751.1	ZIC4	MA0751.1	8.42e-11	7.3e-08
MA0650.3	Hoxa13	MA0650.3	8.54e-11	7.4e-08
MA0793.1	POU6F2	MA0793.1	9.27e-11	8.04e-08
MA1152.1	SOX15	MA1152.1	1.01e-10	8.74e-08
MA1979.1	ZNF416	MA1979.1	1.01e-10	8.8e-08
MA1565.1	TBX18	MA1565.1	1.04e-10	9e-08
MA1990.1	Gli1	MA1990.1	1.08e-10	9.33e-08
MA0119.1	NFIC::TLX1	MA0119.1	1.09e-10	9.45e-08
MA0901.2	HOXB13	MA0901.2	1.11e-10	9.59e-08
MA0892.1	GSX1	MA0892.1	1.12e-10	9.75e-08
MA1710.1 (ZNF257)	MEME-7	CTGAGGCAGGAGRAT	3.49e-13	1e-07
MA0831.3	TFE3	MA0831.3	1.54e-10	1.33e-07
MA0102.4	CEBPA	MA0102.4	1.6e-10	1.39e-07
MA1629.1	Zic2	MA1629.1	1.64e-10	1.42e-07
MA0511.2	RUNX2	MA0511.2	1.71e-10	1.48e-07
MA1501.1	HOXB7	MA1501.1	1.73e-10	1.5e-07
MA1504.1	HOXC4	MA1504.1	1.97e-10	1.71e-07
MA0025.2	NFIL3	MA0025.2	2.06e-10	1.78e-07
MA0664.1	MLXIPL	MA0664.1	2.38e-10	2.06e-07
MA0136.3	Elf5	MA0136.3	2.46e-10	2.13e-07
MA0712.2	OTX2	MA0712.2	2.47e-10	2.14e-07
MA1502.1	HOXB8	MA1502.1	2.58e-10	2.24e-07
MA1120.1	SOX13	MA1120.1	2.69e-10	2.33e-07
MA1950.1	FLI1::FOXI1	MA1950.1	2.74e-10	2.38e-07
MA0706.1	MEOX2	MA0706.1	3.15e-10	2.73e-07
MA1468.1	ATOH7	MA1468.1	3.22e-10	2.79e-07
MA0465.2	CDX2	MA0465.2	3.27e-10	2.84e-07
MA1516.1	KLF3	MA1516.1	3.36e-10	2.91e-07
MA0905.1	HOXC10	MA0905.1	3.38e-10	2.93e-07
MA0723.2	VAX2	MA0723.2	3.5e-10	3.03e-07
MA1606.1	Foxf1	MA1606.1	3.6e-10	3.12e-07
MA0789.1	POU3F4	MA0789.1	4.43e-10	3.84e-07
MA0876.1	BSX	MA0876.1	4.68e-10	4.05e-07
MA0111.1	Spz1	MA0111.1	5.04e-10	4.37e-07
MA0846.1	FOXC2	MA0846.1	5.16e-10	4.47e-07
MA1713.1	ZNF610	MA1713.1	5.28e-10	4.58e-07
MA0032.2	FOXC1	MA0032.2	5.47e-10	4.75e-07
MA1631.1	ASCL1	MA1631.1	5.55e-10	4.82e-07
MA1645.1	NKX2-2	MA1645.1	5.58e-10	4.84e-07
MA1963.1	SATB1	MA1963.1	6.15e-10	5.33e-07
MA1528.1	NFIX	MA1528.1	6.18e-10	5.36e-07
MA0614.1	Foxj2	MA0614.1	7.14e-10	6.19e-07
MA1518.2	Lhx1	MA1518.2	7.92e-10	6.86e-07
MA0623.2	NEUROG1	MA0623.2	8.33e-10	7.22e-07
MA1131.1	FOSL2::JUN	MA1131.1	8.37e-10	7.26e-07
MA0711.1	OTX1	MA0711.1	8.99e-10	7.8e-07
MA0693.3	Vdr	MA0693.3	9.27e-10	8.04e-07
MA0630.1	SHOX	MA0630.1	9.82e-10	8.52e-07
MA0884.2	DUXA	MA0884.2	1.01e-09	8.72e-07
MA1549.1	POU6F1	MA1549.1	1.04e-09	9.04e-07
MA0897.1	Hmx2	MA0897.1	1.11e-09	9.62e-07
MA0720.1	Shox2	MA0720.1	1.17e-09	1.02e-06
MA0522.3	TCF3	MA0522.3	1.2e-09	1.04e-06
MA1517.1	KLF6	MA1517.1	1.25e-09	1.09e-06
MA0041.2	FOXD3	MA0041.2	1.27e-09	1.1e-06
MA1574.1	THRB	MA1574.1	1.33e-09	1.15e-06
MA0699.1	LBX2	MA0699.1	1.36e-09	1.18e-06
MA1656.1	ZNF449	MA1656.1	1.38e-09	1.19e-06
MA0488.1	JUN	MA0488.1	1.51e-09	1.31e-06
MA0603.1	Arntl	MA0603.1	1.56e-09	1.35e-06
MA1483.2	ELF2	MA1483.2	1.66e-09	1.44e-06
MA0497.1	MEF2C	MA0497.1	1.76e-09	1.53e-06
MA1607.1	Foxl2	MA1607.1	1.82e-09	1.58e-06
MA1628.1	Zic1::Zic2	MA1628.1	2.04e-09	1.77e-06
MA0867.2	SOX4	MA0867.2	2.08e-09	1.8e-06
MA1977.1	ZNF324	MA1977.1	2.2e-09	1.91e-06
MA0745.2	SNAI2	MA0745.2	2.38e-09	2.06e-06
MA0754.2	CUX1	MA0754.2	2.65e-09	2.3e-06
MA1111.1	NR2F2	MA1111.1	2.65e-09	2.3e-06
MA0502.2	NFYB	MA0502.2	2.8e-09	2.43e-06
MA0847.3	FOXD2	MA0847.3	2.95e-09	2.55e-06
MA1603.1	Dmrt1	MA1603.1	2.99e-09	2.59e-06
MA0885.2	Dlx2	MA0885.2	2.99e-09	2.59e-06
MA0508.3	PRDM1	MA0508.3	3.2e-09	2.77e-06
MA0808.1	TEAD3	MA0808.1	3.32e-09	2.88e-06
MA1992.1	Ikzf3	MA1992.1	3.46e-09	3e-06
MA0721.1	UNCX	MA0721.1	3.61e-09	3.13e-06
MA1498.2	HOXA7	MA1498.2	3.66e-09	3.17e-06
MA1149.1	RARA::RXRG	MA1149.1	3.73e-09	3.24e-06
MA1731.1	ZNF768	MA1731.1	3.92e-09	3.4e-06
MA0467.2	Crx	MA0467.2	4.24e-09	3.68e-06
MA1620.1	Ptf1A	MA1620.1	4.32e-09	3.75e-06
MA0092.1	Hand1::Tcf3	MA0092.1	4.46e-09	3.86e-06
MA0499.2	MYOD1	MA0499.2	5.09e-09	4.41e-06
MA0613.1	FOXG1	MA0613.1	5.2e-09	4.51e-06
MA1944.1	ETV5::DRGX	MA1944.1	5.3e-09	4.6e-06
MA0834.1	ATF7	MA0834.1	5.83e-09	5.05e-06
MA0609.2	CREM	MA0609.2	6.61e-09	5.73e-06
MA1493.1	HES6	MA1493.1	6.67e-09	5.78e-06
MA0635.1	BARHL2	MA0635.1	6.84e-09	5.93e-06
MA1100.2	ASCL1	MA1100.2	7.19e-09	6.23e-06
MA0750.2	ZBTB7A	MA0750.2	7.22e-09	6.26e-06
MA1594.1	ZNF382	MA1594.1	7.36e-09	6.38e-06
MA1127.1	FOSB::JUN	MA1127.1	7.92e-09	6.87e-06
MA0814.2	TFAP2C	MA0814.2	8.05e-09	6.98e-06
MA0146.2	Zfx	MA0146.2	8.99e-09	7.79e-06
MA0042.2	FOXI1	MA0042.2	9.38e-09	8.14e-06
MA1987.1	ZNF701	MA1987.1	9.42e-09	8.17e-06
MA0816.1	Ascl2	MA0816.1	1.06e-08	9.18e-06
MA2002.1	Zfp335	MA2002.1	1.17e-08	1.01e-05
MA0479.1	FOXH1	MA0479.1	1.25e-08	1.09e-05
MA0153.2	HNF1B	MA0153.2	1.26e-08	1.1e-05
MA0019.1	Ddit3::Cebpa	MA0019.1	1.28e-08	1.11e-05
MA0810.1	TFAP2A	MA0810.1	1.33e-08	1.15e-05
MA0716.1	PRRX1	MA0716.1	1.36e-08	1.18e-05
MA0090.3	TEAD1	MA0090.3	1.43e-08	1.24e-05
MA0514.2	Sox3	MA0514.2	1.64e-08	1.42e-05
MA0683.1	POU4F2	MA0683.1	1.67e-08	1.45e-05
MA1478.1	DMRTA2	MA1478.1	1.97e-08	1.71e-05
MA1988.1 (Atf3)	STREME-1	1-BVTGASTCABV	5.65e-86	1.97e-05
MA1122.1	TFDP1	MA1122.1	2.34e-08	2.03e-05
MA0913.2	HOXD9	MA0913.2	2.51e-08	2.18e-05
MA1151.1	RORC	MA1151.1	2.53e-08	2.19e-05
MA0668.2	Neurod2	MA0668.2	2.72e-08	2.36e-05
MA0471.2	E2F6	MA0471.2	2.76e-08	2.39e-05
MA1558.1	SNAI1	MA1558.1	3.02e-08	2.61e-05
MA0157.3	Foxo3	MA0157.3	3.25e-08	2.81e-05
MA1497.1	HOXA6	MA1497.1	3.25e-08	2.82e-05
MA0645.1	ETV6	MA0645.1	3.34e-08	2.9e-05
MA0677.1	Nr2f6	MA0677.1	3.61e-08	3.13e-05
MA1683.1	FOXA3	MA1683.1	3.72e-08	3.23e-05
MA0006.1	Ahr::Arnt	MA0006.1	4.02e-08	3.48e-05
MA0909.3	Hoxd13	MA0909.3	4.15e-08	3.6e-05
MA1581.1	ZBTB6	MA1581.1	4.36e-08	3.78e-05
MA1125.1	ZNF384	MA1125.1	4.57e-08	3.96e-05
MA0481.3	FOXP1	MA0481.3	4.64e-08	4.02e-05
MA0081.2	SPIB	MA0081.2	4.7e-08	4.08e-05
MA0145.2	Tfcp2l1	MA0145.2	4.73e-08	4.1e-05
MA0047.3	FOXA2	MA0047.3	4.81e-08	4.17e-05
MA1604.1	Ebf2	MA1604.1	4.83e-08	4.19e-05
MA0838.1	CEBPG	MA0838.1	4.95e-08	4.29e-05
MA0722.1	VAX1	MA0722.1	5.32e-08	4.61e-05
MA0600.2	RFX2	MA0600.2	5.66e-08	4.91e-05
MA0744.2	SCRT2	MA0744.2	5.72e-08	4.96e-05
MA0077.1	SOX9	MA0077.1	6.28e-08	5.44e-05
2-AGATAT	STREME-2	2-AGATAT	2e-33	5.78e-05
MA0796.1	TGIF1	MA0796.1	6.86e-08	5.95e-05
MA0080.6	Spi1	MA0080.6	7.48e-08	6.49e-05
MA1619.1	Ptf1A	MA1619.1	7.62e-08	6.61e-05
MA1487.2	FOXE1	MA1487.2	7.82e-08	6.78e-05
MA0442.2	SOX10	MA0442.2	7.9e-08	6.85e-05
MA1984.1	ZNF667	MA1984.1	7.97e-08	6.91e-05
MA0868.2	SOX8	MA0868.2	8.03e-08	6.96e-05
MA0103.3	ZEB1	MA0103.3	8.05e-08	6.98e-05
MA1951.1	FOS	MA1951.1	8.62e-08	7.47e-05
MA1648.1	TCF12	MA1648.1	8.66e-08	7.51e-05
MA1953.1	FOXO1::ELF1	MA1953.1	9.49e-08	8.23e-05
MA1946.1	ETV5::FOXI1	MA1946.1	1e-07	8.68e-05
MA0859.1	Rarg	MA0859.1	1e-07	8.68e-05
MA0914.1	ISL2	MA0914.1	1.02e-07	8.82e-05
MA0809.2	TEAD4	MA0809.2	1.02e-07	8.82e-05
MA1978.1	ZNF354A	MA1978.1	1.07e-07	9.26e-05
MA1563.2	SOX18	MA1563.2	1.17e-07	0.000101
MA1954.1	FOXO1::ELK1	MA1954.1	1.17e-07	0.000101
MA0078.2	Sox17	MA0078.2	1.18e-07	0.000102
MA1479.1	DMRTC2	MA1479.1	1.36e-07	0.000118
MA0159.1	RARA::RXRA	MA0159.1	1.54e-07	0.000133
MA0634.1	ALX3	MA0634.1	1.54e-07	0.000133
MA0850.1	FOXP3	MA0850.1	1.58e-07	0.000137
MA0649.1	HEY2	MA0649.1	1.61e-07	0.000139
MA1717.1	ZNF784	MA1717.1	1.65e-07	0.000143
MA1641.1	MYF5	MA1641.1	1.73e-07	0.00015
MA0891.1	GSC2	MA0891.1	1.78e-07	0.000155
MA0473.3	ELF1	MA0473.3	1.8e-07	0.000156
MA0598.3	EHF	MA0598.3	1.86e-07	0.000161
MA0827.1	OLIG3	MA0827.1	2.02e-07	0.000175
MA1499.1	HOXB4	MA1499.1	2.18e-07	0.000189
MA1638.1	HAND2	MA1638.1	2.4e-07	0.000209
MA0002.2	Runx1	MA0002.2	2.43e-07	0.000211
MA0826.1	OLIG1	MA0826.1	2.46e-07	0.000213
MA0783.1	PKNOX2	MA0783.1	2.59e-07	0.000225
MA0837.2	CEBPE	MA0837.2	2.62e-07	0.000228
MA0893.2	GSX2	MA0893.2	2.64e-07	0.000229
MA1532.2	NR1D2	MA1532.2	3.1e-07	0.000269
MA0464.2	BHLHE40	MA0464.2	3.16e-07	0.000274
MA0144.2	STAT3	MA0144.2	3.18e-07	0.000276
MA1148.1	PPARA::RXRA	MA1148.1	3.37e-07	0.000292
MA0646.1	GCM1	MA0646.1	3.38e-07	0.000293
MA1421.1	TCF7L1	MA1421.1	3.42e-07	0.000297
MA0480.2	Foxo1	MA0480.2	3.63e-07	0.000315
MA0874.1	Arx	MA0874.1	3.68e-07	0.000319
MA0792.1	POU5F1B	MA0792.1	3.72e-07	0.000322
MA0524.2	TFAP2C	MA0524.2	3.79e-07	0.000329
MA0828.2	SREBF2	MA0828.2	4.03e-07	0.000349
MA0851.1	Foxj3	MA0851.1	4.42e-07	0.000383
MA0033.2	FOXL1	MA0033.2	4.51e-07	0.000391
MA0811.1	TFAP2B	MA0811.1	4.74e-07	0.000411
MA0738.1	HIC2	MA0738.1	4.79e-07	0.000415
MA1105.2	GRHL2	MA1105.2	5.48e-07	0.000475
MA0461.2	Atoh1	MA0461.2	5.78e-07	0.000501
MA1507.1	HOXD4	MA1507.1	6.23e-07	0.00054
MA0498.2 (MEIS1)	STREME-3	3-STGWCAS	1.56e-52	0.000544
MA0076.2	ELK4	MA0076.2	6.42e-07	0.000557
MA0849.1	FOXO6	MA0849.1	6.46e-07	0.00056
MA1645.1 (NKX2-2)	STREME-4	4-CTACTCAG	4.28e-13	0.000563
MA0160.2	NR4A2	MA0160.2	6.82e-07	0.000591
MA1472.2	Bhlha15	MA1472.2	7.15e-07	0.00062
MA1719.1	ZNF816	MA1719.1	8.24e-07	0.000714
MA1534.1	NR1I3	MA1534.1	8.87e-07	0.000769
MA1596.1	ZNF460	MA1596.1	9.34e-07	0.00081
MA1484.1	ETS2	MA1484.1	9.81e-07	0.000851
MA1116.1	RBPJ	MA1116.1	9.84e-07	0.000853
MA1124.1	ZNF24	MA1124.1	9.96e-07	0.000864
MA0521.2	Tcf12	MA0521.2	9.99e-07	0.000866
MA0104.4	MYCN	MA0104.4	1e-06	0.00087
MA0148.4	FOXA1	MA0148.4	1.02e-06	0.000888
MA1976.1	ZNF320	MA1976.1	1.07e-06	0.000925
MA1637.1	EBF3	MA1637.1	1.45e-06	0.00125
MA0493.2	KLF1	MA0493.2	1.51e-06	0.00131
MA0259.1	ARNT::HIF1A	MA0259.1	1.55e-06	0.00134
MA0475.2	FLI1	MA0475.2	1.55e-06	0.00135
MA0755.1	CUX2	MA0755.1	1.59e-06	0.00138
MA1962.1 (POU2F1::SOX2)	STREME-5	5-CATCACA	4.15e-49	0.00139
MA1489.1	FOXN3	MA1489.1	1.9e-06	0.00165
MA0887.1	EVX1	MA0887.1	1.96e-06	0.0017
MA0766.2 (GATA5)	STREME-6	6-WGATAASRD	9.24e-59	0.00173
MA0679.2	ONECUT1	MA0679.2	2.01e-06	0.00174
MA1721.1	ZNF93	MA1721.1	2.1e-06	0.00182
MA1583.1	ZFP57	MA1583.1	2.31e-06	0.002
MA0087.2	Sox5	MA0087.2	2.67e-06	0.00232
MA0627.2	POU2F3	MA0627.2	2.92e-06	0.00253
MA0494.1	Nr1h3::Rxra	MA0494.1	2.99e-06	0.00259
MA0852.2	FOXK1	MA0852.2	3.43e-06	0.00297
MA0791.1	POU4F3	MA0791.1	3.48e-06	0.00302
MA0030.1	FOXF2	MA0030.1	3.59e-06	0.00311
MA0068.2	PAX4	MA0068.2	3.69e-06	0.0032
MA1573.2	Thap11	MA1573.2	3.95e-06	0.00343
MA1471.1	BARX2	MA1471.1	3.96e-06	0.00343
MA0640.2	ELF3	MA0640.2	4.25e-06	0.00369
MA1125.1 (ZNF384)	STREME-7	7-GTCTCWAAAAAAAA	6.53e-18	0.00383
MA1552.1	RARB	MA1552.1	4.58e-06	0.00397
MA1957.1	HOXB2::ELK1	MA1957.1	5.26e-06	0.00456
MA0038.2 (GFI1)	STREME-8	8-CTCACTGCA	1.06e-34	0.00474
MA1642.1	NEUROG2	MA1642.1	6.16e-06	0.00534
MA1624.1	Stat5a	MA1624.1	6.7e-06	0.00581
MA1588.1	ZNF136	MA1588.1	8.04e-06	0.00697
MA0911.1	Hoxa11	MA0911.1	8.12e-06	0.00704
MA0739.1	Hic1	MA0739.1	8.34e-06	0.00723
MA0804.1	TBX19	MA0804.1	8.67e-06	0.00752
MA1542.1	OSR1	MA1542.1	9.21e-06	0.00798
MA0888.1	EVX2	MA0888.1	9.29e-06	0.00805
MA1965.1 (SP5)	STREME-9	9-CCTCCCA	3.96e-31	0.00821
MA0662.1	MIXL1	MA0662.1	9.51e-06	0.00824
MA0633.2	Twist2	MA0633.2	9.67e-06	0.00838
MA1555.1	RXRB	MA1555.1	9.81e-06	0.0085
MA1625.1	Stat5b	MA1625.1	1.07e-05	0.00929
MA1985.1	ZNF669	MA1985.1	1.08e-05	0.00936
MA1496.1	HOXA4	MA1496.1	1.16e-05	0.0101
MA1103.2	FOXK2	MA1103.2	1.17e-05	0.0101
MA1635.1	BHLHE22	MA1635.1	1.44e-05	0.0125
MA0878.3	CDX1	MA0878.3	1.62e-05	0.014
MA1524.2	Msgn1	MA1524.2	1.76e-05	0.0153
MA1712.1	ZNF454	MA1712.1	1.76e-05	0.0153
MA0108.2	TBP	MA0108.2	1.89e-05	0.0164
MA0697.2	Zic3	MA0697.2	1.96e-05	0.017
MA1948.1	ETV5::HOXA2	MA1948.1	1.99e-05	0.0172
MA0896.1	Hmx1	MA0896.1	2e-05	0.0173
10-AGGCAT	STREME-10	10-AGGCAT	7.79e-32	0.0178
MA1726.1	ZNF331	MA1726.1	2.37e-05	0.0206
11-CATCTAA	STREME-11	11-CATCTAA	1.83e-38	0.0207
MA0712.2 (OTX2)	STREME-12	12-CTGTAATCCCAG	1.51e-14	0.0212
MA0817.1	BHLHE23	MA0817.1	2.52e-05	0.0219
MA1121.1	TEAD2	MA1121.1	2.57e-05	0.0223
MA0038.2	GFI1	MA0038.2	2.7e-05	0.0234
MA0072.1	RORA	MA0072.1	2.94e-05	0.0255
MA1999.1	Prdm5	MA1999.1	3.19e-05	0.0276
MA1728.1 (ZNF549)	STREME-13	13-CTGGGCAACAGA	1.14e-09	0.0286
MA0131.2	HINFP	MA0131.2	3.32e-05	0.0288
MA1983.1	ZNF582	MA1983.1	3.32e-05	0.0288
MA0137.3	STAT1	MA0137.3	3.42e-05	0.0296
MA1506.1	HOXD10	MA1506.1	3.64e-05	0.0315
MA1599.1	ZNF682	MA1599.1	3.69e-05	0.032
MA0058.3	MAX	MA0058.3	3.77e-05	0.0327
MA1608.1	Isl1	MA1608.1	3.84e-05	0.0333
MA1710.1 (ZNF257)	STREME-14	14-TCTCCTGCCTCARC	1.25e-08	0.0344
MA0466.3	CEBPB	MA0466.3	4.05e-05	0.0351
MA1993.1	Neurod2	MA1993.1	4.48e-05	0.0388
15-CTGAACA	STREME-15	15-CTGAACA	1.13e-15	0.0389
MA1997.1	Olig2	MA1997.1	4.59e-05	0.0398
MA1937.1	ERF::HOXB13	MA1937.1	4.95e-05	0.0429
MA0510.2	RFX5	MA0510.2	5.12e-05	0.0444
MA0676.1 (Nr2e1)	STREME-16	16-AACAGBCA	5.29e-41	0.045
MA0161.2	NFIC	MA0161.2	5.36e-05	0.0465
MA0832.1	Tcf21	MA0832.1	5.64e-05	0.0489
MA0592.3 (ESRRA)	STREME-17	17-AGGTCACA	2.49e-25	0.0581
MA1653.1 (ZNF148)	STREME-18	18-CMTCCCC	3.31e-20	0.0627
MA1632.1 (ATF2)	STREME-19	19-ACCTCAT	1.13e-29	0.071

ESR_open_xstreme %>% 
 dplyr::select(SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
   arrange(.,EVALUE) %>% 
   dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  # dplyr::filter(., EVALUE<0.05) %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs in ESR open") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "800px")

Enriched motifs in ESR open

SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
MA0490.2	JUNB	MA0490.2	4.45e-102	3.85e-99
MA0491.2	JUND	MA0491.2	9.18e-95	7.95e-92
MA1130.1	FOSL2::JUN	MA1130.1	3.34e-92	2.89e-89
MA1142.1	FOSL1::JUND	MA1142.1	1.32e-89	1.14e-86
MA0099.3	FOS::JUN	MA0099.3	4.73e-89	4.09e-86
MA0477.2	FOSL1	MA0477.2	2.64e-87	2.29e-84
MA1138.1	FOSL2::JUNB	MA1138.1	6.32e-87	5.47e-84
MA1141.1	FOS::JUND	MA1141.1	1.41e-85	1.22e-82
MA1137.1	FOSL1::JUNB	MA1137.1	2.54e-85	2.2e-82
MA1144.1	FOSL2::JUND	MA1144.1	3.81e-85	3.3e-82
MA1135.1	FOSB::JUNB	MA1135.1	2.38e-84	2.06e-81
MA1988.1	Atf3	MA1988.1	3.05e-84	2.64e-81
MA0655.1	JDP2	MA0655.1	1.01e-82	8.78e-80
MA1134.1	FOS::JUNB	MA1134.1	1.18e-79	1.02e-76
MA0841.1	NFE2	MA0841.1	1.84e-79	1.59e-76
MA1633.2	BACH1	MA1633.2	5.98e-79	5.18e-76
MA0476.1	FOS	MA0476.1	1.41e-77	1.22e-74
MA1634.1	BATF	MA1634.1	1.49e-76	1.29e-73
MA0835.2	BATF3	MA0835.2	1.76e-75	1.52e-72
MA0462.2	BATF::JUN	MA0462.2	1.45e-74	1.26e-71
MA0489.2	Jun	MA0489.2	2.18e-71	1.89e-68
MA1101.2	BACH2	MA1101.2	1.26e-69	1.09e-66
MA0861.1	TP73	MA0861.1	4.55e-68	3.94e-65
MA1155.1	ZSCAN4	MA1155.1	9.54e-67	8.26e-64
MA0106.3	TP53	MA0106.3	2.63e-62	2.28e-59
MA1128.1	FOSL1::JUN	MA1128.1	2.24e-53	1.94e-50
MA1132.1	JUN::JUNB	MA1132.1	1.75e-50	1.52e-47
MA1125.1 (ZNF384)	MEME-1	TWTTTTTTTHTTTTT	0.186	4.3e-44
MA0525.2	TP63	MA0525.2	4.56e-38	3.95e-35
ACACACACACACACA	MEME-2	ACACACACACACACA	7.04e-91	4.1e-30
MA1108.2	MXI1	MA1108.2	1.46e-25	1.27e-22
MA1547.2 (PITX2)	MEME-3	WGCTGGGATTACAGG	0.000211	1.5e-22
MA0626.1	Npas2	MA0626.1	2.64e-24	2.29e-21
MA0006.1	Ahr::Arnt	MA0006.1	9.17e-24	7.95e-21
MA0819.2	CLOCK	MA0819.2	3.84e-21	3.32e-18
MA0089.2	MAFG::NFE2L1	MA0089.2	5.88e-21	5.09e-18
MA0622.1	Mlxip	MA0622.1	6.84e-21	5.92e-18
MA0478.1	FOSL2	MA0478.1	1.4e-18	1.21e-15
MA0817.1	BHLHE23	MA0817.1	1.61e-17	1.4e-14
MA1928.1	BNC2	MA1928.1	9.49e-16	8.22e-13
MA0073.1	RREB1	MA0073.1	1.5e-15	1.3e-12
MA0623.2	NEUROG1	MA0623.2	2.75e-15	2.39e-12
MA0496.3	MAFK	MA0496.3	3.55e-15	3.07e-12
MA0004.1	Arnt	MA0004.1	2.66e-14	2.3e-11
MA1107.2 (KLF9)	STREME-1	1-CACACGCACAC	1.13e-103	2.47e-11
MA1718.1	ZNF8	MA1718.1	3.58e-14	3.1e-11
MA1107.2	KLF9	MA1107.2	3.18e-13	2.76e-10
MA1560.1	SOHLH2	MA1560.1	1.51e-12	1.31e-09
MA1974.1	ZNF211	MA1974.1	2.11e-12	1.83e-09
MA0823.1	HEY1	MA0823.1	2.37e-12	2.05e-09
MA0058.3	MAX	MA0058.3	2.8e-12	2.42e-09
MA0825.1	MNT	MA0825.1	2.83e-12	2.45e-09
2-ACACACATACAC	STREME-2	2-ACACACATACAC	5.97e-115	1.31e-08
3-CATGCACACACA	STREME-3	3-CATGCACACACA	2.51e-115	1.35e-08
4-CACACAYAYACACAC	STREME-4	4-CACACAYAYACACAC	1.69e-63	5.94e-08
MA0818.2	BHLHE22	MA0818.2	1.35e-10	1.17e-07
5-ACACACACCACAC	STREME-5	5-ACACACACCACAC	1.49e-87	2.07e-07
MA1973.1 (ZKSCAN3)	MEME-4	TGTTGCCCAGGCTGG	0.0041	2.2e-07
MA1990.1 (Gli1)	STREME-6	6-CACACACCACACACA	7.32e-100	1.08e-06
MA1107.2 (KLF9)	STREME-7	7-ACACACACACAC	2.27e-82	5.35e-06
MA1602.1	ZSCAN29	MA1602.1	7.62e-09	6.6e-06
MA0464.2	BHLHE40	MA0464.2	7.81e-09	6.76e-06
MA0501.1	MAF::NFE2	MA0501.1	8.08e-09	7e-06
MA0827.1	OLIG3	MA0827.1	2.83e-08	2.45e-05
MA0147.3	MYC	MA0147.3	2.92e-08	2.53e-05
MA0150.2	Nfe2l2	MA0150.2	5.04e-08	4.37e-05
MA0659.3	Mafg	MA0659.3	5.32e-08	4.61e-05
MA0491.2 (JUND)	STREME-8	8-NATGASTCATN	1.31e-84	5.98e-05
MA1107.2 (KLF9)	STREME-9	9-CACACACACATG	1.98e-100	6.43e-05
MA0259.1	ARNT::HIF1A	MA0259.1	8e-08	6.93e-05
MA1464.1	ARNT2	MA1464.1	2.1e-07	0.000182
MA0052.4	MEF2A	MA0052.4	4.84e-07	0.000419
MA0821.2	HES5	MA0821.2	7.8e-07	0.000676
MA1718.1 (ZNF8)	STREME-10	10-CAYACACCACA	4.89e-72	0.00093
11-CATACACACG	STREME-11	11-CATACACACG	1.49e-110	0.00104
MA0678.1	OLIG2	MA0678.1	1.38e-06	0.0012
MA0608.1	Creb3l2	MA0608.1	1.47e-06	0.00127
MA1155.1 (ZSCAN4)	STREME-12	12-CACACACAG	5.98e-75	0.00227
13-CACACACATA	STREME-13	13-CACACACATA	4.8e-99	0.00235
MA0507.2	POU2F2	MA0507.2	3.02e-06	0.00262
MA0789.1	POU3F4	MA0789.1	3.29e-06	0.00285
MA0009.2	TBXT	MA0009.2	3.39e-06	0.00294
MA0461.2	Atoh1	MA0461.2	4.66e-06	0.00403
MA0472.2	EGR2	MA0472.2	5.01e-06	0.00433
MA0259.1 (ARNT::HIF1A)	STREME-14	14-YABACRTGCMY	2.41e-50	0.00578
MA0616.2	HES2	MA0616.2	7.38e-06	0.00639
MA0649.1	HEY2	MA0649.1	7.68e-06	0.00665
15-CATGCCCACAC	STREME-15	15-CATGCCCACAC	6.81e-111	0.00932
MA1107.2 (KLF9)	STREME-16	16-CACACACA	1.56e-96	0.0193
MA1155.1 (ZSCAN4)	STREME-17	17-ACACAC	2.2e-46	0.0253
MA1106.1	HIF1A	MA1106.1	3.07e-05	0.0266
MA0497.1	MEF2C	MA0497.1	3.48e-05	0.0301
MA0059.1	MAX::MYC	MA0059.1	4.43e-05	0.0384
MA0801.1	MGA	MA0801.1	4.73e-05	0.041
MA0148.4	FOXA1	MA0148.4	4.77e-05	0.0413
MA0698.1	ZBTB18	MA0698.1	5e-05	0.0433
18-ACACACA	STREME-18	18-ACACACA	7.08e-53	0.0481
19-ACRTGYAC	STREME-19	19-ACRTGYAC	5.15e-56	0.0556
MA1108.2 (MXI1)	STREME-20	20-CACACATGTG	4.64e-58	0.832
MA1135.1 (FOSB::JUNB)	STREME-21	21-ATGASTCAT	9.62e-57	4.74

ESR_close_xstreme %>% 
  dplyr::select(SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
  arrange(.,EVALUE) %>%
   dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  # dplyr::filter(., EVALUE<0.05) %>% 
  kable(., caption = "Enriched motifs  ESR close") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "800px")

Enriched motifs ESR close

SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
MA1653.1	ZNF148	MA1653.1	6.2e-144	5.35e-141
MA0493.2	KLF1	MA0493.2	4.59e-141	3.96e-138
MA0685.2	SP4	MA0685.2	7.2e-138	6.2e-135
MA1959.1	KLF7	MA1959.1	2.94e-133	2.53e-130
MA1522.1	MAZ	MA1522.1	9.09e-133	7.83e-130
MA1511.2	KLF10	MA1511.2	2.36e-132	2.03e-129
MA0742.2	KLF12	MA0742.2	2.25e-131	1.94e-128
MA1630.2	ZNF281	MA1630.2	3e-130	2.59e-127
MA0741.1	KLF16	MA0741.1	1.01e-126	8.71e-124
MA0740.2	KLF14	MA0740.2	1.74e-126	1.5e-123
MA0079.5	SP1	MA0079.5	7.28e-122	6.28e-119
MA0599.1	KLF5	MA0599.1	3.49e-120	3.01e-117
MA0753.2	ZNF740	MA0753.2	3.09e-118	2.67e-115
MA1713.1	ZNF610	MA1713.1	5.98e-113	5.16e-110
MA0516.3	SP2	MA0516.3	7.47e-112	6.44e-109
MA0146.2	Zfx	MA0146.2	2.93e-109	2.52e-106
MA1107.2	KLF9	MA1107.2	3.95e-109	3.4e-106
MA1650.1	ZBTB14	MA1650.1	2.82e-108	2.43e-105
MA1564.1	SP9	MA1564.1	2.94e-106	2.54e-103
MA0746.2	SP3	MA0746.2	2.58e-105	2.23e-102
MA0774.1	MEIS2	MA0774.1	2.05e-104	1.76e-101
MA1961.1	PATZ1	MA1961.1	3.04e-104	2.62e-101
MA1548.1	PLAGL2	MA1548.1	5.47e-104	4.71e-101
MA0039.4	KLF4	MA0039.4	8.53e-104	7.35e-101
MA1578.1	VEZF1	MA1578.1	5.18e-101	4.46e-98
MA1615.1	Plagl1	MA1615.1	1.02e-99	8.76e-97
MA0597.2	THAP1	MA0597.2	2.47e-98	2.13e-95
MA0162.4	EGR1	MA0162.4	2.74e-97	2.37e-94
MA1515.1	KLF2	MA1515.1	5.49e-95	4.73e-92
MA1965.1	SP5	MA1965.1	1.03e-91	8.85e-89
MA0810.1	TFAP2A	MA0810.1	1.16e-91	9.95e-89
MA1643.1	NFIB	MA1643.1	1.37e-91	1.18e-88
MA1102.2	CTCFL	MA1102.2	1.71e-91	1.48e-88
MA1627.1	Wt1	MA1627.1	8.8e-91	7.59e-88
MA1981.1	ZNF530	MA1981.1	6.2e-89	5.34e-86
MA1514.1	KLF17	MA1514.1	7.01e-85	6.04e-82
MA1712.1	ZNF454	MA1712.1	2.77e-84	2.39e-81
MA1986.1	ZNF692	MA1986.1	1.52e-82	1.31e-79
MA0747.1	SP8	MA0747.1	3.77e-81	3.25e-78
MA1599.1	ZNF682	MA1599.1	3.49e-79	3.01e-76
MA1516.1	KLF3	MA1516.1	6.69e-79	5.76e-76
MA1719.1	ZNF816	MA1719.1	2.01e-77	1.73e-74
MA1512.1	KLF11	MA1512.1	1.99e-76	1.72e-73
MA1517.1	KLF6	MA1517.1	5.35e-75	4.61e-72
MA0738.1	HIC2	MA0738.1	2.64e-74	2.28e-71
MA1721.1	ZNF93	MA1721.1	4.13e-74	3.56e-71
MA0528.2	ZNF263	MA0528.2	2.78e-73	2.39e-70
MA1596.1	ZNF460	MA1596.1	1.17e-71	1.01e-68
MA0131.2	HINFP	MA0131.2	1.66e-71	1.43e-68
MA1527.1	NFIC	MA1527.1	7.62e-71	6.57e-68
MA1976.1	ZNF320	MA1976.1	1.14e-70	9.79e-68
MA1723.1	PRDM9	MA1723.1	2.5e-70	2.15e-67
MA1528.1	NFIX	MA1528.1	4.83e-70	4.16e-67
MA1631.1	ASCL1	MA1631.1	3.19e-68	2.75e-65
MA0811.1	TFAP2B	MA0811.1	6.6e-68	5.69e-65
MA0775.1	MEIS3	MA0775.1	1.22e-67	1.05e-64
MA0751.1	ZIC4	MA0751.1	1.75e-67	1.51e-64
MA1656.1	ZNF449	MA1656.1	1.08e-65	9.34e-63
MA1710.1	ZNF257	MA1710.1	1.14e-65	9.79e-63
MA0524.2	TFAP2C	MA0524.2	1.67e-65	1.44e-62
MA0471.2	E2F6	MA0471.2	3.59e-65	3.09e-62
MA0119.1	NFIC::TLX1	MA0119.1	3.47e-64	2.99e-61
MA0830.2	TCF4	MA0830.2	3.46e-63	2.98e-60
MA0130.1	ZNF354C	MA0130.1	6.66e-61	5.74e-58
MA1648.1	TCF12	MA1648.1	7.57e-57	6.53e-54
MA0734.3	Gli2	MA0734.3	1.23e-56	1.06e-53
MA1728.1	ZNF549	MA1728.1	1.88e-56	1.62e-53
MA1635.1	BHLHE22	MA1635.1	1.05e-55	9.03e-53
MA0646.1	GCM1	MA0646.1	5.21e-55	4.49e-52
MA0814.2	TFAP2C	MA0814.2	8.78e-55	7.57e-52
MA0506.2	Nrf1	MA0506.2	1e-54	8.66e-52
MA0048.2	NHLH1	MA0048.2	1.96e-54	1.69e-51
MA0733.1	EGR4	MA0733.1	3.69e-54	3.18e-51
MA0504.1	NR2C2	MA0504.1	7.01e-54	6.05e-51
MA0739.1	Hic1	MA0739.1	1.05e-53	9.08e-51
MA1628.1	Zic1::Zic2	MA1628.1	2.65e-53	2.28e-50
MA0003.4	TFAP2A	MA0003.4	8.58e-53	7.4e-50
MA0672.1	NKX2-3	MA0672.1	2.77e-52	2.39e-49
MA1997.1	Olig2	MA1997.1	3.98e-52	3.43e-49
MA0633.2	Twist2	MA0633.2	7.47e-52	6.44e-49
MA1535.1	NR2C1	MA1535.1	8.34e-52	7.19e-49
MA0803.1	TBX15	MA0803.1	1.04e-51	9.01e-49
MA1987.1	ZNF701	MA1987.1	5.77e-51	4.97e-48
MA0872.1	TFAP2A	MA0872.1	9.64e-51	8.31e-48
MA0697.2	Zic3	MA0697.2	6.33e-50	5.45e-47
MA1982.1	ZNF574	MA1982.1	7.44e-50	6.42e-47
MA1122.1	TFDP1	MA1122.1	1.5e-49	1.29e-46
MA1629.1	Zic2	MA1629.1	3.47e-48	2.99e-45
MA1972.1	ZFP14	MA1972.1	8.18e-48	7.05e-45
MA1979.1	ZNF416	MA1979.1	2.87e-47	2.47e-44
MA1993.1	Neurod2	MA1993.1	5.19e-47	4.48e-44
MA1730.1	ZNF708	MA1730.1	1.51e-46	1.31e-43
MA1985.1	ZNF669	MA1985.1	1.76e-46	1.52e-43
MA0104.4	MYCN	MA0104.4	1.89e-46	1.63e-43
MA0694.1	ZBTB7B	MA0694.1	2.22e-46	1.91e-43
MA0812.1	TFAP2B	MA0812.1	2.39e-46	2.06e-43
MA1973.1	ZKSCAN3	MA1973.1	4.78e-46	4.12e-43
MA0745.2	SNAI2	MA0745.2	7.74e-46	6.67e-43
MA1637.1	EBF3	MA1637.1	1.64e-45	1.42e-42
MA0145.2	Tfcp2l1	MA0145.2	1.74e-45	1.5e-42
MA0155.1	INSM1	MA0155.1	6.8e-45	5.86e-42
MA0807.1	TBX5	MA0807.1	8.6e-45	7.42e-42
MA0500.2	MYOG	MA0500.2	1.11e-44	9.6e-42
MA1604.1	Ebf2	MA1604.1	1.63e-44	1.41e-41
MA0258.2	ESR2	MA0258.2	1.64e-44	1.41e-41
MA0816.1	Ascl2	MA0816.1	1.66e-44	1.43e-41
MA0522.3	TCF3	MA0522.3	1.91e-44	1.65e-41
MA0103.3	ZEB1	MA0103.3	4.7e-44	4.05e-41
MA0767.1	GCM2	MA0767.1	1.34e-43	1.15e-40
MA1990.1	Gli1	MA1990.1	1.72e-43	1.48e-40
MA1652.1	ZKSCAN5	MA1652.1	3.07e-42	2.65e-39
MA0159.1	RARA::RXRA	MA0159.1	8.94e-42	7.71e-39
MA1641.1	MYF5	MA1641.1	1.01e-41	8.7e-39
MA0736.1	GLIS2	MA0736.1	3.45e-41	2.97e-38
MA0865.2	E2F8	MA0865.2	4.65e-41	4.01e-38
MA0154.4	EBF1	MA0154.4	1.27e-40	1.1e-37
MA1100.2	ASCL1	MA1100.2	1.36e-40	1.17e-37
MA1727.1	ZNF417	MA1727.1	3.7e-39	3.19e-36
MA1472.2	Bhlha15	MA1472.2	7.02e-39	6.05e-36
MA0671.1	NFIX	MA0671.1	1.35e-38	1.16e-35
MA1621.1	Rbpjl	MA1621.1	5.14e-38	4.43e-35
MA1567.2	Tbx6	MA1567.2	1.01e-37	8.69e-35
MA2003.1	NKX2-4	MA2003.1	2.1e-35	1.81e-32
MA1587.1	ZNF135	MA1587.1	2.54e-35	2.19e-32
MA0820.1	FIGLA	MA0820.1	2.79e-35	2.4e-32
MA0649.1	HEY2	MA0649.1	5.31e-35	4.58e-32
MA0805.1	TBX1	MA0805.1	1.19e-34	1.02e-31
MA2002.1	Zfp335	MA2002.1	1.2e-34	1.03e-31
MA0511.2	RUNX2	MA0511.2	1.26e-34	1.09e-31
MA0821.2	HES5	MA0821.2	2.15e-34	1.85e-31
MA1726.1	ZNF331	MA1726.1	2.25e-34	1.94e-31
MA0499.2	MYOD1	MA0499.2	3.37e-34	2.9e-31
MA0065.2	Pparg::Rxra	MA0065.2	9.98e-34	8.61e-31
MA0748.2	YY2	MA0748.2	1.46e-33	1.26e-30
MA0695.1	ZBTB7C	MA0695.1	1.77e-33	1.52e-30
MA1149.1	RARA::RXRG	MA1149.1	1.98e-33	1.71e-30
MA0521.2	Tcf12	MA0521.2	2.3e-33	1.99e-30
MA1731.1	ZNF768	MA1731.1	2.6e-33	2.24e-30
MA0806.1	TBX4	MA0806.1	5.18e-33	4.46e-30
MA0665.1	MSC	MA0665.1	6.34e-33	5.46e-30
MA0014.3	PAX5	MA0014.3	6.58e-33	5.67e-30
MA1581.1	ZBTB6	MA1581.1	1.08e-32	9.3e-30
MA0472.2	EGR2	MA0472.2	2.23e-32	1.92e-29
MA1620.1	Ptf1A	MA1620.1	4.74e-32	4.08e-29
MA1600.1	ZNF684	MA1600.1	6.24e-32	5.38e-29
MA1574.1	THRB	MA1574.1	1.07e-31	9.21e-29
MA0071.1	RORA	MA0071.1	3.04e-31	2.62e-28
MA0750.2	ZBTB7A	MA0750.2	3.83e-31	3.31e-28
MA1619.1	Ptf1A	MA1619.1	4.72e-31	4.07e-28
MA0039.4 (KLF4)	MEME-3	SWGGSWGGAGK	1.79e-131	6.2e-28
MA0498.2	MEIS1	MA0498.2	1.4e-30	1.21e-27
MA0161.2	NFIC	MA0161.2	2.08e-30	1.79e-27
MA1566.2	TBX3	MA1566.2	4.18e-30	3.6e-27
MA0815.1	TFAP2C	MA0815.1	7.71e-30	6.65e-27
MA0139.1	CTCF	MA0139.1	8.87e-30	7.65e-27
MA0691.1	TFAP4	MA0691.1	1.05e-29	9.09e-27
MA1565.1	TBX18	MA1565.1	1.08e-29	9.33e-27
MA1964.1	SMAD2	MA1964.1	2.07e-29	1.79e-26
MA1583.1	ZFP57	MA1583.1	2.83e-29	2.44e-26
MA1474.1	CREB3L4	MA1474.1	1.01e-28	8.75e-26
MA0006.1	Ahr::Arnt	MA0006.1	1.19e-27	1.03e-24
MA1941.1	ETV2::FIGLA	MA1941.1	1.88e-27	1.62e-24
MA1966.1	TFAP4::ETV1	MA1966.1	9.87e-27	8.51e-24
MA0783.1	PKNOX2	MA0783.1	1.05e-26	9.05e-24
MA0813.1	TFAP2B	MA0813.1	8.36e-26	7.21e-23
MA0670.1	NFIA	MA0670.1	8.95e-26	7.71e-23
MA0595.1	SREBF1	MA0595.1	1.2e-25	1.04e-22
MA1109.1	NEUROD1	MA1109.1	3.23e-25	2.78e-22
MA1945.1	ETV5::FIGLA	MA1945.1	3.66e-25	3.15e-22
MA0801.1	MGA	MA0801.1	4.2e-25	3.62e-22
MA1558.1	SNAI1	MA1558.1	4.27e-25	3.68e-22
MA0664.1	MLXIPL	MA0664.1	6.58e-25	5.67e-22
MA0797.1	TGIF2	MA0797.1	7.82e-25	6.74e-22
MA1723.1 (PRDM9)	MEME-1	RGSWGGGMWGG	2.77e-87	2.4e-21
MA0596.1	SREBF2	MA0596.1	2.88e-24	2.48e-21
MA0017.2	NR2F1	MA0017.2	4e-24	3.45e-21
MA0692.1	TFEB	MA0692.1	4.13e-23	3.56e-20
MA0796.1	TGIF1	MA0796.1	1.5e-21	1.3e-18
MA0626.1	Npas2	MA0626.1	2.31e-21	1.99e-18
MA1125.1 (ZNF384)	MEME-2	AAAAAAAAAAAAAAA	0.0161	3e-18
MA1531.1	NR1D1	MA1531.1	3.59e-21	3.09e-18
MA0668.2	Neurod2	MA0668.2	5.21e-21	4.49e-18
MA1493.1	HES6	MA1493.1	6.07e-21	5.24e-18
MA1929.1	CTCF	MA1929.1	8.88e-21	7.66e-18
MA1715.1	ZNF707	MA1715.1	1.04e-20	8.97e-18
MA1571.1	TGIF2LX	MA1571.1	2.06e-20	1.77e-17
MA0698.1	ZBTB18	MA0698.1	2.54e-20	2.19e-17
MA0502.2	NFYB	MA0502.2	5.09e-20	4.39e-17
MA1114.1	PBX3	MA1114.1	8.97e-20	7.73e-17
MA0632.2	TCFL5	MA0632.2	1.05e-19	9.07e-17
MA1655.1	ZNF341	MA1655.1	1.06e-19	9.15e-17
MA1645.1	NKX2-2	MA1645.1	5.54e-19	4.78e-16
MA0677.1	Nr2f6	MA0677.1	6.54e-19	5.63e-16
MA1108.2	MXI1	MA1108.2	8.03e-19	6.92e-16
MA1572.1	TGIF2LY	MA1572.1	1.12e-18	9.69e-16
MA1560.1	SOHLH2	MA1560.1	1.47e-18	1.27e-15
MA1653.1 (ZNF148)	STREME-1	1-CCCCWCCCM	6.38e-172	1.51e-15
MA0092.1	Hand1::Tcf3	MA0092.1	2.46e-18	2.12e-15
MA1996.1	Nr1H2	MA1996.1	2.91e-18	2.51e-15
MA0782.2	PKNOX1	MA0782.2	4.59e-18	3.96e-15
MA1569.1	TFAP2E	MA1569.1	4.95e-18	4.27e-15
MA0018.4	CREB1	MA0018.4	2.31e-17	1.99e-14
MA0645.1	ETV6	MA0645.1	2.38e-17	2.05e-14
MA0058.3	MAX	MA0058.3	7.59e-17	6.54e-14
MA0259.1	ARNT::HIF1A	MA0259.1	1.83e-16	1.58e-13
MA1570.1	TFAP4	MA1570.1	5.71e-16	4.92e-13
MA0060.3	NFYA	MA0060.3	5.81e-16	5e-13
MA0690.2	TBX21	MA0690.2	6.68e-16	5.76e-13
MA0608.1	Creb3l2	MA0608.1	8.02e-16	6.92e-13
MA1992.1	Ikzf3	MA1992.1	2.39e-15	2.06e-12
MA0667.1	MYF6	MA0667.1	2.52e-15	2.17e-12
MA0831.3	TFE3	MA0831.3	3.33e-15	2.87e-12
MA1642.1	NEUROG2	MA1642.1	3.46e-15	2.98e-12
MA1527.1 (NFIC)	STREME-2	2-GSTGNCASC	1.29e-157	4.3e-12
MA1601.2	ZNF75D	MA1601.2	7.58e-15	6.54e-12
MA0696.1	ZIC1	MA0696.1	2e-14	1.72e-11
MA0823.1	HEY1	MA0823.1	2.28e-14	1.96e-11
MA1547.2 (PITX2)	MEME-4	AAAGTGCTGGGATTA	0.289	2.1e-11
MA1153.1	Smad4	MA1153.1	2.55e-14	2.19e-11
MA0766.2	GATA5	MA0766.2	5.37e-14	4.63e-11
MA1716.1	ZNF76	MA1716.1	5.64e-14	4.86e-11
MA0147.3	MYC	MA0147.3	7.11e-14	6.13e-11
MA0673.1	NKX2-8	MA0673.1	7.25e-14	6.25e-11
MA0163.1	PLAG1	MA0163.1	1.19e-13	1.02e-10
MA0124.2	Nkx3-1	MA0124.2	1.75e-13	1.51e-10
MA0464.2	BHLHE40	MA0464.2	3.78e-13	3.26e-10
MA0688.1	TBX2	MA0688.1	4.23e-13	3.65e-10
MA1513.1 (KLF15)	STREME-3	3-CCAGCCC	6.85e-130	3.93e-10
MA0669.1	NEUROG2	MA0669.1	4.82e-13	4.15e-10
MA1559.1	SNAI3	MA1559.1	5.04e-13	4.34e-10
MA0829.2	SREBF1	MA0829.2	8.25e-13	7.11e-10
MA1533.1	NR1I2	MA1533.1	1.12e-12	9.66e-10
MA1485.1	FERD3L	MA1485.1	1.76e-12	1.51e-09
MA0056.2	MZF1	MA0056.2	2.27e-12	1.95e-09
MA0825.1	MNT	MA0825.1	2.91e-12	2.5e-09
MA1468.1	ATOH7	MA1468.1	6.91e-12	5.95e-09
MA1618.1	Ptf1a	MA1618.1	1.17e-11	1.01e-08
MA0802.1	TBR1	MA0802.1	1.47e-11	1.27e-08
MA1537.1	NR2F1	MA1537.1	1.58e-11	1.36e-08
MA1554.1	RFX7	MA1554.1	1.72e-11	1.48e-08
MA0093.3	USF1	MA0093.3	2.53e-11	2.18e-08
MA0764.3	ETV4	MA0764.3	3.16e-11	2.73e-08
MA0073.1	RREB1	MA0073.1	3.89e-11	3.35e-08
MA1542.1	OSR1	MA1542.1	4.23e-11	3.65e-08
MA0505.2	Nr5A2	MA0505.2	6.86e-11	5.92e-08
MA0488.1	JUN	MA0488.1	1.43e-10	1.23e-07
MA0689.1	TBX20	MA0689.1	3.54e-10	3.06e-07
MA1475.1	CREB3L4	MA1475.1	3.75e-10	3.24e-07
MA1523.1	MSANTD3	MA1523.1	3.88e-10	3.35e-07
MA1638.1	HAND2	MA1638.1	4.06e-10	3.5e-07
MA1467.2	Atoh1	MA1467.2	6.08e-10	5.24e-07
MA1123.2	TWIST1	MA1123.2	6.42e-10	5.54e-07
MA1979.1 (ZNF416)	STREME-4	4-CTGGGCC	4.99e-119	6.62e-07
MA1629.1 (Zic2)	STREME-5	5-CACAGCAG	8.19e-87	7.02e-07
MA1540.2	NR5A1	MA1540.2	8.29e-10	7.15e-07
MA1724.1	Rfx6	MA1724.1	1.14e-09	9.84e-07
MA1644.1	NFYC	MA1644.1	1.4e-09	1.21e-06
MA0607.2	BHLHA15	MA0607.2	1.72e-09	1.48e-06
MA1708.1	ETV7	MA1708.1	1.79e-09	1.55e-06
MA0492.1	JUND	MA0492.1	1.85e-09	1.6e-06
MA0111.1	Spz1	MA0111.1	2.25e-09	1.94e-06
MA0091.1	TAL1::TCF3	MA0091.1	3.09e-09	2.66e-06
MA0737.1	GLIS3	MA0737.1	3.29e-09	2.84e-06
MA0832.1	Tcf21	MA0832.1	3.8e-09	3.28e-06
MA0002.2	Runx1	MA0002.2	4.22e-09	3.64e-06
MA0141.3	ESRRB	MA0141.3	4.5e-09	3.88e-06
MA1593.1	ZNF317	MA1593.1	5.51e-09	4.75e-06
MA0528.2 (ZNF263)	STREME-6	6-CCTCCC	2.51e-109	5.06e-06
MA0036.3	GATA2	MA0036.3	6.15e-09	5.3e-06
MA1725.1	ZNF189	MA1725.1	7.96e-09	6.86e-06
MA0871.2	TFEC	MA0871.2	8.52e-09	7.34e-06
MA1099.2	HES1	MA1099.2	1.62e-08	1.4e-05
MA1556.1	RXRG	MA1556.1	1.97e-08	1.7e-05
MA0643.1	Esrrg	MA0643.1	1.98e-08	1.71e-05
MA1596.1 (ZNF460)	MEME-5	GGGAGGCYGAGGCAG	0.106	1.8e-05
MA0609.2	CREM	MA0609.2	2.1e-08	1.81e-05
MA1116.1	RBPJ	MA1116.1	2.21e-08	1.91e-05
MA1984.1	ZNF667	MA1984.1	2.48e-08	2.14e-05
MA1573.2	Thap11	MA1573.2	2.77e-08	2.39e-05
MA1557.1	SMAD5	MA1557.1	3.22e-08	2.77e-05
MA0623.2	NEUROG1	MA0623.2	5.37e-08	4.63e-05
MA1110.2	Nr1H4	MA1110.2	6.05e-08	5.21e-05
MA1711.1	ZNF343	MA1711.1	7.9e-08	6.81e-05
MA1111.1	NR2F2	MA1111.1	8.49e-08	7.32e-05
MA1513.1	KLF15	MA1513.1	9.13e-08	7.87e-05
MA1117.1	RELB	MA1117.1	9.8e-08	8.45e-05
MA0473.3	ELF1	MA0473.3	1.15e-07	9.94e-05
MA1529.1	NHLH2	MA1529.1	2.3e-07	0.000198
MA0062.3	GABPA	MA0062.3	2.84e-07	0.000245
MA1555.1	RXRB	MA1555.1	2.94e-07	0.000254
MA1106.1	HIF1A	MA1106.1	3.5e-07	0.000302
7-GCCWGGC	STREME-7	7-GCCWGGC	2.19e-109	0.000332
MA0818.2	BHLHE22	MA0818.2	4.55e-07	0.000392
MA0640.2	ELF3	MA0640.2	4.62e-07	0.000398
MA1967.1	TFAP4::FLI1	MA1967.1	4.63e-07	0.000399
MA1495.1	HOXA1	MA1495.1	5.4e-07	0.000465
MA1999.1	Prdm5	MA1999.1	5.41e-07	0.000466
MA0482.2	GATA4	MA0482.2	6.25e-07	0.000539
MA0904.2	HOXB5	MA0904.2	6.79e-07	0.000586
MA0732.1	EGR3	MA0732.1	1.06e-06	0.000912
MA1983.1 (ZNF582)	STREME-8	8-GCAGCC	9.53e-48	0.000988
MA1584.1	ZIC5	MA1584.1	1.35e-06	0.00116
MA1969.1	THRA	MA1969.1	1.64e-06	0.00141
MA0138.2	REST	MA0138.2	1.83e-06	0.00158
MA1717.1	ZNF784	MA1717.1	2.86e-06	0.00246
MA1998.1	Prdm14	MA1998.1	3.19e-06	0.00275
MA0782.2 (PKNOX1)	STREME-9	9-AGTGMCAGT	2.25e-30	0.00305
MA1722.1 (ZSCAN31)	STREME-10	10-CAGGGC	5.47e-95	0.00309
MA0592.3	ESRRA	MA0592.3	3.94e-06	0.0034
MA0474.3	Erg	MA0474.3	4.12e-06	0.00355
MA0063.2	NKX2-5	MA0063.2	6.6e-06	0.00569
MA1988.1 (Atf3)	MEME-6	CAGGCRTGAGCCACY	0.000708	0.0057
MA0003.4 (TFAP2A)	STREME-11	11-CCCTCAG	3.8e-70	0.00615
MA0860.1	Rarg	MA0860.1	9.4e-06	0.00811
MA0707.2	MNX1	MA0707.2	9.6e-06	0.00828
MA0616.2	HES2	MA0616.2	1.23e-05	0.0106
MA1532.2	NR1D2	MA1532.2	1.38e-05	0.0119
MA1632.1	ATF2	MA1632.1	1.4e-05	0.0121
MA0778.1	NFKB2	MA0778.1	1.46e-05	0.0126
MA0800.1	EOMES	MA0800.1	1.7e-05	0.0146
MA1654.1	ZNF16	MA1654.1	1.83e-05	0.0158
MA1944.1	ETV5::DRGX	MA1944.1	2.15e-05	0.0185
MA1102.2 (CTCFL)	STREME-12	12-AGGGGG	2.31e-85	0.029
MA0842.2	NRL	MA0842.2	4.36e-05	0.0376
MA0730.1	RARA	MA0730.1	4.39e-05	0.0379
MA0603.1	Arntl	MA0603.1	4.81e-05	0.0415
MA1964.1 (SMAD2)	STREME-13	13-CAGACAG	5.44e-67	1.32
MA1994.1 (Nkx2-1)	STREME-14	14-MCACTTGA	7.24e-16	2.55
15-CAGAGG	STREME-15	15-CAGAGG	5.52e-49	4.3

ESR_OC_xstreme %>% 
  dplyr::select(SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
  arrange(.,EVALUE) %>%
   dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  # dplyr::filter(., EVALUE<0.05) %>% 
  kable(., caption = "Enriched motifs  in ESR OC") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "800px")

Enriched motifs in ESR OC

SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
MA0462.2	BATF::JUN	MA0462.2	7.25e-193	6.23e-190
MA1988.1	Atf3	MA1988.1	1.02e-188	8.76e-186
MA1144.1	FOSL2::JUND	MA1144.1	5.1e-183	4.39e-180
MA0489.2	Jun	MA0489.2	1.23e-182	1.06e-179
MA0477.2	FOSL1	MA0477.2	3.36e-181	2.88e-178
MA1633.2	BACH1	MA1633.2	4.37e-181	3.76e-178
MA0099.3	FOS::JUN	MA0099.3	3.39e-180	2.91e-177
MA1141.1	FOS::JUND	MA1141.1	7.05e-180	6.06e-177
MA0835.2	BATF3	MA0835.2	1.29e-179	1.11e-176
MA1134.1	FOS::JUNB	MA1134.1	4.84e-179	4.16e-176
MA0476.1	FOS	MA0476.1	8.53e-179	7.33e-176
MA1138.1	FOSL2::JUNB	MA1138.1	1.59e-176	1.37e-173
MA1128.1	FOSL1::JUN	MA1128.1	1.07e-175	9.22e-173
MA1928.1	BNC2	MA1928.1	5.14e-174	4.42e-171
MA1130.1	FOSL2::JUN	MA1130.1	3.9e-173	3.35e-170
MA0478.1	FOSL2	MA0478.1	7.14e-171	6.14e-168
MA0490.2	JUNB	MA0490.2	4.43e-170	3.81e-167
MA0491.2	JUND	MA0491.2	1.93e-167	1.66e-164
MA1101.2	BACH2	MA1101.2	6.18e-166	5.31e-163
MA1135.1	FOSB::JUNB	MA1135.1	1.5e-164	1.29e-161
MA1137.1	FOSL1::JUNB	MA1137.1	2.27e-160	1.95e-157
MA1142.1	FOSL1::JUND	MA1142.1	2.5e-155	2.15e-152
MA1634.1	BATF	MA1634.1	5.11e-145	4.39e-142
MA1132.1	JUN::JUNB	MA1132.1	1e-141	8.6e-139
MA0841.1	NFE2	MA0841.1	8.01e-139	6.87e-136
MA0655.1	JDP2	MA0655.1	1.12e-122	9.65e-120
MA0089.2	MAFG::NFE2L1	MA0089.2	5.75e-97	4.94e-94
MA0496.3	MAFK	MA0496.3	1.38e-91	1.18e-88
MA0501.1	MAF::NFE2	MA0501.1	3.58e-74	3.07e-71
MA1138.1 (FOSL2::JUNB)	MEME-1	ATGASTCA	3.52e-182	8.1e-65
MA0150.2	Nfe2l2	MA0150.2	9.42e-66	8.09e-63
MA1125.1 (ZNF384)	MEME-2	TTTTTTTTTTTTTTT	1.19e-23	5.1e-61
MA0659.3	Mafg	MA0659.3	2.92e-58	2.51e-55
MA1639.1	MEIS1	MA1639.1	2.08e-49	1.79e-46
MA0679.2	ONECUT1	MA0679.2	1.43e-45	1.23e-42
MA0611.2	Dux	MA0611.2	5.67e-45	4.87e-42
MA1113.2	PBX2	MA1113.2	1.18e-41	1.02e-38
MA0680.2	Pax7	MA0680.2	1.69e-39	1.45e-36
MA0158.2	HOXA5	MA0158.2	1.42e-36	1.22e-33
MA0046.2	HNF1A	MA0046.2	1.45e-36	1.24e-33
MA0681.2	PHOX2B	MA0681.2	7.83e-36	6.73e-33
MA0910.2	HOXD8	MA0910.2	9.39e-36	8.06e-33
MA0706.1	MEOX2	MA0706.1	2.32e-35	1.99e-32
MA0846.1	FOXC2	MA0846.1	1.11e-34	9.54e-32
MA1502.1	HOXB8	MA1502.1	1.94e-34	1.67e-31
MA0902.2	HOXB2	MA0902.2	1.03e-33	8.82e-31
MA0755.1	CUX2	MA0755.1	6.57e-33	5.64e-30
MA0788.1	POU3F3	MA0788.1	1.51e-32	1.3e-29
MA0032.2	FOXC1	MA0032.2	1.58e-32	1.36e-29
MA0886.1	EMX2	MA0886.1	3.4e-32	2.92e-29
MA0041.2	FOXD3	MA0041.2	3.41e-32	2.93e-29
MA1505.1	HOXC8	MA1505.1	6.5e-32	5.59e-29
MA1640.1	MEIS2	MA1640.1	1.46e-31	1.26e-28
MA0791.1	POU4F3	MA0791.1	2.24e-31	1.93e-28
MA0845.1	FOXB1	MA0845.1	3.86e-31	3.32e-28
MA0785.1	POU2F1	MA0785.1	6.65e-31	5.71e-28
MA0495.3	MAFF	MA0495.3	1.09e-30	9.38e-28
MA1124.1	ZNF24	MA1124.1	1.18e-30	1.01e-27
MA0786.1	POU3F1	MA0786.1	2.02e-30	1.73e-27
MA1495.1	HOXA1	MA1495.1	3.16e-30	2.71e-27
MA0851.1	Foxj3	MA0851.1	6.65e-30	5.72e-27
MA0833.2	ATF4	MA0833.2	9.82e-30	8.43e-27
MA0757.1	ONECUT3	MA0757.1	9.96e-30	8.56e-27
MA0715.1	PROP1	MA0715.1	1.11e-29	9.52e-27
MA0766.2	GATA5	MA0766.2	2.5e-29	2.15e-26
MA1636.1	CEBPG	MA1636.1	3.48e-29	2.99e-26
MA0713.1	PHOX2A	MA0713.1	3.5e-29	3e-26
MA0675.1	NKX6-2	MA0675.1	3.87e-29	3.33e-26
MA0612.2	EMX1	MA0612.2	4.47e-29	3.84e-26
MA0707.2	MNX1	MA0707.2	1.12e-28	9.58e-26
MA0613.1	FOXG1	MA0613.1	1.54e-28	1.32e-25
MA0787.1	POU3F2	MA0787.1	2.11e-28	1.82e-25
MA0661.1	MEOX1	MA0661.1	3.47e-28	2.98e-25
MA0628.1	POU6F1	MA0628.1	5.59e-28	4.8e-25
MA1134.1 (FOS::JUNB)	STREME-1	1-DATGASTCATH	9.03999999999999e-197	7.09e-25
MA0722.1	VAX1	MA0722.1	1.31e-27	1.13e-24
MA1143.1	FOSL1::JUND	MA1143.1	1.98e-27	1.7e-24
MA1978.1	ZNF354A	MA1978.1	2.14e-27	1.84e-24
MA0682.2 (PITX1)	MEME-3	GCCTGTAATCCCAGC	3.15e-22	2e-24
MA1519.1	LHX5	MA1519.1	2.43e-27	2.09e-24
MA0912.2	HOXD3	MA0912.2	3.76e-27	3.23e-24
MA0602.1	Arid5a	MA0602.1	8.52e-27	7.32e-24
MA1480.1	DPRX	MA1480.1	9.24e-27	7.94e-24
MA0676.1	Nr2e1	MA0676.1	9.64e-27	8.28e-24
MA0674.1	NKX6-1	MA0674.1	1.26e-26	1.09e-23
MA0148.4	FOXA1	MA0148.4	1.38e-26	1.18e-23
MA0132.2	PDX1	MA0132.2	1.54e-26	1.32e-23
MA1963.1	SATB1	MA1963.1	1.64e-26	1.41e-23
MA0888.1	EVX2	MA0888.1	2.75e-26	2.36e-23
MA0142.1	Pou5f1::Sox2	MA0142.1	3.59e-26	3.08e-23
MA0792.1	POU5F1B	MA0792.1	3.74e-26	3.21e-23
MA1481.1	DRGX	MA1481.1	7.83e-26	6.72e-23
MA0630.1	SHOX	MA0630.1	1.51e-25	1.3e-22
MA0683.1	POU4F2	MA0683.1	2.4e-25	2.06e-22
MA1487.2	FOXE1	MA1487.2	2.63e-25	2.26e-22
MA0701.2	LHX9	MA0701.2	2.63e-25	2.26e-22
MA0153.2	HNF1B	MA0153.2	2.81e-25	2.41e-22
MA0724.1	VENTX	MA0724.1	2.99e-25	2.57e-22
MA0650.3	Hoxa13	MA0650.3	3.19e-25	2.74e-22
MA1115.1	POU5F1	MA1115.1	3.32e-25	2.86e-22
MA1962.1	POU2F1::SOX2	MA1962.1	4.21e-25	3.61e-22
MA0789.1	POU3F4	MA0789.1	4.4e-25	3.78e-22
MA0025.2	NFIL3	MA0025.2	5.77e-25	4.95e-22
MA0908.1	HOXD11	MA0908.1	7.82e-25	6.71e-22
MA0847.3	FOXD2	MA0847.3	1e-24	8.61e-22
MA0078.2	Sox17	MA0078.2	1.07e-24	9.19e-22
MA0035.4	GATA1	MA0035.4	1.39e-24	1.2e-21
MA0601.1	Arid3b	MA0601.1	1.51e-24	1.29e-21
MA0700.2	LHX2	MA0700.2	1.77e-24	1.52e-21
MA0075.3	PRRX2	MA0075.3	3.23e-24	2.77e-21
MA0790.1	POU4F1	MA0790.1	3.37e-24	2.89e-21
MA0043.3	HLF	MA0043.3	4.11e-24	3.53e-21
MA0037.4	Gata3	MA0037.4	4.68e-24	4.02e-21
MA0627.2	POU2F3	MA0627.2	5.29e-24	4.54e-21
MA1497.1	HOXA6	MA1497.1	7.64e-24	6.56e-21
MA0754.2	CUX1	MA0754.2	9.06e-24	7.78e-21
MA0903.1	HOXB3	MA0903.1	1.35e-23	1.16e-20
MA1577.1	TLX2	MA1577.1	1.69e-23	1.45e-20
MA0614.1	Foxj2	MA0614.1	1.7e-23	1.46e-20
MA0084.1	SRY	MA0084.1	2.3e-23	1.98e-20
MA0644.2	ESX1	MA0644.2	2.62e-23	2.25e-20
MA0900.2	HOXA2	MA0900.2	3.69e-23	3.17e-20
MA0031.1	FOXD1	MA0031.1	4.05e-23	3.48e-20
MA0718.1	RAX	MA0718.1	7.96e-23	6.84e-20
MA0887.1	EVX1	MA0887.1	8.53e-23	7.33e-20
MA1471.1	BARX2	MA1471.1	1.08e-22	9.29e-20
MA0102.4	CEBPA	MA0102.4	1.47e-22	1.26e-19
MA0904.2	HOXB5	MA0904.2	1.53e-22	1.31e-19
MA0793.1	POU6F2	MA0793.1	1.63e-22	1.4e-19
MA1104.2	GATA6	MA1104.2	1.71e-22	1.47e-19
MA0654.1	ISX	MA0654.1	1.85e-22	1.59e-19
MA0854.1	Alx1	MA0854.1	2.06e-22	1.77e-19
MA1606.1	Foxf1	MA1606.1	2.59e-22	2.22e-19
MA1125.1	ZNF384	MA1125.1	2.67e-22	2.3e-19
MA0052.4	MEF2A	MA0052.4	2.83e-22	2.43e-19
MA0658.1	LHX6	MA0658.1	3.37e-22	2.89e-19
MA0890.1	GBX2	MA0890.1	3.61e-22	3.1e-19
MA0726.1	VSX2	MA0726.1	4.78e-22	4.11e-19
MA0704.1	Lhx4	MA0704.1	5.24e-22	4.5e-19
MA0682.2	PITX1	MA0682.2	5.99e-22	5.14e-19
MA0648.1	GSC	MA0648.1	6.19e-22	5.32e-19
MA0135.1	Lhx3	MA0135.1	1.02e-21	8.72e-19
MA0723.2	VAX2	MA0723.2	1.09e-21	9.4e-19
MA0716.1	PRRX1	MA0716.1	1.65e-21	1.42e-18
ACTGCACTCCAGCCT	MEME-4	ACTGCACTCCAGCCT	7.09e-21	1.5e-18
MA1683.1	FOXA3	MA1683.1	2.55e-21	2.19e-18
MA0465.2	CDX2	MA0465.2	2.59e-21	2.22e-18
MA0909.3	Hoxd13	MA0909.3	2.63e-21	2.26e-18
MA1530.1	NKX6-3	MA1530.1	2.87e-21	2.46e-18
MA0906.1	HOXC12	MA0906.1	3.55e-21	3.05e-18
MA1463.1	ARGFX	MA1463.1	3.65e-21	3.14e-18
MA0874.1	Arx	MA0874.1	3.81e-21	3.27e-18
MA0710.1	NOTO	MA0710.1	4.33e-21	3.72e-18
MA0875.1	BARX1	MA0875.1	4.8e-21	4.12e-18
MA0523.1	TCF7L2	MA0523.1	4.85e-21	4.17e-18
MA1476.2	Dlx5	MA1476.2	5.13e-21	4.41e-18
MA0040.1	Foxq1	MA0040.1	6.17e-21	5.3e-18
MA0880.1	Dlx3	MA0880.1	6.26e-21	5.37e-18
MA0068.2	PAX4	MA0068.2	6.64e-21	5.7e-18
MA0894.1	HESX1	MA0894.1	7.22e-21	6.2e-18
MA0885.2	Dlx2	MA0885.2	8.7e-21	7.47e-18
MA0666.2	MSX1	MA0666.2	8.94e-21	7.68e-18
MA0047.3	FOXA2	MA0047.3	9.26e-21	7.96e-18
MA0882.1	DLX6	MA0882.1	1.08e-20	9.27e-18
MA0699.1	LBX2	MA0699.1	1.34e-20	1.15e-17
MA0725.1	VSX1	MA0725.1	1.66e-20	1.43e-17
MA0709.1	Msx3	MA0709.1	1.94e-20	1.66e-17
MA0717.1	RAX2	MA0717.1	3.79e-20	3.26e-17
MA0712.2	OTX2	MA0712.2	7.12e-20	6.11e-17
MA0836.2	CEBPD	MA0836.2	7.65e-20	6.58e-17
MA0867.2	SOX4	MA0867.2	8.39e-20	7.21e-17
MA0780.1	PAX3	MA0780.1	9.82e-20	8.44e-17
MA0853.1	Alx4	MA0853.1	1.04e-19	8.89e-17
MA0898.1	Hmx3	MA0898.1	1.17e-19	1.01e-16
MA1489.1	FOXN3	MA1489.1	1.2e-19	1.03e-16
MA1991.1	Hnf1A	MA1991.1	1.48e-19	1.27e-16
MA0036.3	GATA2	MA0036.3	1.58e-19	1.35e-16
MA1607.1	Foxl2	MA1607.1	1.62e-19	1.39e-16
MA0884.2	DUXA	MA0884.2	1.69e-19	1.45e-16
MA0881.1	Dlx4	MA0881.1	2.33e-19	2.01e-16
MA0720.1	Shox2	MA0720.1	2.34e-19	2.01e-16
MA0027.2	EN1	MA0027.2	2.87e-19	2.46e-16
MA0892.1	GSX1	MA0892.1	3.9e-19	3.35e-16
MA0913.2	HOXD9	MA0913.2	4.31e-19	3.7e-16
MA1139.1	FOSL2::JUNB	MA1139.1	5.57e-19	4.79e-16
MA1103.2	FOXK2	MA1103.2	5.69e-19	4.88e-16
MA1632.1	ATF2	MA1632.1	5.8e-19	4.98e-16
MA0829.2	SREBF1	MA0829.2	6.15e-19	5.28e-16
MA1729.1	ZNF680	MA1729.1	7.3e-19	6.27e-16
MA0705.1	Lhx8	MA0705.1	8.4e-19	7.22e-16
MA0889.1	GBX1	MA0889.1	9.59e-19	8.23e-16
MA1974.1	ZNF211	MA1974.1	1.01e-18	8.64e-16
MA1131.1	FOSL2::JUN	MA1131.1	1.26e-18	1.08e-15
MA0702.2	LMX1A	MA0702.2	1.36e-18	1.17e-15
MA0621.1	mix-a	MA0621.1	1.54e-18	1.33e-15
MA1518.2	Lhx1	MA1518.2	2.01e-18	1.72e-15
MA0721.1	UNCX	MA0721.1	2.3e-18	1.98e-15
MA0635.1	BARHL2	MA0635.1	2.33e-18	2e-15
MA0849.1	FOXO6	MA0849.1	2.92e-18	2.51e-15
MA1421.1	TCF7L1	MA1421.1	3.31e-18	2.85e-15
MA0018.4	CREB1	MA0018.4	3.35e-18	2.88e-15
MA0639.1	DBP	MA0639.1	4.93e-18	4.23e-15
MA0896.1	Hmx1	MA0896.1	5.79e-18	4.98e-15
MA0662.1	MIXL1	MA0662.1	6.51e-18	5.59e-15
MA1496.1	HOXA4	MA1496.1	7.15e-18	6.14e-15
MA0030.1	FOXF2	MA0030.1	7.22e-18	6.2e-15
MA0497.1	MEF2C	MA0497.1	9.77e-18	8.39e-15
MA0879.2	DLX1	MA0879.2	9.98e-18	8.58e-15
MA1970.1	TRPS1	MA1970.1	1.14e-17	9.77e-15
MA0895.1	HMBOX1	MA0895.1	1.19e-17	1.02e-14
MA0070.1	PBX1	MA0070.1	1.2e-17	1.03e-14
MA0768.2	Lef1	MA0768.2	1.21e-17	1.04e-14
MA0077.1	SOX9	MA0077.1	1.3e-17	1.11e-14
MA1960.1	MGA::EVX1	MA1960.1	1.59e-17	1.37e-14
MA0482.2	GATA4	MA0482.2	1.6e-17	1.37e-14
MA1603.1	Dmrt1	MA1603.1	1.65e-17	1.42e-14
MA1500.1	HOXB6	MA1500.1	1.74e-17	1.5e-14
MA1152.1	SOX15	MA1152.1	1.84e-17	1.58e-14
MA1145.1	FOSL2::JUND	MA1145.1	2.72e-17	2.33e-14
MA1126.1	FOS::JUN	MA1126.1	3.05e-17	2.62e-14
MA0911.1	Hoxa11	MA0911.1	3.42e-17	2.94e-14
MA0634.1	ALX3	MA0634.1	3.44e-17	2.96e-14
MA1499.1	HOXB4	MA1499.1	3.85e-17	3.3e-14
MA0852.2	FOXK1	MA0852.2	3.91e-17	3.36e-14
MA0143.4	SOX2	MA0143.4	4.56e-17	3.91e-14
MA1549.1	POU6F1	MA1549.1	6.52e-17	5.6e-14
MA0901.2	HOXB13	MA0901.2	1.02e-16	8.73e-14
MA0848.1	FOXO4	MA0848.1	1.12e-16	9.61e-14
MA0117.2	Mafb	MA0117.2	1.21e-16	1.04e-13
MA0784.2	POU1F1	MA0784.2	1.26e-16	1.08e-13
MA0483.1	Gfi1B	MA0483.1	1.3e-16	1.12e-13
MA0481.3	FOXP1	MA0481.3	1.33e-16	1.15e-13
MA0042.2	FOXI1	MA0042.2	1.7e-16	1.46e-13
MA0708.2	MSX2	MA0708.2	1.74e-16	1.5e-13
MA0593.1	FOXP2	MA0593.1	1.76e-16	1.51e-13
MA0891.1	GSC2	MA0891.1	1.9e-16	1.63e-13
MA0642.2	EN2	MA0642.2	2.29e-16	1.96e-13
MA1720.1	ZNF85	MA1720.1	2.31e-16	1.98e-13
MA0842.2	NRL	MA0842.2	2.68e-16	2.3e-13
MA1501.1	HOXB7	MA1501.1	2.96e-16	2.54e-13
MA0782.2	PKNOX1	MA0782.2	3.12e-16	2.68e-13
MA0876.1	BSX	MA0876.1	3.28e-16	2.82e-13
MA0618.1	LBX1	MA0618.1	6.67e-16	5.73e-13
MA0897.1	Hmx2	MA0897.1	1.04e-15	8.91e-13
MA0899.1	HOXA10	MA0899.1	1.13e-15	9.68e-13
MA1507.1	HOXD4	MA1507.1	1.2e-15	1.04e-12
MA1608.1	Isl1	MA1608.1	1.39e-15	1.2e-12
MA1588.1	ZNF136	MA1588.1	1.41e-15	1.21e-12
MA0905.1	HOXC10	MA0905.1	1.51e-15	1.29e-12
MA1127.1	FOSB::JUN	MA1127.1	1.58e-15	1.36e-12
MA0838.1	CEBPG	MA0838.1	2.16e-15	1.85e-12
MA0689.1	TBX20	MA0689.1	2.38e-15	2.04e-12
MA0591.1	Bach1::Mafk	MA0591.1	2.52e-15	2.17e-12
MA0492.1	JUND	MA0492.1	6.19e-15	5.32e-12
MA1657.1	ZNF652	MA1657.1	1.01e-14	8.67e-12
MA1707.1	DMRTA1	MA1707.1	1.1e-14	9.44e-12
MA0711.1	OTX1	MA0711.1	1.39e-14	1.2e-11
MA1498.2	HOXA7	MA1498.2	1.44e-14	1.23e-11
MA1111.1	NR2F2	MA1111.1	1.74e-14	1.49e-11
MA0850.1	FOXP3	MA0850.1	1.76e-14	1.51e-11
MA0620.3	MITF	MA0620.3	1.92e-14	1.65e-11
MA0514.2	Sox3	MA0514.2	2.39e-14	2.05e-11
MA0033.2	FOXL1	MA0033.2	3.98e-14	3.42e-11
MA0442.2	SOX10	MA0442.2	6.92e-14	5.95e-11
MA0461.2	Atoh1	MA0461.2	7.42e-14	6.37e-11
MA0038.2	GFI1	MA0038.2	7.98e-14	6.86e-11
MA0108.2	TBP	MA0108.2	9.02e-14	7.75e-11
MA1114.1	PBX3	MA1114.1	1.49e-13	1.28e-10
MA1645.1	NKX2-2	MA1645.1	1.8e-13	1.55e-10
MA0479.1	FOXH1	MA0479.1	1.89e-13	1.63e-10
MA0093.3	USF1	MA0093.3	2.07e-13	1.78e-10
MA0029.1	Mecom	MA0029.1	2.1e-13	1.8e-10
MA0488.1	JUN	MA0488.1	2.54e-13	2.18e-10
MA0157.3	Foxo3	MA0157.3	4.85e-13	4.17e-10
MA1504.1	HOXC4	MA1504.1	5.64e-13	4.84e-10
MA0873.1	HOXD12	MA0873.1	8.97e-13	7.71e-10
MA1133.1	JUN::JUNB	MA1133.1	1.11e-12	9.5e-10
MA1129.1	FOSL1::JUN	MA1129.1	1.19e-12	1.02e-09
MA1120.1	SOX13	MA1120.1	1.27e-12	1.09e-09
MA0714.1	PITX3	MA0714.1	2.54e-12	2.18e-09
MA0480.2	Foxo1	MA0480.2	2.63e-12	2.26e-09
MA0878.3	CDX1	MA0878.3	2.65e-12	2.27e-09
MA0893.2	GSX2	MA0893.2	2.74e-12	2.36e-09
MA1479.1	DMRTC2	MA1479.1	4.1e-12	3.52e-09
MA0087.2	Sox5	MA0087.2	4.18e-12	3.59e-09
MA0515.1	Sox6	MA0515.1	4.32e-12	3.71e-09
MA0907.1	HOXC13	MA0907.1	4.84e-12	4.16e-09
MA1975.1	ZNF214	MA1975.1	6.59e-12	5.66e-09
MA0144.2	STAT3	MA0144.2	6.72e-12	5.77e-09
MA0467.2	Crx	MA0467.2	7.67e-12	6.58e-09
MA0808.1	TEAD3	MA0808.1	7.8e-12	6.7e-09
MA1644.1	NFYC	MA1644.1	1e-11	8.62e-09
MA1562.1	SOX14	MA1562.1	1.29e-11	1.11e-08
MA2001.1	Six4	MA2001.1	1.39e-11	1.2e-08
MA0517.1	STAT1::STAT2	MA0517.1	1.62e-11	1.39e-08
MA1593.1	ZNF317	MA1593.1	1.84e-11	1.58e-08
MA0152.2	Nfatc2	MA0152.2	2.21e-11	1.9e-08
MA0596.1	SREBF2	MA0596.1	2.68e-11	2.3e-08
MA0883.1	Dmbx1	MA0883.1	3.43e-11	2.95e-08
MA1478.1	DMRTA2	MA1478.1	3.91e-11	3.36e-08
MA1996.1	Nr1H2	MA1996.1	3.97e-11	3.41e-08
MA0498.2	MEIS1	MA0498.2	4.75e-11	4.08e-08
MA0914.1	ISL2	MA0914.1	6.05e-11	5.19e-08
MA0151.1	Arid3a	MA0151.1	8.28e-11	7.11e-08
MA1709.1	ZIM3	MA1709.1	9.99e-11	8.58e-08
MA0684.2	RUNX3	MA0684.2	1.4e-10	1.2e-07
MA0629.1	Rhox11	MA0629.1	2.23e-10	1.91e-07
MA1596.1 (ZNF460)	MEME-5	RCCTCRGCCTCCCA	2.48e-12	2.1e-07
MA0095.3	Yy1	MA0095.3	2.63e-10	2.26e-07
MA0804.1	TBX19	MA0804.1	2.88e-10	2.47e-07
MA0703.2	LMX1B	MA0703.2	3.11e-10	2.67e-07
MA0800.1	EOMES	MA0800.1	3.43e-10	2.95e-07
MA1995.1	Npas4	MA1995.1	3.56e-10	3.06e-07
MA0125.1	Nobox	MA0125.1	3.76e-10	3.23e-07
MA1136.1	FOSB::JUNB	MA1136.1	4.02e-10	3.45e-07
MA0594.2	HOXA9	MA0594.2	5.19e-10	4.46e-07
MA0595.1	SREBF1	MA0595.1	5.58e-10	4.79e-07
MA1148.1	PPARA::RXRA	MA1148.1	6.16e-10	5.3e-07
MA1503.1	HOXB9	MA1503.1	6.52e-10	5.6e-07
MA0050.3	Irf1	MA0050.3	6.68e-10	5.74e-07
MA1714.1	ZNF675	MA1714.1	7.59e-10	6.52e-07
MA1534.1	NR1I3	MA1534.1	1.05e-09	8.98e-07
MA1118.1	SIX1	MA1118.1	1.07e-09	9.17e-07
MA0494.1	Nr1h3::Rxra	MA0494.1	1.08e-09	9.27e-07
MA1119.1	SIX2	MA1119.1	1.14e-09	9.78e-07
MA0869.2	Sox11	MA0869.2	1.46e-09	1.25e-06
MA1105.2	GRHL2	MA1105.2	1.96e-09	1.68e-06
MA1520.1	MAF	MA1520.1	2.29e-09	1.97e-06
MA0769.2	TCF7	MA0769.2	2.55e-09	2.19e-06
MA1110.2	Nr1H4	MA1110.2	2.87e-09	2.46e-06
MA1570.1	TFAP4	MA1570.1	2.9e-09	2.49e-06
MA1523.1	MSANTD3	MA1523.1	6.12e-09	5.25e-06
MA1540.2	NR5A1	MA1540.2	7.72e-09	6.63e-06
MA0063.2	NKX2-5	MA0063.2	9.87e-09	8.48e-06
MA1112.2	NR4A1	MA1112.2	1.66e-08	1.43e-05
MA0831.3	TFE3	MA0831.3	2.45e-08	2.11e-05
MA0756.2	ONECUT2	MA0756.2	2.64e-08	2.26e-05
MA0688.1	TBX2	MA0688.1	3.73e-08	3.21e-05
MA0606.2	Nfat5	MA0606.2	4.61e-08	3.96e-05
MA1506.1	HOXD10	MA1506.1	4.64e-08	3.99e-05
MA1718.1	ZNF8	MA1718.1	4.84e-08	4.16e-05
MA1977.1	ZNF324	MA1977.1	4.97e-08	4.27e-05
MA0802.1	TBR1	MA0802.1	5.19e-08	4.45e-05
MA0140.2	GATA1::TAL1	MA0140.2	6.47e-08	5.56e-05
MA0258.2	ESR2	MA0258.2	6.74e-08	5.79e-05
MA1536.1	NR2C2	MA1536.1	6.9e-08	5.92e-05
MA0677.1	Nr2f6	MA0677.1	8.02e-08	6.89e-05
MA1420.1	IRF5	MA1420.1	8.06e-08	6.92e-05
MA0840.1	Creb5	MA0840.1	8.3e-08	7.13e-05
MA1984.1	ZNF667	MA1984.1	1.03e-07	8.88e-05
MA0485.2	HOXC9	MA0485.2	1.09e-07	9.33e-05
MA0744.2	SCRT2	MA0744.2	1.12e-07	9.6e-05
MA0060.3	NFYA	MA0060.3	1.13e-07	9.68e-05
MA1968.1	TFCP2	MA1968.1	1.2e-07	0.000103
MA1473.1	CDX4	MA1473.1	1.22e-07	0.000105
MA0673.1	NKX2-8	MA0673.1	1.69e-07	0.000145
MA0124.2	Nkx3-1	MA0124.2	2.01e-07	0.000173
MA0141.3	ESRRB	MA0141.3	2.2e-07	0.000189
MA0122.3	Nkx3-2	MA0122.3	2.46e-07	0.000211
MA1994.1	Nkx2-1	MA1994.1	2.55e-07	0.000219
MA0592.3	ESRRA	MA0592.3	3.67e-07	0.000315
MA1651.1	ZFP42	MA1651.1	3.92e-07	0.000337
MA1561.1	SOX12	MA1561.1	4.28e-07	0.000368
MA0691.1	TFAP4	MA0691.1	4.43e-07	0.000381
MA1521.1	MAFA	MA1521.1	4.53e-07	0.000389
MA1147.1	NR4A2::RXRA	MA1147.1	5.23e-07	0.000449
MA0624.2	Nfatc1	MA0624.2	5.97e-07	0.000513
MA0868.2	SOX8	MA0868.2	6.46e-07	0.000555
MA0809.2	TEAD4	MA0809.2	6.95e-07	0.000597
MA0743.2	SCRT1	MA0743.2	7.49e-07	0.000643
MA1647.2	Prdm4	MA1647.2	7.6e-07	0.000653
MA1731.1	ZNF768	MA1731.1	7.76e-07	0.000667
MA0670.1	NFIA	MA0670.1	7.94e-07	0.000682
MA0687.1	SPIC	MA0687.1	8.22e-07	0.000706
MA0672.1	NKX2-3	MA0672.1	1.04e-06	0.000895
MA1524.2	Msgn1	MA1524.2	1.12e-06	0.000959
MA1979.1	ZNF416	MA1979.1	1.21e-06	0.00104
MA0610.1	DMRT3	MA0610.1	1.6e-06	0.00138
MA1623.1	Stat2	MA1623.1	1.7e-06	0.00146
MA1652.1	ZKSCAN5	MA1652.1	1.81e-06	0.00155
MA0669.1	NEUROG2	MA0669.1	1.94e-06	0.00167
MA1956.1	FOXO1::FLI1	MA1956.1	1.98e-06	0.0017
MA0619.1	LIN54	MA0619.1	2.26e-06	0.00194
MA0719.1	RHOXF1	MA0719.1	2.29e-06	0.00197
MA1574.1	THRB	MA1574.1	2.33e-06	0.002
MA1940.1	ETV2::DRGX	MA1940.1	2.35e-06	0.00202
MA0826.1	OLIG1	MA0826.1	2.59e-06	0.00222
MA0817.1	BHLHE23	MA0817.1	2.68e-06	0.0023
MA1150.1	RORB	MA1150.1	3.2e-06	0.00275
MA0827.1	OLIG3	MA0827.1	3.31e-06	0.00284
MA0160.2	NR4A2	MA0160.2	3.51e-06	0.00302
MA0065.2	Pparg::Rxra	MA0065.2	3.7e-06	0.00317
MA1937.1	ERF::HOXB13	MA1937.1	3.72e-06	0.00319
MA0664.1	MLXIPL	MA0664.1	4.1e-06	0.00352
MA1567.2	Tbx6	MA1567.2	4.25e-06	0.00365
MA0072.1	RORA	MA0072.1	5.16e-06	0.00443
MA0660.1	MEF2B	MA0660.1	5.31e-06	0.00456
MA1563.2	SOX18	MA1563.2	5.34e-06	0.00458
MA0690.2	TBX21	MA0690.2	5.96e-06	0.00512
MA0014.3	PAX5	MA0014.3	6.23e-06	0.00535
MA0711.1 (OTX1)	STREME-2	2-ATAATC	5.98e-38	0.0055
MA0518.1	Stat4	MA0518.1	6.82e-06	0.00586
MA0130.1	ZNF354C	MA0130.1	6.97e-06	0.00599
MA0651.2	HOXC11	MA0651.2	7.18e-06	0.00617
MA1998.1	Prdm14	MA1998.1	7.49e-06	0.00643
MA0643.1	Esrrg	MA0643.1	7.94e-06	0.00682
MA0681.2 (PHOX2B)	STREME-3	3-TCAAAT	7.9e-18	0.00808
MA0017.2	NR2F1	MA0017.2	9.69e-06	0.00832
MA0071.1	RORA	MA0071.1	1.09e-05	0.00939
MA0631.1	Six3	MA0631.1	1.15e-05	0.00986
MA0626.1	Npas2	MA0626.1	1.23e-05	0.0106
MA0114.4	HNF4A	MA0114.4	1.25e-05	0.0107
MA0137.3	STAT1	MA0137.3	1.27e-05	0.0109
MA1646.1	OSR2	MA1646.1	1.4e-05	0.012
MA0825.1	MNT	MA0825.1	1.51e-05	0.013
MA0069.1	PAX6	MA0069.1	1.59e-05	0.0136
MA1618.1	Ptf1a	MA1618.1	1.61e-05	0.0138
MA0507.2	POU2F2	MA0507.2	1.69e-05	0.0145
MA0056.2	MZF1	MA0056.2	1.72e-05	0.0147
4-ATCTAA	STREME-4	4-ATCTAA	3.39e-22	0.0181
MA1949.1	FLI1::DRGX	MA1949.1	2.13e-05	0.0183
MA1990.1	Gli1	MA1990.1	2.19e-05	0.0188
MA1146.1	NR1H4::RXRA	MA1146.1	2.22e-05	0.019
MA0090.3	TEAD1	MA0090.3	2.28e-05	0.0196
MA0006.1	Ahr::Arnt	MA0006.1	2.42e-05	0.0208
MA0843.1	TEF	MA0843.1	2.43e-05	0.0209
MA1108.2	MXI1	MA1108.2	2.51e-05	0.0216
MA1625.1	Stat5b	MA1625.1	2.67e-05	0.023
MA0058.3	MAX	MA0058.3	2.95e-05	0.0253
MA0505.2	Nr5A2	MA0505.2	3.01e-05	0.0258
MA1957.1	HOXB2::ELK1	MA1957.1	3.14e-05	0.0269
MA0036.3 (GATA2)	STREME-5	5-RDAGATAA	2.61e-50	0.0287
MA0484.2	HNF4G	MA0484.2	3.54e-05	0.0304
6-ATATCA	STREME-6	6-ATATCA	1.86e-35	0.0316
MA2003.1	NKX2-4	MA2003.1	3.81e-05	0.0327
MA0774.1	MEIS2	MA0774.1	4.16e-05	0.0358
MA1555.1 (RXRB)	STREME-7	7-CATGAC	3.14e-40	0.0361
MA0775.1	MEIS3	MA0775.1	4.8e-05	0.0412
MA0776.1	MYBL1	MA0776.1	5.27e-05	0.0452
MA1643.1 (NFIB)	MEME-6	GCCACCRYGCCYRGC	6.27e-21	0.046
MA1596.1 (ZNF460)	STREME-8	8-GCCTCAGCCTCCCA	4.05e-11	0.0472
MA0609.2	CREM	MA0609.2	5.73e-05	0.0492
MA1564.1	SP9	MA1564.1	5.78e-05	0.0497
9-KTCAAT	STREME-9	9-KTCAAT	9e-23	0.0617
MA1489.1 (FOXN3)	STREME-10	10-AAACAAA	1.86e-33	0.106
11-AGTGAA	STREME-11	11-AGTGAA	8.85e-20	0.122
MA0790.1 (POU4F1)	STREME-12	12-ATKMAT	4.42e-36	0.231

LR_open_xstreme %>%
  dplyr::select(SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>%
  arrange(.,EVALUE) %>%
   dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>%
  # dplyr::filter(., EVALUE<0.05) %>%
  kable(., caption = "Enriched motifs in LR_open") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "800px")

Enriched motifs in LR_open

SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
MA1134.1 (FOS::JUNB)	STREME-1	1-DATGASTCATH	3.3e-305	5.25e-305
MA1125.1 (ZNF384)	MEME-1	AAAWAAAAAAAAAAA	4.1e-229	6e-73
MA0477.2 (FOSL1)	MEME-2	TGAGTCAT	4.52e-305	2.4e-70
MA1634.1 (BATF)	STREME-2	2-NTGASTCAN	3.82e-305	4.73e-53
3-ATRTAYAT	STREME-3	3-ATRTAYAT	6.9e-303	5.97e-38
4-TGTAATC	STREME-4	4-TGTAATC	5.17e-269	3.02e-32
MA0817.1 (BHLHE23)	STREME-5	5-AAWCATAT	4.04e-305	3.83e-30
MA1632.1 (ATF2)	STREME-6	6-AAGTSATCH	4.27e-305	1.96e-28
7-AVTABT	STREME-7	7-AVTABT	1.59e-265	1.82e-24
8-WCATGW	STREME-8	8-WCATGW	1.55e-305	3.13e-22
9-AAYWRTT	STREME-9	9-AAYWRTT	6.27e-173	4.43e-22
10-TRTAYA	STREME-10	10-TRTAYA	5.08e-291	1.68e-18
MA1973.1 (ZKSCAN3)	MEME-3	CCAGCCTGGGYRACA	3.92e-118	4.3e-17
MA1107.2 (KLF9)	MEME-4	GTGTGTGTGTGTGTG	4.84e-43	8.3e-14
11-TAAGAMA	STREME-11	11-TAAGAMA	9.35e-305	4.66e-13
MA0041.2 (FOXD3)	MEME-5	AAAWGMAAAWWAAAA	7.97e-173	1.4e-09
MA1596.1 (ZNF460)	MEME-6	TTGGGAGGCYGAGGY	6.14e-119	6.3e-07
MA0682.2 (PITX1)	MEME-7	CCTGTAATCCCAGCA	4.02e-129	7.9e-06

LR_close_xstreme %>% 
  dplyr::select(SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
  arrange(.,EVALUE) %>%
   dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  # dplyr::filter(., EVALUE<0.05) %>% 
  kable(., caption = "Enriched motifs  in LR close") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "800px")

Enriched motifs in LR close

SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
MA0774.1	MEIS2	MA0774.1	5.29e-115	4.56e-112
MA0775.1	MEIS3	MA0775.1	8.3e-91	7.15e-88
MA0672.1	NKX2-3	MA0672.1	6.29e-87	5.41e-84
MA0673.1	NKX2-8	MA0673.1	1.93e-72	1.66e-69
MA2003.1	NKX2-4	MA2003.1	1.05e-65	9.04e-63
MA0498.2	MEIS1	MA0498.2	4.09e-56	3.52e-53
MA0797.1	TGIF2	MA0797.1	6.65e-55	5.72e-52
MA0738.1	HIC2	MA0738.1	1.11e-53	9.53e-51
MA0739.1	Hic1	MA0739.1	1.74e-53	1.5e-50
MA0766.2	GATA5	MA0766.2	1.49e-51	1.28e-48
MA0670.1	NFIA	MA0670.1	3.94e-50	3.4e-47
MA0626.1	Npas2	MA0626.1	1.06e-49	9.12e-47
MA1994.1	Nkx2-1	MA1994.1	2.02e-49	1.74e-46
MA0671.1	NFIX	MA0671.1	1.37e-44	1.18e-41
MA1615.1	Plagl1	MA1615.1	7.4e-43	6.37e-40
MA0161.2	NFIC	MA0161.2	1.95e-42	1.68e-39
MA0783.1	PKNOX2	MA0783.1	5.38e-40	4.63e-37
MA1108.2	MXI1	MA1108.2	4.6e-38	3.96e-35
MA0809.2	TEAD4	MA0809.2	4.89e-38	4.21e-35
MA1643.1	NFIB	MA1643.1	5.06e-38	4.35e-35
MA0092.1	Hand1::Tcf3	MA0092.1	8.33e-36	7.17e-33
MA0669.1	NEUROG2	MA0669.1	1.14e-35	9.85e-33
MA0036.3	GATA2	MA0036.3	5.26e-35	4.53e-32
MA1641.1	MYF5	MA1641.1	8.45e-35	7.27e-32
MA1986.1	ZNF692	MA1986.1	1.79e-34	1.54e-31
MA1571.1	TGIF2LX	MA1571.1	5.51e-34	4.74e-31
MA0499.2	MYOD1	MA0499.2	2.26e-33	1.94e-30
MA1631.1	ASCL1	MA1631.1	2.86e-33	2.46e-30
MA1979.1	ZNF416	MA1979.1	6.24e-33	5.37e-30
MA0090.3	TEAD1	MA0090.3	1.63e-32	1.4e-29
MA0140.2	GATA1::TAL1	MA0140.2	4.39e-32	3.78e-29
MA0623.2	NEUROG1	MA0623.2	5.56e-32	4.79e-29
MA0808.1	TEAD3	MA0808.1	2.62e-31	2.26e-28
MA0667.1	MYF6	MA0667.1	1.49e-30	1.28e-27
MA0633.2	Twist2	MA0633.2	4.03e-30	3.47e-27
MA0830.2	TCF4	MA0830.2	4.34e-30	3.73e-27
MA0607.2	BHLHA15	MA0607.2	8.9e-30	7.66e-27
MA1997.1	Olig2	MA1997.1	1.37e-29	1.18e-26
MA0796.1	TGIF1	MA0796.1	1.63e-29	1.4e-26
MA0597.2	THAP1	MA0597.2	2.64e-29	2.27e-26
MA0060.3	NFYA	MA0060.3	4.78e-29	4.12e-26
MA0741.1	KLF16	MA0741.1	6.95e-29	5.99e-26
MA1472.2	Bhlha15	MA1472.2	1.34e-28	1.16e-25
MA1656.1	ZNF449	MA1656.1	2.13e-28	1.83e-25
MA1730.1	ZNF708	MA1730.1	2.16e-28	1.86e-25
MA1645.1	NKX2-2	MA1645.1	2.42e-28	2.08e-25
MA1993.1	Neurod2	MA1993.1	2.52e-28	2.17e-25
MA0826.1	OLIG1	MA0826.1	2.38e-27	2.05e-24
MA1102.2	CTCFL	MA1102.2	2.84e-27	2.44e-24
MA1599.1	ZNF682	MA1599.1	1.36e-26	1.17e-23
MA0039.4	KLF4	MA0039.4	2.42e-26	2.08e-23
MA1719.1	ZNF816	MA1719.1	7.92e-26	6.82e-23
MA1982.1	ZNF574	MA1982.1	8.83e-26	7.61e-23
MA0070.1	PBX1	MA0070.1	1.73e-25	1.49e-22
MA0698.1	ZBTB18	MA0698.1	2.64e-25	2.27e-22
MA0048.2	NHLH1	MA0048.2	2.93e-25	2.53e-22
MA0063.2	NKX2-5	MA0063.2	3.71e-25	3.19e-22
MA1572.1	TGIF2LY	MA1572.1	3.77e-25	3.24e-22
MA1635.1	BHLHE22	MA1635.1	4.31e-25	3.71e-22
MA1726.1	ZNF331	MA1726.1	8.16e-25	7.02e-22
MA0817.1	BHLHE23	MA0817.1	1.14e-24	9.81e-22
MA0810.1	TFAP2A	MA0810.1	1.35e-24	1.16e-21
MA0816.1	Ascl2	MA0816.1	1.41e-24	1.21e-21
MA1468.1	ATOH7	MA1468.1	1.63e-24	1.41e-21
MA1125.1 (ZNF384)	MEME-1	AAAWAAAAAWAAAAA	0.788	1.5e-21
MA1650.1	ZBTB14	MA1650.1	4e-24	3.44e-21
MA0122.3	Nkx3-2	MA0122.3	6.35e-24	5.47e-21
MA1712.1	ZNF454	MA1712.1	1.31e-23	1.13e-20
MA1629.1	Zic2	MA1629.1	3.23e-23	2.78e-20
MA1578.1	VEZF1	MA1578.1	3.52e-23	3.03e-20
MA1515.1	KLF2	MA1515.1	5.16e-23	4.45e-20
MA1619.1	Ptf1A	MA1619.1	1.18e-22	1.01e-19
MA0697.2	Zic3	MA0697.2	1.18e-22	1.02e-19
MA1620.1	Ptf1A	MA1620.1	1.43e-22	1.23e-19
MA1107.2	KLF9	MA1107.2	1.99e-22	1.71e-19
MA1558.1	SNAI1	MA1558.1	2.94e-22	2.54e-19
MA1621.1	Rbpjl	MA1621.1	3.8e-22	3.27e-19
MA0502.2	NFYB	MA0502.2	5.14e-22	4.43e-19
MA0914.1	ISL2	MA0914.1	5.86e-22	5.05e-19
MA0521.2	Tcf12	MA0521.2	8.3e-22	7.14e-19
MA0818.2	BHLHE22	MA0818.2	1.13e-21	9.74e-19
MA1566.2	TBX3	MA1566.2	1.21e-21	1.04e-18
MA1974.1	ZNF211	MA1974.1	2.12e-21	1.82e-18
MA0130.1	ZNF354C	MA0130.1	2.54e-21	2.19e-18
MA0745.2	SNAI2	MA0745.2	2.84e-21	2.44e-18
MA0747.1	SP8	MA0747.1	5.54e-21	4.77e-18
MA0811.1	TFAP2B	MA0811.1	6.98e-21	6.01e-18
MA0018.4	CREB1	MA0018.4	7.28e-21	6.27e-18
MA0691.1	TFAP4	MA0691.1	8.67e-21	7.46e-18
MA1581.1	ZBTB6	MA1581.1	9.52e-21	8.2e-18
MA0147.3	MYC	MA0147.3	9.61e-21	8.27e-18
MA0678.1	OLIG2	MA0678.1	1.08e-20	9.27e-18
MA1644.1	NFYC	MA1644.1	1.83e-20	1.57e-17
MA0821.2	HES5	MA0821.2	1.85e-20	1.59e-17
MA1655.1	ZNF341	MA1655.1	2.11e-20	1.81e-17
MA1100.2	ASCL1	MA1100.2	2.12e-20	1.83e-17
MA0734.3	Gli2	MA0734.3	2.66e-20	2.29e-17
MA1570.1	TFAP4	MA1570.1	2.97e-20	2.56e-17
MA0103.3	ZEB1	MA0103.3	4.69e-20	4.04e-17
MA1153.1	Smad4	MA1153.1	4.85e-20	4.18e-17
MA1959.1	KLF7	MA1959.1	5.09e-20	4.38e-17
MA1564.1	SP9	MA1564.1	8.28e-20	7.13e-17
MA1653.1	ZNF148	MA1653.1	1.25e-19	1.07e-16
MA1623.1 (Stat2)	MEME-2	TYYYTYTYTYTCTYT	0.105	1.5e-16
MA1567.2	Tbx6	MA1567.2	1.8e-19	1.55e-16
MA1628.1	Zic1::Zic2	MA1628.1	1.97e-19	1.69e-16
MA0471.2	E2F6	MA0471.2	2.74e-19	2.36e-16
MA0003.4	TFAP2A	MA0003.4	5.17e-19	4.45e-16
MA0500.2	MYOG	MA0500.2	6.44e-19	5.54e-16
MA1563.2	SOX18	MA1563.2	8.58e-19	7.39e-16
MA1121.1	TEAD2	MA1121.1	9.7e-19	8.35e-16
MA1648.1	TCF12	MA1648.1	1.17e-18	1.01e-15
MA0802.1	TBR1	MA0802.1	1.29e-18	1.11e-15
MA1112.2	NR4A1	MA1112.2	1.58e-18	1.36e-15
MA0524.2	TFAP2C	MA0524.2	1.87e-18	1.61e-15
MA1547.2	PITX2	MA1547.2	1.96e-18	1.69e-15
MA0820.1	FIGLA	MA0820.1	2.7e-18	2.33e-15
MA0709.1	Msx3	MA0709.1	3.64e-18	3.13e-15
MA0789.1	POU3F4	MA0789.1	4e-18	3.44e-15
MA1123.2	TWIST1	MA1123.2	5.22e-18	4.49e-15
MA0688.1	TBX2	MA0688.1	5.24e-18	4.52e-15
MA1524.2	Msgn1	MA1524.2	5.38e-18	4.63e-15
MA0807.1	TBX5	MA0807.1	7.68e-18	6.61e-15
MA1981.1	ZNF530	MA1981.1	8.06e-18	6.94e-15
MA1990.1	Gli1	MA1990.1	8.18e-18	7.05e-15
MA0814.2	TFAP2C	MA0814.2	2.03e-17	1.75e-14
MA1109.1	NEUROD1	MA1109.1	2.29e-17	1.97e-14
MA0896.1	Hmx1	MA0896.1	2.91e-17	2.51e-14
MA0119.1	NFIC::TLX1	MA0119.1	2.94e-17	2.53e-14
MA0006.1	Ahr::Arnt	MA0006.1	3.23e-17	2.78e-14
MA1618.1	Ptf1a	MA1618.1	4.14e-17	3.57e-14
MA0033.2	FOXL1	MA0033.2	4.32e-17	3.72e-14
MA1724.1	Rfx6	MA1724.1	4.47e-17	3.84e-14
MA0792.1	POU5F1B	MA0792.1	5.36e-17	4.62e-14
MA0827.1	OLIG3	MA0827.1	6.64e-17	5.71e-14
MA1122.1	TFDP1	MA1122.1	7.23e-17	6.22e-14
MA0654.1	ISX	MA0654.1	8.65e-17	7.45e-14
MA0091.1	TAL1::TCF3	MA0091.1	1.33e-16	1.14e-13
MA0800.1	EOMES	MA0800.1	1.48e-16	1.27e-13
MA0493.2	KLF1	MA0493.2	1.56e-16	1.35e-13
MA0646.1	GCM1	MA0646.1	1.71e-16	1.47e-13
MA0803.1	TBX15	MA0803.1	1.99e-16	1.71e-13
MA0146.2	Zfx	MA0146.2	2e-16	1.72e-13
MA0812.1	TFAP2B	MA0812.1	2.2e-16	1.9e-13
MA0154.4	EBF1	MA0154.4	2.24e-16	1.93e-13
MA0258.2	ESR2	MA0258.2	4.47e-16	3.85e-13
MA0666.2	MSX1	MA0666.2	6.21e-16	5.35e-13
MA0665.1	MSC	MA0665.1	8.28e-16	7.13e-13
MA1723.1	PRDM9	MA1723.1	8.32e-16	7.16e-13
MA0912.2	HOXD3	MA0912.2	1.1e-15	9.47e-13
MA1593.1	ZNF317	MA1593.1	1.13e-15	9.72e-13
MA0751.1	ZIC4	MA0751.1	1.2e-15	1.03e-12
MA0482.2	GATA4	MA0482.2	2.4e-15	2.06e-12
MA1522.1	MAZ	MA1522.1	2.44e-15	2.1e-12
MA1514.1	KLF17	MA1514.1	2.47e-15	2.13e-12
MA0664.1	MLXIPL	MA0664.1	2.78e-15	2.39e-12
MA0145.2	Tfcp2l1	MA0145.2	3.16e-15	2.72e-12
MA0596.1	SREBF2	MA0596.1	3.26e-15	2.81e-12
MA1500.1	HOXB6	MA1500.1	3.88e-15	3.34e-12
MA2002.1	Zfp335	MA2002.1	3.95e-15	3.4e-12
MA0904.2	HOXB5	MA0904.2	4.22e-15	3.63e-12
MA0124.2	Nkx3-1	MA0124.2	4.97e-15	4.28e-12
MA1731.1	ZNF768	MA1731.1	6.41e-15	5.52e-12
MA0767.1	GCM2	MA0767.1	6.54e-15	5.63e-12
MA1527.1	NFIC	MA1527.1	7.09e-15	6.11e-12
MA1638.1	HAND2	MA1638.1	7.23e-15	6.22e-12
MA0782.2	PKNOX1	MA0782.2	1.04e-14	8.94e-12
MA0806.1	TBX4	MA0806.1	1.17e-14	1.01e-11
MA0158.2	HOXA5	MA0158.2	1.24e-14	1.07e-11
MA0674.1	NKX6-1	MA0674.1	1.26e-14	1.08e-11
MA1637.1	EBF3	MA1637.1	1.85e-14	1.59e-11
MA0668.2	Neurod2	MA0668.2	2.27e-14	1.95e-11
MA1627.1	Wt1	MA1627.1	3.08e-14	2.65e-11
MA0825.1	MNT	MA0825.1	3.13e-14	2.7e-11
MA1493.1	HES6	MA1493.1	3.55e-14	3.05e-11
MA0522.3	TCF3	MA0522.3	3.65e-14	3.15e-11
MA0644.2	ESX1	MA0644.2	4.07e-14	3.5e-11
MA0523.1	TCF7L2	MA0523.1	5.07e-14	4.36e-11
MA0461.2	Atoh1	MA0461.2	5.95e-14	5.13e-11
MA0724.1	VENTX	MA0724.1	6.2e-14	5.33e-11
MA0052.4	MEF2A	MA0052.4	6.27e-14	5.4e-11
MA1151.1	RORC	MA1151.1	6.29e-14	5.42e-11
MA0618.1	LBX1	MA0618.1	6.61e-14	5.69e-11
MA0160.2	NR4A2	MA0160.2	6.67e-14	5.74e-11
MA1479.1	DMRTC2	MA1479.1	7.02e-14	6.04e-11
MA0601.1	Arid3b	MA0601.1	7.44e-14	6.41e-11
MA1499.1	HOXB4	MA1499.1	7.75e-14	6.67e-11
MA0614.1	Foxj2	MA0614.1	8.34e-14	7.18e-11
MA1505.1	HOXC8	MA1505.1	8.7e-14	7.49e-11
MA0701.2	LHX9	MA0701.2	8.72e-14	7.51e-11
MA1560.1	SOHLH2	MA1560.1	1.01e-13	8.73e-11
MA0071.1	RORA	MA0071.1	1.06e-13	9.11e-11
MA0058.3	MAX	MA0058.3	1.18e-13	1.01e-10
MA0708.2	MSX2	MA0708.2	1.22e-13	1.05e-10
MA1517.1	KLF6	MA1517.1	1.37e-13	1.18e-10
MA0649.1	HEY2	MA0649.1	1.48e-13	1.27e-10
MA0065.2	Pparg::Rxra	MA0065.2	1.71e-13	1.47e-10
MA1710.1	ZNF257	MA1710.1	1.76e-13	1.52e-10
MA0151.1	Arid3a	MA0151.1	2.33e-13	2.01e-10
MA1502.1	HOXB8	MA1502.1	3.05e-13	2.62e-10
MA0093.3	USF1	MA0093.3	3.34e-13	2.88e-10
MA0876.1	BSX	MA0876.1	4.6e-13	3.96e-10
MA0805.1	TBX1	MA0805.1	6.3e-13	5.42e-10
MA0889.1	GBX1	MA0889.1	6.86e-13	5.9e-10
MA1720.1	ZNF85	MA1720.1	1.03e-12	8.9e-10
MA0707.2	MNX1	MA0707.2	1.06e-12	9.09e-10
MA1642.1	NEUROG2	MA1642.1	1.22e-12	1.05e-09
MA1977.1 (ZNF324)	MEME-3	MHTBCCWGCMTBCYH	1.25e-21	1.1e-09
MA0881.1	Dlx4	MA0881.1	1.28e-12	1.11e-09
MA1573.2	Thap11	MA1573.2	1.68e-12	1.45e-09
MA0910.2	HOXD8	MA0910.2	1.9e-12	1.64e-09
MA0865.2	E2F8	MA0865.2	2.08e-12	1.79e-09
MA1579.1	ZBTB26	MA1579.1	2.23e-12	1.92e-09
MA0900.2	HOXA2	MA0900.2	2.36e-12	2.03e-09
MA1963.1	SATB1	MA1963.1	2.37e-12	2.04e-09
MA0690.2	TBX21	MA0690.2	2.74e-12	2.36e-09
MA0125.1	Nobox	MA0125.1	2.91e-12	2.51e-09
MA0692.1	TFEB	MA0692.1	4.08e-12	3.51e-09
MA1115.1	POU5F1	MA1115.1	4.48e-12	3.86e-09
MA1583.1	ZFP57	MA1583.1	5.18e-12	4.46e-09
MA1476.2	Dlx5	MA1476.2	6.99e-12	6.02e-09
MA1987.1	ZNF701	MA1987.1	7.1e-12	6.12e-09
MA0842.2	NRL	MA0842.2	7.38e-12	6.35e-09
MA0141.3	ESRRB	MA0141.3	8.17e-12	7.04e-09
MA0610.1	DMRT3	MA0610.1	8.34e-12	7.18e-09
MA0259.1	ARNT::HIF1A	MA0259.1	8.42e-12	7.25e-09
MA0704.1	Lhx4	MA0704.1	8.85e-12	7.62e-09
MA1707.1	DMRTA1	MA1707.1	1.14e-11	9.83e-09
MA1976.1	ZNF320	MA1976.1	1.14e-11	9.85e-09
MA1104.2	GATA6	MA1104.2	1.26e-11	1.09e-08
MA0630.1	SHOX	MA0630.1	1.31e-11	1.13e-08
MA1149.1	RARA::RXRG	MA1149.1	1.35e-11	1.16e-08
MA1511.2	KLF10	MA1511.2	1.35e-11	1.16e-08
MA0788.1	POU3F3	MA0788.1	1.71e-11	1.47e-08
MA1966.1	TFAP4::ETV1	MA1966.1	1.84e-11	1.58e-08
MA1652.1	ZKSCAN5	MA1652.1	2.1e-11	1.81e-08
MA1972.1	ZFP14	MA1972.1	2.19e-11	1.89e-08
MA0511.2	RUNX2	MA0511.2	2.37e-11	2.04e-08
MA0132.2	PDX1	MA0132.2	2.38e-11	2.05e-08
MA1523.1	MSANTD3	MA1523.1	2.48e-11	2.14e-08
MA0627.2	POU2F3	MA0627.2	2.6e-11	2.24e-08
MA0670.1 (NFIA)	STREME-1	1-RTGCCA	4.29e-106	2.52e-08
MA0902.2	HOXB2	MA0902.2	2.94e-11	2.53e-08
MA0786.1	POU3F1	MA0786.1	3.3e-11	2.84e-08
MA0722.1	VAX1	MA0722.1	3.45e-11	2.97e-08
MA0675.1	NKX6-2	MA0675.1	3.85e-11	3.31e-08
MA0634.1	ALX3	MA0634.1	4.15e-11	3.57e-08
MA0700.2	LHX2	MA0700.2	4.4e-11	3.79e-08
MA1535.1	NR2C1	MA1535.1	5.1e-11	4.39e-08
MA0631.1	Six3	MA0631.1	5.63e-11	4.84e-08
MA1941.1	ETV2::FIGLA	MA1941.1	6.07e-11	5.22e-08
MA0612.2	EMX1	MA0612.2	6.39e-11	5.5e-08
MA1507.1	HOXD4	MA1507.1	7.32e-11	6.3e-08
MA0035.4	GATA1	MA0035.4	7.38e-11	6.36e-08
MA1463.1	ARGFX	MA1463.1	7.57e-11	6.52e-08
MA1528.1	NFIX	MA1528.1	7.68e-11	6.61e-08
MA0689.1	TBX20	MA0689.1	8.13e-11	7e-08
MA1604.1	Ebf2	MA1604.1	8.7e-11	7.49e-08
MA0726.1	VSX2	MA0726.1	8.95e-11	7.71e-08
MA0743.2	SCRT1	MA0743.2	9.1e-11	7.84e-08
MA0899.1	HOXA10	MA0899.1	1.23e-10	1.06e-07
MA0592.3	ESRRA	MA0592.3	1.33e-10	1.15e-07
MA1632.1	ATF2	MA1632.1	1.42e-10	1.22e-07
MA0753.2	ZNF740	MA0753.2	1.46e-10	1.25e-07
MA1984.1	ZNF667	MA1984.1	1.94e-10	1.67e-07
MA0720.1	Shox2	MA0720.1	2.44e-10	2.1e-07
MA0832.1	Tcf21	MA0832.1	2.46e-10	2.12e-07
MA1721.1	ZNF93	MA1721.1	2.81e-10	2.42e-07
MA1519.1	LHX5	MA1519.1	3.44e-10	2.96e-07
MA0084.1	SRY	MA0084.1	3.47e-10	2.99e-07
MA1651.1	ZFP42	MA1651.1	3.5e-10	3.01e-07
MA0479.1	FOXH1	MA0479.1	3.5e-10	3.01e-07
MA0650.3	Hoxa13	MA0650.3	4.36e-10	3.75e-07
MA1973.1	ZKSCAN3	MA1973.1	4.85e-10	4.18e-07
MA1512.1	KLF11	MA1512.1	5.46e-10	4.7e-07
MA0885.2	Dlx2	MA0885.2	5.47e-10	4.71e-07
MA1975.1	ZNF214	MA1975.1	5.5e-10	4.74e-07
MA1649.1	ZBTB12	MA1649.1	5.75e-10	4.95e-07
MA1646.1	OSR2	MA1646.1	6.84e-10	5.89e-07
MA1504.1	HOXC4	MA1504.1	7.11e-10	6.12e-07
MA0695.1	ZBTB7C	MA0695.1	7.6e-10	6.54e-07
MA1540.2	NR5A1	MA1540.2	9.07e-10	7.81e-07
MA0027.2	EN1	MA0027.2	9.36e-10	8.06e-07
MA0075.3	PRRX2	MA0075.3	1.04e-09	8.95e-07
MA1480.1	DPRX	MA1480.1	1.06e-09	9.14e-07
MA1562.1	SOX14	MA1562.1	1.07e-09	9.23e-07
MA1978.1	ZNF354A	MA1978.1	1.14e-09	9.85e-07
MA0909.3	Hoxd13	MA0909.3	1.21e-09	1.05e-06
MA0079.5	SP1	MA0079.5	1.39e-09	1.2e-06
MA0031.1	FOXD1	MA0031.1	1.49e-09	1.28e-06
MA0787.1	POU3F2	MA0787.1	1.49e-09	1.28e-06
MA0783.1 (PKNOX2)	STREME-2	2-CCTGTCA	7.9e-136	1.43e-06
MA0117.2	Mafb	MA0117.2	2.03e-09	1.75e-06
MA0740.2	KLF14	MA0740.2	2.19e-09	1.88e-06
MA0505.2	Nr5A2	MA0505.2	2.28e-09	1.96e-06
MA0901.2	HOXB13	MA0901.2	2.74e-09	2.36e-06
MA1487.2	FOXE1	MA1487.2	2.77e-09	2.38e-06
MA0143.4	SOX2	MA0143.4	3.63e-09	3.12e-06
MA0712.2	OTX2	MA0712.2	3.72e-09	3.2e-06
MA0716.1	PRRX1	MA0716.1	3.72e-09	3.2e-06
MA0897.1	Hmx2	MA0897.1	3.84e-09	3.31e-06
MA0890.1	GBX2	MA0890.1	3.94e-09	3.39e-06
MA0483.1	Gfi1B	MA0483.1	4.02e-09	3.47e-06
MA0719.1	RHOXF1	MA0719.1	4.46e-09	3.84e-06
MA0713.1	PHOX2A	MA0713.1	4.69e-09	4.04e-06
MA0725.1	VSX1	MA0725.1	4.81e-09	4.14e-06
MA1111.1	NR2F2	MA1111.1	5.25e-09	4.52e-06
MA0602.1	Arid5a	MA0602.1	5.52e-09	4.75e-06
MA0014.3	PAX5	MA0014.3	5.52e-09	4.75e-06
MA1559.1	SNAI3	MA1559.1	5.88e-09	5.06e-06
MA0886.1	EMX2	MA0886.1	5.94e-09	5.11e-06
MA1467.2	Atoh1	MA1467.2	6.04e-09	5.2e-06
MA0705.1	Lhx8	MA0705.1	6.13e-09	5.28e-06
MA0660.1	MEF2B	MA0660.1	6.29e-09	5.41e-06
MA0880.1	Dlx3	MA0880.1	6.36e-09	5.48e-06
MA0898.1	Hmx3	MA0898.1	6.42e-09	5.53e-06
MA1548.1	PLAGL2	MA1548.1	6.57e-09	5.65e-06
MA0845.1	FOXB1	MA0845.1	6.6e-09	5.68e-06
MA0077.1	SOX9	MA0077.1	7.4e-09	6.37e-06
MA0078.2	Sox17	MA0078.2	7.58e-09	6.53e-06
MA1574.1	THRB	MA1574.1	7.76e-09	6.68e-06
MA0790.1	POU4F1	MA0790.1	7.94e-09	6.84e-06
MA0025.2	NFIL3	MA0025.2	7.96e-09	6.86e-06
MA1119.1	SIX2	MA1119.1	8.09e-09	6.97e-06
MA1518.2	Lhx1	MA1518.2	8.13e-09	7e-06
MA0744.2	SCRT2	MA0744.2	8.16e-09	7.03e-06
MA1114.1	PBX3	MA1114.1	8.33e-09	7.17e-06
MA0801.1	MGA	MA0801.1	8.4e-09	7.23e-06
MA1991.1	Hnf1A	MA1991.1	1.09e-08	9.42e-06
MA0710.1	NOTO	MA0710.1	1.13e-08	9.77e-06
MA1561.1	SOX12	MA1561.1	1.25e-08	1.07e-05
MA0492.1	JUND	MA0492.1	1.4e-08	1.21e-05
MA0111.1	Spz1	MA0111.1	1.46e-08	1.26e-05
MA1601.2	ZNF75D	MA1601.2	1.46e-08	1.26e-05
MA0723.2	VAX2	MA0723.2	1.49e-08	1.28e-05
MA1713.1	ZNF610	MA1713.1	1.52e-08	1.31e-05
MA0037.4	Gata3	MA0037.4	1.95e-08	1.68e-05
MA1536.1	NR2C2	MA1536.1	2.01e-08	1.73e-05
MA0162.4	EGR1	MA0162.4	2.04e-08	1.75e-05
MA0718.1	RAX	MA0718.1	2.05e-08	1.77e-05
MA1580.1	ZBTB32	MA1580.1	2.12e-08	1.83e-05
MA1603.1	Dmrt1	MA1603.1	2.37e-08	2.04e-05
MA0785.1	POU2F1	MA0785.1	2.67e-08	2.3e-05
MA1989.1	Bcl11B	MA1989.1	3.02e-08	2.6e-05
MA0750.2	ZBTB7A	MA0750.2	3.1e-08	2.67e-05
MA0599.1	KLF5	MA0599.1	3.12e-08	2.69e-05
MA0662.1	MIXL1	MA0662.1	3.76e-08	3.24e-05
MA0108.2	TBP	MA0108.2	3.99e-08	3.43e-05
MA1148.1	PPARA::RXRA	MA1148.1	4.48e-08	3.86e-05
MA0442.2	SOX10	MA0442.2	4.96e-08	4.27e-05
MA0494.1	Nr1h3::Rxra	MA0494.1	5.61e-08	4.83e-05
MA0748.2	YY2	MA0748.2	6.79e-08	5.84e-05
MA1996.1	Nr1H2	MA1996.1	7.2e-08	6.2e-05
MA1998.1	Prdm14	MA1998.1	7.23e-08	6.22e-05
MA0857.1	Rarb	MA0857.1	7.28e-08	6.27e-05
MA0609.2	CREM	MA0609.2	7.3e-08	6.28e-05
MA0756.2	ONECUT2	MA0756.2	7.49e-08	6.45e-05
MA1481.1	DRGX	MA1481.1	7.57e-08	6.52e-05
MA0087.2	Sox5	MA0087.2	7.86e-08	6.77e-05
MA0504.1	NR2C2	MA0504.1	9.06e-08	7.8e-05
MA0791.1	POU4F3	MA0791.1	9.17e-08	7.89e-05
MA0882.1	DLX6	MA0882.1	9.4e-08	8.09e-05
MA1531.1	NR1D1	MA1531.1	1.06e-07	9.16e-05
MA0528.2	ZNF263	MA0528.2	1.19e-07	0.000102
MA0860.1	Rarg	MA0860.1	1.34e-07	0.000115
MA0642.2	EN2	MA0642.2	1.4e-07	0.00012
MA1624.1	Stat5a	MA1624.1	1.61e-07	0.000138
MA0104.4	MYCN	MA0104.4	1.62e-07	0.00014
MA1501.1	HOXB7	MA1501.1	1.84e-07	0.000159
MA1715.1	ZNF707	MA1715.1	1.85e-07	0.000159
MA1683.1	FOXA3	MA1683.1	1.86e-07	0.00016
MA1970.1	TRPS1	MA1970.1	1.86e-07	0.000161
MA0833.2	ATF4	MA0833.2	1.91e-07	0.000164
MA0516.3	SP2	MA0516.3	1.97e-07	0.00017
MA0488.1	JUN	MA0488.1	1.98e-07	0.00017
MA1474.1	CREB3L4	MA1474.1	2e-07	0.000172
MA0843.1	TEF	MA0843.1	2.07e-07	0.000178
MA0714.1	PITX3	MA0714.1	2.07e-07	0.000178
MA1968.1	TFCP2	MA1968.1	2.07e-07	0.000178
MA0643.1	Esrrg	MA0643.1	2.15e-07	0.000185
MA0102.4	CEBPA	MA0102.4	2.29e-07	0.000197
MA1568.1	TCF21	MA1568.1	2.46e-07	0.000212
MA1516.1	KLF3	MA1516.1	2.97e-07	0.000255
MA0661.1	MEOX1	MA0661.1	3.27e-07	0.000281
MA1727.1	ZNF417	MA1727.1	3.48e-07	3e-04
MA0465.2	CDX2	MA0465.2	3.58e-07	0.000309
MA1594.1	ZNF382	MA1594.1	3.8e-07	0.000327
MA0083.3	SRF	MA0083.3	3.92e-07	0.000337
MA1541.1	NR6A1	MA1541.1	4.05e-07	0.000348
MA0866.1	SOX21	MA0866.1	4.18e-07	0.00036
MA0159.1	RARA::RXRA	MA0159.1	4.64e-07	0.000399
MA1557.1	SMAD5	MA1557.1	4.77e-07	0.000411
MA0009.2	TBXT	MA0009.2	4.94e-07	0.000425
MA0514.2	Sox3	MA0514.2	4.99e-07	0.00043
MA0905.1	HOXC10	MA0905.1	5.32e-07	0.000458
3-ACAKAGCA	STREME-3	3-ACAKAGCA	4.72e-56	0.000462
MA1929.1	CTCF	MA1929.1	5.47e-07	0.000471
MA1960.1	MGA::EVX1	MA1960.1	5.54e-07	0.000477
MA0846.1	FOXC2	MA0846.1	6.72e-07	0.000578
MA0002.2	Runx1	MA0002.2	7.49e-07	0.000645
4-CACACAG	STREME-4	4-CACACAG	3.15e-70	0.000855
MA1421.1	TCF7L1	MA1421.1	1.06e-06	0.000915
MA0717.1	RAX2	MA0717.1	1.14e-06	0.000984
MA0868.2	SOX8	MA0868.2	1.19e-06	0.00102
MA0645.1	ETV6	MA0645.1	1.22e-06	0.00105
MA1992.1	Ikzf3	MA1992.1	1.23e-06	0.00106
MA0851.1	Foxj3	MA0851.1	1.32e-06	0.00114
MA1152.1	SOX15	MA1152.1	1.36e-06	0.00117
MA0043.3	HLF	MA0043.3	1.4e-06	0.0012
MA0848.1	FOXO4	MA0848.1	1.41e-06	0.00121
MA1964.1	SMAD2	MA1964.1	1.5e-06	0.0013
MA1497.1	HOXA6	MA1497.1	1.76e-06	0.00152
MA0721.1	UNCX	MA0721.1	1.85e-06	0.00159
MA0090.3 (TEAD1)	STREME-5	5-CATTCCA	2.35e-45	0.00181
MA1965.1	SP5	MA1965.1	2.64e-06	0.00228
MA0875.1	BARX1	MA0875.1	2.69e-06	0.00232
6-CTCTCAG	STREME-6	6-CTCTCAG	1.13e-32	0.00237
MA0595.1	SREBF1	MA0595.1	3.01e-06	0.00259
MA0761.2	ETV1	MA0761.2	3.36e-06	0.00289
MA0041.2	FOXD3	MA0041.2	3.93e-06	0.00339
MA0628.1	POU6F1	MA0628.1	4.12e-06	0.00354
MA0467.2	Crx	MA0467.2	4.29e-06	0.00369
MA1120.1	SOX13	MA1120.1	4.35e-06	0.00374
MA1636.1	CEBPG	MA1636.1	4.63e-06	0.00399
MA0032.2	FOXC1	MA0032.2	4.68e-06	0.00403
7-ATGGGAG	STREME-7	7-ATGGGAG	6.39e-31	0.00463
MA0763.1	ETV3	MA0763.1	5.55e-06	0.00478
MA1977.1	ZNF324	MA1977.1	5.67e-06	0.00488
MA0148.4	FOXA1	MA0148.4	6.05e-06	0.00521
MA0495.3	MAFF	MA0495.3	6.09e-06	0.00524
MA1534.1	NR1I3	MA1534.1	6.48e-06	0.00558
MA0635.1	BARHL2	MA0635.1	6.78e-06	0.00584
MA0743.2 (SCRT1)	STREME-8	8-STGTTGA	5.54e-53	0.00597
MA0679.2	ONECUT1	MA0679.2	7.21e-06	0.00621
MA0620.3	MITF	MA0620.3	8.56e-06	0.00737
MA0831.3	TFE3	MA0831.3	8.75e-06	0.00753
MA1554.1	RFX7	MA1554.1	8.83e-06	0.0076
MA1475.1	CREB3L4	MA1475.1	9e-06	0.00775
MA0685.2	SP4	MA0685.2	9.15e-06	0.00788
MA1969.1	THRA	MA1969.1	9.47e-06	0.00815
MA0042.2	FOXI1	MA0042.2	9.5e-06	0.00818
MA0680.2	Pax7	MA0680.2	9.63e-06	0.00829
MA0847.3	FOXD2	MA0847.3	9.74e-06	0.00839
MA0733.1	EGR4	MA0733.1	1.05e-05	0.00908
MA0849.1	FOXO6	MA0849.1	1.07e-05	0.00918
MA0858.1	Rarb	MA0858.1	1.07e-05	0.0092
MA0804.1	TBX19	MA0804.1	1.11e-05	0.00959
MA0136.3	Elf5	MA0136.3	1.14e-05	0.00983
MA0497.1	MEF2C	MA0497.1	1.25e-05	0.0108
MA0017.2	NR2F1	MA0017.2	1.29e-05	0.0111
MA0518.1	Stat4	MA0518.1	1.3e-05	0.0112
MA0769.2	TCF7	MA0769.2	1.31e-05	0.0113
MA0891.1	GSC2	MA0891.1	1.44e-05	0.0124
MA0059.1	MAX::MYC	MA0059.1	1.51e-05	0.013
MA1983.1	ZNF582	MA1983.1	1.55e-05	0.0133
9-CCCAGC	STREME-9	9-CCCAGC	7.4e-41	0.0144
10-CCAGAGT	STREME-10	10-CCAGAGT	2.61e-49	0.0146
MA0682.2	PITX1	MA0682.2	1.73e-05	0.0149
MA0888.1	EVX2	MA0888.1	1.76e-05	0.0151
MA1606.1	Foxf1	MA1606.1	1.8e-05	0.0155
MA0887.1	EVX1	MA0887.1	1.81e-05	0.0156
MA0047.3	FOXA2	MA0047.3	2.04e-05	0.0175
MA0711.1	OTX1	MA0711.1	2.05e-05	0.0177
MA1110.2	Nr1H4	MA1110.2	2.14e-05	0.0184
MA1549.1	POU6F1	MA1549.1	2.21e-05	0.0191
MA0892.1	GSX1	MA0892.1	2.22e-05	0.0191
MA1537.1	NR2F1	MA1537.1	2.27e-05	0.0195
MA1116.1	RBPJ	MA1116.1	2.37e-05	0.0204
MA1718.1	ZNF8	MA1718.1	2.56e-05	0.0221
MA1129.1	FOSL1::JUN	MA1129.1	2.57e-05	0.0221
MA0684.2	RUNX3	MA0684.2	2.63e-05	0.0227
MA1640.1	MEIS2	MA1640.1	2.69e-05	0.0232
MA0867.2	SOX4	MA0867.2	2.77e-05	0.0238
MA1127.1	FOSB::JUN	MA1127.1	3.06e-05	0.0263
MA0699.1	LBX2	MA0699.1	3.15e-05	0.0271
MA0629.1	Rhox11	MA0629.1	3.35e-05	0.0289
MA0879.2	DLX1	MA0879.2	3.57e-05	0.0307
MA0114.4	HNF4A	MA0114.4	3.58e-05	0.0308
MA0613.1	FOXG1	MA0613.1	3.85e-05	0.0331
MA0871.2	TFEC	MA0871.2	4.22e-05	0.0364
MA1994.1 (Nkx2-1)	STREME-11	11-SCACTTGA	5.27e-91	0.0368
MA0693.3	Vdr	MA0693.3	4.42e-05	0.0381
MA0683.1 (POU4F2)	STREME-12	12-TATGCA	4.59e-51	0.0405
13-CTGTAAG	STREME-13	13-CTGTAAG	4.07e-30	0.0425
MA1117.1	RELB	MA1117.1	5.58e-05	0.0481
MA1108.2 (MXI1)	STREME-14	14-ATGTGGT	1.43e-47	0.0537
15-ATAGCTG	STREME-15	15-ATAGCTG	1.52e-35	0.0634
16-TATCAG	STREME-16	16-TATCAG	6.58e-66	0.0657
MA0597.2 (THAP1)	STREME-17	17-CAGGGC	2.77e-30	0.0865

### selecting just the list of names and checking for expression

All enriched motifs found

This area was for all motifs found in Xstreme analysis using NR peaks as background. #### EAR ##### EAR_open

mrc_palette <- c(
    "EAR_open" = "#F8766D",
    "EAR_close" = "#f6483c",
    "ESR_open" = "#7CAE00",
    "ESR_close" = "#587b00",
     "ESR_OC" = "#6a9500",
     "LR_open" = "#00BFC4",
     "LR_close" = "#008d91",
     "NR" = "#C77CFF"
  )

spec_dataframe <-
EAR_open_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_EAR_open %>%
                  dplyr::rename("SEA_PVALUE"=PVALUE) %>%
                  dplyr::select(RANK,ID:SEA_PVALUE)),
            by= c("RANK"="RANK", "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS",  "ID"="ID", "SEA_PVALUE"="SEA_PVALUE")) %>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="EAR_open") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name))) %>% 
# errat_EARo <-
  rbind(EAR_close_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_EAR_close %>%
                  dplyr::rename("SEA_PVALUE"=PVALUE) %>%
                  dplyr::select(RANK,ID:SEA_PVALUE)),
            by= c("RANK"="RANK", "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS",  "ID"="ID", "SEA_PVALUE"="SEA_PVALUE")) %>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="EAR_close") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name)))) %>%
# errat_EARo <-
    rbind(ESR_open_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_ESR_open %>%
                  dplyr::rename("SEA_PVALUE"=PVALUE) %>%
                  dplyr::select(RANK,ID:SEA_PVALUE)),
            by= c("RANK"="RANK", "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS",  "ID"="ID", "SEA_PVALUE"="SEA_PVALUE")) %>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="ESR_open") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name)))) %>%
# errat_EARo <-
    rbind(ESR_close_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_ESR_close %>%
                  dplyr::rename("SEA_PVALUE"=PVALUE) %>%
                  dplyr::select(RANK,ID:SEA_PVALUE)),
            by= c("RANK"="RANK", "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS",  "ID"="ID", "SEA_PVALUE"="SEA_PVALUE")) %>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="ESR_close") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name)))) %>%
# errat_EARo <-
  rbind(ESR_OC_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_ESR_OC %>%
                  dplyr::rename("SEA_PVALUE"=PVALUE) %>%
                  dplyr::select(RANK,ID:SEA_PVALUE)),
            by= c("RANK"="RANK", "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS",  "ID"="ID", "SEA_PVALUE"="SEA_PVALUE")) %>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="ESR_OC") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name)))) %>%
###rbind break#####
  rbind(LR_open_xstreme%>%
          dplyr::select(SEED_MOTIF:MOTIF_URL) %>% 
          dplyr::select(!"SEA_PVALUE") %>% 
          rownames_to_column("RANK") %>% 
          mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_LR_open %>%
                  dplyr::rename("SEA_PVALUE"=PVALUE) %>%
                  dplyr::select(RANK,ID:SEA_PVALUE)),
            by= c("RANK"="RANK","ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS",  "ID"="ID")) %>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="LR_open") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name)))) %>% 
### rbind break
  rbind(LR_close_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_LR_close %>%
                  dplyr::rename("SEA_PVALUE"=PVALUE) %>%
                  dplyr::select(RANK,ID:SEA_PVALUE)),
            by= c("RANK"="RANK", "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS",  "ID"="ID", "SEA_PVALUE"="SEA_PVALUE")) %>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="LR_close") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name)))) 
###plotting 
spec_dataframe %>% 
 ggplot(.,aes(x=mrc,y=ENR_RATIO,fill=mrc))+
  geom_boxplot()+ 
  theme_classic()+
  ylab("Enrichment ratio")+
  ggtitle("Enrichment ratio values across MRC")+
  scale_fill_manual(values=mrc_palette)

spec_dataframe %>% 
  ggplot(., aes(x=ENR_RATIO, fill = mrc))+
  geom_density(aes(alpha=0.4)) +
  theme_classic()+
  xlab("Enrichment ratio")+
  ggtitle("Enrichment ratio histogram MRC")+
  scale_fill_manual(values=mrc_palette)+
  coord_cartesian(xlim=c(1,5))

spec_dataframe %>% 
  # dplyr::filter(mrc=="LR_open") %>% 
  ggplot(., aes(x=mrc, y=-log(base=10,EVALUE), color=mrc))+
    geom_jitter()+
  theme_classic()+
  ylab(expression("-log[10] Evalue"))+
  ggtitle("Significant values across MRC motifs")+
  scale_color_manual(values=mrc_palette)

The enrichment ratio plot let me know where (sort of) to cut the plots to find the highest enrichment ratios by MRC. I am going to use 1.75 for most of them for now.

ER_rat <- 1.5
mrc_type <- "EAR_open"
spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="ELK3",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="ZNF93",paste(motif_name, RANK, sep="_"), if_else(motif_name=="Nrf1",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat))

spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>1.4) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="ELK3",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="ZNF93",paste(motif_name, RANK, sep="_"), if_else(motif_name=="Nrf1",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`/2.5), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~.*2.5,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat," merged clusters"))

EAR_close

ER_rat <- 1.5
mrc_type <- "EAR_close"
spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="MEIS1",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="ZNF384",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZNF257",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat))

spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>1.4) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="MEIS1",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="ZNF384",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZNF257",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`/2.5), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~.*2.5,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
   ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat," merged clusters"))

ESR

ESR_open

ER_rat <- 1.5
mrc_type <- "ESR_open"
spec_dataframe %>% 
  dplyr::filter(mrc=="ESR_open") %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^ZN*",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZSCAN4",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette["ESR_open"]) +
  geom_point(aes(x=`TP%`*4), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
   ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat))

spec_dataframe %>% 
  dplyr::filter(mrc=="ESR_open") %>% 
  dplyr::filter(ENR_RATIO>1.4) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^ZN*",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZSCAN4",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette["ESR_open"]) +
   geom_point(aes(x=`TP%`*4), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat," merged motif clusters"))

ESR_close

ER_rat <- 1.25
mrc_type <- "ESR_close"
spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^ZN*",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZSCAN4",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*4), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
 ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat))

spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>1.4) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^ZN*",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZSCAN4",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`*4), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat," merged motif clusters"))

ESR_OC

ER_rat <- 2
mrc_type <- "ESR_OC"
spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^Z*",paste(motif_name, RANK, sep="_"), if_else(motif_name=="FOSL2::JUNB",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*4), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
 ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat))

spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>1.4) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^Z*",paste(motif_name, RANK, sep="_"), if_else(motif_name=="FOSL2::JUNB",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`*4), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat," merged motif clusters"))

LR

LR_open

ER_rat <- 1
mrc_type <- "LR_open"
spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^R*",paste(motif_name,RANK, sep="_"), if_else(motif_name=="PKNOX2",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*4), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
 ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat))

spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^R*",paste(motif_name, RANK, sep="_"), if_else(motif_name=="PKNOX2",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`*4), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat," merged motif clusters"))

# spec_dataframe %>% 
#   dplyr::filter(mrc==mrc_type) %>% 
#   dplyr::filter(ENR_RATIO>ER_rat) #%>% 
#   dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)

LR_open_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  left_join(., sea_LR_open, by= c("ALT_ID"="ALT_ID","CONSENSUS"="CONSENSUS", "ID"="ID"))%>%
  # dplyr::filter(ENR_RATIO>1.25) %>% 
  dplyr::select(RANK.y,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%')%>%
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="LR_open") %>% 
 mutate(motif_name=if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),
                            ALT_ID,                          if_else(is.na(motif_name),ID,                            if_else(motif_name=="Rarb",paste(motif_name, RANK.y, sep="_"),                                 if_else(motif_name=="PKNOX2",paste(motif_name, RANK.y, sep="_"),motif_name)))))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette["LR_open"]) +
  geom_point(aes(x=`TP%`*4), size =4)+
  scale_x_continuous(expand=c (0,.5),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle("Late response open peaks")

LR_open_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  left_join(., sea_LR_open, by= c("ALT_ID"="ALT_ID","CONSENSUS"="CONSENSUS", "ID"="ID")) %>%
  # dplyr::filter(ENR_RATIO>1.25) %>% 
  dplyr::select(RANK.y,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%')%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  arrange(.,EVALUE.x) %>%
 # dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3))))#%>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="LR_open") %>% 
   # mutate(RowGroup=cumsum(ALT_ID != 0)) %>% 
mutate(motif_name=if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),
                            ALT_ID,                          if_else(is.na(motif_name),ID,  if_else(motif_name=="FOSL2::JUNB",paste(motif_name, RANK.y, sep="_"),                                  if_else(motif_name=="ZNF460",paste(motif_name, RANK.y, sep="_"),motif_name)))))%>%
ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette["LR_open"]) +
   geom_point(aes(x=`TP%`*4), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,1),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle("Late response open peaks")

LR_close

LR_close_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  left_join(., sea_LR_close, by= c("RANK"="RANK","ALT_ID"="ALT_ID","CONSENSUS"="CONSENSUS", "ID"="ID"))%>%
  dplyr::filter(ENR_RATIO>1.25) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%')%>%
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="LR_close") %>% 
  mutate(motif_name=if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),
                            ALT_ID,                          if_else(is.na(motif_name),ID,                         if_else(motif_name=="Rarb",paste(motif_name, RANK, sep="_"),                                 if_else(motif_name=="PKNOX2",paste(motif_name, RANK, sep="_"),motif_name)))))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette["LR_close"]) +
  geom_point(aes(x=`TP%`*4), size =4)+
  scale_x_continuous(expand=c (0,.5),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle("Late response close peaks")

LR_close_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  left_join(., sea_LR_close, by= c("RANK"="RANK","ALT_ID"="ALT_ID","CONSENSUS"="CONSENSUS", "ID"="ID")) %>%
  dplyr::filter(ENR_RATIO>1.25) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%')%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  arrange(.,EVALUE.x) %>%
 # dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3))))#%>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="LR_close") %>% 
   # mutate(RowGroup=cumsum(ALT_ID != 0)) %>% 
  mutate(motif_name=if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),
                            ALT_ID,
                            if_else(is.na(motif_name),ID, if_else(motif_name =="FOSL2::JUNB",paste(motif_name, RANK, sep="_"),                                  if_else(motif_name =="ZNF460",paste(motif_name, RANK, sep="_"),motif_name)))))%>%
ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette["LR_close"]) +
   geom_point(aes(x=`TP%`*4), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,1),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle("Late response close peaks")

motif and peak section (incomplete)

NR_gr <- import("data/Final_four_data/meme_bed/NR_df.bed")
EAR_open_gr <- import("data/Final_four_data/meme_bed/EAR_open.bed")
EAR_close_gr <- import("data/Final_four_data/meme_bed/EAR_close.bed")
ESR_open_gr <- import("data/Final_four_data/meme_bed/ESR_open.bed")
ESR_OC_gr <- import("data/Final_four_data/meme_bed/ESR_OC.bed")
ESR_close_gr <- import("data/Final_four_data/meme_bed/ESR_close.bed")
LR_open_gr <- import("data/Final_four_data/meme_bed/LR_open.bed")
LR_close_gr <- import("data/Final_four_data/meme_bed/LR_close.bed")


EAR_open_resized <- resize(EAR_open_gr, width = 1000,fix='center')
ESR_open_resized <- resize(ESR_open_gr, width = 1000,fix='center')
LR_open_resized <- resize(LR_open_gr, width = 1000,fix='center')
NR_resized <- resize(NR_gr, width = 1000,fix='center')

EAR_close_resized <- resize(EAR_close_gr, width = 1000,fix='center')
ESR_close_resized <- resize(ESR_close_gr, width = 1000,fix='center')
LR_close_resized <- resize(LR_close_gr, width = 1000,fix='center')
ESR_OC_resized <- resize(ESR_OC_gr, width = 1000,fix='center')



BiocManager::install('PWMEnrich')

seq_list <- list(EAR_open_resized=EAR_open_resized,EAR_close_resized=EAR_close_resized,ESR_open_resized=ESR_open_resized,ESR_close_resized=ESR_close_resized,ESR_OC_resized=ESR_OC_resized,LR_open_resized=LR_open_resized,LR_close_resized=LR_close_resized,NR_resized=NR_resized)



# seq_all <- lapply(seq_list, getSeq, x=BSgenome.Hsapiens.UCSC.hg38)
# saveRDS(seq_all, "data/Final_four_data/sequencing_R_object8_motif.RDS")
seq_all <- readRDS("data/Final_four_data/sequencing_R_object8_motif.RDS")

NRF1

# 
# motifs_NRF1 = query(query(MotifDb, 'Hsapiens'), 'NRF1')
#     NRF1_motif <- motifs_NRF1$`Hsapiens-jaspar2018-NRF1-MA0506.1`
# #
# #
# NRF1_pwm = PWMatrix(
#     ID = 'NRF1',
#     profileMatrix = NRF1_motif)
# 
# list_nrf1 = lapply(unlist(seq_all) , FUN=searchSeq, x=NRF1_pwm, min.score="80%", strand="*")
# 
# nrf1storage <- map_dfr(list_nrf1, ~as.data.frame(.x), .id="id")

# saveRDS(nrf1storage, "data/Final_four_data/nrf1_motif_8group.RDS")
nrf1_motif_8group <- readRDS("data/Final_four_data/nrf1_motif_8group.RDS")
nrf1_motif_8group %>%
  mutate(id= gsub("_resized","",id)) %>% 
  # dplyr::filter(id =="EAR_open"|id == "NR"|id=="EAR_close") %>% 
  mutate(position=start-500) %>% 
  ggplot(.,aes(position, color = id))+
  geom_density(trim = FALSE,size=1.5) +
  theme_bw() +
  scale_color_manual(values=mrc_palette)

BACH2

ZNF384

enriched in EAR, ESR, LR

# motifs_ZNF384 = query(query(MotifDb, 'Hsapiens'), 'ZNF384')
# ZNF384_motif <- motifs_ZNF384$`Hsapiens-jaspar2022-ZNF384-MA1125.1`
# #
# #
# ZNF384_pwm = PWMatrix(
#     ID = 'ZNF384',
#     profileMatrix = ZNF384_motif)
# znf384_test = lapply(unlist(seq_all) , FUN=searchSeq, x=BACH2_pwm, min.score="80%", strand="*")
# 
# storage <- lapply(list_test, relScore)
# str(storage)
# storage %>% 
#   map(as_tibble) %>% 
#   reduce(bind_rows)
# znf384_storage <- map_dfr(znf384_test, ~as.data.frame(.x), .id="id")

# saveRDS(znf384_storage, "data/Final_four_data/znf384_motif_8group.RDS")
znf384_motif_8group <- readRDS("data/Final_four_data/znf384_motif_8group.RDS")
znf384_motif_8group %>%
  mutate(id= gsub("_resized","",id)) %>% 
  # dplyr::filter(id =="EAR_open"|id == "NR"|id=="EAR_close") %>% 
  # dplyr::filter(relScore>0.9) %>% 
  mutate(position=start-500) %>% 
  ggplot(.,aes(position, color = id))+
  geom_density(trim = FALSE,size=1.5) +
  theme_bw() +
  scale_color_manual(values=mrc_palette)+
  ggtitle("ZNF384 motif")

Session information

sessionInfo()

R version 4.4.1 (2024-06-14 ucrt)
Platform: x86_64-w64-mingw32/x64
Running under: Windows 10 x64 (build 19045)

Matrix products: default


locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

time zone: America/Chicago
tzcode source: internal

attached base packages:
[1] grid      stats4    stats     graphics  grDevices utils     datasets 
[8] methods   base     

other attached packages:
 [1] BSgenome.Hsapiens.UCSC.hg38_1.4.5       
 [2] BSgenome_1.72.0                         
 [3] BiocIO_1.14.0                           
 [4] MotifDb_1.46.0                          
 [5] Biostrings_2.72.1                       
 [6] XVector_0.44.0                          
 [7] TFBSTools_1.42.0                        
 [8] JASPAR2022_0.99.8                       
 [9] BiocFileCache_2.12.0                    
[10] dbplyr_2.5.0                            
[11] devtools_2.4.5                          
[12] usethis_3.0.0                           
[13] ggpubr_0.6.0                            
[14] BiocParallel_1.38.0                     
[15] Cormotif_1.50.0                         
[16] affy_1.82.0                             
[17] scales_1.3.0                            
[18] VennDiagram_1.7.3                       
[19] futile.logger_1.4.3                     
[20] gridExtra_2.3                           
[21] ggfortify_0.4.17                        
[22] edgeR_4.2.1                             
[23] limma_3.60.4                            
[24] rtracklayer_1.64.0                      
[25] org.Hs.eg.db_3.19.1                     
[26] TxDb.Hsapiens.UCSC.hg38.knownGene_3.18.0
[27] GenomicFeatures_1.56.0                  
[28] AnnotationDbi_1.66.0                    
[29] Biobase_2.64.0                          
[30] GenomicRanges_1.56.1                    
[31] GenomeInfoDb_1.40.1                     
[32] IRanges_2.38.1                          
[33] S4Vectors_0.42.1                        
[34] BiocGenerics_0.50.0                     
[35] ChIPseeker_1.40.0                       
[36] RColorBrewer_1.1-3                      
[37] broom_1.0.6                             
[38] kableExtra_1.4.0                        
[39] lubridate_1.9.3                         
[40] forcats_1.0.0                           
[41] stringr_1.5.1                           
[42] dplyr_1.1.4                             
[43] purrr_1.0.2                             
[44] readr_2.1.5                             
[45] tidyr_1.3.1                             
[46] tibble_3.2.1                            
[47] ggplot2_3.5.1                           
[48] tidyverse_2.0.0                         
[49] workflowr_1.7.1                         

loaded via a namespace (and not attached):
  [1] fs_1.6.4                               
  [2] matrixStats_1.4.1                      
  [3] bitops_1.0-8                           
  [4] DirichletMultinomial_1.46.0            
  [5] enrichplot_1.24.4                      
  [6] httr_1.4.7                             
  [7] profvis_0.3.8                          
  [8] tools_4.4.1                            
  [9] backports_1.5.0                        
 [10] utf8_1.2.4                             
 [11] R6_2.5.1                               
 [12] lazyeval_0.2.2                         
 [13] urlchecker_1.0.1                       
 [14] withr_3.0.1                            
 [15] preprocessCore_1.66.0                  
 [16] cli_3.6.3                              
 [17] formatR_1.14                           
 [18] scatterpie_0.2.4                       
 [19] labeling_0.4.3                         
 [20] sass_0.4.9                             
 [21] Rsamtools_2.20.0                       
 [22] systemfonts_1.1.0                      
 [23] yulab.utils_0.1.7                      
 [24] DOSE_3.30.5                            
 [25] svglite_2.1.3                          
 [26] R.utils_2.12.3                         
 [27] sessioninfo_1.2.2                      
 [28] plotrix_3.8-4                          
 [29] rstudioapi_0.16.0                      
 [30] RSQLite_2.3.7                          
 [31] generics_0.1.3                         
 [32] gridGraphics_0.5-1                     
 [33] TxDb.Hsapiens.UCSC.hg19.knownGene_3.2.2
 [34] gtools_3.9.5                           
 [35] car_3.1-2                              
 [36] GO.db_3.19.1                           
 [37] Matrix_1.7-0                           
 [38] fansi_1.0.6                            
 [39] abind_1.4-8                            
 [40] R.methodsS3_1.8.2                      
 [41] lifecycle_1.0.4                        
 [42] whisker_0.4.1                          
 [43] yaml_2.3.10                            
 [44] carData_3.0-5                          
 [45] SummarizedExperiment_1.34.0            
 [46] gplots_3.1.3.1                         
 [47] qvalue_2.36.0                          
 [48] SparseArray_1.4.8                      
 [49] blob_1.2.4                             
 [50] promises_1.3.0                         
 [51] pwalign_1.0.0                          
 [52] crayon_1.5.3                           
 [53] miniUI_0.1.1.1                         
 [54] lattice_0.22-6                         
 [55] cowplot_1.1.3                          
 [56] annotate_1.82.0                        
 [57] KEGGREST_1.44.1                        
 [58] pillar_1.9.0                           
 [59] knitr_1.48                             
 [60] fgsea_1.30.0                           
 [61] rjson_0.2.23                           
 [62] boot_1.3-31                            
 [63] codetools_0.2-20                       
 [64] fastmatch_1.1-4                        
 [65] glue_1.7.0                             
 [66] getPass_0.2-4                          
 [67] ggfun_0.1.6                            
 [68] remotes_2.5.0                          
 [69] data.table_1.16.0                      
 [70] vctrs_0.6.5                            
 [71] png_0.1-8                              
 [72] treeio_1.28.0                          
 [73] poweRlaw_0.80.0                        
 [74] gtable_0.3.5                           
 [75] cachem_1.1.0                           
 [76] xfun_0.47                              
 [77] mime_0.12                              
 [78] S4Arrays_1.4.1                         
 [79] tidygraph_1.3.1                        
 [80] pracma_2.4.4                           
 [81] statmod_1.5.0                          
 [82] ellipsis_0.3.2                         
 [83] nlme_3.1-166                           
 [84] ggtree_3.12.0                          
 [85] bit64_4.0.5                            
 [86] filelock_1.0.3                         
 [87] rprojroot_2.0.4                        
 [88] bslib_0.8.0                            
 [89] affyio_1.74.0                          
 [90] KernSmooth_2.23-24                     
 [91] splitstackshape_1.4.8                  
 [92] seqLogo_1.70.0                         
 [93] colorspace_2.1-1                       
 [94] DBI_1.2.3                              
 [95] tidyselect_1.2.1                       
 [96] processx_3.8.4                         
 [97] bit_4.0.5                              
 [98] compiler_4.4.1                         
 [99] curl_5.2.2                             
[100] git2r_0.33.0                           
[101] httr2_1.0.4                            
[102] xml2_1.3.6                             
[103] DelayedArray_0.30.1                    
[104] shadowtext_0.1.4                       
[105] caTools_1.18.3                         
[106] callr_3.7.6                            
[107] rappdirs_0.3.3                         
[108] digest_0.6.37                          
[109] rmarkdown_2.28                         
[110] htmltools_0.5.8.1                      
[111] pkgconfig_2.0.3                        
[112] MatrixGenerics_1.16.0                  
[113] highr_0.11                             
[114] fastmap_1.2.0                          
[115] htmlwidgets_1.6.4                      
[116] rlang_1.1.4                            
[117] UCSC.utils_1.0.0                       
[118] shiny_1.9.1                            
[119] farver_2.1.2                           
[120] jquerylib_0.1.4                        
[121] jsonlite_1.8.8                         
[122] GOSemSim_2.30.2                        
[123] R.oo_1.26.0                            
[124] RCurl_1.98-1.16                        
[125] magrittr_2.0.3                         
[126] GenomeInfoDbData_1.2.12                
[127] ggplotify_0.1.2                        
[128] patchwork_1.3.0                        
[129] munsell_0.5.1                          
[130] Rcpp_1.0.13                            
[131] ape_5.8                                
[132] viridis_0.6.5                          
[133] stringi_1.8.4                          
[134] ggraph_2.2.1                           
[135] zlibbioc_1.50.0                        
[136] MASS_7.3-61                            
[137] pkgbuild_1.4.4                         
[138] plyr_1.8.9                             
[139] parallel_4.4.1                         
[140] ggrepel_0.9.6                          
[141] CNEr_1.40.0                            
[142] graphlayouts_1.1.1                     
[143] splines_4.4.1                          
[144] hms_1.1.3                              
[145] locfit_1.5-9.10                        
[146] ps_1.8.0                               
[147] igraph_2.0.3                           
[148] ggsignif_0.6.4                         
[149] pkgload_1.4.0                          
[150] reshape2_1.4.4                         
[151] TFMPvalue_0.0.9                        
[152] futile.options_1.0.1                   
[153] XML_3.99-0.17                          
[154] evaluate_1.0.0                         
[155] lambda.r_1.2.4                         
[156] BiocManager_1.30.25                    
[157] tzdb_0.4.0                             
[158] tweenr_2.0.3                           
[159] httpuv_1.6.15                          
[160] polyclip_1.10-7                        
[161] ggforce_0.4.2                          
[162] xtable_1.8-4                           
[163] restfulr_0.0.15                        
[164] tidytree_0.4.6                         
[165] rstatix_0.7.2                          
[166] later_1.3.2                            
[167] viridisLite_0.4.2                      
[168] aplot_0.2.3                            
[169] memoise_2.0.1                          
[170] GenomicAlignments_1.40.0               
[171] timechange_0.3.0