Last updated: 2023-01-07

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Knit directory: cirrhosis-metabolism/

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About

In this project I analyze the expression of genes involved in the metabolism of xenobiotic substances in a mouse model that develops chronic liver disease induced by administration of CCl4 for 2, 6 and 12 months [@Holland2021]. In addition I compare their expression in mouse against the expression in patients that suffer from chronic liver disease utilizing a set of publicly patient cohorts with transcriptomic data (see Table 1 in [@Holland2021] for more details)

The focus is on the following gene families: