GO_after_comments

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Last updated: 2023-12-19

Checks: 6 1

Knit directory: Cardiotoxicity/

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Repository version: e993745

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Note that any generated files, e.g. HTML, png, CSS, etc., are not included in this status report because it is ok for generated content to have uncommitted changes.

---

These are the previous versions of the repository in which changes were made to the R Markdown (analysis/GO_after_comments.Rmd) and HTML (docs/GO_after_comments.html) files. If you’ve configured a remote Git repository (see ?wflow_git_remote), click on the hyperlinks in the table below to view the files as they were in that past version.

File	Version	Author	Date	Message
Rmd	e993745	reneeisnowhere	2023-12-19	Adding pathway enrichment plots
html	b442590	reneeisnowhere	2023-11-21	Build site.
Rmd	b464f89	reneeisnowhere	2023-11-21	updates to links again
html	fd6d33c	reneeisnowhere	2023-11-21	Build site.
Rmd	cbefbd1	reneeisnowhere	2023-11-21	adding links

---

library(tidyverse)
library(ggsignif)
library(cowplot)
library(ggpubr)
library(scales)
library(sjmisc)
library(kableExtra)
library(broom)
library(biomaRt)
library(RColorBrewer)
library(gprofiler2)
library(qvalue)

FC_mine <- readRDS("data/toplistall.RDS")
TRZ_list <- FC_mine %>% 
  filter(id=="TRZ",P.Value < 0.05) #%>% 
backGL <- read_csv("data/backGL.txt", 
    col_types = cols(...1 = col_skip()))

TRZ_list3h <- FC_mine %>% 
  filter(id=="TRZ",P.Value < 0.05, time == "3_hours")
TRZ_list24h <- FC_mine %>% 
  filter(id=="TRZ",P.Value < 0.05, time == "24_hours")

TRZ_listqvalue <- FC_mine %>% 
  filter(id=="TRZ", time=="24_hours") %>% 
  dplyr::select(ENTREZID,P.Value)

qobj <- qvalue(TRZ_listqvalue$P.Value)
hist(qobj)

plot(qobj)

TRZ nom de (3 & 24 hour)

# TRZresgenes <- gost(query = TRZ_list$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = TRUE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = backGL$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(TRZresgenes,"data/DEG-GO/TRZresgenes.RDS")
TRZresgenes <- readRDS("data/DEG-GO/TRZresgenes.RDS")

TRZnom <- gostplot(TRZresgenes, capped = FALSE, interactive = TRUE)
TRZnom

TRZnomtable <- TRZresgenes$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

TRZnomtable %>%
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:1902746	regulation of lens fiber cell differentiation	2	8	6.14e-02
GO:BP	GO:0098722	asymmetric stem cell division	1	2	6.14e-02
GO:BP	GO:0042078	germ-line stem cell division	1	2	6.14e-02
GO:BP	GO:0098728	germline stem cell asymmetric division	1	2	6.14e-02
GO:BP	GO:1902747	negative regulation of lens fiber cell differentiation	2	5	6.14e-02
GO:BP	GO:0048133	male germ-line stem cell asymmetric division	1	2	6.14e-02
GO:BP	GO:0035810	positive regulation of urine volume	2	10	6.14e-02
GO:BP	GO:0044849	estrous cycle	2	14	7.09e-02
GO:BP	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	2	15	8.54e-02
GO:BP	GO:1900745	positive regulation of p38MAPK cascade	2	22	8.66e-02
GO:BP	GO:0034599	cellular response to oxidative stress	3	218	8.66e-02
GO:BP	GO:1901386	negative regulation of voltage-gated calcium channel activity	2	14	8.66e-02
GO:BP	GO:0035809	regulation of urine volume	2	14	8.66e-02
GO:BP	GO:0030857	negative regulation of epithelial cell differentiation	2	31	9.28e-02
GO:BP	GO:0098708	glucose import across plasma membrane	1	5	9.28e-02
GO:BP	GO:0120162	positive regulation of cold-induced thermogenesis	3	72	9.28e-02
GO:BP	GO:0098739	import across plasma membrane	3	130	9.28e-02
GO:BP	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	2	28	9.28e-02
GO:BP	GO:0150104	transport across blood-brain barrier	2	72	9.28e-02
GO:BP	GO:0045210	FasL biosynthetic process	1	1	9.28e-02
GO:BP	GO:1900744	regulation of p38MAPK cascade	2	32	9.28e-02
GO:BP	GO:0098704	carbohydrate import across plasma membrane	1	5	9.28e-02
GO:BP	GO:1901385	regulation of voltage-gated calcium channel activity	2	29	9.28e-02
GO:BP	GO:0019249	lactate biosynthetic process	1	3	9.28e-02
GO:BP	GO:0018345	protein palmitoylation	1	30	9.28e-02
GO:BP	GO:0140271	hexose import across plasma membrane	1	5	9.28e-02
GO:BP	GO:0097167	circadian regulation of translation	1	4	9.28e-02
GO:BP	GO:0051764	actin crosslink formation	1	9	9.28e-02
GO:BP	GO:0070306	lens fiber cell differentiation	2	30	9.28e-02
GO:BP	GO:0043949	regulation of cAMP-mediated signaling	2	17	9.28e-02
GO:BP	GO:0007281	germ cell development	2	194	9.28e-02
GO:BP	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	1	7	9.28e-02
GO:BP	GO:0042918	alkanesulfonate transport	1	6	9.28e-02
GO:BP	GO:0048762	mesenchymal cell differentiation	4	205	9.28e-02
GO:BP	GO:0038066	p38MAPK cascade	2	42	9.28e-02
GO:BP	GO:0008356	asymmetric cell division	1	14	9.28e-02
GO:BP	GO:0036159	inner dynein arm assembly	1	8	9.28e-02
GO:BP	GO:0089718	amino acid import across plasma membrane	2	38	9.28e-02
GO:BP	GO:0051939	gamma-aminobutyric acid import	1	3	9.28e-02
GO:BP	GO:0051946	regulation of glutamate uptake involved in transmission of nerve impulse	1	3	9.28e-02
GO:BP	GO:0060251	regulation of glial cell proliferation	1	26	9.28e-02
GO:BP	GO:0060252	positive regulation of glial cell proliferation	1	14	9.28e-02
GO:BP	GO:0010719	negative regulation of epithelial to mesenchymal transition	2	29	9.28e-02
GO:BP	GO:0006979	response to oxidative stress	3	328	9.28e-02
GO:BP	GO:0060485	mesenchyme development	4	250	9.28e-02
GO:BP	GO:0061643	chemorepulsion of axon	1	6	9.28e-02
GO:BP	GO:0062197	cellular response to chemical stress	3	269	9.28e-02
GO:BP	GO:0051941	regulation of amino acid uptake involved in synaptic transmission	1	3	9.28e-02
GO:BP	GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	1	21	9.28e-02
GO:BP	GO:0022412	cellular process involved in reproduction in multicellular organism	2	255	9.28e-02
GO:BP	GO:1904059	regulation of locomotor rhythm	1	3	9.28e-02
GO:BP	GO:0010232	vascular transport	2	72	9.28e-02
GO:BP	GO:1990708	conditioned place preference	1	2	9.28e-02
GO:BP	GO:0015734	taurine transport	1	6	9.28e-02
GO:BP	GO:1904350	regulation of protein catabolic process in the vacuole	1	13	9.28e-02
GO:BP	GO:2001258	negative regulation of cation channel activity	2	31	9.28e-02
GO:BP	GO:0014015	positive regulation of gliogenesis	1	44	9.28e-02
GO:BP	GO:0001837	epithelial to mesenchymal transition	3	139	9.28e-02
GO:BP	GO:0014009	glial cell proliferation	1	40	9.28e-02
GO:BP	GO:1905165	regulation of lysosomal protein catabolic process	1	11	9.28e-02
GO:BP	GO:1903170	negative regulation of calcium ion transmembrane transport	2	35	9.28e-02
GO:BP	GO:0015757	galactose transmembrane transport	1	4	9.28e-02
GO:BP	GO:1904351	negative regulation of protein catabolic process in the vacuole	1	5	9.28e-02
GO:BP	GO:1902966	positive regulation of protein localization to early endosome	1	10	9.28e-02
GO:BP	GO:1902965	regulation of protein localization to early endosome	1	10	9.28e-02
GO:BP	GO:0017145	stem cell division	1	25	9.28e-02
GO:BP	GO:1902946	protein localization to early endosome	1	12	9.28e-02
GO:BP	GO:0003018	vascular process in circulatory system	3	198	9.28e-02
GO:BP	GO:0010799	regulation of peptidyl-threonine phosphorylation	2	35	9.28e-02
GO:BP	GO:0015800	acidic amino acid transport	2	39	9.28e-02
GO:BP	GO:0018230	peptidyl-L-cysteine S-palmitoylation	1	21	9.28e-02
GO:BP	GO:1905166	negative regulation of lysosomal protein catabolic process	1	5	9.28e-02
GO:BP	GO:0120161	regulation of cold-induced thermogenesis	3	115	9.49e-02
GO:BP	GO:0045226	extracellular polysaccharide biosynthetic process	1	2	9.49e-02
GO:BP	GO:1905668	positive regulation of protein localization to endosome	1	14	9.49e-02
GO:BP	GO:1900625	positive regulation of monocyte aggregation	1	3	9.49e-02
GO:BP	GO:0048232	male gamete generation	2	346	9.49e-02
GO:BP	GO:0046379	extracellular polysaccharide metabolic process	1	2	9.49e-02
GO:BP	GO:0007283	spermatogenesis	2	333	9.49e-02
GO:BP	GO:0007288	sperm axoneme assembly	1	20	9.49e-02
GO:BP	GO:1905666	regulation of protein localization to endosome	1	15	9.49e-02
GO:BP	GO:1900623	regulation of monocyte aggregation	1	3	9.49e-02
GO:BP	GO:0106106	cold-induced thermogenesis	3	116	9.54e-02
GO:BP	GO:0070345	negative regulation of fat cell proliferation	1	4	9.57e-02
GO:BP	GO:0045666	positive regulation of neuron differentiation	1	63	9.57e-02
GO:BP	GO:0018198	peptidyl-cysteine modification	1	41	9.57e-02
GO:BP	GO:0000379	tRNA-type intron splice site recognition and cleavage	1	3	9.96e-02
GO:BP	GO:0014013	regulation of gliogenesis	1	66	9.96e-02
GO:BP	GO:0003013	circulatory system process	4	445	1.04e-01
GO:BP	GO:0006044	N-acetylglucosamine metabolic process	1	16	1.04e-01
GO:BP	GO:0000271	polysaccharide biosynthetic process	2	54	1.04e-01
GO:BP	GO:0019933	cAMP-mediated signaling	2	35	1.04e-01
GO:BP	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway	1	3	1.04e-01
GO:BP	GO:1900127	positive regulation of hyaluronan biosynthetic process	1	4	1.04e-01
GO:BP	GO:1990845	adaptive thermogenesis	3	127	1.04e-01
GO:BP	GO:0003333	amino acid transmembrane transport	2	70	1.04e-01
GO:BP	GO:0015812	gamma-aminobutyric acid transport	1	11	1.04e-01
GO:BP	GO:0120316	sperm flagellum assembly	1	27	1.04e-01
GO:BP	GO:0070286	axonemal dynein complex assembly	1	21	1.04e-01
GO:BP	GO:0051935	glutamate reuptake	1	4	1.04e-01
GO:BP	GO:0070837	dehydroascorbic acid transport	1	7	1.04e-01
GO:BP	GO:0090500	endocardial cushion to mesenchymal transition	1	4	1.04e-01
GO:BP	GO:0032328	alanine transport	1	13	1.04e-01
GO:BP	GO:1905146	lysosomal protein catabolic process	1	19	1.04e-01
GO:BP	GO:0051926	negative regulation of calcium ion transport	2	45	1.05e-01
GO:BP	GO:0007276	gamete generation	2	465	1.05e-01
GO:BP	GO:0003351	epithelial cilium movement involved in extracellular fluid movement	1	30	1.05e-01
GO:BP	GO:0070373	negative regulation of ERK1 and ERK2 cascade	2	58	1.05e-01
GO:BP	GO:0034089	establishment of meiotic sister chromatid cohesion	1	4	1.05e-01
GO:BP	GO:0007039	protein catabolic process in the vacuole	1	22	1.07e-01
GO:BP	GO:0046330	positive regulation of JNK cascade	2	71	1.07e-01
GO:BP	GO:0006858	extracellular transport	1	33	1.07e-01
GO:BP	GO:0019852	L-ascorbic acid metabolic process	1	10	1.07e-01
GO:BP	GO:1901334	lactone metabolic process	1	10	1.07e-01
GO:BP	GO:0060437	lung growth	1	4	1.07e-01
GO:BP	GO:0042752	regulation of circadian rhythm	2	93	1.07e-01
GO:BP	GO:0010887	negative regulation of cholesterol storage	1	8	1.07e-01
GO:BP	GO:1901071	glucosamine-containing compound metabolic process	1	19	1.08e-01
GO:BP	GO:0070487	monocyte aggregation	1	4	1.08e-01
GO:BP	GO:0002036	regulation of L-glutamate import across plasma membrane	1	6	1.08e-01
GO:BP	GO:0042698	ovulation cycle	2	54	1.08e-01
GO:BP	GO:1901842	negative regulation of high voltage-gated calcium channel activity	1	4	1.09e-01
GO:BP	GO:0001659	temperature homeostasis	3	135	1.09e-01
GO:BP	GO:0036010	protein localization to endosome	1	28	1.16e-01
GO:BP	GO:0032413	negative regulation of ion transmembrane transporter activity	2	52	1.17e-01
GO:BP	GO:0048609	multicellular organismal reproductive process	2	538	1.17e-01
GO:BP	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	1	8	1.20e-01
GO:BP	GO:0070295	renal water absorption	1	6	1.20e-01
GO:BP	GO:0031397	negative regulation of protein ubiquitination	2	76	1.22e-01
GO:BP	GO:0051933	amino acid neurotransmitter reuptake	1	5	1.24e-01
GO:BP	GO:0070344	regulation of fat cell proliferation	1	8	1.24e-01
GO:BP	GO:0032504	multicellular organism reproduction	2	558	1.25e-01
GO:BP	GO:0006497	protein lipidation	1	89	1.25e-01
GO:BP	GO:0038003	G protein-coupled opioid receptor signaling pathway	1	5	1.25e-01
GO:BP	GO:0044458	motile cilium assembly	1	46	1.25e-01
GO:BP	GO:0031400	negative regulation of protein modification process	4	396	1.26e-01
GO:BP	GO:0050767	regulation of neurogenesis	3	302	1.26e-01
GO:BP	GO:0042158	lipoprotein biosynthetic process	1	92	1.26e-01
GO:BP	GO:0032410	negative regulation of transporter activity	2	59	1.26e-01
GO:BP	GO:0003006	developmental process involved in reproduction	2	603	1.26e-01
GO:BP	GO:0045664	regulation of neuron differentiation	1	137	1.26e-01
GO:BP	GO:1900125	regulation of hyaluronan biosynthetic process	1	6	1.26e-01
GO:BP	GO:0060449	bud elongation involved in lung branching	1	7	1.26e-01
GO:BP	GO:0002088	lens development in camera-type eye	2	57	1.27e-01
GO:BP	GO:0043951	negative regulation of cAMP-mediated signaling	1	10	1.33e-01
GO:BP	GO:0051382	kinetochore assembly	1	17	1.33e-01
GO:BP	GO:0042754	negative regulation of circadian rhythm	1	8	1.33e-01
GO:BP	GO:0050769	positive regulation of neurogenesis	1	190	1.33e-01
GO:BP	GO:0019953	sexual reproduction	2	633	1.33e-01
GO:BP	GO:1904063	negative regulation of cation transmembrane transport	2	64	1.33e-01
GO:BP	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	2	85	1.33e-01
GO:BP	GO:0032874	positive regulation of stress-activated MAPK cascade	2	95	1.33e-01
GO:BP	GO:0106070	regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	1	11	1.33e-01
GO:BP	GO:0006865	amino acid transport	2	103	1.33e-01
GO:BP	GO:1903321	negative regulation of protein modification by small protein conjugation or removal	2	86	1.33e-01
GO:BP	GO:0070304	positive regulation of stress-activated protein kinase signaling cascade	2	97	1.35e-01
GO:BP	GO:0006040	amino sugar metabolic process	1	34	1.36e-01
GO:BP	GO:0016202	regulation of striated muscle tissue development	1	13	1.36e-01
GO:BP	GO:0010885	regulation of cholesterol storage	1	13	1.36e-01
GO:BP	GO:0010717	regulation of epithelial to mesenchymal transition	2	87	1.36e-01
GO:BP	GO:1905039	carboxylic acid transmembrane transport	2	111	1.36e-01
GO:BP	GO:1903825	organic acid transmembrane transport	2	112	1.37e-01
GO:BP	GO:0003097	renal water transport	1	7	1.39e-01
GO:BP	GO:0045596	negative regulation of cell differentiation	5	471	1.39e-01
GO:BP	GO:0070341	fat cell proliferation	1	11	1.39e-01
GO:BP	GO:1901019	regulation of calcium ion transmembrane transporter activity	2	70	1.39e-01
GO:BP	GO:0045475	locomotor rhythm	1	13	1.39e-01
GO:BP	GO:0005976	polysaccharide metabolic process	2	81	1.39e-01
GO:BP	GO:0019935	cyclic-nucleotide-mediated signaling	2	52	1.39e-01
GO:BP	GO:0042157	lipoprotein metabolic process	1	116	1.40e-01
GO:BP	GO:0034766	negative regulation of monoatomic ion transmembrane transport	2	70	1.40e-01
GO:BP	GO:0051962	positive regulation of nervous system development	1	222	1.41e-01
GO:BP	GO:0051383	kinetochore organization	1	21	1.41e-01
GO:BP	GO:0000226	microtubule cytoskeleton organization	2	549	1.41e-01
GO:BP	GO:0046328	regulation of JNK cascade	2	113	1.41e-01
GO:BP	GO:0015711	organic anion transport	3	270	1.41e-01
GO:BP	GO:0045662	negative regulation of myoblast differentiation	1	20	1.41e-01
GO:BP	GO:0035082	axoneme assembly	1	54	1.41e-01
GO:BP	GO:0010958	regulation of amino acid import across plasma membrane	1	14	1.42e-01
GO:BP	GO:0051960	regulation of nervous system development	4	357	1.42e-01
GO:BP	GO:1903789	regulation of amino acid transmembrane transport	1	14	1.42e-01
GO:BP	GO:0018107	peptidyl-threonine phosphorylation	2	96	1.42e-01
GO:BP	GO:1901874	negative regulation of post-translational protein modification	2	98	1.45e-01
GO:BP	GO:0050435	amyloid-beta metabolic process	1	48	1.45e-01
GO:BP	GO:0010888	negative regulation of lipid storage	1	15	1.47e-01
GO:BP	GO:0098712	L-glutamate import across plasma membrane	1	11	1.47e-01
GO:BP	GO:0048634	regulation of muscle organ development	1	14	1.47e-01
GO:BP	GO:0034085	establishment of sister chromatid cohesion	1	10	1.49e-01
GO:BP	GO:0060349	bone morphogenesis	2	74	1.50e-01
GO:BP	GO:0048843	negative regulation of axon extension involved in axon guidance	1	26	1.50e-01
GO:BP	GO:0042063	gliogenesis	1	244	1.51e-01
GO:BP	GO:0050872	white fat cell differentiation	1	15	1.51e-01
GO:BP	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway	1	11	1.52e-01
GO:BP	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	1	8	1.52e-01
GO:BP	GO:0045595	regulation of cell differentiation	8	1122	1.52e-01
GO:BP	GO:0010878	cholesterol storage	1	18	1.52e-01
GO:BP	GO:0051580	regulation of neurotransmitter uptake	1	15	1.53e-01
GO:BP	GO:0018210	peptidyl-threonine modification	2	103	1.53e-01
GO:BP	GO:2000678	negative regulation of transcription regulatory region DNA binding	1	17	1.53e-01
GO:BP	GO:0051549	positive regulation of keratinocyte migration	1	11	1.53e-01
GO:BP	GO:0072348	sulfur compound transport	1	36	1.54e-01
GO:BP	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	1	33	1.57e-01
GO:BP	GO:0001933	negative regulation of protein phosphorylation	3	265	1.57e-01
GO:BP	GO:0006089	lactate metabolic process	1	16	1.57e-01
GO:BP	GO:0048511	rhythmic process	3	233	1.57e-01
GO:BP	GO:0001578	microtubule bundle formation	1	79	1.57e-01
GO:BP	GO:0070486	leukocyte aggregation	1	9	1.58e-01
GO:BP	GO:0030213	hyaluronan biosynthetic process	1	10	1.58e-01
GO:BP	GO:0036302	atrioventricular canal development	1	12	1.58e-01
GO:BP	GO:1901841	regulation of high voltage-gated calcium channel activity	1	12	1.62e-01
GO:BP	GO:0003014	renal system process	2	76	1.62e-01
GO:BP	GO:0015804	neutral amino acid transport	1	43	1.62e-01
GO:BP	GO:0048841	regulation of axon extension involved in axon guidance	1	31	1.62e-01
GO:BP	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus	1	10	1.62e-01
GO:BP	GO:0043543	protein acylation	1	193	1.62e-01
GO:BP	GO:0010838	positive regulation of keratinocyte proliferation	1	9	1.62e-01
GO:BP	GO:0097722	sperm motility	1	62	1.62e-01
GO:BP	GO:0034508	centromere complex assembly	1	29	1.62e-01
GO:BP	GO:0051547	regulation of keratinocyte migration	1	13	1.62e-01
GO:BP	GO:0030317	flagellated sperm motility	1	62	1.62e-01
GO:BP	GO:0043065	positive regulation of apoptotic process	4	394	1.63e-01
GO:BP	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	1	30	1.65e-01
GO:BP	GO:0007254	JNK cascade	2	137	1.65e-01
GO:BP	GO:0006836	neurotransmitter transport	2	141	1.65e-01
GO:BP	GO:0043620	regulation of DNA-templated transcription in response to stress	1	38	1.65e-01
GO:BP	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	1	13	1.65e-01
GO:BP	GO:0006487	protein N-linked glycosylation	1	65	1.65e-01
GO:BP	GO:0010720	positive regulation of cell development	1	318	1.65e-01
GO:BP	GO:0007623	circadian rhythm	2	160	1.65e-01
GO:BP	GO:0060294	cilium movement involved in cell motility	1	69	1.65e-01
GO:BP	GO:0001539	cilium or flagellum-dependent cell motility	1	72	1.66e-01
GO:BP	GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	1	14	1.66e-01
GO:BP	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	2	126	1.66e-01
GO:BP	GO:0043153	entrainment of circadian clock by photoperiod	1	23	1.66e-01
GO:BP	GO:0043068	positive regulation of programmed cell death	4	403	1.66e-01
GO:BP	GO:0048846	axon extension involved in axon guidance	1	35	1.66e-01
GO:BP	GO:0042326	negative regulation of phosphorylation	3	290	1.66e-01
GO:BP	GO:1902284	neuron projection extension involved in neuron projection guidance	1	35	1.66e-01
GO:BP	GO:0051177	meiotic sister chromatid cohesion	1	11	1.66e-01
GO:BP	GO:1901201	regulation of extracellular matrix assembly	1	15	1.66e-01
GO:BP	GO:0034763	negative regulation of transmembrane transport	2	96	1.66e-01
GO:BP	GO:0021591	ventricular system development	1	29	1.66e-01
GO:BP	GO:0022414	reproductive process	2	924	1.66e-01
GO:BP	GO:0055012	ventricular cardiac muscle cell differentiation	1	15	1.66e-01
GO:BP	GO:0043271	negative regulation of monoatomic ion transport	2	88	1.66e-01
GO:BP	GO:0060285	cilium-dependent cell motility	1	72	1.66e-01
GO:BP	GO:0000003	reproduction	2	933	1.66e-01
GO:BP	GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	2	127	1.68e-01
GO:BP	GO:0009648	photoperiodism	1	24	1.73e-01
GO:BP	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	1	16	1.73e-01
GO:BP	GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	2	122	1.73e-01
GO:BP	GO:0032872	regulation of stress-activated MAPK cascade	2	153	1.73e-01
GO:BP	GO:0001822	kidney development	3	246	1.74e-01
GO:BP	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	1	16	1.74e-01
GO:BP	GO:0070302	regulation of stress-activated protein kinase signaling cascade	2	157	1.78e-01
GO:BP	GO:0071526	semaphorin-plexin signaling pathway	1	44	1.78e-01
GO:BP	GO:0090181	regulation of cholesterol metabolic process	1	27	1.79e-01
GO:BP	GO:0009649	entrainment of circadian clock	1	27	1.79e-01
GO:BP	GO:0015813	L-glutamate transmembrane transport	1	18	1.79e-01
GO:BP	GO:0050919	negative chemotaxis	1	42	1.82e-01
GO:BP	GO:0030517	negative regulation of axon extension	1	41	1.82e-01
GO:BP	GO:0072001	renal system development	3	253	1.82e-01
GO:BP	GO:2001257	regulation of cation channel activity	2	100	1.83e-01
GO:BP	GO:0030856	regulation of epithelial cell differentiation	2	100	1.83e-01
GO:BP	GO:0060602	branch elongation of an epithelium	1	15	1.84e-01
GO:BP	GO:0007017	microtubule-based process	2	757	1.84e-01
GO:BP	GO:0051546	keratinocyte migration	1	15	1.86e-01
GO:BP	GO:0071498	cellular response to fluid shear stress	1	19	1.86e-01
GO:BP	GO:0043950	positive regulation of cAMP-mediated signaling	1	5	1.86e-01
GO:BP	GO:0003341	cilium movement	1	97	1.86e-01
GO:BP	GO:0010874	regulation of cholesterol efflux	1	31	1.86e-01
GO:BP	GO:0003417	growth plate cartilage development	1	14	1.88e-01
GO:BP	GO:0030010	establishment of cell polarity	2	135	1.88e-01
GO:BP	GO:0007286	spermatid development	1	108	1.88e-01
GO:BP	GO:0071174	mitotic spindle checkpoint signaling	1	43	1.91e-01
GO:BP	GO:0007094	mitotic spindle assembly checkpoint signaling	1	43	1.91e-01
GO:BP	GO:0036120	cellular response to platelet-derived growth factor stimulus	1	20	1.91e-01
GO:BP	GO:0071173	spindle assembly checkpoint signaling	1	43	1.91e-01
GO:BP	GO:0048515	spermatid differentiation	1	114	1.91e-01
GO:BP	GO:0099111	microtubule-based transport	1	192	1.92e-01
GO:BP	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	1	45	1.92e-01
GO:BP	GO:0009988	cell-cell recognition	1	31	1.92e-01
GO:BP	GO:1900746	regulation of vascular endothelial growth factor signaling pathway	1	18	1.92e-01
GO:BP	GO:0098810	neurotransmitter reuptake	1	21	1.92e-01
GO:BP	GO:0031577	spindle checkpoint signaling	1	44	1.92e-01
GO:BP	GO:1901861	regulation of muscle tissue development	1	34	1.92e-01
GO:BP	GO:0033046	negative regulation of sister chromatid segregation	1	45	1.92e-01
GO:BP	GO:0051180	vitamin transport	1	29	1.92e-01
GO:BP	GO:0042755	eating behavior	1	16	1.92e-01
GO:BP	GO:0033048	negative regulation of mitotic sister chromatid segregation	1	45	1.92e-01
GO:BP	GO:2000816	negative regulation of mitotic sister chromatid separation	1	45	1.92e-01
GO:BP	GO:0051301	cell division	1	569	1.93e-01
GO:BP	GO:0042177	negative regulation of protein catabolic process	1	100	1.93e-01
GO:BP	GO:0051938	L-glutamate import	1	24	1.94e-01
GO:BP	GO:1905819	negative regulation of chromosome separation	1	46	1.94e-01
GO:BP	GO:1902100	negative regulation of metaphase/anaphase transition of cell cycle	1	46	1.94e-01
GO:BP	GO:0051985	negative regulation of chromosome segregation	1	46	1.94e-01
GO:BP	GO:2000647	negative regulation of stem cell proliferation	1	18	1.94e-01
GO:BP	GO:0007517	muscle organ development	2	279	1.94e-01
GO:BP	GO:0036119	response to platelet-derived growth factor	1	22	1.94e-01
GO:BP	GO:0010563	negative regulation of phosphorus metabolic process	3	335	1.94e-01
GO:BP	GO:0021756	striatum development	1	18	1.94e-01
GO:BP	GO:0005996	monosaccharide metabolic process	2	212	1.94e-01
GO:BP	GO:0045936	negative regulation of phosphate metabolic process	3	334	1.94e-01
GO:BP	GO:0043409	negative regulation of MAPK cascade	2	145	1.94e-01
GO:BP	GO:0048011	neurotrophin TRK receptor signaling pathway	1	23	1.94e-01
GO:BP	GO:0001755	neural crest cell migration	1	49	1.94e-01
GO:BP	GO:1905953	negative regulation of lipid localization	1	31	1.94e-01
GO:BP	GO:0006612	protein targeting to membrane	1	120	1.94e-01
GO:BP	GO:1902547	regulation of cellular response to vascular endothelial growth factor stimulus	1	20	1.94e-01
GO:BP	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	2	71	1.94e-01
GO:BP	GO:0003091	renal water homeostasis	1	14	1.94e-01
GO:BP	GO:0043408	regulation of MAPK cascade	4	473	1.94e-01
GO:BP	GO:0090497	mesenchymal cell migration	1	51	1.95e-01
GO:BP	GO:0033047	regulation of mitotic sister chromatid segregation	1	51	1.97e-01
GO:BP	GO:0051783	regulation of nuclear division	2	115	1.97e-01
GO:BP	GO:0050922	negative regulation of chemotaxis	1	44	1.97e-01
GO:BP	GO:0035265	organ growth	2	128	1.98e-01
GO:BP	GO:0048512	circadian behavior	1	30	1.98e-01
GO:BP	GO:0051248	negative regulation of protein metabolic process	5	799	1.98e-01
GO:BP	GO:0051403	stress-activated MAPK cascade	2	188	1.99e-01
GO:BP	GO:0006767	water-soluble vitamin metabolic process	1	50	1.99e-01
GO:BP	GO:0045839	negative regulation of mitotic nuclear division	1	53	2.00e-01
GO:BP	GO:0010883	regulation of lipid storage	1	38	2.02e-01
GO:BP	GO:0007622	rhythmic behavior	1	32	2.03e-01
GO:BP	GO:0007130	synaptonemal complex assembly	1	10	2.03e-01
GO:BP	GO:0032331	negative regulation of chondrocyte differentiation	1	18	2.04e-01
GO:BP	GO:0050771	negative regulation of axonogenesis	1	59	2.05e-01
GO:BP	GO:0010965	regulation of mitotic sister chromatid separation	1	56	2.06e-01
GO:BP	GO:0045661	regulation of myoblast differentiation	1	60	2.06e-01
GO:BP	GO:0051955	regulation of amino acid transport	1	28	2.06e-01
GO:BP	GO:0031098	stress-activated protein kinase signaling cascade	2	194	2.06e-01
GO:BP	GO:0031345	negative regulation of cell projection organization	2	154	2.10e-01
GO:BP	GO:0034260	negative regulation of GTPase activity	1	25	2.10e-01
GO:BP	GO:0006833	water transport	1	12	2.11e-01
GO:BP	GO:0001504	neurotransmitter uptake	1	29	2.11e-01
GO:BP	GO:0009250	glucan biosynthetic process	1	40	2.11e-01
GO:BP	GO:0060441	epithelial tube branching involved in lung morphogenesis	1	21	2.11e-01
GO:BP	GO:0051784	negative regulation of nuclear division	1	56	2.11e-01
GO:BP	GO:0051306	mitotic sister chromatid separation	1	59	2.11e-01
GO:BP	GO:1901798	positive regulation of signal transduction by p53 class mediator	1	28	2.11e-01
GO:BP	GO:0005978	glycogen biosynthetic process	1	40	2.11e-01
GO:BP	GO:0060284	regulation of cell development	1	593	2.11e-01
GO:BP	GO:0045776	negative regulation of blood pressure	1	30	2.11e-01
GO:BP	GO:0051093	negative regulation of developmental process	5	654	2.11e-01
GO:BP	GO:0045597	positive regulation of cell differentiation	1	618	2.11e-01
GO:BP	GO:0044092	negative regulation of molecular function	5	730	2.12e-01
GO:BP	GO:0003416	endochondral bone growth	1	22	2.12e-01
GO:BP	GO:1903169	regulation of calcium ion transmembrane transport	2	120	2.12e-01
GO:BP	GO:0033344	cholesterol efflux	1	41	2.12e-01
GO:BP	GO:0070193	synaptonemal complex organization	1	13	2.12e-01
GO:BP	GO:0021544	subpallium development	1	19	2.12e-01
GO:BP	GO:0003401	axis elongation	1	25	2.12e-01
GO:BP	GO:0035116	embryonic hindlimb morphogenesis	1	17	2.12e-01
GO:BP	GO:0090162	establishment of epithelial cell polarity	1	30	2.13e-01
GO:BP	GO:0050890	cognition	2	226	2.13e-01
GO:BP	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	1	36	2.14e-01
GO:BP	GO:0070293	renal absorption	1	24	2.15e-01
GO:BP	GO:0043392	negative regulation of DNA binding	1	44	2.15e-01
GO:BP	GO:0006469	negative regulation of protein kinase activity	2	173	2.15e-01
GO:BP	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	1	25	2.15e-01
GO:BP	GO:0046323	glucose import	1	55	2.18e-01
GO:BP	GO:0001654	eye development	3	273	2.19e-01
GO:BP	GO:0061037	negative regulation of cartilage development	1	23	2.20e-01
GO:BP	GO:0060317	cardiac epithelial to mesenchymal transition	1	28	2.20e-01
GO:BP	GO:0030212	hyaluronan metabolic process	1	21	2.20e-01
GO:BP	GO:0007179	transforming growth factor beta receptor signaling pathway	2	177	2.20e-01
GO:BP	GO:0014032	neural crest cell development	1	70	2.20e-01
GO:BP	GO:0150063	visual system development	3	274	2.20e-01
GO:BP	GO:0032371	regulation of sterol transport	1	45	2.20e-01
GO:BP	GO:0032374	regulation of cholesterol transport	1	45	2.20e-01
GO:BP	GO:2000677	regulation of transcription regulatory region DNA binding	1	43	2.20e-01
GO:BP	GO:0050891	multicellular organismal-level water homeostasis	1	17	2.20e-01
GO:BP	GO:0098868	bone growth	1	23	2.20e-01
GO:BP	GO:0048880	sensory system development	3	276	2.24e-01
GO:BP	GO:0090150	establishment of protein localization to membrane	1	258	2.24e-01
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	1	744	2.24e-01
GO:BP	GO:0034405	response to fluid shear stress	1	31	2.24e-01
GO:BP	GO:1905818	regulation of chromosome separation	1	69	2.24e-01
GO:BP	GO:0048864	stem cell development	1	75	2.29e-01
GO:BP	GO:0048384	retinoic acid receptor signaling pathway	1	27	2.29e-01
GO:BP	GO:0048566	embryonic digestive tract development	1	20	2.29e-01
GO:BP	GO:0000132	establishment of mitotic spindle orientation	1	32	2.32e-01
GO:BP	GO:0032885	regulation of polysaccharide biosynthetic process	1	32	2.32e-01
GO:BP	GO:0031396	regulation of protein ubiquitination	2	194	2.32e-01
GO:BP	GO:0060351	cartilage development involved in endochondral bone morphogenesis	1	25	2.33e-01
GO:BP	GO:0016051	carbohydrate biosynthetic process	2	160	2.33e-01
GO:BP	GO:0000165	MAPK cascade	4	553	2.34e-01
GO:BP	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	1	36	2.35e-01
GO:BP	GO:0006605	protein targeting	1	310	2.36e-01
GO:BP	GO:0038179	neurotrophin signaling pathway	1	36	2.36e-01
GO:BP	GO:0002931	response to ischemia	1	48	2.36e-01
GO:BP	GO:0060271	cilium assembly	1	296	2.36e-01
GO:BP	GO:0042044	fluid transport	1	19	2.36e-01
GO:BP	GO:0014033	neural crest cell differentiation	1	79	2.36e-01
GO:BP	GO:0051304	chromosome separation	1	75	2.36e-01
GO:BP	GO:0048048	embryonic eye morphogenesis	1	25	2.36e-01
GO:BP	GO:0030516	regulation of axon extension	1	82	2.36e-01
GO:BP	GO:0007267	cell-cell signaling	5	1150	2.36e-01
GO:BP	GO:0033673	negative regulation of kinase activity	2	191	2.36e-01
GO:BP	GO:0043410	positive regulation of MAPK cascade	3	316	2.36e-01
GO:BP	GO:0002068	glandular epithelial cell development	1	28	2.36e-01
GO:BP	GO:0035137	hindlimb morphogenesis	1	21	2.36e-01
GO:BP	GO:0040020	regulation of meiotic nuclear division	1	19	2.36e-01
GO:BP	GO:0003008	system process	6	1194	2.38e-01
GO:BP	GO:0014911	positive regulation of smooth muscle cell migration	1	32	2.38e-01
GO:BP	GO:0046942	carboxylic acid transport	2	213	2.39e-01
GO:BP	GO:0140013	meiotic nuclear division	2	117	2.39e-01
GO:BP	GO:0098916	anterograde trans-synaptic signaling	2	490	2.39e-01
GO:BP	GO:0007268	chemical synaptic transmission	2	490	2.39e-01
GO:BP	GO:0015849	organic acid transport	2	214	2.39e-01
GO:BP	GO:0019229	regulation of vasoconstriction	1	38	2.40e-01
GO:BP	GO:0099537	trans-synaptic signaling	2	494	2.41e-01
GO:BP	GO:0045445	myoblast differentiation	1	90	2.43e-01
GO:BP	GO:0044782	cilium organization	1	317	2.43e-01
GO:BP	GO:0007163	establishment or maintenance of cell polarity	2	197	2.43e-01
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	9	1832	2.45e-01
GO:BP	GO:0032881	regulation of polysaccharide metabolic process	1	35	2.45e-01
GO:BP	GO:0085029	extracellular matrix assembly	1	36	2.45e-01
GO:BP	GO:0038084	vascular endothelial growth factor signaling pathway	1	35	2.45e-01
GO:BP	GO:0040001	establishment of mitotic spindle localization	1	37	2.45e-01
GO:BP	GO:0030071	regulation of mitotic metaphase/anaphase transition	1	87	2.45e-01
GO:BP	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	1	37	2.45e-01
GO:BP	GO:0090311	regulation of protein deacetylation	1	44	2.46e-01
GO:BP	GO:0035725	sodium ion transmembrane transport	1	112	2.46e-01
GO:BP	GO:0051294	establishment of spindle orientation	1	37	2.46e-01
GO:BP	GO:0099536	synaptic signaling	2	512	2.46e-01
GO:BP	GO:0007018	microtubule-based movement	1	300	2.46e-01
GO:BP	GO:0007010	cytoskeleton organization	2	1186	2.48e-01
GO:BP	GO:0051310	metaphase chromosome alignment	1	87	2.48e-01
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	1	918	2.48e-01
GO:BP	GO:1902099	regulation of metaphase/anaphase transition of cell cycle	1	88	2.48e-01
GO:BP	GO:1902475	L-alpha-amino acid transmembrane transport	1	51	2.48e-01
GO:BP	GO:0048640	negative regulation of developmental growth	1	94	2.48e-01
GO:BP	GO:0008284	positive regulation of cell population proliferation	1	886	2.48e-01
GO:BP	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	1	91	2.48e-01
GO:BP	GO:0060348	bone development	2	157	2.48e-01
GO:BP	GO:0050793	regulation of developmental process	5	1813	2.48e-01
GO:BP	GO:0061387	regulation of extent of cell growth	1	96	2.48e-01
GO:BP	GO:2001251	negative regulation of chromosome organization	1	89	2.48e-01
GO:BP	GO:0032922	circadian regulation of gene expression	1	63	2.48e-01
GO:BP	GO:0050795	regulation of behavior	1	41	2.50e-01
GO:BP	GO:0010837	regulation of keratinocyte proliferation	1	33	2.50e-01
GO:BP	GO:0044784	metaphase/anaphase transition of cell cycle	1	92	2.51e-01
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	1	1005	2.52e-01
GO:BP	GO:0051094	positive regulation of developmental process	1	957	2.52e-01
GO:BP	GO:0006486	protein glycosylation	1	185	2.52e-01
GO:BP	GO:0043413	macromolecule glycosylation	1	185	2.52e-01
GO:BP	GO:0060560	developmental growth involved in morphogenesis	2	207	2.52e-01
GO:BP	GO:0046580	negative regulation of Ras protein signal transduction	1	46	2.53e-01
GO:BP	GO:0042632	cholesterol homeostasis	1	58	2.53e-01
GO:BP	GO:0044042	glucan metabolic process	1	65	2.53e-01
GO:BP	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	1	37	2.53e-01
GO:BP	GO:0007264	small GTPase mediated signal transduction	3	413	2.53e-01
GO:BP	GO:0008037	cell recognition	1	82	2.53e-01
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	2	211	2.53e-01
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	5	707	2.53e-01
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	1	1014	2.53e-01
GO:BP	GO:0055092	sterol homeostasis	1	59	2.53e-01
GO:BP	GO:0005977	glycogen metabolic process	1	64	2.53e-01
GO:BP	GO:1903046	meiotic cell cycle process	2	132	2.53e-01
GO:BP	GO:0019915	lipid storage	1	68	2.53e-01
GO:BP	GO:0019233	sensory perception of pain	1	39	2.53e-01
GO:BP	GO:0051726	regulation of cell cycle	4	941	2.53e-01
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	3	445	2.53e-01
GO:BP	GO:0031641	regulation of myelination	1	35	2.53e-01
GO:BP	GO:1903320	regulation of protein modification by small protein conjugation or removal	2	232	2.53e-01
GO:BP	GO:0010389	regulation of G2/M transition of mitotic cell cycle	1	94	2.53e-01
GO:BP	GO:0006766	vitamin metabolic process	1	75	2.53e-01
GO:BP	GO:0000280	nuclear division	3	343	2.53e-01
GO:BP	GO:0033045	regulation of sister chromatid segregation	1	99	2.53e-01
GO:BP	GO:2000026	regulation of multicellular organismal development	1	997	2.53e-01
GO:BP	GO:0070085	glycosylation	1	197	2.53e-01
GO:BP	GO:1904659	glucose transmembrane transport	1	84	2.53e-01
GO:BP	GO:0032890	regulation of organic acid transport	1	48	2.53e-01
GO:BP	GO:0030182	neuron differentiation	1	1058	2.53e-01
GO:BP	GO:0051303	establishment of chromosome localization	1	93	2.54e-01
GO:BP	GO:0048705	skeletal system morphogenesis	2	155	2.54e-01
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	2	222	2.54e-01
GO:BP	GO:0051348	negative regulation of transferase activity	2	225	2.54e-01
GO:BP	GO:0051253	negative regulation of RNA metabolic process	1	1112	2.54e-01
GO:BP	GO:0008645	hexose transmembrane transport	1	87	2.54e-01
GO:BP	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	1	102	2.54e-01
GO:BP	GO:0019218	regulation of steroid metabolic process	1	68	2.54e-01
GO:BP	GO:0009101	glycoprotein biosynthetic process	2	251	2.54e-01
GO:BP	GO:0048675	axon extension	1	108	2.54e-01
GO:BP	GO:0060425	lung morphogenesis	1	39	2.57e-01
GO:BP	GO:0048468	cell development	2	1950	2.57e-01
GO:BP	GO:0015749	monosaccharide transmembrane transport	1	88	2.57e-01
GO:BP	GO:0008306	associative learning	1	65	2.57e-01
GO:BP	GO:0071559	response to transforming growth factor beta	2	227	2.58e-01
GO:BP	GO:0042310	vasoconstriction	1	51	2.58e-01
GO:BP	GO:0048699	generation of neurons	1	1120	2.59e-01
GO:BP	GO:1902749	regulation of cell cycle G2/M phase transition	1	105	2.61e-01
GO:BP	GO:0071702	organic substance transport	7	2133	2.61e-01
GO:BP	GO:0050000	chromosome localization	1	101	2.62e-01
GO:BP	GO:0014706	striated muscle tissue development	2	214	2.63e-01
GO:BP	GO:0030335	positive regulation of cell migration	3	408	2.63e-01
GO:BP	GO:0015807	L-amino acid transport	1	62	2.63e-01
GO:BP	GO:0002066	columnar/cuboidal epithelial cell development	1	39	2.65e-01
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	1	1203	2.66e-01
GO:BP	GO:0051058	negative regulation of small GTPase mediated signal transduction	1	52	2.66e-01
GO:BP	GO:0006094	gluconeogenesis	1	70	2.66e-01
GO:BP	GO:0006112	energy reserve metabolic process	1	72	2.66e-01
GO:BP	GO:0007088	regulation of mitotic nuclear division	1	99	2.66e-01
GO:BP	GO:0051924	regulation of calcium ion transport	2	167	2.66e-01
GO:BP	GO:0010977	negative regulation of neuron projection development	1	117	2.69e-01
GO:BP	GO:0043407	negative regulation of MAP kinase activity	1	50	2.69e-01
GO:BP	GO:0032330	regulation of chondrocyte differentiation	1	36	2.69e-01
GO:BP	GO:0034219	carbohydrate transmembrane transport	1	95	2.69e-01
GO:BP	GO:0072657	protein localization to membrane	1	530	2.69e-01
GO:BP	GO:1903053	regulation of extracellular matrix organization	1	47	2.70e-01
GO:BP	GO:0019319	hexose biosynthetic process	1	73	2.70e-01
GO:BP	GO:0043616	keratinocyte proliferation	1	39	2.70e-01
GO:BP	GO:0051240	positive regulation of multicellular organismal process	1	1103	2.72e-01
GO:BP	GO:0006814	sodium ion transport	1	158	2.73e-01
GO:BP	GO:0051293	establishment of spindle localization	1	49	2.73e-01
GO:BP	GO:0030301	cholesterol transport	1	81	2.73e-01
GO:BP	GO:0033554	cellular response to stress	7	1662	2.73e-01
GO:BP	GO:0120031	plasma membrane bounded cell projection assembly	1	463	2.73e-01
GO:BP	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	2	189	2.73e-01
GO:BP	GO:0006835	dicarboxylic acid transport	1	61	2.73e-01
GO:BP	GO:0050768	negative regulation of neurogenesis	1	113	2.73e-01
GO:BP	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	2	113	2.74e-01
GO:BP	GO:0007129	homologous chromosome pairing at meiosis	1	24	2.74e-01
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	1	1298	2.76e-01
GO:BP	GO:0022008	neurogenesis	1	1297	2.76e-01
GO:BP	GO:0051983	regulation of chromosome segregation	1	121	2.76e-01
GO:BP	GO:0007416	synapse assembly	1	153	2.76e-01
GO:BP	GO:0030031	cell projection assembly	1	473	2.76e-01
GO:BP	GO:0051588	regulation of neurotransmitter transport	1	71	2.76e-01
GO:BP	GO:1900024	regulation of substrate adhesion-dependent cell spreading	1	54	2.76e-01
GO:BP	GO:2000147	positive regulation of cell motility	3	421	2.76e-01
GO:BP	GO:0035924	cellular response to vascular endothelial growth factor stimulus	1	54	2.76e-01
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	1	1305	2.76e-01
GO:BP	GO:0051952	regulation of amine transport	1	56	2.77e-01
GO:BP	GO:0051961	negative regulation of nervous system development	1	119	2.78e-01
GO:BP	GO:0048285	organelle fission	3	387	2.78e-01
GO:BP	GO:0005975	carbohydrate metabolic process	3	439	2.80e-01
GO:BP	GO:0051668	localization within membrane	1	611	2.80e-01
GO:BP	GO:0051653	spindle localization	1	53	2.80e-01
GO:BP	GO:0050770	regulation of axonogenesis	1	139	2.80e-01
GO:BP	GO:0046364	monosaccharide biosynthetic process	1	82	2.80e-01
GO:BP	GO:0022898	regulation of transmembrane transporter activity	2	200	2.80e-01
GO:BP	GO:0007062	sister chromatid cohesion	1	52	2.80e-01
GO:BP	GO:0007631	feeding behavior	1	51	2.80e-01
GO:BP	GO:0040017	positive regulation of locomotion	3	429	2.82e-01
GO:BP	GO:0070372	regulation of ERK1 and ERK2 cascade	2	192	2.82e-01
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	2	249	2.83e-01
GO:BP	GO:0000086	G2/M transition of mitotic cell cycle	1	130	2.83e-01
GO:BP	GO:0060350	endochondral bone morphogenesis	1	47	2.84e-01
GO:BP	GO:0051254	positive regulation of RNA metabolic process	1	1425	2.86e-01
GO:BP	GO:0007218	neuropeptide signaling pathway	1	36	2.86e-01
GO:BP	GO:0015918	sterol transport	1	93	2.86e-01
GO:BP	GO:0014910	regulation of smooth muscle cell migration	1	57	2.86e-01
GO:BP	GO:1902531	regulation of intracellular signal transduction	7	1318	2.87e-01
GO:BP	GO:0007093	mitotic cell cycle checkpoint signaling	1	137	2.87e-01
GO:BP	GO:0008643	carbohydrate transport	1	114	2.88e-01
GO:BP	GO:0098657	import into cell	3	664	2.92e-01
GO:BP	GO:0015837	amine transport	1	59	2.92e-01
GO:BP	GO:0032355	response to estradiol	1	79	2.92e-01
GO:BP	GO:0080135	regulation of cellular response to stress	3	585	2.92e-01
GO:BP	GO:0008283	cell population proliferation	2	2340	2.94e-01
GO:BP	GO:0009895	negative regulation of catabolic process	1	287	2.94e-01
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	2	261	2.94e-01
GO:BP	GO:0008285	negative regulation of cell population proliferation	4	643	2.97e-01
GO:BP	GO:0030330	DNA damage response, signal transduction by p53 class mediator	1	70	2.97e-01
GO:BP	GO:0032409	regulation of transporter activity	2	212	2.97e-01
GO:BP	GO:0030334	regulation of cell migration	4	707	2.98e-01
GO:BP	GO:0006024	glycosaminoglycan biosynthetic process	1	59	2.98e-01
GO:BP	GO:0090596	sensory organ morphogenesis	2	179	2.98e-01
GO:BP	GO:0051480	regulation of cytosolic calcium ion concentration	1	39	2.98e-01
GO:BP	GO:0032368	regulation of lipid transport	1	91	2.98e-01
GO:BP	GO:0045143	homologous chromosome segregation	1	32	2.98e-01
GO:BP	GO:0044839	cell cycle G2/M phase transition	1	145	2.99e-01
GO:BP	GO:0008203	cholesterol metabolic process	1	99	2.99e-01
GO:BP	GO:0070192	chromosome organization involved in meiotic cell cycle	1	35	3.00e-01
GO:BP	GO:0061061	muscle structure development	2	552	3.00e-01
GO:BP	GO:0006023	aminoglycan biosynthetic process	1	61	3.00e-01
GO:BP	GO:0070371	ERK1 and ERK2 cascade	2	211	3.00e-01
GO:BP	GO:1990138	neuron projection extension	1	149	3.00e-01
GO:BP	GO:0014909	smooth muscle cell migration	1	64	3.00e-01
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	1	1589	3.00e-01
GO:BP	GO:0042176	regulation of protein catabolic process	1	328	3.00e-01
GO:BP	GO:0034762	regulation of transmembrane transport	3	392	3.00e-01
GO:BP	GO:0009100	glycoprotein metabolic process	2	315	3.01e-01
GO:BP	GO:0140962	multicellular organismal-level chemical homeostasis	1	48	3.01e-01
GO:BP	GO:0051445	regulation of meiotic cell cycle	1	45	3.02e-01
GO:BP	GO:0018193	peptidyl-amino acid modification	1	866	3.02e-01
GO:BP	GO:1901873	regulation of post-translational protein modification	2	302	3.04e-01
GO:BP	GO:0006476	protein deacetylation	1	81	3.04e-01
GO:BP	GO:0048562	embryonic organ morphogenesis	2	186	3.04e-01
GO:BP	GO:0006886	intracellular protein transport	1	803	3.04e-01
GO:BP	GO:0048871	multicellular organismal-level homeostasis	4	570	3.04e-01
GO:BP	GO:1902652	secondary alcohol metabolic process	1	106	3.04e-01
GO:BP	GO:0030308	negative regulation of cell growth	1	161	3.04e-01
GO:BP	GO:0008361	regulation of cell size	1	160	3.04e-01
GO:BP	GO:0008543	fibroblast growth factor receptor signaling pathway	1	59	3.04e-01
GO:BP	GO:0051101	regulation of DNA binding	1	102	3.04e-01
GO:BP	GO:0061035	regulation of cartilage development	1	53	3.04e-01
GO:BP	GO:0045913	positive regulation of carbohydrate metabolic process	1	61	3.04e-01
GO:BP	GO:0007015	actin filament organization	1	372	3.04e-01
GO:BP	GO:0008015	blood circulation	2	372	3.04e-01
GO:BP	GO:0090066	regulation of anatomical structure size	2	395	3.04e-01
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	1	114	3.04e-01
GO:BP	GO:0042127	regulation of cell population proliferation	1	1568	3.09e-01
GO:BP	GO:0002067	glandular epithelial cell differentiation	1	49	3.09e-01
GO:BP	GO:0051321	meiotic cell cycle	2	183	3.11e-01
GO:BP	GO:0048870	cell motility	2	1169	3.12e-01
GO:BP	GO:0016125	sterol metabolic process	1	108	3.12e-01
GO:BP	GO:0051129	negative regulation of cellular component organization	2	592	3.13e-01
GO:BP	GO:0008277	regulation of G protein-coupled receptor signaling pathway	1	93	3.14e-01
GO:BP	GO:0001570	vasculogenesis	1	67	3.22e-01
GO:BP	GO:0007423	sensory organ development	3	395	3.22e-01
GO:BP	GO:1901991	negative regulation of mitotic cell cycle phase transition	1	165	3.22e-01
GO:BP	GO:0019932	second-messenger-mediated signaling	2	182	3.23e-01
GO:BP	GO:2000145	regulation of cell motility	4	741	3.23e-01
GO:BP	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	1	165	3.23e-01
GO:BP	GO:0055085	transmembrane transport	4	1014	3.23e-01
GO:BP	GO:0043010	camera-type eye development	2	237	3.23e-01
GO:BP	GO:0055088	lipid homeostasis	1	116	3.25e-01
GO:BP	GO:1905952	regulation of lipid localization	1	110	3.25e-01
GO:BP	GO:0014812	muscle cell migration	1	75	3.25e-01
GO:BP	GO:0098813	nuclear chromosome segregation	2	264	3.28e-01
GO:BP	GO:0035601	protein deacylation	1	91	3.28e-01
GO:BP	GO:0000070	mitotic sister chromatid segregation	1	178	3.28e-01
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	2	232	3.28e-01
GO:BP	GO:0007049	cell cycle	7	1515	3.29e-01
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	1	1764	3.29e-01
GO:BP	GO:0098732	macromolecule deacylation	1	92	3.29e-01
GO:BP	GO:1901137	carbohydrate derivative biosynthetic process	3	544	3.29e-01
GO:BP	GO:0043087	regulation of GTPase activity	2	288	3.31e-01
GO:BP	GO:0097746	blood vessel diameter maintenance	1	98	3.33e-01
GO:BP	GO:0035296	regulation of tube diameter	1	98	3.33e-01
GO:BP	GO:0050920	regulation of chemotaxis	1	143	3.33e-01
GO:BP	GO:0000075	cell cycle checkpoint signaling	1	184	3.33e-01
GO:BP	GO:0035150	regulation of tube size	1	98	3.34e-01
GO:BP	GO:0006366	transcription by RNA polymerase II	1	1852	3.36e-01
GO:BP	GO:1901615	organic hydroxy compound metabolic process	2	375	3.36e-01
GO:BP	GO:0071897	DNA biosynthetic process	1	174	3.36e-01
GO:BP	GO:1901566	organonitrogen compound biosynthetic process	2	1496	3.36e-01
GO:BP	GO:0048869	cellular developmental process	13	2943	3.36e-01
GO:BP	GO:0007399	nervous system development	1	1886	3.36e-01
GO:BP	GO:0030154	cell differentiation	13	2942	3.36e-01
GO:BP	GO:0007612	learning	1	114	3.36e-01
GO:BP	GO:0048588	developmental cell growth	1	194	3.37e-01
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	2	298	3.38e-01
GO:BP	GO:0071363	cellular response to growth factor stimulus	3	549	3.38e-01
GO:BP	GO:0072091	regulation of stem cell proliferation	1	58	3.38e-01
GO:BP	GO:0040012	regulation of locomotion	4	762	3.39e-01
GO:BP	GO:0007411	axon guidance	1	177	3.43e-01
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	1	1896	3.43e-01
GO:BP	GO:0097485	neuron projection guidance	1	177	3.43e-01
GO:BP	GO:1903510	mucopolysaccharide metabolic process	1	75	3.43e-01
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	1	140	3.43e-01
GO:BP	GO:0050878	regulation of body fluid levels	2	237	3.43e-01
GO:BP	GO:0045132	meiotic chromosome segregation	1	51	3.43e-01
GO:BP	GO:1903829	positive regulation of protein localization	1	392	3.44e-01
GO:BP	GO:0016525	negative regulation of angiogenesis	1	71	3.44e-01
GO:BP	GO:0070588	calcium ion transmembrane transport	2	221	3.44e-01
GO:BP	GO:1901796	regulation of signal transduction by p53 class mediator	1	102	3.45e-01
GO:BP	GO:0048589	developmental growth	3	522	3.46e-01
GO:BP	GO:0009891	positive regulation of biosynthetic process	1	1972	3.46e-01
GO:BP	GO:0048863	stem cell differentiation	1	196	3.46e-01
GO:BP	GO:0090288	negative regulation of cellular response to growth factor stimulus	1	80	3.46e-01
GO:BP	GO:0043255	regulation of carbohydrate biosynthetic process	1	79	3.46e-01
GO:BP	GO:0070887	cellular response to chemical stimulus	1	1857	3.46e-01
GO:BP	GO:0045926	negative regulation of growth	1	204	3.46e-01
GO:BP	GO:2000181	negative regulation of blood vessel morphogenesis	1	72	3.46e-01
GO:BP	GO:1901343	negative regulation of vasculature development	1	72	3.46e-01
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	1	1958	3.46e-01
GO:BP	GO:0034446	substrate adhesion-dependent cell spreading	1	90	3.46e-01
GO:BP	GO:0070925	organelle assembly	1	828	3.46e-01
GO:BP	GO:1990830	cellular response to leukemia inhibitory factor	1	86	3.46e-01
GO:BP	GO:0051100	negative regulation of binding	1	133	3.46e-01
GO:BP	GO:1990823	response to leukemia inhibitory factor	1	87	3.48e-01
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	1	1669	3.48e-01
GO:BP	GO:0033138	positive regulation of peptidyl-serine phosphorylation	1	68	3.52e-01
GO:BP	GO:0070848	response to growth factor	3	571	3.52e-01
GO:BP	GO:0044344	cellular response to fibroblast growth factor stimulus	1	81	3.52e-01
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	1	1708	3.52e-01
GO:BP	GO:0042472	inner ear morphogenesis	1	59	3.53e-01
GO:BP	GO:0071901	negative regulation of protein serine/threonine kinase activity	1	96	3.53e-01
GO:BP	GO:0009890	negative regulation of biosynthetic process	1	1721	3.53e-01
GO:BP	GO:0071347	cellular response to interleukin-1	1	64	3.57e-01
GO:BP	GO:0001657	ureteric bud development	1	75	3.58e-01
GO:BP	GO:0045930	negative regulation of mitotic cell cycle	1	209	3.58e-01
GO:BP	GO:0000819	sister chromatid segregation	1	217	3.59e-01
GO:BP	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	1	78	3.59e-01
GO:BP	GO:0072163	mesonephric epithelium development	1	76	3.59e-01
GO:BP	GO:0072164	mesonephric tubule development	1	76	3.59e-01
GO:BP	GO:0050796	regulation of insulin secretion	1	119	3.61e-01
GO:BP	GO:0035556	intracellular signal transduction	9	2036	3.65e-01
GO:BP	GO:0010721	negative regulation of cell development	1	190	3.66e-01
GO:BP	GO:0008217	regulation of blood pressure	1	114	3.66e-01
GO:BP	GO:0051239	regulation of multicellular organismal process	1	2052	3.66e-01
GO:BP	GO:0071774	response to fibroblast growth factor	1	85	3.66e-01
GO:BP	GO:0065004	protein-DNA complex assembly	1	171	3.67e-01
GO:BP	GO:0001823	mesonephros development	1	77	3.67e-01
GO:BP	GO:0030036	actin cytoskeleton organization	1	566	3.76e-01
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	1	2367	3.76e-01
GO:BP	GO:0030203	glycosaminoglycan metabolic process	1	87	3.77e-01
GO:BP	GO:0050804	modulation of chemical synaptic transmission	1	343	3.79e-01
GO:BP	GO:0099177	regulation of trans-synaptic signaling	1	344	3.79e-01
GO:BP	GO:0001505	regulation of neurotransmitter levels	1	132	3.80e-01
GO:BP	GO:0033044	regulation of chromosome organization	1	235	3.80e-01
GO:BP	GO:0010959	regulation of metal ion transport	2	271	3.82e-01
GO:BP	GO:0006006	glucose metabolic process	1	153	3.84e-01
GO:BP	GO:1901988	negative regulation of cell cycle phase transition	1	234	3.86e-01
GO:BP	GO:0016567	protein ubiquitination	3	684	3.90e-01
GO:BP	GO:0031324	negative regulation of cellular metabolic process	1	2069	3.91e-01
GO:BP	GO:0055007	cardiac muscle cell differentiation	1	108	3.91e-01
GO:BP	GO:0010811	positive regulation of cell-substrate adhesion	1	99	3.94e-01
GO:BP	GO:0002062	chondrocyte differentiation	1	89	3.94e-01
GO:BP	GO:0030855	epithelial cell differentiation	3	439	3.94e-01
GO:BP	GO:0042471	ear morphogenesis	1	73	3.94e-01
GO:BP	GO:0006022	aminoglycan metabolic process	1	92	3.95e-01
GO:BP	GO:0006936	muscle contraction	1	266	3.95e-01
GO:BP	GO:0001667	ameboidal-type cell migration	2	358	3.97e-01
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	1	2131	3.97e-01
GO:BP	GO:0007626	locomotory behavior	1	139	3.97e-01
GO:BP	GO:0072089	stem cell proliferation	1	84	3.97e-01
GO:BP	GO:0048638	regulation of developmental growth	1	254	3.99e-01
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	1	80	3.99e-01
GO:BP	GO:0090276	regulation of peptide hormone secretion	1	135	3.99e-01
GO:BP	GO:0015031	protein transport	1	1366	4.00e-01
GO:BP	GO:0046907	intracellular transport	1	1440	4.00e-01
GO:BP	GO:0030073	insulin secretion	1	144	4.01e-01
GO:BP	GO:0030029	actin filament-based process	1	643	4.01e-01
GO:BP	GO:0002791	regulation of peptide secretion	1	137	4.01e-01
GO:BP	GO:0031325	positive regulation of cellular metabolic process	1	2518	4.01e-01
GO:BP	GO:0140014	mitotic nuclear division	1	251	4.01e-01
GO:BP	GO:0030326	embryonic limb morphogenesis	1	89	4.01e-01
GO:BP	GO:0035113	embryonic appendage morphogenesis	1	89	4.01e-01
GO:BP	GO:0090087	regulation of peptide transport	1	139	4.01e-01
GO:BP	GO:0006355	regulation of DNA-templated transcription	1	2560	4.01e-01
GO:BP	GO:0034502	protein localization to chromosome	1	101	4.02e-01
GO:BP	GO:0070555	response to interleukin-1	1	82	4.02e-01
GO:BP	GO:0060537	muscle tissue development	2	347	4.02e-01
GO:BP	GO:2001141	regulation of RNA biosynthetic process	1	2577	4.02e-01
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	1	2607	4.04e-01
GO:BP	GO:0051051	negative regulation of transport	2	317	4.05e-01
GO:BP	GO:0051241	negative regulation of multicellular organismal process	4	744	4.05e-01
GO:BP	GO:0033135	regulation of peptidyl-serine phosphorylation	1	97	4.05e-01
GO:BP	GO:0042981	regulation of apoptotic process	5	1092	4.05e-01
GO:BP	GO:0040013	negative regulation of locomotion	1	262	4.05e-01
GO:BP	GO:0034329	cell junction assembly	1	347	4.06e-01
GO:BP	GO:0072330	monocarboxylic acid biosynthetic process	1	146	4.07e-01
GO:BP	GO:0043547	positive regulation of GTPase activity	1	211	4.07e-01
GO:BP	GO:0097435	supramolecular fiber organization	1	666	4.07e-01
GO:BP	GO:0009892	negative regulation of metabolic process	1	2297	4.07e-01
GO:BP	GO:0006351	DNA-templated transcription	1	2669	4.07e-01
GO:BP	GO:0045184	establishment of protein localization	1	1468	4.08e-01
GO:BP	GO:0051656	establishment of organelle localization	2	397	4.08e-01
GO:BP	GO:0032774	RNA biosynthetic process	1	2699	4.10e-01
GO:BP	GO:0007059	chromosome segregation	2	360	4.10e-01
GO:BP	GO:0048585	negative regulation of response to stimulus	5	1267	4.12e-01
GO:BP	GO:0010948	negative regulation of cell cycle process	1	271	4.12e-01
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	1	214	4.15e-01
GO:BP	GO:0007127	meiosis I	1	73	4.15e-01
GO:BP	GO:0006816	calcium ion transport	2	275	4.18e-01
GO:BP	GO:0048565	digestive tract development	1	92	4.19e-01
GO:BP	GO:0051252	regulation of RNA metabolic process	1	2824	4.22e-01
GO:BP	GO:0006810	transport	2	3294	4.24e-01
GO:BP	GO:0019318	hexose metabolic process	1	187	4.24e-01
GO:BP	GO:0050808	synapse organization	1	373	4.24e-01
GO:BP	GO:0043067	regulation of programmed cell death	5	1124	4.24e-01
GO:BP	GO:0009893	positive regulation of metabolic process	1	2846	4.25e-01
GO:BP	GO:0061982	meiosis I cell cycle process	1	77	4.26e-01
GO:BP	GO:0010634	positive regulation of epithelial cell migration	1	132	4.27e-01
GO:BP	GO:0045444	fat cell differentiation	1	187	4.27e-01
GO:BP	GO:0032535	regulation of cellular component size	1	306	4.27e-01
GO:BP	GO:0009968	negative regulation of signal transduction	4	1017	4.28e-01
GO:BP	GO:0040011	locomotion	4	854	4.28e-01
GO:BP	GO:0032446	protein modification by small protein conjugation	3	759	4.28e-01
GO:BP	GO:0048754	branching morphogenesis of an epithelial tube	1	121	4.28e-01
GO:BP	GO:0023051	regulation of signaling	9	2560	4.30e-01
GO:BP	GO:0015850	organic hydroxy compound transport	1	181	4.30e-01
GO:BP	GO:1901617	organic hydroxy compound biosynthetic process	1	174	4.30e-01
GO:BP	GO:0006950	response to stress	1	2763	4.30e-01
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	2	296	4.31e-01
GO:BP	GO:0010646	regulation of cell communication	9	2567	4.33e-01
GO:BP	GO:0055123	digestive system development	1	100	4.33e-01
GO:BP	GO:0048731	system development	1	2886	4.33e-01
GO:BP	GO:0048568	embryonic organ development	2	314	4.33e-01
GO:BP	GO:0008366	axon ensheathment	1	116	4.33e-01
GO:BP	GO:1901990	regulation of mitotic cell cycle phase transition	1	305	4.33e-01
GO:BP	GO:0007272	ensheathment of neurons	1	116	4.33e-01
GO:BP	GO:0030072	peptide hormone secretion	1	169	4.33e-01
GO:BP	GO:0008033	tRNA processing	1	131	4.33e-01
GO:BP	GO:0042552	myelination	1	114	4.33e-01
GO:BP	GO:0042221	response to chemical	1	2456	4.33e-01
GO:BP	GO:0003012	muscle system process	1	334	4.33e-01
GO:BP	GO:0007605	sensory perception of sound	1	97	4.33e-01
GO:BP	GO:0035051	cardiocyte differentiation	1	134	4.34e-01
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	1	3054	4.34e-01
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	1	3059	4.35e-01
GO:BP	GO:0051234	establishment of localization	2	3453	4.35e-01
GO:BP	GO:1903522	regulation of blood circulation	1	197	4.35e-01
GO:BP	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	1	123	4.35e-01
GO:BP	GO:0035108	limb morphogenesis	1	113	4.35e-01
GO:BP	GO:0035107	appendage morphogenesis	1	113	4.35e-01
GO:BP	GO:0002790	peptide secretion	1	173	4.35e-01
GO:BP	GO:0018130	heterocycle biosynthetic process	1	3115	4.38e-01
GO:BP	GO:0072331	signal transduction by p53 class mediator	1	163	4.38e-01
GO:BP	GO:0019438	aromatic compound biosynthetic process	1	3116	4.38e-01
GO:BP	GO:0072073	kidney epithelium development	1	113	4.38e-01
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	1	1203	4.38e-01
GO:BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	1	157	4.39e-01
GO:BP	GO:0046883	regulation of hormone secretion	1	171	4.40e-01
GO:BP	GO:0051179	localization	4	3983	4.40e-01
GO:BP	GO:0035264	multicellular organism growth	1	124	4.42e-01
GO:BP	GO:0007611	learning or memory	1	201	4.42e-01
GO:BP	GO:0071705	nitrogen compound transport	1	1689	4.43e-01
GO:BP	GO:0098662	inorganic cation transmembrane transport	3	537	4.44e-01
GO:BP	GO:0030030	cell projection organization	1	1236	4.44e-01
GO:BP	GO:0010639	negative regulation of organelle organization	1	310	4.44e-01
GO:BP	GO:0050708	regulation of protein secretion	1	186	4.46e-01
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	1	3221	4.46e-01
GO:BP	GO:0008202	steroid metabolic process	1	203	4.49e-01
GO:BP	GO:0015833	peptide transport	1	182	4.50e-01
GO:BP	GO:0001558	regulation of cell growth	1	352	4.50e-01
GO:BP	GO:0060070	canonical Wnt signaling pathway	1	254	4.53e-01
GO:BP	GO:0032102	negative regulation of response to external stimulus	1	291	4.53e-01
GO:BP	GO:0062012	regulation of small molecule metabolic process	1	248	4.53e-01
GO:BP	GO:0051649	establishment of localization in cell	1	1842	4.53e-01
GO:BP	GO:0042770	signal transduction in response to DNA damage	1	180	4.54e-01
GO:BP	GO:0043405	regulation of MAP kinase activity	1	141	4.57e-01
GO:BP	GO:0098655	monoatomic cation transmembrane transport	3	554	4.59e-01
GO:BP	GO:0050954	sensory perception of mechanical stimulus	1	111	4.61e-01
GO:BP	GO:0046578	regulation of Ras protein signal transduction	1	156	4.61e-01
GO:BP	GO:0010975	regulation of neuron projection development	1	374	4.61e-01
GO:BP	GO:0009888	tissue development	6	1425	4.61e-01
GO:BP	GO:0061351	neural precursor cell proliferation	1	122	4.61e-01
GO:BP	GO:0007409	axonogenesis	1	350	4.61e-01
GO:BP	GO:0048592	eye morphogenesis	1	114	4.61e-01
GO:BP	GO:0045786	negative regulation of cell cycle	1	337	4.61e-01
GO:BP	GO:0032880	regulation of protein localization	1	719	4.61e-01
GO:BP	GO:0030324	lung development	1	144	4.61e-01
GO:BP	GO:0061138	morphogenesis of a branching epithelium	1	143	4.61e-01
GO:BP	GO:0030323	respiratory tube development	1	148	4.66e-01
GO:BP	GO:0006109	regulation of carbohydrate metabolic process	1	147	4.66e-01
GO:BP	GO:0030001	metal ion transport	2	568	4.66e-01
GO:BP	GO:0007275	multicellular organism development	1	3355	4.66e-01
GO:BP	GO:0019216	regulation of lipid metabolic process	1	251	4.66e-01
GO:BP	GO:0010648	negative regulation of cell communication	4	1088	4.66e-01
GO:BP	GO:0051235	maintenance of location	1	263	4.66e-01
GO:BP	GO:0030111	regulation of Wnt signaling pathway	1	274	4.66e-01
GO:BP	GO:0023057	negative regulation of signaling	4	1090	4.66e-01
GO:BP	GO:0006935	chemotaxis	1	264	4.66e-01
GO:BP	GO:0140694	non-membrane-bounded organelle assembly	1	364	4.66e-01
GO:BP	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	1	144	4.66e-01
GO:BP	GO:0042330	taxis	1	264	4.66e-01
GO:BP	GO:0006518	peptide metabolic process	1	781	4.66e-01
GO:BP	GO:0031399	regulation of protein modification process	4	1096	4.67e-01
GO:BP	GO:0032879	regulation of localization	4	1570	4.70e-01
GO:BP	GO:0008104	protein localization	2	2128	4.72e-01
GO:BP	GO:0070727	cellular macromolecule localization	2	2137	4.73e-01
GO:BP	GO:0009967	positive regulation of signal transduction	5	1116	4.73e-01
GO:BP	GO:0001501	skeletal system development	2	361	4.76e-01
GO:BP	GO:0048839	inner ear development	1	129	4.76e-01
GO:BP	GO:0001763	morphogenesis of a branching structure	1	155	4.79e-01
GO:BP	GO:0071824	protein-DNA complex organization	2	711	4.79e-01
GO:BP	GO:0048736	appendage development	1	141	4.83e-01
GO:BP	GO:0060173	limb development	1	141	4.83e-01
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	1	3743	4.83e-01
GO:BP	GO:0006066	alcohol metabolic process	1	263	4.83e-01
GO:BP	GO:0046879	hormone secretion	1	212	4.83e-01
GO:BP	GO:0009416	response to light stimulus	1	241	4.84e-01
GO:BP	GO:0009410	response to xenobiotic stimulus	1	275	4.84e-01
GO:BP	GO:0098660	inorganic ion transmembrane transport	2	582	4.84e-01
GO:BP	GO:1901987	regulation of cell cycle phase transition	1	387	4.85e-01
GO:BP	GO:0016049	cell growth	1	416	4.85e-01
GO:BP	GO:0060341	regulation of cellular localization	1	805	4.85e-01
GO:BP	GO:0070374	positive regulation of ERK1 and ERK2 cascade	1	120	4.85e-01
GO:BP	GO:0060541	respiratory system development	1	161	4.86e-01
GO:BP	GO:0046394	carboxylic acid biosynthetic process	1	223	4.87e-01
GO:BP	GO:0061564	axon development	1	388	4.89e-01
GO:BP	GO:0050679	positive regulation of epithelial cell proliferation	1	152	4.89e-01
GO:BP	GO:0016053	organic acid biosynthetic process	1	224	4.89e-01
GO:BP	GO:0009914	hormone transport	1	217	4.89e-01
GO:BP	GO:0001932	regulation of protein phosphorylation	3	758	4.89e-01
GO:BP	GO:0051640	organelle localization	2	521	4.90e-01
GO:BP	GO:0009755	hormone-mediated signaling pathway	1	142	4.90e-01
GO:BP	GO:0009894	regulation of catabolic process	1	883	4.90e-01
GO:BP	GO:0070647	protein modification by small protein conjugation or removal	3	870	4.90e-01
GO:BP	GO:0044772	mitotic cell cycle phase transition	1	411	4.91e-01
GO:BP	GO:0045859	regulation of protein kinase activity	2	473	4.91e-01
GO:BP	GO:0032501	multicellular organismal process	9	4807	4.91e-01
GO:BP	GO:0040007	growth	3	737	4.94e-01
GO:BP	GO:0043086	negative regulation of catalytic activity	2	456	4.95e-01
GO:BP	GO:0015980	energy derivation by oxidation of organic compounds	1	288	4.96e-01
GO:BP	GO:0010810	regulation of cell-substrate adhesion	1	171	4.96e-01
GO:BP	GO:0016477	cell migration	2	1065	4.96e-01
GO:BP	GO:0030163	protein catabolic process	1	906	4.97e-01
GO:BP	GO:1901135	carbohydrate derivative metabolic process	1	841	5.00e-01
GO:BP	GO:0019752	carboxylic acid metabolic process	2	684	5.02e-01
GO:BP	GO:0043269	regulation of monoatomic ion transport	2	369	5.02e-01
GO:BP	GO:0043583	ear development	1	150	5.06e-01
GO:BP	GO:0051216	cartilage development	1	149	5.06e-01
GO:BP	GO:0006996	organelle organization	2	2974	5.09e-01
GO:BP	GO:0042886	amide transport	1	237	5.12e-01
GO:BP	GO:0006399	tRNA metabolic process	1	189	5.12e-01
GO:BP	GO:0048856	anatomical structure development	2	4100	5.12e-01
GO:BP	GO:0010632	regulation of epithelial cell migration	1	195	5.12e-01
GO:BP	GO:0043436	oxoacid metabolic process	2	699	5.12e-01
GO:BP	GO:0002064	epithelial cell development	1	156	5.12e-01
GO:BP	GO:0071356	cellular response to tumor necrosis factor	1	159	5.13e-01
GO:BP	GO:0048514	blood vessel morphogenesis	2	461	5.13e-01
GO:BP	GO:0006082	organic acid metabolic process	2	703	5.14e-01
GO:BP	GO:0010468	regulation of gene expression	1	3587	5.15e-01
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	1	451	5.15e-01
GO:BP	GO:0034330	cell junction organization	1	586	5.15e-01
GO:BP	GO:0009306	protein secretion	1	262	5.15e-01
GO:BP	GO:0051098	regulation of binding	1	314	5.15e-01
GO:BP	GO:0006869	lipid transport	1	271	5.15e-01
GO:BP	GO:0007346	regulation of mitotic cell cycle	1	438	5.15e-01
GO:BP	GO:0035592	establishment of protein localization to extracellular region	1	262	5.15e-01
GO:BP	GO:0048523	negative regulation of cellular process	1	3773	5.15e-01
GO:BP	GO:0031344	regulation of cell projection organization	2	542	5.20e-01
GO:BP	GO:0007507	heart development	2	512	5.20e-01
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	1	4243	5.20e-01
GO:BP	GO:0071692	protein localization to extracellular region	1	266	5.20e-01
GO:BP	GO:0034220	monoatomic ion transmembrane transport	2	650	5.21e-01
GO:BP	GO:2000241	regulation of reproductive process	1	126	5.21e-01
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	1	3702	5.22e-01
GO:BP	GO:0033036	macromolecule localization	1	2448	5.24e-01
GO:BP	GO:0048738	cardiac muscle tissue development	1	202	5.25e-01
GO:BP	GO:0022402	cell cycle process	4	1078	5.25e-01
GO:BP	GO:0048522	positive regulation of cellular process	1	4197	5.27e-01
GO:BP	GO:0033365	protein localization to organelle	1	860	5.27e-01
GO:BP	GO:0006812	monoatomic cation transport	2	677	5.27e-01
GO:BP	GO:0031326	regulation of cellular biosynthetic process	1	3794	5.30e-01
GO:BP	GO:0080090	regulation of primary metabolic process	1	4371	5.30e-01
GO:BP	GO:0009889	regulation of biosynthetic process	1	3820	5.32e-01
GO:BP	GO:0043603	amide metabolic process	1	1003	5.33e-01
GO:BP	GO:0034612	response to tumor necrosis factor	1	176	5.33e-01
GO:BP	GO:0040008	regulation of growth	1	493	5.33e-01
GO:BP	GO:0048598	embryonic morphogenesis	2	438	5.33e-01
GO:BP	GO:0006631	fatty acid metabolic process	1	276	5.34e-01
GO:BP	GO:0042325	regulation of phosphorylation	3	841	5.34e-01
GO:BP	GO:0048519	negative regulation of biological process	1	4026	5.39e-01
GO:BP	GO:0016055	Wnt signaling pathway	1	379	5.42e-01
GO:BP	GO:0036211	protein modification process	1	2751	5.42e-01
GO:BP	GO:0010876	lipid localization	1	309	5.42e-01
GO:BP	GO:0048812	neuron projection morphogenesis	1	500	5.42e-01
GO:BP	GO:0044770	cell cycle phase transition	1	496	5.42e-01
GO:BP	GO:0198738	cell-cell signaling by wnt	1	380	5.42e-01
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	1	529	5.42e-01
GO:BP	GO:0003007	heart morphogenesis	1	217	5.42e-01
GO:BP	GO:0043549	regulation of kinase activity	2	548	5.47e-01
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	1	515	5.47e-01
GO:BP	GO:1903039	positive regulation of leukocyte cell-cell adhesion	1	157	5.49e-01
GO:BP	GO:0006417	regulation of translation	1	373	5.49e-01
GO:BP	GO:0048858	cell projection morphogenesis	1	519	5.49e-01
GO:BP	GO:0042592	homeostatic process	5	1189	5.51e-01
GO:BP	GO:0071495	cellular response to endogenous stimulus	4	1097	5.53e-01
GO:BP	GO:0009887	animal organ morphogenesis	3	725	5.53e-01
GO:BP	GO:0009314	response to radiation	1	339	5.53e-01
GO:BP	GO:0051049	regulation of transport	3	1268	5.53e-01
GO:BP	GO:0009966	regulation of signal transduction	7	2271	5.53e-01
GO:BP	GO:0045765	regulation of angiogenesis	1	200	5.53e-01
GO:BP	GO:0032502	developmental process	2	4445	5.55e-01
GO:BP	GO:0051276	chromosome organization	2	533	5.55e-01
GO:BP	GO:0032990	cell part morphogenesis	1	539	5.55e-01
GO:BP	GO:1901342	regulation of vasculature development	1	202	5.55e-01
GO:BP	GO:0048518	positive regulation of biological process	1	4566	5.55e-01
GO:BP	GO:0010647	positive regulation of cell communication	5	1249	5.57e-01
GO:BP	GO:0023056	positive regulation of signaling	5	1252	5.57e-01
GO:BP	GO:0043412	macromolecule modification	1	2948	5.57e-01
GO:BP	GO:0045165	cell fate commitment	1	157	5.57e-01
GO:BP	GO:0051641	cellular localization	1	2822	5.59e-01
GO:BP	GO:0051345	positive regulation of hydrolase activity	1	412	5.60e-01
GO:BP	GO:0001568	blood vessel development	2	537	5.60e-01
GO:BP	GO:0006915	apoptotic process	5	1452	5.68e-01
GO:BP	GO:0098609	cell-cell adhesion	1	599	5.68e-01
GO:BP	GO:0035295	tube development	3	822	5.68e-01
GO:BP	GO:1901565	organonitrogen compound catabolic process	1	1151	5.68e-01
GO:BP	GO:0009057	macromolecule catabolic process	1	1215	5.75e-01
GO:BP	GO:0018105	peptidyl-serine phosphorylation	1	242	5.78e-01
GO:BP	GO:0021537	telencephalon development	1	208	5.78e-01
GO:BP	GO:0048878	chemical homeostasis	3	689	5.78e-01
GO:BP	GO:1903047	mitotic cell cycle process	2	689	5.78e-01
GO:BP	GO:0044281	small molecule metabolic process	3	1386	5.78e-01
GO:BP	GO:0001944	vasculature development	2	562	5.79e-01
GO:BP	GO:0051346	negative regulation of hydrolase activity	1	206	5.79e-01
GO:BP	GO:0061448	connective tissue development	1	212	5.83e-01
GO:BP	GO:0010631	epithelial cell migration	1	253	5.83e-01
GO:BP	GO:0034248	regulation of amide metabolic process	1	426	5.83e-01
GO:BP	GO:0051146	striated muscle cell differentiation	1	239	5.83e-01
GO:BP	GO:0031323	regulation of cellular metabolic process	1	4563	5.83e-01
GO:BP	GO:0090132	epithelium migration	1	253	5.84e-01
GO:BP	GO:0072359	circulatory system development	3	888	5.85e-01
GO:BP	GO:0060255	regulation of macromolecule metabolic process	1	4593	5.85e-01
GO:BP	GO:0023061	signal release	1	329	5.85e-01
GO:BP	GO:0006811	monoatomic ion transport	1	788	5.88e-01
GO:BP	GO:0090130	tissue migration	1	257	5.89e-01
GO:BP	GO:0050877	nervous system process	1	628	5.89e-01
GO:BP	GO:0022409	positive regulation of cell-cell adhesion	1	188	5.89e-01
GO:BP	GO:0018209	peptidyl-serine modification	1	254	5.90e-01
GO:BP	GO:0009059	macromolecule biosynthetic process	2	5148	5.92e-01
GO:BP	GO:0012501	programmed cell death	5	1498	5.93e-01
GO:BP	GO:0032989	cellular component morphogenesis	1	627	5.93e-01
GO:BP	GO:0016070	RNA metabolic process	1	3573	5.93e-01
GO:BP	GO:0030198	extracellular matrix organization	1	233	5.94e-01
GO:BP	GO:0019220	regulation of phosphate metabolic process	3	949	5.94e-01
GO:BP	GO:0008219	cell death	5	1504	5.94e-01
GO:BP	GO:0043062	extracellular structure organization	1	234	5.94e-01
GO:BP	GO:0051174	regulation of phosphorus metabolic process	3	950	5.94e-01
GO:BP	GO:0045229	external encapsulating structure organization	1	234	5.94e-01
GO:BP	GO:0060562	epithelial tube morphogenesis	1	276	5.97e-01
GO:BP	GO:0007265	Ras protein signal transduction	1	287	5.97e-01
GO:BP	GO:0051223	regulation of protein transport	1	404	5.98e-01
GO:BP	GO:0006091	generation of precursor metabolites and energy	1	423	5.98e-01
GO:BP	GO:0043687	post-translational protein modification	3	1102	5.99e-01
GO:BP	GO:0065009	regulation of molecular function	6	1905	6.07e-01
GO:BP	GO:0007420	brain development	2	546	6.08e-01
GO:BP	GO:0071900	regulation of protein serine/threonine kinase activity	1	274	6.10e-01
GO:BP	GO:0010564	regulation of cell cycle process	1	622	6.12e-01
GO:BP	GO:0070201	regulation of establishment of protein localization	1	428	6.13e-01
GO:BP	GO:0019222	regulation of metabolic process	1	4998	6.14e-01
GO:BP	GO:0051338	regulation of transferase activity	2	664	6.15e-01
GO:BP	GO:0010817	regulation of hormone levels	1	337	6.17e-01
GO:BP	GO:0031589	cell-substrate adhesion	1	271	6.18e-01
GO:BP	GO:0044057	regulation of system process	1	398	6.20e-01
GO:BP	GO:0051716	cellular response to stimulus	1	4929	6.20e-01
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	1	680	6.21e-01
GO:BP	GO:0090304	nucleic acid metabolic process	1	4018	6.25e-01
GO:BP	GO:0071345	cellular response to cytokine stimulus	2	544	6.25e-01
GO:BP	GO:0080134	regulation of response to stress	3	1074	6.25e-01
GO:BP	GO:1903530	regulation of secretion by cell	1	382	6.26e-01
GO:BP	GO:0006874	intracellular calcium ion homeostasis	1	208	6.27e-01
GO:BP	GO:0030522	intracellular receptor signaling pathway	1	256	6.29e-01
GO:BP	GO:1903037	regulation of leukocyte cell-cell adhesion	1	210	6.29e-01
GO:BP	GO:0050678	regulation of epithelial cell proliferation	1	268	6.30e-01
GO:BP	GO:0065003	protein-containing complex assembly	1	1320	6.32e-01
GO:BP	GO:0060322	head development	2	588	6.35e-01
GO:BP	GO:0060429	epithelium development	3	849	6.35e-01
GO:BP	GO:0044283	small molecule biosynthetic process	1	432	6.35e-01
GO:BP	GO:0035239	tube morphogenesis	2	663	6.49e-01
GO:BP	GO:0009719	response to endogenous stimulus	4	1260	6.49e-01
GO:BP	GO:0055074	calcium ion homeostasis	1	221	6.51e-01
GO:BP	GO:0000902	cell morphogenesis	1	740	6.53e-01
GO:BP	GO:0000278	mitotic cell cycle	2	815	6.55e-01
GO:BP	GO:0051046	regulation of secretion	1	413	6.55e-01
GO:BP	GO:0007610	behavior	1	439	6.55e-01
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	1	4423	6.55e-01
GO:BP	GO:0032787	monocarboxylic acid metabolic process	1	434	6.59e-01
GO:BP	GO:0007159	leukocyte cell-cell adhesion	1	233	6.61e-01
GO:BP	GO:0051246	regulation of protein metabolic process	5	1895	6.62e-01
GO:BP	GO:0031175	neuron projection development	1	774	6.63e-01
GO:BP	GO:0006629	lipid metabolic process	2	989	6.65e-01
GO:BP	GO:0046483	heterocycle metabolic process	1	4537	6.66e-01
GO:BP	GO:0044249	cellular biosynthetic process	2	5813	6.67e-01
GO:BP	GO:0006725	cellular aromatic compound metabolic process	1	4561	6.69e-01
GO:BP	GO:0042692	muscle cell differentiation	1	329	6.69e-01
GO:BP	GO:0048513	animal organ development	7	2156	6.70e-01
GO:BP	GO:0051336	regulation of hydrolase activity	2	680	6.71e-01
GO:BP	GO:0006338	chromatin remodeling	1	520	6.71e-01
GO:BP	GO:0034097	response to cytokine	2	609	6.71e-01
GO:BP	GO:0007600	sensory perception	2	259	6.71e-01
GO:BP	GO:1901576	organic substance biosynthetic process	2	5875	6.73e-01
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	2	741	6.78e-01
GO:BP	GO:0009058	biosynthetic process	2	5912	6.78e-01
GO:BP	GO:1901360	organic cyclic compound metabolic process	1	4713	6.82e-01
GO:BP	GO:0032101	regulation of response to external stimulus	1	690	6.83e-01
GO:BP	GO:0048583	regulation of response to stimulus	8	2877	6.84e-01
GO:BP	GO:0050673	epithelial cell proliferation	1	318	6.86e-01
GO:BP	GO:0030900	forebrain development	1	290	6.88e-01
GO:BP	GO:0006468	protein phosphorylation	3	1130	6.89e-01
GO:BP	GO:0019538	protein metabolic process	1	4202	6.91e-01
GO:BP	GO:0034641	cellular nitrogen compound metabolic process	1	4913	6.91e-01
GO:BP	GO:0023052	signaling	10	4134	6.97e-01
GO:BP	GO:1901575	organic substance catabolic process	1	1731	7.05e-01
GO:BP	GO:0043933	protein-containing complex organization	1	1964	7.07e-01
GO:BP	GO:0007155	cell adhesion	1	996	7.07e-01
GO:BP	GO:0048666	neuron development	1	873	7.07e-01
GO:BP	GO:0022407	regulation of cell-cell adhesion	1	292	7.08e-01
GO:BP	GO:0045785	positive regulation of cell adhesion	1	319	7.08e-01
GO:BP	GO:0050896	response to stimulus	1	5721	7.12e-01
GO:BP	GO:0006412	translation	1	657	7.18e-01
GO:BP	GO:0007154	cell communication	10	4210	7.19e-01
GO:BP	GO:0034470	ncRNA processing	1	397	7.21e-01
GO:BP	GO:0007417	central nervous system development	1	750	7.22e-01
GO:BP	GO:0006259	DNA metabolic process	1	886	7.23e-01
GO:BP	GO:0010467	gene expression	1	4733	7.26e-01
GO:BP	GO:0006325	chromatin organization	1	631	7.29e-01
GO:BP	GO:0043043	peptide biosynthetic process	1	677	7.29e-01
GO:BP	GO:0002009	morphogenesis of an epithelium	1	415	7.30e-01
GO:BP	GO:0001525	angiogenesis	1	389	7.33e-01
GO:BP	GO:0032940	secretion by cell	1	573	7.43e-01
GO:BP	GO:0048584	positive regulation of response to stimulus	5	1557	7.43e-01
GO:BP	GO:0033993	response to lipid	1	594	7.60e-01
GO:BP	GO:0033043	regulation of organelle organization	1	1001	7.60e-01
GO:BP	GO:0014070	response to organic cyclic compound	1	634	7.60e-01
GO:BP	GO:0022607	cellular component assembly	1	2459	7.61e-01
GO:BP	GO:0043085	positive regulation of catalytic activity	1	815	7.61e-01
GO:BP	GO:1901564	organonitrogen compound metabolic process	1	4919	7.62e-01
GO:BP	GO:0140352	export from cell	1	617	7.67e-01
GO:BP	GO:0009056	catabolic process	1	2108	7.67e-01
GO:BP	GO:0016310	phosphorylation	3	1338	7.79e-01
GO:BP	GO:0043604	amide biosynthetic process	1	785	7.82e-01
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	1	470	7.82e-01
GO:BP	GO:0044085	cellular component biogenesis	1	2722	7.83e-01
GO:BP	GO:0051128	regulation of cellular component organization	2	1981	7.83e-01
GO:BP	GO:0030003	intracellular monoatomic cation homeostasis	1	364	7.84e-01
GO:BP	GO:0098771	inorganic ion homeostasis	1	355	7.88e-01
GO:BP	GO:0046903	secretion	1	647	7.88e-01
GO:BP	GO:0006873	intracellular monoatomic ion homeostasis	1	369	7.88e-01
GO:BP	GO:0048729	tissue morphogenesis	1	501	7.88e-01
GO:BP	GO:0009790	embryo development	2	859	7.91e-01
GO:BP	GO:0050790	regulation of catalytic activity	3	1349	7.92e-01
GO:BP	GO:0044255	cellular lipid metabolic process	1	736	8.03e-01
GO:BP	GO:0032870	cellular response to hormone stimulus	1	449	8.03e-01
GO:BP	GO:0001934	positive regulation of protein phosphorylation	1	465	8.03e-01
GO:BP	GO:0055080	monoatomic cation homeostasis	1	410	8.26e-01
GO:BP	GO:0006807	nitrogen compound metabolic process	2	7431	8.29e-01
GO:BP	GO:0010608	post-transcriptional regulation of gene expression	1	475	8.29e-01
GO:BP	GO:0050801	monoatomic ion homeostasis	1	416	8.29e-01
GO:BP	GO:0034660	ncRNA metabolic process	1	561	8.30e-01
GO:BP	GO:0042327	positive regulation of phosphorylation	1	511	8.31e-01
GO:BP	GO:0009628	response to abiotic stimulus	1	848	8.33e-01
GO:BP	GO:0065008	regulation of biological quality	3	2085	8.40e-01
GO:BP	GO:0043170	macromolecule metabolic process	2	7084	8.54e-01
GO:BP	GO:0007186	G protein-coupled receptor signaling pathway	1	386	8.54e-01
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	1	559	8.56e-01
GO:BP	GO:0030155	regulation of cell adhesion	1	535	8.56e-01
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	1	559	8.56e-01
GO:BP	GO:0044093	positive regulation of molecular function	1	1132	8.56e-01
GO:BP	GO:0006974	DNA damage response	1	795	8.67e-01
GO:BP	GO:0055082	intracellular chemical homeostasis	1	498	8.74e-01
GO:BP	GO:0043066	negative regulation of apoptotic process	1	662	8.84e-01
GO:BP	GO:0031401	positive regulation of protein modification process	1	664	8.86e-01
GO:BP	GO:0050794	regulation of cellular process	1	7632	8.90e-01
GO:BP	GO:0043069	negative regulation of programmed cell death	1	685	8.90e-01
GO:BP	GO:0044238	primary metabolic process	2	7788	8.93e-01
GO:BP	GO:0071310	cellular response to organic substance	3	1390	8.93e-01
GO:BP	GO:0007166	cell surface receptor signaling pathway	4	1889	8.95e-01
GO:BP	GO:0009725	response to hormone	1	624	8.98e-01
GO:BP	GO:0019725	cellular homeostasis	1	583	9.06e-01
GO:BP	GO:0044087	regulation of cellular component biogenesis	1	802	9.10e-01
GO:BP	GO:0007165	signal transduction	11	3803	9.12e-01
GO:BP	GO:0009653	anatomical structure morphogenesis	4	1952	9.20e-01
GO:BP	GO:0044237	cellular metabolic process	2	7562	9.21e-01
GO:BP	GO:0050789	regulation of biological process	1	8017	9.25e-01
GO:BP	GO:0016043	cellular component organization	2	5106	9.27e-01
GO:BP	GO:0009605	response to external stimulus	2	1635	9.30e-01
GO:BP	GO:0010033	response to organic substance	4	1942	9.31e-01
GO:BP	GO:1901700	response to oxygen-containing compound	1	1219	9.34e-01
GO:BP	GO:0071840	cellular component organization or biogenesis	2	5307	9.35e-01
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	1	868	9.40e-01
GO:BP	GO:0010628	positive regulation of gene expression	1	795	9.41e-01
GO:BP	GO:0065007	biological regulation	1	8282	9.50e-01
GO:BP	GO:0006796	phosphate-containing compound metabolic process	3	2096	9.56e-01
GO:BP	GO:0006793	phosphorus metabolic process	3	2118	9.58e-01
GO:BP	GO:0000398	mRNA splicing, via spliceosome	1	288	9.63e-01
GO:BP	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1	288	9.63e-01
GO:BP	GO:0000375	RNA splicing, via transesterification reactions	1	292	9.63e-01
GO:BP	GO:0051247	positive regulation of protein metabolic process	1	1067	9.63e-01
GO:BP	GO:0008380	RNA splicing	2	426	9.64e-01
GO:BP	GO:0006397	mRNA processing	2	451	9.67e-01
GO:BP	GO:0016071	mRNA metabolic process	2	671	9.84e-01
GO:BP	GO:0009987	cellular process	1	11410	1.00e+00
GO:BP	GO:0006396	RNA processing	1	928	1.00e+00
GO:BP	GO:0008150	biological_process	1	12027	1.00e+00
GO:BP	GO:0008152	metabolic process	1	8522	1.00e+00
GO:BP	GO:0071704	organic substance metabolic process	1	8176	1.00e+00
KEGG	KEGG:05202	Transcriptional misregulation in cancer	4	128	8.80e-03
KEGG	KEGG:05223	Non-small cell lung cancer	3	67	1.20e-02
KEGG	KEGG:05222	Small cell lung cancer	3	87	1.53e-02
KEGG	KEGG:05216	Thyroid cancer	2	35	1.53e-02
KEGG	KEGG:05226	Gastric cancer	3	117	2.09e-02
KEGG	KEGG:05212	Pancreatic cancer	2	75	2.09e-02
KEGG	KEGG:05213	Endometrial cancer	2	57	2.09e-02
KEGG	KEGG:05214	Glioma	2	67	2.09e-02
KEGG	KEGG:05215	Prostate cancer	1	86	2.09e-02
KEGG	KEGG:05217	Basal cell carcinoma	2	49	2.09e-02
KEGG	KEGG:04115	p53 signaling pathway	2	65	2.09e-02
KEGG	KEGG:05218	Melanoma	2	58	2.09e-02
KEGG	KEGG:05220	Chronic myeloid leukemia	2	75	2.09e-02
KEGG	KEGG:05210	Colorectal cancer	2	84	2.29e-02
KEGG	KEGG:04064	NF-kappa B signaling pathway	2	71	2.96e-02
KEGG	KEGG:04068	FoxO signaling pathway	2	109	4.44e-02
KEGG	KEGG:04210	Apoptosis	2	118	4.44e-02
KEGG	KEGG:00510	N-Glycan biosynthesis	1	48	4.62e-02
KEGG	KEGG:05224	Breast cancer	2	117	4.66e-02
KEGG	KEGG:04110	Cell cycle	2	151	4.77e-02
KEGG	KEGG:04218	Cellular senescence	2	145	4.77e-02
KEGG	KEGG:05225	Hepatocellular carcinoma	2	145	5.04e-02
KEGG	KEGG:05169	Epstein-Barr virus infection	2	153	6.66e-02
KEGG	KEGG:04710	Circadian rhythm	1	30	7.37e-02
KEGG	KEGG:05016	Huntington disease	1	256	1.00e-01
KEGG	KEGG:05014	Amyotrophic lateral sclerosis	1	303	1.14e-01
KEGG	KEGG:04010	MAPK signaling pathway	2	240	1.14e-01
KEGG	KEGG:05221	Acute myeloid leukemia	1	56	1.22e-01
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	1	385	1.32e-01
KEGG	KEGG:04713	Circadian entrainment	1	69	1.56e-01
KEGG	KEGG:05200	Pathways in cancer	3	409	1.56e-01
KEGG	KEGG:04360	Axon guidance	1	162	1.77e-01
KEGG	KEGG:04114	Oocyte meiosis	1	108	3.11e-01
KEGG	KEGG:04080	Neuroactive ligand-receptor interaction	1	108	4.34e-01
KEGG	KEGG:05206	MicroRNAs in cancer	1	149	5.30e-01
KEGG	KEGG:01100	Metabolic pathways	1	1146	5.41e-01
KEGG	KEGG:05168	Herpes simplex virus 1 infection	1	415	6.12e-01
KEGG	KEGG:00000	KEGG root term	1	5548	6.12e-01

TRZnomtable %>%
  filter(source=="KEGG") %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "Enrichment of KEGG terms using nominal pvalue TRZ genes in my data") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

Enrichment of KEGG terms using nominal pvalue TRZ genes in my data

source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:05202	Transcriptional misregulation in cancer	4	128	8.80e-03
KEGG	KEGG:05223	Non-small cell lung cancer	3	67	1.20e-02
KEGG	KEGG:05222	Small cell lung cancer	3	87	1.53e-02
KEGG	KEGG:05216	Thyroid cancer	2	35	1.53e-02
KEGG	KEGG:05226	Gastric cancer	3	117	2.09e-02
KEGG	KEGG:05212	Pancreatic cancer	2	75	2.09e-02
KEGG	KEGG:05213	Endometrial cancer	2	57	2.09e-02
KEGG	KEGG:05214	Glioma	2	67	2.09e-02
KEGG	KEGG:05215	Prostate cancer	1	86	2.09e-02
KEGG	KEGG:05217	Basal cell carcinoma	2	49	2.09e-02
KEGG	KEGG:04115	p53 signaling pathway	2	65	2.09e-02
KEGG	KEGG:05218	Melanoma	2	58	2.09e-02
KEGG	KEGG:05220	Chronic myeloid leukemia	2	75	2.09e-02
KEGG	KEGG:05210	Colorectal cancer	2	84	2.29e-02
KEGG	KEGG:04064	NF-kappa B signaling pathway	2	71	2.96e-02
KEGG	KEGG:04068	FoxO signaling pathway	2	109	4.44e-02
KEGG	KEGG:04210	Apoptosis	2	118	4.44e-02
KEGG	KEGG:00510	N-Glycan biosynthesis	1	48	4.62e-02
KEGG	KEGG:05224	Breast cancer	2	117	4.66e-02
KEGG	KEGG:04110	Cell cycle	2	151	4.77e-02
KEGG	KEGG:04218	Cellular senescence	2	145	4.77e-02
KEGG	KEGG:05225	Hepatocellular carcinoma	2	145	5.04e-02
KEGG	KEGG:05169	Epstein-Barr virus infection	2	153	6.66e-02
KEGG	KEGG:04710	Circadian rhythm	1	30	7.37e-02
KEGG	KEGG:05016	Huntington disease	1	256	1.00e-01
KEGG	KEGG:05014	Amyotrophic lateral sclerosis	1	303	1.14e-01
KEGG	KEGG:04010	MAPK signaling pathway	2	240	1.14e-01
KEGG	KEGG:05221	Acute myeloid leukemia	1	56	1.22e-01
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	1	385	1.32e-01
KEGG	KEGG:04713	Circadian entrainment	1	69	1.56e-01
KEGG	KEGG:05200	Pathways in cancer	3	409	1.56e-01
KEGG	KEGG:04360	Axon guidance	1	162	1.77e-01
KEGG	KEGG:04114	Oocyte meiosis	1	108	3.11e-01
KEGG	KEGG:04080	Neuroactive ligand-receptor interaction	1	108	4.34e-01
KEGG	KEGG:05206	MicroRNAs in cancer	1	149	5.30e-01
KEGG	KEGG:01100	Metabolic pathways	1	1146	5.41e-01
KEGG	KEGG:05168	Herpes simplex virus 1 infection	1	415	6.12e-01
KEGG	KEGG:00000	KEGG root term	1	5548	6.12e-01

TRZ 3 hour nom de

# TRZresgenes3h <- gost(query = TRZ_list3h$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = TRUE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = backGL$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(TRZresgenes3h,"data/DEG-GO/TRZresgenes3h.RDS")
TRZresgenes3h <- readRDS("data/DEG-GO/TRZresgenes3h.RDS")

TRZnom3h <- gostplot(TRZresgenes3h, capped = FALSE, interactive = TRUE)
TRZnom3h

TRZnomtable3h <- TRZresgenes3h$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

TRZnomtable3h %>%
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:1900745	positive regulation of p38MAPK cascade	2	22	6.71e-03
GO:BP	GO:1902746	regulation of lens fiber cell differentiation	2	8	6.71e-03
GO:BP	GO:1902747	negative regulation of lens fiber cell differentiation	2	5	6.71e-03
GO:BP	GO:0120162	positive regulation of cold-induced thermogenesis	2	72	8.98e-03
GO:BP	GO:1900744	regulation of p38MAPK cascade	2	32	8.98e-03
GO:BP	GO:0038066	p38MAPK cascade	2	42	1.06e-02
GO:BP	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	2	15	1.06e-02
GO:BP	GO:0120161	regulation of cold-induced thermogenesis	2	115	1.12e-02
GO:BP	GO:0106106	cold-induced thermogenesis	2	116	1.12e-02
GO:BP	GO:1990845	adaptive thermogenesis	2	127	1.25e-02
GO:BP	GO:0001659	temperature homeostasis	2	135	1.35e-02
GO:BP	GO:0097167	circadian regulation of translation	1	4	1.51e-02
GO:BP	GO:0010719	negative regulation of epithelial to mesenchymal transition	2	29	1.51e-02
GO:BP	GO:0031400	negative regulation of protein modification process	4	396	1.51e-02
GO:BP	GO:0019249	lactate biosynthetic process	1	3	1.51e-02
GO:BP	GO:0001837	epithelial to mesenchymal transition	3	139	1.51e-02
GO:BP	GO:0046330	positive regulation of JNK cascade	2	71	1.51e-02
GO:BP	GO:0051941	regulation of amino acid uptake involved in synaptic transmission	1	3	1.51e-02
GO:BP	GO:0051946	regulation of glutamate uptake involved in transmission of nerve impulse	1	3	1.51e-02
GO:BP	GO:0070345	negative regulation of fat cell proliferation	1	4	1.51e-02
GO:BP	GO:0070306	lens fiber cell differentiation	2	30	1.61e-02
GO:BP	GO:0051935	glutamate reuptake	1	4	1.65e-02
GO:BP	GO:0070304	positive regulation of stress-activated protein kinase signaling cascade	2	97	1.74e-02
GO:BP	GO:0032874	positive regulation of stress-activated MAPK cascade	2	95	1.74e-02
GO:BP	GO:0010799	regulation of peptidyl-threonine phosphorylation	2	35	1.74e-02
GO:BP	GO:0002036	regulation of L-glutamate import across plasma membrane	1	6	1.86e-02
GO:BP	GO:0046328	regulation of JNK cascade	2	113	1.90e-02
GO:BP	GO:0030857	negative regulation of epithelial cell differentiation	2	31	2.01e-02
GO:BP	GO:0051933	amino acid neurotransmitter reuptake	1	5	2.01e-02
GO:BP	GO:0070344	regulation of fat cell proliferation	1	8	2.01e-02
GO:BP	GO:0042754	negative regulation of circadian rhythm	1	8	2.27e-02
GO:BP	GO:0045210	FasL biosynthetic process	1	1	2.27e-02
GO:BP	GO:0043065	positive regulation of apoptotic process	3	394	2.35e-02
GO:BP	GO:0007254	JNK cascade	2	137	2.35e-02
GO:BP	GO:1903789	regulation of amino acid transmembrane transport	1	14	2.39e-02
GO:BP	GO:0048762	mesenchymal cell differentiation	3	205	2.39e-02
GO:BP	GO:0070341	fat cell proliferation	1	11	2.39e-02
GO:BP	GO:0010958	regulation of amino acid import across plasma membrane	1	14	2.39e-02
GO:BP	GO:0070302	regulation of stress-activated protein kinase signaling cascade	2	157	2.39e-02
GO:BP	GO:0043068	positive regulation of programmed cell death	3	403	2.39e-02
GO:BP	GO:0032872	regulation of stress-activated MAPK cascade	2	153	2.39e-02
GO:BP	GO:0098712	L-glutamate import across plasma membrane	1	11	2.44e-02
GO:BP	GO:0050872	white fat cell differentiation	1	15	2.44e-02
GO:BP	GO:0070373	negative regulation of ERK1 and ERK2 cascade	2	58	2.44e-02
GO:BP	GO:0000271	polysaccharide biosynthetic process	2	54	2.44e-02
GO:BP	GO:0051580	regulation of neurotransmitter uptake	1	15	2.44e-02
GO:BP	GO:2000678	negative regulation of transcription regulatory region DNA binding	1	17	2.44e-02
GO:BP	GO:0043408	regulation of MAPK cascade	4	473	2.47e-02
GO:BP	GO:0006089	lactate metabolic process	1	16	2.47e-02
GO:BP	GO:0001933	negative regulation of protein phosphorylation	3	265	2.73e-02
GO:BP	GO:0043153	entrainment of circadian clock by photoperiod	1	23	2.79e-02
GO:BP	GO:0051403	stress-activated MAPK cascade	2	188	2.79e-02
GO:BP	GO:0031098	stress-activated protein kinase signaling cascade	2	194	2.89e-02
GO:BP	GO:0031397	negative regulation of protein ubiquitination	2	76	2.97e-02
GO:BP	GO:0009648	photoperiodism	1	24	2.97e-02
GO:BP	GO:0015813	L-glutamate transmembrane transport	1	18	2.99e-02
GO:BP	GO:0009649	entrainment of circadian clock	1	27	2.99e-02
GO:BP	GO:0051726	regulation of cell cycle	3	941	2.99e-02
GO:BP	GO:0042326	negative regulation of phosphorylation	3	290	2.99e-02
GO:BP	GO:0060485	mesenchyme development	3	250	3.09e-02
GO:BP	GO:0002088	lens development in camera-type eye	2	57	3.09e-02
GO:BP	GO:1900623	regulation of monocyte aggregation	1	3	3.11e-02
GO:BP	GO:0045226	extracellular polysaccharide biosynthetic process	1	2	3.11e-02
GO:BP	GO:0098810	neurotransmitter reuptake	1	21	3.11e-02
GO:BP	GO:0046379	extracellular polysaccharide metabolic process	1	2	3.11e-02
GO:BP	GO:0051938	L-glutamate import	1	24	3.11e-02
GO:BP	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	2	85	3.11e-02
GO:BP	GO:1900625	positive regulation of monocyte aggregation	1	3	3.11e-02
GO:BP	GO:0000165	MAPK cascade	4	553	3.11e-02
GO:BP	GO:1903321	negative regulation of protein modification by small protein conjugation or removal	2	86	3.11e-02
GO:BP	GO:0010717	regulation of epithelial to mesenchymal transition	2	87	3.20e-02
GO:BP	GO:0010563	negative regulation of phosphorus metabolic process	3	335	3.45e-02
GO:BP	GO:0009250	glucan biosynthetic process	1	40	3.45e-02
GO:BP	GO:0018107	peptidyl-threonine phosphorylation	2	96	3.45e-02
GO:BP	GO:0045936	negative regulation of phosphate metabolic process	3	334	3.45e-02
GO:BP	GO:0001504	neurotransmitter uptake	1	29	3.45e-02
GO:BP	GO:0005978	glycogen biosynthetic process	1	40	3.45e-02
GO:BP	GO:0051955	regulation of amino acid transport	1	28	3.45e-02
GO:BP	GO:0005976	polysaccharide metabolic process	2	81	3.45e-02
GO:BP	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway	1	3	3.45e-02
GO:BP	GO:1901874	negative regulation of post-translational protein modification	2	98	3.45e-02
GO:BP	GO:0048871	multicellular organismal-level homeostasis	2	570	3.48e-02
GO:BP	GO:0043392	negative regulation of DNA binding	1	44	3.48e-02
GO:BP	GO:1900127	positive regulation of hyaluronan biosynthetic process	1	4	3.48e-02
GO:BP	GO:0090500	endocardial cushion to mesenchymal transition	1	4	3.48e-02
GO:BP	GO:0089718	amino acid import across plasma membrane	1	38	3.51e-02
GO:BP	GO:0000379	tRNA-type intron splice site recognition and cleavage	1	3	3.54e-02
GO:BP	GO:2000677	regulation of transcription regulatory region DNA binding	1	43	3.57e-02
GO:BP	GO:0018210	peptidyl-threonine modification	2	103	3.61e-02
GO:BP	GO:0060437	lung growth	1	4	3.69e-02
GO:BP	GO:0002931	response to ischemia	1	48	3.92e-02
GO:BP	GO:0070487	monocyte aggregation	1	4	3.93e-02
GO:BP	GO:0015800	acidic amino acid transport	1	39	4.03e-02
GO:BP	GO:0019229	regulation of vasoconstriction	1	38	4.05e-02
GO:BP	GO:0034089	establishment of meiotic sister chromatid cohesion	1	4	4.06e-02
GO:BP	GO:1901842	negative regulation of high voltage-gated calcium channel activity	1	4	4.08e-02
GO:BP	GO:1902475	L-alpha-amino acid transmembrane transport	1	51	4.30e-02
GO:BP	GO:0032922	circadian regulation of gene expression	1	63	4.32e-02
GO:BP	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	2	126	4.34e-02
GO:BP	GO:0070295	renal water absorption	1	6	4.34e-02
GO:BP	GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	2	127	4.35e-02
GO:BP	GO:0005977	glycogen metabolic process	1	64	4.35e-02
GO:BP	GO:0060449	bud elongation involved in lung branching	1	7	4.35e-02
GO:BP	GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	2	122	4.35e-02
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	4	707	4.35e-02
GO:BP	GO:0060349	bone morphogenesis	2	74	4.35e-02
GO:BP	GO:0032890	regulation of organic acid transport	1	48	4.35e-02
GO:BP	GO:0044042	glucan metabolic process	1	65	4.35e-02
GO:BP	GO:0043410	positive regulation of MAPK cascade	3	316	4.41e-02
GO:BP	GO:0051248	negative regulation of protein metabolic process	4	799	4.41e-02
GO:BP	GO:0042310	vasoconstriction	1	51	4.46e-02
GO:BP	GO:1900125	regulation of hyaluronan biosynthetic process	1	6	4.52e-02
GO:BP	GO:0015807	L-amino acid transport	1	62	4.53e-02
GO:BP	GO:0030856	regulation of epithelial cell differentiation	2	100	4.53e-02
GO:BP	GO:0006112	energy reserve metabolic process	1	72	4.53e-02
GO:BP	GO:0006094	gluconeogenesis	1	70	4.53e-02
GO:BP	GO:0019319	hexose biosynthetic process	1	73	4.65e-02
GO:BP	GO:0030010	establishment of cell polarity	2	135	4.72e-02
GO:BP	GO:0006835	dicarboxylic acid transport	1	61	4.72e-02
GO:BP	GO:0051588	regulation of neurotransmitter transport	1	71	4.83e-02
GO:BP	GO:0051952	regulation of amine transport	1	56	4.84e-02
GO:BP	GO:0046364	monosaccharide biosynthetic process	1	82	4.90e-02
GO:BP	GO:0003333	amino acid transmembrane transport	1	70	4.91e-02
GO:BP	GO:0080135	regulation of cellular response to stress	3	585	5.05e-02
GO:BP	GO:0043409	negative regulation of MAPK cascade	2	145	5.14e-02
GO:BP	GO:0003097	renal water transport	1	7	5.14e-02
GO:BP	GO:0015837	amine transport	1	59	5.14e-02
GO:BP	GO:0042752	regulation of circadian rhythm	1	93	5.33e-02
GO:BP	GO:0007049	cell cycle	3	1515	5.42e-02
GO:BP	GO:0051101	regulation of DNA binding	1	102	5.53e-02
GO:BP	GO:0001654	eye development	3	273	5.66e-02
GO:BP	GO:0150063	visual system development	3	274	5.77e-02
GO:BP	GO:0048880	sensory system development	3	276	5.88e-02
GO:BP	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway	1	11	5.88e-02
GO:BP	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	1	8	5.88e-02
GO:BP	GO:0044092	negative regulation of molecular function	4	730	6.19e-02
GO:BP	GO:0035296	regulation of tube diameter	1	98	6.19e-02
GO:BP	GO:0097746	blood vessel diameter maintenance	1	98	6.19e-02
GO:BP	GO:0051549	positive regulation of keratinocyte migration	1	11	6.19e-02
GO:BP	GO:0035150	regulation of tube size	1	98	6.19e-02
GO:BP	GO:0006469	negative regulation of protein kinase activity	2	173	6.21e-02
GO:BP	GO:0006865	amino acid transport	1	103	6.21e-02
GO:BP	GO:1905039	carboxylic acid transmembrane transport	1	111	6.25e-02
GO:BP	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus	1	10	6.25e-02
GO:BP	GO:0030213	hyaluronan biosynthetic process	1	10	6.25e-02
GO:BP	GO:0035810	positive regulation of urine volume	1	10	6.25e-02
GO:BP	GO:0036302	atrioventricular canal development	1	12	6.25e-02
GO:BP	GO:0007179	transforming growth factor beta receptor signaling pathway	2	177	6.25e-02
GO:BP	GO:0070486	leukocyte aggregation	1	9	6.25e-02
GO:BP	GO:1903825	organic acid transmembrane transport	1	112	6.25e-02
GO:BP	GO:0051100	negative regulation of binding	1	133	6.32e-02
GO:BP	GO:0034085	establishment of sister chromatid cohesion	1	10	6.33e-02
GO:BP	GO:0050796	regulation of insulin secretion	1	119	6.54e-02
GO:BP	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	1	16	6.54e-02
GO:BP	GO:0010838	positive regulation of keratinocyte proliferation	1	9	6.54e-02
GO:BP	GO:0031396	regulation of protein ubiquitination	2	194	6.54e-02
GO:BP	GO:1901841	regulation of high voltage-gated calcium channel activity	1	12	6.54e-02
GO:BP	GO:0051547	regulation of keratinocyte migration	1	13	6.54e-02
GO:BP	GO:0033673	negative regulation of kinase activity	2	191	6.67e-02
GO:BP	GO:0035265	organ growth	2	128	6.71e-02
GO:BP	GO:0044849	estrous cycle	1	14	6.72e-02
GO:BP	GO:0001505	regulation of neurotransmitter levels	1	132	6.90e-02
GO:BP	GO:0006006	glucose metabolic process	1	153	6.97e-02
GO:BP	GO:0016051	carbohydrate biosynthetic process	2	160	6.99e-02
GO:BP	GO:1901201	regulation of extracellular matrix assembly	1	15	6.99e-02
GO:BP	GO:0007163	establishment or maintenance of cell polarity	2	197	7.06e-02
GO:BP	GO:0051240	positive regulation of multicellular organismal process	2	1103	7.06e-02
GO:BP	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	1	16	7.08e-02
GO:BP	GO:0098739	import across plasma membrane	1	130	7.12e-02
GO:BP	GO:0090276	regulation of peptide hormone secretion	1	135	7.12e-02
GO:BP	GO:0006836	neurotransmitter transport	1	141	7.12e-02
GO:BP	GO:0002791	regulation of peptide secretion	1	137	7.12e-02
GO:BP	GO:0030073	insulin secretion	1	144	7.12e-02
GO:BP	GO:0007623	circadian rhythm	1	160	7.12e-02
GO:BP	GO:0090087	regulation of peptide transport	1	139	7.15e-02
GO:BP	GO:0042592	homeostatic process	2	1189	7.33e-02
GO:BP	GO:0072330	monocarboxylic acid biosynthetic process	1	146	7.34e-02
GO:BP	GO:0060602	branch elongation of an epithelium	1	15	7.41e-02
GO:BP	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	1	13	7.41e-02
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	2	211	7.42e-02
GO:BP	GO:0055012	ventricular cardiac muscle cell differentiation	1	15	7.42e-02
GO:BP	GO:0051177	meiotic sister chromatid cohesion	1	11	7.42e-02
GO:BP	GO:0045444	fat cell differentiation	1	187	7.54e-02
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	2	222	7.54e-02
GO:BP	GO:0019318	hexose metabolic process	1	187	7.54e-02
GO:BP	GO:0051546	keratinocyte migration	1	15	7.54e-02
GO:BP	GO:0071498	cellular response to fluid shear stress	1	19	7.54e-02
GO:BP	GO:0042981	regulation of apoptotic process	5	1092	7.54e-02
GO:BP	GO:0051348	negative regulation of transferase activity	2	225	7.54e-02
GO:BP	GO:1901617	organic hydroxy compound biosynthetic process	1	174	7.54e-02
GO:BP	GO:1903320	regulation of protein modification by small protein conjugation or removal	2	232	7.54e-02
GO:BP	GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	1	14	7.54e-02
GO:BP	GO:0071559	response to transforming growth factor beta	2	227	7.61e-02
GO:BP	GO:1900746	regulation of vascular endothelial growth factor signaling pathway	1	18	7.61e-02
GO:BP	GO:0036120	cellular response to platelet-derived growth factor stimulus	1	20	7.61e-02
GO:BP	GO:0030072	peptide hormone secretion	1	169	7.61e-02
GO:BP	GO:1903522	regulation of blood circulation	1	197	7.61e-02
GO:BP	GO:0002790	peptide secretion	1	173	7.61e-02
GO:BP	GO:0035809	regulation of urine volume	1	14	7.61e-02
GO:BP	GO:1901386	negative regulation of voltage-gated calcium channel activity	1	14	7.61e-02
GO:BP	GO:0046883	regulation of hormone secretion	1	171	7.76e-02
GO:BP	GO:0005996	monosaccharide metabolic process	1	212	7.77e-02
GO:BP	GO:0071363	cellular response to growth factor stimulus	3	549	7.77e-02
GO:BP	GO:0003018	vascular process in circulatory system	1	198	7.77e-02
GO:BP	GO:0050708	regulation of protein secretion	1	186	7.77e-02
GO:BP	GO:0043067	regulation of programmed cell death	5	1124	7.77e-02
GO:BP	GO:0015833	peptide transport	1	182	7.81e-02
GO:BP	GO:0031399	regulation of protein modification process	4	1096	7.81e-02
GO:BP	GO:1902547	regulation of cellular response to vascular endothelial growth factor stimulus	1	20	7.83e-02
GO:BP	GO:0048011	neurotrophin TRK receptor signaling pathway	1	23	7.83e-02
GO:BP	GO:0036119	response to platelet-derived growth factor	1	22	7.83e-02
GO:BP	GO:0090162	establishment of epithelial cell polarity	1	30	7.91e-02
GO:BP	GO:0003417	growth plate cartilage development	1	14	8.01e-02
GO:BP	GO:1901798	positive regulation of signal transduction by p53 class mediator	1	28	8.02e-02
GO:BP	GO:0003091	renal water homeostasis	1	14	8.02e-02
GO:BP	GO:0070848	response to growth factor	3	571	8.31e-02
GO:BP	GO:0048511	rhythmic process	1	233	8.33e-02
GO:BP	GO:0043950	positive regulation of cAMP-mediated signaling	1	5	8.40e-02
GO:BP	GO:0009416	response to light stimulus	1	241	8.56e-02
GO:BP	GO:0070372	regulation of ERK1 and ERK2 cascade	2	192	8.56e-02
GO:BP	GO:0016567	protein ubiquitination	3	684	8.56e-02
GO:BP	GO:0046879	hormone secretion	1	212	8.56e-02
GO:BP	GO:0034260	negative regulation of GTPase activity	1	25	8.56e-02
GO:BP	GO:0060348	bone development	2	157	8.58e-02
GO:BP	GO:0060441	epithelial tube branching involved in lung morphogenesis	1	21	8.58e-02
GO:BP	GO:0021756	striatum development	1	18	8.58e-02
GO:BP	GO:0016053	organic acid biosynthetic process	1	224	8.58e-02
GO:BP	GO:0046394	carboxylic acid biosynthetic process	1	223	8.58e-02
GO:BP	GO:0009914	hormone transport	1	217	8.58e-02
GO:BP	GO:2000647	negative regulation of stem cell proliferation	1	18	8.58e-02
GO:BP	GO:1901873	regulation of post-translational protein modification	1	302	8.66e-02
GO:BP	GO:0003401	axis elongation	1	25	8.75e-02
GO:BP	GO:0015980	energy derivation by oxidation of organic compounds	1	288	8.75e-02
GO:BP	GO:0140013	meiotic nuclear division	2	117	8.80e-02
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	2	261	8.80e-02
GO:BP	GO:0006833	water transport	1	12	8.80e-02
GO:BP	GO:0015849	organic acid transport	1	214	8.80e-02
GO:BP	GO:0046942	carboxylic acid transport	1	213	8.80e-02
GO:BP	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	1	25	8.80e-02
GO:BP	GO:0009306	protein secretion	1	262	8.92e-02
GO:BP	GO:0051098	regulation of binding	1	314	8.92e-02
GO:BP	GO:0048705	skeletal system morphogenesis	2	155	8.92e-02
GO:BP	GO:0009967	positive regulation of signal transduction	4	1116	8.92e-02
GO:BP	GO:0042886	amide transport	1	237	8.92e-02
GO:BP	GO:0035592	establishment of protein localization to extracellular region	1	262	8.92e-02
GO:BP	GO:0007423	sensory organ development	3	395	8.92e-02
GO:BP	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	1	36	8.92e-02
GO:BP	GO:0070371	ERK1 and ERK2 cascade	2	211	8.92e-02
GO:BP	GO:0070293	renal absorption	1	24	8.92e-02
GO:BP	GO:0032331	negative regulation of chondrocyte differentiation	1	18	8.95e-02
GO:BP	GO:0071692	protein localization to extracellular region	1	266	8.98e-02
GO:BP	GO:0007130	synaptonemal complex assembly	1	10	9.09e-02
GO:BP	GO:0050767	regulation of neurogenesis	1	302	9.15e-02
GO:BP	GO:0050891	multicellular organismal-level water homeostasis	1	17	9.23e-02
GO:BP	GO:0060317	cardiac epithelial to mesenchymal transition	1	28	9.23e-02
GO:BP	GO:0030212	hyaluronan metabolic process	1	21	9.23e-02
GO:BP	GO:0006631	fatty acid metabolic process	1	276	9.31e-02
GO:BP	GO:0032446	protein modification by small protein conjugation	3	759	9.36e-02
GO:BP	GO:0034405	response to fluid shear stress	1	31	9.36e-02
GO:BP	GO:0000132	establishment of mitotic spindle orientation	1	32	9.36e-02
GO:BP	GO:1903046	meiotic cell cycle process	2	132	9.48e-02
GO:BP	GO:0021544	subpallium development	1	19	9.48e-02
GO:BP	GO:0035116	embryonic hindlimb morphogenesis	1	17	9.48e-02
GO:BP	GO:0003416	endochondral bone growth	1	22	9.48e-02
GO:BP	GO:0006417	regulation of translation	1	373	9.51e-02
GO:BP	GO:0038179	neurotrophin signaling pathway	1	36	9.51e-02
GO:BP	GO:0070193	synaptonemal complex organization	1	13	9.51e-02
GO:BP	GO:0090311	regulation of protein deacetylation	1	44	9.51e-02
GO:BP	GO:0043010	camera-type eye development	2	237	9.51e-02
GO:BP	GO:0009314	response to radiation	1	339	9.51e-02
GO:BP	GO:0032885	regulation of polysaccharide biosynthetic process	1	32	9.51e-02
GO:BP	GO:0015711	organic anion transport	1	270	9.66e-02
GO:BP	GO:0042044	fluid transport	1	19	9.94e-02
GO:BP	GO:0098868	bone growth	1	23	1.01e-01
GO:BP	GO:0061037	negative regulation of cartilage development	1	23	1.01e-01
GO:BP	GO:0014911	positive regulation of smooth muscle cell migration	1	32	1.01e-01
GO:BP	GO:0051960	regulation of nervous system development	1	357	1.01e-01
GO:BP	GO:0040001	establishment of mitotic spindle localization	1	37	1.01e-01
GO:BP	GO:0038084	vascular endothelial growth factor signaling pathway	1	35	1.01e-01
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	2	298	1.02e-01
GO:BP	GO:0051294	establishment of spindle orientation	1	37	1.02e-01
GO:BP	GO:0034248	regulation of amide metabolic process	1	426	1.02e-01
GO:BP	GO:0048566	embryonic digestive tract development	1	20	1.03e-01
GO:BP	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	1	28	1.03e-01
GO:BP	GO:0023061	signal release	1	329	1.03e-01
GO:BP	GO:0045596	negative regulation of cell differentiation	3	471	1.03e-01
GO:BP	GO:0048384	retinoic acid receptor signaling pathway	1	27	1.03e-01
GO:BP	GO:0032881	regulation of polysaccharide metabolic process	1	35	1.03e-01
GO:BP	GO:0085029	extracellular matrix assembly	1	36	1.03e-01
GO:BP	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	1	37	1.03e-01
GO:BP	GO:0060351	cartilage development involved in endochondral bone morphogenesis	1	25	1.04e-01
GO:BP	GO:0008015	blood circulation	1	372	1.04e-01
GO:BP	GO:0090066	regulation of anatomical structure size	1	395	1.05e-01
GO:BP	GO:0051223	regulation of protein transport	1	404	1.05e-01
GO:BP	GO:0006091	generation of precursor metabolites and energy	1	423	1.05e-01
GO:BP	GO:0048048	embryonic eye morphogenesis	1	25	1.05e-01
GO:BP	GO:1902531	regulation of intracellular signal transduction	4	1318	1.06e-01
GO:BP	GO:0002068	glandular epithelial cell development	1	28	1.06e-01
GO:BP	GO:0035137	hindlimb morphogenesis	1	21	1.06e-01
GO:BP	GO:0010837	regulation of keratinocyte proliferation	1	33	1.06e-01
GO:BP	GO:0090596	sensory organ morphogenesis	2	179	1.06e-01
GO:BP	GO:0006915	apoptotic process	3	1452	1.08e-01
GO:BP	GO:0046580	negative regulation of Ras protein signal transduction	1	46	1.08e-01
GO:BP	GO:0070201	regulation of establishment of protein localization	1	428	1.08e-01
GO:BP	GO:0010817	regulation of hormone levels	1	337	1.08e-01
GO:BP	GO:1901385	regulation of voltage-gated calcium channel activity	1	29	1.08e-01
GO:BP	GO:0044057	regulation of system process	1	398	1.08e-01
GO:BP	GO:0023056	positive regulation of signaling	4	1252	1.09e-01
GO:BP	GO:0010647	positive regulation of cell communication	4	1249	1.09e-01
GO:BP	GO:1901615	organic hydroxy compound metabolic process	1	375	1.09e-01
GO:BP	GO:0043949	regulation of cAMP-mediated signaling	1	17	1.09e-01
GO:BP	GO:1903530	regulation of secretion by cell	1	382	1.09e-01
GO:BP	GO:0060425	lung morphogenesis	1	39	1.10e-01
GO:BP	GO:0005975	carbohydrate metabolic process	1	439	1.10e-01
GO:BP	GO:0048562	embryonic organ morphogenesis	2	186	1.10e-01
GO:BP	GO:0030855	epithelial cell differentiation	3	439	1.10e-01
GO:BP	GO:0040020	regulation of meiotic nuclear division	1	19	1.11e-01
GO:BP	GO:0044283	small molecule biosynthetic process	1	432	1.11e-01
GO:BP	GO:2001258	negative regulation of cation channel activity	1	31	1.11e-01
GO:BP	GO:0003013	circulatory system process	1	445	1.11e-01
GO:BP	GO:0001932	regulation of protein phosphorylation	3	758	1.11e-01
GO:BP	GO:0034762	regulation of transmembrane transport	1	392	1.11e-01
GO:BP	GO:0012501	programmed cell death	3	1498	1.12e-01
GO:BP	GO:0070647	protein modification by small protein conjugation or removal	3	870	1.12e-01
GO:BP	GO:0008219	cell death	3	1504	1.12e-01
GO:BP	GO:0051058	negative regulation of small GTPase mediated signal transduction	1	52	1.14e-01
GO:BP	GO:0051046	regulation of secretion	1	413	1.14e-01
GO:BP	GO:1903170	negative regulation of calcium ion transmembrane transport	1	35	1.14e-01
GO:BP	GO:0032787	monocarboxylic acid metabolic process	1	434	1.14e-01
GO:BP	GO:0043407	negative regulation of MAP kinase activity	1	50	1.14e-01
GO:BP	GO:0001822	kidney development	2	246	1.16e-01
GO:BP	GO:0051293	establishment of spindle localization	1	49	1.18e-01
GO:BP	GO:0051239	regulation of multicellular organismal process	2	2052	1.18e-01
GO:BP	GO:0006338	chromatin remodeling	1	520	1.18e-01
GO:BP	GO:0031641	regulation of myelination	1	35	1.19e-01
GO:BP	GO:0072001	renal system development	2	253	1.20e-01
GO:BP	GO:1903053	regulation of extracellular matrix organization	1	47	1.20e-01
GO:BP	GO:0043616	keratinocyte proliferation	1	39	1.20e-01
GO:BP	GO:0035924	cellular response to vascular endothelial growth factor stimulus	1	54	1.21e-01
GO:BP	GO:0030330	DNA damage response, signal transduction by p53 class mediator	1	70	1.22e-01
GO:BP	GO:0023051	regulation of signaling	3	2560	1.22e-01
GO:BP	GO:0010646	regulation of cell communication	3	2567	1.23e-01
GO:BP	GO:0051653	spindle localization	1	53	1.23e-01
GO:BP	GO:0051321	meiotic cell cycle	2	183	1.24e-01
GO:BP	GO:1900024	regulation of substrate adhesion-dependent cell spreading	1	54	1.25e-01
GO:BP	GO:0002066	columnar/cuboidal epithelial cell development	1	39	1.30e-01
GO:BP	GO:0006476	protein deacetylation	1	81	1.31e-01
GO:BP	GO:0042325	regulation of phosphorylation	3	841	1.31e-01
GO:BP	GO:0006412	translation	1	657	1.32e-01
GO:BP	GO:0014910	regulation of smooth muscle cell migration	1	57	1.33e-01
GO:BP	GO:0032330	regulation of chondrocyte differentiation	1	36	1.33e-01
GO:BP	GO:0080134	regulation of response to stress	2	1074	1.34e-01
GO:BP	GO:0043043	peptide biosynthetic process	1	677	1.35e-01
GO:BP	GO:0006325	chromatin organization	1	631	1.35e-01
GO:BP	GO:0032940	secretion by cell	1	573	1.39e-01
GO:BP	GO:2000026	regulation of multicellular organismal development	4	997	1.39e-01
GO:BP	GO:0051926	negative regulation of calcium ion transport	1	45	1.39e-01
GO:BP	GO:0006024	glycosaminoglycan biosynthetic process	1	59	1.40e-01
GO:BP	GO:0060284	regulation of cell development	1	593	1.41e-01
GO:BP	GO:0007129	homologous chromosome pairing at meiosis	1	24	1.41e-01
GO:BP	GO:0042698	ovulation cycle	1	54	1.41e-01
GO:BP	GO:0006023	aminoglycan biosynthetic process	1	61	1.41e-01
GO:BP	GO:0014909	smooth muscle cell migration	1	64	1.41e-01
GO:BP	GO:0035601	protein deacylation	1	91	1.41e-01
GO:BP	GO:0008543	fibroblast growth factor receptor signaling pathway	1	59	1.42e-01
GO:BP	GO:0098732	macromolecule deacylation	1	92	1.42e-01
GO:BP	GO:0140962	multicellular organismal-level chemical homeostasis	1	48	1.42e-01
GO:BP	GO:0008285	negative regulation of cell population proliferation	1	643	1.42e-01
GO:BP	GO:0060350	endochondral bone morphogenesis	1	47	1.43e-01
GO:BP	GO:0071824	protein-DNA complex organization	1	711	1.43e-01
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	2	445	1.43e-01
GO:BP	GO:0032880	regulation of protein localization	1	719	1.43e-01
GO:BP	GO:0140352	export from cell	1	617	1.43e-01
GO:BP	GO:0007062	sister chromatid cohesion	1	52	1.43e-01
GO:BP	GO:0045913	positive regulation of carbohydrate metabolic process	1	61	1.44e-01
GO:BP	GO:0006518	peptide metabolic process	1	781	1.47e-01
GO:BP	GO:0043604	amide biosynthetic process	1	785	1.49e-01
GO:BP	GO:0071495	cellular response to endogenous stimulus	4	1097	1.49e-01
GO:BP	GO:0098657	import into cell	1	664	1.50e-01
GO:BP	GO:0032413	negative regulation of ion transmembrane transporter activity	1	52	1.50e-01
GO:BP	GO:0019752	carboxylic acid metabolic process	1	684	1.50e-01
GO:BP	GO:1901796	regulation of signal transduction by p53 class mediator	1	102	1.50e-01
GO:BP	GO:0046903	secretion	1	647	1.51e-01
GO:BP	GO:0006082	organic acid metabolic process	1	703	1.52e-01
GO:BP	GO:0043436	oxoacid metabolic process	1	699	1.52e-01
GO:BP	GO:0001570	vasculogenesis	1	67	1.52e-01
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	1	744	1.52e-01
GO:BP	GO:0019933	cAMP-mediated signaling	1	35	1.52e-01
GO:BP	GO:0060341	regulation of cellular localization	1	805	1.53e-01
GO:BP	GO:0014812	muscle cell migration	1	75	1.55e-01
GO:BP	GO:0045143	homologous chromosome segregation	1	32	1.55e-01
GO:BP	GO:0044255	cellular lipid metabolic process	1	736	1.55e-01
GO:BP	GO:0051174	regulation of phosphorus metabolic process	3	950	1.55e-01
GO:BP	GO:0019220	regulation of phosphate metabolic process	3	949	1.55e-01
GO:BP	GO:0006950	response to stress	3	2763	1.55e-01
GO:BP	GO:0070192	chromosome organization involved in meiotic cell cycle	1	35	1.55e-01
GO:BP	GO:0032410	negative regulation of transporter activity	1	59	1.58e-01
GO:BP	GO:0061035	regulation of cartilage development	1	53	1.58e-01
GO:BP	GO:0043687	post-translational protein modification	3	1102	1.58e-01
GO:BP	GO:0051093	negative regulation of developmental process	3	654	1.58e-01
GO:BP	GO:0033554	cellular response to stress	4	1662	1.59e-01
GO:BP	GO:0051480	regulation of cytosolic calcium ion concentration	1	39	1.59e-01
GO:BP	GO:0009893	positive regulation of metabolic process	2	2846	1.59e-01
GO:BP	GO:0016525	negative regulation of angiogenesis	1	71	1.59e-01
GO:BP	GO:0007264	small GTPase mediated signal transduction	2	413	1.59e-01
GO:BP	GO:0002067	glandular epithelial cell differentiation	1	49	1.59e-01
GO:BP	GO:0030335	positive regulation of cell migration	2	408	1.59e-01
GO:BP	GO:2000181	negative regulation of blood vessel morphogenesis	1	72	1.60e-01
GO:BP	GO:0090288	negative regulation of cellular response to growth factor stimulus	1	80	1.60e-01
GO:BP	GO:1901343	negative regulation of vasculature development	1	72	1.60e-01
GO:BP	GO:0010608	post-transcriptional regulation of gene expression	1	475	1.60e-01
GO:BP	GO:0009628	response to abiotic stimulus	1	848	1.61e-01
GO:BP	GO:0051445	regulation of meiotic cell cycle	1	45	1.61e-01
GO:BP	GO:1904063	negative regulation of cation transmembrane transport	1	64	1.61e-01
GO:BP	GO:1990823	response to leukemia inhibitory factor	1	87	1.61e-01
GO:BP	GO:1990830	cellular response to leukemia inhibitory factor	1	86	1.61e-01
GO:BP	GO:1903510	mucopolysaccharide metabolic process	1	75	1.61e-01
GO:BP	GO:0071901	negative regulation of protein serine/threonine kinase activity	1	96	1.63e-01
GO:BP	GO:0045859	regulation of protein kinase activity	2	473	1.63e-01
GO:BP	GO:0044344	cellular response to fibroblast growth factor stimulus	1	81	1.63e-01
GO:BP	GO:0033138	positive regulation of peptidyl-serine phosphorylation	1	68	1.63e-01
GO:BP	GO:0042472	inner ear morphogenesis	1	59	1.63e-01
GO:BP	GO:0043255	regulation of carbohydrate biosynthetic process	1	79	1.63e-01
GO:BP	GO:0045595	regulation of cell differentiation	4	1122	1.64e-01
GO:BP	GO:2000147	positive regulation of cell motility	2	421	1.64e-01
GO:BP	GO:0034446	substrate adhesion-dependent cell spreading	1	90	1.64e-01
GO:BP	GO:0043086	negative regulation of catalytic activity	2	456	1.64e-01
GO:BP	GO:0035556	intracellular signal transduction	5	2036	1.65e-01
GO:BP	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	1	78	1.65e-01
GO:BP	GO:1901019	regulation of calcium ion transmembrane transporter activity	1	70	1.67e-01
GO:BP	GO:0071774	response to fibroblast growth factor	1	85	1.69e-01
GO:BP	GO:0043603	amide metabolic process	1	1003	1.69e-01
GO:BP	GO:0034766	negative regulation of monoatomic ion transmembrane transport	1	70	1.69e-01
GO:BP	GO:0040017	positive regulation of locomotion	2	429	1.69e-01
GO:BP	GO:0048584	positive regulation of response to stimulus	4	1557	1.69e-01
GO:BP	GO:0048568	embryonic organ development	2	314	1.69e-01
GO:BP	GO:0071347	cellular response to interleukin-1	1	64	1.69e-01
GO:BP	GO:0072091	regulation of stem cell proliferation	1	58	1.74e-01
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	1	1005	1.80e-01
GO:BP	GO:0048869	cellular developmental process	3	2943	1.81e-01
GO:BP	GO:0030154	cell differentiation	3	2942	1.81e-01
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	1	1014	1.81e-01
GO:BP	GO:0030203	glycosaminoglycan metabolic process	1	87	1.81e-01
GO:BP	GO:0045132	meiotic chromosome segregation	1	51	1.83e-01
GO:BP	GO:0042471	ear morphogenesis	1	73	1.84e-01
GO:BP	GO:0048514	blood vessel morphogenesis	2	461	1.86e-01
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	5	1832	1.88e-01
GO:BP	GO:0003014	renal system process	1	76	1.89e-01
GO:BP	GO:0006629	lipid metabolic process	1	989	1.89e-01
GO:BP	GO:0009887	animal organ morphogenesis	3	725	1.90e-01
GO:BP	GO:0010811	positive regulation of cell-substrate adhesion	1	99	1.90e-01
GO:BP	GO:0001657	ureteric bud development	1	75	1.90e-01
GO:BP	GO:0006022	aminoglycan metabolic process	1	92	1.90e-01
GO:BP	GO:0072163	mesonephric epithelium development	1	76	1.91e-01
GO:BP	GO:0051253	negative regulation of RNA metabolic process	1	1112	1.91e-01
GO:BP	GO:0072164	mesonephric tubule development	1	76	1.91e-01
GO:BP	GO:0009719	response to endogenous stimulus	4	1260	1.92e-01
GO:BP	GO:0033135	regulation of peptidyl-serine phosphorylation	1	97	1.92e-01
GO:BP	GO:0043549	regulation of kinase activity	2	548	1.92e-01
GO:BP	GO:0019935	cyclic-nucleotide-mediated signaling	1	52	1.92e-01
GO:BP	GO:0001823	mesonephros development	1	77	1.96e-01
GO:BP	GO:0070555	response to interleukin-1	1	82	1.97e-01
GO:BP	GO:0051246	regulation of protein metabolic process	4	1895	1.98e-01
GO:BP	GO:0006468	protein phosphorylation	3	1130	1.98e-01
GO:BP	GO:0035295	tube development	3	822	1.98e-01
GO:BP	GO:0001501	skeletal system development	2	361	1.98e-01
GO:BP	GO:0000280	nuclear division	2	343	1.98e-01
GO:BP	GO:1901137	carbohydrate derivative biosynthetic process	2	544	1.98e-01
GO:BP	GO:0072331	signal transduction by p53 class mediator	1	163	1.98e-01
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	1	1203	2.00e-01
GO:BP	GO:0043271	negative regulation of monoatomic ion transport	1	88	2.00e-01
GO:BP	GO:0034763	negative regulation of transmembrane transport	1	96	2.00e-01
GO:BP	GO:0036211	protein modification process	5	2751	2.01e-01
GO:BP	GO:0051241	negative regulation of multicellular organismal process	3	744	2.01e-01
GO:BP	GO:0055085	transmembrane transport	1	1014	2.01e-01
GO:BP	GO:0048754	branching morphogenesis of an epithelial tube	1	121	2.06e-01
GO:BP	GO:0055007	cardiac muscle cell differentiation	1	108	2.06e-01
GO:BP	GO:0072359	circulatory system development	3	888	2.07e-01
GO:BP	GO:0042770	signal transduction in response to DNA damage	1	180	2.08e-01
GO:BP	GO:0002062	chondrocyte differentiation	1	89	2.08e-01
GO:BP	GO:0072089	stem cell proliferation	1	84	2.11e-01
GO:BP	GO:0007605	sensory perception of sound	1	97	2.11e-01
GO:BP	GO:0010634	positive regulation of epithelial cell migration	1	132	2.11e-01
GO:BP	GO:0007267	cell-cell signaling	1	1150	2.11e-01
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	1	80	2.11e-01
GO:BP	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	1	123	2.11e-01
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	1	1298	2.11e-01
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	1	1305	2.11e-01
GO:BP	GO:0022008	neurogenesis	1	1297	2.11e-01
GO:BP	GO:0001568	blood vessel development	2	537	2.12e-01
GO:BP	GO:0035113	embryonic appendage morphogenesis	1	89	2.13e-01
GO:BP	GO:2001257	regulation of cation channel activity	1	100	2.13e-01
GO:BP	GO:0030326	embryonic limb morphogenesis	1	89	2.13e-01
GO:BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	1	157	2.14e-01
GO:BP	GO:0051049	regulation of transport	1	1268	2.15e-01
GO:BP	GO:0009101	glycoprotein biosynthetic process	1	251	2.17e-01
GO:BP	GO:0034502	protein localization to chromosome	1	101	2.19e-01
GO:BP	GO:1901566	organonitrogen compound biosynthetic process	1	1496	2.20e-01
GO:BP	GO:0048285	organelle fission	2	387	2.20e-01
GO:BP	GO:0015031	protein transport	1	1366	2.20e-01
GO:BP	GO:0001944	vasculature development	2	562	2.21e-01
GO:BP	GO:0044281	small molecule metabolic process	1	1386	2.22e-01
GO:BP	GO:0051254	positive regulation of RNA metabolic process	1	1425	2.22e-01
GO:BP	GO:0007507	heart development	2	512	2.24e-01
GO:BP	GO:0043405	regulation of MAP kinase activity	1	141	2.24e-01
GO:BP	GO:0048565	digestive tract development	1	92	2.26e-01
GO:BP	GO:0050954	sensory perception of mechanical stimulus	1	111	2.26e-01
GO:BP	GO:0046578	regulation of Ras protein signal transduction	1	156	2.26e-01
GO:BP	GO:0045184	establishment of protein localization	1	1468	2.27e-01
GO:BP	GO:0031345	negative regulation of cell projection organization	1	154	2.27e-01
GO:BP	GO:0030324	lung development	1	144	2.27e-01
GO:BP	GO:0007127	meiosis I	1	73	2.27e-01
GO:BP	GO:0061138	morphogenesis of a branching epithelium	1	143	2.27e-01
GO:BP	GO:0043412	macromolecule modification	5	2948	2.29e-01
GO:BP	GO:0051338	regulation of transferase activity	2	664	2.29e-01
GO:BP	GO:0030323	respiratory tube development	1	148	2.29e-01
GO:BP	GO:0048598	embryonic morphogenesis	2	438	2.31e-01
GO:BP	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	1	144	2.32e-01
GO:BP	GO:0061982	meiosis I cell cycle process	1	77	2.34e-01
GO:BP	GO:0042552	myelination	1	114	2.35e-01
GO:BP	GO:0055123	digestive system development	1	100	2.36e-01
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	1	1589	2.36e-01
GO:BP	GO:0007272	ensheathment of neurons	1	116	2.36e-01
GO:BP	GO:0060429	epithelium development	3	849	2.36e-01
GO:BP	GO:0008366	axon ensheathment	1	116	2.36e-01
GO:BP	GO:0048839	inner ear development	1	129	2.36e-01
GO:BP	GO:0006109	regulation of carbohydrate metabolic process	1	147	2.36e-01
GO:BP	GO:0035051	cardiocyte differentiation	1	134	2.36e-01
GO:BP	GO:0001763	morphogenesis of a branching structure	1	155	2.37e-01
GO:BP	GO:0035108	limb morphogenesis	1	113	2.37e-01
GO:BP	GO:0035107	appendage morphogenesis	1	113	2.37e-01
GO:BP	GO:0072073	kidney epithelium development	1	113	2.40e-01
GO:BP	GO:0032879	regulation of localization	1	1570	2.41e-01
GO:BP	GO:0016310	phosphorylation	3	1338	2.41e-01
GO:BP	GO:0070374	positive regulation of ERK1 and ERK2 cascade	1	120	2.42e-01
GO:BP	GO:0060541	respiratory system development	1	161	2.42e-01
GO:BP	GO:0035264	multicellular organism growth	1	124	2.42e-01
GO:BP	GO:0065009	regulation of molecular function	2	1905	2.43e-01
GO:BP	GO:0008033	tRNA processing	1	131	2.43e-01
GO:BP	GO:1903169	regulation of calcium ion transmembrane transport	1	120	2.43e-01
GO:BP	GO:0009100	glycoprotein metabolic process	1	315	2.44e-01
GO:BP	GO:0048589	developmental growth	2	522	2.44e-01
GO:BP	GO:0042127	regulation of cell population proliferation	1	1568	2.44e-01
GO:BP	GO:0071345	cellular response to cytokine stimulus	2	544	2.45e-01
GO:BP	GO:0003008	system process	1	1194	2.51e-01
GO:BP	GO:0050679	positive regulation of epithelial cell proliferation	1	152	2.52e-01
GO:BP	GO:0071705	nitrogen compound transport	1	1689	2.53e-01
GO:BP	GO:0009888	tissue development	4	1425	2.54e-01
GO:BP	GO:0043583	ear development	1	150	2.55e-01
GO:BP	GO:0061351	neural precursor cell proliferation	1	122	2.55e-01
GO:BP	GO:0048592	eye morphogenesis	1	114	2.55e-01
GO:BP	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	1	71	2.56e-01
GO:BP	GO:0010810	regulation of cell-substrate adhesion	1	171	2.58e-01
GO:BP	GO:0051783	regulation of nuclear division	1	115	2.60e-01
GO:BP	GO:0051649	establishment of localization in cell	1	1842	2.60e-01
GO:BP	GO:0035239	tube morphogenesis	2	663	2.60e-01
GO:BP	GO:0048522	positive regulation of cellular process	2	4197	2.60e-01
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	1	1764	2.61e-01
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	2	741	2.64e-01
GO:BP	GO:0050793	regulation of developmental process	1	1813	2.66e-01
GO:BP	GO:0060560	developmental growth involved in morphogenesis	1	207	2.68e-01
GO:BP	GO:0010632	regulation of epithelial cell migration	1	195	2.68e-01
GO:BP	GO:0071356	cellular response to tumor necrosis factor	1	159	2.69e-01
GO:BP	GO:0007399	nervous system development	1	1886	2.69e-01
GO:BP	GO:0006366	transcription by RNA polymerase II	1	1852	2.70e-01
GO:BP	GO:0048736	appendage development	1	141	2.72e-01
GO:BP	GO:0060173	limb development	1	141	2.72e-01
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	1	1896	2.76e-01
GO:BP	GO:0034097	response to cytokine	2	609	2.77e-01
GO:BP	GO:0009755	hormone-mediated signaling pathway	1	142	2.82e-01
GO:BP	GO:0030334	regulation of cell migration	2	707	2.82e-01
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	1	1958	2.83e-01
GO:BP	GO:0009605	response to external stimulus	1	1635	2.83e-01
GO:BP	GO:0009891	positive regulation of biosynthetic process	1	1972	2.85e-01
GO:BP	GO:0034612	response to tumor necrosis factor	1	176	2.85e-01
GO:BP	GO:0008104	protein localization	1	2128	2.86e-01
GO:BP	GO:0070727	cellular macromolecule localization	1	2137	2.87e-01
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	1	1669	2.87e-01
GO:BP	GO:0048468	cell development	1	1950	2.88e-01
GO:BP	GO:0009966	regulation of signal transduction	4	2271	2.90e-01
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	1	1708	2.91e-01
GO:BP	GO:0045765	regulation of angiogenesis	1	200	2.91e-01
GO:BP	GO:0051216	cartilage development	1	149	2.91e-01
GO:BP	GO:0009890	negative regulation of biosynthetic process	1	1721	2.91e-01
GO:BP	GO:1901342	regulation of vasculature development	1	202	2.92e-01
GO:BP	GO:0003007	heart morphogenesis	1	217	2.92e-01
GO:BP	GO:0045165	cell fate commitment	1	157	2.94e-01
GO:BP	GO:0002064	epithelial cell development	1	156	2.95e-01
GO:BP	GO:0048518	positive regulation of biological process	2	4566	2.95e-01
GO:BP	GO:1903039	positive regulation of leukocyte cell-cell adhesion	1	157	2.95e-01
GO:BP	GO:0018193	peptidyl-amino acid modification	2	866	2.98e-01
GO:BP	GO:0065008	regulation of biological quality	1	2085	2.98e-01
GO:BP	GO:2000145	regulation of cell motility	2	741	2.98e-01
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	1	249	3.00e-01
GO:BP	GO:0051924	regulation of calcium ion transport	1	167	3.02e-01
GO:BP	GO:0023052	signaling	2	4134	3.05e-01
GO:BP	GO:0018105	peptidyl-serine phosphorylation	1	242	3.06e-01
GO:BP	GO:0032502	developmental process	2	4445	3.06e-01
GO:BP	GO:0071702	organic substance transport	1	2133	3.06e-01
GO:BP	GO:0048738	cardiac muscle tissue development	1	202	3.06e-01
GO:BP	GO:0006399	tRNA metabolic process	1	189	3.06e-01
GO:BP	GO:0051346	negative regulation of hydrolase activity	1	206	3.07e-01
GO:BP	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	1	189	3.07e-01
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	1	2367	3.07e-01
GO:BP	GO:0007154	cell communication	2	4210	3.10e-01
GO:BP	GO:0040012	regulation of locomotion	2	762	3.10e-01
GO:BP	GO:0018209	peptidyl-serine modification	1	254	3.17e-01
GO:BP	GO:0022898	regulation of transmembrane transporter activity	1	200	3.17e-01
GO:BP	GO:0022402	cell cycle process	3	1078	3.17e-01
GO:BP	GO:0014706	striated muscle tissue development	1	214	3.17e-01
GO:BP	GO:0031324	negative regulation of cellular metabolic process	1	2069	3.17e-01
GO:BP	GO:0019538	protein metabolic process	6	4202	3.17e-01
GO:BP	GO:1901135	carbohydrate derivative metabolic process	2	841	3.17e-01
GO:BP	GO:0008283	cell population proliferation	1	2340	3.17e-01
GO:BP	GO:0033036	macromolecule localization	1	2448	3.17e-01
GO:BP	GO:0010631	epithelial cell migration	1	253	3.17e-01
GO:BP	GO:2000241	regulation of reproductive process	1	126	3.19e-01
GO:BP	GO:0090132	epithelium migration	1	253	3.19e-01
GO:BP	GO:0007265	Ras protein signal transduction	1	287	3.20e-01
GO:BP	GO:0060562	epithelial tube morphogenesis	1	276	3.20e-01
GO:BP	GO:0090130	tissue migration	1	257	3.23e-01
GO:BP	GO:0022409	positive regulation of cell-cell adhesion	1	188	3.23e-01
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	1	2131	3.24e-01
GO:BP	GO:0032409	regulation of transporter activity	1	212	3.26e-01
GO:BP	GO:0030198	extracellular matrix organization	1	233	3.27e-01
GO:BP	GO:0043062	extracellular structure organization	1	234	3.27e-01
GO:BP	GO:0071900	regulation of protein serine/threonine kinase activity	1	274	3.27e-01
GO:BP	GO:0045229	external encapsulating structure organization	1	234	3.27e-01
GO:BP	GO:0031325	positive regulation of cellular metabolic process	1	2518	3.27e-01
GO:BP	GO:0006355	regulation of DNA-templated transcription	1	2560	3.30e-01
GO:BP	GO:2001141	regulation of RNA biosynthetic process	1	2577	3.31e-01
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	1	2607	3.33e-01
GO:BP	GO:0043087	regulation of GTPase activity	1	288	3.33e-01
GO:BP	GO:0009892	negative regulation of metabolic process	1	2297	3.39e-01
GO:BP	GO:0006351	DNA-templated transcription	1	2669	3.39e-01
GO:BP	GO:0032774	RNA biosynthetic process	1	2699	3.42e-01
GO:BP	GO:0031589	cell-substrate adhesion	1	271	3.45e-01
GO:BP	GO:0021537	telencephalon development	1	208	3.45e-01
GO:BP	GO:0051641	cellular localization	1	2822	3.45e-01
GO:BP	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	1	113	3.47e-01
GO:BP	GO:0061448	connective tissue development	1	212	3.49e-01
GO:BP	GO:0009968	negative regulation of signal transduction	2	1017	3.50e-01
GO:BP	GO:0040007	growth	2	737	3.50e-01
GO:BP	GO:0051146	striated muscle cell differentiation	1	239	3.50e-01
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	1	232	3.51e-01
GO:BP	GO:0051252	regulation of RNA metabolic process	1	2824	3.51e-01
GO:BP	GO:0050678	regulation of epithelial cell proliferation	1	268	3.53e-01
GO:BP	GO:1903037	regulation of leukocyte cell-cell adhesion	1	210	3.53e-01
GO:BP	GO:0050878	regulation of body fluid levels	1	237	3.53e-01
GO:BP	GO:0019222	regulation of metabolic process	2	4998	3.64e-01
GO:BP	GO:0048731	system development	1	2886	3.67e-01
GO:BP	GO:0070588	calcium ion transmembrane transport	1	221	3.68e-01
GO:BP	GO:0040011	locomotion	2	854	3.72e-01
GO:BP	GO:0043933	protein-containing complex organization	1	1964	3.72e-01
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	1	3054	3.72e-01
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	1	3059	3.72e-01
GO:BP	GO:0018130	heterocycle biosynthetic process	1	3115	3.77e-01
GO:BP	GO:0019438	aromatic compound biosynthetic process	1	3116	3.77e-01
GO:BP	GO:0007159	leukocyte cell-cell adhesion	1	233	3.77e-01
GO:BP	GO:1901564	organonitrogen compound metabolic process	7	4919	3.79e-01
GO:BP	GO:0010648	negative regulation of cell communication	2	1088	3.83e-01
GO:BP	GO:0023057	negative regulation of signaling	2	1090	3.83e-01
GO:BP	GO:0098813	nuclear chromosome segregation	1	264	3.86e-01
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	1	3221	3.87e-01
GO:BP	GO:0030522	intracellular receptor signaling pathway	1	256	3.91e-01
GO:BP	GO:0032501	multicellular organismal process	2	4807	3.91e-01
GO:BP	GO:0051656	establishment of organelle localization	1	397	3.93e-01
GO:BP	GO:0001667	ameboidal-type cell migration	1	358	3.93e-01
GO:BP	GO:0019932	second-messenger-mediated signaling	1	182	3.94e-01
GO:BP	GO:0010959	regulation of metal ion transport	1	271	3.95e-01
GO:BP	GO:0022414	reproductive process	3	924	3.99e-01
GO:BP	GO:0048583	regulation of response to stimulus	2	2877	3.99e-01
GO:BP	GO:0050673	epithelial cell proliferation	1	318	3.99e-01
GO:BP	GO:0000003	reproduction	3	933	4.02e-01
GO:BP	GO:0007275	multicellular organism development	1	3355	4.13e-01
GO:BP	GO:0006874	intracellular calcium ion homeostasis	1	208	4.13e-01
GO:BP	GO:0051051	negative regulation of transport	1	317	4.16e-01
GO:BP	GO:0022407	regulation of cell-cell adhesion	1	292	4.19e-01
GO:BP	GO:0045785	positive regulation of cell adhesion	1	319	4.19e-01
GO:BP	GO:0006810	transport	1	3294	4.19e-01
GO:BP	GO:0002009	morphogenesis of an epithelium	1	415	4.24e-01
GO:BP	GO:0001525	angiogenesis	1	389	4.24e-01
GO:BP	GO:0009790	embryo development	2	859	4.24e-01
GO:BP	GO:0042692	muscle cell differentiation	1	329	4.24e-01
GO:BP	GO:0006816	calcium ion transport	1	275	4.24e-01
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	1	3743	4.28e-01
GO:BP	GO:0055074	calcium ion homeostasis	1	221	4.31e-01
GO:BP	GO:0051234	establishment of localization	1	3453	4.31e-01
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	6	4243	4.35e-01
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	1	296	4.35e-01
GO:BP	GO:0060537	muscle tissue development	1	347	4.41e-01
GO:BP	GO:0030900	forebrain development	1	290	4.42e-01
GO:BP	GO:0006796	phosphate-containing compound metabolic process	3	2096	4.46e-01
GO:BP	GO:0016477	cell migration	2	1065	4.50e-01
GO:BP	GO:0006793	phosphorus metabolic process	3	2118	4.52e-01
GO:BP	GO:0071310	cellular response to organic substance	3	1390	4.53e-01
GO:BP	GO:0048585	negative regulation of response to stimulus	2	1267	4.58e-01
GO:BP	GO:0048878	chemical homeostasis	2	689	4.58e-01
GO:BP	GO:0007059	chromosome segregation	1	360	4.58e-01
GO:BP	GO:0051640	organelle localization	1	521	4.61e-01
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	1	470	4.67e-01
GO:BP	GO:0080090	regulation of primary metabolic process	6	4371	4.69e-01
GO:BP	GO:0010468	regulation of gene expression	1	3587	4.73e-01
GO:BP	GO:0048523	negative regulation of cellular process	1	3773	4.73e-01
GO:BP	GO:0048729	tissue morphogenesis	1	501	4.75e-01
GO:BP	GO:0051179	localization	1	3983	4.75e-01
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	1	3702	4.81e-01
GO:BP	GO:0031344	regulation of cell projection organization	1	542	4.85e-01
GO:BP	GO:0000226	microtubule cytoskeleton organization	1	549	4.85e-01
GO:BP	GO:0019953	sexual reproduction	2	633	4.85e-01
GO:BP	GO:0001934	positive regulation of protein phosphorylation	1	465	4.89e-01
GO:BP	GO:0031326	regulation of cellular biosynthetic process	1	3794	4.89e-01
GO:BP	GO:0034470	ncRNA processing	1	397	4.89e-01
GO:BP	GO:0009889	regulation of biosynthetic process	1	3820	4.90e-01
GO:BP	GO:0048856	anatomical structure development	1	4100	4.95e-01
GO:BP	GO:0050790	regulation of catalytic activity	1	1349	4.95e-01
GO:BP	GO:0043269	regulation of monoatomic ion transport	1	369	4.97e-01
GO:BP	GO:0050896	response to stimulus	2	5721	4.97e-01
GO:BP	GO:0048519	negative regulation of biological process	1	4026	4.97e-01
GO:BP	GO:0051129	negative regulation of cellular component organization	1	592	5.08e-01
GO:BP	GO:0048870	cell motility	2	1169	5.08e-01
GO:BP	GO:0048513	animal organ development	4	2156	5.11e-01
GO:BP	GO:0042327	positive regulation of phosphorylation	1	511	5.16e-01
GO:BP	GO:0006974	DNA damage response	1	795	5.18e-01
GO:BP	GO:1903047	mitotic cell cycle process	1	689	5.30e-01
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	1	559	5.50e-01
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	1	559	5.50e-01
GO:BP	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1	288	5.55e-01
GO:BP	GO:0000398	mRNA splicing, via spliceosome	1	288	5.55e-01
GO:BP	GO:0000375	RNA splicing, via transesterification reactions	1	292	5.55e-01
GO:BP	GO:0032870	cellular response to hormone stimulus	1	449	5.55e-01
GO:BP	GO:0031323	regulation of cellular metabolic process	1	4563	5.55e-01
GO:BP	GO:0060255	regulation of macromolecule metabolic process	1	4593	5.58e-01
GO:BP	GO:0030003	intracellular monoatomic cation homeostasis	1	364	5.62e-01
GO:BP	GO:0030155	regulation of cell adhesion	1	535	5.64e-01
GO:BP	GO:0098771	inorganic ion homeostasis	1	355	5.66e-01
GO:BP	GO:0006873	intracellular monoatomic ion homeostasis	1	369	5.67e-01
GO:BP	GO:0016070	RNA metabolic process	1	3573	5.68e-01
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	1	680	5.73e-01
GO:BP	GO:0043066	negative regulation of apoptotic process	1	662	5.79e-01
GO:BP	GO:0008380	RNA splicing	1	426	5.79e-01
GO:BP	GO:0031401	positive regulation of protein modification process	1	664	5.81e-01
GO:BP	GO:0000278	mitotic cell cycle	1	815	5.86e-01
GO:BP	GO:0061061	muscle structure development	1	552	5.86e-01
GO:BP	GO:0043069	negative regulation of programmed cell death	1	685	5.86e-01
GO:BP	GO:0006397	mRNA processing	1	451	5.86e-01
GO:BP	GO:0051276	chromosome organization	1	533	5.87e-01
GO:BP	GO:0007600	sensory perception	1	259	6.00e-01
GO:BP	GO:0034660	ncRNA metabolic process	1	561	6.00e-01
GO:BP	GO:0051301	cell division	1	569	6.00e-01
GO:BP	GO:0007017	microtubule-based process	1	757	6.00e-01
GO:BP	GO:0051336	regulation of hydrolase activity	1	680	6.00e-01
GO:BP	GO:0090304	nucleic acid metabolic process	1	4018	6.00e-01
GO:BP	GO:0055080	monoatomic cation homeostasis	1	410	6.01e-01
GO:BP	GO:0050801	monoatomic ion homeostasis	1	416	6.06e-01
GO:BP	GO:0048609	multicellular organismal reproductive process	1	538	6.11e-01
GO:BP	GO:0007420	brain development	1	546	6.19e-01
GO:BP	GO:0098662	inorganic cation transmembrane transport	1	537	6.19e-01
GO:BP	GO:0098609	cell-cell adhesion	1	599	6.24e-01
GO:BP	GO:0016071	mRNA metabolic process	1	671	6.26e-01
GO:BP	GO:0098655	monoatomic cation transmembrane transport	1	554	6.28e-01
GO:BP	GO:0032504	multicellular organism reproduction	1	558	6.28e-01
GO:BP	GO:0044087	regulation of cellular component biogenesis	1	802	6.30e-01
GO:BP	GO:0007165	signal transduction	2	3803	6.30e-01
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	1	4423	6.31e-01
GO:BP	GO:0030001	metal ion transport	1	568	6.34e-01
GO:BP	GO:0009653	anatomical structure morphogenesis	3	1952	6.34e-01
GO:BP	GO:0060322	head development	1	588	6.35e-01
GO:BP	GO:0070887	cellular response to chemical stimulus	3	1857	6.35e-01
GO:BP	GO:0016043	cellular component organization	1	5106	6.35e-01
GO:BP	GO:0046483	heterocycle metabolic process	1	4537	6.40e-01
GO:BP	GO:0006725	cellular aromatic compound metabolic process	1	4561	6.43e-01
GO:BP	GO:0098660	inorganic ion transmembrane transport	1	582	6.48e-01
GO:BP	GO:0071840	cellular component organization or biogenesis	1	5307	6.49e-01
GO:BP	GO:0010033	response to organic substance	3	1942	6.54e-01
GO:BP	GO:0055082	intracellular chemical homeostasis	1	498	6.55e-01
GO:BP	GO:1901360	organic cyclic compound metabolic process	1	4713	6.57e-01
GO:BP	GO:0009725	response to hormone	1	624	6.59e-01
GO:BP	GO:0010564	regulation of cell cycle process	1	622	6.59e-01
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	1	868	6.62e-01
GO:BP	GO:0010628	positive regulation of gene expression	1	795	6.65e-01
GO:BP	GO:0034641	cellular nitrogen compound metabolic process	1	4913	6.66e-01
GO:BP	GO:0051128	regulation of cellular component organization	3	1981	6.77e-01
GO:BP	GO:0034220	monoatomic ion transmembrane transport	1	650	6.81e-01
GO:BP	GO:0006812	monoatomic cation transport	1	677	6.86e-01
GO:BP	GO:0019725	cellular homeostasis	1	583	7.01e-01
GO:BP	GO:0010467	gene expression	1	4733	7.05e-01
GO:BP	GO:0008284	positive regulation of cell population proliferation	1	886	7.14e-01
GO:BP	GO:0051247	positive regulation of protein metabolic process	1	1067	7.19e-01
GO:BP	GO:0007166	cell surface receptor signaling pathway	2	1889	7.19e-01
GO:BP	GO:0007417	central nervous system development	1	750	7.22e-01
GO:BP	GO:0009059	macromolecule biosynthetic process	1	5148	7.39e-01
GO:BP	GO:0007010	cytoskeleton organization	1	1186	7.39e-01
GO:BP	GO:0050877	nervous system process	1	628	7.47e-01
GO:BP	GO:0006811	monoatomic ion transport	1	788	7.50e-01
GO:BP	GO:0030030	cell projection organization	1	1236	7.67e-01
GO:BP	GO:0050794	regulation of cellular process	2	7632	7.71e-01
GO:BP	GO:0051716	cellular response to stimulus	2	4929	7.73e-01
GO:BP	GO:0007155	cell adhesion	1	996	7.76e-01
GO:BP	GO:0006396	RNA processing	1	928	7.79e-01
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	1	918	7.83e-01
GO:BP	GO:0033365	protein localization to organelle	1	860	7.85e-01
GO:BP	GO:0044249	cellular biosynthetic process	1	5813	7.93e-01
GO:BP	GO:1901576	organic substance biosynthetic process	1	5875	7.99e-01
GO:BP	GO:0009058	biosynthetic process	1	5912	8.02e-01
GO:BP	GO:0033043	regulation of organelle organization	1	1001	8.14e-01
GO:BP	GO:0050789	regulation of biological process	2	8017	8.37e-01
GO:BP	GO:0007186	G protein-coupled receptor signaling pathway	1	386	8.37e-01
GO:BP	GO:0042221	response to chemical	3	2456	8.73e-01
GO:BP	GO:0065007	biological regulation	2	8282	8.93e-01
GO:BP	GO:0006996	organelle organization	3	2974	8.99e-01
GO:BP	GO:0006807	nitrogen compound metabolic process	1	7431	9.01e-01
GO:BP	GO:0043170	macromolecule metabolic process	1	7084	9.16e-01
GO:BP	GO:0044238	primary metabolic process	1	7788	9.40e-01
GO:BP	GO:0044237	cellular metabolic process	1	7562	9.57e-01
GO:BP	GO:0022607	cellular component assembly	2	2459	9.95e-01
GO:BP	GO:0044085	cellular component biogenesis	2	2722	9.97e-01
GO:BP	GO:0009987	cellular process	1	11410	1.00e+00
GO:BP	GO:0008152	metabolic process	1	8522	1.00e+00
GO:BP	GO:0008150	biological_process	1	12027	1.00e+00
GO:BP	GO:0071704	organic substance metabolic process	1	8176	1.00e+00
KEGG	KEGG:05202	Transcriptional misregulation in cancer	3	128	3.30e-04
KEGG	KEGG:04115	p53 signaling pathway	2	65	5.02e-04
KEGG	KEGG:05223	Non-small cell lung cancer	3	67	5.02e-04
KEGG	KEGG:05212	Pancreatic cancer	2	75	5.02e-04
KEGG	KEGG:05222	Small cell lung cancer	3	87	5.02e-04
KEGG	KEGG:05213	Endometrial cancer	2	57	5.02e-04
KEGG	KEGG:05214	Glioma	2	67	5.02e-04
KEGG	KEGG:05216	Thyroid cancer	2	35	5.02e-04
KEGG	KEGG:05220	Chronic myeloid leukemia	2	75	5.02e-04
KEGG	KEGG:05217	Basal cell carcinoma	2	49	5.02e-04
KEGG	KEGG:05218	Melanoma	2	58	5.02e-04
KEGG	KEGG:05210	Colorectal cancer	2	84	5.89e-04
KEGG	KEGG:04064	NF-kappa B signaling pathway	2	71	7.65e-04
KEGG	KEGG:05226	Gastric cancer	3	117	1.09e-03
KEGG	KEGG:04210	Apoptosis	2	118	1.09e-03
KEGG	KEGG:04068	FoxO signaling pathway	2	109	1.09e-03
KEGG	KEGG:05224	Breast cancer	2	117	1.21e-03
KEGG	KEGG:04218	Cellular senescence	2	145	1.24e-03
KEGG	KEGG:04110	Cell cycle	2	151	1.24e-03
KEGG	KEGG:05225	Hepatocellular carcinoma	2	145	1.31e-03
KEGG	KEGG:05169	Epstein-Barr virus infection	2	153	1.78e-03
KEGG	KEGG:04710	Circadian rhythm	1	30	3.41e-03
KEGG	KEGG:04010	MAPK signaling pathway	2	240	3.55e-03
KEGG	KEGG:05221	Acute myeloid leukemia	1	56	6.16e-03
KEGG	KEGG:04713	Circadian entrainment	1	69	8.57e-03
KEGG	KEGG:05200	Pathways in cancer	2	409	9.94e-03
KEGG	KEGG:04114	Oocyte meiosis	1	108	1.57e-01
KEGG	KEGG:05206	MicroRNAs in cancer	1	149	2.40e-01
KEGG	KEGG:05168	Herpes simplex virus 1 infection	1	415	2.41e-01
KEGG	KEGG:00000	KEGG root term	2	5548	3.61e-01

TRZnomtable3h %>%
  filter(source=="KEGG") %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "Enrichment of KEGG terms using nominal pvalue TRZ 3hour genes in my data") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

Enrichment of KEGG terms using nominal pvalue TRZ 3hour genes in my data

source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:05202	Transcriptional misregulation in cancer	3	128	3.30e-04
KEGG	KEGG:04115	p53 signaling pathway	2	65	5.02e-04
KEGG	KEGG:05223	Non-small cell lung cancer	3	67	5.02e-04
KEGG	KEGG:05212	Pancreatic cancer	2	75	5.02e-04
KEGG	KEGG:05222	Small cell lung cancer	3	87	5.02e-04
KEGG	KEGG:05213	Endometrial cancer	2	57	5.02e-04
KEGG	KEGG:05214	Glioma	2	67	5.02e-04
KEGG	KEGG:05216	Thyroid cancer	2	35	5.02e-04
KEGG	KEGG:05220	Chronic myeloid leukemia	2	75	5.02e-04
KEGG	KEGG:05217	Basal cell carcinoma	2	49	5.02e-04
KEGG	KEGG:05218	Melanoma	2	58	5.02e-04
KEGG	KEGG:05210	Colorectal cancer	2	84	5.89e-04
KEGG	KEGG:04064	NF-kappa B signaling pathway	2	71	7.65e-04
KEGG	KEGG:05226	Gastric cancer	3	117	1.09e-03
KEGG	KEGG:04210	Apoptosis	2	118	1.09e-03
KEGG	KEGG:04068	FoxO signaling pathway	2	109	1.09e-03
KEGG	KEGG:05224	Breast cancer	2	117	1.21e-03
KEGG	KEGG:04218	Cellular senescence	2	145	1.24e-03
KEGG	KEGG:04110	Cell cycle	2	151	1.24e-03
KEGG	KEGG:05225	Hepatocellular carcinoma	2	145	1.31e-03
KEGG	KEGG:05169	Epstein-Barr virus infection	2	153	1.78e-03
KEGG	KEGG:04710	Circadian rhythm	1	30	3.41e-03
KEGG	KEGG:04010	MAPK signaling pathway	2	240	3.55e-03
KEGG	KEGG:05221	Acute myeloid leukemia	1	56	6.16e-03
KEGG	KEGG:04713	Circadian entrainment	1	69	8.57e-03
KEGG	KEGG:05200	Pathways in cancer	2	409	9.94e-03
KEGG	KEGG:04114	Oocyte meiosis	1	108	1.57e-01
KEGG	KEGG:05206	MicroRNAs in cancer	1	149	2.40e-01
KEGG	KEGG:05168	Herpes simplex virus 1 infection	1	415	2.41e-01
KEGG	KEGG:00000	KEGG root term	2	5548	3.61e-01

TRZ 24 hour nom de

# TRZresgenes24h <- gost(query = TRZ_list24h$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = TRUE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = backGL$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(TRZresgenes24h,"data/DEG-GO/TRZresgenes24h.RDS")
TRZresgenes24h <- readRDS("data/DEG-GO/TRZresgenes24h.RDS")

TRZnom24h <- gostplot(TRZresgenes24h, capped = FALSE, interactive = TRUE)
TRZnom24h

TRZnomtable24h <- TRZresgenes24h$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

TRZnomtable24h %>%
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0098728	germline stem cell asymmetric division	1	2	6.00e-02
GO:BP	GO:0048133	male germ-line stem cell asymmetric division	1	2	6.00e-02
GO:BP	GO:0042078	germ-line stem cell division	1	2	6.00e-02
GO:BP	GO:0098722	asymmetric stem cell division	1	2	6.00e-02
GO:BP	GO:0015757	galactose transmembrane transport	1	4	9.34e-02
GO:BP	GO:0098708	glucose import across plasma membrane	1	5	9.34e-02
GO:BP	GO:0098704	carbohydrate import across plasma membrane	1	5	9.34e-02
GO:BP	GO:0062197	cellular response to chemical stress	3	269	9.34e-02
GO:BP	GO:0061643	chemorepulsion of axon	1	6	9.34e-02
GO:BP	GO:0060252	positive regulation of glial cell proliferation	1	14	9.34e-02
GO:BP	GO:0060251	regulation of glial cell proliferation	1	26	9.34e-02
GO:BP	GO:0051939	gamma-aminobutyric acid import	1	3	9.34e-02
GO:BP	GO:0051764	actin crosslink formation	1	9	9.34e-02
GO:BP	GO:0006979	response to oxidative stress	3	328	9.34e-02
GO:BP	GO:0048232	male gamete generation	2	346	9.34e-02
GO:BP	GO:0014009	glial cell proliferation	1	40	9.34e-02
GO:BP	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	1	7	9.34e-02
GO:BP	GO:0042918	alkanesulfonate transport	1	6	9.34e-02
GO:BP	GO:0008356	asymmetric cell division	1	14	9.34e-02
GO:BP	GO:0014015	positive regulation of gliogenesis	1	44	9.34e-02
GO:BP	GO:0007283	spermatogenesis	2	333	9.34e-02
GO:BP	GO:0007288	sperm axoneme assembly	1	20	9.34e-02
GO:BP	GO:0036159	inner dynein arm assembly	1	8	9.34e-02
GO:BP	GO:0034599	cellular response to oxidative stress	3	218	9.34e-02
GO:BP	GO:0022412	cellular process involved in reproduction in multicellular organism	2	255	9.34e-02
GO:BP	GO:0018345	protein palmitoylation	1	30	9.34e-02
GO:BP	GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	1	21	9.34e-02
GO:BP	GO:0018230	peptidyl-L-cysteine S-palmitoylation	1	21	9.34e-02
GO:BP	GO:0017145	stem cell division	1	25	9.34e-02
GO:BP	GO:0015734	taurine transport	1	6	9.34e-02
GO:BP	GO:0007281	germ cell development	2	194	9.34e-02
GO:BP	GO:0010232	vascular transport	2	72	9.34e-02
GO:BP	GO:1902965	regulation of protein localization to early endosome	1	10	9.34e-02
GO:BP	GO:1902966	positive regulation of protein localization to early endosome	1	10	9.34e-02
GO:BP	GO:1904059	regulation of locomotor rhythm	1	3	9.34e-02
GO:BP	GO:1904350	regulation of protein catabolic process in the vacuole	1	13	9.34e-02
GO:BP	GO:1904351	negative regulation of protein catabolic process in the vacuole	1	5	9.34e-02
GO:BP	GO:1905165	regulation of lysosomal protein catabolic process	1	11	9.34e-02
GO:BP	GO:1905166	negative regulation of lysosomal protein catabolic process	1	5	9.34e-02
GO:BP	GO:1905668	positive regulation of protein localization to endosome	1	14	9.34e-02
GO:BP	GO:0150104	transport across blood-brain barrier	2	72	9.34e-02
GO:BP	GO:1902946	protein localization to early endosome	1	12	9.34e-02
GO:BP	GO:1990708	conditioned place preference	1	2	9.34e-02
GO:BP	GO:0140271	hexose import across plasma membrane	1	5	9.34e-02
GO:BP	GO:1905666	regulation of protein localization to endosome	1	15	9.57e-02
GO:BP	GO:0018198	peptidyl-cysteine modification	1	41	9.78e-02
GO:BP	GO:0045666	positive regulation of neuron differentiation	1	63	9.78e-02
GO:BP	GO:0014013	regulation of gliogenesis	1	66	1.02e-01
GO:BP	GO:0006044	N-acetylglucosamine metabolic process	1	16	1.05e-01
GO:BP	GO:0070286	axonemal dynein complex assembly	1	21	1.10e-01
GO:BP	GO:0015812	gamma-aminobutyric acid transport	1	11	1.10e-01
GO:BP	GO:0120316	sperm flagellum assembly	1	27	1.10e-01
GO:BP	GO:1905146	lysosomal protein catabolic process	1	19	1.10e-01
GO:BP	GO:0070837	dehydroascorbic acid transport	1	7	1.10e-01
GO:BP	GO:0032328	alanine transport	1	13	1.10e-01
GO:BP	GO:0003351	epithelial cilium movement involved in extracellular fluid movement	1	30	1.10e-01
GO:BP	GO:1901334	lactone metabolic process	1	10	1.11e-01
GO:BP	GO:0006858	extracellular transport	1	33	1.11e-01
GO:BP	GO:0010887	negative regulation of cholesterol storage	1	8	1.11e-01
GO:BP	GO:0007039	protein catabolic process in the vacuole	1	22	1.11e-01
GO:BP	GO:0007276	gamete generation	2	465	1.11e-01
GO:BP	GO:0019852	L-ascorbic acid metabolic process	1	10	1.11e-01
GO:BP	GO:1901071	glucosamine-containing compound metabolic process	1	19	1.14e-01
GO:BP	GO:0036010	protein localization to endosome	1	28	1.25e-01
GO:BP	GO:0048609	multicellular organismal reproductive process	2	538	1.27e-01
GO:BP	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	1	8	1.30e-01
GO:BP	GO:0044458	motile cilium assembly	1	46	1.34e-01
GO:BP	GO:0042158	lipoprotein biosynthetic process	1	92	1.34e-01
GO:BP	GO:0045664	regulation of neuron differentiation	1	137	1.34e-01
GO:BP	GO:0098739	import across plasma membrane	2	130	1.34e-01
GO:BP	GO:0038003	G protein-coupled opioid receptor signaling pathway	1	5	1.34e-01
GO:BP	GO:0006497	protein lipidation	1	89	1.34e-01
GO:BP	GO:0032504	multicellular organism reproduction	2	558	1.34e-01
GO:BP	GO:0003006	developmental process involved in reproduction	2	603	1.34e-01
GO:BP	GO:0019953	sexual reproduction	2	633	1.43e-01
GO:BP	GO:0035810	positive regulation of urine volume	1	10	1.43e-01
GO:BP	GO:0106070	regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	1	11	1.43e-01
GO:BP	GO:0051382	kinetochore assembly	1	17	1.43e-01
GO:BP	GO:0043951	negative regulation of cAMP-mediated signaling	1	10	1.43e-01
GO:BP	GO:0050769	positive regulation of neurogenesis	1	190	1.43e-01
GO:BP	GO:0006040	amino sugar metabolic process	1	34	1.46e-01
GO:BP	GO:0016202	regulation of striated muscle tissue development	1	13	1.46e-01
GO:BP	GO:0010885	regulation of cholesterol storage	1	13	1.47e-01
GO:BP	GO:0044849	estrous cycle	1	14	1.51e-01
GO:BP	GO:0045475	locomotor rhythm	1	13	1.51e-01
GO:BP	GO:0042157	lipoprotein metabolic process	1	116	1.54e-01
GO:BP	GO:0045662	negative regulation of myoblast differentiation	1	20	1.54e-01
GO:BP	GO:0051962	positive regulation of nervous system development	1	222	1.54e-01
GO:BP	GO:0035082	axoneme assembly	1	54	1.54e-01
GO:BP	GO:0051383	kinetochore organization	1	21	1.54e-01
GO:BP	GO:0000226	microtubule cytoskeleton organization	2	549	1.54e-01
GO:BP	GO:0050435	amyloid-beta metabolic process	1	48	1.61e-01
GO:BP	GO:0010888	negative regulation of lipid storage	1	15	1.63e-01
GO:BP	GO:0048634	regulation of muscle organ development	1	14	1.63e-01
GO:BP	GO:0089718	amino acid import across plasma membrane	1	38	1.67e-01
GO:BP	GO:0010878	cholesterol storage	1	18	1.67e-01
GO:BP	GO:0048843	negative regulation of axon extension involved in axon guidance	1	26	1.67e-01
GO:BP	GO:0042063	gliogenesis	1	244	1.67e-01
GO:BP	GO:0003018	vascular process in circulatory system	2	198	1.67e-01
GO:BP	GO:1901386	negative regulation of voltage-gated calcium channel activity	1	14	1.67e-01
GO:BP	GO:0072348	sulfur compound transport	1	36	1.71e-01
GO:BP	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	1	33	1.74e-01
GO:BP	GO:0035809	regulation of urine volume	1	14	1.74e-01
GO:BP	GO:0001578	microtubule bundle formation	1	79	1.74e-01
GO:BP	GO:0050767	regulation of neurogenesis	1	302	1.75e-01
GO:BP	GO:0030317	flagellated sperm motility	1	62	1.78e-01
GO:BP	GO:0043543	protein acylation	1	193	1.78e-01
GO:BP	GO:0034508	centromere complex assembly	1	29	1.78e-01
GO:BP	GO:0015804	neutral amino acid transport	1	43	1.78e-01
GO:BP	GO:0097722	sperm motility	1	62	1.78e-01
GO:BP	GO:0048841	regulation of axon extension involved in axon guidance	1	31	1.78e-01
GO:BP	GO:0006487	protein N-linked glycosylation	1	65	1.81e-01
GO:BP	GO:0043620	regulation of DNA-templated transcription in response to stress	1	38	1.81e-01
GO:BP	GO:1902284	neuron projection extension involved in neuron projection guidance	1	35	1.81e-01
GO:BP	GO:0048846	axon extension involved in axon guidance	1	35	1.81e-01
GO:BP	GO:0015800	acidic amino acid transport	1	39	1.81e-01
GO:BP	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	1	30	1.81e-01
GO:BP	GO:0060294	cilium movement involved in cell motility	1	69	1.81e-01
GO:BP	GO:0010720	positive regulation of cell development	1	318	1.81e-01
GO:BP	GO:0021591	ventricular system development	1	29	1.82e-01
GO:BP	GO:0051960	regulation of nervous system development	1	357	1.82e-01
GO:BP	GO:0022414	reproductive process	2	924	1.82e-01
GO:BP	GO:0060285	cilium-dependent cell motility	1	72	1.82e-01
GO:BP	GO:0001539	cilium or flagellum-dependent cell motility	1	72	1.82e-01
GO:BP	GO:0000003	reproduction	2	933	1.83e-01
GO:BP	GO:0071526	semaphorin-plexin signaling pathway	1	44	2.02e-01
GO:BP	GO:0090181	regulation of cholesterol metabolic process	1	27	2.02e-01
GO:BP	GO:0003013	circulatory system process	3	445	2.03e-01
GO:BP	GO:0030517	negative regulation of axon extension	1	41	2.03e-01
GO:BP	GO:0045595	regulation of cell differentiation	4	1122	2.03e-01
GO:BP	GO:0050919	negative chemotaxis	1	42	2.03e-01
GO:BP	GO:0007017	microtubule-based process	2	757	2.05e-01
GO:BP	GO:0043949	regulation of cAMP-mediated signaling	1	17	2.05e-01
GO:BP	GO:0033048	negative regulation of mitotic sister chromatid segregation	1	45	2.06e-01
GO:BP	GO:1901861	regulation of muscle tissue development	1	34	2.06e-01
GO:BP	GO:0003341	cilium movement	1	97	2.06e-01
GO:BP	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	1	28	2.06e-01
GO:BP	GO:0099111	microtubule-based transport	1	192	2.06e-01
GO:BP	GO:0051301	cell division	1	569	2.06e-01
GO:BP	GO:1902100	negative regulation of metaphase/anaphase transition of cell cycle	1	46	2.06e-01
GO:BP	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	1	45	2.06e-01
GO:BP	GO:0007094	mitotic spindle assembly checkpoint signaling	1	43	2.06e-01
GO:BP	GO:0071174	mitotic spindle checkpoint signaling	1	43	2.06e-01
GO:BP	GO:0010874	regulation of cholesterol efflux	1	31	2.06e-01
GO:BP	GO:0051180	vitamin transport	1	29	2.06e-01
GO:BP	GO:0042755	eating behavior	1	16	2.06e-01
GO:BP	GO:0051985	negative regulation of chromosome segregation	1	46	2.06e-01
GO:BP	GO:0033046	negative regulation of sister chromatid segregation	1	45	2.06e-01
GO:BP	GO:2000816	negative regulation of mitotic sister chromatid separation	1	45	2.06e-01
GO:BP	GO:0071173	spindle assembly checkpoint signaling	1	43	2.06e-01
GO:BP	GO:0009988	cell-cell recognition	1	31	2.06e-01
GO:BP	GO:0007286	spermatid development	1	108	2.06e-01
GO:BP	GO:1905819	negative regulation of chromosome separation	1	46	2.06e-01
GO:BP	GO:0042177	negative regulation of protein catabolic process	1	100	2.06e-01
GO:BP	GO:0031577	spindle checkpoint signaling	1	44	2.06e-01
GO:BP	GO:0048515	spermatid differentiation	1	114	2.06e-01
GO:BP	GO:0007517	muscle organ development	2	279	2.08e-01
GO:BP	GO:0003333	amino acid transmembrane transport	1	70	2.08e-01
GO:BP	GO:0006612	protein targeting to membrane	1	120	2.08e-01
GO:BP	GO:0001755	neural crest cell migration	1	49	2.08e-01
GO:BP	GO:1905953	negative regulation of lipid localization	1	31	2.09e-01
GO:BP	GO:0090497	mesenchymal cell migration	1	51	2.12e-01
GO:BP	GO:0050922	negative regulation of chemotaxis	1	44	2.12e-01
GO:BP	GO:0033047	regulation of mitotic sister chromatid segregation	1	51	2.12e-01
GO:BP	GO:0048512	circadian behavior	1	30	2.14e-01
GO:BP	GO:1901385	regulation of voltage-gated calcium channel activity	1	29	2.15e-01
GO:BP	GO:0006767	water-soluble vitamin metabolic process	1	50	2.15e-01
GO:BP	GO:0045839	negative regulation of mitotic nuclear division	1	53	2.15e-01
GO:BP	GO:0010883	regulation of lipid storage	1	38	2.17e-01
GO:BP	GO:0007622	rhythmic behavior	1	32	2.18e-01
GO:BP	GO:0050771	negative regulation of axonogenesis	1	59	2.20e-01
GO:BP	GO:0010965	regulation of mitotic sister chromatid separation	1	56	2.20e-01
GO:BP	GO:0045661	regulation of myoblast differentiation	1	60	2.20e-01
GO:BP	GO:2001258	negative regulation of cation channel activity	1	31	2.22e-01
GO:BP	GO:0060284	regulation of cell development	1	593	2.27e-01
GO:BP	GO:0045776	negative regulation of blood pressure	1	30	2.27e-01
GO:BP	GO:0051784	negative regulation of nuclear division	1	56	2.27e-01
GO:BP	GO:0051306	mitotic sister chromatid separation	1	59	2.27e-01
GO:BP	GO:0015711	organic anion transport	2	270	2.28e-01
GO:BP	GO:1903170	negative regulation of calcium ion transmembrane transport	1	35	2.28e-01
GO:BP	GO:0045597	positive regulation of cell differentiation	1	618	2.28e-01
GO:BP	GO:0033344	cholesterol efflux	1	41	2.29e-01
GO:BP	GO:0050890	cognition	2	226	2.31e-01
GO:BP	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	1	36	2.32e-01
GO:BP	GO:0046323	glucose import	1	55	2.38e-01
GO:BP	GO:0014032	neural crest cell development	1	70	2.45e-01
GO:BP	GO:0032371	regulation of sterol transport	1	45	2.45e-01
GO:BP	GO:0032374	regulation of cholesterol transport	1	45	2.45e-01
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	1	744	2.46e-01
GO:BP	GO:1905818	regulation of chromosome separation	1	69	2.46e-01
GO:BP	GO:0019933	cAMP-mediated signaling	1	35	2.46e-01
GO:BP	GO:0090150	establishment of protein localization to membrane	1	258	2.46e-01
GO:BP	GO:0006865	amino acid transport	1	103	2.46e-01
GO:BP	GO:0048864	stem cell development	1	75	2.52e-01
GO:BP	GO:1905039	carboxylic acid transmembrane transport	1	111	2.53e-01
GO:BP	GO:1903825	organic acid transmembrane transport	1	112	2.54e-01
GO:BP	GO:0060271	cilium assembly	1	296	2.62e-01
GO:BP	GO:0006605	protein targeting	1	310	2.62e-01
GO:BP	GO:0014033	neural crest cell differentiation	1	79	2.62e-01
GO:BP	GO:0030516	regulation of axon extension	1	82	2.62e-01
GO:BP	GO:0051304	chromosome separation	1	75	2.62e-01
GO:BP	GO:0051926	negative regulation of calcium ion transport	1	45	2.67e-01
GO:BP	GO:0098916	anterograde trans-synaptic signaling	2	490	2.69e-01
GO:BP	GO:0007268	chemical synaptic transmission	2	490	2.69e-01
GO:BP	GO:0099537	trans-synaptic signaling	2	494	2.71e-01
GO:BP	GO:0045445	myoblast differentiation	1	90	2.73e-01
GO:BP	GO:0044782	cilium organization	1	317	2.73e-01
GO:BP	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	1	37	2.74e-01
GO:BP	GO:0042632	cholesterol homeostasis	1	58	2.74e-01
GO:BP	GO:0030071	regulation of mitotic metaphase/anaphase transition	1	87	2.74e-01
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	1	918	2.74e-01
GO:BP	GO:0043413	macromolecule glycosylation	1	185	2.74e-01
GO:BP	GO:0035725	sodium ion transmembrane transport	1	112	2.74e-01
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	1	1005	2.74e-01
GO:BP	GO:0007018	microtubule-based movement	1	300	2.74e-01
GO:BP	GO:0048640	negative regulation of developmental growth	1	94	2.74e-01
GO:BP	GO:0044784	metaphase/anaphase transition of cell cycle	1	92	2.74e-01
GO:BP	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	1	91	2.74e-01
GO:BP	GO:0007010	cytoskeleton organization	2	1186	2.74e-01
GO:BP	GO:0032413	negative regulation of ion transmembrane transporter activity	1	52	2.74e-01
GO:BP	GO:0042698	ovulation cycle	1	54	2.74e-01
GO:BP	GO:0061387	regulation of extent of cell growth	1	96	2.74e-01
GO:BP	GO:0008037	cell recognition	1	82	2.74e-01
GO:BP	GO:0055092	sterol homeostasis	1	59	2.74e-01
GO:BP	GO:0006766	vitamin metabolic process	1	75	2.74e-01
GO:BP	GO:0008284	positive regulation of cell population proliferation	1	886	2.74e-01
GO:BP	GO:0006486	protein glycosylation	1	185	2.74e-01
GO:BP	GO:0099536	synaptic signaling	2	512	2.74e-01
GO:BP	GO:0051310	metaphase chromosome alignment	1	87	2.74e-01
GO:BP	GO:0051094	positive regulation of developmental process	1	957	2.74e-01
GO:BP	GO:1902099	regulation of metaphase/anaphase transition of cell cycle	1	88	2.74e-01
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	1	1014	2.74e-01
GO:BP	GO:0010389	regulation of G2/M transition of mitotic cell cycle	1	94	2.74e-01
GO:BP	GO:0050795	regulation of behavior	1	41	2.74e-01
GO:BP	GO:0050793	regulation of developmental process	5	1813	2.74e-01
GO:BP	GO:2001251	negative regulation of chromosome organization	1	89	2.74e-01
GO:BP	GO:0019915	lipid storage	1	68	2.74e-01
GO:BP	GO:0006836	neurotransmitter transport	1	141	2.74e-01
GO:BP	GO:0032410	negative regulation of transporter activity	1	59	2.75e-01
GO:BP	GO:0008645	hexose transmembrane transport	1	87	2.75e-01
GO:BP	GO:1904659	glucose transmembrane transport	1	84	2.75e-01
GO:BP	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	1	102	2.75e-01
GO:BP	GO:2000026	regulation of multicellular organismal development	1	997	2.75e-01
GO:BP	GO:0033045	regulation of sister chromatid segregation	1	99	2.75e-01
GO:BP	GO:0070085	glycosylation	1	197	2.75e-01
GO:BP	GO:0019218	regulation of steroid metabolic process	1	68	2.75e-01
GO:BP	GO:0051303	establishment of chromosome localization	1	93	2.75e-01
GO:BP	GO:0048675	axon extension	1	108	2.75e-01
GO:BP	GO:0019233	sensory perception of pain	1	39	2.75e-01
GO:BP	GO:0051253	negative regulation of RNA metabolic process	1	1112	2.75e-01
GO:BP	GO:0030182	neuron differentiation	1	1058	2.75e-01
GO:BP	GO:0048468	cell development	2	1950	2.76e-01
GO:BP	GO:0019935	cyclic-nucleotide-mediated signaling	1	52	2.76e-01
GO:BP	GO:0015749	monosaccharide transmembrane transport	1	88	2.76e-01
GO:BP	GO:0008306	associative learning	1	65	2.76e-01
GO:BP	GO:0048699	generation of neurons	1	1120	2.78e-01
GO:BP	GO:1902749	regulation of cell cycle G2/M phase transition	1	105	2.80e-01
GO:BP	GO:1904063	negative regulation of cation transmembrane transport	1	64	2.81e-01
GO:BP	GO:0050000	chromosome localization	1	101	2.81e-01
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	1	1203	2.86e-01
GO:BP	GO:0007088	regulation of mitotic nuclear division	1	99	2.86e-01
GO:BP	GO:0010977	negative regulation of neuron projection development	1	117	2.89e-01
GO:BP	GO:0034219	carbohydrate transmembrane transport	1	95	2.89e-01
GO:BP	GO:0045596	negative regulation of cell differentiation	2	471	2.89e-01
GO:BP	GO:0072657	protein localization to membrane	1	530	2.89e-01
GO:BP	GO:1901019	regulation of calcium ion transmembrane transporter activity	1	70	2.91e-01
GO:BP	GO:0006814	sodium ion transport	1	158	2.92e-01
GO:BP	GO:0051240	positive regulation of multicellular organismal process	1	1103	2.92e-01
GO:BP	GO:0034766	negative regulation of monoatomic ion transmembrane transport	1	70	2.92e-01
GO:BP	GO:0030301	cholesterol transport	1	81	2.92e-01
GO:BP	GO:0120031	plasma membrane bounded cell projection assembly	1	463	2.93e-01
GO:BP	GO:0050768	negative regulation of neurogenesis	1	113	2.93e-01
GO:BP	GO:0007416	synapse assembly	1	153	2.95e-01
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	1	1305	2.95e-01
GO:BP	GO:0030031	cell projection assembly	1	473	2.95e-01
GO:BP	GO:0051983	regulation of chromosome segregation	1	121	2.95e-01
GO:BP	GO:0022008	neurogenesis	1	1297	2.95e-01
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	1	1298	2.95e-01
GO:BP	GO:0051961	negative regulation of nervous system development	1	119	2.99e-01
GO:BP	GO:0051668	localization within membrane	1	611	3.03e-01
GO:BP	GO:0050770	regulation of axonogenesis	1	139	3.03e-01
GO:BP	GO:0009101	glycoprotein biosynthetic process	1	251	3.03e-01
GO:BP	GO:0007631	feeding behavior	1	51	3.03e-01
GO:BP	GO:0000086	G2/M transition of mitotic cell cycle	1	130	3.06e-01
GO:BP	GO:0015918	sterol transport	1	93	3.09e-01
GO:BP	GO:0007218	neuropeptide signaling pathway	1	36	3.09e-01
GO:BP	GO:0051254	positive regulation of RNA metabolic process	1	1425	3.09e-01
GO:BP	GO:0007093	mitotic cell cycle checkpoint signaling	1	137	3.10e-01
GO:BP	GO:0008643	carbohydrate transport	1	114	3.11e-01
GO:BP	GO:0042752	regulation of circadian rhythm	1	93	3.13e-01
GO:BP	GO:0051783	regulation of nuclear division	1	115	3.13e-01
GO:BP	GO:0032355	response to estradiol	1	79	3.14e-01
GO:BP	GO:0033554	cellular response to stress	1	1662	3.14e-01
GO:BP	GO:0008283	cell population proliferation	2	2340	3.14e-01
GO:BP	GO:0009895	negative regulation of catabolic process	1	287	3.14e-01
GO:BP	GO:0032368	regulation of lipid transport	1	91	3.23e-01
GO:BP	GO:0044839	cell cycle G2/M phase transition	1	145	3.23e-01
GO:BP	GO:0008203	cholesterol metabolic process	1	99	3.23e-01
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	1	1589	3.24e-01
GO:BP	GO:1990138	neuron projection extension	1	149	3.24e-01
GO:BP	GO:0042176	regulation of protein catabolic process	1	328	3.24e-01
GO:BP	GO:0061061	muscle structure development	2	552	3.24e-01
GO:BP	GO:0003014	renal system process	1	76	3.25e-01
GO:BP	GO:0007267	cell-cell signaling	4	1150	3.26e-01
GO:BP	GO:0018193	peptidyl-amino acid modification	1	866	3.26e-01
GO:BP	GO:0034763	negative regulation of transmembrane transport	1	96	3.26e-01
GO:BP	GO:0007015	actin filament organization	1	372	3.26e-01
GO:BP	GO:0008361	regulation of cell size	1	160	3.26e-01
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	1	114	3.26e-01
GO:BP	GO:0031345	negative regulation of cell projection organization	1	154	3.26e-01
GO:BP	GO:0043271	negative regulation of monoatomic ion transport	1	88	3.26e-01
GO:BP	GO:0006886	intracellular protein transport	1	803	3.26e-01
GO:BP	GO:1902652	secondary alcohol metabolic process	1	106	3.28e-01
GO:BP	GO:0003008	system process	4	1194	3.28e-01
GO:BP	GO:0030308	negative regulation of cell growth	1	161	3.28e-01
GO:BP	GO:0042127	regulation of cell population proliferation	1	1568	3.31e-01
GO:BP	GO:0009100	glycoprotein metabolic process	1	315	3.31e-01
GO:BP	GO:0048870	cell motility	2	1169	3.33e-01
GO:BP	GO:0016125	sterol metabolic process	1	108	3.33e-01
GO:BP	GO:0051129	negative regulation of cellular component organization	2	592	3.34e-01
GO:BP	GO:0008277	regulation of G protein-coupled receptor signaling pathway	1	93	3.34e-01
GO:BP	GO:0046942	carboxylic acid transport	1	213	3.34e-01
GO:BP	GO:0015849	organic acid transport	1	214	3.34e-01
GO:BP	GO:1901991	negative regulation of mitotic cell cycle phase transition	1	165	3.41e-01
GO:BP	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	1	165	3.43e-01
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	1	1832	3.43e-01
GO:BP	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	1	71	3.43e-01
GO:BP	GO:2001257	regulation of cation channel activity	1	100	3.43e-01
GO:BP	GO:1905952	regulation of lipid localization	1	110	3.43e-01
GO:BP	GO:0055088	lipid homeostasis	1	116	3.43e-01
GO:BP	GO:0000070	mitotic sister chromatid segregation	1	178	3.48e-01
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	1	1764	3.48e-01
GO:BP	GO:0050920	regulation of chemotaxis	1	143	3.55e-01
GO:BP	GO:0000075	cell cycle checkpoint signaling	1	184	3.55e-01
GO:BP	GO:0071897	DNA biosynthetic process	1	174	3.57e-01
GO:BP	GO:0007612	learning	1	114	3.57e-01
GO:BP	GO:0006366	transcription by RNA polymerase II	1	1852	3.57e-01
GO:BP	GO:0007399	nervous system development	1	1886	3.57e-01
GO:BP	GO:1901566	organonitrogen compound biosynthetic process	2	1496	3.57e-01
GO:BP	GO:0048588	developmental cell growth	1	194	3.58e-01
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	1	1896	3.65e-01
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	1	140	3.65e-01
GO:BP	GO:0097485	neuron projection guidance	1	177	3.65e-01
GO:BP	GO:0007411	axon guidance	1	177	3.65e-01
GO:BP	GO:0070887	cellular response to chemical stimulus	1	1857	3.65e-01
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	1	1958	3.65e-01
GO:BP	GO:0071702	organic substance transport	6	2133	3.65e-01
GO:BP	GO:0051093	negative regulation of developmental process	2	654	3.65e-01
GO:BP	GO:0045926	negative regulation of growth	1	204	3.65e-01
GO:BP	GO:0060560	developmental growth involved in morphogenesis	1	207	3.65e-01
GO:BP	GO:1903829	positive regulation of protein localization	1	392	3.65e-01
GO:BP	GO:0048762	mesenchymal cell differentiation	1	205	3.65e-01
GO:BP	GO:0030334	regulation of cell migration	2	707	3.65e-01
GO:BP	GO:0048863	stem cell differentiation	1	196	3.65e-01
GO:BP	GO:0009891	positive regulation of biosynthetic process	1	1972	3.65e-01
GO:BP	GO:0070925	organelle assembly	1	828	3.66e-01
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	1	1669	3.68e-01
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	1	1708	3.75e-01
GO:BP	GO:0009890	negative regulation of biosynthetic process	1	1721	3.75e-01
GO:BP	GO:0045930	negative regulation of mitotic cell cycle	1	209	3.82e-01
GO:BP	GO:0000819	sister chromatid segregation	1	217	3.83e-01
GO:BP	GO:1903169	regulation of calcium ion transmembrane transport	1	120	3.87e-01
GO:BP	GO:2000145	regulation of cell motility	2	741	3.87e-01
GO:BP	GO:0051239	regulation of multicellular organismal process	1	2052	3.90e-01
GO:BP	GO:0065004	protein-DNA complex assembly	1	171	3.90e-01
GO:BP	GO:0008217	regulation of blood pressure	1	114	3.90e-01
GO:BP	GO:0010721	negative regulation of cell development	1	190	3.90e-01
GO:BP	GO:0005996	monosaccharide metabolic process	1	212	3.94e-01
GO:BP	GO:0014706	striated muscle tissue development	1	214	3.96e-01
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	1	2367	3.96e-01
GO:BP	GO:0030036	actin cytoskeleton organization	1	566	3.96e-01
GO:BP	GO:0098657	import into cell	2	664	3.96e-01
GO:BP	GO:0050804	modulation of chemical synaptic transmission	1	343	3.98e-01
GO:BP	GO:0099177	regulation of trans-synaptic signaling	1	344	3.98e-01
GO:BP	GO:0040012	regulation of locomotion	2	762	3.98e-01
GO:BP	GO:0033044	regulation of chromosome organization	1	235	3.99e-01
GO:BP	GO:1901988	negative regulation of cell cycle phase transition	1	234	4.06e-01
GO:BP	GO:0030154	cell differentiation	2	2942	4.08e-01
GO:BP	GO:0048869	cellular developmental process	2	2943	4.08e-01
GO:BP	GO:0007623	circadian rhythm	1	160	4.08e-01
GO:BP	GO:0031324	negative regulation of cellular metabolic process	1	2069	4.08e-01
GO:BP	GO:0006936	muscle contraction	1	266	4.14e-01
GO:BP	GO:0060485	mesenchyme development	1	250	4.14e-01
GO:BP	GO:0007626	locomotory behavior	1	139	4.16e-01
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	1	2131	4.16e-01
GO:BP	GO:0048638	regulation of developmental growth	1	254	4.18e-01
GO:BP	GO:0015031	protein transport	1	1366	4.19e-01
GO:BP	GO:0046907	intracellular transport	1	1440	4.19e-01
GO:BP	GO:0030029	actin filament-based process	1	643	4.20e-01
GO:BP	GO:0140014	mitotic nuclear division	1	251	4.20e-01
GO:BP	GO:0031325	positive regulation of cellular metabolic process	1	2518	4.20e-01
GO:BP	GO:0006355	regulation of DNA-templated transcription	1	2560	4.21e-01
GO:BP	GO:2001141	regulation of RNA biosynthetic process	1	2577	4.22e-01
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	1	2607	4.24e-01
GO:BP	GO:0043547	positive regulation of GTPase activity	1	211	4.26e-01
GO:BP	GO:0040013	negative regulation of locomotion	1	262	4.26e-01
GO:BP	GO:1901137	carbohydrate derivative biosynthetic process	1	544	4.26e-01
GO:BP	GO:0097435	supramolecular fiber organization	1	666	4.26e-01
GO:BP	GO:0006351	DNA-templated transcription	1	2669	4.26e-01
GO:BP	GO:0034329	cell junction assembly	1	347	4.26e-01
GO:BP	GO:0009892	negative regulation of metabolic process	1	2297	4.26e-01
GO:BP	GO:0045184	establishment of protein localization	1	1468	4.27e-01
GO:BP	GO:0032774	RNA biosynthetic process	1	2699	4.29e-01
GO:BP	GO:0010948	negative regulation of cell cycle process	1	271	4.32e-01
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	1	214	4.35e-01
GO:BP	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	1	113	4.35e-01
GO:BP	GO:0051252	regulation of RNA metabolic process	1	2824	4.42e-01
GO:BP	GO:0050808	synapse organization	1	373	4.43e-01
GO:BP	GO:0098813	nuclear chromosome segregation	1	264	4.43e-01
GO:BP	GO:0006810	transport	2	3294	4.43e-01
GO:BP	GO:0009893	positive regulation of metabolic process	1	2846	4.43e-01
GO:BP	GO:0001822	kidney development	1	246	4.46e-01
GO:BP	GO:0032535	regulation of cellular component size	1	306	4.46e-01
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	1	249	4.47e-01
GO:BP	GO:0015850	organic hydroxy compound transport	1	181	4.51e-01
GO:BP	GO:0006950	response to stress	1	2763	4.51e-01
GO:BP	GO:0072001	renal system development	1	253	4.52e-01
GO:BP	GO:0051924	regulation of calcium ion transport	1	167	4.52e-01
GO:BP	GO:0048731	system development	1	2886	4.52e-01
GO:BP	GO:0042221	response to chemical	1	2456	4.53e-01
GO:BP	GO:1901990	regulation of mitotic cell cycle phase transition	1	305	4.53e-01
GO:BP	GO:0003012	muscle system process	1	334	4.53e-01
GO:BP	GO:0051234	establishment of localization	2	3453	4.55e-01
GO:BP	GO:0040011	locomotion	2	854	4.55e-01
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	1	3059	4.55e-01
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	1	3054	4.55e-01
GO:BP	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	1	189	4.56e-01
GO:BP	GO:0018130	heterocycle biosynthetic process	1	3115	4.60e-01
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	1	1203	4.60e-01
GO:BP	GO:0019438	aromatic compound biosynthetic process	1	3116	4.60e-01
GO:BP	GO:0051179	localization	4	3983	4.62e-01
GO:BP	GO:0022898	regulation of transmembrane transporter activity	1	200	4.64e-01
GO:BP	GO:0007611	learning or memory	1	201	4.64e-01
GO:BP	GO:0071705	nitrogen compound transport	1	1689	4.64e-01
GO:BP	GO:0030030	cell projection organization	1	1236	4.64e-01
GO:BP	GO:0010639	negative regulation of organelle organization	1	310	4.64e-01
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	1	3221	4.67e-01
GO:BP	GO:0098662	inorganic cation transmembrane transport	2	537	4.69e-01
GO:BP	GO:0008202	steroid metabolic process	1	203	4.69e-01
GO:BP	GO:0062012	regulation of small molecule metabolic process	1	248	4.69e-01
GO:BP	GO:0001558	regulation of cell growth	1	352	4.69e-01
GO:BP	GO:0060070	canonical Wnt signaling pathway	1	254	4.69e-01
GO:BP	GO:0019932	second-messenger-mediated signaling	1	182	4.69e-01
GO:BP	GO:0001667	ameboidal-type cell migration	1	358	4.69e-01
GO:BP	GO:0051649	establishment of localization in cell	1	1842	4.69e-01
GO:BP	GO:0032102	negative regulation of response to external stimulus	1	291	4.69e-01
GO:BP	GO:0032409	regulation of transporter activity	1	212	4.75e-01
GO:BP	GO:0098655	monoatomic cation transmembrane transport	2	554	4.77e-01
GO:BP	GO:0048511	rhythmic process	1	233	4.77e-01
GO:BP	GO:0010975	regulation of neuron projection development	1	374	4.77e-01
GO:BP	GO:0007409	axonogenesis	1	350	4.77e-01
GO:BP	GO:0032880	regulation of protein localization	1	719	4.77e-01
GO:BP	GO:0045786	negative regulation of cell cycle	1	337	4.77e-01
GO:BP	GO:0043087	regulation of GTPase activity	1	288	4.77e-01
GO:BP	GO:0030111	regulation of Wnt signaling pathway	1	274	4.80e-01
GO:BP	GO:0140694	non-membrane-bounded organelle assembly	1	364	4.80e-01
GO:BP	GO:0006935	chemotaxis	1	264	4.80e-01
GO:BP	GO:0019216	regulation of lipid metabolic process	1	251	4.80e-01
GO:BP	GO:0030001	metal ion transport	2	568	4.80e-01
GO:BP	GO:0051235	maintenance of location	1	263	4.80e-01
GO:BP	GO:0006518	peptide metabolic process	1	781	4.80e-01
GO:BP	GO:0007275	multicellular organism development	1	3355	4.80e-01
GO:BP	GO:0042330	taxis	1	264	4.80e-01
GO:BP	GO:0008104	protein localization	2	2128	4.87e-01
GO:BP	GO:0070727	cellular macromolecule localization	2	2137	4.88e-01
GO:BP	GO:0055085	transmembrane transport	3	1014	4.89e-01
GO:BP	GO:0007059	chromosome segregation	1	360	4.90e-01
GO:BP	GO:0060537	muscle tissue development	1	347	4.90e-01
GO:BP	GO:0006066	alcohol metabolic process	1	263	4.96e-01
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	1	3743	4.96e-01
GO:BP	GO:0060341	regulation of cellular localization	1	805	4.97e-01
GO:BP	GO:0009410	response to xenobiotic stimulus	1	275	4.97e-01
GO:BP	GO:0016049	cell growth	1	416	4.97e-01
GO:BP	GO:0051248	negative regulation of protein metabolic process	1	799	4.97e-01
GO:BP	GO:1901987	regulation of cell cycle phase transition	1	387	4.97e-01
GO:BP	GO:0098660	inorganic ion transmembrane transport	2	582	4.97e-01
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	1	232	4.97e-01
GO:BP	GO:0061564	axon development	1	388	4.99e-01
GO:BP	GO:0090066	regulation of anatomical structure size	1	395	4.99e-01
GO:BP	GO:0000280	nuclear division	1	343	4.99e-01
GO:BP	GO:0048585	negative regulation of response to stimulus	3	1267	5.04e-01
GO:BP	GO:0009894	regulation of catabolic process	1	883	5.04e-01
GO:BP	GO:0032501	multicellular organismal process	9	4807	5.04e-01
GO:BP	GO:0044772	mitotic cell cycle phase transition	1	411	5.04e-01
GO:BP	GO:0070588	calcium ion transmembrane transport	1	221	5.10e-01
GO:BP	GO:0016477	cell migration	2	1065	5.10e-01
GO:BP	GO:0030163	protein catabolic process	1	906	5.10e-01
GO:BP	GO:0030335	positive regulation of cell migration	1	408	5.10e-01
GO:BP	GO:1901135	carbohydrate derivative metabolic process	1	841	5.12e-01
GO:BP	GO:0051656	establishment of organelle localization	1	397	5.15e-01
GO:BP	GO:0050878	regulation of body fluid levels	1	237	5.15e-01
GO:BP	GO:0006996	organelle organization	2	2974	5.21e-01
GO:BP	GO:2000147	positive regulation of cell motility	1	421	5.25e-01
GO:BP	GO:0048856	anatomical structure development	2	4100	5.25e-01
GO:BP	GO:0048285	organelle fission	1	387	5.26e-01
GO:BP	GO:0034330	cell junction organization	1	586	5.27e-01
GO:BP	GO:0006869	lipid transport	1	271	5.27e-01
GO:BP	GO:0010468	regulation of gene expression	1	3587	5.27e-01
GO:BP	GO:0040017	positive regulation of locomotion	1	429	5.27e-01
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	1	451	5.27e-01
GO:BP	GO:0007346	regulation of mitotic cell cycle	1	438	5.27e-01
GO:BP	GO:0048523	negative regulation of cellular process	1	3773	5.27e-01
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	1	4243	5.33e-01
GO:BP	GO:0034220	monoatomic ion transmembrane transport	2	650	5.34e-01
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	1	3702	5.35e-01
GO:BP	GO:0010959	regulation of metal ion transport	1	271	5.35e-01
GO:BP	GO:0033036	macromolecule localization	1	2448	5.35e-01
GO:BP	GO:0033365	protein localization to organelle	1	860	5.38e-01
GO:BP	GO:0006812	monoatomic cation transport	2	677	5.38e-01
GO:BP	GO:0048522	positive regulation of cellular process	1	4197	5.38e-01
GO:BP	GO:0080090	regulation of primary metabolic process	1	4371	5.40e-01
GO:BP	GO:0031326	regulation of cellular biosynthetic process	1	3794	5.40e-01
GO:BP	GO:0009889	regulation of biosynthetic process	1	3820	5.41e-01
GO:BP	GO:0007264	small GTPase mediated signal transduction	1	413	5.41e-01
GO:BP	GO:0005975	carbohydrate metabolic process	1	439	5.41e-01
GO:BP	GO:0040008	regulation of growth	1	493	5.41e-01
GO:BP	GO:0043603	amide metabolic process	1	1003	5.41e-01
GO:BP	GO:0048519	negative regulation of biological process	1	4026	5.47e-01
GO:BP	GO:0198738	cell-cell signaling by wnt	1	380	5.47e-01
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	1	529	5.47e-01
GO:BP	GO:0051051	negative regulation of transport	1	317	5.47e-01
GO:BP	GO:0010876	lipid localization	1	309	5.47e-01
GO:BP	GO:0044770	cell cycle phase transition	1	496	5.47e-01
GO:BP	GO:0036211	protein modification process	1	2751	5.47e-01
GO:BP	GO:0048812	neuron projection morphogenesis	1	500	5.47e-01
GO:BP	GO:0016055	Wnt signaling pathway	1	379	5.47e-01
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	1	515	5.51e-01
GO:BP	GO:0048589	developmental growth	1	522	5.51e-01
GO:BP	GO:0031344	regulation of cell projection organization	1	542	5.51e-01
GO:BP	GO:0048858	cell projection morphogenesis	1	519	5.52e-01
GO:BP	GO:0006816	calcium ion transport	1	275	5.57e-01
GO:BP	GO:0032502	developmental process	2	4445	5.61e-01
GO:BP	GO:0032990	cell part morphogenesis	1	539	5.62e-01
GO:BP	GO:0048518	positive regulation of biological process	1	4566	5.62e-01
GO:BP	GO:0043412	macromolecule modification	1	2948	5.64e-01
GO:BP	GO:0051641	cellular localization	1	2822	5.66e-01
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	1	296	5.66e-01
GO:BP	GO:0051345	positive regulation of hydrolase activity	1	412	5.66e-01
GO:BP	GO:0051640	organelle localization	1	521	5.69e-01
GO:BP	GO:0098609	cell-cell adhesion	1	599	5.73e-01
GO:BP	GO:1901565	organonitrogen compound catabolic process	1	1151	5.73e-01
GO:BP	GO:0009057	macromolecule catabolic process	1	1215	5.80e-01
GO:BP	GO:0051276	chromosome organization	1	533	5.85e-01
GO:BP	GO:1901615	organic hydroxy compound metabolic process	1	375	5.90e-01
GO:BP	GO:0008015	blood circulation	1	372	5.90e-01
GO:BP	GO:0031323	regulation of cellular metabolic process	1	4563	5.91e-01
GO:BP	GO:0060255	regulation of macromolecule metabolic process	1	4593	5.94e-01
GO:BP	GO:0006811	monoatomic ion transport	1	788	5.97e-01
GO:BP	GO:0050877	nervous system process	1	628	5.98e-01
GO:BP	GO:0009059	macromolecule biosynthetic process	2	5148	6.01e-01
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	1	445	6.01e-01
GO:BP	GO:0009968	negative regulation of signal transduction	2	1017	6.01e-01
GO:BP	GO:0032989	cellular component morphogenesis	1	627	6.01e-01
GO:BP	GO:0016070	RNA metabolic process	1	3573	6.01e-01
GO:BP	GO:0010564	regulation of cell cycle process	1	622	6.27e-01
GO:BP	GO:0019222	regulation of metabolic process	1	4998	6.30e-01
GO:BP	GO:0043269	regulation of monoatomic ion transport	1	369	6.35e-01
GO:BP	GO:0051716	cellular response to stimulus	1	4929	6.35e-01
GO:BP	GO:0008285	negative regulation of cell population proliferation	1	643	6.35e-01
GO:BP	GO:0007420	brain development	1	546	6.35e-01
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	1	680	6.35e-01
GO:BP	GO:0032879	regulation of localization	3	1570	6.37e-01
GO:BP	GO:1903047	mitotic cell cycle process	1	689	6.37e-01
GO:BP	GO:0090304	nucleic acid metabolic process	1	4018	6.37e-01
GO:BP	GO:0034762	regulation of transmembrane transport	1	392	6.37e-01
GO:BP	GO:0023057	negative regulation of signaling	2	1090	6.42e-01
GO:BP	GO:0010648	negative regulation of cell communication	2	1088	6.42e-01
GO:BP	GO:0065003	protein-containing complex assembly	1	1320	6.44e-01
GO:BP	GO:0060322	head development	1	588	6.52e-01
GO:BP	GO:0040007	growth	1	737	6.56e-01
GO:BP	GO:0000902	cell morphogenesis	1	740	6.67e-01
GO:BP	GO:0007610	behavior	1	439	6.69e-01
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	1	4423	6.69e-01
GO:BP	GO:0031175	neuron projection development	1	774	6.78e-01
GO:BP	GO:0046483	heterocycle metabolic process	1	4537	6.81e-01
GO:BP	GO:0044249	cellular biosynthetic process	2	5813	6.82e-01
GO:BP	GO:0006725	cellular aromatic compound metabolic process	1	4561	6.83e-01
GO:BP	GO:0019752	carboxylic acid metabolic process	1	684	6.88e-01
GO:BP	GO:0071824	protein-DNA complex organization	1	711	6.88e-01
GO:BP	GO:1901576	organic substance biosynthetic process	2	5875	6.88e-01
GO:BP	GO:0043436	oxoacid metabolic process	1	699	6.93e-01
GO:BP	GO:0009058	biosynthetic process	2	5912	6.93e-01
GO:BP	GO:0006082	organic acid metabolic process	1	703	6.93e-01
GO:BP	GO:0000278	mitotic cell cycle	1	815	6.93e-01
GO:BP	GO:1901360	organic cyclic compound metabolic process	1	4713	6.93e-01
GO:BP	GO:0032101	regulation of response to external stimulus	1	690	6.94e-01
GO:BP	GO:0019538	protein metabolic process	1	4202	7.03e-01
GO:BP	GO:0009888	tissue development	2	1425	7.03e-01
GO:BP	GO:0034641	cellular nitrogen compound metabolic process	1	4913	7.03e-01
GO:BP	GO:0051241	negative regulation of multicellular organismal process	1	744	7.05e-01
GO:BP	GO:0048513	animal organ development	3	2156	7.10e-01
GO:BP	GO:1901575	organic substance catabolic process	1	1731	7.14e-01
GO:BP	GO:0007155	cell adhesion	1	996	7.15e-01
GO:BP	GO:0043933	protein-containing complex organization	1	1964	7.15e-01
GO:BP	GO:0048666	neuron development	1	873	7.15e-01
GO:BP	GO:0051336	regulation of hydrolase activity	1	680	7.20e-01
GO:BP	GO:0044281	small molecule metabolic process	2	1386	7.20e-01
GO:BP	GO:0050896	response to stimulus	1	5721	7.20e-01
GO:BP	GO:0007417	central nervous system development	1	750	7.30e-01
GO:BP	GO:0006259	DNA metabolic process	1	886	7.30e-01
GO:BP	GO:1902531	regulation of intracellular signal transduction	2	1318	7.32e-01
GO:BP	GO:0010467	gene expression	1	4733	7.32e-01
GO:BP	GO:0051246	regulation of protein metabolic process	1	1895	7.42e-01
GO:BP	GO:0023051	regulation of signaling	4	2560	7.49e-01
GO:BP	GO:0051726	regulation of cell cycle	1	941	7.50e-01
GO:BP	GO:0010646	regulation of cell communication	4	2567	7.50e-01
GO:BP	GO:0051049	regulation of transport	2	1268	7.50e-01
GO:BP	GO:0035556	intracellular signal transduction	3	2036	7.51e-01
GO:BP	GO:0048878	chemical homeostasis	1	689	7.59e-01
GO:BP	GO:0033993	response to lipid	1	594	7.60e-01
GO:BP	GO:0033043	regulation of organelle organization	1	1001	7.60e-01
GO:BP	GO:0022607	cellular component assembly	1	2459	7.60e-01
GO:BP	GO:0014070	response to organic cyclic compound	1	634	7.60e-01
GO:BP	GO:0043085	positive regulation of catalytic activity	1	815	7.60e-01
GO:BP	GO:1901564	organonitrogen compound metabolic process	1	4919	7.60e-01
GO:BP	GO:0009056	catabolic process	1	2108	7.65e-01
GO:BP	GO:0007600	sensory perception	1	259	7.70e-01
GO:BP	GO:0044092	negative regulation of molecular function	1	730	7.72e-01
GO:BP	GO:0044085	cellular component biogenesis	1	2722	7.79e-01
GO:BP	GO:0051128	regulation of cellular component organization	2	1981	7.79e-01
GO:BP	GO:0022402	cell cycle process	1	1078	7.85e-01
GO:BP	GO:0009966	regulation of signal transduction	3	2271	8.26e-01
GO:BP	GO:0006807	nitrogen compound metabolic process	2	7431	8.32e-01
GO:BP	GO:0048583	regulation of response to stimulus	4	2877	8.43e-01
GO:BP	GO:0043170	macromolecule metabolic process	2	7084	8.57e-01
GO:BP	GO:0023052	signaling	7	4134	8.57e-01
GO:BP	GO:0007186	G protein-coupled receptor signaling pathway	1	386	8.57e-01
GO:BP	GO:0044093	positive regulation of molecular function	1	1132	8.57e-01
GO:BP	GO:0006629	lipid metabolic process	1	989	8.57e-01
GO:BP	GO:0007154	cell communication	7	4210	8.69e-01
GO:BP	GO:0050794	regulation of cellular process	1	7632	8.93e-01
GO:BP	GO:0007049	cell cycle	1	1515	8.93e-01
GO:BP	GO:0044238	primary metabolic process	2	7788	8.95e-01
GO:BP	GO:0065009	regulation of molecular function	2	1905	8.99e-01
GO:BP	GO:0050790	regulation of catalytic activity	1	1349	9.03e-01
GO:BP	GO:0042592	homeostatic process	1	1189	9.05e-01
GO:BP	GO:0007166	cell surface receptor signaling pathway	2	1889	9.12e-01
GO:BP	GO:0044237	cellular metabolic process	2	7562	9.22e-01
GO:BP	GO:0050789	regulation of biological process	1	8017	9.26e-01
GO:BP	GO:0016043	cellular component organization	2	5106	9.27e-01
GO:BP	GO:1901700	response to oxygen-containing compound	1	1219	9.35e-01
GO:BP	GO:0071840	cellular component organization or biogenesis	2	5307	9.36e-01
GO:BP	GO:0065008	regulation of biological quality	2	2085	9.37e-01
GO:BP	GO:0009653	anatomical structure morphogenesis	1	1952	9.39e-01
GO:BP	GO:0009605	response to external stimulus	1	1635	9.39e-01
GO:BP	GO:0065007	biological regulation	1	8282	9.47e-01
GO:BP	GO:0007165	signal transduction	5	3803	9.55e-01
GO:BP	GO:0010033	response to organic substance	1	1942	9.90e-01
GO:BP	GO:0008150	biological_process	1	12027	1.00e+00
GO:BP	GO:0071704	organic substance metabolic process	1	8176	1.00e+00
GO:BP	GO:0008152	metabolic process	1	8522	1.00e+00
GO:BP	GO:0009987	cellular process	1	11410	1.00e+00
KEGG	KEGG:05202	Transcriptional misregulation in cancer	1	128	7.07e-02
KEGG	KEGG:05215	Prostate cancer	1	86	7.07e-02
KEGG	KEGG:00510	N-Glycan biosynthesis	1	48	7.29e-02
KEGG	KEGG:05014	Amyotrophic lateral sclerosis	1	303	1.56e-01
KEGG	KEGG:05016	Huntington disease	1	256	1.56e-01
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	1	385	1.68e-01
KEGG	KEGG:04360	Axon guidance	1	162	2.12e-01
KEGG	KEGG:04080	Neuroactive ligand-receptor interaction	1	108	4.86e-01
KEGG	KEGG:01100	Metabolic pathways	1	1146	5.69e-01
KEGG	KEGG:00000	KEGG root term	1	5548	6.01e-01

TRZnomtable24h %>%
  filter(source=="KEGG") %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "Enrichment of KEGG terms using nominal pvalue TRZ 24hour genes in my data") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

Enrichment of KEGG terms using nominal pvalue TRZ 24hour genes in my data

source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:05202	Transcriptional misregulation in cancer	1	128	7.07e-02
KEGG	KEGG:05215	Prostate cancer	1	86	7.07e-02
KEGG	KEGG:00510	N-Glycan biosynthesis	1	48	7.29e-02
KEGG	KEGG:05014	Amyotrophic lateral sclerosis	1	303	1.56e-01
KEGG	KEGG:05016	Huntington disease	1	256	1.56e-01
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	1	385	1.68e-01
KEGG	KEGG:04360	Axon guidance	1	162	2.12e-01
KEGG	KEGG:04080	Neuroactive ligand-receptor interaction	1	108	4.86e-01
KEGG	KEGG:01100	Metabolic pathways	1	1146	5.69e-01
KEGG	KEGG:00000	KEGG root term	1	5548	6.01e-01

# DAgostres3 <- readRDS("data/DEG-GO/DAgostres3.RDS")
# DAgostres24 <- readRDS("data/DAgostres24.RDS")
# DXgostres <- readRDS("data/DEG-GO/DXgostres.RDS")
# DXgostres24 <- readRDS("data/DEG-GO/DXgostres24.RDS")
# EPgostres <- readRDS("data/DEG-GO/EPgostres.RDS")
# EPgostres24 <- readRDS("data/DEG-GO/EPgostres24.RDS")
# MTgostres <- readRDS("data/DEG-GO/MTgostres.RDS")
# MTgostres24 <- readRDS("data/DEG-GO/MTgostres24.RDS")
# DDEgostres24only <- readRDS("data/DEG-GO/DDEgostres24only.RDS")
# DDEgostres3only <- readRDS("data/DEG-GO/DDEgostres3only.RDS")
# DDEMgostres3 <- readRDS("data/DEG-GO/DDEMgostres3.RDS")
# DDEMgostres24 <- readRDS("data/DEG-GO/DDEMgostres24.RDS")
# TRZresgenes24h  <- readRDS("data/DEG-GO/TRZresgenes24h.RDS") 
# TRZresgenes3h  <- readRDS("data/DEG-GO/TRZresgenes3h.RDS") 
# saveRDS(list3hr,"data/DEG-GO/list3hr.RDS")
# saveRDS(list24hr,"data/DEG-GO/list24hr.RDS")
# list3hr <- list(DAgostres3=DAgostres3,DXgostres=DXgostres,EPgostres=EPgostres,MTgostres=MTgostres,TRZresgenes3h=TRZresgenes3h,DDEgostres3only=DDEgostres3only,DDEMgostres3=DDEMgostres3)
#  list24hr <- list(DAgostres24=DAgostres24,DXgostres24=DXgostres24,EPgostres24=EPgostres24,MTgostres24=MTgostres24,TRZresgenes243h=TRZresgenes24h,DDEgostres24only=DDEgostres24only,DDEMgostres24=DDEMgostres24)

list3hr <- readRDS("data/DEG-GO/list3hr.RDS")
list24hr <- readRDS("data/DEG-GO/list24hr.RDS")
KEGGtrz3 <- c("KEGG:05202", "KEGG:04115", "KEGG:05223", "KEGG:05212","KEGG:05222")
KEGGtrz24 <- c("KEGG:05202", "KEGG:05215", "KEGG:00510")
# testframe <- lapply(list3hr, `[`,'result')

hr3_results <- list3hr |> 
  map(~ .x$result |> dplyr::select(p_value,term_id,term_name,intersection_size))
hr24_results <- list24hr |> 
  map(~ .x$result |> dplyr::select(p_value,term_id,term_name,,intersection_size))

table_3hr <- list_rbind(hr3_results,names_to = "set")%>%
  mutate(log_val = -log10(p_value)) %>% 
  dplyr::filter(term_id %in% KEGGtrz3) %>% 
  mutate(treatment = case_when(set =="DAgostres3"~"DNR",set=="DXgostres" ~ "DOX",set=="EPgostres"~"EPI",set=="MTgostres"~"MTX",set=="TRZresgenes3h"~"TRZ",set=="DDEgostres23only"~"AC",set=="DDEMgostres3"~"TOP2i"))


table_24hr <- list_rbind(hr24_results,names_to = "set") %>%
  mutate(log_val = -log10(p_value))%>% 
  dplyr::filter(term_id %in% KEGGtrz24) %>% 
  mutate(treatment = case_when(set =="DAgostres24"~"DNR",set=="DXgostres24" ~ "DOX",set=="EPgostres24"~"EPI",set=="MTgostres24"~"MTX",set=="TRZresgenes243h"~"TRZ",set=="DDEgostres24only"~"AC",set=="DDEMgostres24"~"TOP2i"))


hr3_results[["TRZresgenes3h"]]  %>% 
    mutate(log_val = -log10(p_value)) %>% 
  dplyr::filter(str_detect(term_id,"^KEGG:")) %>% 
  slice_min(., n=5,order_by=p_value) %>%
    ggplot(., aes(x = log_val, y =reorder(term_name,p_value),col=intersection_size)) +
    geom_point(aes(size = intersection_size)) +
    scale_y_discrete(labels = scales::label_wrap(30))+
  geom_vline(xintercept = (-log10(0.05)), col="red")+
    guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
    ggtitle('TRZ 3 hour nominal DE\n KEGG pathway enrichment') +
    xlab(expression(" -"~log[10]~("nominal p-value")))+
    ylab("KEGG")+
    theme_bw()+
    theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
        axis.title = element_text(size = 15, color = "black"),
        axis.ticks = element_line(linewidth = 1.5),
        # axis.line = element_line(linewidth = 1.5),
        axis.text = element_text(size = 10, color = "black", angle = 0),
        strip.text.x = element_text(size = 12, color = "black", face = "bold"))

hr24_results[["TRZresgenes243h"]]  %>% 
    mutate(log_val = -log10(p_value)) %>% 
  dplyr::filter(str_detect(term_id,"^KEGG:")) %>% 
  slice_min(., n=5,order_by=p_value) %>%
    ggplot(., aes(x = log_val, y =reorder(term_name,p_value), col=intersection_size)) +
    geom_point(aes(size = intersection_size)) +
    scale_y_discrete(labels = scales::label_wrap(30))+
   geom_vline(xintercept = (-log10(0.05)), col="red")+
    guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
    ggtitle('TRZ 24 hour nominal DE\n KEGG pathway enrichment') +
    xlab(expression(" -"~log[10]~("nominal p-value")))+
    ylab("KEGG")+
    theme_bw()+
    theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
        axis.title = element_text(size = 15, color = "black"),
        axis.ticks = element_line(linewidth = 1.5),
        # axis.line = element_line(linewidth = 1.5),
        axis.text = element_text(size = 10, color = "black", angle = 0),
        strip.text.x = element_text(size = 12, color = "black", face = "bold"))

hr3_results[["TRZresgenes3h"]]  %>% 
    mutate(log_val = -log10(p_value)) %>% 
  dplyr::filter(str_detect(term_id,"^GO:")) %>% 
  slice_min(., n=5,order_by=p_value) %>%
    ggplot(., aes(x = log_val, y =reorder(term_name,p_value),col=intersection_size)) +
    geom_point(aes(size = intersection_size)) +
    scale_y_discrete(labels = scales::label_wrap(30))+
  geom_vline(xintercept = (-log10(0.05)), col="red")+
    guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
    ggtitle('TRZ 3 hour nominal DE\n GO:BP enrichment') +
    xlab(expression(" -"~log[10]~("nominal p-value")))+
    ylab("KEGG")+
    theme_bw()+
    theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
        axis.title = element_text(size = 15, color = "black"),
        axis.ticks = element_line(linewidth = 1.5),
        axis.line = element_line(linewidth = 1.5),
        axis.text = element_text(size = 10, color = "black", angle = 0),
        strip.text.x = element_text(size = 12, color = "black", face = "bold"))

hr24_results[["TRZresgenes243h"]]  %>% 
    mutate(log_val = -log10(p_value)) %>% 
  dplyr::filter(str_detect(term_id,"^GO:")) %>% 
  slice_min(., n=4,order_by=p_value) %>%
    ggplot(., aes(x = log_val, y =reorder(term_name,p_value), col=intersection_size)) +
    geom_point(aes(size = intersection_size)) +
    scale_y_discrete(labels = scales::label_wrap(30))+
  geom_vline(xintercept = (-log10(0.05)), col="red")+
    guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
    ggtitle('TRZ 24 hour nominal DE\n GO:BP enrichment') +
    xlab(expression(" -"~log[10]~("nominal p-value")))+
    ylab("KEGG")+
    theme_bw()+
    theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
        axis.title = element_text(size = 15, color = "black"),
        axis.ticks = element_line(linewidth = 1.5),
        # axis.line = element_line(linewidth = 1.5),
        axis.text = element_text(size = 10, color = "black", angle = 0),
        strip.text.x = element_text(size = 12, color = "black", face = "bold"))

Link to other pages here:

Knowles and troponin

Other analysis aka after_comments data here

Session information

sessionInfo()

R version 4.3.1 (2023-06-16 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)

Matrix products: default


locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

time zone: America/Chicago
tzcode source: internal

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] qvalue_2.32.0      gprofiler2_0.2.2   RColorBrewer_1.1-3 biomaRt_2.56.1    
 [5] broom_1.0.5        kableExtra_1.3.4   sjmisc_2.8.9       scales_1.2.1      
 [9] ggpubr_0.6.0       cowplot_1.1.1      ggsignif_0.6.4     lubridate_1.9.3   
[13] forcats_1.0.0      stringr_1.5.0      dplyr_1.1.3        purrr_1.0.2       
[17] readr_2.1.4        tidyr_1.3.0        tibble_3.2.1       ggplot2_3.4.4     
[21] tidyverse_2.0.0    workflowr_1.7.1   

loaded via a namespace (and not attached):
  [1] rstudioapi_0.15.0       jsonlite_1.8.7          magrittr_2.0.3         
  [4] farver_2.1.1            rmarkdown_2.25          fs_1.6.3               
  [7] zlibbioc_1.46.0         vctrs_0.6.4             memoise_2.0.1          
 [10] RCurl_1.98-1.13         rstatix_0.7.2           webshot_0.5.5          
 [13] htmltools_0.5.7         progress_1.2.2          curl_5.1.0             
 [16] sass_0.4.7              bslib_0.5.1             htmlwidgets_1.6.2      
 [19] plyr_1.8.9              plotly_4.10.3           cachem_1.0.8           
 [22] whisker_0.4.1           mime_0.12               lifecycle_1.0.4        
 [25] pkgconfig_2.0.3         sjlabelled_1.2.0        R6_2.5.1               
 [28] fastmap_1.1.1           shiny_1.7.5.1           GenomeInfoDbData_1.2.10
 [31] digest_0.6.33           colorspace_2.1-0        AnnotationDbi_1.62.2   
 [34] S4Vectors_0.38.2        ps_1.7.5                rprojroot_2.0.4        
 [37] crosstalk_1.2.0         RSQLite_2.3.3           filelock_1.0.2         
 [40] labeling_0.4.3          fansi_1.0.5             timechange_0.2.0       
 [43] httr_1.4.7              abind_1.4-5             compiler_4.3.1         
 [46] bit64_4.0.5             withr_2.5.2             backports_1.4.1        
 [49] carData_3.0-5           DBI_1.1.3               highr_0.10             
 [52] rappdirs_0.3.3          tools_4.3.1             httpuv_1.6.12          
 [55] glue_1.6.2              callr_3.7.3             promises_1.2.1         
 [58] grid_4.3.1              getPass_0.2-2           reshape2_1.4.4         
 [61] generics_0.1.3          gtable_0.3.4            tzdb_0.4.0             
 [64] data.table_1.14.8       hms_1.1.3               xml2_1.3.5             
 [67] car_3.1-2               utf8_1.2.4              XVector_0.40.0         
 [70] BiocGenerics_0.46.0     pillar_1.9.0            vroom_1.6.4            
 [73] later_1.3.1             splines_4.3.1           BiocFileCache_2.8.0    
 [76] bit_4.0.5               tidyselect_1.2.0        Biostrings_2.68.1      
 [79] knitr_1.45              git2r_0.32.0            IRanges_2.34.1         
 [82] svglite_2.1.2           stats4_4.3.1            xfun_0.41              
 [85] Biobase_2.60.0          stringi_1.7.12          lazyeval_0.2.2         
 [88] yaml_2.3.7              evaluate_0.23           cli_3.6.1              
 [91] xtable_1.8-4            systemfonts_1.0.5       munsell_0.5.0          
 [94] processx_3.8.2          jquerylib_0.1.4         Rcpp_1.0.11            
 [97] GenomeInfoDb_1.36.4     dbplyr_2.3.4            png_0.1-8              
[100] XML_3.99-0.15           parallel_4.3.1          ellipsis_0.3.2         
[103] blob_1.2.4              prettyunits_1.2.0       bitops_1.0-7           
[106] viridisLite_0.4.2       insight_0.19.6          crayon_1.5.2           
[109] rlang_1.1.2             KEGGREST_1.40.1         rvest_1.0.3