PICRUSt Stratified Analyses

Fusobacterium nucleatum

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Last updated: 2021-05-20

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Knit directory: esoph-micro-cancer-workflow/

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Rmd	5a00a1b	noah-padgett	2021-04-29	updated figured and stuff
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Rmd	2072df5	noah-padgett	2021-04-22	fixed the issue picrust analysis code
html	2072df5	noah-padgett	2021-04-22	fixed the issue picrust analysis code
Rmd	ea63e54	noah-padgett	2021-04-15	updated picrust results
html	ea63e54	noah-padgett	2021-04-15	updated picrust results

---

i. Mean relative abundance in Tumors

ii. Standard error of mean in Tumors

iii. Mean relative abundance in Non-tumors

iv. Standard error of mean in Non-tumors

v. GLM differential abundance analysis between Tumor vs Non-tumor (Patient=Fixed effect)
  1. P-value
  2. FDR corrected q-value
vi. GLMM differential abundance analysis between Tumor vs Non-tumor (Patient=Random Effect)
  1.P-value
  2. FDR corrected q-value

Part 1 EC Data

# note: must rename function to func (or something else) because "function" is a reserved name in R and can't be used.

descriptions <- readr::read_tsv("data/PICRUST/ec_pred_metagenome_unstrat_descrip.tsv")[,1:2] %>%
  distinct()

-- Column specification --------------------------------------------------------
cols(
  .default = col_double(),
  `function` = col_character(),
  description = col_character()
)
i Use `spec()` for the full column specifications.

colnames(descriptions) <- c("func", "description")

pi.dat <- readxl::read_xlsx("data/PICRUST-Stratified/EC_fuso.xlsx")
colnames(pi.dat) <- c("func",  colnames(pi.dat)[-c(1)])

# add descriptions to dataframe
pi.dat <- left_join(pi.dat, descriptions, by="func")
pi.dat <- pi.dat[,c(1,161,3:160)]
# aggreagate
pi.dat<- pi.dat %>%
  group_by(description) %>%
  summarise(across(`1.S37.Jun172016`:`99.D01.S37.Jun232016`,.fns = sum))
# long format
pi.dat <- pi.dat %>%
  pivot_longer(
    cols=`1.S37.Jun172016`:`99.D01.S37.Jun232016`,
    names_to = "ID",
    values_to = "Abundance"
  )
d <- as.data.frame(dat.16s)
mydata <- full_join(pi.dat, d)

Joining, by = "ID"

Warning in class(x) <- c(setdiff(subclass, tibble_class), tibble_class): Setting
class(x) to multiple strings ("tbl_df", "tbl", ...); result will no longer be an
S4 object

mydata <- mydata %>%
  mutate(
    ID.n = as.numeric(as.factor(ID)),
    description.n = as.numeric(as.factor(description))
  ) %>%
  group_by(ID) %>%
  mutate(
    dem = ifelse(sum(Abundance)==0, 1, sum(Abundance)),
    RelAbundance = Abundance/dem*100) %>%
  ungroup()%>%
  group_by(description)%>%
  mutate(avgRA = mean(RelAbundance))

Abundance

I needed to change from relative abundance to abundance due to so many individuals having 0 counts for all descriptions.

# Test-1
d <- mydata %>%
  filter(description=="Arsenite-transporting ATPase")
fit1 <- t.test(d$RelAbundance ~ d$tumor.cat)
fit1

    Welch Two Sample t-test

data:  d$RelAbundance by d$tumor.cat
t = -1.6, df = 127, p-value = 0.11
alternative hypothesis: true difference in means is not equal to 0
95 percent confidence interval:
 -0.0809126  0.0086127
sample estimates:
mean in group Non-Tumor     mean in group Tumor 
               0.068288                0.104438 

fit1$stderr 

[1] 0.02262

# Test-2
d <- mydata %>%
  filter(description=="Gamma-glutamyltransferase")
fit2 <- t.test(d$RelAbundance ~ d$tumor.cat)
fit2

    Welch Two Sample t-test

data:  d$RelAbundance by d$tumor.cat
t = -1.6, df = 127, p-value = 0.11
alternative hypothesis: true difference in means is not equal to 0
95 percent confidence interval:
 -0.0809126  0.0086127
sample estimates:
mean in group Non-Tumor     mean in group Tumor 
               0.068288                0.104438 

fit2$stderr

[1] 0.02262

# Run on all descriptions
tb.ra1 <- mydata %>%
  group_by(description) %>%
  summarise(ng = n(),
            Overall.M = mean(RelAbundance),
            Overall.SE = sd(RelAbundance)/sqrt(ng))
tb.ra2m <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(M = mean(RelAbundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = M)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2se <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(),SE = sd(RelAbundance)/sqrt(ng)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = SE)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2var <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(), VAR = var(RelAbundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = VAR)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2ng <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n()) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = ng)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra <- left_join(tb.ra1, tb.ra2m)

Joining, by = "description"

tb.ra <- cbind(tb.ra, tb.ra2se[,-1])
tb.ra <- cbind(tb.ra, tb.ra2var[,-1])
tb.ra <- cbind(tb.ra, tb.ra2ng[,-1]) 

colnames(tb.ra) <- c("description", "ng", "Overall Mean", "Overall SE", "Non-Tumor Mean", "Tumor Mean", "Non-Tumor SE", "Tumor SE","Non-Tumor Var", "Tumor Var", "Non-Tumor Ng", "Tumor Ng")
tb.ra <- tb.ra %>%
  arrange(desc(`Overall Mean`))
tb.ra <- tb.ra[, c("description", "Overall Mean", "Overall SE","Tumor Mean","Tumor Var", "Tumor SE","Tumor Ng", "Non-Tumor Mean","Non-Tumor Var", "Non-Tumor SE", "Non-Tumor Ng")]

# compute t-test
tb.ra <- tb.ra %>%
  mutate(
    SEpooled = sqrt(`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`),
    t = (`Tumor Mean` - `Non-Tumor Mean`)/(SEpooled),
    df = ((`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`)**2)/(((`Tumor Var`/`Tumor Ng`)**2)/(`Tumor Ng`-1) + ((`Non-Tumor Var`/`Non-Tumor Ng`)**2)/(`Non-Tumor Ng`-1)),
    p = pt(q = abs(t), df=df, lower.tail = F)*2,
    fdr_p = p.adjust(p, method="fdr")
  )



kable(tb.ra, format="html", digits=5, caption="Stratefied EC Data - Fusobacterium nucleatum: Average RelAbundance of Each Description (sorted in descending order)") %>%
  kable_styling(full_width = T) %>%
  scroll_box(width = "100%", height="600px")

Stratefied EC Data - Fusobacterium nucleatum: Average RelAbundance of Each Description (sorted in descending order)

description	Overall Mean	Overall SE	Tumor Mean	Tumor Var	Tumor SE	Tumor Ng	Non-Tumor Mean	Non-Tumor Var	Non-Tumor SE	Non-Tumor Ng	SEpooled	t	df	p	fdr_p
DNA helicase	0.71460	0.06564	0.86696	0.69643	0.10351	65	0.60812	0.64941	0.08356	93	0.13303	1.94569	134.781	0.05377	0.07807
DNA-directed DNA polymerase	0.67302	0.06188	0.81474	0.61604	0.09735	65	0.57398	0.57984	0.07896	93	0.12535	1.92074	135.200	0.05687	0.08012
Iron-chelate-transporting ATPase	0.42826	0.04062	0.52671	0.27497	0.06504	65	0.35945	0.24186	0.05100	93	0.08265	2.02377	132.136	0.04501	0.07807
Protein-N(pi)-phosphohistidine–sugar phosphotransferase	0.37326	0.03727	0.43199	0.19715	0.05507	65	0.33221	0.23315	0.05007	93	0.07443	1.34044	144.735	0.18220	0.22805
Peptidylprolyl isomerase	0.34260	0.03169	0.42204	0.16647	0.05061	65	0.28707	0.14747	0.03982	93	0.06440	2.09591	132.462	0.03799	0.07807
Pyruvate synthase	0.30924	0.03254	0.38227	0.18264	0.05301	65	0.25820	0.15206	0.04044	93	0.06667	1.86092	129.623	0.06502	0.09027
DNA-directed RNA polymerase	0.28584	0.02626	0.34678	0.11143	0.04140	65	0.24325	0.10391	0.03343	93	0.05321	1.94569	134.781	0.05377	0.07807
Type I site-specific deoxyribonuclease	0.27911	0.02657	0.34764	0.11888	0.04277	65	0.23121	0.10204	0.03312	93	0.05409	2.15241	131.023	0.03320	0.07807
Site-specific DNA-methyltransferase (adenine-specific)	0.26914	0.02570	0.32858	0.10967	0.04108	65	0.22760	0.09754	0.03239	93	0.05231	1.93044	132.645	0.05569	0.07865
Coproporphyrinogen dehydrogenase	0.22658	0.02097	0.27129	0.06878	0.03253	65	0.19534	0.06830	0.02710	93	0.04234	1.79397	137.567	0.07501	0.10339
Acetate CoA-transferase	0.22608	0.02227	0.27783	0.08371	0.03589	65	0.18991	0.07225	0.02787	93	0.04544	1.93483	131.275	0.05516	0.07810
Butyrate–acetoacetate CoA-transferase	0.22608	0.02227	0.27783	0.08371	0.03589	65	0.18991	0.07225	0.02787	93	0.04544	1.93483	131.275	0.05516	0.07810
Cob(I)yrinic acid a,c-diamide adenosyltransferase	0.21736	0.02066	0.27192	0.07193	0.03327	65	0.17922	0.06152	0.02572	93	0.04205	2.20469	130.859	0.02922	0.07807
Asparaginyl-tRNA synthase (glutamine-hydrolyzing)	0.21438	0.01969	0.26009	0.06268	0.03105	65	0.18244	0.05845	0.02507	93	0.03991	1.94569	134.781	0.05377	0.07807
Glutaminyl-tRNA synthase (glutamine-hydrolyzing)	0.21438	0.01969	0.26009	0.06268	0.03105	65	0.18244	0.05845	0.02507	93	0.03991	1.94569	134.781	0.05377	0.07807
Shikimate dehydrogenase	0.21388	0.02196	0.26662	0.08234	0.03559	65	0.17701	0.06942	0.02732	93	0.04487	1.99724	130.200	0.04788	0.07807
Cystathionine beta-lyase	0.20468	0.01901	0.24911	0.05873	0.03006	65	0.17362	0.05419	0.02414	93	0.03855	1.95823	134.304	0.05228	0.07807
H(+)-transporting two-sector ATPase	0.20468	0.01901	0.24911	0.05873	0.03006	65	0.17362	0.05419	0.02414	93	0.03855	1.95823	134.304	0.05228	0.07807
Exodeoxyribonuclease VII	0.20218	0.01880	0.24888	0.05862	0.03003	65	0.16953	0.05190	0.02362	93	0.03821	2.07673	132.436	0.03976	0.07807
Histidine kinase	0.19471	0.01935	0.23005	0.05750	0.02974	65	0.17001	0.05948	0.02529	93	0.03904	1.53779	139.334	0.12637	0.16243
Cysteine–tRNA ligase	0.18997	0.01835	0.23768	0.05660	0.02951	65	0.15663	0.04865	0.02287	93	0.03733	2.17076	131.090	0.03175	0.07807
N-acetylmuramoyl-L-alanine amidase	0.18798	0.01840	0.23091	0.05753	0.02975	65	0.15797	0.04906	0.02297	93	0.03758	1.94054	130.728	0.05447	0.07810
Non-specific serine/threonine protein kinase	0.18700	0.01768	0.22584	0.05052	0.02788	65	0.15985	0.04732	0.02256	93	0.03586	1.84008	134.984	0.06795	0.09389
Inorganic diphosphatase	0.18450	0.01744	0.22561	0.05040	0.02785	65	0.15577	0.04492	0.02198	93	0.03547	1.96885	132.742	0.05105	0.07807
Long-chain-fatty-acid–CoA ligase	0.18450	0.01744	0.22561	0.05040	0.02785	65	0.15577	0.04492	0.02198	93	0.03547	1.96885	132.742	0.05105	0.07807
Short-chain acyl-CoA dehydrogenase	0.18450	0.01744	0.22561	0.05040	0.02785	65	0.15577	0.04492	0.02198	93	0.03547	1.96885	132.742	0.05105	0.07807
DNA-(apurinic or apyrimidinic site) lyase	0.17827	0.01758	0.21993	0.05288	0.02852	65	0.14916	0.04443	0.02186	93	0.03593	1.96968	130.040	0.05100	0.07807
Ribosomal-protein-alanine N-acetyltransferase	0.17230	0.01695	0.21440	0.04853	0.02732	65	0.14287	0.04160	0.02115	93	0.03455	2.07041	130.959	0.04038	0.07807
Acetyl-CoA carboxylase	0.15512	0.01449	0.18460	0.03227	0.02228	65	0.13453	0.03310	0.01886	93	0.02919	1.71514	138.970	0.08855	0.11946
Monosaccharide-transporting ATPase	0.15263	0.01417	0.18437	0.03219	0.02225	65	0.13044	0.03055	0.01812	93	0.02870	1.87886	135.569	0.06241	0.08686
Cysteine synthase	0.14590	0.01444	0.18523	0.03518	0.02327	65	0.11841	0.02988	0.01792	93	0.02937	2.27525	130.525	0.02452	0.07807
[Formate-C-acetyltransferase]-activating enzyme	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
23S rRNA pseudouridine(1911/1915/1917) synthase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Adenosylcobyric acid synthase (glutamine-hydrolyzing)	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
ADP-ribose diphosphatase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Alanine–tRNA ligase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Alanine racemase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Beta-lysine 5,6-aminomutase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Carbamoyl-phosphate synthase (glutamine-hydrolyzing)	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
D-lactate dehydrogenase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
DNA topoisomerase (ATP-hydrolyzing)	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
dTDP-glucose 4,6-dehydratase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Fructose-bisphosphatase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Glucose-1-phosphate adenylyltransferase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Glutaconate CoA-transferase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Glycerol-3-phosphate 1-O-acyltransferase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Glycine–tRNA ligase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
GTP diphosphokinase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
N(6)-L-threonylcarbamoyladenine synthase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Oxaloacetate decarboxylase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Phenylalanine–tRNA ligase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Ribonucleoside-diphosphate reductase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Thioredoxin-disulfide reductase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Transketolase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
UDP-glucose 4-epimerase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Xaa-Pro aminopeptidase	0.14292	0.01313	0.17339	0.02786	0.02070	65	0.12162	0.02598	0.01671	93	0.02661	1.94569	134.781	0.05377	0.07807
Fe(3+)-transporting ATPase	0.14042	0.01297	0.17316	0.02778	0.02067	65	0.11754	0.02472	0.01630	93	0.02633	2.11243	132.664	0.03652	0.07807
Methylaspartate mutase	0.14042	0.01297	0.17316	0.02778	0.02067	65	0.11754	0.02472	0.01630	93	0.02633	2.11243	132.664	0.03652	0.07807
Peptide-methionine (S)-S-oxide reductase	0.14042	0.01297	0.17316	0.02778	0.02067	65	0.11754	0.02472	0.01630	93	0.02633	2.11243	132.664	0.03652	0.07807
1-deoxy-D-xylulose-5-phosphate synthase	0.13322	0.01252	0.16242	0.02557	0.01983	65	0.11281	0.02349	0.01589	93	0.02541	1.95209	134.105	0.05301	0.07807
CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase	0.13322	0.01252	0.16242	0.02557	0.01983	65	0.11281	0.02349	0.01589	93	0.02541	1.95209	134.105	0.05301	0.07807
Phosphatidate cytidylyltransferase	0.13322	0.01252	0.16242	0.02557	0.01983	65	0.11281	0.02349	0.01589	93	0.02541	1.95209	134.105	0.05301	0.07807
8-oxo-dGTP diphosphatase	0.13072	0.01234	0.16219	0.02549	0.01980	65	0.10872	0.02216	0.01544	93	0.02511	2.12931	131.607	0.03509	0.07807
Adenine phosphoribosyltransferase	0.13072	0.01234	0.16219	0.02549	0.01980	65	0.10872	0.02216	0.01544	93	0.02511	2.12931	131.607	0.03509	0.07807
Beta-ketoacyl-[acyl-carrier-protein] synthase III	0.13072	0.01234	0.16219	0.02549	0.01980	65	0.10872	0.02216	0.01544	93	0.02511	2.12931	131.607	0.03509	0.07807
dTDP-4-dehydrorhamnose 3,5-epimerase	0.13072	0.01234	0.16219	0.02549	0.01980	65	0.10872	0.02216	0.01544	93	0.02511	2.12931	131.607	0.03509	0.07807
Glycerophosphodiester phosphodiesterase	0.13072	0.01234	0.16219	0.02549	0.01980	65	0.10872	0.02216	0.01544	93	0.02511	2.12931	131.607	0.03509	0.07807
Lactoylglutathione lyase	0.13072	0.01234	0.16219	0.02549	0.01980	65	0.10872	0.02216	0.01544	93	0.02511	2.12931	131.607	0.03509	0.07807
Peptide-methionine (R)-S-oxide reductase	0.13072	0.01234	0.16219	0.02549	0.01980	65	0.10872	0.02216	0.01544	93	0.02511	2.12931	131.607	0.03509	0.07807
Thiamine-phosphate diphosphorylase	0.13072	0.01234	0.16219	0.02549	0.01980	65	0.10872	0.02216	0.01544	93	0.02511	2.12931	131.607	0.03509	0.07807
Uracil phosphoribosyltransferase	0.13072	0.01234	0.16219	0.02549	0.01980	65	0.10872	0.02216	0.01544	93	0.02511	2.12931	131.607	0.03509	0.07807
Aminodeoxychorismate synthase	0.12822	0.01237	0.16196	0.02542	0.01978	65	0.10464	0.02220	0.01545	93	0.02509	2.28402	131.811	0.02397	0.07807
Ethanolamine ammonia-lyase	0.11851	0.01224	0.15098	0.02516	0.01968	65	0.09582	0.02165	0.01526	93	0.02490	2.21545	131.128	0.02845	0.07807
Nickel-transporting ATPase	0.11851	0.01224	0.15098	0.02516	0.01968	65	0.09582	0.02165	0.01526	93	0.02490	2.21545	131.128	0.02845	0.07807
Endopeptidase La	0.11304	0.01113	0.13891	0.02093	0.01794	65	0.09496	0.01806	0.01394	93	0.02272	1.93483	131.275	0.05516	0.07810
Heptaprenyl diphosphate synthase	0.11304	0.01113	0.13891	0.02093	0.01794	65	0.09496	0.01806	0.01394	93	0.02272	1.93483	131.275	0.05516	0.07810
Histidine ammonia-lyase	0.11304	0.01113	0.13891	0.02093	0.01794	65	0.09496	0.01806	0.01394	93	0.02272	1.93483	131.275	0.05516	0.07810
Imidazolonepropionase	0.11304	0.01113	0.13891	0.02093	0.01794	65	0.09496	0.01806	0.01394	93	0.02272	1.93483	131.275	0.05516	0.07810
Phosphoribosylglycinamide formyltransferase	0.11304	0.01113	0.13891	0.02093	0.01794	65	0.09496	0.01806	0.01394	93	0.02272	1.93483	131.275	0.05516	0.07810
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	0.11304	0.01113	0.13891	0.02093	0.01794	65	0.09496	0.01806	0.01394	93	0.02272	1.93483	131.275	0.05516	0.07810
Urocanate hydratase	0.11304	0.01113	0.13891	0.02093	0.01794	65	0.09496	0.01806	0.01394	93	0.02272	1.93483	131.275	0.05516	0.07810
Lactaldehyde reductase	0.11054	0.01114	0.13868	0.02085	0.01791	65	0.09087	0.01799	0.01391	93	0.02268	2.10844	131.261	0.03689	0.07807
Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)	0.10334	0.01104	0.12794	0.02083	0.01790	65	0.08614	0.01762	0.01376	93	0.02258	1.85113	130.331	0.06642	0.09198
Polar-amino-acid-transporting ATPase	0.10134	0.01002	0.12117	0.01609	0.01573	65	0.08748	0.01541	0.01287	93	0.02033	1.65744	135.998	0.09974	0.13360
Ribonuclease H	0.10134	0.01002	0.12117	0.01609	0.01573	65	0.08748	0.01541	0.01287	93	0.02033	1.65744	135.998	0.09974	0.13360
Cystathionine gamma-synthase	0.10084	0.01103	0.12771	0.02075	0.01787	65	0.08205	0.01747	0.01371	93	0.02252	2.02730	130.139	0.04467	0.07807
Formimidoyltetrahydrofolate cyclodeaminase	0.10084	0.01103	0.12771	0.02075	0.01787	65	0.08205	0.01747	0.01371	93	0.02252	2.02730	130.139	0.04467	0.07807
Glutamate formimidoyltransferase	0.10084	0.01103	0.12771	0.02075	0.01787	65	0.08205	0.01747	0.01371	93	0.02252	2.02730	130.139	0.04467	0.07807
Glutamate racemase	0.09884	0.00976	0.12094	0.01605	0.01572	65	0.08340	0.01395	0.01225	93	0.01992	1.88448	131.566	0.06171	0.08672
Acetolactate synthase	0.09634	0.00976	0.12071	0.01603	0.01570	65	0.07931	0.01384	0.01220	93	0.01989	2.08188	131.283	0.03930	0.07807
Chorismate mutase	0.09337	0.00982	0.10888	0.01439	0.01488	65	0.08253	0.01570	0.01299	93	0.01976	1.33357	141.545	0.18449	0.23041
Arsenate reductase (glutaredoxin)	0.08914	0.00879	0.10997	0.01322	0.01426	65	0.07458	0.01111	0.01093	93	0.01797	1.96968	130.040	0.05100	0.07807
Crossover junction endodeoxyribonuclease	0.08914	0.00879	0.10997	0.01322	0.01426	65	0.07458	0.01111	0.01093	93	0.01797	1.96968	130.040	0.05100	0.07807
Cysteine desulfurase	0.08914	0.00879	0.10997	0.01322	0.01426	65	0.07458	0.01111	0.01093	93	0.01797	1.96968	130.040	0.05100	0.07807
DNA topoisomerase	0.08914	0.00879	0.10997	0.01322	0.01426	65	0.07458	0.01111	0.01093	93	0.01797	1.96968	130.040	0.05100	0.07807
Homoserine kinase	0.08914	0.00879	0.10997	0.01322	0.01426	65	0.07458	0.01111	0.01093	93	0.01797	1.96968	130.040	0.05100	0.07807
Kdo(2)-lipid IV(A) lauroyltransferase	0.08914	0.00879	0.10997	0.01322	0.01426	65	0.07458	0.01111	0.01093	93	0.01797	1.96968	130.040	0.05100	0.07807
Phosphate acetyltransferase	0.08914	0.00879	0.10997	0.01322	0.01426	65	0.07458	0.01111	0.01093	93	0.01797	1.96968	130.040	0.05100	0.07807
Threonine ammonia-lyase	0.08914	0.00879	0.10997	0.01322	0.01426	65	0.07458	0.01111	0.01093	93	0.01797	1.96968	130.040	0.05100	0.07807
Repressor LexA	0.08664	0.00877	0.10974	0.01319	0.01425	65	0.07049	0.01093	0.01084	93	0.01790	2.19214	129.401	0.03016	0.07807
Tryptophanase	0.08664	0.00877	0.10974	0.01319	0.01425	65	0.07049	0.01093	0.01084	93	0.01790	2.19214	129.401	0.03016	0.07807
2-iminoacetate synthase	0.08366	0.00814	0.09790	0.00968	0.01220	65	0.07371	0.01088	0.01082	93	0.01631	1.48333	142.764	0.14019	0.17899
Biotin synthase	0.08366	0.00814	0.09790	0.00968	0.01220	65	0.07371	0.01088	0.01082	93	0.01631	1.48333	142.764	0.14019	0.17899
Phosphoglycerate mutase (2,3-diphosphoglycerate-independent)	0.08366	0.00814	0.09790	0.00968	0.01220	65	0.07371	0.01088	0.01082	93	0.01631	1.48333	142.764	0.14019	0.17899
Arsenite-transporting ATPase	0.08316	0.01094	0.10444	0.02154	0.01820	65	0.06829	0.01677	0.01343	93	0.02262	1.59813	126.533	0.11251	0.14494
Gamma-glutamyltransferase	0.08316	0.01094	0.10444	0.02154	0.01820	65	0.06829	0.01677	0.01343	93	0.02262	1.59813	126.533	0.11251	0.14494
Glutathione hydrolase	0.08316	0.01094	0.10444	0.02154	0.01820	65	0.06829	0.01677	0.01343	93	0.02262	1.59813	126.533	0.11251	0.14494
dTDP-4-dehydrorhamnose reductase	0.08116	0.00778	0.09767	0.00964	0.01218	65	0.06963	0.00930	0.01000	93	0.01576	1.77936	136.298	0.07741	0.10468
Fructose-bisphosphate aldolase	0.08116	0.00778	0.09767	0.00964	0.01218	65	0.06963	0.00930	0.01000	93	0.01576	1.77936	136.298	0.07741	0.10468
Glucokinase	0.08116	0.00778	0.09767	0.00964	0.01218	65	0.06963	0.00930	0.01000	93	0.01576	1.77936	136.298	0.07741	0.10468
Orotidine-5’-phosphate decarboxylase	0.08116	0.00778	0.09767	0.00964	0.01218	65	0.06963	0.00930	0.01000	93	0.01576	1.77936	136.298	0.07741	0.10468
Phosphoenolpyruvate–protein phosphotransferase	0.08116	0.00778	0.09767	0.00964	0.01218	65	0.06963	0.00930	0.01000	93	0.01576	1.77936	136.298	0.07741	0.10468
Pyridoxal 5’-phosphate synthase (glutamine hydrolyzing)	0.08116	0.00778	0.09767	0.00964	0.01218	65	0.06963	0.00930	0.01000	93	0.01576	1.77936	136.298	0.07741	0.10468
tRNA (guanine(46)-N(7))-methyltransferase	0.08116	0.00778	0.09767	0.00964	0.01218	65	0.06963	0.00930	0.01000	93	0.01576	1.77936	136.298	0.07741	0.10468
UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase	0.08116	0.00778	0.09767	0.00964	0.01218	65	0.06963	0.00930	0.01000	93	0.01576	1.77936	136.298	0.07741	0.10468
Fumarate reductase (quinol)	0.07867	0.00775	0.09744	0.00961	0.01216	65	0.06555	0.00909	0.00988	93	0.01567	2.03537	135.393	0.04376	0.07807
(2E,6E)-farnesyl diphosphate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
(FADH(2)-oxidizing)	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
[Acyl-carrier-protein] S-malonyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
1-deoxy-D-xylulose-5-phosphate reductoisomerase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
1-phosphofructokinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
1,4-alpha-glucan branching enzyme	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
16S rRNA (cytidine(1402)-2’-O)-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
16S rRNA (cytidine(1409)-2’-O)-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
16S rRNA (cytosine(1402)-N(4))-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
16S rRNA (cytosine(967)-C(5))-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
16S rRNA (guanine(1207)-N(2))-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
16S rRNA (guanine(527)-N(7))-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
16S rRNA (uracil(1498)-N(3))-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
16S rRNA pseudouridine(516) synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
2-iminobutanoate/2-iminopropanoate deaminase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
23S rRNA (adenine(2503)-C(2))-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
23S rRNA (cytidine(1920)-2’-O)-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
23S rRNA (cytosine(1962)-C(5))-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
23S rRNA (guanosine(2251)-2’-O)-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
23S rRNA (pseudouridine(1915)-N(3))-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
23S rRNA (uracil(1939)-C(5))-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
23S rRNA pseudouridine(2605) synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
23S rRNA pseudouridine(955/2504/2580) synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
3’(2’),5’-bisphosphate nucleotidase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
3-aminobutyryl-CoA ammonia-lyase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
3-dehydroquinate dehydratase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
3-deoxy-7-phosphoheptulonate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
3-deoxy-8-phosphooctulonate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
3-deoxy-manno-octulosonate-8-phosphatase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
3-deoxy-manno-octulosonate cytidylyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
3-hydroxyacyl-[acyl-carrier-protein] dehydratase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
3-hydroxybutyryl-CoA dehydrogenase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
3-oxoacyl-[acyl-carrier-protein] reductase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
3-phosphoshikimate 1-carboxyvinyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
3,4-dihydroxy-2-butanone-4-phosphate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
4-alpha-glucanotransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
5-(carboxyamino)imidazole ribonucleotide mutase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
5-amino-6-(5-phosphoribosylamino)uracil reductase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
5-formyltetrahydrofolate cyclo-ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
6-phosphofructokinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
6,7-dimethyl-8-ribityllumazine synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
8-amino-7-oxononanoate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Acetate kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Acetyl-CoA C-acetyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
acetylglucosaminyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Acyl-[acyl-carrier-protein]–UDP-N-acetylglucosamine O-acyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Acylaminoacyl-peptidase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Adenosylcobalamin/alpha-ribazole phosphatase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Adenosylcobinamide-GDP ribazoletransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Adenosylcobinamide-phosphate guanylyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Adenosylcobinamide-phosphate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Adenosylcobinamide kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Adenosylhomocysteine nucleosidase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Adenosylmethionine–8-amino-7-oxononanoate transaminase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Adenylate kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Adenylosuccinate lyase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Adenylosuccinate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
ADP-glyceromanno-heptose 6-epimerase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Aldose 1-epimerase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Amidophosphoribosyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Aminoacyl-tRNA hydrolase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Arabinose-5-phosphate isomerase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Arginine–tRNA ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Aromatic-amino-acid transaminase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Asparaginase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Asparagine–tRNA ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Aspartate–ammonia ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Aspartate–tRNA ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Aspartate carbamoyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Aspartate transaminase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Beta-ketoacyl-[acyl-carrier-protein] synthase II	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Biotin–[acetyl-CoA-carboxylase] ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
C-terminal processing peptidase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Cadmium-exporting ATPase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Caffeoyl-CoA O-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Calcium-transporting ATPase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Carboxypeptidase Taq	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
CCA tRNA nucleotidyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
CDP-diacylglycerol–serine O-phosphatidyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Chorismate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Citrate CoA-transferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Citryl-CoA lyase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Cobalt-factor II C(20)-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Cobalt-precorrin-4 methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Cobalt-precorrin-5B (C(1))-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Cobalt-precorrin-6A reductase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Cobalt-precorrin-6B (C(15))-methyltransferase (decarboxylating)	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Cobalt-precorrin-7 (C(5))-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Cobalt-precorrin-8 methylmutase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Cobalt-precorrin 5A hydrolase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Cobyrinate a,c-diamide synthase (glutamine-hydrolyzing)	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Cu(+) exporting ATPase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
D-alanine–D-alanine ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
D-sedoheptulose 7-phosphate isomerase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
dCMP deaminase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Dephospho-CoA kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Dethiobiotin synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Diadenylate cyclase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Diaminohydroxyphosphoribosylaminopyrimidine deaminase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Dihydrofolate reductase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Dihydrofolate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Dihydroneopterin aldolase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Dihydroorotase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Dihydroorotate dehydrogenase (NAD(+))	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Dihydropteroate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Dimethylallyltranstransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
diphosphate specific)	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
DNA ligase (NAD(+))	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
dTMP kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
dUTP diphosphatase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Endopeptidase Clp	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Enoyl-[acyl-carrier-protein] reductase (NADH)	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Enoyl-CoA hydratase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Exodeoxyribonuclease III	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Exopolyphosphatase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
FAD synthetase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Formate–tetrahydrofolate ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Formate C-acetyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Formimidoylglutamase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Galactokinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Geranylgeranyl diphosphate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glucosamine-1-phosphate N-acetyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glucosamine-6-phosphate deaminase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glucose-6-phosphate isomerase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glutaconyl-CoA decarboxylase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glutamate–tRNA ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glutamate-1-semialdehyde 2,1-aminomutase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glutamate dehydrogenase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glutaminase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glutamine–fructose-6-phosphate transaminase (isomerizing)	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glutamyl-tRNA reductase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glutathione peroxidase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glycerol-3-phosphate cytidylyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glycerol-3-phosphate dehydrogenase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glycerol-3-phosphate dehydrogenase (NAD(P)(+))	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glycerol kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Glycogen phosphorylase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
GMP synthase (glutamine-hydrolyzing)	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
GTP cyclohydrolase I	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
GTP cyclohydrolase II	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Guanosine-3’,5’-bis(diphosphate) 3’-diphosphatase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Guanosine-5’-triphosphate,3’-diphosphate diphosphatase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Guanylate kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Histidine–tRNA ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Histidinol-phosphatase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Holo-[acyl-carrier-protein] synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Hydroxyacylglutathione hydrolase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Hydroxylamine reductase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Hydroxymethylbilane synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Hydroxymethylpyrimidine kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Hypoxanthine phosphoribosyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
IMP cyclohydrolase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
IMP dehydrogenase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Isoleucine–tRNA ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
L-aspartate oxidase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
L-erythro-3,5-diaminohexanoate dehydrogenase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
L-lactate dehydrogenase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
L-serine ammonia-lyase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
L-threonine aldolase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
L-threonylcarbamoyladenylate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Leucine–tRNA ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Leucyl aminopeptidase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Lipid-A-disaccharide synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Lysine–tRNA ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Lysine 2,3-aminomutase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Malonyl-[acyl-carrier protein] O-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Methenyltetrahydrofolate cyclohydrolase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Methionine–tRNA ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Methionine adenosyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Methionine gamma-lyase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Methionine synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Methionyl-tRNA formyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Methionyl aminopeptidase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Methylated-DNA–[protein]-cysteine S-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Methylenetetrahydrofolate dehydrogenase (NADP(+))	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
N-acetylglucosamine-6-phosphate deacetylase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
N-acetylneuraminate lyase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
N-acylglucosamine-6-phosphate 2-epimerase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
NAD(+) kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
NAD(+) synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Nicotinamide-nucleotide amidase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Nicotinate-nucleotide adenylyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Nicotinate-nucleotide diphosphorylase (carboxylating)	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Nicotinate phosphoribosyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Oligonucleotidase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Orotate phosphoribosyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Pantetheine-phosphate adenylyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Pantothenate kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Peptide chain release factor N(5)-glutamine methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Peptide deformylase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Peroxiredoxin	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphatidylglycerophosphatase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphatidylserine decarboxylase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phospho-N-acetylmuramoyl-pentapeptide-transferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphoglucosamine mutase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphoglycerate kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphomethylpyrimidine kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphomethylpyrimidine synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphopantothenate–cysteine ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphopantothenoylcysteine decarboxylase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphopyruvate hydratase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphoribosylamine–glycine ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphoribosylaminoimidazolecarboxamide formyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphoribosylaminoimidazolesuccinocarboxamide synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphoribosylformylglycinamidine cyclo-ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphoribosylformylglycinamidine synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Phosphoserine phosphatase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Pimeloyl-[acyl-carrier protein] methyl ester esterase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Polyamine-transporting ATPase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Polyribonucleotide nucleotidyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Porphobilinogen synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Precorrin-2 C(20)-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Precorrin-2 dehydrogenase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Precorrin-3B C(17)-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Precorrin-4 C(11)-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Precorrin-6A reductase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Precorrin-8X methylmutase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Prepilin peptidase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Proline–tRNA ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Purine-nucleoside phosphorylase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Pyroglutamyl-peptidase I	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Pyruvate kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Pyruvate, phosphate dikinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Quinolinate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Riboflavin kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Riboflavin synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Ribonuclease III	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Ribonuclease M5	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Ribonuclease P	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Ribonucleoside-triphosphate reductase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Ribose-5-phosphate isomerase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Ribose-phosphate diphosphokinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Ribulose-phosphate 3-epimerase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
RNA helicase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
S-adenosylmethionine:tRNA ribosyltransferase-isomerase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Serine–tRNA ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Serine-type D-Ala-D-Ala carboxypeptidase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Shikimate kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Signal peptidase I	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Signal peptidase II	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Sirohydrochlorin cobaltochelatase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Sirohydrochlorin ferrochelatase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Spore photoproduct lyase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Starch synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Succinyl-diaminopimelate desuccinylase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Sulfur carrier protein ThiS adenylyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Tetraacyldisaccharide 4’-kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Tetrahydrofolate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Thiamine diphosphokinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Thiazole synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Threonine–tRNA ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Threonine-phosphate decarboxylase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Thymidylate synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Triose-phosphate isomerase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Tripeptide aminopeptidase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
tRNA-guanine(34) transglycosylase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
tRNA (cytidine(34)-2’-O)-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
tRNA (guanine(37)-N(1))-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
tRNA dimethylallyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
tRNA pseudouridine(38-40) synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
tRNA pseudouridine(55) synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
tRNA(Ile)-lysidine synthetase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Tryptophan–tRNA ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Tyrosine–tRNA ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
UDP-3-O-acyl-N-acetylglucosamine deacetylase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
UDP-glucose–hexose-1-phosphate uridylyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
UDP-N-acetylglucosamine diphosphorylase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
UDP-N-acetylmuramate–L-alanine ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
UDP-N-acetylmuramate dehydrogenase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
UDP-N-acetylmuramoyl-L-alanine–D-glutamate ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
UMP kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
UMP/CMP kinase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Undecaprenyl-diphosphate phosphatase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Uracil-DNA glycosylase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Uroporphyrinogen-III C-methyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Uroporphyrinogen-III synthase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
UTP–glucose-1-phosphate uridylyltransferase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Valine–tRNA ligase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Xaa-Pro dipeptidase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
Zinc-exporting ATPase	0.07146	0.00656	0.08670	0.00696	0.01035	65	0.06081	0.00649	0.00836	93	0.01330	1.94569	134.781	0.05377	0.07807
[Citrate (pro-3S)-lyase] ligase	0.06896	0.00650	0.08647	0.00693	0.01033	65	0.05673	0.00621	0.00817	93	0.01317	2.25856	132.970	0.02554	0.07807
2.7.11.30 and 2.7.12.1	0.06896	0.00650	0.08647	0.00693	0.01033	65	0.05673	0.00621	0.00817	93	0.01317	2.25856	132.970	0.02554	0.07807
Aminodeoxychorismate lyase	0.06896	0.00650	0.08647	0.00693	0.01033	65	0.05673	0.00621	0.00817	93	0.01317	2.25856	132.970	0.02554	0.07807
Beta-lactamase	0.06896	0.00650	0.08647	0.00693	0.01033	65	0.05673	0.00621	0.00817	93	0.01317	2.25856	132.970	0.02554	0.07807
Citrate lyase holo-[acyl-carrier protein] synthase	0.06896	0.00650	0.08647	0.00693	0.01033	65	0.05673	0.00621	0.00817	93	0.01317	2.25856	132.970	0.02554	0.07807
Glycerate dehydrogenase	0.06896	0.00650	0.08647	0.00693	0.01033	65	0.05673	0.00621	0.00817	93	0.01317	2.25856	132.970	0.02554	0.07807
Ornithine decarboxylase	0.06896	0.00650	0.08647	0.00693	0.01033	65	0.05673	0.00621	0.00817	93	0.01317	2.25856	132.970	0.02554	0.07807
Triphosphoribosyl-dephospho-CoA synthase	0.06896	0.00650	0.08647	0.00693	0.01033	65	0.05673	0.00621	0.00817	93	0.01317	2.25856	132.970	0.02554	0.07807
4-hydroxy-tetrahydrodipicolinate synthase	0.06349	0.00724	0.07440	0.00842	0.01138	65	0.05586	0.00813	0.00935	93	0.01473	1.25830	136.294	0.21043	0.25748
Aspartyl aminopeptidase	0.06176	0.00621	0.07572	0.00633	0.00987	65	0.05199	0.00577	0.00788	93	0.01263	1.87918	133.751	0.06240	0.08686
Phosphoglycerate dehydrogenase	0.06176	0.00621	0.07572	0.00633	0.00987	65	0.05199	0.00577	0.00788	93	0.01263	1.87918	133.751	0.06240	0.08686
Tyrosine phenol-lyase	0.06176	0.00621	0.07572	0.00633	0.00987	65	0.05199	0.00577	0.00788	93	0.01263	1.87918	133.751	0.06240	0.08686
2’,3’-cyclic-nucleotide 3’-phosphodiesterase	0.05926	0.00612	0.07549	0.00629	0.00984	65	0.04791	0.00541	0.00763	93	0.01245	2.21545	131.128	0.02845	0.07807
4-nitrophenylphosphatase	0.05926	0.00612	0.07549	0.00629	0.00984	65	0.04791	0.00541	0.00763	93	0.01245	2.21545	131.128	0.02845	0.07807
Ceramide glucosyltransferase	0.05926	0.00612	0.07549	0.00629	0.00984	65	0.04791	0.00541	0.00763	93	0.01245	2.21545	131.128	0.02845	0.07807
Dipeptidase E	0.05926	0.00612	0.07549	0.00629	0.00984	65	0.04791	0.00541	0.00763	93	0.01245	2.21545	131.128	0.02845	0.07807
Dolichyl-phosphate beta-D-mannosyltransferase	0.05926	0.00612	0.07549	0.00629	0.00984	65	0.04791	0.00541	0.00763	93	0.01245	2.21545	131.128	0.02845	0.07807
Nitrogenase	0.05926	0.00612	0.07549	0.00629	0.00984	65	0.04791	0.00541	0.00763	93	0.01245	2.21545	131.128	0.02845	0.07807
Nitronate monooxygenase	0.05926	0.00612	0.07549	0.00629	0.00984	65	0.04791	0.00541	0.00763	93	0.01245	2.21545	131.128	0.02845	0.07807
Phosphoenolpyruvate carboxykinase (ATP)	0.05926	0.00612	0.07549	0.00629	0.00984	65	0.04791	0.00541	0.00763	93	0.01245	2.21545	131.128	0.02845	0.07807
Phosphonate-transporting ATPase	0.05926	0.00612	0.07549	0.00629	0.00984	65	0.04791	0.00541	0.00763	93	0.01245	2.21545	131.128	0.02845	0.07807
Prolyl aminopeptidase	0.05926	0.00612	0.07549	0.00629	0.00984	65	0.04791	0.00541	0.00763	93	0.01245	2.21545	131.128	0.02845	0.07807
Triacylglycerol lipase	0.05926	0.00612	0.07549	0.00629	0.00984	65	0.04791	0.00541	0.00763	93	0.01245	2.21545	131.128	0.02845	0.07807
Tryptophan synthase	0.05926	0.00612	0.07549	0.00629	0.00984	65	0.04791	0.00541	0.00763	93	0.01245	2.21545	131.128	0.02845	0.07807
(R)-2-methylmalate dehydratase	0.05476	0.00903	0.06849	0.01511	0.01525	65	0.04517	0.01123	0.01099	93	0.01880	1.24093	124.404	0.21697	0.25748
3-isopropylmalate dehydratase	0.05476	0.00903	0.06849	0.01511	0.01525	65	0.04517	0.01123	0.01099	93	0.01880	1.24093	124.404	0.21697	0.25748
Propanediol dehydratase	0.05303	0.01093	0.06982	0.02339	0.01897	65	0.04130	0.01561	0.01296	93	0.02297	1.24131	119.558	0.21692	0.25748
5’ to 3’ exodeoxyribonuclease (nucleoside 3’-phosphate-forming)	0.05128	0.00584	0.06319	0.00587	0.00950	65	0.04296	0.00496	0.00730	93	0.01198	1.68885	130.298	0.09364	0.12603
Type III site-specific deoxyribonuclease	0.04506	0.00780	0.05752	0.01173	0.01343	65	0.03635	0.00804	0.00930	93	0.01634	1.29541	120.750	0.19765	0.24631
L-fuculose-phosphate aldolase	0.04408	0.00562	0.05245	0.00543	0.00914	65	0.03823	0.00466	0.00708	93	0.01156	1.23025	130.992	0.22081	0.26149
(S)-2-hydroxy-acid oxidase	0.04158	0.00547	0.05222	0.00538	0.00910	65	0.03414	0.00419	0.00671	93	0.01131	1.59813	126.533	0.11251	0.14494
1,4-dihydroxy-2-naphthoate polyprenyltransferase	0.04158	0.00547	0.05222	0.00538	0.00910	65	0.03414	0.00419	0.00671	93	0.01131	1.59813	126.533	0.11251	0.14494
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase	0.04158	0.00547	0.05222	0.00538	0.00910	65	0.03414	0.00419	0.00671	93	0.01131	1.59813	126.533	0.11251	0.14494
D-serine ammonia-lyase	0.04158	0.00547	0.05222	0.00538	0.00910	65	0.03414	0.00419	0.00671	93	0.01131	1.59813	126.533	0.11251	0.14494
Demethylmenaquinone methyltransferase	0.04158	0.00547	0.05222	0.00538	0.00910	65	0.03414	0.00419	0.00671	93	0.01131	1.59813	126.533	0.11251	0.14494
Diamine N-acetyltransferase	0.04158	0.00547	0.05222	0.00538	0.00910	65	0.03414	0.00419	0.00671	93	0.01131	1.59813	126.533	0.11251	0.14494
Formylmethanofuran dehydrogenase	0.04158	0.00547	0.05222	0.00538	0.00910	65	0.03414	0.00419	0.00671	93	0.01131	1.59813	126.533	0.11251	0.14494
Gluconate 5-dehydrogenase	0.04158	0.00547	0.05222	0.00538	0.00910	65	0.03414	0.00419	0.00671	93	0.01131	1.59813	126.533	0.11251	0.14494
Hydroxymethylglutaryl-CoA lyase	0.04158	0.00547	0.05222	0.00538	0.00910	65	0.03414	0.00419	0.00671	93	0.01131	1.59813	126.533	0.11251	0.14494
Isocitrate dehydrogenase (NAD(+))	0.04158	0.00547	0.05222	0.00538	0.00910	65	0.03414	0.00419	0.00671	93	0.01131	1.59813	126.533	0.11251	0.14494
L-rhamnonate dehydratase	0.04158	0.00547	0.05222	0.00538	0.00910	65	0.03414	0.00419	0.00671	93	0.01131	1.59813	126.533	0.11251	0.14494
S-methyl-5-thioribose-1-phosphate isomerase	0.04158	0.00547	0.05222	0.00538	0.00910	65	0.03414	0.00419	0.00671	93	0.01131	1.59813	126.533	0.11251	0.14494
S-methyl-5-thioribose kinase	0.04158	0.00547	0.05222	0.00538	0.00910	65	0.03414	0.00419	0.00671	93	0.01131	1.59813	126.533	0.11251	0.14494
Sulfoacetaldehyde dehydrogenase (acylating)	0.04158	0.00547	0.05222	0.00538	0.00910	65	0.03414	0.00419	0.00671	93	0.01131	1.59813	126.533	0.11251	0.14494
D-ornithine 4,5-aminomutase	0.03535	0.00729	0.04654	0.01039	0.01265	65	0.02753	0.00694	0.00864	93	0.01531	1.24131	119.558	0.21692	0.25748
UDP-N-acetylglucosamine kinase	0.03535	0.00729	0.04654	0.01039	0.01265	65	0.02753	0.00694	0.00864	93	0.01531	1.24131	119.558	0.21692	0.25748
NADH:ubiquinone reductase (H(+)-translocating)	0.03411	0.00818	0.03338	0.00918	0.01188	65	0.03462	0.01167	0.01120	93	0.01633	-0.07562	147.347	0.93982	0.93982
4-hydroxy-tetrahydrodipicolinate reductase	0.02988	0.00470	0.03448	0.00377	0.00762	65	0.02667	0.00331	0.00597	93	0.00967	0.80713	132.028	0.42104	0.48950
Aspartate-semialdehyde dehydrogenase	0.02988	0.00470	0.03448	0.00377	0.00762	65	0.02667	0.00331	0.00597	93	0.00967	0.80713	132.028	0.42104	0.48950
Aspartate kinase	0.02988	0.00470	0.03448	0.00377	0.00762	65	0.02667	0.00331	0.00597	93	0.00967	0.80713	132.028	0.42104	0.48950
Branched-chain-amino-acid transaminase	0.02988	0.00470	0.03448	0.00377	0.00762	65	0.02667	0.00331	0.00597	93	0.00967	0.80713	132.028	0.42104	0.48950
Glutamate–ammonia ligase	0.02988	0.00470	0.03448	0.00377	0.00762	65	0.02667	0.00331	0.00597	93	0.00967	0.80713	132.028	0.42104	0.48950
Homoserine dehydrogenase	0.02988	0.00470	0.03448	0.00377	0.00762	65	0.02667	0.00331	0.00597	93	0.00967	0.80713	132.028	0.42104	0.48950
Methylenetetrahydrofolate reductase (NAD(P)H)	0.02988	0.00470	0.03448	0.00377	0.00762	65	0.02667	0.00331	0.00597	93	0.00967	0.80713	132.028	0.42104	0.48950
N-acyl-D-amino-acid deacylase	0.02988	0.00470	0.03448	0.00377	0.00762	65	0.02667	0.00331	0.00597	93	0.00967	0.80713	132.028	0.42104	0.48950
Threonine synthase	0.02988	0.00470	0.03448	0.00377	0.00762	65	0.02667	0.00331	0.00597	93	0.00967	0.80713	132.028	0.42104	0.48950
CoB–CoM heterodisulfide reductase	0.02911	0.00765	0.03292	0.00919	0.01189	65	0.02645	0.00937	0.01004	93	0.01556	0.41587	138.708	0.67815	0.72235
Hydrogen dehydrogenase (NADP(+))	0.02911	0.00765	0.03292	0.00919	0.01189	65	0.02645	0.00937	0.01004	93	0.01556	0.41587	138.708	0.67815	0.72235
Dihydroxy-acid dehydratase	0.02738	0.00451	0.03425	0.00378	0.00762	65	0.02258	0.00281	0.00549	93	0.00940	1.24093	124.404	0.21697	0.25748
DNA-3-methyladenine glycosylase I	0.02738	0.00451	0.03425	0.00378	0.00762	65	0.02258	0.00281	0.00549	93	0.00940	1.24093	124.404	0.21697	0.25748
Ketol-acid reductoisomerase (NADP(+))	0.02738	0.00451	0.03425	0.00378	0.00762	65	0.02258	0.00281	0.00549	93	0.00940	1.24093	124.404	0.21697	0.25748
O-acetylhomoserine aminocarboxypropyltransferase	0.02738	0.00451	0.03425	0.00378	0.00762	65	0.02258	0.00281	0.00549	93	0.00940	1.24093	124.404	0.21697	0.25748
UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	0.02738	0.00451	0.03425	0.00378	0.00762	65	0.02258	0.00281	0.00549	93	0.00940	1.24093	124.404	0.21697	0.25748
Fumarate hydratase	0.02441	0.00592	0.02241	0.00408	0.00792	65	0.02580	0.00661	0.00843	93	0.01157	-0.29322	153.793	0.76975	0.77109
4-hydroxythreonine-4-phosphate dehydrogenase	0.02018	0.00391	0.02350	0.00260	0.00632	65	0.01785	0.00231	0.00498	93	0.00805	0.70243	132.600	0.48364	0.55775
Diaminopropionate ammonia-lyase	0.02018	0.00391	0.02350	0.00260	0.00632	65	0.01785	0.00231	0.00498	93	0.00805	0.70243	132.600	0.48364	0.55775
DNA (cytosine-5-)-methyltransferase	0.02018	0.00391	0.02350	0.00260	0.00632	65	0.01785	0.00231	0.00498	93	0.00805	0.70243	132.600	0.48364	0.55775
Serine O-acetyltransferase	0.02018	0.00391	0.02350	0.00260	0.00632	65	0.01785	0.00231	0.00498	93	0.00805	0.70243	132.600	0.48364	0.55775
Cyclic pyranopterin phosphate synthase	0.01941	0.00510	0.02195	0.00409	0.00793	65	0.01763	0.00416	0.00669	93	0.01037	0.41587	138.708	0.67815	0.72235
2-isopropylmalate synthase	0.01768	0.00364	0.02327	0.00260	0.00632	65	0.01377	0.00173	0.00432	93	0.00766	1.24131	119.558	0.21692	0.25748
3-isopropylmalate dehydrogenase	0.01768	0.00364	0.02327	0.00260	0.00632	65	0.01377	0.00173	0.00432	93	0.00766	1.24131	119.558	0.21692	0.25748
Aspartate racemase	0.01768	0.00364	0.02327	0.00260	0.00632	65	0.01377	0.00173	0.00432	93	0.00766	1.24131	119.558	0.21692	0.25748
Assimilatory sulfite reductase (ferredoxin)	0.01768	0.00364	0.02327	0.00260	0.00632	65	0.01377	0.00173	0.00432	93	0.00766	1.24131	119.558	0.21692	0.25748
Assimilatory sulfite reductase (NADPH)	0.01768	0.00364	0.02327	0.00260	0.00632	65	0.01377	0.00173	0.00432	93	0.00766	1.24131	119.558	0.21692	0.25748
Homoserine O-succinyltransferase	0.01768	0.00364	0.02327	0.00260	0.00632	65	0.01377	0.00173	0.00432	93	0.00766	1.24131	119.558	0.21692	0.25748
NAD(P)H dehydrogenase (quinone)	0.01768	0.00364	0.02327	0.00260	0.00632	65	0.01377	0.00173	0.00432	93	0.00766	1.24131	119.558	0.21692	0.25748
Propanal dehydrogenase (CoA-propanoylating)	0.01768	0.00364	0.02327	0.00260	0.00632	65	0.01377	0.00173	0.00432	93	0.00766	1.24131	119.558	0.21692	0.25748
Protein-serine/threonine phosphatase	0.01768	0.00364	0.02327	0.00260	0.00632	65	0.01377	0.00173	0.00432	93	0.00766	1.24131	119.558	0.21692	0.25748
S-ribosylhomocysteine lyase	0.01768	0.00364	0.02327	0.00260	0.00632	65	0.01377	0.00173	0.00432	93	0.00766	1.24131	119.558	0.21692	0.25748
Type II site-specific deoxyribonuclease	0.01768	0.00364	0.02327	0.00260	0.00632	65	0.01377	0.00173	0.00432	93	0.00766	1.24131	119.558	0.21692	0.25748
UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase	0.01768	0.00364	0.02327	0.00260	0.00632	65	0.01377	0.00173	0.00432	93	0.00766	1.24131	119.558	0.21692	0.25748
(4S)-4-hydroxy-2-oxoglutarate aldolase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
[Ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
2-dehydro-3-deoxy-phosphogluconate aldolase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
2-dehydro-3-deoxygluconokinase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
6-carboxytetrahydropterin synthase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
6-pyruvoyltetrahydropterin synthase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Argininosuccinate lyase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Argininosuccinate synthase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Aspartate ammonia-lyase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Biotin carboxylase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Cytidine deaminase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Deoxyribose-phosphate aldolase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Diacylglycerol kinase (ATP)	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Diaminopimelate epimerase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Glucose-1-phosphate thymidylyltransferase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Glutamate synthase (NADH)	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Glutamate synthase (NADPH)	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Glycerate 3-kinase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Glycine hydroxymethyltransferase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Malate dehydrogenase (oxaloacetate-decarboxylating)	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Mannose-6-phosphate isomerase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Phosphate-transporting ATPase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Prephenate dehydratase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Propionate CoA-transferase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Pyridoxal kinase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Superoxide reductase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Tetrahydrodipicolinate N-acetyltransferase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
tRNA nucleotidyltransferase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Uridine kinase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
Xanthine phosphoribosyltransferase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
XTP/dITP diphosphatase	0.01220	0.00296	0.01121	0.00102	0.00396	65	0.01290	0.00165	0.00421	93	0.00578	-0.29322	153.793	0.76975	0.77109
1-acylglycerol-3-phosphate O-acyltransferase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
2-deoxy-D-gluconate 3-dehydrogenase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
2-phosphosulfolactate phosphatase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
23S rRNA (guanine(745)-N(1))-methyltransferase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
3-hydroxybutyryl-CoA dehydratase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
5-dehydro-4-deoxy-D-glucuronate isomerase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
6-phospho-beta-glucosidase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
7-carboxy-7-deazaguanine synthase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
7-cyano-7-deazaguanine synthase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Adenine deaminase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Altronate dehydratase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Beta-fructofuranosidase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Carbon-monoxide dehydrogenase (acceptor)	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Carbonate dehydratase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
CTP synthase (glutamine hydrolyzing)	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
D-ribose pyranase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Deoxyribonuclease IV	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Diaminopimelate decarboxylase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Dihydropyrimidinase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Ferredoxin–nitrite reductase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Fructokinase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Glutamate-5-semialdehyde dehydrogenase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Glutamate 5-kinase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Glutamate carboxypeptidase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Hippurate hydrolase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
HslU–HslV peptidase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
L-seryl-tRNA(Sec) selenium transferase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Maltose-6’-phosphate glucosidase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Methylaspartate ammonia-lyase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Methylglyoxal synthase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Muramoyltetrapeptide carboxypeptidase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Phosphopentomutase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Pyrroline-5-carboxylate reductase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Ribokinase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Selenide, water dikinase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Succinate dehydrogenase (quinone)	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
UDP-glucose 6-dehydrogenase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
Urocanate reductase	0.00970	0.00255	0.01097	0.00102	0.00396	65	0.00882	0.00104	0.00335	93	0.00519	0.41587	138.708	0.67815	0.72235
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	0.00250	0.00160	0.00023	0.00000	0.00023	65	0.00408	0.00068	0.00271	93	0.00272	-1.41898	93.335	0.15924	0.19974
4-hydroxybutanoyl-CoA dehydratase	0.00250	0.00160	0.00023	0.00000	0.00023	65	0.00408	0.00068	0.00271	93	0.00272	-1.41898	93.335	0.15924	0.19974
Alcohol dehydrogenase	0.00250	0.00160	0.00023	0.00000	0.00023	65	0.00408	0.00068	0.00271	93	0.00272	-1.41898	93.335	0.15924	0.19974
Arogenate dehydratase	0.00250	0.00160	0.00023	0.00000	0.00023	65	0.00408	0.00068	0.00271	93	0.00272	-1.41898	93.335	0.15924	0.19974
Dihydrolipoyl dehydrogenase	0.00250	0.00160	0.00023	0.00000	0.00023	65	0.00408	0.00068	0.00271	93	0.00272	-1.41898	93.335	0.15924	0.19974
Magnesium-importing ATPase	0.00250	0.00160	0.00023	0.00000	0.00023	65	0.00408	0.00068	0.00271	93	0.00272	-1.41898	93.335	0.15924	0.19974
Uridine phosphorylase	0.00250	0.00160	0.00023	0.00000	0.00023	65	0.00408	0.00068	0.00271	93	0.00272	-1.41898	93.335	0.15924	0.19974
Vinylacetyl-CoA Delta-isomerase	0.00250	0.00160	0.00023	0.00000	0.00023	65	0.00408	0.00068	0.00271	93	0.00272	-1.41898	93.335	0.15924	0.19974

plot.dat <- tb.ra %>%
  arrange(desc(`Overall Mean`)) %>%
  slice_head(n=50)%>%
  mutate(
    description = fct_reorder(description, `Overall Mean`),
    description = factor(description, levels = levels(description), ordered=T)
  ) %>%
  arrange(description) %>%
  mutate(
    id = 1:n(),
    step = ifelse(id%%2 == 0, 1, 0),
    Mean_diff = `Tumor Mean` - `Non-Tumor Mean`,
    Mean_diff_ll = Mean_diff - qt(0.975, df)*SEpooled,
    Mean_diff_ul = Mean_diff + qt(0.975, df)*SEpooled
  ) %>%
  pivot_longer(
    cols=contains("Mean"),
    names_to = "group",
    values_to = "mean"
  )



p1.d <- plot.dat %>%
  filter(group %in% c("Tumor Mean","Non-Tumor Mean")) %>%
  mutate(
    group = ifelse(group == "Tumor Mean", "Tumor", "Non-Tumor"),
    col = ifelse(step == 1, "grey90", "white"),
    h=1, w=Inf
    
  )
p1 <- ggplot()+
  geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_bar(data=p1.d,
             aes(x=mean, y=description,
                 group=group, color=group,
                 fill=group),
             stat="identity",position = "dodge",
             alpha = 1)+
    labs(x="Mean RelAbundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      plot.margin = unit(c(1,0,1,1), "lines")
    )

p2.d <- plot.dat %>%
  filter(group %in% c("Mean_diff", "Mean_diff_ll", "Mean_diff_ul")) %>%
  pivot_wider(
    names_from = group,
    values_from = mean
  ) %>%
  mutate(
    group = ifelse(Mean_diff > 0, "Tumor", "Non-Tumor"),
    p = sprintf("%.3f", round(fdr_p,3)),
    ll = min(Mean_diff_ll)-0.01,
    ul = max(Mean_diff_ul)+0.01
  )
p2<-ggplot(p2.d, aes(x=Mean_diff, y=description))+
    geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_vline(xintercept = 0, linetype="dashed", alpha=0.5)+
    geom_segment(aes(x=Mean_diff_ll, y=description, xend=Mean_diff_ul, yend=description))+
    geom_point(aes(fill=group, color=group))+
    geom_text(aes(label=p, x=unique(ul)+0.05))+
    coord_cartesian(xlim = c(unique(p2.d$ll), unique(p2.d$ul)),
                    clip = 'off') +
    annotate("text", x=unique(p2.d$ul)+0.10,y = 25,
             angle=90,
             label="q-value (FDR Corrected p-value)")+
    labs(x="Mean Difference in RelAbundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      axis.title.y = element_blank(),
      axis.text.y = element_blank(),
      axis.line.y = element_blank(),
      axis.ticks.y = element_blank(),
      plot.margin = unit(c(1,4,1,0), "lines")
    )

# plot
p <-p1 + p2 +
  plot_annotation(title="Stratefied EC Data - Fusobacterium nucleatum: 50 most abundant descriptions")
p

ggsave("output/updated-figures-2021-05-20/picrust-fuso-EC.pdf",p,units="in", height=12, width=10)

Modeling Difference between Tumor and Non-Tumor

For the modeling, we used a generalized linear mixed model (GLMM).

First, we looked at the biserial correlation between the abundance of each description and the tumor status.

tb <- mydata %>%
  group_by(description)%>%
  summarise(
    r = cor(tumor, RelAbundance)
  ) %>%
  mutate(
    M=mean(r)
  )

ggplot(tb, aes(x=r))+
  geom_density()+
  geom_vline(aes(xintercept = M))+
  labs(x="Biserial Correlation",title="Relationship between description abundance and tumor (tumor vs. non-tumor)")+
  theme(panel.grid = element_blank())

Next, we need the data to be on an interpretable scale. First, let’s use the raw abundance like scale.

p <- ggplot(mydata, aes(x=Abundance))+
  geom_density()
p

mydata <- mydata %>%
  mutate(Abundance.dich=ifelse(Abundance==0, 0, 1))
table(mydata$Abundance.dich)

    0     1 
56739 33637 

Let’s first run models by description so that we can avoid the nesting issue initially. We will come back to this to conduct the final model (it will be more powerful).

DESCRIPTIONS <- unique(mydata$description)
i<-1
dat0 <- mydata %>% filter(description==DESCRIPTIONS[i])

# quasipossion (approximately negative binom) give an approx. answer.
fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
summary(fit0)

Call:
glm(formula = Abundance ~ 1 + tumor, family = quasipoisson(link = "log"), 
    data = dat0)

Deviance Residuals: 
   Min      1Q  Median      3Q     Max  
 -6.85   -5.67   -3.93   -3.05   37.70  

Coefficients:
            Estimate Std. Error t value Pr(>|t|)    
(Intercept)    2.042      0.457    4.47 0.000015 ***
tumor          1.115      0.553    2.02    0.046 *  
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for quasipoisson family taken to be 149.33)

    Null deviance: 9844.2  on 157  degrees of freedom
Residual deviance: 9182.4  on 156  degrees of freedom
AIC: NA

Number of Fisher Scoring iterations: 7

Run over all descriptors

results.out <- as.data.frame(matrix(ncol=4, nrow=length(DESCRIPTIONS)))
colnames(results.out) <- c("description", "Est", "SE", "p")
#results.out$description <-DESCRIPTIONS

i <- 1
for(i in 1:length(DESCRIPTIONS)){
#for(i in 1:5){ 
  dat0 <- mydata %>%
    filter(description == DESCRIPTIONS[i])
  fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
  fit.sum <- summary(fit0)
  results.out[i, 1] <- DESCRIPTIONS[i]
  results.out[i, 2:4] <- fit.sum$coefficients[2, c(1,2,4)]
}

results.out$fdr_p <- p.adjust(results.out$p, method="fdr")

kable(results.out, format="html", digits=3) %>%
  kable_styling(full_width = T)%>%
  scroll_box(width="100%", height="600px")

description	Est	SE	p	fdr_p
(2E,6E)-farnesyl diphosphate synthase	1.115	0.553	0.046	0.059
(4S)-4-hydroxy-2-oxoglutarate aldolase	-0.298	0.779	0.702	0.720
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ferredoxin)	1.115	0.553	0.046	0.059
(E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (flavodoxin)	1.115	0.553	0.046	0.059
(FADH(2)-oxidizing)	1.115	0.553	0.046	0.059
(R)-2-methylmalate dehydratase	0.802	0.500	0.111	0.133
(S)-2-hydroxy-acid oxidase	1.359	0.653	0.039	0.059
[Acyl-carrier-protein] S-malonyltransferase	1.115	0.553	0.046	0.059
[Citrate (pro-3S)-lyase] ligase	1.289	0.586	0.029	0.059
[Formate-C-acetyltransferase]-activating enzyme	1.115	0.553	0.046	0.059
[Ribosomal protein S12] (aspartate(89)-C(3))-methylthiotransferase	-0.298	0.779	0.702	0.720
1-acylglycerol-3-phosphate O-acyltransferase	0.551	0.679	0.419	0.457
1-deoxy-D-xylulose-5-phosphate reductoisomerase	1.115	0.553	0.046	0.059
1-deoxy-D-xylulose-5-phosphate synthase	1.136	0.569	0.048	0.061
1-phosphofructokinase	1.115	0.553	0.046	0.059
1,4-alpha-glucan branching enzyme	1.115	0.553	0.046	0.059
1,4-dihydroxy-2-naphthoate polyprenyltransferase	1.359	0.653	0.039	0.059
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase	1.115	0.553	0.046	0.059
16S rRNA (cytidine(1402)-2’-O)-methyltransferase	1.115	0.553	0.046	0.059
16S rRNA (cytidine(1409)-2’-O)-methyltransferase	1.115	0.553	0.046	0.059
16S rRNA (cytosine(1402)-N(4))-methyltransferase	1.115	0.553	0.046	0.059
16S rRNA (cytosine(967)-C(5))-methyltransferase	1.115	0.553	0.046	0.059
16S rRNA (guanine(1207)-N(2))-methyltransferase	1.115	0.553	0.046	0.059
16S rRNA (guanine(527)-N(7))-methyltransferase	1.115	0.553	0.046	0.059
16S rRNA (uracil(1498)-N(3))-methyltransferase	1.115	0.553	0.046	0.059
16S rRNA pseudouridine(516) synthase	1.115	0.553	0.046	0.059
2’,3’-cyclic-nucleotide 3’-phosphodiesterase	1.352	0.629	0.033	0.059
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase	1.115	0.553	0.046	0.059
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	1.115	0.553	0.046	0.059
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	1.115	0.553	0.046	0.059
2-dehydro-3-deoxy-phosphogluconate aldolase	-0.298	0.779	0.702	0.720
2-dehydro-3-deoxygluconokinase	-0.298	0.779	0.702	0.720
2-deoxy-D-gluconate 3-dehydrogenase	0.551	0.679	0.419	0.457
2-iminoacetate synthase	0.945	0.526	0.074	0.091
2-iminobutanoate/2-iminopropanoate deaminase	1.115	0.553	0.046	0.059
2-isopropylmalate synthase	1.219	0.577	0.036	0.059
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase	1.359	0.653	0.039	0.059
2-phosphosulfolactate phosphatase	0.551	0.679	0.419	0.457
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase	-1.604	1.840	0.385	0.455
2.7.11.30 and 2.7.12.1	1.289	0.586	0.029	0.059
23S rRNA (adenine(2503)-C(2))-methyltransferase	1.115	0.553	0.046	0.059
23S rRNA (cytidine(1920)-2’-O)-methyltransferase	1.115	0.553	0.046	0.059
23S rRNA (cytosine(1962)-C(5))-methyltransferase	1.115	0.553	0.046	0.059
23S rRNA (guanine(745)-N(1))-methyltransferase	0.551	0.679	0.419	0.457
23S rRNA (guanosine(2251)-2’-O)-methyltransferase	1.115	0.553	0.046	0.059
23S rRNA (pseudouridine(1915)-N(3))-methyltransferase	1.115	0.553	0.046	0.059
23S rRNA (uracil(1939)-C(5))-methyltransferase	1.115	0.553	0.046	0.059
23S rRNA pseudouridine(1911/1915/1917) synthase	1.115	0.553	0.046	0.059
23S rRNA pseudouridine(2605) synthase	1.115	0.553	0.046	0.059
23S rRNA pseudouridine(955/2504/2580) synthase	1.115	0.553	0.046	0.059
3’(2’),5’-bisphosphate nucleotidase	1.115	0.553	0.046	0.059
3-aminobutyryl-CoA ammonia-lyase	1.115	0.553	0.046	0.059
3-dehydroquinate dehydratase	1.115	0.553	0.046	0.059
3-deoxy-7-phosphoheptulonate synthase	1.115	0.553	0.046	0.059
3-deoxy-8-phosphooctulonate synthase	1.115	0.553	0.046	0.059
3-deoxy-manno-octulosonate-8-phosphatase	1.115	0.553	0.046	0.059
3-deoxy-manno-octulosonate cytidylyltransferase	1.115	0.553	0.046	0.059
3-hydroxyacyl-[acyl-carrier-protein] dehydratase	1.115	0.553	0.046	0.059
3-hydroxybutyryl-CoA dehydratase	0.551	0.679	0.419	0.457
3-hydroxybutyryl-CoA dehydrogenase	1.115	0.553	0.046	0.059
3-isopropylmalate dehydratase	0.802	0.500	0.111	0.133
3-isopropylmalate dehydrogenase	1.219	0.577	0.036	0.059
3-oxoacyl-[acyl-carrier-protein] reductase	1.115	0.553	0.046	0.059
3-phosphoshikimate 1-carboxyvinyltransferase	1.115	0.553	0.046	0.059
3,4-dihydroxy-2-butanone-4-phosphate synthase	1.115	0.553	0.046	0.059
4-(cytidine 5’-diphospho)-2-C-methyl-D-erythritol kinase	1.115	0.553	0.046	0.059
4-alpha-glucanotransferase	1.115	0.553	0.046	0.059
4-hydroxy-3-methylbut-2-enyl diphosphate reductase	1.115	0.553	0.046	0.059
4-hydroxy-tetrahydrodipicolinate reductase	0.087	0.625	0.890	0.890
4-hydroxy-tetrahydrodipicolinate synthase	1.072	0.542	0.050	0.063
4-hydroxybutanoyl-CoA dehydratase	-1.604	1.840	0.385	0.455
4-hydroxythreonine-4-phosphate dehydrogenase	-0.215	0.897	0.811	0.825
4-nitrophenylphosphatase	1.352	0.629	0.033	0.059
5’ to 3’ exodeoxyribonuclease (nucleoside 3’-phosphate-forming)	1.292	0.606	0.034	0.059
5-(carboxyamino)imidazole ribonucleotide mutase	1.115	0.553	0.046	0.059
5-amino-6-(5-phosphoribosylamino)uracil reductase	1.115	0.553	0.046	0.059
5-dehydro-4-deoxy-D-glucuronate isomerase	0.551	0.679	0.419	0.457
5-formyltetrahydrofolate cyclo-ligase	1.115	0.553	0.046	0.059
6-carboxytetrahydropterin synthase	-0.298	0.779	0.702	0.720
6-phospho-beta-glucosidase	0.551	0.679	0.419	0.457
6-phosphofructokinase	1.115	0.553	0.046	0.059
6-pyruvoyltetrahydropterin synthase	-0.298	0.779	0.702	0.720
6,7-dimethyl-8-ribityllumazine synthase	1.115	0.553	0.046	0.059
7-carboxy-7-deazaguanine synthase	0.551	0.679	0.419	0.457
7-cyano-7-deazaguanine synthase	0.551	0.679	0.419	0.457
8-amino-7-oxononanoate synthase	1.115	0.553	0.046	0.059
8-oxo-dGTP diphosphatase	1.223	0.582	0.037	0.059
Acetate CoA-transferase	1.223	0.591	0.040	0.059
Acetate kinase	1.115	0.553	0.046	0.059
Acetolactate synthase	1.235	0.541	0.024	0.059
Acetyl-CoA C-acetyltransferase	1.115	0.553	0.046	0.059
Acetyl-CoA carboxylase	1.024	0.536	0.058	0.072
acetylglucosaminyltransferase	1.115	0.553	0.046	0.059
Acyl-[acyl-carrier-protein]–UDP-N-acetylglucosamine O-acyltransferase	1.115	0.553	0.046	0.059
Acylaminoacyl-peptidase	1.115	0.553	0.046	0.059
Adenine deaminase	0.551	0.679	0.419	0.457
Adenine phosphoribosyltransferase	1.223	0.582	0.037	0.059
Adenosylcobalamin/alpha-ribazole phosphatase	1.115	0.553	0.046	0.059
Adenosylcobinamide-GDP ribazoletransferase	1.115	0.553	0.046	0.059
Adenosylcobinamide-phosphate guanylyltransferase	1.115	0.553	0.046	0.059
Adenosylcobinamide-phosphate synthase	1.115	0.553	0.046	0.059
Adenosylcobinamide kinase	1.115	0.553	0.046	0.059
Adenosylcobyric acid synthase (glutamine-hydrolyzing)	1.115	0.553	0.046	0.059
Adenosylhomocysteine nucleosidase	1.115	0.553	0.046	0.059
Adenosylmethionine–8-amino-7-oxononanoate transaminase	1.115	0.553	0.046	0.059
Adenylate kinase	1.115	0.553	0.046	0.059
Adenylosuccinate lyase	1.115	0.553	0.046	0.059
Adenylosuccinate synthase	1.115	0.553	0.046	0.059
ADP-glyceromanno-heptose 6-epimerase	1.115	0.553	0.046	0.059
ADP-ribose diphosphatase	1.115	0.553	0.046	0.059
Alanine–tRNA ligase	1.115	0.553	0.046	0.059
Alanine racemase	1.115	0.553	0.046	0.059
Alcohol dehydrogenase	-1.604	1.840	0.385	0.455
Aldose 1-epimerase	1.115	0.553	0.046	0.059
Altronate dehydratase	0.551	0.679	0.419	0.457
Amidophosphoribosyltransferase	1.115	0.553	0.046	0.059
Aminoacyl-tRNA hydrolase	1.115	0.553	0.046	0.059
Aminodeoxychorismate lyase	1.289	0.586	0.029	0.059
Aminodeoxychorismate synthase	1.319	0.606	0.031	0.059
Arabinose-5-phosphate isomerase	1.115	0.553	0.046	0.059
Arginine–tRNA ligase	1.115	0.553	0.046	0.059
Argininosuccinate lyase	-0.298	0.779	0.702	0.720
Argininosuccinate synthase	-0.298	0.779	0.702	0.720
Arogenate dehydratase	-1.604	1.840	0.385	0.455
Aromatic-amino-acid transaminase	1.115	0.553	0.046	0.059
Arsenate reductase (glutaredoxin)	1.119	0.539	0.040	0.059
Arsenite-transporting ATPase	1.359	0.653	0.039	0.059
Asparaginase	1.115	0.553	0.046	0.059
Asparagine–tRNA ligase	1.115	0.553	0.046	0.059
Asparaginyl-tRNA synthase (glutamine-hydrolyzing)	1.115	0.553	0.046	0.059
Aspartate–ammonia ligase	1.115	0.553	0.046	0.059
Aspartate–tRNA ligase	1.115	0.553	0.046	0.059
Aspartate-semialdehyde dehydrogenase	0.087	0.625	0.890	0.890
Aspartate ammonia-lyase	-0.298	0.779	0.702	0.720
Aspartate carbamoyltransferase	1.115	0.553	0.046	0.059
Aspartate kinase	0.087	0.625	0.890	0.890
Aspartate racemase	1.219	0.577	0.036	0.059
Aspartate transaminase	1.115	0.553	0.046	0.059
Aspartyl aminopeptidase	1.158	0.588	0.051	0.064
Assimilatory sulfite reductase (ferredoxin)	1.219	0.577	0.036	0.059
Assimilatory sulfite reductase (NADPH)	1.219	0.577	0.036	0.059
Beta-fructofuranosidase	0.551	0.679	0.419	0.457
Beta-ketoacyl-[acyl-carrier-protein] synthase II	1.115	0.553	0.046	0.059
Beta-ketoacyl-[acyl-carrier-protein] synthase III	1.223	0.582	0.037	0.059
Beta-lactamase	1.289	0.586	0.029	0.059
Beta-lysine 5,6-aminomutase	1.115	0.553	0.046	0.059
Biotin–[acetyl-CoA-carboxylase] ligase	1.115	0.553	0.046	0.059
Biotin carboxylase	-0.298	0.779	0.702	0.720
Biotin synthase	0.945	0.526	0.074	0.091
Branched-chain-amino-acid transaminase	0.087	0.625	0.890	0.890
Butyrate–acetoacetate CoA-transferase	1.223	0.591	0.040	0.059
C-terminal processing peptidase	1.115	0.553	0.046	0.059
Cadmium-exporting ATPase	1.115	0.553	0.046	0.059
Caffeoyl-CoA O-methyltransferase	1.115	0.553	0.046	0.059
Calcium-transporting ATPase	1.115	0.553	0.046	0.059
Carbamoyl-phosphate synthase (glutamine-hydrolyzing)	1.115	0.553	0.046	0.059
Carbon-monoxide dehydrogenase (acceptor)	0.551	0.679	0.419	0.457
Carbonate dehydratase	0.551	0.679	0.419	0.457
Carboxypeptidase Taq	1.115	0.553	0.046	0.059
CCA tRNA nucleotidyltransferase	1.115	0.553	0.046	0.059
CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyltransferase	1.136	0.569	0.048	0.061
CDP-diacylglycerol–serine O-phosphatidyltransferase	1.115	0.553	0.046	0.059
Ceramide glucosyltransferase	1.352	0.629	0.033	0.059
Chorismate mutase	0.922	0.508	0.071	0.088
Chorismate synthase	1.115	0.553	0.046	0.059
Citrate CoA-transferase	1.115	0.553	0.046	0.059
Citrate lyase holo-[acyl-carrier protein] synthase	1.289	0.586	0.029	0.059
Citryl-CoA lyase	1.115	0.553	0.046	0.059
CoB–CoM heterodisulfide reductase	0.551	0.679	0.419	0.457
Cob(I)yrinic acid a,c-diamide adenosyltransferase	1.244	0.577	0.032	0.059
Cobalt-factor II C(20)-methyltransferase	1.115	0.553	0.046	0.059
Cobalt-precorrin-4 methyltransferase	1.115	0.553	0.046	0.059
Cobalt-precorrin-5B (C(1))-methyltransferase	1.115	0.553	0.046	0.059
Cobalt-precorrin-6A reductase	1.115	0.553	0.046	0.059
Cobalt-precorrin-6B (C(15))-methyltransferase (decarboxylating)	1.115	0.553	0.046	0.059
Cobalt-precorrin-7 (C(5))-methyltransferase	1.115	0.553	0.046	0.059
Cobalt-precorrin-8 methylmutase	1.115	0.553	0.046	0.059
Cobalt-precorrin 5A hydrolase	1.115	0.553	0.046	0.059
Cobyrinate a,c-diamide synthase (glutamine-hydrolyzing)	1.115	0.553	0.046	0.059
Coproporphyrinogen dehydrogenase	1.053	0.541	0.053	0.067
Crossover junction endodeoxyribonuclease	1.119	0.539	0.040	0.059
CTP synthase (glutamine hydrolyzing)	0.551	0.679	0.419	0.457
Cu(+) exporting ATPase	1.115	0.553	0.046	0.059
Cyclic pyranopterin phosphate synthase	0.551	0.679	0.419	0.457
Cystathionine beta-lyase	1.129	0.564	0.047	0.060
Cystathionine gamma-synthase	1.355	0.641	0.036	0.059
Cysteine–tRNA ligase	1.263	0.595	0.035	0.059
Cysteine desulfurase	1.119	0.539	0.040	0.059
Cysteine synthase	1.317	0.596	0.029	0.059
Cytidine deaminase	-0.298	0.779	0.702	0.720
D-alanine–D-alanine ligase	1.115	0.553	0.046	0.059
D-glycero-alpha-D-manno-heptose-1,7-bisphosphate 7-phosphatase	-0.298	0.779	0.702	0.720
D-glycero-beta-D-manno-heptose 1,7-bisphosphate 7-phosphatase	-0.298	0.779	0.702	0.720
D-lactate dehydrogenase	1.115	0.553	0.046	0.059
D-ornithine 4,5-aminomutase	1.219	0.577	0.036	0.059
D-ribose pyranase	0.551	0.679	0.419	0.457
D-sedoheptulose 7-phosphate isomerase	1.115	0.553	0.046	0.059
D-serine ammonia-lyase	1.359	0.653	0.039	0.059
dCMP deaminase	1.115	0.553	0.046	0.059
Demethylmenaquinone methyltransferase	1.359	0.653	0.039	0.059
Deoxyribonuclease IV	0.551	0.679	0.419	0.457
Deoxyribose-phosphate aldolase	-0.298	0.779	0.702	0.720
Dephospho-CoA kinase	1.115	0.553	0.046	0.059
Dethiobiotin synthase	1.115	0.553	0.046	0.059
Diacylglycerol kinase (ATP)	-0.298	0.779	0.702	0.720
Diadenylate cyclase	1.115	0.553	0.046	0.059
Diamine N-acetyltransferase	1.359	0.653	0.039	0.059
Diaminohydroxyphosphoribosylaminopyrimidine deaminase	1.115	0.553	0.046	0.059
Diaminopimelate decarboxylase	0.551	0.679	0.419	0.457
Diaminopimelate epimerase	-0.298	0.779	0.702	0.720
Diaminopropionate ammonia-lyase	-0.215	0.897	0.811	0.825
Dihydrofolate reductase	1.115	0.553	0.046	0.059
Dihydrofolate synthase	1.115	0.553	0.046	0.059
Dihydrolipoyl dehydrogenase	-1.604	1.840	0.385	0.455
Dihydroneopterin aldolase	1.115	0.553	0.046	0.059
Dihydroorotase	1.115	0.553	0.046	0.059
Dihydroorotate dehydrogenase (NAD(+))	1.115	0.553	0.046	0.059
Dihydropteroate synthase	1.115	0.553	0.046	0.059
Dihydropyrimidinase	0.551	0.679	0.419	0.457
Dihydroxy-acid dehydratase	0.802	0.500	0.111	0.133
Dimethylallyltranstransferase	1.115	0.553	0.046	0.059
Dipeptidase E	1.352	0.629	0.033	0.059
diphosphate specific)	1.115	0.553	0.046	0.059
DNA-(apurinic or apyrimidinic site) lyase	1.119	0.539	0.040	0.059
DNA-3-methyladenine glycosylase I	0.802	0.500	0.111	0.133
DNA-directed DNA polymerase	1.094	0.547	0.047	0.060
DNA-directed RNA polymerase	1.115	0.553	0.046	0.059
DNA (cytosine-5-)-methyltransferase	-0.215	0.897	0.811	0.825
DNA helicase	1.115	0.553	0.046	0.059
DNA ligase (NAD(+))	1.115	0.553	0.046	0.059
DNA topoisomerase	1.119	0.539	0.040	0.059
DNA topoisomerase (ATP-hydrolyzing)	1.115	0.553	0.046	0.059
Dolichyl-phosphate beta-D-mannosyltransferase	1.352	0.629	0.033	0.059
dTDP-4-dehydrorhamnose 3,5-epimerase	1.223	0.582	0.037	0.059
dTDP-4-dehydrorhamnose reductase	1.078	0.528	0.043	0.059
dTDP-glucose 4,6-dehydratase	1.115	0.553	0.046	0.059
dTMP kinase	1.115	0.553	0.046	0.059
dUTP diphosphatase	1.115	0.553	0.046	0.059
Endopeptidase Clp	1.115	0.553	0.046	0.059
Endopeptidase La	1.223	0.591	0.040	0.059
Enoyl-[acyl-carrier-protein] reductase (NADH)	1.115	0.553	0.046	0.059
Enoyl-CoA hydratase	1.115	0.553	0.046	0.059
Ethanolamine ammonia-lyase	1.352	0.629	0.033	0.059
Exodeoxyribonuclease III	1.115	0.553	0.046	0.059
Exodeoxyribonuclease VII	1.185	0.571	0.040	0.059
Exopolyphosphatase	1.115	0.553	0.046	0.059
FAD synthetase	1.115	0.553	0.046	0.059
Fe(3+)-transporting ATPase	1.198	0.565	0.035	0.059
Ferredoxin–nitrite reductase	0.551	0.679	0.419	0.457
Formate–tetrahydrofolate ligase	1.115	0.553	0.046	0.059
Formate C-acetyltransferase	1.115	0.553	0.046	0.059
Formimidoylglutamase	1.115	0.553	0.046	0.059
Formimidoyltetrahydrofolate cyclodeaminase	1.355	0.641	0.036	0.059
Formylmethanofuran dehydrogenase	1.359	0.653	0.039	0.059
Fructokinase	0.551	0.679	0.419	0.457
Fructose-bisphosphatase	1.115	0.553	0.046	0.059
Fructose-bisphosphate aldolase	1.078	0.528	0.043	0.059
Fumarate hydratase	-0.298	0.779	0.702	0.720
Fumarate reductase (quinol)	1.235	0.555	0.027	0.059
Galactokinase	1.115	0.553	0.046	0.059
Gamma-glutamyltransferase	1.359	0.653	0.039	0.059
Geranylgeranyl diphosphate synthase	1.115	0.553	0.046	0.059
Glucokinase	1.078	0.528	0.043	0.059
Gluconate 5-dehydrogenase	1.359	0.653	0.039	0.059
Glucosamine-1-phosphate N-acetyltransferase	1.115	0.553	0.046	0.059
Glucosamine-6-phosphate deaminase	1.115	0.553	0.046	0.059
Glucose-1-phosphate adenylyltransferase	1.115	0.553	0.046	0.059
Glucose-1-phosphate thymidylyltransferase	-0.298	0.779	0.702	0.720
Glucose-6-phosphate isomerase	1.115	0.553	0.046	0.059
Glutaconate CoA-transferase	1.115	0.553	0.046	0.059
Glutaconyl-CoA decarboxylase	1.115	0.553	0.046	0.059
Glutamate–ammonia ligase	0.087	0.625	0.890	0.890
Glutamate–tRNA ligase	1.115	0.553	0.046	0.059
Glutamate-1-semialdehyde 2,1-aminomutase	1.115	0.553	0.046	0.059
Glutamate-5-semialdehyde dehydrogenase	0.551	0.679	0.419	0.457
Glutamate 5-kinase	0.551	0.679	0.419	0.457
Glutamate carboxypeptidase	0.551	0.679	0.419	0.457
Glutamate dehydrogenase	1.115	0.553	0.046	0.059
Glutamate formimidoyltransferase	1.355	0.641	0.036	0.059
Glutamate racemase	1.083	0.516	0.037	0.059
Glutamate synthase (NADH)	-0.298	0.779	0.702	0.720
Glutamate synthase (NADPH)	-0.298	0.779	0.702	0.720
Glutaminase	1.115	0.553	0.046	0.059
Glutamine–fructose-6-phosphate transaminase (isomerizing)	1.115	0.553	0.046	0.059
Glutaminyl-tRNA synthase (glutamine-hydrolyzing)	1.115	0.553	0.046	0.059
Glutamyl-tRNA reductase	1.115	0.553	0.046	0.059
Glutathione hydrolase	1.359	0.653	0.039	0.059
Glutathione peroxidase	1.115	0.553	0.046	0.059
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)	1.115	0.553	0.046	0.059
Glycerate 3-kinase	-0.298	0.779	0.702	0.720
Glycerate dehydrogenase	1.289	0.586	0.029	0.059
Glycerol-3-phosphate 1-O-acyltransferase	1.115	0.553	0.046	0.059
Glycerol-3-phosphate cytidylyltransferase	1.115	0.553	0.046	0.059
Glycerol-3-phosphate dehydrogenase	1.115	0.553	0.046	0.059
Glycerol-3-phosphate dehydrogenase (NAD(P)(+))	1.115	0.553	0.046	0.059
Glycerol kinase	1.115	0.553	0.046	0.059
Glycerophosphodiester phosphodiesterase	1.223	0.582	0.037	0.059
Glycine–tRNA ligase	1.115	0.553	0.046	0.059
Glycine hydroxymethyltransferase	-0.298	0.779	0.702	0.720
Glycogen phosphorylase	1.115	0.553	0.046	0.059
GMP synthase (glutamine-hydrolyzing)	1.115	0.553	0.046	0.059
GTP cyclohydrolase I	1.115	0.553	0.046	0.059
GTP cyclohydrolase II	1.115	0.553	0.046	0.059
GTP diphosphokinase	1.115	0.553	0.046	0.059
Guanosine-3’,5’-bis(diphosphate) 3’-diphosphatase	1.115	0.553	0.046	0.059
Guanosine-5’-triphosphate,3’-diphosphate diphosphatase	1.115	0.553	0.046	0.059
Guanylate kinase	1.115	0.553	0.046	0.059
H(+)-transporting two-sector ATPase	1.129	0.564	0.047	0.060
Heptaprenyl diphosphate synthase	1.223	0.591	0.040	0.059
Hippurate hydrolase	0.551	0.679	0.419	0.457
Histidine–tRNA ligase	1.115	0.553	0.046	0.059
Histidine ammonia-lyase	1.223	0.591	0.040	0.059
Histidine kinase	0.938	0.511	0.068	0.084
Histidinol-phosphatase	1.115	0.553	0.046	0.059
Holo-[acyl-carrier-protein] synthase	1.115	0.553	0.046	0.059
Homoserine dehydrogenase	0.087	0.625	0.890	0.890
Homoserine kinase	1.119	0.539	0.040	0.059
Homoserine O-succinyltransferase	1.219	0.577	0.036	0.059
HslU–HslV peptidase	0.551	0.679	0.419	0.457
Hydrogen dehydrogenase (NADP(+))	0.551	0.679	0.419	0.457
Hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolyzing)	1.115	0.553	0.046	0.059
Hydroxyacylglutathione hydrolase	1.115	0.553	0.046	0.059
Hydroxylamine reductase	1.115	0.553	0.046	0.059
Hydroxymethylbilane synthase	1.115	0.553	0.046	0.059
Hydroxymethylglutaryl-CoA lyase	1.359	0.653	0.039	0.059
Hydroxymethylpyrimidine kinase	1.115	0.553	0.046	0.059
Hypoxanthine phosphoribosyltransferase	1.115	0.553	0.046	0.059
Imidazolonepropionase	1.223	0.591	0.040	0.059
IMP cyclohydrolase	1.115	0.553	0.046	0.059
IMP dehydrogenase	1.115	0.553	0.046	0.059
Inorganic diphosphatase	1.184	0.577	0.042	0.059
Iron-chelate-transporting ATPase	1.206	0.582	0.040	0.059
Isocitrate dehydrogenase (NAD(+))	1.359	0.653	0.039	0.059
Isoleucine–tRNA ligase	1.115	0.553	0.046	0.059
Kdo(2)-lipid IV(A) lauroyltransferase	1.119	0.539	0.040	0.059
Ketol-acid reductoisomerase (NADP(+))	0.802	0.500	0.111	0.133
L-aspartate oxidase	1.115	0.553	0.046	0.059
L-erythro-3,5-diaminohexanoate dehydrogenase	1.115	0.553	0.046	0.059
L-fuculose-phosphate aldolase	1.155	0.607	0.059	0.073
L-lactate dehydrogenase	1.115	0.553	0.046	0.059
L-rhamnonate dehydratase	1.359	0.653	0.039	0.059
L-serine ammonia-lyase	1.115	0.553	0.046	0.059
L-seryl-tRNA(Sec) selenium transferase	0.551	0.679	0.419	0.457
L-threonine aldolase	1.115	0.553	0.046	0.059
L-threonylcarbamoyladenylate synthase	1.115	0.553	0.046	0.059
Lactaldehyde reductase	1.322	0.616	0.034	0.059
Lactoylglutathione lyase	1.223	0.582	0.037	0.059
Leucine–tRNA ligase	1.115	0.553	0.046	0.059
Leucyl aminopeptidase	1.115	0.553	0.046	0.059
Lipid-A-disaccharide synthase	1.115	0.553	0.046	0.059
Long-chain-fatty-acid–CoA ligase	1.184	0.577	0.042	0.059
Lysine–tRNA ligase	1.115	0.553	0.046	0.059
Lysine 2,3-aminomutase	1.115	0.553	0.046	0.059
Magnesium-importing ATPase	-1.604	1.840	0.385	0.455
Malate dehydrogenase (oxaloacetate-decarboxylating)	-0.298	0.779	0.702	0.720
Malonyl-[acyl-carrier protein] O-methyltransferase	1.115	0.553	0.046	0.059
Maltose-6’-phosphate glucosidase	0.551	0.679	0.419	0.457
Mannose-6-phosphate isomerase	-0.298	0.779	0.702	0.720
Methenyltetrahydrofolate cyclohydrolase	1.115	0.553	0.046	0.059
Methionine–tRNA ligase	1.115	0.553	0.046	0.059
Methionine adenosyltransferase	1.115	0.553	0.046	0.059
Methionine gamma-lyase	1.115	0.553	0.046	0.059
Methionine synthase	1.115	0.553	0.046	0.059
Methionyl-tRNA formyltransferase	1.115	0.553	0.046	0.059
Methionyl aminopeptidase	1.115	0.553	0.046	0.059
Methylaspartate ammonia-lyase	0.551	0.679	0.419	0.457
Methylaspartate mutase	1.198	0.565	0.035	0.059
Methylated-DNA–[protein]-cysteine S-methyltransferase	1.115	0.553	0.046	0.059
Methylenetetrahydrofolate dehydrogenase (NADP(+))	1.115	0.553	0.046	0.059
Methylenetetrahydrofolate reductase (NAD(P)H)	0.087	0.625	0.890	0.890
Methylglyoxal synthase	0.551	0.679	0.419	0.457
Monosaccharide-transporting ATPase	1.096	0.540	0.044	0.059
Muramoyltetrapeptide carboxypeptidase	0.551	0.679	0.419	0.457
N-acetylglucosamine-6-phosphate deacetylase	1.115	0.553	0.046	0.059
N-acetylmuramoyl-L-alanine amidase	1.101	0.527	0.038	0.059
N-acetylneuraminate lyase	1.115	0.553	0.046	0.059
N-acyl-D-amino-acid deacylase	0.087	0.625	0.890	0.890
N-acylglucosamine-6-phosphate 2-epimerase	1.115	0.553	0.046	0.059
N(6)-L-threonylcarbamoyladenine synthase	1.115	0.553	0.046	0.059
NAD(+) kinase	1.115	0.553	0.046	0.059
NAD(+) synthase	1.115	0.553	0.046	0.059
NAD(P)H dehydrogenase (quinone)	1.219	0.577	0.036	0.059
NADH:ubiquinone reductase (H(+)-translocating)	-0.115	0.694	0.868	0.882
Nickel-transporting ATPase	1.352	0.629	0.033	0.059
Nicotinamide-nucleotide amidase	1.115	0.553	0.046	0.059
Nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase	1.115	0.553	0.046	0.059
Nicotinate-nucleotide adenylyltransferase	1.115	0.553	0.046	0.059
Nicotinate-nucleotide diphosphorylase (carboxylating)	1.115	0.553	0.046	0.059
Nicotinate phosphoribosyltransferase	1.115	0.553	0.046	0.059
Nitrogenase	1.352	0.629	0.033	0.059
Nitronate monooxygenase	1.352	0.629	0.033	0.059
Non-specific serine/threonine protein kinase	1.127	0.569	0.049	0.062
O-acetylhomoserine aminocarboxypropyltransferase	0.802	0.500	0.111	0.133
Oligonucleotidase	1.115	0.553	0.046	0.059
Ornithine decarboxylase	1.289	0.586	0.029	0.059
Orotate phosphoribosyltransferase	1.115	0.553	0.046	0.059
Orotidine-5’-phosphate decarboxylase	1.078	0.528	0.043	0.059
Oxaloacetate decarboxylase	1.115	0.553	0.046	0.059
Pantetheine-phosphate adenylyltransferase	1.115	0.553	0.046	0.059
Pantothenate kinase	1.115	0.553	0.046	0.059
Peptide-methionine (R)-S-oxide reductase	1.223	0.582	0.037	0.059
Peptide-methionine (S)-S-oxide reductase	1.198	0.565	0.035	0.059
Peptide chain release factor N(5)-glutamine methyltransferase	1.115	0.553	0.046	0.059
Peptide deformylase	1.115	0.553	0.046	0.059
Peptidylprolyl isomerase	1.190	0.568	0.038	0.059
Peroxiredoxin	1.115	0.553	0.046	0.059
Phenylalanine–tRNA ligase	1.115	0.553	0.046	0.059
Phosphate-transporting ATPase	-0.298	0.779	0.702	0.720
Phosphate acetyltransferase	1.119	0.539	0.040	0.059
Phosphatidate cytidylyltransferase	1.136	0.569	0.048	0.061
Phosphatidylglycerophosphatase	1.115	0.553	0.046	0.059
Phosphatidylserine decarboxylase	1.115	0.553	0.046	0.059
Phospho-N-acetylmuramoyl-pentapeptide-transferase	1.115	0.553	0.046	0.059
Phosphoenolpyruvate–protein phosphotransferase	1.078	0.528	0.043	0.059
Phosphoenolpyruvate carboxykinase (ATP)	1.352	0.629	0.033	0.059
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)	1.115	0.553	0.046	0.059
Phosphoglucosamine mutase	1.115	0.553	0.046	0.059
Phosphoglycerate dehydrogenase	1.158	0.588	0.051	0.064
Phosphoglycerate kinase	1.115	0.553	0.046	0.059
Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)	1.250	0.613	0.043	0.059
Phosphoglycerate mutase (2,3-diphosphoglycerate-independent)	0.945	0.526	0.074	0.091
Phosphomethylpyrimidine kinase	1.115	0.553	0.046	0.059
Phosphomethylpyrimidine synthase	1.115	0.553	0.046	0.059
Phosphonate-transporting ATPase	1.352	0.629	0.033	0.059
Phosphopantothenate–cysteine ligase	1.115	0.553	0.046	0.059
Phosphopantothenoylcysteine decarboxylase	1.115	0.553	0.046	0.059
Phosphopentomutase	0.551	0.679	0.419	0.457
Phosphopyruvate hydratase	1.115	0.553	0.046	0.059
Phosphoribosylamine–glycine ligase	1.115	0.553	0.046	0.059
Phosphoribosylaminoimidazolecarboxamide formyltransferase	1.115	0.553	0.046	0.059
Phosphoribosylaminoimidazolesuccinocarboxamide synthase	1.115	0.553	0.046	0.059
Phosphoribosylformylglycinamidine cyclo-ligase	1.115	0.553	0.046	0.059
Phosphoribosylformylglycinamidine synthase	1.115	0.553	0.046	0.059
Phosphoribosylglycinamide formyltransferase	1.223	0.591	0.040	0.059
Phosphoserine phosphatase	1.115	0.553	0.046	0.059
Pimeloyl-[acyl-carrier protein] methyl ester esterase	1.115	0.553	0.046	0.059
Polar-amino-acid-transporting ATPase	0.954	0.514	0.065	0.081
Polyamine-transporting ATPase	1.115	0.553	0.046	0.059
Polyribonucleotide nucleotidyltransferase	1.115	0.553	0.046	0.059
Porphobilinogen synthase	1.115	0.553	0.046	0.059
Precorrin-2 C(20)-methyltransferase	1.115	0.553	0.046	0.059
Precorrin-2 dehydrogenase	1.115	0.553	0.046	0.059
Precorrin-3B C(17)-methyltransferase	1.115	0.553	0.046	0.059
Precorrin-4 C(11)-methyltransferase	1.115	0.553	0.046	0.059
Precorrin-6A reductase	1.115	0.553	0.046	0.059
Precorrin-8X methylmutase	1.115	0.553	0.046	0.059
Prephenate dehydratase	-0.298	0.779	0.702	0.720
Prepilin peptidase	1.115	0.553	0.046	0.059
Proline–tRNA ligase	1.115	0.553	0.046	0.059
Prolyl aminopeptidase	1.352	0.629	0.033	0.059
Propanal dehydrogenase (CoA-propanoylating)	1.219	0.577	0.036	0.059
Propanediol dehydratase	1.219	0.577	0.036	0.059
Propionate CoA-transferase	-0.298	0.779	0.702	0.720
Protein-N(pi)-phosphohistidine–sugar phosphotransferase	0.946	0.535	0.079	0.097
Protein-serine/threonine phosphatase	1.219	0.577	0.036	0.059
Purine-nucleoside phosphorylase	1.115	0.553	0.046	0.059
Pyridoxal 5’-phosphate synthase (glutamine hydrolyzing)	1.078	0.528	0.043	0.059
Pyridoxal kinase	-0.298	0.779	0.702	0.720
Pyroglutamyl-peptidase I	1.115	0.553	0.046	0.059
Pyrroline-5-carboxylate reductase	0.551	0.679	0.419	0.457
Pyruvate kinase	1.115	0.553	0.046	0.059
Pyruvate synthase	1.264	0.609	0.039	0.059
Pyruvate, phosphate dikinase	1.115	0.553	0.046	0.059
Quinolinate synthase	1.115	0.553	0.046	0.059
Repressor LexA	1.286	0.569	0.025	0.059
Riboflavin kinase	1.115	0.553	0.046	0.059
Riboflavin synthase	1.115	0.553	0.046	0.059
Ribokinase	0.551	0.679	0.419	0.457
Ribonuclease H	0.954	0.514	0.065	0.081
Ribonuclease III	1.115	0.553	0.046	0.059
Ribonuclease M5	1.115	0.553	0.046	0.059
Ribonuclease P	1.115	0.553	0.046	0.059
Ribonucleoside-diphosphate reductase	1.115	0.553	0.046	0.059
Ribonucleoside-triphosphate reductase	1.115	0.553	0.046	0.059
Ribose-5-phosphate isomerase	1.115	0.553	0.046	0.059
Ribose-phosphate diphosphokinase	1.115	0.553	0.046	0.059
Ribosomal-protein-alanine N-acetyltransferase	1.264	0.602	0.037	0.059
Ribulose-phosphate 3-epimerase	1.115	0.553	0.046	0.059
RNA helicase	1.115	0.553	0.046	0.059
S-adenosylmethionine:tRNA ribosyltransferase-isomerase	1.115	0.553	0.046	0.059
S-methyl-5-thioribose-1-phosphate isomerase	1.359	0.653	0.039	0.059
S-methyl-5-thioribose kinase	1.359	0.653	0.039	0.059
S-ribosylhomocysteine lyase	1.219	0.577	0.036	0.059
Selenide, water dikinase	0.551	0.679	0.419	0.457
Serine–tRNA ligase	1.115	0.553	0.046	0.059
Serine-type D-Ala-D-Ala carboxypeptidase	1.115	0.553	0.046	0.059
Serine O-acetyltransferase	-0.215	0.897	0.811	0.825
Shikimate dehydrogenase	1.286	0.613	0.038	0.059
Shikimate kinase	1.115	0.553	0.046	0.059
Short-chain acyl-CoA dehydrogenase	1.184	0.577	0.042	0.059
Signal peptidase I	1.115	0.553	0.046	0.059
Signal peptidase II	1.115	0.553	0.046	0.059
Sirohydrochlorin cobaltochelatase	1.115	0.553	0.046	0.059
Sirohydrochlorin ferrochelatase	1.115	0.553	0.046	0.059
Site-specific DNA-methyltransferase (adenine-specific)	1.093	0.527	0.040	0.059
Spore photoproduct lyase	1.115	0.553	0.046	0.059
Starch synthase	1.115	0.553	0.046	0.059
Succinate dehydrogenase (quinone)	0.551	0.679	0.419	0.457
Succinyl-diaminopimelate desuccinylase	1.115	0.553	0.046	0.059
Sulfoacetaldehyde dehydrogenase (acylating)	1.359	0.653	0.039	0.059
Sulfur carrier protein ThiS adenylyltransferase	1.115	0.553	0.046	0.059
Superoxide reductase	-0.298	0.779	0.702	0.720
Tetraacyldisaccharide 4’-kinase	1.115	0.553	0.046	0.059
Tetrahydrodipicolinate N-acetyltransferase	-0.298	0.779	0.702	0.720
Tetrahydrofolate synthase	1.115	0.553	0.046	0.059
Thiamine-phosphate diphosphorylase	1.223	0.582	0.037	0.059
Thiamine diphosphokinase	1.115	0.553	0.046	0.059
Thiazole synthase	1.115	0.553	0.046	0.059
Thioredoxin-disulfide reductase	1.115	0.553	0.046	0.059
Threonine–tRNA ligase	1.115	0.553	0.046	0.059
Threonine-phosphate decarboxylase	1.115	0.553	0.046	0.059
Threonine ammonia-lyase	1.119	0.539	0.040	0.059
Threonine synthase	0.087	0.625	0.890	0.890
Thymidylate synthase	1.115	0.553	0.046	0.059
Transketolase	1.115	0.553	0.046	0.059
Triacylglycerol lipase	1.352	0.629	0.033	0.059
Triose-phosphate isomerase	1.115	0.553	0.046	0.059
Tripeptide aminopeptidase	1.115	0.553	0.046	0.059
Triphosphoribosyl-dephospho-CoA synthase	1.289	0.586	0.029	0.059
tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase	1.115	0.553	0.046	0.059
tRNA-guanine(34) transglycosylase	1.115	0.553	0.046	0.059
tRNA (cytidine(34)-2’-O)-methyltransferase	1.115	0.553	0.046	0.059
tRNA (guanine(37)-N(1))-methyltransferase	1.115	0.553	0.046	0.059
tRNA (guanine(46)-N(7))-methyltransferase	1.078	0.528	0.043	0.059
tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase	1.115	0.553	0.046	0.059
tRNA dimethylallyltransferase	1.115	0.553	0.046	0.059
tRNA nucleotidyltransferase	-0.298	0.779	0.702	0.720
tRNA pseudouridine(38-40) synthase	1.115	0.553	0.046	0.059
tRNA pseudouridine(55) synthase	1.115	0.553	0.046	0.059
tRNA(Ile)-lysidine synthetase	1.115	0.553	0.046	0.059
Tryptophan–tRNA ligase	1.115	0.553	0.046	0.059
Tryptophan synthase	1.352	0.629	0.033	0.059
Tryptophanase	1.286	0.569	0.025	0.059
Type I site-specific deoxyribonuclease	1.223	0.578	0.036	0.059
Type II site-specific deoxyribonuclease	1.219	0.577	0.036	0.059
Type III site-specific deoxyribonuclease	0.915	0.466	0.051	0.064
Tyrosine–tRNA ligase	1.115	0.553	0.046	0.059
Tyrosine phenol-lyase	1.158	0.588	0.051	0.064
UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase	1.219	0.577	0.036	0.059
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	1.223	0.591	0.040	0.059
UDP-3-O-acyl-N-acetylglucosamine deacetylase	1.115	0.553	0.046	0.059
UDP-glucose–hexose-1-phosphate uridylyltransferase	1.115	0.553	0.046	0.059
UDP-glucose 4-epimerase	1.115	0.553	0.046	0.059
UDP-glucose 6-dehydrogenase	0.551	0.679	0.419	0.457
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	1.115	0.553	0.046	0.059
UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing)	0.802	0.500	0.111	0.133
UDP-N-acetylglucosamine diphosphorylase	1.115	0.553	0.046	0.059
UDP-N-acetylglucosamine kinase	1.219	0.577	0.036	0.059
UDP-N-acetylmuramate–L-alanine ligase	1.115	0.553	0.046	0.059
UDP-N-acetylmuramate dehydrogenase	1.115	0.553	0.046	0.059
UDP-N-acetylmuramoyl-L-alanine–D-glutamate ligase	1.115	0.553	0.046	0.059
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase	1.115	0.553	0.046	0.059
UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase	1.078	0.528	0.043	0.059
UMP kinase	1.115	0.553	0.046	0.059
UMP/CMP kinase	1.115	0.553	0.046	0.059
Undecaprenyl-diphosphate phosphatase	1.115	0.553	0.046	0.059
Uracil-DNA glycosylase	1.115	0.553	0.046	0.059
Uracil phosphoribosyltransferase	1.223	0.582	0.037	0.059
Uridine kinase	-0.298	0.779	0.702	0.720
Uridine phosphorylase	-1.604	1.840	0.385	0.455
Urocanate hydratase	1.223	0.591	0.040	0.059
Urocanate reductase	0.551	0.679	0.419	0.457
Uroporphyrinogen-III C-methyltransferase	1.115	0.553	0.046	0.059
Uroporphyrinogen-III synthase	1.115	0.553	0.046	0.059
UTP–glucose-1-phosphate uridylyltransferase	1.115	0.553	0.046	0.059
Valine–tRNA ligase	1.115	0.553	0.046	0.059
Vinylacetyl-CoA Delta-isomerase	-1.604	1.840	0.385	0.455
Xaa-Pro aminopeptidase	1.115	0.553	0.046	0.059
Xaa-Pro dipeptidase	1.115	0.553	0.046	0.059
Xanthine phosphoribosyltransferase	-0.298	0.779	0.702	0.720
XTP/dITP diphosphatase	-0.298	0.779	0.702	0.720
Zinc-exporting ATPase	1.115	0.553	0.046	0.059

# merge with tb.ra for full results table
full.res <- left_join(tb.ra, results.out, by = "description")

write.csv(full.res, "output/picrust_ec_stratefied_fuso_data_results.csv", row.names = F)

Part 2 KO Data

descriptions <- readr::read_tsv("data/PICRUST/ko_pred_metagenome_unstrat_descrip.tsv")[,1:2] %>%
  distinct()

-- Column specification --------------------------------------------------------
cols(
  .default = col_double(),
  `function` = col_character(),
  description = col_character()
)
i Use `spec()` for the full column specifications.

colnames(descriptions) <- c("func", "description")

pi.dat <- readxl::read_xlsx("data/PICRUST-Stratified/KO_fuso.xlsx")
colnames(pi.dat) <- c("func",  colnames(pi.dat)[-c(1)])

# add descriptions to dataframe
pi.dat <- left_join(pi.dat, descriptions, by="func")
pi.dat <- pi.dat[,c(1,161,3:160)]

# aggregate descriptions to get 1 description per row - unique;y defined.
pi.dat <- pi.dat %>%
  group_by(description) %>%
  summarise(across(`X1.S37.Jun172016`:`X99.D01.S37.Jun232016`,.fns = sum))

# make long format
pi.dat <- pi.dat %>%
  pivot_longer(
    cols=`X1.S37.Jun172016`:`X99.D01.S37.Jun232016`,
    names_to = "ID",
    values_to = "Abundance"
  ) %>%
  mutate(
    ID = substr(ID, 2, 99)
  )

d <- as.data.frame(dat.16s)
mydata <- full_join(pi.dat, d)

Joining, by = "ID"

Warning in class(x) <- c(setdiff(subclass, tibble_class), tibble_class): Setting
class(x) to multiple strings ("tbl_df", "tbl", ...); result will no longer be an
S4 object

mydata <- mydata %>%
  mutate(
    ID.n = as.numeric(as.factor(ID)),
    description.n = as.numeric(as.factor(description))
  ) %>%
  group_by(ID) %>%
  mutate(
    dem = ifelse(sum(Abundance)==0, 1, sum(Abundance)),
    RelAbundance = Abundance/dem*100) %>%
  ungroup()%>%
  group_by(description)%>%
  mutate(avgRA = mean(RelAbundance))

Abundance

# Run on all descriptions
tb.ra1 <- mydata %>%
  group_by(description) %>%
  summarise(ng = n(),
            Overall.M = mean(RelAbundance),
            Overall.SE = sd(RelAbundance)/sqrt(ng))
tb.ra2m <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(M = mean(RelAbundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = M)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2se <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(),SE = sd(RelAbundance)/sqrt(ng)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = SE)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2var <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n(), VAR = var(RelAbundance)) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = VAR)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra2ng <- mydata %>%
  group_by(description, tumor.cat) %>%
  summarise(ng=n()) %>%
  pivot_wider(id_cols = description,
              names_from = tumor.cat,
              values_from = ng)

`summarise()` has grouped output by 'description'. You can override using the `.groups` argument.

tb.ra <- left_join(tb.ra1, tb.ra2m)

Joining, by = "description"

tb.ra <- cbind(tb.ra, tb.ra2se[,-1])
tb.ra <- cbind(tb.ra, tb.ra2var[,-1])
tb.ra <- cbind(tb.ra, tb.ra2ng[,-1]) 

colnames(tb.ra) <- c("description", "ng", "Overall Mean", "Overall SE", "Non-Tumor Mean", "Tumor Mean", "Non-Tumor SE", "Tumor SE","Non-Tumor Var", "Tumor Var", "Non-Tumor Ng", "Tumor Ng")
tb.ra <- tb.ra %>%
  arrange(desc(`Overall Mean`))
tb.ra <- tb.ra[, c("description", "Overall Mean", "Overall SE","Tumor Mean","Tumor Var", "Tumor SE","Tumor Ng", "Non-Tumor Mean","Non-Tumor Var", "Non-Tumor SE", "Non-Tumor Ng")]

# compute t-test
tb.ra <- tb.ra %>%
  mutate(
    SEpooled = sqrt(`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`),
    t = (`Tumor Mean` - `Non-Tumor Mean`)/(SEpooled),
    df = ((`Tumor Var`/`Tumor Ng` + `Non-Tumor Var`/`Non-Tumor Ng`)**2)/(((`Tumor Var`/`Tumor Ng`)**2)/(`Tumor Ng`-1) + ((`Non-Tumor Var`/`Non-Tumor Ng`)**2)/(`Non-Tumor Ng`-1)),
    p = pt(q = abs(t), df=df, lower.tail = F)*2,
    fdr_p = p.adjust(p, method="fdr")
  )
kable(tb.ra, format="html", digits=5, caption="Stratefied KO Data - Fusobacterium nucleatum: Average RelAbundance of Each Description (sorted in descending order)") %>%
  kable_styling(full_width = T) %>%
  scroll_box(width = "100%", height="600px")

Stratefied KO Data - Fusobacterium nucleatum: Average RelAbundance of Each Description (sorted in descending order)

description	Overall Mean	Overall SE	Tumor Mean	Tumor Var	Tumor SE	Tumor Ng	Non-Tumor Mean	Non-Tumor Var	Non-Tumor SE	Non-Tumor Ng	SEpooled	t	df	p	fdr_p
ABC.PE.S; peptide/nickel transport system substrate-binding protein	0.32182	0.02961	0.38772	0.13926	0.04629	65	0.27577	0.13424	0.03799	93	0.05988	1.86944	136.261	0.06371	0.09054
ytmI; uncharacterized N-acetyltransferase [EC:2.3.1.-]	0.26445	0.02557	0.32937	0.10990	0.04112	65	0.21908	0.09476	0.03192	93	0.05206	2.11859	131.229	0.03601	0.08455
ABC.PE.A1; peptide/nickel transport system ATP-binding protein	0.24038	0.02284	0.29790	0.08729	0.03665	65	0.20018	0.07597	0.02858	93	0.04647	2.10258	131.654	0.03741	0.08455
ABCB-BAC; ATP-binding cassette, subfamily B, bacterial	0.23411	0.02158	0.28406	0.07543	0.03407	65	0.19919	0.07006	0.02745	93	0.04375	1.94004	134.606	0.05447	0.08455
ABC.FEV.A; iron complex transport system ATP-binding protein [EC:3.6.3.34]	0.21250	0.02004	0.26080	0.06669	0.03203	65	0.17873	0.05905	0.02520	93	0.04075	2.01366	132.438	0.04607	0.08455
TC.AGCS; alanine or glycine:cation symporter, AGCS family	0.20856	0.01919	0.25266	0.05926	0.03019	65	0.17774	0.05570	0.02447	93	0.03887	1.92763	135.134	0.05600	0.08455
ABC.FEV.P; iron complex transport system permease protein	0.20755	0.01981	0.25488	0.06543	0.03173	65	0.17446	0.05763	0.02489	93	0.04033	1.99408	132.199	0.04820	0.08455
ABC.PE.P; peptide/nickel transport system permease protein	0.20607	0.01974	0.25494	0.06535	0.03171	65	0.17191	0.05677	0.02471	93	0.04020	2.06552	131.569	0.04084	0.08455
ABC.PE.P1; peptide/nickel transport system permease protein	0.20607	0.01974	0.25494	0.06535	0.03171	65	0.17191	0.05677	0.02471	93	0.04020	2.06552	131.569	0.04084	0.08455
fhaB; filamentous hemagglutinin	0.20068	0.02023	0.25467	0.06846	0.03245	65	0.16295	0.05917	0.02522	93	0.04110	2.23133	131.338	0.02735	0.08455
ABC.FEV.S; iron complex transport system substrate-binding protein	0.19731	0.01924	0.24339	0.06240	0.03098	65	0.16510	0.05390	0.02407	93	0.03924	1.99538	131.308	0.04807	0.08455
pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3]	0.17046	0.01666	0.21188	0.04677	0.02683	65	0.14151	0.04020	0.02079	93	0.03394	2.07330	131.082	0.04010	0.08455
TC.FEV.OM; iron complex outermembrane recepter protein	0.15281	0.01443	0.18626	0.03437	0.02300	65	0.12943	0.03092	0.01823	93	0.02935	1.93660	133.156	0.05491	0.08455
por, nifJ; pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-]	0.14651	0.01590	0.18292	0.04375	0.02594	65	0.12106	0.03612	0.01971	93	0.03258	1.89870	129.228	0.05983	0.08687
nhaC; Na+:H+ antiporter, NhaC family	0.13893	0.01374	0.16897	0.03168	0.02208	65	0.11793	0.02779	0.01729	93	0.02804	1.82029	132.006	0.07098	0.09932
K07485; transposase	0.13139	0.01544	0.16938	0.04235	0.02552	65	0.10483	0.03310	0.01887	93	0.03174	2.03394	126.715	0.04405	0.08455
ABC.CD.P; putative ABC transport system permease protein	0.12961	0.01217	0.16056	0.02472	0.01950	65	0.10797	0.02157	0.01523	93	0.02474	2.12512	131.767	0.03544	0.08455
ABC.PE.A; peptide/nickel transport system ATP-binding protein	0.12961	0.01217	0.16056	0.02472	0.01950	65	0.10797	0.02157	0.01523	93	0.02474	2.12512	131.767	0.03544	0.08455
K07133; uncharacterized protein	0.12579	0.01209	0.15493	0.02426	0.01932	65	0.10543	0.02154	0.01522	93	0.02460	2.01241	132.562	0.04620	0.08455
pbuG; putative MFS transporter, AGZA family, xanthine/uracil permease	0.11703	0.01138	0.14338	0.02143	0.01816	65	0.09862	0.01916	0.01435	93	0.02315	1.93378	132.877	0.05527	0.08455
gltS; glutamate:Na+ symporter, ESS family	0.11691	0.01088	0.14086	0.01883	0.01702	65	0.10016	0.01812	0.01396	93	0.02201	1.84909	136.202	0.06661	0.09385
hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	0.11326	0.01055	0.13506	0.01722	0.01628	65	0.09803	0.01745	0.01370	93	0.02127	1.74049	138.462	0.08399	0.11687
mnmA, trmU; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]	0.10684	0.00982	0.12920	0.01546	0.01542	65	0.09121	0.01462	0.01254	93	0.01988	1.91114	135.408	0.05810	0.08455
xerD; integrase/recombinase XerD	0.10684	0.00982	0.12920	0.01546	0.01542	65	0.09121	0.01462	0.01254	93	0.01988	1.91114	135.408	0.05810	0.08455
aroE; shikimate dehydrogenase [EC:1.1.1.25]	0.10566	0.01077	0.13160	0.01979	0.01745	65	0.08752	0.01672	0.01341	93	0.02201	2.00272	130.299	0.04728	0.08455
K07487; transposase	0.10213	0.01341	0.12830	0.03233	0.02230	65	0.08384	0.02519	0.01646	93	0.02772	1.60410	126.567	0.11118	0.14417
recG; ATP-dependent DNA helicase RecG [EC:3.6.4.12]	0.10172	0.00941	0.12346	0.01431	0.01484	65	0.08653	0.01337	0.01199	93	0.01908	1.93575	134.886	0.05499	0.08455
ABC.CD.A; putative ABC transport system ATP-binding protein	0.10042	0.00929	0.12334	0.01428	0.01482	65	0.08439	0.01273	0.01170	93	0.01888	2.06288	132.737	0.04107	0.08455
relE, stbE; mRNA interferase RelE/StbE	0.09764	0.00996	0.12330	0.01686	0.01611	65	0.07970	0.01423	0.01237	93	0.02031	2.14654	130.253	0.03368	0.08455
ACADS, bcd; butyryl-CoA dehydrogenase [EC:1.3.8.1]	0.09165	0.00862	0.11179	0.01226	0.01373	65	0.07758	0.01103	0.01089	93	0.01753	1.95233	133.157	0.05300	0.08455
ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]	0.09165	0.00862	0.11179	0.01226	0.01373	65	0.07758	0.01103	0.01089	93	0.01753	1.95233	133.157	0.05300	0.08455
ABC.PA.S; polar amino acid transport system substrate-binding protein	0.09153	0.00889	0.10928	0.01248	0.01386	65	0.07912	0.01227	0.01149	93	0.01800	1.67572	137.132	0.09607	0.13146
SPP; sucrose-6-phosphatase [EC:3.1.3.24]	0.09050	0.00948	0.10370	0.01238	0.01380	65	0.08127	0.01543	0.01288	93	0.01888	1.18832	146.656	0.23663	0.27692
pepD; dipeptidase D [EC:3.4.13.-]	0.08523	0.00833	0.10594	0.01169	0.01341	65	0.07076	0.01005	0.01040	93	0.01697	2.07330	131.082	0.04010	0.08455
bigA; putative surface-exposed virulence protein	0.08467	0.00979	0.10907	0.01691	0.01613	65	0.06761	0.01334	0.01198	93	0.02009	2.06373	127.139	0.04108	0.08455
K06867; uncharacterized protein	0.08171	0.01073	0.10264	0.02069	0.01784	65	0.06707	0.01612	0.01317	93	0.02217	1.60410	126.567	0.11118	0.14417
patB, malY; cystathione beta-lyase [EC:4.4.1.8]	0.08129	0.00766	0.09780	0.00933	0.01198	65	0.06976	0.00903	0.00985	93	0.01551	1.80783	136.443	0.07284	0.10158
sigH; RNA polymerase sporulation-specific sigma factor	0.08129	0.00766	0.09780	0.00933	0.01198	65	0.06976	0.00903	0.00985	93	0.01551	1.80783	136.443	0.07284	0.10158
waaF, rfaF; heptosyltransferase II [EC:2.4.-.-]	0.07999	0.00750	0.09768	0.00931	0.01197	65	0.06762	0.00832	0.00946	93	0.01525	1.97068	132.893	0.05084	0.08455
afuA, fbpA; iron(III) transport system substrate-binding protein	0.07868	0.00743	0.09757	0.00929	0.01196	65	0.06548	0.00800	0.00927	93	0.01513	2.12060	131.145	0.03584	0.08455
PTS-Ntr-EIIA, ptsN; PTS system, nitrogen regulatory IIA component [EC:2.7.1.-]	0.07634	0.00715	0.09188	0.00812	0.01118	65	0.06549	0.00783	0.00918	93	0.01446	1.82475	136.284	0.07023	0.09838
uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12]	0.07634	0.00715	0.09188	0.00812	0.01118	65	0.06549	0.00783	0.00918	93	0.01446	1.82475	136.284	0.07023	0.09838
K01436; amidohydrolase [EC:3.5.1.-]	0.07618	0.00736	0.09206	0.00861	0.01151	65	0.06508	0.00830	0.00945	93	0.01489	1.81179	136.297	0.07222	0.10094
hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]	0.07357	0.00710	0.09183	0.00857	0.01148	65	0.06080	0.00724	0.00882	93	0.01448	2.14272	130.255	0.03400	0.08455
cysK; cysteine synthase A [EC:2.5.1.47]	0.07226	0.00712	0.09171	0.00856	0.01147	65	0.05866	0.00726	0.00884	93	0.01448	2.28212	130.523	0.02410	0.08455
AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
ABC.SS.P; simple sugar transport system permease protein	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
alr; alanine racemase [EC:5.1.1.1]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
chrA; chromate transporter	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
cobQ, cbiP; adenosylcobyric acid synthase [EC:6.3.5.10]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
E4.2.1.46, rfbB, rffG; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
exbB; biopolymer transport protein ExbB	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
exbD; biopolymer transport protein ExbD	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
fldA, nifF, isiB; flavodoxin I	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
fusA, GFM, EFG; elongation factor G	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
gidA, mnmG, MTO1; tRNA uridine 5-carboxymethylaminomethyl modification enzyme	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
glgC; glucose-1-phosphate adenylyltransferase [EC:2.7.7.27]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
K07010; putative glutamine amidotransferase	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
K08303; putative protease [EC:3.4.-.-]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
KAE1, tsaD, QRI7; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
ldhA; D-lactate dehydrogenase [EC:1.1.1.28]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
mreB; rod shape-determining protein MreB and related proteins	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
nudF; ADP-ribose pyrophosphatase [EC:3.6.1.13]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
relA; GTP pyrophosphokinase [EC:2.7.6.5]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
TC.LIVCS; branched-chain amino acid:cation transporter, LIVCS family	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
TC.NSS; neurotransmitter:Na+ symporter, NSS family	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
thiJ; protein deglycase [EC:3.5.1.124]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
tonB; periplasmic protein TonB	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
trkA, ktrA; trk system potassium uptake protein	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
trkH, trkG, ktrB; trk system potassium uptake protein	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9]	0.07123	0.00654	0.08613	0.00687	0.01028	65	0.06081	0.00650	0.00836	93	0.01325	1.91114	135.408	0.05810	0.08455
afuB, fbpB; iron(III) transport system permease protein	0.06992	0.00645	0.08602	0.00686	0.01027	65	0.05867	0.00614	0.00813	93	0.01310	2.08837	132.991	0.03867	0.08455
afuC, fbpC; iron(III) transport system ATP-binding protein [EC:3.6.3.30]	0.06992	0.00645	0.08602	0.00686	0.01027	65	0.05867	0.00614	0.00813	93	0.01310	2.08837	132.991	0.03867	0.08455
sepF; cell division inhibitor SepF	0.06992	0.00645	0.08602	0.00686	0.01027	65	0.05867	0.00614	0.00813	93	0.01310	2.08837	132.991	0.03867	0.08455
waaY, rfaY; heptose II phosphotransferase [EC:2.7.1.-]	0.06992	0.00645	0.08602	0.00686	0.01027	65	0.05867	0.00614	0.00813	93	0.01310	2.08837	132.991	0.03867	0.08455
bshA; L-malate glycosyltransferase [EC:2.4.1.-]	0.06611	0.00619	0.08039	0.00620	0.00977	65	0.05613	0.00577	0.00787	93	0.01254	1.93438	134.677	0.05516	0.08455
dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]	0.06611	0.00619	0.08039	0.00620	0.00977	65	0.05613	0.00577	0.00787	93	0.01254	1.93438	134.677	0.05516	0.08455
E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	0.06611	0.00619	0.08039	0.00620	0.00977	65	0.05613	0.00577	0.00787	93	0.01254	1.93438	134.677	0.05516	0.08455
pgsA, PGS1; CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	0.06611	0.00619	0.08039	0.00620	0.00977	65	0.05613	0.00577	0.00787	93	0.01254	1.93438	134.677	0.05516	0.08455
smf; DNA processing protein	0.06611	0.00619	0.08039	0.00620	0.00977	65	0.05613	0.00577	0.00787	93	0.01254	1.93438	134.677	0.05516	0.08455
znuA; zinc transport system substrate-binding protein	0.06611	0.00619	0.08039	0.00620	0.00977	65	0.05613	0.00577	0.00787	93	0.01254	1.93438	134.677	0.05516	0.08455
APRT, apt; adenine phosphoribosyltransferase [EC:2.4.2.7]	0.06480	0.00608	0.08028	0.00618	0.00975	65	0.05399	0.00539	0.00761	93	0.01237	2.12512	131.767	0.03544	0.08455
ccdA; cytochrome c-type biogenesis protein	0.06480	0.00608	0.08028	0.00618	0.00975	65	0.05399	0.00539	0.00761	93	0.01237	2.12512	131.767	0.03544	0.08455
E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]	0.06480	0.00608	0.08028	0.00618	0.00975	65	0.05399	0.00539	0.00761	93	0.01237	2.12512	131.767	0.03544	0.08455
fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]	0.06480	0.00608	0.08028	0.00618	0.00975	65	0.05399	0.00539	0.00761	93	0.01237	2.12512	131.767	0.03544	0.08455
GLO1, gloA; lactoylglutathione lyase [EC:4.4.1.5]	0.06480	0.00608	0.08028	0.00618	0.00975	65	0.05399	0.00539	0.00761	93	0.01237	2.12512	131.767	0.03544	0.08455
hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]	0.06480	0.00608	0.08028	0.00618	0.00975	65	0.05399	0.00539	0.00761	93	0.01237	2.12512	131.767	0.03544	0.08455
msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12]	0.06480	0.00608	0.08028	0.00618	0.00975	65	0.05399	0.00539	0.00761	93	0.01237	2.12512	131.767	0.03544	0.08455
murJ, mviN; putative peptidoglycan lipid II flippase	0.06480	0.00608	0.08028	0.00618	0.00975	65	0.05399	0.00539	0.00761	93	0.01237	2.12512	131.767	0.03544	0.08455
mutT, NUDT15, MTH2; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]	0.06480	0.00608	0.08028	0.00618	0.00975	65	0.05399	0.00539	0.00761	93	0.01237	2.12512	131.767	0.03544	0.08455
rfbC, rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]	0.06480	0.00608	0.08028	0.00618	0.00975	65	0.05399	0.00539	0.00761	93	0.01237	2.12512	131.767	0.03544	0.08455
sppA; protease IV [EC:3.4.21.-]	0.06480	0.00608	0.08028	0.00618	0.00975	65	0.05399	0.00539	0.00761	93	0.01237	2.12512	131.767	0.03544	0.08455
thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]	0.06480	0.00608	0.08028	0.00618	0.00975	65	0.05399	0.00539	0.00761	93	0.01237	2.12512	131.767	0.03544	0.08455
xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]	0.06480	0.00608	0.08028	0.00618	0.00975	65	0.05399	0.00539	0.00761	93	0.01237	2.12512	131.767	0.03544	0.08455
E5.2.1.8; peptidylprolyl isomerase [EC:5.2.1.8]	0.06350	0.00609	0.08016	0.00616	0.00974	65	0.05185	0.00539	0.00761	93	0.01236	2.29065	131.900	0.02357	0.08455
K07483; transposase	0.06350	0.00609	0.08016	0.00616	0.00974	65	0.05185	0.00539	0.00761	93	0.01236	2.29065	131.900	0.02357	0.08455
abgT; aminobenzoyl-glutamate transport protein	0.06246	0.00599	0.07458	0.00571	0.00937	65	0.05399	0.00552	0.00770	93	0.01213	1.69746	136.397	0.09189	0.12588
galE, GALE; UDP-glucose 4-epimerase [EC:5.1.3.2]	0.06246	0.00599	0.07458	0.00571	0.00937	65	0.05399	0.00552	0.00770	93	0.01213	1.69746	136.397	0.09189	0.12588
K06915; uncharacterized protein	0.06128	0.00805	0.07698	0.01164	0.01338	65	0.05030	0.00907	0.00987	93	0.01663	1.60410	126.567	0.11118	0.14417
K06926; uncharacterized protein	0.06128	0.00805	0.07698	0.01164	0.01338	65	0.05030	0.00907	0.00987	93	0.01663	1.60410	126.567	0.11118	0.14417
K07486; transposase	0.06128	0.00805	0.07698	0.01164	0.01338	65	0.05030	0.00907	0.00987	93	0.01663	1.60410	126.567	0.11118	0.14417
bdhAB; butanol dehydrogenase [EC:1.1.1.-]	0.06116	0.00587	0.07447	0.00569	0.00936	65	0.05185	0.00514	0.00743	93	0.01195	1.89299	133.318	0.06053	0.08778
cbiN; cobalt/nickel transport protein	0.05968	0.00601	0.07454	0.00608	0.00967	65	0.04931	0.00524	0.00751	93	0.01224	2.06130	131.220	0.04125	0.08455
ABC.PA.P; polar amino acid transport system permease protein	0.05956	0.00637	0.07202	0.00692	0.01032	65	0.05085	0.00593	0.00799	93	0.01305	1.62227	130.978	0.10715	0.14417
ABCC-BAC; ATP-binding cassette, subfamily C, bacterial	0.05838	0.00601	0.07442	0.00606	0.00965	65	0.04717	0.00522	0.00749	93	0.01222	2.23029	131.192	0.02743	0.08455
cysS1; cysteinyl-tRNA synthetase, unknown class [EC:6.1.1.16]	0.05838	0.00601	0.07442	0.00606	0.00965	65	0.04717	0.00522	0.00749	93	0.01222	2.23029	131.192	0.02743	0.08455
K07005; uncharacterized protein	0.05838	0.00601	0.07442	0.00606	0.00965	65	0.04717	0.00522	0.00749	93	0.01222	2.23029	131.192	0.02743	0.08455
amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	0.05826	0.00627	0.07191	0.00691	0.01031	65	0.04872	0.00555	0.00773	93	0.01289	1.79978	127.953	0.07425	0.10343
fixA, etfB; electron transfer flavoprotein beta subunit	0.05734	0.00561	0.06884	0.00508	0.00884	65	0.04931	0.00480	0.00718	93	0.01139	1.71491	135.349	0.08865	0.12307
fixB, etfA; electron transfer flavoprotein alpha subunit	0.05734	0.00561	0.06884	0.00508	0.00884	65	0.04931	0.00480	0.00718	93	0.01139	1.71491	135.349	0.08865	0.12307
atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]	0.05604	0.00548	0.06873	0.00506	0.00882	65	0.04717	0.00439	0.00687	93	0.01118	1.92751	131.556	0.05607	0.08455
atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]	0.05604	0.00548	0.06873	0.00506	0.00882	65	0.04717	0.00439	0.00687	93	0.01118	1.92751	131.556	0.05607	0.08455
dinJ; DNA-damage-inducible protein J	0.05604	0.00548	0.06873	0.00506	0.00882	65	0.04717	0.00439	0.00687	93	0.01118	1.92751	131.556	0.05607	0.08455
ecfA2; energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-]	0.05604	0.00548	0.06873	0.00506	0.00882	65	0.04717	0.00439	0.00687	93	0.01118	1.92751	131.556	0.05607	0.08455
hepST; heptaprenyl diphosphate synthase [EC:2.5.1.30]	0.05604	0.00548	0.06873	0.00506	0.00882	65	0.04717	0.00439	0.00687	93	0.01118	1.92751	131.556	0.05607	0.08455
hutH, HAL; histidine ammonia-lyase [EC:4.3.1.3]	0.05604	0.00548	0.06873	0.00506	0.00882	65	0.04717	0.00439	0.00687	93	0.01118	1.92751	131.556	0.05607	0.08455
hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7]	0.05604	0.00548	0.06873	0.00506	0.00882	65	0.04717	0.00439	0.00687	93	0.01118	1.92751	131.556	0.05607	0.08455
hutU, UROC1; urocanate hydratase [EC:4.2.1.49]	0.05604	0.00548	0.06873	0.00506	0.00882	65	0.04717	0.00439	0.00687	93	0.01118	1.92751	131.556	0.05607	0.08455
lon; ATP-dependent Lon protease [EC:3.4.21.53]	0.05604	0.00548	0.06873	0.00506	0.00882	65	0.04717	0.00439	0.00687	93	0.01118	1.92751	131.556	0.05607	0.08455
lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191]	0.05604	0.00548	0.06873	0.00506	0.00882	65	0.04717	0.00439	0.00687	93	0.01118	1.92751	131.556	0.05607	0.08455
purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]	0.05604	0.00548	0.06873	0.00506	0.00882	65	0.04717	0.00439	0.00687	93	0.01118	1.92751	131.556	0.05607	0.08455
recO; DNA repair protein RecO (recombination protein O)	0.05604	0.00548	0.06873	0.00506	0.00882	65	0.04717	0.00439	0.00687	93	0.01118	1.92751	131.556	0.05607	0.08455
TC.GNTP; gluconate:H+ symporter, GntP family	0.05604	0.00548	0.06873	0.00506	0.00882	65	0.04717	0.00439	0.00687	93	0.01118	1.92751	131.556	0.05607	0.08455
yuiF; putative amino acid transporter	0.05604	0.00548	0.06873	0.00506	0.00882	65	0.04717	0.00439	0.00687	93	0.01118	1.92751	131.556	0.05607	0.08455
fucO; lactaldehyde reductase [EC:1.1.1.77]	0.05473	0.00548	0.06861	0.00504	0.00881	65	0.04503	0.00437	0.00685	93	0.01116	2.11346	131.436	0.03645	0.08455
npdA; NAD-dependent deacetylase [EC:3.5.1.-]	0.05314	0.00582	0.06617	0.00606	0.00965	65	0.04403	0.00472	0.00712	93	0.01200	1.84500	126.539	0.06738	0.09471
NTH; endonuclease III [EC:4.2.99.18]	0.05314	0.00582	0.06617	0.00606	0.00965	65	0.04403	0.00472	0.00712	93	0.01200	1.84500	126.539	0.06738	0.09471
K07052; uncharacterized protein	0.05092	0.00541	0.06299	0.00500	0.00877	65	0.04249	0.00425	0.00676	93	0.01107	1.85078	130.566	0.06646	0.09374
oppF; oligopeptide transport system ATP-binding protein	0.05092	0.00541	0.06299	0.00500	0.00877	65	0.04249	0.00425	0.00676	93	0.01107	1.85078	130.566	0.06646	0.09374
PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]	0.05092	0.00541	0.06299	0.00500	0.00877	65	0.04249	0.00425	0.00676	93	0.01107	1.85078	130.566	0.06646	0.09374
ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:3.6.3.21]	0.05080	0.00507	0.06047	0.00407	0.00791	65	0.04404	0.00398	0.00655	93	0.01027	1.60007	136.928	0.11189	0.14478
metQ; D-methionine transport system substrate-binding protein	0.05080	0.00507	0.06047	0.00407	0.00791	65	0.04404	0.00398	0.00655	93	0.01027	1.60007	136.928	0.11189	0.14478
E4.3.1.4; formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4]	0.04962	0.00541	0.06287	0.00498	0.00875	65	0.04035	0.00420	0.00672	93	0.01104	2.04035	130.235	0.04334	0.08455
fctD; glutamate formiminotransferase [EC:2.1.2.5]	0.04962	0.00541	0.06287	0.00498	0.00875	65	0.04035	0.00420	0.00672	93	0.01104	2.04035	130.235	0.04334	0.08455
metB; cystathionine gamma-synthase [EC:2.5.1.48]	0.04962	0.00541	0.06287	0.00498	0.00875	65	0.04035	0.00420	0.00672	93	0.01104	2.04035	130.235	0.04334	0.08455
rimJ; [ribosomal protein S5]-alanine N-acetyltransferase [EC:2.3.1.267]	0.04962	0.00541	0.06287	0.00498	0.00875	65	0.04035	0.00420	0.00672	93	0.01104	2.04035	130.235	0.04334	0.08455
murI; glutamate racemase [EC:5.1.1.3]	0.04949	0.00493	0.06036	0.00406	0.00791	65	0.04190	0.00357	0.00620	93	0.01005	1.83709	132.118	0.06844	0.09610
K07497; putative transposase	0.04672	0.00567	0.06031	0.00577	0.00942	65	0.03721	0.00443	0.00690	93	0.01168	1.97770	125.960	0.05015	0.08455
K07090; uncharacterized protein	0.04585	0.00495	0.05455	0.00382	0.00767	65	0.03977	0.00385	0.00644	93	0.01001	1.47649	138.233	0.14209	0.18328
ABC.X4.S; putative ABC transport system substrate-binding protein	0.04568	0.00454	0.05473	0.00326	0.00708	65	0.03936	0.00318	0.00585	93	0.00918	1.67382	136.753	0.09645	0.13183
ABC.X4.A; putative ABC transport system ATP-binding protein	0.04438	0.00436	0.05462	0.00325	0.00707	65	0.03722	0.00275	0.00544	93	0.00892	1.95008	130.293	0.05331	0.08455
ABC.X4.P; putative ABC transport system permease protein	0.04438	0.00436	0.05462	0.00325	0.00707	65	0.03722	0.00275	0.00544	93	0.00892	1.95008	130.293	0.05331	0.08455
arsR; ArsR family transcriptional regulator, arsenate/arsenite/antimonite-responsive transcriptional repressor	0.04438	0.00436	0.05462	0.00325	0.00707	65	0.03722	0.00275	0.00544	93	0.00892	1.95008	130.293	0.05331	0.08455
E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	0.04438	0.00436	0.05462	0.00325	0.00707	65	0.03722	0.00275	0.00544	93	0.00892	1.95008	130.293	0.05331	0.08455
hsdM; type I restriction enzyme M protein [EC:2.1.1.72]	0.04438	0.00436	0.05462	0.00325	0.00707	65	0.03722	0.00275	0.00544	93	0.00892	1.95008	130.293	0.05331	0.08455
iscS, NFS1; cysteine desulfurase [EC:2.8.1.7]	0.04438	0.00436	0.05462	0.00325	0.00707	65	0.03722	0.00275	0.00544	93	0.00892	1.95008	130.293	0.05331	0.08455
lpxL, htrB; Kdo2-lipid IVA lauroyltransferase [EC:2.3.1.241]	0.04438	0.00436	0.05462	0.00325	0.00707	65	0.03722	0.00275	0.00544	93	0.00892	1.95008	130.293	0.05331	0.08455
rnj; ribonuclease J [EC:3.1.-.-]	0.04438	0.00436	0.05462	0.00325	0.00707	65	0.03722	0.00275	0.00544	93	0.00892	1.95008	130.293	0.05331	0.08455
ABC-2.P; ABC-2 type transport system permease protein	0.04346	0.00554	0.05155	0.00522	0.00896	65	0.03781	0.00456	0.00700	93	0.01137	1.20814	131.818	0.22916	0.26869
nfdA; N-substituted formamide deformylase [EC:3.5.1.91]	0.04346	0.00554	0.05155	0.00522	0.00896	65	0.03781	0.00456	0.00700	93	0.01137	1.20814	131.818	0.22916	0.26869
lexA; repressor LexA [EC:3.4.21.88]	0.04307	0.00435	0.05450	0.00325	0.00707	65	0.03508	0.00269	0.00538	93	0.00888	2.18661	129.457	0.03057	0.08455
tnaA; tryptophanase [EC:4.1.99.1]	0.04307	0.00435	0.05450	0.00325	0.00707	65	0.03508	0.00269	0.00538	93	0.00888	2.18661	129.457	0.03057	0.08455
bioB; biotin synthase [EC:2.8.1.6]	0.04204	0.00416	0.04892	0.00249	0.00619	65	0.03722	0.00288	0.00556	93	0.00833	1.40512	143.833	0.16214	0.20425
cspA; cold shock protein (beta-ribbon, CspA family)	0.04204	0.00416	0.04892	0.00249	0.00619	65	0.03722	0.00288	0.00556	93	0.00833	1.40512	143.833	0.16214	0.20425
hupB; DNA-binding protein HU-beta	0.04204	0.00416	0.04892	0.00249	0.00619	65	0.03722	0.00288	0.00556	93	0.00833	1.40512	143.833	0.16214	0.20425
K07137; uncharacterized protein	0.04204	0.00416	0.04892	0.00249	0.00619	65	0.03722	0.00288	0.00556	93	0.00833	1.40512	143.833	0.16214	0.20425
PTS-Fru-EIIC, fruA; PTS system, fructose-specific IIC component	0.04204	0.00416	0.04892	0.00249	0.00619	65	0.03722	0.00288	0.00556	93	0.00833	1.40512	143.833	0.16214	0.20425
rpoD; RNA polymerase primary sigma factor	0.04204	0.00416	0.04892	0.00249	0.00619	65	0.03722	0.00288	0.00556	93	0.00833	1.40512	143.833	0.16214	0.20425
thiH; 2-iminoacetate synthase [EC:4.1.99.19]	0.04204	0.00416	0.04892	0.00249	0.00619	65	0.03722	0.00288	0.00556	93	0.00833	1.40512	143.833	0.16214	0.20425
trxA; thioredoxin 1	0.04204	0.00416	0.04892	0.00249	0.00619	65	0.03722	0.00288	0.00556	93	0.00833	1.40512	143.833	0.16214	0.20425
arsA, ASNA1, GET3; arsenite/tail-anchored protein-transporting ATPase [EC:3.6.3.16 3.6.3.-]	0.04085	0.00536	0.05132	0.00517	0.00892	65	0.03354	0.00403	0.00658	93	0.01109	1.60410	126.567	0.11118	0.14417
ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]	0.04085	0.00536	0.05132	0.00517	0.00892	65	0.03354	0.00403	0.00658	93	0.01109	1.60410	126.567	0.11118	0.14417
K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	0.04085	0.00536	0.05132	0.00517	0.00892	65	0.03354	0.00403	0.00658	93	0.01109	1.60410	126.567	0.11118	0.14417
glk; glucokinase [EC:2.7.1.2]	0.04073	0.00397	0.04881	0.00248	0.00618	65	0.03509	0.00244	0.00512	93	0.00803	1.70932	137.089	0.08965	0.12309
K07001; NTE family protein	0.04073	0.00397	0.04881	0.00248	0.00618	65	0.03509	0.00244	0.00512	93	0.00803	1.70932	137.089	0.08965	0.12309
K07095; uncharacterized protein	0.04073	0.00397	0.04881	0.00248	0.00618	65	0.03509	0.00244	0.00512	93	0.00803	1.70932	137.089	0.08965	0.12309
mscS; small conductance mechanosensitive channel	0.04073	0.00397	0.04881	0.00248	0.00618	65	0.03509	0.00244	0.00512	93	0.00803	1.70932	137.089	0.08965	0.12309
murF; UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase [EC:6.3.2.10]	0.04073	0.00397	0.04881	0.00248	0.00618	65	0.03509	0.00244	0.00512	93	0.00803	1.70932	137.089	0.08965	0.12309
PTS-EI.PTSI, ptsI; phosphotransferase system, enzyme I, PtsI [EC:2.7.3.9]	0.04073	0.00397	0.04881	0.00248	0.00618	65	0.03509	0.00244	0.00512	93	0.00803	1.70932	137.089	0.08965	0.12309
pyrF; orotidine-5’-phosphate decarboxylase [EC:4.1.1.23]	0.04073	0.00397	0.04881	0.00248	0.00618	65	0.03509	0.00244	0.00512	93	0.00803	1.70932	137.089	0.08965	0.12309
rfbD, rmlD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]	0.04073	0.00397	0.04881	0.00248	0.00618	65	0.03509	0.00244	0.00512	93	0.00803	1.70932	137.089	0.08965	0.12309
TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family	0.04073	0.00397	0.04881	0.00248	0.00618	65	0.03509	0.00244	0.00512	93	0.00803	1.70932	137.089	0.08965	0.12309
trmB, METTL1; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]	0.04073	0.00397	0.04881	0.00248	0.00618	65	0.03509	0.00244	0.00512	93	0.00803	1.70932	137.089	0.08965	0.12309
yfbK; Ca-activated chloride channel homolog	0.03943	0.00395	0.04870	0.00248	0.00617	65	0.03295	0.00238	0.00505	93	0.00798	1.97377	136.042	0.05043	0.08455
ATPVD, ntpD, atpD; V/A-type H+/Na+-transporting ATPase subunit D	0.03926	0.00419	0.04887	0.00301	0.00681	65	0.03254	0.00252	0.00521	93	0.00857	1.90592	129.854	0.05887	0.08557
eutN; ethanolamine utilization protein EutN	0.03795	0.00417	0.04876	0.00301	0.00680	65	0.03040	0.00245	0.00513	93	0.00852	2.15572	128.590	0.03297	0.08455
MMAB, pduO; cob(I)alamin adenosyltransferase [EC:2.5.1.17]	0.03795	0.00417	0.04876	0.00301	0.00680	65	0.03040	0.00245	0.00513	93	0.00852	2.15572	128.590	0.03297	0.08455
TC.OOP; OmpA-OmpF porin, OOP family	0.03795	0.00417	0.04876	0.00301	0.00680	65	0.03040	0.00245	0.00513	93	0.00852	2.15572	128.590	0.03297	0.08455
K07088; uncharacterized protein	0.03692	0.00352	0.04318	0.00173	0.00516	65	0.03254	0.00208	0.00473	93	0.00700	1.51988	145.462	0.13071	0.16878
tuf, TUFM; elongation factor Tu	0.03692	0.00352	0.04318	0.00173	0.00516	65	0.03254	0.00208	0.00473	93	0.00700	1.51988	145.462	0.13071	0.16878
ABC.SS.A; simple sugar transport system ATP-binding protein [EC:3.6.3.17]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ABCF3; ATP-binding cassette, subfamily F, member 3	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ackA; acetate kinase [EC:2.7.2.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
acpP; acyl carrier protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
adk, AK; adenylate kinase [EC:2.7.4.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
apbE; FAD:protein FMN transferase [EC:2.7.1.180]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
APEH; acylaminoacyl-peptidase [EC:3.4.19.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
AROA2, aroA; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
aroC; chorismate synthase [EC:4.2.3.5]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ARSC1, arsC; arsenate reductase [EC:1.20.4.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
asnA; aspartate–ammonia ligase [EC:6.3.1.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
aspB; aspartate aminotransferase [EC:2.6.1.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
aspS; aspartyl-tRNA synthetase [EC:6.1.1.12]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
atoE; short-chain fatty acids transporter	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ATPF0A, atpB; F-type H+-transporting ATPase subunit a	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ATPF0B, atpF; F-type H+-transporting ATPase subunit b	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ATPF0C, atpE; F-type H+-transporting ATPase subunit c	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ATPF1A, atpA; F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ATPF1B, atpD; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ATPF1D, atpH; F-type H+-transporting ATPase subunit delta	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ATPF1E, atpC; F-type H+-transporting ATPase subunit epsilon	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ATPF1G, atpG; F-type H+-transporting ATPase subunit gamma	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
bax; Bax protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
bioA; adenosylmethionine—8-amino-7-oxononanoate aminotransferase [EC:2.6.1.62]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
bioC; malonyl-CoA O-methyltransferase [EC:2.1.1.197]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
bioD; dethiobiotin synthetase [EC:6.3.3.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
bioG; pimeloyl-[acyl-carrier protein] methyl ester esterase [EC:3.1.1.85]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
birA; BirA family transcriptional regulator, biotin operon repressor / biotin—[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
CARP, pepA; leucyl aminopeptidase [EC:3.4.11.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cas1; CRISP-associated protein Cas1	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cas2; CRISPR-associated protein Cas2	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cat2, abfT; 4-hydroxybutyrate CoA-transferase [EC:2.8.3.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cbiB, cobD; adenosylcobinamide-phosphate synthase [EC:6.3.1.10]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cbiD; cobalt-precorrin-5B (C1)-methyltransferase [EC:2.1.1.195]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cbiE; cobalt-precorrin-7 (C5)-methyltransferase [EC:2.1.1.289]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cbiG; cobalt-precorrin 5A hydrolase [EC:3.7.1.12]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cbiK; sirohydrochlorin cobaltochelatase [EC:4.99.1.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cbiT; cobalt-precorrin-6B (C15)-methyltransferase [EC:2.1.1.196]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
CHO1, pssA; CDP-diacylglycerol—serine O-phosphatidyltransferase [EC:2.7.8.8]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cidA; holin-like protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
citD; citrate lyase subunit gamma (acyl carrier protein)	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
clpB; ATP-dependent Clp protease ATP-binding subunit ClpB	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
clpX, CLPX; ATP-dependent Clp protease ATP-binding subunit ClpX	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
clsA_B; cardiolipin synthase A/B [EC:2.7.8.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cmk; CMP/dCMP kinase [EC:2.7.4.25]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
coaBC, dfp; phosphopantothenoylcysteine decarboxylase / phosphopantothenate—cysteine ligase [EC:4.1.1.36 6.3.2.5]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
coaE; dephospho-CoA kinase [EC:2.7.1.24]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
coaX; type III pantothenate kinase [EC:2.7.1.33]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cobA-hemD; uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cobA, btuR; cob(I)alamin adenosyltransferase [EC:2.5.1.17]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cobB-cbiA; cobyrinic acid a,c-diamide synthase [EC:6.3.5.9 6.3.5.11]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cobC, phpB; alpha-ribazole phosphatase [EC:3.1.3.73]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cobD; threonine-phosphate decarboxylase [EC:4.1.1.81]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cobH-cbiC; precorrin-8X/cobalt-precorrin-8 methylmutase [EC:5.4.99.61 5.4.99.60]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cobI-cbiL; precorrin-2/cobalt-factor-2 C20-methyltransferase [EC:2.1.1.130 2.1.1.151]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cobK-cbiJ; precorrin-6A/cobalt-precorrin-6A reductase [EC:1.3.1.54 1.3.1.106]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cobM, cbiF; precorrin-4/cobalt-precorrin-4 C11-methyltransferase [EC:2.1.1.133 2.1.1.271]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cobP, cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
comEA; competence protein ComEA	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
comEB; dCMP deaminase [EC:3.5.4.12]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
comEC; competence protein ComEC	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
comFC; competence protein ComFC	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
comM; magnesium chelatase family protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
copA, ATP7; Cu+-exporting ATPase [EC:3.6.3.54]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
corA; magnesium transporter	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
creD; inner membrane protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
crt; enoyl-CoA hydratase [EC:4.2.1.17]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cutC; copper homeostasis protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cvpA; membrane protein required for colicin V production	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
cvrA, nhaP2; cell volume regulation protein A	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
dacC, dacA, dacD; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
deaD, cshA; ATP-dependent RNA helicase DeaD [EC:3.6.4.13]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
deoD; purine-nucleoside phosphorylase [EC:2.4.2.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
DHFR, folA; dihydrofolate reductase [EC:1.5.1.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
dinG; ATP-dependent DNA helicase DinG [EC:3.6.4.12]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
disA; diadenylate cyclase [EC:2.7.7.85]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
dnaB; replicative DNA helicase [EC:3.6.4.12]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
dnaG; DNA primase [EC:2.7.7.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
dnaJ; molecular chaperone DnaJ	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
dnaK, HSPA9; molecular chaperone DnaK	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
dpo; DNA polymerase bacteriophage-type [EC:2.7.7.7]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
dps; starvation-inducible DNA-binding protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
dtd, DTD1; D-tyrosyl-tRNA(Tyr) deacylase [EC:3.1.-.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
dxr; 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E2.1.1.104; caffeoyl-CoA O-methyltransferase [EC:2.1.1.104]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E2.1.1.131, cobJ, cbiH; precorrin-3B C17-methyltransferase [EC:2.1.1.131]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E2.3.1.54, pflD; formate C-acetyltransferase [EC:2.3.1.54]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E2.3.1.8, pta; phosphate acetyltransferase [EC:2.3.1.8]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E2.3.1.9, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E2.4.2.21, cobU, cobT; nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E2.7.1.71, aroK, aroL; shikimate kinase [EC:2.7.1.71]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E2.7.4.8, gmk; guanylate kinase [EC:2.7.4.8]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E2.7.7.3A, coaD, kdtB; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E3.1.3.15B; histidinol-phosphatase (PHP family) [EC:3.1.3.15]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E3.4.11.-; aminopeptidase [EC:3.4.11.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E3.4.17.19; carboxypeptidase Taq [EC:3.4.17.19]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E3.4.21.102, prc, ctpA; carboxyl-terminal processing protease [EC:3.4.21.102]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E3.6.3.8; Ca2+-transporting ATPase [EC:3.6.3.8]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E4.1.3.3, nanA, NPL; N-acetylneuraminate lyase [EC:4.1.3.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E4.3.1.17, sdaA, sdaB, tdcG; L-serine dehydratase [EC:4.3.1.17]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E4.4.1.11; methionine-gamma-lyase [EC:4.4.1.11]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ecfT; energy-coupling factor transport system permease protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
efp; elongation factor P	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
engA, der; GTPase	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
engB; GTP-binding protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ENO, eno; enolase [EC:4.2.1.11]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
era, ERAL1; GTPase	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
fadL; long-chain fatty acid transport protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
fbp3; fructose-1,6-bisphosphatase III [EC:3.1.3.11]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
fhs; formate–tetrahydrofolate ligase [EC:6.3.4.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
fnr; CRP/FNR family transcriptional regulator, anaerobic regulatory protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
folP; dihydropteroate synthase [EC:2.5.1.15]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
frr, MRRF, RRF; ribosome recycling factor	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
fruK; 1-phosphofructokinase [EC:2.7.1.56]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
fruR2, fruR; DeoR family transcriptional regulator, fructose operon transcriptional repressor	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ftsA; cell division protein FtsA	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ftsH, hflB; cell division protease FtsH [EC:3.4.24.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ftsQ; cell division protein FtsQ	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ftsW, spoVE; cell division protein FtsW	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ftsX; cell division transport system permease protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ftsY; fused signal recognition particle receptor	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ftsZ; cell division protein FtsZ	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
fur, zur, furB; Fur family transcriptional regulator, ferric uptake regulator	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
galK; galactokinase [EC:2.7.1.6]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
galM, GALM; aldose 1-epimerase [EC:5.1.3.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
galT, GALT; UDPglucose–hexose-1-phosphate uridylyltransferase [EC:2.7.7.12]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gatA, QRSL1; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gatB, PET112; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gatC, GATC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
GBE1, glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gcdA; glutaconyl-CoA decarboxylase [EC:4.1.1.70]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gcpE, ispG; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gctA; glutaconate CoA-transferase, subunit A [EC:2.8.3.12]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gctB; glutaconate CoA-transferase, subunit B [EC:2.8.3.12]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
glgA; starch synthase [EC:2.4.1.21]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
glgX; glycogen debranching enzyme [EC:3.2.1.196]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
glmM; phosphoglucosamine mutase [EC:5.4.2.10]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
glmS, GFPT; glucosamine—fructose-6-phosphate aminotransferase (isomerizing) [EC:2.6.1.16]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
glmS, mutS, mamA; methylaspartate mutase sigma subunit [EC:5.4.99.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
glnG, ntrC; two-component system, NtrC family, nitrogen regulation response regulator GlnG	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gloB, HAGH; hydroxyacylglutathione hydrolase [EC:3.1.2.6]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
GLPF; glycerol uptake facilitator protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
glpK, GK; glycerol kinase [EC:2.7.1.30]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
glpP; glycerol uptake operon antiterminator	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
glpX; fructose-1,6-bisphosphatase II [EC:3.1.3.11]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
glsA, GLS; glutaminase [EC:3.5.1.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gmhA, lpcA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gmhD, rfaD; ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
GPI, pgi; glucose-6-phosphate isomerase [EC:5.3.1.9]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gpmB; probable phosphoglycerate mutase [EC:5.4.2.12]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gpx; glutathione peroxidase [EC:1.11.1.9]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
groEL, HSPD1; chaperonin GroEL	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
groES, HSPE1; chaperonin GroES	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
GRPE; molecular chaperone GrpE	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gspD; general secretion pathway protein D	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gspG; general secretion pathway protein G	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gudB, rocG; glutamate dehydrogenase [EC:1.4.1.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gyrA; DNA gyrase subunit A [EC:5.99.1.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
gyrB; DNA gyrase subunit B [EC:5.99.1.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
hcp; hydroxylamine reductase [EC:1.7.99.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
hemA; glutamyl-tRNA reductase [EC:1.2.1.70]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
hemC, HMBS; hydroxymethylbilane synthase [EC:2.5.1.61]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
hemK, prmC, HEMK; release factor glutamine methyltransferase [EC:2.1.1.297]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
hemL; glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
hflX; GTPase	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
HINT1, hinT, hit; histidine triad (HIT) family protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
hlpA, ompH; outer membrane protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
hlyIII; hemolysin III	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
holA; DNA polymerase III subunit delta [EC:2.7.7.7]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
holB; DNA polymerase III subunit delta’ [EC:2.7.7.7]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
hppA; K(+)-stimulated pyrophosphate-energized sodium pump [EC:3.6.1.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
hprK, ptsK; HPr kinase/phosphorylase [EC:2.7.11.- 2.7.4.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
hrcA; heat-inducible transcriptional repressor	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
hslO; molecular chaperone Hsp33	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
HSP90A, htpG; molecular chaperone HtpG	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
htpX; heat shock protein HtpX [EC:3.4.24.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
hutG; formiminoglutamase [EC:3.5.3.8]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
infA; translation initiation factor IF-1	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
infB, MTIF2; translation initiation factor IF-2	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
infC, MTIF3; translation initiation factor IF-3	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
iscU, nifU; nitrogen fixation protein NifU and related proteins	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ispH, lytB; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
jag; spoIIIJ-associated protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K00243; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K01163; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K02477; two-component system, LytTR family, response regulator	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K03653; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K06890; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K06894; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K06960; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K06975; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K07030; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K07035; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K07037; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K07043; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K07058; membrane protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K07069; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K07082; UPF0755 protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K07105; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K07120; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K07124; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K07139; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K07461; putative endonuclease	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K08884; serine/threonine protein kinase, bacterial [EC:2.7.11.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K08974; putative membrane protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K08998; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K09125; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K09729; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K09747; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K09762; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K09769; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K09778; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K09787; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K09790; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K09802; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K09861; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K09949; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
K11145; ribonuclease III family protein [EC:3.1.26.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
kal; 3-aminobutyryl-CoA ammonia-lyase [EC:4.3.1.14]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
kamA; lysine 2,3-aminomutase [EC:5.4.3.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
kamD; beta-lysine 5,6-aminomutase alpha subunit [EC:5.4.3.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
kamE; beta-lysine 5,6-aminomutase beta subunit [EC:5.4.3.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
kce; 3-keto-5-aminohexanoate cleavage enzyme [EC:2.3.1.247]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
kdd; L-erythro-3,5-diaminohexanoate dehydrogenase [EC:1.4.1.11]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
kdsD, kpsF; arabinose-5-phosphate isomerase [EC:5.3.1.13]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
LDH, ldh; L-lactate dehydrogenase [EC:1.1.1.27]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
lemA; LemA protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
lepA; GTP-binding protein LepA	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
lepB; signal peptidase I [EC:3.4.21.89]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
lgt, umpA; phosphatidylglycerol:prolipoprotein diacylglycerol transferase [EC:2.-.-.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
livF; branched-chain amino acid transport system ATP-binding protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
livG; branched-chain amino acid transport system ATP-binding protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
livH; branched-chain amino acid transport system permease protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
livK; branched-chain amino acid transport system substrate-binding protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
livM; branched-chain amino acid transport system permease protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
lolC_E; lipoprotein-releasing system permease protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
lolD; lipoprotein-releasing system ATP-binding protein [EC:3.6.3.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
lptB; lipopolysaccharide export system ATP-binding protein [EC:3.6.3.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
lptF; lipopolysaccharide export system permease protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
lptG; lipopolysaccharide export system permease protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
lpxC; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [EC:3.5.1.108]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
lpxK; tetraacyldisaccharide 4’-kinase [EC:2.7.1.130]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
lspA; signal peptidase II [EC:3.4.23.36]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ltaE; threonine aldolase [EC:4.1.2.48]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
lysE, argO; L-lysine exporter family protein LysE/ArgO	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
maf; septum formation protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
malQ; 4-alpha-glucanotransferase [EC:2.4.1.25]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
map; methionyl aminopeptidase [EC:3.4.11.18]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
MET8; precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:1.3.1.76 4.99.1.4]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
metH, MTR; 5-methyltetrahydrofolate–homocysteine methyltransferase [EC:2.1.1.13]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
metI; D-methionine transport system permease protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
metK; S-adenosylmethionine synthetase [EC:2.5.1.6]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
metN; D-methionine transport system ATP-binding protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mfd; transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mglA; methyl-galactoside transport system ATP-binding protein [EC:3.6.3.17]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mglB; methyl-galactoside transport system substrate-binding protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mglC; methyl-galactoside transport system permease protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mgtC; putative Mg2+ transporter-C (MgtC) family protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mgtE; magnesium transporter	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
minC; septum site-determining protein MinC	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
minD; septum site-determining protein MinD	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
minE; cell division topological specificity factor	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mipA, ompV; MipA family protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mlaA, vacJ; phospholipid-binding lipoprotein MlaA	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mraW, rsmH; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mrcA; penicillin-binding protein 1A [EC:2.4.1.129 3.4.16.4]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mrdA; penicillin-binding protein 2 [EC:3.4.16.4]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mreC; rod shape-determining protein MreC	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:3.6.3.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mscL; large conductance mechanosensitive channel	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mtnN, mtn, pfs; adenosylhomocysteine nucleosidase [EC:3.2.2.9]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
murC; UDP-N-acetylmuramate–alanine ligase [EC:6.3.2.8]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
murD; UDP-N-acetylmuramoylalanine–D-glutamate ligase [EC:6.3.2.9]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase [EC:6.3.2.13]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
murG; UDP-N-acetylglucosamine–N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mutL; DNA mismatch repair protein MutL	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mutS; DNA mismatch repair protein MutS	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
mutS2; DNA mismatch repair protein MutS2	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
nadA; quinolinate synthase [EC:2.5.1.72]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
nadB; L-aspartate oxidase [EC:1.4.3.16]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
nadE; NAD+ synthase [EC:6.3.1.5]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
nagA, AMDHD2; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
nanE; N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
nrdR; transcriptional repressor NrdR	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
nusA; N utilization substance protein A	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
nusB; N utilization substance protein B	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
nusG; transcriptional antiterminator NusG	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
oadA; oxaloacetate decarboxylase, alpha subunit [EC:4.1.1.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
oadB; oxaloacetate decarboxylase, beta subunit [EC:4.1.1.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
obgE, cgtA; GTPase [EC:3.6.5.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ogt, MGMT; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
oppD; oligopeptide transport system ATP-binding protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
opuA; osmoprotectant transport system ATP-binding protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
opuBD; osmoprotectant transport system permease protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
paaH, hbd, fadB, mmgB; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
panF; sodium/pantothenate symporter	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pbpC; penicillin-binding protein 1C [EC:2.4.1.129]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pcp; pyroglutamyl-peptidase [EC:3.4.19.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
PDF, def; peptide deformylase [EC:3.5.1.88]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pdxS, pdx1; pyridoxal 5’-phosphate synthase pdxS subunit [EC:4.3.3.6]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pepF, pepB; oligoendopeptidase F [EC:3.4.24.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pepQ; Xaa-Pro dipeptidase [EC:3.4.13.9]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pepT; tripeptide aminopeptidase [EC:3.4.11.4]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
perR; Fur family transcriptional regulator, peroxide stress response regulator	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pflA, pflC, pflE; pyruvate formate lyase activating enzyme [EC:1.97.1.4]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pgm; phosphoglucomutase [EC:5.4.2.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pgpA; phosphatidylglycerophosphatase A [EC:3.1.3.27]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pheB; chorismate mutase [EC:5.4.99.5]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pilB; type IV pilus assembly protein PilB	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pilC; type IV pilus assembly protein PilC	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pilD, pppA; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pilT; twitching motility protein PilT	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
PK, pyk; pyruvate kinase [EC:2.7.1.40]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
plsX; glycerol-3-phosphate acyltransferase PlsX [EC:2.3.1.15]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
plsY; glycerol-3-phosphate acyltransferase PlsY [EC:2.3.1.15]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pncB, NAPRT1; nicotinate phosphoribosyltransferase [EC:6.3.4.21]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
polA; DNA polymerase I [EC:2.7.7.7]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
potA; spermidine/putrescine transport system ATP-binding protein [EC:3.6.3.31]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
potB; spermidine/putrescine transport system permease protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
potC; spermidine/putrescine transport system permease protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
potD; spermidine/putrescine transport system substrate-binding protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ppaC; manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
PPIB, ppiB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ppnK, NADK; NAD+ kinase [EC:2.7.1.23]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ppx-gppA; exopolyphosphatase / guanosine-5’-triphosphate,3’-diphosphate pyrophosphatase [EC:3.6.1.11 3.6.1.40]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
PRDX2_4, ahpC; peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC:1.11.1.15]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
prfA, MTRF1, MRF1; peptide chain release factor 1	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
prfB; peptide chain release factor 2	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
priA; primosomal protein N’ (replication factor Y) (superfamily II helicase) [EC:3.6.4.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
PTH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
PTS-Fru-EIIA, fruB; PTS system, fructose-specific IIA component [EC:2.7.1.202]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
PTS-Glc-EIIA, crr; PTS system, sugar-specific IIA component [EC:2.7.1.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
PTS-HPR.PTSH, ptsH; phosphocarrier protein HPr	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
PTS-HPR; phosphocarrier protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
PTS-Nag-EIIC, nagE; PTS system, N-acetylglucosamine-specific IIC component	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
purB, ADSL; adenylosuccinate lyase [EC:4.3.2.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
purD; phosphoribosylamine—glycine ligase [EC:6.3.4.13]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
purL, PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
putP; sodium/proline symporter	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pyrB, PYR2; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pyrDII; dihydroorotate dehydrogenase electron transfer subunit	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pyrH; uridylate kinase [EC:2.7.4.22]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
pyrP, uraA; uracil permease	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
queH; epoxyqueuosine reductase [EC:1.17.99.6]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
radA, sms; DNA repair protein RadA/Sms	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
radC; DNA repair protein RadC	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rapZ; RNase adapter protein RapZ	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rbfA; ribosome-binding factor A	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rbgA; ribosome biogenesis GTPase A	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
recA; recombination protein RecA	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
recF; DNA replication and repair protein RecF	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
recN; DNA repair protein RecN (Recombination protein N)	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
recQ; ATP-dependent DNA helicase RecQ [EC:3.6.4.12]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
recR; recombination protein RecR	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
recX; regulatory protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rho; transcription termination factor Rho	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ribH, RIB4; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ridA, tdcF, RIDA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rimI; [ribosomal protein S18]-alanine N-acetyltransferase [EC:2.3.1.266]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rimM; 16S rRNA processing protein RimM	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rimP; ribosome maturation factor RimP	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rlmB; 23S rRNA (guanosine2251-2’-O)-methyltransferase [EC:2.1.1.185]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rluC; 23S rRNA pseudouridine955/2504/2580 synthase [EC:5.4.99.24]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rnfA; electron transport complex protein RnfA	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rnfC; electron transport complex protein RnfC	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rnfD; electron transport complex protein RnfD	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rnfE; electron transport complex protein RnfE	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rnfG; electron transport complex protein RnfG	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rng, cafA; ribonuclease G [EC:3.1.26.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rnhB; ribonuclease HII [EC:3.1.26.4]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rnmV; ribonuclease M5 [EC:3.1.26.8]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rnpA; ribonuclease P protein component [EC:3.1.26.5]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rnr, vacB; ribonuclease R [EC:3.1.-.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rny; ribonucrease Y [EC:3.1.-.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rodA, mrdB; rod shape determining protein RodA	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L1, MRPL1, rplA; large subunit ribosomal protein L1	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L10, MRPL10, rplJ; large subunit ribosomal protein L10	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L11, MRPL11, rplK; large subunit ribosomal protein L11	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L13, MRPL13, rplM; large subunit ribosomal protein L13	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L14, MRPL14, rplN; large subunit ribosomal protein L14	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L15, MRPL15, rplO; large subunit ribosomal protein L15	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L16, MRPL16, rplP; large subunit ribosomal protein L16	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L17, MRPL17, rplQ; large subunit ribosomal protein L17	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L18, MRPL18, rplR; large subunit ribosomal protein L18	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L19, MRPL19, rplS; large subunit ribosomal protein L19	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L2, MRPL2, rplB; large subunit ribosomal protein L2	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L20, MRPL20, rplT; large subunit ribosomal protein L20	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L21, MRPL21, rplU; large subunit ribosomal protein L21	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L22, MRPL22, rplV; large subunit ribosomal protein L22	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L23, MRPL23, rplW; large subunit ribosomal protein L23	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L24, MRPL24, rplX; large subunit ribosomal protein L24	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L27, MRPL27, rpmA; large subunit ribosomal protein L27	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L28, MRPL28, rpmB; large subunit ribosomal protein L28	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L29, rpmC; large subunit ribosomal protein L29	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L30, MRPL30, rpmD; large subunit ribosomal protein L30	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L31, rpmE; large subunit ribosomal protein L31	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L32, MRPL32, rpmF; large subunit ribosomal protein L32	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L33, MRPL33, rpmG; large subunit ribosomal protein L33	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L34, MRPL34, rpmH; large subunit ribosomal protein L34	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L35, MRPL35, rpmI; large subunit ribosomal protein L35	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L36, MRPL36, rpmJ; large subunit ribosomal protein L36	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L4, MRPL4, rplD; large subunit ribosomal protein L4	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L5, MRPL5, rplE; large subunit ribosomal protein L5	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L6, MRPL6, rplF; large subunit ribosomal protein L6	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L7, MRPL12, rplL; large subunit ribosomal protein L7/L12	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-L9, MRPL9, rplI; large subunit ribosomal protein L9	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S10, MRPS10, rpsJ; small subunit ribosomal protein S10	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S11, MRPS11, rpsK; small subunit ribosomal protein S11	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S13, rpsM; small subunit ribosomal protein S13	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S14, MRPS14, rpsN; small subunit ribosomal protein S14	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S15, MRPS15, rpsO; small subunit ribosomal protein S15	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S16, MRPS16, rpsP; small subunit ribosomal protein S16	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S17, MRPS17, rpsQ; small subunit ribosomal protein S17	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S19, rpsS; small subunit ribosomal protein S19	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S20, rpsT; small subunit ribosomal protein S20	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S3, rpsC; small subunit ribosomal protein S3	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S4, rpsD; small subunit ribosomal protein S4	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S5, MRPS5, rpsE; small subunit ribosomal protein S5	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S7, MRPS7, rpsG; small subunit ribosomal protein S7	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S8, rpsH; small subunit ribosomal protein S8	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
RP-S9, MRPS9, rpsI; small subunit ribosomal protein S9	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rpe, RPE; ribulose-phosphate 3-epimerase [EC:5.1.3.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rpoC; DNA-directed RNA polymerase subunit beta’ [EC:2.7.7.6]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rpoE; RNA polymerase sigma-70 factor, ECF subfamily	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rsbU_P; phosphoserine phosphatase RsbU/P [EC:3.1.3.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rsbV; anti-sigma B factor antagonist	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rsbW; serine/threonine-protein kinase RsbW [EC:2.7.11.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rseC; sigma-E factor negative regulatory protein RseC	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rseP; regulator of sigma E protease [EC:3.4.24.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rsmB, sun; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rsmC; 16S rRNA (guanine1207-N2)-methyltransferase [EC:2.1.1.172]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rsmI; 16S rRNA (cytidine1402-2’-O)-methyltransferase [EC:2.1.1.198]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rtpR; ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ruvA; holliday junction DNA helicase RuvA [EC:3.6.4.12]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ruvB; holliday junction DNA helicase RuvB [EC:3.6.4.12]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ruvX; putative holliday junction resolvase [EC:3.1.-.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
SAM50, TOB55, bamA; outer membrane protein insertion porin family	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
sbcC, rad50; DNA repair protein SbcC/Rad50	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
scpA; segregation and condensation protein A	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
scpB; segregation and condensation protein B	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
secA; preprotein translocase subunit SecA	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
secD; preprotein translocase subunit SecD	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
secE; preprotein translocase subunit SecE	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
secF; preprotein translocase subunit SecF	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
secG; preprotein translocase subunit SecG	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
secY; preprotein translocase subunit SecY	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
slyD; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
smc; chromosome segregation protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
smpB; SsrA-binding protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
splB; spore photoproduct lyase [EC:4.1.99.14]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
spoIID; stage II sporulation protein D	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
spoT; GTP diphosphokinase / guanosine-3’,5’-bis(diphosphate) 3’-diphosphatase [EC:2.7.6.5 3.1.7.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
spoU; RNA methyltransferase, TrmH family	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
spoVG; stage V sporulation protein G	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ssb; single-strand DNA-binding protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
sulD; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:4.1.2.25 2.7.6.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
tagD; glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
tatD; TatD DNase family protein [EC:3.1.21.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
TC.GPH; glycoside/pentoside/hexuronide:cation symporter, GPH family	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
TC.OMF; outer membrane factor, OMF family	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
tctA; putative tricarboxylic transport membrane protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
tex; protein Tex	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
tgt, QTRT1; queuine tRNA-ribosyltransferase [EC:2.4.2.29]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
thiF; sulfur carrier protein ThiS adenylyltransferase [EC:2.7.7.73]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
thiG; thiazole synthase [EC:2.8.1.10]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
thiS; sulfur carrier protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
thyA, TYMS; thymidylate synthase [EC:2.1.1.45]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
tig; trigger factor	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
tlyA; 23S rRNA (cytidine1920-2’-O)/16S rRNA (cytidine1409-2’-O)-methyltransferase [EC:2.1.1.226 2.1.1.227]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
tlyC; putative hemolysin	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
tmk, DTYMK; dTMP kinase [EC:2.7.4.9]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
topA; DNA topoisomerase I [EC:5.99.1.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
TPI, tpiA; triosephosphate isomerase (TIM) [EC:5.3.1.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
trmFO, gid; methylenetetrahydrofolate–tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
trmL, cspR; tRNA (cytidine/uridine-2’-O-)-methyltransferase [EC:2.1.1.207]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
truA, PUS1; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
truB, PUS4, TRUB1; tRNA pseudouridine55 synthase [EC:5.4.99.25]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
tsaC, rimN, SUA5; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
tsf, TSFM; elongation factor Ts	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
typA, bipA; GTP-binding protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
tyrB; aromatic-amino-acid transaminase [EC:2.6.1.57]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
UGP2, galU, galF; UTP–glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
URA4, pyrC; dihydroorotase [EC:3.5.2.3]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
uvrA; excinuclease ABC subunit A	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
uvrB; excinuclease ABC subunit B	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
uvrC; excinuclease ABC subunit C	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
yajC; preprotein translocase subunit YajC	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ybaK, ebsC; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ybcJ; ribosome-associated protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ybeY, yqfG; probable rRNA maturation factor	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ybjD; putative ATP-dependent endonuclease of the OLD family	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ycaJ; putative ATPase	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ychF; ribosome-binding ATPase	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
yesN; two-component system, response regulator YesN	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
yfiH; polyphenol oxidase [EC:1.10.3.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
yggS, PROSC; PLP dependent protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
yggT; YggT family protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
yhbH; putative sigma-54 modulation protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
yhbY; RNA-binding protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
yjbB; phosphate:Na+ symporter	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ylxR; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
yqeH; 30S ribosome assembly GTPase	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
yraN; putative endonuclease	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
ysxB; uncharacterized protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
zntA; Cd2+/Zn2+-exporting ATPase [EC:3.6.3.3 3.6.3.5]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
znuB; zinc transport system permease protein	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
znuC; zinc transport system ATP-binding protein [EC:3.6.3.-]	0.03561	0.00327	0.04307	0.00172	0.00514	65	0.03040	0.00162	0.00418	93	0.00663	1.91114	135.408	0.05810	0.08455
citC; [citrate (pro-3S)-lyase] ligase [EC:6.2.1.22]	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
ctpC; manganese/zinc-transporting P-type ATPase C [EC:3.6.3.-]	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
E2.7.1.37; protein kinase [EC:2.7.1.37]	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
E3.5.1.28D, amiD; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
E4.1.1.17, ODC1, speC, speF; ornithine decarboxylase [EC:4.1.1.17]	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
frdA; fumarate reductase flavoprotein subunit [EC:1.3.5.4]	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
glmE, mutE, mamB; methylaspartate mutase epsilon subunit [EC:5.4.99.1]	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
gspF; general secretion pathway protein F	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
hprA; glycerate dehydrogenase [EC:1.1.1.29]	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
K02481; two-component system, NtrC family, response regulator	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
K07085; putative transport protein	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
motB; chemotaxis protein MotB	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
pabC; 4-amino-4-deoxychorismate lyase [EC:4.1.3.38]	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
penP; beta-lactamase class A [EC:3.5.2.6]	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
thrB2; homoserine kinase type II [EC:2.7.1.39]	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]	0.03431	0.00323	0.04295	0.00171	0.00513	65	0.02827	0.00154	0.00407	93	0.00655	2.24311	133.246	0.02654	0.08455
dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]	0.03197	0.00370	0.03726	0.00217	0.00578	65	0.02827	0.00215	0.00481	93	0.00752	1.19496	137.414	0.23416	0.27430
K07496; putative transposase	0.03141	0.00561	0.04039	0.00614	0.00972	65	0.02513	0.00413	0.00666	93	0.01178	1.29564	119.916	0.19759	0.24814
ATPVA, ntpA, atpA; V/A-type H+/Na+-transporting ATPase subunit A [EC:3.6.3.14 3.6.3.15]	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
ATPVB, ntpB, atpB; V/A-type H+/Na+-transporting ATPase subunit B	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
ATPVC, ntpC, atpC; V/A-type H+/Na+-transporting ATPase subunit C	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
ATPVE, ntpE, atpE; V/A-type H+/Na+-transporting ATPase subunit E	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
ATPVF, ntpF, atpF; V/A-type H+/Na+-transporting ATPase subunit F	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
ATPVI, ntpI, atpI; V/A-type H+/Na+-transporting ATPase subunit I	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
ATPVK, ntpK, atpK; V/A-type H+/Na+-transporting ATPase subunit K	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
dhaK; phosphoenolpyruvate—glycerone phosphotransferase subunit DhaK [EC:2.7.1.121]	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
dhaL; phosphoenolpyruvate—glycerone phosphotransferase subunit DhaL [EC:2.7.1.121]	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
E4.1.99.2; tyrosine phenol-lyase [EC:4.1.99.2]	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
eutH; ethanolamine transporter	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
gspE; general secretion pathway protein E	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
K06885; uncharacterized protein	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
K06889; uncharacterized protein	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
K07006; uncharacterized protein	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
K07160; UPF0271 protein	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
nagD; NagD protein	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
serA, PHGDH; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
tctB; putative tricarboxylic transport membrane protein	0.03050	0.00306	0.03732	0.00152	0.00484	65	0.02572	0.00141	0.00389	93	0.00621	1.86779	134.370	0.06397	0.09054
ABC.ZM.S; zinc/manganese transport system substrate-binding protein	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
atpI; ATP synthase protein I	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
ATPVG, ahaH, atpH; V/A-type H+/Na+-transporting ATPase subunit G/H	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
bioY; biotin transport system substrate-specific component	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
citG; triphosphoribosyl-dephospho-CoA synthase [EC:2.4.2.52]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
citX; holo-ACP synthase [EC:2.7.7.61]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
CNP; 2’,3’-cyclic-nucleotide 3’-phosphodiesterase [EC:3.1.4.37]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
dam; DNA adenine methylase [EC:2.1.1.72]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
E3.1.3.41; 4-nitrophenyl phosphatase [EC:3.1.3.41]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
E4.1.1.49, pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
ecfA1; energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
eutA; ethanolamine utilization protein EutA	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
eutB; ethanolamine ammonia-lyase large subunit [EC:4.3.1.7]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
eutC; ethanolamine ammonia-lyase small subunit [EC:4.3.1.7]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
eutJ; ethanolamine utilization protein EutJ	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
eutL; ethanolamine utilization protein EutL	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
eutM; ethanolamine utilization protein EutM	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
eutP; ethanolamine utilization protein EutP	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
eutQ; ethanolamine utilization protein EutQ	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
eutS; ethanolamine utilization protein EutS	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
eutT; ethanolamine utilization cobalamin adenosyltransferase [EC:2.5.1.17]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
FTR, FTH1, efeU; high-affinity iron transporter	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
higB-1; toxin HigB-1	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
K00375; GntR family transcriptional regulator / MocR family aminotransferase	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
K06921; uncharacterized protein	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
K07097; uncharacterized protein	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
K09155; uncharacterized protein	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
kptA; putative RNA 2’-phosphotransferase [EC:2.7.1.-]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
licD; lipopolysaccharide cholinephosphotransferase [EC:2.7.8.-]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
lip, TGL2; triacylglycerol lipase [EC:3.1.1.3]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
nasT; two-component system, response regulator / RNA-binding antiterminator	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
ncd2, npd; nitronate monooxygenase [EC:1.13.12.16]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
nifH; nitrogenase iron protein NifH [EC:1.18.6.1]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
nikA; nickel transport system substrate-binding protein	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
nikB; nickel transport system permease protein	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
nikC; nickel transport system permease protein	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
nikD; nickel transport system ATP-binding protein [EC:3.6.3.24]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
nikE; nickel transport system ATP-binding protein [EC:3.6.3.24]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
p19, ftrA; periplasmic iron binding protein	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
pabA; para-aminobenzoate synthetase component II [EC:2.6.1.85]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
pabB; para-aminobenzoate synthetase component I [EC:2.6.1.85]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
pepE; dipeptidase E [EC:3.4.13.21]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
phnC; phosphonate transport system ATP-binding protein [EC:3.6.3.28]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
phnD; phosphonate transport system substrate-binding protein	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
phnE; phosphonate transport system permease protein	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
pip; proline iminopeptidase [EC:3.4.11.5]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
ppnN; pyrimidine/purine-5’-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
troA, mntA, znuA; manganese/zinc/iron transport system substrate-binding protein	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
troB, mntB, znuC; manganese/zinc/iron transport system ATP- binding protein	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
troC, mntC, znuB; manganese/zinc/iron transport system permease protein	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
troD, mntD, znuB; manganese/zinc/iron transport system permease protein	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
trpB; tryptophan synthase beta chain [EC:4.2.1.20]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
UGCG; ceramide glucosyltransferase [EC:2.4.1.80]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
waaL, rfaL; O-antigen ligase [EC:2.4.1.-]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
xlyAB; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
yoeB; toxin YoeB [EC:3.1.-.-]	0.02919	0.00301	0.03721	0.00151	0.00483	65	0.02358	0.00130	0.00375	93	0.00611	2.23029	131.192	0.02743	0.08455
cwlK; peptidoglycan LD-endopeptidase CwlK [EC:3.4.-.-]	0.02907	0.00461	0.03470	0.00386	0.00771	65	0.02513	0.00302	0.00570	93	0.00958	0.99815	126.733	0.32011	0.37321
ABC-2.A; ABC-2 type transport system ATP-binding protein	0.02685	0.00297	0.03152	0.00145	0.00473	65	0.02359	0.00135	0.00380	93	0.00607	1.30644	134.476	0.19363	0.24342
K07150; uncharacterized protein	0.02685	0.00297	0.03152	0.00145	0.00473	65	0.02359	0.00135	0.00380	93	0.00607	1.30644	134.476	0.19363	0.24342
cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 3.6.4.-]	0.02554	0.00291	0.03140	0.00144	0.00471	65	0.02145	0.00123	0.00364	93	0.00596	1.67112	130.833	0.09709	0.13227
cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]	0.02554	0.00291	0.03140	0.00144	0.00471	65	0.02145	0.00123	0.00364	93	0.00596	1.67112	130.833	0.09709	0.13227
cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]	0.02554	0.00291	0.03140	0.00144	0.00471	65	0.02145	0.00123	0.00364	93	0.00596	1.67112	130.833	0.09709	0.13227
ABC.SN.A; NitT/TauT family transport system ATP-binding protein	0.02395	0.00394	0.02896	0.00291	0.00669	65	0.02045	0.00212	0.00477	93	0.00822	1.03446	123.447	0.30294	0.35353
parA, soj; chromosome partitioning protein	0.02395	0.00394	0.02896	0.00291	0.00669	65	0.02045	0.00212	0.00477	93	0.00822	1.03446	123.447	0.30294	0.35353
ssuB; sulfonate transport system ATP-binding protein [EC:3.6.3.-]	0.02395	0.00394	0.02896	0.00291	0.00669	65	0.02045	0.00212	0.00477	93	0.00822	1.03446	123.447	0.30294	0.35353
mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	0.02264	0.00389	0.02884	0.00292	0.00670	65	0.01831	0.00201	0.00465	93	0.00815	1.29164	120.949	0.19894	0.24934
res; type III restriction enzyme [EC:3.1.21.5]	0.02264	0.00389	0.02884	0.00292	0.00670	65	0.01831	0.00201	0.00465	93	0.00815	1.29164	120.949	0.19894	0.24934
fucA; L-fuculose-phosphate aldolase [EC:4.1.2.17]	0.02173	0.00277	0.02577	0.00130	0.00448	65	0.01891	0.00114	0.00350	93	0.00568	1.20814	131.818	0.22916	0.26869
algI; alginate O-acetyltransferase complex protein AlgI	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
cas5t; CRISPR-associated protein Cas5t	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
cst1, cas8a; CRISPR-associated protein Cst1	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
cst2, cas7; CRISPR-associated protein Cst2	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
dctM; C4-dicarboxylate transporter, DctM subunit	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
dsdA; D-serine dehydratase [EC:4.3.1.18]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
E4.1.3.4, HMGCL, hmgL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
ENDOG; endonuclease G, mitochondrial	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
fixC; electron transfer flavoprotein-quinone oxidoreductase [EC:1.5.5.-]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
fwdE, fmdE; formylmethanofuran dehydrogenase subunit E [EC:1.2.7.12]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
gfrE; glucoselysine-6-phosphate deglycase	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
gfrF; fructoselysine-6-phosphate deglycase	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
glcD; glycolate oxidase [EC:1.1.3.15]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
IDH3; isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
idnO; gluconate 5-dehydrogenase [EC:1.1.1.69]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
K07032; uncharacterized protein	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
K09780; uncharacterized protein	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
K13653; AraC family transcriptional regulator	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
lldG; L-lactate dehydrogenase complex protein LldG	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
LRA3, yfaW; L-rhamnonate dehydratase [EC:4.2.1.90]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
menA; 1,4-dihydroxy-2-naphthoate octaprenyltransferase [EC:2.5.1.74 2.5.1.-]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
metC; cystathionine beta-lyase [EC:4.4.1.8]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
mtnA; methylthioribose-1-phosphate isomerase [EC:5.3.1.23]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
mtnK; 5-methylthioribose kinase [EC:2.7.1.100]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
ppa; inorganic pyrophosphatase [EC:3.6.1.1]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
PTS-Bgl-EIIC, bglF, bglP; PTS system, beta-glucoside-specific IIC component	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
PTS-Gfr-EIIA, gfrA; PTS system, fructoselysine/glucoselysine-specific IIA component [EC:2.7.1.-]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
PTS-Gfr-EIIB, gfrB; PTS system, fructoselysine/glucoselysine-specific IIB component [EC:2.7.1.-]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
PTS-Gfr-EIIC, gfrC; PTS system, fructoselysine/glucoselysine-specific IIC component	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
PTS-Gfr-EIID, gfrD; PTS system, fructoselysine/glucoselysine-specific IID component	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
sauS; sulfoacetaldehyde dehydrogenase [EC:1.2.1.81]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
speG, SAT; diamine N-acetyltransferase [EC:2.3.1.57]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
TC.CITMHS; citrate-Mg2+:H+ or citrate-Ca2+:H+ symporter, CitMHS family	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
wbpO; UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.-]	0.02043	0.00268	0.02566	0.00129	0.00446	65	0.01677	0.00101	0.00329	93	0.00554	1.60410	126.567	0.11118	0.14417
mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-]	0.01753	0.00360	0.02310	0.00254	0.00625	65	0.01363	0.00169	0.00426	93	0.00757	1.25171	119.388	0.21312	0.25423
mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC	0.01753	0.00360	0.02310	0.00254	0.00625	65	0.01363	0.00169	0.00426	93	0.00757	1.25171	119.388	0.21312	0.25423
pezT; UDP-N-acetylglucosamine kinase [EC:2.7.1.176]	0.01753	0.00360	0.02310	0.00254	0.00625	65	0.01363	0.00169	0.00426	93	0.00757	1.25171	119.388	0.21312	0.25423
TC.SSS; solute:Na+ symporter, SSS family	0.01649	0.00276	0.01752	0.00096	0.00385	65	0.01577	0.00139	0.00386	93	0.00545	0.32022	151.114	0.74924	0.75696
K03710; GntR family transcriptional regulator	0.01535	0.00408	0.01723	0.00257	0.00629	65	0.01405	0.00269	0.00538	93	0.00828	0.38403	139.836	0.70154	0.73730
ABC.SN.P; NitT/TauT family transport system permease protein	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
ABC.SN.S; NitT/TauT family transport system substrate-binding protein	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
dinB; DNA polymerase IV [EC:2.7.7.7]	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
E1.1.1.3; homoserine dehydrogenase [EC:1.1.1.3]	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42]	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
E3.5.1.81; N-acyl-D-amino-acid deacylase [EC:3.5.1.81]	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
K07491; putative transposase	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
K07727; putative transcriptional regulator	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
lysC; aspartate kinase [EC:2.7.2.4]	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
metF, MTHFR; methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4]	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
rpoN; RNA polymerase sigma-54 factor	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
ssuA; sulfonate transport system substrate-binding protein	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
ssuC; sulfonate transport system permease protein	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
TC.APA; basic amino acid/polyamine antiporter, APA family	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
thrC; threonine synthase [EC:4.2.3.1]	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-]	0.01519	0.00240	0.01741	0.00096	0.00385	65	0.01364	0.00087	0.00306	93	0.00492	0.76641	133.362	0.44479	0.50897
asrA; anaerobic sulfite reductase subunit A	0.01388	0.00229	0.01729	0.00097	0.00386	65	0.01150	0.00073	0.00280	93	0.00477	1.21546	125.263	0.22648	0.26631
asrB; anaerobic sulfite reductase subunit B	0.01388	0.00229	0.01729	0.00097	0.00386	65	0.01150	0.00073	0.00280	93	0.00477	1.21546	125.263	0.22648	0.26631
asrC; anaerobic sulfite reductase subunit C	0.01388	0.00229	0.01729	0.00097	0.00386	65	0.01150	0.00073	0.00280	93	0.00477	1.21546	125.263	0.22648	0.26631
capD; UDP-glucose 4-epimerase [EC:5.1.3.2]	0.01388	0.00229	0.01729	0.00097	0.00386	65	0.01150	0.00073	0.00280	93	0.00477	1.21546	125.263	0.22648	0.26631
E2.2.1.6S, ilvH, ilvN; acetolactate synthase I/III small subunit [EC:2.2.1.6]	0.01388	0.00229	0.01729	0.00097	0.00386	65	0.01150	0.00073	0.00280	93	0.00477	1.21546	125.263	0.22648	0.26631
ilvC; ketol-acid reductoisomerase [EC:1.1.1.86]	0.01388	0.00229	0.01729	0.00097	0.00386	65	0.01150	0.00073	0.00280	93	0.00477	1.21546	125.263	0.22648	0.26631
ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	0.01388	0.00229	0.01729	0.00097	0.00386	65	0.01150	0.00073	0.00280	93	0.00477	1.21546	125.263	0.22648	0.26631
K07089; uncharacterized protein	0.01388	0.00229	0.01729	0.00097	0.00386	65	0.01150	0.00073	0.00280	93	0.00477	1.21546	125.263	0.22648	0.26631
leuC, IPMI-L; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]	0.01388	0.00229	0.01729	0.00097	0.00386	65	0.01150	0.00073	0.00280	93	0.00477	1.21546	125.263	0.22648	0.26631
leuD, IPMI-S; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]	0.01388	0.00229	0.01729	0.00097	0.00386	65	0.01150	0.00073	0.00280	93	0.00477	1.21546	125.263	0.22648	0.26631
metY; O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49]	0.01388	0.00229	0.01729	0.00097	0.00386	65	0.01150	0.00073	0.00280	93	0.00477	1.21546	125.263	0.22648	0.26631
tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]	0.01388	0.00229	0.01729	0.00097	0.00386	65	0.01150	0.00073	0.00280	93	0.00477	1.21546	125.263	0.22648	0.26631
TC.BAT1; bacterial/archaeal transporter family protein	0.01388	0.00229	0.01729	0.00097	0.00386	65	0.01150	0.00073	0.00280	93	0.00477	1.21546	125.263	0.22648	0.26631
wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14]	0.01388	0.00229	0.01729	0.00097	0.00386	65	0.01150	0.00073	0.00280	93	0.00477	1.21546	125.263	0.22648	0.26631
xerC; integrase/recombinase XerC	0.01388	0.00229	0.01729	0.00097	0.00386	65	0.01150	0.00073	0.00280	93	0.00477	1.21546	125.263	0.22648	0.26631
accB, bccP; acetyl-CoA carboxylase biotin carboxyl carrier protein	0.01154	0.00282	0.01160	0.00114	0.00419	65	0.01150	0.00135	0.00380	93	0.00566	0.01695	144.591	0.98650	0.98650
E3.1.3.97; 3’,5’-nucleoside bisphosphate phosphatase [EC:3.1.3.97]	0.01154	0.00282	0.01160	0.00114	0.00419	65	0.01150	0.00135	0.00380	93	0.00566	0.01695	144.591	0.98650	0.98650
FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	0.01154	0.00282	0.01160	0.00114	0.00419	65	0.01150	0.00135	0.00380	93	0.00566	0.01695	144.591	0.98650	0.98650
lacI, galR; LacI family transcriptional regulator	0.01154	0.00282	0.01160	0.00114	0.00419	65	0.01150	0.00135	0.00380	93	0.00566	0.01695	144.591	0.98650	0.98650
PTS-MalGlc-EIIC, malX; PTS system, maltose/glucose-specific IIC component	0.01154	0.00282	0.01160	0.00114	0.00419	65	0.01150	0.00135	0.00380	93	0.00566	0.01695	144.591	0.98650	0.98650
xdhC; xanthine dehydrogenase accessory factor	0.01024	0.00272	0.01148	0.00114	0.00420	65	0.00936	0.00120	0.00359	93	0.00552	0.38403	139.836	0.70154	0.73730
cysE; serine O-acetyltransferase [EC:2.3.1.30]	0.01007	0.00195	0.01166	0.00063	0.00312	65	0.00895	0.00058	0.00250	93	0.00400	0.67740	134.035	0.49932	0.56875
DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]	0.01007	0.00195	0.01166	0.00063	0.00312	65	0.00895	0.00058	0.00250	93	0.00400	0.67740	134.035	0.49932	0.56875
E4.3.1.15; diaminopropionate ammonia-lyase [EC:4.3.1.15]	0.01007	0.00195	0.01166	0.00063	0.00312	65	0.00895	0.00058	0.00250	93	0.00400	0.67740	134.035	0.49932	0.56875
pdxA; 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262]	0.01007	0.00195	0.01166	0.00063	0.00312	65	0.00895	0.00058	0.00250	93	0.00400	0.67740	134.035	0.49932	0.56875
thrB1; homoserine kinase [EC:2.7.1.39]	0.01007	0.00195	0.01166	0.00063	0.00312	65	0.00895	0.00058	0.00250	93	0.00400	0.67740	134.035	0.49932	0.56875
ARSC2, arsC; arsenate reductase [EC:1.20.4.1]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
barA, gacS, varS; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
crcB, FEX; fluoride exporter	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
csm1, cas10; CRISPR-associated protein Csm1	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
csm3; CRISPR-associated protein Csm3	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
csm4; CRISPR-associated protein Csm4	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
cusR, copR, silR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
cysI; sulfite reductase (NADPH) hemoprotein beta-component [EC:1.8.1.2]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
DOPA; 4,5-DOPA dioxygenase extradiol [EC:1.13.11.-]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
E2.6.1.-E, patB; aminotransferase [EC:2.6.1.-]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
E3.1.21.4; type II restriction enzyme [EC:3.1.21.4]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
FLOT; flotillin	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
K06905; uncharacterized protein	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
K06906; uncharacterized protein	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
K06907; uncharacterized protein	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
K06908; uncharacterized protein	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
K07126; uncharacterized protein	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
K09935; uncharacterized protein	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
K15024; putative phosphotransacetylase [EC:2.3.1.8]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
leuB, IMDH; 3-isopropylmalate dehydrogenase [EC:1.1.1.85]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
metA; homoserine O-succinyltransferase/O-acetyltransferase [EC:2.3.1.46 2.3.1.31]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
oraE; D-ornithine 4,5-aminomutase subunit beta [EC:5.4.3.5]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
oraS; D-ornithine 4,5-aminomutase subunit alpha [EC:5.4.3.5]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
pduC; propanediol dehydratase large subunit [EC:4.2.1.28]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
pduD; propanediol dehydratase medium subunit [EC:4.2.1.28]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
pduE; propanediol dehydratase small subunit [EC:4.2.1.28]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
pduP; propionaldehyde dehydrogenase [EC:1.2.1.87]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
pphA; serine/threonine protein phosphatase 1 [EC:3.1.3.16]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
racD; aspartate racemase [EC:5.1.1.13]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
rocR; arginine utilization regulatory protein	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.22.4]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
secB; preprotein translocase subunit SecB	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
sir; sulfite reductase (ferredoxin) [EC:1.8.7.1]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
topB; DNA topoisomerase III [EC:5.99.1.2]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
trbL; type IV secretion system protein TrbL	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
virB10, lvhB10; type IV secretion system protein VirB10	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
virB11, lvhB11; type IV secretion system protein VirB11	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
virB4, lvhB4; type IV secretion system protein VirB4	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
virB5, lvhB5; type IV secretion system protein VirB5	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
virB9, lvhB9; type IV secretion system protein VirB9	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
virD4, lvhD4; type IV secretion system protein VirD4	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
wbjC; UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase [EC:1.1.1.367]	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
xtmB; phage terminase large subunit	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
yefM; antitoxin YefM	0.00876	0.00180	0.01155	0.00063	0.00313	65	0.00682	0.00042	0.00213	93	0.00378	1.25171	119.388	0.21312	0.25423
accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
argG, ASS1; argininosuccinate synthase [EC:6.3.4.5]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
argH, ASL; argininosuccinate lyase [EC:4.3.2.1]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
aspA; aspartate ammonia-lyase [EC:4.3.1.1]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
cdd, CDA; cytidine deaminase [EC:3.5.4.5]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
dapF; diaminopimelate epimerase [EC:5.1.1.7]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
dapH, dapD; tetrahydrodipicolinate N-acetyltransferase [EC:2.3.1.89]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
deoC, DERA; deoxyribose-phosphate aldolase [EC:4.1.2.4]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
dfx; superoxide reductase [EC:1.15.1.2]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
E2.7.7.24, rfbA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
E4.2.1.2AA, fumA; fumarate hydratase subunit alpha [EC:4.2.1.2]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
E4.2.1.2AB, fumB; fumarate hydratase subunit beta [EC:4.2.1.2]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
gltD; glutamate synthase (NADPH/NADH) small chain [EC:1.4.1.13 1.4.1.14]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
glxK, garK; glycerate 2-kinase [EC:2.7.1.165]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
K06871; uncharacterized protein	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
K07019; uncharacterized protein	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
K07166; ACT domain-containing protein	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
K09157; uncharacterized protein	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
K09775; uncharacterized protein	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
manA, MPI; mannose-6-phosphate isomerase [EC:5.3.1.8]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
ME2, sfcA, maeA; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
msmX, msmK, malK, sugC, ggtA, msiK; multiple sugar transport system ATP-binding protein	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
nagC; N-acetylglucosamine repressor	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
nuoE; NADH-quinone oxidoreductase subunit E [EC:1.6.5.3]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
nuoG; NADH-quinone oxidoreductase subunit G [EC:1.6.5.3]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
patA; aminotransferase [EC:2.6.1.-]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
pct; propionate CoA-transferase [EC:2.8.3.1]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
pdxK, pdxY; pyridoxine kinase [EC:2.7.1.35]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
phoB1, phoP; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
phoH2; PhoH-like ATPase	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
phoU; phosphate transport system protein	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
pstA; phosphate transport system permease protein	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
pstB; phosphate transport system ATP-binding protein [EC:3.6.3.27]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
pstS; phosphate transport system substrate-binding protein	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
PTS-Dgl-EIIC, gamP; PTS system, D-glucosamine-specific IIC component	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
PTS-Scr-EIIC, scrA, sacP, sacX, ptsS; PTS system, sucrose-specific IIC component	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
RP-S1, rpsA; small subunit ribosomal protein S1	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
rph; ribonuclease PH [EC:2.7.7.56]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
TC.NCS2; nucleobase:cation symporter-2, NCS2 family	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
udk, UCK; uridine kinase [EC:2.7.1.48]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
virK; uncharacterized protein	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22]	0.00642	0.00157	0.00586	0.00029	0.00210	65	0.00682	0.00047	0.00224	93	0.00307	-0.31406	153.988	0.75390	0.75696
ABC.SP.A; putative spermidine/putrescine transport system ATP-binding protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
ABC.SP.P; putative spermidine/putrescine transport system permease protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
ABC.SP.P1; putative spermidine/putrescine transport system permease protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
ABC.SP.S; putative spermidine/putrescine transport system substrate-binding protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
ade; adenine deaminase [EC:3.5.4.2]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
ampS, pepS, ampT; aminopeptidase [EC:3.4.11.-]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
comB; 2-phosphosulfolactate phosphatase [EC:3.1.3.71]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
coxS; aerobic carbon-monoxide dehydrogenase small subunit [EC:1.2.5.3]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
cpg; glutamate carboxypeptidase [EC:3.4.17.11]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
croR; 3-hydroxybutyryl-CoA dehydratase [EC:4.2.1.55]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
cynT, can; carbonic anhydrase [EC:4.2.1.1]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
cysZ; CysZ protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
deoB; phosphopentomutase [EC:5.4.2.7]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
dnaC; DNA replication protein DnaC	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
DPYS, dht, hydA; dihydropyrimidinase [EC:3.5.2.2]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
E2.7.1.4, scrK; fructokinase [EC:2.7.1.4]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
E3.2.1.86B, bglA; 6-phospho-beta-glucosidase [EC:3.2.1.86]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
elaA; ElaA protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
feoA; ferrous iron transport protein A	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
feoB; ferrous iron transport protein B	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
glvA; maltose-6’-phosphate glucosidase [EC:3.2.1.122]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
hdrA2; heterodisulfide reductase subunit A2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
hdrB2; heterodisulfide reductase subunit B2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
hdrC2; heterodisulfide reductase subunit C2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
hipO; hippurate hydrolase [EC:3.5.1.32]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
hndA; NADP-reducing hydrogenase subunit HndA [EC:1.12.1.3]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
hndC; NADP-reducing hydrogenase subunit HndC [EC:1.12.1.3]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
hndD; NADP-reducing hydrogenase subunit HndD [EC:1.12.1.3]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
hslU; ATP-dependent HslUV protease ATP-binding subunit HslU	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
hslV, clpQ; ATP-dependent HslUV protease, peptidase subunit HslV [EC:3.4.25.2]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
K01138; uncharacterized sulfatase [EC:3.1.6.-]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
K07025; putative hydrolase of the HAD superfamily	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
K07040; uncharacterized protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
K07098; uncharacterized protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
K09858; SEC-C motif domain protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
kduD; 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase [EC:1.1.1.127]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
kduI; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase [EC:5.3.1.17]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
lysA; diaminopimelate decarboxylase [EC:4.1.1.20]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
mal; methylaspartate ammonia-lyase [EC:4.3.1.2]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
mgsA; methylglyoxal synthase [EC:4.2.3.3]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
moaA, CNX2; GTP 3’,8-cyclase [EC:4.1.99.22]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
moaC, CNX3; cyclic pyranopterin monophosphate synthase [EC:4.6.1.17]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
modA; molybdate transport system substrate-binding protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
modB; molybdate transport system permease protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
moxR; MoxR-like ATPase [EC:3.6.3.-]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
nfo; deoxyribonuclease IV [EC:3.1.21.2]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
nirA; ferredoxin-nitrite reductase [EC:1.7.7.1]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
nuoF; NADH-quinone oxidoreductase subunit F [EC:1.6.5.3]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
pdhR; GntR family transcriptional regulator, transcriptional repressor for pyruvate dehydrogenase complex	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
pdxT, pdx2; 5’-phosphate synthase pdxT subunit [EC:4.3.3.6]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
pheA; chorismate mutase / prephenate dehydratase [EC:5.4.99.5 4.2.1.51]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
porA; pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
porG; pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
proB; glutamate 5-kinase [EC:2.7.2.11]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
PTS-Cel-EIIA, celC, chbA; PTS system, cellobiose-specific IIA component [EC:2.7.1.196 2.7.1.205]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
PTS-Cel-EIIB, celA, chbB; PTS system, cellobiose-specific IIB component [EC:2.7.1.196 2.7.1.205]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
PTS-Cel-EIIC, celB, chbC; PTS system, cellobiose-specific IIC component	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
pyrG, CTPS; CTP synthase [EC:6.3.4.2]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
rbsA; ribose transport system ATP-binding protein [EC:3.6.3.17]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
rbsB; ribose transport system substrate-binding protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
rbsC; ribose transport system permease protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
rbsD; D-ribose pyranase [EC:5.4.99.62]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
rbsK, RBKS; ribokinase [EC:2.7.1.15]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
rlmA1; 23S rRNA (guanine745-N1)-methyltransferase [EC:2.1.1.187]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
rpoE; DNA-directed RNA polymerase subunit delta	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
sdhA, frdA; succinate dehydrogenase / fumarate reductase, flavoprotein subunit [EC:1.3.5.1 1.3.5.4]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
selA; L-seryl-tRNA(Ser) seleniumtransferase [EC:2.9.1.1]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
selB, EEFSEC; selenocysteine-specific elongation factor	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
selD, SEPHS; selenide, water dikinase [EC:2.7.9.3]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
selU; tRNA 2-selenouridine synthase [EC:2.9.1.-]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
sfsA; sugar fermentation stimulation protein A	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
spmA; spore maturation protein A	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
TC.ZIP, zupT, ZRT3, ZIP2; zinc transporter, ZIP family	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
thiB, tbpA; thiamine transport system substrate-binding protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
thiP; thiamine transport system permease protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
ubiB, aarF; ubiquinone biosynthesis protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
urdA; urocanate reductase [EC:1.3.99.33]	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
yabN; tetrapyrrole methylase family protein / MazG family protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
yaeR; glyoxylase I family protein	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
ycdX; putative hydrolase	0.00512	0.00136	0.00574	0.00029	0.00210	65	0.00468	0.00030	0.00179	93	0.00276	0.38403	139.836	0.70154	0.73730
abfD; 4-hydroxybutyryl-CoA dehydratase / vinylacetyl-CoA-Delta-isomerase [EC:4.2.1.120 5.3.3.3]	0.00131	0.00084	0.00011	0.00000	0.00011	65	0.00214	0.00019	0.00142	93	0.00143	-1.42000	93.176	0.15894	0.20186
dapD; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [EC:2.3.1.117]	0.00131	0.00084	0.00011	0.00000	0.00011	65	0.00214	0.00019	0.00142	93	0.00143	-1.42000	93.176	0.15894	0.20186
DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4]	0.00131	0.00084	0.00011	0.00000	0.00011	65	0.00214	0.00019	0.00142	93	0.00143	-1.42000	93.176	0.15894	0.20186
mgtA, mgtB; Mg2+-importing ATPase [EC:3.6.3.2]	0.00131	0.00084	0.00011	0.00000	0.00011	65	0.00214	0.00019	0.00142	93	0.00143	-1.42000	93.176	0.15894	0.20186
murR; RpiR family transcriptional regulator, murPQ operon repressor	0.00131	0.00084	0.00011	0.00000	0.00011	65	0.00214	0.00019	0.00142	93	0.00143	-1.42000	93.176	0.15894	0.20186
pheC; cyclohexadienyl dehydratase [EC:4.2.1.51 4.2.1.91]	0.00131	0.00084	0.00011	0.00000	0.00011	65	0.00214	0.00019	0.00142	93	0.00143	-1.42000	93.176	0.15894	0.20186
pstC; phosphate transport system permease protein	0.00131	0.00084	0.00011	0.00000	0.00011	65	0.00214	0.00019	0.00142	93	0.00143	-1.42000	93.176	0.15894	0.20186
PTS-Fru2-EIIB; PTS system, fructose-specific IIB-like component [EC:2.7.1.-]	0.00131	0.00084	0.00011	0.00000	0.00011	65	0.00214	0.00019	0.00142	93	0.00143	-1.42000	93.176	0.15894	0.20186
PTS-Ula-EIIA, ulaC, sgaA; PTS system, ascorbate-specific IIA component [EC:2.7.1.194]	0.00131	0.00084	0.00011	0.00000	0.00011	65	0.00214	0.00019	0.00142	93	0.00143	-1.42000	93.176	0.15894	0.20186
PTS-Ula-EIIB, ulaB, sgaB; PTS system, ascorbate-specific IIB component [EC:2.7.1.194]	0.00131	0.00084	0.00011	0.00000	0.00011	65	0.00214	0.00019	0.00142	93	0.00143	-1.42000	93.176	0.15894	0.20186
PTS-Ula-EIIC, ulaA, sgaT; PTS system, ascorbate-specific IIC component	0.00131	0.00084	0.00011	0.00000	0.00011	65	0.00214	0.00019	0.00142	93	0.00143	-1.42000	93.176	0.15894	0.20186
recT; recombination protein RecT	0.00131	0.00084	0.00011	0.00000	0.00011	65	0.00214	0.00019	0.00142	93	0.00143	-1.42000	93.176	0.15894	0.20186
rlpA; rare lipoprotein A	0.00131	0.00084	0.00011	0.00000	0.00011	65	0.00214	0.00019	0.00142	93	0.00143	-1.42000	93.176	0.15894	0.20186
udp, UPP; uridine phosphorylase [EC:2.4.2.3]	0.00131	0.00084	0.00011	0.00000	0.00011	65	0.00214	0.00019	0.00142	93	0.00143	-1.42000	93.176	0.15894	0.20186
xtmA; phage terminase small subunit	0.00131	0.00084	0.00011	0.00000	0.00011	65	0.00214	0.00019	0.00142	93	0.00143	-1.42000	93.176	0.15894	0.20186

plot.dat <- tb.ra %>%
  arrange(desc(`Overall Mean`)) %>%
  slice_head(n=50)%>%
  mutate(
    description = fct_reorder(description, `Overall Mean`),
    description = factor(description, levels = levels(description), ordered=T)
  ) %>%
  arrange(description) %>%
  mutate(
    id = 1:n(),
    step = ifelse(id%%2 == 0, 1, 0),
    Mean_diff = `Tumor Mean` - `Non-Tumor Mean`,
    Mean_diff_ll = Mean_diff - qt(0.975, df)*SEpooled,
    Mean_diff_ul = Mean_diff + qt(0.975, df)*SEpooled
  ) %>%
  pivot_longer(
    cols=contains("Mean"),
    names_to = "group",
    values_to = "mean"
  )



p1.d <- plot.dat %>%
  filter(group %in% c("Tumor Mean","Non-Tumor Mean")) %>%
  mutate(
    group = ifelse(group == "Tumor Mean", "Tumor", "Non-Tumor"),
    col = ifelse(step == 1, "grey90", "white"),
    h=1, w=Inf
    
  )
p1 <- ggplot()+
  geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_bar(data=p1.d,
             aes(x=mean, y=description,
                 group=group, color=group,
                 fill=group),
             stat="identity",position = "dodge",
             alpha = 1)+
    labs(x="Mean RelAbundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      plot.margin = unit(c(1,0,1,1), "lines")
    )

p2.d <- plot.dat %>%
  filter(group %in% c("Mean_diff", "Mean_diff_ll", "Mean_diff_ul")) %>%
  pivot_wider(
    names_from = group,
    values_from = mean
  ) %>%
  mutate(
    group = ifelse(Mean_diff > 0, "Tumor", "Non-Tumor"),
    p = sprintf("%.3f", round(fdr_p,3)),
    ll = min(Mean_diff_ll)-0.01,
    ul = max(Mean_diff_ul)+0.01
  )
p2<-ggplot(p2.d, aes(x=Mean_diff, y=description))+
    geom_tile(data = p1.d,
              aes(y = description, x=0,
                  height=h, width=w),
              fill = p1.d$col, color=p1.d$col)+
    geom_vline(xintercept = 0, linetype="dashed", alpha=0.5)+
    geom_segment(aes(x=Mean_diff_ll, y=description, xend=Mean_diff_ul, yend=description))+
    geom_point(aes(fill=group, color=group))+
    geom_text(aes(label=p, x=unique(ul)+0.025))+
    coord_cartesian(xlim = c(unique(p2.d$ll), unique(p2.d$ul)),
                    clip = 'off') +
    annotate("text", x=unique(p2.d$ul)+0.05,y = 25,
             angle=90,
             label="q-value (FDR Corrected p-value)")+
    labs(x="Mean Difference in RelAbundance")+
    theme_classic()+
    theme(
      legend.position = "bottom",
      axis.title.y = element_blank(),
      axis.text.y = element_blank(),
      axis.line.y = element_blank(),
      axis.ticks.y = element_blank(),
      plot.margin = unit(c(1,4,1,0), "lines")
    )

# plot
p <- p1 + p2 +
  plot_annotation(title="Stratefied KO Data - Fusobacterium nucleatum: 50 most abundant descriptions")
p

ggsave("output/updated-figures-2021-05-20/picrust-fuso-KO.pdf",p,units="in", height=12, width=10)

Modeling Difference between Tumor and Non-Tumor

For the modeling, we used a generalized linear mixed model (GLMM).

First, we looked at the biserial correlation between the abundance of each description and the tumor status.

tb <- mydata %>%
  group_by(description)%>%
  summarise(
    r = cor(tumor, RelAbundance)
  ) %>%
  mutate(
    M=mean(r)
  )

ggplot(tb, aes(x=r))+
  geom_density()+
  geom_vline(aes(xintercept = M))+
  labs(x="Biserial Correlation",title="Relationship between description abundance and tumor (tumor vs. non-tumor)")+
  theme(panel.grid = element_blank())

Next, we need the data to be on an interpretable scale. First, let’s use the raw abundance like scale.

p <- ggplot(mydata, aes(x=Abundance))+
  geom_density()
p

mydata <- mydata %>%
  mutate(Abundance.dich=ifelse(Abundance==0, 0, 1))
table(mydata$Abundance.dich)

     0      1 
122745  72701 

Let’s first run models by description so that we can avoid the nesting issue initially. We will come back to this to conduct the final model (it will be more powerful).

DESCRIPTIONS <- unique(mydata$description)
i<-1
dat0 <- mydata %>% filter(description==DESCRIPTIONS[i])

# quasipossion (approximately negative binom) give an approx. answer.
fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
summary(fit0)

Call:
glm(formula = Abundance ~ 1 + tumor, family = quasipoisson(link = "log"), 
    data = dat0)

Deviance Residuals: 
   Min      1Q  Median      3Q     Max  
 -9.69   -8.03   -5.55   -4.32   53.32  

Coefficients:
            Estimate Std. Error t value    Pr(>|t|)    
(Intercept)    2.735      0.457    5.99 0.000000014 ***
tumor          1.115      0.553    2.02       0.046 *  
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

(Dispersion parameter for quasipoisson family taken to be 298.67)

    Null deviance: 19688  on 157  degrees of freedom
Residual deviance: 18365  on 156  degrees of freedom
AIC: NA

Number of Fisher Scoring iterations: 7

NExt, let’s model the percent relative abundance. This will allow us to make inference about the difference average relative abundance. Which is a simpler interpretation than trying to model differences in the log relative abundance which will need to be interpreted as the multiplicative relative change.

results.out <- as.data.frame(matrix(ncol=4, nrow=length(DESCRIPTIONS)))
colnames(results.out) <- c("description", "Est", "SE", "p")
#results.out$description <-DESCRIPTIONS

i <- 1
for(i in 1:length(DESCRIPTIONS)){
#for(i in 1:5){ 
  dat0 <- mydata %>%
    filter(description == DESCRIPTIONS[i])
  fit0 <- glm(
  Abundance ~ 1 + tumor,
  data= dat0,
  family=quasipoisson(link = "log")
)
  fit.sum <- summary(fit0)
  results.out[i, 1] <- DESCRIPTIONS[i]
  results.out[i, 2:4] <- fit.sum$coefficients[2, c(1,2,4)]
}

results.out$fdr_p <- p.adjust(results.out$p, method="fdr")

kable(results.out, format="html", digits=3) %>%
  kable_styling(full_width = T)%>%
  scroll_box(width="100%", height="600px")

description	Est	SE	p	fdr_p
AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]	1.115	0.553	0.046	0.058
ABC-2.A; ABC-2 type transport system ATP-binding protein	1.111	0.570	0.053	0.065
ABC-2.P; ABC-2 type transport system permease protein	1.155	0.607	0.059	0.072
ABC.CD.A; putative ABC transport system ATP-binding protein	1.185	0.571	0.040	0.058
ABC.CD.P; putative ABC transport system permease protein	1.223	0.582	0.037	0.058
ABC.FEV.A; iron complex transport system ATP-binding protein [EC:3.6.3.34]	1.206	0.582	0.040	0.058
ABC.FEV.P; iron complex transport system permease protein	1.225	0.584	0.038	0.058
ABC.FEV.S; iron complex transport system substrate-binding protein	1.240	0.596	0.039	0.058
ABC.PA.A; polar amino acid transport system ATP-binding protein [EC:3.6.3.21]	0.954	0.514	0.065	0.080
ABC.PA.P; polar amino acid transport system permease protein	0.963	0.504	0.058	0.071
ABC.PA.S; polar amino acid transport system substrate-binding protein	1.013	0.519	0.053	0.065
ABC.PE.A; peptide/nickel transport system ATP-binding protein	1.223	0.582	0.037	0.058
ABC.PE.A1; peptide/nickel transport system ATP-binding protein	1.246	0.592	0.037	0.058
ABC.PE.P; peptide/nickel transport system permease protein	1.240	0.593	0.038	0.058
ABC.PE.P1; peptide/nickel transport system permease protein	1.240	0.593	0.038	0.058
ABC.PE.S; peptide/nickel transport system substrate-binding protein	1.098	0.552	0.048	0.062
ABC.SN.A; NitT/TauT family transport system ATP-binding protein	0.306	0.561	0.586	0.629
ABC.SN.P; NitT/TauT family transport system permease protein	0.087	0.625	0.890	0.893
ABC.SN.S; NitT/TauT family transport system substrate-binding protein	0.087	0.625	0.890	0.893
ABC.SP.A; putative spermidine/putrescine transport system ATP-binding protein	0.551	0.679	0.419	0.451
ABC.SP.P; putative spermidine/putrescine transport system permease protein	0.551	0.679	0.419	0.451
ABC.SP.P1; putative spermidine/putrescine transport system permease protein	0.551	0.679	0.419	0.451
ABC.SP.S; putative spermidine/putrescine transport system substrate-binding protein	0.551	0.679	0.419	0.451
ABC.SS.A; simple sugar transport system ATP-binding protein [EC:3.6.3.17]	1.115	0.553	0.046	0.058
ABC.SS.P; simple sugar transport system permease protein	1.115	0.553	0.046	0.058
ABC.X4.A; putative ABC transport system ATP-binding protein	1.119	0.539	0.040	0.058
ABC.X4.P; putative ABC transport system permease protein	1.119	0.539	0.040	0.058
ABC.X4.S; putative ABC transport system substrate-binding protein	0.979	0.537	0.070	0.085
ABC.ZM.S; zinc/manganese transport system substrate-binding protein	1.352	0.629	0.033	0.058
ABCB-BAC; ATP-binding cassette, subfamily B, bacterial	1.144	0.562	0.044	0.058
ABCC-BAC; ATP-binding cassette, subfamily C, bacterial	1.352	0.629	0.033	0.058
ABCF3; ATP-binding cassette, subfamily F, member 3	1.115	0.553	0.046	0.058
abfD; 4-hydroxybutyryl-CoA dehydratase / vinylacetyl-CoA-Delta-isomerase [EC:4.2.1.120 5.3.3.3]	-1.604	1.840	0.385	0.450
abgT; aminobenzoyl-glutamate transport protein	1.113	0.561	0.049	0.062
ACADS, bcd; butyryl-CoA dehydrogenase [EC:1.3.8.1]	1.184	0.577	0.042	0.058
accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]	1.115	0.553	0.046	0.058
accB, bccP; acetyl-CoA carboxylase biotin carboxyl carrier protein	0.001	0.653	0.999	0.999
accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	-0.298	0.779	0.702	0.720
accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15]	1.115	0.553	0.046	0.058
ackA; acetate kinase [EC:2.7.2.1]	1.115	0.553	0.046	0.058
acpP; acyl carrier protein	1.115	0.553	0.046	0.058
acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7]	1.115	0.553	0.046	0.058
ACSL, fadD; long-chain acyl-CoA synthetase [EC:6.2.1.3]	1.184	0.577	0.042	0.058
ade; adenine deaminase [EC:3.5.4.2]	0.551	0.679	0.419	0.451
adk, AK; adenylate kinase [EC:2.7.4.3]	1.115	0.553	0.046	0.058
afuA, fbpA; iron(III) transport system substrate-binding protein	1.198	0.557	0.033	0.058
afuB, fbpB; iron(III) transport system permease protein	1.198	0.565	0.035	0.058
afuC, fbpC; iron(III) transport system ATP-binding protein [EC:3.6.3.30]	1.198	0.565	0.035	0.058
ALDO; fructose-bisphosphate aldolase, class I [EC:4.1.2.13]	1.352	0.629	0.033	0.058
algI; alginate O-acetyltransferase complex protein AlgI	1.359	0.653	0.039	0.058
alr; alanine racemase [EC:5.1.1.1]	1.115	0.553	0.046	0.058
amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	1.088	0.505	0.033	0.058
ampS, pepS, ampT; aminopeptidase [EC:3.4.11.-]	0.551	0.679	0.419	0.451
apbE; FAD:protein FMN transferase [EC:2.7.1.180]	1.115	0.553	0.046	0.058
APEH; acylaminoacyl-peptidase [EC:3.4.19.1]	1.115	0.553	0.046	0.058
APRT, apt; adenine phosphoribosyltransferase [EC:2.4.2.7]	1.223	0.582	0.037	0.058
argG, ASS1; argininosuccinate synthase [EC:6.3.4.5]	-0.298	0.779	0.702	0.720
argH, ASL; argininosuccinate lyase [EC:4.3.2.1]	-0.298	0.779	0.702	0.720
aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]	1.115	0.553	0.046	0.058
AROA2, aroA; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	1.115	0.553	0.046	0.058
aroC; chorismate synthase [EC:4.2.3.5]	1.115	0.553	0.046	0.058
aroE; shikimate dehydrogenase [EC:1.1.1.25]	1.286	0.613	0.038	0.058
aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10]	1.115	0.553	0.046	0.058
arsA, ASNA1, GET3; arsenite/tail-anchored protein-transporting ATPase [EC:3.6.3.16 3.6.3.-]	1.359	0.653	0.039	0.058
ARSC1, arsC; arsenate reductase [EC:1.20.4.1]	1.115	0.553	0.046	0.058
ARSC2, arsC; arsenate reductase [EC:1.20.4.1]	1.219	0.577	0.036	0.058
arsR; ArsR family transcriptional regulator, arsenate/arsenite/antimonite-responsive transcriptional repressor	1.119	0.539	0.040	0.058
asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	0.087	0.625	0.890	0.893
asnA; aspartate–ammonia ligase [EC:6.3.1.1]	1.115	0.553	0.046	0.058
aspA; aspartate ammonia-lyase [EC:4.3.1.1]	-0.298	0.779	0.702	0.720
aspB; aspartate aminotransferase [EC:2.6.1.1]	1.115	0.553	0.046	0.058
aspS; aspartyl-tRNA synthetase [EC:6.1.1.12]	1.115	0.553	0.046	0.058
asrA; anaerobic sulfite reductase subunit A	0.802	0.500	0.111	0.131
asrB; anaerobic sulfite reductase subunit B	0.802	0.500	0.111	0.131
asrC; anaerobic sulfite reductase subunit C	0.802	0.500	0.111	0.131
atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9]	1.223	0.591	0.040	0.058
atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9]	1.223	0.591	0.040	0.058
atoE; short-chain fatty acids transporter	1.115	0.553	0.046	0.058
ATPF0A, atpB; F-type H+-transporting ATPase subunit a	1.115	0.553	0.046	0.058
ATPF0B, atpF; F-type H+-transporting ATPase subunit b	1.115	0.553	0.046	0.058
ATPF0C, atpE; F-type H+-transporting ATPase subunit c	1.115	0.553	0.046	0.058
ATPF1A, atpA; F-type H+-transporting ATPase subunit alpha [EC:3.6.3.14]	1.115	0.553	0.046	0.058
ATPF1B, atpD; F-type H+-transporting ATPase subunit beta [EC:3.6.3.14]	1.115	0.553	0.046	0.058
ATPF1D, atpH; F-type H+-transporting ATPase subunit delta	1.115	0.553	0.046	0.058
ATPF1E, atpC; F-type H+-transporting ATPase subunit epsilon	1.115	0.553	0.046	0.058
ATPF1G, atpG; F-type H+-transporting ATPase subunit gamma	1.115	0.553	0.046	0.058
atpI; ATP synthase protein I	1.352	0.629	0.033	0.058
ATPVA, ntpA, atpA; V/A-type H+/Na+-transporting ATPase subunit A [EC:3.6.3.14 3.6.3.15]	1.158	0.588	0.051	0.063
ATPVB, ntpB, atpB; V/A-type H+/Na+-transporting ATPase subunit B	1.158	0.588	0.051	0.063
ATPVC, ntpC, atpC; V/A-type H+/Na+-transporting ATPase subunit C	1.158	0.588	0.051	0.063
ATPVD, ntpD, atpD; V/A-type H+/Na+-transporting ATPase subunit D	1.161	0.572	0.044	0.058
ATPVE, ntpE, atpE; V/A-type H+/Na+-transporting ATPase subunit E	1.158	0.588	0.051	0.063
ATPVF, ntpF, atpF; V/A-type H+/Na+-transporting ATPase subunit F	1.158	0.588	0.051	0.063
ATPVG, ahaH, atpH; V/A-type H+/Na+-transporting ATPase subunit G/H	1.352	0.629	0.033	0.058
ATPVI, ntpI, atpI; V/A-type H+/Na+-transporting ATPase subunit I	1.158	0.588	0.051	0.063
ATPVK, ntpK, atpK; V/A-type H+/Na+-transporting ATPase subunit K	1.158	0.588	0.051	0.063
bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]	1.115	0.553	0.046	0.058
barA, gacS, varS; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]	1.219	0.577	0.036	0.058
bax; Bax protein	1.115	0.553	0.046	0.058
bdhAB; butanol dehydrogenase [EC:1.1.1.-]	1.197	0.573	0.038	0.058
bigA; putative surface-exposed virulence protein	1.343	0.600	0.027	0.058
bioA; adenosylmethionine—8-amino-7-oxononanoate aminotransferase [EC:2.6.1.62]	1.115	0.553	0.046	0.058
bioB; biotin synthase [EC:2.8.1.6]	0.945	0.526	0.074	0.090
bioC; malonyl-CoA O-methyltransferase [EC:2.1.1.197]	1.115	0.553	0.046	0.058
bioD; dethiobiotin synthetase [EC:6.3.3.3]	1.115	0.553	0.046	0.058
bioF; 8-amino-7-oxononanoate synthase [EC:2.3.1.47]	1.115	0.553	0.046	0.058
bioG; pimeloyl-[acyl-carrier protein] methyl ester esterase [EC:3.1.1.85]	1.115	0.553	0.046	0.058
bioY; biotin transport system substrate-specific component	1.352	0.629	0.033	0.058
birA; BirA family transcriptional regulator, biotin operon repressor / biotin—[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	1.115	0.553	0.046	0.058
bshA; L-malate glycosyltransferase [EC:2.4.1.-]	1.136	0.569	0.048	0.061
capD; UDP-glucose 4-epimerase [EC:5.1.3.2]	0.802	0.500	0.111	0.131
carA, CPA1; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]	1.115	0.553	0.046	0.058
carB, CPA2; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]	1.115	0.553	0.046	0.058
CARP, pepA; leucyl aminopeptidase [EC:3.4.11.1]	1.115	0.553	0.046	0.058
CARS, cysS; cysteinyl-tRNA synthetase [EC:6.1.1.16]	1.115	0.553	0.046	0.058
cas1; CRISP-associated protein Cas1	1.115	0.553	0.046	0.058
cas2; CRISPR-associated protein Cas2	1.115	0.553	0.046	0.058
cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 3.6.4.-]	1.292	0.606	0.034	0.058
cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]	1.292	0.606	0.034	0.058
cas5t; CRISPR-associated protein Cas5t	1.359	0.653	0.039	0.058
cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]	1.292	0.606	0.034	0.058
cat2, abfT; 4-hydroxybutyrate CoA-transferase [EC:2.8.3.-]	1.115	0.553	0.046	0.058
cbiB, cobD; adenosylcobinamide-phosphate synthase [EC:6.3.1.10]	1.115	0.553	0.046	0.058
cbiD; cobalt-precorrin-5B (C1)-methyltransferase [EC:2.1.1.195]	1.115	0.553	0.046	0.058
cbiE; cobalt-precorrin-7 (C5)-methyltransferase [EC:2.1.1.289]	1.115	0.553	0.046	0.058
cbiG; cobalt-precorrin 5A hydrolase [EC:3.7.1.12]	1.115	0.553	0.046	0.058
cbiK; sirohydrochlorin cobaltochelatase [EC:4.99.1.3]	1.115	0.553	0.046	0.058
cbiN; cobalt/nickel transport protein	1.250	0.603	0.040	0.058
cbiT; cobalt-precorrin-6B (C15)-methyltransferase [EC:2.1.1.196]	1.115	0.553	0.046	0.058
cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]	1.115	0.553	0.046	0.058
ccdA; cytochrome c-type biogenesis protein	1.223	0.582	0.037	0.058
cdd, CDA; cytidine deaminase [EC:3.5.4.5]	-0.298	0.779	0.702	0.720
CHO1, pssA; CDP-diacylglycerol—serine O-phosphatidyltransferase [EC:2.7.8.8]	1.115	0.553	0.046	0.058
chrA; chromate transporter	1.115	0.553	0.046	0.058
cidA; holin-like protein	1.115	0.553	0.046	0.058
citC; [citrate (pro-3S)-lyase] ligase [EC:6.2.1.22]	1.289	0.586	0.029	0.058
citD; citrate lyase subunit gamma (acyl carrier protein)	1.115	0.553	0.046	0.058
citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34]	1.115	0.553	0.046	0.058
citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10]	1.115	0.553	0.046	0.058
citG; triphosphoribosyl-dephospho-CoA synthase [EC:2.4.2.52]	1.352	0.629	0.033	0.058
citX; holo-ACP synthase [EC:2.7.7.61]	1.352	0.629	0.033	0.058
clpB; ATP-dependent Clp protease ATP-binding subunit ClpB	1.115	0.553	0.046	0.058
clpP, CLPP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]	1.115	0.553	0.046	0.058
clpX, CLPX; ATP-dependent Clp protease ATP-binding subunit ClpX	1.115	0.553	0.046	0.058
clsA_B; cardiolipin synthase A/B [EC:2.7.8.-]	1.115	0.553	0.046	0.058
cmk; CMP/dCMP kinase [EC:2.7.4.25]	1.115	0.553	0.046	0.058
cmoA; tRNA (cmo5U34)-methyltransferase [EC:2.1.1.-]	1.359	0.653	0.039	0.058
CNP; 2’,3’-cyclic-nucleotide 3’-phosphodiesterase [EC:3.1.4.37]	1.352	0.629	0.033	0.058
coaBC, dfp; phosphopantothenoylcysteine decarboxylase / phosphopantothenate—cysteine ligase [EC:4.1.1.36 6.3.2.5]	1.115	0.553	0.046	0.058
coaE; dephospho-CoA kinase [EC:2.7.1.24]	1.115	0.553	0.046	0.058
coaX; type III pantothenate kinase [EC:2.7.1.33]	1.115	0.553	0.046	0.058
cobA-hemD; uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]	1.115	0.553	0.046	0.058
cobA, btuR; cob(I)alamin adenosyltransferase [EC:2.5.1.17]	1.115	0.553	0.046	0.058
cobB-cbiA; cobyrinic acid a,c-diamide synthase [EC:6.3.5.9 6.3.5.11]	1.115	0.553	0.046	0.058
cobC, phpB; alpha-ribazole phosphatase [EC:3.1.3.73]	1.115	0.553	0.046	0.058
cobD; threonine-phosphate decarboxylase [EC:4.1.1.81]	1.115	0.553	0.046	0.058
cobH-cbiC; precorrin-8X/cobalt-precorrin-8 methylmutase [EC:5.4.99.61 5.4.99.60]	1.115	0.553	0.046	0.058
cobI-cbiL; precorrin-2/cobalt-factor-2 C20-methyltransferase [EC:2.1.1.130 2.1.1.151]	1.115	0.553	0.046	0.058
cobK-cbiJ; precorrin-6A/cobalt-precorrin-6A reductase [EC:1.3.1.54 1.3.1.106]	1.115	0.553	0.046	0.058
cobM, cbiF; precorrin-4/cobalt-precorrin-4 C11-methyltransferase [EC:2.1.1.133 2.1.1.271]	1.115	0.553	0.046	0.058
cobP, cobU; adenosylcobinamide kinase / adenosylcobinamide-phosphate guanylyltransferase [EC:2.7.1.156 2.7.7.62]	1.115	0.553	0.046	0.058
cobQ, cbiP; adenosylcobyric acid synthase [EC:6.3.5.10]	1.115	0.553	0.046	0.058
comB; 2-phosphosulfolactate phosphatase [EC:3.1.3.71]	0.551	0.679	0.419	0.451
comEA; competence protein ComEA	1.115	0.553	0.046	0.058
comEB; dCMP deaminase [EC:3.5.4.12]	1.115	0.553	0.046	0.058
comEC; competence protein ComEC	1.115	0.553	0.046	0.058
comFC; competence protein ComFC	1.115	0.553	0.046	0.058
comM; magnesium chelatase family protein	1.115	0.553	0.046	0.058
copA, ATP7; Cu+-exporting ATPase [EC:3.6.3.54]	1.115	0.553	0.046	0.058
corA; magnesium transporter	1.115	0.553	0.046	0.058
coxS; aerobic carbon-monoxide dehydrogenase small subunit [EC:1.2.5.3]	0.551	0.679	0.419	0.451
cpg; glutamate carboxypeptidase [EC:3.4.17.11]	0.551	0.679	0.419	0.451
crcB, FEX; fluoride exporter	1.219	0.577	0.036	0.058
creD; inner membrane protein	1.115	0.553	0.046	0.058
croR; 3-hydroxybutyryl-CoA dehydratase [EC:4.2.1.55]	0.551	0.679	0.419	0.451
crt; enoyl-CoA hydratase [EC:4.2.1.17]	1.115	0.553	0.046	0.058
csm1, cas10; CRISPR-associated protein Csm1	1.219	0.577	0.036	0.058
csm3; CRISPR-associated protein Csm3	1.219	0.577	0.036	0.058
csm4; CRISPR-associated protein Csm4	1.219	0.577	0.036	0.058
cspA; cold shock protein (beta-ribbon, CspA family)	0.945	0.526	0.074	0.090
cst1, cas8a; CRISPR-associated protein Cst1	1.359	0.653	0.039	0.058
cst2, cas7; CRISPR-associated protein Cst2	1.359	0.653	0.039	0.058
ctpC; manganese/zinc-transporting P-type ATPase C [EC:3.6.3.-]	1.289	0.586	0.029	0.058
cusR, copR, silR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR	1.219	0.577	0.036	0.058
cutC; copper homeostasis protein	1.115	0.553	0.046	0.058
cvpA; membrane protein required for colicin V production	1.115	0.553	0.046	0.058
cvrA, nhaP2; cell volume regulation protein A	1.115	0.553	0.046	0.058
cwlK; peptidoglycan LD-endopeptidase CwlK [EC:3.4.-.-]	0.363	0.518	0.484	0.521
cynT, can; carbonic anhydrase [EC:4.2.1.1]	0.551	0.679	0.419	0.451
cysE; serine O-acetyltransferase [EC:2.3.1.30]	-0.215	0.897	0.811	0.827
cysI; sulfite reductase (NADPH) hemoprotein beta-component [EC:1.8.1.2]	1.219	0.577	0.036	0.058
cysK; cysteine synthase A [EC:2.5.1.47]	1.317	0.596	0.029	0.058
cysS1; cysteinyl-tRNA synthetase, unknown class [EC:6.1.1.16]	1.352	0.629	0.033	0.058
cysZ; CysZ protein	0.551	0.679	0.419	0.451
dacB; serine-type D-Ala-D-Ala carboxypeptidase/endopeptidase (penicillin-binding protein 4) [EC:3.4.16.4 3.4.21.-]	0.551	0.679	0.419	0.451
dacC, dacA, dacD; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]	1.115	0.553	0.046	0.058
dam; DNA adenine methylase [EC:2.1.1.72]	1.352	0.629	0.033	0.058
dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]	1.072	0.542	0.050	0.063
dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	0.087	0.625	0.890	0.893
dapD; 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase [EC:2.3.1.117]	-1.604	1.840	0.385	0.450
dapE; succinyl-diaminopimelate desuccinylase [EC:3.5.1.18]	1.115	0.553	0.046	0.058
dapF; diaminopimelate epimerase [EC:5.1.1.7]	-0.298	0.779	0.702	0.720
dapH, dapD; tetrahydrodipicolinate N-acetyltransferase [EC:2.3.1.89]	-0.298	0.779	0.702	0.720
dctM; C4-dicarboxylate transporter, DctM subunit	1.359	0.653	0.039	0.058
ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]	1.115	0.553	0.046	0.058
deaD, cshA; ATP-dependent RNA helicase DeaD [EC:3.6.4.13]	1.115	0.553	0.046	0.058
deoB; phosphopentomutase [EC:5.4.2.7]	0.551	0.679	0.419	0.451
deoC, DERA; deoxyribose-phosphate aldolase [EC:4.1.2.4]	-0.298	0.779	0.702	0.720
deoD; purine-nucleoside phosphorylase [EC:2.4.2.1]	1.115	0.553	0.046	0.058
dfx; superoxide reductase [EC:1.15.1.2]	-0.298	0.779	0.702	0.720
dgkA, DGK; diacylglycerol kinase (ATP) [EC:2.7.1.107]	-0.298	0.779	0.702	0.720
dhaK; phosphoenolpyruvate—glycerone phosphotransferase subunit DhaK [EC:2.7.1.121]	1.158	0.588	0.051	0.063
dhaL; phosphoenolpyruvate—glycerone phosphotransferase subunit DhaL [EC:2.7.1.121]	1.158	0.588	0.051	0.063
DHFR, folA; dihydrofolate reductase [EC:1.5.1.3]	1.115	0.553	0.046	0.058
dinB; DNA polymerase IV [EC:2.7.7.7]	0.087	0.625	0.890	0.893
dinG; ATP-dependent DNA helicase DinG [EC:3.6.4.12]	1.115	0.553	0.046	0.058
dinJ; DNA-damage-inducible protein J	1.223	0.591	0.040	0.058
disA; diadenylate cyclase [EC:2.7.7.85]	1.115	0.553	0.046	0.058
DLD, lpd, pdhD; dihydrolipoamide dehydrogenase [EC:1.8.1.4]	-1.604	1.840	0.385	0.450
dnaB; replicative DNA helicase [EC:3.6.4.12]	1.115	0.553	0.046	0.058
dnaC; DNA replication protein DnaC	0.551	0.679	0.419	0.451
dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	1.115	0.553	0.046	0.058
dnaG; DNA primase [EC:2.7.7.-]	1.115	0.553	0.046	0.058
dnaJ; molecular chaperone DnaJ	1.115	0.553	0.046	0.058
dnaK, HSPA9; molecular chaperone DnaK	1.115	0.553	0.046	0.058
dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]	1.115	0.553	0.046	0.058
dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]	-0.298	0.779	0.702	0.720
dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]	1.115	0.553	0.046	0.058
DNMT1, dcm; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]	-0.215	0.897	0.811	0.827
DNPEP; aspartyl aminopeptidase [EC:3.4.11.21]	1.158	0.588	0.051	0.063
DOPA; 4,5-DOPA dioxygenase extradiol [EC:1.13.11.-]	1.219	0.577	0.036	0.058
DPM1; dolichol-phosphate mannosyltransferase [EC:2.4.1.83]	1.352	0.629	0.033	0.058
dpo; DNA polymerase bacteriophage-type [EC:2.7.7.7]	1.115	0.553	0.046	0.058
dps; starvation-inducible DNA-binding protein	1.115	0.553	0.046	0.058
DPYS, dht, hydA; dihydropyrimidinase [EC:3.5.2.2]	0.551	0.679	0.419	0.451
dsdA; D-serine dehydratase [EC:4.3.1.18]	1.359	0.653	0.039	0.058
dtd, DTD1; D-tyrosyl-tRNA(Tyr) deacylase [EC:3.1.-.-]	1.115	0.553	0.046	0.058
dut, DUT; dUTP pyrophosphatase [EC:3.6.1.23]	1.115	0.553	0.046	0.058
dxr; 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267]	1.115	0.553	0.046	0.058
dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]	1.136	0.569	0.048	0.061
E1.1.1.3; homoserine dehydrogenase [EC:1.1.1.3]	0.087	0.625	0.890	0.893
E1.17.4.1A, nrdA, nrdE; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]	1.115	0.553	0.046	0.058
E1.17.4.1B, nrdB, nrdF; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1]	1.115	0.553	0.046	0.058
E2.1.1.104; caffeoyl-CoA O-methyltransferase [EC:2.1.1.104]	1.115	0.553	0.046	0.058
E2.1.1.131, cobJ, cbiH; precorrin-3B C17-methyltransferase [EC:2.1.1.131]	1.115	0.553	0.046	0.058
E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	1.115	0.553	0.046	0.058
E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	1.289	0.586	0.029	0.058
E2.2.1.6S, ilvH, ilvN; acetolactate synthase I/III small subunit [EC:2.2.1.6]	0.802	0.500	0.111	0.131
E2.3.1.54, pflD; formate C-acetyltransferase [EC:2.3.1.54]	1.115	0.553	0.046	0.058
E2.3.1.8, pta; phosphate acetyltransferase [EC:2.3.1.8]	1.115	0.553	0.046	0.058
E2.3.1.9, atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]	1.115	0.553	0.046	0.058
E2.4.2.21, cobU, cobT; nicotinate-nucleotide–dimethylbenzimidazole phosphoribosyltransferase [EC:2.4.2.21]	1.115	0.553	0.046	0.058
E2.6.1.-E, patB; aminotransferase [EC:2.6.1.-]	1.219	0.577	0.036	0.058
E2.6.1.42, ilvE; branched-chain amino acid aminotransferase [EC:2.6.1.42]	0.087	0.625	0.890	0.893
E2.7.1.37; protein kinase [EC:2.7.1.37]	1.289	0.586	0.029	0.058
E2.7.1.4, scrK; fructokinase [EC:2.7.1.4]	0.551	0.679	0.419	0.451
E2.7.1.71, aroK, aroL; shikimate kinase [EC:2.7.1.71]	1.115	0.553	0.046	0.058
E2.7.4.8, gmk; guanylate kinase [EC:2.7.4.8]	1.115	0.553	0.046	0.058
E2.7.7.24, rfbA, rffH; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]	-0.298	0.779	0.702	0.720
E2.7.7.3A, coaD, kdtB; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]	1.115	0.553	0.046	0.058
E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	1.136	0.569	0.048	0.061
E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	1.115	0.553	0.046	0.058
E3.1.11.2, xthA; exodeoxyribonuclease III [EC:3.1.11.2]	1.115	0.553	0.046	0.058
E3.1.21.4; type II restriction enzyme [EC:3.1.21.4]	1.219	0.577	0.036	0.058
E3.1.3.15B; histidinol-phosphatase (PHP family) [EC:3.1.3.15]	1.115	0.553	0.046	0.058
E3.1.3.41; 4-nitrophenyl phosphatase [EC:3.1.3.41]	1.352	0.629	0.033	0.058
E3.1.3.97; 3’,5’-nucleoside bisphosphate phosphatase [EC:3.1.3.97]	0.001	0.653	0.999	0.999
E3.1.4.46, glpQ, ugpQ; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46]	1.223	0.582	0.037	0.058
E3.2.1.86B, bglA; 6-phospho-beta-glucosidase [EC:3.2.1.86]	0.551	0.679	0.419	0.451
E3.4.11.-; aminopeptidase [EC:3.4.11.-]	1.115	0.553	0.046	0.058
E3.4.17.19; carboxypeptidase Taq [EC:3.4.17.19]	1.115	0.553	0.046	0.058
E3.4.21.102, prc, ctpA; carboxyl-terminal processing protease [EC:3.4.21.102]	1.115	0.553	0.046	0.058
E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	1.115	0.553	0.046	0.058
E3.5.1.28D, amiD; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	1.289	0.586	0.029	0.058
E3.5.1.81; N-acyl-D-amino-acid deacylase [EC:3.5.1.81]	0.087	0.625	0.890	0.893
E3.6.3.8; Ca2+-transporting ATPase [EC:3.6.3.8]	1.115	0.553	0.046	0.058
E4.1.1.17, ODC1, speC, speF; ornithine decarboxylase [EC:4.1.1.17]	1.289	0.586	0.029	0.058
E4.1.1.49, pckA; phosphoenolpyruvate carboxykinase (ATP) [EC:4.1.1.49]	1.352	0.629	0.033	0.058
E4.1.3.3, nanA, NPL; N-acetylneuraminate lyase [EC:4.1.3.3]	1.115	0.553	0.046	0.058
E4.1.3.4, HMGCL, hmgL; hydroxymethylglutaryl-CoA lyase [EC:4.1.3.4]	1.359	0.653	0.039	0.058
E4.1.99.2; tyrosine phenol-lyase [EC:4.1.99.2]	1.158	0.588	0.051	0.063
E4.2.1.2AA, fumA; fumarate hydratase subunit alpha [EC:4.2.1.2]	-0.298	0.779	0.702	0.720
E4.2.1.2AB, fumB; fumarate hydratase subunit beta [EC:4.2.1.2]	-0.298	0.779	0.702	0.720
E4.2.1.46, rfbB, rffG; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]	1.115	0.553	0.046	0.058
E4.3.1.15; diaminopropionate ammonia-lyase [EC:4.3.1.15]	-0.215	0.897	0.811	0.827
E4.3.1.17, sdaA, sdaB, tdcG; L-serine dehydratase [EC:4.3.1.17]	1.115	0.553	0.046	0.058
E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	1.119	0.539	0.040	0.058
E4.3.1.4; formiminotetrahydrofolate cyclodeaminase [EC:4.3.1.4]	1.355	0.641	0.036	0.058
E4.4.1.11; methionine-gamma-lyase [EC:4.4.1.11]	1.115	0.553	0.046	0.058
E5.2.1.8; peptidylprolyl isomerase [EC:5.2.1.8]	1.319	0.606	0.031	0.058
E6.5.1.2, ligA, ligB; DNA ligase (NAD+) [EC:6.5.1.2]	1.115	0.553	0.046	0.058
EARS, gltX; glutamyl-tRNA synthetase [EC:6.1.1.17]	1.115	0.553	0.046	0.058
ecfA1; energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-]	1.352	0.629	0.033	0.058
ecfA2; energy-coupling factor transport system ATP-binding protein [EC:3.6.3.-]	1.223	0.591	0.040	0.058
ecfT; energy-coupling factor transport system permease protein	1.115	0.553	0.046	0.058
eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42]	-0.298	0.779	0.702	0.720
efp; elongation factor P	1.115	0.553	0.046	0.058
elaA; ElaA protein	0.551	0.679	0.419	0.451
ENDOG; endonuclease G, mitochondrial	1.359	0.653	0.039	0.058
engA, der; GTPase	1.115	0.553	0.046	0.058
engB; GTP-binding protein	1.115	0.553	0.046	0.058
ENO, eno; enolase [EC:4.2.1.11]	1.115	0.553	0.046	0.058
era, ERAL1; GTPase	1.115	0.553	0.046	0.058
eutA; ethanolamine utilization protein EutA	1.352	0.629	0.033	0.058
eutB; ethanolamine ammonia-lyase large subunit [EC:4.3.1.7]	1.352	0.629	0.033	0.058
eutC; ethanolamine ammonia-lyase small subunit [EC:4.3.1.7]	1.352	0.629	0.033	0.058
eutH; ethanolamine transporter	1.158	0.588	0.051	0.063
eutJ; ethanolamine utilization protein EutJ	1.352	0.629	0.033	0.058
eutL; ethanolamine utilization protein EutL	1.352	0.629	0.033	0.058
eutM; ethanolamine utilization protein EutM	1.352	0.629	0.033	0.058
eutN; ethanolamine utilization protein EutN	1.346	0.609	0.029	0.058
eutP; ethanolamine utilization protein EutP	1.352	0.629	0.033	0.058
eutQ; ethanolamine utilization protein EutQ	1.352	0.629	0.033	0.058
eutS; ethanolamine utilization protein EutS	1.352	0.629	0.033	0.058
eutT; ethanolamine utilization cobalamin adenosyltransferase [EC:2.5.1.17]	1.352	0.629	0.033	0.058
exbB; biopolymer transport protein ExbB	1.115	0.553	0.046	0.058
exbD; biopolymer transport protein ExbD	1.115	0.553	0.046	0.058
fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]	1.115	0.553	0.046	0.058
fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]	1.115	0.553	0.046	0.058
fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]	1.115	0.553	0.046	0.058
fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]	1.223	0.582	0.037	0.058
fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9]	1.115	0.553	0.046	0.058
fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]	1.115	0.553	0.046	0.058
fadL; long-chain fatty acid transport protein	1.115	0.553	0.046	0.058
FARSA, pheS; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]	1.115	0.553	0.046	0.058
FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]	1.115	0.553	0.046	0.058
FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	0.001	0.653	0.999	0.999
fbp3; fructose-1,6-bisphosphatase III [EC:3.1.3.11]	1.115	0.553	0.046	0.058
fctD; glutamate formiminotransferase [EC:2.1.2.5]	1.355	0.641	0.036	0.058
feoA; ferrous iron transport protein A	0.551	0.679	0.419	0.451
feoB; ferrous iron transport protein B	0.551	0.679	0.419	0.451
fhaB; filamentous hemagglutinin	1.343	0.625	0.033	0.058
fhs; formate–tetrahydrofolate ligase [EC:6.3.4.3]	1.115	0.553	0.046	0.058
fixA, etfB; electron transfer flavoprotein beta subunit	1.134	0.578	0.051	0.064
fixB, etfA; electron transfer flavoprotein alpha subunit	1.134	0.578	0.051	0.064
fixC; electron transfer flavoprotein-quinone oxidoreductase [EC:1.5.5.-]	1.359	0.653	0.039	0.058
fldA, nifF, isiB; flavodoxin I	1.115	0.553	0.046	0.058
FLOT; flotillin	1.219	0.577	0.036	0.058
fnr; CRP/FNR family transcriptional regulator, anaerobic regulatory protein	1.115	0.553	0.046	0.058
folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]	1.115	0.553	0.046	0.058
folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]	1.115	0.553	0.046	0.058
folP; dihydropteroate synthase [EC:2.5.1.15]	1.115	0.553	0.046	0.058
frdA; fumarate reductase flavoprotein subunit [EC:1.3.5.4]	1.289	0.586	0.029	0.058
frr, MRRF, RRF; ribosome recycling factor	1.115	0.553	0.046	0.058
fruK; 1-phosphofructokinase [EC:2.7.1.56]	1.115	0.553	0.046	0.058
fruR2, fruR; DeoR family transcriptional regulator, fructose operon transcriptional repressor	1.115	0.553	0.046	0.058
FTR, FTH1, efeU; high-affinity iron transporter	1.352	0.629	0.033	0.058
ftsA; cell division protein FtsA	1.115	0.553	0.046	0.058
ftsH, hflB; cell division protease FtsH [EC:3.4.24.-]	1.115	0.553	0.046	0.058
ftsI; cell division protein FtsI (penicillin-binding protein 3) [EC:3.4.16.4]	1.115	0.553	0.046	0.058
ftsQ; cell division protein FtsQ	1.115	0.553	0.046	0.058
ftsW, spoVE; cell division protein FtsW	1.115	0.553	0.046	0.058
ftsX; cell division transport system permease protein	1.115	0.553	0.046	0.058
ftsY; fused signal recognition particle receptor	1.115	0.553	0.046	0.058
ftsZ; cell division protein FtsZ	1.115	0.553	0.046	0.058
fucA; L-fuculose-phosphate aldolase [EC:4.1.2.17]	1.155	0.607	0.059	0.072
fucO; lactaldehyde reductase [EC:1.1.1.77]	1.322	0.616	0.034	0.058
fur, zur, furB; Fur family transcriptional regulator, ferric uptake regulator	1.115	0.553	0.046	0.058
fusA, GFM, EFG; elongation factor G	1.115	0.553	0.046	0.058
fwdE, fmdE; formylmethanofuran dehydrogenase subunit E [EC:1.2.7.12]	1.359	0.653	0.039	0.058
galE, GALE; UDP-glucose 4-epimerase [EC:5.1.3.2]	1.113	0.561	0.049	0.062
galK; galactokinase [EC:2.7.1.6]	1.115	0.553	0.046	0.058
galM, GALM; aldose 1-epimerase [EC:5.1.3.3]	1.115	0.553	0.046	0.058
galT, GALT; UDPglucose–hexose-1-phosphate uridylyltransferase [EC:2.7.7.12]	1.115	0.553	0.046	0.058
GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase [EC:1.2.1.12]	1.115	0.553	0.046	0.058
gatA, QRSL1; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]	1.115	0.553	0.046	0.058
gatB, PET112; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]	1.115	0.553	0.046	0.058
gatC, GATC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]	1.115	0.553	0.046	0.058
GBE1, glgB; 1,4-alpha-glucan branching enzyme [EC:2.4.1.18]	1.115	0.553	0.046	0.058
gcdA; glutaconyl-CoA decarboxylase [EC:4.1.1.70]	1.115	0.553	0.046	0.058
GCH1, folE; GTP cyclohydrolase IA [EC:3.5.4.16]	1.115	0.553	0.046	0.058
gcpE, ispG; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3]	1.115	0.553	0.046	0.058
gctA; glutaconate CoA-transferase, subunit A [EC:2.8.3.12]	1.115	0.553	0.046	0.058
gctB; glutaconate CoA-transferase, subunit B [EC:2.8.3.12]	1.115	0.553	0.046	0.058
gfrE; glucoselysine-6-phosphate deglycase	1.359	0.653	0.039	0.058
gfrF; fructoselysine-6-phosphate deglycase	1.359	0.653	0.039	0.058
GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]	1.115	0.553	0.046	0.058
ggt; gamma-glutamyltranspeptidase / glutathione hydrolase [EC:2.3.2.2 3.4.19.13]	1.359	0.653	0.039	0.058
gidA, mnmG, MTO1; tRNA uridine 5-carboxymethylaminomethyl modification enzyme	1.115	0.553	0.046	0.058
gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]	1.115	0.553	0.046	0.058
glcD; glycolate oxidase [EC:1.1.3.15]	1.359	0.653	0.039	0.058
glgA; starch synthase [EC:2.4.1.21]	1.115	0.553	0.046	0.058
glgC; glucose-1-phosphate adenylyltransferase [EC:2.7.7.27]	1.115	0.553	0.046	0.058
glgX; glycogen debranching enzyme [EC:3.2.1.196]	1.115	0.553	0.046	0.058
glk; glucokinase [EC:2.7.1.2]	1.078	0.528	0.043	0.058
glmE, mutE, mamB; methylaspartate mutase epsilon subunit [EC:5.4.99.1]	1.289	0.586	0.029	0.058
glmM; phosphoglucosamine mutase [EC:5.4.2.10]	1.115	0.553	0.046	0.058
glmS, GFPT; glucosamine—fructose-6-phosphate aminotransferase (isomerizing) [EC:2.6.1.16]	1.115	0.553	0.046	0.058
glmS, mutS, mamA; methylaspartate mutase sigma subunit [EC:5.4.99.1]	1.115	0.553	0.046	0.058
glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / Glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]	1.115	0.553	0.046	0.058
glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	0.087	0.625	0.890	0.893
glnG, ntrC; two-component system, NtrC family, nitrogen regulation response regulator GlnG	1.115	0.553	0.046	0.058
GLO1, gloA; lactoylglutathione lyase [EC:4.4.1.5]	1.223	0.582	0.037	0.058
gloB, HAGH; hydroxyacylglutathione hydrolase [EC:3.1.2.6]	1.115	0.553	0.046	0.058
glpA, glpD; glycerol-3-phosphate dehydrogenase [EC:1.1.5.3]	1.115	0.553	0.046	0.058
GLPF; glycerol uptake facilitator protein	1.115	0.553	0.046	0.058
glpK, GK; glycerol kinase [EC:2.7.1.30]	1.115	0.553	0.046	0.058
glpP; glycerol uptake operon antiterminator	1.115	0.553	0.046	0.058
glpX; fructose-1,6-bisphosphatase II [EC:3.1.3.11]	1.115	0.553	0.046	0.058
glsA, GLS; glutaminase [EC:3.5.1.2]	1.115	0.553	0.046	0.058
gltD; glutamate synthase (NADPH/NADH) small chain [EC:1.4.1.13 1.4.1.14]	-0.298	0.779	0.702	0.720
gltS; glutamate:Na+ symporter, ESS family	1.066	0.545	0.052	0.065
glvA; maltose-6’-phosphate glucosidase [EC:3.2.1.122]	0.551	0.679	0.419	0.451
glxK, garK; glycerate 2-kinase [EC:2.7.1.165]	-0.298	0.779	0.702	0.720
glyA, SHMT; glycine hydroxymethyltransferase [EC:2.1.2.1]	-0.298	0.779	0.702	0.720
glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]	1.115	0.553	0.046	0.058
glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]	1.115	0.553	0.046	0.058
gmhA, lpcA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]	1.115	0.553	0.046	0.058
gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83]	-0.298	0.779	0.702	0.720
gmhD, rfaD; ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]	1.115	0.553	0.046	0.058
GPI, pgi; glucose-6-phosphate isomerase [EC:5.3.1.9]	1.115	0.553	0.046	0.058
gpmB; probable phosphoglycerate mutase [EC:5.4.2.12]	1.115	0.553	0.046	0.058
gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	-0.298	0.779	0.702	0.720
gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]	1.115	0.553	0.046	0.058
gpx; glutathione peroxidase [EC:1.11.1.9]	1.115	0.553	0.046	0.058
groEL, HSPD1; chaperonin GroEL	1.115	0.553	0.046	0.058
groES, HSPE1; chaperonin GroES	1.115	0.553	0.046	0.058
GRPE; molecular chaperone GrpE	1.115	0.553	0.046	0.058
gspD; general secretion pathway protein D	1.115	0.553	0.046	0.058
gspE; general secretion pathway protein E	1.158	0.588	0.051	0.063
gspF; general secretion pathway protein F	1.289	0.586	0.029	0.058
gspG; general secretion pathway protein G	1.115	0.553	0.046	0.058
guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	1.115	0.553	0.046	0.058
gudB, rocG; glutamate dehydrogenase [EC:1.4.1.2]	1.115	0.553	0.046	0.058
gyrA; DNA gyrase subunit A [EC:5.99.1.3]	1.115	0.553	0.046	0.058
gyrB; DNA gyrase subunit B [EC:5.99.1.3]	1.115	0.553	0.046	0.058
HARS, hisS; histidyl-tRNA synthetase [EC:6.1.1.21]	1.115	0.553	0.046	0.058
hcp; hydroxylamine reductase [EC:1.7.99.1]	1.115	0.553	0.046	0.058
hdrA2; heterodisulfide reductase subunit A2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]	0.551	0.679	0.419	0.451
hdrB2; heterodisulfide reductase subunit B2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]	0.551	0.679	0.419	0.451
hdrC2; heterodisulfide reductase subunit C2 [EC:1.8.7.3 1.8.98.4 1.8.98.5 1.8.98.6]	0.551	0.679	0.419	0.451
hemA; glutamyl-tRNA reductase [EC:1.2.1.70]	1.115	0.553	0.046	0.058
hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	1.115	0.553	0.046	0.058
hemC, HMBS; hydroxymethylbilane synthase [EC:2.5.1.61]	1.115	0.553	0.046	0.058
hemK, prmC, HEMK; release factor glutamine methyltransferase [EC:2.1.1.297]	1.115	0.553	0.046	0.058
hemL; glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8]	1.115	0.553	0.046	0.058
hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	1.053	0.541	0.053	0.066
hepST; heptaprenyl diphosphate synthase [EC:2.5.1.30]	1.223	0.591	0.040	0.058
hflX; GTPase	1.115	0.553	0.046	0.058
higB-1; toxin HigB-1	1.352	0.629	0.033	0.058
HINT1, hinT, hit; histidine triad (HIT) family protein	1.115	0.553	0.046	0.058
hipA; serine/threonine-protein kinase HipA [EC:2.7.11.1]	1.359	0.653	0.039	0.058
hipO; hippurate hydrolase [EC:3.5.1.32]	0.551	0.679	0.419	0.451
hlpA, ompH; outer membrane protein	1.115	0.553	0.046	0.058
hlyIII; hemolysin III	1.115	0.553	0.046	0.058
hndA; NADP-reducing hydrogenase subunit HndA [EC:1.12.1.3]	0.551	0.679	0.419	0.451
hndC; NADP-reducing hydrogenase subunit HndC [EC:1.12.1.3]	0.551	0.679	0.419	0.451
hndD; NADP-reducing hydrogenase subunit HndD [EC:1.12.1.3]	0.551	0.679	0.419	0.451
holA; DNA polymerase III subunit delta [EC:2.7.7.7]	1.115	0.553	0.046	0.058
holB; DNA polymerase III subunit delta’ [EC:2.7.7.7]	1.115	0.553	0.046	0.058
hppA; K(+)-stimulated pyrophosphate-energized sodium pump [EC:3.6.1.1]	1.115	0.553	0.046	0.058
hprA; glycerate dehydrogenase [EC:1.1.1.29]	1.289	0.586	0.029	0.058
hprK, ptsK; HPr kinase/phosphorylase [EC:2.7.11.- 2.7.4.-]	1.115	0.553	0.046	0.058
hprT, hpt, HPRT1; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]	1.115	0.553	0.046	0.058
hrcA; heat-inducible transcriptional repressor	1.115	0.553	0.046	0.058
hsdM; type I restriction enzyme M protein [EC:2.1.1.72]	1.119	0.539	0.040	0.058
hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]	1.223	0.582	0.037	0.058
hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]	1.223	0.574	0.035	0.058
hslO; molecular chaperone Hsp33	1.115	0.553	0.046	0.058
hslU; ATP-dependent HslUV protease ATP-binding subunit HslU	0.551	0.679	0.419	0.451
hslV, clpQ; ATP-dependent HslUV protease, peptidase subunit HslV [EC:3.4.25.2]	0.551	0.679	0.419	0.451
HSP90A, htpG; molecular chaperone HtpG	1.115	0.553	0.046	0.058
htpX; heat shock protein HtpX [EC:3.4.24.-]	1.115	0.553	0.046	0.058
hupB; DNA-binding protein HU-beta	0.945	0.526	0.074	0.090
hutG; formiminoglutamase [EC:3.5.3.8]	1.115	0.553	0.046	0.058
hutH, HAL; histidine ammonia-lyase [EC:4.3.1.3]	1.223	0.591	0.040	0.058
hutI, AMDHD1; imidazolonepropionase [EC:3.5.2.7]	1.223	0.591	0.040	0.058
hutU, UROC1; urocanate hydratase [EC:4.2.1.49]	1.223	0.591	0.040	0.058
IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5]	1.115	0.553	0.046	0.058
IDH3; isocitrate dehydrogenase (NAD+) [EC:1.1.1.41]	1.359	0.653	0.039	0.058
idnO; gluconate 5-dehydrogenase [EC:1.1.1.69]	1.359	0.653	0.039	0.058
ilvC; ketol-acid reductoisomerase [EC:1.1.1.86]	0.802	0.500	0.111	0.131
ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	0.802	0.500	0.111	0.131
IMPDH, guaB; IMP dehydrogenase [EC:1.1.1.205]	1.115	0.553	0.046	0.058
infA; translation initiation factor IF-1	1.115	0.553	0.046	0.058
infB, MTIF2; translation initiation factor IF-2	1.115	0.553	0.046	0.058
infC, MTIF3; translation initiation factor IF-3	1.115	0.553	0.046	0.058
INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	0.551	0.679	0.419	0.451
iscS, NFS1; cysteine desulfurase [EC:2.8.1.7]	1.119	0.539	0.040	0.058
iscU, nifU; nitrogen fixation protein NifU and related proteins	1.115	0.553	0.046	0.058
ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60]	1.115	0.553	0.046	0.058
ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148]	1.115	0.553	0.046	0.058
ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12]	1.115	0.553	0.046	0.058
ispH, lytB; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase [EC:1.17.7.4]	1.115	0.553	0.046	0.058
jag; spoIIIJ-associated protein	1.115	0.553	0.046	0.058
K00243; uncharacterized protein	1.115	0.553	0.046	0.058
K00375; GntR family transcriptional regulator / MocR family aminotransferase	1.352	0.629	0.033	0.058
K01138; uncharacterized sulfatase [EC:3.1.6.-]	0.551	0.679	0.419	0.451
K01163; uncharacterized protein	1.115	0.553	0.046	0.058
K01436; amidohydrolase [EC:3.5.1.-]	1.060	0.557	0.059	0.072
K02477; two-component system, LytTR family, response regulator	1.115	0.553	0.046	0.058
K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]	1.115	0.553	0.046	0.058
K02481; two-component system, NtrC family, response regulator	1.289	0.586	0.029	0.058
K03653; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]	1.115	0.553	0.046	0.058
K03710; GntR family transcriptional regulator	0.551	0.679	0.419	0.451
K06867; uncharacterized protein	1.359	0.653	0.039	0.058
K06871; uncharacterized protein	-0.298	0.779	0.702	0.720
K06885; uncharacterized protein	1.158	0.588	0.051	0.063
K06889; uncharacterized protein	1.158	0.588	0.051	0.063
K06890; uncharacterized protein	1.115	0.553	0.046	0.058
K06894; uncharacterized protein	1.115	0.553	0.046	0.058
K06905; uncharacterized protein	1.219	0.577	0.036	0.058
K06906; uncharacterized protein	1.219	0.577	0.036	0.058
K06907; uncharacterized protein	1.219	0.577	0.036	0.058
K06908; uncharacterized protein	1.219	0.577	0.036	0.058
K06915; uncharacterized protein	1.359	0.653	0.039	0.058
K06921; uncharacterized protein	1.352	0.629	0.033	0.058
K06926; uncharacterized protein	1.359	0.653	0.039	0.058
K06960; uncharacterized protein	1.115	0.553	0.046	0.058
K06975; uncharacterized protein	1.115	0.553	0.046	0.058
K07001; NTE family protein	1.078	0.528	0.043	0.058
K07005; uncharacterized protein	1.352	0.629	0.033	0.058
K07006; uncharacterized protein	1.158	0.588	0.051	0.063
K07010; putative glutamine amidotransferase	1.115	0.553	0.046	0.058
K07019; uncharacterized protein	-0.298	0.779	0.702	0.720
K07025; putative hydrolase of the HAD superfamily	0.551	0.679	0.419	0.451
K07030; uncharacterized protein	1.115	0.553	0.046	0.058
K07032; uncharacterized protein	1.359	0.653	0.039	0.058
K07035; uncharacterized protein	1.115	0.553	0.046	0.058
K07037; uncharacterized protein	1.115	0.553	0.046	0.058
K07040; uncharacterized protein	0.551	0.679	0.419	0.451
K07043; uncharacterized protein	1.115	0.553	0.046	0.058
K07052; uncharacterized protein	1.250	0.613	0.043	0.058
K07058; membrane protein	1.115	0.553	0.046	0.058
K07069; uncharacterized protein	1.115	0.553	0.046	0.058
K07082; UPF0755 protein	1.115	0.553	0.046	0.058
K07085; putative transport protein	1.289	0.586	0.029	0.058
K07088; uncharacterized protein	0.970	0.550	0.080	0.096
K07089; uncharacterized protein	0.802	0.500	0.111	0.131
K07090; uncharacterized protein	1.046	0.509	0.042	0.058
K07095; uncharacterized protein	1.078	0.528	0.043	0.058
K07097; uncharacterized protein	1.352	0.629	0.033	0.058
K07098; uncharacterized protein	0.551	0.679	0.419	0.451
K07105; uncharacterized protein	1.115	0.553	0.046	0.058
K07120; uncharacterized protein	1.115	0.553	0.046	0.058
K07124; uncharacterized protein	1.115	0.553	0.046	0.058
K07126; uncharacterized protein	1.219	0.577	0.036	0.058
K07133; uncharacterized protein	1.190	0.584	0.043	0.058
K07137; uncharacterized protein	0.945	0.526	0.074	0.090
K07139; uncharacterized protein	1.115	0.553	0.046	0.058
K07150; uncharacterized protein	1.111	0.570	0.053	0.065
K07160; UPF0271 protein	1.158	0.588	0.051	0.063
K07166; ACT domain-containing protein	-0.298	0.779	0.702	0.720
K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	-0.298	0.779	0.702	0.720
K07318; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	1.359	0.653	0.039	0.058
K07461; putative endonuclease	1.115	0.553	0.046	0.058
K07483; transposase	1.319	0.606	0.031	0.058
K07485; transposase	1.342	0.597	0.026	0.058
K07486; transposase	1.359	0.653	0.039	0.058
K07487; transposase	1.359	0.653	0.039	0.058
K07491; putative transposase	0.087	0.625	0.890	0.893
K07496; putative transposase	0.980	0.465	0.036	0.058
K07497; putative transposase	1.340	0.592	0.025	0.058
K07727; putative transcriptional regulator	0.087	0.625	0.890	0.893
K08303; putative protease [EC:3.4.-.-]	1.115	0.553	0.046	0.058
K08884; serine/threonine protein kinase, bacterial [EC:2.7.11.1]	1.115	0.553	0.046	0.058
K08974; putative membrane protein	1.115	0.553	0.046	0.058
K08998; uncharacterized protein	1.115	0.553	0.046	0.058
K09125; uncharacterized protein	1.115	0.553	0.046	0.058
K09155; uncharacterized protein	1.352	0.629	0.033	0.058
K09157; uncharacterized protein	-0.298	0.779	0.702	0.720
K09729; uncharacterized protein	1.115	0.553	0.046	0.058
K09747; uncharacterized protein	1.115	0.553	0.046	0.058
K09762; uncharacterized protein	1.115	0.553	0.046	0.058
K09769; uncharacterized protein	1.115	0.553	0.046	0.058
K09775; uncharacterized protein	-0.298	0.779	0.702	0.720
K09778; uncharacterized protein	1.115	0.553	0.046	0.058
K09780; uncharacterized protein	1.359	0.653	0.039	0.058
K09787; uncharacterized protein	1.115	0.553	0.046	0.058
K09790; uncharacterized protein	1.115	0.553	0.046	0.058
K09802; uncharacterized protein	1.115	0.553	0.046	0.058
K09858; SEC-C motif domain protein	0.551	0.679	0.419	0.451
K09861; uncharacterized protein	1.115	0.553	0.046	0.058
K09935; uncharacterized protein	1.219	0.577	0.036	0.058
K09949; uncharacterized protein	1.115	0.553	0.046	0.058
K11145; ribonuclease III family protein [EC:3.1.26.-]	1.115	0.553	0.046	0.058
K13653; AraC family transcriptional regulator	1.359	0.653	0.039	0.058
K15024; putative phosphotransacetylase [EC:2.3.1.8]	1.219	0.577	0.036	0.058
KAE1, tsaD, QRI7; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]	1.115	0.553	0.046	0.058
kal; 3-aminobutyryl-CoA ammonia-lyase [EC:4.3.1.14]	1.115	0.553	0.046	0.058
kamA; lysine 2,3-aminomutase [EC:5.4.3.2]	1.115	0.553	0.046	0.058
kamD; beta-lysine 5,6-aminomutase alpha subunit [EC:5.4.3.3]	1.115	0.553	0.046	0.058
kamE; beta-lysine 5,6-aminomutase beta subunit [EC:5.4.3.3]	1.115	0.553	0.046	0.058
KARS, lysS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]	1.115	0.553	0.046	0.058
kce; 3-keto-5-aminohexanoate cleavage enzyme [EC:2.3.1.247]	1.115	0.553	0.046	0.058
kdd; L-erythro-3,5-diaminohexanoate dehydrogenase [EC:1.4.1.11]	1.115	0.553	0.046	0.058
kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45]	-0.298	0.779	0.702	0.720
kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55]	1.115	0.553	0.046	0.058
kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38]	1.115	0.553	0.046	0.058
kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45]	1.115	0.553	0.046	0.058
kdsD, kpsF; arabinose-5-phosphate isomerase [EC:5.3.1.13]	1.115	0.553	0.046	0.058
kduD; 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase [EC:1.1.1.127]	0.551	0.679	0.419	0.451
kduI; 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase [EC:5.3.1.17]	0.551	0.679	0.419	0.451
kptA; putative RNA 2’-phosphotransferase [EC:2.7.1.-]	1.352	0.629	0.033	0.058
ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]	1.115	0.553	0.046	0.058
lacI, galR; LacI family transcriptional regulator	0.001	0.653	0.999	0.999
LARS, leuS; leucyl-tRNA synthetase [EC:6.1.1.4]	1.115	0.553	0.046	0.058
ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]	0.551	0.679	0.419	0.451
LDH, ldh; L-lactate dehydrogenase [EC:1.1.1.27]	1.115	0.553	0.046	0.058
ldhA; D-lactate dehydrogenase [EC:1.1.1.28]	1.115	0.553	0.046	0.058
lemA; LemA protein	1.115	0.553	0.046	0.058
lepA; GTP-binding protein LepA	1.115	0.553	0.046	0.058
lepB; signal peptidase I [EC:3.4.21.89]	1.115	0.553	0.046	0.058
leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	1.219	0.577	0.036	0.058
leuB, IMDH; 3-isopropylmalate dehydrogenase [EC:1.1.1.85]	1.219	0.577	0.036	0.058
leuC, IPMI-L; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]	0.802	0.500	0.111	0.131
leuD, IPMI-S; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]	0.802	0.500	0.111	0.131
lexA; repressor LexA [EC:3.4.21.88]	1.286	0.569	0.025	0.058
lgt, umpA; phosphatidylglycerol:prolipoprotein diacylglycerol transferase [EC:2.-.-.-]	1.115	0.553	0.046	0.058
licD; lipopolysaccharide cholinephosphotransferase [EC:2.7.8.-]	1.352	0.629	0.033	0.058
lip, TGL2; triacylglycerol lipase [EC:3.1.1.3]	1.352	0.629	0.033	0.058
livF; branched-chain amino acid transport system ATP-binding protein	1.115	0.553	0.046	0.058
livG; branched-chain amino acid transport system ATP-binding protein	1.115	0.553	0.046	0.058
livH; branched-chain amino acid transport system permease protein	1.115	0.553	0.046	0.058
livK; branched-chain amino acid transport system substrate-binding protein	1.115	0.553	0.046	0.058
livM; branched-chain amino acid transport system permease protein	1.115	0.553	0.046	0.058
lldG; L-lactate dehydrogenase complex protein LldG	1.359	0.653	0.039	0.058
lolC_E; lipoprotein-releasing system permease protein	1.115	0.553	0.046	0.058
lolD; lipoprotein-releasing system ATP-binding protein [EC:3.6.3.-]	1.115	0.553	0.046	0.058
lon; ATP-dependent Lon protease [EC:3.4.21.53]	1.223	0.591	0.040	0.058
lptB; lipopolysaccharide export system ATP-binding protein [EC:3.6.3.-]	1.115	0.553	0.046	0.058
lptF; lipopolysaccharide export system permease protein	1.115	0.553	0.046	0.058
lptG; lipopolysaccharide export system permease protein	1.115	0.553	0.046	0.058
lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]	1.115	0.553	0.046	0.058
lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]	1.115	0.553	0.046	0.058
lpxC; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [EC:3.5.1.108]	1.115	0.553	0.046	0.058
lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191]	1.223	0.591	0.040	0.058
lpxK; tetraacyldisaccharide 4’-kinase [EC:2.7.1.130]	1.115	0.553	0.046	0.058
lpxL, htrB; Kdo2-lipid IVA lauroyltransferase [EC:2.3.1.241]	1.119	0.539	0.040	0.058
LRA3, yfaW; L-rhamnonate dehydratase [EC:4.2.1.90]	1.359	0.653	0.039	0.058
lspA; signal peptidase II [EC:3.4.23.36]	1.115	0.553	0.046	0.058
ltaE; threonine aldolase [EC:4.1.2.48]	1.115	0.553	0.046	0.058
luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21]	1.219	0.577	0.036	0.058
lysA; diaminopimelate decarboxylase [EC:4.1.1.20]	0.551	0.679	0.419	0.451
lysC; aspartate kinase [EC:2.7.2.4]	0.087	0.625	0.890	0.893
lysE, argO; L-lysine exporter family protein LysE/ArgO	1.115	0.553	0.046	0.058
maf; septum formation protein	1.115	0.553	0.046	0.058
mal; methylaspartate ammonia-lyase [EC:4.3.1.2]	0.551	0.679	0.419	0.451
malQ; 4-alpha-glucanotransferase [EC:2.4.1.25]	1.115	0.553	0.046	0.058
manA, MPI; mannose-6-phosphate isomerase [EC:5.3.1.8]	-0.298	0.779	0.702	0.720
map; methionyl aminopeptidase [EC:3.4.11.18]	1.115	0.553	0.046	0.058
MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]	1.115	0.553	0.046	0.058
mcrB; 5-methylcytosine-specific restriction enzyme B [EC:3.1.21.-]	1.219	0.577	0.036	0.058
mcrC; 5-methylcytosine-specific restriction enzyme subunit McrC	1.219	0.577	0.036	0.058
ME2, sfcA, maeA; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38]	-0.298	0.779	0.702	0.720
menA; 1,4-dihydroxy-2-naphthoate octaprenyltransferase [EC:2.5.1.74 2.5.1.-]	1.359	0.653	0.039	0.058
MET8; precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC:1.3.1.76 4.99.1.4]	1.115	0.553	0.046	0.058
metA; homoserine O-succinyltransferase/O-acetyltransferase [EC:2.3.1.46 2.3.1.31]	1.219	0.577	0.036	0.058
metB; cystathionine gamma-synthase [EC:2.5.1.48]	1.355	0.641	0.036	0.058
metC; cystathionine beta-lyase [EC:4.4.1.8]	1.359	0.653	0.039	0.058
metF, MTHFR; methylenetetrahydrofolate reductase (NADPH) [EC:1.5.1.20]	0.087	0.625	0.890	0.893
metH, MTR; 5-methyltetrahydrofolate–homocysteine methyltransferase [EC:2.1.1.13]	1.115	0.553	0.046	0.058
metI; D-methionine transport system permease protein	1.115	0.553	0.046	0.058
metK; S-adenosylmethionine synthetase [EC:2.5.1.6]	1.115	0.553	0.046	0.058
metN; D-methionine transport system ATP-binding protein	1.115	0.553	0.046	0.058
metQ; D-methionine transport system substrate-binding protein	0.954	0.514	0.065	0.080
metY; O-acetylhomoserine (thiol)-lyase [EC:2.5.1.49]	0.802	0.500	0.111	0.131
mfd; transcription-repair coupling factor (superfamily II helicase) [EC:3.6.4.-]	1.115	0.553	0.046	0.058
mglA; methyl-galactoside transport system ATP-binding protein [EC:3.6.3.17]	1.115	0.553	0.046	0.058
mglB; methyl-galactoside transport system substrate-binding protein	1.115	0.553	0.046	0.058
mglC; methyl-galactoside transport system permease protein	1.115	0.553	0.046	0.058
mgsA; methylglyoxal synthase [EC:4.2.3.3]	0.551	0.679	0.419	0.451
mgtA, mgtB; Mg2+-importing ATPase [EC:3.6.3.2]	-1.604	1.840	0.385	0.450
mgtC; putative Mg2+ transporter-C (MgtC) family protein	1.115	0.553	0.046	0.058
mgtE; magnesium transporter	1.115	0.553	0.046	0.058
miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	1.115	0.553	0.046	0.058
miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]	1.115	0.553	0.046	0.058
minC; septum site-determining protein MinC	1.115	0.553	0.046	0.058
minD; septum site-determining protein MinD	1.115	0.553	0.046	0.058
minE; cell division topological specificity factor	1.115	0.553	0.046	0.058
mipA, ompV; MipA family protein	1.115	0.553	0.046	0.058
mlaA, vacJ; phospholipid-binding lipoprotein MlaA	1.115	0.553	0.046	0.058
MMAB, pduO; cob(I)alamin adenosyltransferase [EC:2.5.1.17]	1.346	0.609	0.029	0.058
mnmA, trmU; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]	1.115	0.553	0.046	0.058
mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-]	1.115	0.553	0.046	0.058
moaA, CNX2; GTP 3’,8-cyclase [EC:4.1.99.22]	0.551	0.679	0.419	0.451
moaC, CNX3; cyclic pyranopterin monophosphate synthase [EC:4.6.1.17]	0.551	0.679	0.419	0.451
mod; adenine-specific DNA-methyltransferase [EC:2.1.1.72]	0.915	0.466	0.051	0.064
modA; molybdate transport system substrate-binding protein	0.551	0.679	0.419	0.451
modB; molybdate transport system permease protein	0.551	0.679	0.419	0.451
motB; chemotaxis protein MotB	1.289	0.586	0.029	0.058
moxR; MoxR-like ATPase [EC:3.6.3.-]	0.551	0.679	0.419	0.451
mraW, rsmH; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]	1.115	0.553	0.046	0.058
mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]	1.115	0.553	0.046	0.058
mrcA; penicillin-binding protein 1A [EC:2.4.1.129 3.4.16.4]	1.115	0.553	0.046	0.058
mrdA; penicillin-binding protein 2 [EC:3.4.16.4]	1.115	0.553	0.046	0.058
mreB; rod shape-determining protein MreB and related proteins	1.115	0.553	0.046	0.058
mreC; rod shape-determining protein MreC	1.115	0.553	0.046	0.058
msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:3.6.3.-]	1.115	0.553	0.046	0.058
mscL; large conductance mechanosensitive channel	1.115	0.553	0.046	0.058
mscS; small conductance mechanosensitive channel	1.078	0.528	0.043	0.058
msmX, msmK, malK, sugC, ggtA, msiK; multiple sugar transport system ATP-binding protein	-0.298	0.779	0.702	0.720
msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12]	1.223	0.582	0.037	0.058
mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5]	1.115	0.553	0.046	0.058
MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9]	1.115	0.553	0.046	0.058
MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]	1.115	0.553	0.046	0.058
mtnA; methylthioribose-1-phosphate isomerase [EC:5.3.1.23]	1.359	0.653	0.039	0.058
mtnK; 5-methylthioribose kinase [EC:2.7.1.100]	1.359	0.653	0.039	0.058
mtnN, mtn, pfs; adenosylhomocysteine nucleosidase [EC:3.2.2.9]	1.115	0.553	0.046	0.058
murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	1.115	0.553	0.046	0.058
murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	1.115	0.553	0.046	0.058
murC; UDP-N-acetylmuramate–alanine ligase [EC:6.3.2.8]	1.115	0.553	0.046	0.058
murD; UDP-N-acetylmuramoylalanine–D-glutamate ligase [EC:6.3.2.9]	1.115	0.553	0.046	0.058
murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate–2,6-diaminopimelate ligase [EC:6.3.2.13]	1.115	0.553	0.046	0.058
murF; UDP-N-acetylmuramoyl-tripeptide–D-alanyl-D-alanine ligase [EC:6.3.2.10]	1.078	0.528	0.043	0.058
murG; UDP-N-acetylglucosamine–N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]	1.115	0.553	0.046	0.058
murI; glutamate racemase [EC:5.1.1.3]	1.083	0.516	0.037	0.058
murJ, mviN; putative peptidoglycan lipid II flippase	1.223	0.582	0.037	0.058
murR; RpiR family transcriptional regulator, murPQ operon repressor	-1.604	1.840	0.385	0.450
mutL; DNA mismatch repair protein MutL	1.115	0.553	0.046	0.058
mutS; DNA mismatch repair protein MutS	1.115	0.553	0.046	0.058
mutS2; DNA mismatch repair protein MutS2	1.115	0.553	0.046	0.058
mutT, NUDT15, MTH2; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]	1.223	0.582	0.037	0.058
nadA; quinolinate synthase [EC:2.5.1.72]	1.115	0.553	0.046	0.058
nadB; L-aspartate oxidase [EC:1.4.3.16]	1.115	0.553	0.046	0.058
nadC, QPRT; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]	1.115	0.553	0.046	0.058
nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]	1.115	0.553	0.046	0.058
nadE; NAD+ synthase [EC:6.3.1.5]	1.115	0.553	0.046	0.058
nagA, AMDHD2; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25]	1.115	0.553	0.046	0.058
nagB, GNPDA; glucosamine-6-phosphate deaminase [EC:3.5.99.6]	1.115	0.553	0.046	0.058
nagC; N-acetylglucosamine repressor	-0.298	0.779	0.702	0.720
nagD; NagD protein	1.158	0.588	0.051	0.063
nanE; N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9]	1.115	0.553	0.046	0.058
NARS, asnS; asparaginyl-tRNA synthetase [EC:6.1.1.22]	1.115	0.553	0.046	0.058
nasT; two-component system, response regulator / RNA-binding antiterminator	1.352	0.629	0.033	0.058
ncd2, npd; nitronate monooxygenase [EC:1.13.12.16]	1.352	0.629	0.033	0.058
nfdA; N-substituted formamide deformylase [EC:3.5.1.91]	1.155	0.607	0.059	0.072
nfo; deoxyribonuclease IV [EC:3.1.21.2]	0.551	0.679	0.419	0.451
nhaC; Na+:H+ antiporter, NhaC family	1.199	0.586	0.042	0.058
nifH; nitrogenase iron protein NifH [EC:1.18.6.1]	1.352	0.629	0.033	0.058
nikA; nickel transport system substrate-binding protein	1.352	0.629	0.033	0.058
nikB; nickel transport system permease protein	1.352	0.629	0.033	0.058
nikC; nickel transport system permease protein	1.352	0.629	0.033	0.058
nikD; nickel transport system ATP-binding protein [EC:3.6.3.24]	1.352	0.629	0.033	0.058
nikE; nickel transport system ATP-binding protein [EC:3.6.3.24]	1.352	0.629	0.033	0.058
nirA; ferredoxin-nitrite reductase [EC:1.7.7.1]	0.551	0.679	0.419	0.451
npdA; NAD-dependent deacetylase [EC:3.5.1.-]	1.123	0.527	0.035	0.058
NQO1; NAD(P)H dehydrogenase (quinone) [EC:1.6.5.2]	1.219	0.577	0.036	0.058
nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4]	1.115	0.553	0.046	0.058
nrdR; transcriptional repressor NrdR	1.115	0.553	0.046	0.058
nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]	1.115	0.553	0.046	0.058
NTH; endonuclease III [EC:4.2.99.18]	1.123	0.527	0.035	0.058
nudF; ADP-ribose pyrophosphatase [EC:3.6.1.13]	1.115	0.553	0.046	0.058
nuoE; NADH-quinone oxidoreductase subunit E [EC:1.6.5.3]	-0.298	0.779	0.702	0.720
nuoF; NADH-quinone oxidoreductase subunit F [EC:1.6.5.3]	0.551	0.679	0.419	0.451
nuoG; NADH-quinone oxidoreductase subunit G [EC:1.6.5.3]	-0.298	0.779	0.702	0.720
nusA; N utilization substance protein A	1.115	0.553	0.046	0.058
nusB; N utilization substance protein B	1.115	0.553	0.046	0.058
nusG; transcriptional antiterminator NusG	1.115	0.553	0.046	0.058
oadA; oxaloacetate decarboxylase, alpha subunit [EC:4.1.1.3]	1.115	0.553	0.046	0.058
oadB; oxaloacetate decarboxylase, beta subunit [EC:4.1.1.3]	1.115	0.553	0.046	0.058
obgE, cgtA; GTPase [EC:3.6.5.-]	1.115	0.553	0.046	0.058
ogt, MGMT; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]	1.115	0.553	0.046	0.058
oppD; oligopeptide transport system ATP-binding protein	1.115	0.553	0.046	0.058
oppF; oligopeptide transport system ATP-binding protein	1.250	0.613	0.043	0.058
opuA; osmoprotectant transport system ATP-binding protein	1.115	0.553	0.046	0.058
opuBD; osmoprotectant transport system permease protein	1.115	0.553	0.046	0.058
oraE; D-ornithine 4,5-aminomutase subunit beta [EC:5.4.3.5]	1.219	0.577	0.036	0.058
oraS; D-ornithine 4,5-aminomutase subunit alpha [EC:5.4.3.5]	1.219	0.577	0.036	0.058
p19, ftrA; periplasmic iron binding protein	1.352	0.629	0.033	0.058
paaH, hbd, fadB, mmgB; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]	1.115	0.553	0.046	0.058
pabA; para-aminobenzoate synthetase component II [EC:2.6.1.85]	1.352	0.629	0.033	0.058
pabB; para-aminobenzoate synthetase component I [EC:2.6.1.85]	1.352	0.629	0.033	0.058
pabC; 4-amino-4-deoxychorismate lyase [EC:4.1.3.38]	1.289	0.586	0.029	0.058
panF; sodium/pantothenate symporter	1.115	0.553	0.046	0.058
parA, soj; chromosome partitioning protein	0.306	0.561	0.586	0.629
PARS, proS; prolyl-tRNA synthetase [EC:6.1.1.15]	1.115	0.553	0.046	0.058
patA; aminotransferase [EC:2.6.1.-]	-0.298	0.779	0.702	0.720
patB, malY; cystathione beta-lyase [EC:4.4.1.8]	1.043	0.542	0.056	0.069
pbpC; penicillin-binding protein 1C [EC:2.4.1.129]	1.115	0.553	0.046	0.058
pbuG; putative MFS transporter, AGZA family, xanthine/uracil permease	1.190	0.588	0.045	0.058
pcp; pyroglutamyl-peptidase [EC:3.4.19.3]	1.115	0.553	0.046	0.058
pct; propionate CoA-transferase [EC:2.8.3.1]	-0.298	0.779	0.702	0.720
PDF, def; peptide deformylase [EC:3.5.1.88]	1.115	0.553	0.046	0.058
pdhR; GntR family transcriptional regulator, transcriptional repressor for pyruvate dehydrogenase complex	0.551	0.679	0.419	0.451
pdtaS; two-component system, sensor histidine kinase PdtaS [EC:2.7.13.3]	1.264	0.602	0.037	0.058
pduC; propanediol dehydratase large subunit [EC:4.2.1.28]	1.219	0.577	0.036	0.058
pduD; propanediol dehydratase medium subunit [EC:4.2.1.28]	1.219	0.577	0.036	0.058
pduE; propanediol dehydratase small subunit [EC:4.2.1.28]	1.219	0.577	0.036	0.058
pduP; propionaldehyde dehydrogenase [EC:1.2.1.87]	1.219	0.577	0.036	0.058
pdxA; 4-hydroxythreonine-4-phosphate dehydrogenase [EC:1.1.1.262]	-0.215	0.897	0.811	0.827
pdxK, pdxY; pyridoxine kinase [EC:2.7.1.35]	-0.298	0.779	0.702	0.720
pdxS, pdx1; pyridoxal 5’-phosphate synthase pdxS subunit [EC:4.3.3.6]	1.115	0.553	0.046	0.058
pdxT, pdx2; 5’-phosphate synthase pdxT subunit [EC:4.3.3.6]	0.551	0.679	0.419	0.451
penP; beta-lactamase class A [EC:3.5.2.6]	1.289	0.586	0.029	0.058
pepD; dipeptidase D [EC:3.4.13.-]	1.264	0.602	0.037	0.058
pepE; dipeptidase E [EC:3.4.13.21]	1.352	0.629	0.033	0.058
pepF, pepB; oligoendopeptidase F [EC:3.4.24.-]	1.115	0.553	0.046	0.058
pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]	1.115	0.553	0.046	0.058
pepQ; Xaa-Pro dipeptidase [EC:3.4.13.9]	1.115	0.553	0.046	0.058
pepT; tripeptide aminopeptidase [EC:3.4.11.4]	1.115	0.553	0.046	0.058
perR; Fur family transcriptional regulator, peroxide stress response regulator	1.115	0.553	0.046	0.058
pezT; UDP-N-acetylglucosamine kinase [EC:2.7.1.176]	1.219	0.577	0.036	0.058
pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]	1.115	0.553	0.046	0.058
pflA, pflC, pflE; pyruvate formate lyase activating enzyme [EC:1.97.1.4]	1.115	0.553	0.046	0.058
PGAM, gpmA; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11]	1.250	0.613	0.043	0.058
PGK, pgk; phosphoglycerate kinase [EC:2.7.2.3]	1.115	0.553	0.046	0.058
pgm; phosphoglucomutase [EC:5.4.2.2]	1.115	0.553	0.046	0.058
pgpA; phosphatidylglycerophosphatase A [EC:3.1.3.27]	1.115	0.553	0.046	0.058
pgsA, PGS1; CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	1.136	0.569	0.048	0.061
pheA; chorismate mutase / prephenate dehydratase [EC:5.4.99.5 4.2.1.51]	0.551	0.679	0.419	0.451
pheB; chorismate mutase [EC:5.4.99.5]	1.115	0.553	0.046	0.058
pheC; cyclohexadienyl dehydratase [EC:4.2.1.51 4.2.1.91]	-1.604	1.840	0.385	0.450
phnC; phosphonate transport system ATP-binding protein [EC:3.6.3.28]	1.352	0.629	0.033	0.058
phnD; phosphonate transport system substrate-binding protein	1.352	0.629	0.033	0.058
phnE; phosphonate transport system permease protein	1.352	0.629	0.033	0.058
phoB1, phoP; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP	-0.298	0.779	0.702	0.720
phoH2; PhoH-like ATPase	-0.298	0.779	0.702	0.720
phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]	-0.298	0.779	0.702	0.720
phoU; phosphate transport system protein	-0.298	0.779	0.702	0.720
pilB; type IV pilus assembly protein PilB	1.115	0.553	0.046	0.058
pilC; type IV pilus assembly protein PilC	1.115	0.553	0.046	0.058
pilD, pppA; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]	1.115	0.553	0.046	0.058
pilT; twitching motility protein PilT	1.115	0.553	0.046	0.058
pip; proline iminopeptidase [EC:3.4.11.5]	1.352	0.629	0.033	0.058
PK, pyk; pyruvate kinase [EC:2.7.1.40]	1.115	0.553	0.046	0.058
plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]	0.551	0.679	0.419	0.451
plsX; glycerol-3-phosphate acyltransferase PlsX [EC:2.3.1.15]	1.115	0.553	0.046	0.058
plsY; glycerol-3-phosphate acyltransferase PlsY [EC:2.3.1.15]	1.115	0.553	0.046	0.058
pncB, NAPRT1; nicotinate phosphoribosyltransferase [EC:6.3.4.21]	1.115	0.553	0.046	0.058
pncC; nicotinamide-nucleotide amidase [EC:3.5.1.42]	1.115	0.553	0.046	0.058
pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]	1.115	0.553	0.046	0.058
polA; DNA polymerase I [EC:2.7.7.7]	1.115	0.553	0.046	0.058
polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]	1.115	0.553	0.046	0.058
por, nifJ; pyruvate-ferredoxin/flavodoxin oxidoreductase [EC:1.2.7.1 1.2.7.-]	1.309	0.625	0.038	0.058
porA; pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]	0.551	0.679	0.419	0.451
porG; pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]	0.551	0.679	0.419	0.451
potA; spermidine/putrescine transport system ATP-binding protein [EC:3.6.3.31]	1.115	0.553	0.046	0.058
potB; spermidine/putrescine transport system permease protein	1.115	0.553	0.046	0.058
potC; spermidine/putrescine transport system permease protein	1.115	0.553	0.046	0.058
potD; spermidine/putrescine transport system substrate-binding protein	1.115	0.553	0.046	0.058
ppa; inorganic pyrophosphatase [EC:3.6.1.1]	1.359	0.653	0.039	0.058
ppaC; manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1]	1.115	0.553	0.046	0.058
ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1]	1.115	0.553	0.046	0.058
pphA; serine/threonine protein phosphatase 1 [EC:3.1.3.16]	1.219	0.577	0.036	0.058
PPIB, ppiB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8]	1.115	0.553	0.046	0.058
ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8]	1.115	0.553	0.046	0.058
ppnK, NADK; NAD+ kinase [EC:2.7.1.23]	1.115	0.553	0.046	0.058
ppnN; pyrimidine/purine-5’-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]	1.352	0.629	0.033	0.058
ppx-gppA; exopolyphosphatase / guanosine-5’-triphosphate,3’-diphosphate pyrophosphatase [EC:3.6.1.11 3.6.1.40]	1.115	0.553	0.046	0.058
PRDX2_4, ahpC; peroxiredoxin (alkyl hydroperoxide reductase subunit C) [EC:1.11.1.15]	1.115	0.553	0.046	0.058
prfA, MTRF1, MRF1; peptide chain release factor 1	1.115	0.553	0.046	0.058
prfB; peptide chain release factor 2	1.115	0.553	0.046	0.058
priA; primosomal protein N’ (replication factor Y) (superfamily II helicase) [EC:3.6.4.-]	1.115	0.553	0.046	0.058
prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]	1.115	0.553	0.046	0.058
proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	0.551	0.679	0.419	0.451
proB; glutamate 5-kinase [EC:2.7.2.11]	0.551	0.679	0.419	0.451
proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]	0.551	0.679	0.419	0.451
PRPS, prsA; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]	1.115	0.553	0.046	0.058
psd, PISD; phosphatidylserine decarboxylase [EC:4.1.1.65]	1.115	0.553	0.046	0.058
pstA; phosphate transport system permease protein	-0.298	0.779	0.702	0.720
pstB; phosphate transport system ATP-binding protein [EC:3.6.3.27]	-0.298	0.779	0.702	0.720
pstC; phosphate transport system permease protein	-1.604	1.840	0.385	0.450
pstS; phosphate transport system substrate-binding protein	-0.298	0.779	0.702	0.720
PTH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]	1.115	0.553	0.046	0.058
PTS-Bgl-EIIC, bglF, bglP; PTS system, beta-glucoside-specific IIC component	1.359	0.653	0.039	0.058
PTS-Cel-EIIA, celC, chbA; PTS system, cellobiose-specific IIA component [EC:2.7.1.196 2.7.1.205]	0.551	0.679	0.419	0.451
PTS-Cel-EIIB, celA, chbB; PTS system, cellobiose-specific IIB component [EC:2.7.1.196 2.7.1.205]	0.551	0.679	0.419	0.451
PTS-Cel-EIIC, celB, chbC; PTS system, cellobiose-specific IIC component	0.551	0.679	0.419	0.451
PTS-Dgl-EIIC, gamP; PTS system, D-glucosamine-specific IIC component	-0.298	0.779	0.702	0.720
PTS-EI.PTSI, ptsI; phosphotransferase system, enzyme I, PtsI [EC:2.7.3.9]	1.078	0.528	0.043	0.058
PTS-Fru-EIIA, fruB; PTS system, fructose-specific IIA component [EC:2.7.1.202]	1.115	0.553	0.046	0.058
PTS-Fru-EIIC, fruA; PTS system, fructose-specific IIC component	0.945	0.526	0.074	0.090
PTS-Fru2-EIIB; PTS system, fructose-specific IIB-like component [EC:2.7.1.-]	-1.604	1.840	0.385	0.450
PTS-Gfr-EIIA, gfrA; PTS system, fructoselysine/glucoselysine-specific IIA component [EC:2.7.1.-]	1.359	0.653	0.039	0.058
PTS-Gfr-EIIB, gfrB; PTS system, fructoselysine/glucoselysine-specific IIB component [EC:2.7.1.-]	1.359	0.653	0.039	0.058
PTS-Gfr-EIIC, gfrC; PTS system, fructoselysine/glucoselysine-specific IIC component	1.359	0.653	0.039	0.058
PTS-Gfr-EIID, gfrD; PTS system, fructoselysine/glucoselysine-specific IID component	1.359	0.653	0.039	0.058
PTS-Glc-EIIA, crr; PTS system, sugar-specific IIA component [EC:2.7.1.-]	1.115	0.553	0.046	0.058
PTS-HPR.PTSH, ptsH; phosphocarrier protein HPr	1.115	0.553	0.046	0.058
PTS-HPR; phosphocarrier protein	1.115	0.553	0.046	0.058
PTS-MalGlc-EIIC, malX; PTS system, maltose/glucose-specific IIC component	0.001	0.653	0.999	0.999
PTS-Nag-EIIC, nagE; PTS system, N-acetylglucosamine-specific IIC component	1.115	0.553	0.046	0.058
PTS-Ntr-EIIA, ptsN; PTS system, nitrogen regulatory IIA component [EC:2.7.1.-]	1.096	0.540	0.044	0.058
PTS-Scr-EIIC, scrA, sacP, sacX, ptsS; PTS system, sucrose-specific IIC component	-0.298	0.779	0.702	0.720
PTS-Ula-EIIA, ulaC, sgaA; PTS system, ascorbate-specific IIA component [EC:2.7.1.194]	-1.604	1.840	0.385	0.450
PTS-Ula-EIIB, ulaB, sgaB; PTS system, ascorbate-specific IIB component [EC:2.7.1.194]	-1.604	1.840	0.385	0.450
PTS-Ula-EIIC, ulaA, sgaT; PTS system, ascorbate-specific IIC component	-1.604	1.840	0.385	0.450
purA, ADSS; adenylosuccinate synthase [EC:6.3.4.4]	1.115	0.553	0.046	0.058
purB, ADSL; adenylosuccinate lyase [EC:4.3.2.2]	1.115	0.553	0.046	0.058
purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]	1.115	0.553	0.046	0.058
purD; phosphoribosylamine—glycine ligase [EC:6.3.4.13]	1.115	0.553	0.046	0.058
purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]	1.115	0.553	0.046	0.058
purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	1.115	0.553	0.046	0.058
purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]	1.115	0.553	0.046	0.058
purL, PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3]	1.115	0.553	0.046	0.058
purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]	1.115	0.553	0.046	0.058
purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2]	1.223	0.591	0.040	0.058
putP; sodium/proline symporter	1.115	0.553	0.046	0.058
PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	1.115	0.553	0.046	0.058
pyrB, PYR2; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]	1.115	0.553	0.046	0.058
pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14]	1.115	0.553	0.046	0.058
pyrDII; dihydroorotate dehydrogenase electron transfer subunit	1.115	0.553	0.046	0.058
pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10]	1.115	0.553	0.046	0.058
pyrF; orotidine-5’-phosphate decarboxylase [EC:4.1.1.23]	1.078	0.528	0.043	0.058
pyrG, CTPS; CTP synthase [EC:6.3.4.2]	0.551	0.679	0.419	0.451
pyrH; uridylate kinase [EC:2.7.4.22]	1.115	0.553	0.046	0.058
pyrP, uraA; uracil permease	1.115	0.553	0.046	0.058
pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9]	1.352	0.629	0.033	0.058
queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]	1.115	0.553	0.046	0.058
queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	0.551	0.679	0.419	0.451
queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]	-0.298	0.779	0.702	0.720
queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]	0.551	0.679	0.419	0.451
queH; epoxyqueuosine reductase [EC:1.17.99.6]	1.115	0.553	0.046	0.058
racD; aspartate racemase [EC:5.1.1.13]	1.219	0.577	0.036	0.058
radA, sms; DNA repair protein RadA/Sms	1.115	0.553	0.046	0.058
radC; DNA repair protein RadC	1.115	0.553	0.046	0.058
rapZ; RNase adapter protein RapZ	1.115	0.553	0.046	0.058
RARS, argS; arginyl-tRNA synthetase [EC:6.1.1.19]	1.115	0.553	0.046	0.058
rbfA; ribosome-binding factor A	1.115	0.553	0.046	0.058
rbgA; ribosome biogenesis GTPase A	1.115	0.553	0.046	0.058
rbsA; ribose transport system ATP-binding protein [EC:3.6.3.17]	0.551	0.679	0.419	0.451
rbsB; ribose transport system substrate-binding protein	0.551	0.679	0.419	0.451
rbsC; ribose transport system permease protein	0.551	0.679	0.419	0.451
rbsD; D-ribose pyranase [EC:5.4.99.62]	0.551	0.679	0.419	0.451
rbsK, RBKS; ribokinase [EC:2.7.1.15]	0.551	0.679	0.419	0.451
rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66]	-0.298	0.779	0.702	0.720
recA; recombination protein RecA	1.115	0.553	0.046	0.058
recF; DNA replication and repair protein RecF	1.115	0.553	0.046	0.058
recG; ATP-dependent DNA helicase RecG [EC:3.6.4.12]	1.129	0.564	0.047	0.060
recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]	1.115	0.553	0.046	0.058
recN; DNA repair protein RecN (Recombination protein N)	1.115	0.553	0.046	0.058
recO; DNA repair protein RecO (recombination protein O)	1.223	0.591	0.040	0.058
recQ; ATP-dependent DNA helicase RecQ [EC:3.6.4.12]	1.115	0.553	0.046	0.058
recR; recombination protein RecR	1.115	0.553	0.046	0.058
recT; recombination protein RecT	-1.604	1.840	0.385	0.450
recX; regulatory protein	1.115	0.553	0.046	0.058
relA; GTP pyrophosphokinase [EC:2.7.6.5]	1.115	0.553	0.046	0.058
relE, stbE; mRNA interferase RelE/StbE	1.282	0.604	0.035	0.058
res; type III restriction enzyme [EC:3.1.21.5]	0.915	0.466	0.051	0.064
rfbC, rmlC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]	1.223	0.582	0.037	0.058
rfbD, rmlD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]	1.078	0.528	0.043	0.058
rho; transcription termination factor Rho	1.115	0.553	0.046	0.058
ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]	1.115	0.553	0.046	0.058
ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]	1.115	0.553	0.046	0.058
ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	1.115	0.553	0.046	0.058
ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]	1.115	0.553	0.046	0.058
ribH, RIB4; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]	1.115	0.553	0.046	0.058
ridA, tdcF, RIDA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10]	1.115	0.553	0.046	0.058
rimI; [ribosomal protein S18]-alanine N-acetyltransferase [EC:2.3.1.266]	1.115	0.553	0.046	0.058
rimJ; [ribosomal protein S5]-alanine N-acetyltransferase [EC:2.3.1.267]	1.355	0.641	0.036	0.058
rimM; 16S rRNA processing protein RimM	1.115	0.553	0.046	0.058
rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4]	-0.298	0.779	0.702	0.720
rimP; ribosome maturation factor RimP	1.115	0.553	0.046	0.058
rlmA1; 23S rRNA (guanine745-N1)-methyltransferase [EC:2.1.1.187]	0.551	0.679	0.419	0.451
rlmB; 23S rRNA (guanosine2251-2’-O)-methyltransferase [EC:2.1.1.185]	1.115	0.553	0.046	0.058
rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177]	1.115	0.553	0.046	0.058
rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191]	1.115	0.553	0.046	0.058
rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]	1.115	0.553	0.046	0.058
rlpA; rare lipoprotein A	-1.604	1.840	0.385	0.450
rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]	1.115	0.553	0.046	0.058
rluC; 23S rRNA pseudouridine955/2504/2580 synthase [EC:5.4.99.24]	1.115	0.553	0.046	0.058
rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]	1.115	0.553	0.046	0.058
rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3]	1.115	0.553	0.046	0.058
rnfA; electron transport complex protein RnfA	1.115	0.553	0.046	0.058
rnfC; electron transport complex protein RnfC	1.115	0.553	0.046	0.058
rnfD; electron transport complex protein RnfD	1.115	0.553	0.046	0.058
rnfE; electron transport complex protein RnfE	1.115	0.553	0.046	0.058
rnfG; electron transport complex protein RnfG	1.115	0.553	0.046	0.058
rng, cafA; ribonuclease G [EC:3.1.26.-]	1.115	0.553	0.046	0.058
rnhA, RNASEH1; ribonuclease HI [EC:3.1.26.4]	0.087	0.625	0.890	0.893
rnhB; ribonuclease HII [EC:3.1.26.4]	1.115	0.553	0.046	0.058
rnj; ribonuclease J [EC:3.1.-.-]	1.119	0.539	0.040	0.058
rnmV; ribonuclease M5 [EC:3.1.26.8]	1.115	0.553	0.046	0.058
rnpA; ribonuclease P protein component [EC:3.1.26.5]	1.115	0.553	0.046	0.058
rnr, vacB; ribonuclease R [EC:3.1.-.-]	1.115	0.553	0.046	0.058
rny; ribonucrease Y [EC:3.1.-.-]	1.115	0.553	0.046	0.058
rocR; arginine utilization regulatory protein	1.219	0.577	0.036	0.058
rodA, mrdB; rod shape determining protein RodA	1.115	0.553	0.046	0.058
RP-L1, MRPL1, rplA; large subunit ribosomal protein L1	1.115	0.553	0.046	0.058
RP-L10, MRPL10, rplJ; large subunit ribosomal protein L10	1.115	0.553	0.046	0.058
RP-L11, MRPL11, rplK; large subunit ribosomal protein L11	1.115	0.553	0.046	0.058
RP-L13, MRPL13, rplM; large subunit ribosomal protein L13	1.115	0.553	0.046	0.058
RP-L14, MRPL14, rplN; large subunit ribosomal protein L14	1.115	0.553	0.046	0.058
RP-L15, MRPL15, rplO; large subunit ribosomal protein L15	1.115	0.553	0.046	0.058
RP-L16, MRPL16, rplP; large subunit ribosomal protein L16	1.115	0.553	0.046	0.058
RP-L17, MRPL17, rplQ; large subunit ribosomal protein L17	1.115	0.553	0.046	0.058
RP-L18, MRPL18, rplR; large subunit ribosomal protein L18	1.115	0.553	0.046	0.058
RP-L19, MRPL19, rplS; large subunit ribosomal protein L19	1.115	0.553	0.046	0.058
RP-L2, MRPL2, rplB; large subunit ribosomal protein L2	1.115	0.553	0.046	0.058
RP-L20, MRPL20, rplT; large subunit ribosomal protein L20	1.115	0.553	0.046	0.058
RP-L21, MRPL21, rplU; large subunit ribosomal protein L21	1.115	0.553	0.046	0.058
RP-L22, MRPL22, rplV; large subunit ribosomal protein L22	1.115	0.553	0.046	0.058
RP-L23, MRPL23, rplW; large subunit ribosomal protein L23	1.115	0.553	0.046	0.058
RP-L24, MRPL24, rplX; large subunit ribosomal protein L24	1.115	0.553	0.046	0.058
RP-L27, MRPL27, rpmA; large subunit ribosomal protein L27	1.115	0.553	0.046	0.058
RP-L28, MRPL28, rpmB; large subunit ribosomal protein L28	1.115	0.553	0.046	0.058
RP-L29, rpmC; large subunit ribosomal protein L29	1.115	0.553	0.046	0.058
RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	1.115	0.553	0.046	0.058
RP-L30, MRPL30, rpmD; large subunit ribosomal protein L30	1.115	0.553	0.046	0.058
RP-L31, rpmE; large subunit ribosomal protein L31	1.115	0.553	0.046	0.058
RP-L32, MRPL32, rpmF; large subunit ribosomal protein L32	1.115	0.553	0.046	0.058
RP-L33, MRPL33, rpmG; large subunit ribosomal protein L33	1.115	0.553	0.046	0.058
RP-L34, MRPL34, rpmH; large subunit ribosomal protein L34	1.115	0.553	0.046	0.058
RP-L35, MRPL35, rpmI; large subunit ribosomal protein L35	1.115	0.553	0.046	0.058
RP-L36, MRPL36, rpmJ; large subunit ribosomal protein L36	1.115	0.553	0.046	0.058
RP-L4, MRPL4, rplD; large subunit ribosomal protein L4	1.115	0.553	0.046	0.058
RP-L5, MRPL5, rplE; large subunit ribosomal protein L5	1.115	0.553	0.046	0.058
RP-L6, MRPL6, rplF; large subunit ribosomal protein L6	1.115	0.553	0.046	0.058
RP-L7, MRPL12, rplL; large subunit ribosomal protein L7/L12	1.115	0.553	0.046	0.058
RP-L9, MRPL9, rplI; large subunit ribosomal protein L9	1.115	0.553	0.046	0.058
RP-S1, rpsA; small subunit ribosomal protein S1	-0.298	0.779	0.702	0.720
RP-S10, MRPS10, rpsJ; small subunit ribosomal protein S10	1.115	0.553	0.046	0.058
RP-S11, MRPS11, rpsK; small subunit ribosomal protein S11	1.115	0.553	0.046	0.058
RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12	1.115	0.553	0.046	0.058
RP-S13, rpsM; small subunit ribosomal protein S13	1.115	0.553	0.046	0.058
RP-S14, MRPS14, rpsN; small subunit ribosomal protein S14	1.115	0.553	0.046	0.058
RP-S15, MRPS15, rpsO; small subunit ribosomal protein S15	1.115	0.553	0.046	0.058
RP-S16, MRPS16, rpsP; small subunit ribosomal protein S16	1.115	0.553	0.046	0.058
RP-S17, MRPS17, rpsQ; small subunit ribosomal protein S17	1.115	0.553	0.046	0.058
RP-S18, MRPS18, rpsR; small subunit ribosomal protein S18	1.115	0.553	0.046	0.058
RP-S19, rpsS; small subunit ribosomal protein S19	1.115	0.553	0.046	0.058
RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2	1.115	0.553	0.046	0.058
RP-S20, rpsT; small subunit ribosomal protein S20	1.115	0.553	0.046	0.058
RP-S3, rpsC; small subunit ribosomal protein S3	1.115	0.553	0.046	0.058
RP-S4, rpsD; small subunit ribosomal protein S4	1.115	0.553	0.046	0.058
RP-S5, MRPS5, rpsE; small subunit ribosomal protein S5	1.115	0.553	0.046	0.058
RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6	1.115	0.553	0.046	0.058
RP-S7, MRPS7, rpsG; small subunit ribosomal protein S7	1.115	0.553	0.046	0.058
RP-S8, rpsH; small subunit ribosomal protein S8	1.115	0.553	0.046	0.058
RP-S9, MRPS9, rpsI; small subunit ribosomal protein S9	1.115	0.553	0.046	0.058
rpe, RPE; ribulose-phosphate 3-epimerase [EC:5.1.3.1]	1.115	0.553	0.046	0.058
rph; ribonuclease PH [EC:2.7.7.56]	-0.298	0.779	0.702	0.720
rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6]	1.115	0.553	0.046	0.058
rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]	1.115	0.553	0.046	0.058
rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]	1.115	0.553	0.046	0.058
rpoC; DNA-directed RNA polymerase subunit beta’ [EC:2.7.7.6]	1.115	0.553	0.046	0.058
rpoD; RNA polymerase primary sigma factor	0.945	0.526	0.074	0.090
rpoE; DNA-directed RNA polymerase subunit delta	0.551	0.679	0.419	0.451
rpoE; RNA polymerase sigma-70 factor, ECF subfamily	1.115	0.553	0.046	0.058
rpoN; RNA polymerase sigma-54 factor	0.087	0.625	0.890	0.893
rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]	1.115	0.553	0.046	0.058
rsbU_P; phosphoserine phosphatase RsbU/P [EC:3.1.3.3]	1.115	0.553	0.046	0.058
rsbV; anti-sigma B factor antagonist	1.115	0.553	0.046	0.058
rsbW; serine/threonine-protein kinase RsbW [EC:2.7.11.1]	1.115	0.553	0.046	0.058
rseC; sigma-E factor negative regulatory protein RseC	1.115	0.553	0.046	0.058
rseP; regulator of sigma E protease [EC:3.4.24.-]	1.115	0.553	0.046	0.058
rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]	1.115	0.553	0.046	0.058
rsmB, sun; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]	1.115	0.553	0.046	0.058
rsmC; 16S rRNA (guanine1207-N2)-methyltransferase [EC:2.1.1.172]	1.115	0.553	0.046	0.058
rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]	1.115	0.553	0.046	0.058
rsmI; 16S rRNA (cytidine1402-2’-O)-methyltransferase [EC:2.1.1.198]	1.115	0.553	0.046	0.058
rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]	1.115	0.553	0.046	0.058
rtpR; ribonucleoside-triphosphate reductase (thioredoxin) [EC:1.17.4.2]	1.115	0.553	0.046	0.058
rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190]	1.115	0.553	0.046	0.058
rusA; crossover junction endodeoxyribonuclease RusA [EC:3.1.22.4]	1.219	0.577	0.036	0.058
ruvA; holliday junction DNA helicase RuvA [EC:3.6.4.12]	1.115	0.553	0.046	0.058
ruvB; holliday junction DNA helicase RuvB [EC:3.6.4.12]	1.115	0.553	0.046	0.058
ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.22.4]	1.115	0.553	0.046	0.058
ruvX; putative holliday junction resolvase [EC:3.1.-.-]	1.115	0.553	0.046	0.058
SAM50, TOB55, bamA; outer membrane protein insertion porin family	1.115	0.553	0.046	0.058
SARS, serS; seryl-tRNA synthetase [EC:6.1.1.11]	1.115	0.553	0.046	0.058
sauS; sulfoacetaldehyde dehydrogenase [EC:1.2.1.81]	1.359	0.653	0.039	0.058
sbcC, rad50; DNA repair protein SbcC/Rad50	1.115	0.553	0.046	0.058
scpA; segregation and condensation protein A	1.115	0.553	0.046	0.058
scpB; segregation and condensation protein B	1.115	0.553	0.046	0.058
sdhA, frdA; succinate dehydrogenase / fumarate reductase, flavoprotein subunit [EC:1.3.5.1 1.3.5.4]	0.551	0.679	0.419	0.451
secA; preprotein translocase subunit SecA	1.115	0.553	0.046	0.058
secB; preprotein translocase subunit SecB	1.219	0.577	0.036	0.058
secD; preprotein translocase subunit SecD	1.115	0.553	0.046	0.058
secE; preprotein translocase subunit SecE	1.115	0.553	0.046	0.058
secF; preprotein translocase subunit SecF	1.115	0.553	0.046	0.058
secG; preprotein translocase subunit SecG	1.115	0.553	0.046	0.058
secY; preprotein translocase subunit SecY	1.115	0.553	0.046	0.058
selA; L-seryl-tRNA(Ser) seleniumtransferase [EC:2.9.1.1]	0.551	0.679	0.419	0.451
selB, EEFSEC; selenocysteine-specific elongation factor	0.551	0.679	0.419	0.451
selD, SEPHS; selenide, water dikinase [EC:2.7.9.3]	0.551	0.679	0.419	0.451
selU; tRNA 2-selenouridine synthase [EC:2.9.1.-]	0.551	0.679	0.419	0.451
sepF; cell division inhibitor SepF	1.198	0.565	0.035	0.058
serA, PHGDH; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]	1.158	0.588	0.051	0.063
sfsA; sugar fermentation stimulation protein A	0.551	0.679	0.419	0.451
sigH; RNA polymerase sporulation-specific sigma factor	1.043	0.542	0.056	0.069
sir; sulfite reductase (ferredoxin) [EC:1.8.7.1]	1.219	0.577	0.036	0.058
slyD; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8]	1.115	0.553	0.046	0.058
smc; chromosome segregation protein	1.115	0.553	0.046	0.058
smf; DNA processing protein	1.136	0.569	0.048	0.061
smpB; SsrA-binding protein	1.115	0.553	0.046	0.058
speG, SAT; diamine N-acetyltransferase [EC:2.3.1.57]	1.359	0.653	0.039	0.058
splB; spore photoproduct lyase [EC:4.1.99.14]	1.115	0.553	0.046	0.058
spmA; spore maturation protein A	0.551	0.679	0.419	0.451
spoIID; stage II sporulation protein D	1.115	0.553	0.046	0.058
spoT; GTP diphosphokinase / guanosine-3’,5’-bis(diphosphate) 3’-diphosphatase [EC:2.7.6.5 3.1.7.2]	1.115	0.553	0.046	0.058
spoU; RNA methyltransferase, TrmH family	1.115	0.553	0.046	0.058
spoVG; stage V sporulation protein G	1.115	0.553	0.046	0.058
SPP; sucrose-6-phosphatase [EC:3.1.3.24]	0.876	0.520	0.094	0.114
sppA; protease IV [EC:3.4.21.-]	1.223	0.582	0.037	0.058
SRP54, ffh; signal recognition particle subunit SRP54 [EC:3.6.5.4]	1.115	0.553	0.046	0.058
ssb; single-strand DNA-binding protein	1.115	0.553	0.046	0.058
ssuA; sulfonate transport system substrate-binding protein	0.087	0.625	0.890	0.893
ssuB; sulfonate transport system ATP-binding protein [EC:3.6.3.-]	0.306	0.561	0.586	0.629
ssuC; sulfonate transport system permease protein	0.087	0.625	0.890	0.893
sulD; dihydroneopterin aldolase / 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:4.1.2.25 2.7.6.3]	1.115	0.553	0.046	0.058
tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]	0.802	0.500	0.111	0.131
tagD; glycerol-3-phosphate cytidylyltransferase [EC:2.7.7.39]	1.115	0.553	0.046	0.058
TARS, thrS; threonyl-tRNA synthetase [EC:6.1.1.3]	1.115	0.553	0.046	0.058
tatD; TatD DNase family protein [EC:3.1.21.-]	1.115	0.553	0.046	0.058
TC.AGCS; alanine or glycine:cation symporter, AGCS family	1.122	0.558	0.046	0.059
TC.APA; basic amino acid/polyamine antiporter, APA family	0.087	0.625	0.890	0.893
TC.BAT1; bacterial/archaeal transporter family protein	0.802	0.500	0.111	0.131
TC.CITMHS; citrate-Mg2+:H+ or citrate-Ca2+:H+ symporter, CitMHS family	1.359	0.653	0.039	0.058
TC.FEV.OM; iron complex outermembrane recepter protein	1.190	0.575	0.040	0.058
TC.GNTP; gluconate:H+ symporter, GntP family	1.223	0.591	0.040	0.058
TC.GPH; glycoside/pentoside/hexuronide:cation symporter, GPH family	1.115	0.553	0.046	0.058
TC.HAE1; hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family	1.078	0.528	0.043	0.058
TC.LIVCS; branched-chain amino acid:cation transporter, LIVCS family	1.115	0.553	0.046	0.058
TC.NCS2; nucleobase:cation symporter-2, NCS2 family	-0.298	0.779	0.702	0.720
TC.NSS; neurotransmitter:Na+ symporter, NSS family	1.115	0.553	0.046	0.058
TC.OMF; outer membrane factor, OMF family	1.115	0.553	0.046	0.058
TC.OOP; OmpA-OmpF porin, OOP family	1.346	0.609	0.029	0.058
TC.SSS; solute:Na+ symporter, SSS family	-0.260	0.801	0.746	0.764
TC.ZIP, zupT, ZRT3, ZIP2; zinc transporter, ZIP family	0.551	0.679	0.419	0.451
tctA; putative tricarboxylic transport membrane protein	1.115	0.553	0.046	0.058
tctB; putative tricarboxylic transport membrane protein	1.158	0.588	0.051	0.063
tex; protein Tex	1.115	0.553	0.046	0.058
tgt, QTRT1; queuine tRNA-ribosyltransferase [EC:2.4.2.29]	1.115	0.553	0.046	0.058
thiB, tbpA; thiamine transport system substrate-binding protein	0.551	0.679	0.419	0.451
thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17]	1.115	0.553	0.046	0.058
thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7]	1.115	0.553	0.046	0.058
thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]	1.223	0.582	0.037	0.058
thiF; sulfur carrier protein ThiS adenylyltransferase [EC:2.7.7.73]	1.115	0.553	0.046	0.058
thiG; thiazole synthase [EC:2.8.1.10]	1.115	0.553	0.046	0.058
thiH; 2-iminoacetate synthase [EC:4.1.99.19]	0.945	0.526	0.074	0.090
thiJ; protein deglycase [EC:3.5.1.124]	1.115	0.553	0.046	0.058
thiN, TPK1, THI80; thiamine pyrophosphokinase [EC:2.7.6.2]	1.115	0.553	0.046	0.058
thiP; thiamine transport system permease protein	0.551	0.679	0.419	0.451
thiS; sulfur carrier protein	1.115	0.553	0.046	0.058
thrB1; homoserine kinase [EC:2.7.1.39]	-0.215	0.897	0.811	0.827
thrB2; homoserine kinase type II [EC:2.7.1.39]	1.289	0.586	0.029	0.058
thrC; threonine synthase [EC:4.2.3.1]	0.087	0.625	0.890	0.893
thyA, TYMS; thymidylate synthase [EC:2.1.1.45]	1.115	0.553	0.046	0.058
tig; trigger factor	1.115	0.553	0.046	0.058
tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]	1.115	0.553	0.046	0.058
tlyA; 23S rRNA (cytidine1920-2’-O)/16S rRNA (cytidine1409-2’-O)-methyltransferase [EC:2.1.1.226 2.1.1.227]	1.115	0.553	0.046	0.058
tlyC; putative hemolysin	1.115	0.553	0.046	0.058
tmk, DTYMK; dTMP kinase [EC:2.7.4.9]	1.115	0.553	0.046	0.058
tnaA; tryptophanase [EC:4.1.99.1]	1.286	0.569	0.025	0.058
tonB; periplasmic protein TonB	1.115	0.553	0.046	0.058
topA; DNA topoisomerase I [EC:5.99.1.2]	1.115	0.553	0.046	0.058
topB; DNA topoisomerase III [EC:5.99.1.2]	1.219	0.577	0.036	0.058
TPI, tpiA; triosephosphate isomerase (TIM) [EC:5.3.1.1]	1.115	0.553	0.046	0.058
trbL; type IV secretion system protein TrbL	1.219	0.577	0.036	0.058
trkA, ktrA; trk system potassium uptake protein	1.115	0.553	0.046	0.058
trkH, trkG, ktrB; trk system potassium uptake protein	1.115	0.553	0.046	0.058
trmB, METTL1; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]	1.078	0.528	0.043	0.058
trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]	1.115	0.553	0.046	0.058
trmFO, gid; methylenetetrahydrofolate–tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]	1.115	0.553	0.046	0.058
trmL, cspR; tRNA (cytidine/uridine-2’-O-)-methyltransferase [EC:2.1.1.207]	1.115	0.553	0.046	0.058
troA, mntA, znuA; manganese/zinc/iron transport system substrate-binding protein	1.352	0.629	0.033	0.058
troB, mntB, znuC; manganese/zinc/iron transport system ATP- binding protein	1.352	0.629	0.033	0.058
troC, mntC, znuB; manganese/zinc/iron transport system permease protein	1.352	0.629	0.033	0.058
troD, mntD, znuB; manganese/zinc/iron transport system permease protein	1.352	0.629	0.033	0.058
trpB; tryptophan synthase beta chain [EC:4.2.1.20]	1.352	0.629	0.033	0.058
truA, PUS1; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]	1.115	0.553	0.046	0.058
truB, PUS4, TRUB1; tRNA pseudouridine55 synthase [EC:5.4.99.25]	1.115	0.553	0.046	0.058
trxA; thioredoxin 1	0.945	0.526	0.074	0.090
trxB, TRR; thioredoxin reductase (NADPH) [EC:1.8.1.9]	1.115	0.553	0.046	0.058
tsaC, rimN, SUA5; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]	1.115	0.553	0.046	0.058
tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE	1.115	0.553	0.046	0.058
tsf, TSFM; elongation factor Ts	1.115	0.553	0.046	0.058
tuf, TUFM; elongation factor Tu	0.970	0.550	0.080	0.096
typA, bipA; GTP-binding protein	1.115	0.553	0.046	0.058
tyrB; aromatic-amino-acid transaminase [EC:2.6.1.57]	1.115	0.553	0.046	0.058
ubiB, aarF; ubiquinone biosynthesis protein	0.551	0.679	0.419	0.451
ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	1.359	0.653	0.039	0.058
udk, UCK; uridine kinase [EC:2.7.1.48]	-0.298	0.779	0.702	0.720
udp, UPP; uridine phosphorylase [EC:2.4.2.3]	-1.604	1.840	0.385	0.450
UGCG; ceramide glucosyltransferase [EC:2.4.1.80]	1.352	0.629	0.033	0.058
UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	0.551	0.679	0.419	0.451
UGP2, galU, galF; UTP–glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]	1.115	0.553	0.046	0.058
UNG, UDG; uracil-DNA glycosylase [EC:3.2.2.27]	1.115	0.553	0.046	0.058
upp, UPRT; uracil phosphoribosyltransferase [EC:2.4.2.9]	1.115	0.553	0.046	0.058
uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]	1.115	0.553	0.046	0.058
URA4, pyrC; dihydroorotase [EC:3.5.2.3]	1.115	0.553	0.046	0.058
urdA; urocanate reductase [EC:1.3.99.33]	0.551	0.679	0.419	0.451
uvrA; excinuclease ABC subunit A	1.115	0.553	0.046	0.058
uvrB; excinuclease ABC subunit B	1.115	0.553	0.046	0.058
uvrC; excinuclease ABC subunit C	1.115	0.553	0.046	0.058
uvrD, pcrA; DNA helicase II / ATP-dependent DNA helicase PcrA [EC:3.6.4.12]	1.096	0.540	0.044	0.058
VARS, valS; valyl-tRNA synthetase [EC:6.1.1.9]	1.115	0.553	0.046	0.058
virB10, lvhB10; type IV secretion system protein VirB10	1.219	0.577	0.036	0.058
virB11, lvhB11; type IV secretion system protein VirB11	1.219	0.577	0.036	0.058
virB4, lvhB4; type IV secretion system protein VirB4	1.219	0.577	0.036	0.058
virB5, lvhB5; type IV secretion system protein VirB5	1.219	0.577	0.036	0.058
virB9, lvhB9; type IV secretion system protein VirB9	1.219	0.577	0.036	0.058
virD4, lvhD4; type IV secretion system protein VirD4	1.219	0.577	0.036	0.058
virK; uncharacterized protein	-0.298	0.779	0.702	0.720
waaF, rfaF; heptosyltransferase II [EC:2.4.-.-]	1.117	0.546	0.042	0.058
waaL, rfaL; O-antigen ligase [EC:2.4.1.-]	1.352	0.629	0.033	0.058
waaY, rfaY; heptose II phosphotransferase [EC:2.7.1.-]	1.198	0.565	0.035	0.058
WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]	1.115	0.553	0.046	0.058
wbjC; UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose reductase [EC:1.1.1.367]	1.219	0.577	0.036	0.058
wbpO; UDP-N-acetyl-D-galactosamine dehydrogenase [EC:1.1.1.-]	1.359	0.653	0.039	0.058
wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolysing) [EC:5.1.3.14]	0.802	0.500	0.111	0.131
xdhC; xanthine dehydrogenase accessory factor	0.551	0.679	0.419	0.451
xerC; integrase/recombinase XerC	0.802	0.500	0.111	0.131
xerD; integrase/recombinase XerD	1.115	0.553	0.046	0.058
xlyAB; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]	1.352	0.629	0.033	0.058
xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22]	-0.298	0.779	0.702	0.720
xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]	1.223	0.582	0.037	0.058
xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]	1.115	0.553	0.046	0.058
xtmA; phage terminase small subunit	-1.604	1.840	0.385	0.450
xtmB; phage terminase large subunit	1.219	0.577	0.036	0.058
yabN; tetrapyrrole methylase family protein / MazG family protein	0.551	0.679	0.419	0.451
yaeR; glyoxylase I family protein	0.551	0.679	0.419	0.451
yajC; preprotein translocase subunit YajC	1.115	0.553	0.046	0.058
YARS, tyrS; tyrosyl-tRNA synthetase [EC:6.1.1.1]	1.115	0.553	0.046	0.058
ybaK, ebsC; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-]	1.115	0.553	0.046	0.058
ybcJ; ribosome-associated protein	1.115	0.553	0.046	0.058
ybeY, yqfG; probable rRNA maturation factor	1.115	0.553	0.046	0.058
ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-]	1.115	0.553	0.046	0.058
ybjD; putative ATP-dependent endonuclease of the OLD family	1.115	0.553	0.046	0.058
ycaJ; putative ATPase	1.115	0.553	0.046	0.058
ycdX; putative hydrolase	0.551	0.679	0.419	0.451
ychF; ribosome-binding ATPase	1.115	0.553	0.046	0.058
yefM; antitoxin YefM	1.219	0.577	0.036	0.058
yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]	1.289	0.586	0.029	0.058
yesN; two-component system, response regulator YesN	1.115	0.553	0.046	0.058
yfbK; Ca-activated chloride channel homolog	1.235	0.555	0.027	0.058
yfiH; polyphenol oxidase [EC:1.10.3.-]	1.115	0.553	0.046	0.058
yggS, PROSC; PLP dependent protein	1.115	0.553	0.046	0.058
yggT; YggT family protein	1.115	0.553	0.046	0.058
yhbH; putative sigma-54 modulation protein	1.115	0.553	0.046	0.058
yhbY; RNA-binding protein	1.115	0.553	0.046	0.058
yidC, spoIIIJ, OXA1, ccfA; YidC/Oxa1 family membrane protein insertase	1.115	0.553	0.046	0.058
yjbB; phosphate:Na+ symporter	1.115	0.553	0.046	0.058
ylxR; uncharacterized protein	1.115	0.553	0.046	0.058
yoeB; toxin YoeB [EC:3.1.-.-]	1.352	0.629	0.033	0.058
ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-]	0.087	0.625	0.890	0.893
yqeH; 30S ribosome assembly GTPase	1.115	0.553	0.046	0.058
yraN; putative endonuclease	1.115	0.553	0.046	0.058
ysxB; uncharacterized protein	1.115	0.553	0.046	0.058
ytmI; uncharacterized N-acetyltransferase [EC:2.3.1.-]	1.264	0.600	0.037	0.058
yuiF; putative amino acid transporter	1.223	0.591	0.040	0.058
zntA; Cd2+/Zn2+-exporting ATPase [EC:3.6.3.3 3.6.3.5]	1.115	0.553	0.046	0.058
znuA; zinc transport system substrate-binding protein	1.136	0.569	0.048	0.061
znuB; zinc transport system permease protein	1.115	0.553	0.046	0.058
znuC; zinc transport system ATP-binding protein [EC:3.6.3.-]	1.115	0.553	0.046	0.058

# merge with tb.ra for full results table
full.res <- left_join(tb.ra, results.out, by = "description")
write.csv(full.res, "output/picrust_ko_stratefied_fuso_data_results.csv", row.names = F)

Session information

sessionInfo()

R version 4.0.5 (2021-03-31)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19042)

Matrix products: default

locale:
[1] LC_COLLATE=English_United States.1252 
[2] LC_CTYPE=English_United States.1252   
[3] LC_MONETARY=English_United States.1252
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.1252    

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] cowplot_1.1.1     dendextend_1.14.0 ggdendro_0.1.22   reshape2_1.4.4   
 [5] car_3.0-10        carData_3.0-4     gvlma_1.0.0.3     patchwork_1.1.1  
 [9] viridis_0.5.1     viridisLite_0.3.0 gridExtra_2.3     xtable_1.8-4     
[13] kableExtra_1.3.4  MASS_7.3-53.1     data.table_1.14.0 readxl_1.3.1     
[17] forcats_0.5.1     stringr_1.4.0     dplyr_1.0.5       purrr_0.3.4      
[21] readr_1.4.0       tidyr_1.1.3       tibble_3.1.0      ggplot2_3.3.3    
[25] tidyverse_1.3.0   lmerTest_3.1-3    lme4_1.1-26       Matrix_1.3-2     
[29] vegan_2.5-7       lattice_0.20-41   permute_0.9-5     phyloseq_1.34.0  
[33] workflowr_1.6.2  

loaded via a namespace (and not attached):
  [1] minqa_1.2.4         colorspace_2.0-0    rio_0.5.26         
  [4] ellipsis_0.3.1      rprojroot_2.0.2     XVector_0.30.0     
  [7] fs_1.5.0            rstudioapi_0.13     farver_2.1.0       
 [10] fansi_0.4.2         lubridate_1.7.10    xml2_1.3.2         
 [13] codetools_0.2-18    splines_4.0.5       knitr_1.31         
 [16] ade4_1.7-16         jsonlite_1.7.2      nloptr_1.2.2.2     
 [19] broom_0.7.5         cluster_2.1.1       dbplyr_2.1.0       
 [22] BiocManager_1.30.10 compiler_4.0.5      httr_1.4.2         
 [25] backports_1.2.1     assertthat_0.2.1    cli_2.3.1          
 [28] later_1.1.0.1       htmltools_0.5.1.1   prettyunits_1.1.1  
 [31] tools_4.0.5         igraph_1.2.6        gtable_0.3.0       
 [34] glue_1.4.2          Rcpp_1.0.6          Biobase_2.50.0     
 [37] cellranger_1.1.0    jquerylib_0.1.3     vctrs_0.3.6        
 [40] Biostrings_2.58.0   rhdf5filters_1.2.0  multtest_2.46.0    
 [43] svglite_2.0.0       ape_5.4-1           nlme_3.1-152       
 [46] iterators_1.0.13    xfun_0.21           ps_1.6.0           
 [49] openxlsx_4.2.3      rvest_1.0.0         lifecycle_1.0.0    
 [52] statmod_1.4.35      zlibbioc_1.36.0     scales_1.1.1       
 [55] hms_1.0.0           promises_1.2.0.1    parallel_4.0.5     
 [58] biomformat_1.18.0   rhdf5_2.34.0        curl_4.3           
 [61] yaml_2.2.1          sass_0.3.1          stringi_1.5.3      
 [64] highr_0.8           S4Vectors_0.28.1    foreach_1.5.1      
 [67] BiocGenerics_0.36.0 zip_2.1.1           boot_1.3-27        
 [70] systemfonts_1.0.1   rlang_0.4.10        pkgconfig_2.0.3    
 [73] evaluate_0.14       Rhdf5lib_1.12.1     labeling_0.4.2     
 [76] tidyselect_1.1.0    plyr_1.8.6          magrittr_2.0.1     
 [79] R6_2.5.0            IRanges_2.24.1      generics_0.1.0     
 [82] DBI_1.1.1           foreign_0.8-81      pillar_1.5.1       
 [85] haven_2.3.1         whisker_0.4         withr_2.4.1        
 [88] mgcv_1.8-34         abind_1.4-5         survival_3.2-10    
 [91] modelr_0.1.8        crayon_1.4.1        utf8_1.1.4         
 [94] rmarkdown_2.7       progress_1.2.2      grid_4.0.5         
 [97] git2r_0.28.0        webshot_0.5.2       reprex_1.0.0       
[100] digest_0.6.27       httpuv_1.5.5        numDeriv_2016.8-1.1
[103] stats4_4.0.5        munsell_0.5.0       bslib_0.2.4