Last updated: 2022-11-03
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Knit directory: lglasso_data_analysis/
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| File | Version | Author | Date | Message |
|---|---|---|---|---|
| Rmd | b084e20 | Jie Zhou | 2022-10-22 | added output for power_compare1 |
| html | b084e20 | Jie Zhou | 2022-10-22 | added output for power_compare1 |
| Rmd | fb90b17 | Jie Zhou | 2022-10-22 | added output for power_compare1 |
| html | fb90b17 | Jie Zhou | 2022-10-22 | added output for power_compare1 |
| Rmd | 32641ef | Jie Zhou | 2022-10-21 | minor revisions |
| html | 32641ef | Jie Zhou | 2022-10-21 | minor revisions |
| html | 534bd70 | Jie Zhou | 2022-10-21 | minor revisions |
| html | 5246568 | Jie Zhou | 2022-10-21 | updated code for all the figures and tables |
| Rmd | f1fba0a | Jie Zhou | 2022-10-21 | updated code for all the figures and tables |
| html | f1fba0a | Jie Zhou | 2022-10-21 | updated code for all the figures and tables |
| Rmd | 520f495 | Jie Zhou | 2022-10-21 | updated code for all the figures and tables |
| html | 520f495 | Jie Zhou | 2022-10-21 | updated code for all the figures and tables |
| Rmd | e045a4e | Jie Zhou | 2022-09-29 | complete version |
| html | e045a4e | Jie Zhou | 2022-09-29 | complete version |
| Rmd | dd32d09 | Jie Zhou | 2022-09-28 | create the repo |
| html | dd32d09 | Jie Zhou | 2022-09-28 | create the repo |
| html | 4d8e172 | Jie Zhou | 2022-09-27 | Build site. |
| Rmd | 716a0c1 | Jie Zhou | 2022-09-27 | Start workflowr project. |
This website demonstrate the specific procedures to reproduce the results in the paper Identifying Microbial Interaction Networks Based on Irregularly Spaced Longitudinal 16S rRNA sequence data, through which we also show how to use the related R package lgalsso.
In the paper, we compared the proposed network identification algorithm lglasso with other conventional algorithms, i.e., glasso, neighborhood method, GGMselect-CO1 and GGMselect-LA. It is shown that the proposed lglasso outperform the other methods when the data are longitudinal. In order to carry out the simulation studies, in addition to the functions defined in package lglasso, we also defined some other functions to facilitate the simulation. These functions are then sourced into the simulation scripts.
In addition to the simulation studies, we also provide the data and code for reproduce the analysis results for the real data set.
In order to run the script, you need to install the package first, using the following code,
remotes::install_github("jiezhou-2/lglasso",ref = "conditional")
Note since in each figure, there are four scenarios being investigated which only differ in terms of their parameter settings, so only the code for one of the four scenarios are displayed. You can change the parameter setting to get the results for other settings. The same rule is used for the results in the tables. Also since running the code can take hours,if possible, I would suggest to submit the code to a server instead of on your local computer when runing the code.
All the simulation are implemented based on the R function power_compare1, which has the following form result= power_compare1(m,n,p,coe,l,rho,prob,heter,community2,uu,zirate) where
m is the number of subjects to be simulatedn is the number of observations for each subjectp is the number of nodes in the network to be simulatedcoe is the coefficient for the covariate-adjusted lglasso algorithml is the number of replication for the simulationrho is a list with length equal to 5. Each component of rho is a sequence of tuning parameters on which the solution path is computed. These five components correspond to the algorithms lglasso, glasso, nh, GMMselect-C01 and GGMselect-LA respectively.prob is the edge density of the network to be generatedheter is a binary indicator. If heter=0 then generate the data using homogeneous SGGM; if heter=1, then generate the data using heterogeneous SGGM.community2 is a binary indicator. If community2=T, then the data are generated from homogeneous microbial community; if community2=F, then the data are generated from heterogeneous microbial community.uu is a length 2 vector. When community2=T, uu[1] is the correlation parameter for the first community and uu[2] is the correlation parameter for the second community.zirate is a 2-component vector which controls the zero inflation rate in the simulated data.Output result:
result[[1]] is a length 5 list corresponding to the five algorithms. Each of the five components of result[[1]] is a l * 2 matrix. Each row of this matrix is a (TPR, FPR) pair which corresponds to the tuning parameter sequence. The Figures are plotted based on this results.results[[2]] is a 5*2 matrix corresponding to the (TPR, FPR) pairs of the five networks selected by the five algorithms based on EBIC.results[[3]] is a list recording all (TPR, FPR) results of each replicate, each tuning parameter and each algorithms.