Last updated: 2022-07-20
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Knit directory: mmbr-rss-dsc/
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This is result from our mvSuSiE RSS simulation using UKB data. There are 600 datasets. The max PVE across traits is 0.0005.
For each dataset, we simulate signals using 2 type of priors, the details are here
Artificial mixture: 20 conditions. The oracle residual variance is a diagonal matrix.
UKB Bloodcells mixture: 16 conditions. The oracle residual variance is a dense matrix.
We estimate prior weights using ‘EM’ method.
Using data-driven prior
Artificial Mixture
UKB Bloodcells Mixture
The residual variance matrix is estimated using z scores
The prior is oracle.
Using data-driven prior and z score estimated residual correlation matrix.
Artificial Mixture
UKB Bloodcells Mixture