Figure1
ERM
2023-06-15
Last updated: 2023-06-15
Checks: 7 0
Knit directory: Cardiotoxicity/
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| File | Version | Author | Date | Message |
|---|---|---|---|---|
| Rmd | f8f511a | reneeisnowhere | 2023-06-15 | updates and simplifications of code |
| html | f8f511a | reneeisnowhere | 2023-06-15 | updates and simplifications of code |
| html | 908b616 | reneeisnowhere | 2023-06-13 | Build site. |
| Rmd | 44ae8bb | reneeisnowhere | 2023-06-13 | picture check |
| html | f2d0e90 | reneeisnowhere | 2023-06-13 | Build site. |
| Rmd | 71b3ce2 | reneeisnowhere | 2023-06-13 | picture check |
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| Rmd | 1ebf470 | reneeisnowhere | 2023-06-12 | adding figure 1 |
Figure 1
Top2i drugs affect cardiomyocyte viability in a dose dependent manner.
A. Project Overview
things to note about this image so far: Need to import into illustrator. Goal is to have colors changes on Drugs from sick purple and jaundice yellow, to a red tone and a blue tone for non-ACs. I also want to change to add a time line of treatment.
B. Example Dose response curves from 48 hour drug exposure.
Lines are a log-logistic regression of the mean from quadruplicates at 8 separate concentrations for each condition, except (trastuzmab)TRZ, which is 7 concentrations.
{30%}
C 48 hour 50% leathal dose plot
library(car)
#library(dr4pl) no longer used
library(tidyverse)
library(tinytex)
library(BiocGenerics)
library(data.table)
library(drc)
# library(Hmisc)
# library(cowplot)
# library(grid)
library(ggsignif)
library(RColorBrewer)
library(broom)
sessionInfo()R version 4.2.2 (2022-10-31 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)
Matrix products: default
locale:
[1] LC_COLLATE=English_United States.utf8
[2] LC_CTYPE=English_United States.utf8
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C
[5] LC_TIME=English_United States.utf8
attached base packages:
[1] stats graphics grDevices utils datasets methods base
other attached packages:
[1] broom_1.0.5 RColorBrewer_1.1-3 ggsignif_0.6.4
[4] drc_3.0-1 MASS_7.3-60 data.table_1.14.8
[7] BiocGenerics_0.42.0 tinytex_0.45 lubridate_1.9.2
[10] forcats_1.0.0 stringr_1.5.0 dplyr_1.1.2
[13] purrr_1.0.1 readr_2.1.4 tidyr_1.3.0
[16] tibble_3.2.1 ggplot2_3.4.2 tidyverse_2.0.0
[19] car_3.1-2 carData_3.0-5 workflowr_1.7.0
loaded via a namespace (and not attached):
[1] Rcpp_1.0.10 mvtnorm_1.2-2 lattice_0.21-8 zoo_1.8-12
[5] getPass_0.2-2 ps_1.7.5 gtools_3.9.4 rprojroot_2.0.3
[9] digest_0.6.31 utf8_1.2.3 R6_2.5.1 backports_1.4.1
[13] evaluate_0.21 httr_1.4.6 highr_0.10 pillar_1.9.0
[17] rlang_1.1.1 multcomp_1.4-24 rstudioapi_0.14 whisker_0.4.1
[21] callr_3.7.3 jquerylib_0.1.4 Matrix_1.5-4.1 rmarkdown_2.22
[25] splines_4.2.2 munsell_0.5.0 compiler_4.2.2 httpuv_1.6.11
[29] xfun_0.39 pkgconfig_2.0.3 htmltools_0.5.5 tidyselect_1.2.0
[33] codetools_0.2-19 fansi_1.0.4 tzdb_0.4.0 withr_2.5.0
[37] later_1.3.1 grid_4.2.2 jsonlite_1.8.5 gtable_0.3.3
[41] lifecycle_1.0.3 git2r_0.32.0 magrittr_2.0.3 scales_1.2.1
[45] cli_3.6.1 stringi_1.7.12 cachem_1.0.8 fs_1.6.2
[49] promises_1.2.0.1 bslib_0.5.0 generics_0.1.3 vctrs_0.6.2
[53] sandwich_3.0-2 TH.data_1.1-2 tools_4.2.2 glue_1.6.2
[57] hms_1.1.3 plotrix_3.8-2 survival_3.5-5 processx_3.8.1
[61] abind_1.4-5 fastmap_1.1.1 yaml_2.3.7 timechange_0.2.0
[65] colorspace_2.1-0 knitr_1.43 sass_0.4.6