Last updated: 2024-07-02
Checks: 7 0
Knit directory: misc/analysis/
This reproducible R Markdown analysis was created with workflowr (version 1.7.1). The Checks tab describes the reproducibility checks that were applied when the results were created. The Past versions tab lists the development history.
Great! Since the R Markdown file has been committed to the Git repository, you know the exact version of the code that produced these results.
Great job! The global environment was empty. Objects defined in the global environment can affect the analysis in your R Markdown file in unknown ways. For reproduciblity it’s best to always run the code in an empty environment.
The command set.seed(1)
was run prior to running the
code in the R Markdown file. Setting a seed ensures that any results
that rely on randomness, e.g. subsampling or permutations, are
reproducible.
Great job! Recording the operating system, R version, and package versions is critical for reproducibility.
Nice! There were no cached chunks for this analysis, so you can be confident that you successfully produced the results during this run.
Great job! Using relative paths to the files within your workflowr project makes it easier to run your code on other machines.
Great! You are using Git for version control. Tracking code development and connecting the code version to the results is critical for reproducibility.
The results in this page were generated with repository version a1e004a. See the Past versions tab to see a history of the changes made to the R Markdown and HTML files.
Note that you need to be careful to ensure that all relevant files for
the analysis have been committed to Git prior to generating the results
(you can use wflow_publish
or
wflow_git_commit
). workflowr only checks the R Markdown
file, but you know if there are other scripts or data files that it
depends on. Below is the status of the Git repository when the results
were generated:
Ignored files:
Ignored: .DS_Store
Ignored: .Rhistory
Ignored: .Rproj.user/
Ignored: analysis/.RData
Ignored: analysis/.Rhistory
Ignored: analysis/ALStruct_cache/
Ignored: data/.Rhistory
Ignored: data/methylation-data-for-matthew.rds
Ignored: data/pbmc/
Ignored: data/pbmc_purified.RData
Untracked files:
Untracked: .dropbox
Untracked: Icon
Untracked: analysis/GHstan.Rmd
Untracked: analysis/GTEX-cogaps.Rmd
Untracked: analysis/PACS.Rmd
Untracked: analysis/Rplot.png
Untracked: analysis/SPCAvRP.rmd
Untracked: analysis/abf_comparisons.Rmd
Untracked: analysis/admm_02.Rmd
Untracked: analysis/admm_03.Rmd
Untracked: analysis/cache/
Untracked: analysis/cholesky.Rmd
Untracked: analysis/compare-transformed-models.Rmd
Untracked: analysis/cormotif.Rmd
Untracked: analysis/cp_ash.Rmd
Untracked: analysis/eQTL.perm.rand.pdf
Untracked: analysis/eb_prepilot.Rmd
Untracked: analysis/eb_var.Rmd
Untracked: analysis/ebpmf1.Rmd
Untracked: analysis/ebpmf_sla_text.Rmd
Untracked: analysis/ebspca_sims.Rmd
Untracked: analysis/explore_psvd.Rmd
Untracked: analysis/fa_check_identify.Rmd
Untracked: analysis/fa_iterative.Rmd
Untracked: analysis/flash_test_tree.Rmd
Untracked: analysis/flash_tree.Rmd
Untracked: analysis/flashier_newgroups.Rmd
Untracked: analysis/flashier_nmf_triples.Rmd
Untracked: analysis/flashier_pbmc.Rmd
Untracked: analysis/flashier_snn_shifted_prior.Rmd
Untracked: analysis/greedy_ebpmf_exploration_00.Rmd
Untracked: analysis/ieQTL.perm.rand.pdf
Untracked: analysis/lasso_em_03.Rmd
Untracked: analysis/m6amash.Rmd
Untracked: analysis/mash_bhat_z.Rmd
Untracked: analysis/mash_ieqtl_permutations.Rmd
Untracked: analysis/methylation_example.Rmd
Untracked: analysis/mixsqp.Rmd
Untracked: analysis/mr.ash_lasso_init.Rmd
Untracked: analysis/mr.mash.test.Rmd
Untracked: analysis/mr_ash_modular.Rmd
Untracked: analysis/mr_ash_parameterization.Rmd
Untracked: analysis/mr_ash_ridge.Rmd
Untracked: analysis/mv_gaussian_message_passing.Rmd
Untracked: analysis/nejm.Rmd
Untracked: analysis/nmf_bg.Rmd
Untracked: analysis/normal_conditional_on_r2.Rmd
Untracked: analysis/normalize.Rmd
Untracked: analysis/pbmc.Rmd
Untracked: analysis/pca_binary_weighted.Rmd
Untracked: analysis/pca_l1.Rmd
Untracked: analysis/poisson_nmf_approx.Rmd
Untracked: analysis/poisson_shrink.Rmd
Untracked: analysis/poisson_transform.Rmd
Untracked: analysis/qrnotes.txt
Untracked: analysis/ridge_iterative_02.Rmd
Untracked: analysis/ridge_iterative_splitting.Rmd
Untracked: analysis/samps/
Untracked: analysis/sc_bimodal.Rmd
Untracked: analysis/shrinkage_comparisons_changepoints.Rmd
Untracked: analysis/susie_cov.Rmd
Untracked: analysis/susie_en.Rmd
Untracked: analysis/susie_z_investigate.Rmd
Untracked: analysis/svd-timing.Rmd
Untracked: analysis/temp.RDS
Untracked: analysis/temp.Rmd
Untracked: analysis/test-figure/
Untracked: analysis/test.Rmd
Untracked: analysis/test.Rpres
Untracked: analysis/test.md
Untracked: analysis/test_qr.R
Untracked: analysis/test_sparse.Rmd
Untracked: analysis/tree_dist_top_eigenvector.Rmd
Untracked: analysis/z.txt
Untracked: code/multivariate_testfuncs.R
Untracked: code/rqb.hacked.R
Untracked: data/4matthew/
Untracked: data/4matthew2/
Untracked: data/E-MTAB-2805.processed.1/
Untracked: data/ENSG00000156738.Sim_Y2.RDS
Untracked: data/GDS5363_full.soft.gz
Untracked: data/GSE41265_allGenesTPM.txt
Untracked: data/Muscle_Skeletal.ACTN3.pm1Mb.RDS
Untracked: data/P.rds
Untracked: data/Thyroid.FMO2.pm1Mb.RDS
Untracked: data/bmass.HaemgenRBC2016.MAF01.Vs2.MergedDataSources.200kRanSubset.ChrBPMAFMarkerZScores.vs1.txt.gz
Untracked: data/bmass.HaemgenRBC2016.Vs2.NewSNPs.ZScores.hclust.vs1.txt
Untracked: data/bmass.HaemgenRBC2016.Vs2.PreviousSNPs.ZScores.hclust.vs1.txt
Untracked: data/eb_prepilot/
Untracked: data/finemap_data/fmo2.sim/b.txt
Untracked: data/finemap_data/fmo2.sim/dap_out.txt
Untracked: data/finemap_data/fmo2.sim/dap_out2.txt
Untracked: data/finemap_data/fmo2.sim/dap_out2_snp.txt
Untracked: data/finemap_data/fmo2.sim/dap_out_snp.txt
Untracked: data/finemap_data/fmo2.sim/data
Untracked: data/finemap_data/fmo2.sim/fmo2.sim.config
Untracked: data/finemap_data/fmo2.sim/fmo2.sim.k
Untracked: data/finemap_data/fmo2.sim/fmo2.sim.k4.config
Untracked: data/finemap_data/fmo2.sim/fmo2.sim.k4.snp
Untracked: data/finemap_data/fmo2.sim/fmo2.sim.ld
Untracked: data/finemap_data/fmo2.sim/fmo2.sim.snp
Untracked: data/finemap_data/fmo2.sim/fmo2.sim.z
Untracked: data/finemap_data/fmo2.sim/pos.txt
Untracked: data/logm.csv
Untracked: data/m.cd.RDS
Untracked: data/m.cdu.old.RDS
Untracked: data/m.new.cd.RDS
Untracked: data/m.old.cd.RDS
Untracked: data/mainbib.bib.old
Untracked: data/mat.csv
Untracked: data/mat.txt
Untracked: data/mat_new.csv
Untracked: data/matrix_lik.rds
Untracked: data/paintor_data/
Untracked: data/running_data_chris.csv
Untracked: data/running_data_matthew.csv
Untracked: data/temp.txt
Untracked: data/y.txt
Untracked: data/y_f.txt
Untracked: data/zscore_jointLCLs_m6AQTLs_susie_eQTLpruned.rds
Untracked: data/zscore_jointLCLs_random.rds
Untracked: explore_udi.R
Untracked: output/fit.k10.rds
Untracked: output/fit.nn.pbmc.purified.rds
Untracked: output/fit.nn.rds
Untracked: output/fit.nn.s.001.rds
Untracked: output/fit.nn.s.01.rds
Untracked: output/fit.nn.s.1.rds
Untracked: output/fit.nn.s.10.rds
Untracked: output/fit.snn.s.001.rds
Untracked: output/fit.snn.s.01.nninit.rds
Untracked: output/fit.snn.s.01.rds
Untracked: output/fit.varbvs.RDS
Untracked: output/fit2.nn.pbmc.purified.rds
Untracked: output/glmnet.fit.RDS
Untracked: output/snn07.txt
Untracked: output/snn34.txt
Untracked: output/test.bv.txt
Untracked: output/test.gamma.txt
Untracked: output/test.hyp.txt
Untracked: output/test.log.txt
Untracked: output/test.param.txt
Untracked: output/test2.bv.txt
Untracked: output/test2.gamma.txt
Untracked: output/test2.hyp.txt
Untracked: output/test2.log.txt
Untracked: output/test2.param.txt
Untracked: output/test3.bv.txt
Untracked: output/test3.gamma.txt
Untracked: output/test3.hyp.txt
Untracked: output/test3.log.txt
Untracked: output/test3.param.txt
Untracked: output/test4.bv.txt
Untracked: output/test4.gamma.txt
Untracked: output/test4.hyp.txt
Untracked: output/test4.log.txt
Untracked: output/test4.param.txt
Untracked: output/test5.bv.txt
Untracked: output/test5.gamma.txt
Untracked: output/test5.hyp.txt
Untracked: output/test5.log.txt
Untracked: output/test5.param.txt
Unstaged changes:
Modified: .gitignore
Modified: analysis/flashier_log1p.Rmd
Modified: analysis/flashier_sla_text.Rmd
Modified: analysis/logistic_z_scores.Rmd
Modified: analysis/mr_ash_pen.Rmd
Modified: analysis/susie_flash.Rmd
Note that any generated files, e.g. HTML, png, CSS, etc., are not included in this status report because it is ok for generated content to have uncommitted changes.
These are the previous versions of the repository in which changes were
made to the R Markdown (analysis/poisson_log1p.Rmd
) and
HTML (docs/poisson_log1p.html
) files. If you’ve configured
a remote Git repository (see ?wflow_git_remote
), click on
the hyperlinks in the table below to view the files as they were in that
past version.
File | Version | Author | Date | Message |
---|---|---|---|---|
Rmd | a1e004a | Matthew Stephens | 2024-07-02 | workflowr::wflow_publish("poisson_log1p.Rmd") |
I wanted to look at normal approximation to the Poisson log-likelihood with the log1p link.
The model is: \[Y \sim Poisson(\lambda)\]
\[\log(1+\lambda) = b, (b>0)\] So \[Y | b \sim Poisson(\exp(b)-1)\] The log-likelihood is \[l(b) = Y \log(\exp(b)-1) - (\exp(b)-1)\] The derivative of the log-likelihood is \[l'(b) = Y \frac{\exp(b)}{\exp(b)-1} - \exp(b)\] The second derivative of the log-likelihood is \[l''(b) = Y \frac{-exp(b)}{(\exp(b)-1)^2} - \exp(b) = -exp(b)(Y/(exp(b)-1)^2 + 1)\]
Writing the RHS in terms of \(\lambda = exp(b)-1\) we have \[l''(b) = -(\lambda+1)[Y/\lambda^2 + 1]\] Also the mle for b is \(\hat{b} = log(1+Y)\)
This suggests the normal approximation to the likelihood of \(l(b) \approx N(b; \hat{b}, s^2)\) where \[s^2 = -1/l''(\hat{b}) = 1/(\hat{\lambda}+1)[Y/\hat{\lambda}^2 + 1] = 1/(Y+1)(1/Y+1)=Y/(1+Y)^2 \quad (Y>0)\] and \(s^2 = 1\) for \(Y=0\).
First we plot the log-likelihood for \(Y=1\) as a function of \(b\). Then we overlay the normal approximation to the log-likelihood for \(Y=1\).
b = seq(0,3,length=100)
loglik = function(b,Y) {
if(Y==0){
return(-(exp(b)-1))}
else
return(Y*log(exp(b)-1) - (exp(b)-1))
}
y = 1
ll = loglik(b,y)
plot(b,ll-max(ll),type="l",xlab="b",ylab="log-likelihood",main="log-likelihood for Y=1")
s2 = y/(1+y)^2
bhat = log(y+1)
ll_approx = dnorm(b,bhat,sqrt(s2),log=TRUE)
lines(b,ll_approx-max(ll_approx),col="red")
Do the same for \(y=2\):
y = 2
ll = loglik(b,y)
plot(b,ll-max(ll),type="l",xlab="b",ylab="log-likelihood",main="log-likelihood for Y=2")
s2 = y/(1+y)^2
bhat = log(y+1)
ll_approx = dnorm(b,bhat,sqrt(s2),log=TRUE)
lines(b,ll_approx-max(ll_approx),col="red")
For \(Y=0\) we see a problem: the derivative of the log-likelihood does not vanish at \(b=0\) (it is -1). So we need to modify the normal approximation to be \(N(-1,1)\) rather than \(N(0,1)\).
b = seq(0,1,length=100)
y = 0
ll = loglik(b,y)
plot(b,ll-max(ll),type="l",xlab="b",ylab="log-likelihood",main="log-likelihood for Y=0")
s2 = 1
bhat = -1
ll_approx = dnorm(b,bhat,sqrt(s2),log=TRUE)
lines(b,ll_approx-max(ll_approx),col="red")
sessionInfo()
R version 4.2.1 (2022-06-23)
Platform: x86_64-apple-darwin17.0 (64-bit)
Running under: macOS Big Sur ... 10.16
Matrix products: default
BLAS: /Library/Frameworks/R.framework/Versions/4.2/Resources/lib/libRblas.0.dylib
LAPACK: /Library/Frameworks/R.framework/Versions/4.2/Resources/lib/libRlapack.dylib
locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8
attached base packages:
[1] stats graphics grDevices utils datasets methods base
loaded via a namespace (and not attached):
[1] Rcpp_1.0.12 rstudioapi_0.15.0 whisker_0.4.1 knitr_1.45
[5] magrittr_2.0.3 workflowr_1.7.1 R6_2.5.1 rlang_1.1.2
[9] fastmap_1.1.1 fansi_1.0.6 highr_0.10 stringr_1.5.1
[13] tools_4.2.1 xfun_0.41 utf8_1.2.4 cli_3.6.2
[17] git2r_0.33.0 jquerylib_0.1.4 htmltools_0.5.7 rprojroot_2.0.4
[21] yaml_2.3.8 digest_0.6.33 tibble_3.2.1 lifecycle_1.0.4
[25] later_1.3.2 sass_0.4.8 vctrs_0.6.5 fs_1.6.3
[29] promises_1.2.1 cachem_1.0.8 glue_1.6.2 evaluate_0.23
[33] rmarkdown_2.25 stringi_1.8.3 bslib_0.6.1 compiler_4.2.1
[37] pillar_1.9.0 jsonlite_1.8.8 httpuv_1.6.13 pkgconfig_2.0.3