M&M RSS ukb

Last updated: 2021-01-08

Checks: 2 0

Knit directory: mmbr-rss-dsc/

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File	Version	Author	Date	Message
Rmd	e1aed76	zouyuxin	2021-01-08	wflow_publish(“analysis/mmbr_rss_ukb_simulation_20210107.Rmd”)
Rmd	c0cfcbe	zouyuxin	2021-01-08	add new simulation result

This is result from our M&M RSS simulation using UKB data. There are 600 datasets. The max PVE across traits is 0.0005.

For each dataset, we simulate signals using 2 type of priors, the details are here

Artificial mixture: 20 conditions. The oracle residual variance is a diagonal matrix.
UKB Bloodcells mixture: 16 conditions. The oracle residual variance is a dense matrix.

We estimate prior weights using ‘EM’ method.

Overall: Ignoring correlation between conditions in residual matrix results in poor fit.