Last updated: 2023-12-19

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Knit directory: Cardiotoxicity/

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File Version Author Date Message
Rmd e993745 reneeisnowhere 2023-12-19 Adding pathway enrichment plots
html b442590 reneeisnowhere 2023-11-21 Build site.
Rmd b464f89 reneeisnowhere 2023-11-21 updates to links again
html fd6d33c reneeisnowhere 2023-11-21 Build site.
Rmd cbefbd1 reneeisnowhere 2023-11-21 adding links

library(tidyverse)
library(ggsignif)
library(cowplot)
library(ggpubr)
library(scales)
library(sjmisc)
library(kableExtra)
library(broom)
library(biomaRt)
library(RColorBrewer)
library(gprofiler2)
library(qvalue)
FC_mine <- readRDS("data/toplistall.RDS")
TRZ_list <- FC_mine %>% 
  filter(id=="TRZ",P.Value < 0.05) #%>% 
backGL <- read_csv("data/backGL.txt", 
    col_types = cols(...1 = col_skip()))

TRZ_list3h <- FC_mine %>% 
  filter(id=="TRZ",P.Value < 0.05, time == "3_hours")
TRZ_list24h <- FC_mine %>% 
  filter(id=="TRZ",P.Value < 0.05, time == "24_hours")

TRZ_listqvalue <- FC_mine %>% 
  filter(id=="TRZ", time=="24_hours") %>% 
  dplyr::select(ENTREZID,P.Value)

qobj <- qvalue(TRZ_listqvalue$P.Value)
hist(qobj)

plot(qobj)

TRZ nom de (3 & 24 hour)

# TRZresgenes <- gost(query = TRZ_list$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = TRUE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = backGL$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(TRZresgenes,"data/DEG-GO/TRZresgenes.RDS")
TRZresgenes <- readRDS("data/DEG-GO/TRZresgenes.RDS")

TRZnom <- gostplot(TRZresgenes, capped = FALSE, interactive = TRUE)
TRZnom
TRZnomtable <- TRZresgenes$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

TRZnomtable %>%
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")
source term_id term_name intersection_size term_size p_value
GO:BP GO:1902746 regulation of lens fiber cell differentiation 2 8 6.14e-02
GO:BP GO:0098722 asymmetric stem cell division 1 2 6.14e-02
GO:BP GO:0042078 germ-line stem cell division 1 2 6.14e-02
GO:BP GO:0098728 germline stem cell asymmetric division 1 2 6.14e-02
GO:BP GO:1902747 negative regulation of lens fiber cell differentiation 2 5 6.14e-02
GO:BP GO:0048133 male germ-line stem cell asymmetric division 1 2 6.14e-02
GO:BP GO:0035810 positive regulation of urine volume 2 10 6.14e-02
GO:BP GO:0044849 estrous cycle 2 14 7.09e-02
GO:BP GO:0010801 negative regulation of peptidyl-threonine phosphorylation 2 15 8.54e-02
GO:BP GO:1900745 positive regulation of p38MAPK cascade 2 22 8.66e-02
GO:BP GO:0034599 cellular response to oxidative stress 3 218 8.66e-02
GO:BP GO:1901386 negative regulation of voltage-gated calcium channel activity 2 14 8.66e-02
GO:BP GO:0035809 regulation of urine volume 2 14 8.66e-02
GO:BP GO:0030857 negative regulation of epithelial cell differentiation 2 31 9.28e-02
GO:BP GO:0098708 glucose import across plasma membrane 1 5 9.28e-02
GO:BP GO:0120162 positive regulation of cold-induced thermogenesis 3 72 9.28e-02
GO:BP GO:0098739 import across plasma membrane 3 130 9.28e-02
GO:BP GO:1901020 negative regulation of calcium ion transmembrane transporter activity 2 28 9.28e-02
GO:BP GO:0150104 transport across blood-brain barrier 2 72 9.28e-02
GO:BP GO:0045210 FasL biosynthetic process 1 1 9.28e-02
GO:BP GO:1900744 regulation of p38MAPK cascade 2 32 9.28e-02
GO:BP GO:0098704 carbohydrate import across plasma membrane 1 5 9.28e-02
GO:BP GO:1901385 regulation of voltage-gated calcium channel activity 2 29 9.28e-02
GO:BP GO:0019249 lactate biosynthetic process 1 3 9.28e-02
GO:BP GO:0018345 protein palmitoylation 1 30 9.28e-02
GO:BP GO:0140271 hexose import across plasma membrane 1 5 9.28e-02
GO:BP GO:0097167 circadian regulation of translation 1 4 9.28e-02
GO:BP GO:0051764 actin crosslink formation 1 9 9.28e-02
GO:BP GO:0070306 lens fiber cell differentiation 2 30 9.28e-02
GO:BP GO:0043949 regulation of cAMP-mediated signaling 2 17 9.28e-02
GO:BP GO:0007281 germ cell development 2 194 9.28e-02
GO:BP GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 1 7 9.28e-02
GO:BP GO:0042918 alkanesulfonate transport 1 6 9.28e-02
GO:BP GO:0048762 mesenchymal cell differentiation 4 205 9.28e-02
GO:BP GO:0038066 p38MAPK cascade 2 42 9.28e-02
GO:BP GO:0008356 asymmetric cell division 1 14 9.28e-02
GO:BP GO:0036159 inner dynein arm assembly 1 8 9.28e-02
GO:BP GO:0089718 amino acid import across plasma membrane 2 38 9.28e-02
GO:BP GO:0051939 gamma-aminobutyric acid import 1 3 9.28e-02
GO:BP GO:0051946 regulation of glutamate uptake involved in transmission of nerve impulse 1 3 9.28e-02
GO:BP GO:0060251 regulation of glial cell proliferation 1 26 9.28e-02
GO:BP GO:0060252 positive regulation of glial cell proliferation 1 14 9.28e-02
GO:BP GO:0010719 negative regulation of epithelial to mesenchymal transition 2 29 9.28e-02
GO:BP GO:0006979 response to oxidative stress 3 328 9.28e-02
GO:BP GO:0060485 mesenchyme development 4 250 9.28e-02
GO:BP GO:0061643 chemorepulsion of axon 1 6 9.28e-02
GO:BP GO:0062197 cellular response to chemical stress 3 269 9.28e-02
GO:BP GO:0051941 regulation of amino acid uptake involved in synaptic transmission 1 3 9.28e-02
GO:BP GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 1 21 9.28e-02
GO:BP GO:0022412 cellular process involved in reproduction in multicellular organism 2 255 9.28e-02
GO:BP GO:1904059 regulation of locomotor rhythm 1 3 9.28e-02
GO:BP GO:0010232 vascular transport 2 72 9.28e-02
GO:BP GO:1990708 conditioned place preference 1 2 9.28e-02
GO:BP GO:0015734 taurine transport 1 6 9.28e-02
GO:BP GO:1904350 regulation of protein catabolic process in the vacuole 1 13 9.28e-02
GO:BP GO:2001258 negative regulation of cation channel activity 2 31 9.28e-02
GO:BP GO:0014015 positive regulation of gliogenesis 1 44 9.28e-02
GO:BP GO:0001837 epithelial to mesenchymal transition 3 139 9.28e-02
GO:BP GO:0014009 glial cell proliferation 1 40 9.28e-02
GO:BP GO:1905165 regulation of lysosomal protein catabolic process 1 11 9.28e-02
GO:BP GO:1903170 negative regulation of calcium ion transmembrane transport 2 35 9.28e-02
GO:BP GO:0015757 galactose transmembrane transport 1 4 9.28e-02
GO:BP GO:1904351 negative regulation of protein catabolic process in the vacuole 1 5 9.28e-02
GO:BP GO:1902966 positive regulation of protein localization to early endosome 1 10 9.28e-02
GO:BP GO:1902965 regulation of protein localization to early endosome 1 10 9.28e-02
GO:BP GO:0017145 stem cell division 1 25 9.28e-02
GO:BP GO:1902946 protein localization to early endosome 1 12 9.28e-02
GO:BP GO:0003018 vascular process in circulatory system 3 198 9.28e-02
GO:BP GO:0010799 regulation of peptidyl-threonine phosphorylation 2 35 9.28e-02
GO:BP GO:0015800 acidic amino acid transport 2 39 9.28e-02
GO:BP GO:0018230 peptidyl-L-cysteine S-palmitoylation 1 21 9.28e-02
GO:BP GO:1905166 negative regulation of lysosomal protein catabolic process 1 5 9.28e-02
GO:BP GO:0120161 regulation of cold-induced thermogenesis 3 115 9.49e-02
GO:BP GO:0045226 extracellular polysaccharide biosynthetic process 1 2 9.49e-02
GO:BP GO:1905668 positive regulation of protein localization to endosome 1 14 9.49e-02
GO:BP GO:1900625 positive regulation of monocyte aggregation 1 3 9.49e-02
GO:BP GO:0048232 male gamete generation 2 346 9.49e-02
GO:BP GO:0046379 extracellular polysaccharide metabolic process 1 2 9.49e-02
GO:BP GO:0007283 spermatogenesis 2 333 9.49e-02
GO:BP GO:0007288 sperm axoneme assembly 1 20 9.49e-02
GO:BP GO:1905666 regulation of protein localization to endosome 1 15 9.49e-02
GO:BP GO:1900623 regulation of monocyte aggregation 1 3 9.49e-02
GO:BP GO:0106106 cold-induced thermogenesis 3 116 9.54e-02
GO:BP GO:0070345 negative regulation of fat cell proliferation 1 4 9.57e-02
GO:BP GO:0045666 positive regulation of neuron differentiation 1 63 9.57e-02
GO:BP GO:0018198 peptidyl-cysteine modification 1 41 9.57e-02
GO:BP GO:0000379 tRNA-type intron splice site recognition and cleavage 1 3 9.96e-02
GO:BP GO:0014013 regulation of gliogenesis 1 66 9.96e-02
GO:BP GO:0003013 circulatory system process 4 445 1.04e-01
GO:BP GO:0006044 N-acetylglucosamine metabolic process 1 16 1.04e-01
GO:BP GO:0000271 polysaccharide biosynthetic process 2 54 1.04e-01
GO:BP GO:0019933 cAMP-mediated signaling 2 35 1.04e-01
GO:BP GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway 1 3 1.04e-01
GO:BP GO:1900127 positive regulation of hyaluronan biosynthetic process 1 4 1.04e-01
GO:BP GO:1990845 adaptive thermogenesis 3 127 1.04e-01
GO:BP GO:0003333 amino acid transmembrane transport 2 70 1.04e-01
GO:BP GO:0015812 gamma-aminobutyric acid transport 1 11 1.04e-01
GO:BP GO:0120316 sperm flagellum assembly 1 27 1.04e-01
GO:BP GO:0070286 axonemal dynein complex assembly 1 21 1.04e-01
GO:BP GO:0051935 glutamate reuptake 1 4 1.04e-01
GO:BP GO:0070837 dehydroascorbic acid transport 1 7 1.04e-01
GO:BP GO:0090500 endocardial cushion to mesenchymal transition 1 4 1.04e-01
GO:BP GO:0032328 alanine transport 1 13 1.04e-01
GO:BP GO:1905146 lysosomal protein catabolic process 1 19 1.04e-01
GO:BP GO:0051926 negative regulation of calcium ion transport 2 45 1.05e-01
GO:BP GO:0007276 gamete generation 2 465 1.05e-01
GO:BP GO:0003351 epithelial cilium movement involved in extracellular fluid movement 1 30 1.05e-01
GO:BP GO:0070373 negative regulation of ERK1 and ERK2 cascade 2 58 1.05e-01
GO:BP GO:0034089 establishment of meiotic sister chromatid cohesion 1 4 1.05e-01
GO:BP GO:0007039 protein catabolic process in the vacuole 1 22 1.07e-01
GO:BP GO:0046330 positive regulation of JNK cascade 2 71 1.07e-01
GO:BP GO:0006858 extracellular transport 1 33 1.07e-01
GO:BP GO:0019852 L-ascorbic acid metabolic process 1 10 1.07e-01
GO:BP GO:1901334 lactone metabolic process 1 10 1.07e-01
GO:BP GO:0060437 lung growth 1 4 1.07e-01
GO:BP GO:0042752 regulation of circadian rhythm 2 93 1.07e-01
GO:BP GO:0010887 negative regulation of cholesterol storage 1 8 1.07e-01
GO:BP GO:1901071 glucosamine-containing compound metabolic process 1 19 1.08e-01
GO:BP GO:0070487 monocyte aggregation 1 4 1.08e-01
GO:BP GO:0002036 regulation of L-glutamate import across plasma membrane 1 6 1.08e-01
GO:BP GO:0042698 ovulation cycle 2 54 1.08e-01
GO:BP GO:1901842 negative regulation of high voltage-gated calcium channel activity 1 4 1.09e-01
GO:BP GO:0001659 temperature homeostasis 3 135 1.09e-01
GO:BP GO:0036010 protein localization to endosome 1 28 1.16e-01
GO:BP GO:0032413 negative regulation of ion transmembrane transporter activity 2 52 1.17e-01
GO:BP GO:0048609 multicellular organismal reproductive process 2 538 1.17e-01
GO:BP GO:0106072 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1 8 1.20e-01
GO:BP GO:0070295 renal water absorption 1 6 1.20e-01
GO:BP GO:0031397 negative regulation of protein ubiquitination 2 76 1.22e-01
GO:BP GO:0051933 amino acid neurotransmitter reuptake 1 5 1.24e-01
GO:BP GO:0070344 regulation of fat cell proliferation 1 8 1.24e-01
GO:BP GO:0032504 multicellular organism reproduction 2 558 1.25e-01
GO:BP GO:0006497 protein lipidation 1 89 1.25e-01
GO:BP GO:0038003 G protein-coupled opioid receptor signaling pathway 1 5 1.25e-01
GO:BP GO:0044458 motile cilium assembly 1 46 1.25e-01
GO:BP GO:0031400 negative regulation of protein modification process 4 396 1.26e-01
GO:BP GO:0050767 regulation of neurogenesis 3 302 1.26e-01
GO:BP GO:0042158 lipoprotein biosynthetic process 1 92 1.26e-01
GO:BP GO:0032410 negative regulation of transporter activity 2 59 1.26e-01
GO:BP GO:0003006 developmental process involved in reproduction 2 603 1.26e-01
GO:BP GO:0045664 regulation of neuron differentiation 1 137 1.26e-01
GO:BP GO:1900125 regulation of hyaluronan biosynthetic process 1 6 1.26e-01
GO:BP GO:0060449 bud elongation involved in lung branching 1 7 1.26e-01
GO:BP GO:0002088 lens development in camera-type eye 2 57 1.27e-01
GO:BP GO:0043951 negative regulation of cAMP-mediated signaling 1 10 1.33e-01
GO:BP GO:0051382 kinetochore assembly 1 17 1.33e-01
GO:BP GO:0042754 negative regulation of circadian rhythm 1 8 1.33e-01
GO:BP GO:0050769 positive regulation of neurogenesis 1 190 1.33e-01
GO:BP GO:0019953 sexual reproduction 2 633 1.33e-01
GO:BP GO:1904063 negative regulation of cation transmembrane transport 2 64 1.33e-01
GO:BP GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 2 85 1.33e-01
GO:BP GO:0032874 positive regulation of stress-activated MAPK cascade 2 95 1.33e-01
GO:BP GO:0106070 regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1 11 1.33e-01
GO:BP GO:0006865 amino acid transport 2 103 1.33e-01
GO:BP GO:1903321 negative regulation of protein modification by small protein conjugation or removal 2 86 1.33e-01
GO:BP GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 2 97 1.35e-01
GO:BP GO:0006040 amino sugar metabolic process 1 34 1.36e-01
GO:BP GO:0016202 regulation of striated muscle tissue development 1 13 1.36e-01
GO:BP GO:0010885 regulation of cholesterol storage 1 13 1.36e-01
GO:BP GO:0010717 regulation of epithelial to mesenchymal transition 2 87 1.36e-01
GO:BP GO:1905039 carboxylic acid transmembrane transport 2 111 1.36e-01
GO:BP GO:1903825 organic acid transmembrane transport 2 112 1.37e-01
GO:BP GO:0003097 renal water transport 1 7 1.39e-01
GO:BP GO:0045596 negative regulation of cell differentiation 5 471 1.39e-01
GO:BP GO:0070341 fat cell proliferation 1 11 1.39e-01
GO:BP GO:1901019 regulation of calcium ion transmembrane transporter activity 2 70 1.39e-01
GO:BP GO:0045475 locomotor rhythm 1 13 1.39e-01
GO:BP GO:0005976 polysaccharide metabolic process 2 81 1.39e-01
GO:BP GO:0019935 cyclic-nucleotide-mediated signaling 2 52 1.39e-01
GO:BP GO:0042157 lipoprotein metabolic process 1 116 1.40e-01
GO:BP GO:0034766 negative regulation of monoatomic ion transmembrane transport 2 70 1.40e-01
GO:BP GO:0051962 positive regulation of nervous system development 1 222 1.41e-01
GO:BP GO:0051383 kinetochore organization 1 21 1.41e-01
GO:BP GO:0000226 microtubule cytoskeleton organization 2 549 1.41e-01
GO:BP GO:0046328 regulation of JNK cascade 2 113 1.41e-01
GO:BP GO:0015711 organic anion transport 3 270 1.41e-01
GO:BP GO:0045662 negative regulation of myoblast differentiation 1 20 1.41e-01
GO:BP GO:0035082 axoneme assembly 1 54 1.41e-01
GO:BP GO:0010958 regulation of amino acid import across plasma membrane 1 14 1.42e-01
GO:BP GO:0051960 regulation of nervous system development 4 357 1.42e-01
GO:BP GO:1903789 regulation of amino acid transmembrane transport 1 14 1.42e-01
GO:BP GO:0018107 peptidyl-threonine phosphorylation 2 96 1.42e-01
GO:BP GO:1901874 negative regulation of post-translational protein modification 2 98 1.45e-01
GO:BP GO:0050435 amyloid-beta metabolic process 1 48 1.45e-01
GO:BP GO:0010888 negative regulation of lipid storage 1 15 1.47e-01
GO:BP GO:0098712 L-glutamate import across plasma membrane 1 11 1.47e-01
GO:BP GO:0048634 regulation of muscle organ development 1 14 1.47e-01
GO:BP GO:0034085 establishment of sister chromatid cohesion 1 10 1.49e-01
GO:BP GO:0060349 bone morphogenesis 2 74 1.50e-01
GO:BP GO:0048843 negative regulation of axon extension involved in axon guidance 1 26 1.50e-01
GO:BP GO:0042063 gliogenesis 1 244 1.51e-01
GO:BP GO:0050872 white fat cell differentiation 1 15 1.51e-01
GO:BP GO:0051386 regulation of neurotrophin TRK receptor signaling pathway 1 11 1.52e-01
GO:BP GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway 1 8 1.52e-01
GO:BP GO:0045595 regulation of cell differentiation 8 1122 1.52e-01
GO:BP GO:0010878 cholesterol storage 1 18 1.52e-01
GO:BP GO:0051580 regulation of neurotransmitter uptake 1 15 1.53e-01
GO:BP GO:0018210 peptidyl-threonine modification 2 103 1.53e-01
GO:BP GO:2000678 negative regulation of transcription regulatory region DNA binding 1 17 1.53e-01
GO:BP GO:0051549 positive regulation of keratinocyte migration 1 11 1.53e-01
GO:BP GO:0072348 sulfur compound transport 1 36 1.54e-01
GO:BP GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 1 33 1.57e-01
GO:BP GO:0001933 negative regulation of protein phosphorylation 3 265 1.57e-01
GO:BP GO:0006089 lactate metabolic process 1 16 1.57e-01
GO:BP GO:0048511 rhythmic process 3 233 1.57e-01
GO:BP GO:0001578 microtubule bundle formation 1 79 1.57e-01
GO:BP GO:0070486 leukocyte aggregation 1 9 1.58e-01
GO:BP GO:0030213 hyaluronan biosynthetic process 1 10 1.58e-01
GO:BP GO:0036302 atrioventricular canal development 1 12 1.58e-01
GO:BP GO:1901841 regulation of high voltage-gated calcium channel activity 1 12 1.62e-01
GO:BP GO:0003014 renal system process 2 76 1.62e-01
GO:BP GO:0015804 neutral amino acid transport 1 43 1.62e-01
GO:BP GO:0048841 regulation of axon extension involved in axon guidance 1 31 1.62e-01
GO:BP GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus 1 10 1.62e-01
GO:BP GO:0043543 protein acylation 1 193 1.62e-01
GO:BP GO:0010838 positive regulation of keratinocyte proliferation 1 9 1.62e-01
GO:BP GO:0097722 sperm motility 1 62 1.62e-01
GO:BP GO:0034508 centromere complex assembly 1 29 1.62e-01
GO:BP GO:0051547 regulation of keratinocyte migration 1 13 1.62e-01
GO:BP GO:0030317 flagellated sperm motility 1 62 1.62e-01
GO:BP GO:0043065 positive regulation of apoptotic process 4 394 1.63e-01
GO:BP GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 1 30 1.65e-01
GO:BP GO:0007254 JNK cascade 2 137 1.65e-01
GO:BP GO:0006836 neurotransmitter transport 2 141 1.65e-01
GO:BP GO:0043620 regulation of DNA-templated transcription in response to stress 1 38 1.65e-01
GO:BP GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation 1 13 1.65e-01
GO:BP GO:0006487 protein N-linked glycosylation 1 65 1.65e-01
GO:BP GO:0010720 positive regulation of cell development 1 318 1.65e-01
GO:BP GO:0007623 circadian rhythm 2 160 1.65e-01
GO:BP GO:0060294 cilium movement involved in cell motility 1 69 1.65e-01
GO:BP GO:0001539 cilium or flagellum-dependent cell motility 1 72 1.66e-01
GO:BP GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation 1 14 1.66e-01
GO:BP GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 2 126 1.66e-01
GO:BP GO:0043153 entrainment of circadian clock by photoperiod 1 23 1.66e-01
GO:BP GO:0043068 positive regulation of programmed cell death 4 403 1.66e-01
GO:BP GO:0048846 axon extension involved in axon guidance 1 35 1.66e-01
GO:BP GO:0042326 negative regulation of phosphorylation 3 290 1.66e-01
GO:BP GO:1902284 neuron projection extension involved in neuron projection guidance 1 35 1.66e-01
GO:BP GO:0051177 meiotic sister chromatid cohesion 1 11 1.66e-01
GO:BP GO:1901201 regulation of extracellular matrix assembly 1 15 1.66e-01
GO:BP GO:0034763 negative regulation of transmembrane transport 2 96 1.66e-01
GO:BP GO:0021591 ventricular system development 1 29 1.66e-01
GO:BP GO:0022414 reproductive process 2 924 1.66e-01
GO:BP GO:0055012 ventricular cardiac muscle cell differentiation 1 15 1.66e-01
GO:BP GO:0043271 negative regulation of monoatomic ion transport 2 88 1.66e-01
GO:BP GO:0060285 cilium-dependent cell motility 1 72 1.66e-01
GO:BP GO:0000003 reproduction 2 933 1.66e-01
GO:BP GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 2 127 1.68e-01
GO:BP GO:0009648 photoperiodism 1 24 1.73e-01
GO:BP GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 1 16 1.73e-01
GO:BP GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 2 122 1.73e-01
GO:BP GO:0032872 regulation of stress-activated MAPK cascade 2 153 1.73e-01
GO:BP GO:0001822 kidney development 3 246 1.74e-01
GO:BP GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 1 16 1.74e-01
GO:BP GO:0070302 regulation of stress-activated protein kinase signaling cascade 2 157 1.78e-01
GO:BP GO:0071526 semaphorin-plexin signaling pathway 1 44 1.78e-01
GO:BP GO:0090181 regulation of cholesterol metabolic process 1 27 1.79e-01
GO:BP GO:0009649 entrainment of circadian clock 1 27 1.79e-01
GO:BP GO:0015813 L-glutamate transmembrane transport 1 18 1.79e-01
GO:BP GO:0050919 negative chemotaxis 1 42 1.82e-01
GO:BP GO:0030517 negative regulation of axon extension 1 41 1.82e-01
GO:BP GO:0072001 renal system development 3 253 1.82e-01
GO:BP GO:2001257 regulation of cation channel activity 2 100 1.83e-01
GO:BP GO:0030856 regulation of epithelial cell differentiation 2 100 1.83e-01
GO:BP GO:0060602 branch elongation of an epithelium 1 15 1.84e-01
GO:BP GO:0007017 microtubule-based process 2 757 1.84e-01
GO:BP GO:0051546 keratinocyte migration 1 15 1.86e-01
GO:BP GO:0071498 cellular response to fluid shear stress 1 19 1.86e-01
GO:BP GO:0043950 positive regulation of cAMP-mediated signaling 1 5 1.86e-01
GO:BP GO:0003341 cilium movement 1 97 1.86e-01
GO:BP GO:0010874 regulation of cholesterol efflux 1 31 1.86e-01
GO:BP GO:0003417 growth plate cartilage development 1 14 1.88e-01
GO:BP GO:0030010 establishment of cell polarity 2 135 1.88e-01
GO:BP GO:0007286 spermatid development 1 108 1.88e-01
GO:BP GO:0071174 mitotic spindle checkpoint signaling 1 43 1.91e-01
GO:BP GO:0007094 mitotic spindle assembly checkpoint signaling 1 43 1.91e-01
GO:BP GO:0036120 cellular response to platelet-derived growth factor stimulus 1 20 1.91e-01
GO:BP GO:0071173 spindle assembly checkpoint signaling 1 43 1.91e-01
GO:BP GO:0048515 spermatid differentiation 1 114 1.91e-01
GO:BP GO:0099111 microtubule-based transport 1 192 1.92e-01
GO:BP GO:0045841 negative regulation of mitotic metaphase/anaphase transition 1 45 1.92e-01
GO:BP GO:0009988 cell-cell recognition 1 31 1.92e-01
GO:BP GO:1900746 regulation of vascular endothelial growth factor signaling pathway 1 18 1.92e-01
GO:BP GO:0098810 neurotransmitter reuptake 1 21 1.92e-01
GO:BP GO:0031577 spindle checkpoint signaling 1 44 1.92e-01
GO:BP GO:1901861 regulation of muscle tissue development 1 34 1.92e-01
GO:BP GO:0033046 negative regulation of sister chromatid segregation 1 45 1.92e-01
GO:BP GO:0051180 vitamin transport 1 29 1.92e-01
GO:BP GO:0042755 eating behavior 1 16 1.92e-01
GO:BP GO:0033048 negative regulation of mitotic sister chromatid segregation 1 45 1.92e-01
GO:BP GO:2000816 negative regulation of mitotic sister chromatid separation 1 45 1.92e-01
GO:BP GO:0051301 cell division 1 569 1.93e-01
GO:BP GO:0042177 negative regulation of protein catabolic process 1 100 1.93e-01
GO:BP GO:0051938 L-glutamate import 1 24 1.94e-01
GO:BP GO:1905819 negative regulation of chromosome separation 1 46 1.94e-01
GO:BP GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 1 46 1.94e-01
GO:BP GO:0051985 negative regulation of chromosome segregation 1 46 1.94e-01
GO:BP GO:2000647 negative regulation of stem cell proliferation 1 18 1.94e-01
GO:BP GO:0007517 muscle organ development 2 279 1.94e-01
GO:BP GO:0036119 response to platelet-derived growth factor 1 22 1.94e-01
GO:BP GO:0010563 negative regulation of phosphorus metabolic process 3 335 1.94e-01
GO:BP GO:0021756 striatum development 1 18 1.94e-01
GO:BP GO:0005996 monosaccharide metabolic process 2 212 1.94e-01
GO:BP GO:0045936 negative regulation of phosphate metabolic process 3 334 1.94e-01
GO:BP GO:0043409 negative regulation of MAPK cascade 2 145 1.94e-01
GO:BP GO:0048011 neurotrophin TRK receptor signaling pathway 1 23 1.94e-01
GO:BP GO:0001755 neural crest cell migration 1 49 1.94e-01
GO:BP GO:1905953 negative regulation of lipid localization 1 31 1.94e-01
GO:BP GO:0006612 protein targeting to membrane 1 120 1.94e-01
GO:BP GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 1 20 1.94e-01
GO:BP GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 2 71 1.94e-01
GO:BP GO:0003091 renal water homeostasis 1 14 1.94e-01
GO:BP GO:0043408 regulation of MAPK cascade 4 473 1.94e-01
GO:BP GO:0090497 mesenchymal cell migration 1 51 1.95e-01
GO:BP GO:0033047 regulation of mitotic sister chromatid segregation 1 51 1.97e-01
GO:BP GO:0051783 regulation of nuclear division 2 115 1.97e-01
GO:BP GO:0050922 negative regulation of chemotaxis 1 44 1.97e-01
GO:BP GO:0035265 organ growth 2 128 1.98e-01
GO:BP GO:0048512 circadian behavior 1 30 1.98e-01
GO:BP GO:0051248 negative regulation of protein metabolic process 5 799 1.98e-01
GO:BP GO:0051403 stress-activated MAPK cascade 2 188 1.99e-01
GO:BP GO:0006767 water-soluble vitamin metabolic process 1 50 1.99e-01
GO:BP GO:0045839 negative regulation of mitotic nuclear division 1 53 2.00e-01
GO:BP GO:0010883 regulation of lipid storage 1 38 2.02e-01
GO:BP GO:0007622 rhythmic behavior 1 32 2.03e-01
GO:BP GO:0007130 synaptonemal complex assembly 1 10 2.03e-01
GO:BP GO:0032331 negative regulation of chondrocyte differentiation 1 18 2.04e-01
GO:BP GO:0050771 negative regulation of axonogenesis 1 59 2.05e-01
GO:BP GO:0010965 regulation of mitotic sister chromatid separation 1 56 2.06e-01
GO:BP GO:0045661 regulation of myoblast differentiation 1 60 2.06e-01
GO:BP GO:0051955 regulation of amino acid transport 1 28 2.06e-01
GO:BP GO:0031098 stress-activated protein kinase signaling cascade 2 194 2.06e-01
GO:BP GO:0031345 negative regulation of cell projection organization 2 154 2.10e-01
GO:BP GO:0034260 negative regulation of GTPase activity 1 25 2.10e-01
GO:BP GO:0006833 water transport 1 12 2.11e-01
GO:BP GO:0001504 neurotransmitter uptake 1 29 2.11e-01
GO:BP GO:0009250 glucan biosynthetic process 1 40 2.11e-01
GO:BP GO:0060441 epithelial tube branching involved in lung morphogenesis 1 21 2.11e-01
GO:BP GO:0051784 negative regulation of nuclear division 1 56 2.11e-01
GO:BP GO:0051306 mitotic sister chromatid separation 1 59 2.11e-01
GO:BP GO:1901798 positive regulation of signal transduction by p53 class mediator 1 28 2.11e-01
GO:BP GO:0005978 glycogen biosynthetic process 1 40 2.11e-01
GO:BP GO:0060284 regulation of cell development 1 593 2.11e-01
GO:BP GO:0045776 negative regulation of blood pressure 1 30 2.11e-01
GO:BP GO:0051093 negative regulation of developmental process 5 654 2.11e-01
GO:BP GO:0045597 positive regulation of cell differentiation 1 618 2.11e-01
GO:BP GO:0044092 negative regulation of molecular function 5 730 2.12e-01
GO:BP GO:0003416 endochondral bone growth 1 22 2.12e-01
GO:BP GO:1903169 regulation of calcium ion transmembrane transport 2 120 2.12e-01
GO:BP GO:0033344 cholesterol efflux 1 41 2.12e-01
GO:BP GO:0070193 synaptonemal complex organization 1 13 2.12e-01
GO:BP GO:0021544 subpallium development 1 19 2.12e-01
GO:BP GO:0003401 axis elongation 1 25 2.12e-01
GO:BP GO:0035116 embryonic hindlimb morphogenesis 1 17 2.12e-01
GO:BP GO:0090162 establishment of epithelial cell polarity 1 30 2.13e-01
GO:BP GO:0050890 cognition 2 226 2.13e-01
GO:BP GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 1 36 2.14e-01
GO:BP GO:0070293 renal absorption 1 24 2.15e-01
GO:BP GO:0043392 negative regulation of DNA binding 1 44 2.15e-01
GO:BP GO:0006469 negative regulation of protein kinase activity 2 173 2.15e-01
GO:BP GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 1 25 2.15e-01
GO:BP GO:0046323 glucose import 1 55 2.18e-01
GO:BP GO:0001654 eye development 3 273 2.19e-01
GO:BP GO:0061037 negative regulation of cartilage development 1 23 2.20e-01
GO:BP GO:0060317 cardiac epithelial to mesenchymal transition 1 28 2.20e-01
GO:BP GO:0030212 hyaluronan metabolic process 1 21 2.20e-01
GO:BP GO:0007179 transforming growth factor beta receptor signaling pathway 2 177 2.20e-01
GO:BP GO:0014032 neural crest cell development 1 70 2.20e-01
GO:BP GO:0150063 visual system development 3 274 2.20e-01
GO:BP GO:0032371 regulation of sterol transport 1 45 2.20e-01
GO:BP GO:0032374 regulation of cholesterol transport 1 45 2.20e-01
GO:BP GO:2000677 regulation of transcription regulatory region DNA binding 1 43 2.20e-01
GO:BP GO:0050891 multicellular organismal-level water homeostasis 1 17 2.20e-01
GO:BP GO:0098868 bone growth 1 23 2.20e-01
GO:BP GO:0048880 sensory system development 3 276 2.24e-01
GO:BP GO:0090150 establishment of protein localization to membrane 1 258 2.24e-01
GO:BP GO:0000122 negative regulation of transcription by RNA polymerase II 1 744 2.24e-01
GO:BP GO:0034405 response to fluid shear stress 1 31 2.24e-01
GO:BP GO:1905818 regulation of chromosome separation 1 69 2.24e-01
GO:BP GO:0048864 stem cell development 1 75 2.29e-01
GO:BP GO:0048384 retinoic acid receptor signaling pathway 1 27 2.29e-01
GO:BP GO:0048566 embryonic digestive tract development 1 20 2.29e-01
GO:BP GO:0000132 establishment of mitotic spindle orientation 1 32 2.32e-01
GO:BP GO:0032885 regulation of polysaccharide biosynthetic process 1 32 2.32e-01
GO:BP GO:0031396 regulation of protein ubiquitination 2 194 2.32e-01
GO:BP GO:0060351 cartilage development involved in endochondral bone morphogenesis 1 25 2.33e-01
GO:BP GO:0016051 carbohydrate biosynthetic process 2 160 2.33e-01
GO:BP GO:0000165 MAPK cascade 4 553 2.34e-01
GO:BP GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 1 36 2.35e-01
GO:BP GO:0006605 protein targeting 1 310 2.36e-01
GO:BP GO:0038179 neurotrophin signaling pathway 1 36 2.36e-01
GO:BP GO:0002931 response to ischemia 1 48 2.36e-01
GO:BP GO:0060271 cilium assembly 1 296 2.36e-01
GO:BP GO:0042044 fluid transport 1 19 2.36e-01
GO:BP GO:0014033 neural crest cell differentiation 1 79 2.36e-01
GO:BP GO:0051304 chromosome separation 1 75 2.36e-01
GO:BP GO:0048048 embryonic eye morphogenesis 1 25 2.36e-01
GO:BP GO:0030516 regulation of axon extension 1 82 2.36e-01
GO:BP GO:0007267 cell-cell signaling 5 1150 2.36e-01
GO:BP GO:0033673 negative regulation of kinase activity 2 191 2.36e-01
GO:BP GO:0043410 positive regulation of MAPK cascade 3 316 2.36e-01
GO:BP GO:0002068 glandular epithelial cell development 1 28 2.36e-01
GO:BP GO:0035137 hindlimb morphogenesis 1 21 2.36e-01
GO:BP GO:0040020 regulation of meiotic nuclear division 1 19 2.36e-01
GO:BP GO:0003008 system process 6 1194 2.38e-01
GO:BP GO:0014911 positive regulation of smooth muscle cell migration 1 32 2.38e-01
GO:BP GO:0046942 carboxylic acid transport 2 213 2.39e-01
GO:BP GO:0140013 meiotic nuclear division 2 117 2.39e-01
GO:BP GO:0098916 anterograde trans-synaptic signaling 2 490 2.39e-01
GO:BP GO:0007268 chemical synaptic transmission 2 490 2.39e-01
GO:BP GO:0015849 organic acid transport 2 214 2.39e-01
GO:BP GO:0019229 regulation of vasoconstriction 1 38 2.40e-01
GO:BP GO:0099537 trans-synaptic signaling 2 494 2.41e-01
GO:BP GO:0045445 myoblast differentiation 1 90 2.43e-01
GO:BP GO:0044782 cilium organization 1 317 2.43e-01
GO:BP GO:0007163 establishment or maintenance of cell polarity 2 197 2.43e-01
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 9 1832 2.45e-01
GO:BP GO:0032881 regulation of polysaccharide metabolic process 1 35 2.45e-01
GO:BP GO:0085029 extracellular matrix assembly 1 36 2.45e-01
GO:BP GO:0038084 vascular endothelial growth factor signaling pathway 1 35 2.45e-01
GO:BP GO:0040001 establishment of mitotic spindle localization 1 37 2.45e-01
GO:BP GO:0030071 regulation of mitotic metaphase/anaphase transition 1 87 2.45e-01
GO:BP GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 1 37 2.45e-01
GO:BP GO:0090311 regulation of protein deacetylation 1 44 2.46e-01
GO:BP GO:0035725 sodium ion transmembrane transport 1 112 2.46e-01
GO:BP GO:0051294 establishment of spindle orientation 1 37 2.46e-01
GO:BP GO:0099536 synaptic signaling 2 512 2.46e-01
GO:BP GO:0007018 microtubule-based movement 1 300 2.46e-01
GO:BP GO:0007010 cytoskeleton organization 2 1186 2.48e-01
GO:BP GO:0051310 metaphase chromosome alignment 1 87 2.48e-01
GO:BP GO:0045944 positive regulation of transcription by RNA polymerase II 1 918 2.48e-01
GO:BP GO:1902099 regulation of metaphase/anaphase transition of cell cycle 1 88 2.48e-01
GO:BP GO:1902475 L-alpha-amino acid transmembrane transport 1 51 2.48e-01
GO:BP GO:0048640 negative regulation of developmental growth 1 94 2.48e-01
GO:BP GO:0008284 positive regulation of cell population proliferation 1 886 2.48e-01
GO:BP GO:0007091 metaphase/anaphase transition of mitotic cell cycle 1 91 2.48e-01
GO:BP GO:0060348 bone development 2 157 2.48e-01
GO:BP GO:0050793 regulation of developmental process 5 1813 2.48e-01
GO:BP GO:0061387 regulation of extent of cell growth 1 96 2.48e-01
GO:BP GO:2001251 negative regulation of chromosome organization 1 89 2.48e-01
GO:BP GO:0032922 circadian regulation of gene expression 1 63 2.48e-01
GO:BP GO:0050795 regulation of behavior 1 41 2.50e-01
GO:BP GO:0010837 regulation of keratinocyte proliferation 1 33 2.50e-01
GO:BP GO:0044784 metaphase/anaphase transition of cell cycle 1 92 2.51e-01
GO:BP GO:0045892 negative regulation of DNA-templated transcription 1 1005 2.52e-01
GO:BP GO:0051094 positive regulation of developmental process 1 957 2.52e-01
GO:BP GO:0006486 protein glycosylation 1 185 2.52e-01
GO:BP GO:0043413 macromolecule glycosylation 1 185 2.52e-01
GO:BP GO:0060560 developmental growth involved in morphogenesis 2 207 2.52e-01
GO:BP GO:0046580 negative regulation of Ras protein signal transduction 1 46 2.53e-01
GO:BP GO:0042632 cholesterol homeostasis 1 58 2.53e-01
GO:BP GO:0044042 glucan metabolic process 1 65 2.53e-01
GO:BP GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 1 37 2.53e-01
GO:BP GO:0007264 small GTPase mediated signal transduction 3 413 2.53e-01
GO:BP GO:0008037 cell recognition 1 82 2.53e-01
GO:BP GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 2 211 2.53e-01
GO:BP GO:1902533 positive regulation of intracellular signal transduction 5 707 2.53e-01
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 1 1014 2.53e-01
GO:BP GO:0055092 sterol homeostasis 1 59 2.53e-01
GO:BP GO:0005977 glycogen metabolic process 1 64 2.53e-01
GO:BP GO:1903046 meiotic cell cycle process 2 132 2.53e-01
GO:BP GO:0019915 lipid storage 1 68 2.53e-01
GO:BP GO:0019233 sensory perception of pain 1 39 2.53e-01
GO:BP GO:0051726 regulation of cell cycle 4 941 2.53e-01
GO:BP GO:1902532 negative regulation of intracellular signal transduction 3 445 2.53e-01
GO:BP GO:0031641 regulation of myelination 1 35 2.53e-01
GO:BP GO:1903320 regulation of protein modification by small protein conjugation or removal 2 232 2.53e-01
GO:BP GO:0010389 regulation of G2/M transition of mitotic cell cycle 1 94 2.53e-01
GO:BP GO:0006766 vitamin metabolic process 1 75 2.53e-01
GO:BP GO:0000280 nuclear division 3 343 2.53e-01
GO:BP GO:0033045 regulation of sister chromatid segregation 1 99 2.53e-01
GO:BP GO:2000026 regulation of multicellular organismal development 1 997 2.53e-01
GO:BP GO:0070085 glycosylation 1 197 2.53e-01
GO:BP GO:1904659 glucose transmembrane transport 1 84 2.53e-01
GO:BP GO:0032890 regulation of organic acid transport 1 48 2.53e-01
GO:BP GO:0030182 neuron differentiation 1 1058 2.53e-01
GO:BP GO:0051303 establishment of chromosome localization 1 93 2.54e-01
GO:BP GO:0048705 skeletal system morphogenesis 2 155 2.54e-01
GO:BP GO:0071560 cellular response to transforming growth factor beta stimulus 2 222 2.54e-01
GO:BP GO:0051348 negative regulation of transferase activity 2 225 2.54e-01
GO:BP GO:0051253 negative regulation of RNA metabolic process 1 1112 2.54e-01
GO:BP GO:0008645 hexose transmembrane transport 1 87 2.54e-01
GO:BP GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 1 102 2.54e-01
GO:BP GO:0019218 regulation of steroid metabolic process 1 68 2.54e-01
GO:BP GO:0009101 glycoprotein biosynthetic process 2 251 2.54e-01
GO:BP GO:0048675 axon extension 1 108 2.54e-01
GO:BP GO:0060425 lung morphogenesis 1 39 2.57e-01
GO:BP GO:0048468 cell development 2 1950 2.57e-01
GO:BP GO:0015749 monosaccharide transmembrane transport 1 88 2.57e-01
GO:BP GO:0008306 associative learning 1 65 2.57e-01
GO:BP GO:0071559 response to transforming growth factor beta 2 227 2.58e-01
GO:BP GO:0042310 vasoconstriction 1 51 2.58e-01
GO:BP GO:0048699 generation of neurons 1 1120 2.59e-01
GO:BP GO:1902749 regulation of cell cycle G2/M phase transition 1 105 2.61e-01
GO:BP GO:0071702 organic substance transport 7 2133 2.61e-01
GO:BP GO:0050000 chromosome localization 1 101 2.62e-01
GO:BP GO:0014706 striated muscle tissue development 2 214 2.63e-01
GO:BP GO:0030335 positive regulation of cell migration 3 408 2.63e-01
GO:BP GO:0015807 L-amino acid transport 1 62 2.63e-01
GO:BP GO:0002066 columnar/cuboidal epithelial cell development 1 39 2.65e-01
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 1 1203 2.66e-01
GO:BP GO:0051058 negative regulation of small GTPase mediated signal transduction 1 52 2.66e-01
GO:BP GO:0006094 gluconeogenesis 1 70 2.66e-01
GO:BP GO:0006112 energy reserve metabolic process 1 72 2.66e-01
GO:BP GO:0007088 regulation of mitotic nuclear division 1 99 2.66e-01
GO:BP GO:0051924 regulation of calcium ion transport 2 167 2.66e-01
GO:BP GO:0010977 negative regulation of neuron projection development 1 117 2.69e-01
GO:BP GO:0043407 negative regulation of MAP kinase activity 1 50 2.69e-01
GO:BP GO:0032330 regulation of chondrocyte differentiation 1 36 2.69e-01
GO:BP GO:0034219 carbohydrate transmembrane transport 1 95 2.69e-01
GO:BP GO:0072657 protein localization to membrane 1 530 2.69e-01
GO:BP GO:1903053 regulation of extracellular matrix organization 1 47 2.70e-01
GO:BP GO:0019319 hexose biosynthetic process 1 73 2.70e-01
GO:BP GO:0043616 keratinocyte proliferation 1 39 2.70e-01
GO:BP GO:0051240 positive regulation of multicellular organismal process 1 1103 2.72e-01
GO:BP GO:0006814 sodium ion transport 1 158 2.73e-01
GO:BP GO:0051293 establishment of spindle localization 1 49 2.73e-01
GO:BP GO:0030301 cholesterol transport 1 81 2.73e-01
GO:BP GO:0033554 cellular response to stress 7 1662 2.73e-01
GO:BP GO:0120031 plasma membrane bounded cell projection assembly 1 463 2.73e-01
GO:BP GO:0032412 regulation of monoatomic ion transmembrane transporter activity 2 189 2.73e-01
GO:BP GO:0006835 dicarboxylic acid transport 1 61 2.73e-01
GO:BP GO:0050768 negative regulation of neurogenesis 1 113 2.73e-01
GO:BP GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 2 113 2.74e-01
GO:BP GO:0007129 homologous chromosome pairing at meiosis 1 24 2.74e-01
GO:BP GO:0045893 positive regulation of DNA-templated transcription 1 1298 2.76e-01
GO:BP GO:0022008 neurogenesis 1 1297 2.76e-01
GO:BP GO:0051983 regulation of chromosome segregation 1 121 2.76e-01
GO:BP GO:0007416 synapse assembly 1 153 2.76e-01
GO:BP GO:0030031 cell projection assembly 1 473 2.76e-01
GO:BP GO:0051588 regulation of neurotransmitter transport 1 71 2.76e-01
GO:BP GO:1900024 regulation of substrate adhesion-dependent cell spreading 1 54 2.76e-01
GO:BP GO:2000147 positive regulation of cell motility 3 421 2.76e-01
GO:BP GO:0035924 cellular response to vascular endothelial growth factor stimulus 1 54 2.76e-01
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 1 1305 2.76e-01
GO:BP GO:0051952 regulation of amine transport 1 56 2.77e-01
GO:BP GO:0051961 negative regulation of nervous system development 1 119 2.78e-01
GO:BP GO:0048285 organelle fission 3 387 2.78e-01
GO:BP GO:0005975 carbohydrate metabolic process 3 439 2.80e-01
GO:BP GO:0051668 localization within membrane 1 611 2.80e-01
GO:BP GO:0051653 spindle localization 1 53 2.80e-01
GO:BP GO:0050770 regulation of axonogenesis 1 139 2.80e-01
GO:BP GO:0046364 monosaccharide biosynthetic process 1 82 2.80e-01
GO:BP GO:0022898 regulation of transmembrane transporter activity 2 200 2.80e-01
GO:BP GO:0007062 sister chromatid cohesion 1 52 2.80e-01
GO:BP GO:0007631 feeding behavior 1 51 2.80e-01
GO:BP GO:0040017 positive regulation of locomotion 3 429 2.82e-01
GO:BP GO:0070372 regulation of ERK1 and ERK2 cascade 2 192 2.82e-01
GO:BP GO:0051056 regulation of small GTPase mediated signal transduction 2 249 2.83e-01
GO:BP GO:0000086 G2/M transition of mitotic cell cycle 1 130 2.83e-01
GO:BP GO:0060350 endochondral bone morphogenesis 1 47 2.84e-01
GO:BP GO:0051254 positive regulation of RNA metabolic process 1 1425 2.86e-01
GO:BP GO:0007218 neuropeptide signaling pathway 1 36 2.86e-01
GO:BP GO:0015918 sterol transport 1 93 2.86e-01
GO:BP GO:0014910 regulation of smooth muscle cell migration 1 57 2.86e-01
GO:BP GO:1902531 regulation of intracellular signal transduction 7 1318 2.87e-01
GO:BP GO:0007093 mitotic cell cycle checkpoint signaling 1 137 2.87e-01
GO:BP GO:0008643 carbohydrate transport 1 114 2.88e-01
GO:BP GO:0098657 import into cell 3 664 2.92e-01
GO:BP GO:0015837 amine transport 1 59 2.92e-01
GO:BP GO:0032355 response to estradiol 1 79 2.92e-01
GO:BP GO:0080135 regulation of cellular response to stress 3 585 2.92e-01
GO:BP GO:0008283 cell population proliferation 2 2340 2.94e-01
GO:BP GO:0009895 negative regulation of catabolic process 1 287 2.94e-01
GO:BP GO:0090287 regulation of cellular response to growth factor stimulus 2 261 2.94e-01
GO:BP GO:0008285 negative regulation of cell population proliferation 4 643 2.97e-01
GO:BP GO:0030330 DNA damage response, signal transduction by p53 class mediator 1 70 2.97e-01
GO:BP GO:0032409 regulation of transporter activity 2 212 2.97e-01
GO:BP GO:0030334 regulation of cell migration 4 707 2.98e-01
GO:BP GO:0006024 glycosaminoglycan biosynthetic process 1 59 2.98e-01
GO:BP GO:0090596 sensory organ morphogenesis 2 179 2.98e-01
GO:BP GO:0051480 regulation of cytosolic calcium ion concentration 1 39 2.98e-01
GO:BP GO:0032368 regulation of lipid transport 1 91 2.98e-01
GO:BP GO:0045143 homologous chromosome segregation 1 32 2.98e-01
GO:BP GO:0044839 cell cycle G2/M phase transition 1 145 2.99e-01
GO:BP GO:0008203 cholesterol metabolic process 1 99 2.99e-01
GO:BP GO:0070192 chromosome organization involved in meiotic cell cycle 1 35 3.00e-01
GO:BP GO:0061061 muscle structure development 2 552 3.00e-01
GO:BP GO:0006023 aminoglycan biosynthetic process 1 61 3.00e-01
GO:BP GO:0070371 ERK1 and ERK2 cascade 2 211 3.00e-01
GO:BP GO:1990138 neuron projection extension 1 149 3.00e-01
GO:BP GO:0014909 smooth muscle cell migration 1 64 3.00e-01
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 1 1589 3.00e-01
GO:BP GO:0042176 regulation of protein catabolic process 1 328 3.00e-01
GO:BP GO:0034762 regulation of transmembrane transport 3 392 3.00e-01
GO:BP GO:0009100 glycoprotein metabolic process 2 315 3.01e-01
GO:BP GO:0140962 multicellular organismal-level chemical homeostasis 1 48 3.01e-01
GO:BP GO:0051445 regulation of meiotic cell cycle 1 45 3.02e-01
GO:BP GO:0018193 peptidyl-amino acid modification 1 866 3.02e-01
GO:BP GO:1901873 regulation of post-translational protein modification 2 302 3.04e-01
GO:BP GO:0006476 protein deacetylation 1 81 3.04e-01
GO:BP GO:0048562 embryonic organ morphogenesis 2 186 3.04e-01
GO:BP GO:0006886 intracellular protein transport 1 803 3.04e-01
GO:BP GO:0048871 multicellular organismal-level homeostasis 4 570 3.04e-01
GO:BP GO:1902652 secondary alcohol metabolic process 1 106 3.04e-01
GO:BP GO:0030308 negative regulation of cell growth 1 161 3.04e-01
GO:BP GO:0008361 regulation of cell size 1 160 3.04e-01
GO:BP GO:0008543 fibroblast growth factor receptor signaling pathway 1 59 3.04e-01
GO:BP GO:0051101 regulation of DNA binding 1 102 3.04e-01
GO:BP GO:0061035 regulation of cartilage development 1 53 3.04e-01
GO:BP GO:0045913 positive regulation of carbohydrate metabolic process 1 61 3.04e-01
GO:BP GO:0007015 actin filament organization 1 372 3.04e-01
GO:BP GO:0008015 blood circulation 2 372 3.04e-01
GO:BP GO:0090066 regulation of anatomical structure size 2 395 3.04e-01
GO:BP GO:0090090 negative regulation of canonical Wnt signaling pathway 1 114 3.04e-01
GO:BP GO:0042127 regulation of cell population proliferation 1 1568 3.09e-01
GO:BP GO:0002067 glandular epithelial cell differentiation 1 49 3.09e-01
GO:BP GO:0051321 meiotic cell cycle 2 183 3.11e-01
GO:BP GO:0048870 cell motility 2 1169 3.12e-01
GO:BP GO:0016125 sterol metabolic process 1 108 3.12e-01
GO:BP GO:0051129 negative regulation of cellular component organization 2 592 3.13e-01
GO:BP GO:0008277 regulation of G protein-coupled receptor signaling pathway 1 93 3.14e-01
GO:BP GO:0001570 vasculogenesis 1 67 3.22e-01
GO:BP GO:0007423 sensory organ development 3 395 3.22e-01
GO:BP GO:1901991 negative regulation of mitotic cell cycle phase transition 1 165 3.22e-01
GO:BP GO:0019932 second-messenger-mediated signaling 2 182 3.23e-01
GO:BP GO:2000145 regulation of cell motility 4 741 3.23e-01
GO:BP GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 1 165 3.23e-01
GO:BP GO:0055085 transmembrane transport 4 1014 3.23e-01
GO:BP GO:0043010 camera-type eye development 2 237 3.23e-01
GO:BP GO:0055088 lipid homeostasis 1 116 3.25e-01
GO:BP GO:1905952 regulation of lipid localization 1 110 3.25e-01
GO:BP GO:0014812 muscle cell migration 1 75 3.25e-01
GO:BP GO:0098813 nuclear chromosome segregation 2 264 3.28e-01
GO:BP GO:0035601 protein deacylation 1 91 3.28e-01
GO:BP GO:0000070 mitotic sister chromatid segregation 1 178 3.28e-01
GO:BP GO:1904062 regulation of monoatomic cation transmembrane transport 2 232 3.28e-01
GO:BP GO:0007049 cell cycle 7 1515 3.29e-01
GO:BP GO:0006357 regulation of transcription by RNA polymerase II 1 1764 3.29e-01
GO:BP GO:0098732 macromolecule deacylation 1 92 3.29e-01
GO:BP GO:1901137 carbohydrate derivative biosynthetic process 3 544 3.29e-01
GO:BP GO:0043087 regulation of GTPase activity 2 288 3.31e-01
GO:BP GO:0097746 blood vessel diameter maintenance 1 98 3.33e-01
GO:BP GO:0035296 regulation of tube diameter 1 98 3.33e-01
GO:BP GO:0050920 regulation of chemotaxis 1 143 3.33e-01
GO:BP GO:0000075 cell cycle checkpoint signaling 1 184 3.33e-01
GO:BP GO:0035150 regulation of tube size 1 98 3.34e-01
GO:BP GO:0006366 transcription by RNA polymerase II 1 1852 3.36e-01
GO:BP GO:1901615 organic hydroxy compound metabolic process 2 375 3.36e-01
GO:BP GO:0071897 DNA biosynthetic process 1 174 3.36e-01
GO:BP GO:1901566 organonitrogen compound biosynthetic process 2 1496 3.36e-01
GO:BP GO:0048869 cellular developmental process 13 2943 3.36e-01
GO:BP GO:0007399 nervous system development 1 1886 3.36e-01
GO:BP GO:0030154 cell differentiation 13 2942 3.36e-01
GO:BP GO:0007612 learning 1 114 3.36e-01
GO:BP GO:0048588 developmental cell growth 1 194 3.37e-01
GO:BP GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 2 298 3.38e-01
GO:BP GO:0071363 cellular response to growth factor stimulus 3 549 3.38e-01
GO:BP GO:0072091 regulation of stem cell proliferation 1 58 3.38e-01
GO:BP GO:0040012 regulation of locomotion 4 762 3.39e-01
GO:BP GO:0007411 axon guidance 1 177 3.43e-01
GO:BP GO:0010557 positive regulation of macromolecule biosynthetic process 1 1896 3.43e-01
GO:BP GO:0097485 neuron projection guidance 1 177 3.43e-01
GO:BP GO:1903510 mucopolysaccharide metabolic process 1 75 3.43e-01
GO:BP GO:0030178 negative regulation of Wnt signaling pathway 1 140 3.43e-01
GO:BP GO:0050878 regulation of body fluid levels 2 237 3.43e-01
GO:BP GO:0045132 meiotic chromosome segregation 1 51 3.43e-01
GO:BP GO:1903829 positive regulation of protein localization 1 392 3.44e-01
GO:BP GO:0016525 negative regulation of angiogenesis 1 71 3.44e-01
GO:BP GO:0070588 calcium ion transmembrane transport 2 221 3.44e-01
GO:BP GO:1901796 regulation of signal transduction by p53 class mediator 1 102 3.45e-01
GO:BP GO:0048589 developmental growth 3 522 3.46e-01
GO:BP GO:0009891 positive regulation of biosynthetic process 1 1972 3.46e-01
GO:BP GO:0048863 stem cell differentiation 1 196 3.46e-01
GO:BP GO:0090288 negative regulation of cellular response to growth factor stimulus 1 80 3.46e-01
GO:BP GO:0043255 regulation of carbohydrate biosynthetic process 1 79 3.46e-01
GO:BP GO:0070887 cellular response to chemical stimulus 1 1857 3.46e-01
GO:BP GO:0045926 negative regulation of growth 1 204 3.46e-01
GO:BP GO:2000181 negative regulation of blood vessel morphogenesis 1 72 3.46e-01
GO:BP GO:1901343 negative regulation of vasculature development 1 72 3.46e-01
GO:BP GO:0031328 positive regulation of cellular biosynthetic process 1 1958 3.46e-01
GO:BP GO:0034446 substrate adhesion-dependent cell spreading 1 90 3.46e-01
GO:BP GO:0070925 organelle assembly 1 828 3.46e-01
GO:BP GO:1990830 cellular response to leukemia inhibitory factor 1 86 3.46e-01
GO:BP GO:0051100 negative regulation of binding 1 133 3.46e-01
GO:BP GO:1990823 response to leukemia inhibitory factor 1 87 3.48e-01
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 1 1669 3.48e-01
GO:BP GO:0033138 positive regulation of peptidyl-serine phosphorylation 1 68 3.52e-01
GO:BP GO:0070848 response to growth factor 3 571 3.52e-01
GO:BP GO:0044344 cellular response to fibroblast growth factor stimulus 1 81 3.52e-01
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 1 1708 3.52e-01
GO:BP GO:0042472 inner ear morphogenesis 1 59 3.53e-01
GO:BP GO:0071901 negative regulation of protein serine/threonine kinase activity 1 96 3.53e-01
GO:BP GO:0009890 negative regulation of biosynthetic process 1 1721 3.53e-01
GO:BP GO:0071347 cellular response to interleukin-1 1 64 3.57e-01
GO:BP GO:0001657 ureteric bud development 1 75 3.58e-01
GO:BP GO:0045930 negative regulation of mitotic cell cycle 1 209 3.58e-01
GO:BP GO:0000819 sister chromatid segregation 1 217 3.59e-01
GO:BP GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 1 78 3.59e-01
GO:BP GO:0072163 mesonephric epithelium development 1 76 3.59e-01
GO:BP GO:0072164 mesonephric tubule development 1 76 3.59e-01
GO:BP GO:0050796 regulation of insulin secretion 1 119 3.61e-01
GO:BP GO:0035556 intracellular signal transduction 9 2036 3.65e-01
GO:BP GO:0010721 negative regulation of cell development 1 190 3.66e-01
GO:BP GO:0008217 regulation of blood pressure 1 114 3.66e-01
GO:BP GO:0051239 regulation of multicellular organismal process 1 2052 3.66e-01
GO:BP GO:0071774 response to fibroblast growth factor 1 85 3.66e-01
GO:BP GO:0065004 protein-DNA complex assembly 1 171 3.67e-01
GO:BP GO:0001823 mesonephros development 1 77 3.67e-01
GO:BP GO:0030036 actin cytoskeleton organization 1 566 3.76e-01
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 1 2367 3.76e-01
GO:BP GO:0030203 glycosaminoglycan metabolic process 1 87 3.77e-01
GO:BP GO:0050804 modulation of chemical synaptic transmission 1 343 3.79e-01
GO:BP GO:0099177 regulation of trans-synaptic signaling 1 344 3.79e-01
GO:BP GO:0001505 regulation of neurotransmitter levels 1 132 3.80e-01
GO:BP GO:0033044 regulation of chromosome organization 1 235 3.80e-01
GO:BP GO:0010959 regulation of metal ion transport 2 271 3.82e-01
GO:BP GO:0006006 glucose metabolic process 1 153 3.84e-01
GO:BP GO:1901988 negative regulation of cell cycle phase transition 1 234 3.86e-01
GO:BP GO:0016567 protein ubiquitination 3 684 3.90e-01
GO:BP GO:0031324 negative regulation of cellular metabolic process 1 2069 3.91e-01
GO:BP GO:0055007 cardiac muscle cell differentiation 1 108 3.91e-01
GO:BP GO:0010811 positive regulation of cell-substrate adhesion 1 99 3.94e-01
GO:BP GO:0002062 chondrocyte differentiation 1 89 3.94e-01
GO:BP GO:0030855 epithelial cell differentiation 3 439 3.94e-01
GO:BP GO:0042471 ear morphogenesis 1 73 3.94e-01
GO:BP GO:0006022 aminoglycan metabolic process 1 92 3.95e-01
GO:BP GO:0006936 muscle contraction 1 266 3.95e-01
GO:BP GO:0001667 ameboidal-type cell migration 2 358 3.97e-01
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 1 2131 3.97e-01
GO:BP GO:0007626 locomotory behavior 1 139 3.97e-01
GO:BP GO:0072089 stem cell proliferation 1 84 3.97e-01
GO:BP GO:0048638 regulation of developmental growth 1 254 3.99e-01
GO:BP GO:0002065 columnar/cuboidal epithelial cell differentiation 1 80 3.99e-01
GO:BP GO:0090276 regulation of peptide hormone secretion 1 135 3.99e-01
GO:BP GO:0015031 protein transport 1 1366 4.00e-01
GO:BP GO:0046907 intracellular transport 1 1440 4.00e-01
GO:BP GO:0030073 insulin secretion 1 144 4.01e-01
GO:BP GO:0030029 actin filament-based process 1 643 4.01e-01
GO:BP GO:0002791 regulation of peptide secretion 1 137 4.01e-01
GO:BP GO:0031325 positive regulation of cellular metabolic process 1 2518 4.01e-01
GO:BP GO:0140014 mitotic nuclear division 1 251 4.01e-01
GO:BP GO:0030326 embryonic limb morphogenesis 1 89 4.01e-01
GO:BP GO:0035113 embryonic appendage morphogenesis 1 89 4.01e-01
GO:BP GO:0090087 regulation of peptide transport 1 139 4.01e-01
GO:BP GO:0006355 regulation of DNA-templated transcription 1 2560 4.01e-01
GO:BP GO:0034502 protein localization to chromosome 1 101 4.02e-01
GO:BP GO:0070555 response to interleukin-1 1 82 4.02e-01
GO:BP GO:0060537 muscle tissue development 2 347 4.02e-01
GO:BP GO:2001141 regulation of RNA biosynthetic process 1 2577 4.02e-01
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 1 2607 4.04e-01
GO:BP GO:0051051 negative regulation of transport 2 317 4.05e-01
GO:BP GO:0051241 negative regulation of multicellular organismal process 4 744 4.05e-01
GO:BP GO:0033135 regulation of peptidyl-serine phosphorylation 1 97 4.05e-01
GO:BP GO:0042981 regulation of apoptotic process 5 1092 4.05e-01
GO:BP GO:0040013 negative regulation of locomotion 1 262 4.05e-01
GO:BP GO:0034329 cell junction assembly 1 347 4.06e-01
GO:BP GO:0072330 monocarboxylic acid biosynthetic process 1 146 4.07e-01
GO:BP GO:0043547 positive regulation of GTPase activity 1 211 4.07e-01
GO:BP GO:0097435 supramolecular fiber organization 1 666 4.07e-01
GO:BP GO:0009892 negative regulation of metabolic process 1 2297 4.07e-01
GO:BP GO:0006351 DNA-templated transcription 1 2669 4.07e-01
GO:BP GO:0045184 establishment of protein localization 1 1468 4.08e-01
GO:BP GO:0051656 establishment of organelle localization 2 397 4.08e-01
GO:BP GO:0032774 RNA biosynthetic process 1 2699 4.10e-01
GO:BP GO:0007059 chromosome segregation 2 360 4.10e-01
GO:BP GO:0048585 negative regulation of response to stimulus 5 1267 4.12e-01
GO:BP GO:0010948 negative regulation of cell cycle process 1 271 4.12e-01
GO:BP GO:0060828 regulation of canonical Wnt signaling pathway 1 214 4.15e-01
GO:BP GO:0007127 meiosis I 1 73 4.15e-01
GO:BP GO:0006816 calcium ion transport 2 275 4.18e-01
GO:BP GO:0048565 digestive tract development 1 92 4.19e-01
GO:BP GO:0051252 regulation of RNA metabolic process 1 2824 4.22e-01
GO:BP GO:0006810 transport 2 3294 4.24e-01
GO:BP GO:0019318 hexose metabolic process 1 187 4.24e-01
GO:BP GO:0050808 synapse organization 1 373 4.24e-01
GO:BP GO:0043067 regulation of programmed cell death 5 1124 4.24e-01
GO:BP GO:0009893 positive regulation of metabolic process 1 2846 4.25e-01
GO:BP GO:0061982 meiosis I cell cycle process 1 77 4.26e-01
GO:BP GO:0010634 positive regulation of epithelial cell migration 1 132 4.27e-01
GO:BP GO:0045444 fat cell differentiation 1 187 4.27e-01
GO:BP GO:0032535 regulation of cellular component size 1 306 4.27e-01
GO:BP GO:0009968 negative regulation of signal transduction 4 1017 4.28e-01
GO:BP GO:0040011 locomotion 4 854 4.28e-01
GO:BP GO:0032446 protein modification by small protein conjugation 3 759 4.28e-01
GO:BP GO:0048754 branching morphogenesis of an epithelial tube 1 121 4.28e-01
GO:BP GO:0023051 regulation of signaling 9 2560 4.30e-01
GO:BP GO:0015850 organic hydroxy compound transport 1 181 4.30e-01
GO:BP GO:1901617 organic hydroxy compound biosynthetic process 1 174 4.30e-01
GO:BP GO:0006950 response to stress 1 2763 4.30e-01
GO:BP GO:0034765 regulation of monoatomic ion transmembrane transport 2 296 4.31e-01
GO:BP GO:0010646 regulation of cell communication 9 2567 4.33e-01
GO:BP GO:0055123 digestive system development 1 100 4.33e-01
GO:BP GO:0048731 system development 1 2886 4.33e-01
GO:BP GO:0048568 embryonic organ development 2 314 4.33e-01
GO:BP GO:0008366 axon ensheathment 1 116 4.33e-01
GO:BP GO:1901990 regulation of mitotic cell cycle phase transition 1 305 4.33e-01
GO:BP GO:0007272 ensheathment of neurons 1 116 4.33e-01
GO:BP GO:0030072 peptide hormone secretion 1 169 4.33e-01
GO:BP GO:0008033 tRNA processing 1 131 4.33e-01
GO:BP GO:0042552 myelination 1 114 4.33e-01
GO:BP GO:0042221 response to chemical 1 2456 4.33e-01
GO:BP GO:0003012 muscle system process 1 334 4.33e-01
GO:BP GO:0007605 sensory perception of sound 1 97 4.33e-01
GO:BP GO:0035051 cardiocyte differentiation 1 134 4.34e-01
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 1 3054 4.34e-01
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 1 3059 4.35e-01
GO:BP GO:0051234 establishment of localization 2 3453 4.35e-01
GO:BP GO:1903522 regulation of blood circulation 1 197 4.35e-01
GO:BP GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 1 123 4.35e-01
GO:BP GO:0035108 limb morphogenesis 1 113 4.35e-01
GO:BP GO:0035107 appendage morphogenesis 1 113 4.35e-01
GO:BP GO:0002790 peptide secretion 1 173 4.35e-01
GO:BP GO:0018130 heterocycle biosynthetic process 1 3115 4.38e-01
GO:BP GO:0072331 signal transduction by p53 class mediator 1 163 4.38e-01
GO:BP GO:0019438 aromatic compound biosynthetic process 1 3116 4.38e-01
GO:BP GO:0072073 kidney epithelium development 1 113 4.38e-01
GO:BP GO:0120036 plasma membrane bounded cell projection organization 1 1203 4.38e-01
GO:BP GO:1902850 microtubule cytoskeleton organization involved in mitosis 1 157 4.39e-01
GO:BP GO:0046883 regulation of hormone secretion 1 171 4.40e-01
GO:BP GO:0051179 localization 4 3983 4.40e-01
GO:BP GO:0035264 multicellular organism growth 1 124 4.42e-01
GO:BP GO:0007611 learning or memory 1 201 4.42e-01
GO:BP GO:0071705 nitrogen compound transport 1 1689 4.43e-01
GO:BP GO:0098662 inorganic cation transmembrane transport 3 537 4.44e-01
GO:BP GO:0030030 cell projection organization 1 1236 4.44e-01
GO:BP GO:0010639 negative regulation of organelle organization 1 310 4.44e-01
GO:BP GO:0050708 regulation of protein secretion 1 186 4.46e-01
GO:BP GO:1901362 organic cyclic compound biosynthetic process 1 3221 4.46e-01
GO:BP GO:0008202 steroid metabolic process 1 203 4.49e-01
GO:BP GO:0015833 peptide transport 1 182 4.50e-01
GO:BP GO:0001558 regulation of cell growth 1 352 4.50e-01
GO:BP GO:0060070 canonical Wnt signaling pathway 1 254 4.53e-01
GO:BP GO:0032102 negative regulation of response to external stimulus 1 291 4.53e-01
GO:BP GO:0062012 regulation of small molecule metabolic process 1 248 4.53e-01
GO:BP GO:0051649 establishment of localization in cell 1 1842 4.53e-01
GO:BP GO:0042770 signal transduction in response to DNA damage 1 180 4.54e-01
GO:BP GO:0043405 regulation of MAP kinase activity 1 141 4.57e-01
GO:BP GO:0098655 monoatomic cation transmembrane transport 3 554 4.59e-01
GO:BP GO:0050954 sensory perception of mechanical stimulus 1 111 4.61e-01
GO:BP GO:0046578 regulation of Ras protein signal transduction 1 156 4.61e-01
GO:BP GO:0010975 regulation of neuron projection development 1 374 4.61e-01
GO:BP GO:0009888 tissue development 6 1425 4.61e-01
GO:BP GO:0061351 neural precursor cell proliferation 1 122 4.61e-01
GO:BP GO:0007409 axonogenesis 1 350 4.61e-01
GO:BP GO:0048592 eye morphogenesis 1 114 4.61e-01
GO:BP GO:0045786 negative regulation of cell cycle 1 337 4.61e-01
GO:BP GO:0032880 regulation of protein localization 1 719 4.61e-01
GO:BP GO:0030324 lung development 1 144 4.61e-01
GO:BP GO:0061138 morphogenesis of a branching epithelium 1 143 4.61e-01
GO:BP GO:0030323 respiratory tube development 1 148 4.66e-01
GO:BP GO:0006109 regulation of carbohydrate metabolic process 1 147 4.66e-01
GO:BP GO:0030001 metal ion transport 2 568 4.66e-01
GO:BP GO:0007275 multicellular organism development 1 3355 4.66e-01
GO:BP GO:0019216 regulation of lipid metabolic process 1 251 4.66e-01
GO:BP GO:0010648 negative regulation of cell communication 4 1088 4.66e-01
GO:BP GO:0051235 maintenance of location 1 263 4.66e-01
GO:BP GO:0030111 regulation of Wnt signaling pathway 1 274 4.66e-01
GO:BP GO:0023057 negative regulation of signaling 4 1090 4.66e-01
GO:BP GO:0006935 chemotaxis 1 264 4.66e-01
GO:BP GO:0140694 non-membrane-bounded organelle assembly 1 364 4.66e-01
GO:BP GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction 1 144 4.66e-01
GO:BP GO:0042330 taxis 1 264 4.66e-01
GO:BP GO:0006518 peptide metabolic process 1 781 4.66e-01
GO:BP GO:0031399 regulation of protein modification process 4 1096 4.67e-01
GO:BP GO:0032879 regulation of localization 4 1570 4.70e-01
GO:BP GO:0008104 protein localization 2 2128 4.72e-01
GO:BP GO:0070727 cellular macromolecule localization 2 2137 4.73e-01
GO:BP GO:0009967 positive regulation of signal transduction 5 1116 4.73e-01
GO:BP GO:0001501 skeletal system development 2 361 4.76e-01
GO:BP GO:0048839 inner ear development 1 129 4.76e-01
GO:BP GO:0001763 morphogenesis of a branching structure 1 155 4.79e-01
GO:BP GO:0071824 protein-DNA complex organization 2 711 4.79e-01
GO:BP GO:0048736 appendage development 1 141 4.83e-01
GO:BP GO:0060173 limb development 1 141 4.83e-01
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 1 3743 4.83e-01
GO:BP GO:0006066 alcohol metabolic process 1 263 4.83e-01
GO:BP GO:0046879 hormone secretion 1 212 4.83e-01
GO:BP GO:0009416 response to light stimulus 1 241 4.84e-01
GO:BP GO:0009410 response to xenobiotic stimulus 1 275 4.84e-01
GO:BP GO:0098660 inorganic ion transmembrane transport 2 582 4.84e-01
GO:BP GO:1901987 regulation of cell cycle phase transition 1 387 4.85e-01
GO:BP GO:0016049 cell growth 1 416 4.85e-01
GO:BP GO:0060341 regulation of cellular localization 1 805 4.85e-01
GO:BP GO:0070374 positive regulation of ERK1 and ERK2 cascade 1 120 4.85e-01
GO:BP GO:0060541 respiratory system development 1 161 4.86e-01
GO:BP GO:0046394 carboxylic acid biosynthetic process 1 223 4.87e-01
GO:BP GO:0061564 axon development 1 388 4.89e-01
GO:BP GO:0050679 positive regulation of epithelial cell proliferation 1 152 4.89e-01
GO:BP GO:0016053 organic acid biosynthetic process 1 224 4.89e-01
GO:BP GO:0009914 hormone transport 1 217 4.89e-01
GO:BP GO:0001932 regulation of protein phosphorylation 3 758 4.89e-01
GO:BP GO:0051640 organelle localization 2 521 4.90e-01
GO:BP GO:0009755 hormone-mediated signaling pathway 1 142 4.90e-01
GO:BP GO:0009894 regulation of catabolic process 1 883 4.90e-01
GO:BP GO:0070647 protein modification by small protein conjugation or removal 3 870 4.90e-01
GO:BP GO:0044772 mitotic cell cycle phase transition 1 411 4.91e-01
GO:BP GO:0045859 regulation of protein kinase activity 2 473 4.91e-01
GO:BP GO:0032501 multicellular organismal process 9 4807 4.91e-01
GO:BP GO:0040007 growth 3 737 4.94e-01
GO:BP GO:0043086 negative regulation of catalytic activity 2 456 4.95e-01
GO:BP GO:0015980 energy derivation by oxidation of organic compounds 1 288 4.96e-01
GO:BP GO:0010810 regulation of cell-substrate adhesion 1 171 4.96e-01
GO:BP GO:0016477 cell migration 2 1065 4.96e-01
GO:BP GO:0030163 protein catabolic process 1 906 4.97e-01
GO:BP GO:1901135 carbohydrate derivative metabolic process 1 841 5.00e-01
GO:BP GO:0019752 carboxylic acid metabolic process 2 684 5.02e-01
GO:BP GO:0043269 regulation of monoatomic ion transport 2 369 5.02e-01
GO:BP GO:0043583 ear development 1 150 5.06e-01
GO:BP GO:0051216 cartilage development 1 149 5.06e-01
GO:BP GO:0006996 organelle organization 2 2974 5.09e-01
GO:BP GO:0042886 amide transport 1 237 5.12e-01
GO:BP GO:0006399 tRNA metabolic process 1 189 5.12e-01
GO:BP GO:0048856 anatomical structure development 2 4100 5.12e-01
GO:BP GO:0010632 regulation of epithelial cell migration 1 195 5.12e-01
GO:BP GO:0043436 oxoacid metabolic process 2 699 5.12e-01
GO:BP GO:0002064 epithelial cell development 1 156 5.12e-01
GO:BP GO:0071356 cellular response to tumor necrosis factor 1 159 5.13e-01
GO:BP GO:0048514 blood vessel morphogenesis 2 461 5.13e-01
GO:BP GO:0006082 organic acid metabolic process 2 703 5.14e-01
GO:BP GO:0010468 regulation of gene expression 1 3587 5.15e-01
GO:BP GO:0048667 cell morphogenesis involved in neuron differentiation 1 451 5.15e-01
GO:BP GO:0034330 cell junction organization 1 586 5.15e-01
GO:BP GO:0009306 protein secretion 1 262 5.15e-01
GO:BP GO:0051098 regulation of binding 1 314 5.15e-01
GO:BP GO:0006869 lipid transport 1 271 5.15e-01
GO:BP GO:0007346 regulation of mitotic cell cycle 1 438 5.15e-01
GO:BP GO:0035592 establishment of protein localization to extracellular region 1 262 5.15e-01
GO:BP GO:0048523 negative regulation of cellular process 1 3773 5.15e-01
GO:BP GO:0031344 regulation of cell projection organization 2 542 5.20e-01
GO:BP GO:0007507 heart development 2 512 5.20e-01
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 1 4243 5.20e-01
GO:BP GO:0071692 protein localization to extracellular region 1 266 5.20e-01
GO:BP GO:0034220 monoatomic ion transmembrane transport 2 650 5.21e-01
GO:BP GO:2000241 regulation of reproductive process 1 126 5.21e-01
GO:BP GO:0010556 regulation of macromolecule biosynthetic process 1 3702 5.22e-01
GO:BP GO:0033036 macromolecule localization 1 2448 5.24e-01
GO:BP GO:0048738 cardiac muscle tissue development 1 202 5.25e-01
GO:BP GO:0022402 cell cycle process 4 1078 5.25e-01
GO:BP GO:0048522 positive regulation of cellular process 1 4197 5.27e-01
GO:BP GO:0033365 protein localization to organelle 1 860 5.27e-01
GO:BP GO:0006812 monoatomic cation transport 2 677 5.27e-01
GO:BP GO:0031326 regulation of cellular biosynthetic process 1 3794 5.30e-01
GO:BP GO:0080090 regulation of primary metabolic process 1 4371 5.30e-01
GO:BP GO:0009889 regulation of biosynthetic process 1 3820 5.32e-01
GO:BP GO:0043603 amide metabolic process 1 1003 5.33e-01
GO:BP GO:0034612 response to tumor necrosis factor 1 176 5.33e-01
GO:BP GO:0040008 regulation of growth 1 493 5.33e-01
GO:BP GO:0048598 embryonic morphogenesis 2 438 5.33e-01
GO:BP GO:0006631 fatty acid metabolic process 1 276 5.34e-01
GO:BP GO:0042325 regulation of phosphorylation 3 841 5.34e-01
GO:BP GO:0048519 negative regulation of biological process 1 4026 5.39e-01
GO:BP GO:0016055 Wnt signaling pathway 1 379 5.42e-01
GO:BP GO:0036211 protein modification process 1 2751 5.42e-01
GO:BP GO:0010876 lipid localization 1 309 5.42e-01
GO:BP GO:0048812 neuron projection morphogenesis 1 500 5.42e-01
GO:BP GO:0044770 cell cycle phase transition 1 496 5.42e-01
GO:BP GO:0198738 cell-cell signaling by wnt 1 380 5.42e-01
GO:BP GO:0120035 regulation of plasma membrane bounded cell projection organization 1 529 5.42e-01
GO:BP GO:0003007 heart morphogenesis 1 217 5.42e-01
GO:BP GO:0043549 regulation of kinase activity 2 548 5.47e-01
GO:BP GO:0120039 plasma membrane bounded cell projection morphogenesis 1 515 5.47e-01
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 1 157 5.49e-01
GO:BP GO:0006417 regulation of translation 1 373 5.49e-01
GO:BP GO:0048858 cell projection morphogenesis 1 519 5.49e-01
GO:BP GO:0042592 homeostatic process 5 1189 5.51e-01
GO:BP GO:0071495 cellular response to endogenous stimulus 4 1097 5.53e-01
GO:BP GO:0009887 animal organ morphogenesis 3 725 5.53e-01
GO:BP GO:0009314 response to radiation 1 339 5.53e-01
GO:BP GO:0051049 regulation of transport 3 1268 5.53e-01
GO:BP GO:0009966 regulation of signal transduction 7 2271 5.53e-01
GO:BP GO:0045765 regulation of angiogenesis 1 200 5.53e-01
GO:BP GO:0032502 developmental process 2 4445 5.55e-01
GO:BP GO:0051276 chromosome organization 2 533 5.55e-01
GO:BP GO:0032990 cell part morphogenesis 1 539 5.55e-01
GO:BP GO:1901342 regulation of vasculature development 1 202 5.55e-01
GO:BP GO:0048518 positive regulation of biological process 1 4566 5.55e-01
GO:BP GO:0010647 positive regulation of cell communication 5 1249 5.57e-01
GO:BP GO:0023056 positive regulation of signaling 5 1252 5.57e-01
GO:BP GO:0043412 macromolecule modification 1 2948 5.57e-01
GO:BP GO:0045165 cell fate commitment 1 157 5.57e-01
GO:BP GO:0051641 cellular localization 1 2822 5.59e-01
GO:BP GO:0051345 positive regulation of hydrolase activity 1 412 5.60e-01
GO:BP GO:0001568 blood vessel development 2 537 5.60e-01
GO:BP GO:0006915 apoptotic process 5 1452 5.68e-01
GO:BP GO:0098609 cell-cell adhesion 1 599 5.68e-01
GO:BP GO:0035295 tube development 3 822 5.68e-01
GO:BP GO:1901565 organonitrogen compound catabolic process 1 1151 5.68e-01
GO:BP GO:0009057 macromolecule catabolic process 1 1215 5.75e-01
GO:BP GO:0018105 peptidyl-serine phosphorylation 1 242 5.78e-01
GO:BP GO:0021537 telencephalon development 1 208 5.78e-01
GO:BP GO:0048878 chemical homeostasis 3 689 5.78e-01
GO:BP GO:1903047 mitotic cell cycle process 2 689 5.78e-01
GO:BP GO:0044281 small molecule metabolic process 3 1386 5.78e-01
GO:BP GO:0001944 vasculature development 2 562 5.79e-01
GO:BP GO:0051346 negative regulation of hydrolase activity 1 206 5.79e-01
GO:BP GO:0061448 connective tissue development 1 212 5.83e-01
GO:BP GO:0010631 epithelial cell migration 1 253 5.83e-01
GO:BP GO:0034248 regulation of amide metabolic process 1 426 5.83e-01
GO:BP GO:0051146 striated muscle cell differentiation 1 239 5.83e-01
GO:BP GO:0031323 regulation of cellular metabolic process 1 4563 5.83e-01
GO:BP GO:0090132 epithelium migration 1 253 5.84e-01
GO:BP GO:0072359 circulatory system development 3 888 5.85e-01
GO:BP GO:0060255 regulation of macromolecule metabolic process 1 4593 5.85e-01
GO:BP GO:0023061 signal release 1 329 5.85e-01
GO:BP GO:0006811 monoatomic ion transport 1 788 5.88e-01
GO:BP GO:0090130 tissue migration 1 257 5.89e-01
GO:BP GO:0050877 nervous system process 1 628 5.89e-01
GO:BP GO:0022409 positive regulation of cell-cell adhesion 1 188 5.89e-01
GO:BP GO:0018209 peptidyl-serine modification 1 254 5.90e-01
GO:BP GO:0009059 macromolecule biosynthetic process 2 5148 5.92e-01
GO:BP GO:0012501 programmed cell death 5 1498 5.93e-01
GO:BP GO:0032989 cellular component morphogenesis 1 627 5.93e-01
GO:BP GO:0016070 RNA metabolic process 1 3573 5.93e-01
GO:BP GO:0030198 extracellular matrix organization 1 233 5.94e-01
GO:BP GO:0019220 regulation of phosphate metabolic process 3 949 5.94e-01
GO:BP GO:0008219 cell death 5 1504 5.94e-01
GO:BP GO:0043062 extracellular structure organization 1 234 5.94e-01
GO:BP GO:0051174 regulation of phosphorus metabolic process 3 950 5.94e-01
GO:BP GO:0045229 external encapsulating structure organization 1 234 5.94e-01
GO:BP GO:0060562 epithelial tube morphogenesis 1 276 5.97e-01
GO:BP GO:0007265 Ras protein signal transduction 1 287 5.97e-01
GO:BP GO:0051223 regulation of protein transport 1 404 5.98e-01
GO:BP GO:0006091 generation of precursor metabolites and energy 1 423 5.98e-01
GO:BP GO:0043687 post-translational protein modification 3 1102 5.99e-01
GO:BP GO:0065009 regulation of molecular function 6 1905 6.07e-01
GO:BP GO:0007420 brain development 2 546 6.08e-01
GO:BP GO:0071900 regulation of protein serine/threonine kinase activity 1 274 6.10e-01
GO:BP GO:0010564 regulation of cell cycle process 1 622 6.12e-01
GO:BP GO:0070201 regulation of establishment of protein localization 1 428 6.13e-01
GO:BP GO:0019222 regulation of metabolic process 1 4998 6.14e-01
GO:BP GO:0051338 regulation of transferase activity 2 664 6.15e-01
GO:BP GO:0010817 regulation of hormone levels 1 337 6.17e-01
GO:BP GO:0031589 cell-substrate adhesion 1 271 6.18e-01
GO:BP GO:0044057 regulation of system process 1 398 6.20e-01
GO:BP GO:0051716 cellular response to stimulus 1 4929 6.20e-01
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 1 680 6.21e-01
GO:BP GO:0090304 nucleic acid metabolic process 1 4018 6.25e-01
GO:BP GO:0071345 cellular response to cytokine stimulus 2 544 6.25e-01
GO:BP GO:0080134 regulation of response to stress 3 1074 6.25e-01
GO:BP GO:1903530 regulation of secretion by cell 1 382 6.26e-01
GO:BP GO:0006874 intracellular calcium ion homeostasis 1 208 6.27e-01
GO:BP GO:0030522 intracellular receptor signaling pathway 1 256 6.29e-01
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 1 210 6.29e-01
GO:BP GO:0050678 regulation of epithelial cell proliferation 1 268 6.30e-01
GO:BP GO:0065003 protein-containing complex assembly 1 1320 6.32e-01
GO:BP GO:0060322 head development 2 588 6.35e-01
GO:BP GO:0060429 epithelium development 3 849 6.35e-01
GO:BP GO:0044283 small molecule biosynthetic process 1 432 6.35e-01
GO:BP GO:0035239 tube morphogenesis 2 663 6.49e-01
GO:BP GO:0009719 response to endogenous stimulus 4 1260 6.49e-01
GO:BP GO:0055074 calcium ion homeostasis 1 221 6.51e-01
GO:BP GO:0000902 cell morphogenesis 1 740 6.53e-01
GO:BP GO:0000278 mitotic cell cycle 2 815 6.55e-01
GO:BP GO:0051046 regulation of secretion 1 413 6.55e-01
GO:BP GO:0007610 behavior 1 439 6.55e-01
GO:BP GO:0006139 nucleobase-containing compound metabolic process 1 4423 6.55e-01
GO:BP GO:0032787 monocarboxylic acid metabolic process 1 434 6.59e-01
GO:BP GO:0007159 leukocyte cell-cell adhesion 1 233 6.61e-01
GO:BP GO:0051246 regulation of protein metabolic process 5 1895 6.62e-01
GO:BP GO:0031175 neuron projection development 1 774 6.63e-01
GO:BP GO:0006629 lipid metabolic process 2 989 6.65e-01
GO:BP GO:0046483 heterocycle metabolic process 1 4537 6.66e-01
GO:BP GO:0044249 cellular biosynthetic process 2 5813 6.67e-01
GO:BP GO:0006725 cellular aromatic compound metabolic process 1 4561 6.69e-01
GO:BP GO:0042692 muscle cell differentiation 1 329 6.69e-01
GO:BP GO:0048513 animal organ development 7 2156 6.70e-01
GO:BP GO:0051336 regulation of hydrolase activity 2 680 6.71e-01
GO:BP GO:0006338 chromatin remodeling 1 520 6.71e-01
GO:BP GO:0034097 response to cytokine 2 609 6.71e-01
GO:BP GO:0007600 sensory perception 2 259 6.71e-01
GO:BP GO:1901576 organic substance biosynthetic process 2 5875 6.73e-01
GO:BP GO:0007167 enzyme-linked receptor protein signaling pathway 2 741 6.78e-01
GO:BP GO:0009058 biosynthetic process 2 5912 6.78e-01
GO:BP GO:1901360 organic cyclic compound metabolic process 1 4713 6.82e-01
GO:BP GO:0032101 regulation of response to external stimulus 1 690 6.83e-01
GO:BP GO:0048583 regulation of response to stimulus 8 2877 6.84e-01
GO:BP GO:0050673 epithelial cell proliferation 1 318 6.86e-01
GO:BP GO:0030900 forebrain development 1 290 6.88e-01
GO:BP GO:0006468 protein phosphorylation 3 1130 6.89e-01
GO:BP GO:0019538 protein metabolic process 1 4202 6.91e-01
GO:BP GO:0034641 cellular nitrogen compound metabolic process 1 4913 6.91e-01
GO:BP GO:0023052 signaling 10 4134 6.97e-01
GO:BP GO:1901575 organic substance catabolic process 1 1731 7.05e-01
GO:BP GO:0043933 protein-containing complex organization 1 1964 7.07e-01
GO:BP GO:0007155 cell adhesion 1 996 7.07e-01
GO:BP GO:0048666 neuron development 1 873 7.07e-01
GO:BP GO:0022407 regulation of cell-cell adhesion 1 292 7.08e-01
GO:BP GO:0045785 positive regulation of cell adhesion 1 319 7.08e-01
GO:BP GO:0050896 response to stimulus 1 5721 7.12e-01
GO:BP GO:0006412 translation 1 657 7.18e-01
GO:BP GO:0007154 cell communication 10 4210 7.19e-01
GO:BP GO:0034470 ncRNA processing 1 397 7.21e-01
GO:BP GO:0007417 central nervous system development 1 750 7.22e-01
GO:BP GO:0006259 DNA metabolic process 1 886 7.23e-01
GO:BP GO:0010467 gene expression 1 4733 7.26e-01
GO:BP GO:0006325 chromatin organization 1 631 7.29e-01
GO:BP GO:0043043 peptide biosynthetic process 1 677 7.29e-01
GO:BP GO:0002009 morphogenesis of an epithelium 1 415 7.30e-01
GO:BP GO:0001525 angiogenesis 1 389 7.33e-01
GO:BP GO:0032940 secretion by cell 1 573 7.43e-01
GO:BP GO:0048584 positive regulation of response to stimulus 5 1557 7.43e-01
GO:BP GO:0033993 response to lipid 1 594 7.60e-01
GO:BP GO:0033043 regulation of organelle organization 1 1001 7.60e-01
GO:BP GO:0014070 response to organic cyclic compound 1 634 7.60e-01
GO:BP GO:0022607 cellular component assembly 1 2459 7.61e-01
GO:BP GO:0043085 positive regulation of catalytic activity 1 815 7.61e-01
GO:BP GO:1901564 organonitrogen compound metabolic process 1 4919 7.62e-01
GO:BP GO:0140352 export from cell 1 617 7.67e-01
GO:BP GO:0009056 catabolic process 1 2108 7.67e-01
GO:BP GO:0016310 phosphorylation 3 1338 7.79e-01
GO:BP GO:0043604 amide biosynthetic process 1 785 7.82e-01
GO:BP GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 1 470 7.82e-01
GO:BP GO:0044085 cellular component biogenesis 1 2722 7.83e-01
GO:BP GO:0051128 regulation of cellular component organization 2 1981 7.83e-01
GO:BP GO:0030003 intracellular monoatomic cation homeostasis 1 364 7.84e-01
GO:BP GO:0098771 inorganic ion homeostasis 1 355 7.88e-01
GO:BP GO:0046903 secretion 1 647 7.88e-01
GO:BP GO:0006873 intracellular monoatomic ion homeostasis 1 369 7.88e-01
GO:BP GO:0048729 tissue morphogenesis 1 501 7.88e-01
GO:BP GO:0009790 embryo development 2 859 7.91e-01
GO:BP GO:0050790 regulation of catalytic activity 3 1349 7.92e-01
GO:BP GO:0044255 cellular lipid metabolic process 1 736 8.03e-01
GO:BP GO:0032870 cellular response to hormone stimulus 1 449 8.03e-01
GO:BP GO:0001934 positive regulation of protein phosphorylation 1 465 8.03e-01
GO:BP GO:0055080 monoatomic cation homeostasis 1 410 8.26e-01
GO:BP GO:0006807 nitrogen compound metabolic process 2 7431 8.29e-01
GO:BP GO:0010608 post-transcriptional regulation of gene expression 1 475 8.29e-01
GO:BP GO:0050801 monoatomic ion homeostasis 1 416 8.29e-01
GO:BP GO:0034660 ncRNA metabolic process 1 561 8.30e-01
GO:BP GO:0042327 positive regulation of phosphorylation 1 511 8.31e-01
GO:BP GO:0009628 response to abiotic stimulus 1 848 8.33e-01
GO:BP GO:0065008 regulation of biological quality 3 2085 8.40e-01
GO:BP GO:0043170 macromolecule metabolic process 2 7084 8.54e-01
GO:BP GO:0007186 G protein-coupled receptor signaling pathway 1 386 8.54e-01
GO:BP GO:0045937 positive regulation of phosphate metabolic process 1 559 8.56e-01
GO:BP GO:0030155 regulation of cell adhesion 1 535 8.56e-01
GO:BP GO:0010562 positive regulation of phosphorus metabolic process 1 559 8.56e-01
GO:BP GO:0044093 positive regulation of molecular function 1 1132 8.56e-01
GO:BP GO:0006974 DNA damage response 1 795 8.67e-01
GO:BP GO:0055082 intracellular chemical homeostasis 1 498 8.74e-01
GO:BP GO:0043066 negative regulation of apoptotic process 1 662 8.84e-01
GO:BP GO:0031401 positive regulation of protein modification process 1 664 8.86e-01
GO:BP GO:0050794 regulation of cellular process 1 7632 8.90e-01
GO:BP GO:0043069 negative regulation of programmed cell death 1 685 8.90e-01
GO:BP GO:0044238 primary metabolic process 2 7788 8.93e-01
GO:BP GO:0071310 cellular response to organic substance 3 1390 8.93e-01
GO:BP GO:0007166 cell surface receptor signaling pathway 4 1889 8.95e-01
GO:BP GO:0009725 response to hormone 1 624 8.98e-01
GO:BP GO:0019725 cellular homeostasis 1 583 9.06e-01
GO:BP GO:0044087 regulation of cellular component biogenesis 1 802 9.10e-01
GO:BP GO:0007165 signal transduction 11 3803 9.12e-01
GO:BP GO:0009653 anatomical structure morphogenesis 4 1952 9.20e-01
GO:BP GO:0044237 cellular metabolic process 2 7562 9.21e-01
GO:BP GO:0050789 regulation of biological process 1 8017 9.25e-01
GO:BP GO:0016043 cellular component organization 2 5106 9.27e-01
GO:BP GO:0009605 response to external stimulus 2 1635 9.30e-01
GO:BP GO:0010033 response to organic substance 4 1942 9.31e-01
GO:BP GO:1901700 response to oxygen-containing compound 1 1219 9.34e-01
GO:BP GO:0071840 cellular component organization or biogenesis 2 5307 9.35e-01
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 1 868 9.40e-01
GO:BP GO:0010628 positive regulation of gene expression 1 795 9.41e-01
GO:BP GO:0065007 biological regulation 1 8282 9.50e-01
GO:BP GO:0006796 phosphate-containing compound metabolic process 3 2096 9.56e-01
GO:BP GO:0006793 phosphorus metabolic process 3 2118 9.58e-01
GO:BP GO:0000398 mRNA splicing, via spliceosome 1 288 9.63e-01
GO:BP GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 288 9.63e-01
GO:BP GO:0000375 RNA splicing, via transesterification reactions 1 292 9.63e-01
GO:BP GO:0051247 positive regulation of protein metabolic process 1 1067 9.63e-01
GO:BP GO:0008380 RNA splicing 2 426 9.64e-01
GO:BP GO:0006397 mRNA processing 2 451 9.67e-01
GO:BP GO:0016071 mRNA metabolic process 2 671 9.84e-01
GO:BP GO:0009987 cellular process 1 11410 1.00e+00
GO:BP GO:0006396 RNA processing 1 928 1.00e+00
GO:BP GO:0008150 biological_process 1 12027 1.00e+00
GO:BP GO:0008152 metabolic process 1 8522 1.00e+00
GO:BP GO:0071704 organic substance metabolic process 1 8176 1.00e+00
KEGG KEGG:05202 Transcriptional misregulation in cancer 4 128 8.80e-03
KEGG KEGG:05223 Non-small cell lung cancer 3 67 1.20e-02
KEGG KEGG:05222 Small cell lung cancer 3 87 1.53e-02
KEGG KEGG:05216 Thyroid cancer 2 35 1.53e-02
KEGG KEGG:05226 Gastric cancer 3 117 2.09e-02
KEGG KEGG:05212 Pancreatic cancer 2 75 2.09e-02
KEGG KEGG:05213 Endometrial cancer 2 57 2.09e-02
KEGG KEGG:05214 Glioma 2 67 2.09e-02
KEGG KEGG:05215 Prostate cancer 1 86 2.09e-02
KEGG KEGG:05217 Basal cell carcinoma 2 49 2.09e-02
KEGG KEGG:04115 p53 signaling pathway 2 65 2.09e-02
KEGG KEGG:05218 Melanoma 2 58 2.09e-02
KEGG KEGG:05220 Chronic myeloid leukemia 2 75 2.09e-02
KEGG KEGG:05210 Colorectal cancer 2 84 2.29e-02
KEGG KEGG:04064 NF-kappa B signaling pathway 2 71 2.96e-02
KEGG KEGG:04068 FoxO signaling pathway 2 109 4.44e-02
KEGG KEGG:04210 Apoptosis 2 118 4.44e-02
KEGG KEGG:00510 N-Glycan biosynthesis 1 48 4.62e-02
KEGG KEGG:05224 Breast cancer 2 117 4.66e-02
KEGG KEGG:04110 Cell cycle 2 151 4.77e-02
KEGG KEGG:04218 Cellular senescence 2 145 4.77e-02
KEGG KEGG:05225 Hepatocellular carcinoma 2 145 5.04e-02
KEGG KEGG:05169 Epstein-Barr virus infection 2 153 6.66e-02
KEGG KEGG:04710 Circadian rhythm 1 30 7.37e-02
KEGG KEGG:05016 Huntington disease 1 256 1.00e-01
KEGG KEGG:05014 Amyotrophic lateral sclerosis 1 303 1.14e-01
KEGG KEGG:04010 MAPK signaling pathway 2 240 1.14e-01
KEGG KEGG:05221 Acute myeloid leukemia 1 56 1.22e-01
KEGG KEGG:05022 Pathways of neurodegeneration - multiple diseases 1 385 1.32e-01
KEGG KEGG:04713 Circadian entrainment 1 69 1.56e-01
KEGG KEGG:05200 Pathways in cancer 3 409 1.56e-01
KEGG KEGG:04360 Axon guidance 1 162 1.77e-01
KEGG KEGG:04114 Oocyte meiosis 1 108 3.11e-01
KEGG KEGG:04080 Neuroactive ligand-receptor interaction 1 108 4.34e-01
KEGG KEGG:05206 MicroRNAs in cancer 1 149 5.30e-01
KEGG KEGG:01100 Metabolic pathways 1 1146 5.41e-01
KEGG KEGG:05168 Herpes simplex virus 1 infection 1 415 6.12e-01
KEGG KEGG:00000 KEGG root term 1 5548 6.12e-01
TRZnomtable %>%
  filter(source=="KEGG") %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "Enrichment of KEGG terms using nominal pvalue TRZ genes in my data") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")
Enrichment of KEGG terms using nominal pvalue TRZ genes in my data
source term_id term_name intersection_size term_size p_value
KEGG KEGG:05202 Transcriptional misregulation in cancer 4 128 8.80e-03
KEGG KEGG:05223 Non-small cell lung cancer 3 67 1.20e-02
KEGG KEGG:05222 Small cell lung cancer 3 87 1.53e-02
KEGG KEGG:05216 Thyroid cancer 2 35 1.53e-02
KEGG KEGG:05226 Gastric cancer 3 117 2.09e-02
KEGG KEGG:05212 Pancreatic cancer 2 75 2.09e-02
KEGG KEGG:05213 Endometrial cancer 2 57 2.09e-02
KEGG KEGG:05214 Glioma 2 67 2.09e-02
KEGG KEGG:05215 Prostate cancer 1 86 2.09e-02
KEGG KEGG:05217 Basal cell carcinoma 2 49 2.09e-02
KEGG KEGG:04115 p53 signaling pathway 2 65 2.09e-02
KEGG KEGG:05218 Melanoma 2 58 2.09e-02
KEGG KEGG:05220 Chronic myeloid leukemia 2 75 2.09e-02
KEGG KEGG:05210 Colorectal cancer 2 84 2.29e-02
KEGG KEGG:04064 NF-kappa B signaling pathway 2 71 2.96e-02
KEGG KEGG:04068 FoxO signaling pathway 2 109 4.44e-02
KEGG KEGG:04210 Apoptosis 2 118 4.44e-02
KEGG KEGG:00510 N-Glycan biosynthesis 1 48 4.62e-02
KEGG KEGG:05224 Breast cancer 2 117 4.66e-02
KEGG KEGG:04110 Cell cycle 2 151 4.77e-02
KEGG KEGG:04218 Cellular senescence 2 145 4.77e-02
KEGG KEGG:05225 Hepatocellular carcinoma 2 145 5.04e-02
KEGG KEGG:05169 Epstein-Barr virus infection 2 153 6.66e-02
KEGG KEGG:04710 Circadian rhythm 1 30 7.37e-02
KEGG KEGG:05016 Huntington disease 1 256 1.00e-01
KEGG KEGG:05014 Amyotrophic lateral sclerosis 1 303 1.14e-01
KEGG KEGG:04010 MAPK signaling pathway 2 240 1.14e-01
KEGG KEGG:05221 Acute myeloid leukemia 1 56 1.22e-01
KEGG KEGG:05022 Pathways of neurodegeneration - multiple diseases 1 385 1.32e-01
KEGG KEGG:04713 Circadian entrainment 1 69 1.56e-01
KEGG KEGG:05200 Pathways in cancer 3 409 1.56e-01
KEGG KEGG:04360 Axon guidance 1 162 1.77e-01
KEGG KEGG:04114 Oocyte meiosis 1 108 3.11e-01
KEGG KEGG:04080 Neuroactive ligand-receptor interaction 1 108 4.34e-01
KEGG KEGG:05206 MicroRNAs in cancer 1 149 5.30e-01
KEGG KEGG:01100 Metabolic pathways 1 1146 5.41e-01
KEGG KEGG:05168 Herpes simplex virus 1 infection 1 415 6.12e-01
KEGG KEGG:00000 KEGG root term 1 5548 6.12e-01

TRZ 3 hour nom de

# TRZresgenes3h <- gost(query = TRZ_list3h$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = TRUE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = backGL$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(TRZresgenes3h,"data/DEG-GO/TRZresgenes3h.RDS")
TRZresgenes3h <- readRDS("data/DEG-GO/TRZresgenes3h.RDS")

TRZnom3h <- gostplot(TRZresgenes3h, capped = FALSE, interactive = TRUE)
TRZnom3h
TRZnomtable3h <- TRZresgenes3h$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

TRZnomtable3h %>%
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")
source term_id term_name intersection_size term_size p_value
GO:BP GO:1900745 positive regulation of p38MAPK cascade 2 22 6.71e-03
GO:BP GO:1902746 regulation of lens fiber cell differentiation 2 8 6.71e-03
GO:BP GO:1902747 negative regulation of lens fiber cell differentiation 2 5 6.71e-03
GO:BP GO:0120162 positive regulation of cold-induced thermogenesis 2 72 8.98e-03
GO:BP GO:1900744 regulation of p38MAPK cascade 2 32 8.98e-03
GO:BP GO:0038066 p38MAPK cascade 2 42 1.06e-02
GO:BP GO:0010801 negative regulation of peptidyl-threonine phosphorylation 2 15 1.06e-02
GO:BP GO:0120161 regulation of cold-induced thermogenesis 2 115 1.12e-02
GO:BP GO:0106106 cold-induced thermogenesis 2 116 1.12e-02
GO:BP GO:1990845 adaptive thermogenesis 2 127 1.25e-02
GO:BP GO:0001659 temperature homeostasis 2 135 1.35e-02
GO:BP GO:0097167 circadian regulation of translation 1 4 1.51e-02
GO:BP GO:0010719 negative regulation of epithelial to mesenchymal transition 2 29 1.51e-02
GO:BP GO:0031400 negative regulation of protein modification process 4 396 1.51e-02
GO:BP GO:0019249 lactate biosynthetic process 1 3 1.51e-02
GO:BP GO:0001837 epithelial to mesenchymal transition 3 139 1.51e-02
GO:BP GO:0046330 positive regulation of JNK cascade 2 71 1.51e-02
GO:BP GO:0051941 regulation of amino acid uptake involved in synaptic transmission 1 3 1.51e-02
GO:BP GO:0051946 regulation of glutamate uptake involved in transmission of nerve impulse 1 3 1.51e-02
GO:BP GO:0070345 negative regulation of fat cell proliferation 1 4 1.51e-02
GO:BP GO:0070306 lens fiber cell differentiation 2 30 1.61e-02
GO:BP GO:0051935 glutamate reuptake 1 4 1.65e-02
GO:BP GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 2 97 1.74e-02
GO:BP GO:0032874 positive regulation of stress-activated MAPK cascade 2 95 1.74e-02
GO:BP GO:0010799 regulation of peptidyl-threonine phosphorylation 2 35 1.74e-02
GO:BP GO:0002036 regulation of L-glutamate import across plasma membrane 1 6 1.86e-02
GO:BP GO:0046328 regulation of JNK cascade 2 113 1.90e-02
GO:BP GO:0030857 negative regulation of epithelial cell differentiation 2 31 2.01e-02
GO:BP GO:0051933 amino acid neurotransmitter reuptake 1 5 2.01e-02
GO:BP GO:0070344 regulation of fat cell proliferation 1 8 2.01e-02
GO:BP GO:0042754 negative regulation of circadian rhythm 1 8 2.27e-02
GO:BP GO:0045210 FasL biosynthetic process 1 1 2.27e-02
GO:BP GO:0043065 positive regulation of apoptotic process 3 394 2.35e-02
GO:BP GO:0007254 JNK cascade 2 137 2.35e-02
GO:BP GO:1903789 regulation of amino acid transmembrane transport 1 14 2.39e-02
GO:BP GO:0048762 mesenchymal cell differentiation 3 205 2.39e-02
GO:BP GO:0070341 fat cell proliferation 1 11 2.39e-02
GO:BP GO:0010958 regulation of amino acid import across plasma membrane 1 14 2.39e-02
GO:BP GO:0070302 regulation of stress-activated protein kinase signaling cascade 2 157 2.39e-02
GO:BP GO:0043068 positive regulation of programmed cell death 3 403 2.39e-02
GO:BP GO:0032872 regulation of stress-activated MAPK cascade 2 153 2.39e-02
GO:BP GO:0098712 L-glutamate import across plasma membrane 1 11 2.44e-02
GO:BP GO:0050872 white fat cell differentiation 1 15 2.44e-02
GO:BP GO:0070373 negative regulation of ERK1 and ERK2 cascade 2 58 2.44e-02
GO:BP GO:0000271 polysaccharide biosynthetic process 2 54 2.44e-02
GO:BP GO:0051580 regulation of neurotransmitter uptake 1 15 2.44e-02
GO:BP GO:2000678 negative regulation of transcription regulatory region DNA binding 1 17 2.44e-02
GO:BP GO:0043408 regulation of MAPK cascade 4 473 2.47e-02
GO:BP GO:0006089 lactate metabolic process 1 16 2.47e-02
GO:BP GO:0001933 negative regulation of protein phosphorylation 3 265 2.73e-02
GO:BP GO:0043153 entrainment of circadian clock by photoperiod 1 23 2.79e-02
GO:BP GO:0051403 stress-activated MAPK cascade 2 188 2.79e-02
GO:BP GO:0031098 stress-activated protein kinase signaling cascade 2 194 2.89e-02
GO:BP GO:0031397 negative regulation of protein ubiquitination 2 76 2.97e-02
GO:BP GO:0009648 photoperiodism 1 24 2.97e-02
GO:BP GO:0015813 L-glutamate transmembrane transport 1 18 2.99e-02
GO:BP GO:0009649 entrainment of circadian clock 1 27 2.99e-02
GO:BP GO:0051726 regulation of cell cycle 3 941 2.99e-02
GO:BP GO:0042326 negative regulation of phosphorylation 3 290 2.99e-02
GO:BP GO:0060485 mesenchyme development 3 250 3.09e-02
GO:BP GO:0002088 lens development in camera-type eye 2 57 3.09e-02
GO:BP GO:1900623 regulation of monocyte aggregation 1 3 3.11e-02
GO:BP GO:0045226 extracellular polysaccharide biosynthetic process 1 2 3.11e-02
GO:BP GO:0098810 neurotransmitter reuptake 1 21 3.11e-02
GO:BP GO:0046379 extracellular polysaccharide metabolic process 1 2 3.11e-02
GO:BP GO:0051938 L-glutamate import 1 24 3.11e-02
GO:BP GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 2 85 3.11e-02
GO:BP GO:1900625 positive regulation of monocyte aggregation 1 3 3.11e-02
GO:BP GO:0000165 MAPK cascade 4 553 3.11e-02
GO:BP GO:1903321 negative regulation of protein modification by small protein conjugation or removal 2 86 3.11e-02
GO:BP GO:0010717 regulation of epithelial to mesenchymal transition 2 87 3.20e-02
GO:BP GO:0010563 negative regulation of phosphorus metabolic process 3 335 3.45e-02
GO:BP GO:0009250 glucan biosynthetic process 1 40 3.45e-02
GO:BP GO:0018107 peptidyl-threonine phosphorylation 2 96 3.45e-02
GO:BP GO:0045936 negative regulation of phosphate metabolic process 3 334 3.45e-02
GO:BP GO:0001504 neurotransmitter uptake 1 29 3.45e-02
GO:BP GO:0005978 glycogen biosynthetic process 1 40 3.45e-02
GO:BP GO:0051955 regulation of amino acid transport 1 28 3.45e-02
GO:BP GO:0005976 polysaccharide metabolic process 2 81 3.45e-02
GO:BP GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway 1 3 3.45e-02
GO:BP GO:1901874 negative regulation of post-translational protein modification 2 98 3.45e-02
GO:BP GO:0048871 multicellular organismal-level homeostasis 2 570 3.48e-02
GO:BP GO:0043392 negative regulation of DNA binding 1 44 3.48e-02
GO:BP GO:1900127 positive regulation of hyaluronan biosynthetic process 1 4 3.48e-02
GO:BP GO:0090500 endocardial cushion to mesenchymal transition 1 4 3.48e-02
GO:BP GO:0089718 amino acid import across plasma membrane 1 38 3.51e-02
GO:BP GO:0000379 tRNA-type intron splice site recognition and cleavage 1 3 3.54e-02
GO:BP GO:2000677 regulation of transcription regulatory region DNA binding 1 43 3.57e-02
GO:BP GO:0018210 peptidyl-threonine modification 2 103 3.61e-02
GO:BP GO:0060437 lung growth 1 4 3.69e-02
GO:BP GO:0002931 response to ischemia 1 48 3.92e-02
GO:BP GO:0070487 monocyte aggregation 1 4 3.93e-02
GO:BP GO:0015800 acidic amino acid transport 1 39 4.03e-02
GO:BP GO:0019229 regulation of vasoconstriction 1 38 4.05e-02
GO:BP GO:0034089 establishment of meiotic sister chromatid cohesion 1 4 4.06e-02
GO:BP GO:1901842 negative regulation of high voltage-gated calcium channel activity 1 4 4.08e-02
GO:BP GO:1902475 L-alpha-amino acid transmembrane transport 1 51 4.30e-02
GO:BP GO:0032922 circadian regulation of gene expression 1 63 4.32e-02
GO:BP GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 2 126 4.34e-02
GO:BP GO:0070295 renal water absorption 1 6 4.34e-02
GO:BP GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 2 127 4.35e-02
GO:BP GO:0005977 glycogen metabolic process 1 64 4.35e-02
GO:BP GO:0060449 bud elongation involved in lung branching 1 7 4.35e-02
GO:BP GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 2 122 4.35e-02
GO:BP GO:1902533 positive regulation of intracellular signal transduction 4 707 4.35e-02
GO:BP GO:0060349 bone morphogenesis 2 74 4.35e-02
GO:BP GO:0032890 regulation of organic acid transport 1 48 4.35e-02
GO:BP GO:0044042 glucan metabolic process 1 65 4.35e-02
GO:BP GO:0043410 positive regulation of MAPK cascade 3 316 4.41e-02
GO:BP GO:0051248 negative regulation of protein metabolic process 4 799 4.41e-02
GO:BP GO:0042310 vasoconstriction 1 51 4.46e-02
GO:BP GO:1900125 regulation of hyaluronan biosynthetic process 1 6 4.52e-02
GO:BP GO:0015807 L-amino acid transport 1 62 4.53e-02
GO:BP GO:0030856 regulation of epithelial cell differentiation 2 100 4.53e-02
GO:BP GO:0006112 energy reserve metabolic process 1 72 4.53e-02
GO:BP GO:0006094 gluconeogenesis 1 70 4.53e-02
GO:BP GO:0019319 hexose biosynthetic process 1 73 4.65e-02
GO:BP GO:0030010 establishment of cell polarity 2 135 4.72e-02
GO:BP GO:0006835 dicarboxylic acid transport 1 61 4.72e-02
GO:BP GO:0051588 regulation of neurotransmitter transport 1 71 4.83e-02
GO:BP GO:0051952 regulation of amine transport 1 56 4.84e-02
GO:BP GO:0046364 monosaccharide biosynthetic process 1 82 4.90e-02
GO:BP GO:0003333 amino acid transmembrane transport 1 70 4.91e-02
GO:BP GO:0080135 regulation of cellular response to stress 3 585 5.05e-02
GO:BP GO:0043409 negative regulation of MAPK cascade 2 145 5.14e-02
GO:BP GO:0003097 renal water transport 1 7 5.14e-02
GO:BP GO:0015837 amine transport 1 59 5.14e-02
GO:BP GO:0042752 regulation of circadian rhythm 1 93 5.33e-02
GO:BP GO:0007049 cell cycle 3 1515 5.42e-02
GO:BP GO:0051101 regulation of DNA binding 1 102 5.53e-02
GO:BP GO:0001654 eye development 3 273 5.66e-02
GO:BP GO:0150063 visual system development 3 274 5.77e-02
GO:BP GO:0048880 sensory system development 3 276 5.88e-02
GO:BP GO:0051386 regulation of neurotrophin TRK receptor signaling pathway 1 11 5.88e-02
GO:BP GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway 1 8 5.88e-02
GO:BP GO:0044092 negative regulation of molecular function 4 730 6.19e-02
GO:BP GO:0035296 regulation of tube diameter 1 98 6.19e-02
GO:BP GO:0097746 blood vessel diameter maintenance 1 98 6.19e-02
GO:BP GO:0051549 positive regulation of keratinocyte migration 1 11 6.19e-02
GO:BP GO:0035150 regulation of tube size 1 98 6.19e-02
GO:BP GO:0006469 negative regulation of protein kinase activity 2 173 6.21e-02
GO:BP GO:0006865 amino acid transport 1 103 6.21e-02
GO:BP GO:1905039 carboxylic acid transmembrane transport 1 111 6.25e-02
GO:BP GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus 1 10 6.25e-02
GO:BP GO:0030213 hyaluronan biosynthetic process 1 10 6.25e-02
GO:BP GO:0035810 positive regulation of urine volume 1 10 6.25e-02
GO:BP GO:0036302 atrioventricular canal development 1 12 6.25e-02
GO:BP GO:0007179 transforming growth factor beta receptor signaling pathway 2 177 6.25e-02
GO:BP GO:0070486 leukocyte aggregation 1 9 6.25e-02
GO:BP GO:1903825 organic acid transmembrane transport 1 112 6.25e-02
GO:BP GO:0051100 negative regulation of binding 1 133 6.32e-02
GO:BP GO:0034085 establishment of sister chromatid cohesion 1 10 6.33e-02
GO:BP GO:0050796 regulation of insulin secretion 1 119 6.54e-02
GO:BP GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator 1 16 6.54e-02
GO:BP GO:0010838 positive regulation of keratinocyte proliferation 1 9 6.54e-02
GO:BP GO:0031396 regulation of protein ubiquitination 2 194 6.54e-02
GO:BP GO:1901841 regulation of high voltage-gated calcium channel activity 1 12 6.54e-02
GO:BP GO:0051547 regulation of keratinocyte migration 1 13 6.54e-02
GO:BP GO:0033673 negative regulation of kinase activity 2 191 6.67e-02
GO:BP GO:0035265 organ growth 2 128 6.71e-02
GO:BP GO:0044849 estrous cycle 1 14 6.72e-02
GO:BP GO:0001505 regulation of neurotransmitter levels 1 132 6.90e-02
GO:BP GO:0006006 glucose metabolic process 1 153 6.97e-02
GO:BP GO:0016051 carbohydrate biosynthetic process 2 160 6.99e-02
GO:BP GO:1901201 regulation of extracellular matrix assembly 1 15 6.99e-02
GO:BP GO:0007163 establishment or maintenance of cell polarity 2 197 7.06e-02
GO:BP GO:0051240 positive regulation of multicellular organismal process 2 1103 7.06e-02
GO:BP GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway 1 16 7.08e-02
GO:BP GO:0098739 import across plasma membrane 1 130 7.12e-02
GO:BP GO:0090276 regulation of peptide hormone secretion 1 135 7.12e-02
GO:BP GO:0006836 neurotransmitter transport 1 141 7.12e-02
GO:BP GO:0002791 regulation of peptide secretion 1 137 7.12e-02
GO:BP GO:0030073 insulin secretion 1 144 7.12e-02
GO:BP GO:0007623 circadian rhythm 1 160 7.12e-02
GO:BP GO:0090087 regulation of peptide transport 1 139 7.15e-02
GO:BP GO:0042592 homeostatic process 2 1189 7.33e-02
GO:BP GO:0072330 monocarboxylic acid biosynthetic process 1 146 7.34e-02
GO:BP GO:0060602 branch elongation of an epithelium 1 15 7.41e-02
GO:BP GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation 1 13 7.41e-02
GO:BP GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 2 211 7.42e-02
GO:BP GO:0055012 ventricular cardiac muscle cell differentiation 1 15 7.42e-02
GO:BP GO:0051177 meiotic sister chromatid cohesion 1 11 7.42e-02
GO:BP GO:0045444 fat cell differentiation 1 187 7.54e-02
GO:BP GO:0071560 cellular response to transforming growth factor beta stimulus 2 222 7.54e-02
GO:BP GO:0019318 hexose metabolic process 1 187 7.54e-02
GO:BP GO:0051546 keratinocyte migration 1 15 7.54e-02
GO:BP GO:0071498 cellular response to fluid shear stress 1 19 7.54e-02
GO:BP GO:0042981 regulation of apoptotic process 5 1092 7.54e-02
GO:BP GO:0051348 negative regulation of transferase activity 2 225 7.54e-02
GO:BP GO:1901617 organic hydroxy compound biosynthetic process 1 174 7.54e-02
GO:BP GO:1903320 regulation of protein modification by small protein conjugation or removal 2 232 7.54e-02
GO:BP GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation 1 14 7.54e-02
GO:BP GO:0071559 response to transforming growth factor beta 2 227 7.61e-02
GO:BP GO:1900746 regulation of vascular endothelial growth factor signaling pathway 1 18 7.61e-02
GO:BP GO:0036120 cellular response to platelet-derived growth factor stimulus 1 20 7.61e-02
GO:BP GO:0030072 peptide hormone secretion 1 169 7.61e-02
GO:BP GO:1903522 regulation of blood circulation 1 197 7.61e-02
GO:BP GO:0002790 peptide secretion 1 173 7.61e-02
GO:BP GO:0035809 regulation of urine volume 1 14 7.61e-02
GO:BP GO:1901386 negative regulation of voltage-gated calcium channel activity 1 14 7.61e-02
GO:BP GO:0046883 regulation of hormone secretion 1 171 7.76e-02
GO:BP GO:0005996 monosaccharide metabolic process 1 212 7.77e-02
GO:BP GO:0071363 cellular response to growth factor stimulus 3 549 7.77e-02
GO:BP GO:0003018 vascular process in circulatory system 1 198 7.77e-02
GO:BP GO:0050708 regulation of protein secretion 1 186 7.77e-02
GO:BP GO:0043067 regulation of programmed cell death 5 1124 7.77e-02
GO:BP GO:0015833 peptide transport 1 182 7.81e-02
GO:BP GO:0031399 regulation of protein modification process 4 1096 7.81e-02
GO:BP GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus 1 20 7.83e-02
GO:BP GO:0048011 neurotrophin TRK receptor signaling pathway 1 23 7.83e-02
GO:BP GO:0036119 response to platelet-derived growth factor 1 22 7.83e-02
GO:BP GO:0090162 establishment of epithelial cell polarity 1 30 7.91e-02
GO:BP GO:0003417 growth plate cartilage development 1 14 8.01e-02
GO:BP GO:1901798 positive regulation of signal transduction by p53 class mediator 1 28 8.02e-02
GO:BP GO:0003091 renal water homeostasis 1 14 8.02e-02
GO:BP GO:0070848 response to growth factor 3 571 8.31e-02
GO:BP GO:0048511 rhythmic process 1 233 8.33e-02
GO:BP GO:0043950 positive regulation of cAMP-mediated signaling 1 5 8.40e-02
GO:BP GO:0009416 response to light stimulus 1 241 8.56e-02
GO:BP GO:0070372 regulation of ERK1 and ERK2 cascade 2 192 8.56e-02
GO:BP GO:0016567 protein ubiquitination 3 684 8.56e-02
GO:BP GO:0046879 hormone secretion 1 212 8.56e-02
GO:BP GO:0034260 negative regulation of GTPase activity 1 25 8.56e-02
GO:BP GO:0060348 bone development 2 157 8.58e-02
GO:BP GO:0060441 epithelial tube branching involved in lung morphogenesis 1 21 8.58e-02
GO:BP GO:0021756 striatum development 1 18 8.58e-02
GO:BP GO:0016053 organic acid biosynthetic process 1 224 8.58e-02
GO:BP GO:0046394 carboxylic acid biosynthetic process 1 223 8.58e-02
GO:BP GO:0009914 hormone transport 1 217 8.58e-02
GO:BP GO:2000647 negative regulation of stem cell proliferation 1 18 8.58e-02
GO:BP GO:1901873 regulation of post-translational protein modification 1 302 8.66e-02
GO:BP GO:0003401 axis elongation 1 25 8.75e-02
GO:BP GO:0015980 energy derivation by oxidation of organic compounds 1 288 8.75e-02
GO:BP GO:0140013 meiotic nuclear division 2 117 8.80e-02
GO:BP GO:0090287 regulation of cellular response to growth factor stimulus 2 261 8.80e-02
GO:BP GO:0006833 water transport 1 12 8.80e-02
GO:BP GO:0015849 organic acid transport 1 214 8.80e-02
GO:BP GO:0046942 carboxylic acid transport 1 213 8.80e-02
GO:BP GO:0040036 regulation of fibroblast growth factor receptor signaling pathway 1 25 8.80e-02
GO:BP GO:0009306 protein secretion 1 262 8.92e-02
GO:BP GO:0051098 regulation of binding 1 314 8.92e-02
GO:BP GO:0048705 skeletal system morphogenesis 2 155 8.92e-02
GO:BP GO:0009967 positive regulation of signal transduction 4 1116 8.92e-02
GO:BP GO:0042886 amide transport 1 237 8.92e-02
GO:BP GO:0035592 establishment of protein localization to extracellular region 1 262 8.92e-02
GO:BP GO:0007423 sensory organ development 3 395 8.92e-02
GO:BP GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator 1 36 8.92e-02
GO:BP GO:0070371 ERK1 and ERK2 cascade 2 211 8.92e-02
GO:BP GO:0070293 renal absorption 1 24 8.92e-02
GO:BP GO:0032331 negative regulation of chondrocyte differentiation 1 18 8.95e-02
GO:BP GO:0071692 protein localization to extracellular region 1 266 8.98e-02
GO:BP GO:0007130 synaptonemal complex assembly 1 10 9.09e-02
GO:BP GO:0050767 regulation of neurogenesis 1 302 9.15e-02
GO:BP GO:0050891 multicellular organismal-level water homeostasis 1 17 9.23e-02
GO:BP GO:0060317 cardiac epithelial to mesenchymal transition 1 28 9.23e-02
GO:BP GO:0030212 hyaluronan metabolic process 1 21 9.23e-02
GO:BP GO:0006631 fatty acid metabolic process 1 276 9.31e-02
GO:BP GO:0032446 protein modification by small protein conjugation 3 759 9.36e-02
GO:BP GO:0034405 response to fluid shear stress 1 31 9.36e-02
GO:BP GO:0000132 establishment of mitotic spindle orientation 1 32 9.36e-02
GO:BP GO:1903046 meiotic cell cycle process 2 132 9.48e-02
GO:BP GO:0021544 subpallium development 1 19 9.48e-02
GO:BP GO:0035116 embryonic hindlimb morphogenesis 1 17 9.48e-02
GO:BP GO:0003416 endochondral bone growth 1 22 9.48e-02
GO:BP GO:0006417 regulation of translation 1 373 9.51e-02
GO:BP GO:0038179 neurotrophin signaling pathway 1 36 9.51e-02
GO:BP GO:0070193 synaptonemal complex organization 1 13 9.51e-02
GO:BP GO:0090311 regulation of protein deacetylation 1 44 9.51e-02
GO:BP GO:0043010 camera-type eye development 2 237 9.51e-02
GO:BP GO:0009314 response to radiation 1 339 9.51e-02
GO:BP GO:0032885 regulation of polysaccharide biosynthetic process 1 32 9.51e-02
GO:BP GO:0015711 organic anion transport 1 270 9.66e-02
GO:BP GO:0042044 fluid transport 1 19 9.94e-02
GO:BP GO:0098868 bone growth 1 23 1.01e-01
GO:BP GO:0061037 negative regulation of cartilage development 1 23 1.01e-01
GO:BP GO:0014911 positive regulation of smooth muscle cell migration 1 32 1.01e-01
GO:BP GO:0051960 regulation of nervous system development 1 357 1.01e-01
GO:BP GO:0040001 establishment of mitotic spindle localization 1 37 1.01e-01
GO:BP GO:0038084 vascular endothelial growth factor signaling pathway 1 35 1.01e-01
GO:BP GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 2 298 1.02e-01
GO:BP GO:0051294 establishment of spindle orientation 1 37 1.02e-01
GO:BP GO:0034248 regulation of amide metabolic process 1 426 1.02e-01
GO:BP GO:0048566 embryonic digestive tract development 1 20 1.03e-01
GO:BP GO:1901020 negative regulation of calcium ion transmembrane transporter activity 1 28 1.03e-01
GO:BP GO:0023061 signal release 1 329 1.03e-01
GO:BP GO:0045596 negative regulation of cell differentiation 3 471 1.03e-01
GO:BP GO:0048384 retinoic acid receptor signaling pathway 1 27 1.03e-01
GO:BP GO:0032881 regulation of polysaccharide metabolic process 1 35 1.03e-01
GO:BP GO:0085029 extracellular matrix assembly 1 36 1.03e-01
GO:BP GO:1900026 positive regulation of substrate adhesion-dependent cell spreading 1 37 1.03e-01
GO:BP GO:0060351 cartilage development involved in endochondral bone morphogenesis 1 25 1.04e-01
GO:BP GO:0008015 blood circulation 1 372 1.04e-01
GO:BP GO:0090066 regulation of anatomical structure size 1 395 1.05e-01
GO:BP GO:0051223 regulation of protein transport 1 404 1.05e-01
GO:BP GO:0006091 generation of precursor metabolites and energy 1 423 1.05e-01
GO:BP GO:0048048 embryonic eye morphogenesis 1 25 1.05e-01
GO:BP GO:1902531 regulation of intracellular signal transduction 4 1318 1.06e-01
GO:BP GO:0002068 glandular epithelial cell development 1 28 1.06e-01
GO:BP GO:0035137 hindlimb morphogenesis 1 21 1.06e-01
GO:BP GO:0010837 regulation of keratinocyte proliferation 1 33 1.06e-01
GO:BP GO:0090596 sensory organ morphogenesis 2 179 1.06e-01
GO:BP GO:0006915 apoptotic process 3 1452 1.08e-01
GO:BP GO:0046580 negative regulation of Ras protein signal transduction 1 46 1.08e-01
GO:BP GO:0070201 regulation of establishment of protein localization 1 428 1.08e-01
GO:BP GO:0010817 regulation of hormone levels 1 337 1.08e-01
GO:BP GO:1901385 regulation of voltage-gated calcium channel activity 1 29 1.08e-01
GO:BP GO:0044057 regulation of system process 1 398 1.08e-01
GO:BP GO:0023056 positive regulation of signaling 4 1252 1.09e-01
GO:BP GO:0010647 positive regulation of cell communication 4 1249 1.09e-01
GO:BP GO:1901615 organic hydroxy compound metabolic process 1 375 1.09e-01
GO:BP GO:0043949 regulation of cAMP-mediated signaling 1 17 1.09e-01
GO:BP GO:1903530 regulation of secretion by cell 1 382 1.09e-01
GO:BP GO:0060425 lung morphogenesis 1 39 1.10e-01
GO:BP GO:0005975 carbohydrate metabolic process 1 439 1.10e-01
GO:BP GO:0048562 embryonic organ morphogenesis 2 186 1.10e-01
GO:BP GO:0030855 epithelial cell differentiation 3 439 1.10e-01
GO:BP GO:0040020 regulation of meiotic nuclear division 1 19 1.11e-01
GO:BP GO:0044283 small molecule biosynthetic process 1 432 1.11e-01
GO:BP GO:2001258 negative regulation of cation channel activity 1 31 1.11e-01
GO:BP GO:0003013 circulatory system process 1 445 1.11e-01
GO:BP GO:0001932 regulation of protein phosphorylation 3 758 1.11e-01
GO:BP GO:0034762 regulation of transmembrane transport 1 392 1.11e-01
GO:BP GO:0012501 programmed cell death 3 1498 1.12e-01
GO:BP GO:0070647 protein modification by small protein conjugation or removal 3 870 1.12e-01
GO:BP GO:0008219 cell death 3 1504 1.12e-01
GO:BP GO:0051058 negative regulation of small GTPase mediated signal transduction 1 52 1.14e-01
GO:BP GO:0051046 regulation of secretion 1 413 1.14e-01
GO:BP GO:1903170 negative regulation of calcium ion transmembrane transport 1 35 1.14e-01
GO:BP GO:0032787 monocarboxylic acid metabolic process 1 434 1.14e-01
GO:BP GO:0043407 negative regulation of MAP kinase activity 1 50 1.14e-01
GO:BP GO:0001822 kidney development 2 246 1.16e-01
GO:BP GO:0051293 establishment of spindle localization 1 49 1.18e-01
GO:BP GO:0051239 regulation of multicellular organismal process 2 2052 1.18e-01
GO:BP GO:0006338 chromatin remodeling 1 520 1.18e-01
GO:BP GO:0031641 regulation of myelination 1 35 1.19e-01
GO:BP GO:0072001 renal system development 2 253 1.20e-01
GO:BP GO:1903053 regulation of extracellular matrix organization 1 47 1.20e-01
GO:BP GO:0043616 keratinocyte proliferation 1 39 1.20e-01
GO:BP GO:0035924 cellular response to vascular endothelial growth factor stimulus 1 54 1.21e-01
GO:BP GO:0030330 DNA damage response, signal transduction by p53 class mediator 1 70 1.22e-01
GO:BP GO:0023051 regulation of signaling 3 2560 1.22e-01
GO:BP GO:0010646 regulation of cell communication 3 2567 1.23e-01
GO:BP GO:0051653 spindle localization 1 53 1.23e-01
GO:BP GO:0051321 meiotic cell cycle 2 183 1.24e-01
GO:BP GO:1900024 regulation of substrate adhesion-dependent cell spreading 1 54 1.25e-01
GO:BP GO:0002066 columnar/cuboidal epithelial cell development 1 39 1.30e-01
GO:BP GO:0006476 protein deacetylation 1 81 1.31e-01
GO:BP GO:0042325 regulation of phosphorylation 3 841 1.31e-01
GO:BP GO:0006412 translation 1 657 1.32e-01
GO:BP GO:0014910 regulation of smooth muscle cell migration 1 57 1.33e-01
GO:BP GO:0032330 regulation of chondrocyte differentiation 1 36 1.33e-01
GO:BP GO:0080134 regulation of response to stress 2 1074 1.34e-01
GO:BP GO:0043043 peptide biosynthetic process 1 677 1.35e-01
GO:BP GO:0006325 chromatin organization 1 631 1.35e-01
GO:BP GO:0032940 secretion by cell 1 573 1.39e-01
GO:BP GO:2000026 regulation of multicellular organismal development 4 997 1.39e-01
GO:BP GO:0051926 negative regulation of calcium ion transport 1 45 1.39e-01
GO:BP GO:0006024 glycosaminoglycan biosynthetic process 1 59 1.40e-01
GO:BP GO:0060284 regulation of cell development 1 593 1.41e-01
GO:BP GO:0007129 homologous chromosome pairing at meiosis 1 24 1.41e-01
GO:BP GO:0042698 ovulation cycle 1 54 1.41e-01
GO:BP GO:0006023 aminoglycan biosynthetic process 1 61 1.41e-01
GO:BP GO:0014909 smooth muscle cell migration 1 64 1.41e-01
GO:BP GO:0035601 protein deacylation 1 91 1.41e-01
GO:BP GO:0008543 fibroblast growth factor receptor signaling pathway 1 59 1.42e-01
GO:BP GO:0098732 macromolecule deacylation 1 92 1.42e-01
GO:BP GO:0140962 multicellular organismal-level chemical homeostasis 1 48 1.42e-01
GO:BP GO:0008285 negative regulation of cell population proliferation 1 643 1.42e-01
GO:BP GO:0060350 endochondral bone morphogenesis 1 47 1.43e-01
GO:BP GO:0071824 protein-DNA complex organization 1 711 1.43e-01
GO:BP GO:1902532 negative regulation of intracellular signal transduction 2 445 1.43e-01
GO:BP GO:0032880 regulation of protein localization 1 719 1.43e-01
GO:BP GO:0140352 export from cell 1 617 1.43e-01
GO:BP GO:0007062 sister chromatid cohesion 1 52 1.43e-01
GO:BP GO:0045913 positive regulation of carbohydrate metabolic process 1 61 1.44e-01
GO:BP GO:0006518 peptide metabolic process 1 781 1.47e-01
GO:BP GO:0043604 amide biosynthetic process 1 785 1.49e-01
GO:BP GO:0071495 cellular response to endogenous stimulus 4 1097 1.49e-01
GO:BP GO:0098657 import into cell 1 664 1.50e-01
GO:BP GO:0032413 negative regulation of ion transmembrane transporter activity 1 52 1.50e-01
GO:BP GO:0019752 carboxylic acid metabolic process 1 684 1.50e-01
GO:BP GO:1901796 regulation of signal transduction by p53 class mediator 1 102 1.50e-01
GO:BP GO:0046903 secretion 1 647 1.51e-01
GO:BP GO:0006082 organic acid metabolic process 1 703 1.52e-01
GO:BP GO:0043436 oxoacid metabolic process 1 699 1.52e-01
GO:BP GO:0001570 vasculogenesis 1 67 1.52e-01
GO:BP GO:0000122 negative regulation of transcription by RNA polymerase II 1 744 1.52e-01
GO:BP GO:0019933 cAMP-mediated signaling 1 35 1.52e-01
GO:BP GO:0060341 regulation of cellular localization 1 805 1.53e-01
GO:BP GO:0014812 muscle cell migration 1 75 1.55e-01
GO:BP GO:0045143 homologous chromosome segregation 1 32 1.55e-01
GO:BP GO:0044255 cellular lipid metabolic process 1 736 1.55e-01
GO:BP GO:0051174 regulation of phosphorus metabolic process 3 950 1.55e-01
GO:BP GO:0019220 regulation of phosphate metabolic process 3 949 1.55e-01
GO:BP GO:0006950 response to stress 3 2763 1.55e-01
GO:BP GO:0070192 chromosome organization involved in meiotic cell cycle 1 35 1.55e-01
GO:BP GO:0032410 negative regulation of transporter activity 1 59 1.58e-01
GO:BP GO:0061035 regulation of cartilage development 1 53 1.58e-01
GO:BP GO:0043687 post-translational protein modification 3 1102 1.58e-01
GO:BP GO:0051093 negative regulation of developmental process 3 654 1.58e-01
GO:BP GO:0033554 cellular response to stress 4 1662 1.59e-01
GO:BP GO:0051480 regulation of cytosolic calcium ion concentration 1 39 1.59e-01
GO:BP GO:0009893 positive regulation of metabolic process 2 2846 1.59e-01
GO:BP GO:0016525 negative regulation of angiogenesis 1 71 1.59e-01
GO:BP GO:0007264 small GTPase mediated signal transduction 2 413 1.59e-01
GO:BP GO:0002067 glandular epithelial cell differentiation 1 49 1.59e-01
GO:BP GO:0030335 positive regulation of cell migration 2 408 1.59e-01
GO:BP GO:2000181 negative regulation of blood vessel morphogenesis 1 72 1.60e-01
GO:BP GO:0090288 negative regulation of cellular response to growth factor stimulus 1 80 1.60e-01
GO:BP GO:1901343 negative regulation of vasculature development 1 72 1.60e-01
GO:BP GO:0010608 post-transcriptional regulation of gene expression 1 475 1.60e-01
GO:BP GO:0009628 response to abiotic stimulus 1 848 1.61e-01
GO:BP GO:0051445 regulation of meiotic cell cycle 1 45 1.61e-01
GO:BP GO:1904063 negative regulation of cation transmembrane transport 1 64 1.61e-01
GO:BP GO:1990823 response to leukemia inhibitory factor 1 87 1.61e-01
GO:BP GO:1990830 cellular response to leukemia inhibitory factor 1 86 1.61e-01
GO:BP GO:1903510 mucopolysaccharide metabolic process 1 75 1.61e-01
GO:BP GO:0071901 negative regulation of protein serine/threonine kinase activity 1 96 1.63e-01
GO:BP GO:0045859 regulation of protein kinase activity 2 473 1.63e-01
GO:BP GO:0044344 cellular response to fibroblast growth factor stimulus 1 81 1.63e-01
GO:BP GO:0033138 positive regulation of peptidyl-serine phosphorylation 1 68 1.63e-01
GO:BP GO:0042472 inner ear morphogenesis 1 59 1.63e-01
GO:BP GO:0043255 regulation of carbohydrate biosynthetic process 1 79 1.63e-01
GO:BP GO:0045595 regulation of cell differentiation 4 1122 1.64e-01
GO:BP GO:2000147 positive regulation of cell motility 2 421 1.64e-01
GO:BP GO:0034446 substrate adhesion-dependent cell spreading 1 90 1.64e-01
GO:BP GO:0043086 negative regulation of catalytic activity 2 456 1.64e-01
GO:BP GO:0035556 intracellular signal transduction 5 2036 1.65e-01
GO:BP GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 1 78 1.65e-01
GO:BP GO:1901019 regulation of calcium ion transmembrane transporter activity 1 70 1.67e-01
GO:BP GO:0071774 response to fibroblast growth factor 1 85 1.69e-01
GO:BP GO:0043603 amide metabolic process 1 1003 1.69e-01
GO:BP GO:0034766 negative regulation of monoatomic ion transmembrane transport 1 70 1.69e-01
GO:BP GO:0040017 positive regulation of locomotion 2 429 1.69e-01
GO:BP GO:0048584 positive regulation of response to stimulus 4 1557 1.69e-01
GO:BP GO:0048568 embryonic organ development 2 314 1.69e-01
GO:BP GO:0071347 cellular response to interleukin-1 1 64 1.69e-01
GO:BP GO:0072091 regulation of stem cell proliferation 1 58 1.74e-01
GO:BP GO:0045892 negative regulation of DNA-templated transcription 1 1005 1.80e-01
GO:BP GO:0048869 cellular developmental process 3 2943 1.81e-01
GO:BP GO:0030154 cell differentiation 3 2942 1.81e-01
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 1 1014 1.81e-01
GO:BP GO:0030203 glycosaminoglycan metabolic process 1 87 1.81e-01
GO:BP GO:0045132 meiotic chromosome segregation 1 51 1.83e-01
GO:BP GO:0042471 ear morphogenesis 1 73 1.84e-01
GO:BP GO:0048514 blood vessel morphogenesis 2 461 1.86e-01
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 5 1832 1.88e-01
GO:BP GO:0003014 renal system process 1 76 1.89e-01
GO:BP GO:0006629 lipid metabolic process 1 989 1.89e-01
GO:BP GO:0009887 animal organ morphogenesis 3 725 1.90e-01
GO:BP GO:0010811 positive regulation of cell-substrate adhesion 1 99 1.90e-01
GO:BP GO:0001657 ureteric bud development 1 75 1.90e-01
GO:BP GO:0006022 aminoglycan metabolic process 1 92 1.90e-01
GO:BP GO:0072163 mesonephric epithelium development 1 76 1.91e-01
GO:BP GO:0051253 negative regulation of RNA metabolic process 1 1112 1.91e-01
GO:BP GO:0072164 mesonephric tubule development 1 76 1.91e-01
GO:BP GO:0009719 response to endogenous stimulus 4 1260 1.92e-01
GO:BP GO:0033135 regulation of peptidyl-serine phosphorylation 1 97 1.92e-01
GO:BP GO:0043549 regulation of kinase activity 2 548 1.92e-01
GO:BP GO:0019935 cyclic-nucleotide-mediated signaling 1 52 1.92e-01
GO:BP GO:0001823 mesonephros development 1 77 1.96e-01
GO:BP GO:0070555 response to interleukin-1 1 82 1.97e-01
GO:BP GO:0051246 regulation of protein metabolic process 4 1895 1.98e-01
GO:BP GO:0006468 protein phosphorylation 3 1130 1.98e-01
GO:BP GO:0035295 tube development 3 822 1.98e-01
GO:BP GO:0001501 skeletal system development 2 361 1.98e-01
GO:BP GO:0000280 nuclear division 2 343 1.98e-01
GO:BP GO:1901137 carbohydrate derivative biosynthetic process 2 544 1.98e-01
GO:BP GO:0072331 signal transduction by p53 class mediator 1 163 1.98e-01
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 1 1203 2.00e-01
GO:BP GO:0043271 negative regulation of monoatomic ion transport 1 88 2.00e-01
GO:BP GO:0034763 negative regulation of transmembrane transport 1 96 2.00e-01
GO:BP GO:0036211 protein modification process 5 2751 2.01e-01
GO:BP GO:0051241 negative regulation of multicellular organismal process 3 744 2.01e-01
GO:BP GO:0055085 transmembrane transport 1 1014 2.01e-01
GO:BP GO:0048754 branching morphogenesis of an epithelial tube 1 121 2.06e-01
GO:BP GO:0055007 cardiac muscle cell differentiation 1 108 2.06e-01
GO:BP GO:0072359 circulatory system development 3 888 2.07e-01
GO:BP GO:0042770 signal transduction in response to DNA damage 1 180 2.08e-01
GO:BP GO:0002062 chondrocyte differentiation 1 89 2.08e-01
GO:BP GO:0072089 stem cell proliferation 1 84 2.11e-01
GO:BP GO:0007605 sensory perception of sound 1 97 2.11e-01
GO:BP GO:0010634 positive regulation of epithelial cell migration 1 132 2.11e-01
GO:BP GO:0007267 cell-cell signaling 1 1150 2.11e-01
GO:BP GO:0002065 columnar/cuboidal epithelial cell differentiation 1 80 2.11e-01
GO:BP GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 1 123 2.11e-01
GO:BP GO:0045893 positive regulation of DNA-templated transcription 1 1298 2.11e-01
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 1 1305 2.11e-01
GO:BP GO:0022008 neurogenesis 1 1297 2.11e-01
GO:BP GO:0001568 blood vessel development 2 537 2.12e-01
GO:BP GO:0035113 embryonic appendage morphogenesis 1 89 2.13e-01
GO:BP GO:2001257 regulation of cation channel activity 1 100 2.13e-01
GO:BP GO:0030326 embryonic limb morphogenesis 1 89 2.13e-01
GO:BP GO:1902850 microtubule cytoskeleton organization involved in mitosis 1 157 2.14e-01
GO:BP GO:0051049 regulation of transport 1 1268 2.15e-01
GO:BP GO:0009101 glycoprotein biosynthetic process 1 251 2.17e-01
GO:BP GO:0034502 protein localization to chromosome 1 101 2.19e-01
GO:BP GO:1901566 organonitrogen compound biosynthetic process 1 1496 2.20e-01
GO:BP GO:0048285 organelle fission 2 387 2.20e-01
GO:BP GO:0015031 protein transport 1 1366 2.20e-01
GO:BP GO:0001944 vasculature development 2 562 2.21e-01
GO:BP GO:0044281 small molecule metabolic process 1 1386 2.22e-01
GO:BP GO:0051254 positive regulation of RNA metabolic process 1 1425 2.22e-01
GO:BP GO:0007507 heart development 2 512 2.24e-01
GO:BP GO:0043405 regulation of MAP kinase activity 1 141 2.24e-01
GO:BP GO:0048565 digestive tract development 1 92 2.26e-01
GO:BP GO:0050954 sensory perception of mechanical stimulus 1 111 2.26e-01
GO:BP GO:0046578 regulation of Ras protein signal transduction 1 156 2.26e-01
GO:BP GO:0045184 establishment of protein localization 1 1468 2.27e-01
GO:BP GO:0031345 negative regulation of cell projection organization 1 154 2.27e-01
GO:BP GO:0030324 lung development 1 144 2.27e-01
GO:BP GO:0007127 meiosis I 1 73 2.27e-01
GO:BP GO:0061138 morphogenesis of a branching epithelium 1 143 2.27e-01
GO:BP GO:0043412 macromolecule modification 5 2948 2.29e-01
GO:BP GO:0051338 regulation of transferase activity 2 664 2.29e-01
GO:BP GO:0030323 respiratory tube development 1 148 2.29e-01
GO:BP GO:0048598 embryonic morphogenesis 2 438 2.31e-01
GO:BP GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction 1 144 2.32e-01
GO:BP GO:0061982 meiosis I cell cycle process 1 77 2.34e-01
GO:BP GO:0042552 myelination 1 114 2.35e-01
GO:BP GO:0055123 digestive system development 1 100 2.36e-01
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 1 1589 2.36e-01
GO:BP GO:0007272 ensheathment of neurons 1 116 2.36e-01
GO:BP GO:0060429 epithelium development 3 849 2.36e-01
GO:BP GO:0008366 axon ensheathment 1 116 2.36e-01
GO:BP GO:0048839 inner ear development 1 129 2.36e-01
GO:BP GO:0006109 regulation of carbohydrate metabolic process 1 147 2.36e-01
GO:BP GO:0035051 cardiocyte differentiation 1 134 2.36e-01
GO:BP GO:0001763 morphogenesis of a branching structure 1 155 2.37e-01
GO:BP GO:0035108 limb morphogenesis 1 113 2.37e-01
GO:BP GO:0035107 appendage morphogenesis 1 113 2.37e-01
GO:BP GO:0072073 kidney epithelium development 1 113 2.40e-01
GO:BP GO:0032879 regulation of localization 1 1570 2.41e-01
GO:BP GO:0016310 phosphorylation 3 1338 2.41e-01
GO:BP GO:0070374 positive regulation of ERK1 and ERK2 cascade 1 120 2.42e-01
GO:BP GO:0060541 respiratory system development 1 161 2.42e-01
GO:BP GO:0035264 multicellular organism growth 1 124 2.42e-01
GO:BP GO:0065009 regulation of molecular function 2 1905 2.43e-01
GO:BP GO:0008033 tRNA processing 1 131 2.43e-01
GO:BP GO:1903169 regulation of calcium ion transmembrane transport 1 120 2.43e-01
GO:BP GO:0009100 glycoprotein metabolic process 1 315 2.44e-01
GO:BP GO:0048589 developmental growth 2 522 2.44e-01
GO:BP GO:0042127 regulation of cell population proliferation 1 1568 2.44e-01
GO:BP GO:0071345 cellular response to cytokine stimulus 2 544 2.45e-01
GO:BP GO:0003008 system process 1 1194 2.51e-01
GO:BP GO:0050679 positive regulation of epithelial cell proliferation 1 152 2.52e-01
GO:BP GO:0071705 nitrogen compound transport 1 1689 2.53e-01
GO:BP GO:0009888 tissue development 4 1425 2.54e-01
GO:BP GO:0043583 ear development 1 150 2.55e-01
GO:BP GO:0061351 neural precursor cell proliferation 1 122 2.55e-01
GO:BP GO:0048592 eye morphogenesis 1 114 2.55e-01
GO:BP GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 1 71 2.56e-01
GO:BP GO:0010810 regulation of cell-substrate adhesion 1 171 2.58e-01
GO:BP GO:0051783 regulation of nuclear division 1 115 2.60e-01
GO:BP GO:0051649 establishment of localization in cell 1 1842 2.60e-01
GO:BP GO:0035239 tube morphogenesis 2 663 2.60e-01
GO:BP GO:0048522 positive regulation of cellular process 2 4197 2.60e-01
GO:BP GO:0006357 regulation of transcription by RNA polymerase II 1 1764 2.61e-01
GO:BP GO:0007167 enzyme-linked receptor protein signaling pathway 2 741 2.64e-01
GO:BP GO:0050793 regulation of developmental process 1 1813 2.66e-01
GO:BP GO:0060560 developmental growth involved in morphogenesis 1 207 2.68e-01
GO:BP GO:0010632 regulation of epithelial cell migration 1 195 2.68e-01
GO:BP GO:0071356 cellular response to tumor necrosis factor 1 159 2.69e-01
GO:BP GO:0007399 nervous system development 1 1886 2.69e-01
GO:BP GO:0006366 transcription by RNA polymerase II 1 1852 2.70e-01
GO:BP GO:0048736 appendage development 1 141 2.72e-01
GO:BP GO:0060173 limb development 1 141 2.72e-01
GO:BP GO:0010557 positive regulation of macromolecule biosynthetic process 1 1896 2.76e-01
GO:BP GO:0034097 response to cytokine 2 609 2.77e-01
GO:BP GO:0009755 hormone-mediated signaling pathway 1 142 2.82e-01
GO:BP GO:0030334 regulation of cell migration 2 707 2.82e-01
GO:BP GO:0031328 positive regulation of cellular biosynthetic process 1 1958 2.83e-01
GO:BP GO:0009605 response to external stimulus 1 1635 2.83e-01
GO:BP GO:0009891 positive regulation of biosynthetic process 1 1972 2.85e-01
GO:BP GO:0034612 response to tumor necrosis factor 1 176 2.85e-01
GO:BP GO:0008104 protein localization 1 2128 2.86e-01
GO:BP GO:0070727 cellular macromolecule localization 1 2137 2.87e-01
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 1 1669 2.87e-01
GO:BP GO:0048468 cell development 1 1950 2.88e-01
GO:BP GO:0009966 regulation of signal transduction 4 2271 2.90e-01
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 1 1708 2.91e-01
GO:BP GO:0045765 regulation of angiogenesis 1 200 2.91e-01
GO:BP GO:0051216 cartilage development 1 149 2.91e-01
GO:BP GO:0009890 negative regulation of biosynthetic process 1 1721 2.91e-01
GO:BP GO:1901342 regulation of vasculature development 1 202 2.92e-01
GO:BP GO:0003007 heart morphogenesis 1 217 2.92e-01
GO:BP GO:0045165 cell fate commitment 1 157 2.94e-01
GO:BP GO:0002064 epithelial cell development 1 156 2.95e-01
GO:BP GO:0048518 positive regulation of biological process 2 4566 2.95e-01
GO:BP GO:1903039 positive regulation of leukocyte cell-cell adhesion 1 157 2.95e-01
GO:BP GO:0018193 peptidyl-amino acid modification 2 866 2.98e-01
GO:BP GO:0065008 regulation of biological quality 1 2085 2.98e-01
GO:BP GO:2000145 regulation of cell motility 2 741 2.98e-01
GO:BP GO:0051056 regulation of small GTPase mediated signal transduction 1 249 3.00e-01
GO:BP GO:0051924 regulation of calcium ion transport 1 167 3.02e-01
GO:BP GO:0023052 signaling 2 4134 3.05e-01
GO:BP GO:0018105 peptidyl-serine phosphorylation 1 242 3.06e-01
GO:BP GO:0032502 developmental process 2 4445 3.06e-01
GO:BP GO:0071702 organic substance transport 1 2133 3.06e-01
GO:BP GO:0048738 cardiac muscle tissue development 1 202 3.06e-01
GO:BP GO:0006399 tRNA metabolic process 1 189 3.06e-01
GO:BP GO:0051346 negative regulation of hydrolase activity 1 206 3.07e-01
GO:BP GO:0032412 regulation of monoatomic ion transmembrane transporter activity 1 189 3.07e-01
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 1 2367 3.07e-01
GO:BP GO:0007154 cell communication 2 4210 3.10e-01
GO:BP GO:0040012 regulation of locomotion 2 762 3.10e-01
GO:BP GO:0018209 peptidyl-serine modification 1 254 3.17e-01
GO:BP GO:0022898 regulation of transmembrane transporter activity 1 200 3.17e-01
GO:BP GO:0022402 cell cycle process 3 1078 3.17e-01
GO:BP GO:0014706 striated muscle tissue development 1 214 3.17e-01
GO:BP GO:0031324 negative regulation of cellular metabolic process 1 2069 3.17e-01
GO:BP GO:0019538 protein metabolic process 6 4202 3.17e-01
GO:BP GO:1901135 carbohydrate derivative metabolic process 2 841 3.17e-01
GO:BP GO:0008283 cell population proliferation 1 2340 3.17e-01
GO:BP GO:0033036 macromolecule localization 1 2448 3.17e-01
GO:BP GO:0010631 epithelial cell migration 1 253 3.17e-01
GO:BP GO:2000241 regulation of reproductive process 1 126 3.19e-01
GO:BP GO:0090132 epithelium migration 1 253 3.19e-01
GO:BP GO:0007265 Ras protein signal transduction 1 287 3.20e-01
GO:BP GO:0060562 epithelial tube morphogenesis 1 276 3.20e-01
GO:BP GO:0090130 tissue migration 1 257 3.23e-01
GO:BP GO:0022409 positive regulation of cell-cell adhesion 1 188 3.23e-01
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 1 2131 3.24e-01
GO:BP GO:0032409 regulation of transporter activity 1 212 3.26e-01
GO:BP GO:0030198 extracellular matrix organization 1 233 3.27e-01
GO:BP GO:0043062 extracellular structure organization 1 234 3.27e-01
GO:BP GO:0071900 regulation of protein serine/threonine kinase activity 1 274 3.27e-01
GO:BP GO:0045229 external encapsulating structure organization 1 234 3.27e-01
GO:BP GO:0031325 positive regulation of cellular metabolic process 1 2518 3.27e-01
GO:BP GO:0006355 regulation of DNA-templated transcription 1 2560 3.30e-01
GO:BP GO:2001141 regulation of RNA biosynthetic process 1 2577 3.31e-01
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 1 2607 3.33e-01
GO:BP GO:0043087 regulation of GTPase activity 1 288 3.33e-01
GO:BP GO:0009892 negative regulation of metabolic process 1 2297 3.39e-01
GO:BP GO:0006351 DNA-templated transcription 1 2669 3.39e-01
GO:BP GO:0032774 RNA biosynthetic process 1 2699 3.42e-01
GO:BP GO:0031589 cell-substrate adhesion 1 271 3.45e-01
GO:BP GO:0021537 telencephalon development 1 208 3.45e-01
GO:BP GO:0051641 cellular localization 1 2822 3.45e-01
GO:BP GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 1 113 3.47e-01
GO:BP GO:0061448 connective tissue development 1 212 3.49e-01
GO:BP GO:0009968 negative regulation of signal transduction 2 1017 3.50e-01
GO:BP GO:0040007 growth 2 737 3.50e-01
GO:BP GO:0051146 striated muscle cell differentiation 1 239 3.50e-01
GO:BP GO:1904062 regulation of monoatomic cation transmembrane transport 1 232 3.51e-01
GO:BP GO:0051252 regulation of RNA metabolic process 1 2824 3.51e-01
GO:BP GO:0050678 regulation of epithelial cell proliferation 1 268 3.53e-01
GO:BP GO:1903037 regulation of leukocyte cell-cell adhesion 1 210 3.53e-01
GO:BP GO:0050878 regulation of body fluid levels 1 237 3.53e-01
GO:BP GO:0019222 regulation of metabolic process 2 4998 3.64e-01
GO:BP GO:0048731 system development 1 2886 3.67e-01
GO:BP GO:0070588 calcium ion transmembrane transport 1 221 3.68e-01
GO:BP GO:0040011 locomotion 2 854 3.72e-01
GO:BP GO:0043933 protein-containing complex organization 1 1964 3.72e-01
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 1 3054 3.72e-01
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 1 3059 3.72e-01
GO:BP GO:0018130 heterocycle biosynthetic process 1 3115 3.77e-01
GO:BP GO:0019438 aromatic compound biosynthetic process 1 3116 3.77e-01
GO:BP GO:0007159 leukocyte cell-cell adhesion 1 233 3.77e-01
GO:BP GO:1901564 organonitrogen compound metabolic process 7 4919 3.79e-01
GO:BP GO:0010648 negative regulation of cell communication 2 1088 3.83e-01
GO:BP GO:0023057 negative regulation of signaling 2 1090 3.83e-01
GO:BP GO:0098813 nuclear chromosome segregation 1 264 3.86e-01
GO:BP GO:1901362 organic cyclic compound biosynthetic process 1 3221 3.87e-01
GO:BP GO:0030522 intracellular receptor signaling pathway 1 256 3.91e-01
GO:BP GO:0032501 multicellular organismal process 2 4807 3.91e-01
GO:BP GO:0051656 establishment of organelle localization 1 397 3.93e-01
GO:BP GO:0001667 ameboidal-type cell migration 1 358 3.93e-01
GO:BP GO:0019932 second-messenger-mediated signaling 1 182 3.94e-01
GO:BP GO:0010959 regulation of metal ion transport 1 271 3.95e-01
GO:BP GO:0022414 reproductive process 3 924 3.99e-01
GO:BP GO:0048583 regulation of response to stimulus 2 2877 3.99e-01
GO:BP GO:0050673 epithelial cell proliferation 1 318 3.99e-01
GO:BP GO:0000003 reproduction 3 933 4.02e-01
GO:BP GO:0007275 multicellular organism development 1 3355 4.13e-01
GO:BP GO:0006874 intracellular calcium ion homeostasis 1 208 4.13e-01
GO:BP GO:0051051 negative regulation of transport 1 317 4.16e-01
GO:BP GO:0022407 regulation of cell-cell adhesion 1 292 4.19e-01
GO:BP GO:0045785 positive regulation of cell adhesion 1 319 4.19e-01
GO:BP GO:0006810 transport 1 3294 4.19e-01
GO:BP GO:0002009 morphogenesis of an epithelium 1 415 4.24e-01
GO:BP GO:0001525 angiogenesis 1 389 4.24e-01
GO:BP GO:0009790 embryo development 2 859 4.24e-01
GO:BP GO:0042692 muscle cell differentiation 1 329 4.24e-01
GO:BP GO:0006816 calcium ion transport 1 275 4.24e-01
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 1 3743 4.28e-01
GO:BP GO:0055074 calcium ion homeostasis 1 221 4.31e-01
GO:BP GO:0051234 establishment of localization 1 3453 4.31e-01
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 6 4243 4.35e-01
GO:BP GO:0034765 regulation of monoatomic ion transmembrane transport 1 296 4.35e-01
GO:BP GO:0060537 muscle tissue development 1 347 4.41e-01
GO:BP GO:0030900 forebrain development 1 290 4.42e-01
GO:BP GO:0006796 phosphate-containing compound metabolic process 3 2096 4.46e-01
GO:BP GO:0016477 cell migration 2 1065 4.50e-01
GO:BP GO:0006793 phosphorus metabolic process 3 2118 4.52e-01
GO:BP GO:0071310 cellular response to organic substance 3 1390 4.53e-01
GO:BP GO:0048585 negative regulation of response to stimulus 2 1267 4.58e-01
GO:BP GO:0048878 chemical homeostasis 2 689 4.58e-01
GO:BP GO:0007059 chromosome segregation 1 360 4.58e-01
GO:BP GO:0051640 organelle localization 1 521 4.61e-01
GO:BP GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 1 470 4.67e-01
GO:BP GO:0080090 regulation of primary metabolic process 6 4371 4.69e-01
GO:BP GO:0010468 regulation of gene expression 1 3587 4.73e-01
GO:BP GO:0048523 negative regulation of cellular process 1 3773 4.73e-01
GO:BP GO:0048729 tissue morphogenesis 1 501 4.75e-01
GO:BP GO:0051179 localization 1 3983 4.75e-01
GO:BP GO:0010556 regulation of macromolecule biosynthetic process 1 3702 4.81e-01
GO:BP GO:0031344 regulation of cell projection organization 1 542 4.85e-01
GO:BP GO:0000226 microtubule cytoskeleton organization 1 549 4.85e-01
GO:BP GO:0019953 sexual reproduction 2 633 4.85e-01
GO:BP GO:0001934 positive regulation of protein phosphorylation 1 465 4.89e-01
GO:BP GO:0031326 regulation of cellular biosynthetic process 1 3794 4.89e-01
GO:BP GO:0034470 ncRNA processing 1 397 4.89e-01
GO:BP GO:0009889 regulation of biosynthetic process 1 3820 4.90e-01
GO:BP GO:0048856 anatomical structure development 1 4100 4.95e-01
GO:BP GO:0050790 regulation of catalytic activity 1 1349 4.95e-01
GO:BP GO:0043269 regulation of monoatomic ion transport 1 369 4.97e-01
GO:BP GO:0050896 response to stimulus 2 5721 4.97e-01
GO:BP GO:0048519 negative regulation of biological process 1 4026 4.97e-01
GO:BP GO:0051129 negative regulation of cellular component organization 1 592 5.08e-01
GO:BP GO:0048870 cell motility 2 1169 5.08e-01
GO:BP GO:0048513 animal organ development 4 2156 5.11e-01
GO:BP GO:0042327 positive regulation of phosphorylation 1 511 5.16e-01
GO:BP GO:0006974 DNA damage response 1 795 5.18e-01
GO:BP GO:1903047 mitotic cell cycle process 1 689 5.30e-01
GO:BP GO:0045937 positive regulation of phosphate metabolic process 1 559 5.50e-01
GO:BP GO:0010562 positive regulation of phosphorus metabolic process 1 559 5.50e-01
GO:BP GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1 288 5.55e-01
GO:BP GO:0000398 mRNA splicing, via spliceosome 1 288 5.55e-01
GO:BP GO:0000375 RNA splicing, via transesterification reactions 1 292 5.55e-01
GO:BP GO:0032870 cellular response to hormone stimulus 1 449 5.55e-01
GO:BP GO:0031323 regulation of cellular metabolic process 1 4563 5.55e-01
GO:BP GO:0060255 regulation of macromolecule metabolic process 1 4593 5.58e-01
GO:BP GO:0030003 intracellular monoatomic cation homeostasis 1 364 5.62e-01
GO:BP GO:0030155 regulation of cell adhesion 1 535 5.64e-01
GO:BP GO:0098771 inorganic ion homeostasis 1 355 5.66e-01
GO:BP GO:0006873 intracellular monoatomic ion homeostasis 1 369 5.67e-01
GO:BP GO:0016070 RNA metabolic process 1 3573 5.68e-01
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 1 680 5.73e-01
GO:BP GO:0043066 negative regulation of apoptotic process 1 662 5.79e-01
GO:BP GO:0008380 RNA splicing 1 426 5.79e-01
GO:BP GO:0031401 positive regulation of protein modification process 1 664 5.81e-01
GO:BP GO:0000278 mitotic cell cycle 1 815 5.86e-01
GO:BP GO:0061061 muscle structure development 1 552 5.86e-01
GO:BP GO:0043069 negative regulation of programmed cell death 1 685 5.86e-01
GO:BP GO:0006397 mRNA processing 1 451 5.86e-01
GO:BP GO:0051276 chromosome organization 1 533 5.87e-01
GO:BP GO:0007600 sensory perception 1 259 6.00e-01
GO:BP GO:0034660 ncRNA metabolic process 1 561 6.00e-01
GO:BP GO:0051301 cell division 1 569 6.00e-01
GO:BP GO:0007017 microtubule-based process 1 757 6.00e-01
GO:BP GO:0051336 regulation of hydrolase activity 1 680 6.00e-01
GO:BP GO:0090304 nucleic acid metabolic process 1 4018 6.00e-01
GO:BP GO:0055080 monoatomic cation homeostasis 1 410 6.01e-01
GO:BP GO:0050801 monoatomic ion homeostasis 1 416 6.06e-01
GO:BP GO:0048609 multicellular organismal reproductive process 1 538 6.11e-01
GO:BP GO:0007420 brain development 1 546 6.19e-01
GO:BP GO:0098662 inorganic cation transmembrane transport 1 537 6.19e-01
GO:BP GO:0098609 cell-cell adhesion 1 599 6.24e-01
GO:BP GO:0016071 mRNA metabolic process 1 671 6.26e-01
GO:BP GO:0098655 monoatomic cation transmembrane transport 1 554 6.28e-01
GO:BP GO:0032504 multicellular organism reproduction 1 558 6.28e-01
GO:BP GO:0044087 regulation of cellular component biogenesis 1 802 6.30e-01
GO:BP GO:0007165 signal transduction 2 3803 6.30e-01
GO:BP GO:0006139 nucleobase-containing compound metabolic process 1 4423 6.31e-01
GO:BP GO:0030001 metal ion transport 1 568 6.34e-01
GO:BP GO:0009653 anatomical structure morphogenesis 3 1952 6.34e-01
GO:BP GO:0060322 head development 1 588 6.35e-01
GO:BP GO:0070887 cellular response to chemical stimulus 3 1857 6.35e-01
GO:BP GO:0016043 cellular component organization 1 5106 6.35e-01
GO:BP GO:0046483 heterocycle metabolic process 1 4537 6.40e-01
GO:BP GO:0006725 cellular aromatic compound metabolic process 1 4561 6.43e-01
GO:BP GO:0098660 inorganic ion transmembrane transport 1 582 6.48e-01
GO:BP GO:0071840 cellular component organization or biogenesis 1 5307 6.49e-01
GO:BP GO:0010033 response to organic substance 3 1942 6.54e-01
GO:BP GO:0055082 intracellular chemical homeostasis 1 498 6.55e-01
GO:BP GO:1901360 organic cyclic compound metabolic process 1 4713 6.57e-01
GO:BP GO:0009725 response to hormone 1 624 6.59e-01
GO:BP GO:0010564 regulation of cell cycle process 1 622 6.59e-01
GO:BP GO:0048646 anatomical structure formation involved in morphogenesis 1 868 6.62e-01
GO:BP GO:0010628 positive regulation of gene expression 1 795 6.65e-01
GO:BP GO:0034641 cellular nitrogen compound metabolic process 1 4913 6.66e-01
GO:BP GO:0051128 regulation of cellular component organization 3 1981 6.77e-01
GO:BP GO:0034220 monoatomic ion transmembrane transport 1 650 6.81e-01
GO:BP GO:0006812 monoatomic cation transport 1 677 6.86e-01
GO:BP GO:0019725 cellular homeostasis 1 583 7.01e-01
GO:BP GO:0010467 gene expression 1 4733 7.05e-01
GO:BP GO:0008284 positive regulation of cell population proliferation 1 886 7.14e-01
GO:BP GO:0051247 positive regulation of protein metabolic process 1 1067 7.19e-01
GO:BP GO:0007166 cell surface receptor signaling pathway 2 1889 7.19e-01
GO:BP GO:0007417 central nervous system development 1 750 7.22e-01
GO:BP GO:0009059 macromolecule biosynthetic process 1 5148 7.39e-01
GO:BP GO:0007010 cytoskeleton organization 1 1186 7.39e-01
GO:BP GO:0050877 nervous system process 1 628 7.47e-01
GO:BP GO:0006811 monoatomic ion transport 1 788 7.50e-01
GO:BP GO:0030030 cell projection organization 1 1236 7.67e-01
GO:BP GO:0050794 regulation of cellular process 2 7632 7.71e-01
GO:BP GO:0051716 cellular response to stimulus 2 4929 7.73e-01
GO:BP GO:0007155 cell adhesion 1 996 7.76e-01
GO:BP GO:0006396 RNA processing 1 928 7.79e-01
GO:BP GO:0045944 positive regulation of transcription by RNA polymerase II 1 918 7.83e-01
GO:BP GO:0033365 protein localization to organelle 1 860 7.85e-01
GO:BP GO:0044249 cellular biosynthetic process 1 5813 7.93e-01
GO:BP GO:1901576 organic substance biosynthetic process 1 5875 7.99e-01
GO:BP GO:0009058 biosynthetic process 1 5912 8.02e-01
GO:BP GO:0033043 regulation of organelle organization 1 1001 8.14e-01
GO:BP GO:0050789 regulation of biological process 2 8017 8.37e-01
GO:BP GO:0007186 G protein-coupled receptor signaling pathway 1 386 8.37e-01
GO:BP GO:0042221 response to chemical 3 2456 8.73e-01
GO:BP GO:0065007 biological regulation 2 8282 8.93e-01
GO:BP GO:0006996 organelle organization 3 2974 8.99e-01
GO:BP GO:0006807 nitrogen compound metabolic process 1 7431 9.01e-01
GO:BP GO:0043170 macromolecule metabolic process 1 7084 9.16e-01
GO:BP GO:0044238 primary metabolic process 1 7788 9.40e-01
GO:BP GO:0044237 cellular metabolic process 1 7562 9.57e-01
GO:BP GO:0022607 cellular component assembly 2 2459 9.95e-01
GO:BP GO:0044085 cellular component biogenesis 2 2722 9.97e-01
GO:BP GO:0009987 cellular process 1 11410 1.00e+00
GO:BP GO:0008152 metabolic process 1 8522 1.00e+00
GO:BP GO:0008150 biological_process 1 12027 1.00e+00
GO:BP GO:0071704 organic substance metabolic process 1 8176 1.00e+00
KEGG KEGG:05202 Transcriptional misregulation in cancer 3 128 3.30e-04
KEGG KEGG:04115 p53 signaling pathway 2 65 5.02e-04
KEGG KEGG:05223 Non-small cell lung cancer 3 67 5.02e-04
KEGG KEGG:05212 Pancreatic cancer 2 75 5.02e-04
KEGG KEGG:05222 Small cell lung cancer 3 87 5.02e-04
KEGG KEGG:05213 Endometrial cancer 2 57 5.02e-04
KEGG KEGG:05214 Glioma 2 67 5.02e-04
KEGG KEGG:05216 Thyroid cancer 2 35 5.02e-04
KEGG KEGG:05220 Chronic myeloid leukemia 2 75 5.02e-04
KEGG KEGG:05217 Basal cell carcinoma 2 49 5.02e-04
KEGG KEGG:05218 Melanoma 2 58 5.02e-04
KEGG KEGG:05210 Colorectal cancer 2 84 5.89e-04
KEGG KEGG:04064 NF-kappa B signaling pathway 2 71 7.65e-04
KEGG KEGG:05226 Gastric cancer 3 117 1.09e-03
KEGG KEGG:04210 Apoptosis 2 118 1.09e-03
KEGG KEGG:04068 FoxO signaling pathway 2 109 1.09e-03
KEGG KEGG:05224 Breast cancer 2 117 1.21e-03
KEGG KEGG:04218 Cellular senescence 2 145 1.24e-03
KEGG KEGG:04110 Cell cycle 2 151 1.24e-03
KEGG KEGG:05225 Hepatocellular carcinoma 2 145 1.31e-03
KEGG KEGG:05169 Epstein-Barr virus infection 2 153 1.78e-03
KEGG KEGG:04710 Circadian rhythm 1 30 3.41e-03
KEGG KEGG:04010 MAPK signaling pathway 2 240 3.55e-03
KEGG KEGG:05221 Acute myeloid leukemia 1 56 6.16e-03
KEGG KEGG:04713 Circadian entrainment 1 69 8.57e-03
KEGG KEGG:05200 Pathways in cancer 2 409 9.94e-03
KEGG KEGG:04114 Oocyte meiosis 1 108 1.57e-01
KEGG KEGG:05206 MicroRNAs in cancer 1 149 2.40e-01
KEGG KEGG:05168 Herpes simplex virus 1 infection 1 415 2.41e-01
KEGG KEGG:00000 KEGG root term 2 5548 3.61e-01
TRZnomtable3h %>%
  filter(source=="KEGG") %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "Enrichment of KEGG terms using nominal pvalue TRZ 3hour genes in my data") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")
Enrichment of KEGG terms using nominal pvalue TRZ 3hour genes in my data
source term_id term_name intersection_size term_size p_value
KEGG KEGG:05202 Transcriptional misregulation in cancer 3 128 3.30e-04
KEGG KEGG:04115 p53 signaling pathway 2 65 5.02e-04
KEGG KEGG:05223 Non-small cell lung cancer 3 67 5.02e-04
KEGG KEGG:05212 Pancreatic cancer 2 75 5.02e-04
KEGG KEGG:05222 Small cell lung cancer 3 87 5.02e-04
KEGG KEGG:05213 Endometrial cancer 2 57 5.02e-04
KEGG KEGG:05214 Glioma 2 67 5.02e-04
KEGG KEGG:05216 Thyroid cancer 2 35 5.02e-04
KEGG KEGG:05220 Chronic myeloid leukemia 2 75 5.02e-04
KEGG KEGG:05217 Basal cell carcinoma 2 49 5.02e-04
KEGG KEGG:05218 Melanoma 2 58 5.02e-04
KEGG KEGG:05210 Colorectal cancer 2 84 5.89e-04
KEGG KEGG:04064 NF-kappa B signaling pathway 2 71 7.65e-04
KEGG KEGG:05226 Gastric cancer 3 117 1.09e-03
KEGG KEGG:04210 Apoptosis 2 118 1.09e-03
KEGG KEGG:04068 FoxO signaling pathway 2 109 1.09e-03
KEGG KEGG:05224 Breast cancer 2 117 1.21e-03
KEGG KEGG:04218 Cellular senescence 2 145 1.24e-03
KEGG KEGG:04110 Cell cycle 2 151 1.24e-03
KEGG KEGG:05225 Hepatocellular carcinoma 2 145 1.31e-03
KEGG KEGG:05169 Epstein-Barr virus infection 2 153 1.78e-03
KEGG KEGG:04710 Circadian rhythm 1 30 3.41e-03
KEGG KEGG:04010 MAPK signaling pathway 2 240 3.55e-03
KEGG KEGG:05221 Acute myeloid leukemia 1 56 6.16e-03
KEGG KEGG:04713 Circadian entrainment 1 69 8.57e-03
KEGG KEGG:05200 Pathways in cancer 2 409 9.94e-03
KEGG KEGG:04114 Oocyte meiosis 1 108 1.57e-01
KEGG KEGG:05206 MicroRNAs in cancer 1 149 2.40e-01
KEGG KEGG:05168 Herpes simplex virus 1 infection 1 415 2.41e-01
KEGG KEGG:00000 KEGG root term 2 5548 3.61e-01

TRZ 24 hour nom de

# TRZresgenes24h <- gost(query = TRZ_list24h$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = TRUE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = backGL$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(TRZresgenes24h,"data/DEG-GO/TRZresgenes24h.RDS")
TRZresgenes24h <- readRDS("data/DEG-GO/TRZresgenes24h.RDS")

TRZnom24h <- gostplot(TRZresgenes24h, capped = FALSE, interactive = TRUE)
TRZnom24h
TRZnomtable24h <- TRZresgenes24h$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

TRZnomtable24h %>%
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")
source term_id term_name intersection_size term_size p_value
GO:BP GO:0098728 germline stem cell asymmetric division 1 2 6.00e-02
GO:BP GO:0048133 male germ-line stem cell asymmetric division 1 2 6.00e-02
GO:BP GO:0042078 germ-line stem cell division 1 2 6.00e-02
GO:BP GO:0098722 asymmetric stem cell division 1 2 6.00e-02
GO:BP GO:0015757 galactose transmembrane transport 1 4 9.34e-02
GO:BP GO:0098708 glucose import across plasma membrane 1 5 9.34e-02
GO:BP GO:0098704 carbohydrate import across plasma membrane 1 5 9.34e-02
GO:BP GO:0062197 cellular response to chemical stress 3 269 9.34e-02
GO:BP GO:0061643 chemorepulsion of axon 1 6 9.34e-02
GO:BP GO:0060252 positive regulation of glial cell proliferation 1 14 9.34e-02
GO:BP GO:0060251 regulation of glial cell proliferation 1 26 9.34e-02
GO:BP GO:0051939 gamma-aminobutyric acid import 1 3 9.34e-02
GO:BP GO:0051764 actin crosslink formation 1 9 9.34e-02
GO:BP GO:0006979 response to oxidative stress 3 328 9.34e-02
GO:BP GO:0048232 male gamete generation 2 346 9.34e-02
GO:BP GO:0014009 glial cell proliferation 1 40 9.34e-02
GO:BP GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 1 7 9.34e-02
GO:BP GO:0042918 alkanesulfonate transport 1 6 9.34e-02
GO:BP GO:0008356 asymmetric cell division 1 14 9.34e-02
GO:BP GO:0014015 positive regulation of gliogenesis 1 44 9.34e-02
GO:BP GO:0007283 spermatogenesis 2 333 9.34e-02
GO:BP GO:0007288 sperm axoneme assembly 1 20 9.34e-02
GO:BP GO:0036159 inner dynein arm assembly 1 8 9.34e-02
GO:BP GO:0034599 cellular response to oxidative stress 3 218 9.34e-02
GO:BP GO:0022412 cellular process involved in reproduction in multicellular organism 2 255 9.34e-02
GO:BP GO:0018345 protein palmitoylation 1 30 9.34e-02
GO:BP GO:0018231 peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine 1 21 9.34e-02
GO:BP GO:0018230 peptidyl-L-cysteine S-palmitoylation 1 21 9.34e-02
GO:BP GO:0017145 stem cell division 1 25 9.34e-02
GO:BP GO:0015734 taurine transport 1 6 9.34e-02
GO:BP GO:0007281 germ cell development 2 194 9.34e-02
GO:BP GO:0010232 vascular transport 2 72 9.34e-02
GO:BP GO:1902965 regulation of protein localization to early endosome 1 10 9.34e-02
GO:BP GO:1902966 positive regulation of protein localization to early endosome 1 10 9.34e-02
GO:BP GO:1904059 regulation of locomotor rhythm 1 3 9.34e-02
GO:BP GO:1904350 regulation of protein catabolic process in the vacuole 1 13 9.34e-02
GO:BP GO:1904351 negative regulation of protein catabolic process in the vacuole 1 5 9.34e-02
GO:BP GO:1905165 regulation of lysosomal protein catabolic process 1 11 9.34e-02
GO:BP GO:1905166 negative regulation of lysosomal protein catabolic process 1 5 9.34e-02
GO:BP GO:1905668 positive regulation of protein localization to endosome 1 14 9.34e-02
GO:BP GO:0150104 transport across blood-brain barrier 2 72 9.34e-02
GO:BP GO:1902946 protein localization to early endosome 1 12 9.34e-02
GO:BP GO:1990708 conditioned place preference 1 2 9.34e-02
GO:BP GO:0140271 hexose import across plasma membrane 1 5 9.34e-02
GO:BP GO:1905666 regulation of protein localization to endosome 1 15 9.57e-02
GO:BP GO:0018198 peptidyl-cysteine modification 1 41 9.78e-02
GO:BP GO:0045666 positive regulation of neuron differentiation 1 63 9.78e-02
GO:BP GO:0014013 regulation of gliogenesis 1 66 1.02e-01
GO:BP GO:0006044 N-acetylglucosamine metabolic process 1 16 1.05e-01
GO:BP GO:0070286 axonemal dynein complex assembly 1 21 1.10e-01
GO:BP GO:0015812 gamma-aminobutyric acid transport 1 11 1.10e-01
GO:BP GO:0120316 sperm flagellum assembly 1 27 1.10e-01
GO:BP GO:1905146 lysosomal protein catabolic process 1 19 1.10e-01
GO:BP GO:0070837 dehydroascorbic acid transport 1 7 1.10e-01
GO:BP GO:0032328 alanine transport 1 13 1.10e-01
GO:BP GO:0003351 epithelial cilium movement involved in extracellular fluid movement 1 30 1.10e-01
GO:BP GO:1901334 lactone metabolic process 1 10 1.11e-01
GO:BP GO:0006858 extracellular transport 1 33 1.11e-01
GO:BP GO:0010887 negative regulation of cholesterol storage 1 8 1.11e-01
GO:BP GO:0007039 protein catabolic process in the vacuole 1 22 1.11e-01
GO:BP GO:0007276 gamete generation 2 465 1.11e-01
GO:BP GO:0019852 L-ascorbic acid metabolic process 1 10 1.11e-01
GO:BP GO:1901071 glucosamine-containing compound metabolic process 1 19 1.14e-01
GO:BP GO:0036010 protein localization to endosome 1 28 1.25e-01
GO:BP GO:0048609 multicellular organismal reproductive process 2 538 1.27e-01
GO:BP GO:0106072 negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1 8 1.30e-01
GO:BP GO:0044458 motile cilium assembly 1 46 1.34e-01
GO:BP GO:0042158 lipoprotein biosynthetic process 1 92 1.34e-01
GO:BP GO:0045664 regulation of neuron differentiation 1 137 1.34e-01
GO:BP GO:0098739 import across plasma membrane 2 130 1.34e-01
GO:BP GO:0038003 G protein-coupled opioid receptor signaling pathway 1 5 1.34e-01
GO:BP GO:0006497 protein lipidation 1 89 1.34e-01
GO:BP GO:0032504 multicellular organism reproduction 2 558 1.34e-01
GO:BP GO:0003006 developmental process involved in reproduction 2 603 1.34e-01
GO:BP GO:0019953 sexual reproduction 2 633 1.43e-01
GO:BP GO:0035810 positive regulation of urine volume 1 10 1.43e-01
GO:BP GO:0106070 regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway 1 11 1.43e-01
GO:BP GO:0051382 kinetochore assembly 1 17 1.43e-01
GO:BP GO:0043951 negative regulation of cAMP-mediated signaling 1 10 1.43e-01
GO:BP GO:0050769 positive regulation of neurogenesis 1 190 1.43e-01
GO:BP GO:0006040 amino sugar metabolic process 1 34 1.46e-01
GO:BP GO:0016202 regulation of striated muscle tissue development 1 13 1.46e-01
GO:BP GO:0010885 regulation of cholesterol storage 1 13 1.47e-01
GO:BP GO:0044849 estrous cycle 1 14 1.51e-01
GO:BP GO:0045475 locomotor rhythm 1 13 1.51e-01
GO:BP GO:0042157 lipoprotein metabolic process 1 116 1.54e-01
GO:BP GO:0045662 negative regulation of myoblast differentiation 1 20 1.54e-01
GO:BP GO:0051962 positive regulation of nervous system development 1 222 1.54e-01
GO:BP GO:0035082 axoneme assembly 1 54 1.54e-01
GO:BP GO:0051383 kinetochore organization 1 21 1.54e-01
GO:BP GO:0000226 microtubule cytoskeleton organization 2 549 1.54e-01
GO:BP GO:0050435 amyloid-beta metabolic process 1 48 1.61e-01
GO:BP GO:0010888 negative regulation of lipid storage 1 15 1.63e-01
GO:BP GO:0048634 regulation of muscle organ development 1 14 1.63e-01
GO:BP GO:0089718 amino acid import across plasma membrane 1 38 1.67e-01
GO:BP GO:0010878 cholesterol storage 1 18 1.67e-01
GO:BP GO:0048843 negative regulation of axon extension involved in axon guidance 1 26 1.67e-01
GO:BP GO:0042063 gliogenesis 1 244 1.67e-01
GO:BP GO:0003018 vascular process in circulatory system 2 198 1.67e-01
GO:BP GO:1901386 negative regulation of voltage-gated calcium channel activity 1 14 1.67e-01
GO:BP GO:0072348 sulfur compound transport 1 36 1.71e-01
GO:BP GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 1 33 1.74e-01
GO:BP GO:0035809 regulation of urine volume 1 14 1.74e-01
GO:BP GO:0001578 microtubule bundle formation 1 79 1.74e-01
GO:BP GO:0050767 regulation of neurogenesis 1 302 1.75e-01
GO:BP GO:0030317 flagellated sperm motility 1 62 1.78e-01
GO:BP GO:0043543 protein acylation 1 193 1.78e-01
GO:BP GO:0034508 centromere complex assembly 1 29 1.78e-01
GO:BP GO:0015804 neutral amino acid transport 1 43 1.78e-01
GO:BP GO:0097722 sperm motility 1 62 1.78e-01
GO:BP GO:0048841 regulation of axon extension involved in axon guidance 1 31 1.78e-01
GO:BP GO:0006487 protein N-linked glycosylation 1 65 1.81e-01
GO:BP GO:0043620 regulation of DNA-templated transcription in response to stress 1 38 1.81e-01
GO:BP GO:1902284 neuron projection extension involved in neuron projection guidance 1 35 1.81e-01
GO:BP GO:0048846 axon extension involved in axon guidance 1 35 1.81e-01
GO:BP GO:0015800 acidic amino acid transport 1 39 1.81e-01
GO:BP GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 1 30 1.81e-01
GO:BP GO:0060294 cilium movement involved in cell motility 1 69 1.81e-01
GO:BP GO:0010720 positive regulation of cell development 1 318 1.81e-01
GO:BP GO:0021591 ventricular system development 1 29 1.82e-01
GO:BP GO:0051960 regulation of nervous system development 1 357 1.82e-01
GO:BP GO:0022414 reproductive process 2 924 1.82e-01
GO:BP GO:0060285 cilium-dependent cell motility 1 72 1.82e-01
GO:BP GO:0001539 cilium or flagellum-dependent cell motility 1 72 1.82e-01
GO:BP GO:0000003 reproduction 2 933 1.83e-01
GO:BP GO:0071526 semaphorin-plexin signaling pathway 1 44 2.02e-01
GO:BP GO:0090181 regulation of cholesterol metabolic process 1 27 2.02e-01
GO:BP GO:0003013 circulatory system process 3 445 2.03e-01
GO:BP GO:0030517 negative regulation of axon extension 1 41 2.03e-01
GO:BP GO:0045595 regulation of cell differentiation 4 1122 2.03e-01
GO:BP GO:0050919 negative chemotaxis 1 42 2.03e-01
GO:BP GO:0007017 microtubule-based process 2 757 2.05e-01
GO:BP GO:0043949 regulation of cAMP-mediated signaling 1 17 2.05e-01
GO:BP GO:0033048 negative regulation of mitotic sister chromatid segregation 1 45 2.06e-01
GO:BP GO:1901861 regulation of muscle tissue development 1 34 2.06e-01
GO:BP GO:0003341 cilium movement 1 97 2.06e-01
GO:BP GO:1901020 negative regulation of calcium ion transmembrane transporter activity 1 28 2.06e-01
GO:BP GO:0099111 microtubule-based transport 1 192 2.06e-01
GO:BP GO:0051301 cell division 1 569 2.06e-01
GO:BP GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 1 46 2.06e-01
GO:BP GO:0045841 negative regulation of mitotic metaphase/anaphase transition 1 45 2.06e-01
GO:BP GO:0007094 mitotic spindle assembly checkpoint signaling 1 43 2.06e-01
GO:BP GO:0071174 mitotic spindle checkpoint signaling 1 43 2.06e-01
GO:BP GO:0010874 regulation of cholesterol efflux 1 31 2.06e-01
GO:BP GO:0051180 vitamin transport 1 29 2.06e-01
GO:BP GO:0042755 eating behavior 1 16 2.06e-01
GO:BP GO:0051985 negative regulation of chromosome segregation 1 46 2.06e-01
GO:BP GO:0033046 negative regulation of sister chromatid segregation 1 45 2.06e-01
GO:BP GO:2000816 negative regulation of mitotic sister chromatid separation 1 45 2.06e-01
GO:BP GO:0071173 spindle assembly checkpoint signaling 1 43 2.06e-01
GO:BP GO:0009988 cell-cell recognition 1 31 2.06e-01
GO:BP GO:0007286 spermatid development 1 108 2.06e-01
GO:BP GO:1905819 negative regulation of chromosome separation 1 46 2.06e-01
GO:BP GO:0042177 negative regulation of protein catabolic process 1 100 2.06e-01
GO:BP GO:0031577 spindle checkpoint signaling 1 44 2.06e-01
GO:BP GO:0048515 spermatid differentiation 1 114 2.06e-01
GO:BP GO:0007517 muscle organ development 2 279 2.08e-01
GO:BP GO:0003333 amino acid transmembrane transport 1 70 2.08e-01
GO:BP GO:0006612 protein targeting to membrane 1 120 2.08e-01
GO:BP GO:0001755 neural crest cell migration 1 49 2.08e-01
GO:BP GO:1905953 negative regulation of lipid localization 1 31 2.09e-01
GO:BP GO:0090497 mesenchymal cell migration 1 51 2.12e-01
GO:BP GO:0050922 negative regulation of chemotaxis 1 44 2.12e-01
GO:BP GO:0033047 regulation of mitotic sister chromatid segregation 1 51 2.12e-01
GO:BP GO:0048512 circadian behavior 1 30 2.14e-01
GO:BP GO:1901385 regulation of voltage-gated calcium channel activity 1 29 2.15e-01
GO:BP GO:0006767 water-soluble vitamin metabolic process 1 50 2.15e-01
GO:BP GO:0045839 negative regulation of mitotic nuclear division 1 53 2.15e-01
GO:BP GO:0010883 regulation of lipid storage 1 38 2.17e-01
GO:BP GO:0007622 rhythmic behavior 1 32 2.18e-01
GO:BP GO:0050771 negative regulation of axonogenesis 1 59 2.20e-01
GO:BP GO:0010965 regulation of mitotic sister chromatid separation 1 56 2.20e-01
GO:BP GO:0045661 regulation of myoblast differentiation 1 60 2.20e-01
GO:BP GO:2001258 negative regulation of cation channel activity 1 31 2.22e-01
GO:BP GO:0060284 regulation of cell development 1 593 2.27e-01
GO:BP GO:0045776 negative regulation of blood pressure 1 30 2.27e-01
GO:BP GO:0051784 negative regulation of nuclear division 1 56 2.27e-01
GO:BP GO:0051306 mitotic sister chromatid separation 1 59 2.27e-01
GO:BP GO:0015711 organic anion transport 2 270 2.28e-01
GO:BP GO:1903170 negative regulation of calcium ion transmembrane transport 1 35 2.28e-01
GO:BP GO:0045597 positive regulation of cell differentiation 1 618 2.28e-01
GO:BP GO:0033344 cholesterol efflux 1 41 2.29e-01
GO:BP GO:0050890 cognition 2 226 2.31e-01
GO:BP GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 1 36 2.32e-01
GO:BP GO:0046323 glucose import 1 55 2.38e-01
GO:BP GO:0014032 neural crest cell development 1 70 2.45e-01
GO:BP GO:0032371 regulation of sterol transport 1 45 2.45e-01
GO:BP GO:0032374 regulation of cholesterol transport 1 45 2.45e-01
GO:BP GO:0000122 negative regulation of transcription by RNA polymerase II 1 744 2.46e-01
GO:BP GO:1905818 regulation of chromosome separation 1 69 2.46e-01
GO:BP GO:0019933 cAMP-mediated signaling 1 35 2.46e-01
GO:BP GO:0090150 establishment of protein localization to membrane 1 258 2.46e-01
GO:BP GO:0006865 amino acid transport 1 103 2.46e-01
GO:BP GO:0048864 stem cell development 1 75 2.52e-01
GO:BP GO:1905039 carboxylic acid transmembrane transport 1 111 2.53e-01
GO:BP GO:1903825 organic acid transmembrane transport 1 112 2.54e-01
GO:BP GO:0060271 cilium assembly 1 296 2.62e-01
GO:BP GO:0006605 protein targeting 1 310 2.62e-01
GO:BP GO:0014033 neural crest cell differentiation 1 79 2.62e-01
GO:BP GO:0030516 regulation of axon extension 1 82 2.62e-01
GO:BP GO:0051304 chromosome separation 1 75 2.62e-01
GO:BP GO:0051926 negative regulation of calcium ion transport 1 45 2.67e-01
GO:BP GO:0098916 anterograde trans-synaptic signaling 2 490 2.69e-01
GO:BP GO:0007268 chemical synaptic transmission 2 490 2.69e-01
GO:BP GO:0099537 trans-synaptic signaling 2 494 2.71e-01
GO:BP GO:0045445 myoblast differentiation 1 90 2.73e-01
GO:BP GO:0044782 cilium organization 1 317 2.73e-01
GO:BP GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 1 37 2.74e-01
GO:BP GO:0042632 cholesterol homeostasis 1 58 2.74e-01
GO:BP GO:0030071 regulation of mitotic metaphase/anaphase transition 1 87 2.74e-01
GO:BP GO:0045944 positive regulation of transcription by RNA polymerase II 1 918 2.74e-01
GO:BP GO:0043413 macromolecule glycosylation 1 185 2.74e-01
GO:BP GO:0035725 sodium ion transmembrane transport 1 112 2.74e-01
GO:BP GO:0045892 negative regulation of DNA-templated transcription 1 1005 2.74e-01
GO:BP GO:0007018 microtubule-based movement 1 300 2.74e-01
GO:BP GO:0048640 negative regulation of developmental growth 1 94 2.74e-01
GO:BP GO:0044784 metaphase/anaphase transition of cell cycle 1 92 2.74e-01
GO:BP GO:0007091 metaphase/anaphase transition of mitotic cell cycle 1 91 2.74e-01
GO:BP GO:0007010 cytoskeleton organization 2 1186 2.74e-01
GO:BP GO:0032413 negative regulation of ion transmembrane transporter activity 1 52 2.74e-01
GO:BP GO:0042698 ovulation cycle 1 54 2.74e-01
GO:BP GO:0061387 regulation of extent of cell growth 1 96 2.74e-01
GO:BP GO:0008037 cell recognition 1 82 2.74e-01
GO:BP GO:0055092 sterol homeostasis 1 59 2.74e-01
GO:BP GO:0006766 vitamin metabolic process 1 75 2.74e-01
GO:BP GO:0008284 positive regulation of cell population proliferation 1 886 2.74e-01
GO:BP GO:0006486 protein glycosylation 1 185 2.74e-01
GO:BP GO:0099536 synaptic signaling 2 512 2.74e-01
GO:BP GO:0051310 metaphase chromosome alignment 1 87 2.74e-01
GO:BP GO:0051094 positive regulation of developmental process 1 957 2.74e-01
GO:BP GO:1902099 regulation of metaphase/anaphase transition of cell cycle 1 88 2.74e-01
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 1 1014 2.74e-01
GO:BP GO:0010389 regulation of G2/M transition of mitotic cell cycle 1 94 2.74e-01
GO:BP GO:0050795 regulation of behavior 1 41 2.74e-01
GO:BP GO:0050793 regulation of developmental process 5 1813 2.74e-01
GO:BP GO:2001251 negative regulation of chromosome organization 1 89 2.74e-01
GO:BP GO:0019915 lipid storage 1 68 2.74e-01
GO:BP GO:0006836 neurotransmitter transport 1 141 2.74e-01
GO:BP GO:0032410 negative regulation of transporter activity 1 59 2.75e-01
GO:BP GO:0008645 hexose transmembrane transport 1 87 2.75e-01
GO:BP GO:1904659 glucose transmembrane transport 1 84 2.75e-01
GO:BP GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules 1 102 2.75e-01
GO:BP GO:2000026 regulation of multicellular organismal development 1 997 2.75e-01
GO:BP GO:0033045 regulation of sister chromatid segregation 1 99 2.75e-01
GO:BP GO:0070085 glycosylation 1 197 2.75e-01
GO:BP GO:0019218 regulation of steroid metabolic process 1 68 2.75e-01
GO:BP GO:0051303 establishment of chromosome localization 1 93 2.75e-01
GO:BP GO:0048675 axon extension 1 108 2.75e-01
GO:BP GO:0019233 sensory perception of pain 1 39 2.75e-01
GO:BP GO:0051253 negative regulation of RNA metabolic process 1 1112 2.75e-01
GO:BP GO:0030182 neuron differentiation 1 1058 2.75e-01
GO:BP GO:0048468 cell development 2 1950 2.76e-01
GO:BP GO:0019935 cyclic-nucleotide-mediated signaling 1 52 2.76e-01
GO:BP GO:0015749 monosaccharide transmembrane transport 1 88 2.76e-01
GO:BP GO:0008306 associative learning 1 65 2.76e-01
GO:BP GO:0048699 generation of neurons 1 1120 2.78e-01
GO:BP GO:1902749 regulation of cell cycle G2/M phase transition 1 105 2.80e-01
GO:BP GO:1904063 negative regulation of cation transmembrane transport 1 64 2.81e-01
GO:BP GO:0050000 chromosome localization 1 101 2.81e-01
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 1 1203 2.86e-01
GO:BP GO:0007088 regulation of mitotic nuclear division 1 99 2.86e-01
GO:BP GO:0010977 negative regulation of neuron projection development 1 117 2.89e-01
GO:BP GO:0034219 carbohydrate transmembrane transport 1 95 2.89e-01
GO:BP GO:0045596 negative regulation of cell differentiation 2 471 2.89e-01
GO:BP GO:0072657 protein localization to membrane 1 530 2.89e-01
GO:BP GO:1901019 regulation of calcium ion transmembrane transporter activity 1 70 2.91e-01
GO:BP GO:0006814 sodium ion transport 1 158 2.92e-01
GO:BP GO:0051240 positive regulation of multicellular organismal process 1 1103 2.92e-01
GO:BP GO:0034766 negative regulation of monoatomic ion transmembrane transport 1 70 2.92e-01
GO:BP GO:0030301 cholesterol transport 1 81 2.92e-01
GO:BP GO:0120031 plasma membrane bounded cell projection assembly 1 463 2.93e-01
GO:BP GO:0050768 negative regulation of neurogenesis 1 113 2.93e-01
GO:BP GO:0007416 synapse assembly 1 153 2.95e-01
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 1 1305 2.95e-01
GO:BP GO:0030031 cell projection assembly 1 473 2.95e-01
GO:BP GO:0051983 regulation of chromosome segregation 1 121 2.95e-01
GO:BP GO:0022008 neurogenesis 1 1297 2.95e-01
GO:BP GO:0045893 positive regulation of DNA-templated transcription 1 1298 2.95e-01
GO:BP GO:0051961 negative regulation of nervous system development 1 119 2.99e-01
GO:BP GO:0051668 localization within membrane 1 611 3.03e-01
GO:BP GO:0050770 regulation of axonogenesis 1 139 3.03e-01
GO:BP GO:0009101 glycoprotein biosynthetic process 1 251 3.03e-01
GO:BP GO:0007631 feeding behavior 1 51 3.03e-01
GO:BP GO:0000086 G2/M transition of mitotic cell cycle 1 130 3.06e-01
GO:BP GO:0015918 sterol transport 1 93 3.09e-01
GO:BP GO:0007218 neuropeptide signaling pathway 1 36 3.09e-01
GO:BP GO:0051254 positive regulation of RNA metabolic process 1 1425 3.09e-01
GO:BP GO:0007093 mitotic cell cycle checkpoint signaling 1 137 3.10e-01
GO:BP GO:0008643 carbohydrate transport 1 114 3.11e-01
GO:BP GO:0042752 regulation of circadian rhythm 1 93 3.13e-01
GO:BP GO:0051783 regulation of nuclear division 1 115 3.13e-01
GO:BP GO:0032355 response to estradiol 1 79 3.14e-01
GO:BP GO:0033554 cellular response to stress 1 1662 3.14e-01
GO:BP GO:0008283 cell population proliferation 2 2340 3.14e-01
GO:BP GO:0009895 negative regulation of catabolic process 1 287 3.14e-01
GO:BP GO:0032368 regulation of lipid transport 1 91 3.23e-01
GO:BP GO:0044839 cell cycle G2/M phase transition 1 145 3.23e-01
GO:BP GO:0008203 cholesterol metabolic process 1 99 3.23e-01
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 1 1589 3.24e-01
GO:BP GO:1990138 neuron projection extension 1 149 3.24e-01
GO:BP GO:0042176 regulation of protein catabolic process 1 328 3.24e-01
GO:BP GO:0061061 muscle structure development 2 552 3.24e-01
GO:BP GO:0003014 renal system process 1 76 3.25e-01
GO:BP GO:0007267 cell-cell signaling 4 1150 3.26e-01
GO:BP GO:0018193 peptidyl-amino acid modification 1 866 3.26e-01
GO:BP GO:0034763 negative regulation of transmembrane transport 1 96 3.26e-01
GO:BP GO:0007015 actin filament organization 1 372 3.26e-01
GO:BP GO:0008361 regulation of cell size 1 160 3.26e-01
GO:BP GO:0090090 negative regulation of canonical Wnt signaling pathway 1 114 3.26e-01
GO:BP GO:0031345 negative regulation of cell projection organization 1 154 3.26e-01
GO:BP GO:0043271 negative regulation of monoatomic ion transport 1 88 3.26e-01
GO:BP GO:0006886 intracellular protein transport 1 803 3.26e-01
GO:BP GO:1902652 secondary alcohol metabolic process 1 106 3.28e-01
GO:BP GO:0003008 system process 4 1194 3.28e-01
GO:BP GO:0030308 negative regulation of cell growth 1 161 3.28e-01
GO:BP GO:0042127 regulation of cell population proliferation 1 1568 3.31e-01
GO:BP GO:0009100 glycoprotein metabolic process 1 315 3.31e-01
GO:BP GO:0048870 cell motility 2 1169 3.33e-01
GO:BP GO:0016125 sterol metabolic process 1 108 3.33e-01
GO:BP GO:0051129 negative regulation of cellular component organization 2 592 3.34e-01
GO:BP GO:0008277 regulation of G protein-coupled receptor signaling pathway 1 93 3.34e-01
GO:BP GO:0046942 carboxylic acid transport 1 213 3.34e-01
GO:BP GO:0015849 organic acid transport 1 214 3.34e-01
GO:BP GO:1901991 negative regulation of mitotic cell cycle phase transition 1 165 3.41e-01
GO:BP GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 1 165 3.43e-01
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 1 1832 3.43e-01
GO:BP GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 1 71 3.43e-01
GO:BP GO:2001257 regulation of cation channel activity 1 100 3.43e-01
GO:BP GO:1905952 regulation of lipid localization 1 110 3.43e-01
GO:BP GO:0055088 lipid homeostasis 1 116 3.43e-01
GO:BP GO:0000070 mitotic sister chromatid segregation 1 178 3.48e-01
GO:BP GO:0006357 regulation of transcription by RNA polymerase II 1 1764 3.48e-01
GO:BP GO:0050920 regulation of chemotaxis 1 143 3.55e-01
GO:BP GO:0000075 cell cycle checkpoint signaling 1 184 3.55e-01
GO:BP GO:0071897 DNA biosynthetic process 1 174 3.57e-01
GO:BP GO:0007612 learning 1 114 3.57e-01
GO:BP GO:0006366 transcription by RNA polymerase II 1 1852 3.57e-01
GO:BP GO:0007399 nervous system development 1 1886 3.57e-01
GO:BP GO:1901566 organonitrogen compound biosynthetic process 2 1496 3.57e-01
GO:BP GO:0048588 developmental cell growth 1 194 3.58e-01
GO:BP GO:0010557 positive regulation of macromolecule biosynthetic process 1 1896 3.65e-01
GO:BP GO:0030178 negative regulation of Wnt signaling pathway 1 140 3.65e-01
GO:BP GO:0097485 neuron projection guidance 1 177 3.65e-01
GO:BP GO:0007411 axon guidance 1 177 3.65e-01
GO:BP GO:0070887 cellular response to chemical stimulus 1 1857 3.65e-01
GO:BP GO:0031328 positive regulation of cellular biosynthetic process 1 1958 3.65e-01
GO:BP GO:0071702 organic substance transport 6 2133 3.65e-01
GO:BP GO:0051093 negative regulation of developmental process 2 654 3.65e-01
GO:BP GO:0045926 negative regulation of growth 1 204 3.65e-01
GO:BP GO:0060560 developmental growth involved in morphogenesis 1 207 3.65e-01
GO:BP GO:1903829 positive regulation of protein localization 1 392 3.65e-01
GO:BP GO:0048762 mesenchymal cell differentiation 1 205 3.65e-01
GO:BP GO:0030334 regulation of cell migration 2 707 3.65e-01
GO:BP GO:0048863 stem cell differentiation 1 196 3.65e-01
GO:BP GO:0009891 positive regulation of biosynthetic process 1 1972 3.65e-01
GO:BP GO:0070925 organelle assembly 1 828 3.66e-01
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 1 1669 3.68e-01
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 1 1708 3.75e-01
GO:BP GO:0009890 negative regulation of biosynthetic process 1 1721 3.75e-01
GO:BP GO:0045930 negative regulation of mitotic cell cycle 1 209 3.82e-01
GO:BP GO:0000819 sister chromatid segregation 1 217 3.83e-01
GO:BP GO:1903169 regulation of calcium ion transmembrane transport 1 120 3.87e-01
GO:BP GO:2000145 regulation of cell motility 2 741 3.87e-01
GO:BP GO:0051239 regulation of multicellular organismal process 1 2052 3.90e-01
GO:BP GO:0065004 protein-DNA complex assembly 1 171 3.90e-01
GO:BP GO:0008217 regulation of blood pressure 1 114 3.90e-01
GO:BP GO:0010721 negative regulation of cell development 1 190 3.90e-01
GO:BP GO:0005996 monosaccharide metabolic process 1 212 3.94e-01
GO:BP GO:0014706 striated muscle tissue development 1 214 3.96e-01
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 1 2367 3.96e-01
GO:BP GO:0030036 actin cytoskeleton organization 1 566 3.96e-01
GO:BP GO:0098657 import into cell 2 664 3.96e-01
GO:BP GO:0050804 modulation of chemical synaptic transmission 1 343 3.98e-01
GO:BP GO:0099177 regulation of trans-synaptic signaling 1 344 3.98e-01
GO:BP GO:0040012 regulation of locomotion 2 762 3.98e-01
GO:BP GO:0033044 regulation of chromosome organization 1 235 3.99e-01
GO:BP GO:1901988 negative regulation of cell cycle phase transition 1 234 4.06e-01
GO:BP GO:0030154 cell differentiation 2 2942 4.08e-01
GO:BP GO:0048869 cellular developmental process 2 2943 4.08e-01
GO:BP GO:0007623 circadian rhythm 1 160 4.08e-01
GO:BP GO:0031324 negative regulation of cellular metabolic process 1 2069 4.08e-01
GO:BP GO:0006936 muscle contraction 1 266 4.14e-01
GO:BP GO:0060485 mesenchyme development 1 250 4.14e-01
GO:BP GO:0007626 locomotory behavior 1 139 4.16e-01
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 1 2131 4.16e-01
GO:BP GO:0048638 regulation of developmental growth 1 254 4.18e-01
GO:BP GO:0015031 protein transport 1 1366 4.19e-01
GO:BP GO:0046907 intracellular transport 1 1440 4.19e-01
GO:BP GO:0030029 actin filament-based process 1 643 4.20e-01
GO:BP GO:0140014 mitotic nuclear division 1 251 4.20e-01
GO:BP GO:0031325 positive regulation of cellular metabolic process 1 2518 4.20e-01
GO:BP GO:0006355 regulation of DNA-templated transcription 1 2560 4.21e-01
GO:BP GO:2001141 regulation of RNA biosynthetic process 1 2577 4.22e-01
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 1 2607 4.24e-01
GO:BP GO:0043547 positive regulation of GTPase activity 1 211 4.26e-01
GO:BP GO:0040013 negative regulation of locomotion 1 262 4.26e-01
GO:BP GO:1901137 carbohydrate derivative biosynthetic process 1 544 4.26e-01
GO:BP GO:0097435 supramolecular fiber organization 1 666 4.26e-01
GO:BP GO:0006351 DNA-templated transcription 1 2669 4.26e-01
GO:BP GO:0034329 cell junction assembly 1 347 4.26e-01
GO:BP GO:0009892 negative regulation of metabolic process 1 2297 4.26e-01
GO:BP GO:0045184 establishment of protein localization 1 1468 4.27e-01
GO:BP GO:0032774 RNA biosynthetic process 1 2699 4.29e-01
GO:BP GO:0010948 negative regulation of cell cycle process 1 271 4.32e-01
GO:BP GO:0060828 regulation of canonical Wnt signaling pathway 1 214 4.35e-01
GO:BP GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 1 113 4.35e-01
GO:BP GO:0051252 regulation of RNA metabolic process 1 2824 4.42e-01
GO:BP GO:0050808 synapse organization 1 373 4.43e-01
GO:BP GO:0098813 nuclear chromosome segregation 1 264 4.43e-01
GO:BP GO:0006810 transport 2 3294 4.43e-01
GO:BP GO:0009893 positive regulation of metabolic process 1 2846 4.43e-01
GO:BP GO:0001822 kidney development 1 246 4.46e-01
GO:BP GO:0032535 regulation of cellular component size 1 306 4.46e-01
GO:BP GO:0051056 regulation of small GTPase mediated signal transduction 1 249 4.47e-01
GO:BP GO:0015850 organic hydroxy compound transport 1 181 4.51e-01
GO:BP GO:0006950 response to stress 1 2763 4.51e-01
GO:BP GO:0072001 renal system development 1 253 4.52e-01
GO:BP GO:0051924 regulation of calcium ion transport 1 167 4.52e-01
GO:BP GO:0048731 system development 1 2886 4.52e-01
GO:BP GO:0042221 response to chemical 1 2456 4.53e-01
GO:BP GO:1901990 regulation of mitotic cell cycle phase transition 1 305 4.53e-01
GO:BP GO:0003012 muscle system process 1 334 4.53e-01
GO:BP GO:0051234 establishment of localization 2 3453 4.55e-01
GO:BP GO:0040011 locomotion 2 854 4.55e-01
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 1 3059 4.55e-01
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 1 3054 4.55e-01
GO:BP GO:0032412 regulation of monoatomic ion transmembrane transporter activity 1 189 4.56e-01
GO:BP GO:0018130 heterocycle biosynthetic process 1 3115 4.60e-01
GO:BP GO:0120036 plasma membrane bounded cell projection organization 1 1203 4.60e-01
GO:BP GO:0019438 aromatic compound biosynthetic process 1 3116 4.60e-01
GO:BP GO:0051179 localization 4 3983 4.62e-01
GO:BP GO:0022898 regulation of transmembrane transporter activity 1 200 4.64e-01
GO:BP GO:0007611 learning or memory 1 201 4.64e-01
GO:BP GO:0071705 nitrogen compound transport 1 1689 4.64e-01
GO:BP GO:0030030 cell projection organization 1 1236 4.64e-01
GO:BP GO:0010639 negative regulation of organelle organization 1 310 4.64e-01
GO:BP GO:1901362 organic cyclic compound biosynthetic process 1 3221 4.67e-01
GO:BP GO:0098662 inorganic cation transmembrane transport 2 537 4.69e-01
GO:BP GO:0008202 steroid metabolic process 1 203 4.69e-01
GO:BP GO:0062012 regulation of small molecule metabolic process 1 248 4.69e-01
GO:BP GO:0001558 regulation of cell growth 1 352 4.69e-01
GO:BP GO:0060070 canonical Wnt signaling pathway 1 254 4.69e-01
GO:BP GO:0019932 second-messenger-mediated signaling 1 182 4.69e-01
GO:BP GO:0001667 ameboidal-type cell migration 1 358 4.69e-01
GO:BP GO:0051649 establishment of localization in cell 1 1842 4.69e-01
GO:BP GO:0032102 negative regulation of response to external stimulus 1 291 4.69e-01
GO:BP GO:0032409 regulation of transporter activity 1 212 4.75e-01
GO:BP GO:0098655 monoatomic cation transmembrane transport 2 554 4.77e-01
GO:BP GO:0048511 rhythmic process 1 233 4.77e-01
GO:BP GO:0010975 regulation of neuron projection development 1 374 4.77e-01
GO:BP GO:0007409 axonogenesis 1 350 4.77e-01
GO:BP GO:0032880 regulation of protein localization 1 719 4.77e-01
GO:BP GO:0045786 negative regulation of cell cycle 1 337 4.77e-01
GO:BP GO:0043087 regulation of GTPase activity 1 288 4.77e-01
GO:BP GO:0030111 regulation of Wnt signaling pathway 1 274 4.80e-01
GO:BP GO:0140694 non-membrane-bounded organelle assembly 1 364 4.80e-01
GO:BP GO:0006935 chemotaxis 1 264 4.80e-01
GO:BP GO:0019216 regulation of lipid metabolic process 1 251 4.80e-01
GO:BP GO:0030001 metal ion transport 2 568 4.80e-01
GO:BP GO:0051235 maintenance of location 1 263 4.80e-01
GO:BP GO:0006518 peptide metabolic process 1 781 4.80e-01
GO:BP GO:0007275 multicellular organism development 1 3355 4.80e-01
GO:BP GO:0042330 taxis 1 264 4.80e-01
GO:BP GO:0008104 protein localization 2 2128 4.87e-01
GO:BP GO:0070727 cellular macromolecule localization 2 2137 4.88e-01
GO:BP GO:0055085 transmembrane transport 3 1014 4.89e-01
GO:BP GO:0007059 chromosome segregation 1 360 4.90e-01
GO:BP GO:0060537 muscle tissue development 1 347 4.90e-01
GO:BP GO:0006066 alcohol metabolic process 1 263 4.96e-01
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 1 3743 4.96e-01
GO:BP GO:0060341 regulation of cellular localization 1 805 4.97e-01
GO:BP GO:0009410 response to xenobiotic stimulus 1 275 4.97e-01
GO:BP GO:0016049 cell growth 1 416 4.97e-01
GO:BP GO:0051248 negative regulation of protein metabolic process 1 799 4.97e-01
GO:BP GO:1901987 regulation of cell cycle phase transition 1 387 4.97e-01
GO:BP GO:0098660 inorganic ion transmembrane transport 2 582 4.97e-01
GO:BP GO:1904062 regulation of monoatomic cation transmembrane transport 1 232 4.97e-01
GO:BP GO:0061564 axon development 1 388 4.99e-01
GO:BP GO:0090066 regulation of anatomical structure size 1 395 4.99e-01
GO:BP GO:0000280 nuclear division 1 343 4.99e-01
GO:BP GO:0048585 negative regulation of response to stimulus 3 1267 5.04e-01
GO:BP GO:0009894 regulation of catabolic process 1 883 5.04e-01
GO:BP GO:0032501 multicellular organismal process 9 4807 5.04e-01
GO:BP GO:0044772 mitotic cell cycle phase transition 1 411 5.04e-01
GO:BP GO:0070588 calcium ion transmembrane transport 1 221 5.10e-01
GO:BP GO:0016477 cell migration 2 1065 5.10e-01
GO:BP GO:0030163 protein catabolic process 1 906 5.10e-01
GO:BP GO:0030335 positive regulation of cell migration 1 408 5.10e-01
GO:BP GO:1901135 carbohydrate derivative metabolic process 1 841 5.12e-01
GO:BP GO:0051656 establishment of organelle localization 1 397 5.15e-01
GO:BP GO:0050878 regulation of body fluid levels 1 237 5.15e-01
GO:BP GO:0006996 organelle organization 2 2974 5.21e-01
GO:BP GO:2000147 positive regulation of cell motility 1 421 5.25e-01
GO:BP GO:0048856 anatomical structure development 2 4100 5.25e-01
GO:BP GO:0048285 organelle fission 1 387 5.26e-01
GO:BP GO:0034330 cell junction organization 1 586 5.27e-01
GO:BP GO:0006869 lipid transport 1 271 5.27e-01
GO:BP GO:0010468 regulation of gene expression 1 3587 5.27e-01
GO:BP GO:0040017 positive regulation of locomotion 1 429 5.27e-01
GO:BP GO:0048667 cell morphogenesis involved in neuron differentiation 1 451 5.27e-01
GO:BP GO:0007346 regulation of mitotic cell cycle 1 438 5.27e-01
GO:BP GO:0048523 negative regulation of cellular process 1 3773 5.27e-01
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 1 4243 5.33e-01
GO:BP GO:0034220 monoatomic ion transmembrane transport 2 650 5.34e-01
GO:BP GO:0010556 regulation of macromolecule biosynthetic process 1 3702 5.35e-01
GO:BP GO:0010959 regulation of metal ion transport 1 271 5.35e-01
GO:BP GO:0033036 macromolecule localization 1 2448 5.35e-01
GO:BP GO:0033365 protein localization to organelle 1 860 5.38e-01
GO:BP GO:0006812 monoatomic cation transport 2 677 5.38e-01
GO:BP GO:0048522 positive regulation of cellular process 1 4197 5.38e-01
GO:BP GO:0080090 regulation of primary metabolic process 1 4371 5.40e-01
GO:BP GO:0031326 regulation of cellular biosynthetic process 1 3794 5.40e-01
GO:BP GO:0009889 regulation of biosynthetic process 1 3820 5.41e-01
GO:BP GO:0007264 small GTPase mediated signal transduction 1 413 5.41e-01
GO:BP GO:0005975 carbohydrate metabolic process 1 439 5.41e-01
GO:BP GO:0040008 regulation of growth 1 493 5.41e-01
GO:BP GO:0043603 amide metabolic process 1 1003 5.41e-01
GO:BP GO:0048519 negative regulation of biological process 1 4026 5.47e-01
GO:BP GO:0198738 cell-cell signaling by wnt 1 380 5.47e-01
GO:BP GO:0120035 regulation of plasma membrane bounded cell projection organization 1 529 5.47e-01
GO:BP GO:0051051 negative regulation of transport 1 317 5.47e-01
GO:BP GO:0010876 lipid localization 1 309 5.47e-01
GO:BP GO:0044770 cell cycle phase transition 1 496 5.47e-01
GO:BP GO:0036211 protein modification process 1 2751 5.47e-01
GO:BP GO:0048812 neuron projection morphogenesis 1 500 5.47e-01
GO:BP GO:0016055 Wnt signaling pathway 1 379 5.47e-01
GO:BP GO:0120039 plasma membrane bounded cell projection morphogenesis 1 515 5.51e-01
GO:BP GO:0048589 developmental growth 1 522 5.51e-01
GO:BP GO:0031344 regulation of cell projection organization 1 542 5.51e-01
GO:BP GO:0048858 cell projection morphogenesis 1 519 5.52e-01
GO:BP GO:0006816 calcium ion transport 1 275 5.57e-01
GO:BP GO:0032502 developmental process 2 4445 5.61e-01
GO:BP GO:0032990 cell part morphogenesis 1 539 5.62e-01
GO:BP GO:0048518 positive regulation of biological process 1 4566 5.62e-01
GO:BP GO:0043412 macromolecule modification 1 2948 5.64e-01
GO:BP GO:0051641 cellular localization 1 2822 5.66e-01
GO:BP GO:0034765 regulation of monoatomic ion transmembrane transport 1 296 5.66e-01
GO:BP GO:0051345 positive regulation of hydrolase activity 1 412 5.66e-01
GO:BP GO:0051640 organelle localization 1 521 5.69e-01
GO:BP GO:0098609 cell-cell adhesion 1 599 5.73e-01
GO:BP GO:1901565 organonitrogen compound catabolic process 1 1151 5.73e-01
GO:BP GO:0009057 macromolecule catabolic process 1 1215 5.80e-01
GO:BP GO:0051276 chromosome organization 1 533 5.85e-01
GO:BP GO:1901615 organic hydroxy compound metabolic process 1 375 5.90e-01
GO:BP GO:0008015 blood circulation 1 372 5.90e-01
GO:BP GO:0031323 regulation of cellular metabolic process 1 4563 5.91e-01
GO:BP GO:0060255 regulation of macromolecule metabolic process 1 4593 5.94e-01
GO:BP GO:0006811 monoatomic ion transport 1 788 5.97e-01
GO:BP GO:0050877 nervous system process 1 628 5.98e-01
GO:BP GO:0009059 macromolecule biosynthetic process 2 5148 6.01e-01
GO:BP GO:1902532 negative regulation of intracellular signal transduction 1 445 6.01e-01
GO:BP GO:0009968 negative regulation of signal transduction 2 1017 6.01e-01
GO:BP GO:0032989 cellular component morphogenesis 1 627 6.01e-01
GO:BP GO:0016070 RNA metabolic process 1 3573 6.01e-01
GO:BP GO:0010564 regulation of cell cycle process 1 622 6.27e-01
GO:BP GO:0019222 regulation of metabolic process 1 4998 6.30e-01
GO:BP GO:0043269 regulation of monoatomic ion transport 1 369 6.35e-01
GO:BP GO:0051716 cellular response to stimulus 1 4929 6.35e-01
GO:BP GO:0008285 negative regulation of cell population proliferation 1 643 6.35e-01
GO:BP GO:0007420 brain development 1 546 6.35e-01
GO:BP GO:0022603 regulation of anatomical structure morphogenesis 1 680 6.35e-01
GO:BP GO:0032879 regulation of localization 3 1570 6.37e-01
GO:BP GO:1903047 mitotic cell cycle process 1 689 6.37e-01
GO:BP GO:0090304 nucleic acid metabolic process 1 4018 6.37e-01
GO:BP GO:0034762 regulation of transmembrane transport 1 392 6.37e-01
GO:BP GO:0023057 negative regulation of signaling 2 1090 6.42e-01
GO:BP GO:0010648 negative regulation of cell communication 2 1088 6.42e-01
GO:BP GO:0065003 protein-containing complex assembly 1 1320 6.44e-01
GO:BP GO:0060322 head development 1 588 6.52e-01
GO:BP GO:0040007 growth 1 737 6.56e-01
GO:BP GO:0000902 cell morphogenesis 1 740 6.67e-01
GO:BP GO:0007610 behavior 1 439 6.69e-01
GO:BP GO:0006139 nucleobase-containing compound metabolic process 1 4423 6.69e-01
GO:BP GO:0031175 neuron projection development 1 774 6.78e-01
GO:BP GO:0046483 heterocycle metabolic process 1 4537 6.81e-01
GO:BP GO:0044249 cellular biosynthetic process 2 5813 6.82e-01
GO:BP GO:0006725 cellular aromatic compound metabolic process 1 4561 6.83e-01
GO:BP GO:0019752 carboxylic acid metabolic process 1 684 6.88e-01
GO:BP GO:0071824 protein-DNA complex organization 1 711 6.88e-01
GO:BP GO:1901576 organic substance biosynthetic process 2 5875 6.88e-01
GO:BP GO:0043436 oxoacid metabolic process 1 699 6.93e-01
GO:BP GO:0009058 biosynthetic process 2 5912 6.93e-01
GO:BP GO:0006082 organic acid metabolic process 1 703 6.93e-01
GO:BP GO:0000278 mitotic cell cycle 1 815 6.93e-01
GO:BP GO:1901360 organic cyclic compound metabolic process 1 4713 6.93e-01
GO:BP GO:0032101 regulation of response to external stimulus 1 690 6.94e-01
GO:BP GO:0019538 protein metabolic process 1 4202 7.03e-01
GO:BP GO:0009888 tissue development 2 1425 7.03e-01
GO:BP GO:0034641 cellular nitrogen compound metabolic process 1 4913 7.03e-01
GO:BP GO:0051241 negative regulation of multicellular organismal process 1 744 7.05e-01
GO:BP GO:0048513 animal organ development 3 2156 7.10e-01
GO:BP GO:1901575 organic substance catabolic process 1 1731 7.14e-01
GO:BP GO:0007155 cell adhesion 1 996 7.15e-01
GO:BP GO:0043933 protein-containing complex organization 1 1964 7.15e-01
GO:BP GO:0048666 neuron development 1 873 7.15e-01
GO:BP GO:0051336 regulation of hydrolase activity 1 680 7.20e-01
GO:BP GO:0044281 small molecule metabolic process 2 1386 7.20e-01
GO:BP GO:0050896 response to stimulus 1 5721 7.20e-01
GO:BP GO:0007417 central nervous system development 1 750 7.30e-01
GO:BP GO:0006259 DNA metabolic process 1 886 7.30e-01
GO:BP GO:1902531 regulation of intracellular signal transduction 2 1318 7.32e-01
GO:BP GO:0010467 gene expression 1 4733 7.32e-01
GO:BP GO:0051246 regulation of protein metabolic process 1 1895 7.42e-01
GO:BP GO:0023051 regulation of signaling 4 2560 7.49e-01
GO:BP GO:0051726 regulation of cell cycle 1 941 7.50e-01
GO:BP GO:0010646 regulation of cell communication 4 2567 7.50e-01
GO:BP GO:0051049 regulation of transport 2 1268 7.50e-01
GO:BP GO:0035556 intracellular signal transduction 3 2036 7.51e-01
GO:BP GO:0048878 chemical homeostasis 1 689 7.59e-01
GO:BP GO:0033993 response to lipid 1 594 7.60e-01
GO:BP GO:0033043 regulation of organelle organization 1 1001 7.60e-01
GO:BP GO:0022607 cellular component assembly 1 2459 7.60e-01
GO:BP GO:0014070 response to organic cyclic compound 1 634 7.60e-01
GO:BP GO:0043085 positive regulation of catalytic activity 1 815 7.60e-01
GO:BP GO:1901564 organonitrogen compound metabolic process 1 4919 7.60e-01
GO:BP GO:0009056 catabolic process 1 2108 7.65e-01
GO:BP GO:0007600 sensory perception 1 259 7.70e-01
GO:BP GO:0044092 negative regulation of molecular function 1 730 7.72e-01
GO:BP GO:0044085 cellular component biogenesis 1 2722 7.79e-01
GO:BP GO:0051128 regulation of cellular component organization 2 1981 7.79e-01
GO:BP GO:0022402 cell cycle process 1 1078 7.85e-01
GO:BP GO:0009966 regulation of signal transduction 3 2271 8.26e-01
GO:BP GO:0006807 nitrogen compound metabolic process 2 7431 8.32e-01
GO:BP GO:0048583 regulation of response to stimulus 4 2877 8.43e-01
GO:BP GO:0043170 macromolecule metabolic process 2 7084 8.57e-01
GO:BP GO:0023052 signaling 7 4134 8.57e-01
GO:BP GO:0007186 G protein-coupled receptor signaling pathway 1 386 8.57e-01
GO:BP GO:0044093 positive regulation of molecular function 1 1132 8.57e-01
GO:BP GO:0006629 lipid metabolic process 1 989 8.57e-01
GO:BP GO:0007154 cell communication 7 4210 8.69e-01
GO:BP GO:0050794 regulation of cellular process 1 7632 8.93e-01
GO:BP GO:0007049 cell cycle 1 1515 8.93e-01
GO:BP GO:0044238 primary metabolic process 2 7788 8.95e-01
GO:BP GO:0065009 regulation of molecular function 2 1905 8.99e-01
GO:BP GO:0050790 regulation of catalytic activity 1 1349 9.03e-01
GO:BP GO:0042592 homeostatic process 1 1189 9.05e-01
GO:BP GO:0007166 cell surface receptor signaling pathway 2 1889 9.12e-01
GO:BP GO:0044237 cellular metabolic process 2 7562 9.22e-01
GO:BP GO:0050789 regulation of biological process 1 8017 9.26e-01
GO:BP GO:0016043 cellular component organization 2 5106 9.27e-01
GO:BP GO:1901700 response to oxygen-containing compound 1 1219 9.35e-01
GO:BP GO:0071840 cellular component organization or biogenesis 2 5307 9.36e-01
GO:BP GO:0065008 regulation of biological quality 2 2085 9.37e-01
GO:BP GO:0009653 anatomical structure morphogenesis 1 1952 9.39e-01
GO:BP GO:0009605 response to external stimulus 1 1635 9.39e-01
GO:BP GO:0065007 biological regulation 1 8282 9.47e-01
GO:BP GO:0007165 signal transduction 5 3803 9.55e-01
GO:BP GO:0010033 response to organic substance 1 1942 9.90e-01
GO:BP GO:0008150 biological_process 1 12027 1.00e+00
GO:BP GO:0071704 organic substance metabolic process 1 8176 1.00e+00
GO:BP GO:0008152 metabolic process 1 8522 1.00e+00
GO:BP GO:0009987 cellular process 1 11410 1.00e+00
KEGG KEGG:05202 Transcriptional misregulation in cancer 1 128 7.07e-02
KEGG KEGG:05215 Prostate cancer 1 86 7.07e-02
KEGG KEGG:00510 N-Glycan biosynthesis 1 48 7.29e-02
KEGG KEGG:05014 Amyotrophic lateral sclerosis 1 303 1.56e-01
KEGG KEGG:05016 Huntington disease 1 256 1.56e-01
KEGG KEGG:05022 Pathways of neurodegeneration - multiple diseases 1 385 1.68e-01
KEGG KEGG:04360 Axon guidance 1 162 2.12e-01
KEGG KEGG:04080 Neuroactive ligand-receptor interaction 1 108 4.86e-01
KEGG KEGG:01100 Metabolic pathways 1 1146 5.69e-01
KEGG KEGG:00000 KEGG root term 1 5548 6.01e-01
TRZnomtable24h %>%
  filter(source=="KEGG") %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "Enrichment of KEGG terms using nominal pvalue TRZ 24hour genes in my data") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")
Enrichment of KEGG terms using nominal pvalue TRZ 24hour genes in my data
source term_id term_name intersection_size term_size p_value
KEGG KEGG:05202 Transcriptional misregulation in cancer 1 128 7.07e-02
KEGG KEGG:05215 Prostate cancer 1 86 7.07e-02
KEGG KEGG:00510 N-Glycan biosynthesis 1 48 7.29e-02
KEGG KEGG:05014 Amyotrophic lateral sclerosis 1 303 1.56e-01
KEGG KEGG:05016 Huntington disease 1 256 1.56e-01
KEGG KEGG:05022 Pathways of neurodegeneration - multiple diseases 1 385 1.68e-01
KEGG KEGG:04360 Axon guidance 1 162 2.12e-01
KEGG KEGG:04080 Neuroactive ligand-receptor interaction 1 108 4.86e-01
KEGG KEGG:01100 Metabolic pathways 1 1146 5.69e-01
KEGG KEGG:00000 KEGG root term 1 5548 6.01e-01
# DAgostres3 <- readRDS("data/DEG-GO/DAgostres3.RDS")
# DAgostres24 <- readRDS("data/DAgostres24.RDS")
# DXgostres <- readRDS("data/DEG-GO/DXgostres.RDS")
# DXgostres24 <- readRDS("data/DEG-GO/DXgostres24.RDS")
# EPgostres <- readRDS("data/DEG-GO/EPgostres.RDS")
# EPgostres24 <- readRDS("data/DEG-GO/EPgostres24.RDS")
# MTgostres <- readRDS("data/DEG-GO/MTgostres.RDS")
# MTgostres24 <- readRDS("data/DEG-GO/MTgostres24.RDS")
# DDEgostres24only <- readRDS("data/DEG-GO/DDEgostres24only.RDS")
# DDEgostres3only <- readRDS("data/DEG-GO/DDEgostres3only.RDS")
# DDEMgostres3 <- readRDS("data/DEG-GO/DDEMgostres3.RDS")
# DDEMgostres24 <- readRDS("data/DEG-GO/DDEMgostres24.RDS")
# TRZresgenes24h  <- readRDS("data/DEG-GO/TRZresgenes24h.RDS") 
# TRZresgenes3h  <- readRDS("data/DEG-GO/TRZresgenes3h.RDS") 
# saveRDS(list3hr,"data/DEG-GO/list3hr.RDS")
# saveRDS(list24hr,"data/DEG-GO/list24hr.RDS")
# list3hr <- list(DAgostres3=DAgostres3,DXgostres=DXgostres,EPgostres=EPgostres,MTgostres=MTgostres,TRZresgenes3h=TRZresgenes3h,DDEgostres3only=DDEgostres3only,DDEMgostres3=DDEMgostres3)
#  list24hr <- list(DAgostres24=DAgostres24,DXgostres24=DXgostres24,EPgostres24=EPgostres24,MTgostres24=MTgostres24,TRZresgenes243h=TRZresgenes24h,DDEgostres24only=DDEgostres24only,DDEMgostres24=DDEMgostres24)

list3hr <- readRDS("data/DEG-GO/list3hr.RDS")
list24hr <- readRDS("data/DEG-GO/list24hr.RDS")
KEGGtrz3 <- c("KEGG:05202", "KEGG:04115", "KEGG:05223", "KEGG:05212","KEGG:05222")
KEGGtrz24 <- c("KEGG:05202", "KEGG:05215", "KEGG:00510")
# testframe <- lapply(list3hr, `[`,'result')

hr3_results <- list3hr |> 
  map(~ .x$result |> dplyr::select(p_value,term_id,term_name,intersection_size))
hr24_results <- list24hr |> 
  map(~ .x$result |> dplyr::select(p_value,term_id,term_name,,intersection_size))

table_3hr <- list_rbind(hr3_results,names_to = "set")%>%
  mutate(log_val = -log10(p_value)) %>% 
  dplyr::filter(term_id %in% KEGGtrz3) %>% 
  mutate(treatment = case_when(set =="DAgostres3"~"DNR",set=="DXgostres" ~ "DOX",set=="EPgostres"~"EPI",set=="MTgostres"~"MTX",set=="TRZresgenes3h"~"TRZ",set=="DDEgostres23only"~"AC",set=="DDEMgostres3"~"TOP2i"))


table_24hr <- list_rbind(hr24_results,names_to = "set") %>%
  mutate(log_val = -log10(p_value))%>% 
  dplyr::filter(term_id %in% KEGGtrz24) %>% 
  mutate(treatment = case_when(set =="DAgostres24"~"DNR",set=="DXgostres24" ~ "DOX",set=="EPgostres24"~"EPI",set=="MTgostres24"~"MTX",set=="TRZresgenes243h"~"TRZ",set=="DDEgostres24only"~"AC",set=="DDEMgostres24"~"TOP2i"))


hr3_results[["TRZresgenes3h"]]  %>% 
    mutate(log_val = -log10(p_value)) %>% 
  dplyr::filter(str_detect(term_id,"^KEGG:")) %>% 
  slice_min(., n=5,order_by=p_value) %>%
    ggplot(., aes(x = log_val, y =reorder(term_name,p_value),col=intersection_size)) +
    geom_point(aes(size = intersection_size)) +
    scale_y_discrete(labels = scales::label_wrap(30))+
  geom_vline(xintercept = (-log10(0.05)), col="red")+
    guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
    ggtitle('TRZ 3 hour nominal DE\n KEGG pathway enrichment') +
    xlab(expression(" -"~log[10]~("nominal p-value")))+
    ylab("KEGG")+
    theme_bw()+
    theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
        axis.title = element_text(size = 15, color = "black"),
        axis.ticks = element_line(linewidth = 1.5),
        # axis.line = element_line(linewidth = 1.5),
        axis.text = element_text(size = 10, color = "black", angle = 0),
        strip.text.x = element_text(size = 12, color = "black", face = "bold"))

hr24_results[["TRZresgenes243h"]]  %>% 
    mutate(log_val = -log10(p_value)) %>% 
  dplyr::filter(str_detect(term_id,"^KEGG:")) %>% 
  slice_min(., n=5,order_by=p_value) %>%
    ggplot(., aes(x = log_val, y =reorder(term_name,p_value), col=intersection_size)) +
    geom_point(aes(size = intersection_size)) +
    scale_y_discrete(labels = scales::label_wrap(30))+
   geom_vline(xintercept = (-log10(0.05)), col="red")+
    guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
    ggtitle('TRZ 24 hour nominal DE\n KEGG pathway enrichment') +
    xlab(expression(" -"~log[10]~("nominal p-value")))+
    ylab("KEGG")+
    theme_bw()+
    theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
        axis.title = element_text(size = 15, color = "black"),
        axis.ticks = element_line(linewidth = 1.5),
        # axis.line = element_line(linewidth = 1.5),
        axis.text = element_text(size = 10, color = "black", angle = 0),
        strip.text.x = element_text(size = 12, color = "black", face = "bold"))

hr3_results[["TRZresgenes3h"]]  %>% 
    mutate(log_val = -log10(p_value)) %>% 
  dplyr::filter(str_detect(term_id,"^GO:")) %>% 
  slice_min(., n=5,order_by=p_value) %>%
    ggplot(., aes(x = log_val, y =reorder(term_name,p_value),col=intersection_size)) +
    geom_point(aes(size = intersection_size)) +
    scale_y_discrete(labels = scales::label_wrap(30))+
  geom_vline(xintercept = (-log10(0.05)), col="red")+
    guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
    ggtitle('TRZ 3 hour nominal DE\n GO:BP enrichment') +
    xlab(expression(" -"~log[10]~("nominal p-value")))+
    ylab("KEGG")+
    theme_bw()+
    theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
        axis.title = element_text(size = 15, color = "black"),
        axis.ticks = element_line(linewidth = 1.5),
        axis.line = element_line(linewidth = 1.5),
        axis.text = element_text(size = 10, color = "black", angle = 0),
        strip.text.x = element_text(size = 12, color = "black", face = "bold"))

hr24_results[["TRZresgenes243h"]]  %>% 
    mutate(log_val = -log10(p_value)) %>% 
  dplyr::filter(str_detect(term_id,"^GO:")) %>% 
  slice_min(., n=4,order_by=p_value) %>%
    ggplot(., aes(x = log_val, y =reorder(term_name,p_value), col=intersection_size)) +
    geom_point(aes(size = intersection_size)) +
    scale_y_discrete(labels = scales::label_wrap(30))+
  geom_vline(xintercept = (-log10(0.05)), col="red")+
    guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
    ggtitle('TRZ 24 hour nominal DE\n GO:BP enrichment') +
    xlab(expression(" -"~log[10]~("nominal p-value")))+
    ylab("KEGG")+
    theme_bw()+
    theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
        axis.title = element_text(size = 15, color = "black"),
        axis.ticks = element_line(linewidth = 1.5),
        # axis.line = element_line(linewidth = 1.5),
        axis.text = element_text(size = 10, color = "black", angle = 0),
        strip.text.x = element_text(size = 12, color = "black", face = "bold"))