mvSuSiE RSS ukb

Last updated: 2021-03-16

Checks: 2 0

Knit directory: mmbr-rss-dsc/

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html	38a8e4e	zouyuxin	2021-03-16	Build site.
Rmd	a7a9c47	zouyuxin	2021-03-16	wflow_publish(“analysis/mmbr_rss_ukb_simulation_20210313.Rmd”)

This is result from our mvSuSiE RSS simulation using UKB data. There are 600 datasets. The max PVE across traits is 0.0005.

For each dataset, we simulate signals using 2 type of priors, the details are here

Artificial mixture: 20 conditions. The oracle residual variance is a diagonal matrix.
UKB Bloodcells mixture: 16 conditions. The oracle residual variance is a dense matrix.

We estimate prior weights using ‘EM’ method.

Comparing with previous simulation 20210107, we add a small diagonal to ED priors.