Last updated: 2023-04-17

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Knit directory: Cardiotoxicity/

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GO Analysis

I have created several files from the RNA analysis that contain the significant genes(determined by adj.P.val < 0.1) from each Time and Condition. The names of the files are in the following format: ‘sigV’+Drug(2 letters)+time.

example: ‘sigVDA3.txt’ means this file contains the significant DE genes from the Daunorubicin 3 hour compared to Vehicle Control 3 hour analysis

The analysis is based on all genes that passed the rowMeans>0 from the previous page whicha are about 14084 genes expressed in my RNA-seq data link

Below is the analysis of differentially expressed genes for each treatment at 3 hours and 24 hours.


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## Daunorubicin

This is analysis on the significantly differentially expressed genes for Daunorubicin by 3 and 24 hours.

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	274	1915	2.18e-33
GO:BP	GO:0006366	transcription by RNA polymerase II	280	1991	2.73e-33
GO:BP	GO:0006351	DNA-templated transcription	278	2683	1.90e-29
GO:BP	GO:0097659	nucleic acid-templated transcription	278	2684	1.90e-29
GO:BP	GO:1903506	regulation of nucleic acid-templated transcription	271	2581	4.28e-29
GO:BP	GO:0006355	regulation of DNA-templated transcription	271	2579	4.28e-29
GO:BP	GO:0051252	regulation of RNA metabolic process	286	2849	6.20e-29
GO:BP	GO:0032774	RNA biosynthetic process	278	2714	6.38e-29
GO:BP	GO:2001141	regulation of RNA biosynthetic process	271	2598	9.41e-29
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	298	3105	9.08e-28
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	286	3015	2.40e-25
GO:BP	GO:0031326	regulation of cellular biosynthetic process	287	3123	9.71e-23
GO:BP	GO:0009889	regulation of biosynthetic process	288	3174	5.86e-22
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	282	3083	8.49e-22
GO:BP	GO:0018130	heterocycle biosynthetic process	284	3148	3.40e-21
GO:BP	GO:0019438	aromatic compound biosynthetic process	283	3149	1.20e-20
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	286	3253	2.77e-19
GO:BP	GO:0009059	macromolecule biosynthetic process	306	3730	3.81e-18
GO:BP	GO:0031323	regulation of cellular metabolic process	337	4305	1.90e-16
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	300	3758	3.73e-15
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	333	4330	3.20e-14
GO:BP	GO:0080090	regulation of primary metabolic process	339	4440	4.87e-14
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	92	735	3.73e-12
GO:BP	GO:0044249	cellular biosynthetic process	326	4465	2.43e-11
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	102	1009	1.21e-10
GO:BP	GO:1903507	negative regulation of nucleic acid-templated transcription	102	1011	1.28e-10
GO:BP	GO:1901576	organic substance biosynthetic process	327	4537	1.38e-10
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	102	1020	2.29e-10
GO:BP	GO:0051253	negative regulation of RNA metabolic process	107	1115	4.24e-10
GO:BP	GO:0009058	biosynthetic process	328	4595	6.33e-10
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	110	1215	6.62e-09
GO:BP	GO:0010468	regulation of gene expression	303	3583	9.50e-09
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	108	1206	1.01e-08
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	147	1304	1.77e-08
GO:BP	GO:1903508	positive regulation of nucleic acid-templated transcription	147	1304	1.77e-08
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	147	1311	2.32e-08
GO:BP	GO:0051254	positive regulation of RNA metabolic process	155	1431	3.18e-08
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	108	1249	8.18e-08
GO:BP	GO:0009890	negative regulation of biosynthetic process	108	1273	2.41e-07
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	112	925	3.68e-07
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	154	1499	1.50e-06
GO:BP	GO:0031324	negative regulation of cellular metabolic process	141	1780	1.72e-06
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	161	1600	1.81e-06
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	157	1571	9.83e-06
GO:BP	GO:0009891	positive regulation of biosynthetic process	157	1598	3.41e-05
GO:BP	GO:0060255	regulation of macromolecule metabolic process	342	4640	5.02e-05
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	131	1866	3.74e-04
GO:BP	GO:0019222	regulation of metabolic process	135	5039	7.06e-04
GO:BP	GO:0031325	positive regulation of cellular metabolic process	168	2373	1.46e-03
GO:BP	GO:0060411	cardiac septum morphogenesis	8	67	1.76e-03
GO:BP	GO:0002763	positive regulation of myeloid leukocyte differentiation	2	34	1.95e-03
GO:BP	GO:0140467	integrated stress response signaling	7	34	1.95e-03
GO:BP	GO:0003281	ventricular septum development	11	69	2.55e-03
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	169	2425	2.55e-03
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	23	229	3.40e-03
GO:BP	GO:0003181	atrioventricular valve morphogenesis	5	24	3.40e-03
GO:BP	GO:0030510	regulation of BMP signaling pathway	5	84	3.99e-03
GO:BP	GO:0043009	chordate embryonic development	47	531	4.25e-03
GO:BP	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	15	126	4.42e-03
GO:BP	GO:0045639	positive regulation of myeloid cell differentiation	2	67	5.06e-03
GO:BP	GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	15	127	5.49e-03
GO:BP	GO:0003162	atrioventricular node development	3	8	5.49e-03
GO:BP	GO:0003171	atrioventricular valve development	5	26	5.52e-03
GO:BP	GO:0018076	N-terminal peptidyl-lysine acetylation	3	4	6.40e-03
GO:BP	GO:0021915	neural tube development	16	146	6.40e-03
GO:BP	GO:0002761	regulation of myeloid leukocyte differentiation	2	77	6.74e-03
GO:BP	GO:0003007	heart morphogenesis	28	212	7.56e-03
GO:BP	GO:0009792	embryo development ending in birth or egg hatching	47	548	7.91e-03
GO:BP	GO:0019827	stem cell population maintenance	14	150	9.62e-03
GO:BP	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	12	99	9.97e-03
GO:BP	GO:0016070	RNA metabolic process	42	3593	1.00e-02
GO:BP	GO:0090304	nucleic acid metabolic process	44	4047	1.00e-02
GO:BP	GO:0060840	artery development	11	82	1.05e-02
GO:BP	GO:0045643	regulation of eosinophil differentiation	1	1	1.09e-02
GO:BP	GO:0045659	negative regulation of neutrophil differentiation	1	2	1.09e-02
GO:BP	GO:0098727	maintenance of cell number	14	152	1.09e-02
GO:BP	GO:0045645	positive regulation of eosinophil differentiation	1	1	1.09e-02
GO:BP	GO:0030853	negative regulation of granulocyte differentiation	2	6	1.22e-02
GO:BP	GO:1903708	positive regulation of hemopoiesis	2	118	1.29e-02
GO:BP	GO:1902107	positive regulation of leukocyte differentiation	2	118	1.29e-02
GO:BP	GO:0003279	cardiac septum development	12	101	1.39e-02
GO:BP	GO:0045658	regulation of neutrophil differentiation	1	2	1.52e-02
GO:BP	GO:0090425	acinar cell differentiation	3	5	1.56e-02
GO:BP	GO:0003215	cardiac right ventricle morphogenesis	6	17	1.56e-02
GO:BP	GO:0045637	regulation of myeloid cell differentiation	2	151	1.58e-02
GO:BP	GO:0003179	heart valve morphogenesis	6	50	1.58e-02
GO:BP	GO:0045597	positive regulation of cell differentiation	3	619	1.59e-02
GO:BP	GO:0002573	myeloid leukocyte differentiation	2	145	1.66e-02
GO:BP	GO:0001841	neural tube formation	11	101	1.71e-02
GO:BP	GO:0010944	negative regulation of transcription by competitive promoter binding	2	8	1.78e-02
GO:BP	GO:0030509	BMP signaling pathway	5	123	1.78e-02
GO:BP	GO:0055025	positive regulation of cardiac muscle tissue development	1	2	1.80e-02
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	8	79	1.80e-02
GO:BP	GO:0051890	regulation of cardioblast differentiation	4	7	1.84e-02
GO:BP	GO:0071772	response to BMP	11	131	1.89e-02
GO:BP	GO:0071773	cellular response to BMP stimulus	11	131	1.89e-02
GO:BP	GO:0003183	mitral valve morphogenesis	3	10	1.89e-02
GO:BP	GO:0060412	ventricular septum morphogenesis	7	40	1.93e-02
GO:BP	GO:1902893	regulation of miRNA transcription	5	51	1.96e-02
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	179	2648	1.96e-02
GO:BP	GO:0030222	eosinophil differentiation	1	2	2.05e-02
GO:BP	GO:0061614	miRNA transcription	5	52	2.05e-02
GO:BP	GO:0007179	transforming growth factor beta receptor signaling pathway	17	177	2.18e-02
GO:BP	GO:0002320	lymphoid progenitor cell differentiation	5	17	2.31e-02
GO:BP	GO:0060430	lung saccule development	2	7	2.31e-02
GO:BP	GO:0003174	mitral valve development	3	11	2.31e-02
GO:BP	GO:0048636	positive regulation of muscle organ development	1	3	2.31e-02
GO:BP	GO:0045844	positive regulation of striated muscle tissue development	1	3	2.31e-02
GO:BP	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	2	12	2.43e-02
GO:BP	GO:0036499	PERK-mediated unfolded protein response	4	17	2.43e-02
GO:BP	GO:0010660	regulation of muscle cell apoptotic process	8	57	2.45e-02
GO:BP	GO:0001657	ureteric bud development	4	75	2.48e-02
GO:BP	GO:0006473	protein acetylation	16	208	2.48e-02
GO:BP	GO:0072164	mesonephric tubule development	4	76	2.51e-02
GO:BP	GO:0072163	mesonephric epithelium development	4	76	2.51e-02
GO:BP	GO:0030514	negative regulation of BMP signaling pathway	3	45	2.52e-02
GO:BP	GO:1902105	regulation of leukocyte differentiation	2	197	2.61e-02
GO:BP	GO:0003310	pancreatic A cell differentiation	2	2	2.74e-02
GO:BP	GO:0001823	mesonephros development	4	77	2.74e-02
GO:BP	GO:0030854	positive regulation of granulocyte differentiation	1	5	2.74e-02
GO:BP	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	2	4	2.74e-02
GO:BP	GO:0014020	primary neural tube formation	10	94	2.74e-02
GO:BP	GO:0003170	heart valve development	6	57	2.75e-02
GO:BP	GO:0034616	response to laminar fluid shear stress	2	14	2.93e-02
GO:BP	GO:0003148	outflow tract septum morphogenesis	3	23	2.99e-02
GO:BP	GO:0030852	regulation of granulocyte differentiation	2	11	3.15e-02
GO:BP	GO:0055024	regulation of cardiac muscle tissue development	1	3	3.15e-02
GO:BP	GO:0030223	neutrophil differentiation	1	8	3.15e-02
GO:BP	GO:0007507	heart development	41	502	3.15e-02
GO:BP	GO:0010657	muscle cell apoptotic process	8	60	3.15e-02
GO:BP	GO:0030513	positive regulation of BMP signaling pathway	5	34	3.15e-02
GO:BP	GO:2000628	regulation of miRNA metabolic process	5	62	3.15e-02
GO:BP	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	6	22	3.15e-02
GO:BP	GO:0002328	pro-B cell differentiation	3	10	3.18e-02
GO:BP	GO:0010656	negative regulation of muscle cell apoptotic process	6	36	3.20e-02
GO:BP	GO:1904290	negative regulation of mitotic DNA damage checkpoint	1	1	3.37e-02
GO:BP	GO:0048844	artery morphogenesis	8	57	3.53e-02
GO:BP	GO:1902459	positive regulation of stem cell population maintenance	6	44	3.53e-02
GO:BP	GO:0003151	outflow tract morphogenesis	9	66	3.53e-02
GO:BP	GO:0072175	epithelial tube formation	12	127	3.53e-02
GO:BP	GO:0003206	cardiac chamber morphogenesis	8	109	3.53e-02
GO:BP	GO:1903706	regulation of hemopoiesis	2	277	3.53e-02
GO:BP	GO:0018394	peptidyl-lysine acetylation	14	180	3.53e-02
GO:BP	GO:0009250	glucan biosynthetic process	6	38	3.53e-02
GO:BP	GO:0030099	myeloid cell differentiation	2	301	3.53e-02
GO:BP	GO:0005978	glycogen biosynthetic process	6	38	3.53e-02
GO:BP	GO:0060419	heart growth	12	72	3.53e-02
GO:BP	GO:2000736	regulation of stem cell differentiation	12	74	3.53e-02
GO:BP	GO:0051094	positive regulation of developmental process	3	958	3.53e-02
GO:BP	GO:1900034	regulation of cellular response to heat	4	16	3.53e-02
GO:BP	GO:0001701	in utero embryonic development	29	342	3.59e-02
GO:BP	GO:0010720	positive regulation of cell development	2	316	3.77e-02
GO:BP	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	1	7	3.81e-02
GO:BP	GO:0071559	response to transforming growth factor beta	19	224	3.97e-02
GO:BP	GO:1903674	regulation of cap-dependent translational initiation	1	1	3.98e-02
GO:BP	GO:1903676	positive regulation of cap-dependent translational initiation	1	1	3.98e-02
GO:BP	GO:2000026	regulation of multicellular organismal development	3	1007	3.98e-02
GO:BP	GO:0015074	DNA integration	4	11	4.14e-02
GO:BP	GO:0045651	positive regulation of macrophage differentiation	1	12	4.14e-02
GO:BP	GO:0060509	type I pneumocyte differentiation	1	8	4.14e-02
GO:BP	GO:0055017	cardiac muscle tissue growth	11	65	4.14e-02
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	44	4503	4.14e-02
GO:BP	GO:0035910	ascending aorta morphogenesis	2	4	4.19e-02
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	22	301	4.27e-02
GO:BP	GO:0045622	regulation of T-helper cell differentiation	3	20	4.28e-02
GO:BP	GO:0001838	embryonic epithelial tube formation	11	116	4.42e-02
GO:BP	GO:2001020	regulation of response to DNA damage stimulus	25	292	4.50e-02
GO:BP	GO:2000320	negative regulation of T-helper 17 cell differentiation	2	6	4.57e-02
GO:BP	GO:0035904	aorta development	7	49	4.60e-02
GO:BP	GO:0010664	negative regulation of striated muscle cell apoptotic process	6	25	4.87e-02
GO:BP	GO:0060395	SMAD protein signal transduction	5	65	4.90e-02
GO:BP	GO:0001843	neural tube closure	9	90	4.91e-02
GO:BP	GO:0051170	import into nucleus	4	151	4.97e-02
GO:BP	GO:0045595	regulation of cell differentiation	3	1134	4.98e-02
KEGG	KEGG:05168	Herpes simplex virus 1 infection	86	415	6.56e-21

A look at the Daunorubicin specific genes at 3 hours and how they may relate to 24 hour genes using GO analysis

3 hours specifically:

`.cols` has been renamed and is deprecated, please use `.vars`

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	137	1915	6.69e-09
GO:BP	GO:0006366	transcription by RNA polymerase II	140	1991	6.69e-09
GO:BP	GO:0006351	DNA-templated transcription	160	2683	1.69e-08
GO:BP	GO:0097659	nucleic acid-templated transcription	160	2684	1.69e-08
GO:BP	GO:0006355	regulation of DNA-templated transcription	158	2579	2.30e-08
GO:BP	GO:1903506	regulation of nucleic acid-templated transcription	158	2581	2.30e-08
GO:BP	GO:0032774	RNA biosynthetic process	160	2714	2.30e-08
GO:BP	GO:2001141	regulation of RNA biosynthetic process	158	2598	3.32e-08
GO:BP	GO:0051252	regulation of RNA metabolic process	129	2849	3.56e-08
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	135	3105	9.46e-08
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	130	3015	3.83e-07
GO:BP	GO:0031326	regulation of cellular biosynthetic process	131	3123	2.55e-06
GO:BP	GO:0009889	regulation of biosynthetic process	131	3174	6.85e-06
GO:BP	GO:0018130	heterocycle biosynthetic process	129	3148	1.34e-05
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	127	3083	1.45e-05
GO:BP	GO:0019438	aromatic compound biosynthetic process	128	3149	2.72e-05
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	131	3253	3.16e-05
GO:BP	GO:0009059	macromolecule biosynthetic process	142	3730	4.15e-05
GO:BP	GO:0031323	regulation of cellular metabolic process	157	4305	2.47e-04
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	139	3758	5.77e-04
GO:BP	GO:0044249	cellular biosynthetic process	158	4465	7.01e-04
GO:BP	GO:0140467	integrated stress response signaling	5	34	1.09e-03
GO:BP	GO:1901576	organic substance biosynthetic process	159	4537	1.09e-03
GO:BP	GO:1903508	positive regulation of nucleic acid-templated transcription	83	1304	1.09e-03
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	83	1304	1.09e-03
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	83	1311	1.23e-03
GO:BP	GO:0009058	biosynthetic process	159	4595	2.52e-03
GO:BP	GO:0051254	positive regulation of RNA metabolic process	86	1431	3.44e-03
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	89	1499	3.69e-03
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	88	1571	5.40e-03
GO:BP	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	3	18	7.29e-03
GO:BP	GO:0080090	regulation of primary metabolic process	217	4440	1.03e-02
GO:BP	GO:0009891	positive regulation of biosynthetic process	88	1598	1.03e-02
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	61	925	1.37e-02
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	211	4330	1.51e-02
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	90	1600	1.65e-02
GO:BP	GO:2000121	regulation of removal of superoxide radicals	2	6	2.35e-02
GO:BP	GO:0036499	PERK-mediated unfolded protein response	3	17	2.40e-02
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	36	735	4.04e-02
GO:BP	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	3	39	4.65e-02
GO:BP	GO:0051253	negative regulation of RNA metabolic process	43	1115	4.89e-02
KEGG	KEGG:05168	Herpes simplex virus 1 infection	44	415	5.92e-08

`.cols` has been renamed and is deprecated, please use `.vars`

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	137	1915	6.69e-09
GO:BP	GO:0006366	transcription by RNA polymerase II	140	1991	6.69e-09
GO:BP	GO:0006351	DNA-templated transcription	160	2683	1.69e-08
GO:BP	GO:0097659	nucleic acid-templated transcription	160	2684	1.69e-08
GO:BP	GO:0006355	regulation of DNA-templated transcription	158	2579	2.30e-08
GO:BP	GO:1903506	regulation of nucleic acid-templated transcription	158	2581	2.30e-08
GO:BP	GO:0032774	RNA biosynthetic process	160	2714	2.30e-08
GO:BP	GO:2001141	regulation of RNA biosynthetic process	158	2598	3.32e-08
GO:BP	GO:0051252	regulation of RNA metabolic process	129	2849	3.56e-08
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	135	3105	9.46e-08
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	130	3015	3.83e-07
GO:BP	GO:0031326	regulation of cellular biosynthetic process	131	3123	2.55e-06
GO:BP	GO:0009889	regulation of biosynthetic process	131	3174	6.85e-06
GO:BP	GO:0018130	heterocycle biosynthetic process	129	3148	1.34e-05
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	127	3083	1.45e-05
GO:BP	GO:0019438	aromatic compound biosynthetic process	128	3149	2.72e-05
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	131	3253	3.16e-05
GO:BP	GO:0009059	macromolecule biosynthetic process	142	3730	4.15e-05
GO:BP	GO:0031323	regulation of cellular metabolic process	157	4305	2.47e-04
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	139	3758	5.77e-04
GO:BP	GO:0044249	cellular biosynthetic process	158	4465	7.01e-04
GO:BP	GO:0140467	integrated stress response signaling	5	34	1.09e-03
GO:BP	GO:1901576	organic substance biosynthetic process	159	4537	1.09e-03
GO:BP	GO:1903508	positive regulation of nucleic acid-templated transcription	83	1304	1.09e-03
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	83	1304	1.09e-03
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	83	1311	1.23e-03
GO:BP	GO:0009058	biosynthetic process	159	4595	2.52e-03
GO:BP	GO:0051254	positive regulation of RNA metabolic process	86	1431	3.44e-03
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	89	1499	3.69e-03
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	88	1571	5.40e-03
GO:BP	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	3	18	7.29e-03
GO:BP	GO:0080090	regulation of primary metabolic process	217	4440	1.03e-02
GO:BP	GO:0009891	positive regulation of biosynthetic process	88	1598	1.03e-02
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	61	925	1.37e-02
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	211	4330	1.51e-02
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	90	1600	1.65e-02
GO:BP	GO:2000121	regulation of removal of superoxide radicals	2	6	2.35e-02
GO:BP	GO:0036499	PERK-mediated unfolded protein response	3	17	2.40e-02
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	36	735	4.04e-02
GO:BP	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	3	39	4.65e-02
GO:BP	GO:0051253	negative regulation of RNA metabolic process	43	1115	4.89e-02
KEGG	KEGG:05168	Herpes simplex virus 1 infection	44	415	5.92e-08

[1] 455

###Daunorubicin 24 sigDEG

`.cols` has been renamed and is deprecated, please use `.vars`

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0000278	mitotic cell cycle	186	833	2.06e-06
GO:BP	GO:0000819	sister chromatid segregation	74	234	2.06e-06
GO:BP	GO:0000070	mitotic sister chromatid segregation	50	193	2.20e-06
GO:BP	GO:0007059	chromosome segregation	84	378	2.79e-06
GO:BP	GO:0051301	cell division	149	567	6.11e-06
GO:BP	GO:0140014	mitotic nuclear division	79	264	1.36e-05
GO:BP	GO:1903047	mitotic cell cycle process	155	700	1.36e-05
GO:BP	GO:0045930	negative regulation of mitotic cell cycle	77	208	1.63e-05
GO:BP	GO:0010564	regulation of cell cycle process	143	620	5.85e-05
GO:BP	GO:0006541	glutamine metabolic process	4	23	8.15e-05
KEGG	KEGG:04115	p53 signaling pathway	15	65	6.45e-06

###Daunorubicin 3 v 24 intersection

`.cols` has been renamed and is deprecated, please use `.vars`

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	148	1915	5.72e-18
GO:BP	GO:0006366	transcription by RNA polymerase II	149	1991	4.76e-17
GO:BP	GO:0006355	regulation of DNA-templated transcription	168	2579	4.45e-14
GO:BP	GO:1903506	regulation of nucleic acid-templated transcription	168	2581	4.45e-14
GO:BP	GO:2001141	regulation of RNA biosynthetic process	168	2598	7.02e-14
GO:BP	GO:0006351	DNA-templated transcription	170	2683	1.29e-13
GO:BP	GO:0097659	nucleic acid-templated transcription	170	2684	1.29e-13
GO:BP	GO:0032774	RNA biosynthetic process	170	2714	3.04e-13
GO:BP	GO:0051252	regulation of RNA metabolic process	175	2849	3.04e-13
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	175	3015	3.04e-11
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	179	3105	3.04e-11
GO:BP	GO:0031326	regulation of cellular biosynthetic process	176	3123	5.63e-10
GO:BP	GO:0009889	regulation of biosynthetic process	177	3174	1.11e-09
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	173	3083	1.42e-09
GO:BP	GO:0018130	heterocycle biosynthetic process	175	3148	1.74e-09
GO:BP	GO:0019438	aromatic compound biosynthetic process	174	3149	4.35e-09
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	79	3253	9.96e-09
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	57	735	1.20e-08
GO:BP	GO:0009059	macromolecule biosynthetic process	168	3730	3.58e-07
GO:BP	GO:0031323	regulation of cellular metabolic process	89	4305	1.20e-06
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	80	3758	2.41e-06
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	62	1009	3.49e-06
GO:BP	GO:1903507	negative regulation of nucleic acid-templated transcription	62	1011	3.53e-06
GO:BP	GO:0080090	regulation of primary metabolic process	91	4440	3.99e-06
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	36	4330	4.40e-06
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	62	1020	4.65e-06
GO:BP	GO:0051253	negative regulation of RNA metabolic process	66	1115	8.05e-06
GO:BP	GO:0010468	regulation of gene expression	32	3583	6.08e-05
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	65	1206	7.40e-05
GO:BP	GO:0044249	cellular biosynthetic process	85	4465	8.71e-05
KEGG	KEGG:05168	Herpes simplex virus 1 infection	49	415	2.22e-10

##Doxorubicin 3 hour and 24 hour

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	15	3105	4.53e-02
GO:BP	GO:0051252	regulation of RNA metabolic process	14	2849	4.53e-02
GO:BP	GO:1900036	positive regulation of cellular response to heat	1	1	4.53e-02
GO:BP	GO:1904289	regulation of mitotic DNA damage checkpoint	1	3	4.53e-02
GO:BP	GO:1904290	negative regulation of mitotic DNA damage checkpoint	1	1	4.53e-02
GO:BP	GO:0006351	DNA-templated transcription	13	2683	5.00e-02
GO:BP	GO:0006355	regulation of DNA-templated transcription	13	2579	5.00e-02
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	16	3015	5.00e-02
GO:BP	GO:0032774	RNA biosynthetic process	13	2714	5.00e-02
GO:BP	GO:0097659	nucleic acid-templated transcription	13	2684	5.00e-02
GO:BP	GO:1901977	negative regulation of cell cycle checkpoint	1	8	5.00e-02
GO:BP	GO:1903506	regulation of nucleic acid-templated transcription	13	2581	5.00e-02
GO:BP	GO:2000002	negative regulation of DNA damage checkpoint	1	5	5.00e-02
GO:BP	GO:2001141	regulation of RNA biosynthetic process	13	2598	5.00e-02

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0000278	mitotic cell cycle	148	833	2.66e-10
GO:BP	GO:1903047	mitotic cell cycle process	187	700	1.19e-09
GO:BP	GO:0007059	chromosome segregation	84	378	3.00e-09
GO:BP	GO:0000070	mitotic sister chromatid segregation	61	193	3.22e-09
GO:BP	GO:0000819	sister chromatid segregation	79	234	3.25e-09
GO:BP	GO:0140014	mitotic nuclear division	60	264	3.28e-09
GO:BP	GO:0010564	regulation of cell cycle process	118	620	3.28e-09
GO:BP	GO:0051301	cell division	124	567	5.57e-09
GO:BP	GO:0051276	chromosome organization	104	543	7.53e-08
GO:BP	GO:0007093	mitotic cell cycle checkpoint signaling	47	136	7.53e-08
GO:BP	GO:0045930	negative regulation of mitotic cell cycle	59	208	1.29e-07
GO:BP	GO:0022402	cell cycle process	168	1075	1.80e-07
GO:BP	GO:0000075	cell cycle checkpoint signaling	50	180	1.80e-07
GO:BP	GO:0051726	regulation of cell cycle	156	950	2.84e-07
GO:BP	GO:0000280	nuclear division	79	354	5.39e-07
GO:BP	GO:0098813	nuclear chromosome segregation	78	287	1.05e-06
GO:BP	GO:0007051	spindle organization	48	186	1.26e-06
GO:BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	39	156	2.46e-06
GO:BP	GO:0007049	cell cycle	217	1522	2.46e-06
GO:BP	GO:0007052	mitotic spindle organization	34	128	2.46e-06
GO:BP	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	12	18	2.46e-06
GO:BP	GO:0051225	spindle assembly	35	118	6.37e-06
GO:BP	GO:0048285	organelle fission	81	397	6.67e-06
GO:BP	GO:0008608	attachment of spindle microtubules to kinetochore	19	42	7.01e-06
GO:BP	GO:0006974	cellular response to DNA damage stimulus	121	789	8.07e-06
GO:BP	GO:2001251	negative regulation of chromosome organization	39	90	8.34e-06
GO:BP	GO:0007346	regulation of mitotic cell cycle	82	438	8.85e-06
GO:BP	GO:0007080	mitotic metaphase plate congression	20	55	9.77e-06
GO:BP	GO:0090068	positive regulation of cell cycle process	58	206	9.77e-06
GO:BP	GO:0006281	DNA repair	79	535	1.01e-05
GO:BP	GO:0051983	regulation of chromosome segregation	30	118	1.03e-05
GO:BP	GO:1905818	regulation of chromosome separation	27	69	1.07e-05
GO:BP	GO:0010948	negative regulation of cell cycle process	92	270	1.11e-05
GO:BP	GO:1901988	negative regulation of cell cycle phase transition	65	232	1.12e-05
GO:BP	GO:0045786	negative regulation of cell cycle	111	334	1.26e-05
GO:BP	GO:0006261	DNA-templated DNA replication	72	149	1.28e-05
GO:BP	GO:1901987	regulation of cell cycle phase transition	71	388	1.81e-05
GO:BP	GO:0032465	regulation of cytokinesis	28	79	2.49e-05
GO:BP	GO:1903490	positive regulation of mitotic cytokinesis	7	7	2.94e-05
GO:BP	GO:0051310	metaphase plate congression	22	69	2.94e-05
GO:BP	GO:0051231	spindle elongation	9	12	4.02e-05
GO:BP	GO:0031570	DNA integrity checkpoint signaling	46	126	4.48e-05
GO:BP	GO:0051256	mitotic spindle midzone assembly	8	9	4.57e-05
GO:BP	GO:0000226	microtubule cytoskeleton organization	104	552	4.57e-05
GO:BP	GO:0006541	glutamine metabolic process	4	23	4.57e-05
GO:BP	GO:0051304	chromosome separation	27	74	4.68e-05
GO:BP	GO:0006260	DNA replication	124	258	5.59e-05
GO:BP	GO:0033047	regulation of mitotic sister chromatid segregation	20	52	5.66e-05
GO:BP	GO:0033044	regulation of chromosome organization	66	233	5.66e-05
GO:BP	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	36	91	6.55e-05
GO:BP	GO:0044770	cell cycle phase transition	81	499	6.91e-05
GO:BP	GO:0045839	negative regulation of mitotic nuclear division	20	54	7.45e-05
GO:BP	GO:0007088	regulation of mitotic nuclear division	34	100	7.51e-05
GO:BP	GO:1902412	regulation of mitotic cytokinesis	8	8	7.91e-05
GO:BP	GO:0071173	spindle assembly checkpoint signaling	14	44	9.95e-05
GO:BP	GO:0007094	mitotic spindle assembly checkpoint signaling	14	44	9.95e-05
GO:BP	GO:0071174	mitotic spindle checkpoint signaling	14	44	9.95e-05
GO:BP	GO:0000022	mitotic spindle elongation	8	10	9.95e-05
GO:BP	GO:0044774	mitotic DNA integrity checkpoint signaling	29	82	9.98e-05
KEGG	KEGG:04115	p53 signaling pathway	14	65	7.54e-08
KEGG	KEGG:03410	Base excision repair	26	33	4.90e-05
KEGG	KEGG:03030	DNA replication	25	35	8.77e-05

##Epirubicin

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0006366	transcription by RNA polymerase II	141	1991	3.74e-25
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	137	1915	7.44e-25
GO:BP	GO:1903506	regulation of nucleic acid-templated transcription	155	2581	1.99e-21
GO:BP	GO:0006351	DNA-templated transcription	158	2683	1.99e-21
GO:BP	GO:0006355	regulation of DNA-templated transcription	155	2579	1.99e-21
GO:BP	GO:0097659	nucleic acid-templated transcription	158	2684	1.99e-21
GO:BP	GO:2001141	regulation of RNA biosynthetic process	155	2598	3.27e-21
GO:BP	GO:0032774	RNA biosynthetic process	158	2714	4.78e-21
GO:BP	GO:0051252	regulation of RNA metabolic process	162	2849	4.85e-21
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	168	3105	3.83e-20
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	161	3015	2.60e-18
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	161	3083	4.42e-17
GO:BP	GO:0031326	regulation of cellular biosynthetic process	161	3123	1.61e-16
GO:BP	GO:0009889	regulation of biosynthetic process	162	3174	2.73e-16
GO:BP	GO:0018130	heterocycle biosynthetic process	161	3148	2.73e-16
GO:BP	GO:0019438	aromatic compound biosynthetic process	161	3149	3.39e-16
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	161	3253	1.20e-14
GO:BP	GO:0009059	macromolecule biosynthetic process	172	3730	5.33e-14
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	187	4330	5.73e-13
GO:BP	GO:0080090	regulation of primary metabolic process	189	4440	1.97e-12
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	168	3758	5.62e-12
GO:BP	GO:0031323	regulation of cellular metabolic process	182	4305	1.28e-11
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	47	735	8.68e-08
GO:BP	GO:0010468	regulation of gene expression	161	3583	1.16e-07
GO:BP	GO:0044249	cellular biosynthetic process	175	4465	3.13e-07
GO:BP	GO:1901576	organic substance biosynthetic process	175	4537	1.25e-06
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	57	1009	1.77e-06
GO:BP	GO:1903507	negative regulation of nucleic acid-templated transcription	57	1011	1.80e-06
GO:BP	GO:0009058	biosynthetic process	176	4595	2.07e-06
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	57	1020	2.45e-06
GO:BP	GO:0060255	regulation of macromolecule metabolic process	190	4640	6.39e-06
GO:BP	GO:0051253	negative regulation of RNA metabolic process	58	1115	1.54e-05
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	60	1206	2.69e-05
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	61	1249	4.21e-05
GO:BP	GO:0051254	positive regulation of RNA metabolic process	70	1431	5.67e-05
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	66	1304	6.14e-05
GO:BP	GO:1903508	positive regulation of nucleic acid-templated transcription	66	1304	6.14e-05
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	66	1311	6.93e-05
GO:BP	GO:0009890	negative regulation of biosynthetic process	61	1273	7.13e-05
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	59	1215	9.29e-05
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	51	925	2.79e-04
GO:BP	GO:0090304	nucleic acid metabolic process	29	4047	3.48e-04
GO:BP	GO:0010452	histone H3-K36 methylation	5	12	3.71e-04
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	72	1600	5.56e-04
GO:BP	GO:0019827	stem cell population maintenance	14	150	5.63e-04
GO:BP	GO:0098727	maintenance of cell number	14	152	7.12e-04
GO:BP	GO:0019222	regulation of metabolic process	183	5039	9.26e-04
GO:BP	GO:0031324	negative regulation of cellular metabolic process	65	1780	1.08e-03
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	67	1499	1.71e-03
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	29	4503	2.09e-03
GO:BP	GO:0016070	RNA metabolic process	27	3593	2.42e-03
GO:BP	GO:0097676	histone H3-K36 dimethylation	3	4	2.56e-03
GO:BP	GO:0046483	heterocycle metabolic process	25	4616	3.36e-03
GO:BP	GO:0006725	cellular aromatic compound metabolic process	25	4646	3.87e-03
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	66	2425	4.51e-03
GO:BP	GO:1904290	negative regulation of mitotic DNA damage checkpoint	1	1	5.02e-03
GO:BP	GO:1902459	positive regulation of stem cell population maintenance	6	44	5.67e-03
GO:BP	GO:0018205	peptidyl-lysine modification	22	367	6.47e-03
GO:BP	GO:1901360	organic cyclic compound metabolic process	25	4790	6.75e-03
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	65	1866	7.22e-03
GO:BP	GO:2000036	regulation of stem cell population maintenance	7	62	7.22e-03
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	67	1571	7.22e-03
GO:BP	GO:1900034	regulation of cellular response to heat	4	16	8.04e-03
GO:BP	GO:0034641	cellular nitrogen compound metabolic process	25	4991	9.83e-03
KEGG	KEGG:05168	Herpes simplex virus 1 infection	42	415	5.49e-12

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0007059	chromosome segregation	104	378	8.02e-11
GO:BP	GO:0000278	mitotic cell cycle	148	833	8.02e-11
GO:BP	GO:0000070	mitotic sister chromatid segregation	51	193	1.74e-10
GO:BP	GO:0000819	sister chromatid segregation	71	234	1.74e-10
GO:BP	GO:0140014	mitotic nuclear division	63	264	1.92e-10
GO:BP	GO:1903047	mitotic cell cycle process	118	700	4.01e-09
GO:BP	GO:0010564	regulation of cell cycle process	111	620	6.18e-09
GO:BP	GO:0051301	cell division	132	567	7.01e-09
GO:BP	GO:0051726	regulation of cell cycle	160	950	1.50e-08
GO:BP	GO:0098813	nuclear chromosome segregation	81	287	2.06e-08
GO:BP	GO:0022402	cell cycle process	174	1075	3.44e-08
GO:BP	GO:0007093	mitotic cell cycle checkpoint signaling	51	136	5.52e-08
GO:BP	GO:0000075	cell cycle checkpoint signaling	58	180	8.64e-08
GO:BP	GO:0051276	chromosome organization	125	543	1.17e-07
GO:BP	GO:0007049	cell cycle	227	1522	1.58e-07
GO:BP	GO:0045930	negative regulation of mitotic cell cycle	80	208	1.64e-07
GO:BP	GO:0000280	nuclear division	75	354	1.64e-07
GO:BP	GO:0045786	negative regulation of cell cycle	69	334	6.60e-07
GO:BP	GO:0048285	organelle fission	77	397	2.29e-06
GO:BP	GO:0010948	negative regulation of cell cycle process	56	270	4.84e-06
GO:BP	GO:0008608	attachment of spindle microtubules to kinetochore	20	42	5.31e-06
GO:BP	GO:0007051	spindle organization	50	186	7.20e-06
GO:BP	GO:0006974	cellular response to DNA damage stimulus	145	789	9.64e-06
GO:BP	GO:1905818	regulation of chromosome separation	22	69	1.28e-05
GO:BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	36	156	1.28e-05
GO:BP	GO:0051225	spindle assembly	37	118	1.28e-05
GO:BP	GO:1901988	negative regulation of cell cycle phase transition	49	232	1.37e-05
GO:BP	GO:0007052	mitotic spindle organization	31	128	2.06e-05
GO:BP	GO:0051983	regulation of chromosome segregation	35	118	2.55e-05
GO:BP	GO:0006281	DNA repair	114	535	3.28e-05
GO:BP	GO:0071174	mitotic spindle checkpoint signaling	16	44	3.72e-05
GO:BP	GO:0007094	mitotic spindle assembly checkpoint signaling	16	44	3.72e-05
GO:BP	GO:0071173	spindle assembly checkpoint signaling	16	44	3.72e-05
GO:BP	GO:0007346	regulation of mitotic cell cycle	111	438	4.05e-05
GO:BP	GO:0051304	chromosome separation	22	74	4.32e-05
GO:BP	GO:0031577	spindle checkpoint signaling	16	45	4.77e-05
GO:BP	GO:0007080	mitotic metaphase plate congression	13	55	4.81e-05
GO:BP	GO:0045839	negative regulation of mitotic nuclear division	18	54	5.01e-05
GO:BP	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	16	46	6.10e-05
GO:BP	GO:0010965	regulation of mitotic sister chromatid separation	18	58	7.72e-05
GO:BP	GO:0033047	regulation of mitotic sister chromatid segregation	17	52	7.96e-05
GO:BP	GO:0007088	regulation of mitotic nuclear division	27	100	8.54e-05
GO:BP	GO:0031570	DNA integrity checkpoint signaling	39	126	8.54e-05
GO:BP	GO:0006261	DNA-templated DNA replication	46	149	8.54e-05
GO:BP	GO:2001251	negative regulation of chromosome organization	36	90	8.54e-05
GO:BP	GO:1902100	negative regulation of metaphase/anaphase transition of cell cycle	16	47	9.06e-05
GO:BP	GO:0033048	negative regulation of mitotic sister chromatid segregation	16	47	9.06e-05
GO:BP	GO:0033046	negative regulation of sister chromatid segregation	16	47	9.06e-05
GO:BP	GO:2000816	negative regulation of mitotic sister chromatid separation	16	47	9.06e-05
GO:BP	GO:0051310	metaphase plate congression	14	69	9.28e-05
GO:BP	GO:0006541	glutamine metabolic process	4	23	1.18e-04
GO:BP	GO:0006260	DNA replication	74	258	1.18e-04
GO:BP	GO:1901987	regulation of cell cycle phase transition	67	388	1.18e-04
GO:BP	GO:0030071	regulation of mitotic metaphase/anaphase transition	22	88	1.18e-04
GO:BP	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	11	18	1.18e-04
GO:BP	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	29	91	1.18e-04
GO:BP	GO:0051306	mitotic sister chromatid separation	18	61	1.18e-04
GO:BP	GO:0051783	regulation of nuclear division	29	115	1.26e-04
GO:BP	GO:0051985	negative regulation of chromosome segregation	16	48	1.33e-04
GO:BP	GO:1901991	negative regulation of mitotic cell cycle phase transition	33	163	1.33e-04
GO:BP	GO:1905819	negative regulation of chromosome separation	16	48	1.33e-04
GO:BP	GO:0090068	positive regulation of cell cycle process	55	206	1.55e-04
GO:BP	GO:0044774	mitotic DNA integrity checkpoint signaling	30	82	1.67e-04
GO:BP	GO:0032465	regulation of cytokinesis	22	79	1.71e-04
GO:BP	GO:1902099	regulation of metaphase/anaphase transition of cell cycle	22	89	1.75e-04
GO:BP	GO:0051784	negative regulation of nuclear division	18	57	1.97e-04
GO:BP	GO:0051984	positive regulation of chromosome segregation	16	25	1.97e-04
GO:BP	GO:0044784	metaphase/anaphase transition of cell cycle	29	92	1.97e-04
GO:BP	GO:0051231	spindle elongation	8	12	2.45e-04
GO:BP	GO:0033045	regulation of sister chromatid segregation	34	99	2.46e-04
GO:BP	GO:0010639	negative regulation of organelle organization	31	318	2.88e-04
GO:BP	GO:0044770	cell cycle phase transition	79	499	2.88e-04
GO:BP	GO:0051256	mitotic spindle midzone assembly	8	9	2.93e-04
GO:BP	GO:1901990	regulation of mitotic cell cycle phase transition	29	305	2.93e-04
GO:BP	GO:0051255	spindle midzone assembly	9	12	2.98e-04
GO:BP	GO:0051303	establishment of chromosome localization	14	75	4.18e-04
GO:BP	GO:0090307	mitotic spindle assembly	13	69	4.28e-04
GO:BP	GO:0006270	DNA replication initiation	19	35	4.34e-04
GO:BP	GO:0044773	mitotic DNA damage checkpoint signaling	28	78	4.97e-04
GO:BP	GO:0000226	microtubule cytoskeleton organization	85	552	5.55e-04
GO:BP	GO:0000077	DNA damage checkpoint signaling	27	118	5.64e-04
GO:BP	GO:0044772	mitotic cell cycle phase transition	78	413	6.33e-04
GO:BP	GO:0042770	signal transduction in response to DNA damage	35	173	6.33e-04
GO:BP	GO:0033044	regulation of chromosome organization	54	233	6.96e-04
GO:BP	GO:0000022	mitotic spindle elongation	8	10	6.96e-04
GO:BP	GO:0019985	translesion synthesis	11	24	7.04e-04
GO:BP	GO:0050000	chromosome localization	16	82	7.31e-04
GO:BP	GO:0006301	postreplication repair	13	34	9.16e-04
GO:BP	GO:0033043	regulation of organelle organization	68	1023	1.03e-03
GO:BP	GO:0010389	regulation of G2/M transition of mitotic cell cycle	29	92	1.03e-03
GO:BP	GO:0000731	DNA synthesis involved in DNA repair	16	36	1.08e-03
GO:BP	GO:0000281	mitotic cytokinesis	20	81	1.20e-03
GO:BP	GO:0000086	G2/M transition of mitotic cell cycle	37	134	1.44e-03
GO:BP	GO:0010212	response to ionizing radiation	37	130	1.48e-03
GO:BP	GO:0051383	kinetochore organization	10	23	1.55e-03
GO:BP	GO:0006275	regulation of DNA replication	45	124	1.55e-03
GO:BP	GO:0000910	cytokinesis	32	163	2.02e-03
GO:BP	GO:0051302	regulation of cell division	19	144	2.07e-03
GO:BP	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	12	21	2.09e-03
GO:BP	GO:0006167	AMP biosynthetic process	3	14	2.15e-03
GO:BP	GO:0060236	regulation of mitotic spindle organization	8	42	2.28e-03
GO:BP	GO:0090329	regulation of DNA-templated DNA replication	24	54	2.46e-03
GO:BP	GO:0044839	cell cycle G2/M phase transition	39	148	2.49e-03
GO:BP	GO:0006177	GMP biosynthetic process	3	14	2.57e-03
GO:BP	GO:0006271	DNA strand elongation involved in DNA replication	13	15	3.17e-03
GO:BP	GO:0009411	response to UV	29	137	3.20e-03
GO:BP	GO:0044818	mitotic G2/M transition checkpoint	19	50	3.50e-03
GO:BP	GO:1903490	positive regulation of mitotic cytokinesis	6	7	3.65e-03
GO:BP	GO:0090224	regulation of spindle organization	8	45	4.05e-03
GO:BP	GO:0046060	dATP metabolic process	2	3	4.67e-03
GO:BP	GO:0032508	DNA duplex unwinding	24	75	5.30e-03
GO:BP	GO:0009064	glutamine family amino acid metabolic process	4	61	5.72e-03
GO:BP	GO:0006259	DNA metabolic process	167	890	5.72e-03
GO:BP	GO:1902412	regulation of mitotic cytokinesis	7	8	6.05e-03
GO:BP	GO:1905820	positive regulation of chromosome separation	11	26	6.77e-03
GO:BP	GO:1902749	regulation of cell cycle G2/M phase transition	29	102	6.96e-03
GO:BP	GO:0007098	centrosome cycle	26	126	6.96e-03
GO:BP	GO:0061640	cytoskeleton-dependent cytokinesis	22	103	7.19e-03
GO:BP	GO:0044314	protein K27-linked ubiquitination	8	8	7.51e-03
GO:BP	GO:0036166	phenotypic switching	5	7	7.55e-03
GO:BP	GO:0060623	regulation of chromosome condensation	6	9	7.69e-03
GO:BP	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	21	60	8.01e-03
GO:BP	GO:0030330	DNA damage response, signal transduction by p53 class mediator	10	68	8.01e-03
GO:BP	GO:1901976	regulation of cell cycle checkpoint	13	45	8.09e-03
GO:BP	GO:0045005	DNA-templated DNA replication maintenance of fidelity	17	50	8.09e-03
GO:BP	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	3	22	8.09e-03
GO:BP	GO:0046602	regulation of mitotic centrosome separation	6	8	8.21e-03
GO:BP	GO:0009127	purine nucleoside monophosphate biosynthetic process	3	24	1.02e-02
GO:BP	GO:0046033	AMP metabolic process	3	22	1.02e-02
GO:BP	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore	8	11	1.09e-02
GO:BP	GO:0045787	positive regulation of cell cycle	64	278	1.10e-02
GO:BP	GO:0006284	base-excision repair	28	44	1.12e-02
GO:BP	GO:0031023	microtubule organizing center organization	27	136	1.16e-02
GO:BP	GO:1902750	negative regulation of cell cycle G2/M phase transition	21	62	1.22e-02
GO:BP	GO:0044209	AMP salvage	2	5	1.25e-02
GO:BP	GO:0032263	GMP salvage	2	4	1.25e-02
GO:BP	GO:0007095	mitotic G2 DNA damage checkpoint signaling	14	35	1.25e-02
GO:BP	GO:1902423	regulation of attachment of mitotic spindle microtubules to kinetochore	6	8	1.30e-02
GO:BP	GO:1902425	positive regulation of attachment of mitotic spindle microtubules to kinetochore	6	8	1.30e-02
GO:BP	GO:1903046	meiotic cell cycle process	42	136	1.30e-02
GO:BP	GO:1902969	mitotic DNA replication	10	14	1.30e-02
GO:BP	GO:0046037	GMP metabolic process	3	24	1.31e-02
GO:BP	GO:0044786	cell cycle DNA replication	15	40	1.35e-02
GO:BP	GO:0032392	DNA geometric change	24	81	1.42e-02
GO:BP	GO:0046112	nucleobase biosynthetic process	9	18	1.46e-02
GO:BP	GO:0007017	microtubule-based process	99	756	1.48e-02
GO:BP	GO:0140013	meiotic nuclear division	39	121	1.54e-02
GO:BP	GO:1902117	positive regulation of organelle assembly	10	75	1.69e-02
GO:BP	GO:0071478	cellular response to radiation	43	155	1.69e-02
GO:BP	GO:0086067	AV node cell to bundle of His cell communication	4	11	1.69e-02
GO:BP	GO:0034501	protein localization to kinetochore	11	18	1.69e-02
GO:BP	GO:1903083	protein localization to condensed chromosome	11	18	1.69e-02
GO:BP	GO:0030174	regulation of DNA-templated DNA replication initiation	9	14	1.74e-02
GO:BP	GO:0033554	cellular response to stress	229	1677	1.74e-02
GO:BP	GO:0034644	cellular response to UV	22	83	1.82e-02
GO:BP	GO:1902115	regulation of organelle assembly	17	186	1.84e-02
GO:BP	GO:0071214	cellular response to abiotic stimulus	49	264	1.90e-02
GO:BP	GO:0104004	cellular response to environmental stimulus	49	264	1.90e-02
GO:BP	GO:0140694	non-membrane-bounded organelle assembly	54	355	2.05e-02
GO:BP	GO:0009112	nucleobase metabolic process	3	27	2.09e-02
GO:BP	GO:0071103	DNA conformation change	25	88	2.10e-02
GO:BP	GO:0007099	centriole replication	3	38	2.15e-02
GO:BP	GO:0046053	dAMP metabolic process	2	5	2.17e-02
GO:BP	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process	2	7	2.17e-02
GO:BP	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	11	13	2.19e-02
GO:BP	GO:0051129	negative regulation of cellular component organization	41	586	2.19e-02
GO:BP	GO:1900262	regulation of DNA-directed DNA polymerase activity	11	13	2.19e-02
GO:BP	GO:0071480	cellular response to gamma radiation	17	29	2.19e-02
GO:BP	GO:0042148	strand invasion	4	5	2.29e-02
GO:BP	GO:0051299	centrosome separation	13	14	2.30e-02
GO:BP	GO:0006285	base-excision repair, AP site formation	10	12	2.30e-02
GO:BP	GO:0009314	response to radiation	59	349	2.31e-02
GO:BP	GO:0007076	mitotic chromosome condensation	8	19	2.34e-02
GO:BP	GO:0060444	branching involved in mammary gland duct morphogenesis	11	20	2.45e-02
GO:BP	GO:1905832	positive regulation of spindle assembly	5	7	2.49e-02
GO:BP	GO:0006268	DNA unwinding involved in DNA replication	11	22	2.59e-02
GO:BP	GO:0098534	centriole assembly	3	41	2.59e-02
GO:BP	GO:0071897	DNA biosynthetic process	61	175	2.65e-02
GO:BP	GO:0106380	purine ribonucleotide salvage	2	7	2.65e-02
GO:BP	GO:0010032	meiotic chromosome condensation	4	6	2.68e-02
GO:BP	GO:0007079	mitotic chromosome movement towards spindle pole	3	4	2.70e-02
GO:BP	GO:0007062	sister chromatid cohesion	29	51	2.90e-02
GO:BP	GO:0051321	meiotic cell cycle	51	188	2.90e-02
GO:BP	GO:0009156	ribonucleoside monophosphate biosynthetic process	14	36	2.93e-02
GO:BP	GO:0009084	glutamine family amino acid biosynthetic process	2	17	2.97e-02
GO:BP	GO:0071479	cellular response to ionizing radiation	23	68	3.14e-02
GO:BP	GO:0061642	chemoattraction of axon	2	2	3.20e-02
GO:BP	GO:0030510	regulation of BMP signaling pathway	4	84	3.20e-02
GO:BP	GO:0009200	deoxyribonucleoside triphosphate metabolic process	2	9	3.22e-02
GO:BP	GO:0009124	nucleoside monophosphate biosynthetic process	16	44	3.35e-02
GO:BP	GO:1905821	positive regulation of chromosome condensation	4	5	3.37e-02
GO:BP	GO:0033260	nuclear DNA replication	13	35	3.43e-02
GO:BP	GO:0006290	pyrimidine dimer repair	1	7	3.45e-02
GO:BP	GO:1901751	leukotriene A4 metabolic process	2	2	3.73e-02
GO:BP	GO:0097294	‘de novo’ XMP biosynthetic process	5	7	3.79e-02
GO:BP	GO:0097293	XMP biosynthetic process	5	7	3.79e-02
GO:BP	GO:0097292	XMP metabolic process	5	7	3.79e-02
GO:BP	GO:0009170	purine deoxyribonucleoside monophosphate metabolic process	2	7	3.83e-02
GO:BP	GO:0009167	purine ribonucleoside monophosphate metabolic process	3	40	3.88e-02
GO:BP	GO:0009113	purine nucleobase biosynthetic process	6	10	4.02e-02
GO:BP	GO:0007100	mitotic centrosome separation	12	13	4.23e-02
GO:BP	GO:0090232	positive regulation of spindle checkpoint	6	12	4.27e-02
GO:BP	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	6	12	4.27e-02
GO:BP	GO:0009126	purine nucleoside monophosphate metabolic process	3	42	4.30e-02
GO:BP	GO:0090235	regulation of metaphase plate congression	7	13	4.40e-02
GO:BP	GO:0046601	positive regulation of centriole replication	5	9	4.40e-02
GO:BP	GO:0046129	purine ribonucleoside biosynthetic process	2	11	4.40e-02
GO:BP	GO:0042455	ribonucleoside biosynthetic process	2	11	4.40e-02
GO:BP	GO:0042451	purine nucleoside biosynthetic process	2	11	4.40e-02
GO:BP	GO:0032261	purine nucleotide salvage	2	10	4.40e-02
GO:BP	GO:1990227	paranodal junction maintenance	1	2	4.51e-02
GO:BP	GO:0006302	double-strand break repair	78	270	4.65e-02
GO:BP	GO:0034508	centromere complex assembly	9	30	4.66e-02
GO:BP	GO:0051298	centrosome duplication	7	68	4.81e-02
GO:BP	GO:0060509	type I pneumocyte differentiation	8	8	4.82e-02
GO:BP	GO:0034599	cellular response to oxidative stress	30	239	4.91e-02
GO:BP	GO:0010332	response to gamma radiation	26	50	4.98e-02
GO:BP	GO:0044837	actomyosin contractile ring organization	4	7	5.00e-02
KEGG	KEGG:04115	p53 signaling pathway	10	65	5.67e-06
KEGG	KEGG:03410	Base excision repair	26	33	1.87e-05
KEGG	KEGG:04110	Cell cycle	11	121	1.47e-04
KEGG	KEGG:03030	DNA replication	13	35	4.27e-04
KEGG	KEGG:03430	Mismatch repair	17	22	1.79e-03
KEGG	KEGG:03440	Homologous recombination	11	39	6.99e-03
KEGG	KEGG:05322	Systemic lupus erythematosus	2	61	2.65e-02
KEGG	KEGG:04217	Necroptosis	7	106	2.65e-02
KEGG	KEGG:00230	Purine metabolism	4	97	3.74e-02
KEGG	KEGG:05034	Alcoholism	2	122	3.74e-02
KEGG	KEGG:04613	Neutrophil extracellular trap formation	2	110	3.74e-02
KEGG	KEGG:01524	Platinum drug resistance	26	65	3.84e-02

##Mitoxantrone 3 hour = 104 24 hour = 1560

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	52	1915	2.46e-10
GO:BP	GO:0006355	regulation of DNA-templated transcription	59	2579	6.00e-10
GO:BP	GO:0006366	transcription by RNA polymerase II	52	1991	6.00e-10
GO:BP	GO:1903506	regulation of nucleic acid-templated transcription	59	2581	6.00e-10
GO:BP	GO:0051252	regulation of RNA metabolic process	62	2849	6.00e-10
GO:BP	GO:2001141	regulation of RNA biosynthetic process	59	2598	6.77e-10
GO:BP	GO:0006351	DNA-templated transcription	59	2683	1.72e-09
GO:BP	GO:0097659	nucleic acid-templated transcription	59	2684	1.72e-09
GO:BP	GO:0032774	RNA biosynthetic process	59	2714	2.43e-09
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	62	3105	9.96e-09
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	60	3015	2.93e-08
GO:BP	GO:0031326	regulation of cellular biosynthetic process	60	3123	1.51e-07
GO:BP	GO:0009889	regulation of biosynthetic process	60	3174	2.62e-07
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	59	3083	2.62e-07
GO:BP	GO:0018130	heterocycle biosynthetic process	59	3148	5.44e-07
GO:BP	GO:0019438	aromatic compound biosynthetic process	59	3149	5.70e-07
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	23	735	7.30e-07
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	59	3253	2.00e-06
GO:BP	GO:0051253	negative regulation of RNA metabolic process	31	1115	2.00e-06
GO:BP	GO:1903507	negative regulation of nucleic acid-templated transcription	29	1011	3.41e-06
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	29	1009	3.41e-06
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	57	4330	3.41e-06
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	29	1020	4.13e-06
GO:BP	GO:0080090	regulation of primary metabolic process	57	4440	9.06e-06
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	62	3758	1.00e-05
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	31	1215	1.02e-05
GO:BP	GO:0010468	regulation of gene expression	54	3583	2.20e-05
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	30	1206	2.28e-05
GO:BP	GO:0009059	macromolecule biosynthetic process	60	3730	4.08e-05
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	30	1249	4.82e-05
GO:BP	GO:0031323	regulation of cellular metabolic process	66	4305	5.49e-05
GO:BP	GO:0009890	negative regulation of biosynthetic process	30	1273	6.82e-05

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:1903047	mitotic cell cycle process	103	700	2.48e-66
GO:BP	GO:0022402	cell cycle process	125	1075	2.48e-66
GO:BP	GO:0000278	mitotic cell cycle	108	833	4.08e-64
GO:BP	GO:0007049	cell cycle	140	1522	1.58e-63
GO:BP	GO:0007059	chromosome segregation	77	378	4.76e-56
GO:BP	GO:0051276	chromosome organization	85	543	1.10e-55
GO:BP	GO:0098813	nuclear chromosome segregation	65	287	1.05e-51
GO:BP	GO:0000280	nuclear division	73	354	1.09e-51
GO:BP	GO:0051301	cell division	81	567	6.13e-50
GO:BP	GO:0010564	regulation of cell cycle process	97	620	1.67e-49
GO:BP	GO:0140014	mitotic nuclear division	61	264	3.25e-49
GO:BP	GO:0048285	organelle fission	73	397	9.61e-49
GO:BP	GO:0000819	sister chromatid segregation	57	234	5.11e-48
GO:BP	GO:0000070	mitotic sister chromatid segregation	54	193	6.70e-48
GO:BP	GO:0051726	regulation of cell cycle	125	950	1.19e-42
GO:BP	GO:0044770	cell cycle phase transition	77	499	4.38e-39
GO:BP	GO:0006261	DNA-templated DNA replication	62	149	1.40e-38
GO:BP	GO:0006260	DNA replication	79	258	4.51e-37
GO:BP	GO:1901987	regulation of cell cycle phase transition	74	388	7.28e-36
GO:BP	GO:0000075	cell cycle checkpoint signaling	52	180	5.34e-35
GO:BP	GO:0044772	mitotic cell cycle phase transition	86	413	3.78e-34
GO:BP	GO:0006259	DNA metabolic process	149	890	9.88e-33
GO:BP	GO:0007346	regulation of mitotic cell cycle	74	438	5.51e-32
GO:BP	GO:0007093	mitotic cell cycle checkpoint signaling	44	136	6.54e-32
GO:BP	GO:1901988	negative regulation of cell cycle phase transition	54	232	2.67e-30
GO:BP	GO:1901990	regulation of mitotic cell cycle phase transition	60	305	4.79e-30
GO:BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	34	156	9.01e-30
GO:BP	GO:0010948	negative regulation of cell cycle process	51	270	1.22e-29
GO:BP	GO:0006974	cellular response to DNA damage stimulus	126	789	1.71e-29
GO:BP	GO:0051983	regulation of chromosome segregation	33	118	2.27e-29
GO:BP	GO:0007051	spindle organization	26	186	1.62e-28
GO:BP	GO:0006281	DNA repair	99	535	4.24e-28
GO:BP	GO:0090068	positive regulation of cell cycle process	42	206	1.46e-27
GO:BP	GO:0000226	microtubule cytoskeleton organization	51	552	7.91e-27
GO:BP	GO:1905818	regulation of chromosome separation	26	69	8.32e-27
GO:BP	GO:0045786	negative regulation of cell cycle	59	334	1.35e-26
GO:BP	GO:0045930	negative regulation of mitotic cell cycle	55	208	1.42e-26
GO:BP	GO:0007088	regulation of mitotic nuclear division	30	100	2.62e-26
GO:BP	GO:0007052	mitotic spindle organization	22	128	3.87e-26
GO:BP	GO:0051304	chromosome separation	26	74	7.55e-26
GO:BP	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	22	91	2.11e-25
GO:BP	GO:0044784	metaphase/anaphase transition of cell cycle	22	92	4.39e-25
GO:BP	GO:0051783	regulation of nuclear division	31	115	8.34e-25
GO:BP	GO:0033045	regulation of sister chromatid segregation	22	99	2.78e-24
GO:BP	GO:0030071	regulation of mitotic metaphase/anaphase transition	21	88	4.70e-24
GO:BP	GO:0045787	positive regulation of cell cycle	44	278	9.41e-24
GO:BP	GO:1902099	regulation of metaphase/anaphase transition of cell cycle	21	89	9.44e-24
GO:BP	GO:0010965	regulation of mitotic sister chromatid separation	18	58	2.43e-23
GO:BP	GO:1901991	negative regulation of mitotic cell cycle phase transition	40	163	2.43e-23
GO:BP	GO:0051306	mitotic sister chromatid separation	18	61	6.31e-23
GO:BP	GO:0007017	microtubule-based process	55	756	1.19e-22
GO:BP	GO:0033044	regulation of chromosome organization	27	233	2.61e-22
GO:BP	GO:0008608	attachment of spindle microtubules to kinetochore	17	42	3.23e-22
GO:BP	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	20	46	3.47e-22
GO:BP	GO:0007094	mitotic spindle assembly checkpoint signaling	16	44	6.15e-22
GO:BP	GO:0071173	spindle assembly checkpoint signaling	16	44	6.15e-22
GO:BP	GO:0071174	mitotic spindle checkpoint signaling	16	44	6.15e-22
GO:BP	GO:0033048	negative regulation of mitotic sister chromatid segregation	20	47	8.21e-22
GO:BP	GO:1902100	negative regulation of metaphase/anaphase transition of cell cycle	20	47	8.21e-22
GO:BP	GO:2000816	negative regulation of mitotic sister chromatid separation	20	47	8.21e-22
GO:BP	GO:0033046	negative regulation of sister chromatid segregation	20	47	8.21e-22
GO:BP	GO:0031577	spindle checkpoint signaling	16	45	8.44e-22
GO:BP	GO:0045839	negative regulation of mitotic nuclear division	27	54	1.10e-21
GO:BP	GO:0006270	DNA replication initiation	23	35	1.67e-21
GO:BP	GO:1905819	negative regulation of chromosome separation	20	48	1.93e-21
GO:BP	GO:0051985	negative regulation of chromosome segregation	20	48	1.93e-21
GO:BP	GO:2001251	negative regulation of chromosome organization	19	90	3.66e-21
GO:BP	GO:0031570	DNA integrity checkpoint signaling	33	126	3.66e-21
GO:BP	GO:0006996	organelle organization	101	2971	4.76e-21
GO:BP	GO:0033047	regulation of mitotic sister chromatid segregation	20	52	6.80e-21
GO:BP	GO:0051784	negative regulation of nuclear division	27	57	4.62e-20
GO:BP	GO:0051321	meiotic cell cycle	34	188	1.14e-19
GO:BP	GO:0090329	regulation of DNA-templated DNA replication	24	54	1.47e-19
GO:BP	GO:0051225	spindle assembly	28	118	1.60e-19
GO:BP	GO:0051310	metaphase plate congression	21	69	7.80e-19
GO:BP	GO:1903046	meiotic cell cycle process	48	136	2.09e-18
GO:BP	GO:0140013	meiotic nuclear division	28	121	3.07e-18
GO:BP	GO:0050000	chromosome localization	20	82	7.01e-18
GO:BP	GO:0044839	cell cycle G2/M phase transition	33	148	9.41e-18
GO:BP	GO:0032392	DNA geometric change	28	81	1.62e-17
GO:BP	GO:0071103	DNA conformation change	29	88	1.88e-17
GO:BP	GO:0051303	establishment of chromosome localization	21	75	2.40e-17
GO:BP	GO:0032508	DNA duplex unwinding	27	75	2.49e-17
GO:BP	GO:0000086	G2/M transition of mitotic cell cycle	31	134	3.79e-17
GO:BP	GO:0007080	mitotic metaphase plate congression	18	55	9.81e-17
GO:BP	GO:0033554	cellular response to stress	170	1677	3.42e-16
GO:BP	GO:0140694	non-membrane-bounded organelle assembly	22	355	4.12e-16
GO:BP	GO:0033260	nuclear DNA replication	23	35	8.52e-16
GO:BP	GO:0006275	regulation of DNA replication	30	124	1.08e-15
GO:BP	GO:0000077	DNA damage checkpoint signaling	27	118	1.38e-15
GO:BP	GO:0090307	mitotic spindle assembly	13	69	1.74e-15
GO:BP	GO:0044774	mitotic DNA integrity checkpoint signaling	23	82	2.15e-15
GO:BP	GO:0044786	cell cycle DNA replication	24	40	2.15e-15
GO:BP	GO:0006310	DNA recombination	55	256	2.27e-15
GO:BP	GO:0006302	double-strand break repair	49	270	2.38e-15
GO:BP	GO:0042770	signal transduction in response to DNA damage	32	173	6.36e-15
GO:BP	GO:0007010	cytoskeleton organization	36	1222	1.07e-14
GO:BP	GO:0033043	regulation of organelle organization	58	1023	2.74e-14
GO:BP	GO:0045132	meiotic chromosome segregation	19	69	8.53e-14
GO:BP	GO:0010389	regulation of G2/M transition of mitotic cell cycle	23	92	8.53e-14
GO:BP	GO:0044773	mitotic DNA damage checkpoint signaling	21	78	1.31e-13
GO:BP	GO:1901976	regulation of cell cycle checkpoint	13	45	2.92e-13
GO:BP	GO:0000281	mitotic cytokinesis	18	81	4.28e-13
GO:BP	GO:1901989	positive regulation of cell cycle phase transition	21	103	4.50e-13
GO:BP	GO:1901992	positive regulation of mitotic cell cycle phase transition	19	86	6.85e-13
GO:BP	GO:1902749	regulation of cell cycle G2/M phase transition	23	102	9.36e-13
GO:BP	GO:0051984	positive regulation of chromosome segregation	13	25	1.03e-12
GO:BP	GO:0000725	recombinational repair	36	151	1.12e-12
GO:BP	GO:0000910	cytokinesis	24	163	1.16e-12
GO:BP	GO:0006268	DNA unwinding involved in DNA replication	13	22	1.25e-12
GO:BP	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	10	18	1.69e-12
GO:BP	GO:0061982	meiosis I cell cycle process	31	80	1.73e-12
GO:BP	GO:0000724	double-strand break repair via homologous recombination	46	147	2.17e-12
GO:BP	GO:0034508	centromere complex assembly	16	30	2.27e-12
GO:BP	GO:0051231	spindle elongation	8	12	2.32e-12
GO:BP	GO:0051052	regulation of DNA metabolic process	68	459	2.83e-12
GO:BP	GO:1905820	positive regulation of chromosome separation	11	26	4.58e-12
GO:BP	GO:0045931	positive regulation of mitotic cell cycle	20	113	1.30e-11
GO:BP	GO:0010639	negative regulation of organelle organization	20	318	1.59e-11
GO:BP	GO:0051256	mitotic spindle midzone assembly	8	9	1.62e-11
GO:BP	GO:0032465	regulation of cytokinesis	17	79	1.77e-11
GO:BP	GO:0045005	DNA-templated DNA replication maintenance of fidelity	23	50	2.40e-11
GO:BP	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	8	21	2.56e-11
GO:BP	GO:0061640	cytoskeleton-dependent cytokinesis	14	103	2.89e-11
GO:BP	GO:0000022	mitotic spindle elongation	8	10	4.59e-11
GO:BP	GO:0051302	regulation of cell division	22	144	6.91e-11
GO:BP	GO:0034502	protein localization to chromosome	31	110	9.43e-11
GO:BP	GO:1902969	mitotic DNA replication	10	14	9.71e-11
GO:BP	GO:0000727	double-strand break repair via break-induced replication	10	11	1.21e-10
GO:BP	GO:0007127	meiosis I	28	76	1.23e-10
GO:BP	GO:0051383	kinetochore organization	9	23	2.17e-10
GO:BP	GO:0007098	centrosome cycle	28	126	2.21e-10
GO:BP	GO:0051255	spindle midzone assembly	8	12	2.56e-10
GO:BP	GO:0071897	DNA biosynthetic process	36	175	2.86e-10
GO:BP	GO:0032467	positive regulation of cytokinesis	12	33	4.19e-10
GO:BP	GO:1900262	regulation of DNA-directed DNA polymerase activity	10	13	4.74e-10
GO:BP	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	10	13	4.74e-10
GO:BP	GO:0051656	establishment of organelle localization	26	375	1.55e-09
GO:BP	GO:0071459	protein localization to chromosome, centromeric region	16	42	1.62e-09
GO:BP	GO:0030174	regulation of DNA-templated DNA replication initiation	7	14	2.08e-09
GO:BP	GO:0031023	microtubule organizing center organization	28	136	2.08e-09
GO:BP	GO:1903504	regulation of mitotic spindle checkpoint	7	19	2.69e-09
GO:BP	GO:0090231	regulation of spindle checkpoint	7	19	2.69e-09
GO:BP	GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint	7	19	2.69e-09
GO:BP	GO:0070925	organelle assembly	23	803	2.78e-09
GO:BP	GO:0006271	DNA strand elongation involved in DNA replication	10	15	3.26e-09
GO:BP	GO:0000076	DNA replication checkpoint signaling	9	15	4.02e-09
GO:BP	GO:0010212	response to ionizing radiation	21	130	5.21e-09
GO:BP	GO:0030261	chromosome condensation	10	34	5.28e-09
GO:BP	GO:0090224	regulation of spindle organization	12	45	6.24e-09
GO:BP	GO:0051640	organelle localization	21	498	6.36e-09
GO:BP	GO:0065004	protein-DNA complex assembly	27	185	9.04e-09
GO:BP	GO:0051653	spindle localization	11	52	1.23e-08
GO:BP	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	17	87	2.73e-08
GO:BP	GO:0031297	replication fork processing	18	42	2.80e-08
GO:BP	GO:1903083	protein localization to condensed chromosome	10	18	3.21e-08
GO:BP	GO:0034501	protein localization to kinetochore	10	18	3.21e-08
GO:BP	GO:0051128	regulation of cellular component organization	42	1947	3.46e-08
GO:BP	GO:0060236	regulation of mitotic spindle organization	11	42	3.65e-08
GO:BP	GO:1904029	regulation of cyclin-dependent protein kinase activity	17	90	3.99e-08
GO:BP	GO:0007062	sister chromatid cohesion	11	51	4.41e-08
GO:BP	GO:0071824	protein-DNA complex subunit organization	27	204	5.29e-08
GO:BP	GO:1901970	positive regulation of mitotic sister chromatid separation	6	18	7.34e-08
GO:BP	GO:0040001	establishment of mitotic spindle localization	9	36	7.65e-08
GO:BP	GO:0051129	negative regulation of cellular component organization	18	586	7.93e-08
GO:BP	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	10	60	8.07e-08
GO:BP	GO:0051293	establishment of spindle localization	10	48	8.68e-08
GO:BP	GO:1901978	positive regulation of cell cycle checkpoint	6	19	8.76e-08
GO:BP	GO:0007143	female meiotic nuclear division	6	25	9.63e-08
GO:BP	GO:1902750	negative regulation of cell cycle G2/M phase transition	10	62	1.08e-07
GO:BP	GO:0035825	homologous recombination	17	43	1.56e-07
GO:BP	GO:0007095	mitotic G2 DNA damage checkpoint signaling	8	35	1.67e-07
GO:BP	GO:0044818	mitotic G2/M transition checkpoint	9	50	1.96e-07
GO:BP	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	10	27	2.55e-07
GO:BP	GO:0070192	chromosome organization involved in meiotic cell cycle	18	44	3.11e-07
GO:BP	GO:0090232	positive regulation of spindle checkpoint	6	12	3.11e-07
GO:BP	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	6	12	3.11e-07
GO:BP	GO:0072331	signal transduction by p53 class mediator	29	160	4.83e-07
GO:BP	GO:0000731	DNA synthesis involved in DNA repair	15	36	5.16e-07
GO:BP	GO:0008315	G2/MI transition of meiotic cell cycle	5	5	5.21e-07
GO:BP	GO:1903490	positive regulation of mitotic cytokinesis	5	7	5.21e-07
GO:BP	GO:0044771	meiotic cell cycle phase transition	6	7	6.67e-07
GO:BP	GO:1902751	positive regulation of cell cycle G2/M phase transition	10	30	7.55e-07
GO:BP	GO:0044260	cellular macromolecule metabolic process	141	2777	1.26e-06
GO:BP	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	20	76	1.36e-06
GO:BP	GO:0071479	cellular response to ionizing radiation	11	68	1.42e-06
GO:BP	GO:0007076	mitotic chromosome condensation	10	19	1.52e-06
GO:BP	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	14	43	1.66e-06
GO:BP	GO:0000082	G1/S transition of mitotic cell cycle	31	203	1.66e-06
GO:BP	GO:0051294	establishment of spindle orientation	8	36	1.80e-06
GO:BP	GO:1902315	nuclear cell cycle DNA replication initiation	5	5	1.80e-06
GO:BP	GO:1902292	cell cycle DNA replication initiation	5	5	1.80e-06
GO:BP	GO:1902975	mitotic DNA replication initiation	5	5	1.80e-06
GO:BP	GO:0044843	cell cycle G1/S phase transition	30	225	2.01e-06
GO:BP	GO:0051781	positive regulation of cell division	12	64	2.06e-06
GO:BP	GO:0051298	centrosome duplication	16	68	2.42e-06
GO:BP	GO:0009314	response to radiation	46	349	2.67e-06
GO:BP	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore	6	11	2.75e-06
GO:BP	GO:0051054	positive regulation of DNA metabolic process	44	261	4.34e-06
GO:BP	GO:0051382	kinetochore assembly	4	18	4.44e-06
GO:BP	GO:1902412	regulation of mitotic cytokinesis	5	8	5.43e-06
GO:BP	GO:1905832	positive regulation of spindle assembly	5	7	5.85e-06
GO:BP	GO:1903932	regulation of DNA primase activity	5	5	7.23e-06
GO:BP	GO:1903934	positive regulation of DNA primase activity	5	5	7.23e-06
GO:BP	GO:0071478	cellular response to radiation	26	155	8.14e-06
GO:BP	GO:1905821	positive regulation of chromosome condensation	5	5	8.55e-06
GO:BP	GO:0000132	establishment of mitotic spindle orientation	7	31	8.73e-06
GO:BP	GO:0051338	regulation of transferase activity	46	713	9.06e-06
GO:BP	GO:0090235	regulation of metaphase plate congression	6	13	9.31e-06
GO:BP	GO:0070507	regulation of microtubule cytoskeleton organization	12	146	9.67e-06
GO:BP	GO:0090169	regulation of spindle assembly	8	32	1.09e-05
GO:BP	GO:0032506	cytokinetic process	8	39	1.11e-05
GO:BP	GO:1902423	regulation of attachment of mitotic spindle microtubules to kinetochore	5	8	1.39e-05
GO:BP	GO:1902425	positive regulation of attachment of mitotic spindle microtubules to kinetochore	5	8	1.39e-05
GO:BP	GO:2000001	regulation of DNA damage checkpoint	6	25	1.45e-05
GO:BP	GO:0007131	reciprocal meiotic recombination	13	36	1.45e-05
GO:BP	GO:0140527	reciprocal homologous recombination	13	36	1.45e-05
GO:BP	GO:0000212	meiotic spindle organization	4	14	1.46e-05
GO:BP	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	9	15	1.59e-05
GO:BP	GO:0022616	DNA strand elongation	11	35	1.87e-05
GO:BP	GO:0010332	response to gamma radiation	10	50	2.09e-05
GO:BP	GO:0051053	negative regulation of DNA metabolic process	26	118	2.18e-05
GO:BP	GO:0036297	interstrand cross-link repair	7	37	3.18e-05
GO:BP	GO:0016321	female meiosis chromosome segregation	3	5	3.18e-05
GO:BP	GO:0007099	centriole replication	11	38	3.81e-05
GO:BP	GO:0034080	CENP-A containing chromatin assembly	6	7	4.24e-05
GO:BP	GO:0031055	chromatin remodeling at centromere	6	7	4.24e-05
GO:BP	GO:2000045	regulation of G1/S transition of mitotic cell cycle	17	146	4.24e-05
GO:BP	GO:0010032	meiotic chromosome condensation	5	6	4.44e-05
GO:BP	GO:0032886	regulation of microtubule-based process	14	217	5.52e-05
GO:BP	GO:0009411	response to UV	26	137	5.64e-05
GO:BP	GO:0007057	spindle assembly involved in female meiosis I	4	4	6.57e-05
GO:BP	GO:2000104	negative regulation of DNA-templated DNA replication	5	14	6.75e-05
GO:BP	GO:0031571	mitotic G1 DNA damage checkpoint signaling	9	27	6.77e-05
GO:BP	GO:0033314	mitotic DNA replication checkpoint signaling	5	9	7.62e-05
GO:BP	GO:0046605	regulation of centrosome cycle	12	51	7.89e-05
GO:BP	GO:1902806	regulation of cell cycle G1/S phase transition	18	166	8.92e-05
GO:BP	GO:0044819	mitotic G1/S transition checkpoint signaling	9	27	9.15e-05
GO:BP	GO:0098534	centriole assembly	11	41	9.55e-05
GO:BP	GO:0007292	female gamete generation	7	104	9.89e-05
GO:BP	GO:0045143	homologous chromosome segregation	13	33	9.89e-05
KEGG	KEGG:04110	Cell cycle	38	121	9.32e-23
KEGG	KEGG:03030	DNA replication	21	35	9.89e-18
KEGG	KEGG:04115	p53 signaling pathway	19	65	3.93e-12
KEGG	KEGG:03460	Fanconi anemia pathway	10	48	1.07e-07
KEGG	KEGG:03440	Homologous recombination	14	39	1.12e-07
KEGG	KEGG:03430	Mismatch repair	8	22	5.79e-06
KEGG	KEGG:04914	Progesterone-mediated oocyte maturation	12	86	1.24e-05
KEGG	KEGG:04114	Oocyte meiosis	12	108	1.50e-05
KEGG	KEGG:04218	Cellular senescence	15	145	7.97e-05

##Venn Diagrams

[1] 9294

[1] 774

Graphing GO of the Venn results

[1] 6129

##DDE response of 4400 (now 4911)

no significant enrichment found I did the intersection of all AC drugs and found a list that was 6129 genes long. Below is that analysis.

##DDEM response of 1218

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:1903047	mitotic cell cycle process	178	700	7.23e-35
GO:BP	GO:0000278	mitotic cell cycle	198	833	4.47e-34
GO:BP	GO:0022402	cell cycle process	232	1075	7.70e-31
GO:BP	GO:0007049	cell cycle	300	1522	1.90e-28
GO:BP	GO:0007059	chromosome segregation	115	378	6.58e-28
GO:BP	GO:0140014	mitotic nuclear division	84	264	1.28e-25
GO:BP	GO:0000070	mitotic sister chromatid segregation	69	193	1.86e-25
GO:BP	GO:0051276	chromosome organization	144	543	2.43e-25
GO:BP	GO:0000819	sister chromatid segregation	76	234	8.14e-25
GO:BP	GO:0010564	regulation of cell cycle process	142	620	1.35e-23
GO:BP	GO:0000280	nuclear division	103	354	2.37e-23
GO:BP	GO:0098813	nuclear chromosome segregation	93	287	6.34e-23
GO:BP	GO:0007093	mitotic cell cycle checkpoint signaling	56	136	5.99e-22
GO:BP	GO:0000075	cell cycle checkpoint signaling	65	180	9.99e-22
GO:BP	GO:0051301	cell division	122	567	2.45e-21
GO:BP	GO:0048285	organelle fission	104	397	1.40e-20
GO:BP	GO:0051726	regulation of cell cycle	192	950	1.95e-20
GO:BP	GO:0044770	cell cycle phase transition	116	499	2.57e-18
GO:BP	GO:0044772	mitotic cell cycle phase transition	100	413	5.84e-18
GO:BP	GO:0007346	regulation of mitotic cell cycle	105	438	2.27e-17
GO:BP	GO:0051983	regulation of chromosome segregation	46	118	3.07e-17
GO:BP	GO:0045930	negative regulation of mitotic cell cycle	65	208	3.09e-17
GO:BP	GO:0006260	DNA replication	74	258	5.31e-17
GO:BP	GO:1901988	negative regulation of cell cycle phase transition	67	232	5.40e-17
GO:BP	GO:1905818	regulation of chromosome separation	34	69	6.41e-17
GO:BP	GO:1901987	regulation of cell cycle phase transition	96	388	6.63e-17
GO:BP	GO:0010948	negative regulation of cell cycle process	73	270	1.00e-16
GO:BP	GO:0006261	DNA-templated DNA replication	53	149	1.12e-16
GO:BP	GO:1901990	regulation of mitotic cell cycle phase transition	79	305	6.03e-16
GO:BP	GO:0051304	chromosome separation	34	74	1.05e-15
GO:BP	GO:0045786	negative regulation of cell cycle	82	334	2.33e-15
GO:BP	GO:0007088	regulation of mitotic nuclear division	41	100	6.88e-15
GO:BP	GO:0010965	regulation of mitotic sister chromatid separation	29	58	7.65e-15
GO:BP	GO:0090068	positive regulation of cell cycle process	64	206	1.91e-14
GO:BP	GO:0033048	negative regulation of mitotic sister chromatid segregation	26	47	2.00e-14
GO:BP	GO:0033046	negative regulation of sister chromatid segregation	26	47	2.00e-14
GO:BP	GO:2000816	negative regulation of mitotic sister chromatid separation	26	47	2.00e-14
GO:BP	GO:1901991	negative regulation of mitotic cell cycle phase transition	52	163	2.93e-14
GO:BP	GO:0033047	regulation of mitotic sister chromatid segregation	27	52	3.04e-14
GO:BP	GO:0051306	mitotic sister chromatid separation	29	61	3.12e-14
GO:BP	GO:0006259	DNA metabolic process	170	890	3.78e-14
GO:BP	GO:0045839	negative regulation of mitotic nuclear division	27	54	5.00e-14
GO:BP	GO:0006974	cellular response to DNA damage stimulus	149	789	5.48e-14
GO:BP	GO:1905819	negative regulation of chromosome separation	26	48	5.61e-14
GO:BP	GO:0051985	negative regulation of chromosome segregation	26	48	5.61e-14
GO:BP	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	25	46	6.16e-14
GO:BP	GO:0051783	regulation of nuclear division	44	115	9.71e-14
GO:BP	GO:0033045	regulation of sister chromatid segregation	37	99	1.66e-13
GO:BP	GO:1902100	negative regulation of metaphase/anaphase transition of cell cycle	25	47	1.97e-13
GO:BP	GO:0071174	mitotic spindle checkpoint signaling	25	44	2.01e-13
GO:BP	GO:0071173	spindle assembly checkpoint signaling	25	44	2.01e-13
GO:BP	GO:0007094	mitotic spindle assembly checkpoint signaling	25	44	2.01e-13
GO:BP	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	34	91	2.01e-13
GO:BP	GO:0031577	spindle checkpoint signaling	24	45	3.74e-13
GO:BP	GO:0030071	regulation of mitotic metaphase/anaphase transition	33	88	4.65e-13
GO:BP	GO:0006281	DNA repair	109	535	5.29e-13
GO:BP	GO:0044784	metaphase/anaphase transition of cell cycle	34	92	5.43e-13
GO:BP	GO:0031570	DNA integrity checkpoint signaling	42	126	5.69e-13
GO:BP	GO:0007051	spindle organization	53	186	7.43e-13
GO:BP	GO:1902099	regulation of metaphase/anaphase transition of cell cycle	33	89	1.26e-12
GO:BP	GO:0051784	negative regulation of nuclear division	27	57	1.26e-12
GO:BP	GO:0033044	regulation of chromosome organization	58	233	2.26e-12
GO:BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	34	156	5.32e-12
GO:BP	GO:0007052	mitotic spindle organization	30	128	1.25e-11
GO:BP	GO:0008608	attachment of spindle microtubules to kinetochore	21	42	1.64e-11
GO:BP	GO:0045787	positive regulation of cell cycle	72	278	2.00e-11
GO:BP	GO:2001251	negative regulation of chromosome organization	32	90	2.07e-11
GO:BP	GO:0051225	spindle assembly	29	118	2.23e-11
GO:BP	GO:0044774	mitotic DNA integrity checkpoint signaling	31	82	3.43e-11
GO:BP	GO:0000077	DNA damage checkpoint signaling	36	118	9.12e-10
GO:BP	GO:1903046	meiotic cell cycle process	51	136	1.08e-09
GO:BP	GO:0042770	signal transduction in response to DNA damage	45	173	1.77e-09
GO:BP	GO:0000226	microtubule cytoskeleton organization	68	552	1.79e-09
GO:BP	GO:0044773	mitotic DNA damage checkpoint signaling	28	78	2.04e-09
GO:BP	GO:0044839	cell cycle G2/M phase transition	40	148	5.11e-09
GO:BP	GO:0032508	DNA duplex unwinding	28	75	6.57e-09
GO:BP	GO:0032392	DNA geometric change	29	81	8.17e-09
GO:BP	GO:0000086	G2/M transition of mitotic cell cycle	36	134	9.18e-09
GO:BP	GO:0071103	DNA conformation change	30	88	1.72e-08
GO:BP	GO:0006275	regulation of DNA replication	36	124	1.93e-08
GO:BP	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	11	18	2.16e-08
GO:BP	GO:0090329	regulation of DNA-templated DNA replication	21	54	2.90e-08
GO:BP	GO:0140013	meiotic nuclear division	45	121	3.16e-08
GO:BP	GO:0000281	mitotic cytokinesis	24	81	4.49e-08
GO:BP	GO:0050000	chromosome localization	22	82	7.43e-08
GO:BP	GO:0051984	positive regulation of chromosome segregation	14	25	7.72e-08
GO:BP	GO:0051255	spindle midzone assembly	9	12	7.88e-08
GO:BP	GO:0051231	spindle elongation	9	12	7.88e-08
GO:BP	GO:0051321	meiotic cell cycle	47	188	9.63e-08
GO:BP	GO:0032465	regulation of cytokinesis	22	79	9.78e-08
GO:BP	GO:0051310	metaphase plate congression	22	69	1.04e-07
GO:BP	GO:0007017	microtubule-based process	82	756	1.05e-07
GO:BP	GO:0006270	DNA replication initiation	17	35	1.08e-07
GO:BP	GO:0051256	mitotic spindle midzone assembly	8	9	1.52e-07
GO:BP	GO:0071459	protein localization to chromosome, centromeric region	18	42	1.66e-07
GO:BP	GO:0007080	mitotic metaphase plate congression	16	55	1.70e-07
GO:BP	GO:0034502	protein localization to chromosome	31	110	2.26e-07
GO:BP	GO:0010212	response to ionizing radiation	28	130	2.47e-07
GO:BP	GO:0000910	cytokinesis	36	163	3.11e-07
GO:BP	GO:1905820	positive regulation of chromosome separation	13	26	3.39e-07
GO:BP	GO:0051303	establishment of chromosome localization	23	75	4.05e-07
GO:BP	GO:0000022	mitotic spindle elongation	8	10	4.05e-07
GO:BP	GO:0051383	kinetochore organization	13	23	5.56e-07
GO:BP	GO:0034508	centromere complex assembly	15	30	5.86e-07
GO:BP	GO:0071478	cellular response to radiation	32	155	9.05e-07
GO:BP	GO:0010332	response to gamma radiation	15	50	9.52e-07
GO:BP	GO:0000076	DNA replication checkpoint signaling	11	15	1.07e-06
GO:BP	GO:0090307	mitotic spindle assembly	17	69	1.24e-06
GO:BP	GO:1903083	protein localization to condensed chromosome	11	18	1.38e-06
GO:BP	GO:0034501	protein localization to kinetochore	11	18	1.38e-06
GO:BP	GO:1901976	regulation of cell cycle checkpoint	17	45	1.77e-06
GO:BP	GO:0007098	centrosome cycle	32	126	2.10e-06
GO:BP	GO:0033260	nuclear DNA replication	16	35	2.19e-06
GO:BP	GO:0006268	DNA unwinding involved in DNA replication	11	22	2.48e-06
GO:BP	GO:0044786	cell cycle DNA replication	17	40	2.48e-06
GO:BP	GO:0045132	meiotic chromosome segregation	28	69	2.84e-06
GO:BP	GO:0033043	regulation of organelle organization	125	1023	3.05e-06
GO:BP	GO:0140694	non-membrane-bounded organelle assembly	54	355	3.19e-06
GO:BP	GO:0006541	glutamine metabolic process	4	23	3.19e-06
GO:BP	GO:0010389	regulation of G2/M transition of mitotic cell cycle	26	92	3.40e-06
GO:BP	GO:0009314	response to radiation	54	349	4.65e-06
GO:BP	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	9	13	5.23e-06
GO:BP	GO:1900262	regulation of DNA-directed DNA polymerase activity	9	13	5.23e-06
GO:BP	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	9	21	6.23e-06
GO:BP	GO:0045005	DNA-templated DNA replication maintenance of fidelity	19	50	6.58e-06
GO:BP	GO:1902749	regulation of cell cycle G2/M phase transition	27	102	8.28e-06
GO:BP	GO:0061640	cytoskeleton-dependent cytokinesis	23	103	9.69e-06
GO:BP	GO:0006302	double-strand break repair	50	270	9.90e-06
GO:BP	GO:0031023	microtubule organizing center organization	25	136	1.23e-05
GO:BP	GO:0006310	DNA recombination	56	256	1.57e-05
GO:BP	GO:0000725	recombinational repair	34	151	2.25e-05
GO:BP	GO:0061982	meiosis I cell cycle process	31	80	2.34e-05
GO:BP	GO:0051052	regulation of DNA metabolic process	81	459	2.37e-05
GO:BP	GO:1901992	positive regulation of mitotic cell cycle phase transition	22	86	3.11e-05
GO:BP	GO:0045931	positive regulation of mitotic cell cycle	26	113	3.56e-05
GO:BP	GO:0010639	negative regulation of organelle organization	45	318	3.87e-05
GO:BP	GO:0071897	DNA biosynthetic process	38	175	4.19e-05
GO:BP	GO:0006271	DNA strand elongation involved in DNA replication	9	15	4.55e-05
GO:BP	GO:1901989	positive regulation of cell cycle phase transition	26	103	7.27e-05
GO:BP	GO:0051302	regulation of cell division	27	144	7.35e-05
GO:BP	GO:0071214	cellular response to abiotic stimulus	41	264	7.94e-05
GO:BP	GO:1902969	mitotic DNA replication	8	14	7.94e-05
GO:BP	GO:0104004	cellular response to environmental stimulus	41	264	7.94e-05
GO:BP	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	7	12	8.20e-05
GO:BP	GO:0090232	positive regulation of spindle checkpoint	7	12	8.20e-05
GO:BP	GO:0071479	cellular response to ionizing radiation	17	68	8.85e-05
GO:BP	GO:0000724	double-strand break repair via homologous recombination	32	147	1.03e-04
GO:BP	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	15	43	1.04e-04
GO:BP	GO:0009411	response to UV	24	137	1.13e-04
GO:BP	GO:0033554	cellular response to stress	206	1677	1.19e-04
GO:BP	GO:1903504	regulation of mitotic spindle checkpoint	9	19	1.29e-04
GO:BP	GO:0090231	regulation of spindle checkpoint	9	19	1.29e-04
GO:BP	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore	6	11	1.29e-04
GO:BP	GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint	9	19	1.29e-04
GO:BP	GO:0032467	positive regulation of cytokinesis	13	33	1.40e-04
GO:BP	GO:0065004	protein-DNA complex assembly	44	185	1.51e-04
GO:BP	GO:0000727	double-strand break repair via break-induced replication	7	11	1.59e-04
GO:BP	GO:0071480	cellular response to gamma radiation	9	29	1.64e-04
GO:BP	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	21	76	1.94e-04
GO:BP	GO:0007127	meiosis I	28	76	2.29e-04
GO:BP	GO:0034644	cellular response to UV	16	83	2.46e-04
GO:BP	GO:0009064	glutamine family amino acid metabolic process	4	61	2.59e-04
GO:BP	GO:1903490	positive regulation of mitotic cytokinesis	5	7	2.85e-04
GO:BP	GO:1901978	positive regulation of cell cycle checkpoint	8	19	2.95e-04
GO:BP	GO:0007062	sister chromatid cohesion	16	51	3.15e-04
GO:BP	GO:1902425	positive regulation of attachment of mitotic spindle microtubules to kinetochore	5	8	3.57e-04
GO:BP	GO:0044818	mitotic G2/M transition checkpoint	15	50	3.57e-04
GO:BP	GO:1902423	regulation of attachment of mitotic spindle microtubules to kinetochore	5	8	3.57e-04
GO:BP	GO:0072331	signal transduction by p53 class mediator	30	160	3.67e-04
GO:BP	GO:0000731	DNA synthesis involved in DNA repair	13	36	4.18e-04
GO:BP	GO:0008315	G2/MI transition of meiotic cell cycle	5	5	4.20e-04
GO:BP	GO:1901970	positive regulation of mitotic sister chromatid separation	8	18	4.98e-04
GO:BP	GO:0071824	protein-DNA complex subunit organization	45	204	5.17e-04
GO:BP	GO:0006996	organelle organization	323	2971	5.78e-04
GO:BP	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	8	15	6.09e-04
GO:BP	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	24	87	6.16e-04
GO:BP	GO:1905832	positive regulation of spindle assembly	5	7	6.43e-04
GO:BP	GO:0042148	strand invasion	5	5	6.76e-04
GO:BP	GO:0007076	mitotic chromosome condensation	8	19	6.76e-04
GO:BP	GO:0046601	positive regulation of centriole replication	5	9	7.06e-04
GO:BP	GO:0051656	establishment of organelle localization	52	375	7.34e-04
GO:BP	GO:0030174	regulation of DNA-templated DNA replication initiation	7	14	7.53e-04
GO:BP	GO:0060236	regulation of mitotic spindle organization	10	42	7.57e-04
GO:BP	GO:0090235	regulation of metaphase plate congression	6	13	7.87e-04
GO:BP	GO:0035825	homologous recombination	17	43	8.53e-04
GO:BP	GO:0090224	regulation of spindle organization	11	45	9.15e-04
GO:BP	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	13	60	9.15e-04
GO:BP	GO:1904029	regulation of cyclin-dependent protein kinase activity	24	90	9.15e-04
GO:BP	GO:0031297	replication fork processing	14	42	1.12e-03
GO:BP	GO:0033314	mitotic DNA replication checkpoint signaling	6	9	1.24e-03
GO:BP	GO:1902750	negative regulation of cell cycle G2/M phase transition	13	62	1.27e-03
GO:BP	GO:0010032	meiotic chromosome condensation	4	6	1.27e-03
GO:BP	GO:0070192	chromosome organization involved in meiotic cell cycle	18	44	1.35e-03
GO:BP	GO:1905821	positive regulation of chromosome condensation	4	5	1.49e-03
GO:BP	GO:0031571	mitotic G1 DNA damage checkpoint signaling	10	27	1.49e-03
GO:BP	GO:0085020	protein K6-linked ubiquitination	5	9	1.52e-03
GO:BP	GO:0044771	meiotic cell cycle phase transition	6	7	1.53e-03
GO:BP	GO:0036297	interstrand cross-link repair	11	37	1.58e-03
GO:BP	GO:0051640	organelle localization	62	498	1.66e-03
GO:BP	GO:0019346	transsulfuration	4	5	1.90e-03
GO:BP	GO:0009092	homoserine metabolic process	4	5	1.90e-03
GO:BP	GO:0030330	DNA damage response, signal transduction by p53 class mediator	7	68	1.92e-03
GO:BP	GO:0044819	mitotic G1/S transition checkpoint signaling	10	27	1.99e-03
GO:BP	GO:0007095	mitotic G2 DNA damage checkpoint signaling	10	35	2.03e-03
GO:BP	GO:1904666	regulation of ubiquitin protein ligase activity	8	24	2.33e-03
GO:BP	GO:1902412	regulation of mitotic cytokinesis	5	8	2.38e-03
GO:BP	GO:0051382	kinetochore assembly	8	18	2.43e-03
GO:BP	GO:0086067	AV node cell to bundle of His cell communication	6	11	2.51e-03
GO:BP	GO:0010638	positive regulation of organelle organization	57	432	2.61e-03
GO:BP	GO:0071168	protein localization to chromatin	10	49	2.69e-03
GO:BP	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	6	16	3.15e-03
GO:BP	GO:0044806	G-quadruplex DNA unwinding	5	7	3.15e-03
GO:BP	GO:1902751	positive regulation of cell cycle G2/M phase transition	10	30	3.89e-03
GO:BP	GO:0007143	female meiotic nuclear division	10	25	3.94e-03
GO:BP	GO:0006513	protein monoubiquitination	14	83	3.97e-03
GO:BP	GO:0046599	regulation of centriole replication	7	21	4.10e-03
GO:BP	GO:0009263	deoxyribonucleotide biosynthetic process	7	15	4.19e-03
GO:BP	GO:0009265	2’-deoxyribonucleotide biosynthetic process	7	15	4.19e-03
GO:BP	GO:0046385	deoxyribose phosphate biosynthetic process	7	15	4.19e-03
GO:BP	GO:0061644	protein localization to CENP-A containing chromatin	5	17	4.73e-03
GO:BP	GO:0040001	establishment of mitotic spindle localization	10	36	5.81e-03
GO:BP	GO:0030261	chromosome condensation	11	34	6.28e-03
GO:BP	GO:1903925	response to bisphenol A	3	4	6.46e-03
GO:BP	GO:1903926	cellular response to bisphenol A	3	4	6.46e-03
GO:BP	GO:0022616	DNA strand elongation	11	35	6.89e-03
GO:BP	GO:1902315	nuclear cell cycle DNA replication initiation	3	5	6.90e-03
GO:BP	GO:1902975	mitotic DNA replication initiation	3	5	6.90e-03
GO:BP	GO:1902292	cell cycle DNA replication initiation	3	5	6.90e-03
GO:BP	GO:0051298	centrosome duplication	16	68	6.93e-03
GO:BP	GO:0071482	cellular response to light stimulus	17	96	7.72e-03
GO:BP	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	9	27	8.17e-03
GO:BP	GO:1901605	alpha-amino acid metabolic process	4	161	8.31e-03
GO:BP	GO:0090169	regulation of spindle assembly	8	32	8.48e-03
GO:BP	GO:0007099	centriole replication	9	38	8.48e-03
GO:BP	GO:1904668	positive regulation of ubiquitin protein ligase activity	5	11	8.52e-03
GO:BP	GO:0008156	negative regulation of DNA replication	9	26	8.83e-03
GO:BP	GO:0140527	reciprocal homologous recombination	14	36	8.83e-03
GO:BP	GO:0007131	reciprocal meiotic recombination	14	36	8.83e-03
GO:BP	GO:0086016	AV node cell action potential	5	9	9.23e-03
GO:BP	GO:0086027	AV node cell to bundle of His cell signaling	5	9	9.23e-03
GO:BP	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	21	94	9.85e-03
GO:BP	GO:0006334	nucleosome assembly	15	80	9.96e-03
GO:BP	GO:0006301	postreplication repair	8	34	1.07e-02
GO:BP	GO:0110032	positive regulation of G2/MI transition of meiotic cell cycle	3	3	1.07e-02
GO:BP	GO:2000001	regulation of DNA damage checkpoint	7	25	1.09e-02
GO:BP	GO:0051053	negative regulation of DNA metabolic process	24	118	1.12e-02
GO:BP	GO:0010824	regulation of centrosome duplication	10	44	1.12e-02
GO:BP	GO:0007064	mitotic sister chromatid cohesion	9	29	1.12e-02
GO:BP	GO:0051653	spindle localization	12	52	1.14e-02
GO:BP	GO:0009084	glutamine family amino acid biosynthetic process	2	17	1.16e-02
GO:BP	GO:0000132	establishment of mitotic spindle orientation	7	31	1.16e-02
GO:BP	GO:0006167	AMP biosynthetic process	2	14	1.18e-02
GO:BP	GO:2000104	negative regulation of DNA-templated DNA replication	6	14	1.21e-02
GO:BP	GO:0070925	organelle assembly	40	803	1.27e-02
GO:BP	GO:1990227	paranodal junction maintenance	1	2	1.31e-02
GO:BP	GO:0006177	GMP biosynthetic process	2	14	1.34e-02
GO:BP	GO:0046602	regulation of mitotic centrosome separation	4	8	1.41e-02
GO:BP	GO:0016446	somatic hypermutation of immunoglobulin genes	5	11	1.44e-02
GO:BP	GO:0007089	traversing start control point of mitotic cell cycle	3	4	1.46e-02
GO:BP	GO:0071496	cellular response to external stimulus	9	268	1.49e-02
GO:BP	GO:0006312	mitotic recombination	8	23	1.49e-02
GO:BP	GO:0006290	pyrimidine dimer repair	1	7	1.49e-02
GO:BP	GO:0072719	cellular response to cisplatin	3	4	1.54e-02
GO:BP	GO:0098534	centriole assembly	9	41	1.54e-02
GO:BP	GO:0034728	nucleosome organization	16	98	1.55e-02
GO:BP	GO:1902117	positive regulation of organelle assembly	6	75	1.65e-02
GO:BP	GO:0007057	spindle assembly involved in female meiosis I	3	4	1.69e-02
GO:BP	GO:0000302	response to reactive oxygen species	11	160	1.70e-02
GO:BP	GO:0051445	regulation of meiotic cell cycle	13	45	1.81e-02
GO:BP	GO:0009440	cyanate catabolic process	2	2	1.86e-02
GO:BP	GO:0009439	cyanate metabolic process	2	2	1.86e-02
GO:BP	GO:0051293	establishment of spindle localization	11	48	1.88e-02
GO:BP	GO:1902115	regulation of organelle assembly	10	186	1.90e-02
GO:BP	GO:0048368	lateral mesoderm development	2	10	1.93e-02
GO:BP	GO:0016321	female meiosis chromosome segregation	3	5	2.03e-02
GO:BP	GO:0002566	somatic diversification of immune receptors via somatic mutation	5	12	2.07e-02
GO:BP	GO:0007010	cytoskeleton organization	86	1222	2.11e-02
GO:BP	GO:0019985	translesion synthesis	6	24	2.16e-02
GO:BP	GO:0051294	establishment of spindle orientation	9	36	2.16e-02
GO:BP	GO:0060623	regulation of chromosome condensation	4	9	2.19e-02
GO:BP	GO:0090306	meiotic spindle assembly	4	8	2.27e-02
GO:BP	GO:0032506	cytokinetic process	8	39	2.31e-02
GO:BP	GO:0006298	mismatch repair	8	29	2.37e-02
GO:BP	GO:0099607	lateral attachment of mitotic spindle microtubules to kinetochore	2	2	2.37e-02
GO:BP	GO:0051438	regulation of ubiquitin-protein transferase activity	9	53	2.44e-02
GO:BP	GO:0070914	UV-damage excision repair	1	13	2.50e-02
GO:BP	GO:0032886	regulation of microtubule-based process	11	217	2.50e-02
GO:BP	GO:0086066	atrial cardiac muscle cell to AV node cell communication	6	17	2.50e-02
GO:BP	GO:0086014	atrial cardiac muscle cell action potential	6	17	2.50e-02
GO:BP	GO:0086026	atrial cardiac muscle cell to AV node cell signaling	6	17	2.50e-02
GO:BP	GO:2000573	positive regulation of DNA biosynthetic process	15	67	2.50e-02
GO:BP	GO:0006520	amino acid metabolic process	4	234	2.50e-02
GO:BP	GO:1905340	regulation of protein localization to kinetochore	3	4	2.60e-02
GO:BP	GO:1905342	positive regulation of protein localization to kinetochore	3	4	2.60e-02
GO:BP	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	13	99	2.61e-02
GO:BP	GO:0044210	‘de novo’ CTP biosynthetic process	1	2	2.63e-02
GO:BP	GO:0090656	t-circle formation	6	13	2.67e-02
GO:BP	GO:0090737	telomere maintenance via telomere trimming	6	13	2.67e-02
GO:BP	GO:0001325	formation of extrachromosomal circular DNA	6	13	2.67e-02
GO:BP	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	2	22	2.73e-02
GO:BP	GO:1901751	leukotriene A4 metabolic process	2	2	2.85e-02
GO:BP	GO:0003283	atrial septum development	5	23	2.90e-02
GO:BP	GO:0046605	regulation of centrosome cycle	10	51	2.90e-02
GO:BP	GO:2000278	regulation of DNA biosynthetic process	21	111	2.97e-02
GO:BP	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	6	17	3.08e-02
GO:BP	GO:0035611	protein branching point deglutamylation	1	1	3.08e-02
GO:BP	GO:0098910	regulation of atrial cardiac muscle cell action potential	3	4	3.08e-02
GO:BP	GO:0051446	positive regulation of meiotic cell cycle	7	15	3.11e-02
GO:BP	GO:0007100	mitotic centrosome separation	5	13	3.11e-02
GO:BP	GO:0008340	determination of adult lifespan	7	16	3.11e-02
GO:BP	GO:0009127	purine nucleoside monophosphate biosynthetic process	2	24	3.11e-02
GO:BP	GO:0046033	AMP metabolic process	2	22	3.11e-02
GO:BP	GO:0072718	response to cisplatin	3	5	3.11e-02
GO:BP	GO:0110030	regulation of G2/MI transition of meiotic cell cycle	3	3	3.13e-02
GO:BP	GO:1901995	positive regulation of meiotic cell cycle phase transition	3	3	3.13e-02
GO:BP	GO:0051782	negative regulation of cell division	5	15	3.13e-02
GO:BP	GO:2001055	positive regulation of mesenchymal cell apoptotic process	1	2	3.14e-02
GO:BP	GO:0035880	embryonic nail plate morphogenesis	1	3	3.14e-02
GO:BP	GO:0051795	positive regulation of timing of catagen	1	3	3.14e-02
GO:BP	GO:0051785	positive regulation of nuclear division	11	37	3.21e-02
GO:BP	GO:0097294	‘de novo’ XMP biosynthetic process	3	7	3.21e-02
GO:BP	GO:0097292	XMP metabolic process	3	7	3.21e-02
GO:BP	GO:0097293	XMP biosynthetic process	3	7	3.21e-02
GO:BP	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process	5	10	3.27e-02
GO:BP	GO:0034080	CENP-A containing chromatin assembly	4	7	3.27e-02
GO:BP	GO:0031055	chromatin remodeling at centromere	4	7	3.27e-02
GO:BP	GO:0046037	GMP metabolic process	3	24	3.29e-02
GO:BP	GO:0000212	meiotic spindle organization	5	14	3.31e-02
GO:BP	GO:0019276	UDP-N-acetylgalactosamine metabolic process	2	2	3.31e-02
GO:BP	GO:0000912	assembly of actomyosin apparatus involved in cytokinesis	3	6	3.31e-02
GO:BP	GO:0002076	osteoblast development	2	12	3.31e-02
GO:BP	GO:0000915	actomyosin contractile ring assembly	3	6	3.31e-02
GO:BP	GO:0010825	positive regulation of centrosome duplication	1	4	3.33e-02
GO:BP	GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance	6	16	3.33e-02
GO:BP	GO:0051054	positive regulation of DNA metabolic process	34	261	3.38e-02
GO:BP	GO:0086064	cell communication by electrical coupling involved in cardiac conduction	7	26	3.40e-02
GO:BP	GO:0099068	postsynapse assembly	5	23	3.43e-02
GO:BP	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	7	22	3.56e-02
GO:BP	GO:0030510	regulation of BMP signaling pathway	2	84	3.57e-02
GO:BP	GO:0051129	negative regulation of cellular component organization	73	586	3.57e-02
GO:BP	GO:1902010	negative regulation of translation in response to endoplasmic reticulum stress	1	1	3.59e-02
GO:BP	GO:0007144	female meiosis I	5	9	3.64e-02
GO:BP	GO:0023019	signal transduction involved in regulation of gene expression	2	14	3.66e-02
GO:BP	GO:0048818	positive regulation of hair follicle maturation	2	5	3.66e-02
GO:BP	GO:0035518	histone H2A monoubiquitination	1	23	3.71e-02
GO:BP	GO:0009991	response to extracellular stimulus	19	372	3.73e-02
GO:BP	GO:0042772	DNA damage response, signal transduction resulting in transcription	6	18	3.73e-02
GO:BP	GO:0031331	positive regulation of cellular catabolic process	16	373	3.73e-02
GO:BP	GO:0072711	cellular response to hydroxyurea	4	10	3.78e-02
GO:BP	GO:0060364	frontal suture morphogenesis	1	4	3.78e-02
GO:BP	GO:1903416	response to glycoside	3	6	3.78e-02
GO:BP	GO:0042637	catagen	1	4	3.78e-02
GO:BP	GO:0051794	regulation of timing of catagen	1	4	3.78e-02
GO:BP	GO:0035973	aggrephagy	2	8	3.78e-02
GO:BP	GO:0033209	tumor necrosis factor-mediated signaling pathway	4	77	3.78e-02
GO:BP	GO:0000082	G1/S transition of mitotic cell cycle	32	203	3.82e-02
GO:BP	GO:0009267	cellular response to starvation	9	151	3.83e-02
GO:BP	GO:0051299	centrosome separation	5	14	3.87e-02
GO:BP	GO:1903724	positive regulation of centriole elongation	1	5	3.87e-02
GO:BP	GO:0006979	response to oxidative stress	17	349	3.87e-02
GO:BP	GO:0003230	cardiac atrium development	6	34	3.97e-02
GO:BP	GO:0086001	cardiac muscle cell action potential	14	68	4.06e-02
GO:BP	GO:0002227	innate immune response in mucosa	4	8	4.06e-02
GO:BP	GO:0051754	meiotic sister chromatid cohesion, centromeric	3	4	4.10e-02
GO:BP	GO:0009394	2’-deoxyribonucleotide metabolic process	10	37	4.20e-02
GO:BP	GO:0031667	response to nutrient levels	18	348	4.33e-02
GO:BP	GO:0006189	‘de novo’ IMP biosynthetic process	3	8	4.37e-02
GO:BP	GO:0006175	dATP biosynthetic process	1	1	4.37e-02
GO:BP	GO:0044208	‘de novo’ AMP biosynthetic process	3	8	4.37e-02
GO:BP	GO:0045143	homologous chromosome segregation	13	33	4.44e-02
GO:BP	GO:0009628	response to abiotic stimulus	84	862	4.44e-02
GO:BP	GO:0090427	activation of meiosis	1	3	4.48e-02
GO:BP	GO:0051781	positive regulation of cell division	14	64	4.49e-02
GO:BP	GO:0055001	muscle cell development	27	164	4.52e-02
GO:BP	GO:1901993	regulation of meiotic cell cycle phase transition	4	5	4.58e-02
GO:BP	GO:0045870	positive regulation of single stranded viral RNA replication via double stranded DNA intermediate	2	2	4.58e-02
GO:BP	GO:0033522	histone H2A ubiquitination	1	32	4.72e-02
GO:BP	GO:0009112	nucleobase metabolic process	2	27	4.73e-02
GO:BP	GO:0009262	deoxyribonucleotide metabolic process	10	38	4.83e-02
GO:BP	GO:0019692	deoxyribose phosphate metabolic process	10	38	4.83e-02
GO:BP	GO:0043928	exonucleolytic catabolism of deadenylated mRNA	2	13	4.83e-02
GO:BP	GO:0044837	actomyosin contractile ring organization	3	7	4.88e-02
GO:BP	GO:0060013	righting reflex	3	6	4.93e-02
KEGG	KEGG:04110	Cell cycle	40	121	1.33e-11
KEGG	KEGG:03030	DNA replication	18	35	2.14e-08
KEGG	KEGG:04115	p53 signaling pathway	25	65	8.12e-08
KEGG	KEGG:03440	Homologous recombination	11	39	4.13e-04
KEGG	KEGG:03430	Mismatch repair	9	22	1.23e-03
KEGG	KEGG:05034	Alcoholism	24	122	5.88e-03
KEGG	KEGG:03460	Fanconi anemia pathway	13	48	5.88e-03
KEGG	KEGG:05322	Systemic lupus erythematosus	5	61	5.88e-03
KEGG	KEGG:04114	Oocyte meiosis	23	108	1.09e-02
KEGG	KEGG:04217	Necroptosis	5	106	1.12e-02
KEGG	KEGG:04914	Progesterone-mediated oocyte maturation	19	86	1.12e-02
KEGG	KEGG:01524	Platinum drug resistance	12	65	1.33e-02
KEGG	KEGG:03420	Nucleotide excision repair	11	43	1.33e-02
KEGG	KEGG:04964	Proximal tubule bicarbonate reclamation	2	20	1.33e-02
KEGG	KEGG:04613	Neutrophil extracellular trap formation	5	110	1.66e-02
KEGG	KEGG:05212	Pancreatic cancer	4	75	1.96e-02
KEGG	KEGG:03410	Base excision repair	6	33	2.77e-02
KEGG	KEGG:04210	Apoptosis	15	118	3.23e-02
KEGG	KEGG:05216	Thyroid cancer	1	35	4.54e-02

##dauno sp response 3 hour

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	137	1915	6.69e-09
GO:BP	GO:0006366	transcription by RNA polymerase II	140	1991	6.69e-09
GO:BP	GO:0006351	DNA-templated transcription	160	2683	1.69e-08
GO:BP	GO:0097659	nucleic acid-templated transcription	160	2684	1.69e-08
GO:BP	GO:0006355	regulation of DNA-templated transcription	158	2579	2.30e-08
GO:BP	GO:1903506	regulation of nucleic acid-templated transcription	158	2581	2.30e-08
GO:BP	GO:0032774	RNA biosynthetic process	160	2714	2.30e-08
GO:BP	GO:2001141	regulation of RNA biosynthetic process	158	2598	3.32e-08
GO:BP	GO:0051252	regulation of RNA metabolic process	129	2849	3.56e-08
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	135	3105	9.46e-08
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	130	3015	3.83e-07
GO:BP	GO:0031326	regulation of cellular biosynthetic process	131	3123	2.55e-06
GO:BP	GO:0009889	regulation of biosynthetic process	131	3174	6.85e-06
GO:BP	GO:0018130	heterocycle biosynthetic process	129	3148	1.34e-05
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	127	3083	1.45e-05
GO:BP	GO:0019438	aromatic compound biosynthetic process	128	3149	2.72e-05
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	131	3253	3.16e-05
GO:BP	GO:0009059	macromolecule biosynthetic process	142	3730	4.15e-05
GO:BP	GO:0031323	regulation of cellular metabolic process	157	4305	2.47e-04
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	139	3758	5.77e-04
GO:BP	GO:0044249	cellular biosynthetic process	158	4465	7.01e-04
GO:BP	GO:0140467	integrated stress response signaling	5	34	1.09e-03
GO:BP	GO:1901576	organic substance biosynthetic process	159	4537	1.09e-03
GO:BP	GO:1903508	positive regulation of nucleic acid-templated transcription	83	1304	1.09e-03
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	83	1304	1.09e-03
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	83	1311	1.23e-03
GO:BP	GO:0009058	biosynthetic process	159	4595	2.52e-03
GO:BP	GO:0051254	positive regulation of RNA metabolic process	86	1431	3.44e-03
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	89	1499	3.69e-03
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	88	1571	5.40e-03
GO:BP	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	3	18	7.29e-03
GO:BP	GO:0080090	regulation of primary metabolic process	217	4440	1.03e-02
GO:BP	GO:0009891	positive regulation of biosynthetic process	88	1598	1.03e-02
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	61	925	1.37e-02
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	211	4330	1.51e-02
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	90	1600	1.65e-02
GO:BP	GO:2000121	regulation of removal of superoxide radicals	2	6	2.35e-02
GO:BP	GO:0036499	PERK-mediated unfolded protein response	3	17	2.40e-02
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	36	735	4.04e-02
GO:BP	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	3	39	4.65e-02
GO:BP	GO:0051253	negative regulation of RNA metabolic process	43	1115	4.89e-02
KEGG	KEGG:05168	Herpes simplex virus 1 infection	44	415	5.92e-08

DXspecific response (only the subset unique to Dox)

Whoa! look at the calcium things

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	3	23	1.56e-02
GO:BP	GO:2001257	regulation of cation channel activity	4	98	3.23e-02
GO:BP	GO:2001258	negative regulation of cation channel activity	3	30	3.23e-02
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	2	141	4.68e-02
GO:BP	GO:0032410	negative regulation of transporter activity	3	58	4.68e-02
GO:BP	GO:0032413	negative regulation of ion transmembrane transporter activity	3	51	4.68e-02
GO:BP	GO:0034763	negative regulation of transmembrane transport	4	95	4.68e-02
GO:BP	GO:0051279	regulation of release of sequestered calcium ion into cytosol	3	60	4.68e-02
GO:BP	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol	2	11	4.68e-02
GO:BP	GO:0051284	positive regulation of sequestering of calcium ion	2	13	4.68e-02
GO:BP	GO:0051342	regulation of cyclic-nucleotide phosphodiesterase activity	2	10	4.68e-02
GO:BP	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	2	10	4.68e-02
GO:BP	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	2	9	4.68e-02
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	2	116	4.68e-02
GO:BP	GO:1901019	regulation of calcium ion transmembrane transporter activity	3	71	4.68e-02
GO:BP	GO:1904063	negative regulation of cation transmembrane transport	3	64	4.68e-02

##No Response genes n=4593 Genes shows a little enrichment. Higher than Doxorubicin specific

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0045229	external encapsulating structure organization	108	231	3.93e-03
GO:BP	GO:0042775	mitochondrial ATP synthesis coupled electron transport	47	82	3.93e-03
GO:BP	GO:0002181	cytoplasmic translation	79	155	3.93e-03
GO:BP	GO:0010466	negative regulation of peptidase activity	75	149	3.93e-03
GO:BP	GO:0030198	extracellular matrix organization	107	230	3.93e-03
GO:BP	GO:0042773	ATP synthesis coupled electron transport	47	82	3.93e-03
GO:BP	GO:0019646	aerobic electron transport chain	44	74	3.93e-03
GO:BP	GO:0043062	extracellular structure organization	107	231	4.34e-03
GO:BP	GO:0010951	negative regulation of endopeptidase activity	72	143	4.34e-03
GO:BP	GO:0022904	respiratory electron transport chain	55	103	5.78e-03
GO:BP	GO:0006812	monoatomic cation transport	266	668	7.19e-03
GO:BP	GO:0006119	oxidative phosphorylation	67	134	9.45e-03
GO:BP	GO:0098655	monoatomic cation transmembrane transport	218	541	1.56e-02
GO:BP	GO:0052548	regulation of endopeptidase activity	120	273	1.56e-02
GO:BP	GO:0009100	glycoprotein metabolic process	136	317	1.77e-02
GO:BP	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	11	12	2.10e-02
GO:BP	GO:0006811	monoatomic ion transport	299	774	2.15e-02
GO:BP	GO:0045861	negative regulation of proteolysis	100	223	2.15e-02
GO:BP	GO:0055085	transmembrane transport	375	996	2.78e-02
GO:BP	GO:0052547	regulation of peptidase activity	127	297	2.92e-02
GO:BP	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen	13	16	3.76e-02
GO:BP	GO:0034220	monoatomic ion transmembrane transport	247	633	3.83e-02
GO:BP	GO:0009060	aerobic respiration	82	180	4.08e-02
GO:BP	GO:0098662	inorganic cation transmembrane transport	207	521	4.08e-02
KEGG	KEGG:05171	Coronavirus disease - COVID-19	93	162	6.25e-09
KEGG	KEGG:03010	Ribosome	75	127	4.57e-08
KEGG	KEGG:04510	Focal adhesion	86	175	1.77e-04
KEGG	KEGG:00190	Oxidative phosphorylation	56	106	5.72e-04
KEGG	KEGG:05415	Diabetic cardiomyopathy	81	169	7.09e-04
KEGG	KEGG:04512	ECM-receptor interaction	39	69	1.24e-03
KEGG	KEGG:04714	Thermogenesis	89	195	2.05e-03
KEGG	KEGG:05012	Parkinson disease	100	226	2.24e-03
KEGG	KEGG:04260	Cardiac muscle contraction	37	67	2.24e-03
KEGG	KEGG:00531	Glycosaminoglycan degradation	13	16	2.24e-03
KEGG	KEGG:05208	Chemical carcinogenesis - reactive oxygen species	85	186	2.24e-03
KEGG	KEGG:05020	Prion disease	97	220	2.89e-03
KEGG	KEGG:04066	HIF-1 signaling pathway	45	89	5.34e-03
KEGG	KEGG:04810	Regulation of actin cytoskeleton	80	179	5.72e-03
KEGG	KEGG:04932	Non-alcoholic fatty liver disease	61	131	7.58e-03
KEGG	KEGG:04141	Protein processing in endoplasmic reticulum	72	161	9.80e-03
KEGG	KEGG:04151	PI3K-Akt signaling pathway	106	254	1.26e-02
KEGG	KEGG:01200	Carbon metabolism	47	98	1.32e-02
KEGG	KEGG:00000	KEGG root term	1855	5534	1.40e-02
KEGG	KEGG:04926	Relaxin signaling pathway	49	104	1.45e-02
KEGG	KEGG:05146	Amoebiasis	33	64	1.45e-02
KEGG	KEGG:05168	Herpes simplex virus 1 infection	161	415	2.70e-02
KEGG	KEGG:04270	Vascular smooth muscle contraction	44	94	2.78e-02
KEGG	KEGG:00511	Other glycan degradation	11	16	4.04e-02

##GO:BP full figure DEG analysis

    source    term_id
1    GO:BP GO:0007059
2    GO:BP GO:0000278
3    GO:BP GO:0000070
4    GO:BP GO:0000819
5    GO:BP GO:0140014
6    GO:BP GO:1903047
7    GO:BP GO:0010564
8    GO:BP GO:0051301
9    GO:BP GO:0051726
10   GO:BP GO:0098813
11   GO:BP GO:0022402
12   GO:BP GO:0007093
13   GO:BP GO:0000075
14   GO:BP GO:0051276
15   GO:BP GO:0007049
16   GO:BP GO:0000280
17   GO:BP GO:0045930
18   GO:BP GO:0045786
19   GO:BP GO:0048285
20   GO:BP GO:0010948
21   GO:BP GO:0008608
22   GO:BP GO:0007051
23   GO:BP GO:0006974
24   GO:BP GO:1902850
25   GO:BP GO:0051225
26   GO:BP GO:1905818
27   GO:BP GO:1901988
28   GO:BP GO:0007052
29   GO:BP GO:0051983
30   GO:BP GO:0006281
31   GO:BP GO:0071173
32   GO:BP GO:0007094
33   GO:BP GO:0071174
34   GO:BP GO:0007346
35   GO:BP GO:0051304
36   GO:BP GO:0031577
37   GO:BP GO:0007080
38   GO:BP GO:0045839
39   GO:BP GO:0045841
40   GO:BP GO:0010965
41   GO:BP GO:0033047
42   GO:BP GO:0006261
43   GO:BP GO:2001251
44   GO:BP GO:0031570
45   GO:BP GO:0007088
46   GO:BP GO:0033048
47   GO:BP GO:2000816
48   GO:BP GO:0033046
49   GO:BP GO:1902100
50   GO:BP GO:0051310
51   GO:BP GO:1901987
52   GO:BP GO:0006541
53   GO:BP GO:0030071
54   GO:BP GO:0006260
55   GO:BP GO:0051306
56   GO:BP GO:0007091
57   GO:BP GO:0051988
58   GO:BP GO:0051783
59   GO:BP GO:1905819
60   GO:BP GO:1901991
61   GO:BP GO:0051985
62   GO:BP GO:0090068
63   GO:BP GO:0044774
64   GO:BP GO:0032465
65   GO:BP GO:1902099
66   GO:BP GO:0051984
67   GO:BP GO:0051784
68   GO:BP GO:0044784
69   GO:BP GO:0051231
70   GO:BP GO:0033045
71   GO:BP GO:0010639
72   GO:BP GO:0044770
73   GO:BP GO:0051256
74   GO:BP GO:1901990
75   GO:BP GO:0051255
76   GO:BP GO:0051303
77   GO:BP GO:0090307
78   GO:BP GO:0006270
79   GO:BP GO:0044773
80   GO:BP GO:0000226
81   GO:BP GO:0000077
82   GO:BP GO:0044772
83   GO:BP GO:0042770
84   GO:BP GO:0033044
85   GO:BP GO:0000022
86   GO:BP GO:0019985
87   GO:BP GO:0050000
88   GO:BP GO:0006301
89   GO:BP GO:0033043
90   GO:BP GO:0010389
91   GO:BP GO:0000731
92   GO:BP GO:0000281
93   GO:BP GO:0000086
94   GO:BP GO:0010212
95   GO:BP GO:0006275
96   GO:BP GO:0051383
97   GO:BP GO:0000910
98   GO:BP GO:0051302
99   GO:BP GO:0051315
100  GO:BP GO:0006167
101  GO:BP GO:0006271
102  GO:BP GO:0060236
103  GO:BP GO:0090329
104  GO:BP GO:0044839
105  GO:BP GO:0006177
106  GO:BP GO:0009411
107  GO:BP GO:0044818
108  GO:BP GO:1903490
109  GO:BP GO:0090224
110  GO:BP GO:0046060
111  GO:BP GO:0032508
112  GO:BP GO:0009064
113  GO:BP GO:0006259
114  GO:BP GO:1902412
115  GO:BP GO:1905820
116  GO:BP GO:0007098
117  GO:BP GO:1902749
118  GO:BP GO:0061640
119  GO:BP GO:0036166
120  GO:BP GO:0060623
121  GO:BP GO:0010972
122  GO:BP GO:0030330
123  GO:BP GO:1901976
124  GO:BP GO:0045005
125  GO:BP GO:0009168
126  GO:BP GO:0046602
127  GO:BP GO:0009127
128  GO:BP GO:0046033
129  GO:BP GO:0051987
130  GO:BP GO:0045787
131  GO:BP GO:0031023
132  GO:BP GO:1902750
133  GO:BP GO:0032263
134  GO:BP GO:0044209
135  GO:BP GO:0007095
136  GO:BP GO:1902969
137  GO:BP GO:1902425
138  GO:BP GO:1902423
139  GO:BP GO:1903046
140  GO:BP GO:0046037
141  GO:BP GO:0044786
142  GO:BP GO:0032392
143  GO:BP GO:0046112
144  GO:BP GO:0007017
145  GO:BP GO:0140013
146  GO:BP GO:0006284
147  GO:BP GO:1900264
148  GO:BP GO:1900262
149  GO:BP GO:0071478
150  GO:BP GO:1903083
151  GO:BP GO:1902117
152  GO:BP GO:0034501
153  GO:BP GO:0086067
154  GO:BP GO:0033554
155  GO:BP GO:0030174
156  GO:BP GO:0034644
157  GO:BP GO:1902115
158  GO:BP GO:0104004
159  GO:BP GO:0071214
160  GO:BP GO:0140694
161  GO:BP GO:0009112
162  GO:BP GO:0071103
163  GO:BP GO:0007099
164  GO:BP GO:0046053
165  GO:BP GO:0009215
166  GO:BP GO:0051129
167  GO:BP GO:0007062
168  GO:BP GO:0042148
169  GO:BP GO:0009314
170  GO:BP GO:0007076
171  GO:BP GO:0060444
172  GO:BP GO:1905832
173  GO:BP GO:0071897
174  GO:BP GO:0006268
175  GO:BP GO:0098534
176  GO:BP GO:0106380
177  GO:BP GO:0010032
178  GO:BP GO:0007079
179  GO:BP GO:0051321
180  GO:BP GO:0009156
181  GO:BP GO:0009084
182  GO:BP GO:0071479
183  GO:BP GO:0030510
184  GO:BP GO:0061642
185  GO:BP GO:0009200
186  GO:BP GO:0009124
187  GO:BP GO:1905821
188  GO:BP GO:0033260
189  GO:BP GO:0006290
190  GO:BP GO:1901751
191  GO:BP GO:0097294
192  GO:BP GO:0097293
193  GO:BP GO:0097292
194  GO:BP GO:0009170
195  GO:BP GO:0009167
196  GO:BP GO:0009113
197  GO:BP GO:0044314
198  GO:BP GO:0090267
199  GO:BP GO:0090232
200  GO:BP GO:0009126
201  GO:BP GO:0046601
202  GO:BP GO:0090235
203  GO:BP GO:0046129
204  GO:BP GO:0032261
205  GO:BP GO:0042451
206  GO:BP GO:0042455
207  GO:BP GO:0006302
208  GO:BP GO:1990227
209  GO:BP GO:0034508
210  GO:BP GO:0009147
211  GO:BP GO:0051298
212  GO:BP GO:0034599
213  GO:BP GO:0044837
214  GO:BP GO:0007064
215  GO:BP GO:0071496
216  GO:BP GO:0072331
217  GO:BP GO:0051656
218  GO:BP GO:1990170
219  GO:BP GO:0071585
220  GO:BP GO:0014029
221  GO:BP GO:0010825
222   KEGG KEGG:04115
223   KEGG KEGG:03410
224   KEGG KEGG:04110
225   KEGG KEGG:03030
226   KEGG KEGG:03430
227   KEGG KEGG:03440
228   KEGG KEGG:04217
229   KEGG KEGG:05322
230   KEGG KEGG:00230
231   KEGG KEGG:05034
232   KEGG KEGG:04613
233   KEGG KEGG:01524
                                                                           term_name
1                                                             chromosome segregation
2                                                                 mitotic cell cycle
3                                               mitotic sister chromatid segregation
4                                                       sister chromatid segregation
5                                                           mitotic nuclear division
6                                                         mitotic cell cycle process
7                                                   regulation of cell cycle process
8                                                                      cell division
9                                                           regulation of cell cycle
10                                                    nuclear chromosome segregation
11                                                                cell cycle process
12                                           mitotic cell cycle checkpoint signaling
13                                                   cell cycle checkpoint signaling
14                                                           chromosome organization
15                                                                        cell cycle
16                                                                  nuclear division
17                                         negative regulation of mitotic cell cycle
18                                                 negative regulation of cell cycle
19                                                                 organelle fission
20                                         negative regulation of cell cycle process
21                                 attachment of spindle microtubules to kinetochore
22                                                              spindle organization
23                                          cellular response to DNA damage stimulus
24                         microtubule cytoskeleton organization involved in mitosis
25                                                                  spindle assembly
26                                               regulation of chromosome separation
27                                negative regulation of cell cycle phase transition
28                                                      mitotic spindle organization
29                                              regulation of chromosome segregation
30                                                                        DNA repair
31                                             spindle assembly checkpoint signaling
32                                     mitotic spindle assembly checkpoint signaling
33                                              mitotic spindle checkpoint signaling
34                                                  regulation of mitotic cell cycle
35                                                             chromosome separation
36                                                      spindle checkpoint signaling
37                                               mitotic metaphase plate congression
38                                   negative regulation of mitotic nuclear division
39                      negative regulation of mitotic metaphase/anaphase transition
40                                 regulation of mitotic sister chromatid separation
41                                regulation of mitotic sister chromatid segregation
42                                                     DNA-templated DNA replication
43                                    negative regulation of chromosome organization
44                                                DNA integrity checkpoint signaling
45                                            regulation of mitotic nuclear division
46                       negative regulation of mitotic sister chromatid segregation
47                        negative regulation of mitotic sister chromatid separation
48                               negative regulation of sister chromatid segregation
49                negative regulation of metaphase/anaphase transition of cell cycle
50                                                       metaphase plate congression
51                                         regulation of cell cycle phase transition
52                                                       glutamine metabolic process
53                               regulation of mitotic metaphase/anaphase transition
54                                                                   DNA replication
55                                               mitotic sister chromatid separation
56                               metaphase/anaphase transition of mitotic cell cycle
57                   regulation of attachment of spindle microtubules to kinetochore
58                                                    regulation of nuclear division
59                                      negative regulation of chromosome separation
60                        negative regulation of mitotic cell cycle phase transition
61                                     negative regulation of chromosome segregation
62                                         positive regulation of cell cycle process
63                                        mitotic DNA integrity checkpoint signaling
64                                                         regulation of cytokinesis
65                         regulation of metaphase/anaphase transition of cell cycle
66                                     positive regulation of chromosome segregation
67                                           negative regulation of nuclear division
68                                       metaphase/anaphase transition of cell cycle
69                                                                spindle elongation
70                                        regulation of sister chromatid segregation
71                                     negative regulation of organelle organization
72                                                       cell cycle phase transition
73                                                  mitotic spindle midzone assembly
74                                 regulation of mitotic cell cycle phase transition
75                                                          spindle midzone assembly
76                                          establishment of chromosome localization
77                                                          mitotic spindle assembly
78                                                        DNA replication initiation
79                                           mitotic DNA damage checkpoint signaling
80                                             microtubule cytoskeleton organization
81                                                   DNA damage checkpoint signaling
82                                               mitotic cell cycle phase transition
83                                     signal transduction in response to DNA damage
84                                             regulation of chromosome organization
85                                                        mitotic spindle elongation
86                                                             translesion synthesis
87                                                           chromosome localization
88                                                            postreplication repair
89                                              regulation of organelle organization
90                               regulation of G2/M transition of mitotic cell cycle
91                                              DNA synthesis involved in DNA repair
92                                                               mitotic cytokinesis
93                                             G2/M transition of mitotic cell cycle
94                                                    response to ionizing radiation
95                                                     regulation of DNA replication
96                                                          kinetochore organization
97                                                                       cytokinesis
98                                                       regulation of cell division
99                         attachment of mitotic spindle microtubules to kinetochore
100                                                         AMP biosynthetic process
101                                DNA strand elongation involved in DNA replication
102                                       regulation of mitotic spindle organization
103                                      regulation of DNA-templated DNA replication
104                                                 cell cycle G2/M phase transition
105                                                         GMP biosynthetic process
106                                                                   response to UV
107                                               mitotic G2/M transition checkpoint
108                                       positive regulation of mitotic cytokinesis
109                                               regulation of spindle organization
110                                                           dATP metabolic process
111                                                             DNA duplex unwinding
112                                    glutamine family amino acid metabolic process
113                                                            DNA metabolic process
114                                                regulation of mitotic cytokinesis
115                                     positive regulation of chromosome separation
116                                                                 centrosome cycle
117                                   regulation of cell cycle G2/M phase transition
118                                               cytoskeleton-dependent cytokinesis
119                                                             phenotypic switching
120                                            regulation of chromosome condensation
121                     negative regulation of G2/M transition of mitotic cell cycle
122                   DNA damage response, signal transduction by p53 class mediator
123                                              regulation of cell cycle checkpoint
124                            DNA-templated DNA replication maintenance of fidelity
125                         purine ribonucleoside monophosphate biosynthetic process
126                                      regulation of mitotic centrosome separation
127                             purine nucleoside monophosphate biosynthetic process
128                                                            AMP metabolic process
129         positive regulation of attachment of spindle microtubules to kinetochore
130                                                positive regulation of cell cycle
131                                       microtubule organizing center organization
132                          negative regulation of cell cycle G2/M phase transition
133                                                                      GMP salvage
134                                                                      AMP salvage
135                                       mitotic G2 DNA damage checkpoint signaling
136                                                          mitotic DNA replication
137 positive regulation of attachment of mitotic spindle microtubules to kinetochore
138          regulation of attachment of mitotic spindle microtubules to kinetochore
139                                                       meiotic cell cycle process
140                                                            GMP metabolic process
141                                                       cell cycle DNA replication
142                                                             DNA geometric change
143                                                  nucleobase biosynthetic process
144                                                        microtubule-based process
145                                                         meiotic nuclear division
146                                                             base-excision repair
147                      positive regulation of DNA-directed DNA polymerase activity
148                               regulation of DNA-directed DNA polymerase activity
149                                                   cellular response to radiation
150                                     protein localization to condensed chromosome
151                                        positive regulation of organelle assembly
152                                              protein localization to kinetochore
153                                 AV node cell to bundle of His cell communication
154                                                      cellular response to stress
155                           regulation of DNA-templated DNA replication initiation
156                                                          cellular response to UV
157                                                 regulation of organelle assembly
158                                      cellular response to environmental stimulus
159                                            cellular response to abiotic stimulus
160                                          non-membrane-bounded organelle assembly
161                                                     nucleobase metabolic process
162                                                          DNA conformation change
163                                                            centriole replication
164                                                           dAMP metabolic process
165                        purine deoxyribonucleoside triphosphate metabolic process
166                           negative regulation of cellular component organization
167                                                        sister chromatid cohesion
168                                                                  strand invasion
169                                                            response to radiation
170                                                  mitotic chromosome condensation
171                           branching involved in mammary gland duct morphogenesis
172                                          positive regulation of spindle assembly
173                                                         DNA biosynthetic process
174                                        DNA unwinding involved in DNA replication
175                                                               centriole assembly
176                                                    purine ribonucleotide salvage
177                                                  meiotic chromosome condensation
178                                 mitotic chromosome movement towards spindle pole
179                                                               meiotic cell cycle
180                                ribonucleoside monophosphate biosynthetic process
181                                 glutamine family amino acid biosynthetic process
182                                          cellular response to ionizing radiation
183                                              regulation of BMP signaling pathway
184                                                          chemoattraction of axon
185                               deoxyribonucleoside triphosphate metabolic process
186                                    nucleoside monophosphate biosynthetic process
187                                   positive regulation of chromosome condensation
188                                                          nuclear DNA replication
189                                                          pyrimidine dimer repair
190                                                 leukotriene A4 metabolic process
191                                               'de novo' XMP biosynthetic process
192                                                         XMP biosynthetic process
193                                                            XMP metabolic process
194                       purine deoxyribonucleoside monophosphate metabolic process
195                            purine ribonucleoside monophosphate metabolic process
196                                           purine nucleobase biosynthetic process
197                                                protein K27-linked ubiquitination
198            positive regulation of mitotic cell cycle spindle assembly checkpoint
199                                        positive regulation of spindle checkpoint
200                                purine nucleoside monophosphate metabolic process
201                                     positive regulation of centriole replication
202                                        regulation of metaphase plate congression
203                                       purine ribonucleoside biosynthetic process
204                                                        purine nucleotide salvage
205                                           purine nucleoside biosynthetic process
206                                              ribonucleoside biosynthetic process
207                                                       double-strand break repair
208                                                   paranodal junction maintenance
209                                                      centromere complex assembly
210                             pyrimidine nucleoside triphosphate metabolic process
211                                                           centrosome duplication
212                                            cellular response to oxidative stress
213                                         actomyosin contractile ring organization
214                                                mitotic sister chromatid cohesion
215                                           cellular response to external stimulus
216                                        signal transduction by p53 class mediator
217                                          establishment of organelle localization
218                                                   stress response to cadmium ion
219                                                    detoxification of cadmium ion
220                                                           neural crest formation
221                                    positive regulation of centrosome duplication
222                                                            p53 signaling pathway
223                                                             Base excision repair
224                                                                       Cell cycle
225                                                                  DNA replication
226                                                                  Mismatch repair
227                                                         Homologous recombination
228                                                                      Necroptosis
229                                                     Systemic lupus erythematosus
230                                                                Purine metabolism
231                                                                       Alcoholism
232                                          Neutrophil extracellular trap formation
233                                                         Platinum drug resistance
    intersection_size term_size      p_value
1                 104       378 7.761675e-11
2                 148       833 7.761675e-11
3                  51       193 1.684802e-10
4                  71       234 1.684802e-10
5                  63       264 1.857227e-10
6                 118       700 3.881477e-09
7                 111       620 5.981330e-09
8                 132       567 6.780554e-09
9                 160       950 1.451525e-08
10                 81       287 1.994207e-08
11                174      1075 3.326181e-08
12                 51       136 5.344244e-08
13                 58       180 8.355485e-08
14                125       543 1.127831e-07
15                227      1522 1.528984e-07
16                 75       354 1.542841e-07
17                 80       208 1.542841e-07
18                 69       334 6.383180e-07
19                 77       397 2.217813e-06
20                 56       270 4.683310e-06
21                 20        42 5.137652e-06
22                 50       186 6.963121e-06
23                145       789 9.326354e-06
24                 36       156 1.234120e-05
25                 37       118 1.234120e-05
26                 22        69 1.234120e-05
27                 49       232 1.323319e-05
28                 31       128 1.989739e-05
29                 35       118 2.463882e-05
30                114       535 3.175578e-05
31                 16        44 3.599144e-05
32                 16        44 3.599144e-05
33                 16        44 3.599144e-05
34                111       438 3.914155e-05
35                 22        74 4.176183e-05
36                 16        45 4.617421e-05
37                 13        55 4.656906e-05
38                 18        54 4.852057e-05
39                 16        46 5.905068e-05
40                 18        58 7.472506e-05
41                 17        52 7.705491e-05
42                 46       149 8.261152e-05
43                 36        90 8.261152e-05
44                 39       126 8.261152e-05
45                 27       100 8.261152e-05
46                 16        47 8.768417e-05
47                 16        47 8.768417e-05
48                 16        47 8.768417e-05
49                 16        47 8.768417e-05
50                 14        69 8.982318e-05
51                 67       388 1.138697e-04
52                  4        23 1.138697e-04
53                 22        88 1.138697e-04
54                 74       258 1.138697e-04
55                 18        61 1.146467e-04
56                 29        91 1.146467e-04
57                 11        18 1.146467e-04
58                 29       115 1.219574e-04
59                 16        48 1.286693e-04
60                 33       163 1.286693e-04
61                 16        48 1.286693e-04
62                 55       206 1.495831e-04
63                 30        82 1.613626e-04
64                 22        79 1.654657e-04
65                 22        89 1.696210e-04
66                 16        25 1.898249e-04
67                 18        57 1.898249e-04
68                 29        92 1.910697e-04
69                  8        12 2.367083e-04
70                 34        99 2.385033e-04
71                 31       318 2.790685e-04
72                 79       499 2.790685e-04
73                  8         9 2.839664e-04
74                 29       305 2.839664e-04
75                  9        12 2.887919e-04
76                 14        75 4.047051e-04
77                 13        69 4.145875e-04
78                 19        35 4.171547e-04
79                 28        78 4.812191e-04
80                 85       552 5.367954e-04
81                 27       118 5.456826e-04
82                 78       413 6.125389e-04
83                 35       173 6.125389e-04
84                 54       233 6.734241e-04
85                  8        10 6.735957e-04
86                 11        24 6.809488e-04
87                 16        82 7.075890e-04
88                 13        34 8.860188e-04
89                 68      1023 9.963103e-04
90                 29        92 9.963103e-04
91                 16        36 1.045346e-03
92                 20        81 1.165705e-03
93                 37       134 1.392443e-03
94                 37       130 1.435698e-03
95                 45       124 1.462364e-03
96                 10        23 1.491808e-03
97                 32       163 1.956286e-03
98                 19       144 2.006680e-03
99                 12        21 2.008611e-03
100                 3        14 2.075985e-03
101                13        15 2.153384e-03
102                 8        42 2.189187e-03
103                24        54 2.304261e-03
104                39       148 2.384224e-03
105                 3        14 2.465006e-03
106                29       137 3.095554e-03
107                19        50 3.384593e-03
108                 6         7 3.532075e-03
109                 8        45 3.915209e-03
110                 2         3 4.519094e-03
111                24        75 5.124041e-03
112                 4        61 5.533211e-03
113               167       890 5.533211e-03
114                 7         8 5.851057e-03
115                11        26 6.554151e-03
116                26       126 6.731476e-03
117                29       102 6.731476e-03
118                22       103 6.960892e-03
119                 5         7 7.362368e-03
120                 6         9 7.502489e-03
121                21        60 7.818806e-03
122                10        68 7.818806e-03
123                13        45 7.893927e-03
124                17        50 7.893927e-03
125                 3        22 7.893927e-03
126                 6         8 8.010101e-03
127                 3        24 9.959807e-03
128                 3        22 9.959807e-03
129                 8        11 1.049253e-02
130                64       278 1.076319e-02
131                27       136 1.137847e-02
132                21        62 1.202319e-02
133                 2         4 1.230752e-02
134                 2         5 1.230752e-02
135                14        35 1.232321e-02
136                10        14 1.266604e-02
137                 6         8 1.266614e-02
138                 6         8 1.266614e-02
139                42       136 1.271601e-02
140                 3        24 1.286982e-02
141                15        40 1.329069e-02
142                24        81 1.390774e-02
143                 9        18 1.435514e-02
144                99       756 1.448065e-02
145                39       121 1.511139e-02
146                27        44 1.593546e-02
147                11        13 1.595661e-02
148                11        13 1.595661e-02
149                43       155 1.606052e-02
150                11        18 1.606052e-02
151                10        75 1.606052e-02
152                11        18 1.606052e-02
153                 4        11 1.622738e-02
154               229      1677 1.670952e-02
155                 9        14 1.670952e-02
156                22        83 1.747689e-02
157                17       186 1.770461e-02
158                49       264 1.826721e-02
159                49       264 1.826721e-02
160                54       355 1.972895e-02
161                 3        27 2.012675e-02
162                25        88 2.016374e-02
163                 3        38 2.071413e-02
164                 2         5 2.089122e-02
165                 2         7 2.089122e-02
166                41       586 2.118572e-02
167                29        51 2.120073e-02
168                 4         5 2.225399e-02
169                59       349 2.275495e-02
170                 8        19 2.302703e-02
171                11        20 2.401613e-02
172                 5         7 2.450214e-02
173                61       175 2.525370e-02
174                11        22 2.529172e-02
175                 3        41 2.529939e-02
176                 2         7 2.605259e-02
177                 4         6 2.637663e-02
178                 3         4 2.656177e-02
179                51       188 2.867890e-02
180                14        36 2.893246e-02
181                 2        17 2.939117e-02
182                23        68 3.104111e-02
183                 4        84 3.164313e-02
184                 2         2 3.164313e-02
185                 2         9 3.179169e-02
186                16        44 3.308425e-02
187                 4         5 3.334062e-02
188                13        35 3.386546e-02
189                 1         7 3.411213e-02
190                 2         2 3.687978e-02
191                 5         7 3.747961e-02
192                 5         7 3.747961e-02
193                 5         7 3.747961e-02
194                 2         7 3.780690e-02
195                 3        40 3.829968e-02
196                 6        10 3.964717e-02
197                 7         8 4.128687e-02
198                 9        12 4.128687e-02
199                 9        12 4.128687e-02
200                 3        42 4.245108e-02
201                 5         9 4.339878e-02
202                 7        13 4.339878e-02
203                 2        11 4.341438e-02
204                 2        10 4.341438e-02
205                 2        11 4.341438e-02
206                 2        11 4.341438e-02
207                78       270 4.427365e-02
208                 1         2 4.427365e-02
209                 9        30 4.578524e-02
210                17        22 4.578524e-02
211                 7        68 4.718014e-02
212                30       239 4.836155e-02
213                 4         7 4.927190e-02
214                17        29 4.927190e-02
215                 9       268 4.957881e-02
216                 9       160 4.957881e-02
217                51       375 4.965251e-02
218                 2         2 4.965251e-02
219                 2         2 4.965251e-02
220                 7        13 4.991615e-02
221                 1         4 4.999950e-02
222                10        65 5.669844e-06
223                25        33 6.024964e-05
224                11       121 1.467678e-04
225                25        35 3.367975e-04
226                17        22 1.258368e-03
227                11        39 6.991437e-03
228                 7       106 2.645195e-02
229                 2        61 2.645195e-02
230                 4        97 3.736728e-02
231                 2       122 3.736728e-02
232                 2       110 3.736728e-02
233                26        65 3.739828e-02

##Visualization of FC in cormotif sets


Attaching package: 'limma'

The following object is masked from 'package:BiocGenerics':

    plotMA

corrplot 0.92 loaded

[1] TRUE

##CVRI poster figures not run

R version 4.2.2 (2022-10-31 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19044)

Matrix products: default

locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

attached base packages:
[1] grid      stats     graphics  grDevices utils     datasets  methods  
[8] base     

other attached packages:
 [1] pheatmap_1.0.12     corrplot_0.92       limma_3.52.4       
 [4] ggpubr_0.6.0        cowplot_1.1.1       ggVennDiagram_1.2.2
 [7] scales_1.2.1        kableExtra_1.3.4    VennDiagram_1.7.3  
[10] futile.logger_1.4.3 gridExtra_2.3       BiocGenerics_0.42.0
[13] gprofiler2_0.2.1    lubridate_1.9.2     forcats_1.0.0      
[16] stringr_1.5.0       dplyr_1.1.0         purrr_1.0.1        
[19] readr_2.1.4         tidyr_1.3.0         tibble_3.1.8       
[22] ggplot2_3.4.1       tidyverse_2.0.0     workflowr_1.7.0    

loaded via a namespace (and not attached):
 [1] colorspace_2.1-0     ggsignif_0.6.4       ellipsis_0.3.2      
 [4] class_7.3-21         rprojroot_2.0.3      fs_1.6.1            
 [7] rstudioapi_0.14      proxy_0.4-27         farver_2.1.1        
[10] bit64_4.0.5          fansi_1.0.4          xml2_1.3.3          
[13] cachem_1.0.7         knitr_1.42           jsonlite_1.8.4      
[16] broom_1.0.3          shiny_1.7.4          compiler_4.2.2      
[19] httr_1.4.5           backports_1.4.1      fastmap_1.1.1       
[22] lazyeval_0.2.2       cli_3.6.0            later_1.3.0         
[25] formatR_1.14         htmltools_0.5.4      tools_4.2.2         
[28] gtable_0.3.1         glue_1.6.2           Rcpp_1.0.10         
[31] carData_3.0-5        jquerylib_0.1.4      vctrs_0.5.2         
[34] svglite_2.1.1        crosstalk_1.2.0      xfun_0.37           
[37] ps_1.7.2             rvest_1.0.3          timechange_0.2.0    
[40] mime_0.12            lifecycle_1.0.3      rstatix_0.7.2       
[43] getPass_0.2-2        vroom_1.6.1          hms_1.1.2           
[46] promises_1.2.0.1     parallel_4.2.2       RColorBrewer_1.1-3  
[49] lambda.r_1.2.4       yaml_2.3.7           sass_0.4.5          
[52] stringi_1.7.12       highr_0.10           e1071_1.7-13        
[55] rlang_1.0.6          pkgconfig_2.0.3      systemfonts_1.0.4   
[58] bitops_1.0-7         evaluate_0.20        sf_1.0-9            
[61] htmlwidgets_1.6.1    labeling_0.4.2       bit_4.0.5           
[64] processx_3.8.0       tidyselect_1.2.0     magrittr_2.0.3      
[67] R6_2.5.1             generics_0.1.3       DBI_1.1.3           
[70] pillar_1.8.1         whisker_0.4.1        withr_2.5.0         
[73] units_0.8-1          abind_1.4-5          RCurl_1.98-1.10     
[76] crayon_1.5.2         car_3.1-1            futile.options_1.0.1
[79] KernSmooth_2.23-20   utf8_1.2.3           plotly_4.10.1       
[82] RVenn_1.1.0          tzdb_0.3.0           rmarkdown_2.20      
[85] data.table_1.14.8    callr_3.7.3          git2r_0.31.0        
[88] digest_0.6.31        classInt_0.4-9       webshot_0.5.4       
[91] xtable_1.8-4         httpuv_1.6.9         munsell_0.5.0       
[94] viridisLite_0.4.1    bslib_0.4.2

GO analysis

ERM

2023-04-17

GO Analysis

A look at the Daunorubicin specific genes at 3 hours and how they may relate to 24 hour genes using GO analysis

Graphing GO of the Venn results

DXspecific response (only the subset unique to Dox)