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This page provides the full RSS-NET analysis results of 38 gene
regulatory networks and 18 human complex traits described in Zhu et al
(2021).
Main results
For each phenotype below, please click
to view network enrichment results, click
to view gene prioritization results, and click
to view gene cross-reference results. Please note that loading gene
prioritization results may take a while because of the large number of
genes displayed.
The network enrichment results
()
of each phenotype consist of RSS-NET enrichment Bayes factors of 38 inferred
gene regulatory networks and 1 near-gene control network for the
given trait, and enrichment \(P\)-values of LDSC and Pascal based on the
same networks and GWAS data.
The gene prioritization results
()
of each phenotype consist of RSS-NET posterior probabilities of
association (\(P_1\)) for all network
genes under the baseline (\(M_0\)) and
enrichment (\(M_1\)) models for the
given trait.
The gene cross-reference results
()
of each phenotype consist of external information from Therapeutic
Target Database (TTD), Mouse Genome Informatics (MGI) and Online
Mendelian Inheritance in Man (OMIM).
Phenotype (GWAS publication)
Network enrichment
Gene prioritization
Cross reference
Adult height (Wood et al. 2014)
N/A
Body mass index (Locke et al. 2015)
Waist-to-hip ratio (Shungin et al. 2015)
Breast cancer (Michailidou et al. 2013)
Rheumatoid arthritis (Okada et al. 2014)
Crohn’s disease (Liu et al. 2015)
N/A
Inflammatory bowel disease (Liu et al. 2015)
Ulcerative colitis (Liu et al. 2015)
High-density lipoprotein (Teslovich et al. 2010)
Low-density lipoprotein (Teslovich et al. 2010)
Type 2 diabetes (Morris et al. 2012)
Heart rate (den Hoed et al. 2013)
Coronary artery disease (Nikpay et al. 2015)
Myocardial infarction (Nikpay et al. 2015)
Atrial fibrillation (Christophersen et al. 2017)
Alzheimer’s disease (Lambert et al. 2013)
Schizophrenia (Ripke et al. 2014)
Neuroticism (Okbay et al. 2016)
Additional results
The following pages provide numerical values to reproduce
Supplementary Figures 13 and 14 of Zhu et al
(2021).