Last updated: 2023-04-20

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Knit directory: Cardiotoxicity/

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GO Analysis

I have created several files from the RNA analysis that contain the significant genes(determined by adj.P.val < 0.05) from each Time and Condition. The names of the files are in the following format: ‘sigV’+Drug(2 letters)+time.

example: ‘sigVDA3.txt’ means this file contains the significant DE genes from the Daunorubicin 3 hour compared to Vehicle Control 3 hour analysis

<environment: R_GlobalEnv>

The analysis is based on all genes that passed the rowMeans>0 from the previous page which are about 14084 genes expressed in my RNA-seq data link

All analysis is completed with an adjusted p value of 0.05 This is updated from the 0.1 value I had been using.

2023-04-19 RM

Knowels, et al. mentioned a relationship between transcriptional change level indicating cardiotoxicity. This may be an observation that supports that claim as well. ## Daunorubicin

This is analysis on the significantly differentially expressed genes for Daunorubicin by 3 and 24 hours.

source term_id term_name intersection_size term_size p_value
GO:BP GO:0006357 regulation of transcription by RNA polymerase II 217 1915 1.99e-34
GO:BP GO:0006366 transcription by RNA polymerase II 222 1991 1.99e-34
GO:BP GO:0006351 DNA-templated transcription 258 2683 1.58e-31
GO:BP GO:0097659 nucleic acid-templated transcription 258 2684 1.58e-31
GO:BP GO:1903506 regulation of nucleic acid-templated transcription 251 2581 6.94e-31
GO:BP GO:0006355 regulation of DNA-templated transcription 251 2579 6.94e-31
GO:BP GO:0032774 RNA biosynthetic process 258 2714 6.94e-31
GO:BP GO:0051252 regulation of RNA metabolic process 267 2849 7.48e-31
GO:BP GO:2001141 regulation of RNA biosynthetic process 251 2598 1.71e-30
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 280 3105 4.11e-30
GO:BP GO:0010556 regulation of macromolecule biosynthetic process 263 3015 1.45e-26
GO:BP GO:0031326 regulation of cellular biosynthetic process 264 3123 4.18e-24
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 261 3083 8.83e-24
GO:BP GO:0009889 regulation of biosynthetic process 265 3174 1.97e-23
GO:BP GO:0018130 heterocycle biosynthetic process 263 3148 2.58e-23
GO:BP GO:0019438 aromatic compound biosynthetic process 262 3149 9.91e-23
GO:BP GO:1901362 organic cyclic compound biosynthetic process 265 3253 1.60e-21
GO:BP GO:0009059 macromolecule biosynthetic process 279 3730 6.11e-19
GO:BP GO:0031323 regulation of cellular metabolic process 310 4305 1.87e-18
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 306 4330 4.67e-16
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 273 3758 7.50e-16
GO:BP GO:0080090 regulation of primary metabolic process 311 4440 8.59e-16
GO:BP GO:0000122 negative regulation of transcription by RNA polymerase II 90 735 1.46e-14
GO:BP GO:0045892 negative regulation of DNA-templated transcription 104 1009 3.12e-12
GO:BP GO:1903507 negative regulation of nucleic acid-templated transcription 104 1011 3.31e-12
GO:BP GO:0051253 negative regulation of RNA metabolic process 110 1115 5.72e-12
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 104 1020 6.16e-12
GO:BP GO:0044249 cellular biosynthetic process 292 4465 4.95e-11
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 113 1215 1.07e-10
GO:BP GO:0010468 regulation of gene expression 279 3583 2.05e-10
GO:BP GO:1901576 organic substance biosynthetic process 293 4537 2.29e-10
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 109 1206 7.83e-10
GO:BP GO:0009058 biosynthetic process 304 4595 1.41e-09
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 109 1249 7.68e-09
GO:BP GO:0051254 positive regulation of RNA metabolic process 121 1431 1.41e-08
GO:BP GO:0045893 positive regulation of DNA-templated transcription 114 1304 1.71e-08
GO:BP GO:1903508 positive regulation of nucleic acid-templated transcription 114 1304 1.71e-08
GO:BP GO:0009890 negative regulation of biosynthetic process 109 1273 2.14e-08
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 114 1311 2.14e-08
GO:BP GO:0031324 negative regulation of cellular metabolic process 136 1780 7.22e-08
GO:BP GO:0010557 positive regulation of macromolecule biosynthetic process 123 1499 3.42e-07
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 126 1600 3.63e-07
GO:BP GO:0060255 regulation of macromolecule metabolic process 225 4640 5.26e-07
GO:BP GO:0031328 positive regulation of cellular biosynthetic process 126 1571 1.17e-06
GO:BP GO:0045944 positive regulation of transcription by RNA polymerase II 72 925 2.18e-06
GO:BP GO:0009891 positive regulation of biosynthetic process 126 1598 3.59e-06
GO:BP GO:0019222 regulation of metabolic process 228 5039 5.48e-06
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 134 1866 1.59e-05
GO:BP GO:0031325 positive regulation of cellular metabolic process 118 2373 9.70e-05
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 163 2425 1.54e-04
GO:BP GO:0060411 cardiac septum morphogenesis 11 67 2.82e-04
GO:BP GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 21 229 3.51e-04
GO:BP GO:0003281 ventricular septum development 11 69 4.15e-04
GO:BP GO:0140467 integrated stress response signaling 6 34 4.85e-04
GO:BP GO:0003007 heart morphogenesis 19 212 8.67e-04
GO:BP GO:0030510 regulation of BMP signaling pathway 5 84 1.73e-03
GO:BP GO:0019827 stem cell population maintenance 12 150 2.02e-03
GO:BP GO:0098727 maintenance of cell number 12 152 2.48e-03
GO:BP GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 13 126 2.85e-03
GO:BP GO:0003279 cardiac septum development 12 101 2.99e-03
GO:BP GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 13 127 3.46e-03
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 171 2648 4.04e-03
GO:BP GO:0002320 lymphoid progenitor cell differentiation 5 17 4.37e-03
GO:BP GO:0018076 N-terminal peptidyl-lysine acetylation 3 4 4.49e-03
GO:BP GO:0003181 atrioventricular valve morphogenesis 5 24 4.94e-03
GO:BP GO:0003162 atrioventricular node development 3 8 5.55e-03
GO:BP GO:0003151 outflow tract morphogenesis 9 66 5.81e-03
GO:BP GO:0060840 artery development 11 82 6.07e-03
GO:BP GO:0030853 negative regulation of granulocyte differentiation 2 6 6.11e-03
GO:BP GO:0006473 protein acetylation 15 208 7.40e-03
GO:BP GO:0021915 neural tube development 16 146 7.42e-03
GO:BP GO:0060412 ventricular septum morphogenesis 7 40 7.72e-03
GO:BP GO:0003171 atrioventricular valve development 5 26 7.99e-03
GO:BP GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 12 99 8.33e-03
GO:BP GO:0043009 chordate embryonic development 41 531 8.33e-03
GO:BP GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 22 301 9.12e-03
GO:BP GO:0030509 BMP signaling pathway 5 123 9.12e-03
GO:BP GO:0007179 transforming growth factor beta receptor signaling pathway 15 177 9.29e-03
GO:BP GO:0045659 negative regulation of neutrophil differentiation 1 2 9.29e-03
GO:BP GO:0045645 positive regulation of eosinophil differentiation 1 1 9.29e-03
GO:BP GO:0045643 regulation of eosinophil differentiation 1 1 9.29e-03
GO:BP GO:0003183 mitral valve morphogenesis 3 10 1.02e-02
GO:BP GO:0002244 hematopoietic progenitor cell differentiation 11 109 1.04e-02
GO:BP GO:0071772 response to BMP 5 131 1.13e-02
GO:BP GO:0060430 lung saccule development 2 7 1.13e-02
GO:BP GO:0071773 cellular response to BMP stimulus 5 131 1.13e-02
GO:BP GO:0090425 acinar cell differentiation 3 5 1.14e-02
GO:BP GO:1902893 regulation of miRNA transcription 5 51 1.19e-02
GO:BP GO:0010944 negative regulation of transcription by competitive promoter binding 2 8 1.19e-02
GO:BP GO:0009893 positive regulation of metabolic process 122 2884 1.19e-02
GO:BP GO:0045658 regulation of neutrophil differentiation 1 2 1.19e-02
GO:BP GO:1902459 positive regulation of stem cell population maintenance 8 44 1.19e-02
GO:BP GO:0061614 miRNA transcription 5 52 1.19e-02
GO:BP GO:0007507 heart development 40 502 1.19e-02
GO:BP GO:0001841 neural tube formation 10 101 1.19e-02
GO:BP GO:0003174 mitral valve development 3 11 1.19e-02
GO:BP GO:0009792 embryo development ending in birth or egg hatching 41 548 1.27e-02
GO:BP GO:0090304 nucleic acid metabolic process 14 4047 1.35e-02
GO:BP GO:0090287 regulation of cellular response to growth factor stimulus 19 263 1.35e-02
GO:BP GO:0018394 peptidyl-lysine acetylation 13 180 1.35e-02
GO:BP GO:0001657 ureteric bud development 4 75 1.36e-02
GO:BP GO:0016070 RNA metabolic process 102 3593 1.36e-02
GO:BP GO:2001020 regulation of response to DNA damage stimulus 25 292 1.36e-02
GO:BP GO:0072163 mesonephric epithelium development 4 76 1.36e-02
GO:BP GO:0036499 PERK-mediated unfolded protein response 4 17 1.36e-02
GO:BP GO:0072164 mesonephric tubule development 4 76 1.36e-02
GO:BP GO:0048738 cardiac muscle tissue development 18 198 1.48e-02
GO:BP GO:0045927 positive regulation of growth 5 200 1.53e-02
GO:BP GO:0060419 heart growth 10 72 1.53e-02
GO:BP GO:0001823 mesonephros development 4 77 1.53e-02
GO:BP GO:0071559 response to transforming growth factor beta 17 224 1.56e-02
GO:BP GO:0030852 regulation of granulocyte differentiation 2 11 1.60e-02
GO:BP GO:0002065 columnar/cuboidal epithelial cell differentiation 8 79 1.63e-02
GO:BP GO:0030222 eosinophil differentiation 1 2 1.63e-02
GO:BP GO:0002763 positive regulation of myeloid leukocyte differentiation 2 34 1.63e-02
GO:BP GO:0014706 striated muscle tissue development 20 210 1.70e-02
GO:BP GO:0003179 heart valve morphogenesis 5 50 1.72e-02
GO:BP GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 2 12 1.80e-02
GO:BP GO:0003310 pancreatic A cell differentiation 2 2 1.84e-02
GO:BP GO:0030514 negative regulation of BMP signaling pathway 3 45 1.85e-02
GO:BP GO:2000628 regulation of miRNA metabolic process 5 62 1.88e-02
GO:BP GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 2 4 1.92e-02
GO:BP GO:0034616 response to laminar fluid shear stress 3 14 1.92e-02
GO:BP GO:0002328 pro-B cell differentiation 3 10 2.07e-02
GO:BP GO:0003148 outflow tract septum morphogenesis 3 23 2.13e-02
GO:BP GO:0003206 cardiac chamber morphogenesis 7 109 2.18e-02
GO:BP GO:0048639 positive regulation of developmental growth 4 125 2.19e-02
GO:BP GO:0014020 primary neural tube formation 9 94 2.19e-02
GO:BP GO:0030854 positive regulation of granulocyte differentiation 1 5 2.31e-02
GO:BP GO:0043543 protein acylation 15 246 2.39e-02
GO:BP GO:0055017 cardiac muscle tissue growth 9 65 2.39e-02
GO:BP GO:0048844 artery morphogenesis 8 57 2.41e-02
GO:BP GO:2000736 regulation of stem cell differentiation 10 74 2.44e-02
GO:BP GO:0051890 regulation of cardioblast differentiation 3 7 2.44e-02
GO:BP GO:1900034 regulation of cellular response to heat 4 16 2.44e-02
GO:BP GO:0003231 cardiac ventricle development 11 114 2.52e-02
GO:BP GO:0060420 regulation of heart growth 8 50 2.52e-02
GO:BP GO:0045445 myoblast differentiation 12 89 2.60e-02
GO:BP GO:0030223 neutrophil differentiation 1 8 2.68e-02
GO:BP GO:0006139 nucleobase-containing compound metabolic process 14 4503 2.69e-02
GO:BP GO:0071560 cellular response to transforming growth factor beta stimulus 16 219 2.71e-02
GO:BP GO:0035910 ascending aorta morphogenesis 2 4 2.71e-02
GO:BP GO:0010665 regulation of cardiac muscle cell apoptotic process 4 34 2.71e-02
GO:BP GO:0048538 thymus development 6 35 2.85e-02
GO:BP GO:2000036 regulation of stem cell population maintenance 6 62 2.85e-02
GO:BP GO:0043627 response to estrogen 3 51 2.85e-02
GO:BP GO:0070848 response to growth factor 32 567 2.85e-02
GO:BP GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 3 10 2.90e-02
GO:BP GO:0003170 heart valve development 5 57 2.93e-02
GO:BP GO:0045597 positive regulation of cell differentiation 4 619 2.93e-02
GO:BP GO:0003215 cardiac right ventricle morphogenesis 4 17 2.93e-02
GO:BP GO:1902894 negative regulation of miRNA transcription 2 17 2.99e-02
GO:BP GO:0060395 SMAD protein signal transduction 5 65 3.01e-02
GO:BP GO:1904290 negative regulation of mitotic DNA damage checkpoint 1 1 3.11e-02
GO:BP GO:0035264 multicellular organism growth 12 121 3.11e-02
GO:BP GO:0001838 embryonic epithelial tube formation 10 116 3.11e-02
GO:BP GO:0060038 cardiac muscle cell proliferation 7 44 3.14e-02
GO:BP GO:0010660 regulation of muscle cell apoptotic process 5 57 3.14e-02
GO:BP GO:0035904 aorta development 7 49 3.14e-02
GO:BP GO:0046483 heterocycle metabolic process 14 4616 3.14e-02
GO:BP GO:2000629 negative regulation of miRNA metabolic process 2 18 3.14e-02
GO:BP GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway 1 7 3.14e-02
GO:BP GO:0010659 cardiac muscle cell apoptotic process 4 36 3.14e-02
GO:BP GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 4 39 3.14e-02
GO:BP GO:0010662 regulation of striated muscle cell apoptotic process 4 37 3.14e-02
GO:BP GO:0055025 positive regulation of cardiac muscle tissue development 1 2 3.14e-02
GO:BP GO:0010586 miRNA metabolic process 5 76 3.23e-02
GO:BP GO:0006725 cellular aromatic compound metabolic process 14 4646 3.29e-02
GO:BP GO:0045639 positive regulation of myeloid cell differentiation 2 67 3.29e-02
GO:BP GO:0019935 cyclic-nucleotide-mediated signaling 2 55 3.30e-02
GO:BP GO:0080135 regulation of cellular response to stress 42 631 3.32e-02
GO:BP GO:1903674 regulation of cap-dependent translational initiation 1 1 3.43e-02
GO:BP GO:1903676 positive regulation of cap-dependent translational initiation 1 1 3.43e-02
GO:BP GO:0045651 positive regulation of macrophage differentiation 1 12 3.43e-02
GO:BP GO:0060043 regulation of cardiac muscle cell proliferation 6 32 3.44e-02
GO:BP GO:0032526 response to retinoic acid 4 85 3.44e-02
GO:BP GO:1901532 regulation of hematopoietic progenitor cell differentiation 5 34 3.48e-02
GO:BP GO:0072073 kidney epithelium development 4 112 3.48e-02
GO:BP GO:0002761 regulation of myeloid leukocyte differentiation 3 77 3.48e-02
GO:BP GO:0003289 atrial septum primum morphogenesis 2 5 3.52e-02
GO:BP GO:0003284 septum primum development 2 5 3.52e-02
GO:BP GO:0035905 ascending aorta development 2 5 3.52e-02
GO:BP GO:0010657 muscle cell apoptotic process 5 60 3.58e-02
GO:BP GO:0010658 striated muscle cell apoptotic process 4 39 3.73e-02
GO:BP GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 3 18 3.78e-02
GO:BP GO:0042789 mRNA transcription by RNA polymerase II 5 42 3.78e-02
GO:BP GO:0032909 regulation of transforming growth factor beta2 production 2 9 3.80e-02
GO:BP GO:0032906 transforming growth factor beta2 production 2 9 3.80e-02
GO:BP GO:0034405 response to fluid shear stress 5 31 3.80e-02
GO:BP GO:0045661 regulation of myoblast differentiation 9 60 3.87e-02
GO:BP GO:0048636 positive regulation of muscle organ development 1 3 4.05e-02
GO:BP GO:0016573 histone acetylation 11 165 4.05e-02
GO:BP GO:0045844 positive regulation of striated muscle tissue development 1 3 4.05e-02
GO:BP GO:0035909 aorta morphogenesis 5 25 4.06e-02
GO:BP GO:0010720 positive regulation of cell development 3 316 4.06e-02
GO:BP GO:0003159 morphogenesis of an endothelium 4 14 4.06e-02
GO:BP GO:0001843 neural tube closure 8 90 4.06e-02
GO:BP GO:0045622 regulation of T-helper cell differentiation 3 20 4.06e-02
GO:BP GO:2000320 negative regulation of T-helper 17 cell differentiation 2 6 4.06e-02
GO:BP GO:0045603 positive regulation of endothelial cell differentiation 1 8 4.06e-02
GO:BP GO:0061154 endothelial tube morphogenesis 4 14 4.06e-02
GO:BP GO:0061008 hepaticobiliary system development 13 109 4.06e-02
GO:BP GO:0055021 regulation of cardiac muscle tissue growth 7 45 4.06e-02
GO:BP GO:1901360 organic cyclic compound metabolic process 14 4790 4.06e-02
GO:BP GO:0030513 positive regulation of BMP signaling pathway 5 34 4.06e-02
GO:BP GO:0071363 cellular response to growth factor stimulus 30 547 4.06e-02
GO:BP GO:0072175 epithelial tube formation 12 127 4.06e-02
GO:BP GO:0008285 negative regulation of cell population proliferation 8 510 4.08e-02
GO:BP GO:1902106 negative regulation of leukocyte differentiation 3 63 4.08e-02
GO:BP GO:0006984 ER-nucleus signaling pathway 5 46 4.08e-02
GO:BP GO:0043620 regulation of DNA-templated transcription in response to stress 4 44 4.08e-02
GO:BP GO:0060010 Sertoli cell fate commitment 1 1 4.08e-02
GO:BP GO:0033484 cellular nitric oxide homeostasis 1 3 4.08e-02
GO:BP GO:0045649 regulation of macrophage differentiation 1 17 4.08e-02
GO:BP GO:0002067 glandular epithelial cell differentiation 3 49 4.08e-02
GO:BP GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus 5 29 4.08e-02
GO:BP GO:0060606 tube closure 8 91 4.08e-02
GO:BP GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway 5 29 4.08e-02
GO:BP GO:0061626 pharyngeal arch artery morphogenesis 2 10 4.08e-02
GO:BP GO:0051891 positive regulation of cardioblast differentiation 2 6 4.11e-02
GO:BP GO:2000121 regulation of removal of superoxide radicals 2 6 4.20e-02
GO:BP GO:0010656 negative regulation of muscle cell apoptotic process 6 36 4.22e-02
GO:BP GO:1903707 negative regulation of hemopoiesis 3 67 4.26e-02
GO:BP GO:0003205 cardiac chamber development 4 149 4.26e-02
GO:BP GO:0001568 blood vessel development 33 534 4.26e-02
GO:BP GO:0014912 negative regulation of smooth muscle cell migration 1 24 4.26e-02
GO:BP GO:0018393 internal peptidyl-lysine acetylation 11 169 4.26e-02
GO:BP GO:2000317 negative regulation of T-helper 17 type immune response 2 7 4.26e-02
GO:BP GO:0046620 regulation of organ growth 9 70 4.29e-02
GO:BP GO:0060487 lung epithelial cell differentiation 2 18 4.29e-02
GO:BP GO:0060479 lung cell differentiation 2 18 4.29e-02
GO:BP GO:0072739 response to anisomycin 2 4 4.29e-02
GO:BP GO:0035019 somatic stem cell population maintenance 7 50 4.29e-02
GO:BP GO:0033137 negative regulation of peptidyl-serine phosphorylation 2 26 4.29e-02
GO:BP GO:0030851 granulocyte differentiation 2 26 4.36e-02
GO:BP GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 1 15 4.41e-02
GO:BP GO:0010002 cardioblast differentiation 4 17 4.41e-02
GO:BP GO:0006475 internal protein amino acid acetylation 11 171 4.41e-02
GO:BP GO:0035265 organ growth 13 129 4.43e-02
GO:BP GO:0010667 negative regulation of cardiac muscle cell apoptotic process 3 22 4.43e-02
GO:BP GO:0034641 cellular nitrogen compound metabolic process 14 4991 4.44e-02
GO:BP GO:0007613 memory 2 90 4.45e-02
GO:BP GO:1900246 positive regulation of RIG-I signaling pathway 3 7 4.52e-02
GO:BP GO:0071300 cellular response to retinoic acid 4 49 4.62e-02
GO:BP GO:1903043 positive regulation of chondrocyte hypertrophy 1 1 4.70e-02
GO:BP GO:1903041 regulation of chondrocyte hypertrophy 1 1 4.70e-02
GO:BP GO:0060575 intestinal epithelial cell differentiation 3 17 4.70e-02
GO:BP GO:0031018 endocrine pancreas development 4 31 4.73e-02
GO:BP GO:1904003 negative regulation of sebum secreting cell proliferation 1 1 4.75e-02
GO:BP GO:0060413 atrial septum morphogenesis 3 15 4.75e-02
GO:BP GO:0006282 regulation of DNA repair 17 197 4.75e-02
GO:BP GO:0090288 negative regulation of cellular response to growth factor stimulus 3 81 4.80e-02
GO:BP GO:0009299 mRNA transcription 5 47 4.86e-02
GO:BP GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 8 90 4.91e-02
GO:BP GO:0019184 nonribosomal peptide biosynthetic process 3 15 4.91e-02
GO:BP GO:0045210 FasL biosynthetic process 1 1 4.95e-02
GO:BP GO:2000737 negative regulation of stem cell differentiation 5 24 4.97e-02
KEGG KEGG:05168 Herpes simplex virus 1 infection 66 415 5.18e-17

Daunorubicin specific genes at 3 hours

How they may relate to 24 hour genes using GO analysis

3 hours specifically (see venn below too):

All Daun DEGs adj p value < 0.05

source term_id term_name intersection_size term_size p_value
GO:BP GO:0097659 nucleic acid-templated transcription 137 2684 7.33e-10
GO:BP GO:0006366 transcription by RNA polymerase II 112 1991 7.33e-10
GO:BP GO:0006351 DNA-templated transcription 137 2683 7.33e-10
GO:BP GO:0006357 regulation of transcription by RNA polymerase II 108 1915 7.33e-10
GO:BP GO:0032774 RNA biosynthetic process 137 2714 1.01e-09
GO:BP GO:1903506 regulation of nucleic acid-templated transcription 132 2581 1.45e-09
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 148 3105 1.45e-09
GO:BP GO:0006355 regulation of DNA-templated transcription 132 2579 1.45e-09
GO:BP GO:0051252 regulation of RNA metabolic process 140 2849 1.45e-09
GO:BP GO:2001141 regulation of RNA biosynthetic process 132 2598 1.94e-09
GO:BP GO:0010556 regulation of macromolecule biosynthetic process 149 3015 1.91e-08
GO:BP GO:0031326 regulation of cellular biosynthetic process 144 3123 1.78e-07
GO:BP GO:0009889 regulation of biosynthetic process 145 3174 2.65e-07
GO:BP GO:0018130 heterocycle biosynthetic process 141 3148 5.35e-07
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 139 3083 5.35e-07
GO:BP GO:0019438 aromatic compound biosynthetic process 140 3149 1.17e-06
GO:BP GO:1901362 organic cyclic compound biosynthetic process 143 3253 1.63e-06
GO:BP GO:0009059 macromolecule biosynthetic process 150 3730 1.24e-05
GO:BP GO:0031323 regulation of cellular metabolic process 169 4305 1.24e-05
GO:BP GO:0140467 integrated stress response signaling 4 34 5.91e-04
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 145 3758 5.91e-04
GO:BP GO:0000122 negative regulation of transcription by RNA polymerase II 43 735 9.74e-04
GO:BP GO:0080090 regulation of primary metabolic process 166 4440 1.17e-03
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 162 4330 1.46e-03
GO:BP GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 3 18 2.72e-03
GO:BP GO:0044249 cellular biosynthetic process 167 4465 3.49e-03
GO:BP GO:1901576 organic substance biosynthetic process 168 4537 5.88e-03
GO:BP GO:0034599 cellular response to oxidative stress 6 239 7.97e-03
GO:BP GO:0045893 positive regulation of DNA-templated transcription 65 1304 7.97e-03
GO:BP GO:1903508 positive regulation of nucleic acid-templated transcription 65 1304 7.97e-03
GO:BP GO:2001020 regulation of response to DNA damage stimulus 19 292 7.97e-03
GO:BP GO:0009058 biosynthetic process 169 4595 7.97e-03
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 65 1311 8.55e-03
GO:BP GO:0010557 positive regulation of macromolecule biosynthetic process 71 1499 1.00e-02
GO:BP GO:0031328 positive regulation of cellular biosynthetic process 74 1571 1.00e-02
GO:BP GO:2000121 regulation of removal of superoxide radicals 2 6 1.02e-02
GO:BP GO:0051253 negative regulation of RNA metabolic process 53 1115 1.02e-02
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 55 1215 1.28e-02
GO:BP GO:0045892 negative regulation of DNA-templated transcription 49 1009 1.29e-02
GO:BP GO:1903507 negative regulation of nucleic acid-templated transcription 49 1011 1.31e-02
GO:BP GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 3 39 1.39e-02
GO:BP GO:0009891 positive regulation of biosynthetic process 71 1598 1.55e-02
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 49 1020 1.57e-02
GO:BP GO:0062197 cellular response to chemical stress 6 290 1.62e-02
GO:BP GO:0051254 positive regulation of RNA metabolic process 67 1431 1.77e-02
GO:BP GO:0036499 PERK-mediated unfolded protein response 3 17 1.77e-02
GO:BP GO:0043620 regulation of DNA-templated transcription in response to stress 3 44 1.84e-02
GO:BP GO:2000377 regulation of reactive oxygen species metabolic process 5 107 1.99e-02
GO:BP GO:0010632 regulation of epithelial cell migration 5 195 2.15e-02
GO:BP GO:0034614 cellular response to reactive oxygen species 4 121 3.66e-02
GO:BP GO:0002244 hematopoietic progenitor cell differentiation 4 109 4.11e-02
GO:BP GO:0010634 positive regulation of epithelial cell migration 4 132 4.22e-02
GO:BP GO:0006979 response to oxidative stress 6 349 4.73e-02
KEGG KEGG:05168 Herpes simplex virus 1 infection 35 415 2.97e-07
[1] 351

Interestingly, Over half of the daunorubicin specific genes are in the Daunorucin 24 hour group.

When I look at those 187 genes, I do not see a significant enrichment in GO:BP terms, only the KEGG pathway connection to Herpes simplex virus

###Daunorubicin 24 sigDEG

Looking at the Daunorubicin 24 hour geneset using adj. P value of 0.05, I have enrichment in the terms cell cycle and chromosome segregation.

source term_id term_name intersection_size term_size p_value
GO:BP GO:0000278 mitotic cell cycle 196 833 1.44e-05
GO:BP GO:0000070 mitotic sister chromatid segregation 47 193 2.30e-05
GO:BP GO:0000819 sister chromatid segregation 71 234 2.30e-05
GO:BP GO:0045930 negative regulation of mitotic cell cycle 77 208 2.30e-05
GO:BP GO:1903047 mitotic cell cycle process 163 700 8.44e-05
GO:BP GO:0007059 chromosome segregation 124 378 8.70e-05
GO:BP GO:0051301 cell division 143 567 8.70e-05

###Daunorubicin 3 v 24 intersection

All 187 3 hour Daun-specific genes are in the 304 genes between the two full lists of daunorubicin sigDEGs for 3 hours and 24 hours. This could possibly support the idea that Daunorubicin’s more toxic effect is related to earlier impacts on cell function. Note the enriched go terms for the 304 genes that they share. I need to see if there is a trend in EP and DX. I do see in Mito 3 hour (looked a little later).

[1] 7115

[1] 187
source term_id term_name intersection_size term_size p_value
GO:BP GO:0006357 regulation of transcription by RNA polymerase II 112 1915 7.05e-14
GO:BP GO:0006366 transcription by RNA polymerase II 113 1991 2.30e-13
GO:BP GO:1903506 regulation of nucleic acid-templated transcription 126 2581 1.13e-10
GO:BP GO:0006355 regulation of DNA-templated transcription 126 2579 1.13e-10
GO:BP GO:0097659 nucleic acid-templated transcription 128 2684 1.23e-10
GO:BP GO:0051252 regulation of RNA metabolic process 133 2849 1.23e-10
GO:BP GO:2001141 regulation of RNA biosynthetic process 126 2598 1.23e-10
GO:BP GO:0006351 DNA-templated transcription 128 2683 1.23e-10
GO:BP GO:0032774 RNA biosynthetic process 128 2714 2.39e-10
GO:BP GO:0010556 regulation of macromolecule biosynthetic process 101 3015 7.57e-10
GO:BP GO:0031326 regulation of cellular biosynthetic process 102 3123 3.16e-09
GO:BP GO:0009889 regulation of biosynthetic process 103 3174 3.16e-09
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 101 3105 5.02e-09
GO:BP GO:0000122 negative regulation of transcription by RNA polymerase II 52 735 1.23e-08
GO:BP GO:0018130 heterocycle biosynthetic process 99 3148 6.87e-08
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 97 3083 1.33e-07
GO:BP GO:0019438 aromatic compound biosynthetic process 98 3149 1.81e-07
GO:BP GO:1901362 organic cyclic compound biosynthetic process 100 3253 2.18e-07
GO:BP GO:0009059 macromolecule biosynthetic process 107 3730 4.29e-07
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 106 3758 2.33e-06
GO:BP GO:1903507 negative regulation of nucleic acid-templated transcription 44 1011 4.37e-06
GO:BP GO:0045892 negative regulation of DNA-templated transcription 44 1009 4.37e-06
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 44 1020 5.49e-06
GO:BP GO:0051253 negative regulation of RNA metabolic process 60 1115 5.49e-06
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 119 4330 6.97e-06
GO:BP GO:0031323 regulation of cellular metabolic process 118 4305 6.97e-06
GO:BP GO:0080090 regulation of primary metabolic process 121 4440 8.39e-06
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 47 1206 1.69e-05
GO:BP GO:0044249 cellular biosynthetic process 114 4465 4.04e-05
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 47 1249 4.84e-05
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 46 1215 6.86e-05
GO:BP GO:0009890 negative regulation of biosynthetic process 47 1273 7.96e-05
GO:BP GO:1901576 organic substance biosynthetic process 114 4537 9.44e-05
GO:BP GO:0010468 regulation of gene expression 109 3583 1.30e-04
GO:BP GO:0009058 biosynthetic process 114 4595 2.14e-04
GO:BP GO:0031324 negative regulation of cellular metabolic process 58 1780 7.01e-04
GO:BP GO:0003007 heart morphogenesis 14 212 8.69e-04
GO:BP GO:0003162 atrioventricular node development 3 8 1.31e-03
GO:BP GO:0045944 positive regulation of transcription by RNA polymerase II 35 925 1.58e-03
GO:BP GO:0048738 cardiac muscle tissue development 14 198 1.79e-03
GO:BP GO:0051254 positive regulation of RNA metabolic process 45 1431 2.89e-03
GO:BP GO:0014706 striated muscle tissue development 15 210 3.64e-03
GO:BP GO:0060411 cardiac septum morphogenesis 7 67 3.64e-03
GO:BP GO:0045893 positive regulation of DNA-templated transcription 61 1304 4.13e-03
GO:BP GO:1903508 positive regulation of nucleic acid-templated transcription 61 1304 4.13e-03
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 42 1311 4.49e-03
GO:BP GO:0031328 positive regulation of cellular biosynthetic process 48 1571 4.98e-03
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 69 2425 5.07e-03
GO:BP GO:0031325 positive regulation of cellular metabolic process 68 2373 5.16e-03
GO:BP GO:0010557 positive regulation of macromolecule biosynthetic process 46 1499 5.40e-03
GO:BP GO:0009891 positive regulation of biosynthetic process 48 1598 7.49e-03
GO:BP GO:0051890 regulation of cardioblast differentiation 3 7 9.36e-03
GO:BP GO:0003310 pancreatic A cell differentiation 2 2 1.18e-02
GO:BP GO:0060255 regulation of macromolecule metabolic process 123 4640 1.22e-02
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 56 1866 1.34e-02
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 46 1600 1.35e-02
GO:BP GO:0060412 ventricular septum morphogenesis 5 40 1.41e-02
GO:BP GO:0055017 cardiac muscle tissue growth 7 65 1.46e-02
GO:BP GO:1902894 negative regulation of miRNA transcription 2 17 2.11e-02
GO:BP GO:0003197 endocardial cushion development 5 42 2.25e-02
GO:BP GO:2000629 negative regulation of miRNA metabolic process 2 18 2.27e-02
GO:BP GO:0045622 regulation of T-helper cell differentiation 3 20 2.29e-02
GO:BP GO:0002067 glandular epithelial cell differentiation 3 49 2.43e-02
GO:BP GO:0003281 ventricular septum development 6 69 2.54e-02
GO:BP GO:0060575 intestinal epithelial cell differentiation 3 17 2.54e-02
GO:BP GO:0045927 positive regulation of growth 4 200 2.54e-02
GO:BP GO:0060419 heart growth 7 72 2.56e-02
GO:BP GO:0043009 chordate embryonic development 22 531 2.69e-02
GO:BP GO:0032906 transforming growth factor beta2 production 3 9 2.69e-02
GO:BP GO:0002065 columnar/cuboidal epithelial cell differentiation 6 79 2.69e-02
GO:BP GO:0032909 regulation of transforming growth factor beta2 production 3 9 2.69e-02
GO:BP GO:0019184 nonribosomal peptide biosynthetic process 3 15 2.69e-02
GO:BP GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 8 99 2.69e-02
GO:BP GO:0003279 cardiac septum development 5 101 2.69e-02
GO:BP GO:0007507 heart development 25 502 2.69e-02
GO:BP GO:0048645 animal organ formation 7 52 2.69e-02
GO:BP GO:0060038 cardiac muscle cell proliferation 5 44 2.69e-02
GO:BP GO:0051891 positive regulation of cardioblast differentiation 2 6 2.78e-02
GO:BP GO:0035051 cardiocyte differentiation 9 129 2.78e-02
GO:BP GO:0003151 outflow tract morphogenesis 6 66 2.78e-02
GO:BP GO:2000121 regulation of removal of superoxide radicals 2 6 2.85e-02
GO:BP GO:2000320 negative regulation of T-helper 17 cell differentiation 2 6 2.85e-02
GO:BP GO:0071773 cellular response to BMP stimulus 6 131 3.00e-02
GO:BP GO:0071772 response to BMP 6 131 3.00e-02
GO:BP GO:0061626 pharyngeal arch artery morphogenesis 2 10 3.00e-02
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 68 2648 3.17e-02
GO:BP GO:2000317 negative regulation of T-helper 17 type immune response 2 7 3.18e-02
GO:BP GO:0009792 embryo development ending in birth or egg hatching 22 548 3.41e-02
GO:BP GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation 3 27 3.54e-02
GO:BP GO:0045603 positive regulation of endothelial cell differentiation 1 8 3.59e-02
GO:BP GO:0001657 ureteric bud development 3 75 3.90e-02
GO:BP GO:0072163 mesonephric epithelium development 3 76 3.93e-02
GO:BP GO:0072164 mesonephric tubule development 3 76 3.93e-02
GO:BP GO:0019222 regulation of metabolic process 123 5039 3.95e-02
GO:BP GO:0060010 Sertoli cell fate commitment 1 1 4.11e-02
GO:BP GO:0001823 mesonephros development 3 77 4.11e-02
GO:BP GO:0030510 regulation of BMP signaling pathway 3 84 4.11e-02
GO:BP GO:0014916 regulation of lung blood pressure 2 3 4.11e-02
GO:BP GO:0009893 positive regulation of metabolic process 71 2884 4.11e-02
GO:BP GO:0003206 cardiac chamber morphogenesis 5 109 4.11e-02
GO:BP GO:0019827 stem cell population maintenance 7 150 4.19e-02
GO:BP GO:0030336 negative regulation of cell migration 9 227 4.25e-02
GO:BP GO:0033484 cellular nitric oxide homeostasis 1 3 4.25e-02
GO:BP GO:0060914 heart formation 3 30 4.25e-02
GO:BP GO:0098727 maintenance of cell number 7 152 4.59e-02
GO:BP GO:0030307 positive regulation of cell growth 3 136 4.80e-02
GO:BP GO:1903041 regulation of chondrocyte hypertrophy 1 1 4.80e-02
GO:BP GO:1903043 positive regulation of chondrocyte hypertrophy 1 1 4.80e-02
GO:BP GO:0035265 organ growth 9 129 4.80e-02
GO:BP GO:0003161 cardiac conduction system development 4 34 4.80e-02
GO:BP GO:0045210 FasL biosynthetic process 1 1 4.80e-02
GO:BP GO:0048844 artery morphogenesis 5 57 4.82e-02
GO:BP GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 12 229 4.83e-02
GO:BP GO:0035886 vascular associated smooth muscle cell differentiation 2 27 4.83e-02
GO:BP GO:1904003 negative regulation of sebum secreting cell proliferation 1 1 4.83e-02
GO:BP GO:0042093 T-helper cell differentiation 3 38 4.83e-02
GO:BP GO:0001701 in utero embryonic development 17 342 4.84e-02
GO:BP GO:0048639 positive regulation of developmental growth 3 125 4.84e-02
GO:BP GO:0030513 positive regulation of BMP signaling pathway 4 34 4.84e-02
KEGG KEGG:05168 Herpes simplex virus 1 infection 32 415 1.21e-06

##Doxorubicin 3 hour and 24 hour

source term_id term_name intersection_size term_size p_value
GO:BP GO:1904290 negative regulation of mitotic DNA damage checkpoint 1 1 4.04e-02
GO:BP GO:1900036 positive regulation of cellular response to heat 1 1 4.04e-02
GO:BP GO:1904289 regulation of mitotic DNA damage checkpoint 1 3 4.04e-02
source term_id term_name intersection_size term_size p_value
GO:BP GO:0000278 mitotic cell cycle 179 833 6.42e-10
GO:BP GO:1903047 mitotic cell cycle process 172 700 4.38e-09
GO:BP GO:0000070 mitotic sister chromatid segregation 66 193 4.38e-09
GO:BP GO:0000819 sister chromatid segregation 75 234 6.53e-09
GO:BP GO:0007059 chromosome segregation 103 378 1.54e-08
GO:BP GO:0045930 negative regulation of mitotic cell cycle 65 208 3.49e-08
GO:BP GO:0140014 mitotic nuclear division 50 264 3.49e-08
GO:BP GO:0007093 mitotic cell cycle checkpoint signaling 47 136 5.75e-08
GO:BP GO:0010564 regulation of cell cycle process 89 620 6.11e-08
GO:BP GO:0051301 cell division 138 567 1.04e-07
GO:BP GO:0000075 cell cycle checkpoint signaling 55 180 2.95e-07
GO:BP GO:0051276 chromosome organization 89 543 1.02e-06
GO:BP GO:0051726 regulation of cell cycle 135 950 1.98e-06
GO:BP GO:0000280 nuclear division 93 354 2.14e-06
GO:BP GO:0022402 cell cycle process 208 1075 2.70e-06
GO:BP GO:0098813 nuclear chromosome segregation 84 287 2.70e-06
GO:BP GO:0007051 spindle organization 50 186 4.37e-06
GO:BP GO:0007052 mitotic spindle organization 29 128 5.58e-06
GO:BP GO:1902850 microtubule cytoskeleton organization involved in mitosis 52 156 5.63e-06
GO:BP GO:0051988 regulation of attachment of spindle microtubules to kinetochore 11 18 7.10e-06
GO:BP GO:0007346 regulation of mitotic cell cycle 105 438 7.10e-06
GO:BP GO:1905818 regulation of chromosome separation 28 69 7.10e-06
GO:BP GO:1901988 negative regulation of cell cycle phase transition 63 232 7.10e-06
GO:BP GO:0051225 spindle assembly 31 118 7.10e-06
GO:BP GO:0008608 attachment of spindle microtubules to kinetochore 19 42 7.74e-06
GO:BP GO:0048285 organelle fission 97 397 9.81e-06
GO:BP GO:0051983 regulation of chromosome segregation 39 118 1.12e-05
GO:BP GO:0007080 mitotic metaphase plate congression 17 55 1.31e-05
GO:BP GO:0045786 negative regulation of cell cycle 84 334 1.63e-05
GO:BP GO:0007049 cell cycle 193 1522 1.72e-05
GO:BP GO:0010948 negative regulation of cell cycle process 69 270 2.11e-05
GO:BP GO:2001251 negative regulation of chromosome organization 40 90 2.87e-05
GO:BP GO:0051231 spindle elongation 9 12 2.87e-05
GO:BP GO:0033047 regulation of mitotic sister chromatid segregation 16 52 2.91e-05
GO:BP GO:0090068 positive regulation of cell cycle process 56 206 2.91e-05
GO:BP GO:0051304 chromosome separation 28 74 3.23e-05
GO:BP GO:0051256 mitotic spindle midzone assembly 8 9 3.36e-05
GO:BP GO:0006974 cellular response to DNA damage stimulus 151 789 4.69e-05
GO:BP GO:1903490 positive regulation of mitotic cytokinesis 7 7 5.07e-05
GO:BP GO:0045839 negative regulation of mitotic nuclear division 22 54 5.22e-05
GO:BP GO:0030071 regulation of mitotic metaphase/anaphase transition 30 88 5.72e-05
GO:BP GO:0045841 negative regulation of mitotic metaphase/anaphase transition 20 46 6.12e-05
GO:BP GO:0051310 metaphase plate congression 18 69 6.14e-05
GO:BP GO:0006261 DNA-templated DNA replication 60 149 6.14e-05
GO:BP GO:0007094 mitotic spindle assembly checkpoint signaling 14 44 6.15e-05
GO:BP GO:0071174 mitotic spindle checkpoint signaling 14 44 6.15e-05
GO:BP GO:0071173 spindle assembly checkpoint signaling 14 44 6.15e-05
GO:BP GO:0007088 regulation of mitotic nuclear division 35 100 6.36e-05
GO:BP GO:0044774 mitotic DNA integrity checkpoint signaling 30 82 6.42e-05
GO:BP GO:1901991 negative regulation of mitotic cell cycle phase transition 46 163 6.70e-05
GO:BP GO:0000022 mitotic spindle elongation 8 10 6.85e-05
GO:BP GO:0010965 regulation of mitotic sister chromatid separation 23 58 7.27e-05
GO:BP GO:0031577 spindle checkpoint signaling 14 45 7.30e-05
GO:BP GO:0000226 microtubule cytoskeleton organization 108 552 8.81e-05
GO:BP GO:1901987 regulation of cell cycle phase transition 52 388 8.96e-05
GO:BP GO:1902099 regulation of metaphase/anaphase transition of cell cycle 30 89 9.05e-05
GO:BP GO:0007091 metaphase/anaphase transition of mitotic cell cycle 30 91 9.05e-05
GO:BP GO:0033046 negative regulation of sister chromatid segregation 20 47 9.17e-05
GO:BP GO:0033048 negative regulation of mitotic sister chromatid segregation 20 47 9.17e-05
GO:BP GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 20 47 9.17e-05
GO:BP GO:2000816 negative regulation of mitotic sister chromatid separation 20 47 9.17e-05
GO:BP GO:0033045 regulation of sister chromatid segregation 32 99 1.09e-04
GO:BP GO:0031570 DNA integrity checkpoint signaling 37 126 1.11e-04
GO:BP GO:1901990 regulation of mitotic cell cycle phase transition 73 305 1.17e-04
GO:BP GO:1902412 regulation of mitotic cytokinesis 8 8 1.20e-04
GO:BP GO:0051315 attachment of mitotic spindle microtubules to kinetochore 10 21 1.21e-04
GO:BP GO:0051984 positive regulation of chromosome segregation 11 25 1.42e-04
GO:BP GO:0032465 regulation of cytokinesis 30 79 1.46e-04
GO:BP GO:0051306 mitotic sister chromatid separation 23 61 1.46e-04
GO:BP GO:0044784 metaphase/anaphase transition of cell cycle 30 92 1.55e-04
GO:BP GO:0051985 negative regulation of chromosome segregation 20 48 1.60e-04
GO:BP GO:1905819 negative regulation of chromosome separation 20 48 1.60e-04
GO:BP GO:0051783 regulation of nuclear division 25 115 1.60e-04
GO:BP GO:0044772 mitotic cell cycle phase transition 93 413 1.68e-04
GO:BP GO:0006281 DNA repair 77 535 1.76e-04
GO:BP GO:0006541 glutamine metabolic process 4 23 2.23e-04
GO:BP GO:0006260 DNA replication 116 258 2.32e-04
GO:BP GO:0051255 spindle midzone assembly 8 12 2.35e-04
GO:BP GO:0044770 cell cycle phase transition 108 499 2.35e-04
GO:BP GO:0051784 negative regulation of nuclear division 22 57 2.66e-04
GO:BP GO:0044773 mitotic DNA damage checkpoint signaling 26 78 2.86e-04
GO:BP GO:0050000 chromosome localization 19 82 2.87e-04
GO:BP GO:0090307 mitotic spindle assembly 16 69 2.98e-04
GO:BP GO:0000077 DNA damage checkpoint signaling 33 118 3.40e-04
GO:BP GO:0051303 establishment of chromosome localization 18 75 3.52e-04
GO:BP GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore 7 11 3.78e-04
GO:BP GO:0000281 mitotic cytokinesis 26 81 4.53e-04
GO:BP GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore 6 8 4.91e-04
GO:BP GO:1902423 regulation of attachment of mitotic spindle microtubules to kinetochore 6 8 4.91e-04
GO:BP GO:0046037 GMP metabolic process 4 24 5.40e-04
GO:BP GO:0006270 DNA replication initiation 12 35 5.40e-04
GO:BP GO:0010212 response to ionizing radiation 41 130 6.35e-04
GO:BP GO:0007017 microtubule-based process 139 756 7.82e-04
GO:BP GO:0060236 regulation of mitotic spindle organization 8 42 9.20e-04
GO:BP GO:0006167 AMP biosynthetic process 3 14 9.44e-04
GO:BP GO:0006177 GMP biosynthetic process 3 14 1.17e-03
GO:BP GO:0033044 regulation of chromosome organization 72 233 1.69e-03
GO:BP GO:0090224 regulation of spindle organization 8 45 1.71e-03
GO:BP GO:1902117 positive regulation of organelle assembly 17 75 1.83e-03
GO:BP GO:0045787 positive regulation of cell cycle 64 278 1.93e-03
GO:BP GO:0042770 signal transduction in response to DNA damage 41 173 2.45e-03
GO:BP GO:0046060 dATP metabolic process 2 3 2.79e-03
GO:BP GO:0009167 purine ribonucleoside monophosphate metabolic process 4 40 3.31e-03
GO:BP GO:0051383 kinetochore organization 15 23 3.46e-03
GO:BP GO:0009126 purine nucleoside monophosphate metabolic process 4 42 3.86e-03
GO:BP GO:0061640 cytoskeleton-dependent cytokinesis 29 103 3.91e-03
GO:BP GO:0007098 centrosome cycle 31 126 3.96e-03
GO:BP GO:0009168 purine ribonucleoside monophosphate biosynthetic process 3 22 3.97e-03
GO:BP GO:1905820 positive regulation of chromosome separation 12 26 4.56e-03
GO:BP GO:0071478 cellular response to radiation 36 155 4.60e-03
GO:BP GO:0000086 G2/M transition of mitotic cell cycle 38 134 4.75e-03
GO:BP GO:0009127 purine nucleoside monophosphate biosynthetic process 3 24 4.91e-03
GO:BP GO:0046033 AMP metabolic process 3 22 4.91e-03
GO:BP GO:0010389 regulation of G2/M transition of mitotic cell cycle 29 92 5.48e-03
GO:BP GO:0000910 cytokinesis 44 163 5.71e-03
GO:BP GO:0051302 regulation of cell division 26 144 6.29e-03
GO:BP GO:0045005 DNA-templated DNA replication maintenance of fidelity 24 50 7.05e-03
GO:BP GO:0090235 regulation of metaphase plate congression 7 13 7.05e-03
GO:BP GO:0071479 cellular response to ionizing radiation 23 68 7.06e-03
GO:BP GO:0030510 regulation of BMP signaling pathway 3 84 7.35e-03
GO:BP GO:0000731 DNA synthesis involved in DNA repair 11 36 7.68e-03
GO:BP GO:0044209 AMP salvage 2 5 7.68e-03
GO:BP GO:0032263 GMP salvage 2 4 7.68e-03
GO:BP GO:0009262 deoxyribonucleotide metabolic process 23 38 7.86e-03
GO:BP GO:0019692 deoxyribose phosphate metabolic process 23 38 7.86e-03
GO:BP GO:0031023 microtubule organizing center organization 27 136 8.40e-03
GO:BP GO:0104004 cellular response to environmental stimulus 54 264 8.47e-03
GO:BP GO:0071214 cellular response to abiotic stimulus 54 264 8.47e-03
GO:BP GO:0044839 cell cycle G2/M phase transition 40 148 8.47e-03
GO:BP GO:0046601 positive regulation of centriole replication 6 9 9.00e-03
GO:BP GO:0033554 cellular response to stress 270 1677 9.16e-03
GO:BP GO:0006979 response to oxidative stress 34 349 1.01e-02
GO:BP GO:0009411 response to UV 18 137 1.06e-02
GO:BP GO:0000076 DNA replication checkpoint signaling 10 15 1.12e-02
GO:BP GO:0042542 response to hydrogen peroxide 15 103 1.17e-02
GO:BP GO:0000302 response to reactive oxygen species 20 160 1.17e-02
GO:BP GO:0010332 response to gamma radiation 19 50 1.17e-02
GO:BP GO:0009394 2’-deoxyribonucleotide metabolic process 22 37 1.18e-02
GO:BP GO:0009161 ribonucleoside monophosphate metabolic process 4 56 1.18e-02
GO:BP GO:0044786 cell cycle DNA replication 19 40 1.23e-02
GO:BP GO:0009064 glutamine family amino acid metabolic process 4 61 1.23e-02
GO:BP GO:0023019 signal transduction involved in regulation of gene expression 2 14 1.31e-02
GO:BP GO:0140694 non-membrane-bounded organelle assembly 23 355 1.31e-02
GO:BP GO:0010639 negative regulation of organelle organization 25 318 1.32e-02
GO:BP GO:0046053 dAMP metabolic process 2 5 1.35e-02
GO:BP GO:0009215 purine deoxyribonucleoside triphosphate metabolic process 2 7 1.35e-02
GO:BP GO:1900262 regulation of DNA-directed DNA polymerase activity 11 13 1.37e-02
GO:BP GO:1900264 positive regulation of DNA-directed DNA polymerase activity 11 13 1.37e-02
GO:BP GO:0009156 ribonucleoside monophosphate biosynthetic process 6 36 1.43e-02
GO:BP GO:0009314 response to radiation 67 349 1.47e-02
GO:BP GO:0009112 nucleobase metabolic process 3 27 1.47e-02
GO:BP GO:0032467 positive regulation of cytokinesis 15 33 1.55e-02
GO:BP GO:0090232 positive regulation of spindle checkpoint 6 12 1.56e-02
GO:BP GO:0009200 deoxyribonucleoside triphosphate metabolic process 3 9 1.56e-02
GO:BP GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint 6 12 1.56e-02
GO:BP GO:0007143 female meiotic nuclear division 11 25 1.58e-02
GO:BP GO:0019985 translesion synthesis 10 24 1.58e-02
GO:BP GO:0033043 regulation of organelle organization 75 1023 1.58e-02
GO:BP GO:0106380 purine ribonucleotide salvage 2 7 1.65e-02
GO:BP GO:0006271 DNA strand elongation involved in DNA replication 12 15 1.68e-02
GO:BP GO:0030509 BMP signaling pathway 3 123 1.88e-02
GO:BP GO:0099625 ventricular cardiac muscle cell membrane repolarization 6 21 1.91e-02
GO:BP GO:0030174 regulation of DNA-templated DNA replication initiation 7 14 1.94e-02
GO:BP GO:1902969 mitotic DNA replication 9 14 1.95e-02
GO:BP GO:0006301 postreplication repair 12 34 1.97e-02
GO:BP GO:0071773 cellular response to BMP stimulus 3 131 2.20e-02
GO:BP GO:0071772 response to BMP 3 131 2.20e-02
GO:BP GO:0031573 mitotic intra-S DNA damage checkpoint signaling 4 15 2.20e-02
GO:BP GO:0031297 replication fork processing 20 42 2.20e-02
GO:BP GO:0006284 base-excision repair 10 44 2.23e-02
GO:BP GO:0010032 meiotic chromosome condensation 4 6 2.26e-02
GO:BP GO:0040001 establishment of mitotic spindle localization 15 36 2.31e-02
GO:BP GO:0086067 AV node cell to bundle of His cell communication 4 11 2.32e-02
GO:BP GO:1905832 positive regulation of spindle assembly 5 7 2.32e-02
GO:BP GO:1903046 meiotic cell cycle process 47 136 2.35e-02
GO:BP GO:0044818 mitotic G2/M transition checkpoint 17 50 2.35e-02
GO:BP GO:1902115 regulation of organelle assembly 29 186 2.35e-02
GO:BP GO:0071480 cellular response to gamma radiation 12 29 2.35e-02
GO:BP GO:0009170 purine deoxyribonucleoside monophosphate metabolic process 2 7 2.35e-02
GO:BP GO:0009123 nucleoside monophosphate metabolic process 4 71 2.40e-02
GO:BP GO:0046599 regulation of centriole replication 9 21 2.50e-02
GO:BP GO:0046602 regulation of mitotic centrosome separation 5 8 2.52e-02
GO:BP GO:0042148 strand invasion 4 5 2.56e-02
GO:BP GO:1902749 regulation of cell cycle G2/M phase transition 29 102 2.56e-02
GO:BP GO:0009124 nucleoside monophosphate biosynthetic process 3 44 2.58e-02
GO:BP GO:1901976 regulation of cell cycle checkpoint 10 45 2.65e-02
GO:BP GO:0046129 purine ribonucleoside biosynthetic process 2 11 2.71e-02
GO:BP GO:0042455 ribonucleoside biosynthetic process 2 11 2.71e-02
GO:BP GO:0042451 purine nucleoside biosynthetic process 2 11 2.71e-02
GO:BP GO:0032261 purine nucleotide salvage 2 10 2.71e-02
GO:BP GO:0034644 cellular response to UV 19 83 2.72e-02
GO:BP GO:0006259 DNA metabolic process 108 890 2.76e-02
GO:BP GO:0006175 dATP biosynthetic process 1 1 2.85e-02
GO:BP GO:0030330 DNA damage response, signal transduction by p53 class mediator 8 68 2.87e-02
GO:BP GO:0038202 TORC1 signaling 39 56 3.01e-02
GO:BP GO:0140013 meiotic nuclear division 40 121 3.08e-02
GO:BP GO:0070925 organelle assembly 141 803 3.08e-02
GO:BP GO:2000233 negative regulation of rRNA processing 3 3 3.08e-02
GO:BP GO:0035878 nail development 2 7 3.11e-02
GO:BP GO:0006290 pyrimidine dimer repair 1 7 3.21e-02
GO:BP GO:0090329 regulation of DNA-templated DNA replication 28 54 3.31e-02
GO:BP GO:1905821 positive regulation of chromosome condensation 4 5 3.36e-02
GO:BP GO:0007079 mitotic chromosome movement towards spindle pole 3 4 3.36e-02
GO:BP GO:1901978 positive regulation of cell cycle checkpoint 7 19 3.39e-02
GO:BP GO:0033260 nuclear DNA replication 6 35 3.46e-02
GO:BP GO:0098869 cellular oxidant detoxification 6 66 3.46e-02
GO:BP GO:0032508 DNA duplex unwinding 19 75 3.59e-02
GO:BP GO:0034502 protein localization to chromosome 19 110 3.68e-02
GO:BP GO:0036166 phenotypic switching 4 7 3.74e-02
GO:BP GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 19 60 3.80e-02
GO:BP GO:0090071 negative regulation of ribosome biogenesis 4 5 3.89e-02
GO:BP GO:0006268 DNA unwinding involved in DNA replication 10 22 3.89e-02
GO:BP GO:0071459 protein localization to chromosome, centromeric region 9 42 3.89e-02
GO:BP GO:1903432 regulation of TORC1 signaling 33 46 3.89e-02
GO:BP GO:0098880 maintenance of postsynaptic specialization structure 6 7 3.92e-02
GO:BP GO:0007076 mitotic chromosome condensation 12 19 4.00e-02
GO:BP GO:0086012 membrane depolarization during cardiac muscle cell action potential 5 21 4.05e-02
GO:BP GO:0006275 regulation of DNA replication 42 124 4.05e-02
GO:BP GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization 5 16 4.05e-02
GO:BP GO:0051299 centrosome separation 9 14 4.17e-02
GO:BP GO:0061642 chemoattraction of axon 2 2 4.29e-02
GO:BP GO:0009163 nucleoside biosynthetic process 2 15 4.33e-02
GO:BP GO:0034404 nucleobase-containing small molecule biosynthetic process 2 15 4.33e-02
GO:BP GO:0043101 purine-containing compound salvage 2 14 4.33e-02
GO:BP GO:0008315 G2/MI transition of meiotic cell cycle 4 5 4.33e-02
GO:BP GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 4 16 4.36e-02
GO:BP GO:0036462 TRAIL-activated apoptotic signaling pathway 6 10 4.37e-02
GO:BP GO:0085020 protein K6-linked ubiquitination 6 9 4.41e-02
GO:BP GO:0038101 sequestering of nodal from receptor via nodal binding 1 1 4.41e-02
GO:BP GO:0036480 neuron intrinsic apoptotic signaling pathway in response to oxidative stress 5 8 4.59e-02
GO:BP GO:1903376 regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway 5 8 4.59e-02
GO:BP GO:0009202 deoxyribonucleoside triphosphate biosynthetic process 1 2 4.67e-02
GO:BP GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors 22 72 4.67e-02
GO:BP GO:0032506 cytokinetic process 12 39 4.67e-02
GO:BP GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 6 43 4.67e-02
GO:BP GO:0009216 purine deoxyribonucleoside triphosphate biosynthetic process 1 2 4.67e-02
GO:BP GO:0016321 female meiosis chromosome segregation 3 5 4.69e-02
GO:BP GO:0036297 interstrand cross-link repair 12 37 4.95e-02
GO:BP GO:0070914 UV-damage excision repair 1 13 4.99e-02
KEGG KEGG:04115 p53 signaling pathway 16 65 6.55e-07
KEGG KEGG:03410 Base excision repair 25 33 2.25e-04
KEGG KEGG:03030 DNA replication 15 35 2.25e-04
KEGG KEGG:03430 Mismatch repair 17 22 3.93e-03
KEGG KEGG:04110 Cell cycle 15 121 3.93e-03
KEGG KEGG:03440 Homologous recombination 13 39 4.07e-03
KEGG KEGG:01524 Platinum drug resistance 22 65 1.00e-02
KEGG KEGG:05322 Systemic lupus erythematosus 2 61 1.19e-02
KEGG KEGG:04217 Necroptosis 2 106 1.58e-02
KEGG KEGG:05034 Alcoholism 2 122 1.79e-02
KEGG KEGG:04613 Neutrophil extracellular trap formation 2 110 1.79e-02
KEGG KEGG:03460 Fanconi anemia pathway 14 48 3.30e-02
KEGG KEGG:04964 Proximal tubule bicarbonate reclamation 2 20 3.34e-02

Epirubicin

All Epi DEGs adj p value < 0.05

source term_id term_name intersection_size term_size p_value
GO:BP GO:0006357 regulation of transcription by RNA polymerase II 108 1915 5.92e-24
GO:BP GO:0006366 transcription by RNA polymerase II 109 1991 1.85e-23
GO:BP GO:1903506 regulation of nucleic acid-templated transcription 120 2581 8.86e-21
GO:BP GO:0097659 nucleic acid-templated transcription 122 2684 8.86e-21
GO:BP GO:0006351 DNA-templated transcription 122 2683 8.86e-21
GO:BP GO:0006355 regulation of DNA-templated transcription 120 2579 8.86e-21
GO:BP GO:2001141 regulation of RNA biosynthetic process 120 2598 1.07e-20
GO:BP GO:0032774 RNA biosynthetic process 122 2714 1.75e-20
GO:BP GO:0051252 regulation of RNA metabolic process 125 2849 2.55e-20
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 129 3105 2.00e-19
GO:BP GO:0010556 regulation of macromolecule biosynthetic process 124 3015 6.72e-18
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 124 3083 3.98e-17
GO:BP GO:0031326 regulation of cellular biosynthetic process 124 3123 1.91e-16
GO:BP GO:0018130 heterocycle biosynthetic process 124 3148 1.91e-16
GO:BP GO:0019438 aromatic compound biosynthetic process 124 3149 2.26e-16
GO:BP GO:0009889 regulation of biosynthetic process 124 3174 6.91e-16
GO:BP GO:1901362 organic cyclic compound biosynthetic process 124 3253 4.32e-15
GO:BP GO:0009059 macromolecule biosynthetic process 131 3730 4.48e-14
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 144 4330 1.54e-13
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 130 3758 4.49e-13
GO:BP GO:0080090 regulation of primary metabolic process 145 4440 6.75e-13
GO:BP GO:0031323 regulation of cellular metabolic process 141 4305 1.21e-12
GO:BP GO:0010468 regulation of gene expression 131 3583 2.93e-09
GO:BP GO:0000122 negative regulation of transcription by RNA polymerase II 43 735 7.73e-09
GO:BP GO:0044249 cellular biosynthetic process 125 4465 1.81e-08
GO:BP GO:0045892 negative regulation of DNA-templated transcription 50 1009 4.90e-08
GO:BP GO:1903507 negative regulation of nucleic acid-templated transcription 50 1011 4.98e-08
GO:BP GO:1901576 organic substance biosynthetic process 125 4537 5.54e-08
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 50 1020 6.71e-08
GO:BP GO:0009058 biosynthetic process 125 4595 1.58e-07
GO:BP GO:0060255 regulation of macromolecule metabolic process 146 4640 2.72e-07
GO:BP GO:0051253 negative regulation of RNA metabolic process 51 1115 3.20e-07
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 53 1206 6.42e-07
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 53 1249 2.27e-06
GO:BP GO:0009890 negative regulation of biosynthetic process 53 1273 4.22e-06
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 51 1215 4.79e-06
GO:BP GO:0051254 positive regulation of RNA metabolic process 57 1431 1.11e-05
GO:BP GO:0090304 nucleic acid metabolic process 30 4047 2.65e-05
GO:BP GO:0045893 positive regulation of DNA-templated transcription 53 1304 2.72e-05
GO:BP GO:1903508 positive regulation of nucleic acid-templated transcription 53 1304 2.72e-05
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 53 1311 3.03e-05
GO:BP GO:0031324 negative regulation of cellular metabolic process 63 1780 3.25e-05
GO:BP GO:0019222 regulation of metabolic process 137 5039 4.19e-05
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 59 1600 6.34e-05
GO:BP GO:0045944 positive regulation of transcription by RNA polymerase II 42 925 1.44e-04
GO:BP GO:0006139 nucleobase-containing compound metabolic process 30 4503 1.85e-04
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 63 1866 3.09e-04
GO:BP GO:0016070 RNA metabolic process 28 3593 3.16e-04
GO:BP GO:0046483 heterocycle metabolic process 30 4616 3.16e-04
GO:BP GO:0019827 stem cell population maintenance 13 150 3.35e-04
GO:BP GO:0006725 cellular aromatic compound metabolic process 30 4646 3.67e-04
GO:BP GO:0098727 maintenance of cell number 13 152 4.11e-04
GO:BP GO:0010557 positive regulation of macromolecule biosynthetic process 54 1499 4.30e-04
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 46 2425 4.88e-04
GO:BP GO:1901360 organic cyclic compound metabolic process 30 4790 7.44e-04
GO:BP GO:0034641 cellular nitrogen compound metabolic process 30 4991 1.27e-03
GO:BP GO:0031328 positive regulation of cellular biosynthetic process 54 1571 1.87e-03
GO:BP GO:0009891 positive regulation of biosynthetic process 49 1598 3.03e-03
GO:BP GO:1902459 positive regulation of stem cell population maintenance 6 44 3.03e-03
GO:BP GO:2000036 regulation of stem cell population maintenance 6 62 3.03e-03
GO:BP GO:0031325 positive regulation of cellular metabolic process 43 2373 3.67e-03
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 46 2648 4.12e-03
GO:BP GO:0035019 somatic stem cell population maintenance 7 50 4.62e-03
GO:BP GO:1900034 regulation of cellular response to heat 4 16 5.03e-03
GO:BP GO:1904290 negative regulation of mitotic DNA damage checkpoint 1 1 7.52e-03
GO:BP GO:0015074 DNA integration 3 11 1.01e-02
GO:BP GO:0006297 nucleotide-excision repair, DNA gap filling 2 5 1.40e-02
GO:BP GO:0045444 fat cell differentiation 11 187 1.42e-02
GO:BP GO:0006473 protein acetylation 12 208 1.64e-02
GO:BP GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 9 126 1.70e-02
GO:BP GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 9 127 1.96e-02
GO:BP GO:1904289 regulation of mitotic DNA damage checkpoint 1 3 2.04e-02
GO:BP GO:1903676 positive regulation of cap-dependent translational initiation 1 1 2.31e-02
GO:BP GO:1903674 regulation of cap-dependent translational initiation 1 1 2.31e-02
GO:BP GO:0010944 negative regulation of transcription by competitive promoter binding 2 8 2.39e-02
GO:BP GO:0045643 regulation of eosinophil differentiation 1 1 2.51e-02
GO:BP GO:0045659 negative regulation of neutrophil differentiation 1 2 2.51e-02
GO:BP GO:0045645 positive regulation of eosinophil differentiation 1 1 2.51e-02
GO:BP GO:0002763 positive regulation of myeloid leukocyte differentiation 2 34 2.66e-02
GO:BP GO:0009893 positive regulation of metabolic process 46 2884 2.70e-02
GO:BP GO:0045658 regulation of neutrophil differentiation 1 2 3.57e-02
GO:BP GO:2000002 negative regulation of DNA damage checkpoint 1 5 3.57e-02
GO:BP GO:0003151 outflow tract morphogenesis 6 66 3.57e-02
GO:BP GO:0006968 cellular defense response 2 15 3.66e-02
GO:BP GO:0048538 thymus development 5 35 4.01e-02
GO:BP GO:0006325 chromatin organization 21 536 4.02e-02
GO:BP GO:0060411 cardiac septum morphogenesis 4 67 4.33e-02
GO:BP GO:0043543 protein acylation 8 246 4.52e-02
GO:BP GO:0030853 negative regulation of granulocyte differentiation 2 6 4.61e-02
GO:BP GO:1900036 positive regulation of cellular response to heat 1 1 4.62e-02
GO:BP GO:0003281 ventricular septum development 4 69 4.69e-02
GO:BP GO:0018394 peptidyl-lysine acetylation 10 180 4.69e-02
GO:BP GO:0055025 positive regulation of cardiac muscle tissue development 1 2 4.69e-02
GO:BP GO:0018076 N-terminal peptidyl-lysine acetylation 2 4 4.69e-02
GO:BP GO:0060324 face development 5 44 4.69e-02
GO:BP GO:0043923 positive regulation by host of viral transcription 3 17 4.69e-02
GO:BP GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 12 229 4.87e-02
GO:BP GO:0030222 eosinophil differentiation 1 2 4.94e-02
GO:BP GO:1901977 negative regulation of cell cycle checkpoint 1 8 4.94e-02
GO:BP GO:0090721 primary adaptive immune response involving T cells and B cells 1 1 4.98e-02
GO:BP GO:0090720 primary adaptive immune response 1 1 4.98e-02
GO:BP GO:1903677 regulation of cap-independent translational initiation 1 3 4.98e-02
GO:BP GO:1903679 positive regulation of cap-independent translational initiation 1 3 4.98e-02
KEGG KEGG:05168 Herpes simplex virus 1 infection 31 415 7.79e-09
source term_id term_name intersection_size term_size p_value
GO:BP GO:0007059 chromosome segregation 103 378 4.04e-11
GO:BP GO:0000278 mitotic cell cycle 210 833 5.51e-11
GO:BP GO:0000819 sister chromatid segregation 70 234 1.28e-10
GO:BP GO:0000070 mitotic sister chromatid segregation 61 193 1.53e-10
GO:BP GO:1903047 mitotic cell cycle process 178 700 5.35e-10
GO:BP GO:0140014 mitotic nuclear division 44 264 6.38e-10
GO:BP GO:0098813 nuclear chromosome segregation 80 287 1.10e-08
GO:BP GO:0010564 regulation of cell cycle process 111 620 1.10e-08
GO:BP GO:0051276 chromosome organization 122 543 3.28e-08
GO:BP GO:0007093 mitotic cell cycle checkpoint signaling 45 136 5.05e-08
GO:BP GO:0051726 regulation of cell cycle 151 950 5.99e-08
GO:BP GO:0045930 negative regulation of mitotic cell cycle 68 208 7.02e-08
GO:BP GO:0051301 cell division 129 567 8.59e-08
GO:BP GO:0000075 cell cycle checkpoint signaling 53 180 1.40e-07
GO:BP GO:0000280 nuclear division 115 354 3.17e-07
GO:BP GO:0022402 cell cycle process 165 1075 3.96e-07
GO:BP GO:0007049 cell cycle 217 1522 1.11e-06
GO:BP GO:0008608 attachment of spindle microtubules to kinetochore 20 42 1.82e-06
GO:BP GO:0007051 spindle organization 29 186 4.05e-06
GO:BP GO:0051983 regulation of chromosome segregation 37 118 4.34e-06
GO:BP GO:0007052 mitotic spindle organization 28 128 4.34e-06
GO:BP GO:0048285 organelle fission 119 397 5.95e-06
GO:BP GO:1905818 regulation of chromosome separation 26 69 1.07e-05
GO:BP GO:0045786 negative regulation of cell cycle 96 334 1.07e-05
GO:BP GO:1902850 microtubule cytoskeleton organization involved in mitosis 35 156 1.41e-05
GO:BP GO:0030071 regulation of mitotic metaphase/anaphase transition 29 88 1.76e-05
GO:BP GO:0007346 regulation of mitotic cell cycle 110 438 1.78e-05
GO:BP GO:2001251 negative regulation of chromosome organization 30 90 2.02e-05
GO:BP GO:0051225 spindle assembly 36 118 2.07e-05
GO:BP GO:0010948 negative regulation of cell cycle process 65 270 3.12e-05
GO:BP GO:0007091 metaphase/anaphase transition of mitotic cell cycle 29 91 3.12e-05
GO:BP GO:1901988 negative regulation of cell cycle phase transition 58 232 3.12e-05
GO:BP GO:1902099 regulation of metaphase/anaphase transition of cell cycle 29 89 3.12e-05
GO:BP GO:0007080 mitotic metaphase plate congression 14 55 3.28e-05
GO:BP GO:0071174 mitotic spindle checkpoint signaling 16 44 3.88e-05
GO:BP GO:0007094 mitotic spindle assembly checkpoint signaling 16 44 3.88e-05
GO:BP GO:0071173 spindle assembly checkpoint signaling 16 44 3.88e-05
GO:BP GO:0051304 chromosome separation 26 74 4.03e-05
GO:BP GO:0045839 negative regulation of mitotic nuclear division 21 54 4.43e-05
GO:BP GO:0006974 cellular response to DNA damage stimulus 150 789 4.43e-05
GO:BP GO:0031577 spindle checkpoint signaling 16 45 4.90e-05
GO:BP GO:0044784 metaphase/anaphase transition of cell cycle 29 92 5.09e-05
GO:BP GO:0045841 negative regulation of mitotic metaphase/anaphase transition 19 46 6.08e-05
GO:BP GO:0010965 regulation of mitotic sister chromatid separation 14 58 6.08e-05
GO:BP GO:0044774 mitotic DNA integrity checkpoint signaling 28 82 6.08e-05
GO:BP GO:0031570 DNA integrity checkpoint signaling 37 126 6.82e-05
GO:BP GO:0051988 regulation of attachment of spindle microtubules to kinetochore 11 18 7.36e-05
GO:BP GO:0033045 regulation of sister chromatid segregation 30 99 7.77e-05
GO:BP GO:0033047 regulation of mitotic sister chromatid segregation 17 52 7.77e-05
GO:BP GO:0051310 metaphase plate congression 15 69 7.77e-05
GO:BP GO:0051783 regulation of nuclear division 30 115 8.44e-05
GO:BP GO:2000816 negative regulation of mitotic sister chromatid separation 16 47 9.08e-05
GO:BP GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 16 47 9.08e-05
GO:BP GO:0033046 negative regulation of sister chromatid segregation 16 47 9.08e-05
GO:BP GO:0006281 DNA repair 107 535 9.08e-05
GO:BP GO:0033048 negative regulation of mitotic sister chromatid segregation 16 47 9.08e-05
GO:BP GO:0051306 mitotic sister chromatid separation 14 61 9.08e-05
GO:BP GO:0006260 DNA replication 83 258 9.68e-05
GO:BP GO:0006261 DNA-templated DNA replication 54 149 1.06e-04
GO:BP GO:0007088 regulation of mitotic nuclear division 27 100 1.06e-04
GO:BP GO:0000226 microtubule cytoskeleton organization 85 552 1.10e-04
GO:BP GO:0033044 regulation of chromosome organization 53 233 1.24e-04
GO:BP GO:1905819 negative regulation of chromosome separation 16 48 1.45e-04
GO:BP GO:0051985 negative regulation of chromosome segregation 16 48 1.45e-04
GO:BP GO:0090068 positive regulation of cell cycle process 61 206 1.53e-04
GO:BP GO:1901987 regulation of cell cycle phase transition 64 388 1.60e-04
GO:BP GO:0044772 mitotic cell cycle phase transition 97 413 1.67e-04
GO:BP GO:0051231 spindle elongation 9 12 1.84e-04
GO:BP GO:1901991 negative regulation of mitotic cell cycle phase transition 48 163 1.84e-04
GO:BP GO:0044773 mitotic DNA damage checkpoint signaling 26 78 1.84e-04
GO:BP GO:0051256 mitotic spindle midzone assembly 8 9 1.85e-04
GO:BP GO:1901990 regulation of mitotic cell cycle phase transition 76 305 2.00e-04
GO:BP GO:0050000 chromosome localization 16 82 2.21e-04
GO:BP GO:0000077 DNA damage checkpoint signaling 34 118 2.21e-04
GO:BP GO:0051784 negative regulation of nuclear division 21 57 2.21e-04
GO:BP GO:0044770 cell cycle phase transition 114 499 2.21e-04
GO:BP GO:0051984 positive regulation of chromosome segregation 16 25 2.55e-04
GO:BP GO:0090307 mitotic spindle assembly 17 69 2.87e-04
GO:BP GO:0051255 spindle midzone assembly 9 12 3.19e-04
GO:BP GO:0051303 establishment of chromosome localization 15 75 3.67e-04
GO:BP GO:0000022 mitotic spindle elongation 8 10 4.44e-04
GO:BP GO:0032465 regulation of cytokinesis 25 79 5.27e-04
GO:BP GO:0042770 signal transduction in response to DNA damage 34 173 5.54e-04
GO:BP GO:0060236 regulation of mitotic spindle organization 8 42 5.98e-04
GO:BP GO:0000086 G2/M transition of mitotic cell cycle 37 134 8.65e-04
GO:BP GO:0006275 regulation of DNA replication 45 124 9.91e-04
GO:BP GO:0006541 glutamine metabolic process 4 23 1.07e-03
GO:BP GO:0010639 negative regulation of organelle organization 64 318 1.08e-03
GO:BP GO:0090224 regulation of spindle organization 8 45 1.10e-03
GO:BP GO:0010389 regulation of G2/M transition of mitotic cell cycle 30 92 1.19e-03
GO:BP GO:0033043 regulation of organelle organization 172 1023 1.21e-03
GO:BP GO:0051383 kinetochore organization 9 23 1.33e-03
GO:BP GO:0051315 attachment of mitotic spindle microtubules to kinetochore 10 21 1.36e-03
GO:BP GO:0044839 cell cycle G2/M phase transition 39 148 1.49e-03
GO:BP GO:0006270 DNA replication initiation 18 35 1.61e-03
GO:BP GO:0090329 regulation of DNA-templated DNA replication 24 54 1.80e-03
GO:BP GO:0000731 DNA synthesis involved in DNA repair 15 36 2.11e-03
GO:BP GO:0051302 regulation of cell division 24 144 2.15e-03
GO:BP GO:0010212 response to ionizing radiation 35 130 2.93e-03
GO:BP GO:0006301 postreplication repair 11 34 3.17e-03
GO:BP GO:0006271 DNA strand elongation involved in DNA replication 13 15 4.18e-03
GO:BP GO:0071478 cellular response to radiation 41 155 4.57e-03
GO:BP GO:1901976 regulation of cell cycle checkpoint 13 45 4.57e-03
GO:BP GO:1903490 positive regulation of mitotic cytokinesis 6 7 4.57e-03
GO:BP GO:1905820 positive regulation of chromosome separation 11 26 4.81e-03
GO:BP GO:0019985 translesion synthesis 9 24 4.87e-03
GO:BP GO:0000281 mitotic cytokinesis 17 81 5.93e-03
GO:BP GO:0009411 response to UV 34 137 5.93e-03
GO:BP GO:0044818 mitotic G2/M transition checkpoint 17 50 6.56e-03
GO:BP GO:0060623 regulation of chromosome condensation 6 9 7.13e-03
GO:BP GO:0007017 microtubule-based process 65 756 7.38e-03
GO:BP GO:1902412 regulation of mitotic cytokinesis 7 8 7.58e-03
GO:BP GO:0006167 AMP biosynthetic process 3 14 8.10e-03
GO:BP GO:0044314 protein K27-linked ubiquitination 8 8 8.43e-03
GO:BP GO:1902749 regulation of cell cycle G2/M phase transition 30 102 8.48e-03
GO:BP GO:0030510 regulation of BMP signaling pathway 4 84 8.48e-03
GO:BP GO:0045005 DNA-templated DNA replication maintenance of fidelity 17 50 8.48e-03
GO:BP GO:0007095 mitotic G2 DNA damage checkpoint signaling 13 35 8.85e-03
GO:BP GO:0006177 GMP biosynthetic process 3 14 9.58e-03
GO:BP GO:0104004 cellular response to environmental stimulus 62 264 9.75e-03
GO:BP GO:0071214 cellular response to abiotic stimulus 62 264 9.75e-03
GO:BP GO:0036166 phenotypic switching 5 7 9.90e-03
GO:BP GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 19 60 1.02e-02
GO:BP GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore 6 8 1.04e-02
GO:BP GO:1902423 regulation of attachment of mitotic spindle microtubules to kinetochore 6 8 1.04e-02
GO:BP GO:0034644 cellular response to UV 23 83 1.05e-02
GO:BP GO:0046060 dATP metabolic process 2 3 1.05e-02
GO:BP GO:0000910 cytokinesis 20 163 1.10e-02
GO:BP GO:0032508 DNA duplex unwinding 24 75 1.11e-02
GO:BP GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore 7 11 1.19e-02
GO:BP GO:0044786 cell cycle DNA replication 18 40 1.29e-02
GO:BP GO:0009314 response to radiation 59 349 1.43e-02
GO:BP GO:0045787 positive regulation of cell cycle 70 278 1.46e-02
GO:BP GO:1902750 negative regulation of cell cycle G2/M phase transition 19 62 1.49e-02
GO:BP GO:0046037 GMP metabolic process 4 24 1.59e-02
GO:BP GO:0046602 regulation of mitotic centrosome separation 6 8 1.64e-02
GO:BP GO:0140013 meiotic nuclear division 44 121 1.65e-02
GO:BP GO:0071897 DNA biosynthetic process 55 175 1.74e-02
GO:BP GO:0099625 ventricular cardiac muscle cell membrane repolarization 5 21 1.75e-02
GO:BP GO:1903046 meiotic cell cycle process 47 136 1.75e-02
GO:BP GO:0030174 regulation of DNA-templated DNA replication initiation 9 14 1.80e-02
GO:BP GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization 3 7 1.91e-02
GO:BP GO:0007098 centrosome cycle 23 126 1.99e-02
GO:BP GO:0006259 DNA metabolic process 154 890 1.99e-02
GO:BP GO:0007079 mitotic chromosome movement towards spindle pole 3 4 2.08e-02
GO:BP GO:0071480 cellular response to gamma radiation 17 29 2.23e-02
GO:BP GO:0007076 mitotic chromosome condensation 8 19 2.25e-02
GO:BP GO:0061642 chemoattraction of axon 2 2 2.26e-02
GO:BP GO:0061640 cytoskeleton-dependent cytokinesis 20 103 2.28e-02
GO:BP GO:0086067 AV node cell to bundle of His cell communication 7 11 2.35e-02
GO:BP GO:0000302 response to reactive oxygen species 24 160 2.35e-02
GO:BP GO:0034502 protein localization to chromosome 14 110 2.40e-02
GO:BP GO:0042148 strand invasion 4 5 2.58e-02
GO:BP GO:0009168 purine ribonucleoside monophosphate biosynthetic process 3 22 2.78e-02
GO:BP GO:0006268 DNA unwinding involved in DNA replication 11 22 2.79e-02
GO:BP GO:0032263 GMP salvage 2 4 2.82e-02
GO:BP GO:0044209 AMP salvage 2 5 2.82e-02
GO:BP GO:0031023 microtubule organizing center organization 24 136 2.84e-02
GO:BP GO:0032392 DNA geometric change 28 81 2.85e-02
GO:BP GO:0062197 cellular response to chemical stress 43 290 2.85e-02
GO:BP GO:0014029 neural crest formation 7 13 2.85e-02
GO:BP GO:0030509 BMP signaling pathway 4 123 2.99e-02
GO:BP GO:0009064 glutamine family amino acid metabolic process 3 61 2.99e-02
GO:BP GO:0002227 innate immune response in mucosa 5 8 3.03e-02
GO:BP GO:0086012 membrane depolarization during cardiac muscle cell action potential 9 21 3.04e-02
GO:BP GO:1902969 mitotic DNA replication 11 14 3.04e-02
GO:BP GO:1900264 positive regulation of DNA-directed DNA polymerase activity 11 13 3.13e-02
GO:BP GO:0051299 centrosome separation 13 14 3.13e-02
GO:BP GO:0007062 sister chromatid cohesion 29 51 3.13e-02
GO:BP GO:1900262 regulation of DNA-directed DNA polymerase activity 11 13 3.13e-02
GO:BP GO:0030330 DNA damage response, signal transduction by p53 class mediator 10 68 3.13e-02
GO:BP GO:0046033 AMP metabolic process 3 22 3.17e-02
GO:BP GO:0009127 purine nucleoside monophosphate biosynthetic process 3 24 3.17e-02
GO:BP GO:0034599 cellular response to oxidative stress 37 239 3.17e-02
GO:BP GO:0099558 maintenance of synapse structure 8 20 3.17e-02
GO:BP GO:1905821 positive regulation of chromosome condensation 4 5 3.19e-02
GO:BP GO:0086027 AV node cell to bundle of His cell signaling 3 9 3.19e-02
GO:BP GO:0086016 AV node cell action potential 3 9 3.19e-02
GO:BP GO:1905832 positive regulation of spindle assembly 5 7 3.19e-02
GO:BP GO:0042542 response to hydrogen peroxide 17 103 3.28e-02
GO:BP GO:0140694 non-membrane-bounded organelle assembly 63 355 3.28e-02
GO:BP GO:0060444 branching involved in mammary gland duct morphogenesis 12 20 3.28e-02
GO:BP GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint 6 12 3.28e-02
GO:BP GO:0090232 positive regulation of spindle checkpoint 6 12 3.28e-02
GO:BP GO:0071773 cellular response to BMP stimulus 4 131 3.37e-02
GO:BP GO:0071772 response to BMP 4 131 3.37e-02
GO:BP GO:0090235 regulation of metaphase plate congression 7 13 3.40e-02
GO:BP GO:0006290 pyrimidine dimer repair 1 7 3.41e-02
GO:BP GO:0034501 protein localization to kinetochore 11 18 3.49e-02
GO:BP GO:1903083 protein localization to condensed chromosome 11 18 3.49e-02
GO:BP GO:0006285 base-excision repair, AP site formation 10 12 3.54e-02
GO:BP GO:0010032 meiotic chromosome condensation 4 6 3.54e-02
GO:BP GO:0046601 positive regulation of centriole replication 8 9 3.54e-02
GO:BP GO:0006979 response to oxidative stress 41 349 3.54e-02
GO:BP GO:0006284 base-excision repair 27 44 3.63e-02
GO:BP GO:1901751 leukotriene A4 metabolic process 2 2 3.78e-02
GO:BP GO:0009084 glutamine family amino acid biosynthetic process 2 17 3.87e-02
GO:BP GO:0071103 DNA conformation change 22 88 3.87e-02
GO:BP GO:0046112 nucleobase biosynthetic process 9 18 3.91e-02
GO:BP GO:0060509 type I pneumocyte differentiation 8 8 3.99e-02
GO:BP GO:0033260 nuclear DNA replication 15 35 4.05e-02
GO:BP GO:1902115 regulation of organelle assembly 18 186 4.20e-02
GO:BP GO:0046053 dAMP metabolic process 2 5 4.50e-02
GO:BP GO:0009215 purine deoxyribonucleoside triphosphate metabolic process 2 7 4.50e-02
GO:BP GO:1990227 paranodal junction maintenance 1 2 4.50e-02
GO:BP GO:0051321 meiotic cell cycle 57 188 4.50e-02
GO:BP GO:0010332 response to gamma radiation 26 50 4.51e-02
GO:BP GO:0045132 meiotic chromosome segregation 23 69 4.76e-02
GO:BP GO:0051298 centrosome duplication 4 68 4.83e-02
GO:BP GO:1902117 positive regulation of organelle assembly 10 75 5.00e-02
KEGG KEGG:04115 p53 signaling pathway 10 65 1.37e-05
KEGG KEGG:04110 Cell cycle 13 121 1.00e-04
KEGG KEGG:03410 Base excision repair 26 33 2.70e-04
KEGG KEGG:03030 DNA replication 13 35 4.66e-04
KEGG KEGG:03430 Mismatch repair 16 22 3.99e-03
KEGG KEGG:03440 Homologous recombination 11 39 7.47e-03
KEGG KEGG:05322 Systemic lupus erythematosus 12 61 1.09e-02
KEGG KEGG:05034 Alcoholism 7 122 1.12e-02
KEGG KEGG:04217 Necroptosis 7 106 1.19e-02
KEGG KEGG:04613 Neutrophil extracellular trap formation 2 110 1.96e-02
KEGG KEGG:01524 Platinum drug resistance 17 65 4.11e-02
KEGG KEGG:04964 Proximal tubule bicarbonate reclamation 2 20 4.86e-02

Epirubicin specific genes at 24 hours n= 489 genes are starting to show some apoptosis enrichment for myeloid cells.

Mitoxantrone specific 24 hour genes show an enrichment for DNA DSB repair. (n=188)

Mitoxantrone DEGs (adj. p value < 0.05)

3 hour = 58 24 hour = 1327

source term_id term_name intersection_size term_size p_value
GO:BP GO:0051252 regulation of RNA metabolic process 33 2849 6.85e-08
GO:BP GO:2001141 regulation of RNA biosynthetic process 31 2598 1.10e-07
GO:BP GO:1903506 regulation of nucleic acid-templated transcription 31 2581 1.10e-07
GO:BP GO:0006355 regulation of DNA-templated transcription 31 2579 1.10e-07
GO:BP GO:0019219 regulation of nucleobase-containing compound metabolic process 33 3105 1.30e-07
GO:BP GO:0006351 DNA-templated transcription 31 2683 1.30e-07
GO:BP GO:0097659 nucleic acid-templated transcription 31 2684 1.30e-07
GO:BP GO:0032774 RNA biosynthetic process 31 2714 1.50e-07
GO:BP GO:0010556 regulation of macromolecule biosynthetic process 32 3015 2.26e-07
GO:BP GO:0031326 regulation of cellular biosynthetic process 32 3123 6.03e-07
GO:BP GO:0009889 regulation of biosynthetic process 32 3174 8.48e-07
GO:BP GO:0006357 regulation of transcription by RNA polymerase II 28 1915 1.62e-06
GO:BP GO:0034654 nucleobase-containing compound biosynthetic process 31 3083 2.09e-06
GO:BP GO:0051171 regulation of nitrogen compound metabolic process 36 4330 2.81e-06
GO:BP GO:0019438 aromatic compound biosynthetic process 31 3149 2.81e-06
GO:BP GO:0018130 heterocycle biosynthetic process 31 3148 2.81e-06
GO:BP GO:0006366 transcription by RNA polymerase II 28 1991 2.81e-06
GO:BP GO:0010468 regulation of gene expression 35 3583 4.67e-06
GO:BP GO:0080090 regulation of primary metabolic process 36 4440 5.49e-06
GO:BP GO:1901362 organic cyclic compound biosynthetic process 31 3253 5.86e-06
GO:BP GO:0031323 regulation of cellular metabolic process 35 4305 9.38e-06
GO:BP GO:0009059 macromolecule biosynthetic process 32 3730 1.87e-05
GO:BP GO:0000122 negative regulation of transcription by RNA polymerase II 10 735 2.39e-05
GO:BP GO:0044271 cellular nitrogen compound biosynthetic process 32 3758 2.47e-05
GO:BP GO:0051890 regulation of cardioblast differentiation 3 7 8.49e-05
GO:BP GO:0051253 negative regulation of RNA metabolic process 11 1115 8.90e-05
GO:BP GO:0031324 negative regulation of cellular metabolic process 13 1780 1.13e-04
GO:BP GO:0010558 negative regulation of macromolecule biosynthetic process 11 1206 1.61e-04
GO:BP GO:0045934 negative regulation of nucleobase-containing compound metabolic process 11 1215 1.86e-04
GO:BP GO:0031327 negative regulation of cellular biosynthetic process 11 1249 2.18e-04
GO:BP GO:0051172 negative regulation of nitrogen compound metabolic process 13 1866 2.18e-04
GO:BP GO:0009890 negative regulation of biosynthetic process 11 1273 2.49e-04
GO:BP GO:1903507 negative regulation of nucleic acid-templated transcription 10 1011 2.86e-04
GO:BP GO:0045892 negative regulation of DNA-templated transcription 10 1009 2.86e-04
GO:BP GO:0060255 regulation of macromolecule metabolic process 36 4640 2.97e-04
GO:BP GO:1902679 negative regulation of RNA biosynthetic process 10 1020 2.97e-04
GO:BP GO:0060411 cardiac septum morphogenesis 5 67 4.18e-04
GO:BP GO:0051254 positive regulation of RNA metabolic process 20 1431 6.36e-04
GO:BP GO:0060419 heart growth 5 72 9.71e-04
GO:BP GO:0035051 cardiocyte differentiation 6 129 9.88e-04
GO:BP GO:0036490 regulation of translation in response to endoplasmic reticulum stress 2 11 9.89e-04
GO:BP GO:0044249 cellular biosynthetic process 32 4465 1.04e-03
GO:BP GO:0010002 cardioblast differentiation 3 17 1.14e-03
GO:BP GO:0110021 cardiac muscle myoblast proliferation 2 3 1.21e-03
GO:BP GO:0110022 regulation of cardiac muscle myoblast proliferation 2 3 1.21e-03
GO:BP GO:0110024 positive regulation of cardiac muscle myoblast proliferation 2 3 1.21e-03
GO:BP GO:0051891 positive regulation of cardioblast differentiation 2 6 1.24e-03
GO:BP GO:1901576 organic substance biosynthetic process 32 4537 1.35e-03
GO:BP GO:0035265 organ growth 6 129 1.63e-03
GO:BP GO:0016070 RNA metabolic process 35 3593 1.69e-03
GO:BP GO:0003148 outflow tract septum morphogenesis 3 23 1.75e-03
GO:BP GO:0019222 regulation of metabolic process 36 5039 1.75e-03
GO:BP GO:0009058 biosynthetic process 32 4595 1.75e-03
GO:BP GO:0003162 atrioventricular node development 2 8 1.98e-03
GO:BP GO:1905207 regulation of cardiocyte differentiation 3 24 1.98e-03
GO:BP GO:1903508 positive regulation of nucleic acid-templated transcription 18 1304 1.98e-03
GO:BP GO:0045893 positive regulation of DNA-templated transcription 18 1304 1.98e-03
GO:BP GO:0045935 positive regulation of nucleobase-containing compound metabolic process 20 1600 2.02e-03
GO:BP GO:1902680 positive regulation of RNA biosynthetic process 18 1311 2.02e-03
GO:BP GO:0003279 cardiac septum development 5 101 2.03e-03
GO:BP GO:0055017 cardiac muscle tissue growth 4 65 2.09e-03
GO:BP GO:1900036 positive regulation of cellular response to heat 1 1 2.22e-03
GO:BP GO:0055007 cardiac muscle cell differentiation 5 102 2.22e-03
GO:BP GO:0090304 nucleic acid metabolic process 36 4047 2.64e-03
GO:BP GO:0007507 heart development 10 502 2.74e-03
GO:BP GO:0060420 regulation of heart growth 4 50 2.82e-03
GO:BP GO:0043555 regulation of translation in response to stress 2 23 3.02e-03
GO:BP GO:0003206 cardiac chamber morphogenesis 5 109 3.60e-03
GO:BP GO:0003181 atrioventricular valve morphogenesis 2 24 3.67e-03
GO:BP GO:0010605 negative regulation of macromolecule metabolic process 13 2146 4.30e-03
GO:BP GO:0036302 atrioventricular canal development 2 12 4.30e-03
GO:BP GO:0003171 atrioventricular valve development 2 26 4.46e-03
GO:BP GO:0003281 ventricular septum development 4 69 5.14e-03
GO:BP GO:1905209 positive regulation of cardiocyte differentiation 2 13 5.47e-03
GO:BP GO:0003180 aortic valve morphogenesis 2 27 6.04e-03
GO:BP GO:0048738 cardiac muscle tissue development 6 198 6.25e-03
GO:BP GO:0045944 positive regulation of transcription by RNA polymerase II 14 925 6.42e-03
GO:BP GO:0060421 positive regulation of heart growth 3 27 6.59e-03
GO:BP GO:0045596 negative regulation of cell differentiation 10 478 6.68e-03
GO:BP GO:0072164 mesonephric tubule development 2 76 7.17e-03
GO:BP GO:0001657 ureteric bud development 2 75 7.17e-03
GO:BP GO:0003176 aortic valve development 2 31 7.17e-03
GO:BP GO:0072163 mesonephric epithelium development 2 76 7.17e-03
GO:BP GO:0010557 positive regulation of macromolecule biosynthetic process 18 1499 7.17e-03
GO:BP GO:0060976 coronary vasculature development 3 44 7.17e-03
GO:BP GO:0009892 negative regulation of metabolic process 13 2306 7.17e-03
GO:BP GO:0031325 positive regulation of cellular metabolic process 24 2373 7.45e-03
GO:BP GO:0001823 mesonephros development 2 77 7.57e-03
GO:BP GO:0014706 striated muscle tissue development 6 210 7.73e-03
GO:BP GO:1905314 semi-lunar valve development 2 35 8.29e-03
GO:BP GO:0046620 regulation of organ growth 4 70 8.46e-03
GO:BP GO:1902010 negative regulation of translation in response to endoplasmic reticulum stress 1 1 9.10e-03
GO:BP GO:0030510 regulation of BMP signaling pathway 3 84 9.47e-03
GO:BP GO:0003007 heart morphogenesis 6 212 1.01e-02
GO:BP GO:0055021 regulation of cardiac muscle tissue growth 3 45 1.04e-02
GO:BP GO:0003205 cardiac chamber development 5 149 1.04e-02
GO:BP GO:2000738 positive regulation of stem cell differentiation 2 20 1.08e-02
GO:BP GO:0060575 intestinal epithelial cell differentiation 2 17 1.08e-02
GO:BP GO:0009887 animal organ morphogenesis 11 739 1.10e-02
GO:BP GO:0031328 positive regulation of cellular biosynthetic process 18 1571 1.11e-02
GO:BP GO:0007352 zygotic specification of dorsal/ventral axis 1 2 1.11e-02
GO:BP GO:0009893 positive regulation of metabolic process 27 2884 1.16e-02
GO:BP GO:2000288 positive regulation of myoblast proliferation 2 9 1.16e-02
GO:BP GO:1903674 regulation of cap-dependent translational initiation 1 1 1.17e-02
GO:BP GO:0002065 columnar/cuboidal epithelial cell differentiation 3 79 1.17e-02
GO:BP GO:1903676 positive regulation of cap-dependent translational initiation 1 1 1.17e-02
GO:BP GO:0046622 positive regulation of organ growth 3 33 1.17e-02
GO:BP GO:0006139 nucleobase-containing compound metabolic process 36 4503 1.18e-02
GO:BP GO:0072073 kidney epithelium development 2 112 1.22e-02
GO:BP GO:0003179 heart valve morphogenesis 2 50 1.22e-02
GO:BP GO:0009891 positive regulation of biosynthetic process 18 1598 1.28e-02
GO:BP GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 2 10 1.31e-02
GO:BP GO:0090720 primary adaptive immune response 1 1 1.33e-02
GO:BP GO:0090721 primary adaptive immune response involving T cells and B cells 1 1 1.33e-02
GO:BP GO:0034504 protein localization to nucleus 6 274 1.33e-02
GO:BP GO:0048565 digestive tract development 3 91 1.51e-02
GO:BP GO:0046483 heterocycle metabolic process 14 4616 1.60e-02
GO:BP GO:0003170 heart valve development 2 57 1.60e-02
GO:BP GO:0010604 positive regulation of macromolecule metabolic process 25 2648 1.66e-02
GO:BP GO:0060537 muscle tissue development 7 340 1.72e-02
GO:BP GO:0006725 cellular aromatic compound metabolic process 14 4646 1.72e-02
GO:BP GO:2000291 regulation of myoblast proliferation 2 11 1.77e-02
GO:BP GO:0055123 digestive system development 3 99 1.83e-02
GO:BP GO:0051173 positive regulation of nitrogen compound metabolic process 23 2425 1.87e-02
GO:BP GO:0051170 import into nucleus 4 151 1.89e-02
GO:BP GO:1900034 regulation of cellular response to heat 1 16 1.89e-02
GO:BP GO:0003215 cardiac right ventricle morphogenesis 2 17 1.97e-02
GO:BP GO:0010665 regulation of cardiac muscle cell apoptotic process 2 34 1.97e-02
GO:BP GO:0003151 outflow tract morphogenesis 3 66 2.03e-02
GO:BP GO:0003161 cardiac conduction system development 2 34 2.04e-02
GO:BP GO:0030513 positive regulation of BMP signaling pathway 2 34 2.08e-02
GO:BP GO:2000736 regulation of stem cell differentiation 3 74 2.08e-02
GO:BP GO:1904003 negative regulation of sebum secreting cell proliferation 1 1 2.08e-02
GO:BP GO:0010991 negative regulation of SMAD protein complex assembly 1 5 2.08e-02
GO:BP GO:0003290 atrial septum secundum morphogenesis 1 2 2.08e-02
GO:BP GO:0009725 response to hormone 4 629 2.10e-02
GO:BP GO:0035904 aorta development 3 49 2.10e-02
GO:BP GO:0010659 cardiac muscle cell apoptotic process 2 36 2.10e-02
GO:BP GO:0003231 cardiac ventricle development 4 114 2.10e-02
GO:BP GO:0030509 BMP signaling pathway 3 123 2.10e-02
GO:BP GO:0010662 regulation of striated muscle cell apoptotic process 2 37 2.10e-02
GO:BP GO:0055012 ventricular cardiac muscle cell differentiation 2 15 2.10e-02
GO:BP GO:1901360 organic cyclic compound metabolic process 14 4790 2.13e-02
GO:BP GO:0003300 cardiac muscle hypertrophy 3 72 2.19e-02
GO:BP GO:0021756 striatum development 2 17 2.24e-02
GO:BP GO:0006913 nucleocytoplasmic transport 4 294 2.25e-02
GO:BP GO:0010990 regulation of SMAD protein complex assembly 1 6 2.25e-02
GO:BP GO:0051169 nuclear transport 4 294 2.25e-02
GO:BP GO:0032055 negative regulation of translation in response to stress 1 4 2.25e-02
GO:BP GO:0010658 striated muscle cell apoptotic process 2 39 2.25e-02
GO:BP GO:0021542 dentate gyrus development 2 10 2.25e-02
GO:BP GO:0014897 striated muscle hypertrophy 3 73 2.30e-02
GO:BP GO:0071773 cellular response to BMP stimulus 3 131 2.31e-02
GO:BP GO:0071772 response to BMP 3 131 2.31e-02
GO:BP GO:0009880 embryonic pattern specification 3 50 2.35e-02
GO:BP GO:0060045 positive regulation of cardiac muscle cell proliferation 2 21 2.35e-02
GO:BP GO:1902882 regulation of response to oxidative stress 2 77 2.35e-02
GO:BP GO:1903677 regulation of cap-independent translational initiation 1 3 2.35e-02
GO:BP GO:0014896 muscle hypertrophy 3 74 2.35e-02
GO:BP GO:1903679 positive regulation of cap-independent translational initiation 1 3 2.35e-02
GO:BP GO:0009749 response to glucose 3 139 2.38e-02
GO:BP GO:0003301 physiological cardiac muscle hypertrophy 2 19 2.38e-02
GO:BP GO:0003298 physiological muscle hypertrophy 2 19 2.38e-02
GO:BP GO:0061049 cell growth involved in cardiac muscle cell development 2 19 2.38e-02
GO:BP GO:0034641 cellular nitrogen compound metabolic process 14 4991 2.43e-02
GO:BP GO:0009746 response to hexose 3 140 2.45e-02
GO:BP GO:1904504 positive regulation of lipophagy 1 5 2.45e-02
GO:BP GO:1904502 regulation of lipophagy 1 5 2.45e-02
GO:BP GO:0035054 embryonic heart tube anterior/posterior pattern specification 1 2 2.45e-02
GO:BP GO:0003285 septum secundum development 1 3 2.45e-02
GO:BP GO:0071495 cellular response to endogenous stimulus 5 1091 2.45e-02
GO:BP GO:0034284 response to monosaccharide 3 144 2.72e-02
GO:BP GO:2000257 regulation of protein activation cascade 1 1 2.87e-02
GO:BP GO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 1 4 2.87e-02
GO:BP GO:0002190 cap-independent translational initiation 1 4 2.87e-02
GO:BP GO:0003208 cardiac ventricle morphogenesis 3 62 2.90e-02
GO:BP GO:2000691 negative regulation of cardiac muscle cell myoblast differentiation 1 1 2.95e-02
GO:BP GO:2000690 regulation of cardiac muscle cell myoblast differentiation 1 1 2.95e-02
GO:BP GO:0051450 myoblast proliferation 2 17 2.95e-02
GO:BP GO:0003417 growth plate cartilage development 1 14 2.95e-02
GO:BP GO:0021544 subpallium development 2 18 2.97e-02
GO:BP GO:0055023 positive regulation of cardiac muscle tissue growth 2 24 2.97e-02
GO:BP GO:0007493 endodermal cell fate determination 1 1 2.97e-02
GO:BP GO:0032912 negative regulation of transforming growth factor beta2 production 1 2 2.97e-02
GO:BP GO:0001949 sebaceous gland cell differentiation 1 1 2.97e-02
GO:BP GO:1904002 regulation of sebum secreting cell proliferation 1 1 2.97e-02
GO:BP GO:0003183 mitral valve morphogenesis 1 10 2.97e-02
GO:BP GO:1901390 positive regulation of transforming growth factor beta activation 1 2 2.97e-02
GO:BP GO:0010467 gene expression 27 4572 2.97e-02
GO:BP GO:0051093 negative regulation of developmental process 10 659 2.98e-02
GO:BP GO:0072359 circulatory system development 10 879 3.01e-02
GO:BP GO:0045638 negative regulation of myeloid cell differentiation 3 68 3.01e-02
GO:BP GO:0001822 kidney development 2 244 3.03e-02
GO:BP GO:0061724 lipophagy 1 7 3.03e-02
GO:BP GO:0002067 glandular epithelial cell differentiation 3 49 3.12e-02
GO:BP GO:0055013 cardiac muscle cell development 3 70 3.12e-02
GO:BP GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress 1 5 3.12e-02
GO:BP GO:0003174 mitral valve development 1 11 3.12e-02
GO:BP GO:1904690 positive regulation of cytoplasmic translational initiation 1 5 3.12e-02
GO:BP GO:0072001 renal system development 2 250 3.12e-02
GO:BP GO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation 1 5 3.12e-02
GO:BP GO:0040007 growth 10 736 3.13e-02
GO:BP GO:2000647 negative regulation of stem cell proliferation 1 18 3.15e-02
GO:BP GO:0002089 lens morphogenesis in camera-type eye 2 18 3.15e-02
GO:BP GO:0003228 atrial cardiac muscle tissue development 2 18 3.15e-02
GO:BP GO:0009743 response to carbohydrate 3 163 3.19e-02
GO:BP GO:0009950 dorsal/ventral axis specification 1 10 3.19e-02
GO:BP GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 1 12 3.19e-02
GO:BP GO:0072331 signal transduction by p53 class mediator 3 160 3.19e-02
GO:BP GO:0007183 SMAD protein complex assembly 1 12 3.19e-02
GO:BP GO:1902893 regulation of miRNA transcription 2 51 3.21e-02
GO:BP GO:0061614 miRNA transcription 2 52 3.26e-02
GO:BP GO:0003289 atrial septum primum morphogenesis 1 5 3.26e-02
GO:BP GO:0032331 negative regulation of chondrocyte differentiation 1 18 3.26e-02
GO:BP GO:0003284 septum primum development 1 5 3.26e-02
GO:BP GO:0048589 developmental growth 8 516 3.39e-02
GO:BP GO:0002194 hepatocyte cell migration 1 1 3.39e-02
GO:BP GO:0043049 otic placode formation 1 1 3.39e-02
GO:BP GO:1903898 negative regulation of PERK-mediated unfolded protein response 1 6 3.39e-02
GO:BP GO:1904688 regulation of cytoplasmic translational initiation 1 6 3.39e-02
GO:BP GO:0061114 branching involved in pancreas morphogenesis 1 1 3.39e-02
GO:BP GO:2000979 positive regulation of forebrain neuron differentiation 1 1 3.39e-02
GO:BP GO:2000178 negative regulation of neural precursor cell proliferation 2 21 3.42e-02
GO:BP GO:0031333 negative regulation of protein-containing complex assembly 2 127 3.42e-02
GO:BP GO:0055006 cardiac cell development 3 76 3.42e-02
GO:BP GO:0003416 endochondral bone growth 1 22 3.42e-02
GO:BP GO:0034616 response to laminar fluid shear stress 1 14 3.42e-02
GO:BP GO:0035116 embryonic hindlimb morphogenesis 1 17 3.42e-02
GO:BP GO:1901031 regulation of response to reactive oxygen species 2 29 3.49e-02
GO:BP GO:0045637 regulation of myeloid cell differentiation 4 151 3.52e-02
GO:BP GO:1990654 sebum secreting cell proliferation 1 2 3.55e-02
GO:BP GO:0010660 regulation of muscle cell apoptotic process 2 57 3.55e-02
GO:BP GO:0031016 pancreas development 3 52 3.55e-02
GO:BP GO:0061061 muscle structure development 8 543 3.55e-02
GO:BP GO:0061026 cardiac muscle tissue regeneration 1 6 3.55e-02
GO:BP GO:0009719 response to endogenous stimulus 5 1258 3.55e-02
GO:BP GO:0098868 bone growth 1 23 3.63e-02
GO:BP GO:0061037 negative regulation of cartilage development 1 23 3.63e-02
GO:BP GO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress 1 7 3.65e-02
GO:BP GO:0034605 cellular response to heat 1 51 3.65e-02
GO:BP GO:0002191 cap-dependent translational initiation 1 7 3.65e-02
GO:BP GO:0048384 retinoic acid receptor signaling pathway 1 26 3.69e-02
GO:BP GO:0048566 embryonic digestive tract development 1 20 3.77e-02
GO:BP GO:0071233 cellular response to leucine 1 10 3.77e-02
GO:BP GO:0003184 pulmonary valve morphogenesis 1 17 3.79e-02
GO:BP GO:0043627 response to estrogen 2 51 3.79e-02
GO:BP GO:0060351 cartilage development involved in endochondral bone morphogenesis 1 25 3.79e-02
GO:BP GO:0051146 striated muscle cell differentiation 5 231 3.79e-02
GO:BP GO:0010657 muscle cell apoptotic process 2 60 3.79e-02
GO:BP GO:2000628 regulation of miRNA metabolic process 2 62 3.79e-02
GO:BP GO:0048048 embryonic eye morphogenesis 1 25 3.86e-02
GO:BP GO:0060290 transdifferentiation 1 2 3.86e-02
GO:BP GO:0035137 hindlimb morphogenesis 1 20 3.86e-02
GO:BP GO:0032056 positive regulation of translation in response to stress 1 8 3.90e-02
GO:BP GO:0036491 regulation of translation initiation in response to endoplasmic reticulum stress 1 8 3.90e-02
GO:BP GO:0007172 signal complex assembly 1 7 3.90e-02
GO:BP GO:0060043 regulation of cardiac muscle cell proliferation 2 32 3.90e-02
GO:BP GO:0048523 negative regulation of cellular process 15 3628 3.99e-02
GO:BP GO:0002068 glandular epithelial cell development 1 28 3.99e-02
GO:BP GO:0051892 negative regulation of cardioblast differentiation 1 1 4.07e-02
GO:BP GO:1990253 cellular response to leucine starvation 1 13 4.16e-02
GO:BP GO:0032665 regulation of interleukin-21 production 1 1 4.16e-02
GO:BP GO:0032625 interleukin-21 production 1 1 4.16e-02
GO:BP GO:0060486 club cell differentiation 1 3 4.16e-02
GO:BP GO:1900101 regulation of endoplasmic reticulum unfolded protein response 2 28 4.16e-02
GO:BP GO:0003209 cardiac atrium morphogenesis 2 26 4.16e-02
GO:BP GO:0003190 atrioventricular valve formation 1 8 4.16e-02
GO:BP GO:0032745 positive regulation of interleukin-21 production 1 1 4.16e-02
GO:BP GO:0006930 substrate-dependent cell migration, cell extension 1 8 4.19e-02
GO:BP GO:0080134 regulation of response to stress 7 1084 4.24e-02
GO:BP GO:0098751 bone cell development 2 26 4.30e-02
GO:BP GO:0003177 pulmonary valve development 1 20 4.30e-02
GO:BP GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress 1 10 4.56e-02
GO:BP GO:0043201 response to leucine 1 13 4.56e-02
GO:BP GO:0048617 embryonic foregut morphogenesis 1 6 4.56e-02
GO:BP GO:0042127 regulation of cell population proliferation 3 1141 4.68e-02
GO:BP GO:0007492 endoderm development 2 65 4.68e-02
GO:BP GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 2 29 4.80e-02
GO:BP GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 3 229 4.82e-02
GO:BP GO:0060840 artery development 3 82 4.82e-02
GO:BP GO:0010586 miRNA metabolic process 2 76 4.82e-02
GO:BP GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation 1 11 4.87e-02
GO:BP GO:1903897 regulation of PERK-mediated unfolded protein response 1 10 4.87e-02
GO:BP GO:0007440 foregut morphogenesis 1 7 4.89e-02
GO:BP GO:0002066 columnar/cuboidal epithelial cell development 1 38 4.89e-02
source term_id term_name intersection_size term_size p_value
GO:BP GO:1903047 mitotic cell cycle process 99 700 1.02e-61
GO:BP GO:0022402 cell cycle process 117 1075 4.84e-60
GO:BP GO:0000278 mitotic cell cycle 104 833 4.84e-60
GO:BP GO:0007049 cell cycle 133 1522 1.01e-58
GO:BP GO:0007059 chromosome segregation 75 378 9.96e-55
GO:BP GO:0098813 nuclear chromosome segregation 66 287 7.07e-51
GO:BP GO:0000280 nuclear division 72 354 9.04e-50
GO:BP GO:0140014 mitotic nuclear division 61 264 1.43e-48
GO:BP GO:0051276 chromosome organization 84 543 2.28e-48
GO:BP GO:0000819 sister chromatid segregation 57 234 1.93e-47
GO:BP GO:0000070 mitotic sister chromatid segregation 53 193 3.35e-47
GO:BP GO:0048285 organelle fission 72 397 6.12e-47
GO:BP GO:0051301 cell division 80 567 6.18e-47
GO:BP GO:0010564 regulation of cell cycle process 98 620 3.56e-45
GO:BP GO:0051726 regulation of cell cycle 87 950 7.08e-40
GO:BP GO:0044770 cell cycle phase transition 76 499 4.59e-34
GO:BP GO:1901987 regulation of cell cycle phase transition 68 388 3.42e-32
GO:BP GO:0000075 cell cycle checkpoint signaling 47 180 7.73e-32
GO:BP GO:0006261 DNA-templated DNA replication 56 149 2.62e-30
GO:BP GO:0007346 regulation of mitotic cell cycle 69 438 1.54e-29
GO:BP GO:0044772 mitotic cell cycle phase transition 66 413 2.50e-29
GO:BP GO:0007093 mitotic cell cycle checkpoint signaling 40 136 2.93e-29
GO:BP GO:1902850 microtubule cytoskeleton organization involved in mitosis 28 156 5.47e-29
GO:BP GO:0051983 regulation of chromosome segregation 26 118 5.56e-28
GO:BP GO:1901988 negative regulation of cell cycle phase transition 49 232 6.25e-28
GO:BP GO:0006260 DNA replication 70 258 7.28e-28
GO:BP GO:0010948 negative regulation of cell cycle process 52 270 1.34e-27
GO:BP GO:0007051 spindle organization 26 186 2.38e-27
GO:BP GO:1901990 regulation of mitotic cell cycle phase transition 55 305 6.02e-27
GO:BP GO:0090068 positive regulation of cell cycle process 39 206 1.69e-25
GO:BP GO:0007052 mitotic spindle organization 22 128 2.88e-25
GO:BP GO:0045930 negative regulation of mitotic cell cycle 44 208 3.93e-25
GO:BP GO:0045786 negative regulation of cell cycle 55 334 4.10e-25
GO:BP GO:0000226 microtubule cytoskeleton organization 49 552 5.25e-25
GO:BP GO:0007091 metaphase/anaphase transition of mitotic cell cycle 22 91 7.33e-25
GO:BP GO:1905818 regulation of chromosome separation 20 69 8.92e-25
GO:BP GO:0044784 metaphase/anaphase transition of cell cycle 22 92 1.48e-24
GO:BP GO:0051304 chromosome separation 20 74 4.79e-24
GO:BP GO:0033045 regulation of sister chromatid segregation 22 99 9.24e-24
GO:BP GO:0006974 cellular response to DNA damage stimulus 109 789 1.34e-23
GO:BP GO:0030071 regulation of mitotic metaphase/anaphase transition 21 88 1.44e-23
GO:BP GO:0006259 DNA metabolic process 85 890 1.69e-23
GO:BP GO:1902099 regulation of metaphase/anaphase transition of cell cycle 21 89 2.87e-23
GO:BP GO:0007088 regulation of mitotic nuclear division 29 100 4.13e-23
GO:BP GO:0010965 regulation of mitotic sister chromatid separation 18 58 5.60e-23
GO:BP GO:0051306 mitotic sister chromatid separation 18 61 1.45e-22
GO:BP GO:1901991 negative regulation of mitotic cell cycle phase transition 33 163 2.04e-22
GO:BP GO:0045787 positive regulation of cell cycle 41 278 3.32e-22
GO:BP GO:0033044 regulation of chromosome organization 27 233 1.07e-21
GO:BP GO:0051783 regulation of nuclear division 29 115 1.16e-21
GO:BP GO:0007094 mitotic spindle assembly checkpoint signaling 16 44 1.27e-21
GO:BP GO:0071173 spindle assembly checkpoint signaling 16 44 1.27e-21
GO:BP GO:0071174 mitotic spindle checkpoint signaling 16 44 1.27e-21
GO:BP GO:0031577 spindle checkpoint signaling 16 45 1.85e-21
GO:BP GO:0008608 attachment of spindle microtubules to kinetochore 19 42 2.30e-21
GO:BP GO:0045841 negative regulation of mitotic metaphase/anaphase transition 16 46 2.64e-21
GO:BP GO:0033048 negative regulation of mitotic sister chromatid segregation 16 47 5.22e-21
GO:BP GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 16 47 5.22e-21
GO:BP GO:0033046 negative regulation of sister chromatid segregation 16 47 5.22e-21
GO:BP GO:2000816 negative regulation of mitotic sister chromatid separation 16 47 5.22e-21
GO:BP GO:0007017 microtubule-based process 41 756 8.17e-21
GO:BP GO:2001251 negative regulation of chromosome organization 19 90 8.88e-21
GO:BP GO:0051985 negative regulation of chromosome segregation 16 48 1.00e-20
GO:BP GO:1905819 negative regulation of chromosome separation 16 48 1.00e-20
GO:BP GO:0033047 regulation of mitotic sister chromatid segregation 16 52 2.72e-20
GO:BP GO:0045839 negative regulation of mitotic nuclear division 16 54 3.71e-20
GO:BP GO:0006281 DNA repair 81 535 5.94e-20
GO:BP GO:0051784 negative regulation of nuclear division 16 57 2.92e-19
GO:BP GO:0051225 spindle assembly 18 118 4.37e-19
GO:BP GO:0051310 metaphase plate congression 20 69 8.69e-19
GO:BP GO:0031570 DNA integrity checkpoint signaling 29 126 5.46e-18
GO:BP GO:0050000 chromosome localization 21 82 5.75e-18
GO:BP GO:0006270 DNA replication initiation 22 35 6.50e-18
GO:BP GO:0051303 establishment of chromosome localization 20 75 2.32e-17
GO:BP GO:0006996 organelle organization 92 2971 4.16e-17
GO:BP GO:0051321 meiotic cell cycle 32 188 1.22e-16
GO:BP GO:0090307 mitotic spindle assembly 14 69 1.22e-16
GO:BP GO:0007080 mitotic metaphase plate congression 17 55 1.96e-16
GO:BP GO:0140694 non-membrane-bounded organelle assembly 23 355 2.02e-16
GO:BP GO:0090329 regulation of DNA-templated DNA replication 24 54 3.77e-16
GO:BP GO:0033043 regulation of organelle organization 41 1023 1.36e-15
GO:BP GO:0044839 cell cycle G2/M phase transition 35 148 1.55e-15
GO:BP GO:1903046 meiotic cell cycle process 27 136 2.70e-15
GO:BP GO:0140013 meiotic nuclear division 26 121 2.98e-15
GO:BP GO:0000086 G2/M transition of mitotic cell cycle 30 134 5.76e-15
GO:BP GO:0032392 DNA geometric change 29 81 7.20e-15
GO:BP GO:0032508 DNA duplex unwinding 28 75 8.18e-15
GO:BP GO:0000077 DNA damage checkpoint signaling 25 118 1.58e-14
GO:BP GO:0000281 mitotic cytokinesis 14 81 1.97e-14
GO:BP GO:0007010 cytoskeleton organization 42 1222 2.79e-14
GO:BP GO:0044774 mitotic DNA integrity checkpoint signaling 21 82 5.71e-14
GO:BP GO:0042770 signal transduction in response to DNA damage 29 173 6.10e-14
GO:BP GO:0071103 DNA conformation change 29 88 9.60e-14
GO:BP GO:0006275 regulation of DNA replication 34 124 1.54e-13
GO:BP GO:0000910 cytokinesis 21 163 1.94e-13
GO:BP GO:0033554 cellular response to stress 151 1677 2.01e-13
GO:BP GO:0044773 mitotic DNA damage checkpoint signaling 20 78 2.74e-13
GO:BP GO:0045132 meiotic chromosome segregation 19 69 3.04e-13
GO:BP GO:0051984 positive regulation of chromosome segregation 11 25 6.92e-13
GO:BP GO:0061640 cytoskeleton-dependent cytokinesis 14 103 9.97e-13
GO:BP GO:0051988 regulation of attachment of spindle microtubules to kinetochore 11 18 1.77e-12
GO:BP GO:1901976 regulation of cell cycle checkpoint 13 45 4.46e-12
GO:BP GO:0051231 spindle elongation 8 12 4.54e-12
GO:BP GO:0032465 regulation of cytokinesis 19 79 9.88e-12
GO:BP GO:0044786 cell cycle DNA replication 18 40 1.80e-11
GO:BP GO:0010389 regulation of G2/M transition of mitotic cell cycle 22 92 1.98e-11
GO:BP GO:0033260 nuclear DNA replication 17 35 2.15e-11
GO:BP GO:0010639 negative regulation of organelle organization 20 318 3.79e-11
GO:BP GO:0051315 attachment of mitotic spindle microtubules to kinetochore 8 21 4.14e-11
GO:BP GO:0051256 mitotic spindle midzone assembly 7 9 5.90e-11
GO:BP GO:1905820 positive regulation of chromosome separation 10 26 7.74e-11
GO:BP GO:1901992 positive regulation of mitotic cell cycle phase transition 19 86 7.87e-11
GO:BP GO:0006268 DNA unwinding involved in DNA replication 10 22 7.88e-11
GO:BP GO:1901989 positive regulation of cell cycle phase transition 21 103 7.88e-11
GO:BP GO:0051656 establishment of organelle localization 22 375 9.91e-11
GO:BP GO:0000022 mitotic spindle elongation 7 10 1.33e-10
GO:BP GO:1902749 regulation of cell cycle G2/M phase transition 22 102 1.74e-10
GO:BP GO:0051302 regulation of cell division 24 144 2.23e-10
GO:BP GO:1900264 positive regulation of DNA-directed DNA polymerase activity 11 13 2.48e-10
GO:BP GO:1900262 regulation of DNA-directed DNA polymerase activity 11 13 2.48e-10
GO:BP GO:0051383 kinetochore organization 9 23 3.31e-10
GO:BP GO:0051640 organelle localization 24 498 3.41e-10
GO:BP GO:0045931 positive regulation of mitotic cell cycle 23 113 3.94e-10
GO:BP GO:0051255 spindle midzone assembly 7 12 5.33e-10
GO:BP GO:0000727 double-strand break repair via break-induced replication 7 11 5.78e-10
GO:BP GO:0051052 regulation of DNA metabolic process 39 459 7.41e-10
GO:BP GO:0006310 DNA recombination 24 256 1.11e-09
GO:BP GO:0070925 organelle assembly 25 803 1.20e-09
GO:BP GO:0006302 double-strand break repair 23 270 1.30e-09
GO:BP GO:0034502 protein localization to chromosome 26 110 1.38e-09
GO:BP GO:0061982 meiosis I cell cycle process 17 80 2.59e-09
GO:BP GO:1902969 mitotic DNA replication 10 14 2.67e-09
GO:BP GO:0065004 protein-DNA complex assembly 31 185 2.72e-09
GO:BP GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 7 19 3.51e-09
GO:BP GO:0090231 regulation of spindle checkpoint 7 19 3.51e-09
GO:BP GO:1903504 regulation of mitotic spindle checkpoint 7 19 3.51e-09
GO:BP GO:0030174 regulation of DNA-templated DNA replication initiation 7 14 4.17e-09
GO:BP GO:0051128 regulation of cellular component organization 37 1947 6.86e-09
GO:BP GO:0034508 centromere complex assembly 16 30 7.37e-09
GO:BP GO:0032467 positive regulation of cytokinesis 12 33 7.86e-09
GO:BP GO:0007127 meiosis I 16 76 1.17e-08
GO:BP GO:0071824 protein-DNA complex subunit organization 20 204 1.23e-08
GO:BP GO:0030261 chromosome condensation 10 34 1.52e-08
GO:BP GO:0000724 double-strand break repair via homologous recombination 20 147 1.72e-08
GO:BP GO:0090224 regulation of spindle organization 10 45 1.86e-08
GO:BP GO:0071459 protein localization to chromosome, centromeric region 11 42 2.28e-08
GO:BP GO:0051653 spindle localization 9 52 2.35e-08
GO:BP GO:0000725 recombinational repair 20 151 2.55e-08
GO:BP GO:0007062 sister chromatid cohesion 11 51 4.52e-08
GO:BP GO:0051129 negative regulation of cellular component organization 22 586 8.09e-08
GO:BP GO:0007143 female meiotic nuclear division 6 25 8.54e-08
GO:BP GO:1901970 positive regulation of mitotic sister chromatid separation 6 18 9.99e-08
GO:BP GO:0010212 response to ionizing radiation 28 130 1.11e-07
GO:BP GO:1901978 positive regulation of cell cycle checkpoint 6 19 1.12e-07
GO:BP GO:0060236 regulation of mitotic spindle organization 9 42 1.65e-07
GO:BP GO:0051293 establishment of spindle localization 8 48 2.87e-07
GO:BP GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 13 87 3.53e-07
GO:BP GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 10 60 3.98e-07
GO:BP GO:1904029 regulation of cyclin-dependent protein kinase activity 13 90 4.82e-07
GO:BP GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint 5 12 4.95e-07
GO:BP GO:0090232 positive regulation of spindle checkpoint 5 12 4.95e-07
GO:BP GO:1902750 negative regulation of cell cycle G2/M phase transition 10 62 5.32e-07
GO:BP GO:0000076 DNA replication checkpoint signaling 9 15 5.39e-07
GO:BP GO:0071897 DNA biosynthetic process 31 175 5.53e-07
GO:BP GO:0034501 protein localization to kinetochore 7 18 5.70e-07
GO:BP GO:1903083 protein localization to condensed chromosome 7 18 5.70e-07
GO:BP GO:0007095 mitotic G2 DNA damage checkpoint signaling 8 35 5.93e-07
GO:BP GO:0006271 DNA strand elongation involved in DNA replication 9 15 6.02e-07
GO:BP GO:0040001 establishment of mitotic spindle localization 7 36 6.27e-07
GO:BP GO:0044818 mitotic G2/M transition checkpoint 9 50 7.99e-07
GO:BP GO:0071479 cellular response to ionizing radiation 11 68 8.20e-07
GO:BP GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 9 27 8.22e-07
GO:BP GO:0007098 centrosome cycle 13 126 1.17e-06
GO:BP GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore 6 11 1.67e-06
GO:BP GO:1902751 positive regulation of cell cycle G2/M phase transition 9 30 2.20e-06
GO:BP GO:0008315 G2/MI transition of meiotic cell cycle 5 5 2.63e-06
GO:BP GO:0007076 mitotic chromosome condensation 6 19 3.00e-06
GO:BP GO:0031023 microtubule organizing center organization 13 136 3.38e-06
GO:BP GO:0070507 regulation of microtubule cytoskeleton organization 13 146 3.42e-06
GO:BP GO:0045005 DNA-templated DNA replication maintenance of fidelity 12 50 3.42e-06
GO:BP GO:1903490 positive regulation of mitotic cytokinesis 5 7 3.65e-06
GO:BP GO:0044771 meiotic cell cycle phase transition 6 7 4.53e-06
GO:BP GO:0051382 kinetochore assembly 4 18 4.95e-06
GO:BP GO:0070192 chromosome organization involved in meiotic cell cycle 10 44 5.50e-06
GO:BP GO:0090235 regulation of metaphase plate congression 6 13 5.62e-06
GO:BP GO:0032506 cytokinetic process 8 39 6.94e-06
GO:BP GO:0044843 cell cycle G1/S phase transition 32 225 8.02e-06
GO:BP GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore 5 8 9.15e-06
GO:BP GO:1902423 regulation of attachment of mitotic spindle microtubules to kinetochore 5 8 9.15e-06
GO:BP GO:1902292 cell cycle DNA replication initiation 5 5 9.31e-06
GO:BP GO:1902975 mitotic DNA replication initiation 5 5 9.31e-06
GO:BP GO:1902315 nuclear cell cycle DNA replication initiation 5 5 9.31e-06
GO:BP GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 14 43 9.55e-06
GO:BP GO:0000212 meiotic spindle organization 4 14 1.60e-05
GO:BP GO:0000082 G1/S transition of mitotic cell cycle 29 203 1.63e-05
GO:BP GO:0010332 response to gamma radiation 14 50 1.70e-05
GO:BP GO:0051294 establishment of spindle orientation 6 36 1.83e-05
GO:BP GO:0072331 signal transduction by p53 class mediator 29 160 1.83e-05
GO:BP GO:0051338 regulation of transferase activity 35 713 2.59e-05
GO:BP GO:0051781 positive regulation of cell division 9 64 2.73e-05
GO:BP GO:0009314 response to radiation 45 349 2.73e-05
GO:BP GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 23 76 2.73e-05
GO:BP GO:0016321 female meiosis chromosome segregation 3 5 2.97e-05
GO:BP GO:1902412 regulation of mitotic cytokinesis 5 8 3.68e-05
GO:BP GO:0031297 replication fork processing 10 42 3.92e-05
GO:BP GO:1903934 positive regulation of DNA primase activity 5 5 4.21e-05
GO:BP GO:1903932 regulation of DNA primase activity 5 5 4.21e-05
GO:BP GO:2000001 regulation of DNA damage checkpoint 6 25 4.84e-05
GO:BP GO:0071478 cellular response to radiation 14 155 4.88e-05
GO:BP GO:0031573 mitotic intra-S DNA damage checkpoint signaling 6 15 5.07e-05
GO:BP GO:0031571 mitotic G1 DNA damage checkpoint signaling 9 27 5.44e-05
GO:BP GO:0032886 regulation of microtubule-based process 15 217 5.87e-05
GO:BP GO:0007292 female gamete generation 7 104 5.87e-05
GO:BP GO:1905832 positive regulation of spindle assembly 5 7 6.32e-05
GO:BP GO:0035825 homologous recombination 8 43 7.06e-05
GO:BP GO:0044819 mitotic G1/S transition checkpoint signaling 9 27 7.32e-05
GO:BP GO:0000132 establishment of mitotic spindle orientation 7 31 8.73e-05
GO:BP GO:1905821 positive regulation of chromosome condensation 5 5 9.48e-05
GO:BP GO:0051307 meiotic chromosome separation 3 5 1.16e-04
GO:BP GO:0007018 microtubule-based movement 11 296 1.20e-04
GO:BP GO:0044260 cellular macromolecule metabolic process 105 2777 1.20e-04
GO:BP GO:0090306 meiotic spindle assembly 3 8 1.20e-04
GO:BP GO:0071168 protein localization to chromatin 12 49 1.20e-04
GO:BP GO:0090169 regulation of spindle assembly 6 32 1.34e-04
GO:BP GO:0030330 DNA damage response, signal transduction by p53 class mediator 10 68 1.34e-04
GO:BP GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 7 16 1.37e-04
GO:BP GO:0035556 intracellular signal transduction 51 2065 1.60e-04
GO:BP GO:0036297 interstrand cross-link repair 7 37 1.76e-04
GO:BP GO:0051053 negative regulation of DNA metabolic process 14 118 2.01e-04
GO:BP GO:0000731 DNA synthesis involved in DNA repair 11 36 2.38e-04
GO:BP GO:1904668 positive regulation of ubiquitin protein ligase activity 3 11 2.49e-04
GO:BP GO:0099607 lateral attachment of mitotic spindle microtubules to kinetochore 2 2 2.54e-04
GO:BP GO:0007144 female meiosis I 5 9 2.71e-04
GO:BP GO:0006513 protein monoubiquitination 12 83 2.81e-04
GO:BP GO:0140527 reciprocal homologous recombination 7 36 2.81e-04
GO:BP GO:0007131 reciprocal meiotic recombination 7 36 2.81e-04
GO:BP GO:2000104 negative regulation of DNA-templated DNA replication 5 14 2.87e-04
GO:BP GO:0007057 spindle assembly involved in female meiosis I 4 4 2.89e-04
GO:BP GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 5 17 2.93e-04
GO:BP GO:2000045 regulation of G1/S transition of mitotic cell cycle 21 146 3.35e-04
GO:BP GO:0070601 centromeric sister chromatid cohesion 3 11 3.46e-04
GO:BP GO:0042772 DNA damage response, signal transduction resulting in transcription 5 18 3.87e-04
GO:BP GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 19 94 3.92e-04
GO:BP GO:1902806 regulation of cell cycle G1/S phase transition 23 166 4.06e-04
GO:BP GO:0007079 mitotic chromosome movement towards spindle pole 2 4 4.09e-04
GO:BP GO:0051054 positive regulation of DNA metabolic process 19 261 4.46e-04
GO:BP GO:0010032 meiotic chromosome condensation 5 6 4.70e-04
GO:BP GO:0009411 response to UV 22 137 4.84e-04
GO:BP GO:0110032 positive regulation of G2/MI transition of meiotic cell cycle 3 3 4.92e-04
GO:BP GO:0022616 DNA strand elongation 10 35 5.32e-04
GO:BP GO:0051177 meiotic sister chromatid cohesion 3 11 5.45e-04
GO:BP GO:0045144 meiotic sister chromatid segregation 3 11 5.45e-04
GO:BP GO:0001932 regulation of protein phosphorylation 34 815 5.71e-04
GO:BP GO:0051298 centrosome duplication 12 68 5.82e-04
GO:BP GO:0061983 meiosis II cell cycle process 3 12 6.69e-04
GO:BP GO:0007135 meiosis II 3 12 6.69e-04
GO:BP GO:0006468 protein phosphorylation 43 1183 7.45e-04
GO:BP GO:0051754 meiotic sister chromatid cohesion, centromeric 3 4 8.76e-04
GO:BP GO:0022414 reproductive process 32 924 9.05e-04
GO:BP GO:1904666 regulation of ubiquitin protein ligase activity 4 24 9.43e-04
GO:BP GO:0051445 regulation of meiotic cell cycle 9 45 9.58e-04
GO:BP GO:0008156 negative regulation of DNA replication 6 26 9.91e-04
GO:BP GO:0000003 reproduction 32 931 1.00e-03
GO:BP GO:0006325 chromatin organization 55 536 1.01e-03
GO:BP GO:0033314 mitotic DNA replication checkpoint signaling 5 9 1.02e-03
GO:BP GO:1902117 positive regulation of organelle assembly 14 75 1.08e-03
GO:BP GO:0045143 homologous chromosome segregation 7 33 1.13e-03
GO:BP GO:0042325 regulation of phosphorylation 36 932 1.19e-03
GO:BP GO:0031399 regulation of protein modification process 16 1207 1.22e-03
GO:BP GO:0051438 regulation of ubiquitin-protein transferase activity 4 53 1.24e-03
GO:BP GO:0071480 cellular response to gamma radiation 5 29 1.24e-03
GO:BP GO:0031109 microtubule polymerization or depolymerization 7 117 1.28e-03
GO:BP GO:0051305 chromosome movement towards spindle pole 2 7 1.28e-03
GO:BP GO:1901993 regulation of meiotic cell cycle phase transition 4 5 1.29e-03
GO:BP GO:0034080 CENP-A containing chromatin assembly 5 7 1.33e-03
GO:BP GO:0031055 chromatin remodeling at centromere 5 7 1.33e-03
GO:BP GO:2000573 positive regulation of DNA biosynthetic process 8 67 1.40e-03
GO:BP GO:0045910 negative regulation of DNA recombination 7 31 1.42e-03
GO:BP GO:0110030 regulation of G2/MI transition of meiotic cell cycle 3 3 1.72e-03
GO:BP GO:1901995 positive regulation of meiotic cell cycle phase transition 3 3 1.72e-03
GO:BP GO:2000278 regulation of DNA biosynthetic process 11 111 1.77e-03
GO:BP GO:0000915 actomyosin contractile ring assembly 3 6 1.83e-03
GO:BP GO:0000912 assembly of actomyosin apparatus involved in cytokinesis 3 6 1.83e-03
GO:BP GO:0010390 histone monoubiquitination 7 35 1.84e-03
GO:BP GO:0007056 spindle assembly involved in female meiosis 3 5 1.87e-03
GO:BP GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 13 61 1.90e-03
GO:BP GO:0007064 mitotic sister chromatid cohesion 5 29 2.07e-03
GO:BP GO:0031145 anaphase-promoting complex-dependent catabolic process 3 23 2.28e-03
GO:BP GO:0007099 centriole replication 10 38 2.38e-03
GO:BP GO:0051493 regulation of cytoskeleton organization 19 457 2.42e-03
GO:BP GO:0006334 nucleosome assembly 12 80 2.79e-03
GO:BP GO:1905784 regulation of anaphase-promoting complex-dependent catabolic process 2 4 2.80e-03
GO:BP GO:0010638 positive regulation of organelle organization 18 432 3.00e-03
GO:BP GO:1902298 cell cycle DNA replication maintenance of fidelity 2 2 3.02e-03
GO:BP GO:1990505 mitotic DNA replication maintenance of fidelity 2 2 3.02e-03
GO:BP GO:0044837 actomyosin contractile ring organization 3 7 3.02e-03
GO:BP GO:0046601 positive regulation of centriole replication 4 9 3.02e-03
GO:BP GO:1990426 mitotic recombination-dependent replication fork processing 2 2 3.02e-03
GO:BP GO:0051347 positive regulation of transferase activity 11 437 3.02e-03
GO:BP GO:0104004 cellular response to environmental stimulus 17 264 3.14e-03
GO:BP GO:0071214 cellular response to abiotic stimulus 17 264 3.14e-03
GO:BP GO:0045842 positive regulation of mitotic metaphase/anaphase transition 3 14 3.14e-03
GO:BP GO:0071900 regulation of protein serine/threonine kinase activity 16 302 3.25e-03
GO:BP GO:0060623 regulation of chromosome condensation 4 9 3.25e-03
GO:BP GO:0071163 DNA replication preinitiation complex assembly 2 3 3.26e-03
GO:BP GO:0032201 telomere maintenance via semi-conservative replication 4 8 3.34e-03
GO:BP GO:1902410 mitotic cytokinetic process 4 23 3.43e-03
GO:BP GO:0043137 DNA replication, removal of RNA primer 3 4 3.52e-03
GO:BP GO:1904776 regulation of protein localization to cell cortex 3 8 3.57e-03
GO:BP GO:1905463 negative regulation of DNA duplex unwinding 2 4 3.59e-03
GO:BP GO:1902101 positive regulation of metaphase/anaphase transition of cell cycle 3 14 3.73e-03
GO:BP GO:1903925 response to bisphenol A 3 4 4.18e-03
GO:BP GO:0016310 phosphorylation 19 1443 4.18e-03
GO:BP GO:1903926 cellular response to bisphenol A 3 4 4.18e-03
GO:BP GO:1902115 regulation of organelle assembly 20 186 4.18e-03
GO:BP GO:0046599 regulation of centriole replication 6 21 4.24e-03
GO:BP GO:0097193 intrinsic apoptotic signaling pathway 20 260 4.26e-03
GO:BP GO:0051443 positive regulation of ubiquitin-protein transferase activity 3 29 4.26e-03
GO:BP GO:0045859 regulation of protein kinase activity 22 512 4.41e-03
GO:BP GO:0000018 regulation of DNA recombination 11 101 4.42e-03
GO:BP GO:0085020 protein K6-linked ubiquitination 4 9 4.48e-03
GO:BP GO:0061952 midbody abscission 3 17 4.69e-03
GO:BP GO:0098534 centriole assembly 10 41 4.79e-03
GO:BP GO:0035518 histone H2A monoubiquitination 4 23 4.81e-03
GO:BP GO:0006566 threonine metabolic process 3 7 5.06e-03
GO:BP GO:1902807 negative regulation of cell cycle G1/S phase transition 13 67 5.14e-03
GO:BP GO:0051785 positive regulation of nuclear division 5 37 5.17e-03
GO:BP GO:0086016 AV node cell action potential 4 9 5.17e-03
GO:BP GO:0086027 AV node cell to bundle of His cell signaling 4 9 5.17e-03
GO:BP GO:0006297 nucleotide-excision repair, DNA gap filling 4 5 5.18e-03
GO:BP GO:0071364 cellular response to epidermal growth factor stimulus 5 41 5.21e-03
GO:BP GO:0045840 positive regulation of mitotic nuclear division 4 29 5.25e-03
GO:BP GO:0001934 positive regulation of protein phosphorylation 12 518 5.52e-03
GO:BP GO:0031401 positive regulation of protein modification process 13 743 5.57e-03
GO:BP GO:1905340 regulation of protein localization to kinetochore 2 4 5.90e-03
GO:BP GO:1905342 positive regulation of protein localization to kinetochore 2 4 5.90e-03
GO:BP GO:2001021 negative regulation of response to DNA damage stimulus 14 76 6.03e-03
GO:BP GO:2001020 regulation of response to DNA damage stimulus 17 292 6.17e-03
GO:BP GO:0072697 protein localization to cell cortex 3 10 6.27e-03
GO:BP GO:1901673 regulation of mitotic spindle assembly 3 23 6.27e-03
GO:BP GO:0051865 protein autoubiquitination 8 74 6.54e-03
GO:BP GO:2001252 positive regulation of chromosome organization 13 98 6.54e-03
GO:BP GO:0018107 peptidyl-threonine phosphorylation 17 97 6.60e-03
GO:BP GO:1901563 response to camptothecin 3 5 6.91e-03
GO:BP GO:0006335 DNA replication-dependent chromatin assembly 3 6 7.05e-03
GO:BP GO:1902808 positive regulation of cell cycle G1/S phase transition 7 52 7.15e-03
GO:BP GO:0007089 traversing start control point of mitotic cell cycle 3 4 7.41e-03
GO:BP GO:0070849 response to epidermal growth factor 5 44 7.57e-03
GO:BP GO:0032042 mitochondrial DNA metabolic process 5 23 7.70e-03
GO:BP GO:0000921 septin ring assembly 1 1 7.73e-03
GO:BP GO:0010824 regulation of centrosome duplication 8 44 7.99e-03
GO:BP GO:0019220 regulation of phosphate metabolic process 38 1044 8.21e-03
GO:BP GO:0048239 negative regulation of DNA recombination at telomere 2 2 8.21e-03
GO:BP GO:0072695 regulation of DNA recombination at telomere 2 2 8.21e-03
GO:BP GO:0051782 negative regulation of cell division 4 15 8.21e-03
GO:BP GO:0051174 regulation of phosphorus metabolic process 38 1045 8.25e-03
GO:BP GO:0051444 negative regulation of ubiquitin-protein transferase activity 4 21 8.30e-03
GO:BP GO:0018210 peptidyl-threonine modification 19 103 8.30e-03
GO:BP GO:0072719 cellular response to cisplatin 3 4 8.33e-03
GO:BP GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 6 42 8.56e-03
GO:BP GO:0070194 synaptonemal complex disassembly 1 2 8.99e-03
GO:BP GO:0034728 nucleosome organization 12 98 9.20e-03
GO:BP GO:0007019 microtubule depolymerization 4 43 9.50e-03
GO:BP GO:0006301 postreplication repair 7 34 9.55e-03
GO:BP GO:0035494 SNARE complex disassembly 3 3 9.75e-03
GO:BP GO:0007096 regulation of exit from mitosis 4 17 1.01e-02
GO:BP GO:0006290 pyrimidine dimer repair 1 7 1.03e-02
GO:BP GO:0086067 AV node cell to bundle of His cell communication 4 11 1.03e-02
GO:BP GO:0006338 chromatin remodeling 33 309 1.04e-02
GO:BP GO:1905462 regulation of DNA duplex unwinding 2 7 1.04e-02
GO:BP GO:0010165 response to X-ray 4 29 1.04e-02
GO:BP GO:0071139 resolution of recombination intermediates 4 6 1.07e-02
GO:BP GO:0006269 DNA replication, synthesis of RNA primer 4 6 1.07e-02
GO:BP GO:1905448 positive regulation of mitochondrial ATP synthesis coupled electron transport 2 4 1.17e-02
GO:BP GO:0042327 positive regulation of phosphorylation 12 577 1.19e-02
GO:BP GO:0042148 strand invasion 2 5 1.22e-02
GO:BP GO:0001833 inner cell mass cell proliferation 6 14 1.22e-02
GO:BP GO:1900060 negative regulation of ceramide biosynthetic process 3 5 1.23e-02
GO:BP GO:0090737 telomere maintenance via telomere trimming 4 13 1.23e-02
GO:BP GO:0001325 formation of extrachromosomal circular DNA 4 13 1.23e-02
GO:BP GO:0090656 t-circle formation 4 13 1.23e-02
GO:BP GO:0045740 positive regulation of DNA replication 10 37 1.23e-02
GO:BP GO:0046605 regulation of centrosome cycle 10 51 1.28e-02
GO:BP GO:0048478 replication fork protection 3 9 1.28e-02
GO:BP GO:0030010 establishment of cell polarity 8 131 1.30e-02
GO:BP GO:0043549 regulation of kinase activity 23 598 1.32e-02
GO:BP GO:0032954 regulation of cytokinetic process 2 3 1.34e-02
GO:BP GO:1904031 positive regulation of cyclin-dependent protein kinase activity 4 35 1.34e-02
GO:BP GO:0051642 centrosome localization 4 31 1.34e-02
GO:BP GO:0061842 microtubule organizing center localization 4 31 1.34e-02
GO:BP GO:0034421 post-translational protein acetylation 2 3 1.37e-02
GO:BP GO:1904172 positive regulation of bleb assembly 1 1 1.37e-02
GO:BP GO:0031106 septin ring organization 1 2 1.37e-02
GO:BP GO:1904170 regulation of bleb assembly 1 1 1.37e-02
GO:BP GO:0048146 positive regulation of fibroblast proliferation 4 45 1.42e-02
GO:BP GO:0046602 regulation of mitotic centrosome separation 2 8 1.43e-02
GO:BP GO:0033522 histone H2A ubiquitination 4 32 1.45e-02
GO:BP GO:0002227 innate immune response in mucosa 5 8 1.45e-02
GO:BP GO:0050790 regulation of catalytic activity 56 1783 1.49e-02
GO:BP GO:0072757 cellular response to camptothecin 2 4 1.51e-02
GO:BP GO:0001556 oocyte maturation 7 23 1.53e-02
GO:BP GO:0022412 cellular process involved in reproduction in multicellular organism 7 248 1.63e-02
GO:BP GO:0016574 histone ubiquitination 7 51 1.66e-02
GO:BP GO:0034644 cellular response to UV 4 83 1.67e-02
GO:BP GO:1903671 negative regulation of sprouting angiogenesis 3 11 1.67e-02
GO:BP GO:0062033 positive regulation of mitotic sister chromatid segregation 2 6 1.69e-02
GO:BP GO:0009265 2’-deoxyribonucleotide biosynthetic process 4 15 1.71e-02
GO:BP GO:0009263 deoxyribonucleotide biosynthetic process 4 15 1.71e-02
GO:BP GO:0046385 deoxyribose phosphate biosynthetic process 4 15 1.71e-02
GO:BP GO:0070914 UV-damage excision repair 1 13 1.72e-02
GO:BP GO:0072718 response to cisplatin 3 5 1.76e-02
GO:BP GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 7 22 1.82e-02
GO:BP GO:0071312 cellular response to alkaloid 8 29 1.87e-02
GO:BP GO:0016446 somatic hypermutation of immunoglobulin genes 4 11 1.87e-02
GO:BP GO:0031536 positive regulation of exit from mitosis 2 4 2.10e-02
GO:BP GO:0090155 negative regulation of sphingolipid biosynthetic process 3 6 2.16e-02
GO:BP GO:0072711 cellular response to hydroxyurea 4 10 2.21e-02
GO:BP GO:0034198 cellular response to amino acid starvation 6 48 2.23e-02
GO:BP GO:0007063 regulation of sister chromatid cohesion 3 20 2.30e-02
GO:BP GO:0010458 exit from mitosis 2 29 2.36e-02
GO:BP GO:0010562 positive regulation of phosphorus metabolic process 11 630 2.41e-02
GO:BP GO:0045937 positive regulation of phosphate metabolic process 11 630 2.41e-02
GO:BP GO:0006541 glutamine metabolic process 6 23 2.41e-02
GO:BP GO:0099606 microtubule plus-end directed mitotic chromosome migration 1 1 2.42e-02
GO:BP GO:0006903 vesicle targeting 11 61 2.49e-02
GO:BP GO:0010216 maintenance of DNA methylation 3 7 2.50e-02
GO:BP GO:0007163 establishment or maintenance of cell polarity 7 203 2.50e-02
GO:BP GO:1905446 regulation of mitochondrial ATP synthesis coupled electron transport 2 6 2.52e-02
GO:BP GO:0032185 septin cytoskeleton organization 1 4 2.52e-02
GO:BP GO:0002566 somatic diversification of immune receptors via somatic mutation 4 12 2.52e-02
GO:BP GO:0000002 mitochondrial genome maintenance 5 30 2.62e-02
GO:BP GO:0007077 mitotic nuclear membrane disassembly 1 7 2.63e-02
GO:BP GO:1990928 response to amino acid starvation 6 50 2.66e-02
GO:BP GO:0010457 centriole-centriole cohesion 2 14 2.67e-02
GO:BP GO:2000786 positive regulation of autophagosome assembly 5 19 2.79e-02
GO:BP GO:0072710 response to hydroxyurea 3 11 2.83e-02
GO:BP GO:0098910 regulation of atrial cardiac muscle cell action potential 3 4 2.84e-02
GO:BP GO:0006282 regulation of DNA repair 17 197 3.00e-02
GO:BP GO:0016043 cellular component organization 100 5016 3.08e-02
GO:BP GO:2000303 regulation of ceramide biosynthetic process 4 11 3.10e-02
GO:BP GO:0007100 mitotic centrosome separation 2 13 3.19e-02
GO:BP GO:0099022 vesicle tethering 7 31 3.19e-02
GO:BP GO:1904355 positive regulation of telomere capping 2 14 3.36e-02
GO:BP GO:0001578 microtubule bundle formation 4 79 3.36e-02
GO:BP GO:0051309 female meiosis chromosome separation 1 2 3.40e-02
GO:BP GO:2000105 positive regulation of DNA-templated DNA replication 4 14 3.50e-02
GO:BP GO:0043687 post-translational protein modification 9 64 3.61e-02
GO:BP GO:0051299 centrosome separation 2 14 3.62e-02
GO:BP GO:0051661 maintenance of centrosome location 2 6 3.64e-02
GO:BP GO:1904975 response to bleomycin 2 2 3.64e-02
GO:BP GO:1904976 cellular response to bleomycin 2 2 3.64e-02
GO:BP GO:0045007 depurination 1 4 3.83e-02
GO:BP GO:0006287 base-excision repair, gap-filling 5 14 3.86e-02
GO:BP GO:1990918 double-strand break repair involved in meiotic recombination 2 2 3.87e-02
GO:BP GO:0051081 nuclear membrane disassembly 1 11 3.92e-02
GO:BP GO:0016202 regulation of striated muscle tissue development 1 13 4.02e-02
GO:BP GO:0036111 very long-chain fatty-acyl-CoA metabolic process 1 2 4.02e-02
GO:BP GO:0090153 regulation of sphingolipid biosynthetic process 4 12 4.12e-02
GO:BP GO:0090521 podocyte cell migration 1 7 4.12e-02
GO:BP GO:1905038 regulation of membrane lipid metabolic process 4 12 4.12e-02
GO:BP GO:0006312 mitotic recombination 4 23 4.16e-02
GO:BP GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 6 25 4.17e-02
GO:BP GO:0030397 membrane disassembly 1 12 4.20e-02
GO:BP GO:1903416 response to glycoside 2 6 4.21e-02
GO:BP GO:0044090 positive regulation of vacuole organization 5 21 4.21e-02
GO:BP GO:0019985 translesion synthesis 7 24 4.21e-02
GO:BP GO:0072698 protein localization to microtubule cytoskeleton 4 52 4.41e-02
GO:BP GO:1905115 regulation of lateral attachment of mitotic spindle microtubules to kinetochore 1 1 4.49e-02
GO:BP GO:1905116 positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore 1 1 4.49e-02
GO:BP GO:0090435 protein localization to nuclear envelope 1 13 4.49e-02
GO:BP GO:0045004 DNA replication proofreading 2 2 4.54e-02
GO:BP GO:0051446 positive regulation of meiotic cell cycle 6 15 4.64e-02
GO:BP GO:0000722 telomere maintenance via recombination 3 15 4.64e-02
GO:BP GO:0051664 nuclear pore localization 3 4 4.81e-02
GO:BP GO:0071482 cellular response to light stimulus 4 96 4.89e-02
GO:BP GO:0044806 G-quadruplex DNA unwinding 3 7 4.94e-02
GO:BP GO:0021685 cerebellar granular layer structural organization 1 1 4.98e-02
GO:BP GO:0048634 regulation of muscle organ development 1 14 4.98e-02
KEGG KEGG:04110 Cell cycle 27 121 6.46e-22
KEGG KEGG:03030 DNA replication 17 35 3.55e-13
KEGG KEGG:04115 p53 signaling pathway 23 65 8.00e-12
KEGG KEGG:03460 Fanconi anemia pathway 10 48 1.45e-06
KEGG KEGG:03440 Homologous recombination 9 39 1.72e-05
KEGG KEGG:04114 Oocyte meiosis 9 108 2.47e-05
KEGG KEGG:04914 Progesterone-mediated oocyte maturation 10 86 7.09e-05
KEGG KEGG:04218 Cellular senescence 12 145 7.40e-05
KEGG KEGG:03430 Mismatch repair 8 22 7.40e-05
KEGG KEGG:03420 Nucleotide excision repair 8 43 1.34e-03
KEGG KEGG:03410 Base excision repair 10 33 7.77e-03
KEGG KEGG:05212 Pancreatic cancer 6 75 8.28e-03
KEGG KEGG:01524 Platinum drug resistance 6 65 1.21e-02
KEGG KEGG:05166 Human T-cell leukemia virus 1 infection 6 180 1.61e-02
KEGG KEGG:05322 Systemic lupus erythematosus 3 61 2.75e-02
KEGG KEGG:04068 FoxO signaling pathway 7 109 4.76e-02
KEGG KEGG:05216 Thyroid cancer 1 35 4.84e-02
KEGG KEGG:05203 Viral carcinogenesis 19 172 4.84e-02

AT 3 hours, the Mitoxantrone DEGs, adj. p value < 0.01, look similar to daunorubicin gene sets a 3 hours. hmmm

Venn Diagrams

All DEGs adj p value < 0.05, 24 hour

[1] 8161

All DEGs adj p value < 0.05, 3 hour

[1] 579

Because the 3 hour DEGs are low (expecially in Doxorubicin), we have chosen to focus on analyzing the 24 hour DEGs for GO: BP analysis ### Venn 3 and 24 hour sigDEGs by treatment (adj. p value <0.01) similarities

GO analysis on 24 hour Venn, adj. p value < 0.05

[1] "Number of AC drug DEG genes in common"
[1] 5155
[1] "Number of Doxorubicin specifi DEGs, adj. P value < 0.05"
[1] 342
[1] "Number of All genes that respond to some condition in DEG set, adj. P value  < 0.05"
[1] 8357
[1] "Number of No response genes in DEG set, adj. P value  < 0.05"
[1] 5727

DDE response set

adj. P value < 0.05, intersection of Dauno-Doxo-Epi, excluding those in common with Mitoxantrone n= 4915

no significant enrichment found I did the intersection of all AC drugs and found a list that was 6129 genes long. Below is that analysis.

of the AC genes that overlapped without Mito (n=4178) and all AC gens plus those which overlapped with Mito (n=5155), the significantly enriched GO: BP terms are the same. This may lend the idea that the specific AC set can tell us more about mechanism in AC induced cardiotoxicity.

DDEM response of 977

source term_id term_name intersection_size term_size p_value
GO:BP GO:1903047 mitotic cell cycle process 159 700 2.42e-34
GO:BP GO:0000278 mitotic cell cycle 177 833 2.42e-34
GO:BP GO:0022402 cell cycle process 202 1075 2.53e-28
GO:BP GO:0007049 cell cycle 255 1522 3.47e-28
GO:BP GO:0007059 chromosome segregation 100 378 1.23e-27
GO:BP GO:0000070 mitotic sister chromatid segregation 67 193 2.14e-27
GO:BP GO:0000819 sister chromatid segregation 74 234 4.84e-26
GO:BP GO:0140014 mitotic nuclear division 78 264 1.71e-25
GO:BP GO:0051301 cell division 120 567 2.02e-25
GO:BP GO:0051276 chromosome organization 125 543 4.50e-25
GO:BP GO:0010564 regulation of cell cycle process 130 620 9.24e-23
GO:BP GO:0098813 nuclear chromosome segregation 83 287 2.38e-22
GO:BP GO:0000280 nuclear division 93 354 5.07e-22
GO:BP GO:0007093 mitotic cell cycle checkpoint signaling 51 136 2.68e-21
GO:BP GO:0000075 cell cycle checkpoint signaling 59 180 3.46e-21
GO:BP GO:0051726 regulation of cell cycle 168 950 1.80e-20
GO:BP GO:0048285 organelle fission 93 397 5.54e-19
GO:BP GO:0006260 DNA replication 70 258 7.22e-19
GO:BP GO:0051983 regulation of chromosome segregation 45 118 1.76e-18
GO:BP GO:0006261 DNA-templated DNA replication 51 149 1.76e-18
GO:BP GO:0044772 mitotic cell cycle phase transition 90 413 3.57e-18
GO:BP GO:1905818 regulation of chromosome separation 34 69 7.74e-18
GO:BP GO:0045930 negative regulation of mitotic cell cycle 60 208 8.00e-18
GO:BP GO:0044770 cell cycle phase transition 101 499 1.64e-17
GO:BP GO:1901988 negative regulation of cell cycle phase transition 63 232 3.49e-17
GO:BP GO:0007346 regulation of mitotic cell cycle 92 438 7.93e-17
GO:BP GO:1901990 regulation of mitotic cell cycle phase transition 72 305 1.28e-16
GO:BP GO:0051304 chromosome separation 34 74 1.28e-16
GO:BP GO:0010948 negative regulation of cell cycle process 68 270 1.28e-16
GO:BP GO:1901987 regulation of cell cycle phase transition 84 388 2.24e-16
GO:BP GO:2000816 negative regulation of mitotic sister chromatid separation 27 47 2.54e-16
GO:BP GO:0033048 negative regulation of mitotic sister chromatid segregation 27 47 2.54e-16
GO:BP GO:0033046 negative regulation of sister chromatid segregation 27 47 2.54e-16
GO:BP GO:0033047 regulation of mitotic sister chromatid segregation 28 52 4.07e-16
GO:BP GO:1901991 negative regulation of mitotic cell cycle phase transition 50 163 4.07e-16
GO:BP GO:0045839 negative regulation of mitotic nuclear division 28 54 7.28e-16
GO:BP GO:0051985 negative regulation of chromosome segregation 27 48 8.18e-16
GO:BP GO:1905819 negative regulation of chromosome separation 27 48 8.18e-16
GO:BP GO:0045841 negative regulation of mitotic metaphase/anaphase transition 26 46 8.73e-16
GO:BP GO:0010965 regulation of mitotic sister chromatid separation 29 58 9.13e-16
GO:BP GO:1902100 negative regulation of metaphase/anaphase transition of cell cycle 26 47 3.09e-15
GO:BP GO:0071174 mitotic spindle checkpoint signaling 25 44 3.15e-15
GO:BP GO:0071173 spindle assembly checkpoint signaling 25 44 3.15e-15
GO:BP GO:0007094 mitotic spindle assembly checkpoint signaling 25 44 3.15e-15
GO:BP GO:0033045 regulation of sister chromatid segregation 37 99 3.31e-15
GO:BP GO:0051306 mitotic sister chromatid separation 29 61 3.98e-15
GO:BP GO:0031577 spindle checkpoint signaling 25 45 5.75e-15
GO:BP GO:0045786 negative regulation of cell cycle 72 334 6.63e-15
GO:BP GO:0007088 regulation of mitotic nuclear division 37 100 2.19e-14
GO:BP GO:0051784 negative regulation of nuclear division 28 57 2.42e-14
GO:BP GO:0007091 metaphase/anaphase transition of mitotic cell cycle 34 91 2.42e-14
GO:BP GO:0090068 positive regulation of cell cycle process 54 206 3.99e-14
GO:BP GO:0030071 regulation of mitotic metaphase/anaphase transition 32 88 5.95e-14
GO:BP GO:2001251 negative regulation of chromosome organization 33 90 6.13e-14
GO:BP GO:0044784 metaphase/anaphase transition of cell cycle 34 92 6.71e-14
GO:BP GO:0006974 cellular response to DNA damage stimulus 125 789 8.02e-14
GO:BP GO:0007051 spindle organization 49 186 9.37e-14
GO:BP GO:0051783 regulation of nuclear division 40 115 1.44e-13
GO:BP GO:1902099 regulation of metaphase/anaphase transition of cell cycle 32 89 1.55e-13
GO:BP GO:1902850 microtubule cytoskeleton organization involved in mitosis 44 156 2.41e-13
GO:BP GO:0033044 regulation of chromosome organization 54 233 7.02e-13
GO:BP GO:0006259 DNA metabolic process 140 890 1.13e-12
GO:BP GO:0008608 attachment of spindle microtubules to kinetochore 21 42 1.25e-12
GO:BP GO:0007052 mitotic spindle organization 30 128 2.38e-12
GO:BP GO:0006281 DNA repair 90 535 2.09e-11
GO:BP GO:0045787 positive regulation of cell cycle 62 278 3.03e-11
GO:BP GO:0031570 DNA integrity checkpoint signaling 36 126 3.33e-11
GO:BP GO:0000281 mitotic cytokinesis 26 81 5.65e-11
GO:BP GO:0051225 spindle assembly 27 118 2.06e-10
GO:BP GO:0000226 microtubule cytoskeleton organization 92 552 8.91e-10
GO:BP GO:0000910 cytokinesis 37 163 2.87e-09
GO:BP GO:0044774 mitotic DNA integrity checkpoint signaling 26 82 4.05e-09
GO:BP GO:0044839 cell cycle G2/M phase transition 36 148 7.14e-09
GO:BP GO:0032465 regulation of cytokinesis 26 79 7.89e-09
GO:BP GO:0090329 regulation of DNA-templated DNA replication 21 54 8.49e-09
GO:BP GO:0006270 DNA replication initiation 17 35 1.02e-08
GO:BP GO:0051988 regulation of attachment of spindle microtubules to kinetochore 11 18 1.06e-08
GO:BP GO:0000077 DNA damage checkpoint signaling 30 118 1.29e-08
GO:BP GO:0042770 signal transduction in response to DNA damage 39 173 1.54e-08
GO:BP GO:0051984 positive regulation of chromosome segregation 13 25 2.73e-08
GO:BP GO:0000086 G2/M transition of mitotic cell cycle 33 134 2.78e-08
GO:BP GO:1903046 meiotic cell cycle process 42 136 3.19e-08
GO:BP GO:0007080 mitotic metaphase plate congression 16 55 3.36e-08
GO:BP GO:0051255 spindle midzone assembly 9 12 3.75e-08
GO:BP GO:0051231 spindle elongation 9 12 3.75e-08
GO:BP GO:0044773 mitotic DNA damage checkpoint signaling 24 78 4.00e-08
GO:BP GO:0032508 DNA duplex unwinding 24 75 4.05e-08
GO:BP GO:0061640 cytoskeleton-dependent cytokinesis 26 103 4.12e-08
GO:BP GO:0006275 regulation of DNA replication 32 124 4.93e-08
GO:BP GO:0051310 metaphase plate congression 21 69 5.74e-08
GO:BP GO:0051383 kinetochore organization 13 23 6.24e-08
GO:BP GO:0051256 mitotic spindle midzone assembly 8 9 7.67e-08
GO:BP GO:0071459 protein localization to chromosome, centromeric region 17 42 7.96e-08
GO:BP GO:0010212 response to ionizing radiation 27 130 8.26e-08
GO:BP GO:0007017 microtubule-based process 96 756 8.26e-08
GO:BP GO:0050000 chromosome localization 23 82 1.77e-07
GO:BP GO:0032392 DNA geometric change 24 81 1.81e-07
GO:BP GO:0000022 mitotic spindle elongation 8 10 2.08e-07
GO:BP GO:0034502 protein localization to chromosome 28 110 2.58e-07
GO:BP GO:0090307 mitotic spindle assembly 17 69 3.92e-07
GO:BP GO:0010639 negative regulation of organelle organization 54 318 4.22e-07
GO:BP GO:0033043 regulation of organelle organization 112 1023 4.43e-07
GO:BP GO:0140013 meiotic nuclear division 37 121 8.28e-07
GO:BP GO:1905820 positive regulation of chromosome separation 12 26 9.35e-07
GO:BP GO:0051303 establishment of chromosome localization 21 75 1.00e-06
GO:BP GO:0071103 DNA conformation change 24 88 1.11e-06
GO:BP GO:1900262 regulation of DNA-directed DNA polymerase activity 9 13 1.18e-06
GO:BP GO:1900264 positive regulation of DNA-directed DNA polymerase activity 9 13 1.18e-06
GO:BP GO:0032467 positive regulation of cytokinesis 15 33 1.46e-06
GO:BP GO:1901976 regulation of cell cycle checkpoint 16 45 1.68e-06
GO:BP GO:0051052 regulation of DNA metabolic process 72 459 1.68e-06
GO:BP GO:0010389 regulation of G2/M transition of mitotic cell cycle 24 92 1.88e-06
GO:BP GO:0140694 non-membrane-bounded organelle assembly 54 355 2.12e-06
GO:BP GO:0051315 attachment of mitotic spindle microtubules to kinetochore 9 21 2.27e-06
GO:BP GO:0051321 meiotic cell cycle 44 188 2.31e-06
GO:BP GO:0034508 centromere complex assembly 13 30 2.57e-06
GO:BP GO:0065004 protein-DNA complex assembly 40 185 2.70e-06
GO:BP GO:0010332 response to gamma radiation 14 50 2.88e-06
GO:BP GO:1903490 positive regulation of mitotic cytokinesis 6 7 3.21e-06
GO:BP GO:0034501 protein localization to kinetochore 10 18 3.23e-06
GO:BP GO:1903083 protein localization to condensed chromosome 10 18 3.23e-06
GO:BP GO:0006541 glutamine metabolic process 4 23 3.41e-06
GO:BP GO:1902749 regulation of cell cycle G2/M phase transition 25 102 3.51e-06
GO:BP GO:0051302 regulation of cell division 28 144 6.25e-06
GO:BP GO:0045931 positive regulation of mitotic cell cycle 26 113 6.31e-06
GO:BP GO:0071824 protein-DNA complex subunit organization 41 204 8.50e-06
GO:BP GO:0006268 DNA unwinding involved in DNA replication 10 22 8.51e-06
GO:BP GO:0071478 cellular response to radiation 28 155 8.81e-06
GO:BP GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 15 43 1.28e-05
GO:BP GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator 20 76 1.90e-05
GO:BP GO:0006996 organelle organization 313 2971 2.09e-05
GO:BP GO:1901992 positive regulation of mitotic cell cycle phase transition 20 86 2.32e-05
GO:BP GO:0044786 cell cycle DNA replication 14 40 2.37e-05
GO:BP GO:1902969 mitotic DNA replication 8 14 2.73e-05
GO:BP GO:0009314 response to radiation 48 349 2.76e-05
GO:BP GO:0033554 cellular response to stress 184 1677 3.48e-05
GO:BP GO:0045132 meiotic chromosome segregation 20 69 4.12e-05
GO:BP GO:0090232 positive regulation of spindle checkpoint 7 12 4.29e-05
GO:BP GO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint 7 12 4.29e-05
GO:BP GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint 9 19 4.63e-05
GO:BP GO:0090231 regulation of spindle checkpoint 9 19 4.63e-05
GO:BP GO:1903504 regulation of mitotic spindle checkpoint 9 19 4.63e-05
GO:BP GO:0071168 protein localization to chromatin 10 49 4.78e-05
GO:BP GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore 6 11 6.34e-05
GO:BP GO:0000727 double-strand break repair via break-induced replication 7 11 6.79e-05
GO:BP GO:1902412 regulation of mitotic cytokinesis 6 8 6.97e-05
GO:BP GO:0072331 signal transduction by p53 class mediator 29 160 7.78e-05
GO:BP GO:0006271 DNA strand elongation involved in DNA replication 8 15 7.78e-05
GO:BP GO:0007098 centrosome cycle 26 126 8.20e-05
GO:BP GO:1901989 positive regulation of cell cycle phase transition 23 103 1.05e-04
GO:BP GO:0071897 DNA biosynthetic process 33 175 1.05e-04
GO:BP GO:0045005 DNA-templated DNA replication maintenance of fidelity 15 50 1.22e-04
GO:BP GO:0071479 cellular response to ionizing radiation 15 68 1.32e-04
GO:BP GO:1901978 positive regulation of cell cycle checkpoint 8 19 1.49e-04
GO:BP GO:0033260 nuclear DNA replication 12 35 1.94e-04
GO:BP GO:1902423 regulation of attachment of mitotic spindle microtubules to kinetochore 5 8 1.95e-04
GO:BP GO:1902425 positive regulation of attachment of mitotic spindle microtubules to kinetochore 5 8 1.95e-04
GO:BP GO:0008315 G2/MI transition of meiotic cell cycle 5 5 2.07e-04
GO:BP GO:0044818 mitotic G2/M transition checkpoint 14 50 2.07e-04
GO:BP GO:0000076 DNA replication checkpoint signaling 8 15 2.13e-04
GO:BP GO:0051656 establishment of organelle localization 53 375 2.16e-04
GO:BP GO:0007076 mitotic chromosome condensation 8 19 2.59e-04
GO:BP GO:0009064 glutamine family amino acid metabolic process 4 61 2.82e-04
GO:BP GO:0007062 sister chromatid cohesion 14 51 2.92e-04
GO:BP GO:0061982 meiosis I cell cycle process 25 80 3.06e-04
GO:BP GO:0006302 double-strand break repair 41 270 3.14e-04
GO:BP GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 22 87 3.19e-04
GO:BP GO:0030174 regulation of DNA-templated DNA replication initiation 7 14 3.33e-04
GO:BP GO:0031023 microtubule organizing center organization 26 136 4.14e-04
GO:BP GO:1905832 positive regulation of spindle assembly 5 7 4.44e-04
GO:BP GO:0060236 regulation of mitotic spindle organization 10 42 4.53e-04
GO:BP GO:1904029 regulation of cyclin-dependent protein kinase activity 22 90 4.80e-04
GO:BP GO:0007095 mitotic G2 DNA damage checkpoint signaling 11 35 4.80e-04
GO:BP GO:0090224 regulation of spindle organization 11 45 4.96e-04
GO:BP GO:0090235 regulation of metaphase plate congression 6 13 5.22e-04
GO:BP GO:0051640 organelle localization 63 498 5.24e-04
GO:BP GO:0010972 negative regulation of G2/M transition of mitotic cell cycle 15 60 5.75e-04
GO:BP GO:0051382 kinetochore assembly 8 18 6.89e-04
GO:BP GO:0044771 meiotic cell cycle phase transition 6 7 6.91e-04
GO:BP GO:0006310 DNA recombination 43 256 6.98e-04
GO:BP GO:0071480 cellular response to gamma radiation 8 29 7.12e-04
GO:BP GO:0000724 double-strand break repair via homologous recombination 27 147 7.18e-04
GO:BP GO:0010032 meiotic chromosome condensation 4 6 7.84e-04
GO:BP GO:1902750 negative regulation of cell cycle G2/M phase transition 15 62 8.27e-04
GO:BP GO:0071214 cellular response to abiotic stimulus 35 264 8.35e-04
GO:BP GO:0104004 cellular response to environmental stimulus 35 264 8.35e-04
GO:BP GO:1902751 positive regulation of cell cycle G2/M phase transition 10 30 8.57e-04
GO:BP GO:1905821 positive regulation of chromosome condensation 4 5 9.07e-04
GO:BP GO:0000725 recombinational repair 27 151 1.06e-03
GO:BP GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage 20 94 1.20e-03
GO:BP GO:0051129 negative regulation of cellular component organization 73 586 1.24e-03
GO:BP GO:0000912 assembly of actomyosin apparatus involved in cytokinesis 4 6 1.32e-03
GO:BP GO:0000915 actomyosin contractile ring assembly 4 6 1.32e-03
GO:BP GO:0034644 cellular response to UV 14 83 1.41e-03
GO:BP GO:0030261 chromosome condensation 12 34 1.41e-03
GO:BP GO:0009411 response to UV 19 137 1.46e-03
GO:BP GO:0030330 DNA damage response, signal transduction by p53 class mediator 7 68 1.46e-03
GO:BP GO:0031571 mitotic G1 DNA damage checkpoint signaling 9 27 1.61e-03
GO:BP GO:0000731 DNA synthesis involved in DNA repair 9 36 1.67e-03
GO:BP GO:0006334 nucleosome assembly 12 80 1.68e-03
GO:BP GO:1901970 positive regulation of mitotic sister chromatid separation 7 18 1.78e-03
GO:BP GO:0040001 establishment of mitotic spindle localization 10 36 1.80e-03
GO:BP GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 9 27 2.09e-03
GO:BP GO:0044819 mitotic G1/S transition checkpoint signaling 9 27 2.10e-03
GO:BP GO:0006513 protein monoubiquitination 14 83 2.10e-03
GO:BP GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 7 16 2.15e-03
GO:BP GO:0032506 cytokinetic process 9 39 2.34e-03
GO:BP GO:0061644 protein localization to CENP-A containing chromatin 5 17 2.35e-03
GO:BP GO:1902117 positive regulation of organelle assembly 15 75 2.47e-03
GO:BP GO:0044837 actomyosin contractile ring organization 4 7 2.75e-03
GO:BP GO:0007127 meiosis I 22 76 3.07e-03
GO:BP GO:0051053 negative regulation of DNA metabolic process 23 118 3.16e-03
GO:BP GO:0051653 spindle localization 12 52 3.29e-03
GO:BP GO:0002227 innate immune response in mucosa 4 8 3.71e-03
GO:BP GO:0034198 cellular response to amino acid starvation 7 48 4.15e-03
GO:BP GO:0035878 nail development 2 7 4.15e-03
GO:BP GO:0031297 replication fork processing 11 42 4.15e-03
GO:BP GO:0000302 response to reactive oxygen species 14 160 4.25e-03
GO:BP GO:1902292 cell cycle DNA replication initiation 3 5 4.37e-03
GO:BP GO:1902315 nuclear cell cycle DNA replication initiation 3 5 4.37e-03
GO:BP GO:1902975 mitotic DNA replication initiation 3 5 4.37e-03
GO:BP GO:0090169 regulation of spindle assembly 8 32 5.21e-03
GO:BP GO:1990928 response to amino acid starvation 7 50 5.21e-03
GO:BP GO:0035494 SNARE complex disassembly 3 3 5.33e-03
GO:BP GO:0007143 female meiotic nuclear division 9 25 6.20e-03
GO:BP GO:0051293 establishment of spindle localization 11 48 6.23e-03
GO:BP GO:0034728 nucleosome organization 12 98 6.32e-03
GO:BP GO:0110032 positive regulation of G2/MI transition of meiotic cell cycle 3 3 6.77e-03
GO:BP GO:0006301 postreplication repair 8 34 7.00e-03
GO:BP GO:0033314 mitotic DNA replication checkpoint signaling 5 9 7.00e-03
GO:BP GO:0000132 establishment of mitotic spindle orientation 7 31 7.75e-03
GO:BP GO:1903925 response to bisphenol A 3 4 7.78e-03
GO:BP GO:1903926 cellular response to bisphenol A 3 4 7.78e-03
GO:BP GO:0070925 organelle assembly 87 803 7.81e-03
GO:BP GO:0000082 G1/S transition of mitotic cell cycle 27 203 8.07e-03
GO:BP GO:1990227 paranodal junction maintenance 1 2 8.41e-03
GO:BP GO:0046601 positive regulation of centriole replication 4 9 8.74e-03
GO:BP GO:1901605 alpha-amino acid metabolic process 4 161 8.82e-03
GO:BP GO:0010638 positive regulation of organelle organization 49 432 8.86e-03
GO:BP GO:0051294 establishment of spindle orientation 9 36 9.09e-03
GO:BP GO:0051781 positive regulation of cell division 15 64 1.03e-02
GO:BP GO:0009084 glutamine family amino acid biosynthetic process 2 17 1.07e-02
GO:BP GO:0072719 cellular response to cisplatin 3 4 1.07e-02
GO:BP GO:0007089 traversing start control point of mitotic cell cycle 3 4 1.10e-02
GO:BP GO:2001021 negative regulation of response to DNA damage stimulus 15 76 1.14e-02
GO:BP GO:0051298 centrosome duplication 14 68 1.14e-02
GO:BP GO:0002385 mucosal immune response 4 11 1.20e-02
GO:BP GO:0007057 spindle assembly involved in female meiosis I 3 4 1.20e-02
GO:BP GO:0030510 regulation of BMP signaling pathway 4 84 1.37e-02
GO:BP GO:0006290 pyrimidine dimer repair 1 7 1.39e-02
GO:BP GO:0070192 chromosome organization involved in meiotic cell cycle 12 44 1.45e-02
GO:BP GO:0060623 regulation of chromosome condensation 4 9 1.46e-02
GO:BP GO:0019985 translesion synthesis 6 24 1.47e-02
GO:BP GO:0097193 intrinsic apoptotic signaling pathway 36 260 1.50e-02
GO:BP GO:0090306 meiotic spindle assembly 4 8 1.51e-02
GO:BP GO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator 7 22 1.57e-02
GO:BP GO:0022616 DNA strand elongation 9 35 1.58e-02
GO:BP GO:0085020 protein K6-linked ubiquitination 4 9 1.58e-02
GO:BP GO:0006979 response to oxidative stress 21 349 1.58e-02
GO:BP GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 6 17 1.59e-02
GO:BP GO:0071496 cellular response to external stimulus 8 268 1.61e-02
GO:BP GO:0016446 somatic hypermutation of immunoglobulin genes 5 11 1.62e-02
GO:BP GO:0033209 tumor necrosis factor-mediated signaling pathway 4 77 1.63e-02
GO:BP GO:0002251 organ or tissue specific immune response 4 13 1.63e-02
GO:BP GO:2001055 positive regulation of mesenchymal cell apoptotic process 1 2 1.67e-02
GO:BP GO:0035880 embryonic nail plate morphogenesis 1 3 1.67e-02
GO:BP GO:0051795 positive regulation of timing of catagen 1 3 1.67e-02
GO:BP GO:1901751 leukotriene A4 metabolic process 2 2 1.68e-02
GO:BP GO:2001020 regulation of response to DNA damage stimulus 37 292 1.69e-02
GO:BP GO:0016321 female meiosis chromosome segregation 3 5 1.72e-02
GO:BP GO:0098910 regulation of atrial cardiac muscle cell action potential 3 4 1.82e-02
GO:BP GO:0036297 interstrand cross-link repair 8 37 1.82e-02
GO:BP GO:0023019 signal transduction involved in regulation of gene expression 2 14 1.98e-02
GO:BP GO:0099607 lateral attachment of mitotic spindle microtubules to kinetochore 2 2 1.98e-02
GO:BP GO:0071312 cellular response to alkaloid 8 29 2.06e-02
GO:BP GO:0042772 DNA damage response, signal transduction resulting in transcription 6 18 2.08e-02
GO:BP GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 7 25 2.08e-02
GO:BP GO:0051794 regulation of timing of catagen 1 4 2.10e-02
GO:BP GO:0060364 frontal suture morphogenesis 1 4 2.10e-02
GO:BP GO:0110030 regulation of G2/MI transition of meiotic cell cycle 3 3 2.10e-02
GO:BP GO:0010824 regulation of centrosome duplication 9 44 2.10e-02
GO:BP GO:1901995 positive regulation of meiotic cell cycle phase transition 3 3 2.10e-02
GO:BP GO:0007144 female meiosis I 5 9 2.10e-02
GO:BP GO:0042637 catagen 1 4 2.10e-02
GO:BP GO:0002076 osteoblast development 2 12 2.15e-02
GO:BP GO:0009913 epidermal cell differentiation 2 114 2.17e-02
GO:BP GO:0044843 cell cycle G1/S phase transition 28 225 2.17e-02
GO:BP GO:0072718 response to cisplatin 3 5 2.18e-02
GO:BP GO:0019752 carboxylic acid metabolic process 7 679 2.18e-02
GO:BP GO:0000212 meiotic spindle organization 5 14 2.19e-02
GO:BP GO:0070914 UV-damage excision repair 1 13 2.22e-02
GO:BP GO:0002566 somatic diversification of immune receptors via somatic mutation 5 12 2.23e-02
GO:BP GO:0048818 positive regulation of hair follicle maturation 2 5 2.27e-02
GO:BP GO:0051782 negative regulation of cell division 5 15 2.27e-02
GO:BP GO:0003283 atrial septum development 5 23 2.29e-02
GO:BP GO:2000045 regulation of G1/S transition of mitotic cell cycle 20 146 2.47e-02
GO:BP GO:0043436 oxoacid metabolic process 7 698 2.49e-02
GO:BP GO:0090427 activation of meiosis 1 3 2.50e-02
GO:BP GO:0007010 cytoskeleton organization 134 1222 2.56e-02
GO:BP GO:0006082 organic acid metabolic process 7 703 2.57e-02
GO:BP GO:0006520 amino acid metabolic process 4 234 2.59e-02
GO:BP GO:2000001 regulation of DNA damage checkpoint 7 25 2.61e-02
GO:BP GO:0035825 homologous recombination 10 43 2.68e-02
GO:BP GO:0031573 mitotic intra-S DNA damage checkpoint signaling 3 15 2.73e-02
GO:BP GO:0001833 inner cell mass cell proliferation 5 14 2.78e-02
GO:BP GO:0019276 UDP-N-acetylgalactosamine metabolic process 2 2 2.80e-02
GO:BP GO:1903551 regulation of extracellular exosome assembly 3 6 2.88e-02
GO:BP GO:0032792 negative regulation of CREB transcription factor activity 1 4 2.90e-02
GO:BP GO:0072711 cellular response to hydroxyurea 4 10 2.96e-02
GO:BP GO:1904666 regulation of ubiquitin protein ligase activity 6 24 2.96e-02
GO:BP GO:0051754 meiotic sister chromatid cohesion, centromeric 3 4 2.97e-02
GO:BP GO:1901993 regulation of meiotic cell cycle phase transition 4 5 2.97e-02
GO:BP GO:0071482 cellular response to light stimulus 14 96 3.04e-02
GO:BP GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 6 20 3.08e-02
GO:BP GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 12 61 3.13e-02
GO:BP GO:0071356 cellular response to tumor necrosis factor 5 156 3.21e-02
GO:BP GO:0061312 BMP signaling pathway involved in heart development 1 7 3.29e-02
GO:BP GO:0097012 response to granulocyte macrophage colony-stimulating factor 2 6 3.32e-02
GO:BP GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus 2 6 3.32e-02
GO:BP GO:0009612 response to mechanical stimulus 10 155 3.33e-02
GO:BP GO:0072593 reactive oxygen species metabolic process 11 154 3.33e-02
GO:BP GO:1902010 negative regulation of translation in response to endoplasmic reticulum stress 1 1 3.39e-02
GO:BP GO:0035611 protein branching point deglutamylation 1 1 3.52e-02
GO:BP GO:0035518 histone H2A monoubiquitination 1 23 3.52e-02
GO:BP GO:0086016 AV node cell action potential 4 9 3.59e-02
GO:BP GO:0086027 AV node cell to bundle of His cell signaling 4 9 3.59e-02
GO:BP GO:0045617 negative regulation of keratinocyte differentiation 1 3 3.64e-02
GO:BP GO:2000104 negative regulation of DNA-templated DNA replication 5 14 3.67e-02
GO:BP GO:1904668 positive regulation of ubiquitin protein ligase activity 4 11 3.68e-02
GO:BP GO:0007064 mitotic sister chromatid cohesion 7 29 3.70e-02
GO:BP GO:0038101 sequestering of nodal from receptor via nodal binding 1 1 3.75e-02
GO:BP GO:0006970 response to osmotic stress 6 66 3.85e-02
GO:BP GO:0009628 response to abiotic stimulus 28 862 3.86e-02
GO:BP GO:0006542 glutamine biosynthetic process 1 2 3.86e-02
GO:BP GO:0042542 response to hydrogen peroxide 9 103 3.89e-02
GO:BP GO:0051438 regulation of ubiquitin-protein transferase activity 9 53 3.91e-02
GO:BP GO:0072710 response to hydroxyurea 4 11 3.92e-02
GO:BP GO:0044851 hair cycle phase 1 9 3.92e-02
GO:BP GO:0044848 biological phase 1 9 3.92e-02
GO:BP GO:0048819 regulation of hair follicle maturation 1 9 3.92e-02
GO:BP GO:0034312 diol biosynthetic process 3 20 3.92e-02
GO:BP GO:0060363 cranial suture morphogenesis 1 8 3.92e-02
GO:BP GO:0007056 spindle assembly involved in female meiosis 3 5 4.02e-02
GO:BP GO:2001170 negative regulation of ATP biosynthetic process 2 3 4.11e-02
GO:BP GO:0098901 regulation of cardiac muscle cell action potential 7 30 4.17e-02
GO:BP GO:1904975 response to bleomycin 2 2 4.19e-02
GO:BP GO:1904976 cellular response to bleomycin 2 2 4.19e-02
GO:BP GO:0006298 mismatch repair 7 29 4.21e-02
GO:BP GO:0034612 response to tumor necrosis factor 5 171 4.23e-02
GO:BP GO:0051445 regulation of meiotic cell cycle 11 45 4.24e-02
GO:BP GO:0021694 cerebellar Purkinje cell layer formation 1 12 4.24e-02
GO:BP GO:0060346 bone trabecula formation 1 9 4.24e-02
GO:BP GO:0071971 extracellular exosome assembly 3 6 4.24e-02
GO:BP GO:0002072 optic cup morphogenesis involved in camera-type eye development 2 4 4.31e-02
GO:BP GO:0008544 epidermis development 2 207 4.36e-02
GO:BP GO:0030509 BMP signaling pathway 4 123 4.45e-02
GO:BP GO:0033522 histone H2A ubiquitination 1 32 4.45e-02
GO:BP GO:0051128 regulation of cellular component organization 125 1947 4.47e-02
GO:BP GO:0046605 regulation of centrosome cycle 9 51 4.54e-02
GO:BP GO:0019372 lipoxygenase pathway 3 5 4.57e-02
GO:BP GO:1903779 regulation of cardiac conduction 6 23 4.61e-02
GO:BP GO:0044260 cellular macromolecule metabolic process 262 2777 4.61e-02
GO:BP GO:0032223 negative regulation of synaptic transmission, cholinergic 1 1 4.61e-02
GO:BP GO:0050910 detection of mechanical stimulus involved in sensory perception of sound 1 8 4.61e-02
GO:BP GO:0044210 ‘de novo’ CTP biosynthetic process 1 2 4.61e-02
GO:BP GO:0045217 cell-cell junction maintenance 1 13 4.61e-02
GO:BP GO:0071619 phosphorylation of RNA polymerase II C-terminal domain serine 2 residues 2 3 4.65e-02
GO:BP GO:0046173 polyol biosynthetic process 5 47 4.71e-02
GO:BP GO:0010390 histone monoubiquitination 1 35 4.71e-02
GO:BP GO:0006914 autophagy 38 507 4.77e-02
GO:BP GO:0061919 process utilizing autophagic mechanism 38 507 4.77e-02
GO:BP GO:0009267 cellular response to starvation 11 151 4.78e-02
GO:BP GO:0060088 auditory receptor cell stereocilium organization 1 9 4.78e-02
GO:BP GO:0051798 positive regulation of hair follicle development 1 9 4.78e-02
GO:BP GO:0019731 antibacterial humoral response 4 15 4.81e-02
GO:BP GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 11 99 4.85e-02
GO:BP GO:0010800 positive regulation of peptidyl-threonine phosphorylation 3 23 4.87e-02
GO:BP GO:0006297 nucleotide-excision repair, DNA gap filling 3 5 4.87e-02
GO:BP GO:0070601 centromeric sister chromatid cohesion 4 11 4.89e-02
GO:BP GO:0071364 cellular response to epidermal growth factor stimulus 5 41 4.89e-02
GO:BP GO:0008156 negative regulation of DNA replication 7 26 4.90e-02
GO:BP GO:0021692 cerebellar Purkinje cell layer morphogenesis 1 16 4.94e-02
GO:BP GO:0045683 negative regulation of epidermis development 1 6 4.96e-02
GO:BP GO:0061430 bone trabecula morphogenesis 1 12 4.96e-02
GO:BP GO:0048598 embryonic morphogenesis 3 440 4.96e-02
GO:BP GO:0045605 negative regulation of epidermal cell differentiation 1 6 4.96e-02
GO:BP GO:2001053 regulation of mesenchymal cell apoptotic process 1 5 4.96e-02
GO:BP GO:0051100 negative regulation of binding 2 136 4.96e-02
GO:BP GO:0046338 phosphatidylethanolamine catabolic process 2 4 4.96e-02
GO:BP GO:0046340 diacylglycerol catabolic process 2 3 4.96e-02
KEGG KEGG:04110 Cell cycle 35 121 1.89e-10
KEGG KEGG:04115 p53 signaling pathway 24 65 6.99e-09
KEGG KEGG:03030 DNA replication 16 35 3.09e-08
KEGG KEGG:03430 Mismatch repair 9 22 5.05e-04
KEGG KEGG:03440 Homologous recombination 10 39 1.09e-03
KEGG KEGG:05322 Systemic lupus erythematosus 13 61 1.09e-03
KEGG KEGG:05034 Alcoholism 9 122 2.23e-03
KEGG KEGG:04217 Necroptosis 5 106 3.64e-03
KEGG KEGG:03460 Fanconi anemia pathway 12 48 4.27e-03
KEGG KEGG:04613 Neutrophil extracellular trap formation 5 110 4.27e-03
KEGG KEGG:04964 Proximal tubule bicarbonate reclamation 2 20 1.25e-02
KEGG KEGG:03420 Nucleotide excision repair 10 43 1.64e-02
KEGG KEGG:01524 Platinum drug resistance 11 65 1.97e-02
KEGG KEGG:03410 Base excision repair 8 33 2.64e-02

What I will do is take the terms from the tope three KEGG pathways and look at count changes or at FC values. Updated later.

DXspecific response (only the subset unique to Dox)

Whoa! look at the calcium things

source term_id term_name intersection_size term_size p_value
GO:BP GO:2001258 negative regulation of cation channel activity 5 30 8.98e-03
GO:BP GO:0034763 negative regulation of transmembrane transport 8 95 8.98e-03
GO:BP GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity 4 23 8.98e-03
GO:BP GO:1901020 negative regulation of calcium ion transmembrane transporter activity 5 27 1.11e-02
GO:BP GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity 3 10 1.20e-02
GO:BP GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion 4 20 1.30e-02
GO:BP GO:0032413 negative regulation of ion transmembrane transporter activity 6 51 1.31e-02
GO:BP GO:0051280 negative regulation of release of sequestered calcium ion into cytosol 3 11 1.31e-02
GO:BP GO:1903170 negative regulation of calcium ion transmembrane transport 5 35 1.57e-02
GO:BP GO:0051284 positive regulation of sequestering of calcium ion 3 13 1.57e-02
GO:BP GO:0032410 negative regulation of transporter activity 6 58 1.57e-02
GO:BP GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling 4 25 1.57e-02
GO:BP GO:1904063 negative regulation of cation transmembrane transport 6 64 2.11e-02
GO:BP GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 4 27 2.11e-02
GO:BP GO:1901019 regulation of calcium ion transmembrane transporter activity 5 71 2.15e-02
GO:BP GO:0034766 negative regulation of monoatomic ion transmembrane transport 6 69 2.80e-02
GO:BP GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 4 28 2.91e-02
GO:BP GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 4 28 3.10e-02
GO:BP GO:2001257 regulation of cation channel activity 6 98 3.15e-02
GO:BP GO:0051926 negative regulation of calcium ion transport 5 45 3.31e-02

I feel a little dumb for not remembering this results on Wednesday…. now that I ran this using the new adj. p value of < 0.05, I am more confident they are consistent. as above, I will pull the specific genes and look at logCPM of these genes soon to examine if the change is seen in the other AC genes at 24 hours.

No Response genes n=5727

source term_id term_name intersection_size term_size p_value
GO:BP GO:0009100 glycoprotein metabolic process 174 317 4.39e-04
GO:BP GO:0022904 respiratory electron transport chain 67 103 5.22e-04
GO:BP GO:0045229 external encapsulating structure organization 131 231 5.22e-04
GO:BP GO:0019646 aerobic electron transport chain 52 74 5.22e-04
GO:BP GO:0030198 extracellular matrix organization 130 230 5.22e-04
GO:BP GO:0043062 extracellular structure organization 130 231 6.06e-04
GO:BP GO:0042773 ATP synthesis coupled electron transport 55 82 8.58e-04
GO:BP GO:0042775 mitochondrial ATP synthesis coupled electron transport 55 82 8.58e-04
GO:BP GO:0006486 protein glycosylation 107 189 2.71e-03
GO:BP GO:0043413 macromolecule glycosylation 107 189 2.71e-03
GO:BP GO:0070085 glycosylation 114 204 2.76e-03
GO:BP GO:0006812 monoatomic cation transport 323 668 3.62e-03
GO:BP GO:0006811 monoatomic ion transport 367 774 7.37e-03
GO:BP GO:0009101 glycoprotein biosynthetic process 135 254 9.85e-03
GO:BP GO:0006119 oxidative phosphorylation 78 134 1.06e-02
GO:BP GO:0002181 cytoplasmic translation 88 155 1.12e-02
GO:BP GO:0022900 electron transport chain 81 141 1.26e-02
GO:BP GO:0007160 cell-matrix adhesion 99 179 1.35e-02
GO:BP GO:0009060 aerobic respiration 99 180 1.73e-02
GO:BP GO:0007229 integrin-mediated signaling pathway 54 89 3.50e-02
GO:BP GO:0030001 metal ion transport 269 563 3.59e-02
GO:BP GO:0055085 transmembrane transport 455 996 3.59e-02
GO:BP GO:0045333 cellular respiration 117 222 3.59e-02
GO:BP GO:0010466 negative regulation of peptidase activity 83 149 3.59e-02
GO:BP GO:0098655 monoatomic cation transmembrane transport 259 541 3.75e-02
GO:BP GO:1901135 carbohydrate derivative metabolic process 413 899 3.99e-02
GO:BP GO:0034220 monoatomic ion transmembrane transport 298 633 4.66e-02
GO:BP GO:0034645 cellular macromolecule biosynthetic process 468 1030 4.66e-02
KEGG KEGG:03010 Ribosome 84 127 6.40e-07
KEGG KEGG:05171 Coronavirus disease - COVID-19 100 162 2.53e-06
KEGG KEGG:04510 Focal adhesion 105 175 6.34e-06
KEGG KEGG:04512 ECM-receptor interaction 48 69 4.97e-05
KEGG KEGG:05415 Diabetic cardiomyopathy 98 169 9.70e-05
KEGG KEGG:00190 Oxidative phosphorylation 65 106 3.78e-04
KEGG KEGG:00531 Glycosaminoglycan degradation 15 16 5.15e-04
KEGG KEGG:04714 Thermogenesis 107 195 6.63e-04
KEGG KEGG:05012 Parkinson disease 120 226 1.34e-03
KEGG KEGG:04810 Regulation of actin cytoskeleton 98 179 1.34e-03
KEGG KEGG:05208 Chemical carcinogenesis - reactive oxygen species 101 186 1.46e-03
KEGG KEGG:05020 Prion disease 114 220 6.11e-03
KEGG KEGG:04151 PI3K-Akt signaling pathway 129 254 6.95e-03
KEGG KEGG:05146 Amoebiasis 39 64 1.33e-02
KEGG KEGG:04141 Protein processing in endoplasmic reticulum 85 161 1.36e-02
KEGG KEGG:04932 Non-alcoholic fatty liver disease 71 131 1.36e-02
KEGG KEGG:00000 KEGG root term 2295 5534 2.43e-02
KEGG KEGG:04066 HIF-1 signaling pathway 50 89 2.63e-02
KEGG KEGG:05205 Proteoglycans in cancer 87 170 3.21e-02
KEGG KEGG:04260 Cardiac muscle contraction 39 67 3.21e-02
KEGG KEGG:05414 Dilated cardiomyopathy 44 78 3.82e-02

##GO:BP full figure 24 DEG analysis

##Visualization of FC in cormotif sets


Attaching package: 'limma'
The following object is masked from 'package:BiocGenerics':

    plotMA
corrplot 0.92 loaded
[1] TRUE

##CVRI poster figures not run


R version 4.2.2 (2022-10-31 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19044)

Matrix products: default

locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

attached base packages:
[1] grid      stats     graphics  grDevices utils     datasets  methods  
[8] base     

other attached packages:
 [1] RColorBrewer_1.1-3  pheatmap_1.0.12     corrplot_0.92      
 [4] limma_3.52.4        ggpubr_0.6.0        cowplot_1.1.1      
 [7] ggVennDiagram_1.2.2 scales_1.2.1        kableExtra_1.3.4   
[10] VennDiagram_1.7.3   futile.logger_1.4.3 gridExtra_2.3      
[13] BiocGenerics_0.42.0 gprofiler2_0.2.1    lubridate_1.9.2    
[16] forcats_1.0.0       stringr_1.5.0       dplyr_1.1.0        
[19] purrr_1.0.1         readr_2.1.4         tidyr_1.3.0        
[22] tibble_3.1.8        ggplot2_3.4.1       tidyverse_2.0.0    
[25] workflowr_1.7.0    

loaded via a namespace (and not attached):
 [1] colorspace_2.1-0     ggsignif_0.6.4       ellipsis_0.3.2      
 [4] class_7.3-21         rprojroot_2.0.3      fs_1.6.1            
 [7] rstudioapi_0.14      proxy_0.4-27         farver_2.1.1        
[10] bit64_4.0.5          fansi_1.0.4          xml2_1.3.3          
[13] cachem_1.0.7         knitr_1.42           jsonlite_1.8.4      
[16] broom_1.0.3          shiny_1.7.4          compiler_4.2.2      
[19] httr_1.4.5           backports_1.4.1      fastmap_1.1.1       
[22] lazyeval_0.2.2       cli_3.6.0            later_1.3.0         
[25] formatR_1.14         htmltools_0.5.4      tools_4.2.2         
[28] gtable_0.3.1         glue_1.6.2           Rcpp_1.0.10         
[31] carData_3.0-5        jquerylib_0.1.4      vctrs_0.5.2         
[34] svglite_2.1.1        crosstalk_1.2.0      xfun_0.37           
[37] ps_1.7.2             rvest_1.0.3          timechange_0.2.0    
[40] mime_0.12            lifecycle_1.0.3      rstatix_0.7.2       
[43] getPass_0.2-2        vroom_1.6.1          hms_1.1.2           
[46] promises_1.2.0.1     parallel_4.2.2       lambda.r_1.2.4      
[49] yaml_2.3.7           sass_0.4.5           stringi_1.7.12      
[52] highr_0.10           e1071_1.7-13         rlang_1.0.6         
[55] pkgconfig_2.0.3      systemfonts_1.0.4    evaluate_0.20       
[58] sf_1.0-9             htmlwidgets_1.6.1    labeling_0.4.2      
[61] bit_4.0.5            processx_3.8.0       tidyselect_1.2.0    
[64] magrittr_2.0.3       R6_2.5.1             generics_0.1.3      
[67] DBI_1.1.3            pillar_1.8.1         whisker_0.4.1       
[70] withr_2.5.0          units_0.8-1          abind_1.4-5         
[73] crayon_1.5.2         car_3.1-1            futile.options_1.0.1
[76] KernSmooth_2.23-20   utf8_1.2.3           plotly_4.10.1       
[79] RVenn_1.1.0          tzdb_0.3.0           rmarkdown_2.20      
[82] data.table_1.14.8    callr_3.7.3          git2r_0.31.0        
[85] digest_0.6.31        classInt_0.4-9       webshot_0.5.4       
[88] xtable_1.8-4         httpuv_1.6.9         munsell_0.5.0       
[91] viridisLite_0.4.1    bslib_0.4.2