Dose response curve
Last updated: 2025-04-16
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Knit directory: CX5461_Project/
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📌 CX and DOX dose response curve (Combined)
library(drc)Warning: package 'drc' was built under R version 4.3.2Warning: package 'MASS' was built under R version 4.3.1# Load Data
DRC <- read.csv("data/CX-5461.csv")
DRC2 <- read.csv("data/DOX.csv")
# Fit dose-response models with fixed min = 0 and max = 1
curved_fit <- drm(Ratio ~ Conc, data = DRC,
fct = LL.4(fixed = c(NA, 0, 1, NA),
names = c("hill", "min", "max", "EC50")))
curved_fit2 <- drm(Ratio ~ Conc, data = DRC2,
fct = LL.4(fixed = c(NA, 0, 1, NA),
names = c("hill", "min", "max", "EC50")))
# Extract EC50 values
EC50_CX <- summary(curved_fit)$coefficients["EC50:(Intercept)", "Estimate"]
EC50_DOX <- summary(curved_fit2)$coefficients["EC50:(Intercept)", "Estimate"]
# Set up plot with slightly wider margins to avoid label clipping
par(mfrow = c(1,1), mar = c(5, 4, 2, 2)) # more space at bottom
# Base plot (CX curve) with extra y-limit for spacing
plot(curved_fit, type = "none", broken = FALSE,
col = "#08306B", lwd = 3.5,
xlab = "Concentration (uM)", ylab = "Proportion of Viable Cells",
main = "Dose-Response Curves with LD50",
xlim = c(0, 50),
ylim = c(0, 1.1), xaxs = "i", yaxs = "i", axes = FALSE)
# Custom axes
axis(1, at = c(0, 0.1, 0.5, 1, 5, 10, 50), las = 1) # Ensure 0 is shown
axis(2, at = seq(0, 1, by = 0.2)) # Y-axis up to 1 only
box()
# Overlay DOX curve
par(new = TRUE)
plot(curved_fit2, add = TRUE, type = "none", col = "#E7298A", lwd = 3.5)
# Add LD50 vertical lines
abline(v = EC50_CX, col = "#08306B", lty = 2, lwd = 2)
abline(v = EC50_DOX, col = "#E7298A", lty = 2, lwd = 2)
# LD50 text labels slightly lowered (e.g., 0.95 and 0.85)
text(EC50_CX, 0.95, labels = paste("LD50 CX:", round(EC50_CX, 2)), col = "#08306B", pos = 4, cex = 0.9, font = 2)
text(EC50_DOX, 0.85, labels = paste("LD50 DOX:", round(EC50_DOX, 2)), col = "#E7298A", pos = 4, cex = 0.9, font = 2)
# Legend in bottom-left
legend("bottomleft", legend = c("CX-5461", "DOX"),
col = c("#08306B", "#E7298A"), lty = 1, lwd = 3.5, cex = 1)
📌 CX and DOX dose response curve (Individual)
################Combined#################
library(drc)
library(dplyr)Warning: package 'dplyr' was built under R version 4.3.2library(ggplot2)
# Load CX-5461 and DOX data
DRC <- read.csv("data/CX-5461.csv")
DRC2 <- read.csv("data/DOX.csv")
# Define individual labels
individual_map <- list(
`75-1` = "Ind1",
`78-1` = "Ind2",
`87-1` = "Ind3"
)
# --- CX-5461: Predict from 0.01 to 50 µM
pred_conc_cx <- exp(seq(log(0.01), log(50), length.out = 200))
fits_cx <- DRC %>%
group_split(Indv) %>%
setNames(unique(DRC$Indv)) %>%
lapply(function(df) {
tryCatch({
drm(Ratio ~ Conc, data = df, fct = LL.4(fixed = c(NA, 0, 1, NA)))
}, error = function(e) NULL)
})
curve_data_cx <- do.call(rbind, lapply(names(fits_cx), function(name) {
fit <- fits_cx[[name]]
if (!is.null(fit)) {
indiv <- individual_map[[name]]
preds <- predict(fit, newdata = data.frame(Conc = pred_conc_cx))
data.frame(Conc = pred_conc_cx, Ratio = preds, Label = paste0(indiv, "_CX"))
}
}))
# --- DOX: Predict from 0.01 to 10 µM
pred_conc_dox <- exp(seq(log(0.01), log(10), length.out = 200))
fits_dox <- DRC2 %>%
group_split(Indv) %>%
setNames(unique(DRC2$Indv)) %>%
lapply(function(df) {
tryCatch({
drm(Ratio ~ Conc, data = df, fct = LL.4(fixed = c(NA, 0, 1, NA)))
}, error = function(e) NULL)
})
curve_data_dox <- do.call(rbind, lapply(names(fits_dox), function(name) {
fit <- fits_dox[[name]]
if (!is.null(fit)) {
indiv <- individual_map[[name]]
preds <- predict(fit, newdata = data.frame(Conc = pred_conc_dox))
data.frame(Conc = pred_conc_dox, Ratio = preds, Label = paste0(indiv, "_DOX"))
}
}))
# Combine all curve data
combined_data <- bind_rows(curve_data_cx, curve_data_dox)
# Add Drug and Individual columns for aesthetic mapping
combined_data <- combined_data %>%
mutate(
Drug = ifelse(grepl("_CX$", Label), "CX-5461", "DOX"),
Indv = case_when(
grepl("^Ind1", Label) ~ "Ind1",
grepl("^Ind2", Label) ~ "Ind2",
grepl("^Ind3", Label) ~ "Ind3"
)
)
# Define line types for individuals
line_types <- c("Ind1" = "dotted", "Ind2" = "dashed", "Ind3" = "solid")
# Define simplified color palette for drugs
drug_colors <- c("CX-5461" = "#08306B", "DOX" = "#E7298A")
# Plot
ggplot(combined_data, aes(x = Conc, y = Ratio, color = Drug, linetype = Indv)) +
geom_line(size = 1.5) +
scale_color_manual(values = drug_colors) +
scale_linetype_manual(values = line_types) +
scale_x_log10(
limits = c(0.01, 50),
breaks = c(0.01, 0.1, 1, 10, 50),
labels = c("0.01", "0.1", "1", "10", "50")
) +
labs(
title = "CX-5461 and DOX Cell Viability Curves",
x = "Concentration (μM)",
y = "Proportion of Viable Cells",
color = "Drug",
linetype = "Individual"
) +
theme_minimal(base_size = 14) +
theme(
plot.title = element_text(face = "bold", hjust = 0.5),
legend.title = element_text(face = "bold"),
legend.position = "right",
panel.grid.minor = element_blank(),
axis.text = element_text(color = "black"),
axis.title = element_text(color = "black"),
plot.background = element_rect(fill = "white", color = NA),
panel.border = element_rect(fill = NA, color = "black", linewidth = 1)
)Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
ℹ Please use `linewidth` instead.
This warning is displayed once every 8 hours.
Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
generated.
📌 CX and DOX dose response curve (Confidence)
library(drc)
# Load Data
DRC <- read.csv("data/CX-5461.csv")
DRC2 <- read.csv("data/DOX.csv")
# Fit dose-response models with fixed min = 0 and max = 1
curved_fit <- drm(Ratio ~ Conc, data = DRC,
fct = LL.4(fixed = c(NA, 0, 1, NA)))
curved_fit2 <- drm(Ratio ~ Conc, data = DRC2,
fct = LL.4(fixed = c(NA, 0, 1, NA)))
# Extract EC50 values
EC50_CX <- coef(curved_fit)[4]
EC50_DOX <- coef(curved_fit2)[4]
# Generate prediction ranges
xvals_cx <- exp(seq(log(0.01), log(50), length.out = 200))
xvals_dox <- exp(seq(log(0.01), log(10), length.out = 200))
# Predict with confidence intervals
preds_cx <- predict(curved_fit, newdata = data.frame(Conc = xvals_cx), interval = "confidence")Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
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Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.preds_dox <- predict(curved_fit2, newdata = data.frame(Conc = xvals_dox), interval = "confidence")Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.
Warning in (tquan * sqrt(varVal + sumObjRV)) * c(-1, 1): Recycling array of length 1 in array-vector arithmetic is deprecated.
Use c() or as.vector() instead.# Set up log-scale plot
par(mfrow = c(1,1), mar = c(5, 5, 3, 2))
plot(NA, NA, log = "x",
xlim = c(0.01, 50), ylim = c(0, 1.1),
xlab = "Concentration (uM)", ylab = "Proportion of Viable Cells",
main = "Dose-Response Curves with Confidence",
axes = FALSE)
# Axes
axis(1, at = c(0.01, 0.1, 0.5, 1, 5, 10, 50), labels = c("0.01", "0.1", "0.5", "1", "5", "10", "50"))
axis(2, at = seq(0, 1, 0.2))
box()
# Confidence bands
polygon(c(xvals_cx, rev(xvals_cx)),
c(preds_cx[,"Lower"], rev(preds_cx[,"Upper"])),
col = adjustcolor("#08306B", alpha.f = 0.2), border = NA)
polygon(c(xvals_dox, rev(xvals_dox)),
c(preds_dox[,"Lower"], rev(preds_dox[,"Upper"])),
col = adjustcolor("#E7298A", alpha.f = 0.2), border = NA)
# Curves
lines(xvals_cx, preds_cx[,"Prediction"], col = "#08306B", lwd = 3.5)
lines(xvals_dox, preds_dox[,"Prediction"], col = "#E7298A", lwd = 3.5)
# LD50 vertical lines
abline(v = EC50_CX, col = "#08306B", lty = 2, lwd = 2)
abline(v = EC50_DOX, col = "#E7298A", lty = 2, lwd = 2)
# LD50 labels
text(EC50_CX, 1.02, paste("LD50 CX:", round(EC50_CX, 2)),
col = "#08306B", cex = 0.9, font = 2, pos = 4)
text(EC50_DOX, 0.92, paste("LD50 DOX:", round(EC50_DOX, 2)),
col = "#E7298A", cex = 0.9, font = 2, pos = 4)
# Legend
legend("bottomleft", legend = c("CX-5461", "DOX"),
col = c("#08306B", "#E7298A"), lty = 1, lwd = 3.5, bty = "n")
| Version | Author | Date |
|---|---|---|
| 7243dd2 | sayanpaul01 | 2025-04-16 |
sessionInfo()R version 4.3.0 (2023-04-21 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 11 x64 (build 26100)
Matrix products: default
locale:
[1] LC_COLLATE=English_United States.utf8
[2] LC_CTYPE=English_United States.utf8
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C
[5] LC_TIME=English_United States.utf8
time zone: America/Chicago
tzcode source: internal
attached base packages:
[1] stats graphics grDevices utils datasets methods base
other attached packages:
[1] ggplot2_3.5.2 dplyr_1.1.4 drc_3.0-1 MASS_7.3-60
loaded via a namespace (and not attached):
[1] generics_0.1.3 sandwich_3.1-1 sass_0.4.10 gtools_3.9.5
[5] stringi_1.8.3 lattice_0.22-7 digest_0.6.34 magrittr_2.0.3
[9] evaluate_1.0.3 grid_4.3.0 mvtnorm_1.3-3 fastmap_1.2.0
[13] rprojroot_2.0.4 workflowr_1.7.1 jsonlite_2.0.0 Matrix_1.6-1.1
[17] whisker_0.4.1 Formula_1.2-5 survival_3.8-3 multcomp_1.4-28
[21] promises_1.3.2 scales_1.3.0 TH.data_1.1-3 codetools_0.2-20
[25] jquerylib_0.1.4 abind_1.4-8 cli_3.6.1 crayon_1.5.3
[29] rlang_1.1.3 munsell_0.5.1 splines_4.3.0 withr_3.0.2
[33] plotrix_3.8-4 cachem_1.1.0 yaml_2.3.10 tools_4.3.0
[37] colorspace_2.1-0 httpuv_1.6.15 vctrs_0.6.5 R6_2.6.1
[41] zoo_1.8-14 lifecycle_1.0.4 git2r_0.36.2 stringr_1.5.1
[45] fs_1.6.3 car_3.1-3 pkgconfig_2.0.3 gtable_0.3.6
[49] pillar_1.10.2 bslib_0.9.0 later_1.3.2 glue_1.7.0
[53] Rcpp_1.0.12 tidyselect_1.2.1 xfun_0.52 tibble_3.2.1
[57] rstudioapi_0.17.1 knitr_1.50 farver_2.1.2 htmltools_0.5.8.1
[61] labeling_0.4.3 rmarkdown_2.29 carData_3.0-5 compiler_4.3.0