Last updated: 2020-09-21
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Knit directory: mmbr-rss-dsc/
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This is result from our M&M RSS simulation. There are 300 datasets, each with 1000 SNPs. Per signal PVE is 0.05.
For each dataset, we simulate signals using 2 type of priors:
The detail about prior is here.
The oracle residual variance is a diagonal matrix.
The detail about prior is here.
The oracle residual variance is a dense matrix.
We estimate prior weights using ‘EM’ method.
Overall: Ignoring correlation between conditions in residual matrix results in poor fit.
Artificial Mixture
GTEx Mixture
Artificial Mixture
GTEx Mixture
Artificial Mixture
GTEx Mixture