Jaspar_motif

Last updated: 2025-07-08

Checks: 7 0

Knit directory: ATAC_learning/

This reproducible R Markdown analysis was created with workflowr (version 1.7.1). The Checks tab describes the reproducibility checks that were applied when the results were created. The Past versions tab lists the development history.

R Markdown file: up-to-date

Great! Since the R Markdown file has been committed to the Git repository, you know the exact version of the code that produced these results.

Environment: empty

Great job! The global environment was empty. Objects defined in the global environment can affect the analysis in your R Markdown file in unknown ways. For reproduciblity it’s best to always run the code in an empty environment.

Seed: set.seed(20231016)

The command set.seed(20231016) was run prior to running the code in the R Markdown file. Setting a seed ensures that any results that rely on randomness, e.g. subsampling or permutations, are reproducible.

Session information: recorded

Great job! Recording the operating system, R version, and package versions is critical for reproducibility.

Cache: none

Nice! There were no cached chunks for this analysis, so you can be confident that you successfully produced the results during this run.

File paths: relative

Great job! Using relative paths to the files within your workflowr project makes it easier to run your code on other machines.

Repository version: a197405

Great! You are using Git for version control. Tracking code development and connecting the code version to the results is critical for reproducibility.

The results in this page were generated with repository version a197405. See the Past versions tab to see a history of the changes made to the R Markdown and HTML files.

Note that you need to be careful to ensure that all relevant files for the analysis have been committed to Git prior to generating the results (you can use wflow_publish or wflow_git_commit). workflowr only checks the R Markdown file, but you know if there are other scripts or data files that it depends on. Below is the status of the Git repository when the results were generated:


Ignored files:
    Ignored:    .RData
    Ignored:    .Rhistory
    Ignored:    .Rproj.user/
    Ignored:    analysis/H3K27ac_integration_noM.Rmd
    Ignored:    data/ACresp_SNP_table.csv
    Ignored:    data/ARR_SNP_table.csv
    Ignored:    data/All_merged_peaks.tsv
    Ignored:    data/CAD_gwas_dataframe.RDS
    Ignored:    data/CTX_SNP_table.csv
    Ignored:    data/Collapsed_expressed_NG_peak_table.csv
    Ignored:    data/DEG_toplist_sep_n45.RDS
    Ignored:    data/FRiP_first_run.txt
    Ignored:    data/Final_four_data/
    Ignored:    data/Frip_1_reads.csv
    Ignored:    data/Frip_2_reads.csv
    Ignored:    data/Frip_3_reads.csv
    Ignored:    data/Frip_4_reads.csv
    Ignored:    data/Frip_5_reads.csv
    Ignored:    data/Frip_6_reads.csv
    Ignored:    data/GO_KEGG_analysis/
    Ignored:    data/HF_SNP_table.csv
    Ignored:    data/Ind1_75DA24h_dedup_peaks.csv
    Ignored:    data/Ind1_TSS_peaks.RDS
    Ignored:    data/Ind1_firstfragment_files.txt
    Ignored:    data/Ind1_fragment_files.txt
    Ignored:    data/Ind1_peaks_list.RDS
    Ignored:    data/Ind1_summary.txt
    Ignored:    data/Ind2_TSS_peaks.RDS
    Ignored:    data/Ind2_fragment_files.txt
    Ignored:    data/Ind2_peaks_list.RDS
    Ignored:    data/Ind2_summary.txt
    Ignored:    data/Ind3_TSS_peaks.RDS
    Ignored:    data/Ind3_fragment_files.txt
    Ignored:    data/Ind3_peaks_list.RDS
    Ignored:    data/Ind3_summary.txt
    Ignored:    data/Ind4_79B24h_dedup_peaks.csv
    Ignored:    data/Ind4_TSS_peaks.RDS
    Ignored:    data/Ind4_V24h_fraglength.txt
    Ignored:    data/Ind4_fragment_files.txt
    Ignored:    data/Ind4_fragment_filesN.txt
    Ignored:    data/Ind4_peaks_list.RDS
    Ignored:    data/Ind4_summary.txt
    Ignored:    data/Ind5_TSS_peaks.RDS
    Ignored:    data/Ind5_fragment_files.txt
    Ignored:    data/Ind5_fragment_filesN.txt
    Ignored:    data/Ind5_peaks_list.RDS
    Ignored:    data/Ind5_summary.txt
    Ignored:    data/Ind6_TSS_peaks.RDS
    Ignored:    data/Ind6_fragment_files.txt
    Ignored:    data/Ind6_peaks_list.RDS
    Ignored:    data/Ind6_summary.txt
    Ignored:    data/Knowles_4.RDS
    Ignored:    data/Knowles_5.RDS
    Ignored:    data/Knowles_6.RDS
    Ignored:    data/LiSiLTDNRe_TE_df.RDS
    Ignored:    data/MI_gwas.RDS
    Ignored:    data/SNP_GWAS_PEAK_MRC_id
    Ignored:    data/SNP_GWAS_PEAK_MRC_id.csv
    Ignored:    data/SNP_gene_cat_list.tsv
    Ignored:    data/SNP_supp_schneider.RDS
    Ignored:    data/TE_info/
    Ignored:    data/TFmapnames.RDS
    Ignored:    data/all_TSSE_scores.RDS
    Ignored:    data/all_four_filtered_counts.txt
    Ignored:    data/aln_run1_results.txt
    Ignored:    data/anno_ind1_DA24h.RDS
    Ignored:    data/anno_ind4_V24h.RDS
    Ignored:    data/annotated_gwas_SNPS.csv
    Ignored:    data/background_n45_he_peaks.RDS
    Ignored:    data/cardiac_muscle_FRIP.csv
    Ignored:    data/cardiomyocyte_FRIP.csv
    Ignored:    data/col_ng_peak.csv
    Ignored:    data/cormotif_full_4_run.RDS
    Ignored:    data/cormotif_full_4_run_he.RDS
    Ignored:    data/cormotif_full_6_run.RDS
    Ignored:    data/cormotif_full_6_run_he.RDS
    Ignored:    data/cormotif_probability_45_list.csv
    Ignored:    data/cormotif_probability_45_list_he.csv
    Ignored:    data/cormotif_probability_all_6_list.csv
    Ignored:    data/cormotif_probability_all_6_list_he.csv
    Ignored:    data/datasave.RDS
    Ignored:    data/embryo_heart_FRIP.csv
    Ignored:    data/enhancer_list_ENCFF126UHK.bed
    Ignored:    data/enhancerdata/
    Ignored:    data/filt_Peaks_efit2.RDS
    Ignored:    data/filt_Peaks_efit2_bl.RDS
    Ignored:    data/filt_Peaks_efit2_n45.RDS
    Ignored:    data/first_Peaksummarycounts.csv
    Ignored:    data/first_run_frag_counts.txt
    Ignored:    data/full_bedfiles/
    Ignored:    data/gene_ref.csv
    Ignored:    data/gwas_1_dataframe.RDS
    Ignored:    data/gwas_2_dataframe.RDS
    Ignored:    data/gwas_3_dataframe.RDS
    Ignored:    data/gwas_4_dataframe.RDS
    Ignored:    data/gwas_5_dataframe.RDS
    Ignored:    data/high_conf_peak_counts.csv
    Ignored:    data/high_conf_peak_counts.txt
    Ignored:    data/high_conf_peaks_bl_counts.txt
    Ignored:    data/high_conf_peaks_counts.txt
    Ignored:    data/hits_files/
    Ignored:    data/hyper_files/
    Ignored:    data/hypo_files/
    Ignored:    data/ind1_DA24hpeaks.RDS
    Ignored:    data/ind1_TSSE.RDS
    Ignored:    data/ind2_TSSE.RDS
    Ignored:    data/ind3_TSSE.RDS
    Ignored:    data/ind4_TSSE.RDS
    Ignored:    data/ind4_V24hpeaks.RDS
    Ignored:    data/ind5_TSSE.RDS
    Ignored:    data/ind6_TSSE.RDS
    Ignored:    data/initial_complete_stats_run1.txt
    Ignored:    data/left_ventricle_FRIP.csv
    Ignored:    data/median_24_lfc.RDS
    Ignored:    data/median_3_lfc.RDS
    Ignored:    data/mergedPeads.gff
    Ignored:    data/mergedPeaks.gff
    Ignored:    data/motif_list_full
    Ignored:    data/motif_list_n45
    Ignored:    data/motif_list_n45.RDS
    Ignored:    data/multiqc_fastqc_run1.txt
    Ignored:    data/multiqc_fastqc_run2.txt
    Ignored:    data/multiqc_genestat_run1.txt
    Ignored:    data/multiqc_genestat_run2.txt
    Ignored:    data/my_hc_filt_counts.RDS
    Ignored:    data/my_hc_filt_counts_n45.RDS
    Ignored:    data/n45_bedfiles/
    Ignored:    data/n45_files
    Ignored:    data/other_papers/
    Ignored:    data/peakAnnoList_1.RDS
    Ignored:    data/peakAnnoList_2.RDS
    Ignored:    data/peakAnnoList_24_full.RDS
    Ignored:    data/peakAnnoList_24_n45.RDS
    Ignored:    data/peakAnnoList_3.RDS
    Ignored:    data/peakAnnoList_3_full.RDS
    Ignored:    data/peakAnnoList_3_n45.RDS
    Ignored:    data/peakAnnoList_4.RDS
    Ignored:    data/peakAnnoList_5.RDS
    Ignored:    data/peakAnnoList_6.RDS
    Ignored:    data/peakAnnoList_Eight.RDS
    Ignored:    data/peakAnnoList_full_motif.RDS
    Ignored:    data/peakAnnoList_n45_motif.RDS
    Ignored:    data/siglist_full.RDS
    Ignored:    data/siglist_n45.RDS
    Ignored:    data/summarized_peaks_dataframe.txt
    Ignored:    data/summary_peakIDandReHeat.csv
    Ignored:    data/test.list.RDS
    Ignored:    data/testnames.txt
    Ignored:    data/toplist_6.RDS
    Ignored:    data/toplist_full.RDS
    Ignored:    data/toplist_full_DAR_6.RDS
    Ignored:    data/toplist_n45.RDS
    Ignored:    data/trimmed_seq_length.csv
    Ignored:    data/unclassified_full_set_peaks.RDS
    Ignored:    data/unclassified_n45_set_peaks.RDS
    Ignored:    data/xstreme/

Untracked files:
    Untracked:  RNA_seq_integration.Rmd
    Untracked:  Rplot.pdf
    Untracked:  Sig_meta
    Untracked:  analysis/.gitignore
    Untracked:  analysis/AF_HF_SNP_DAR.Rmd
    Untracked:  analysis/Cormotif_analysis_testing diff.Rmd
    Untracked:  analysis/Diagnosis-tmm.Rmd
    Untracked:  analysis/Expressed_RNA_associations.Rmd
    Untracked:  analysis/LFC_corr.Rmd
    Untracked:  analysis/SNP_TAD_peaks.Rmd
    Untracked:  analysis/SVA.Rmd
    Untracked:  analysis/Tan2020.Rmd
    Untracked:  analysis/Top2B_analysis.Rmd
    Untracked:  analysis/making_master_peaks_list.Rmd
    Untracked:  analysis/my_hc_filt_counts.csv
    Untracked:  code/Concatenations_for_export.R
    Untracked:  code/IGV_snapshot_code.R
    Untracked:  code/LongDARlist.R
    Untracked:  code/just_for_Fun.R
    Untracked:  my_plot.pdf
    Untracked:  my_plot.png
    Untracked:  output/cormotif_probability_45_list.csv
    Untracked:  output/cormotif_probability_all_6_list.csv
    Untracked:  setup.RData

Unstaged changes:
    Modified:   ATAC_learning.Rproj
    Modified:   analysis/AF_HF_SNPs.Rmd
    Modified:   analysis/Cardiotox_SNPs.Rmd
    Modified:   analysis/Cormotif_analysis.Rmd
    Modified:   analysis/DEG_analysis.Rmd
    Modified:   analysis/H3K27ac_initial_QC.Rmd
    Modified:   analysis/H3K27ac_integration.Rmd
    Modified:   analysis/Jaspar_motif.Rmd
    Modified:   analysis/Jaspar_motif_ff.Rmd
    Modified:   analysis/TE_analysis_norm.Rmd
    Modified:   analysis/final_four_analysis.Rmd

Note that any generated files, e.g. HTML, png, CSS, etc., are not included in this status report because it is ok for generated content to have uncommitted changes.

These are the previous versions of the repository in which changes were made to the R Markdown (analysis/Jaspar_motif_DAR.Rmd) and HTML (docs/Jaspar_motif_DAR.html) files. If you’ve configured a remote Git repository (see ?wflow_git_remote), click on the hyperlinks in the table below to view the files as they were in that past version.

File	Version	Author	Date	Message
Rmd	a197405	reneeisnowhere	2025-07-08	wflow_publish("analysis/Jaspar_motif_DAR.Rmd")
html	53f3fdc	reneeisnowhere	2025-07-01	Build site.
Rmd	be98936	reneeisnowhere	2025-07-01	updates
Rmd	26eb8eb	reneeisnowhere	2025-06-23	adding updates

library(tidyverse)
library(cowplot)
library(kableExtra)
library(broom)
library(RColorBrewer)
library(ChIPseeker)
library("TxDb.Hsapiens.UCSC.hg38.knownGene")
library("org.Hs.eg.db")
library(rtracklayer)
library(edgeR)
library(ggfortify)
library(limma)
library(readr)
library(BiocGenerics)
library(gridExtra)
library(VennDiagram)
library(scales)
library(Cormotif)
library(BiocParallel)
library(ggpubr)
library(devtools)
library(JASPAR2022)
# library(TFBSTools)
library(MotifDb)
library(BSgenome.Hsapiens.UCSC.hg38)
library(data.table)
library(universalmotif)
library(ggseqlogo)
# library(motifmatchr)
library(gridExtra)

# mrc_palette <- c(
#     "EAR_open" = "#F8766D",
#     "EAR_close" = "#f6483c",
#     "ESR_open" = "#7CAE00",
#     "ESR_close" = "#587b00",
#     "ESR_C"="grey40",
#      "ESR_opcl"="grey40",
#     "ESR_D"="tan",
#      "ESR_clop"="tan",
#      "LR_open" = "#00BFC4",
#      "LR_close" = "#008d91",
#      "NR" = "#C77CFF"
#   )

DOX

DOX_DAR_3hr data

DOX_DAR_3hr_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_3_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DOX_DAR_3hr_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_3_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DOX_DAR_3hr_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_3_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DOX_DAR_3hr_all <- rbind(DOX_DAR_3hr_sea_disc, DOX_DAR_3hr_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DOX_DAR_3hr_combo <- DOX_DAR_3hr_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DOX_DAR_3hr_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ NA_character_
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="DOX_DAR_3hr")

DOX_DAR_3hr_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs in 3 hour DOX-DAR v 3 hour non-DOX DAR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs in 3 hour DOX-DAR v 3 hour non-DOX DAR
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA1630.2 (ZNF281)	STREME-2	2-CCCCWCCCC	CCCCWCCCC	ZNF281	2.3e-83	1.82e-83	1040	33.1	24900	18.2	1.82	DOX_DAR_3hr
2	1	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	2.48e-66	9.82e-67	1570	50.2	47400	34.6	1.45	DOX_DAR_3hr
3	1	MA1630.2 (ZNF281)	MEME-1	GGGWGGGGGSGGGGG	GGGWGGGGGSGGGGG	ZNF281	8.82e-64	2.33e-64	1240	39.6	34700	25.4	1.56	DOX_DAR_3hr
4	1	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	2.61e-61	5.16e-62	1160	37	31900	23.3	1.59	DOX_DAR_3hr
5	1	MA1653.1 (ZNF148)	STREME-5	5-CCCTCCC	CCCTCCC	ZNF148	8.33e-60	1.32e-60	1860	59.4	60700	44.3	1.34	DOX_DAR_3hr
6	1	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	6.29e-59	8.31e-60	1650	52.7	51800	37.9	1.39	DOX_DAR_3hr
7	1	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	2.2e-58	2.49e-59	1040	33.2	27900	20.4	1.63	DOX_DAR_3hr
8	1	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	8.48e-57	8.4e-58	1460	46.7	44500	32.5	1.44	DOX_DAR_3hr
9	1	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	5.29e-55	4.66e-56	1200	38.4	34500	25.2	1.52	DOX_DAR_3hr
10	1	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	9.43e-53	7.47e-54	1640	52.4	52600	38.4	1.37	DOX_DAR_3hr
11	1	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	3.83e-52	2.76e-53	1340	42.8	40400	29.5	1.45	DOX_DAR_3hr
12	2	MA0742.2 (KLF12)	MEME-3	CCCAGCCC	CCCAGCCC	KLF12	1.13e-51	7.49e-53	1650	52.8	53300	38.9	1.36	DOX_DAR_3hr
13	1	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	2.27e-49	1.38e-50	1690	54.2	55500	40.5	1.34	DOX_DAR_3hr
14	1	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	5.78e-47	3.27e-48	1680	53.8	55400	40.5	1.33	DOX_DAR_3hr
15	1	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	1.95e-44	1.03e-45	1040	33.3	30000	21.9	1.52	DOX_DAR_3hr
16	1	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	5.2e-43	2.58e-44	964	30.8	27300	20	1.55	DOX_DAR_3hr
17	1	MA0155.1 (INSM1)	STREME-3	3-CCCTGCC	CCCTGCC	INSM1	1.08e-42	4.97e-44	1340	42.9	42100	30.7	1.4	DOX_DAR_3hr
18	3	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	1.13e-42	4.97e-44	1590	50.9	52400	38.3	1.33	DOX_DAR_3hr
19	1	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	4.01e-42	1.67e-43	779	24.9	20700	15.1	1.65	DOX_DAR_3hr
20	3	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	7.98e-42	3.16e-43	1110	35.5	33100	24.2	1.47	DOX_DAR_3hr
21	1	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	2.71e-41	1.02e-42	898	28.7	25100	18.4	1.57	DOX_DAR_3hr
22	4	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	6.02e-41	2.17e-42	1910	61	66400	48.5	1.26	DOX_DAR_3hr
23	1	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	1.75e-40	6.02e-42	996	31.9	28900	21.1	1.51	DOX_DAR_3hr
24	3	MA1578.1	VEZF1	MA1578.1	CCCCCCMYDH	VEZF1	2.72e-39	8.98e-41	2070	66.4	74300	54.3	1.22	DOX_DAR_3hr
25	5	MA1548.1 (PLAGL2)	STREME-1	1-GGSSCC	GGSSCC	PLAGL2	5.98e-35	1.89e-36	2300	73.4	85500	62.5	1.18	DOX_DAR_3hr
26	6	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	3.94e-34	1.2e-35	1910	61.2	68200	49.8	1.23	DOX_DAR_3hr
27	3	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	7.26e-32	2.13e-33	1780	56.9	62800	45.9	1.24	DOX_DAR_3hr
28	1	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	7.97e-32	2.26e-33	286	9.15	5560	4.06	2.26	DOX_DAR_3hr
29	7	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	5.35e-31	1.46e-32	1510	48.4	51600	37.7	1.29	DOX_DAR_3hr
30	3	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	8.35e-31	2.2e-32	1190	38	38100	27.9	1.36	DOX_DAR_3hr
31	8	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	7.65e-30	1.95e-31	1680	53.9	59100	43.2	1.25	DOX_DAR_3hr
32	9	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	4.18e-29	1.03e-30	1380	44.1	46300	33.8	1.3	DOX_DAR_3hr
33	3	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	1.77e-28	4.24e-30	2220	70.9	83300	60.8	1.17	DOX_DAR_3hr
34	3	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	1.05e-27	2.45e-29	2080	66.5	77100	56.3	1.18	DOX_DAR_3hr
35	10	MA0073.1 (RREB1)	STREME-8	8-CACCCCC	CACCCCC	RREB1	2.03e-27	4.59e-29	596	19.1	16300	11.9	1.61	DOX_DAR_3hr
36	11	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	8.96e-26	1.97e-27	2380	76	91500	66.9	1.14	DOX_DAR_3hr
37	12	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	1.33e-25	2.85e-27	1670	53.4	59400	43.4	1.23	DOX_DAR_3hr
38	13	MA0872.1	TFAP2A	MA0872.1	TGCCCYSRGGGCA	TFAP2A	1.2e-23	2.49e-25	941	30.1	29900	21.8	1.38	DOX_DAR_3hr
39	1	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	1.51e-22	3.07e-24	532	17	14700	10.8	1.58	DOX_DAR_3hr
40	14	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	2.39e-22	4.74e-24	1860	59.6	68800	50.2	1.19	DOX_DAR_3hr
41	3	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	3.6e-22	6.95e-24	1080	34.6	35700	26.1	1.32	DOX_DAR_3hr
42	3	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	4.53e-22	8.55e-24	601	19.2	17300	12.6	1.52	DOX_DAR_3hr
43	15	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	2.48e-21	4.57e-23	1370	43.9	48000	35	1.25	DOX_DAR_3hr
44	3	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	5.24e-21	9.43e-23	1780	57	65600	47.9	1.19	DOX_DAR_3hr
45	16	MA0146.2 (Zfx)	STREME-4	4-CAGGCC	CAGGCC	Zfx	7.44e-21	1.31e-22	1420	45.3	49900	36.4	1.24	DOX_DAR_3hr
46	1	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	2.5e-20	4.3e-22	973	31.1	31900	23.3	1.34	DOX_DAR_3hr
47	17	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	5.41e-20	9.12e-22	1750	55.9	64400	47.1	1.19	DOX_DAR_3hr
48	48	MA0528.2	ZNF263	MA0528.2	VNGGGGAGGASG	ZNF263	2.82e-19	4.66e-21	1350	43.1	47400	34.7	1.24	DOX_DAR_3hr
49	8	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	4.66e-19	7.53e-21	869	27.8	28100	20.5	1.36	DOX_DAR_3hr
50	3	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	1.1e-18	1.74e-20	1140	36.3	38800	28.4	1.28	DOX_DAR_3hr
51	1	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	1.33e-18	2.06e-20	205	6.56	4290	3.13	2.1	DOX_DAR_3hr
52	13	MA0813.1	TFAP2B	MA0813.1	TGCCCYBRGGGCA	TFAP2B	4.92e-18	7.49e-20	806	25.8	25900	18.9	1.37	DOX_DAR_3hr
53	18	MA1710.1	ZNF257	MA1710.1	VDGAGGCRAGRG	ZNF257	1.18e-17	1.76e-19	1880	60.2	71100	51.9	1.16	DOX_DAR_3hr
54	2	6-CCCAGC	STREME-6	6-CCCAGC	CCCAGC	CCCAGC	3.68e-17	5.39e-19	2770	88.7	113000	82.8	1.07	DOX_DAR_3hr
55	19	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	1.37e-16	1.97e-18	672	21.5	21000	15.4	1.4	DOX_DAR_3hr
56	20	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	1.47e-16	2.08e-18	2380	76.3	94400	69	1.11	DOX_DAR_3hr
57	3	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	1.91e-16	2.66e-18	668	21.4	20900	15.3	1.4	DOX_DAR_3hr
58	11	MA1987.1	ZNF701	MA1987.1	GAGCACYAARGGGGGRADDDD	ZNF701	2.6e-16	3.55e-18	2030	64.9	78000	57	1.14	DOX_DAR_3hr
59	3	MA0732.1	EGR3	MA0732.1	HHMCGCCCACGCAHH	EGR3	1.85e-15	2.48e-17	815	26.1	26800	19.6	1.33	DOX_DAR_3hr
60	12	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	2.22e-15	2.94e-17	1450	46.5	53100	38.8	1.2	DOX_DAR_3hr
61	21	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	7.76e-15	1.01e-16	2400	76.9	95800	70	1.1	DOX_DAR_3hr
62	12	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	1.35e-14	1.72e-16	1190	38.2	42400	31	1.23	DOX_DAR_3hr
63	13	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	1.97e-14	2.48e-16	2100	67.2	82000	59.9	1.12	DOX_DAR_3hr
64	22	MA0504.1	NR2C2	MA0504.1	VGRGGTCARAGGTCA	NR2C2	9.97e-14	1.22e-15	1850	59.2	70900	51.8	1.14	DOX_DAR_3hr
65	20	MA1569.1	TFAP2E	MA1569.1	YGCCYSRGGCD	TFAP2E	9.99e-14	1.22e-15	646	20.7	20700	15.1	1.37	DOX_DAR_3hr
66	20	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	1.4e-13	1.68e-15	2040	65.3	79500	58.1	1.12	DOX_DAR_3hr
67	13	MA0815.1	TFAP2C	MA0815.1	TGCCCYSRGGGCA	TFAP2C	4.7e-13	5.56e-15	722	23.1	23800	17.4	1.33	DOX_DAR_3hr
68	23	MA0694.1	ZBTB7B	MA0694.1	RCGACCACCGAA	ZBTB7B	6.04e-13	7.03e-15	819	26.2	27600	20.2	1.3	DOX_DAR_3hr
69	23	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	6.43e-13	7.39e-15	1760	56.1	67000	48.9	1.15	DOX_DAR_3hr
70	24	MA1528.1	NFIX	MA1528.1	STTGGCRNNGTGCCARB	NFIX	1.25e-12	1.42e-14	358	11.4	10200	7.42	1.55	DOX_DAR_3hr
71	11	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	2.17e-12	2.42e-14	2690	86.1	110000	80.7	1.07	DOX_DAR_3hr
72	13	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	4.06e-12	4.46e-14	2120	67.9	83700	61.2	1.11	DOX_DAR_3hr
73	25	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	1.33e-11	1.45e-13	1680	53.7	64100	46.8	1.15	DOX_DAR_3hr
74	23	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	2.48e-11	2.66e-13	1090	34.9	39200	28.6	1.22	DOX_DAR_3hr
75	13	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	3.32e-11	3.51e-13	2570	82.2	105000	76.7	1.07	DOX_DAR_3hr
76	26	MA0751.1	ZIC4	MA0751.1	GRCCCCCCGCKGYGH	ZIC4	3.52e-11	3.67e-13	2450	78.2	99000	72.3	1.08	DOX_DAR_3hr
77	27	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	7.53e-11	7.75e-13	2040	65.1	80200	58.6	1.11	DOX_DAR_3hr
78	12	MA1719.1	ZNF816	MA1719.1	DRRKGGGGACATGCHGGG	ZNF816	1.37e-10	1.39e-12	1780	57	69000	50.4	1.13	DOX_DAR_3hr
79	27	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	1.61e-09	1.62e-11	1420	45.3	53500	39.1	1.16	DOX_DAR_3hr
80	24	MA1643.1	NFIB	MA1643.1	NNCCTGGCAYNGTGCCAAGNN	NFIB	1.66e-09	1.64e-11	270	8.64	7570	5.53	1.57	DOX_DAR_3hr
81	28	MA0155.1	INSM1	MA0155.1	TGYCWGGGGGCR	INSM1	3.46e-09	3.39e-11	235	7.52	6390	4.67	1.62	DOX_DAR_3hr
82	20	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	3.81e-09	3.68e-11	2660	85.2	110000	80.5	1.06	DOX_DAR_3hr
83	27	MA1631.1	ASCL1	MA1631.1	NNGCACCTGCYNB	ASCL1	4.05e-09	3.87e-11	1340	42.7	50200	36.7	1.16	DOX_DAR_3hr
84	29	MA0130.1	ZNF354C	MA0130.1	MTCCAC	ZNF354C	1.77e-08	1.67e-10	2340	74.9	95100	69.5	1.08	DOX_DAR_3hr
85	30	9-GGCWGCC	STREME-9	9-GGCWGCC	GGCWGCC	GGCWGCC	2.54e-08	2.37e-10	648	20.7	22200	16.2	1.28	DOX_DAR_3hr
86	31	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	2.61e-08	2.4e-10	2820	90.2	118000	86.2	1.05	DOX_DAR_3hr
87	24	MA0739.1	Hic1	MA0739.1	RTGCCAACY	Hic1	2.84e-08	2.58e-10	1940	62.2	77100	56.4	1.1	DOX_DAR_3hr
88	11	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	8.4e-08	7.56e-10	2020	64.5	80600	58.9	1.1	DOX_DAR_3hr
89	24	MA1527.1	NFIC	MA1527.1	NTTGGCDNNRTGCCARN	NFIC	1.13e-07	1.01e-09	264	8.45	7680	5.61	1.51	DOX_DAR_3hr
90	32	MA1728.1	ZNF549	MA1728.1	NNTGCTGCCCWR	ZNF549	1.19e-07	1.05e-09	2950	94.2	125000	91.2	1.03	DOX_DAR_3hr
91	33	MA1982.1	ZNF574	MA1982.1	VGSCTAGAGMGGCCS	ZNF574	2.05e-07	1.79e-09	1980	63.2	78900	57.7	1.1	DOX_DAR_3hr
92	24	MA0119.1	NFIC::TLX1	MA0119.1	TGGCASSRWGCCAA	NFIC::TLX1	1.53e-06	1.32e-08	295	9.44	9050	6.61	1.43	DOX_DAR_3hr
93	8	MA0163.1	PLAG1	MA0163.1	GGGGCCCWAGGGGG	PLAG1	2.79e-06	2.38e-08	231	7.39	6760	4.94	1.5	DOX_DAR_3hr
94	34	MA1656.1	ZNF449	MA1656.1	NNAAGCCCAACCNN	ZNF449	3.04e-06	2.56e-08	679	21.7	24100	17.6	1.24	DOX_DAR_3hr
95	24	MA0738.1	HIC2	MA0738.1	RTGCCCRSB	HIC2	8.79e-06	7.33e-08	2150	68.9	87700	64.1	1.08	DOX_DAR_3hr
96	26	MA1629.1	Zic2	MA1629.1	NDCACAGCAGGDRG	Zic2	2.6e-05	2.15e-07	2360	75.6	97400	71.2	1.06	DOX_DAR_3hr
97	35	MA1121.1 (TEAD2)	MEME-5	ACATTCCW	ACATTCCW	TEAD2	7.54e-05	6.16e-07	491	15.7	17100	12.5	1.26	DOX_DAR_3hr
98	27	MA1652.1	ZKSCAN5	MA1652.1	NNRGGARGTGAGRR	ZKSCAN5	8.89e-05	7.18e-07	652	20.9	23500	17.2	1.21	DOX_DAR_3hr
99	27	MA0522.3	TCF3	MA0522.3	NVCACCTGCNN	TCF3	9.96e-05	7.97e-07	1160	37	44600	32.6	1.14	DOX_DAR_3hr
100	3	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	0.000118	9.34e-07	1060	33.9	40600	29.6	1.15	DOX_DAR_3hr
101	36	MA0767.1	GCM2	MA0767.1	BATGCGGGTR	GCM2	0.000123	9.64e-07	2880	92.1	122000	89.3	1.03	DOX_DAR_3hr
102	12	MA1727.1	ZNF417	MA1727.1	VRBVNTGGGCGCCAM	ZNF417	2e-04	1.55e-06	1360	43.6	53500	39.1	1.12	DOX_DAR_3hr
103	27	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	0.000288	2.22e-06	1860	59.7	75500	55.2	1.08	DOX_DAR_3hr
104	11	MA0597.2	THAP1	MA0597.2	VSGCAGGGCASV	THAP1	0.000418	3.18e-06	655	21	23900	17.5	1.2	DOX_DAR_3hr
105	37	MA1979.1	ZNF416	MA1979.1	TATCTGGGCAH	ZNF416	0.000491	3.7e-06	876	28	33100	24.2	1.16	DOX_DAR_3hr
106	38	MA1973.1	ZKSCAN3	MA1973.1	KDKCCCAGGCTAGCCCABNN	ZKSCAN3	0.000517	3.83e-06	1530	48.9	61000	44.6	1.1	DOX_DAR_3hr
107	36	MA0646.1	GCM1	MA0646.1	BATGCGGGTAC	GCM1	0.000517	3.83e-06	2400	76.9	1e+05	73	1.05	DOX_DAR_3hr
108	39	MA1628.1	Zic1::Zic2	MA1628.1	CVCAGCAGGNV	Zic1::Zic2	0.000537	3.94e-06	2550	81.5	107000	77.9	1.05	DOX_DAR_3hr
109	40	MA1637.1	EBF3	MA1637.1	NYCCCAAGGGANN	EBF3	0.000676	4.91e-06	1950	62.2	79300	58	1.07	DOX_DAR_3hr
110	41	MA0159.1	RARA::RXRA	MA0159.1	RGKTCANVGRSAGGTCA	RARA::RXRA	0.001	7.22e-06	1490	47.8	59600	43.5	1.1	DOX_DAR_3hr
111	27	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	0.00299	2.13e-05	1450	46.4	58000	42.3	1.1	DOX_DAR_3hr
112	42	MA1715.1	ZNF707	MA1715.1	CCCCACTCCTGGTAC	ZNF707	0.00355	2.51e-05	1150	36.7	44900	32.8	1.12	DOX_DAR_3hr
113	24	MA0671.1	NFIX	MA0671.1	NNTGCCAAN	NFIX	0.00388	2.72e-05	2580	82.4	108000	79.2	1.04	DOX_DAR_3hr
114	43	MA1985.1	ZNF669	MA1985.1	GGGGYGAYGACCRCT	ZNF669	0.00518	3.6e-05	1240	39.8	49200	35.9	1.11	DOX_DAR_3hr
115	27	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	0.00715	4.92e-05	1430	45.7	57300	41.8	1.09	DOX_DAR_3hr
116	44	MA1972.1	ZFP14	MA1972.1	GGAGGCHCHGGARBG	ZFP14	0.00725	4.95e-05	948	30.3	36700	26.8	1.13	DOX_DAR_3hr
117	45	MA1964.1	SMAD2	MA1964.1	NBCCAGACDN	SMAD2	0.0107	7.26e-05	614	19.6	22900	16.7	1.18	DOX_DAR_3hr
118	40	MA0154.4	EBF1	MA0154.4	NNTCCCCAGGGGANN	EBF1	0.0122	8.17e-05	2710	86.6	115000	83.9	1.03	DOX_DAR_3hr
119	21	MA0056.2	MZF1	MA0056.2	NNAATCCCCANNN	MZF1	0.0136	9.03e-05	3030	96.8	130000	95.3	1.02	DOX_DAR_3hr
120	27	MA1966.1	TFAP4::ETV1	MA1966.1	RSCGGAAGCAGSTGKN	TFAP4::ETV1	0.0169	0.000112	1890	60.5	77800	56.8	1.07	DOX_DAR_3hr
121	27	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	0.0177	0.000116	1520	48.5	61300	44.8	1.08	DOX_DAR_3hr
122	11	MA1567.2	Tbx6	MA1567.2	NRGGTGTGAANN	Tbx6	0.0237	0.000154	547	17.5	20300	14.8	1.18	DOX_DAR_3hr
123	40	MA1604.1	Ebf2	MA1604.1	NYCCCAAGGGANN	Ebf2	0.0252	0.000162	1980	63.4	82000	59.9	1.06	DOX_DAR_3hr
124	27	MA0649.1	HEY2	MA0649.1	GRCACGTGYC	HEY2	0.0306	0.000196	2100	67.2	87200	63.7	1.05	DOX_DAR_3hr
125	11	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	0.0365	0.000232	2110	67.6	87900	64.2	1.05	DOX_DAR_3hr
126	27	MA1635.1	BHLHE22	MA1635.1	NVCAGCTGBN	BHLHE22	0.0443	0.000279	1490	47.7	60500	44.2	1.08	DOX_DAR_3hr
127	46	MA0764.3	ETV4	MA0764.3	ACCGGAAGTR	ETV4	0.0451	0.000281	2440	78.1	103000	75	1.04	DOX_DAR_3hr
12	47	MA1979.1 (ZNF416)	STREME-7	7-AGAGCCCAG	AGAGCCCAG	ZNF416	0.103	0.00858	2820	90.2	122000	88.8	1.02	DOX_DAR_3hr
13	48	MA0528.2 (ZNF263)	STREME-10	10-ATCCTCTCCW	10-ATCCTCTCCW	ZNF263	6.64	0.511	625	20	27200	19.9	1.01	DOX_DAR_3hr
14	49	MA1107.2 (KLF9)	MEME-4	ACACACACACACACA	ACACACACACACACA	KLF9	10.2	0.729	7	0.22	348	0.25	1	DOX_DAR_3hr
15	50	MA1125.1 (ZNF384)	MEME-2	AAAAAAAAAAAAAAA	AAAAAAAAAAAAAAA	ZNF384	14.5	0.967	3	0.1	301	0.22	0.58	DOX_DAR_3hr

ER_rat <- 1.25
# mrc_type <- "EAR_open"
DOX_DAR_3hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  # geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_col(aes(x=log10Evalue))+
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DOX_DAR_3hr_combo response peaks(200bp) Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DOX_DAR_3hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  # geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*.5), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.5,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DOX DAR 3 hour response peaks(200bp) Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DOX_DAR_24hr data

DOX_DAR_24hr_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DOX_DAR_24hr_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DOX_DAR_24hr_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DOX_DAR_24hr_sea_all <- rbind(DOX_DAR_24hr_sea_disc, DOX_DAR_24hr_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DOX_DAR_24hr_combo <- DOX_DAR_24hr_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DOX_DAR_24hr_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="DOX_DAR_24hr")

DOX_DAR_24hr_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp DOX_DAR_24hr") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp DOX_DAR_24hr
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA1134.1 (FOS::JUNB)	STREME-1	1-RATGASTCATY	RATGASTCATY	FOS::JUNB	0	0	9050	15.5	5740	7.03	2.2	DOX_DAR_24hr
2	1	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	0	0	9320	16	6130	7.51	2.13	DOX_DAR_24hr
3	1	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	0	0	9050	15.5	5910	7.24	2.14	DOX_DAR_24hr
4	1	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	0	0	7540	12.9	4460	5.46	2.37	DOX_DAR_24hr
5	1	MA0478.1 (FOSL2)	MEME-2	MTGASTCAYCH	MTGASTCAYCH	FOSL2	0	0	10100	17.4	7040	8.62	2.01	DOX_DAR_24hr
6	1	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	0	0	8380	14.4	5290	6.47	2.22	DOX_DAR_24hr
7	1	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	0	0	9440	16.2	6370	7.8	2.08	DOX_DAR_24hr
8	1	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	0	0	7650	13.1	4600	5.64	2.33	DOX_DAR_24hr
9	1	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	0	0	7390	12.7	4360	5.34	2.37	DOX_DAR_24hr
10	1	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	0	0	8620	14.8	5570	6.82	2.17	DOX_DAR_24hr
11	1	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	0	0	8860	15.2	5850	7.16	2.12	DOX_DAR_24hr
12	1	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	0	0	10400	17.9	7480	9.16	1.95	DOX_DAR_24hr
13	1	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	0	0	7140	12.2	4190	5.14	2.38	DOX_DAR_24hr
14	1	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	0	0	7020	12	4100	5.03	2.39	DOX_DAR_24hr
15	1	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	0	0	6880	11.8	4040	4.95	2.38	DOX_DAR_24hr
16	1	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	0	0	9310	16	6480	7.93	2.01	DOX_DAR_24hr
17	1	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	0	0	6230	10.7	3510	4.3	2.48	DOX_DAR_24hr
18	1	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	0	0	10600	18.1	7880	9.65	1.88	DOX_DAR_24hr
19	1	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	0	0	6350	10.9	3630	4.44	2.45	DOX_DAR_24hr
20	1	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	0	0	6090	10.4	3410	4.18	2.5	DOX_DAR_24hr
21	1	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	0	0	6670	11.4	3970	4.86	2.35	DOX_DAR_24hr
22	1	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	0	0	5940	10.2	3340	4.09	2.49	DOX_DAR_24hr
23	1	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	0	0	7010	12	4400	5.38	2.23	DOX_DAR_24hr
24	1	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	0	0	10500	18	8060	9.87	1.82	DOX_DAR_24hr
25	1	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	0	0	6630	11.4	4090	5.01	2.27	DOX_DAR_24hr
26	1	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	0	0	10000	17.2	7570	9.27	1.85	DOX_DAR_24hr
27	1	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	0	0	5480	9.4	3060	3.74	2.51	DOX_DAR_24hr
28	1	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	0	0	10800	18.5	8560	10.5	1.77	DOX_DAR_24hr
29	1	MA0476.1 (FOS)	STREME-9	9-TCTGASTCA	TCTGASTCA	FOS	9.64e-253	1.63e-254	8480	14.5	7080	8.67	1.68	DOX_DAR_24hr
30	1	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	1.12e-181	1.82e-183	20400	34.9	22600	27.7	1.26	DOX_DAR_24hr
31	1	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	7.51e-178	1.19e-179	8390	14.4	7670	9.39	1.53	DOX_DAR_24hr
32	1	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	2.72e-145	4.15e-147	23200	39.8	27000	33.1	1.2	DOX_DAR_24hr
33	1	MA0150.2	Nfe2l2	MA0150.2	CASNATGACTCAGCA	Nfe2l2	5.56e-114	8.24e-116	15900	27.2	17800	21.8	1.24	DOX_DAR_24hr
34	2	MA1970.1 (TRPS1)	STREME-2	2-CTTATC	CTTATC	TRPS1	2.11e-96	3.03e-98	41900	71.7	54300	66.4	1.08	DOX_DAR_24hr
35	3	MA0726.1	VSX2	MA0726.1	CTAATTAN	VSX2	1.81e-85	2.53e-87	53200	91.1	71700	87.8	1.04	DOX_DAR_24hr
36	3	MA0720.1	Shox2	MA0720.1	YYAATTAR	Shox2	3.17e-85	4.31e-87	52300	89.6	70300	86.1	1.04	DOX_DAR_24hr
37	4	MA0676.1	Nr2e1	MA0676.1	AAAAGTCAA	Nr2e1	3.42e-85	4.52e-87	50200	86	67000	82.1	1.05	DOX_DAR_24hr
38	3	MA0725.1	VSX1	MA0725.1	YTAATTAN	VSX1	3.84e-82	4.94e-84	52300	89.7	70400	86.2	1.04	DOX_DAR_24hr
39	3	MA0718.1	RAX	MA0718.1	RYYAATTARH	RAX	8e-81	1e-82	50400	86.5	67500	82.7	1.05	DOX_DAR_24hr
40	3	MA0644.2	ESX1	MA0644.2	YYAATTAN	ESX1	3e-79	3.67e-81	47000	80.6	62300	76.3	1.06	DOX_DAR_24hr
41	3	MA0722.1	VAX1	MA0722.1	YTAATTAH	VAX1	2.59e-78	3.09e-80	51100	87.7	68600	84	1.04	DOX_DAR_24hr
42	3	MA0027.2	EN1	MA0027.2	SYAATTAV	EN1	2.45e-76	2.85e-78	51200	87.7	68700	84.2	1.04	DOX_DAR_24hr
43	3	MA0674.1	NKX6-1	MA0674.1	NTMATTAA	NKX6-1	4.36e-76	4.95e-78	51200	87.8	68800	84.3	1.04	DOX_DAR_24hr
44	3	MA0630.1	SHOX	MA0630.1	HTAATTRR	SHOX	2.51e-74	2.79e-76	54700	93.8	74400	91.1	1.03	DOX_DAR_24hr
45	1	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	7.14e-74	7.76e-76	2870	4.92	2440	2.99	1.65	DOX_DAR_24hr
46	3	MA0723.2	VAX2	MA0723.2	BYAATTAV	VAX2	1.97e-73	2.09e-75	53400	91.5	72300	88.5	1.03	DOX_DAR_24hr
47	3	MA0704.1	Lhx4	MA0704.1	YTAATTAR	Lhx4	1.09e-72	1.14e-74	54100	92.8	73500	90	1.03	DOX_DAR_24hr
48	3	MA0710.1	NOTO	MA0710.1	NYTAATTAVN	NOTO	2.92e-72	2.98e-74	48100	82.5	64200	78.6	1.05	DOX_DAR_24hr
49	3	MA0879.2	DLX1	MA0879.2	VYAATTAN	DLX1	8.12e-70	8.11e-72	54400	93.3	74000	90.6	1.03	DOX_DAR_24hr
50	5	MA1480.1	DPRX	MA1480.1	AGATAATCCN	DPRX	2.14e-69	2.1e-71	50600	86.7	67900	83.2	1.04	DOX_DAR_24hr
51	3	MA0882.1	DLX6	MA0882.1	VYAATTAN	DLX6	3.49e-69	3.35e-71	52600	90.2	71100	87.1	1.04	DOX_DAR_24hr
52	3	MA0721.1	UNCX	MA0721.1	YYAATTAV	UNCX	4.2e-69	3.95e-71	48900	83.9	65400	80.1	1.05	DOX_DAR_24hr
53	6	7-TMAGMT	STREME-7	7-TMAGMT	TMAGMT	TMAGMT	1.99e-68	1.83e-70	52900	90.6	71500	87.6	1.03	DOX_DAR_24hr
54	1	MA1640.1	MEIS2	MA1640.1	NNATGATTTATGDNH	MEIS2	7.37e-67	6.63e-69	48500	83.2	64900	79.4	1.05	DOX_DAR_24hr
55	1	MA1639.1	MEIS1	MA1639.1	NHCATMAATCAHN	MEIS1	7.45e-67	6.63e-69	31500	54	40200	49.2	1.1	DOX_DAR_24hr
56	3	MA0716.1	PRRX1	MA0716.1	YYAATTAR	PRRX1	1.34e-66	1.17e-68	55700	95.5	76200	93.3	1.02	DOX_DAR_24hr
57	5	MA0035.4	GATA1	MA0035.4	NHCTAATCTDH	GATA1	2.41e-66	2.07e-68	54000	92.6	73400	89.9	1.03	DOX_DAR_24hr
58	3	MA0793.1	POU6F2	MA0793.1	ASCTMATTAW	POU6F2	5.28e-65	4.46e-67	46900	80.4	62500	76.5	1.05	DOX_DAR_24hr
59	7	MA0635.1	BARHL2	MA0635.1	VHTAAAYGRT	BARHL2	1.53e-64	1.27e-66	52000	89.2	70300	86	1.04	DOX_DAR_24hr
60	3	MA0125.1	Nobox	MA0125.1	TAATTRSY	Nobox	2.23e-64	1.82e-66	48200	82.7	64500	79	1.05	DOX_DAR_24hr
61	3	MA1481.1	DRGX	MA1481.1	YYAATTAN	DRGX	5.95e-63	4.77e-65	47600	81.6	63600	77.9	1.05	DOX_DAR_24hr
62	3	MA0707.2	MNX1	MA0707.2	VYRATTAK	MNX1	6.1e-62	4.82e-64	35200	60.3	45500	55.8	1.08	DOX_DAR_24hr
63	3	MA0634.1	ALX3	MA0634.1	YYYAATTANV	ALX3	1.84e-61	1.43e-63	55500	95.1	75900	92.9	1.02	DOX_DAR_24hr
64	3	MA1476.2	Dlx5	MA1476.2	NDGCAATTAGNN	Dlx5	2.71e-61	2.07e-63	49700	85.2	66800	81.8	1.04	DOX_DAR_24hr
65	2	MA1104.2	GATA6	MA1104.2	HWWTCTTATCTNH	GATA6	3.95e-61	2.97e-63	52100	89.3	70500	86.3	1.03	DOX_DAR_24hr
66	8	MA0602.1	Arid5a	MA0602.1	SYAATATTGVDANH	Arid5a	1.16e-60	8.62e-63	48200	82.7	64600	79.1	1.05	DOX_DAR_24hr
67	3	MA0904.2	HOXB5	MA0904.2	STAATTAS	HOXB5	3.62e-60	2.65e-62	38200	65.4	49900	61.1	1.07	DOX_DAR_24hr
68	3	MA0717.1	RAX2	MA0717.1	YYAATTAV	RAX2	1.45e-59	1.05e-61	47800	82	64000	78.4	1.05	DOX_DAR_24hr
69	2	MA0036.3	GATA2	MA0036.3	NBCTTATCTNH	GATA2	2.73e-59	1.93e-61	43200	74	57100	70	1.06	DOX_DAR_24hr
70	3	MA0628.1	POU6F1	MA0628.1	AYTAATTART	POU6F1	5.19e-59	3.63e-61	44000	75.4	58400	71.5	1.06	DOX_DAR_24hr
71	5	MA0648.1	GSC	MA0648.1	VYTAATCCSY	GSC	2.66e-58	1.84e-60	48800	83.7	65500	80.2	1.04	DOX_DAR_24hr
72	9	MA0786.1	POU3F1	MA0786.1	WTATGCWAATKW	POU3F1	2.78e-58	1.89e-60	48900	83.8	65600	80.4	1.04	DOX_DAR_24hr
73	3	MA0880.1	Dlx3	MA0880.1	NYAATTAN	Dlx3	4.94e-58	3.31e-60	44800	76.8	59600	73	1.05	DOX_DAR_24hr
74	10	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	6.4e-58	4.23e-60	49000	83.9	65700	80.5	1.04	DOX_DAR_24hr
75	3	MA0876.1	BSX	MA0876.1	SYVATTAV	BSX	1.85e-57	1.21e-59	49000	84	65900	80.6	1.04	DOX_DAR_24hr
76	3	MA0881.1	Dlx4	MA0881.1	VYAATTAN	Dlx4	1.91e-57	1.23e-59	45100	77.3	60000	73.5	1.05	DOX_DAR_24hr
77	3	MA1495.1	HOXA1	MA1495.1	STAATTAS	HOXA1	2.6e-57	1.65e-59	29300	50.3	37500	45.9	1.1	DOX_DAR_24hr
78	3	MA1963.1	SATB1	MA1963.1	WWDCTAATAAHWW	SATB1	2.71e-56	1.7e-58	40700	69.7	53600	65.6	1.06	DOX_DAR_24hr
79	3	MA0885.2	Dlx2	MA0885.2	NDGCAATTAGNN	Dlx2	2.96e-56	1.83e-58	52600	90.2	71300	87.4	1.03	DOX_DAR_24hr
80	11	MA0899.1	HOXA10	MA0899.1	DGYMATAAAAH	HOXA10	3.09e-56	1.89e-58	51000	87.5	68900	84.4	1.04	DOX_DAR_24hr
81	9	MA0792.1	POU5F1B	MA0792.1	TATGCWAAT	POU5F1B	4.93e-56	2.97e-58	53100	90.9	72100	88.3	1.03	DOX_DAR_24hr
82	3	MA0680.2	Pax7	MA0680.2	DWTAATCAATTAWNH	Pax7	1.88e-55	1.12e-57	41200	70.7	54400	66.6	1.06	DOX_DAR_24hr
83	3	MA1549.1	POU6F1	MA1549.1	RTAATGAGVN	POU6F1	2.01e-55	1.19e-57	48000	82.3	64400	78.9	1.04	DOX_DAR_24hr
84	12	MA0084.1	SRY	MA0084.1	NWWAACAAT	SRY	2.42e-55	1.41e-57	50700	87	68500	83.9	1.04	DOX_DAR_24hr
85	13	3-ATTCAA	STREME-3	3-ATTCAA	ATTCAA	ATTCAA	4.18e-55	2.41e-57	51200	87.8	69200	84.8	1.04	DOX_DAR_24hr
86	1	MA1113.2	PBX2	MA1113.2	NHCATAAATCAHN	PBX2	1.74e-54	9.91e-57	35600	61	46400	56.8	1.07	DOX_DAR_24hr
87	3	MA0713.1	PHOX2A	MA0713.1	TAATYYAATTA	PHOX2A	2.91e-54	1.64e-56	41900	71.9	55500	67.9	1.06	DOX_DAR_24hr
88	3	MA0910.2	HOXD8	MA0910.2	GYMATTAM	HOXD8	3.5e-54	1.95e-56	34400	59	44700	54.8	1.08	DOX_DAR_24hr
89	3	MA1502.1	HOXB8	MA1502.1	GYMATTAM	HOXB8	3.83e-54	2.11e-56	34500	59.1	44700	54.8	1.08	DOX_DAR_24hr
90	3	MA0661.1	MEOX1	MA0661.1	VSTAATTAHC	MEOX1	4.87e-54	2.65e-56	45900	78.7	61300	75	1.05	DOX_DAR_24hr
91	14	MA0790.1	POU4F1	MA0790.1	ATGMATAATTAATG	POU4F1	6.37e-54	3.42e-56	43100	73.9	57200	70	1.06	DOX_DAR_24hr
92	15	MA0498.2 (MEIS1)	STREME-5	5-TTGWCAA	TTGWCAA	MEIS1	8.1e-54	4.31e-56	43600	74.8	58000	71	1.05	DOX_DAR_24hr
93	3	MA0890.1	GBX2	MA0890.1	RSYAATTARN	GBX2	1.41e-53	7.44e-56	44300	76	59000	72.2	1.05	DOX_DAR_24hr
94	3	MA0706.1	MEOX2	MA0706.1	DSTAATTAWN	MEOX2	1.44e-53	7.49e-56	46600	79.9	62400	76.4	1.05	DOX_DAR_24hr
95	3	MA0158.2	HOXA5	MA0158.2	GYMATTAS	HOXA5	1.52e-53	7.84e-56	26500	45.5	33700	41.2	1.1	DOX_DAR_24hr
96	16	MA0052.4	MEF2A	MA0052.4	DDCTAAAAATAGMHH	MEF2A	2.12e-53	1.08e-55	45500	77.9	60600	74.3	1.05	DOX_DAR_24hr
97	11	MA0465.2	CDX2	MA0465.2	NDGCAATAAAWN	CDX2	3.04e-52	1.53e-54	48600	83.3	65300	80	1.04	DOX_DAR_24hr
98	3	MA0068.2	PAX4	MA0068.2	CTAATTAG	PAX4	4.9e-52	2.45e-54	48500	83.1	65200	79.8	1.04	DOX_DAR_24hr
99	17	MA0495.3	MAFF	MA0495.3	DWGTCAGCATTTTWHN	MAFF	8.39e-51	4.15e-53	49600	85.1	66900	82	1.04	DOX_DAR_24hr
100	18	MA1589.1 (ZNF140)	STREME-8	8-ATTGCT	ATTGCT	ZNF140	1.33e-50	6.52e-53	52000	89.1	70600	86.4	1.03	DOX_DAR_24hr
101	3	MA0658.1	LHX6	MA0658.1	RCTAATTARY	LHX6	1.89e-50	9.16e-53	38300	65.6	50300	61.6	1.06	DOX_DAR_24hr
102	3	MA0666.2	MSX1	MA0666.2	SCAATTAR	MSX1	2.24e-50	1.07e-52	42500	72.9	56400	69.1	1.05	DOX_DAR_24hr
103	3	MA0903.1	HOXB3	MA0903.1	NNYMATTARN	HOXB3	2.26e-50	1.07e-52	44000	75.4	58600	71.8	1.05	DOX_DAR_24hr
104	3	MA1505.1	HOXC8	MA1505.1	KTAATTAM	HOXC8	2.69e-50	1.27e-52	45000	77.2	60100	73.6	1.05	DOX_DAR_24hr
105	11	MA0901.2	HOXB13	MA0901.2	WDCCAATAAAAWWW	HOXB13	7.59e-50	3.54e-52	44400	76.1	59200	72.5	1.05	DOX_DAR_24hr
106	19	MA1471.1	BARX2	MA1471.1	NWWAAYMATTAN	BARX2	9.88e-50	4.56e-52	47200	80.9	63400	77.6	1.04	DOX_DAR_24hr
107	5	MA0714.1	PITX3	MA0714.1	NYTAATCCC	PITX3	1.39e-49	6.35e-52	56600	96.9	77900	95.4	1.02	DOX_DAR_24hr
108	3	MA0675.1	NKX6-2	MA0675.1	NYMATTAA	NKX6-2	3.69e-49	1.67e-51	40400	69.3	53400	65.4	1.06	DOX_DAR_24hr
109	2	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	8.18e-49	3.67e-51	25600	43.9	32600	39.9	1.1	DOX_DAR_24hr
110	3	MA1519.1	LHX5	MA1519.1	STAATTAV	LHX5	1.15e-48	5.11e-51	26300	45.1	33500	41.1	1.1	DOX_DAR_24hr
111	9	MA0785.1	POU2F1	MA0785.1	AWTATGCWAATK	POU2F1	1.65e-48	7.25e-51	48400	83	65200	79.8	1.04	DOX_DAR_24hr
112	10	MA0032.2	FOXC1	MA0032.2	WAWGTAAAYAW	FOXC1	4.02e-48	1.76e-50	48500	83.2	65400	80	1.04	DOX_DAR_24hr
113	5	MA0712.2	OTX2	MA0712.2	NDRGGATTARNN	OTX2	1.45e-47	6.26e-50	53600	91.9	73100	89.5	1.03	DOX_DAR_24hr
114	5	MA0891.1	GSC2	MA0891.1	NYTAATCCBH	GSC2	1.53e-47	6.55e-50	54100	92.8	73900	90.5	1.02	DOX_DAR_24hr
115	3	MA0654.1	ISX	MA0654.1	YYAATTAR	ISX	1.89e-47	8.01e-50	37200	63.8	48900	59.9	1.07	DOX_DAR_24hr
116	3	MA0888.1	EVX2	MA0888.1	VVTAATTAVB	EVX2	1.9e-47	8.01e-50	47700	81.8	64200	78.6	1.04	DOX_DAR_24hr
117	3	MA0708.2	MSX2	MA0708.2	SCAATTAV	MSX2	2.12e-47	8.87e-50	41100	70.4	54400	66.6	1.06	DOX_DAR_24hr
118	10	MA0041.2	FOXD3	MA0041.2	WAWGHAAATAAACARY	FOXD3	1.7e-46	7.06e-49	49400	84.6	66700	81.6	1.04	DOX_DAR_24hr
119	3	MA0788.1	POU3F3	MA0788.1	WWTATGCWAATTW	POU3F3	2.17e-46	8.91e-49	44700	76.6	59800	73.2	1.05	DOX_DAR_24hr
120	3	MA0902.2	HOXB2	MA0902.2	SYAATTAS	HOXB2	2.39e-46	9.72e-49	26800	45.9	34300	42	1.09	DOX_DAR_24hr
121	5	MA0711.1	OTX1	MA0711.1	HTAATCCS	OTX1	2.66e-46	1.08e-48	49200	84.3	66400	81.3	1.04	DOX_DAR_24hr
122	11	MA0650.3	Hoxa13	MA0650.3	NNCCAATAAAAN	Hoxa13	2.93e-46	1.18e-48	48300	82.7	65000	79.6	1.04	DOX_DAR_24hr
123	9	MA0142.1	Pou5f1::Sox2	MA0142.1	CWTTGTYATGCAAAT	Pou5f1::Sox2	3.21e-46	1.28e-48	46800	80.3	62900	77	1.04	DOX_DAR_24hr
124	3	MA0912.2	HOXD3	MA0912.2	CTAATTAC	HOXD3	1.68e-45	6.62e-48	23600	40.4	29800	36.5	1.11	DOX_DAR_24hr
125	14	MA0791.1	POU4F3	MA0791.1	RTGMATWATTAATGAR	POU4F3	3.19e-45	1.25e-47	38800	66.5	51200	62.8	1.06	DOX_DAR_24hr
126	3	MA0709.1	Msx3	MA0709.1	SCAATTAN	Msx3	4.1e-45	1.59e-47	38700	66.4	51200	62.6	1.06	DOX_DAR_24hr
127	10	MA0031.1	FOXD1	MA0031.1	GTAAACAW	FOXD1	2.15e-44	8.29e-47	41800	71.7	55700	68.2	1.05	DOX_DAR_24hr
128	3	MA0662.1	MIXL1	MA0662.1	NBYAATTAVN	MIXL1	3.85e-44	1.47e-46	42900	73.5	57200	70	1.05	DOX_DAR_24hr
129	12	MA1152.1	SOX15	MA1152.1	CYWTTGTTHW	SOX15	6.06e-44	2.3e-46	51700	88.6	70300	86.1	1.03	DOX_DAR_24hr
130	3	MA0705.1	Lhx8	MA0705.1	CTAATTAV	Lhx8	7.01e-44	2.64e-46	31500	54	40900	50.1	1.08	DOX_DAR_24hr
131	3	MA1498.2	HOXA7	MA1498.2	SYMATTAV	HOXA7	1.76e-43	6.56e-46	54700	93.7	74900	91.7	1.02	DOX_DAR_24hr
132	3	MA0612.2	EMX1	MA0612.2	BTAATTAS	EMX1	1.84e-43	6.8e-46	22800	39	28800	35.3	1.11	DOX_DAR_24hr
133	3	MA0701.2	LHX9	MA0701.2	CYAATTAR	LHX9	3.67e-43	1.35e-45	28700	49.1	37000	45.3	1.08	DOX_DAR_24hr
134	7	MA1608.1	Isl1	MA1608.1	NNCCATTAGNN	Isl1	1.83e-42	6.69e-45	52800	90.5	71900	88.1	1.03	DOX_DAR_24hr
135	3	MA0699.1	LBX2	MA0699.1	NCYAATTARN	LBX2	1.94e-42	7.05e-45	48300	82.9	65200	79.9	1.04	DOX_DAR_24hr
136	3	MA0642.2	EN2	MA0642.2	VSYAATTA	EN2	4e-42	1.44e-44	47300	81	63600	77.9	1.04	DOX_DAR_24hr
137	2	MA0037.4	Gata3	MA0037.4	NHTCTTATCTNH	Gata3	4.35e-42	1.55e-44	54500	93.5	74700	91.5	1.02	DOX_DAR_24hr
138	10	MA0148.4	FOXA1	MA0148.4	WWGTAAACATNN	FOXA1	8.65e-42	3.07e-44	53600	91.9	73200	89.7	1.02	DOX_DAR_24hr
139	7	MA1978.1	ZNF354A	MA1978.1	HWAADWATAAATGRAYWAWTT	ZNF354A	9.29e-42	3.27e-44	48700	83.5	65800	80.6	1.04	DOX_DAR_24hr
140	2	MA1970.1	TRPS1	MA1970.1	NHTCTTATCTNH	TRPS1	9.62e-42	3.36e-44	34500	59.2	45300	55.4	1.07	DOX_DAR_24hr
141	3	MA0886.1	EMX2	MA0886.1	VBTAATTARB	EMX2	2.9e-41	1.01e-43	28700	49.2	37100	45.4	1.08	DOX_DAR_24hr
142	3	MA0601.1	Arid3b	MA0601.1	ATATTAATWAN	Arid3b	4.24e-41	1.46e-43	38000	65.2	50300	61.6	1.06	DOX_DAR_24hr
143	10	MA1607.1	Foxl2	MA1607.1	DDWATGTAAACANN	Foxl2	1.13e-40	3.87e-43	52600	90.1	71700	87.8	1.03	DOX_DAR_24hr
144	3	MA0875.1	BARX1	MA0875.1	VCMATTAV	BARX1	4.76e-40	1.62e-42	45000	77.2	60400	74	1.04	DOX_DAR_24hr
145	9	MA1115.1	POU5F1	MA1115.1	WHATGCAAATN	POU5F1	4.87e-40	1.64e-42	52200	89.4	71100	87	1.03	DOX_DAR_24hr
146	11	MA0909.3	Hoxd13	MA0909.3	NNCAATAAAW	Hoxd13	6.53e-40	2.19e-42	37700	64.7	49900	61.1	1.06	DOX_DAR_24hr
147	10	MA0047.3	FOXA2	MA0047.3	RWGTAAACANN	FOXA2	7.21e-40	2.4e-42	53700	92	73400	89.9	1.02	DOX_DAR_24hr
148	10	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	1.23e-39	4.08e-42	52100	89.2	70900	86.8	1.03	DOX_DAR_24hr
149	2	MA0482.2	GATA4	MA0482.2	NNCCTTATCTNH	GATA4	3.07e-39	1.01e-41	53700	92	73400	89.9	1.02	DOX_DAR_24hr
150	3	MA0892.1	GSX1	MA0892.1	NCYMATTAVN	GSX1	8.67e-39	2.83e-41	46600	79.9	62800	76.9	1.04	DOX_DAR_24hr
151	1	MA0591.1	Bach1::Mafk	MA0591.1	RSSATGACTCAGCAB	Bach1::Mafk	1.1e-38	3.58e-41	5960	10.2	6630	8.12	1.26	DOX_DAR_24hr
152	19	MA1530.1	NKX6-3	MA1530.1	VYCATTAWW	NKX6-3	1.2e-38	3.85e-41	26700	45.7	34400	42.1	1.09	DOX_DAR_24hr
153	20	MA0679.2	ONECUT1	MA0679.2	WAAAAATCAATAAWWN	ONECUT1	1.6e-38	5.1e-41	36200	62.1	47800	58.6	1.06	DOX_DAR_24hr
154	21	MA0025.2	NFIL3	MA0025.2	NRTTATGYAATNN	NFIL3	2.23e-38	7.09e-41	47300	81.1	63900	78.2	1.04	DOX_DAR_24hr
155	12	MA0143.4	SOX2	MA0143.4	DNACAATGGNN	SOX2	3.02e-38	9.53e-41	50400	86.4	68400	83.8	1.03	DOX_DAR_24hr
156	9	MA0627.2	POU2F3	MA0627.2	NWTATGCAAATNH	POU2F3	3.36e-38	1.06e-40	45200	77.4	60700	74.3	1.04	DOX_DAR_24hr
157	12	MA0868.2	SOX8	MA0868.2	MGAACAATRG	SOX8	3.46e-38	1.08e-40	51300	87.9	69800	85.5	1.03	DOX_DAR_24hr
158	3	MA1497.1	HOXA6	MA1497.1	BGYMATTANN	HOXA6	2.7e-37	8.36e-40	48400	82.9	65400	80.1	1.03	DOX_DAR_24hr
159	10	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	3.83e-37	1.18e-39	47700	81.8	64500	79	1.04	DOX_DAR_24hr
160	3	MA0895.1	HMBOX1	MA0895.1	MYTAGTTAMS	HMBOX1	7.43e-37	2.27e-39	47000	80.6	63500	77.7	1.04	DOX_DAR_24hr
161	22	MA1143.1	FOSL1::JUND	MA1143.1	RTGACGTMAY	FOSL1::JUND	1.69e-36	5.14e-39	21500	36.9	27400	33.5	1.1	DOX_DAR_24hr
162	23	MA1657.1	ZNF652	MA1657.1	BAAAGRGTTAAN	ZNF652	2.38e-36	7.17e-39	45100	77.4	60700	74.4	1.04	DOX_DAR_24hr
163	24	MA0122.3	Nkx3-2	MA0122.3	WWAAMCACTTAAN	Nkx3-2	9.37e-36	2.81e-38	47100	80.7	63600	77.9	1.04	DOX_DAR_24hr
164	17	MA0117.2	Mafb	MA0117.2	AWWNTGCTGACD	Mafb	1.34e-35	4e-38	42500	72.9	56900	69.7	1.05	DOX_DAR_24hr
165	9	MA0789.1	POU3F4	MA0789.1	TATGCWAAT	POU3F4	1.4e-35	4.15e-38	41000	70.3	54800	67.1	1.05	DOX_DAR_24hr
166	3	MA0153.2	HNF1B	MA0153.2	GTTAATNATTAAY	HNF1B	1.78e-35	5.24e-38	26000	44.6	33600	41.1	1.08	DOX_DAR_24hr
167	3	MA1500.1	HOXB6	MA1500.1	BTAATKRC	HOXB6	2.06e-35	6.04e-38	41100	70.4	54900	67.2	1.05	DOX_DAR_24hr
168	11	MA0905.1	HOXC10	MA0905.1	GTCRTAAAAH	HOXC10	2.37e-35	6.89e-38	42900	73.5	57500	70.4	1.04	DOX_DAR_24hr
169	25	MA0769.2	TCF7	MA0769.2	NNCTTTGAWVT	TCF7	3.3e-34	9.55e-37	52200	89.4	71200	87.2	1.03	DOX_DAR_24hr
170	22	MA0018.4	CREB1	MA0018.4	NNRTGATGTCAYN	CREB1	3.94e-34	1.14e-36	52400	89.8	71600	87.7	1.02	DOX_DAR_24hr
171	10	MA1103.2	FOXK2	MA1103.2	DDGTAAACANN	FOXK2	4.01e-34	1.15e-36	55300	94.8	76100	93.2	1.02	DOX_DAR_24hr
172	3	MA1518.2	Lhx1	MA1518.2	NNNTGCTAATTAGCANNN	Lhx1	5.09e-34	1.45e-36	41400	71	55400	67.8	1.05	DOX_DAR_24hr
173	3	MA0787.1	POU3F2	MA0787.1	WTATGCWAATKA	POU3F2	5.87e-34	1.66e-36	40700	69.7	54300	66.5	1.05	DOX_DAR_24hr
174	10	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	5.89e-34	1.66e-36	49700	85.2	67500	82.6	1.03	DOX_DAR_24hr
175	21	MA0102.4	CEBPA	MA0102.4	NDATTGCACAATHN	CEBPA	6.06e-34	1.69e-36	48700	83.6	66100	80.9	1.03	DOX_DAR_24hr
176	3	MA0893.2	GSX2	MA0893.2	SYMATTAR	GSX2	6.47e-34	1.8e-36	54200	93	74400	91.1	1.02	DOX_DAR_24hr
177	14	MA0046.2	HNF1A	MA0046.2	DRTTAATNATTAACN	HNF1A	6.67e-34	1.84e-36	26900	46.2	34900	42.8	1.08	DOX_DAR_24hr
178	3	MA0889.1	GBX1	MA0889.1	VCYAATTASY	GBX1	1.28e-33	3.52e-36	36100	61.9	47800	58.5	1.06	DOX_DAR_24hr
179	3	MA0724.1	VENTX	MA0724.1	AMCGATTAR	VENTX	1.38e-33	3.77e-36	35000	60.1	46300	56.7	1.06	DOX_DAR_24hr
180	10	MA0481.3	FOXP1	MA0481.3	NDGTAAACANH	FOXP1	1.73e-33	4.7e-36	50600	86.8	68900	84.4	1.03	DOX_DAR_24hr
181	5	MA0682.2	PITX1	MA0682.2	YTAATCCH	PITX1	3.02e-33	8.15e-36	33000	56.6	43400	53.2	1.06	DOX_DAR_24hr
182	10	MA0042.2	FOXI1	MA0042.2	GTAAACA	FOXI1	8.25e-32	2.22e-34	45800	78.5	61800	75.7	1.04	DOX_DAR_24hr
183	10	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	9.62e-32	2.57e-34	48700	83.4	66000	80.9	1.03	DOX_DAR_24hr
184	26	MA0108.2	TBP	MA0108.2	STATAAAWRSVVVBN	TBP	1.2e-31	3.19e-34	45600	78.2	61600	75.4	1.04	DOX_DAR_24hr
185	10	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	1.24e-31	3.28e-34	50500	86.5	68700	84.1	1.03	DOX_DAR_24hr
186	3	MA1501.1	HOXB7	MA1501.1	GGTAATTAVS	HOXB7	2.04e-31	5.36e-34	43600	74.7	58600	71.8	1.04	DOX_DAR_24hr
187	2	MA0140.2	GATA1::TAL1	MA0140.2	MTTATCWSNNNNNHVCAG	GATA1::TAL1	2.91e-31	7.6e-34	20600	35.2	26200	32.1	1.1	DOX_DAR_24hr
188	3	MA0900.2	HOXA2	MA0900.2	STAATTAS	HOXA2	3.56e-31	9.25e-34	19900	34.1	25400	31.1	1.1	DOX_DAR_24hr
189	3	MA1463.1	ARGFX	MA1463.1	DCTAATTARM	ARGFX	2.3e-30	5.96e-33	27300	46.7	35500	43.5	1.07	DOX_DAR_24hr
190	25	MA0523.1	TCF7L2	MA0523.1	DRASATCAAAGRVA	TCF7L2	3.31e-30	8.53e-33	39100	67.1	52300	64	1.05	DOX_DAR_24hr
191	3	MA0887.1	EVX1	MA0887.1	VVTAATTABS	EVX1	6.79e-30	1.74e-32	55900	95.9	77200	94.5	1.01	DOX_DAR_24hr
192	12	MA1563.2	SOX18	MA1563.2	AACAATDV	SOX18	1.02e-29	2.61e-32	43700	74.9	58900	72.1	1.04	DOX_DAR_24hr
193	3	MA0132.2	PDX1	MA0132.2	VYAATTAR	PDX1	1.65e-29	4.17e-32	30200	51.8	39700	48.6	1.07	DOX_DAR_24hr
194	27	MA0809.2	TEAD4	MA0809.2	NNACATTCCARN	TEAD4	7.01e-29	1.77e-31	46800	80.3	63400	77.7	1.03	DOX_DAR_24hr
195	21	MA1636.1	CEBPG	MA1636.1	NDATGATGCAATMHH	CEBPG	7.3e-29	1.83e-31	42700	73.1	57400	70.3	1.04	DOX_DAR_24hr
196	3	MA0700.2	LHX2	MA0700.2	DDCCAATTADN	LHX2	9.09e-29	2.27e-31	32400	55.5	42800	52.4	1.06	DOX_DAR_24hr
197	11	MA0898.1	Hmx3	MA0898.1	ASAAGCAATTAAWRRAT	Hmx3	1.41e-28	3.49e-31	37500	64.2	50000	61.2	1.05	DOX_DAR_24hr
198	24	MA0124.2	Nkx3-1	MA0124.2	RCCACTTAA	Nkx3-1	1.84e-28	4.54e-31	46700	80.1	63300	77.5	1.03	DOX_DAR_24hr
199	24	MA0896.1	Hmx1	MA0896.1	VSVAGCAATTAAWGVDB	Hmx1	2.72e-28	6.68e-31	35400	60.6	47000	57.6	1.05	DOX_DAR_24hr
200	3	MA1499.1	HOXB4	MA1499.1	RTMATTAR	HOXB4	2.79e-28	6.83e-31	32400	55.5	42700	52.3	1.06	DOX_DAR_24hr
201	28	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	5.52e-28	1.34e-30	49700	85.3	67800	83	1.03	DOX_DAR_24hr
202	5	MA0467.2	Crx	MA0467.2	NDGGATTANN	Crx	5.59e-28	1.35e-30	44500	76.2	60100	73.5	1.04	DOX_DAR_24hr
203	12	MA1120.1	SOX13	MA1120.1	DVACAATGGNN	SOX13	9.57e-28	2.3e-30	50200	86	68400	83.8	1.03	DOX_DAR_24hr
204	3	MA0075.3	PRRX2	MA0075.3	CTAATTAN	PRRX2	9.6e-28	2.3e-30	26300	45.1	34300	42	1.07	DOX_DAR_24hr
205	24	MA0914.1	ISL2	MA0914.1	GCAMTTAR	ISL2	1.25e-27	2.98e-30	53700	92	73700	90.2	1.02	DOX_DAR_24hr
206	3	MA0853.1	Alx4	MA0853.1	CGCRYTAATTARYHNNY	Alx4	2.04e-27	4.86e-30	28000	48	36700	45	1.07	DOX_DAR_24hr
207	1	MA0070.1	PBX1	MA0070.1	HCATCAATCAAW	PBX1	3.33e-27	7.87e-30	25600	44	33400	40.9	1.07	DOX_DAR_24hr
208	3	MA1504.1	HOXC4	MA1504.1	VTMATTAN	HOXC4	1.05e-26	2.47e-29	38700	66.3	51800	63.4	1.05	DOX_DAR_24hr
209	12	MA0077.1	SOX9	MA0077.1	CYATTGTTY	SOX9	3.98e-26	9.32e-29	30400	52.1	40100	49.1	1.06	DOX_DAR_24hr
210	12	MA0514.2	Sox3	MA0514.2	DNACAATGGNN	Sox3	6.08e-26	1.42e-28	50100	85.8	68300	83.7	1.03	DOX_DAR_24hr
211	3	MA0894.1	HESX1	MA0894.1	GHTAATTRRH	HESX1	1.19e-25	2.75e-28	29500	50.5	38800	47.5	1.06	DOX_DAR_24hr
212	20	MA0755.1	CUX2	MA0755.1	TRATCGATAW	CUX2	4.54e-25	1.05e-27	34100	58.5	45400	55.6	1.05	DOX_DAR_24hr
213	29	4-TAAAGA	STREME-4	4-TAAAGA	TAAAGA	TAAAGA	5.72e-25	1.31e-27	56700	97.3	78600	96.2	1.01	DOX_DAR_24hr
214	30	MA1489.1	FOXN3	MA1489.1	GTAAACAA	FOXN3	1.35e-24	3.08e-27	43500	74.5	58800	72	1.04	DOX_DAR_24hr
215	11	MA0151.1	Arid3a	MA0151.1	ATYAAA	Arid3a	1.86e-24	4.23e-27	29300	50.2	38600	47.2	1.06	DOX_DAR_24hr
216	10	MA0157.3	Foxo3	MA0157.3	NDGTAAACARNN	Foxo3	1.87e-24	4.23e-27	54300	93	74700	91.5	1.02	DOX_DAR_24hr
217	31	MA0606.2	Nfat5	MA0606.2	NNATGGAAAAWN	Nfat5	1.98e-24	4.47e-27	55200	94.6	76100	93.2	1.02	DOX_DAR_24hr
218	12	MA1562.1	SOX14	MA1562.1	CCGAACAATG	SOX14	2.38e-24	5.33e-27	42000	72	56600	69.4	1.04	DOX_DAR_24hr
219	32	MA1118.1	SIX1	MA1118.1	GWAACCTGAKM	SIX1	4.42e-24	9.87e-27	54100	92.8	74500	91.2	1.02	DOX_DAR_24hr
220	33	MA1124.1	ZNF24	MA1124.1	CATTCATTCATTC	ZNF24	4.9e-24	1.09e-26	29500	50.6	39000	47.7	1.06	DOX_DAR_24hr
221	7	MA0877.3	BARHL1	MA0877.3	AMCGTTTA	BARHL1	2.15e-23	4.77e-26	49200	84.3	67100	82.2	1.03	DOX_DAR_24hr
222	10	MA0850.1	FOXP3	MA0850.1	RTAAACA	FOXP3	2.6e-23	5.72e-26	51500	88.2	70500	86.3	1.02	DOX_DAR_24hr
223	34	MA1603.1	Dmrt1	MA1603.1	GHTACAAAGTADC	Dmrt1	3.03e-23	6.66e-26	46400	79.6	63100	77.2	1.03	DOX_DAR_24hr
224	12	MA0867.2	SOX4	MA0867.2	RAACAAAGRV	SOX4	1.31e-22	2.87e-25	48500	83.1	66100	80.9	1.03	DOX_DAR_24hr
225	3	MA0618.1	LBX1	MA0618.1	TTAATTAG	LBX1	5.91e-22	1.28e-24	34900	59.8	46600	57.1	1.05	DOX_DAR_24hr
226	25	MA1991.1	Hnf1A	MA1991.1	NBCCTTTGATSTBN	Hnf1A	7.3e-22	1.58e-24	56800	97.3	78700	96.3	1.01	DOX_DAR_24hr
227	3	MA0681.2	PHOX2B	MA0681.2	WWTAATCAAATTAWWW	PHOX2B	4.4e-21	9.49e-24	27200	46.6	35900	43.9	1.06	DOX_DAR_24hr
228	28	MA0774.1	MEIS2	MA0774.1	TTGACAGS	MEIS2	7.91e-21	1.7e-23	24700	42.4	32400	39.7	1.07	DOX_DAR_24hr
229	16	MA0497.1	MEF2C	MA0497.1	DDDCYAAAAATAGMW	MEF2C	1.45e-20	3.1e-23	31500	54	41900	51.4	1.05	DOX_DAR_24hr
230	35	MA0095.3	Yy1	MA0095.3	NNCAAAATGGCN	Yy1	2.11e-20	4.5e-23	55900	95.8	77300	94.7	1.01	DOX_DAR_24hr
231	36	MA0596.1	SREBF2	MA0596.1	RTGGGGTGAY	SREBF2	2.96e-20	6.27e-23	12400	21.2	15600	19.1	1.11	DOX_DAR_24hr
232	11	MA0911.1	Hoxa11	MA0911.1	RGTCGTAAAANT	Hoxa11	3.03e-20	6.4e-23	43700	74.8	59200	72.5	1.03	DOX_DAR_24hr
233	11	MA0878.3	CDX1	MA0878.3	GGYMATAAAA	CDX1	4.51e-20	9.46e-23	25900	44.3	34100	41.7	1.06	DOX_DAR_24hr
234	37	MA1588.1	ZNF136	MA1588.1	RWATTCTTGGTTGRC	ZNF136	7.39e-20	1.54e-22	31000	53.1	41200	50.5	1.05	DOX_DAR_24hr
235	10	MA0852.2	FOXK1	MA0852.2	NRDGTAAACAAGNN	FOXK1	8.2e-20	1.71e-22	53500	91.7	73700	90.2	1.02	DOX_DAR_24hr
236	27	MA0808.1	TEAD3	MA0808.1	RCATTCCW	TEAD3	8.23e-20	1.71e-22	32600	55.9	43500	53.3	1.05	DOX_DAR_24hr
237	12	MA0442.2	SOX10	MA0442.2	NDAACAAAGVN	SOX10	1.22e-19	2.52e-22	53900	92.4	74300	90.9	1.02	DOX_DAR_24hr
238	38	MA1114.1 (PBX3)	STREME-6	6-AGTGACA	AGTGACA	PBX3	2.11e-19	4.34e-22	28600	49	37900	46.4	1.06	DOX_DAR_24hr
239	20	MA0754.2	CUX1	MA0754.2	TAATCGATAM	CUX1	2.59e-19	5.3e-22	37500	64.3	50400	61.7	1.04	DOX_DAR_24hr
240	5	MA0883.1	Dmbx1	MA0883.1	WDRWNMGGATTADKNNW	Dmbx1	2.82e-19	5.75e-22	30500	52.2	40500	49.6	1.05	DOX_DAR_24hr
241	38	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	3.02e-19	6.13e-22	16200	27.8	20800	25.5	1.09	DOX_DAR_24hr
242	39	MA0106.3	TP53	MA0106.3	RACATGYCCGGRCATGTY	TP53	5.74e-19	1.16e-21	308	0.53	179	0.22	2.4	DOX_DAR_24hr
243	3	MA1577.1	TLX2	MA1577.1	BYAATTAR	TLX2	6.55e-19	1.32e-21	21800	37.4	28500	34.9	1.07	DOX_DAR_24hr
244	40	MA0092.1	Hand1::Tcf3	MA0092.1	BRTCTGGMWT	Hand1::Tcf3	7.48e-19	1.5e-21	53800	92.3	74200	90.8	1.02	DOX_DAR_24hr
245	27	MA0090.3	TEAD1	MA0090.3	NNACATTCCAGSN	TEAD1	9.12e-19	1.82e-21	51200	87.7	70200	86	1.02	DOX_DAR_24hr
246	21	MA0836.2	CEBPD	MA0836.2	NRTTGCACAAYHN	CEBPD	1.51e-18	3.01e-21	43500	74.6	59100	72.4	1.03	DOX_DAR_24hr
247	28	MA0775.1	MEIS3	MA0775.1	DTGACAGS	MEIS3	2.69e-18	5.33e-21	10000	17.2	12500	15.3	1.12	DOX_DAR_24hr
248	32	MA1119.1	SIX2	MA1119.1	NNCTGAAACCTGATMY	SIX2	3.04e-18	6e-21	50900	87.2	69800	85.4	1.02	DOX_DAR_24hr
249	11	MA0897.1	Hmx2	MA0897.1	ASAAGCAATTAAHVVRT	Hmx2	3.93e-18	7.72e-21	32200	55.1	43000	52.6	1.05	DOX_DAR_24hr
250	31	MA0625.2	NFATC3	MA0625.2	RYGGAAAMH	NFATC3	5.27e-18	1.03e-20	58000	99.4	80800	99	1	DOX_DAR_24hr
251	11	MA0913.2	HOXD9	MA0913.2	GYMATAAAAH	HOXD9	9.56e-18	1.86e-20	33500	57.4	44800	54.9	1.05	DOX_DAR_24hr
252	41	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	1.47e-17	2.85e-20	50900	87.3	69900	85.6	1.02	DOX_DAR_24hr
253	21	MA0043.3	HLF	MA0043.3	NNRTTATGCAACHN	HLF	8.83e-17	1.71e-19	34400	59	46200	56.6	1.04	DOX_DAR_24hr
254	10	MA0480.2	Foxo1	MA0480.2	NDGTAAACANN	Foxo1	1.6e-16	3.07e-19	56200	96.3	77900	95.3	1.01	DOX_DAR_24hr
255	24	MA0672.1	NKX2-3	MA0672.1	VCCACTTRAV	NKX2-3	2.49e-16	4.77e-19	15400	26.3	19800	24.2	1.09	DOX_DAR_24hr
256	42	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	3.89e-16	7.43e-19	28300	48.6	37700	46.2	1.05	DOX_DAR_24hr
257	43	MA0611.2	Dux	MA0611.2	NTGATTBAATCAVWNN	Dux	8.64e-16	1.65e-18	8840	15.2	11000	13.5	1.12	DOX_DAR_24hr
258	44	MA1105.2	GRHL2	MA1105.2	NRAACAGGTTYN	GRHL2	1.61e-15	3.05e-18	56700	97.1	78600	96.3	1.01	DOX_DAR_24hr
259	45	MA1623.1	Stat2	MA1623.1	RGAAACAGAAASH	Stat2	1.94e-15	3.67e-18	47700	81.8	65300	80	1.02	DOX_DAR_24hr
260	41	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	1.06e-14	2e-17	45000	77.1	61400	75.2	1.03	DOX_DAR_24hr
261	46	MA1112.2	NR4A1	MA1112.2	NNAAAGGTCANN	NR4A1	1.19e-14	2.22e-17	50600	86.8	69600	85.2	1.02	DOX_DAR_24hr
262	47	MA0691.1	TFAP4	MA0691.1	AWCAGCTGWT	TFAP4	1.26e-14	2.36e-17	4890	8.38	5840	7.16	1.17	DOX_DAR_24hr
263	19	MA1960.1	MGA::EVX1	MA1960.1	RGGTGWTAATKD	MGA::EVX1	2.18e-14	4.06e-17	39200	67.1	53100	65	1.03	DOX_DAR_24hr
264	48	MA1624.1	Stat5a	MA1624.1	NTTCCAAGAANH	Stat5a	2.23e-14	4.14e-17	49200	84.4	67500	82.7	1.02	DOX_DAR_24hr
265	25	MA0768.2	Lef1	MA0768.2	NNBCCTTTGATSTN	Lef1	3.61e-14	6.67e-17	47600	81.6	65200	79.8	1.02	DOX_DAR_24hr
266	48	MA1625.1	Stat5b	MA1625.1	NNNTTCCCAGAANNN	Stat5b	7.89e-14	1.45e-16	49900	85.5	68500	83.8	1.02	DOX_DAR_24hr
267	49	MA0093.3	USF1	MA0093.3	NDGTCATGTGACHN	USF1	9.5e-14	1.74e-16	39000	66.9	52900	64.8	1.03	DOX_DAR_24hr
268	3	MA0854.1	Alx1	MA0854.1	CGMRYTAATTARTNMNY	Alx1	9.92e-14	1.81e-16	20200	34.6	26600	32.5	1.06	DOX_DAR_24hr
269	5	MA0719.1	RHOXF1	MA0719.1	NTRATCCN	RHOXF1	1.08e-13	1.96e-16	54900	94	75900	92.9	1.01	DOX_DAR_24hr
270	32	MA2001.1	Six4	MA2001.1	GDAACCTGANH	Six4	1.85e-13	3.35e-16	54300	93	75000	91.9	1.01	DOX_DAR_24hr
271	66	MA0483.1	Gfi1B	MA0483.1	AAATCWCWGCH	Gfi1B	2.37e-13	4.29e-16	21000	36.1	27700	34	1.06	DOX_DAR_24hr
272	24	MA1645.1	NKX2-2	MA1645.1	NNNCCACTCAANNN	NKX2-2	2.45e-13	4.4e-16	43100	73.9	58700	71.9	1.03	DOX_DAR_24hr
273	31	MA0624.2	Nfatc1	MA0624.2	NVATGGAAAAWN	Nfatc1	6.48e-13	1.16e-15	53700	92	74100	90.8	1.01	DOX_DAR_24hr
274	11	MA0908.1	HOXD11	MA0908.1	RTCGTAAAAH	HOXD11	1.16e-12	2.06e-15	22200	38	29400	36	1.06	DOX_DAR_24hr
275	43	MA0884.2	DUXA	MA0884.2	YTRATTWAATYAR	DUXA	1.18e-12	2.09e-15	10300	17.6	13100	16	1.1	DOX_DAR_24hr
276	10	MA0851.1	Foxj3	MA0851.1	NDAADGTAAACAAANNM	Foxj3	2.32e-12	4.12e-15	35600	61	48100	58.9	1.04	DOX_DAR_24hr
277	24	MA1994.1	Nkx2-1	MA1994.1	NVCACTTGARHNN	Nkx2-1	5.45e-12	9.62e-15	2990	5.12	3460	4.24	1.21	DOX_DAR_24hr
278	24	MA0673.1	NKX2-8	MA0673.1	VCACTTSAV	NKX2-8	7.43e-12	1.31e-14	26400	45.2	35300	43.2	1.05	DOX_DAR_24hr
279	67	MA0508.3	PRDM1	MA0508.3	YNCTTTCTCTH	PRDM1	7.6e-12	1.33e-14	50500	86.6	69500	85.1	1.02	DOX_DAR_24hr
280	66	MA0038.2	GFI1	MA0038.2	BMAATCACDGCA	GFI1	1.65e-11	2.88e-14	13800	23.6	17900	21.9	1.08	DOX_DAR_24hr
281	3	MA0874.1	Arx	MA0874.1	VTBCRYTAATTARTKSW	Arx	2.12e-11	3.69e-14	20700	35.6	27500	33.6	1.06	DOX_DAR_24hr
282	12	MA0078.2	Sox17	MA0078.2	NNAGAACAATGGNN	Sox17	4.61e-11	8e-14	27800	47.7	37300	45.7	1.04	DOX_DAR_24hr
283	47	MA1593.1	ZNF317	MA1593.1	WVACAGCAGAYW	ZNF317	6.53e-11	1.13e-13	47800	82	65600	80.4	1.02	DOX_DAR_24hr
284	24	MA0063.2	NKX2-5	MA0063.2	NNCACTCAANN	NKX2-5	9.69e-11	1.67e-13	56400	96.6	78300	95.8	1.01	DOX_DAR_24hr
285	45	MA1709.1	ZIM3	MA1709.1	RVMAACAGAAACCYM	ZIM3	1.1e-10	1.89e-13	40500	69.4	55100	67.5	1.03	DOX_DAR_24hr
286	50	MA1974.1	ZNF211	MA1974.1	HWYATATACCAYRYW	ZNF211	1.82e-10	3.12e-13	28900	49.5	38800	47.5	1.04	DOX_DAR_24hr
287	17	MA0842.2	NRL	MA0842.2	AAWWNTGCTGACG	NRL	2.28e-10	3.88e-13	4360	7.48	5290	6.48	1.15	DOX_DAR_24hr
288	31	MA0152.2	Nfatc2	MA0152.2	NNRNAATGGAAANWNH	Nfatc2	2.35e-10	3.99e-13	52900	90.6	73100	89.4	1.01	DOX_DAR_24hr
289	3	MA0715.1	PROP1	MA0715.1	TAATYWAATTA	PROP1	4.88e-10	8.26e-13	20900	35.9	27800	34	1.05	DOX_DAR_24hr
290	45	MA0050.3	Irf1	MA0050.3	ANTGAAACTGAAASH	Irf1	5.02e-10	8.47e-13	42000	72	57300	70.2	1.02	DOX_DAR_24hr
291	22	MA1150.1	RORB	MA1150.1	AWWTRGGTCAH	RORB	9.12e-10	1.53e-12	43900	75.2	60100	73.6	1.02	DOX_DAR_24hr
292	3	MA1496.1	HOXA4	MA1496.1	RTMATTAV	HOXA4	3.67e-09	6.15e-12	57100	97.8	79400	97.3	1.01	DOX_DAR_24hr
293	48	MA0144.2	STAT3	MA0144.2	YTTCYKGGAAD	STAT3	5.95e-09	9.93e-12	34500	59.1	46800	57.3	1.03	DOX_DAR_24hr
294	51	MA0671.1	NFIX	MA0671.1	NNTGCCAAN	NFIX	6.58e-09	1.1e-11	57700	98.8	80400	98.4	1	DOX_DAR_24hr
295	52	MA0629.1	Rhox11	MA0629.1	ANKNCGCTGTWAWDVRW	Rhox11	9.76e-09	1.62e-11	47300	81	65000	79.6	1.02	DOX_DAR_24hr
296	17	MA1520.1	MAF	MA1520.1	NTGCTGASTCAGCAH	MAF	1.32e-08	2.19e-11	2340	4	2720	3.33	1.2	DOX_DAR_24hr
297	39	MA0861.1	TP73	MA0861.1	DRCATGTCNNRACAYGYM	TP73	3.09e-08	5.1e-11	1100	1.89	1170	1.44	1.31	DOX_DAR_24hr
298	3	MA1507.1	HOXD4	MA1507.1	VTMATTAD	HOXD4	3.5e-08	5.74e-11	8390	14.4	10800	13.2	1.09	DOX_DAR_24hr
299	44	MA1508.1	IKZF1	MA1508.1	VVAACAGGAARN	IKZF1	4.77e-08	7.8e-11	55600	95.3	77200	94.6	1.01	DOX_DAR_24hr
300	22	MA1139.1	FOSL2::JUNB	MA1139.1	DATGACGTCATH	FOSL2::JUNB	6.75e-08	1.1e-10	32300	55.3	43800	53.6	1.03	DOX_DAR_24hr
301	53	MA1975.1	ZNF214	MA1975.1	VWTCATCAABGTCCT	ZNF214	9.41e-08	1.53e-10	26000	44.6	35100	42.9	1.04	DOX_DAR_24hr
302	22	MA0488.1	JUN	MA0488.1	DDRATGATGTCAT	JUN	2.67e-07	4.32e-10	10500	17.9	13600	16.7	1.08	DOX_DAR_24hr
303	10	MA0614.1	Foxj2	MA0614.1	RTAAACAA	Foxj2	3.85e-07	6.22e-10	17000	29.2	22600	27.7	1.05	DOX_DAR_24hr
304	41	MA1523.1	MSANTD3	MA1523.1	STVCACTCAC	MSANTD3	5.33e-07	8.58e-10	56300	96.5	78300	95.9	1.01	DOX_DAR_24hr
305	11	MA1503.1	HOXB9	MA1503.1	GTCGTAAAAH	HOXB9	7.77e-07	1.25e-09	11400	19.6	14900	18.3	1.07	DOX_DAR_24hr
306	25	MA0869.2	Sox11	MA0869.2	NRGAACAAAGVV	Sox11	8.22e-07	1.31e-09	36300	62.2	49500	60.7	1.03	DOX_DAR_24hr
307	43	MA0468.1	DUX4	MA0468.1	TAAYYYAATCA	DUX4	8.85e-07	1.41e-09	5630	9.66	7120	8.72	1.11	DOX_DAR_24hr
308	42	MA0620.3	MITF	MA0620.3	NNNDRTCACGTGAYHNNN	MITF	1.14e-06	1.81e-09	32600	55.9	44300	54.3	1.03	DOX_DAR_24hr
309	16	MA0773.1	MEF2D	MA0773.1	DCTAWAAATAGM	MEF2D	1.31e-06	2.07e-09	8090	13.9	10400	12.8	1.09	DOX_DAR_24hr
310	27	MA1121.1	TEAD2	MA1121.1	NYACATTCCWNNS	TEAD2	1.6e-06	2.52e-09	37800	64.7	51600	63.2	1.02	DOX_DAR_24hr
311	54	MA0780.1	PAX3	MA0780.1	TAATYRATTA	PAX3	1.64e-06	2.58e-09	15100	25.9	20000	24.5	1.06	DOX_DAR_24hr
312	22	MA1632.1	ATF2	MA1632.1	NNATGABGTCATN	ATF2	1.71e-06	2.68e-09	19000	32.5	25300	31	1.05	DOX_DAR_24hr
313	55	MA0101.1	REL	MA0101.1	BGGRNWTTCC	REL	2.68e-06	4.19e-09	53000	90.8	73400	89.9	1.01	DOX_DAR_24hr
314	39	MA0525.2	TP63	MA0525.2	RACATGTYGKGACATGTC	TP63	2.86e-06	4.46e-09	266	0.46	219	0.27	1.7	DOX_DAR_24hr
315	41	MA0502.2	NFYB	MA0502.2	CYCATTGGCCVV	NFYB	4.16e-06	6.45e-09	3750	6.42	4640	5.68	1.13	DOX_DAR_24hr
316	51	MA0119.1	NFIC::TLX1	MA0119.1	TGGCASSRWGCCAA	NFIC::TLX1	7.63e-06	1.18e-08	4120	7.06	5150	6.3	1.12	DOX_DAR_24hr
317	10	MA0613.1	FOXG1	MA0613.1	RTAAACAW	FOXG1	7.98e-06	1.23e-08	21200	36.4	28500	34.9	1.04	DOX_DAR_24hr
318	48	MA0519.1	Stat5a::Stat5b	MA0519.1	DTTTCCMAGAA	Stat5a::Stat5b	8.54e-06	1.31e-08	30400	52	41300	50.5	1.03	DOX_DAR_24hr
319	3	MA0702.2	LMX1A	MA0702.2	TTAATTAM	LMX1A	1.4e-05	2.14e-08	16600	28.4	22100	27.1	1.05	DOX_DAR_24hr
320	56	MA0494.1	Nr1h3::Rxra	MA0494.1	TGACCTNNAGTRACCYYDN	Nr1h3::Rxra	1.63e-05	2.5e-08	47500	81.4	65500	80.2	1.01	DOX_DAR_24hr
321	57	MA1116.1	RBPJ	MA1116.1	BVTGGGAANN	RBPJ	1.82e-05	2.77e-08	50500	86.5	69800	85.5	1.01	DOX_DAR_24hr
322	58	MA0693.3	Vdr	MA0693.3	NNGAGTTCANN	Vdr	1.83e-05	2.77e-08	57000	97.8	79500	97.3	1	DOX_DAR_24hr
323	47	MA0667.1	MYF6	MA0667.1	AACARCTGTT	MYF6	2.2e-05	3.32e-08	14700	25.2	19500	23.9	1.05	DOX_DAR_24hr
324	59	MA1729.1	ZNF680	MA1729.1	GNCCAAGAAGAATDA	ZNF680	2.24e-05	3.39e-08	28800	49.4	39200	48	1.03	DOX_DAR_24hr
325	56	MA1151.1	RORC	MA1151.1	NWAWNTRGGTCA	RORC	2.43e-05	3.66e-08	55500	95.1	77100	94.4	1.01	DOX_DAR_24hr
326	11	MA1506.1	HOXD10	MA1506.1	RGTCGTAAAAH	HOXD10	2.47e-05	3.7e-08	11800	20.3	15600	19.1	1.06	DOX_DAR_24hr
327	60	MA1478.1	DMRTA2	MA1478.1	AATTGHTACAWT	DMRTA2	2.53e-05	3.79e-08	52100	89.4	72200	88.4	1.01	DOX_DAR_24hr
328	21	MA0837.2	CEBPE	MA0837.2	KATTGCGCAATM	CEBPE	2.87e-05	4.28e-08	5400	9.26	6880	8.43	1.1	DOX_DAR_24hr
329	12	MA0087.2	Sox5	MA0087.2	VRVAACAATGGNN	Sox5	3.68e-05	5.48e-08	32500	55.7	44300	54.2	1.03	DOX_DAR_24hr
330	30	MA0040.1	Foxq1	MA0040.1	HATTGTTTATW	Foxq1	5.15e-05	7.64e-08	16400	28.1	21900	26.8	1.05	DOX_DAR_24hr
331	21	MA0639.1	DBP	MA0639.1	NRTTACGTAAYV	DBP	7.13e-05	1.05e-07	14500	24.8	19200	23.6	1.05	DOX_DAR_24hr
332	61	MA1592.1	ZNF274	MA1592.1	NRTRTGAGTTCTCGYN	ZNF274	7.45e-05	1.1e-07	10500	18.1	13900	17	1.06	DOX_DAR_24hr
333	22	MA0492.1	JUND	MA0492.1	DDDRATGABGTCATN	JUND	8e-05	1.18e-07	9980	17.1	13100	16	1.07	DOX_DAR_24hr
334	42	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	0.000107	1.56e-07	7660	13.1	9960	12.2	1.08	DOX_DAR_24hr
335	36	MA0829.2	SREBF1	MA0829.2	DNATCACSTGATNH	SREBF1	0.000341	4.98e-07	6510	11.2	8430	10.3	1.08	DOX_DAR_24hr
336	62	MA0802.1	TBR1	MA0802.1	AGGTGTGAAA	TBR1	0.000346	5.03e-07	36100	62	49500	60.6	1.02	DOX_DAR_24hr
337	42	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	0.000388	5.63e-07	7380	12.6	9620	11.8	1.07	DOX_DAR_24hr
338	11	MA0906.1	HOXC12	MA0906.1	RGTCGTAAAAH	HOXC12	0.000449	6.49e-07	16700	28.7	22500	27.5	1.04	DOX_DAR_24hr
339	11	MA0907.1	HOXC13	MA0907.1	BCTCGTAAAAH	HOXC13	0.00048	6.92e-07	17500	30	23600	28.8	1.04	DOX_DAR_24hr
340	27	MA0114.4	HNF4A	MA0114.4	DNCAAAGTCCANN	HNF4A	0.000493	7.1e-07	54100	92.7	75100	92	1.01	DOX_DAR_24hr
341	16	MA0660.1	MEF2B	MA0660.1	RCTAWAAATAGC	MEF2B	0.000608	8.72e-07	8000	13.7	10500	12.8	1.07	DOX_DAR_24hr
342	46	MA1111.1	NR2F2	MA1111.1	NAAAGGTCANR	NR2F2	0.000981	1.4e-06	39300	67.3	54000	66.1	1.02	DOX_DAR_24hr
343	17	MA1521.1	MAFA	MA1521.1	NTGCTGASTCAGCAN	MAFA	0.00142	2.03e-06	1670	2.86	2000	2.45	1.17	DOX_DAR_24hr
11	66	MA0483.1 (Gfi1B)	MEME-7	AATCCCAGCWMYTTG	AATCCCAGCWMYTTG	Gfi1B	0.00173	0.000157	283	0.49	289	0.35	1.37	DOX_DAR_24hr
344	11	MA0873.1	HOXD12	MA0873.1	RGTCGTAAAAH	HOXD12	0.00206	2.93e-06	12700	21.7	16900	20.7	1.05	DOX_DAR_24hr
345	12	MA0515.1	Sox6	MA0515.1	CCWTTGTYYY	Sox6	0.00243	3.45e-06	12500	21.4	16600	20.4	1.05	DOX_DAR_24hr
346	42	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	0.00252	3.56e-06	7210	12.4	9440	11.6	1.07	DOX_DAR_24hr
347	43	MA1720.1	ZNF85	MA1720.1	DHDGAGATTACWKCAK	ZNF85	0.0031	4.36e-06	12100	20.7	16100	19.7	1.05	DOX_DAR_24hr
348	10	MA0849.1	FOXO6	MA0849.1	GTAAACA	FOXO6	0.00363	5.1e-06	30700	52.7	42000	51.5	1.02	DOX_DAR_24hr
349	22	MA1133.1	JUN::JUNB	MA1133.1	KRTGACGTCATN	JUN::JUNB	0.00368	5.15e-06	40500	69.5	55800	68.4	1.02	DOX_DAR_24hr
350	51	MA1643.1	NFIB	MA1643.1	NNCCTGGCAYNGTGCCAAGNN	NFIB	0.00447	6.25e-06	2360	4.04	2920	3.58	1.13	DOX_DAR_24hr
351	62	MA0800.1	EOMES	MA0800.1	RAGGTGTGAAAWN	EOMES	0.0047	6.55e-06	50800	87.1	70500	86.3	1.01	DOX_DAR_24hr
352	63	MA0761.2	ETV1	MA0761.2	NNACAGGAAGTGNN	ETV1	0.00575	7.99e-06	57200	98.1	79800	97.8	1	DOX_DAR_24hr
353	51	MA1527.1	NFIC	MA1527.1	NTTGGCDNNRTGCCARN	NFIC	0.0086	1.19e-05	3480	5.96	4430	5.43	1.1	DOX_DAR_24hr
354	42	MA0743.2	SCRT1	MA0743.2	NDWKCAACAGGTGKNN	SCRT1	0.0108	1.49e-05	46300	79.3	64000	78.4	1.01	DOX_DAR_24hr
355	3	MA0135.1	Lhx3	MA0135.1	WAATTAATTAWYY	Lhx3	0.0124	1.71e-05	10100	17.4	13500	16.5	1.05	DOX_DAR_24hr
356	64	MA0631.1	Six3	MA0631.1	DATRGGGTATCAYNWNT	Six3	0.0173	2.38e-05	16100	27.7	21800	26.7	1.04	DOX_DAR_24hr
357	49	MA1524.2	Msgn1	MA1524.2	VRRRACAAATGGTNNN	Msgn1	0.0179	2.45e-05	21500	36.9	29300	35.9	1.03	DOX_DAR_24hr
358	3	MA0683.1	POU4F2	MA0683.1	RTGCATAATTAATGAG	POU4F2	0.019	2.59e-05	3620	6.21	4640	5.68	1.09	DOX_DAR_24hr
359	62	MA1567.2	Tbx6	MA1567.2	NRGGTGTGAANN	Tbx6	0.02	2.72e-05	19500	33.5	26500	32.4	1.03	DOX_DAR_24hr
360	22	MA1129.1	FOSL1::JUN	MA1129.1	ATGACGTCAT	FOSL1::JUN	0.0258	3.51e-05	36500	62.5	50200	61.4	1.02	DOX_DAR_24hr
361	21	MA0838.1	CEBPG	MA0838.1	ATTRCGCAAY	CEBPG	0.0264	3.57e-05	18800	32.3	25500	31.3	1.03	DOX_DAR_24hr
362	65	MA0258.2	ESR2	MA0258.2	AGGTCASVNTGMCCY	ESR2	0.0281	3.8e-05	47400	81.2	65600	80.3	1.01	DOX_DAR_24hr
363	48	MA0518.1	Stat4	MA0518.1	YTTCYRGGAARNVR	Stat4	0.0291	3.92e-05	28700	49.1	39200	48.1	1.02	DOX_DAR_24hr
364	63	MA1952.1	FOXJ2::ELF1	MA1952.1	RTAAACMGGAAGTR	FOXJ2::ELF1	0.0407	5.46e-05	52700	90.3	73200	89.7	1.01	DOX_DAR_24hr
365	46	MA0643.1	Esrrg	MA0643.1	TCAAGGTCAH	Esrrg	0.0446	5.98e-05	21100	36.2	28700	35.2	1.03	DOX_DAR_24hr
12	67	MA0508.3 (PRDM1)	MEME-3	AVAGAGARAGAGARA	AVAGAGARAGAGARA	PRDM1	0.0471	0.00393	6950	11.9	9330	11.4	1.04	DOX_DAR_24hr
366	3	MA0621.1	mix-a	MA0621.1	NDTTAATTAGN	mix-a	0.0499	6.66e-05	10400	17.8	13900	17	1.05	DOX_DAR_24hr
13	68	GAGGTTGCAGTGAGC	MEME-4	GAGGTTGCAGTGAGC	GAGGTTGCAGTGAGC	GAGGTTGCAGTGAGC	0.34	0.0262	411	0.7	500	0.61	1.15	DOX_DAR_24hr
14	69	MA1581.1 (ZBTB6)	MEME-8	CTTGARCCCAGGAGK	CTTGARCCCAGGAGK	ZBTB6	0.719	0.0514	49	0.08	47	0.06	1.46	DOX_DAR_24hr
15	70	MA1107.2 (KLF9)	MEME-5	ACACACACACACACA	ACACACACACACACA	KLF9	1.8	0.12	16	0.03	13	0.02	1.7	DOX_DAR_24hr
16	71	MA1999.1 (Prdm5)	MEME-6	ACTGCACTCCAGCCT	ACTGCACTCCAGCCT	Prdm5	2.43	0.152	301	0.52	386	0.47	1.09	DOX_DAR_24hr
17	67	MA1125.1 (ZNF384)	MEME-1	TTTTTTTTTTTTTTT	TTTTTTTTTTTTTTT	ZNF384	4.13	0.243	4160	7.13	5740	7.03	1.01	DOX_DAR_24hr
18	72	MA1596.1 (ZNF460)	MEME-9	GGARGCTG	GGARGCTG	ZNF460	16	0.889	959	1.64	1410	1.73	0.952	DOX_DAR_24hr

ER_rat <- 1.25
mrc_type <- "DOX_DAR_24hr"
DOX_DAR_24hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DOX_DAR_24hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  dplyr::filter(EVALUE.y<0.05) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*.8), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.8,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DOX_sigup_24hr data

DOX_sigup_24hr_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_up_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DOX_sigup_24hr_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_up_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DOX_sigup_24hr_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_up_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DOX_sigup_24hr_sea_all <- rbind(DOX_sigup_24hr_sea_disc, DOX_sigup_24hr_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DOX_24_up_combo <-DOX_sigup_24hr_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DOX_sigup_24hr_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

DOX_24_up_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in DOX_24sig up") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in DOX_24sig up
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA1134.1 (FOS::JUNB)	STREME-1	1-DATGASTCATH	DATGASTCATH	FOS::JUNB	0	0	14000	48	1740	5.97	8.03
2	1	MA1130.1 (FOSL2::JUN)	MEME-1	RTGACTCAKHH	RTGACTCAKHH	FOSL2::JUN	0	0	13200	45.3	1370	4.71	9.61
3	1	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	0	0	13500	46.2	1560	5.36	8.62
4	1	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	0	0	12500	42.8	1150	3.95	10.8
5	1	MA0462.2 (BATF::JUN)	STREME-4	4-ATGASTCAT	ATGASTCAT	BATF::JUN	0	0	13600	46.3	1630	5.61	8.25
6	1	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	0	0	13300	45.5	1520	5.24	8.69
7	1	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	0	0	13500	46.2	1640	5.66	8.16
8	1	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	0	0	13200	45	1510	5.2	8.66
9	1	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	0	0	12900	44	1370	4.71	9.32
10	1	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	0	0	13000	44.4	1440	4.97	8.94
11	1	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	0	0	12400	42.3	1180	4.05	10.4
12	1	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	0	0	12700	43.3	1320	4.53	9.56
13	1	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	0	0	13200	45.2	1600	5.49	8.24
14	1	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	0	0	12500	42.7	1250	4.29	9.94
15	1	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	0	0	12200	41.8	1150	3.96	10.5
16	1	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	0	0	13900	47.6	2000	6.87	6.92
17	1	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	0	0	12400	42.3	1230	4.24	9.96
18	1	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	0	0	12800	43.6	1420	4.9	8.9
19	1	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	0	0	13100	44.6	1590	5.46	8.16
20	1	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	0	0	13500	46.1	1860	6.4	7.2
21	1	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	0	0	12200	41.6	1230	4.24	9.8
22	1	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	0	0	12600	43	1470	5.05	8.51
23	1	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	0	0	12300	41.9	1310	4.51	9.28
24	1	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	0	0	12800	43.8	1820	6.24	7.02
25	1	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	0	0	11500	39.3	1240	4.25	9.24
26	1	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	0	0	13700	46.7	2520	8.68	5.38
27	1	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	0	0	11900	40.8	1650	5.66	7.2
28	1	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	0	0	12900	44	2190	7.52	5.84
29	1	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	0	0	11000	37.7	1390	4.77	7.9
30	1	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	0	0	10700	36.6	2760	9.48	3.86
31	1	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	0	0	10400	35.7	2600	8.94	3.99
32	1	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	0	0	12500	42.8	4380	15.1	2.84
33	1	MA0150.2	Nfe2l2	MA0150.2	CASNATGACTCAGCA	Nfe2l2	0	0	13600	46.6	6140	21.1	2.2
34	1	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	0	0	10400	35.4	4240	14.6	2.43
35	2	MA0676.1	Nr2e1	MA0676.1	AAAAGTCAA	Nr2e1	0	0	21800	74.7	15700	54.1	1.38
36	3	20-AWGWCWT	STREME-20	20-AWGWCWT	20-AWGWCWT	AWGWCWT	0	0	21800	74.6	15900	54.5	1.37
37	4	MA0791.1	POU4F3	MA0791.1	RTGMATWATTAATGAR	POU4F3	0	0	19200	65.7	13100	44.9	1.46
38	4	MA0790.1	POU4F1	MA0790.1	ATGMATAATTAATG	POU4F1	0	0	21100	72.1	15200	52.2	1.38
39	1	MA1113.2	PBX2	MA1113.2	NHCATAAATCAHN	PBX2	0	0	20100	68.5	14100	48.3	1.42
40	5	MA1978.1	ZNF354A	MA1978.1	HWAADWATAAATGRAYWAWTT	ZNF354A	0	0	22100	75.5	16500	56.8	1.33
41	6	MA1143.1	FOSL1::JUND	MA1143.1	RTGACGTMAY	FOSL1::JUND	0	0	22700	77.5	17200	59.1	1.31
42	1	MA1640.1	MEIS2	MA1640.1	NNATGATTTATGDNH	MEIS2	0	0	21100	72	15400	52.9	1.36
43	4	MA0046.2	HNF1A	MA0046.2	DRTTAATNATTAACN	HNF1A	0	0	17000	58	11200	38.4	1.51
44	7	MA0851.1 (Foxj3)	STREME-2	2-AAACAAAWAHAW	AAACAAAWAHAW	Foxj3	0	0	19000	64.8	13200	45.3	1.43
45	8	MA0681.2	PHOX2B	MA0681.2	WWTAATCAAATTAWWW	PHOX2B	0	0	21000	71.9	15400	53	1.36
46	8	MA0680.2	Pax7	MA0680.2	DWTAATCAATTAWNH	Pax7	0	0	22200	75.7	16700	57.4	1.32
47	1	MA1639.1	MEIS1	MA1639.1	NHCATMAATCAHN	MEIS1	0	0	21500	73.4	15900	54.8	1.34
48	9	MA1588.1 (ZNF136)	STREME-11	11-AAGAAT	11-AAGAAT	ZNF136	0	0	23300	79.8	18200	62.4	1.28
49	4	MA0153.2	HNF1B	MA0153.2	GTTAATNATTAAY	HNF1B	0	0	16600	56.8	11000	37.7	1.51
50	10	MA0788.1	POU3F3	MA0788.1	WWTATGCWAATTW	POU3F3	0	0	22200	75.8	17000	58.5	1.3
51	11	MA0886.1	EMX2	MA0886.1	VBTAATTARB	EMX2	0	0	23400	80	18500	63.5	1.26
52	7	MA1125.1 (ZNF384)	MEME-2	TTTTTTTTTTTTTTT	TTTTTTTTTTTTTTT	ZNF384	0	0	16100	55.1	10700	36.9	1.49
53	12	3-AAWWWWTT	STREME-3	3-AAWWWWTT	AAWWWWTT	AAWWWWTT	0	0	23200	79.2	18200	62.7	1.26
54	13	MA0679.2	ONECUT1	MA0679.2	WAAAAATCAATAAWWN	ONECUT1	0	0	20100	68.6	14800	50.8	1.35
55	10	MA0786.1	POU3F1	MA0786.1	WTATGCWAATKW	POU3F1	0	0	24100	82.4	19400	66.7	1.24
56	14	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	0	0	23000	78.5	18100	62.1	1.26
57	14	MA0032.2	FOXC1	MA0032.2	WAWGTAAAYAW	FOXC1	0	0	22300	76.3	17400	59.7	1.28
58	8	MA0715.1	PROP1	MA0715.1	TAATYWAATTA	PROP1	0	0	16500	56.3	11200	38.6	1.46
59	15	MA0901.2	HOXB13	MA0901.2	WDCCAATAAAAWWW	HOXB13	0	0	24000	81.9	19300	66.5	1.23
60	15	MA1125.1	ZNF384	MA1125.1	DNWMAAAAAAAA	ZNF384	0	0	17500	59.7	12200	42	1.42
61	16	18-AAATGA	STREME-18	18-AAATGA	18-AAATGA	AAATGA	0	0	20500	70	15400	52.8	1.33
62	10	MA0142.1	Pou5f1::Sox2	MA0142.1	CWTTGTYATGCAAAT	Pou5f1::Sox2	0	0	22300	76.3	17400	59.9	1.27
63	10	MA0787.1	POU3F2	MA0787.1	WTATGCWAATKA	POU3F2	0	0	23100	79	18400	63.2	1.25
64	11	MA0902.2	HOXB2	MA0902.2	SYAATTAS	HOXB2	0	0	22000	75	17100	58.6	1.28
65	11	MA0628.1	POU6F1	MA0628.1	AYTAATTART	POU6F1	0	0	24400	83.2	19900	68.4	1.22
66	8	MA0713.1	PHOX2A	MA0713.1	TAATYYAATTA	PHOX2A	0	0	20800	71.2	15900	54.5	1.31
67	36	MA0052.4	MEF2A	MA0052.4	DDCTAAAAATAGMHH	MEF2A	0	0	22700	77.7	18000	61.9	1.26
68	14	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	0	0	19500	66.6	14400	49.7	1.34
69	17	MA1471.1	BARX2	MA1471.1	NWWAAYMATTAN	BARX2	0	0	22800	78.1	18100	62.4	1.25
70	10	MA0785.1	POU2F1	MA0785.1	AWTATGCWAATK	POU2F1	0	0	22700	77.7	18000	62	1.25
71	18	MA1125.1 (ZNF384)	STREME-5	5-AAAAAA	AAAAAA	ZNF384	0	0	20500	70.1	15500	53.4	1.31
72	11	MA1963.1	SATB1	MA1963.1	WWDCTAATAAHWW	SATB1	0	0	20200	69.1	15300	52.6	1.31
73	19	MA1603.1	Dmrt1	MA1603.1	GHTACAAAGTADC	Dmrt1	0	0	24900	85	20700	71	1.2
74	14	MA0041.2	FOXD3	MA0041.2	WAWGHAAATAAACARY	FOXD3	0	0	25000	85.6	20900	72	1.19
75	20	MA0025.2	NFIL3	MA0025.2	NRTTATGYAATNN	NFIL3	0	0	24300	83.1	20000	68.9	1.21
76	10	MA0627.2	POU2F3	MA0627.2	NWTATGCAAATNH	POU2F3	0	0	24900	85	20700	71.3	1.19
77	21	MA0602.1	Arid5a	MA0602.1	SYAATATTGVDANH	Arid5a	0	0	21800	74.4	17100	58.7	1.27
78	14	MA1607.1	Foxl2	MA1607.1	DDWATGTAAACANN	Foxl2	0	0	23300	79.7	18900	64.9	1.23
79	20	MA1636.1	CEBPG	MA1636.1	NDATGATGCAATMHH	CEBPG	0	0	22200	75.8	17600	60.4	1.25
80	11	MA1549.1	POU6F1	MA1549.1	RTAATGAGVN	POU6F1	0	0	22900	78.1	18400	63.3	1.23
81	22	7-AAWWTT	STREME-7	7-AAWWTT	AAWWTT	AAWWTT	0	0	21500	73.4	16900	58	1.26
82	23	MA0611.2	Dux	MA0611.2	NTGATTBAATCAVWNN	Dux	0	0	12700	43.4	8130	28	1.55
83	11	MA0722.1	VAX1	MA0722.1	YTAATTAH	VAX1	0	0	23200	79.4	18900	65	1.22
84	14	MA1487.2	FOXE1	MA1487.2	VYTAAAYAAACAAH	FOXE1	0	0	17300	59	12500	42.9	1.38
85	11	MA0793.1	POU6F2	MA0793.1	ASCTMATTAW	POU6F2	0	0	24100	82.3	19900	68.6	1.2
86	11	MA0723.2	VAX2	MA0723.2	BYAATTAV	VAX2	0	0	22200	75.7	17700	60.8	1.25
87	11	MA0706.1	MEOX2	MA0706.1	DSTAATTAWN	MEOX2	0	0	22000	75.1	17500	60.1	1.25
88	1	MA0591.1	Bach1::Mafk	MA0591.1	RSSATGACTCAGCAB	Bach1::Mafk	0	0	3300	11.3	931	3.2	3.52
89	24	MA1152.1	SOX15	MA1152.1	CYWTTGTTHW	SOX15	7.26276499386632e-322	7.26276499386632e-322	24500	83.6	20400	70.2	1.19
90	11	MA0710.1	NOTO	MA0710.1	NYTAATTAVN	NOTO	4.29837111881884e-321	4.29837111881884e-321	22700	77.6	18300	63.1	1.23
91	24	MA0084.1	SRY	MA0084.1	NWWAACAAT	SRY	1.12997753860351e-319	4.74303020007597e-322	20300	69.4	15700	54	1.29
92	25	MA1124.1	ZNF24	MA1124.1	CATTCATTCATTC	ZNF24	1.1899999929067e-316	5.16002160516598e-319	17300	59.1	12600	43.3	1.36
93	26	MA0905.1	HOXC10	MA0905.1	GTCRTAAAAH	HOXC10	1.34999999029226e-316	5.78002458413216e-319	24600	84	20600	70.9	1.19
94	10	MA1115.1	POU5F1	MA1115.1	WHATGCAAATN	POU5F1	2.57000000000105e-315	1.09000021687027e-317	25200	86.1	21400	73.6	1.17
95	14	MA0148.4	FOXA1	MA0148.4	WWGTAAACATNN	FOXA1	4.9999999998194e-314	2.09999999038868e-316	24500	83.8	20500	70.6	1.19
96	10	MA0789.1	POU3F4	MA0789.1	TATGCWAAT	POU3F4	7.03999999998287e-313	2.92000000169293e-315	23700	81.1	19600	67.4	1.2
97	26	MA0908.1	HOXD11	MA0908.1	RTCGTAAAAH	HOXD11	9.99999999999997e-311	4.12000000001917e-313	16400	56.2	11800	40.6	1.39
98	15	MA0650.3	Hoxa13	MA0650.3	NNCCAATAAAAN	Hoxa13	1.51e-310	6.11999999999634e-313	23100	79	18900	65	1.22
99	14	MA0847.3	FOXD2	MA0847.3	SYTAARYAAACA	FOXD2	2.11000000000002e-310	8.48000000001979e-313	20300	69.5	15800	54.3	1.28
100	10	MA0792.1	POU5F1B	MA0792.1	TATGCWAAT	POU5F1B	4.56000000000002e-310	1.81999999999849e-312	25100	85.8	21300	73.3	1.17
101	11	MA0601.1	Arid3b	MA0601.1	ATATTAATWAN	Arid3b	1.32e-307	5.18999999999999e-310	19800	67.8	15300	52.5	1.29
102	36	MA0497.1	MEF2C	MA0497.1	DDDCYAAAAATAGMW	MEF2C	1.86e-307	7.27000000000001e-310	21800	74.4	17400	59.8	1.24
103	7	MA0851.1	Foxj3	MA0851.1	NDAADGTAAACAAANNM	Foxj3	6.91e-304	2.67e-306	20600	70.4	16100	55.4	1.27
104	20	MA0043.3	HLF	MA0043.3	NNRTTATGCAACHN	HLF	4.91e-302	1.88e-304	21000	71.6	16500	56.9	1.26
105	15	MA0465.2	CDX2	MA0465.2	NDGCAATAAAWN	CDX2	2.12e-301	8.02e-304	23200	79.3	19100	65.6	1.21
106	11	MA1481.1	DRGX	MA1481.1	YYAATTAN	DRGX	7.91e-301	2.97e-303	21500	73.5	17100	58.9	1.25
107	20	MA0102.4	CEBPA	MA0102.4	NDATTGCACAATHN	CEBPA	2.38e-300	8.85e-303	19900	68.2	15500	53.1	1.28
108	27	MA0495.3	MAFF	MA0495.3	DWGTCAGCATTTTWHN	MAFF	1.75e-296	6.44e-299	24300	83.1	20400	70.2	1.18
109	28	MA1657.1	ZNF652	MA1657.1	BAAAGRGTTAAN	ZNF652	4.7e-295	1.71e-297	23400	79.9	19300	66.4	1.2
110	26	MA0911.1	Hoxa11	MA0911.1	RGTCGTAAAANT	Hoxa11	7.02e-293	2.54e-295	24600	84.2	20800	71.6	1.18
111	11	MA0903.1	HOXB3	MA0903.1	NNYMATTARN	HOXB3	1.5e-290	5.4e-293	21000	71.7	16700	57.3	1.25
112	14	MA1489.1	FOXN3	MA1489.1	GTAAACAA	FOXN3	2.34e-286	8.33e-289	22200	75.8	18000	61.8	1.22
113	11	MA0068.2	PAX4	MA0068.2	CTAATTAG	PAX4	1.5e-274	5.27e-277	23500	80.2	19600	67.3	1.19
114	29	14-ATGWTC	STREME-14	14-ATGWTC	14-ATGWTC	ATGWTC	1.97e-274	6.88e-277	21300	72.8	17100	58.8	1.24
115	13	MA0757.1	ONECUT3	MA0757.1	AAAAAATCRATAAH	ONECUT3	1.7e-273	5.88e-276	11600	39.7	7550	26	1.53
116	11	MA0674.1	NKX6-1	MA0674.1	NTMATTAA	NKX6-1	2.83e-273	9.70999999999999e-276	21500	73.6	17400	59.8	1.23
117	11	MA0895.1	HMBOX1	MA0895.1	MYTAGTTAMS	HMBOX1	4.02e-273	1.37e-275	22200	75.9	18100	62.4	1.22
118	11	MA0899.1	HOXA10	MA0899.1	DGYMATAAAAH	HOXA10	1.24e-272	4.2e-275	24900	85	21200	73.1	1.16
119	13	MA0755.1	CUX2	MA0755.1	TRATCGATAW	CUX2	6.39e-270	2.14e-272	22200	75.8	18100	62.3	1.22
120	11	MA0910.2	HOXD8	MA0910.2	GYMATTAM	HOXD8	2.7e-268	8.94e-271	17500	59.8	13200	45.3	1.32
121	14	MA0031.1	FOXD1	MA0031.1	GTAAACAW	FOXD1	6.13e-268	2.02e-270	23200	79.1	19300	66.2	1.2
122	14	MA0047.3	FOXA2	MA0047.3	RWGTAAACANN	FOXA2	1.17e-267	3.81e-270	23400	79.9	19500	67.1	1.19
123	30	MA1623.1	Stat2	MA1623.1	RGAAACAGAAASH	Stat2	3.03e-267	9.8e-270	26000	88.9	22700	78.2	1.14
124	11	MA0658.1	LHX6	MA0658.1	RCTAATTARY	LHX6	9.34999999999999e-267	3e-269	19800	67.8	15600	53.6	1.26
125	11	MA0612.2	EMX1	MA0612.2	BTAATTAS	EMX1	9.42e-267	3e-269	16300	55.6	12000	41.2	1.35
126	11	MA0675.1	NKX6-2	MA0675.1	NYMATTAA	NKX6-2	1.97e-266	6.22e-269	20300	69.3	16100	55.2	1.25
127	11	MA0704.1	Lhx4	MA0704.1	YTAATTAR	Lhx4	1.13e-265	3.53e-268	22000	75.1	17900	61.6	1.22
128	31	MA0606.2	Nfat5	MA0606.2	NNATGGAAAAWN	Nfat5	1.65e-263	5.12e-266	23900	81.6	20100	69.3	1.18
129	20	MA0836.2	CEBPD	MA0836.2	NRTTGCACAAYHN	CEBPD	4.16e-261	1.28e-263	20500	70.1	16400	56.3	1.25
130	30	MA0050.3	Irf1	MA0050.3	ANTGAAACTGAAASH	Irf1	7.16e-258	2.19e-260	26200	89.5	23000	79.2	1.13
131	14	MA0040.1	Foxq1	MA0040.1	HATTGTTTATW	Foxq1	1.62e-257	4.93e-260	12100	41.5	8120	27.9	1.49
132	24	MA0868.2	SOX8	MA0868.2	MGAACAATRG	SOX8	1.02e-256	3.08e-259	19100	65.4	14900	51.4	1.27
133	14	MA0852.2	FOXK1	MA0852.2	NRDGTAAACAAGNN	FOXK1	1.51e-256	4.51e-259	24600	84.1	21100	72.4	1.16
134	11	MA0158.2	HOXA5	MA0158.2	GYMATTAS	HOXA5	1.59e-253	4.73e-256	17200	58.7	13000	44.6	1.32
135	11	MA1502.1	HOXB8	MA1502.1	GYMATTAM	HOXB8	2.12e-251	6.26e-254	16500	56.5	12300	42.4	1.33
136	32	MA0108.2	TBP	MA0108.2	STATAAAWRSVVVBN	TBP	1.07e-250	3.14e-253	22900	78.1	19000	65.5	1.19
137	14	MA0157.3	Foxo3	MA0157.3	NDGTAAACARNN	Foxo3	1.19e-250	3.47e-253	25800	88.2	22600	77.7	1.14
138	11	MA0887.1	EVX1	MA0887.1	VVTAATTABS	EVX1	3.32e-250	9.59e-253	22100	75.5	18200	62.5	1.21
139	14	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	4.39e-249	1.26e-251	26500	90.6	23500	80.9	1.12
140	11	MA1498.2	HOXA7	MA1498.2	SYMATTAV	HOXA7	1.5e-248	4.25e-251	19600	67.2	15500	53.5	1.26
141	33	MA1729.1	ZNF680	MA1729.1	GNCCAAGAAGAATDA	ZNF680	4.45e-248	1.26e-250	18800	64.3	14700	50.4	1.27
142	11	MA1463.1	ARGFX	MA1463.1	DCTAATTARM	ARGFX	1.22e-247	3.41e-250	16000	54.8	11900	40.9	1.34
143	11	MA1518.2	Lhx1	MA1518.2	NNNTGCTAATTAGCANNN	Lhx1	4.03e-247	1.12e-249	22300	76.2	18400	63.4	1.2
144	14	MA1103.2	FOXK2	MA1103.2	DDGTAAACANN	FOXK2	6.55e-247	1.81e-249	26600	90.8	23600	81.2	1.12
145	11	MA0716.1	PRRX1	MA0716.1	YYAATTAR	PRRX1	3.16e-244	8.66999999999999e-247	21000	71.7	17000	58.5	1.23
146	14	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	8.49e-244	2.32e-246	26800	91.7	24000	82.5	1.11
147	11	MA0892.1	GSX1	MA0892.1	NCYMATTAVN	GSX1	7.05e-243	1.91e-245	23000	78.5	19200	66.1	1.19
148	11	MA0718.1	RAX	MA0718.1	RYYAATTARH	RAX	2.45e-242	6.58e-245	24400	83.5	20900	72	1.16
149	11	MA0725.1	VSX1	MA0725.1	YTAATTAN	VSX1	6.33e-241	1.69e-243	16800	57.5	12700	43.8	1.31
150	11	MA0662.1	MIXL1	MA0662.1	NBYAATTAVN	MIXL1	2.88e-240	7.65e-243	21800	74.5	17900	61.6	1.21
151	24	MA0143.4	SOX2	MA0143.4	DNACAATGGNN	SOX2	3.02e-240	7.97e-243	20200	69.2	16200	55.8	1.24
152	15	MA0913.2	HOXD9	MA0913.2	GYMATAAAAH	HOXD9	5.16e-240	1.35e-242	19200	65.6	15100	52.1	1.26
153	34	MA0035.4	GATA1	MA0035.4	NHCTAATCTDH	GATA1	7.54e-240	1.96e-242	22700	77.7	19000	65.4	1.19
154	11	MA1505.1	HOXC8	MA1505.1	KTAATTAM	HOXC8	1.45e-239	3.74e-242	16100	55	12000	41.3	1.33
155	11	MA0132.2	PDX1	MA0132.2	VYAATTAR	PDX1	2.49e-239	6.4e-242	15500	52.8	11400	39.2	1.35
156	11	MA0726.1	VSX2	MA0726.1	CTAATTAN	VSX2	6.4e-239	1.63e-241	24800	84.7	21400	73.6	1.15
157	11	MA0125.1	Nobox	MA0125.1	TAATTRSY	Nobox	4.51e-238	1.14e-240	21600	73.9	17800	61.1	1.21
158	10	MA1962.1	POU2F1::SOX2	MA1962.1	MATTTRCATMACAATRG	POU2F1::SOX2	6.9e-238	1.74e-240	11500	39.2	7660	26.3	1.49
159	11	MA0654.1	ISX	MA0654.1	YYAATTAR	ISX	2.85e-235	7.14e-238	20300	69.4	16400	56.2	1.23
160	11	MA0635.1	BARHL2	MA0635.1	VHTAAAYGRT	BARHL2	1.72e-234	4.28e-237	23400	80	19800	68	1.17
161	11	MA0075.3	PRRX2	MA0075.3	CTAATTAN	PRRX2	1.53e-233	3.78e-236	15400	52.6	11400	39	1.35
162	14	MA0613.1	FOXG1	MA0613.1	RTAAACAW	FOXG1	1.94e-233	4.78e-236	14800	50.5	10800	37.1	1.36
163	11	MA0909.3	Hoxd13	MA0909.3	NNCAATAAAW	Hoxd13	2.68e-231	6.54e-234	20400	69.6	16500	56.6	1.23
164	11	MA0888.1	EVX2	MA0888.1	VVTAATTAVB	EVX2	2.61e-230	6.34e-233	25900	88.7	22900	78.8	1.13
165	35	MA1480.1	DPRX	MA1480.1	AGATAATCCN	DPRX	5.04e-230	1.22e-232	26000	88.8	23000	78.9	1.12
166	11	MA0720.1	Shox2	MA0720.1	YYAATTAR	Shox2	1.39e-229	3.34e-232	19000	64.8	15000	51.5	1.26
167	14	MA0481.3	FOXP1	MA0481.3	NDGTAAACANH	FOXP1	1.11e-227	2.64e-230	27600	94.2	25100	86.3	1.09
168	11	MA0721.1	UNCX	MA0721.1	YYAATTAV	UNCX	1.55e-227	3.68e-230	22200	76	18500	63.8	1.19
169	11	MA0027.2	EN1	MA0027.2	SYAATTAV	EN1	8.04e-227	1.89e-229	25700	88	22700	77.9	1.13
170	11	MA0700.2	LHX2	MA0700.2	DDCCAATTADN	LHX2	1.62e-225	3.79e-228	21300	72.7	17500	60.1	1.21
171	11	MA0717.1	RAX2	MA0717.1	YYAATTAV	RAX2	1.64e-225	3.81e-228	21700	74.3	18000	61.8	1.2
172	11	MA0882.1	DLX6	MA0882.1	VYAATTAN	DLX6	5.62e-225	1.3e-227	25000	85.4	21800	74.8	1.14
173	30	MA1709.1	ZIM3	MA1709.1	RVMAACAGAAACCYM	ZIM3	2.41e-223	5.56e-226	22400	76.6	18800	64.5	1.19
174	20	MA0833.2	ATF4	MA0833.2	DDATGATGCAATMN	ATF4	4.47e-223	1.02e-225	19800	67.6	15900	54.7	1.24
175	35	MA0682.2	PITX1	MA0682.2	YTAATCCH	PITX1	4.34e-221	9.86999999999999e-224	18700	64	14800	51	1.26
176	4	MA0683.1	POU4F2	MA0683.1	RTGCATAATTAATGAG	POU4F2	1.33e-220	3.01e-223	7240	24.7	4160	14.3	1.73
177	11	MA0661.1	MEOX1	MA0661.1	VSTAATTAHC	MEOX1	3.17e-220	7.13e-223	25200	86.3	22100	76	1.14
178	24	MA0077.1	SOX9	MA0077.1	CYATTGTTY	SOX9	3.71e-220	8.3e-223	22900	78.4	19400	66.6	1.18
179	14	MA0042.2	FOXI1	MA0042.2	GTAAACA	FOXI1	8.2e-220	1.82e-222	25500	87.2	22500	77.2	1.13
180	11	MA0880.1	Dlx3	MA0880.1	NYAATTAN	Dlx3	5.42e-219	1.2e-221	16400	56.1	12500	43	1.31
181	11	MA0634.1	ALX3	MA0634.1	YYYAATTANV	ALX3	1.03e-217	2.27e-220	24700	84.3	21400	73.6	1.14
182	17	MA0780.1	PAX3	MA0780.1	TAATYRATTA	PAX3	4.13e-217	9.02999999999999e-220	9870	33.7	6400	22	1.53
183	11	MA0644.2	ESX1	MA0644.2	YYAATTAN	ESX1	6.66e-217	1.45e-219	21100	72.2	17400	59.8	1.21
184	24	MA0078.2	Sox17	MA0078.2	NNAGAACAATGGNN	Sox17	8.35e-215	1.81e-217	21500	73.4	17800	61.2	1.2
185	11	MA0890.1	GBX2	MA0890.1	RSYAATTARN	GBX2	9.25999999999999e-215	1.99e-217	25800	88.1	22800	78.4	1.12
186	11	MA0881.1	Dlx4	MA0881.1	VYAATTAN	Dlx4	9.97e-215	2.13e-217	22200	75.9	18600	64	1.19
187	36	MA0052.4 (MEF2A)	MEME-4	WWYTAWAAATA	WWYTAWAAATA	MEF2A	1.01e-214	2.15e-217	12700	43.4	8970	30.8	1.41
188	11	MA0724.1	VENTX	MA0724.1	AMCGATTAR	VENTX	1.29e-214	2.72e-217	18800	64.4	15000	51.6	1.25
189	11	MA1476.2	Dlx5	MA1476.2	NDGCAATTAGNN	Dlx5	1.38e-214	2.91e-217	23800	81.4	20500	70.3	1.16
190	11	MA0874.1	Arx	MA0874.1	VTBCRYTAATTARTKSW	Arx	5.77e-213	1.21e-215	12900	44.2	9190	31.6	1.4
191	11	MA0876.1	BSX	MA0876.1	SYVATTAV	BSX	7.35e-212	1.53e-214	23000	78.5	19500	67	1.17
192	24	MA0867.2	SOX4	MA0867.2	RAACAAAGRV	SOX4	1.31e-211	2.71e-214	15200	51.8	11300	39	1.33
193	20	MA0838.1	CEBPG	MA0838.1	ATTRCGCAAY	CEBPG	3.26e-211	6.73e-214	12400	42.3	8690	29.9	1.41
194	11	MA0648.1	GSC	MA0648.1	VYTAATCCSY	GSC	1.85e-210	3.8e-213	26100	89.4	23300	80.2	1.11
195	11	MA0630.1	SHOX	MA0630.1	HTAATTRR	SHOX	7.4e-210	1.51e-212	26800	91.6	24200	83	1.1
196	11	MA0885.2	Dlx2	MA0885.2	NDGCAATTAGNN	Dlx2	6.77e-209	1.37e-211	23800	81.3	20400	70.3	1.16
197	13	MA0754.2	CUX1	MA0754.2	TAATCGATAM	CUX1	1.79e-208	3.61e-211	17600	60.2	13800	47.4	1.27
198	11	MA1497.1	HOXA6	MA1497.1	BGYMATTANN	HOXA6	3.04e-208	6.11e-211	22800	77.8	19300	66.3	1.17
199	4	MA0854.1	Alx1	MA0854.1	CGMRYTAATTARTNMNY	Alx1	3.25e-208	6.51e-211	15100	51.5	11300	38.7	1.33
200	26	MA0907.1	HOXC13	MA0907.1	BCTCGTAAAAH	HOXC13	3.76e-208	7.49e-211	15800	54	12000	41.2	1.31
201	11	MA0891.1	GSC2	MA0891.1	NYTAATCCBH	GSC2	1.68e-207	3.32e-210	23700	81.1	20400	70.2	1.16
202	4	MA0853.1	Alx4	MA0853.1	CGCRYTAATTARYHNNY	Alx4	2.46e-207	4.86e-210	16400	55.9	12500	43.1	1.3
203	30	MA0772.1	IRF7	MA0772.1	HCGAAARYGAAAVT	IRF7	1.21e-206	2.38e-209	11600	39.7	8030	27.6	1.44
204	34	MA1104.2	GATA6	MA1104.2	HWWTCTTATCTNH	GATA6	7.69e-205	1.5e-207	27000	92.2	24500	84.1	1.1
205	11	MA0894.1	HESX1	MA0894.1	GHTAATTRRH	HESX1	5.11e-204	9.93e-207	21400	73.2	17800	61.3	1.19
206	37	MA0898.1	Hmx3	MA0898.1	ASAAGCAATTAAWRRAT	Hmx3	6.04e-204	1.17e-206	20100	68.7	16400	56.4	1.22
207	11	MA0875.1	BARX1	MA0875.1	VCMATTAV	BARX1	1.16e-203	2.24e-206	14400	49.4	10700	36.8	1.34
208	14	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	4.89e-203	9.35e-206	25500	87.3	22600	77.7	1.12
209	19	MA0442.2	SOX10	MA0442.2	NDAACAAAGVN	SOX10	3.28e-202	6.25e-205	18400	63	14700	50.4	1.25
210	24	MA1120.1	SOX13	MA1120.1	DVACAATGGNN	SOX13	1.78e-200	3.37e-203	17600	60.1	13800	47.5	1.26
211	15	MA0878.3	CDX1	MA0878.3	GGYMATAAAA	CDX1	2.57e-200	4.86e-203	15700	53.6	12000	41.1	1.31
212	26	MA0906.1	HOXC12	MA0906.1	RGTCGTAAAAH	HOXC12	8.65999999999999e-200	1.63e-202	12900	44.3	9320	32.1	1.38
213	14	MA0480.2	Foxo1	MA0480.2	NDGTAAACANN	Foxo1	3.37e-199	6.29e-202	23500	80.2	20200	69.3	1.16
214	11	MA0709.1	Msx3	MA0709.1	SCAATTAN	Msx3	1.35e-198	2.5e-201	21800	74.4	18200	62.7	1.19
215	11	MA1499.1	HOXB4	MA1499.1	RTMATTAR	HOXB4	3.12e-196	5.78e-199	17300	59.2	13600	46.8	1.27
216	11	MA0712.2	OTX2	MA0712.2	NDRGGATTARNN	OTX2	1.76e-194	3.25e-197	26800	91.7	24300	83.6	1.1
217	11	MA1495.1	HOXA1	MA1495.1	STAATTAS	HOXA1	4.77e-194	8.75e-197	12900	44.1	9320	32.1	1.37
218	11	MA0889.1	GBX1	MA0889.1	VCYAATTASY	GBX1	3.94e-191	7.2e-194	20700	70.7	17200	59	1.2
219	11	MA1504.1	HOXC4	MA1504.1	VTMATTAN	HOXC4	5.27e-191	9.57e-194	17600	60.2	13900	48	1.26
220	30	MA1952.1	FOXJ2::ELF1	MA1952.1	RTAAACMGGAAGTR	FOXJ2::ELF1	7.28e-191	1.32e-193	23200	79.3	19900	68.6	1.16
221	11	MA0707.2	MNX1	MA0707.2	VYRATTAK	MNX1	1.01e-190	1.82e-193	17000	58	13300	45.8	1.27
222	4	MA0135.1	Lhx3	MA0135.1	WAATTAATTAWYY	Lhx3	2.01e-190	3.6e-193	7850	26.8	4860	16.7	1.6
223	11	MA1530.1	NKX6-3	MA1530.1	VYCATTAWW	NKX6-3	6.27e-190	1.12e-192	14600	50	11000	37.9	1.32
224	14	MA0849.1	FOXO6	MA0849.1	GTAAACA	FOXO6	9.85e-190	1.75e-192	20900	71.5	17400	59.9	1.19
225	14	MA0614.1	Foxj2	MA0614.1	RTAAACAA	Foxj2	6.79e-188	1.2e-190	18500	63.2	14900	51.2	1.24
226	11	MA1496.1	HOXA4	MA1496.1	RTMATTAV	HOXA4	2.02e-187	3.55e-190	19000	65	15400	53.1	1.23
227	6	MA1126.1	FOS::JUN	MA1126.1	DRTGACGTCATHNDTN	FOS::JUN	3.57e-187	6.26e-190	24300	83	21200	73	1.14
228	38	MA0152.2 (Nfatc2)	STREME-24	24-AAAAGGAAA	24-AAAAGGAAA	Nfatc2	6.08e-187	1.06e-189	17600	60.1	14000	48	1.25
229	11	MA0879.2	DLX1	MA0879.2	VYAATTAN	DLX1	6.98e-187	1.21e-189	25200	86	22300	76.5	1.12
230	39	MA1974.1	ZNF211	MA1974.1	HWYATATACCAYRYW	ZNF211	6.12e-186	1.06e-188	16500	56.5	12900	44.4	1.27
231	37	MA0897.1	Hmx2	MA0897.1	ASAAGCAATTAAHVVRT	Hmx2	1.8e-184	3.1e-187	19500	66.6	15900	54.8	1.22
232	11	MA1577.1	TLX2	MA1577.1	BYAATTAR	TLX2	1.16e-182	2e-185	12600	43	9130	31.4	1.37
233	34	MA1970.1	TRPS1	MA1970.1	NHTCTTATCTNH	TRPS1	2.24e-182	3.83e-185	26000	88.8	23300	80.2	1.11
234	40	MA1479.1	DMRTC2	MA1479.1	AATTGMTACATT	DMRTC2	1.08e-181	1.84e-184	21000	71.7	17600	60.4	1.19
235	24	MA0514.2	Sox3	MA0514.2	DNACAATGGNN	Sox3	1.41e-181	2.39e-184	16000	54.8	12500	42.9	1.28
236	41	MA0520.1	Stat6	MA0520.1	BDBTTCCWSAGAAVY	Stat6	3.63e-181	6.12e-184	11700	40	8330	28.6	1.4
237	42	MA1562.1	SOX14	MA1562.1	CCGAACAATG	SOX14	3.79e-181	6.37e-184	21100	72.2	17700	61	1.18
238	30	MA0152.2	Nfatc2	MA0152.2	NNRNAATGGAAANWNH	Nfatc2	5.01e-181	8.38e-184	21700	74.3	18400	63.2	1.18
239	43	MA0144.2	STAT3	MA0144.2	YTTCYKGGAAD	STAT3	3.53e-180	5.87e-183	21000	71.7	17600	60.4	1.19
240	44	MA0687.1	SPIC	MA0687.1	HAAAAGVGGAAGTA	SPIC	3.54e-180	5.88e-183	22900	78.3	19700	67.7	1.16
241	11	MA0618.1	LBX1	MA0618.1	TTAATTAG	LBX1	7.59e-180	1.25e-182	16500	56.4	12900	44.5	1.27
242	11	MA0904.2	HOXB5	MA0904.2	STAATTAS	HOXB5	3.14e-178	5.16e-181	12200	41.7	8820	30.3	1.38
243	30	MA0517.1	STAT1::STAT2	MA0517.1	THAGTTTCRKTTTCY	STAT1::STAT2	4.59e-178	7.52e-181	17300	59	13700	47.1	1.25
244	11	MA0912.2	HOXD3	MA0912.2	CTAATTAC	HOXD3	8.6e-178	1.4e-180	13300	45.4	9850	33.9	1.34
245	26	MA0594.2	HOXA9	MA0594.2	RTCGTWAHNN	HOXA9	7.89e-177	1.28e-179	21800	74.5	18500	63.6	1.17
246	11	MA1500.1	HOXB6	MA1500.1	BTAATKRC	HOXB6	4.99e-176	8.08e-179	19200	65.6	15700	54	1.21
247	14	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	5.51e-176	8.88e-179	26100	89.1	23500	80.7	1.1
248	45	MA0523.1	TCF7L2	MA0523.1	DRASATCAAAGRVA	TCF7L2	1.01e-175	1.62e-178	22000	75.1	18700	64.3	1.17
249	14	MA0593.1	FOXP2	MA0593.1	RWGTAAACAVR	FOXP2	1.82e-174	2.91e-177	9280	31.7	6220	21.4	1.48
250	37	MA0151.1	Arid3a	MA0151.1	ATYAAA	Arid3a	7.66e-173	1.22e-175	15700	53.6	12200	41.9	1.28
251	11	MA0642.2	EN2	MA0642.2	VSYAATTA	EN2	4.86e-171	7.7e-174	15000	51.4	11600	39.8	1.29
252	14	MA0850.1	FOXP3	MA0850.1	RTAAACA	FOXP3	6.45e-170	1.02e-172	24100	82.4	21200	72.7	1.13
253	11	MA1608.1	Isl1	MA1608.1	NNCCATTAGNN	Isl1	1.21e-169	1.9e-172	22600	77.3	19500	66.9	1.16
254	11	MA0699.1	LBX2	MA0699.1	NCYAATTARN	LBX2	1.24e-169	1.94e-172	26600	90.9	24200	83.2	1.09
255	37	MA0122.3	Nkx3-2	MA0122.3	WWAAMCACTTAAN	Nkx3-2	9.75e-168	1.52e-170	25300	86.6	22600	77.8	1.11
256	46	MA0629.1	Rhox11	MA0629.1	ANKNCGCTGTWAWDVRW	Rhox11	4.11e-167	6.38e-170	25300	86.6	22600	77.8	1.11
257	26	MA0873.1	HOXD12	MA0873.1	RGTCGTAAAAH	HOXD12	2.57e-166	3.97e-169	11600	39.7	8380	28.8	1.38
258	34	MA0036.3	GATA2	MA0036.3	NBCTTATCTNH	GATA2	5.77e-166	8.91e-169	24900	85.3	22200	76.3	1.12
259	11	MA0900.2	HOXA2	MA0900.2	STAATTAS	HOXA2	1.11e-165	1.71e-168	12200	41.8	8950	30.8	1.36
260	34	MA0037.4	Gata3	MA0037.4	NHTCTTATCTNH	Gata3	1.05e-164	1.61e-167	25400	86.7	22700	78.1	1.11
261	11	MA0893.2	GSX2	MA0893.2	SYMATTAR	GSX2	2e-164	3.05e-167	18300	62.5	14900	51.2	1.22
262	11	MA1519.1	LHX5	MA1519.1	STAATTAV	LHX5	5.71e-163	8.68e-166	14800	50.6	11400	39.3	1.29
263	45	MA0768.2	Lef1	MA0768.2	NNBCCTTTGATSTN	Lef1	3.02e-162	4.56e-165	20100	68.6	16800	57.7	1.19
264	11	MA1507.1	HOXD4	MA1507.1	VTMATTAD	HOXD4	3.25e-161	4.9e-164	12000	41.2	8820	30.4	1.36
265	11	MA0701.2	LHX9	MA0701.2	CYAATTAR	LHX9	3.32e-161	4.98e-164	11100	37.8	7930	27.3	1.39
266	47	MA0069.1	PAX6	MA0069.1	TTCACGCWTSANTK	PAX6	1.11e-160	1.66e-163	24600	84.2	21800	75.1	1.12
267	48	MA0877.3	BARHL1	MA0877.3	AMCGTTTA	BARHL1	1.4e-160	2.08e-163	26300	89.8	23800	81.9	1.1
268	45	MA0769.2	TCF7	MA0769.2	NNCTTTGAWVT	TCF7	1.39e-156	2.06e-159	25600	87.7	23100	79.4	1.1
269	23	MA0884.2	DUXA	MA0884.2	YTRATTWAATYAR	DUXA	1.56e-155	2.3e-158	6110	20.9	3670	12.6	1.65
270	34	MA0482.2	GATA4	MA0482.2	NNCCTTATCTNH	GATA4	3.37e-153	4.97e-156	26400	90.3	24100	82.8	1.09
271	11	MA0666.2	MSX1	MA0666.2	SCAATTAR	MSX1	8.4e-149	1.23e-151	22900	78.4	20000	68.9	1.14
272	6	MA0843.1	TEF	MA0843.1	BRTTACRTAAYM	TEF	4.2e-148	6.14e-151	10500	35.8	7500	25.8	1.39
273	11	MA0621.1	mix-a	MA0621.1	NDTTAATTAGN	mix-a	2e-147	2.92e-150	7860	26.9	5200	17.9	1.5
274	35	MA0714.1	PITX3	MA0714.1	NYTAATCCC	PITX3	3.64e-146	5.28e-149	26400	90.1	24100	82.8	1.09
275	49	MA1588.1	ZNF136	MA1588.1	RWATTCTTGGTTGRC	ZNF136	1.26e-145	1.83e-148	16400	55.9	13100	45.2	1.24
276	11	MA0708.2	MSX2	MA0708.2	SCAATTAV	MSX2	2.3e-145	3.31e-148	18600	63.5	15400	52.9	1.2
277	11	MA0467.2	Crx	MA0467.2	NDGGATTANN	Crx	4.04e-145	5.81e-148	20200	68.9	17100	58.6	1.18
278	14	MA0030.1	FOXF2	MA0030.1	BNAASGTAAACAAD	FOXF2	6.48e-145	9.28e-148	7380	25.2	4810	16.5	1.53
279	50	MA1119.1	SIX2	MA1119.1	NNCTGAAACCTGATMY	SIX2	1.26e-143	1.79e-146	19400	66.4	16300	56.1	1.19
280	51	25-GTATAV	STREME-25	25-GTATAV	25-GTATAV	GTATAV	5.7e-140	8.11e-143	18300	62.5	15100	52.1	1.2
281	50	MA1118.1	SIX1	MA1118.1	GWAACCTGAKM	SIX1	9.75e-138	1.38e-140	19800	67.8	16800	57.8	1.17
282	31	MA0624.2	Nfatc1	MA0624.2	NVATGGAAAAWN	Nfatc1	1.2e-135	1.69e-138	19600	67.1	16600	57	1.18
283	35	MA0711.1	OTX1	MA0711.1	HTAATCCS	OTX1	6.92e-135	9.73e-138	26000	88.8	23700	81.5	1.09
284	11	MA0705.1	Lhx8	MA0705.1	CTAATTAV	Lhx8	3.86e-131	5.42e-134	15400	52.5	12300	42.3	1.24
285	35	MA0883.1	Dmbx1	MA0883.1	WDRWNMGGATTADKNNW	Dmbx1	5.71e-129	7.97e-132	16300	55.8	13300	45.7	1.22
286	24	MA0515.1	Sox6	MA0515.1	CCWTTGTYYY	Sox6	9.11e-127	1.27e-129	8840	30.2	6240	21.4	1.41
287	37	MA0896.1	Hmx1	MA0896.1	VSVAGCAATTAAWGVDB	Hmx1	5.86e-126	8.13e-129	19500	66.8	16600	57.1	1.17
288	6	MA0639.1	DBP	MA0639.1	NRTTACGTAAYV	DBP	1.38e-125	1.91e-128	9160	31.3	6540	22.5	1.39
289	24	MA0869.2	Sox11	MA0869.2	NRGAACAAAGVV	Sox11	2.56e-123	3.52e-126	20700	70.8	17900	61.4	1.15
290	24	MA0087.2	Sox5	MA0087.2	VRVAACAATGGNN	Sox5	8.06e-123	1.11e-125	19200	65.6	16300	56	1.17
291	52	MA0678.1	OLIG2	MA0678.1	AMCATATGKT	OLIG2	8.15e-123	1.11e-125	19000	64.9	16100	55.2	1.17
292	37	MA0914.1	ISL2	MA0914.1	GCAMTTAR	ISL2	5.15e-120	7.02e-123	26300	89.8	24200	83.2	1.08
293	45	MA1991.1	Hnf1A	MA1991.1	NBCCTTTGATSTBN	Hnf1A	2.55e-119	3.47e-122	22400	76.6	19800	68	1.13
294	24	MA1563.2	SOX18	MA1563.2	AACAATDV	SOX18	1.11e-118	1.5e-121	19200	65.5	16300	56	1.17
295	27	MA0117.2	Mafb	MA0117.2	AWWNTGCTGACD	Mafb	3.83e-114	5.16e-117	24500	83.9	22200	76.3	1.1
296	6	MA1150.1	RORB	MA1150.1	AWWTRGGTCAH	RORB	4.48e-114	6.02e-117	20800	71.2	18100	62.2	1.14
297	53	MA0693.3	Vdr	MA0693.3	NNGAGTTCANN	Vdr	2.36e-113	3.16e-116	25400	86.9	23200	79.9	1.09
298	27	MA1520.1	MAF	MA1520.1	NTGCTGASTCAGCAH	MAF	5.04e-112	6.73e-115	24500	83.6	22100	76	1.1
299	11	MA0702.2	LMX1A	MA0702.2	TTAATTAM	LMX1A	1.22e-111	1.63e-114	9340	31.9	6830	23.5	1.36
300	54	MA0095.3	Yy1	MA0095.3	NNCAAAATGGCN	Yy1	5.55e-111	7.36e-114	15800	54	13000	44.7	1.21
301	26	MA1506.1	HOXD10	MA1506.1	RGTCGTAAAAH	HOXD10	1.81e-110	2.39e-113	8300	28.4	5920	20.4	1.39
302	20	MA0837.2	CEBPE	MA0837.2	KATTGCGCAATM	CEBPE	6.44e-106	8.49e-109	3920	13.4	2270	7.8	1.72
303	6	MA1127.1	FOSB::JUN	MA1127.1	GATGACGTCAT	FOSB::JUN	1.29e-105	1.7e-108	23700	80.8	21300	73.2	1.11
304	6	MA1131.1	FOSL2::JUN	MA1131.1	GRTGACGTMAT	FOSL2::JUN	4.21e-105	5.51e-108	22800	77.8	20300	69.8	1.11
305	11	MA1501.1	HOXB7	MA1501.1	GGTAATTAVS	HOXB7	4.67e-105	6.1e-108	16700	57	13900	47.9	1.19
306	41	MA1625.1	Stat5b	MA1625.1	NNNTTCCCAGAANNN	Stat5b	7.1e-105	9.24e-108	22800	77.8	20300	69.8	1.11
307	37	MA0070.1	PBX1	MA0070.1	HCATCAATCAAW	PBX1	2.76e-104	3.57e-107	14400	49.2	11700	40.2	1.22
308	40	MA1707.1	DMRTA1	MA1707.1	AWTTGWTACAWT	DMRTA1	3.3e-101	4.27e-104	18700	63.8	16000	55	1.16
309	55	MA0619.1	LIN54	MA0619.1	DTTTRAATH	LIN54	4.46e-101	5.75e-104	6600	22.6	4520	15.5	1.45
310	42	MA1561.1	SOX12	MA1561.1	ACCGAACAATV	SOX12	2.09e-98	2.68e-101	20100	68.8	17600	60.4	1.14
311	26	MA1503.1	HOXB9	MA1503.1	GTCGTAAAAH	HOXB9	3.3e-98	4.23e-101	5330	18.2	3470	11.9	1.53
312	56	MA0114.4 (HNF4A)	STREME-23	23-AAGTCCAW	23-AAGTCCAW	HNF4A	2.09e-94	2.67e-97	17500	59.8	14900	51.2	1.17
313	41	MA0518.1	Stat4	MA0518.1	YTTCYRGGAARNVR	Stat4	2.71e-94	3.44e-97	15900	54.3	13300	45.6	1.19
314	40	MA1478.1	DMRTA2	MA1478.1	AATTGHTACAWT	DMRTA2	2.39e-93	3.04e-96	17300	59.2	14700	50.6	1.17
315	23	MA0468.1	DUX4	MA0468.1	TAAYYYAATCA	DUX4	3.89e-92	4.92e-95	6500	22.2	4520	15.5	1.43
316	6	MA1145.1	FOSL2::JUND	MA1145.1	NNRTGACGTCAYHSN	FOSL2::JUND	5.05e-89	6.36e-92	21400	73.2	19000	65.4	1.12
317	6	MA1139.1	FOSL2::JUNB	MA1139.1	DATGACGTCATH	FOSL2::JUNB	7.47e-89	9.38e-92	18400	62.9	15900	54.6	1.15
318	26	MA0651.2	HOXC11	MA0651.2	AGGTCGTAAAAH	HOXC11	1.45e-87	1.81e-90	5380	18.4	3600	12.4	1.48
319	72	MA0106.3	TP53	MA0106.3	RACATGYCCGGRCATGTY	TP53	1.85e-86	2.3e-89	1780	6.07	788	2.71	2.24
320	6	MA1129.1	FOSL1::JUN	MA1129.1	ATGACGTCAT	FOSL1::JUN	5.82e-85	7.24e-88	20300	69.3	17900	61.5	1.13
321	57	MA1960.1	MGA::EVX1	MA1960.1	RGGTGWTAATKD	MGA::EVX1	6.76e-85	8.38e-88	22200	76	20000	68.7	1.11
322	58	MA1989.1	Bcl11B	MA1989.1	NNAAACCACAARNN	Bcl11B	3.61e-82	4.46e-85	26700	91.4	25100	86.3	1.06
323	52	MA0827.1	OLIG3	MA0827.1	AMCATATGBY	OLIG3	3.9e-82	4.8e-85	21900	74.7	19600	67.4	1.11
324	37	MA0063.2	NKX2-5	MA0063.2	NNCACTCAANN	NKX2-5	2.36e-81	2.9e-84	27300	93.5	25900	88.9	1.05
325	59	MA1105.2	GRHL2	MA1105.2	NRAACAGGTTYN	GRHL2	3.83e-79	4.7e-82	18100	61.8	15700	54	1.14
326	60	MA1975.1	ZNF214	MA1975.1	VWTCATCAABGTCCT	ZNF214	7.12e-79	8.69e-82	24900	85	23000	79	1.08
327	61	MA0483.1	Gfi1B	MA0483.1	AAATCWCWGCH	Gfi1B	1.28e-78	1.56e-81	16900	57.7	14500	49.8	1.16
328	43	MA1624.1	Stat5a	MA1624.1	NTTCCAAGAANH	Stat5a	3.79e-78	4.6e-81	19700	67.3	17400	59.7	1.13
329	45	MA1421.1	TCF7L1	MA1421.1	AAAGATCAAAGG	TCF7L1	3.26e-76	3.94e-79	12800	43.9	10500	36.2	1.21
330	15	MA1473.1	CDX4	MA1473.1	GGYMATAAAAC	CDX4	3.73e-76	4.5e-79	4680	16	3120	10.7	1.49
331	30	MA1953.1	FOXO1::ELF1	MA1953.1	RTMAACAGGAAGTN	FOXO1::ELF1	1.28e-75	1.53e-78	26400	90.2	24800	85.2	1.06
332	6	MA1632.1	ATF2	MA1632.1	NNATGABGTCATN	ATF2	1.62e-75	1.95e-78	21000	71.6	18700	64.4	1.11
333	6	MA1133.1	JUN::JUNB	MA1133.1	KRTGACGTCATN	JUN::JUNB	1.92e-74	2.3e-77	22800	78.1	20800	71.4	1.09
334	43	MA0463.2	BCL6	MA0463.2	NYGCTTTCKAGGAAYN	BCL6	9e-74	1.07e-76	18300	62.6	16000	55	1.14
335	50	MA2001.1	Six4	MA2001.1	GDAACCTGANH	Six4	3.26e-71	3.87e-74	14800	50.6	12500	43.1	1.17
336	44	MA0508.3	PRDM1	MA0508.3	YNCTTTCTCTH	PRDM1	5.72e-71	6.78e-74	27300	93.2	25900	88.9	1.05
337	62	MA1714.1	ZNF675	MA1714.1	RGGVHYMGGAGGMCAAAATGD	ZNF675	1.33e-70	1.57e-73	18500	63.1	16200	55.7	1.13
338	63	MA0809.2	TEAD4	MA0809.2	NNACATTCCARN	TEAD4	9.68e-69	1.14e-71	27400	93.6	26000	89.4	1.05
339	6	MA0018.4	CREB1	MA0018.4	NNRTGATGTCAYN	CREB1	2.78e-68	3.27e-71	24400	83.4	22500	77.5	1.08
340	30	MA1956.1	FOXO1::FLI1	MA1956.1	GTAAACAGGAAGTK	FOXO1::FLI1	3.3e-68	3.87e-71	6460	22.1	4740	16.3	1.36
341	10	MA0784.2	POU1F1	MA0784.2	ANCTMATTWGCATAWT	POU1F1	8.29e-68	9.68e-71	3190	10.9	1970	6.76	1.61
342	20	MA0466.3	CEBPB	MA0466.3	KATTGCGCAATM	CEBPB	9.09e-67	1.06e-69	2150	7.36	1160	4.01	1.84
343	23	MA1720.1	ZNF85	MA1720.1	DHDGAGATTACWKCAK	ZNF85	2.78e-66	3.23e-69	20700	70.7	18600	63.8	1.11
344	64	MA1592.1	ZNF274	MA1592.1	NRTRTGAGTTCTCGYN	ZNF274	2.79e-66	3.23e-69	7070	24.2	5300	18.2	1.33
345	43	MA0137.3	STAT1	MA0137.3	TTTCYRGGAAA	STAT1	9.63e-66	1.11e-68	14600	50	12400	42.7	1.17
346	53	MA1534.1	NR1I3	MA1534.1	RTGAACTTT	NR1I3	1.86e-65	2.14e-68	20000	68.4	17900	61.5	1.11
347	63	MA0090.3	TEAD1	MA0090.3	NNACATTCCAGSN	TEAD1	8.14e-65	9.34e-68	26100	89.4	24600	84.5	1.06
348	37	MA1994.1	Nkx2-1	MA1994.1	NVCACTTGARHNN	Nkx2-1	4.09e-64	4.67e-67	27000	92.4	25700	88.2	1.05
349	65	MA1937.1	ERF::HOXB13	MA1937.1	VSCGGAARYNRTWAAN	ERF::HOXB13	7.29e-64	8.31e-67	20200	68.9	18100	62.1	1.11
350	6	MA1136.1	FOSB::JUNB	MA1136.1	RTGACGTCAT	FOSB::JUNB	2.56e-63	2.92e-66	26400	90.1	24900	85.5	1.05
351	44	MA1949.1	FLI1::DRGX	MA1949.1	ACCGGAAGTAATTAT	FLI1::DRGX	1.63e-62	1.85e-65	22400	76.5	20400	70.2	1.09
352	66	MA1980.1	ZNF418	MA1980.1	MDGAGGCTAAAAGCA	ZNF418	5.03e-62	5.68e-65	18100	62	16000	55.1	1.13
353	67	MA1151.1	RORC	MA1151.1	NWAWNTRGGTCA	RORC	5.57e-62	6.28e-65	17300	59.2	15200	52.2	1.13
354	68	MA1112.2	NR4A1	MA1112.2	NNAAAGGTCANN	NR4A1	4.66e-59	5.24e-62	19700	67.3	17700	60.8	1.11
355	59	MA0647.1	GRHL1	MA0647.1	AAAACCGGTTTD	GRHL1	6.54e-59	7.33e-62	11700	40	9700	33.4	1.2
356	69	MA1580.1	ZBTB32	MA1580.1	TGTACAGTAW	ZBTB32	6.65e-59	7.43e-62	7200	24.6	5520	19	1.3
357	70	MA1585.1	ZKSCAN1	MA1585.1	AYAGTAGGTS	ZKSCAN1	8.38e-59	9.34e-62	14400	49.3	12300	42.4	1.16
358	71	MA0479.1	FOXH1	MA0479.1	BNSAATCCACA	FOXH1	3.16e-58	3.52e-61	6440	22	4830	16.6	1.32
359	27	MA1521.1	MAFA	MA1521.1	NTGCTGASTCAGCAN	MAFA	7.31e-58	8.11e-61	2160	7.39	1230	4.23	1.75
360	67	MA0494.1	Nr1h3::Rxra	MA0494.1	TGACCTNNAGTRACCYYDN	Nr1h3::Rxra	1.42e-55	1.57e-58	24700	84.6	23100	79.4	1.06
361	72	MA0106.3 (TP53)	STREME-8	8-RGRCATGYCY	RGRCATGYCY	TP53	2.26e-55	2.49e-58	1260	4.32	585	2.01	2.14
362	72	MA0861.1	TP73	MA0861.1	DRCATGTCNNRACAYGYM	TP73	2.53e-55	2.78e-58	709	2.42	229	0.79	3.07
363	73	MA1596.1 (ZNF460)	STREME-9	9-CCTCAGCCTCCCAAR	CCTCAGCCTCCCAAR	ZNF460	4.76e-55	5.22e-58	823	2.81	298	1.02	2.74
364	27	MA0842.2	NRL	MA0842.2	AAWWNTGCTGACG	NRL	1.13e-54	1.24e-57	10000	34.3	8200	28.2	1.22
365	67	MA1148.1	PPARA::RXRA	MA1148.1	AWNTRGGTYAAAGGTCAN	PPARA::RXRA	3.71e-53	4.05e-56	25200	86.2	23700	81.4	1.06
366	74	MA0631.1	Six3	MA0631.1	DATRGGGTATCAYNWNT	Six3	7.57e-53	8.23e-56	14100	48.1	12100	41.7	1.16
367	53	MA1111.1	NR2F2	MA1111.1	NAAAGGTCANR	NR2F2	4.4e-52	4.77e-55	25800	88	24300	83.5	1.05
368	58	MA0684.2	RUNX3	MA0684.2	NHAACCTCAANN	RUNX3	1.84e-51	1.99e-54	26000	88.9	24600	84.5	1.05
369	75	MA1995.1	Npas4	MA1995.1	NNTCGTGACHN	Npas4	3.44e-50	3.71e-53	22800	77.8	21000	72.3	1.08
370	76	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	1.26e-49	1.35e-52	21700	74.1	19900	68.4	1.08
371	61	MA0038.2	GFI1	MA0038.2	BMAATCACDGCA	GFI1	1.74e-48	1.87e-51	7390	25.3	5830	20	1.26
372	26	MA0485.2	HOXC9	MA0485.2	GTCGTAAAAH	HOXC9	3.58e-48	3.84e-51	3260	11.2	2200	7.55	1.48
373	39	MA1718.1	ZNF8	MA1718.1	GTATGGATATACCACAKTTT	ZNF8	5.75e-48	6.13e-51	2990	10.2	1970	6.77	1.51
374	77	MA0620.3	MITF	MA0620.3	NNNDRTCACGTGAYHNNN	MITF	2.22e-47	2.36e-50	13900	47.5	12000	41.4	1.15
375	30	MA1955.1	FOXO1::ELK3	MA1955.1	RWMAACAGGAAGTN	FOXO1::ELK3	2.37e-46	2.51e-49	17800	60.9	16000	54.9	1.11
376	78	MA0029.1	Mecom	MA0029.1	AAGAYAAGATAANA	Mecom	8.21e-45	8.69e-48	4990	17.1	3720	12.8	1.33
377	52	MA1108.2	MXI1	MA1108.2	NNCACATGBN	MXI1	1.55e-44	1.64e-47	22500	76.9	20900	71.7	1.07
378	30	MA1950.1	FLI1::FOXI1	MA1950.1	RTAAACAGGAARYN	FLI1::FOXI1	4.1e-44	4.31e-47	25700	87.8	24300	83.7	1.05
379	43	MA0519.1	Stat5a::Stat5b	MA0519.1	DTTTCCMAGAA	Stat5a::Stat5b	2e-43	2.1e-46	14600	49.8	12800	44	1.13
380	30	MA1420.1	IRF5	MA1420.1	CCGAAACCGAAACY	IRF5	4.09e-43	4.28e-46	18500	63.3	16700	57.6	1.1
381	30	MA1508.1	IKZF1	MA1508.1	VVAACAGGAARN	IKZF1	4.13e-43	4.31e-46	21600	74	20000	68.6	1.08
382	36	MA0773.1	MEF2D	MA0773.1	DCTAWAAATAGM	MEF2D	4.82e-43	5.03e-46	4720	16.1	3500	12	1.34
383	79	MA0525.2	TP63	MA0525.2	RACATGTYGKGACATGTC	TP63	4.12e-42	4.28e-45	452	1.54	124	0.43	3.6
384	80	MA0689.1	TBX20	MA0689.1	WAGGTGTGAAR	TBX20	4.25e-41	4.41e-44	22900	78.2	21300	73.2	1.07
385	10	MA0507.2	POU2F2	MA0507.2	AWTATGCAAATKAG	POU2F2	6.94e-40	7.17e-43	1860	6.34	1120	3.86	1.64
386	36	MA0660.1	MEF2B	MA0660.1	RCTAWAAATAGC	MEF2B	3.18e-39	3.28e-42	5040	17.2	3840	13.2	1.31
387	81	MA1523.1	MSANTD3	MA1523.1	STVCACTCAC	MSANTD3	9.24e-39	9.5e-42	26600	90.9	25400	87.4	1.04
388	52	MA0461.2	Atoh1	MA0461.2	RMCATATGBY	Atoh1	7.71e-38	7.91e-41	16400	56	14700	50.4	1.11
389	35	MA0719.1	RHOXF1	MA0719.1	NTRATCCN	RHOXF1	1.01e-37	1.04e-40	12000	40.9	10300	35.5	1.15
390	30	MA1947.1	ETV5::FOXO1	MA1947.1	GTMAACAGGAWRY	ETV5::FOXO1	3.85e-37	3.92e-40	26100	89.2	24900	85.6	1.04
391	59	MA0743.2	SCRT1	MA0743.2	NDWKCAACAGGTGKNN	SCRT1	1.08e-36	1.1e-39	15500	52.9	13800	47.4	1.11
392	82	MA0771.1	HSF4	MA0771.1	TTCTAGAABNTTC	HSF4	1.55e-36	1.57e-39	21100	72	19500	67	1.07
393	83	MA0682.2 (PITX1)	STREME-6	6-CCTGTAATCC	CCTGTAATCC	PITX1	3.61e-36	3.66e-39	1520	5.21	893	3.07	1.7
394	63	MA1121.1	TEAD2	MA1121.1	NYACATTCCWNNS	TEAD2	2.01e-35	2.03e-38	27900	95.5	27000	93	1.03
395	75	MA1546.1	PAX3	MA1546.1	YSGTCACGSYWATTAN	PAX3	4.85e-35	4.88e-38	17300	59	15600	53.8	1.1
396	56	MA0114.4	HNF4A	MA0114.4	DNCAAAGTCCANN	HNF4A	1.52e-34	1.53e-37	27200	92.8	26100	89.8	1.03
397	84	MA1515.1 (KLF2)	STREME-22	22-GCCACCACGCCCRGC	22-GCCACCACGCCCRGC	KLF2	2.35e-34	2.35e-37	744	2.54	332	1.14	2.22
398	6	MA0862.1	GMEB2	MA0862.1	TTACGTAA	GMEB2	6.72e-34	6.73e-37	22300	76.2	20800	71.6	1.06
399	85	MA1647.2	Prdm4	MA1647.2	RDNCCTTGAAACYGYYN	Prdm4	1.08e-33	1.08e-36	21900	74.9	20400	70.2	1.07
400	52	MA1524.2	Msgn1	MA1524.2	VRRRACAAATGGTNNN	Msgn1	3.68e-33	3.66e-36	17300	59.1	15700	54	1.09
401	13	MA0756.2	ONECUT2	MA0756.2	CGATCRATA	ONECUT2	4.71e-33	4.68e-36	7040	24.1	5760	19.8	1.22
402	59	MA0744.2	SCRT2	MA0744.2	NNWGCAACAGGTGDNN	SCRT2	5e-33	4.95e-36	25100	85.6	23800	81.8	1.05
403	86	MA1509.1	IRF6	MA1509.1	ACCGAAACT	IRF6	6.27e-33	6.2e-36	10600	36.1	9080	31.2	1.16
404	65	MA1943.1	ETV2::HOXB13	MA1943.1	ACCGGAAMYATWAAM	ETV2::HOXB13	7.45e-33	7.34e-36	7580	25.9	6260	21.5	1.2
405	87	MA0140.2	GATA1::TAL1	MA0140.2	MTTATCWSNNNNNHVCAG	GATA1::TAL1	2.37e-32	2.33e-35	10600	36.2	9130	31.4	1.15
406	88	10-GARACCCCRTCTC	STREME-10	10-GARACCCCRTCTC	10-GARACCCCRTCTC	GARACCCCRTCTC	6.96e-32	6.83e-35	703	2.4	316	1.09	2.21
407	30	MA1954.1	FOXO1::ELK1	MA1954.1	RWMAACAGGAAGTD	FOXO1::ELK1	1.05e-31	1.02e-34	21000	71.8	19500	67.1	1.07
408	52	MA0817.1	BHLHE23	MA0817.1	AAACATATGBTN	BHLHE23	1.64e-31	1.6e-34	2490	8.51	1720	5.91	1.44
409	11	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	2.96e-31	2.88e-34	24700	84.5	23500	80.6	1.05
410	40	MA0610.1	DMRT3	MA0610.1	MATGTATCAAN	DMRT3	5.14e-31	4.99e-34	7760	26.5	6460	22.2	1.19
411	30	MA0080.6	Spi1	MA0080.6	RRAAAGAGGAAGTGGDD	Spi1	5.11e-30	4.95e-33	22000	75.1	20600	70.8	1.06
412	35	MA1547.2	PITX2	MA1547.2	YTAATCCY	PITX2	9.24e-29	8.93e-32	4150	14.2	3200	11	1.29
413	73	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	1.14e-27	1.1e-30	533	1.82	222	0.76	2.38
414	31	MA1525.2	NFATC4	MA1525.2	AAYGGAAAMW	NFATC4	1.16e-27	1.11e-30	9030	30.9	7730	26.6	1.16
415	52	MA0826.1	OLIG1	MA0826.1	AMCATATGKT	OLIG1	1.56e-27	1.5e-30	8670	29.6	7390	25.4	1.17
416	58	MA0002.2	Runx1	MA0002.2	BBYTGTGGTTT	Runx1	2.15e-27	2.06e-30	2240	7.65	1550	5.33	1.44
417	77	MA0829.2	SREBF1	MA0829.2	DNATCACSTGATNH	SREBF1	2.96e-27	2.82e-30	5310	18.2	4270	14.7	1.24
418	44	MA1940.1	ETV2::DRGX	MA1940.1	RVCGGAAGYAATTA	ETV2::DRGX	6.3e-27	6e-30	11300	38.7	9940	34.2	1.13
419	56	MA0484.2	HNF4G	MA0484.2	DNCAAAGTCCANN	HNF4G	6.69e-27	6.35e-30	26400	90.2	25400	87.2	1.03
420	44	MA1942.1	ETV2::FOXI1	MA1942.1	BGTAAACAGGAAGYR	ETV2::FOXI1	1.46e-26	1.38e-29	20900	71.5	19500	67.2	1.06
421	89	MA1579.1	ZBTB26	MA1579.1	NNCTCCAGAAANNNN	ZBTB26	4.23e-26	4e-29	20100	68.7	18700	64.3	1.07
422	90	MA0101.1	REL	MA0101.1	BGGRNWTTCC	REL	3.75e-25	3.54e-28	27300	93.4	26500	91	1.03
423	6	MA0840.1	Creb5	MA0840.1	NATGACGTCAYH	Creb5	4.35e-25	4.09e-28	3080	10.5	2300	7.9	1.33
424	30	MA1418.1	IRF3	MA1418.1	NSRRAAMGGAAACCGAAACYR	IRF3	4.56e-25	4.28e-28	2420	8.26	1730	5.95	1.39
425	67	MA0072.1	RORA	MA0072.1	NWWAWBTAGGTCAR	RORA	1.21e-24	1.13e-27	2540	8.67	1840	6.32	1.37
426	52	MA1618.1	Ptf1a	MA1618.1	NNACAGATGTTNN	Ptf1a	2.79e-24	2.61e-27	12900	44	11500	39.6	1.11
427	91	16-AACTCCTGRSCTC	STREME-16	16-AACTCCTGRSCTC	16-AACTCCTGRSCTC	AACTCCTGRSCTC	4.46e-24	4.16e-27	474	1.62	199	0.68	2.36
428	37	MA0124.2	Nkx3-1	MA0124.2	RCCACTTAA	Nkx3-1	3.36e-23	3.13e-26	26500	90.5	25500	87.8	1.03
429	59	MA1968.1	TFCP2	MA1968.1	AAACCGGTTY	TFCP2	6.84e-23	6.35e-26	19800	67.8	18500	63.7	1.06
430	30	MA0653.1	IRF9	MA0653.1	AACGAAACCGAAACT	IRF9	1e-22	9.27e-26	489	1.67	215	0.74	2.25
431	58	MA0511.2	RUNX2	MA0511.2	WAACCGCAA	RUNX2	1.13e-22	1.04e-25	1900	6.49	1320	4.53	1.43
432	92	MA0794.1	PROX1	MA0794.1	YAAGACGYCTTA	PROX1	1.17e-22	1.08e-25	6380	21.8	5340	18.3	1.19
433	93	MA0019.1	Ddit3::Cebpa	MA0019.1	VNRTGCAATMCC	Ddit3::Cebpa	3.66e-22	3.36e-25	10300	35.2	9060	31.2	1.13
434	94	MA1973.1 (ZKSCAN3)	STREME-12	12-AGACCAGCCTGGGC	12-AGACCAGCCTGGGC	ZKSCAN3	4.44e-22	4.08e-25	789	2.7	432	1.49	1.81
435	76	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	6.09e-22	5.57e-25	24200	82.8	23100	79.4	1.04
436	95	17-CAGCTACTCRGGAG	STREME-17	17-CAGCTACTCRGGAG	17-CAGCTACTCRGGAG	CAGCTACTCRGGAG	1.56e-21	1.43e-24	293	1	96	0.33	3.01
437	96	MA1983.1	ZNF582	MA1983.1	TCTGTTACTTGCAGCCAAAWG	ZNF582	1.86e-21	1.7e-24	6120	20.9	5120	17.6	1.19
438	11	MA0703.2	LMX1B	MA0703.2	AWTTTAATTAA	LMX1B	1.91e-21	1.74e-24	1570	5.36	1060	3.63	1.48
439	97	MA0596.1	SREBF2	MA0596.1	RTGGGGTGAY	SREBF2	2.11e-21	1.92e-24	8480	29	7340	25.2	1.15
440	44	MA0598.3	EHF	MA0598.3	NNCACTTCCTGTTNN	EHF	8e-21	7.24e-24	24400	83.6	23400	80.4	1.04
441	44	MA0136.3	Elf5	MA0136.3	RVAAGGAAGTNN	Elf5	8.21e-21	7.41e-24	11300	38.7	10100	34.7	1.11
442	87	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	1.03e-19	9.27e-23	16400	56.1	15100	52	1.08
443	6	MA0488.1	JUN	MA0488.1	DDRATGATGTCAT	JUN	1.1e-19	9.9e-23	1520	5.19	1030	3.55	1.46
444	82	MA0486.2	HSF1	MA0486.2	TTCTAGAAYRTTC	HSF1	1.76e-18	1.58e-21	4300	14.7	3500	12	1.22
445	77	MA0093.3	USF1	MA0093.3	NDGTCATGTGACHN	USF1	1.37e-17	1.22e-20	10800	36.8	9630	33.1	1.11
446	98	13-AAGTGATCCDCC	STREME-13	13-AAGTGATCCDCC	13-AAGTGATCCDCC	AAGTGATCCDCC	1.46e-17	1.31e-20	345	1.18	143	0.49	2.39
447	99	21-AGGCTGCAGTGAGY	STREME-21	21-AGGCTGCAGTGAGY	21-AGGCTGCAGTGAGY	AGGCTGCAGTGAGY	8.14e-17	7.25e-20	394	1.35	179	0.62	2.18
448	44	MA0081.2	SPIB	MA0081.2	TYTCACTTCCTCTTTY	SPIB	9.36e-17	8.32e-20	22900	78.2	21800	75	1.04
449	53	MA1996.1	Nr1H2	MA1996.1	NNRAGGTCANN	Nr1H2	1.03e-16	9.15e-20	17900	61.1	16700	57.4	1.06
450	100	MA0164.1	Nr2e3	MA0164.1	CAAGCTT	Nr2e3	2.11e-16	1.87e-19	3970	13.6	3240	11.2	1.22
451	26	MA1958.1	HOXD12::ELK1	MA1958.1	DRVCGGAAGTCGTAAAD	HOXD12::ELK1	1.05e-15	9.27e-19	1720	5.89	1250	4.3	1.37
452	30	MA0652.1	IRF8	MA0652.1	HCGAAACCGAAACT	IRF8	2.98e-15	2.62e-18	437	1.49	217	0.75	2
453	101	MA1593.1	ZNF317	MA1593.1	WVACAGCAGAYW	ZNF317	4.73e-15	4.16e-18	16800	57.3	15600	53.8	1.07
454	30	MA1935.1	ERF::FOXI1	MA1935.1	RTAAACMGGAARTR	ERF::FOXI1	4.76e-15	4.17e-18	28100	96.2	27500	94.7	1.02
455	82	MA0770.1	HSF2	MA0770.1	TTCTAGAAYRTTC	HSF2	5.03e-15	4.4e-18	2980	10.2	2370	8.15	1.25
456	73	MA1587.1	ZNF135	MA1587.1	CCTCGACCTCCYRR	ZNF135	2.35e-14	2.05e-17	800	2.73	498	1.71	1.6
457	77	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	7.72e-14	6.72e-17	15300	52.2	14200	48.8	1.07
458	102	MA1616.1	Prdm15	MA1616.1	NRGAAAACCTGGAVN	Prdm15	2.43e-13	2.11e-16	18900	64.5	17800	61.2	1.05
459	30	MA1419.1	IRF4	MA1419.1	HCGAAACCGAAACYA	IRF4	2.57e-13	2.23e-16	479	1.64	259	0.89	1.84
460	103	MA1998.1	Prdm14	MA1998.1	NDGGTCTCTAWS	Prdm14	7.07e-13	6.12e-16	13100	44.9	12100	41.6	1.08
461	52	MA1123.2	TWIST1	MA1123.2	NNDCCAGATGTBN	TWIST1	3.16e-11	2.72e-14	11200	38.2	10200	35.2	1.09
462	68	MA1541.1	NR6A1	MA1541.1	NYCAAGKTCAAGKTCAN	NR6A1	3.43e-11	2.96e-14	10300	35	9340	32.1	1.09
463	53	MA1110.2	Nr1H4	MA1110.2	NVAGGTCANN	Nr1H4	4.17e-11	3.59e-14	26100	89.1	25300	87.1	1.02
464	104	MA0776.1	MYBL1	MA0776.1	ACCGTTAACSGY	MYBL1	4.37e-11	3.75e-14	7080	24.2	6280	21.6	1.12
465	30	MA0051.1	IRF2	MA0051.1	SGAAAGYGAAASCRWWWM	IRF2	5.38e-10	4.6e-13	381	1.3	208	0.72	1.82
466	105	MA1594.1	ZNF382	MA1594.1	AGGRGAYATCACYACMGAYCCCAC	ZNF382	5.98e-10	5.11e-13	2750	9.4	2260	7.75	1.21
467	106	MA0472.2 (EGR2)	STREME-19	19-ACACCCACACAC	19-ACACCCACACAC	EGR2	1.12e-09	9.54e-13	225	0.77	99	0.34	2.25
468	106	ACACACACACACACA	MEME-3	ACACACACACACACA	ACACACACACACACA	ACACACACACACACA	1.28e-09	1.09e-12	2340	8.02	1890	6.51	1.23
469	80	MA0800.1	EOMES	MA0800.1	RAGGTGTGAAAWN	EOMES	1.76e-09	1.49e-12	24000	82	23200	79.8	1.03
470	30	MA1946.1	ETV5::FOXI1	MA1946.1	GTAAACAGGAWGY	ETV5::FOXI1	1.73e-08	1.46e-11	5160	17.6	4540	15.6	1.13
471	6	MA0492.1	JUND	MA0492.1	DDDRATGABGTCATN	JUND	2.3e-08	1.95e-11	1360	4.67	1040	3.58	1.3
472	107	MA0698.1	ZBTB18	MA0698.1	NATCCAGATGTKB	ZBTB18	1.29e-07	1.08e-10	3200	10.9	2720	9.35	1.17
473	44	MA1944.1	ETV5::DRGX	MA1944.1	RSMGGAAGYAATTA	ETV5::DRGX	6.94e-07	5.84e-10	21600	73.7	20800	71.5	1.03
474	106	MA1493.1 (HES6)	STREME-15	15-ACACGTGCACACACA	15-ACACGTGCACACACA	HES6	1.62e-06	1.36e-09	209	0.71	104	0.36	1.99
475	52	MA0818.2	BHLHE22	MA0818.2	AMCATATGKY	BHLHE22	4.01e-06	3.36e-09	1110	3.8	855	2.94	1.29
476	65	MA1957.1	HOXB2::ELK1	MA1957.1	RCCGGAAGTMRTTA	HOXB2::ELK1	9.77e-06	8.17e-09	9850	33.7	9160	31.5	1.07
477	11	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	1.35e-05	1.13e-08	22900	78.3	22200	76.4	1.03
478	108	MA0795.1	SMAD3	MA0795.1	YGTCTAGACA	SMAD3	1.59e-05	1.33e-08	5580	19.1	5040	17.3	1.1
479	6	MA0656.1	JDP2	MA0656.1	GATGACGTCAYC	JDP2	1.85e-05	1.54e-08	2560	8.76	2190	7.52	1.17
480	44	MA0761.2	ETV1	MA0761.2	NNACAGGAAGTGNN	ETV1	4.08e-05	3.38e-08	24800	84.8	24200	83.2	1.02
481	107	MA0100.3	MYB	MA0100.3	NNCAACTGHH	MYB	4.19e-05	3.47e-08	14200	48.4	13400	46.2	1.05
482	31	MA0625.2	NFATC3	MA0625.2	RYGGAAAMH	NFATC3	6.03e-05	4.97e-08	19800	67.8	19100	65.8	1.03
483	44	MA1948.1	ETV5::HOXA2	MA1948.1	RVCGGAWGTMATTA	ETV5::HOXA2	6.03e-05	4.97e-08	12600	43	11900	40.8	1.05
484	42	MA0866.1	SOX21	MA0866.1	AACAATKKYAGTGTT	SOX21	0.000111	9.13e-08	810	2.77	613	2.11	1.31
485	108	MA1602.1	ZSCAN29	MA1602.1	YGTCTACRCNGN	ZSCAN29	0.000132	1.08e-07	2790	9.52	2420	8.31	1.15
486	6	MA0609.2	CREM	MA0609.2	NNDGTGACGTCACHNN	CREM	0.00017	1.4e-07	25700	87.7	25100	86.3	1.02
487	44	MA1483.2	ELF2	MA1483.2	AAMCCGGAAGTR	ELF2	0.000313	2.56e-07	13700	47	13100	44.9	1.05
488	54	MA1651.1	ZFP42	MA1651.1	NNNHCAARATGGCTGCCNBNN	ZFP42	0.000583	4.75e-07	17800	60.9	17100	58.9	1.03
489	44	MA0062.3	GABPA	MA0062.3	NNCACTTCCTGTNN	GABPA	0.000718	5.84e-07	7930	27.1	7370	25.4	1.07
490	97	MA0595.1	SREBF1	MA0595.1	VTCACCCCAY	SREBF1	0.00107	8.73e-07	7170	24.5	6640	22.8	1.07
491	52	MA1570.1	TFAP4	MA1570.1	AHCATRTGDT	TFAP4	0.00112	9.07e-07	8780	30	8210	28.2	1.06
492	52	MA1638.1	HAND2	MA1638.1	NVCAGATGNN	HAND2	0.00124	1.01e-06	20300	69.4	19700	67.6	1.03
493	6	MA1951.1	FOS	MA1951.1	BGATGACGTCATCR	FOS	0.00159	1.28e-06	3300	11.3	2930	10.1	1.12
494	67	MA0071.1	RORA	MA0071.1	AWMWAGGTCA	RORA	0.00459	3.7e-06	8620	29.4	8080	27.8	1.06
495	80	MA0804.1	TBX19	MA0804.1	DTTMRCACMTAGGTGTGAAW	TBX19	0.00483	3.89e-06	2940	10	2610	8.98	1.12
496	109	MA1977.1	ZNF324	MA1977.1	NNNWRGMAGHYAAGGATGGTT	ZNF324	0.00711	5.7e-06	10900	37.4	10400	35.6	1.05
497	52	MA0607.2	BHLHA15	MA0607.2	ACCATATGGT	BHLHA15	0.0108	8.68e-06	10700	36.7	10200	35	1.05
498	110	MA1717.1	ZNF784	MA1717.1	GTACYTACCGH	ZNF784	0.0152	1.21e-05	5180	17.7	4780	16.4	1.08
499	111	MA1154.1	ZNF282	MA1154.1	CTTTCCCMYAACACGAB	ZNF282	0.0182	1.45e-05	3270	11.2	2950	10.1	1.1
500	85	MA0777.1	MYBL2	MA0777.1	RRCCGTTAAACBGYY	MYBL2	0.0252	2.01e-05	5230	17.9	4830	16.6	1.08
501	86	MA1971.1	ZBED2	MA1971.1	NNMMCGAAACCNNV	ZBED2	0.048	3.81e-05	15300	52.4	14800	50.8	1.03

ER_rat <- 1.25

DOX_24_up_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( "DOX DAR 24hr sig up response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DOX_24_up_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*10), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./10,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
   ggtitle(paste( "DOX DAR 24hr sig up response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DOX_sigdown_24hr data

DOX_sigdown_24hr_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_down_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DOX_sigdown_24hr_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_down_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DOX_sigdown_24hr_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_down_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DOX_sigdown_24hr_sea_all <- rbind(DOX_sigdown_24hr_sea_disc, DOX_sigdown_24hr_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DOX_sigdown_24hr_combo <- DOX_sigdown_24hr_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DOX_sigdown_24hr_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

DOX_sigdown_24hr_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in DOX_sigdown_24hr v non-DOX sigdown 24hour") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in DOX_sigdown_24hr v non-DOX sigdown 24hour
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA1527.1 (NFIC)	STREME-2	2-CTGCCAGS	CTGCCAGS	NFIC	0	0	21900	75.2	15800	53.9	1.39
2	2	MA1102.2 (CTCFL)	STREME-1	1-CRGCCCC	CRGCCCC	CTCFL	0	0	15600	53.8	9740	33.3	1.61
3	3	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	0	0	18900	65.1	13200	45.1	1.44
4	15	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	0	0	15200	52.4	9690	33.1	1.58
5	4	9-GGCMCT	STREME-9	9-GGCMCT	GGCMCT	GGCMCT	0	0	14000	48.2	8600	29.4	1.64
6	5	MA1653.1 (ZNF148)	MEME-1	GGGGGHGGGGVVGGG	GGGGGHGGGGVVGGG	ZNF148	0	0	20300	69.9	15000	51.2	1.36
7	6	4-GCCAGCG	STREME-4	4-GCCAGCG	GCCAGCG	GCCAGCG	0	0	19700	67.8	14300	49	1.38
8	7	MA1548.1 (PLAGL2)	STREME-3	3-GKGCMC	GKGCMC	PLAGL2	0	0	12500	43	7300	25	1.72
9	8	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	0	0	14000	48	8700	29.7	1.62
10	5	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	0	0	14200	49	9010	30.8	1.59
11	5	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	0	0	16400	56.5	11300	38.5	1.47
12	9	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	0	0	12300	42.4	7420	25.4	1.67
13	10	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	0	0	10900	37.6	6300	21.5	1.75
14	9	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	0	0	13100	44.9	8240	28.2	1.59
15	11	5-GAGGGC	STREME-5	5-GAGGGC	GAGGGC	GAGGGC	0	0	24400	83.9	20300	69.3	1.21
16	12	MA0597.2	THAP1	MA0597.2	VSGCAGGGCASV	THAP1	0	0	17100	58.9	12200	41.6	1.42
17	13	MA1653.1 (ZNF148)	STREME-8	8-CCCTCC	CCCTCC	ZNF148	0	0	18000	61.9	13100	44.7	1.39
18	14	MA0748.2 (YY2)	STREME-7	7-CCGCCA	CCGCCA	YY2	0	0	18800	64.8	14000	47.7	1.36
19	15	MA1713.1 (ZNF610)	STREME-11	11-AGCGGC	11-AGCGGC	ZNF610	0	0	20400	70.2	15700	53.6	1.31
20	16	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	0	0	17600	60.6	12800	43.7	1.39
21	17	MA1654.1 (ZNF16)	STREME-6	6-GGAGCC	GGAGCC	ZNF16	0	0	23500	80.8	19300	65.9	1.23
22	18	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	0	0	14000	48.2	9240	31.6	1.52
23	19	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	0	0	12800	43.9	8100	27.7	1.58
24	20	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	0	0	10300	35.6	5990	20.5	1.74
25	5	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	0	0	7490	25.8	3700	12.6	2.04
26	21	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	0	0	12200	41.9	7660	26.2	1.6
27	22	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	0	0	17200	59.1	12400	42.5	1.39
28	9	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	0	0	12800	44.2	8290	28.3	1.56
29	9	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	0	0	15100	51.9	10400	35.6	1.46
30	3	MA1929.1	CTCF	MA1929.1	CTGCAGTKCCNNNNNYNRCCASYAGRKGGCRSWG	CTCF	0	0	8630	29.7	4660	15.9	1.86
31	23	MA1728.1	ZNF549	MA1728.1	NNTGCTGCCCWR	ZNF549	0	0	22400	77.1	18200	62.2	1.24
32	3	MA0139.1	CTCF	MA0139.1	YGRCCASYAGRKGGCRSYR	CTCF	0	0	8260	28.4	4400	15.1	1.89
33	24	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	4.94065645841247e-324	4.94065645841247e-324	22400	76.9	18200	62.2	1.24
34	9	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	4.25884586715155e-321	1.23516411460312e-322	12500	43	8140	27.8	1.55
35	9	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	1.70999998440975e-316	2.66000003064469e-318	7690	26.4	4050	13.8	1.91
36	18	MA0872.1	TFAP2A	MA0872.1	TGCCCYSRGGGCA	TFAP2A	3.00999999999998e-310	4.55999999999834e-312	8100	27.8	4410	15.1	1.85
37	9	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	1.59e-308	2.34000000000002e-310	13900	47.8	9520	32.5	1.47
38	25	MA1631.1	ASCL1	MA1631.1	NNGCACCTGCYNB	ASCL1	2.41e-305	3.46e-307	20800	71.5	16600	56.6	1.26
39	18	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	3.21e-304	4.49e-306	12500	43.1	8280	28.3	1.52
40	18	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	1.46e-303	1.99e-305	12200	42.1	8020	27.4	1.54
41	18	MA0813.1	TFAP2B	MA0813.1	TGCCCYBRGGGCA	TFAP2B	1.63e-302	2.16e-304	7110	24.4	3660	12.5	1.95
42	18	MA0815.1	TFAP2C	MA0815.1	TGCCCYSRGGGCA	TFAP2C	2.18e-302	2.82e-304	7060	24.3	3630	12.4	1.96
43	9	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	7.38e-301	9.35999999999999e-303	18200	62.6	13800	47.3	1.32
44	10	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	9.79999999999999e-298	1.21e-299	10500	36.3	6540	22.3	1.62
45	26	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	1.65e-291	2e-293	14200	48.7	9890	33.8	1.44
46	9	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	4.19e-290	4.97e-292	13200	45.4	8980	30.7	1.48
47	27	MA0751.1	ZIC4	MA0751.1	GRCCCCCCGCKGYGH	ZIC4	1.12e-288	1.3e-290	11600	39.8	7500	25.6	1.55
48	28	MA1643.1	NFIB	MA1643.1	NNCCTGGCAYNGTGCCAAGNN	NFIB	1.52e-288	1.73e-290	9400	32.3	5610	19.2	1.69
49	3	MA1930.1	CTCF	MA1930.1	CTGCAGTKCCNVCHNNYRGCCASYAGRKGGCRAKC	CTCF	1.62e-285	1.8e-287	6650	22.9	3390	11.6	1.97
50	29	MA1727.1	ZNF417	MA1727.1	VRBVNTGGGCGCCAM	ZNF417	3.3e-283	3.6e-285	13800	47.5	9600	32.8	1.45
51	30	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	1.63e-282	1.74e-284	20800	71.6	16800	57.4	1.25
52	25	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	7.65e-282	8.02e-284	23200	79.7	19500	66.5	1.2
53	25	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	3.74e-278	3.85e-280	15700	54.1	11500	39.3	1.38
54	31	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	1.35e-277	1.37e-279	10700	37	6840	23.4	1.58
55	27	MA1578.1	VEZF1	MA1578.1	CCCCCCMYDH	VEZF1	2.72e-277	2.7e-279	14500	49.7	10300	35.1	1.42
56	31	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	5e-268	4.87e-270	9240	31.8	5600	19.1	1.66
57	18	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	8.21e-268	7.85e-270	18500	63.7	14400	49.3	1.29
58	9	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	1.94e-263	1.83e-265	11500	39.6	7640	26.1	1.52
59	29	MA0024.3	E2F1	MA0024.3	TTTGGCGCCAAA	E2F1	2.92e-262	2.7e-264	10700	36.7	6890	23.6	1.56
60	25	MA1628.1	Zic1::Zic2	MA1628.1	CVCAGCAGGNV	Zic1::Zic2	1.45e-260	1.32e-262	15500	53.3	11400	39	1.37
61	32	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	4.95e-259	4.42e-261	13500	46.2	9450	32.3	1.43
62	25	MA0697.2	Zic3	MA0697.2	CNCAGCAGGAGNN	Zic3	1.81e-258	1.6e-260	14800	51	10800	36.8	1.38
63	33	MA1982.1	ZNF574	MA1982.1	VGSCTAGAGMGGCCS	ZNF574	7.47e-258	6.46e-260	19500	67.1	15600	53.2	1.26
64	28	MA1528.1	NFIX	MA1528.1	STTGGCRNNGTGCCARB	NFIX	1.79e-249	1.53e-251	7960	27.4	4640	15.9	1.72
65	27	MA1584.1	ZIC5	MA1584.1	VGACCCCCCGCTGHGM	ZIC5	1.12e-247	9.39e-250	6250	21.5	3280	11.2	1.92
66	34	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	3.9e-247	3.22e-249	11800	40.7	8040	27.5	1.48
67	28	MA0671.1	NFIX	MA0671.1	NNTGCCAAN	NFIX	4.14e-246	3.37e-248	19000	65.4	15100	51.7	1.27
68	10	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	5.94e-245	4.76e-247	11600	39.9	7830	26.8	1.49
69	25	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	1.38e-244	1.09e-246	9930	34.1	6350	21.7	1.57
70	35	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	1.7e-244	1.32e-246	13500	46.4	9600	32.8	1.41
71	25	MA1648.1	TCF12	MA1648.1	NNCACCTGCNN	TCF12	1.6e-243	1.23e-245	20100	69	16200	55.5	1.24
72	9	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	2.34e-243	1.77e-245	16400	56.4	12400	42.5	1.33
73	27	MA0736.1	GLIS2	MA0736.1	GACCCCCCGCRAMG	GLIS2	3.87e-242	2.89e-244	11600	39.9	7870	26.9	1.48
74	27	MA0696.1	ZIC1	MA0696.1	GACCCCCYGCTGTG	ZIC1	1.61e-240	1.19e-242	7210	24.8	4080	14	1.78
75	36	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	9.15999999999999e-240	6.66e-242	16600	57.1	12700	43.4	1.32
76	35	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	3.23e-239	2.32e-241	16900	58	12900	44.3	1.31
77	37	MA1726.1	ZNF331	MA1726.1	NMYTGCAGAGCCCH	ZNF331	8.45e-239	5.99e-241	14600	50.2	10700	36.6	1.37
78	38	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	4.84e-236	3.38e-238	12600	43.2	8810	30.1	1.44
79	9	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	1.38e-230	9.51e-233	10700	36.8	7140	24.4	1.51
80	39	MA0738.1	HIC2	MA0738.1	RTGCCCRSB	HIC2	1.38e-228	9.37e-231	14200	48.9	10400	35.6	1.37
81	40	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	1.27e-227	8.57e-230	8390	28.9	5140	17.6	1.64
82	9	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	2.29e-225	1.52e-227	5730	19.7	3000	10.2	1.92
83	25	MA0522.3	TCF3	MA0522.3	NVCACCTGCNN	TCF3	9.13e-225	6e-227	20600	70.7	17000	58	1.22
84	25	MA0499.2	MYOD1	MA0499.2	NNGCACCTGTCNB	MYOD1	1.23e-224	8.01e-227	20800	71.5	17200	58.8	1.22
85	10	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	2.76e-223	1.77e-225	21200	72.9	17700	60.4	1.21
86	25	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	8.95e-221	5.67e-223	10500	36.2	7040	24.1	1.5
87	30	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	6.38e-218	4e-220	16400	56.2	12600	43.1	1.3
88	28	MA0739.1	Hic1	MA0739.1	RTGCCAACY	Hic1	1.82e-217	1.13e-219	15900	54.6	12100	41.5	1.32
89	35	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	1.75e-213	1.07e-215	21800	74.8	18400	62.8	1.19
90	27	MA1629.1	Zic2	MA1629.1	NDCACAGCAGGDRG	Zic2	7.04e-212	4.26e-214	15900	54.6	12200	41.7	1.31
91	41	MA1719.1	ZNF816	MA1719.1	DRRKGGGGACATGCHGGG	ZNF816	4.33e-211	2.6e-213	18400	63.3	14800	50.5	1.25
92	18	MA1569.1	TFAP2E	MA1569.1	YGCCYSRGGCD	TFAP2E	1.15e-210	6.83e-213	5340	18.4	2780	9.5	1.93
93	9	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	3.64e-210	2.13e-212	14000	48.2	10400	35.5	1.36
94	9	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	5.19e-209	3.01e-211	14900	51.3	11300	38.5	1.33
95	9	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	8.73e-202	5.01e-204	8420	29	5340	18.3	1.59
96	25	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	3.57e-198	2.03e-200	10600	36.3	7250	24.8	1.46
97	42	MA1637.1	EBF3	MA1637.1	NYCCCAAGGGANN	EBF3	2.05e-196	1.15e-198	16000	55.1	12500	42.6	1.29
98	31	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	4.15e-194	2.31e-196	14100	48.6	10600	36.3	1.34
99	21	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	6.73e-193	3.7e-195	10900	37.4	7580	25.9	1.44
100	25	MA1635.1	BHLHE22	MA1635.1	NVCAGCTGBN	BHLHE22	9.79e-193	5.34e-195	9950	34.2	6750	23.1	1.48
101	3	MA0155.1	INSM1	MA0155.1	TGYCWGGGGGCR	INSM1	1.74e-191	9.37e-194	8920	30.6	5850	20	1.53
102	10	MA0528.2	ZNF263	MA0528.2	VNGGGGAGGASG	ZNF263	7.85e-189	4.2e-191	17300	59.5	13900	47.4	1.26
103	35	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	1.08e-188	5.71e-191	18700	64.2	15300	52.1	1.23
104	9	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	1.19e-188	6.24e-191	12500	42.9	9100	31.1	1.38
105	43	MA0774.1 (MEIS2)	STREME-12	12-GACAGCC	12-GACAGCC	MEIS2	4.76e-186	2.47e-188	11000	37.9	7770	26.6	1.43
106	44	MA1985.1	ZNF669	MA1985.1	GGGGYGAYGACCRCT	ZNF669	1.84e-185	9.44e-188	12500	43	9170	31.3	1.37
107	42	MA0154.4	EBF1	MA0154.4	NNTCCCCAGGGGANN	EBF1	1.76e-181	8.95e-184	15800	54.5	12400	42.5	1.28
108	31	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	1.95e-181	9.82e-184	8800	30.3	5820	19.9	1.52
109	45	MA1730.1	ZNF708	MA1730.1	NNRGCTGTRCCTCCY	ZNF708	8.42e-181	4.21e-183	21700	74.5	18600	63.5	1.17
110	25	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	3.11e-180	1.54e-182	10400	35.8	7270	24.8	1.44
111	25	MA0104.4	MYCN	MA0104.4	VVCCACGTGGBB	MYCN	4.81e-180	2.36e-182	13900	47.9	10600	36.1	1.33
112	31	MA1987.1	ZNF701	MA1987.1	GAGCACYAARGGGGGRADDDD	ZNF701	3.07e-179	1.5e-181	10600	36.4	7420	25.4	1.43
113	25	MA0147.3	MYC	MA0147.3	NNCCACGTGCNB	MYC	1.19e-178	5.75e-181	22500	77.5	19600	66.8	1.16
114	46	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	7.51e-178	3.59e-180	8520	29.3	5610	19.2	1.53
115	47	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	1.35e-177	6.42e-180	8660	29.8	5730	19.6	1.52
116	48	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	6.05e-173	2.85e-175	14100	48.3	10800	36.8	1.31
117	25	MA1966.1	TFAP4::ETV1	MA1966.1	RSCGGAAGCAGSTGKN	TFAP4::ETV1	7e-171	3.26e-173	19400	66.8	16200	55.5	1.2
118	49	MA0145.2	Tfcp2l1	MA0145.2	CCAGYYYVADCCRG	Tfcp2l1	1.62e-170	7.51e-173	11700	40.2	8520	29.1	1.38
119	50	13-CCAGGCCT	STREME-13	13-CCAGGCCT	13-CCAGGCCT	CCAGGCCT	8.53e-170	3.91e-172	17400	60	14200	48.4	1.24
120	25	MA1945.1	ETV5::FIGLA	MA1945.1	RGCGGAARCAGGTGG	ETV5::FIGLA	8.8e-167	4e-169	12200	41.9	9040	30.9	1.36
121	51	MA1656.1	ZNF449	MA1656.1	NNAAGCCCAACCNN	ZNF449	2.49e-165	1.12e-167	16800	57.6	13500	46.2	1.25
122	52	MA1710.1	ZNF257	MA1710.1	VDGAGGCRAGRG	ZNF257	4e-161	1.79e-163	13100	45	9950	34	1.32
123	53	MA0774.1	MEIS2	MA0774.1	TTGACAGS	MEIS2	2.04e-159	9.03e-162	5200	17.9	2970	10.1	1.76
124	47	MA0750.2	ZBTB7A	MA0750.2	NVCCGGAAGTGSV	ZBTB7A	1.09e-158	4.78e-161	14600	50.2	11400	39.1	1.28
125	25	MA1941.1	ETV2::FIGLA	MA1941.1	RSCGGAARCAGSTGBN	ETV2::FIGLA	3.08e-154	1.34e-156	21300	73.2	18400	62.9	1.16
126	25	MA1100.2	ASCL1	MA1100.2	VGCAGCTGCN	ASCL1	1.78e-152	7.71e-155	24300	83.6	21800	74.7	1.12
127	29	MA0864.2	E2F2	MA0864.2	RWTTTGGCGCCAWWWY	E2F2	5.19e-150	2.23e-152	9670	33.3	6860	23.5	1.42
128	9	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	2.51e-149	1.07e-151	19100	65.7	16100	55	1.19
129	25	MA1655.1	ZNF341	MA1655.1	NRGAACAGCCNN	ZNF341	2.6e-147	1.1e-149	21300	73.2	18500	63.1	1.16
130	35	MA0732.1	EGR3	MA0732.1	HHMCGCCCACGCAHH	EGR3	1.52e-146	6.36e-149	7160	24.6	4680	16	1.54
131	54	MA0646.1	GCM1	MA0646.1	BATGCGGGTAC	GCM1	5.31e-146	2.21e-148	18900	65.1	16000	54.6	1.19
132	25	MA1472.2	Bhlha15	MA1472.2	NVACAGCTGTBN	Bhlha15	5.83e-146	2.41e-148	16500	56.8	13500	46.1	1.23
133	30	MA1581.1	ZBTB6	MA1581.1	DNSCTTGAGCCNV	ZBTB6	6.88e-146	2.82e-148	16400	56.2	13300	45.5	1.24
134	55	MA1972.1	ZFP14	MA1972.1	GGAGGCHCHGGARBG	ZFP14	5.77e-144	2.35e-146	18200	62.6	15200	52	1.2
135	56	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	6.48e-144	2.62e-146	14400	49.4	11300	38.8	1.27
136	25	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	7.45e-143	2.99e-145	12700	43.7	9760	33.4	1.31
137	42	MA1604.1	Ebf2	MA1604.1	NYCCCAAGGGANN	Ebf2	3.6e-140	1.43e-142	20600	70.9	17800	60.9	1.16
138	25	MA2002.1	Zfp335	MA2002.1	VNTCAGGCANH	Zfp335	2.14e-136	8.47e-139	23500	80.7	21000	71.9	1.12
139	29	MA0470.2	E2F4	MA0470.2	TTTTGGCGCCAWWW	E2F4	3.27e-136	1.28e-138	6700	23	4360	14.9	1.54
140	34	MA1587.1	ZNF135	MA1587.1	CCTCGACCTCCYRR	ZNF135	1.17e-133	4.54e-136	14800	50.8	11900	40.6	1.25
141	25	MA0500.2	MYOG	MA0500.2	NDRCAGCTGYHN	MYOG	1.28e-133	4.95e-136	23700	81.6	21300	72.9	1.12
142	57	MA1979.1	ZNF416	MA1979.1	TATCTGGGCAH	ZNF416	1.84e-133	7.08e-136	22500	77.5	20000	68.4	1.13
143	21	MA0163.1	PLAG1	MA0163.1	GGGGCCCWAGGGGG	PLAG1	5.69e-132	2.17e-134	4330	14.9	2450	8.37	1.78
144	58	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	2.78e-131	1.05e-133	7010	24.1	4670	16	1.51
145	25	MA1641.1	MYF5	MA1641.1	NVACAGCTGTBN	MYF5	5.81e-130	2.18e-132	17000	58.5	14200	48.4	1.21
146	59	MA0855.1 (RXRB)	STREME-10	10-GACCSC	10-GACCSC	RXRB	3.45e-127	1.29e-129	13300	45.9	10500	36	1.27
147	60	MA1149.1	RARA::RXRG	MA1149.1	RRGGTCAHNNNRRGGTCA	RARA::RXRG	4.25e-125	1.57e-127	10200	35.1	7580	25.9	1.35
148	25	MA0745.2	SNAI2	MA0745.2	NBGCACCTGTMNY	SNAI2	1.03e-123	3.79e-126	21800	74.8	19200	65.8	1.14
149	48	MA0694.1	ZBTB7B	MA0694.1	RCGACCACCGAA	ZBTB7B	3.41e-123	1.25e-125	12000	41.1	9260	31.6	1.3
150	61	MA0504.1	NR2C2	MA0504.1	VGRGGTCARAGGTCA	NR2C2	3.56e-123	1.29e-125	10700	36.7	8050	27.5	1.33
151	62	MA1731.1	ZNF768	MA1731.1	YBVCYBRSCCTCTCTGDG	ZNF768	1.84e-121	6.63e-124	12400	42.6	9670	33.1	1.29
152	60	MA1535.1	NR2C1	MA1535.1	NRRGGTCAN	NR2C1	4.8e-120	1.72e-122	23900	82.3	21700	74.3	1.11
153	25	MA0048.2	NHLH1	MA0048.2	CGCAGCTGCK	NHLH1	3.93e-116	1.4e-118	18300	62.8	15600	53.4	1.18
154	63	MA1973.1	ZKSCAN3	MA1973.1	KDKCCCAGGCTAGCCCABNN	ZKSCAN3	4.82e-116	1.71e-118	10200	34.9	7640	26.1	1.34
155	53	MA0138.2	REST	MA0138.2	TTCAGCACCATGGACAGCDCC	REST	9.37e-114	3.29e-116	6800	23.4	4640	15.8	1.47
156	64	MA1716.1	ZNF76	MA1716.1	NNTWCCCAYAATGCAHYGCGC	ZNF76	1.24e-111	4.35e-114	9430	32.4	7010	24	1.35
157	48	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	8.23e-110	2.86e-112	26000	89.6	24300	83.2	1.08
158	76	MA0672.1	NKX2-3	MA0672.1	VCCACTTRAV	NKX2-3	1.97e-109	6.79e-112	5920	20.4	3920	13.4	1.52
159	25	MA0649.1	HEY2	MA0649.1	GRCACGTGYC	HEY2	3.44e-109	1.18e-111	11300	39	8820	30.1	1.29
160	25	MA1621.1	Rbpjl	MA1621.1	NNVACACCTGTBNN	Rbpjl	1.07e-104	3.64e-107	23500	80.8	21400	73.2	1.1
161	60	MA0159.1	RARA::RXRA	MA0159.1	RGKTCANVGRSAGGTCA	RARA::RXRA	2.04e-103	6.92e-106	14200	48.8	11700	39.8	1.23
162	76	MA2003.1	NKX2-4	MA2003.1	CCACTTSAVV	NKX2-4	9.02e-103	3.03e-105	12600	43.4	10100	34.6	1.25
163	65	MA1715.1	ZNF707	MA1715.1	CCCCACTCCTGGTAC	ZNF707	2.99e-101	1e-103	10600	36.3	8170	27.9	1.3
164	25	MA1938.1	ERF::NHLH1	MA1938.1	VGCAGCTGCCGGAARYN	ERF::NHLH1	2.16e-97	7.18e-100	7980	27.4	5850	20	1.37
165	25	MA1619.1	Ptf1A	MA1619.1	NNACAGCTGTNN	Ptf1A	2.45e-95	8.08e-98	23600	81.2	21700	74	1.1
166	48	MA0695.1	ZBTB7C	MA0695.1	RCGACCACCGAN	ZBTB7C	5.68e-95	1.87e-97	17200	59.2	14800	50.6	1.17
167	25	MA0103.3	ZEB1	MA0103.3	SNCACCTGSVN	ZEB1	1.03e-94	3.35e-97	21600	74.4	19500	66.5	1.12
168	28	MA1527.1	NFIC	MA1527.1	NTTGGCDNNRTGCCARN	NFIC	4.23e-91	1.37e-93	3130	10.8	1770	6.06	1.77
169	54	MA0767.1	GCM2	MA0767.1	BATGCGGGTR	GCM2	2.29e-90	7.39e-93	9880	34	7670	26.2	1.3
170	66	MA1964.1	SMAD2	MA1964.1	NBCCAGACDN	SMAD2	9.87e-90	3.17e-92	11800	40.5	9480	32.4	1.25
171	67	MA0803.1	TBX15	MA0803.1	AGGTGTGA	TBX15	1.59e-88	5.06e-91	23200	79.6	21200	72.5	1.1
172	25	MA1099.2	HES1	MA1099.2	GGCRCGTGBC	HES1	1.77e-87	5.6e-90	4180	14.4	2640	9.03	1.59
173	47	MA0764.3	ETV4	MA0764.3	ACCGGAAGTR	ETV4	3.09e-87	9.75e-90	12900	44.5	10600	36.3	1.22
174	25	MA0521.2	Tcf12	MA0521.2	NNACAGCTGTNN	Tcf12	3.75e-86	1.18e-88	8110	27.9	6080	20.8	1.34
175	68	MA1600.1	ZNF684	MA1600.1	RYACAGTCCACCCCTTKR	ZNF684	1.21e-85	3.77e-88	9640	33.2	7500	25.6	1.29
176	69	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	1.27e-85	3.94e-88	6560	22.6	4700	16	1.4
177	70	MA0130.1	ZNF354C	MA0130.1	MTCCAC	ZNF354C	4.54e-85	1.4e-87	27100	93.2	25900	88.5	1.05
178	71	MA1711.1	ZNF343	MA1711.1	CCGCTTCMCCDCGGCMV	ZNF343	3.34e-84	1.02e-86	6490	22.3	4650	15.9	1.4
179	72	MA1575.1	THRB	MA1575.1	DTGACCTBRNYVAGGTCAH	THRB	8.78e-83	2.67e-85	5700	19.6	3980	13.6	1.44
180	53	MA0775.1	MEIS3	MA0775.1	DTGACAGS	MEIS3	3.4e-82	1.03e-84	3950	13.6	2500	8.53	1.59
181	25	MA0616.2	HES2	MA0616.2	GGCACGTGYC	HES2	1.49e-81	4.5e-84	8620	29.6	6600	22.6	1.31
182	25	MA0816.1	Ascl2	MA0816.1	ARCAGCTGCY	Ascl2	5.44e-80	1.63e-82	18800	64.7	16600	56.9	1.14
183	28	MA0161.2	NFIC	MA0161.2	NNCTTGGCANN	NFIC	8.52e-80	2.54e-82	15500	53.2	13200	45.2	1.18
184	67	MA1566.2	TBX3	MA1566.2	RAGGTGTGAAV	TBX3	1.33e-78	3.95e-81	22100	76	20200	69	1.1
185	67	MA0806.1	TBX4	MA0806.1	AGGTGTGA	TBX4	3.18e-78	9.37e-81	22800	78.5	21000	71.7	1.1
186	28	MA0119.1	NFIC::TLX1	MA0119.1	TGGCASSRWGCCAA	NFIC::TLX1	8.62e-78	2.53e-80	2820	9.7	1620	5.55	1.75
187	25	MA1485.1	FERD3L	MA1485.1	GCRMCAGCTGTYAC	FERD3L	1.29e-77	3.75e-80	6040	20.8	4320	14.8	1.41
188	25	MA0807.1	TBX5	MA0807.1	AGGTGTKA	TBX5	1.62e-75	4.71e-78	21800	74.8	19800	67.8	1.1
189	25	MA1620.1	Ptf1A	MA1620.1	NVACACCTGTNN	Ptf1A	2.14e-75	6.17e-78	25400	87.4	23900	81.8	1.07
190	47	MA0765.3	ETV5	MA0765.3	ACCGGAAGTR	ETV5	3.27e-75	9.37e-78	7000	24.1	5210	17.8	1.35
191	53	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	7.82e-73	2.23e-75	16200	55.6	14000	48	1.16
192	73	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	8.89e-71	2.52e-73	3430	11.8	2160	7.39	1.6
193	72	MA1533.1	NR1I2	MA1533.1	DYGAACTSVDTGAACTC	NR1I2	1.75e-70	4.95e-73	11000	37.8	8970	30.6	1.23
194	76	MA0673.1	NKX2-8	MA0673.1	VCACTTSAV	NKX2-8	3.2e-70	9.01e-73	6570	22.6	4880	16.7	1.36
195	25	MA1652.1	ZKSCAN5	MA1652.1	NNRGGARGTGAGRR	ZKSCAN5	2.45e-69	6.85e-72	12200	42	10200	34.8	1.21
196	47	MA1992.1	Ikzf3	MA1992.1	NNRCAGGAAGTGGVN	Ikzf3	8.83e-68	2.46e-70	19700	67.7	17700	60.7	1.12
197	25	MA1558.1	SNAI1	MA1558.1	DRCAGGTGYD	SNAI1	9.94e-67	2.75e-69	17500	60.1	15500	52.9	1.14
198	61	MA0065.2	Pparg::Rxra	MA0065.2	STRGGGCARAGGKCA	Pparg::Rxra	1.74e-66	4.78e-69	17300	59.6	15300	52.4	1.14
199	25	MA0820.1	FIGLA	MA0820.1	WMCACCTGKW	FIGLA	4.74e-65	1.3e-67	26100	89.6	24800	84.9	1.06
200	47	MA1933.1	ELK1::SREBF2	MA1933.1	DCCGGAAGTSRCGTGA	ELK1::SREBF2	1.17e-64	3.19e-67	9240	31.8	7400	25.3	1.26
201	74	MA1474.1	CREB3L4	MA1474.1	YGCCACGTCAYC	CREB3L4	2.06e-63	5.57e-66	7930	27.3	6200	21.2	1.29
202	25	MA0668.2	Neurod2	MA0668.2	NNGRACAGATGGYNN	Neurod2	2.07e-63	5.57e-66	20200	69.4	18400	62.7	1.11
203	75	MA1468.1	ATOH7	MA1468.1	AVCATATGBY	ATOH7	2.43e-63	6.52e-66	25900	89	24600	84.1	1.06
204	76	MA1994.1 (Nkx2-1)	STREME-15	15-CCACTTGA	15-CCACTTGA	Nkx2-1	3.13e-62	8.36e-65	3050	10.5	1920	6.56	1.6
205	53	MA1571.1	TGIF2LX	MA1571.1	TGACAGCTGTCA	TGIF2LX	4.17e-62	1.11e-64	15600	53.8	13700	46.8	1.15
206	77	MA1969.1	THRA	MA1969.1	NYTGTGTCCTCABRTGACCTYWBB	THRA	6.7e-62	1.77e-64	8820	30.3	7040	24.1	1.26
207	25	MA1106.1	HIF1A	MA1106.1	SBACGTGCNN	HIF1A	8.06e-62	2.12e-64	11400	39.2	9510	32.5	1.21
208	25	MA0464.2	BHLHE40	MA0464.2	VKCACGTGMC	BHLHE40	4.73e-61	1.24e-63	11800	40.6	9910	33.9	1.2
209	25	MA1560.1	SOHLH2	MA1560.1	YGCACGTGCN	SOHLH2	1.44e-60	3.75e-63	17200	59.2	15300	52.3	1.13
210	25	MA1493.1	HES6	MA1493.1	GGCACGTGTY	HES6	1.88e-59	4.88e-62	15300	52.6	13400	45.7	1.15
211	74	MA0259.1	ARNT::HIF1A	MA0259.1	VBACGTGC	ARNT::HIF1A	1.95e-59	5.03e-62	10400	35.9	8610	29.4	1.22
212	67	MA0801.1	MGA	MA0801.1	AGGTGTGA	MGA	1.06e-57	2.73e-60	20100	69	18300	62.5	1.1
213	78	MA0511.2	RUNX2	MA0511.2	WAACCGCAA	RUNX2	6.95e-57	1.78e-59	21100	72.6	19400	66.4	1.09
214	79	MA1545.1	OVOL2	MA1545.1	DDACCGTTABNYN	OVOL2	5.31e-56	1.35e-58	5240	18	3850	13.2	1.37
215	61	MA1574.1	THRB	MA1574.1	RRGGTCAAAGGTCAN	THRB	3.39e-55	8.58e-58	17100	58.8	15300	52.2	1.13
216	25	MA1559.1	SNAI3	MA1559.1	RRCAGGTGYA	SNAI3	6.63e-55	1.67e-57	17900	61.7	16100	55.2	1.12
217	76	MA1464.1	ARNT2	MA1464.1	GTCACGTGMN	ARNT2	3.71e-52	9.33e-55	8390	28.8	6780	23.2	1.24
218	76	MA0608.1	Creb3l2	MA0608.1	GCCACGTGD	Creb3l2	7.01e-52	1.75e-54	6510	22.4	5050	17.3	1.3
219	53	MA1572.1	TGIF2LY	MA1572.1	TGACAGCTGTCA	TGIF2LY	6.02e-51	1.5e-53	11300	39	9610	32.9	1.19
220	76	MA0058.3	MAX	MA0058.3	AVCACGTGNY	MAX	6.57e-51	1.63e-53	17500	60.1	15700	53.8	1.12
221	75	MA0665.1	MSC	MA0665.1	AACAGCTGTT	MSC	5.66e-50	1.4e-52	13700	47	11900	40.7	1.15
222	47	MA0028.2	ELK1	MA0028.2	ACCGGAAGTR	ELK1	7.67e-50	1.88e-52	12600	43.2	10800	37	1.17
223	25	MA1529.1	NHLH2	MA1529.1	GGGNCGCAGCTGCGYCCC	NHLH2	7.85e-50	1.92e-52	6980	24	5500	18.8	1.28
224	80	MA0778.1	NFKB2	MA0778.1	AGGGGAWTCCCCY	NFKB2	7.09e-49	1.73e-51	5110	17.6	3830	13.1	1.34
225	47	MA0760.1	ERF	MA0760.1	ACCGGAAGTR	ERF	6.92e-48	1.68e-50	20800	71.5	19200	65.8	1.09
226	81	MA1684.1	Foxn1	MA1684.1	RGAMGC	Foxn1	3.74e-47	9.03e-50	7130	24.5	5690	19.4	1.26
227	82	MA1556.1	RXRG	MA1556.1	RRGGTCAYGACCYY	RXRG	1.55e-46	3.71e-49	7690	26.4	6210	21.2	1.24
228	25	MA1646.1	OSR2	MA1646.1	NNACAGAAGCNN	OSR2	2.39e-46	5.7e-49	21200	73.1	19700	67.5	1.08
229	47	MA0156.3	FEV	MA0156.3	VACCGGAAGTVV	FEV	4.93e-46	1.17e-48	7320	25.2	5880	20.1	1.25
230	61	MA1147.1	NR4A2::RXRA	MA1147.1	VRGGTCRTTGACCYY	NR4A2::RXRA	1.62e-44	3.85e-47	14000	48.2	12400	42.2	1.14
231	25	MA1934.1	ERF::FIGLA	MA1934.1	RCCGGAARCASCTGBN	ERF::FIGLA	4.18e-44	9.87e-47	3520	12.1	2490	8.51	1.42
232	76	MA0603.1	Arntl	MA0603.1	NGTCACGTGH	Arntl	2.05e-43	4.81e-46	8620	29.7	7140	24.4	1.21
233	83	MA1531.1	NR1D1	MA1531.1	RGGTYAGTRGGTCAN	NR1D1	2.2e-43	5.15e-46	4940	17	3750	12.8	1.33
234	25	MA0822.1	HES7	MA0822.1	YGGCACGTGCCR	HES7	3.85e-42	8.96e-45	1790	6.14	1070	3.64	1.68
235	84	MA1542.1	OSR1	MA1542.1	HGCTACYGTD	OSR1	4.46e-41	1.03e-43	21100	72.7	19700	67.5	1.08
236	85	MA1554.1	RFX7	MA1554.1	CGTTGCYAY	RFX7	8.89e-41	2.05e-43	25300	87.1	24300	83.1	1.05
237	86	MA0502.2	NFYB	MA0502.2	CYCATTGGCCVV	NFYB	1.36e-40	3.12e-43	6580	22.6	5270	18	1.25
238	31	MA1565.1	TBX18	MA1565.1	DRAGGTGTGAAR	TBX18	2.9e-40	6.64e-43	10000	34.4	8530	29.2	1.18
239	82	MA1538.1	NR2F1	MA1538.1	RAGGTCANTGACCTY	NR2F1	5.4e-39	1.23e-41	8010	27.6	6640	22.7	1.21
240	31	MA1567.2	Tbx6	MA1567.2	NRGGTGTGAANN	Tbx6	5.8e-39	1.32e-41	16400	56.4	14900	50.9	1.11
241	87	MA1999.1	Prdm5	MA1999.1	CBGTTCTCCATCTNN	Prdm5	2.65e-38	5.99e-41	26800	92	26000	88.8	1.04
242	45	MA1725.1	ZNF189	MA1725.1	NNTGCTGTTCCHB	ZNF189	6.23e-37	1.4e-39	23600	81	22400	76.6	1.06
243	60	MA0258.2	ESR2	MA0258.2	AGGTCASVNTGMCCY	ESR2	7.11e-37	1.59e-39	17700	61	16300	55.6	1.1
244	88	MA0116.1	Znf423	MA0116.1	GSMMCCYARGGKKBM	Znf423	7.76e-37	1.73e-39	1720	5.91	1050	3.6	1.64
245	53	MA0797.1	TGIF2	MA0797.1	TGACAGSTGTCA	TGIF2	4.58e-36	1.02e-38	9350	32.1	7960	27.2	1.18
246	28	MA0670.1	NFIA	MA0670.1	NDTGCCAAND	NFIA	8.96e-36	1.99e-38	3950	13.6	2960	10.1	1.34
247	67	MA0805.1	TBX1	MA0805.1	AGGTGTGA	TBX1	2.53e-35	5.59e-38	17700	60.8	16300	55.6	1.09
248	25	MA0004.1	Arnt	MA0004.1	CACGTG	Arnt	2.21e-33	4.86e-36	6540	22.5	5360	18.3	1.23
249	25	MA1109.1	NEUROD1	MA1109.1	NRACAGATGGYNN	NEUROD1	2.6e-32	5.68e-35	27700	95.4	27200	93	1.03
250	80	MA1117.1	RELB	MA1117.1	RDATTCCCCNN	RELB	2.96e-31	6.45e-34	9340	32.1	8050	27.5	1.17
251	53	MA1114.1	PBX3	MA1114.1	NNNTGAGTGACAGGBNN	PBX3	4.1e-31	8.9e-34	13100	45	11700	40	1.12
252	76	MA0692.1	TFEB	MA0692.1	RYCACGTGAC	TFEB	9.48e-30	2.05e-32	23800	81.9	22800	78	1.05
253	74	MA1475.1	CREB3L4	MA1475.1	GRTGACGTCAYC	CREB3L4	1.93e-29	4.16e-32	7620	26.2	6440	22	1.19
254	47	MA0076.2	ELK4	MA0076.2	BCRCTTCCGGB	ELK4	5.4e-29	1.16e-31	353	1.21	109	0.37	3.24
255	89	MA0863.1	MTF1	MA0863.1	TTTGCACACGGCAC	MTF1	6.04e-29	1.29e-31	2360	8.13	1660	5.68	1.43
256	90	MA1971.1	ZBED2	MA1971.1	NNMMCGAAACCNNV	ZBED2	8.49e-29	1.81e-31	2440	8.38	1720	5.9	1.42
257	67	MA0690.2	TBX21	MA0690.2	TTTCACACCTT	TBX21	3.22e-28	6.84e-31	20900	71.9	19800	67.5	1.07
258	74	MA0615.1	Gmeb1	MA0615.1	BHBBKKACGTMMNWNNN	Gmeb1	1.26e-27	2.67e-30	1340	4.62	829	2.83	1.63
259	48	MA0737.1	GLIS3	MA0737.1	GACCCCCCACGAAG	GLIS3	1.44e-27	3.03e-30	2280	7.85	1610	5.5	1.43
260	86	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	6.36e-25	1.33e-27	679	2.33	340	1.16	2.01
261	41	MA0056.2	MZF1	MA0056.2	NNAATCCCCANNN	MZF1	3.81e-23	7.95e-26	25200	86.5	24400	83.4	1.04
262	76	MA0124.2	Nkx3-1	MA0124.2	RCCACTTAA	Nkx3-1	1.11e-22	2.31e-25	1870	6.43	1310	4.47	1.44
263	74	MA0839.1	CREB3L1	MA0839.1	VTGCCACGTCAYCA	CREB3L1	1.48e-22	3.07e-25	7380	25.4	6360	21.7	1.17
264	86	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	1.49e-22	3.07e-25	907	3.12	525	1.79	1.74
265	91	MA1649.1	ZBTB12	MA1649.1	NYCTRGAACHN	ZBTB12	3.32e-21	6.83e-24	21600	74.2	20600	70.5	1.05
266	60	MA0017.2	NR2F1	MA0017.2	CARAGGTCAMVNG	NR2F1	4.33e-21	8.88e-24	7580	26.1	6580	22.5	1.16
267	47	MA1484.1	ETS2	MA1484.1	DACCGGAAGY	ETS2	7.39e-21	1.51e-23	1220	4.21	791	2.7	1.56
268	73	MA0067.2	PAX2	MA0067.2	BCAVTSRAGCGTGACGR	PAX2	1.6e-19	3.25e-22	2160	7.44	1600	5.47	1.36
269	74	MA0636.1	BHLHE41	MA0636.1	RTCACGTGAC	BHLHE41	1.61e-19	3.26e-22	3490	12	2790	9.53	1.26
270	75	MA1967.1	TFAP4::FLI1	MA1967.1	ACCGGAAACAGCTGDY	TFAP4::FLI1	2.78e-19	5.62e-22	2550	8.76	1940	6.63	1.32
271	92	MA1654.1	ZNF16	MA1654.1	AVTRGGGAGCCATGGAAGGTTYT	ZNF16	4.98e-19	1e-21	3440	11.8	2750	9.39	1.26
272	93	MA1597.1	ZNF528	MA1597.1	CCCAGGGAAGCCATTTC	ZNF528	6.14e-19	1.23e-21	6780	23.3	5860	20	1.16
273	53	MA0796.1	TGIF1	MA0796.1	TGACAGCTGTCA	TGIF1	7.04e-19	1.41e-21	944	3.25	582	1.99	1.63
274	94	MA1146.1	NR1H4::RXRA	MA1146.1	GAGKTCATTGACCYB	NR1H4::RXRA	1.06e-18	2.1e-21	3080	10.6	2430	8.31	1.28
275	74	MA0609.2	CREM	MA0609.2	NNDGTGACGTCACHNN	CREM	4.01e-18	7.95e-21	13800	47.4	12700	43.5	1.09
276	47	MA0686.1	SPDEF	MA0686.1	AMCCGGATGTR	SPDEF	5.41e-18	1.07e-20	10900	37.4	9850	33.7	1.11
277	95	MA1651.1	ZFP42	MA1651.1	NNNHCAARATGGCTGCCNBNN	ZFP42	1.2e-17	2.37e-20	3430	11.8	2760	9.43	1.25
278	9	MA0657.1	KLF13	MA0657.1	RTGMCACGCCCCTTTTTG	KLF13	1.97e-17	3.87e-20	2510	8.64	1940	6.62	1.3
279	60	MA1536.1	NR2C2	MA1536.1	RRGGTCAN	NR2C2	2.1e-17	4.1e-20	1170	4.01	775	2.65	1.51
280	36	MA0006.1	Ahr::Arnt	MA0006.1	YGCGTG	Ahr::Arnt	2.12e-17	4.13e-20	20200	69.5	19300	66	1.05
281	103	MA1573.2	Thap11	MA1573.2	ACTACAABTCCCAG	Thap11	3.7e-17	7.19e-20	15200	52.4	14200	48.6	1.08
282	53	MA0783.1	PKNOX2	MA0783.1	TGACAGGTGTCA	PKNOX2	1.21e-16	2.33e-19	1300	4.45	890	3.04	1.46
283	47	MA0475.2	FLI1	MA0475.2	ACCGGAARTR	FLI1	2.09e-16	4.02e-19	699	2.4	409	1.4	1.72
284	76	MA0664.1	MLXIPL	MA0664.1	RTCACGTGAT	MLXIPL	2.16e-16	4.14e-19	12100	41.7	11100	38	1.1
285	28	MA0092.1	Hand1::Tcf3	MA0092.1	BRTCTGGMWT	Hand1::Tcf3	2.84e-16	5.43e-19	26400	90.9	25900	88.6	1.03
286	76	MA1994.1	Nkx2-1	MA1994.1	NVCACTTGARHNN	Nkx2-1	3.77e-16	7.19e-19	1410	4.86	995	3.4	1.43
287	47	MA0098.3	ETS1	MA0098.3	ACCGGAARTR	ETS1	6.93e-16	1.32e-18	685	2.36	402	1.37	1.71
288	47	MA0645.1	ETV6	MA0645.1	MSCGGAAGTR	ETV6	1.22e-15	2.3e-18	13000	44.7	12000	41.1	1.09
289	85	MA0799.2	RFX4	MA0799.2	BSGTTGCYWRGCAACSV	RFX4	1.73e-15	3.26e-18	1320	4.55	927	3.17	1.44
290	78	MA0002.2	Runx1	MA0002.2	BBYTGTGGTTT	Runx1	3.72e-15	7e-18	26900	92.4	26400	90.3	1.02
291	25	MA0825.1	MNT	MA0825.1	RVCACGTGMH	MNT	4.02e-15	7.53e-18	14300	49	13300	45.5	1.08
292	61	MA1537.1	NR2F1	MA1537.1	RRGGTCAAAGGTCAN	NR2F1	7.52e-15	1.4e-17	5130	17.6	4400	15	1.17
293	47	MA0641.1	ELF4	MA0641.1	AACCCGGAAGTR	ELF4	7.6e-15	1.42e-17	4760	16.4	4050	13.8	1.18
294	47	MA0473.3	ELF1	MA0473.3	RDVCAGGAAGTGVN	ELF1	8.72e-15	1.62e-17	18300	63	17400	59.5	1.06
295	82	MA1555.1	RXRB	MA1555.1	RRGGTCATGACCYY	RXRB	5.99e-14	1.11e-16	12600	43.2	11700	39.9	1.08
296	75	MA1568.1	TCF21	MA1568.1	CACCATATGKYR	TCF21	3.95e-13	7.27e-16	9220	31.7	8380	28.6	1.11
297	25	MA0819.2	CLOCK	MA0819.2	NRACACGTGB	CLOCK	4.64e-13	8.52e-16	5340	18.4	4640	15.9	1.16
298	61	MA1540.2	NR5A1	MA1540.2	NNRAGTTCAAGGTCANN	NR5A1	2.07e-12	3.79e-15	18200	62.6	17400	59.4	1.05
299	80	MA0107.1	RELA	MA0107.1	GGGRATTTCC	RELA	3.33e-12	6.06e-15	6710	23.1	5970	20.4	1.13
300	96	MA1121.1	TEAD2	MA1121.1	NYACATTCCWNNS	TEAD2	4.02e-12	7.3e-15	2220	7.62	1760	6	1.27
301	96	MA0808.1	TEAD3	MA0808.1	RCATTCCW	TEAD3	5.33e-12	9.65e-15	4140	14.2	3530	12.1	1.18
302	75	MA1570.1	TFAP4	MA1570.1	AHCATRTGDT	TFAP4	6.55e-12	1.18e-14	19700	67.7	18900	64.7	1.05
303	97	MA1601.2	ZNF75D	MA1601.2	GTGGGAAAGCCT	ZNF75D	1.11e-11	2e-14	13100	45.2	12300	42	1.07
304	47	MA1483.2	ELF2	MA1483.2	AAMCCGGAAGTR	ELF2	2.26e-11	4.05e-14	514	1.77	303	1.04	1.7
305	25	MA1642.1	NEUROG2	MA1642.1	NNVACAGATGGNN	NEUROG2	1.21e-10	2.16e-13	27100	93.3	26800	91.7	1.02
306	80	MA0101.1	REL	MA0101.1	BGGRNWTTCC	REL	1.64e-10	2.93e-13	3420	11.8	2900	9.91	1.19
307	94	MA1539.1	NR2F6	MA1539.1	RAGGTCANTGACCTY	NR2F6	1.89e-10	3.35e-13	2550	8.76	2090	7.14	1.23
308	98	MA1645.1	NKX2-2	MA1645.1	NNNCCACTCAANNN	NKX2-2	1.9e-10	3.36e-13	3300	11.3	2780	9.51	1.19
309	99	MA1593.1 (ZNF317)	STREME-14	14-TTCAGCAGACTTAAA	14-TTCAGCAGACTTAAA	ZNF317	2.52e-10	4.44e-13	46	0.16	1	0	23.6
310	47	MA0763.1	ETV3	MA0763.1	ACCGGAAGTR	ETV3	2.9e-10	5.09e-13	3570	12.3	3040	10.4	1.18
311	92	MA1977.1	ZNF324	MA1977.1	NNNWRGMAGHYAAGGATGGTT	ZNF324	3.42e-10	6e-13	15600	53.5	14800	50.6	1.06
312	47	MA1708.1	ETV7	MA1708.1	DGSCGGAAGTR	ETV7	1.15e-09	2.01e-12	8500	29.2	7800	26.6	1.1
313	25	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	3.41e-09	5.94e-12	5450	18.8	4850	16.6	1.13
314	85	MA1724.1	Rfx6	MA1724.1	HNCCTAGCAACHV	Rfx6	4.23e-09	7.34e-12	28700	98.7	28700	98	1.01
315	48	MA1491.2	GLI3	MA1491.2	RGACCACCCACGWHGH	GLI3	8.38e-09	1.45e-11	1250	4.31	951	3.25	1.33
316	25	MA0640.2	ELF3	MA0640.2	NNCCACTTCCTGNT	ELF3	2.23e-08	3.85e-11	22300	76.7	21800	74.4	1.03
317	47	MA0474.3	Erg	MA0474.3	NNACAGGAAGTGVN	Erg	3.51e-08	6.04e-11	17200	59.1	16500	56.4	1.05
318	80	MA0105.4	NFKB1	MA0105.4	AGGGGAWTCCCCT	NFKB1	4.41e-08	7.57e-11	1170	4.01	885	3.02	1.33
319	100	MA1984.1	ZNF667	MA1984.1	TTAAGAGCTCAV	ZNF667	5.02e-08	8.58e-11	11800	40.4	11100	37.8	1.07
320	47	MA0062.3	GABPA	MA0062.3	NNCACTTCCTGTNN	GABPA	5.72e-08	9.75e-11	16800	57.6	16100	55	1.05
321	61	MA0677.1	Nr2f6	MA0677.1	RRGGTCAAAGGTCA	Nr2f6	1.22e-07	2.08e-10	8340	28.7	7700	26.3	1.09
322	74	MA1466.1	ATF6	MA1466.1	TGRTGACGTGGCAN	ATF6	3.5e-07	5.93e-10	1730	5.96	1410	4.81	1.24
323	76	MA0914.1	ISL2	MA0914.1	GCAMTTAR	ISL2	3.87e-07	6.54e-10	1280	4.38	995	3.4	1.29
324	47	MA1931.1	ELK1::HOXA1	MA1931.1	ACCGGAAGTAATTA	ELK1::HOXA1	4.45e-07	7.48e-10	6220	21.4	5660	19.4	1.11
325	85	MA0798.3	RFX3	MA0798.3	CGTTRCCATGGCAACS	RFX3	7.68e-07	1.29e-09	86	0.3	24	0.08	3.5
326	96	MA0809.2	TEAD4	MA0809.2	NNACATTCCARN	TEAD4	9.84e-07	1.65e-09	1840	6.34	1520	5.19	1.22
327	85	MA0509.3	RFX1	MA0509.3	SGTTGCCATGGCAACS	RFX1	3.31e-06	5.52e-09	105	0.36	37	0.13	2.81
328	25	MA1638.1	HAND2	MA1638.1	NVCAGATGNN	HAND2	4.92e-06	8.17e-09	25000	85.9	24600	84.2	1.02
329	97	MA1116.1	RBPJ	MA1116.1	BVTGGGAANN	RBPJ	5.41e-06	8.97e-09	3560	12.2	3140	10.7	1.14
330	101	MA0505.2	Nr5A2	MA0505.2	NTGACCTTGAMCT	Nr5A2	5.93e-06	9.8e-09	10200	35.2	9640	32.9	1.07
331	73	MA1995.1	Npas4	MA1995.1	NNTCGTGACHN	Npas4	6.65e-06	1.1e-08	2280	7.84	1940	6.62	1.18
332	75	MA0667.1	MYF6	MA0667.1	AACARCTGTT	MYF6	7.15e-06	1.17e-08	9170	31.5	8600	29.4	1.07
333	96	MA0090.3	TEAD1	MA0090.3	NNACATTCCAGSN	TEAD1	8.44e-06	1.38e-08	2190	7.52	1850	6.33	1.19
334	25	MA0100.3	MYB	MA0100.3	NNCAACTGHH	MYB	9.34e-06	1.52e-08	5320	18.3	4830	16.5	1.11
335	102	MA0111.1	Spz1	MA0111.1	AGGGTWWCAGC	Spz1	1.04e-05	1.69e-08	15200	52.3	14600	50	1.05
336	85	MA0600.2	RFX2	MA0600.2	SGTTGCCATGGYAACS	RFX2	1.3e-05	2.11e-08	122	0.42	50	0.17	2.43
337	76	MA0622.1	Mlxip	MA0622.1	BCACGTGK	Mlxip	2.84e-05	4.59e-08	829	2.85	629	2.15	1.33
338	103	MA1573.2 (Thap11)	STREME-16	16-ACTACATTTCCCAG	16-ACTACATTTCCCAG	Thap11	4.57e-05	7.37e-08	489	1.68	339	1.16	1.45
339	67	MA0688.1	TBX2	MA0688.1	DAGGTGTGAAA	TBX2	0.000179	2.88e-07	9570	32.9	9060	31	1.06
340	25	MA0059.1	MAX::MYC	MA0059.1	RASCACGTGGT	MAX::MYC	0.000275	4.41e-07	8560	29.4	8070	27.6	1.07
341	74	MA0844.1	XBP1	MA0844.1	WDKGMCACGTCATC	XBP1	0.000304	4.86e-07	3780	13	3410	11.6	1.12
342	25	MA0832.1	Tcf21	MA0832.1	RYAACAGCTGTTRN	Tcf21	0.000371	5.91e-07	1610	5.53	1360	4.63	1.19
343	47	MA0761.2	ETV1	MA0761.2	NNACAGGAAGTGNN	ETV1	0.000499	7.93e-07	24300	83.5	24000	82	1.02
344	77	MA1576.1	THRB	MA1576.1	DTGACCTBACGTGACCTYA	THRB	0.000504	7.98e-07	2740	9.44	2420	8.29	1.14
345	60	MA0730.1	RARA	MA0730.1	AGGTCAHSYAAAGGTCA	RARA	0.000547	8.65e-07	137	0.47	68	0.23	2.01
346	98	MA1523.1	MSANTD3	MA1523.1	STVCACTCAC	MSANTD3	0.000679	1.07e-06	10100	34.6	9570	32.7	1.06
347	104	MA1557.1	SMAD5	MA1557.1	YGTCTAGACA	SMAD5	0.00149	2.34e-06	7010	24.1	6580	22.5	1.07
348	75	MA0691.1	TFAP4	MA0691.1	AWCAGCTGWT	TFAP4	0.00156	2.44e-06	3410	11.7	3070	10.5	1.11
349	48	MA0735.1	GLIS1	MA0735.1	MGACCCCCCACGAWGC	GLIS1	0.0021	3.28e-06	91	0.31	39	0.13	2.31
350	25	MA1467.2	Atoh1	MA1467.2	RVCAGATGGYN	Atoh1	0.00267	4.17e-06	26400	90.8	26300	89.7	1.01
351	85	MA0510.2	RFX5	MA0510.2	SGTTGCCATGGYAACV	RFX5	0.006	9.32e-06	50	0.17	15	0.05	3.21
352	105	MA0083.3	SRF	MA0083.3	TGMCCATATATGGKCA	SRF	0.0296	4.59e-05	355	1.22	258	0.88	1.38
353	77	MA0860.1	Rarg	MA0860.1	AAGGTCAMSARAGGTCA	Rarg	0.0301	4.65e-05	93	0.32	46	0.16	2.01
354	25	MA0526.4	USF2	MA0526.4	DRTCACGTGAYH	USF2	0.0335	5.16e-05	292	1	205	0.7	1.43
355	106	MA1998.1	Prdm14	MA1998.1	NDGGTCTCTAWS	Prdm14	0.0343	5.26e-05	24200	83.2	24000	82	1.02
356	47	MA1936.1	ERF::FOXO1	MA1936.1	RTMAACAGGAARBS	ERF::FOXO1	0.0396	6.06e-05	17700	60.7	17300	59.1	1.03
357	76	MA1939.1	ERF::SREBF2	MA1939.1	NSCGGAARTCACGTGAT	ERF::SREBF2	0.0489	7.48e-05	2960	10.2	2700	9.24	1.1
18	107	MA1125.1 (ZNF384)	MEME-2	AAAAAAAAAAAAAAA	AAAAAAAAAAAAAAA	ZNF384	18	1	173	0.59	253	0.86	0.689

ER_rat <- 1.25

DOX_sigdown_24hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DOX_sigdown_24hr response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DOX_sigdown_24hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.75), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.75,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste(" DOX_sigdown_24hr response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DOX_DAR 24 2kb data

DOX_242kb_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_2kb_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DOX_242kb_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_2kb_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DOX_242kb_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_2kb_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DOX_242kb_sea_all <- rbind(DOX_242kb_sea_disc, DOX_242kb_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DOX_242kb_combo <- DOX_242kb_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DOX_242kb_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

DOX_242kb_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in DOX_24 2kb") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in DOX_24 2kb
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	1.84e-120	6.35e-121	1400	11.3	889	4.33	2.61
2	1	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	9.25e-120	1.59e-120	1300	10.5	784	3.82	2.74
3	1	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	3.61e-119	4.14e-120	1530	12.4	1040	5.06	2.44
4	1	MA1134.1 (FOS::JUNB)	STREME-1	1-GATGASTCATC	GATGASTCATC	FOS::JUNB	3.12e-117	2.68e-118	1420	11.4	919	4.48	2.55
5	1	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	2.2e-116	1.51e-117	1370	11.1	878	4.28	2.59
6	1	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	4.1e-115	2.35e-116	1260	10.2	769	3.75	2.72
7	1	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	5.56e-114	2.73e-115	1570	12.7	1110	5.41	2.35
8	1	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	9.92e-111	4.27e-112	1620	13.1	1180	5.77	2.27
9	1	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	1.27e-110	4.87e-112	1330	10.7	859	4.18	2.56
10	1	MA0476.1 (FOS)	MEME-2	ATGASTCASHN	ATGASTCASHN	FOS	7.52e-110	2.59e-111	1100	8.86	623	3.03	2.92
11	1	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	1.11e-106	3.47e-108	1250	10	788	3.84	2.62
12	1	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	3.98e-106	1.14e-107	1780	14.3	1390	6.75	2.12
13	1	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	9.81e-106	2.6e-107	1920	15.5	1560	7.61	2.03
14	1	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	1.97e-105	4.83e-107	1050	8.48	594	2.89	2.93
15	1	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	2.97e-103	6.82e-105	1070	8.61	619	3.02	2.85
16	1	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	5.54e-103	1.19e-104	2020	16.2	1700	8.26	1.97
17	1	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	9.74e-103	1.87e-104	1970	15.9	1650	8.02	1.98
18	1	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	9.77e-103	1.87e-104	2100	17	1810	8.81	1.93
19	1	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	1.25e-100	2.26e-102	975	7.86	537	2.62	3
20	1	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	2.42e-100	4.17e-102	1700	13.7	1330	6.48	2.11
21	1	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	2.69e-100	4.41e-102	1910	15.4	1580	7.72	1.99
22	1	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	2.17e-97	3.4e-99	1010	8.16	587	2.86	2.85
23	1	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	3.93e-94	5.89e-96	1920	15.5	1640	7.99	1.94
24	1	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	4.85e-92	6.95e-94	1360	11	991	4.83	2.28
25	1	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	8.77e-92	1.21e-93	1470	11.9	1120	5.43	2.18
26	1	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	2.03e-87	2.69e-89	1100	8.91	729	3.55	2.51
27	1	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	1.41e-72	1.79e-74	2390	19.2	2420	11.8	1.63
28	1	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	2.33e-71	2.87e-73	3090	24.9	3410	16.6	1.5
29	1	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	2.72e-53	3.22e-55	4540	36.6	5800	28.3	1.3
30	1	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	7.04e-51	8.07e-53	2330	18.8	2560	12.5	1.51
31	1	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	2.32e-48	2.58e-50	1180	9.51	1060	5.14	1.85
32	2	MA0710.1	NOTO	MA0710.1	NYTAATTAVN	NOTO	3.82e-46	4.11e-48	8210	66.2	11900	58	1.14
33	2	MA0885.2	Dlx2	MA0885.2	NDGCAATTAGNN	Dlx2	1.24e-45	1.29e-47	9230	74.4	13700	66.8	1.11
34	3	3-AKKMMT	STREME-3	3-AKKMMT	AKKMMT	AKKMMT	9.78e-45	9.89e-47	5720	46.2	7810	38	1.21
35	2	MA0718.1	RAX	MA0718.1	RYYAATTARH	RAX	1.19e-44	1.17e-46	8030	64.7	11600	56.7	1.14
36	2	MA1476.2	Dlx5	MA1476.2	NDGCAATTAGNN	Dlx5	3.6e-44	3.44e-46	8720	70.3	12800	62.6	1.12
37	2	MA0644.2	ESX1	MA0644.2	YYAATTAN	ESX1	1.38e-43	1.28e-45	8570	69.1	12600	61.4	1.13
38	2	MA0726.1	VSX2	MA0726.1	CTAATTAN	VSX2	2.02e-43	1.83e-45	8980	72.4	13300	64.9	1.12
39	1	MA0150.2	Nfe2l2	MA0150.2	CASNATGACTCAGCA	Nfe2l2	7.32e-43	6.46e-45	4280	34.5	5560	27.1	1.27
40	2	MA1963.1	SATB1	MA1963.1	WWDCTAATAAHWW	SATB1	9.65e-43	8.3e-45	6960	56.1	9870	48.1	1.17
41	4	MA0142.1	Pou5f1::Sox2	MA0142.1	CWTTGTYATGCAAAT	Pou5f1::Sox2	1.45e-42	1.22e-44	8260	66.6	12100	58.8	1.13
42	2	MA0720.1	Shox2	MA0720.1	YYAATTAR	Shox2	1.17e-41	9.57e-44	8820	71.1	13100	63.6	1.12
43	5	5-ATTGAG	STREME-5	5-ATTGAG	ATTGAG	ATTGAG	1.93e-41	1.54e-43	9490	76.5	14300	69.5	1.1
44	2	MA0666.2	MSX1	MA0666.2	SCAATTAR	MSX1	8.62e-41	6.74e-43	6980	56.3	9940	48.4	1.16
45	1	MA1639.1	MEIS1	MA1639.1	NHCATMAATCAHN	MEIS1	1.12e-40	8.55e-43	8730	70.4	12900	63	1.12
46	2	MA0681.2	PHOX2B	MA0681.2	WWTAATCAAATTAWWW	PHOX2B	1.75e-40	1.3e-42	5650	45.6	7770	37.8	1.2
47	2	MA0654.1	ISX	MA0654.1	YYAATTAR	ISX	1.77e-40	1.3e-42	6050	48.8	8410	41	1.19
48	2	MA0680.2	Pax7	MA0680.2	DWTAATCAATTAWNH	Pax7	2.39e-40	1.71e-42	6860	55.3	9760	47.5	1.16
49	6	MA0498.2 (MEIS1)	STREME-4	4-YTGWCAR	YTGWCAR	MEIS1	3.43e-40	2.41e-42	9260	74.6	13900	67.5	1.11
50	2	MA0628.1	POU6F1	MA0628.1	AYTAATTART	POU6F1	4.32e-40	2.97e-42	6820	55	9680	47.2	1.17
51	1	MA1113.2	PBX2	MA1113.2	NHCATAAATCAHN	PBX2	5.11e-40	3.45e-42	8070	65.1	11800	57.5	1.13
52	2	MA0700.2	LHX2	MA0700.2	DDCCAATTADN	LHX2	1.41e-39	9.34e-42	8000	64.5	11700	56.9	1.13
53	7	MA1104.2	GATA6	MA1104.2	HWWTCTTATCTNH	GATA6	1.68e-39	1.09e-41	6440	52	9080	44.2	1.17
54	4	MA0789.1	POU3F4	MA0789.1	TATGCWAAT	POU3F4	2.59e-39	1.65e-41	7190	58	10300	50.3	1.15
55	8	MA0790.1	POU4F1	MA0790.1	ATGMATAATTAATG	POU4F1	2.82e-39	1.75e-41	7230	58.3	10400	50.6	1.15
56	2	MA0717.1	RAX2	MA0717.1	YYAATTAV	RAX2	2.86e-39	1.75e-41	8370	67.5	12300	60	1.12
57	2	MA0787.1	POU3F2	MA0787.1	WTATGCWAATKA	POU3F2	2.89e-39	1.75e-41	6540	52.7	9230	45	1.17
58	2	MA0027.2	EN1	MA0027.2	SYAATTAV	EN1	3.05e-39	1.81e-41	8540	68.9	12600	61.5	1.12
59	2	MA0704.1	Lhx4	MA0704.1	YTAATTAR	Lhx4	3.46e-39	2.02e-41	8400	67.7	12400	60.3	1.12
60	8	MA0791.1	POU4F3	MA0791.1	RTGMATWATTAATGAR	POU4F3	3.97e-39	2.28e-41	6640	53.5	9400	45.8	1.17
61	9	MA0676.1	Nr2e1	MA0676.1	AAAAGTCAA	Nr2e1	2.17e-38	1.22e-40	9510	76.6	14300	69.9	1.1
62	2	MA0725.1	VSX1	MA0725.1	YTAATTAN	VSX1	2.82e-38	1.56e-40	9700	78.2	14700	71.6	1.09
63	10	MA0896.1	Hmx1	MA0896.1	VSVAGCAATTAAWGVDB	Hmx1	4.11e-38	2.25e-40	6480	52.2	9160	44.6	1.17
64	11	MA0495.3	MAFF	MA0495.3	DWGTCAGCATTTTWHN	MAFF	1.4e-37	7.53e-40	4940	39.8	6690	32.6	1.22
65	2	MA0889.1	GBX1	MA0889.1	VCYAATTASY	GBX1	1.47e-37	7.78e-40	8010	64.5	11700	57.2	1.13
66	2	MA0722.1	VAX1	MA0722.1	YTAATTAH	VAX1	1.83e-37	9.52e-40	9180	74	13800	67.1	1.1
67	2	MA0886.1	EMX2	MA0886.1	VBTAATTARB	EMX2	2.24e-37	1.15e-39	6530	52.6	9260	45.1	1.17
68	1	MA1640.1	MEIS2	MA1640.1	NNATGATTTATGDNH	MEIS2	3.98e-37	2.01e-39	7220	58.2	10400	50.8	1.15
69	7	MA0036.3	GATA2	MA0036.3	NBCTTATCTNH	GATA2	4.85e-37	2.42e-39	4850	39.1	6560	31.9	1.22
70	2	MA0674.1	NKX6-1	MA0674.1	NTMATTAA	NKX6-1	5.14e-37	2.52e-39	9730	78.5	14800	72	1.09
71	4	MA1115.1	POU5F1	MA1115.1	WHATGCAAATN	POU5F1	7.12e-37	3.45e-39	8190	66	12100	58.8	1.12
72	2	MA0675.1	NKX6-2	MA0675.1	NYMATTAA	NKX6-2	8.92e-37	4.26e-39	9060	73	13600	66.1	1.1
73	2	MA0661.1	MEOX1	MA0661.1	VSTAATTAHC	MEOX1	1.59e-36	7.49e-39	8190	66	12100	58.8	1.12
74	2	MA1519.1	LHX5	MA1519.1	STAATTAV	LHX5	2.66e-36	1.23e-38	3910	31.5	5100	24.9	1.27
75	2	MA0125.1	Nobox	MA0125.1	TAATTRSY	Nobox	3.53e-36	1.62e-38	7670	61.8	11200	54.5	1.13
76	10	MA0122.3	Nkx3-2	MA0122.3	WWAAMCACTTAAN	Nkx3-2	4.01e-36	1.82e-38	9230	74.4	13900	67.6	1.1
77	12	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	5.62e-36	2.51e-38	5820	46.9	8130	39.6	1.18
78	2	MA0721.1	UNCX	MA0721.1	YYAATTAV	UNCX	1.17e-35	5.18e-38	8820	71.1	13200	64.2	1.11
79	10	MA0650.3	Hoxa13	MA0650.3	NNCCAATAAAAN	Hoxa13	1.92e-35	8.35e-38	8640	69.6	12900	62.6	1.11
80	13	MA0025.2	NFIL3	MA0025.2	NRTTATGYAATNN	NFIL3	1.97e-35	8.46e-38	7250	58.4	10500	51.1	1.14
81	14	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	2.91e-35	1.24e-37	7690	62	11200	54.7	1.13
82	2	MA0879.2	DLX1	MA0879.2	VYAATTAN	DLX1	3.35e-35	1.41e-37	9640	77.7	14600	71.3	1.09
83	10	MA0041.2	FOXD3	MA0041.2	WAWGHAAATAAACARY	FOXD3	3.53e-35	1.46e-37	8870	71.5	13300	64.6	1.11
84	2	MA1505.1	HOXC8	MA1505.1	KTAATTAM	HOXC8	3.66e-35	1.5e-37	4220	34	5600	27.3	1.25
85	15	MA0052.4	MEF2A	MA0052.4	DDCTAAAAATAGMHH	MEF2A	4.31e-35	1.75e-37	7850	63.3	11500	56.1	1.13
86	2	MA0887.1	EVX1	MA0887.1	VVTAATTABS	EVX1	4.61e-35	1.85e-37	9260	74.6	14000	68	1.1
87	16	MA0602.1	Arid5a	MA0602.1	SYAATATTGVDANH	Arid5a	4.91e-35	1.94e-37	8100	65.3	12000	58.2	1.12
88	7	MA0035.4	GATA1	MA0035.4	NHCTAATCTDH	GATA1	6.42e-35	2.51e-37	8220	66.2	12200	59.2	1.12
89	2	MA0903.1	HOXB3	MA0903.1	NNYMATTARN	HOXB3	8.52e-35	3.29e-37	7710	62.1	11300	55	1.13
90	10	MA0679.2	ONECUT1	MA0679.2	WAAAAATCAATAAWWN	ONECUT1	9.09e-35	3.48e-37	6150	49.6	8690	42.3	1.17
91	2	MA0890.1	GBX2	MA0890.1	RSYAATTARN	GBX2	1.21e-34	4.57e-37	8340	67.2	12400	60.2	1.12
92	2	MA0713.1	PHOX2A	MA0713.1	TAATYYAATTA	PHOX2A	1.89e-34	7.07e-37	7140	57.6	10300	50.4	1.14
93	2	MA0902.2	HOXB2	MA0902.2	SYAATTAS	HOXB2	3.4e-34	1.26e-36	6130	49.4	8680	42.3	1.17
94	2	MA0793.1	POU6F2	MA0793.1	ASCTMATTAW	POU6F2	5.25e-34	1.92e-36	7720	62.3	11300	55.2	1.13
95	2	MA0716.1	PRRX1	MA0716.1	YYAATTAR	PRRX1	1.34e-33	4.85e-36	9050	73	13600	66.4	1.1
96	2	MA1502.1	HOXB8	MA1502.1	GYMATTAM	HOXB8	1.41e-33	5.04e-36	5680	45.8	7960	38.8	1.18
97	2	MA0788.1	POU3F3	MA0788.1	WWTATGCWAATTW	POU3F3	1.53e-33	5.42e-36	6280	50.6	8930	43.5	1.16
98	2	MA0642.2	EN2	MA0642.2	VSYAATTA	EN2	2.05e-33	7.2e-36	7990	64.4	11800	57.5	1.12
99	2	MA0630.1	SHOX	MA0630.1	HTAATTRR	SHOX	2.34e-33	8.15e-36	9640	77.7	14700	71.5	1.09
100	17	MA0029.1 (Mecom)	STREME-2	2-AGATAAT	AGATAAT	Mecom	2.92e-33	1e-35	4180	33.7	5580	27.2	1.24
101	2	MA0068.2	PAX4	MA0068.2	CTAATTAG	PAX4	3.97e-33	1.35e-35	6930	55.9	10000	48.8	1.15
102	12	MA0032.2	FOXC1	MA0032.2	WAWGTAAAYAW	FOXC1	5.16e-33	1.74e-35	8280	66.8	12300	59.9	1.11
103	18	MA1562.1	SOX14	MA1562.1	CCGAACAATG	SOX14	5.33e-33	1.78e-35	8700	70.1	13000	63.4	1.11
104	2	MA0648.1	GSC	MA0648.1	VYTAATCCSY	GSC	6.18e-33	2.04e-35	7490	60.4	11000	53.4	1.13
105	10	MA0898.1	Hmx3	MA0898.1	ASAAGCAATTAAWRRAT	Hmx3	6.24e-33	2.04e-35	5740	46.2	8060	39.2	1.18
106	2	MA0853.1	Alx4	MA0853.1	CGCRYTAATTARYHNNY	Alx4	6.47e-33	2.1e-35	5020	40.5	6900	33.6	1.2
107	2	MA0888.1	EVX2	MA0888.1	VVTAATTAVB	EVX2	7.37e-33	2.37e-35	9000	72.6	13600	66	1.1
108	18	MA0084.1	SRY	MA0084.1	NWWAACAAT	SRY	9.34e-33	2.98e-35	9540	76.9	14500	70.7	1.09
109	10	MA0909.3	Hoxd13	MA0909.3	NNCAATAAAW	Hoxd13	9.91e-33	3.13e-35	6380	51.5	9120	44.4	1.16
110	12	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	1.43e-32	4.49e-35	7280	58.7	10600	51.7	1.14
111	18	MA0077.1	SOX9	MA0077.1	CYATTGTTY	SOX9	1.69e-32	5.24e-35	6040	48.7	8560	41.7	1.17
112	2	MA1463.1	ARGFX	MA1463.1	DCTAATTARM	ARGFX	2.97e-32	9.12e-35	4500	36.2	6090	29.7	1.22
113	2	MA0892.1	GSX1	MA0892.1	NCYMATTAVN	GSX1	4.42e-32	1.34e-34	7260	58.5	10600	51.6	1.13
114	2	MA0891.1	GSC2	MA0891.1	NYTAATCCBH	GSC2	5.14e-32	1.55e-34	8930	72	13500	65.5	1.1
115	2	MA0881.1	Dlx4	MA0881.1	VYAATTAN	Dlx4	5.43e-32	1.62e-34	9950	80.2	15300	74.4	1.08
116	2	MA0706.1	MEOX2	MA0706.1	DSTAATTAWN	MEOX2	6.17e-32	1.82e-34	9360	75.4	14200	69.2	1.09
117	19	10-TAASCA	STREME-10	10-TAASCA	10-TAASCA	TAASCA	6.19e-32	1.82e-34	8220	66.2	12200	59.5	1.11
118	2	MA0882.1	DLX6	MA0882.1	VYAATTAN	DLX6	6.7e-32	1.95e-34	10300	82.9	15900	77.4	1.07
119	20	MA0769.2	TCF7	MA0769.2	NNCTTTGAWVT	TCF7	6.79e-32	1.96e-34	9100	73.4	13800	67	1.1
120	8	MA0046.2	HNF1A	MA0046.2	DRTTAATNATTAACN	HNF1A	7.88e-32	2.26e-34	4600	37.1	6270	30.6	1.22
121	10	MA0901.2	HOXB13	MA0901.2	WDCCAATAAAAWWW	HOXB13	8.86e-32	2.52e-34	6880	55.4	9950	48.5	1.14
122	2	MA1498.2	HOXA7	MA1498.2	SYMATTAV	HOXA7	1.01e-31	2.86e-34	8540	68.8	12800	62.2	1.11
123	21	MA0611.2	Dux	MA0611.2	NTGATTBAATCAVWNN	Dux	1.05e-31	2.91e-34	3580	28.9	4680	22.8	1.27
124	2	MA0900.2	HOXA2	MA0900.2	STAATTAS	HOXA2	1.05e-31	2.91e-34	3580	28.9	4680	22.8	1.27
125	2	MA1518.2	Lhx1	MA1518.2	NNNTGCTAATTAGCANNN	Lhx1	1.5e-31	4.12e-34	8350	67.3	12400	60.6	1.11
126	2	MA0701.2	LHX9	MA0701.2	CYAATTAR	LHX9	2.67e-31	7.28e-34	3480	28.1	4540	22.1	1.27
127	2	MA0709.1	Msx3	MA0709.1	SCAATTAN	Msx3	3.07e-31	8.33e-34	8800	71	13200	64.5	1.1
128	4	MA0627.2	POU2F3	MA0627.2	NWTATGCAAATNH	POU2F3	3.52e-31	9.47e-34	6000	48.4	8520	41.5	1.17
129	18	MA0078.2	Sox17	MA0078.2	NNAGAACAATGGNN	Sox17	3.91e-31	1.04e-33	8900	71.7	13400	65.3	1.1
130	22	MA1480.1	DPRX	MA1480.1	AGATAATCCN	DPRX	4.09e-31	1.08e-33	8590	69.3	12900	62.7	1.1
131	7	MA1970.1	TRPS1	MA1970.1	NHTCTTATCTNH	TRPS1	4.37e-31	1.15e-33	4880	39.3	6720	32.7	1.2
132	2	MA0708.2	MSX2	MA0708.2	SCAATTAV	MSX2	5.17e-31	1.35e-33	7120	57.4	10400	50.6	1.14
133	2	MA0854.1	Alx1	MA0854.1	CGMRYTAATTARTNMNY	Alx1	6.84e-31	1.77e-33	4430	35.7	6020	29.3	1.22
134	2	MA1549.1	POU6F1	MA1549.1	RTAATGAGVN	POU6F1	7.21e-31	1.85e-33	5090	41	7050	34.4	1.19
135	2	MA0880.1	Dlx3	MA0880.1	NYAATTAN	Dlx3	7.65e-31	1.95e-33	10400	83.8	16100	78.4	1.07
136	2	MA1471.1	BARX2	MA1471.1	NWWAAYMATTAN	BARX2	8.1e-31	2.05e-33	7120	57.4	10400	50.6	1.14
137	8	MA0153.2	HNF1B	MA0153.2	GTTAATNATTAAY	HNF1B	1.19e-30	2.99e-33	3770	30.4	4990	24.3	1.25
138	7	MA0037.4	Gata3	MA0037.4	NHTCTTATCTNH	Gata3	1.25e-30	3.11e-33	5800	46.7	8200	40	1.17
139	23	MA0905.1	HOXC10	MA0905.1	GTCRTAAAAH	HOXC10	1.38e-30	3.41e-33	7800	62.9	11500	56.2	1.12
140	2	MA1530.1	NKX6-3	MA1530.1	VYCATTAWW	NKX6-3	1.58e-30	3.89e-33	5860	47.2	8310	40.5	1.17
141	4	MA0792.1	POU5F1B	MA0792.1	TATGCWAAT	POU5F1B	1.84e-30	4.49e-33	9500	76.6	14500	70.6	1.09
142	22	MA0711.1	OTX1	MA0711.1	HTAATCCS	OTX1	2.01e-30	4.87e-33	8510	68.6	12800	62.1	1.1
143	2	MA0904.2	HOXB5	MA0904.2	STAATTAS	HOXB5	2.14e-30	5.15e-33	6790	54.7	9840	47.9	1.14
144	24	MA1487.2	FOXE1	MA1487.2	VYTAAAYAAACAAH	FOXE1	3.1e-30	7.4e-33	6360	51.2	9130	44.4	1.15
145	2	MA0634.1	ALX3	MA0634.1	YYYAATTANV	ALX3	4.71e-30	1.12e-32	10400	83.5	16000	78.1	1.07
146	4	MA0786.1	POU3F1	MA0786.1	WTATGCWAATKW	POU3F1	5.86e-30	1.38e-32	4530	36.5	6190	30.1	1.21
147	2	MA0699.1	LBX2	MA0699.1	NCYAATTARN	LBX2	6.07e-30	1.42e-32	9160	73.8	13900	67.7	1.09
148	2	MA0612.2	EMX1	MA0612.2	BTAATTAS	EMX1	6.99e-30	1.63e-32	4410	35.6	6000	29.2	1.22
149	2	MA0635.1	BARHL2	MA0635.1	VHTAAAYGRT	BARHL2	9.63e-30	2.22e-32	8600	69.4	12900	63	1.1
150	2	MA0912.2	HOXD3	MA0912.2	CTAATTAC	HOXD3	1.02e-29	2.34e-32	3800	30.7	5060	24.7	1.24
151	12	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	1.34e-29	3.05e-32	8190	66	12200	59.5	1.11
152	2	MA0662.1	MIXL1	MA0662.1	NBYAATTAVN	MIXL1	1.38e-29	3.11e-32	9770	78.7	15000	73	1.08
153	2	MA0707.2	MNX1	MA0707.2	VYRATTAK	MNX1	1.78e-29	4.01e-32	5830	47	8280	40.4	1.16
154	4	MA0785.1	POU2F1	MA0785.1	AWTATGCWAATK	POU2F1	2e-29	4.47e-32	8460	68.2	12700	61.8	1.1
155	2	MA1608.1	Isl1	MA1608.1	NNCCATTAGNN	Isl1	2.58e-29	5.73e-32	7420	59.8	10900	53.2	1.12
156	10	MA0914.1	ISL2	MA0914.1	GCAMTTAR	ISL2	3.7e-29	8.15e-32	7870	63.4	11700	56.9	1.12
157	2	MA0715.1	PROP1	MA0715.1	TAATYWAATTA	PROP1	4.48e-29	9.82e-32	4180	33.7	5660	27.6	1.22
158	12	MA0148.4	FOXA1	MA0148.4	WWGTAAACATNN	FOXA1	4.64e-29	1.01e-31	9390	75.7	14300	69.7	1.09
159	2	MA0910.2	HOXD8	MA0910.2	GYMATTAM	HOXD8	4.68e-29	1.01e-31	5350	43.1	7520	36.6	1.18
160	22	MA0712.2	OTX2	MA0712.2	NDRGGATTARNN	OTX2	5.42e-29	1.17e-31	7440	60	11000	53.4	1.12
161	25	7-TCACAG	STREME-7	7-TCACAG	TCACAG	TCACAG	8.74e-29	1.87e-31	10600	85.8	16600	80.8	1.06
162	18	MA1152.1	SOX15	MA1152.1	CYWTTGTTHW	SOX15	9.43e-29	2e-31	6810	54.9	9910	48.3	1.14
163	2	MA0705.1	Lhx8	MA0705.1	CTAATTAV	Lhx8	1.11e-28	2.35e-31	6020	48.5	8610	42	1.16
164	2	MA1497.1	HOXA6	MA1497.1	BGYMATTANN	HOXA6	1.42e-28	2.99e-31	9730	78.5	14900	72.8	1.08
165	13	MA1636.1	CEBPG	MA1636.1	NDATGATGCAATMHH	CEBPG	2.42e-28	5.04e-31	8280	66.8	12400	60.4	1.11
166	2	MA0894.1	HESX1	MA0894.1	GHTAATTRRH	HESX1	2.79e-28	5.78e-31	6120	49.3	8780	42.8	1.15
167	12	MA0047.3	FOXA2	MA0047.3	RWGTAAACANN	FOXA2	4.52e-28	9.32e-31	6820	55	9940	48.4	1.14
168	18	MA1563.2	SOX18	MA1563.2	AACAATDV	SOX18	5.31e-28	1.09e-30	7680	62	11400	55.5	1.12
169	10	MA0897.1	Hmx2	MA0897.1	ASAAGCAATTAAHVVRT	Hmx2	7.08e-28	1.44e-30	4680	37.8	6480	31.6	1.2
170	26	MA0108.2	TBP	MA0108.2	STATAAAWRSVVVBN	TBP	8.13e-28	1.64e-30	6600	53.2	9580	46.6	1.14
171	2	MA1500.1	HOXB6	MA1500.1	BTAATKRC	HOXB6	1.04e-27	2.08e-30	10500	84.8	16400	79.9	1.06
172	2	MA0601.1	Arid3b	MA0601.1	ATATTAATWAN	Arid3b	1.13e-27	2.25e-30	5210	42	7330	35.7	1.18
173	27	MA1124.1	ZNF24	MA1124.1	CATTCATTCATTC	ZNF24	1.97e-27	3.92e-30	5950	48	8520	41.5	1.16
174	2	MA0158.2	HOXA5	MA0158.2	GYMATTAS	HOXA5	2.27e-27	4.48e-30	4630	37.3	6400	31.2	1.2
175	2	MA1501.1	HOXB7	MA1501.1	GGTAATTAVS	HOXB7	3.53e-27	6.93e-30	7570	61	11200	54.6	1.12
176	2	MA0876.1	BSX	MA0876.1	SYVATTAV	BSX	3.81e-27	7.45e-30	7060	56.9	10400	50.5	1.13
177	28	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	6.07e-27	1.18e-29	7410	59.7	11000	53.4	1.12
178	12	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	9.74e-27	1.88e-29	9590	77.3	14700	71.7	1.08
179	2	MA0723.2	VAX2	MA0723.2	BYAATTAV	VAX2	1.08e-26	2.07e-29	10100	81.3	15600	76.1	1.07
180	2	MA1481.1	DRGX	MA1481.1	YYAATTAN	DRGX	1.42e-26	2.71e-29	3580	28.9	4780	23.3	1.24
181	29	MA0755.1	CUX2	MA0755.1	TRATCGATAW	CUX2	1.66e-26	3.16e-29	7100	57.3	10500	50.9	1.12
182	18	MA0868.2	SOX8	MA0868.2	MGAACAATRG	SOX8	2.05e-26	3.88e-29	8980	72.4	13700	66.5	1.09
183	18	MA0143.4	SOX2	MA0143.4	DNACAATGGNN	SOX2	2.43e-26	4.57e-29	9230	74.4	14100	68.7	1.08
184	2	MA0875.1	BARX1	MA0875.1	VCMATTAV	BARX1	2.94e-26	5.49e-29	7040	56.7	10300	50.4	1.13
185	24	MA0847.3	FOXD2	MA0847.3	SYTAARYAAACA	FOXD2	7.62e-26	1.42e-28	5600	45.2	8000	39	1.16
186	30	MA0018.4	CREB1	MA0018.4	NNRTGATGTCAYN	CREB1	1.15e-25	2.13e-28	5670	45.7	8110	39.5	1.16
187	21	MA1720.1	ZNF85	MA1720.1	DHDGAGATTACWKCAK	ZNF85	1.25e-25	2.3e-28	7160	57.7	10600	51.4	1.12
188	15	MA0497.1	MEF2C	MA0497.1	DDDCYAAAAATAGMW	MEF2C	1.47e-25	2.68e-28	5380	43.3	7640	37.2	1.17
189	31	MA0809.2	TEAD4	MA0809.2	NNACATTCCARN	TEAD4	2.3e-25	4.18e-28	9700	78.2	14900	72.8	1.07
190	2	MA0658.1	LHX6	MA0658.1	RCTAATTARY	LHX6	2.94e-25	5.33e-28	4720	38.1	6600	32.2	1.18
191	2	MA0075.3	PRRX2	MA0075.3	CTAATTAN	PRRX2	3.22e-25	5.8e-28	3700	29.8	4980	24.3	1.23
192	18	MA1120.1	SOX13	MA1120.1	DVACAATGGNN	SOX13	6.22e-25	1.11e-27	9150	73.8	14000	68.1	1.08
193	12	MA1607.1	Foxl2	MA1607.1	DDWATGTAAACANN	Foxl2	6.4e-25	1.14e-27	7100	57.3	10500	51.1	1.12
194	2	MA1499.1	HOXB4	MA1499.1	RTMATTAR	HOXB4	7.53e-25	1.33e-27	5520	44.5	7880	38.4	1.16
195	10	MA0899.1	HOXA10	MA0899.1	DGYMATAAAAH	HOXA10	9.69e-25	1.71e-27	9520	76.8	14600	71.3	1.08
196	32	MA1974.1	ZNF211	MA1974.1	HWYATATACCAYRYW	ZNF211	1.06e-24	1.87e-27	5020	40.4	7080	34.5	1.17
197	33	MA0483.1	Gfi1B	MA0483.1	AAATCWCWGCH	Gfi1B	2.44e-24	4.25e-27	4790	38.6	6720	32.8	1.18
198	18	MA0514.2	Sox3	MA0514.2	DNACAATGGNN	Sox3	2.65e-24	4.6e-27	10100	81.7	15700	76.7	1.06
199	22	MA0714.1	PITX3	MA0714.1	NYTAATCCC	PITX3	2.74e-24	4.73e-27	8900	71.8	13600	66.1	1.09
200	34	MA0144.2	STAT3	MA0144.2	YTTCYKGGAAD	STAT3	2.75e-24	4.73e-27	6190	49.9	8990	43.8	1.14
201	12	MA0850.1	FOXP3	MA0850.1	RTAAACA	FOXP3	5.6e-24	9.59e-27	8640	69.7	13100	64	1.09
202	35	MA1657.1	ZNF652	MA1657.1	BAAAGRGTTAAN	ZNF652	6.42e-24	1.09e-26	7730	62.3	11600	56.4	1.11
203	13	MA0102.4	CEBPA	MA0102.4	NDATTGCACAATHN	CEBPA	8.79e-24	1.49e-26	8900	71.8	13600	66.1	1.08
204	36	MA0877.3	BARHL1	MA0877.3	AMCGTTTA	BARHL1	9.22e-24	1.56e-26	9220	74.3	14100	68.8	1.08
205	12	MA0481.3	FOXP1	MA0481.3	NDGTAAACANH	FOXP1	1.35e-23	2.27e-26	9950	80.2	15400	75.2	1.07
206	22	MA0682.2	PITX1	MA0682.2	YTAATCCH	PITX1	1.53e-23	2.55e-26	5420	43.7	7750	37.8	1.16
207	2	MA1504.1	HOXC4	MA1504.1	VTMATTAN	HOXC4	2.14e-23	3.56e-26	6280	50.6	9160	44.6	1.13
208	37	MA0052.4 (MEF2A)	MEME-1	WWDKWTTKTWTTTTW	WWDKWTTKTWTTTTW	MEF2A	4.02e-23	6.66e-26	4140	33.4	5730	27.9	1.2
209	10	MA0883.1	Dmbx1	MA0883.1	WDRWNMGGATTADKNNW	Dmbx1	4.28e-23	7.04e-26	4810	38.8	6780	33	1.17
210	7	MA0482.2	GATA4	MA0482.2	NNCCTTATCTNH	GATA4	8.9e-23	1.46e-25	2090	16.9	2600	12.7	1.33
211	10	MA0151.1	Arid3a	MA0151.1	ATYAAA	Arid3a	1.03e-22	1.68e-25	4320	34.8	6010	29.3	1.19
212	2	MA1577.1	TLX2	MA1577.1	BYAATTAR	TLX2	1.14e-22	1.85e-25	3050	24.6	4040	19.7	1.25
213	2	MA0874.1	Arx	MA0874.1	VTBCRYTAATTARTKSW	Arx	1.17e-22	1.88e-25	3840	30.9	5260	25.6	1.21
214	38	MA0050.3	Irf1	MA0050.3	ANTGAAACTGAAASH	Irf1	1.24e-22	2e-25	8040	64.8	12100	59.1	1.1
215	12	MA0031.1	FOXD1	MA0031.1	GTAAACAW	FOXD1	1.74e-22	2.78e-25	6040	48.7	8800	42.8	1.14
216	2	MA0895.1	HMBOX1	MA0895.1	MYTAGTTAMS	HMBOX1	1.92e-22	3.05e-25	8760	70.6	13400	65.1	1.08
217	2	MA0893.2	GSX2	MA0893.2	SYMATTAR	GSX2	3.05e-22	4.84e-25	6290	50.7	9210	44.9	1.13
218	20	MA0523.1	TCF7L2	MA0523.1	DRASATCAAAGRVA	TCF7L2	3.67e-22	5.79e-25	4400	35.5	6160	30	1.18
219	10	MA0070.1	PBX1	MA0070.1	HCATCAATCAAW	PBX1	3.87e-22	6.07e-25	4640	37.4	6540	31.8	1.17
220	2	MA1495.1	HOXA1	MA1495.1	STAATTAS	HOXA1	4.41e-22	6.9e-25	7000	56.4	10400	50.6	1.12
221	31	MA1121.1	TEAD2	MA1121.1	NYACATTCCWNNS	TEAD2	6.66e-22	1.04e-24	8420	67.9	12800	62.3	1.09
222	12	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	7.01e-22	1.09e-24	7190	57.9	10700	52.2	1.11
223	20	MA0768.2	Lef1	MA0768.2	NNBCCTTTGATSTN	Lef1	8.81e-22	1.36e-24	10100	81.6	15800	76.9	1.06
224	2	MA0467.2	Crx	MA0467.2	NDGGATTANN	Crx	9.41e-22	1.45e-24	6110	49.2	8920	43.5	1.13
225	12	MA0157.3	Foxo3	MA0157.3	NDGTAAACARNN	Foxo3	1.12e-21	1.71e-24	10100	81.3	15700	76.6	1.06
226	12	MA1103.2	FOXK2	MA1103.2	DDGTAAACANN	FOXK2	1.18e-21	1.8e-24	9660	77.9	15000	72.9	1.07
227	12	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	1.57e-21	2.38e-24	9270	74.7	14300	69.5	1.07
228	23	MA0911.1	Hoxa11	MA0911.1	RGTCGTAAAANT	Hoxa11	1.59e-21	2.39e-24	7650	61.7	11500	56	1.1
229	12	MA0480.2	Foxo1	MA0480.2	NDGTAAACANN	Foxo1	1.82e-21	2.73e-24	9550	77	14800	72	1.07
230	39	MA0052.4 (MEF2A)	STREME-9	9-AAAATA	AAAATA	MEF2A	3.55e-21	5.31e-24	7210	58.1	10800	52.4	1.11
231	40	MA0867.2	SOX4	MA0867.2	RAACAAAGRV	SOX4	4.48e-21	6.68e-24	9340	75.3	14400	70.2	1.07
232	2	MA1960.1	MGA::EVX1	MA1960.1	RGGTGWTAATKD	MGA::EVX1	5.29e-21	7.84e-24	7170	57.8	10700	52.1	1.11
233	13	MA0833.2	ATF4	MA0833.2	DDATGATGCAATMN	ATF4	5.33e-21	7.87e-24	5660	45.7	8220	40	1.14
234	40	MA1603.1	Dmrt1	MA1603.1	GHTACAAAGTADC	Dmrt1	5.59e-21	8.22e-24	5840	47.1	8500	41.4	1.14
235	30	MA1126.1	FOS::JUN	MA1126.1	DRTGACGTCATHNDTN	FOS::JUN	1.18e-20	1.72e-23	5890	47.4	8590	41.8	1.13
236	28	MA1523.1	MSANTD3	MA1523.1	STVCACTCAC	MSANTD3	1.22e-20	1.78e-23	8900	71.8	13700	66.5	1.08
237	41	MA1593.1	ZNF317	MA1593.1	WVACAGCAGAYW	ZNF317	1.24e-20	1.81e-23	8900	71.7	13700	66.5	1.08
238	10	MA0851.1	Foxj3	MA0851.1	NDAADGTAAACAAANNM	Foxj3	1.28e-20	1.85e-23	5380	43.4	7760	37.8	1.15
239	12	MA0852.2	FOXK1	MA0852.2	NRDGTAAACAAGNN	FOXK1	1.72e-20	2.47e-23	7770	62.6	11700	57.1	1.1
240	2	MA0132.2	PDX1	MA0132.2	VYAATTAR	PDX1	2.34e-20	3.35e-23	3040	24.5	4080	19.9	1.23
241	30	MA0093.3	USF1	MA0093.3	NDGTCATGTGACHN	USF1	2.8e-20	3.99e-23	9580	77.3	14900	72.4	1.07
242	12	MA0042.2	FOXI1	MA0042.2	GTAAACA	FOXI1	3.83e-20	5.45e-23	5930	47.8	8670	42.2	1.13
243	13	MA0043.3	HLF	MA0043.3	NNRTTATGCAACHN	HLF	5.95e-20	8.42e-23	5400	43.5	7810	38	1.14
244	42	MA1119.1	SIX2	MA1119.1	NNCTGAAACCTGATMY	SIX2	6.8e-20	9.58e-23	7140	57.6	10700	52	1.11
245	14	MA1114.1	PBX3	MA1114.1	NNNTGAGTGACAGGBNN	PBX3	9.11e-20	1.28e-22	4490	36.2	6360	31	1.17
246	43	MA0461.2	Atoh1	MA0461.2	RMCATATGBY	Atoh1	1.52e-19	2.12e-22	9060	73	14000	68	1.07
247	13	MA0836.2	CEBPD	MA0836.2	NRTTGCACAAYHN	CEBPD	1.73e-19	2.41e-22	7980	64.3	12100	58.9	1.09
248	44	MA0878.3	CDX1	MA0878.3	GGYMATAAAA	CDX1	1.91e-19	2.64e-22	4400	35.4	6220	30.3	1.17
249	34	MA1625.1	Stat5b	MA1625.1	NNNTTCCCAGAANNN	Stat5b	2.93e-19	4.05e-22	9400	75.8	14600	71	1.07
250	31	MA0808.1	TEAD3	MA0808.1	RCATTCCW	TEAD3	3.11e-19	4.27e-22	3590	29	4950	24.1	1.2
251	45	MA1709.1	ZIM3	MA1709.1	RVMAACAGAAACCYM	ZIM3	4.05e-19	5.55e-22	7060	56.9	10600	51.5	1.11
252	12	MA0614.1	Foxj2	MA0614.1	RTAAACAA	Foxj2	4.23e-19	5.78e-22	5290	42.6	7650	37.3	1.14
253	30	MA1143.1	FOSL1::JUND	MA1143.1	RTGACGTMAY	FOSL1::JUND	4.6e-19	6.25e-22	7290	58.8	11000	53.4	1.1
254	2	MA1507.1	HOXD4	MA1507.1	VTMATTAD	HOXD4	8.33e-19	1.13e-21	4800	38.7	6880	33.5	1.15
255	30	MA1112.2	NR4A1	MA1112.2	NNAAAGGTCANN	NR4A1	1.25e-18	1.69e-21	9230	74.4	14300	69.5	1.07
256	45	MA1953.1	FOXO1::ELF1	MA1953.1	RTMAACAGGAAGTN	FOXO1::ELF1	1.57e-18	2.11e-21	8090	65.2	12300	60	1.09
257	46	MA1151.1	RORC	MA1151.1	NWAWNTRGGTCA	RORC	2.03e-18	2.72e-21	9440	76.1	14600	71.4	1.07
258	22	MA0719.1	RHOXF1	MA0719.1	NTRATCCN	RHOXF1	4.23e-18	5.65e-21	8580	69.2	13200	64.2	1.08
259	4	MA1962.1	POU2F1::SOX2	MA1962.1	MATTTRCATMACAATRG	POU2F1::SOX2	4.74e-18	6.29e-21	3240	26.1	4440	21.6	1.21
260	31	MA0090.3	TEAD1	MA0090.3	NNACATTCCAGSN	TEAD1	6.36e-18	8.42e-21	4640	37.4	6650	32.4	1.16
261	47	MA0040.1 (Foxq1)	STREME-6	6-AACAAT	AACAAT	Foxq1	7.1e-18	9.36e-21	9990	80.5	15600	76.2	1.06
262	14	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	8.61e-18	1.13e-20	3980	32.1	5600	27.3	1.18
263	34	MA1624.1	Stat5a	MA1624.1	NTTCCAAGAANH	Stat5a	1.08e-17	1.41e-20	8680	70	13300	65	1.08
264	43	MA1524.2	Msgn1	MA1524.2	VRRRACAAATGGTNNN	Msgn1	1.27e-17	1.66e-20	6310	50.9	9370	45.7	1.11
265	23	MA0907.1	HOXC13	MA0907.1	BCTCGTAAAAH	HOXC13	2.29e-17	2.98e-20	4590	37	6570	32	1.15
266	30	MA1632.1	ATF2	MA1632.1	NNATGABGTCATN	ATF2	2.34e-17	3.03e-20	3810	30.7	5340	26	1.18
267	48	MA1105.2	GRHL2	MA1105.2	NRAACAGGTTYN	GRHL2	3.06e-17	3.94e-20	8900	71.8	13700	67	1.07
268	49	MA1479.1	DMRTC2	MA1479.1	AATTGMTACATT	DMRTC2	3.6e-17	4.62e-20	6060	48.8	8960	43.6	1.12
269	18	MA0087.2	Sox5	MA0087.2	VRVAACAATGGNN	Sox5	3.68e-17	4.71e-20	5770	46.5	8490	41.4	1.12
270	1	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	4.6e-17	5.86e-20	631	5.09	630	3.07	1.66
271	20	MA1991.1	Hnf1A	MA1991.1	NBCCTTTGATSTBN	Hnf1A	5.5e-17	6.99e-20	10600	85.6	16800	81.8	1.05
272	2	MA0618.1	LBX1	MA0618.1	TTAATTAG	LBX1	6.27e-17	7.93e-20	4870	39.3	7040	34.3	1.14
273	45	MA0152.2	Nfatc2	MA0152.2	NNRNAATGGAAANWNH	Nfatc2	1.02e-16	1.29e-19	8650	69.7	13300	64.9	1.07
274	50	MA0606.2	Nfat5	MA0606.2	NNATGGAAAAWN	Nfat5	1.08e-16	1.36e-19	9500	76.5	14800	72.1	1.06
275	2	MA1496.1	HOXA4	MA1496.1	RTMATTAV	HOXA4	1.13e-16	1.41e-19	6890	55.5	10300	50.4	1.1
276	30	MA0829.2	SREBF1	MA0829.2	DNATCACSTGATNH	SREBF1	1.16e-16	1.45e-19	8490	68.4	13100	63.6	1.08
277	51	MA1588.1	ZNF136	MA1588.1	RWATTCTTGGTTGRC	ZNF136	1.28e-16	1.59e-19	4700	37.8	6770	33	1.15
278	10	MA0629.1	Rhox11	MA0629.1	ANKNCGCTGTWAWDVRW	Rhox11	1.39e-16	1.72e-19	8750	70.5	13500	65.7	1.07
279	2	MA0724.1	VENTX	MA0724.1	AMCGATTAR	VENTX	1.5e-16	1.84e-19	2650	21.4	3560	17.4	1.23
280	10	MA0465.2	CDX2	MA0465.2	NDGCAATAAAWN	CDX2	1.68e-16	2.06e-19	3960	31.9	5600	27.3	1.17
281	52	MA1978.1	ZNF354A	MA1978.1	HWAADWATAAATGRAYWAWTT	ZNF354A	2.79e-16	3.41e-19	2060	16.6	2680	13.1	1.27
282	7	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	2.84e-16	3.46e-19	1520	12.2	1870	9.12	1.34
283	46	MA1150.1	RORB	MA1150.1	AWWTRGGTCAH	RORB	4.08e-16	4.97e-19	5770	46.5	8530	41.5	1.12
284	28	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	4.44e-16	5.37e-19	6530	52.6	9780	47.6	1.11
285	30	MA1145.1	FOSL2::JUND	MA1145.1	NNRTGACGTCAYHSN	FOSL2::JUND	7.14e-16	8.62e-19	8260	66.6	12700	61.8	1.08
286	29	MA0754.2	CUX1	MA0754.2	TAATCGATAM	CUX1	2.35e-15	2.82e-18	3270	26.3	4540	22.1	1.19
287	49	MA1478.1	DMRTA2	MA1478.1	AATTGHTACAWT	DMRTA2	3.08e-15	3.69e-18	7910	63.8	12100	59	1.08
288	14	MA0774.1	MEIS2	MA0774.1	TTGACAGS	MEIS2	3.27e-15	3.91e-18	5610	45.2	8280	40.4	1.12
289	53	MA0069.1	PAX6	MA0069.1	TTCACGCWTSANTK	PAX6	3.45e-15	4.11e-18	8740	70.5	13500	65.9	1.07
290	54	MA1125.1	ZNF384	MA1125.1	DNWMAAAAAAAA	ZNF384	5e-15	5.93e-18	4810	38.8	7000	34.1	1.14
291	30	MA0631.1	Six3	MA0631.1	DATRGGGTATCAYNWNT	Six3	5.46e-15	6.46e-18	4910	39.6	7160	34.9	1.13
292	10	MA0124.2	Nkx3-1	MA0124.2	RCCACTTAA	Nkx3-1	6.37e-15	7.51e-18	5790	46.7	8600	41.9	1.12
293	43	MA1618.1	Ptf1a	MA1618.1	NNACAGATGTTNN	Ptf1a	1.81e-13	2.12e-16	11100	89.8	17800	86.8	1.03
294	38	MA1623.1	Stat2	MA1623.1	RGAAACAGAAASH	Stat2	1.95e-13	2.29e-16	9950	80.2	15700	76.4	1.05
295	12	MA0849.1	FOXO6	MA0849.1	GTAAACA	FOXO6	2.16e-13	2.51e-16	6260	50.5	9410	45.8	1.1
296	55	MA1989.1	Bcl11B	MA1989.1	NNAAACCACAARNN	Bcl11B	2.43e-13	2.83e-16	9070	73.1	14200	68.9	1.06
297	56	MA0800.1	EOMES	MA0800.1	RAGGTGTGAAAWN	EOMES	2.96e-13	3.43e-16	7020	56.6	10700	52	1.09
298	23	MA0906.1	HOXC12	MA0906.1	RGTCGTAAAAH	HOXC12	4.23e-13	4.88e-16	3950	31.9	5690	27.7	1.15
299	2	MA0621.1	mix-a	MA0621.1	NDTTAATTAGN	mix-a	5.25e-13	6.04e-16	1790	14.4	2340	11.4	1.27
300	57	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	5.98e-13	6.85e-16	4740	38.2	6950	33.9	1.13
301	58	MA0494.1	Nr1h3::Rxra	MA0494.1	TGACCTNNAGTRACCYYDN	Nr1h3::Rxra	6.64e-13	7.59e-16	9230	74.4	14400	70.3	1.06
302	50	MA0624.2	Nfatc1	MA0624.2	NVATGGAAAAWN	Nfatc1	9.62e-13	1.1e-15	7050	56.8	10700	52.4	1.09
303	13	MA0843.1	TEF	MA0843.1	BRTTACRTAAYM	TEF	1.03e-12	1.17e-15	2620	21.1	3600	17.6	1.2
304	31	MA0114.4	HNF4A	MA0114.4	DNCAAAGTCCANN	HNF4A	1.08e-12	1.22e-15	8310	67	12900	62.7	1.07
305	2	MA0135.1	Lhx3	MA0135.1	WAATTAATTAWYY	Lhx3	1.09e-12	1.23e-15	2040	16.4	2720	13.2	1.24
306	43	MA0678.1	OLIG2	MA0678.1	AMCATATGKT	OLIG2	1.7e-12	1.92e-15	6030	48.6	9060	44.2	1.1
307	59	MA0095.3	Yy1	MA0095.3	NNCAAAATGGCN	Yy1	3.09e-12	3.46e-15	9650	77.8	15200	74	1.05
308	21	MA0884.2	DUXA	MA0884.2	YTRATTWAATYAR	DUXA	3.1e-12	3.47e-15	1730	13.9	2260	11	1.26
309	60	MA0508.3	PRDM1	MA0508.3	YNCTTTCTCTH	PRDM1	3.6e-12	4.01e-15	10200	82.4	16200	79	1.04
310	30	MA1139.1	FOSL2::JUNB	MA1139.1	DATGACGTCATH	FOSL2::JUNB	5.53e-12	6.14e-15	5700	46	8540	41.6	1.1
311	78	MA0502.2	NFYB	MA0502.2	CYCATTGGCCVV	NFYB	9.66e-12	1.07e-14	869	7.01	1020	4.96	1.41
312	61	MA1729.1	ZNF680	MA1729.1	GNCCAAGAAGAATDA	ZNF680	1.64e-11	1.81e-14	5370	43.3	8010	39	1.11
313	62	MA1647.2	Prdm4	MA1647.2	RDNCCTTGAAACYGYYN	Prdm4	1.86e-11	2.04e-14	8330	67.2	12900	63.1	1.07
314	43	MA0827.1	OLIG3	MA0827.1	AMCATATGBY	OLIG3	2.02e-11	2.21e-14	6530	52.7	9930	48.4	1.09
315	2	MA1975.1	ZNF214	MA1975.1	VWTCATCAABGTCCT	ZNF214	3.16e-11	3.45e-14	5340	43.1	7980	38.9	1.11
316	63	MA1977.1	ZNF324	MA1977.1	NNNWRGMAGHYAAGGATGGTT	ZNF324	3.79e-11	4.13e-14	6400	51.6	9710	47.3	1.09
317	29	MA0757.1	ONECUT3	MA0757.1	AAAAAATCRATAAH	ONECUT3	3.96e-11	4.3e-14	3250	26.2	4630	22.5	1.16
318	30	MA1127.1	FOSB::JUN	MA1127.1	GATGACGTCAT	FOSB::JUN	4.2e-11	4.54e-14	5000	40.4	7440	36.2	1.11
319	18	MA1561.1	SOX12	MA1561.1	ACCGAACAATV	SOX12	5.19e-11	5.6e-14	8240	66.4	12800	62.4	1.06
320	20	MA0442.2	SOX10	MA0442.2	NDAACAAAGVN	SOX10	5.22e-11	5.61e-14	4070	32.8	5930	28.9	1.13
321	42	MA2001.1	Six4	MA2001.1	GDAACCTGANH	Six4	8.13e-11	8.71e-14	6380	51.4	9700	47.2	1.09
322	30	MA1129.1	FOSL1::JUN	MA1129.1	ATGACGTCAT	FOSL1::JUN	8.47e-11	9.05e-14	5970	48.1	9020	43.9	1.09
323	56	MA0802.1	TBR1	MA0802.1	AGGTGTGAAA	TBR1	8.62e-11	9.18e-14	9600	77.4	15100	73.8	1.05
324	43	MA1123.2	TWIST1	MA1123.2	NNDCCAGATGTBN	TWIST1	1.17e-10	1.24e-13	7080	57.1	10900	52.9	1.08
325	14	MA0775.1	MEIS3	MA0775.1	DTGACAGS	MEIS3	1.17e-10	1.24e-13	4060	32.8	5940	28.9	1.13
326	64	MA1111.1	NR2F2	MA1111.1	NAAAGGTCANR	NR2F2	1.48e-10	1.56e-13	7840	63.2	12100	59.1	1.07
327	56	MA0689.1	TBX20	MA0689.1	WAGGTGTGAAR	TBX20	1.84e-10	1.94e-13	5770	46.5	8710	42.4	1.1
328	31	MA0484.2	HNF4G	MA0484.2	DNCAAAGTCCANN	HNF4G	2.17e-10	2.27e-13	8550	68.9	13300	65	1.06
329	10	MA0913.2	HOXD9	MA0913.2	GYMATAAAAH	HOXD9	2.17e-10	2.27e-13	2610	21	3650	17.8	1.18
330	45	MA1950.1	FLI1::FOXI1	MA1950.1	RTAAACAGGAARYN	FLI1::FOXI1	2.18e-10	2.27e-13	8130	65.5	12600	61.6	1.06
331	30	MA0488.1	JUN	MA0488.1	DDRATGATGTCAT	JUN	2.26e-10	2.35e-13	2010	16.2	2720	13.3	1.22
332	48	MA0743.2	SCRT1	MA0743.2	NDWKCAACAGGTGKNN	SCRT1	3.07e-10	3.18e-13	5380	43.4	8080	39.4	1.1
333	22	MA1547.2	PITX2	MA1547.2	YTAATCCY	PITX2	3.69e-10	3.81e-13	3100	25	4430	21.6	1.16
334	46	MA1148.1	PPARA::RXRA	MA1148.1	AWNTRGGTYAAAGGTCAN	PPARA::RXRA	3.79e-10	3.9e-13	6940	56	10700	51.9	1.08
335	65	MA0620.3	MITF	MA0620.3	NNNDRTCACGTGAYHNNN	MITF	6.07e-10	6.23e-13	2070	16.7	2830	13.8	1.21
336	66	MA0673.1	NKX2-8	MA0673.1	VCACTTSAV	NKX2-8	6.17e-10	6.32e-13	9770	78.8	15500	75.4	1.05
337	30	MA1131.1	FOSL2::JUN	MA1131.1	GRTGACGTMAT	FOSL2::JUN	7.3e-10	7.45e-13	4700	37.9	6990	34	1.11
338	2	MA0702.2	LMX1A	MA0702.2	TTAATTAM	LMX1A	2.95e-09	3e-12	1890	15.2	2580	12.5	1.21
339	67	MA1571.1	TGIF2LX	MA1571.1	TGACAGCTGTCA	TGIF2LX	3.37e-09	3.42e-12	4750	38.3	7100	34.6	1.11
340	2	MA0683.1	POU4F2	MA0683.1	RTGCATAATTAATGAG	POU4F2	4.91e-09	4.97e-12	1460	11.8	1930	9.4	1.25
341	1	MA0591.1	Bach1::Mafk	MA0591.1	RSSATGACTCAGCAB	Bach1::Mafk	5.75e-09	5.8e-12	2560	20.6	3610	17.6	1.17
342	56	MA0804.1	TBX19	MA0804.1	DTTMRCACMTAGGTGTGAAW	TBX19	6.38e-09	6.42e-12	2910	23.5	4160	20.3	1.16
343	18	MA0869.2	Sox11	MA0869.2	NRGAACAAAGVV	Sox11	7.45e-09	7.47e-12	10500	84.4	16700	81.6	1.04
344	30	MA0693.3	Vdr	MA0693.3	NNGAGTTCANN	Vdr	9.42e-09	9.42e-12	10700	86.4	17200	83.6	1.03
345	34	MA0519.1	Stat5a::Stat5b	MA0519.1	DTTTCCMAGAA	Stat5a::Stat5b	9.9e-09	9.87e-12	5840	47.1	8890	43.3	1.09
346	7	MA0029.1	Mecom	MA0029.1	AAGAYAAGATAANA	Mecom	1.08e-08	1.08e-11	1030	8.28	1300	6.31	1.31
347	45	MA1579.1	ZBTB26	MA1579.1	NNCTCCAGAAANNNN	ZBTB26	1.71e-08	1.69e-11	9810	79.1	15600	75.9	1.04
348	30	MA0684.2	RUNX3	MA0684.2	NHAACCTCAANN	RUNX3	2.31e-08	2.29e-11	10100	81.1	16000	78	1.04
349	21	MA0468.1	DUX4	MA0468.1	TAAYYYAATCA	DUX4	2.56e-08	2.52e-11	1280	10.3	1670	8.14	1.26
350	68	MA0092.1	Hand1::Tcf3	MA0092.1	BRTCTGGMWT	Hand1::Tcf3	3.24e-08	3.19e-11	5170	41.7	7820	38.1	1.1
351	42	MA1118.1	SIX1	MA1118.1	GWAACCTGAKM	SIX1	3.37e-08	3.3e-11	3190	25.7	4630	22.6	1.14
352	10	MA0063.2	NKX2-5	MA0063.2	NNCACTCAANN	NKX2-5	4.86e-08	4.75e-11	2680	21.6	3830	18.7	1.16
353	64	MA1541.1	NR6A1	MA1541.1	NYCAAGKTCAAGKTCAN	NR6A1	5.92e-08	5.77e-11	7580	61.1	11800	57.5	1.06
354	64	MA0160.2	NR4A2	MA0160.2	BWAAAGGTCA	NR4A2	6.52e-08	6.34e-11	8930	72	14100	68.6	1.05
355	43	MA1642.1	NEUROG2	MA1642.1	NNVACAGATGGNN	NEUROG2	6.92e-08	6.7e-11	9640	77.7	15300	74.6	1.04
356	69	MA0080.6	Spi1	MA0080.6	RRAAAGAGGAAGTGGDD	Spi1	8.77e-08	8.48e-11	7450	60	11600	56.5	1.06
357	30	MA1136.1	FOSB::JUNB	MA1136.1	RTGACGTCAT	FOSB::JUNB	9.74e-08	9.39e-11	4810	38.8	7240	35.3	1.1
358	84	MA1714.1	ZNF675	MA1714.1	RGGVHYMGGAGGMCAAAATGD	ZNF675	1.22e-07	1.17e-10	6520	52.5	10000	48.9	1.07
359	30	MA1133.1	JUN::JUNB	MA1133.1	KRTGACGTCATN	JUN::JUNB	1.22e-07	1.17e-10	9660	77.9	15400	74.8	1.04
360	10	MA1994.1	Nkx2-1	MA1994.1	NVCACTTGARHNN	Nkx2-1	1.43e-07	1.36e-10	2230	18	3140	15.3	1.17
361	70	MA0596.1	SREBF2	MA0596.1	RTGGGGTGAY	SREBF2	1.44e-07	1.37e-10	1120	9	1450	7.07	1.27
362	71	MA0691.1	TFAP4	MA0691.1	AWCAGCTGWT	TFAP4	2.23e-07	2.12e-10	1120	9.02	1460	7.1	1.27
363	23	MA0908.1	HOXD11	MA0908.1	RTCGTAAAAH	HOXD11	2.36e-07	2.23e-10	2380	19.2	3380	16.5	1.16
364	72	MA0671.1	NFIX	MA0671.1	NNTGCCAAN	NFIX	2.53e-07	2.39e-10	7880	63.5	12300	60.1	1.06
365	73	MA1984.1	ZNF667	MA1984.1	TTAAGAGCTCAV	ZNF667	2.61e-07	2.46e-10	8030	64.8	12600	61.4	1.06
366	57	MA0672.1	NKX2-3	MA0672.1	VCCACTTRAV	NKX2-3	2.96e-07	2.79e-10	10500	84.3	16800	81.6	1.03
367	67	MA0667.1	MYF6	MA0667.1	AACARCTGTT	MYF6	3.13e-07	2.94e-10	3760	30.3	5570	27.1	1.12
368	43	MA1467.2	Atoh1	MA1467.2	RVCAGATGGYN	Atoh1	4.1e-07	3.83e-10	9450	76.2	15000	73.1	1.04
369	74	TGTGTGKGTRTGTGT	MEME-4	TGTGTGKGTRTGTGT	TGTGTGKGTRTGTGT	TGTGTGKGTRTGTGT	4.91e-07	4.58e-10	2770	22.4	4010	19.5	1.14
370	43	MA1108.2	MXI1	MA1108.2	NNCACATGBN	MXI1	7.01e-07	6.52e-10	6460	52	9980	48.6	1.07
371	33	MA0038.2	GFI1	MA0038.2	BMAATCACDGCA	GFI1	7.24e-07	6.71e-10	2030	16.4	2860	13.9	1.18
372	24	MA0040.1	Foxq1	MA0040.1	HATTGTTTATW	Foxq1	7.25e-07	6.71e-10	1610	13	2200	10.7	1.21
373	15	MA0773.1	MEF2D	MA0773.1	DCTAWAAATAGM	MEF2D	8.75e-07	8.07e-10	856	6.9	1080	5.28	1.31
374	30	MA0492.1	JUND	MA0492.1	DDDRATGABGTCATN	JUND	9.61e-07	8.84e-10	1630	13.2	2250	10.9	1.2
375	13	MA0838.1	CEBPG	MA0838.1	ATTRCGCAAY	CEBPG	1e-06	9.18e-10	3970	32	5920	28.9	1.11
376	34	MA0463.2	BCL6	MA0463.2	NYGCTTTCKAGGAAYN	BCL6	1.08e-06	9.87e-10	6540	52.7	10100	49.3	1.07
377	75	MA0479.1	FOXH1	MA0479.1	BNSAATCCACA	FOXH1	1.45e-06	1.32e-09	1650	13.3	2280	11.1	1.2
378	66	MA2003.1	NKX2-4	MA2003.1	CCACTTSAVV	NKX2-4	1.72e-06	1.57e-09	11000	88.4	17700	86.2	1.03
379	1	MA1520.1	MAF	MA1520.1	NTGCTGASTCAGCAH	MAF	1.83e-06	1.66e-09	4810	38.8	7300	35.6	1.09
380	11	MA0842.2	NRL	MA0842.2	AAWWNTGCTGACG	NRL	2.71e-06	2.45e-09	1000	8.06	1300	6.36	1.27
381	34	MA1116.1	RBPJ	MA1116.1	BVTGGGAANN	RBPJ	2.82e-06	2.55e-09	10800	87.4	17500	85.1	1.03
382	49	MA1707.1	DMRTA1	MA1707.1	AWTTGWTACAWT	DMRTA1	3.59e-06	3.24e-09	2570	20.7	3730	18.2	1.14
383	45	MA1508.1	IKZF1	MA1508.1	VVAACAGGAARN	IKZF1	4.56e-06	4.1e-09	7660	61.7	12000	58.6	1.05
384	69	MA1952.1	FOXJ2::ELF1	MA1952.1	RTAAACMGGAAGTR	FOXJ2::ELF1	5.23e-06	4.68e-09	6830	55	10600	51.8	1.06
385	62	MA1724.1	Rfx6	MA1724.1	HNCCTAGCAACHV	Rfx6	6.19e-06	5.53e-09	8440	68	13300	65	1.05
386	76	MA1592.1	ZNF274	MA1592.1	NRTRTGAGTTCTCGYN	ZNF274	6.45e-06	5.74e-09	2790	22.5	4070	19.8	1.13
387	77	MA1937.1	ERF::HOXB13	MA1937.1	VSCGGAARYNRTWAAN	ERF::HOXB13	6.46e-06	5.74e-09	10300	83.1	16600	80.6	1.03
388	67	MA0797.1	TGIF2	MA0797.1	TGACAGSTGTCA	TGIF2	6.93e-06	6.15e-09	873	7.04	1130	5.48	1.28
389	78	MA0502.2 (NFYB)	STREME-8	8-CSATTGGCCS	CSATTGGCCS	NFYB	7.64e-06	6.76e-09	325	2.62	348	1.7	1.55
390	56	MA0688.1	TBX2	MA0688.1	DAGGTGTGAAA	TBX2	7.76e-06	6.85e-09	5190	41.8	7940	38.7	1.08
391	30	MA0592.3	ESRRA	MA0592.3	NBTCAAGGTCAHN	ESRRA	8.7e-06	7.65e-09	4250	34.3	6420	31.3	1.1
392	34	MA0518.1	Stat4	MA0518.1	YTTCYRGGAARNVR	Stat4	1.26e-05	1.11e-08	2870	23.2	4220	20.6	1.13
393	64	MA0258.2	ESR2	MA0258.2	AGGTCASVNTGMCCY	ESR2	1.63e-05	1.43e-08	8310	67	13100	64	1.05
394	77	MA1949.1	FLI1::DRGX	MA1949.1	ACCGGAAGTAATTAT	FLI1::DRGX	1.84e-05	1.61e-08	7220	58.2	11300	55.1	1.06
395	30	MA0609.2	CREM	MA0609.2	NNDGTGACGTCACHNN	CREM	2.02e-05	1.76e-08	10300	83	16500	80.6	1.03
396	43	MA1570.1	TFAP4	MA1570.1	AHCATRTGDT	TFAP4	2.2e-05	1.91e-08	2630	21.2	3840	18.7	1.13
397	64	MA0141.3	ESRRB	MA0141.3	TCAAGGTCAWW	ESRRB	2.3e-05	2e-08	3240	26.1	4810	23.4	1.11
398	48	MA0647.1	GRHL1	MA0647.1	AAAACCGGTTTD	GRHL1	2.68e-05	2.31e-08	3910	31.5	5890	28.7	1.1
399	69	MA0136.3	Elf5	MA0136.3	RVAAGGAAGTNN	Elf5	2.71e-05	2.34e-08	8840	71.2	14000	68.4	1.04
400	40	MA0515.1	Sox6	MA0515.1	CCWTTGTYYY	Sox6	2.79e-05	2.4e-08	2370	19.1	3430	16.7	1.14
401	15	MA0660.1	MEF2B	MA0660.1	RCTAWAAATAGC	MEF2B	3.18e-05	2.73e-08	685	5.52	864	4.21	1.31
402	28	MA2002.1	Zfp335	MA2002.1	VNTCAGGCANH	Zfp335	3.52e-05	3.01e-08	3540	28.6	5310	25.8	1.11
403	71	MA0698.1	ZBTB18	MA0698.1	NATCCAGATGTKB	ZBTB18	4.11e-05	3.51e-08	5580	45	8620	42	1.07
404	70	MA0595.1	SREBF1	MA0595.1	VTCACCCCAY	SREBF1	5.3e-05	4.51e-08	1480	12	2070	10.1	1.19
405	48	MA1968.1	TFCP2	MA1968.1	AAACCGGTTY	TFCP2	5.73e-05	4.87e-08	8950	72.2	14300	69.4	1.04
406	69	MA0687.1	SPIC	MA0687.1	HAAAAGVGGAAGTA	SPIC	6.82e-05	5.78e-08	8700	70.2	13800	67.4	1.04
407	69	MA0761.2	ETV1	MA0761.2	NNACAGGAAGTGNN	ETV1	7.67e-05	6.49e-08	7590	61.2	12000	58.3	1.05
408	13	MA0639.1	DBP	MA0639.1	NRTTACGTAAYV	DBP	8.35e-05	7.04e-08	2720	21.9	4000	19.5	1.12
409	69	MA0598.3	EHF	MA0598.3	NNCACTTCCTGTTNN	EHF	9.72e-05	8.18e-08	7770	62.6	12300	59.7	1.05
410	69	MA0081.2	SPIB	MA0081.2	TYTCACTTCCTCTTTY	SPIB	0.000107	8.99e-08	3590	29	5400	26.3	1.1
411	56	MA1565.1	TBX18	MA1565.1	DRAGGTGTGAAR	TBX18	0.000159	1.33e-07	5560	44.8	8620	42	1.07
412	11	MA0117.2	Mafb	MA0117.2	AWWNTGCTGACD	Mafb	0.000228	1.91e-07	480	3.87	584	2.84	1.36
413	65	MA1995.1	Npas4	MA1995.1	NNTCGTGACHN	Npas4	0.000278	2.32e-07	10100	81.1	16200	78.8	1.03
414	56	MA1567.2	Tbx6	MA1567.2	NRGGTGTGAANN	Tbx6	0.000393	3.27e-07	4690	37.8	7210	35.1	1.08
415	56	MA0690.2	TBX21	MA0690.2	TTTCACACCTT	TBX21	0.000396	3.28e-07	6270	50.6	9810	47.8	1.06
416	43	MA1109.1	NEUROD1	MA1109.1	NRACAGATGGYNN	NEUROD1	0.000462	3.82e-07	10700	86.2	17300	84.3	1.02
417	2	MA1546.1	PAX3	MA1546.1	YSGTCACGSYWATTAN	PAX3	0.000576	4.75e-07	5410	43.6	8400	40.9	1.07
418	69	MA0640.2	ELF3	MA0640.2	NNCCACTTCCTGNT	ELF3	0.000834	6.86e-07	9390	75.7	15000	73.3	1.03
419	55	MA0002.2	Runx1	MA0002.2	BBYTGTGGTTT	Runx1	0.000889	7.3e-07	8220	66.3	13100	63.7	1.04
420	43	MA0669.1	NEUROG2	MA0669.1	RACATATGTC	NEUROG2	0.00114	9.37e-07	1550	12.5	2210	10.8	1.16
421	48	MA0744.2	SCRT2	MA0744.2	NNWGCAACAGGTGDNN	SCRT2	0.00144	1.17e-06	2160	17.4	3180	15.5	1.13
422	64	MA1540.2	NR5A1	MA1540.2	NNRAGTTCAAGGTCANN	NR5A1	0.00157	1.28e-06	2140	17.3	3150	15.3	1.13
423	43	MA0668.2	Neurod2	MA0668.2	NNGRACAGATGGYNN	Neurod2	0.00189	1.53e-06	9120	73.5	14600	71.2	1.03
424	79	MA0101.1	REL	MA0101.1	BGGRNWTTCC	REL	0.00233	1.89e-06	10900	87.8	17700	86	1.02
425	43	MA1638.1	HAND2	MA1638.1	NVCAGATGNN	HAND2	0.00249	2.02e-06	7020	56.6	11100	54	1.05
426	62	MA1649.1	ZBTB12	MA1649.1	NYCTRGAACHN	ZBTB12	0.00272	2.2e-06	5990	48.3	9390	45.7	1.06
427	45	MA1954.1	FOXO1::ELK1	MA1954.1	RWMAACAGGAAGTD	FOXO1::ELK1	0.00312	2.51e-06	3540	28.5	5390	26.2	1.09
428	7	MA0140.2	GATA1::TAL1	MA0140.2	MTTATCWSNNNNNHVCAG	GATA1::TAL1	0.00357	2.87e-06	578	4.66	749	3.65	1.28
429	30	MA1996.1	Nr1H2	MA1996.1	NNRAGGTCANN	Nr1H2	0.00373	2.99e-06	9290	74.9	14900	72.7	1.03
430	56	MA0803.1	TBX15	MA0803.1	AGGTGTGA	TBX15	0.00386	3.09e-06	4670	37.6	7230	35.2	1.07
431	29	MA0780.1	PAX3	MA0780.1	TAATYRATTA	PAX3	0.00388	3.1e-06	893	7.2	1220	5.95	1.21
432	1	MA1521.1	MAFA	MA1521.1	NTGCTGASTCAGCAN	MAFA	0.0042	3.34e-06	5010	40.4	7780	37.9	1.06
433	2	MA0703.2	LMX1B	MA0703.2	AWTTTAATTAA	LMX1B	0.00598	4.75e-06	595	4.8	779	3.79	1.26
434	43	MA0607.2	BHLHA15	MA0607.2	ACCATATGGT	BHLHA15	0.00614	4.87e-06	1500	12.1	2170	10.6	1.15
435	69	MA0062.3	GABPA	MA0062.3	NNCACTTCCTGTNN	GABPA	0.00732	5.79e-06	6680	53.8	10500	51.4	1.05
436	77	MA1940.1	ETV2::DRGX	MA1940.1	RVCGGAAGYAATTA	ETV2::DRGX	0.00896	7.07e-06	6360	51.3	10000	48.8	1.05
437	80	MA0106.3	TP53	MA0106.3	RACATGYCCGGRCATGTY	TP53	0.0098	7.72e-06	967	7.8	1340	6.55	1.19
438	77	MA1944.1	ETV5::DRGX	MA1944.1	RSMGGAAGYAATTA	ETV5::DRGX	0.012	9.44e-06	6880	55.5	10900	53.1	1.04
439	64	MA1534.1	NR1I3	MA1534.1	RTGAACTTT	NR1I3	0.0135	1.06e-05	3140	25.3	4780	23.3	1.09
440	72	MA0161.2	NFIC	MA0161.2	NNCTTGGCANN	NFIC	0.0141	1.1e-05	1150	9.27	1630	7.94	1.17
441	81	MA1717.1	ZNF784	MA1717.1	GTACYTACCGH	ZNF784	0.0182	1.42e-05	9160	73.9	14700	71.8	1.03
442	67	MA1572.1	TGIF2LY	MA1572.1	TGACAGCTGTCA	TGIF2LY	0.0199	1.55e-05	1030	8.3	1450	7.07	1.18
443	82	MA1117.1	RELB	MA1117.1	RDATTCCCCNN	RELB	0.0208	1.62e-05	7970	64.2	12700	62	1.04
444	69	MA0474.3	Erg	MA0474.3	NNACAGGAAGTGVN	Erg	0.0211	1.64e-05	7600	61.2	12100	59	1.04
445	44	MA1473.1	CDX4	MA1473.1	GGYMATAAAAC	CDX4	0.0214	1.66e-05	908	7.32	1260	6.16	1.19
446	23	MA0651.2	HOXC11	MA0651.2	AGGTCGTAAAAH	HOXC11	0.0219	1.69e-05	1760	14.2	2600	12.6	1.12
447	80	MA0861.1	TP73	MA0861.1	DRCATGTCNNRACAYGYM	TP73	0.0221	1.7e-05	1440	11.6	2090	10.2	1.14
448	64	MA0643.1	Esrrg	MA0643.1	TCAAGGTCAH	Esrrg	0.0304	2.33e-05	7760	62.6	12400	60.4	1.04
449	64	MA0505.2	Nr5A2	MA0505.2	NTGACCTTGAMCT	Nr5A2	0.0307	2.35e-05	2080	16.8	3100	15.1	1.11
14	83	MA1728.1 (ZNF549)	STREME-12	12-AGGCAGGAT	12-AGGCAGGAT	ZNF549	0.0478	0.00342	1570	12.6	2380	11.6	1.09
15	84	MA1596.1 (ZNF460)	MEME-3	GGGAGGMKGRGGMGG	GGGAGGMKGRGGMGG	ZNF460	0.0913	0.00609	110	0.89	130	0.63	1.4
16	85	11-CAAGCCCATGGA	STREME-11	11-CAAGCCCATGGA	11-CAAGCCCATGGA	CAAGCCCATGGA	0.144	0.00898	1510	12.2	2320	11.3	1.08

ER_rat <- 1.25

DOX_242kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DOX_242kb_combo response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DOX_242kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y, TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*4), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( "DOX_24 2kb response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DOX_DAR 24 20kb data

DOX_24_20kb_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_20kb_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DOX_24_20kb_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_20kb_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DOX_24_20kb_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_20kb_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DOX_24_20kb_sea_all <- rbind(DOX_24_20kb_sea_disc, DOX_24_20kb_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DOX_24_20kb_combo <- DOX_24_20kb_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DOX_24_20kb_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

DOX_24_20kb_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in DOX24 20kb ") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in DOX24 20kb
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA1134.1 (FOS::JUNB)	STREME-1	1-RATGASTCATY	RATGASTCATY	FOS::JUNB	0	0	6210	17.4	4170	8.15	2.14
2	1	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	0	0	5840	16.4	3860	7.55	2.17
3	1	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	0	0	6400	18	4450	8.7	2.07
4	1	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	0	0	5770	16.2	3800	7.44	2.18
5	1	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	0	0	5270	14.8	3300	6.45	2.29
6	1	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	0	0	4970	14	3040	5.95	2.35
7	1	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	0	0	4470	12.6	2560	5	2.51
8	1	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	0	0	5540	15.6	3620	7.08	2.2
9	1	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	0	0	5050	14.2	3140	6.14	2.31
10	1	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	0	0	6780	19.1	4960	9.68	1.97
11	1	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	0	0	5990	16.8	4140	8.1	2.08
12	1	MA0476.1 (FOS)	MEME-1	ATGASTCA	ATGASTCA	FOS	0	0	6870	19.3	5100	9.97	1.94
13	1	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	0	0	6610	18.6	4820	9.42	1.97
14	1	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	5.48906932529625e-321	5.48906932529625e-321	6930	19.5	5210	10.2	1.91
15	1	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	2.22999987709968e-318	6.65012359302318e-320	5500	15.5	3710	7.24	2.14
16	1	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	5.96999999997705e-313	1.680000000216e-314	6560	18.4	4860	9.5	1.94
17	1	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	2.35e-309	6.19000000000023e-311	5230	14.7	3480	6.8	2.16
18	1	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	2.78e-308	6.92e-310	6060	17	4350	8.49	2
19	1	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	3.45e-304	8.14999999999999e-306	5700	16	3990	7.79	2.05
20	1	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	3.72e-298	8.34e-300	7320	20.6	5800	11.3	1.82
21	1	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	1.49e-293	3.19e-295	5790	16.3	4150	8.1	2.01
22	1	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	1.8e-292	3.67e-294	5750	16.2	4110	8.03	2.01
23	1	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	1.2e-289	2.35e-291	6360	17.9	4790	9.36	1.91
24	1	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	3.97e-286	7.43e-288	4590	12.9	2950	5.77	2.24
25	1	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	5.85e-285	1.05e-286	4920	13.8	3290	6.43	2.15
26	1	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	1.5e-283	2.59e-285	6730	18.9	5240	10.2	1.85
27	1	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	1.12e-281	1.86e-283	5990	16.8	4440	8.68	1.94
28	1	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	9.1e-230	1.46e-231	4010	11.3	2670	5.21	2.16
29	1	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	5.7e-154	8.81e-156	8820	24.8	8870	17.3	1.43
30	1	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	4.46e-151	6.67e-153	4670	13.1	3910	7.64	1.72
31	1	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	1.59e-112	2.3e-114	13700	38.5	15900	31	1.24
32	2	MA0018.4 (CREB1)	STREME-2	2-ATGACW	ATGACW	CREB1	3.05e-102	4.27e-104	26900	75.7	35300	69	1.1
33	1	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	5.9e-78	8.02e-80	13800	38.8	16600	32.5	1.19
34	3	MA0718.1	RAX	MA0718.1	RYYAATTARH	RAX	5.22e-73	6.89e-75	29400	82.7	39700	77.6	1.07
35	4	3-RATAAG	STREME-3	3-RATAAG	RATAAG	RATAAG	1.84e-72	2.36e-74	26800	75.4	35700	69.7	1.08
36	5	MA0808.1 (TEAD3)	STREME-4	4-ATWCMA	ATWCMA	TEAD3	4.13e-71	5.15e-73	29600	83.3	40100	78.4	1.06
37	3	MA0720.1	Shox2	MA0720.1	YYAATTAR	Shox2	3.06e-70	3.72e-72	29100	81.7	39200	76.6	1.07
38	1	MA0150.2	Nfe2l2	MA0150.2	CASNATGACTCAGCA	Nfe2l2	6.91e-70	8.16e-72	20700	58.1	26600	52	1.12
39	3	MA0725.1	VSX1	MA0725.1	YTAATTAN	VSX1	4.64e-69	5.33e-71	31100	87.4	42500	83.1	1.05
40	3	MA0027.2	EN1	MA0027.2	SYAATTAV	EN1	9.31e-69	1.04e-70	29800	83.8	40400	79	1.06
41	1	MA1639.1	MEIS1	MA1639.1	NHCATMAATCAHN	MEIS1	1.61e-66	1.76e-68	20100	56.5	25800	50.4	1.12
42	3	MA0674.1	NKX6-1	MA0674.1	NTMATTAA	NKX6-1	5.16e-66	5.52e-68	31500	88.5	43200	84.3	1.05
43	3	MA0710.1	NOTO	MA0710.1	NYTAATTAVN	NOTO	3.38e-65	3.53e-67	27900	78.5	37500	73.4	1.07
44	3	MA0726.1	VSX2	MA0726.1	CTAATTAN	VSX2	1.79e-64	1.82e-66	29500	82.9	40000	78.1	1.06
45	1	MA1113.2	PBX2	MA1113.2	NHCATAAATCAHN	PBX2	2.17e-64	2.16e-66	27800	78.1	37300	72.9	1.07
46	3	MA0704.1	Lhx4	MA0704.1	YTAATTAR	Lhx4	3.74e-64	3.65e-66	26500	74.6	35400	69.2	1.08
47	6	MA0035.4	GATA1	MA0035.4	NHCTAATCTDH	GATA1	4.93e-64	4.71e-66	30000	84.3	40800	79.7	1.06
48	3	MA0716.1	PRRX1	MA0716.1	YYAATTAR	PRRX1	5.33e-63	4.98e-65	26500	74.5	35400	69.2	1.08
49	3	MA0882.1	DLX6	MA0882.1	VYAATTAN	DLX6	1.89e-62	1.71e-64	28000	78.8	37700	73.7	1.07
50	7	MA0676.1	Nr2e1	MA0676.1	AAAAGTCAA	Nr2e1	1.91e-62	1.71e-64	23700	66.6	31200	60.9	1.09
51	3	MA0902.2	HOXB2	MA0902.2	SYAATTAS	HOXB2	2.9e-62	2.55e-64	21800	61.2	28300	55.4	1.1
52	3	MA0717.1	RAX2	MA0717.1	YYAATTAV	RAX2	3.04e-61	2.63e-63	29100	81.9	39500	77.2	1.06
53	3	MA1476.2	Dlx5	MA1476.2	NDGCAATTAGNN	Dlx5	5.82e-61	4.93e-63	30400	85.5	41500	81.1	1.05
54	1	MA1640.1	MEIS2	MA1640.1	NNATGATTTATGDNH	MEIS2	7.84e-61	6.51e-63	26800	75.4	36000	70.3	1.07
55	3	MA0630.1	SHOX	MA0630.1	HTAATTRR	SHOX	9.06e-61	7.39e-63	27200	76.6	36600	71.5	1.07
56	3	MA1963.1	SATB1	MA1963.1	WWDCTAATAAHWW	SATB1	1.79e-60	1.43e-62	24300	68.2	32100	62.7	1.09
57	3	MA0675.1	NKX6-2	MA0675.1	NYMATTAA	NKX6-2	6.14e-60	4.84e-62	29000	81.4	39200	76.7	1.06
58	3	MA0885.2	Dlx2	MA0885.2	NDGCAATTAGNN	Dlx2	5.07e-58	3.92e-60	29800	83.9	40700	79.5	1.06
59	3	MA0721.1	UNCX	MA0721.1	YYAATTAV	UNCX	2.47e-57	1.88e-59	27100	76	36400	71.1	1.07
60	3	MA0723.2	VAX2	MA0723.2	BYAATTAV	VAX2	2.52e-57	1.89e-59	26600	74.9	35700	69.8	1.07
61	3	MA0125.1	Nobox	MA0125.1	TAATTRSY	Nobox	2.77e-57	2.03e-59	29900	84.1	40800	79.7	1.05
62	3	MA0680.2	Pax7	MA0680.2	DWTAATCAATTAWNH	Pax7	4.43e-57	3.21e-59	23600	66.3	31200	60.9	1.09
63	8	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	6.42e-56	4.57e-58	28200	79.4	38200	74.7	1.06
64	3	MA0876.1	BSX	MA0876.1	SYVATTAV	BSX	2.83e-55	1.98e-57	29400	82.6	40000	78.2	1.06
65	9	MA1480.1	DPRX	MA1480.1	AGATAATCCN	DPRX	3.06e-55	2.11e-57	29200	82.1	39800	77.7	1.06
66	3	MA0628.1	POU6F1	MA0628.1	AYTAATTART	POU6F1	7.53e-55	5.12e-57	27700	77.9	37400	73.2	1.06
67	10	MA0602.1	Arid5a	MA0602.1	SYAATATTGVDANH	Arid5a	8.17e-55	5.47e-57	27900	78.5	37700	73.7	1.06
68	3	MA0886.1	EMX2	MA0886.1	VBTAATTARB	EMX2	8.59e-55	5.67e-57	19900	55.9	25800	50.4	1.11
69	3	MA0648.1	GSC	MA0648.1	VYTAATCCSY	GSC	1.08e-54	7.04e-57	29700	83.4	40500	79.1	1.05
70	3	MA0713.1	PHOX2A	MA0713.1	TAATYYAATTA	PHOX2A	2.23e-54	1.43e-56	23900	67.1	31600	61.8	1.09
71	11	MA0786.1	POU3F1	MA0786.1	WTATGCWAATKW	POU3F1	3.33e-54	2.11e-56	27300	76.7	36800	71.9	1.07
72	3	MA1495.1	HOXA1	MA1495.1	STAATTAS	HOXA1	4.87e-54	3.03e-56	16900	47.4	21500	41.9	1.13
73	11	MA0142.1	Pou5f1::Sox2	MA0142.1	CWTTGTYATGCAAAT	Pou5f1::Sox2	1.31e-53	8.04e-56	27300	76.7	36800	71.9	1.07
74	3	MA0880.1	Dlx3	MA0880.1	NYAATTAN	Dlx3	1.44e-53	8.72e-56	23500	66	31100	60.8	1.09
75	3	MA0890.1	GBX2	MA0890.1	RSYAATTARN	GBX2	2.17e-53	1.3e-55	25300	71	33800	66	1.08
76	12	MA0790.1	POU4F1	MA0790.1	ATGMATAATTAATG	POU4F1	6.01e-53	3.55e-55	24600	69.1	32700	64	1.08
77	12	MA0791.1	POU4F3	MA0791.1	RTGMATWATTAATGAR	POU4F3	6.95e-53	4.05e-55	21600	60.7	28300	55.3	1.1
78	3	MA0635.1	BARHL2	MA0635.1	VHTAAAYGRT	BARHL2	1.46e-52	8.38e-55	30000	84.2	41000	80.1	1.05
79	6	MA1104.2	GATA6	MA1104.2	HWWTCTTATCTNH	GATA6	2.78e-52	1.58e-54	21000	59	27500	53.7	1.1
80	3	MA0700.2	LHX2	MA0700.2	DDCCAATTADN	LHX2	1.26e-51	7.08e-54	26200	73.8	35300	68.9	1.07
81	8	MA0041.2	FOXD3	MA0041.2	WAWGHAAATAAACARY	FOXD3	1.6e-51	8.85e-54	27400	77	37000	72.3	1.06
82	3	MA0708.2	MSX2	MA0708.2	SCAATTAV	MSX2	3.42e-51	1.87e-53	28200	79.3	38300	74.8	1.06
83	3	MA0881.1	Dlx4	MA0881.1	VYAATTAN	Dlx4	4.9e-51	2.65e-53	22600	63.6	29900	58.4	1.09
84	3	MA0658.1	LHX6	MA0658.1	RCTAATTARY	LHX6	7.43e-51	3.97e-53	24400	68.6	32500	63.5	1.08
85	3	MA0899.1	HOXA10	MA0899.1	DGYMATAAAAH	HOXA10	1.76e-50	9.27e-53	29500	82.8	40200	78.6	1.05
86	3	MA0709.1	Msx3	MA0709.1	SCAATTAN	Msx3	1.99e-50	1.04e-52	21900	61.7	28900	56.5	1.09
87	11	MA0792.1	POU5F1B	MA0792.1	TATGCWAAT	POU5F1B	1.09e-49	5.6e-52	28100	78.8	38100	74.4	1.06
88	13	MA0901.2	HOXB13	MA0901.2	WDCCAATAAAAWWW	HOXB13	1.28e-49	6.55e-52	25100	70.4	33500	65.5	1.07
89	3	MA0650.3	Hoxa13	MA0650.3	NNCCAATAAAAN	Hoxa13	2.4e-49	1.21e-51	29000	81.4	39500	77.2	1.06
90	8	MA0032.2	FOXC1	MA0032.2	WAWGTAAAYAW	FOXC1	3.74e-49	1.87e-51	28400	80	38700	75.6	1.06
91	3	MA1502.1	HOXB8	MA1502.1	GYMATTAM	HOXB8	4.72e-49	2.33e-51	19300	54.3	25100	49.1	1.11
92	3	MA0068.2	PAX4	MA0068.2	CTAATTAG	PAX4	6.52e-49	3.18e-51	30800	86.5	42300	82.7	1.05
93	3	MA0891.1	GSC2	MA0891.1	NYTAATCCBH	GSC2	9.44e-49	4.56e-51	25500	71.8	34300	67	1.07
94	3	MA0122.3	Nkx3-2	MA0122.3	WWAAMCACTTAAN	Nkx3-2	1.69e-48	8.04e-51	28700	80.7	39100	76.4	1.06
95	3	MA0910.2	HOXD8	MA0910.2	GYMATTAM	HOXD8	2.07e-48	9.78e-51	19400	54.4	25200	49.2	1.11
96	3	MA0707.2	MNX1	MA0707.2	VYRATTAK	MNX1	4.94e-48	2.31e-50	18900	53.2	24600	48	1.11
97	3	MA1549.1	POU6F1	MA1549.1	RTAATGAGVN	POU6F1	1.22e-47	5.63e-50	19100	53.6	24800	48.4	1.11
98	11	MA0785.1	POU2F1	MA0785.1	AWTATGCWAATK	POU2F1	1.39e-47	6.36e-50	28100	79.1	38200	74.7	1.06
99	3	MA0661.1	MEOX1	MA0661.1	VSTAATTAHC	MEOX1	3.19e-47	1.45e-49	27300	76.8	37000	72.4	1.06
100	11	MA0788.1	POU3F3	MA0788.1	WWTATGCWAATTW	POU3F3	4.65e-47	2.09e-49	25800	72.5	34700	67.8	1.07
101	3	MA0903.1	HOXB3	MA0903.1	NNYMATTARN	HOXB3	6.64e-47	2.95e-49	27500	77.3	37300	72.9	1.06
102	3	MA1498.2	HOXA7	MA1498.2	SYMATTAV	HOXA7	1.39e-46	6.13e-49	26500	74.6	35800	70	1.07
103	6	MA0036.3	GATA2	MA0036.3	NBCTTATCTNH	GATA2	1.58e-46	6.89e-49	16600	46.8	21400	41.7	1.12
104	11	MA0627.2	POU2F3	MA0627.2	NWTATGCAAATNH	POU2F3	2.44e-46	1.05e-48	26200	73.6	35300	69	1.07
105	14	7-ABTGAG	STREME-7	7-ABTGAG	ABTGAG	ABTGAG	5.21e-46	2.23e-48	33600	94.5	47000	91.9	1.03
106	15	MA1623.1 (Stat2)	STREME-6	6-AACAGA	AACAGA	Stat2	5.66e-46	2.39e-48	32500	91.2	45100	88.1	1.04
107	6	MA0712.2	OTX2	MA0712.2	NDRGGATTARNN	OTX2	6.1e-46	2.56e-48	30800	86.6	42500	83	1.04
108	3	MA0654.1	ISX	MA0654.1	YYAATTAR	ISX	1.78e-45	7.38e-48	19700	55.3	25700	50.3	1.1
109	3	MA0662.1	MIXL1	MA0662.1	NBYAATTAVN	MIXL1	2.1e-45	8.65e-48	25100	70.6	33700	65.9	1.07
110	3	MA0681.2	PHOX2B	MA0681.2	WWTAATCAAATTAWWW	PHOX2B	3.8e-45	1.55e-47	20600	58	27100	53	1.09
111	3	MA0887.1	EVX1	MA0887.1	VVTAATTABS	EVX1	4.08e-45	1.65e-47	25900	72.7	34900	68.1	1.07
112	16	MA1978.1	ZNF354A	MA1978.1	HWAADWATAAATGRAYWAWTT	ZNF354A	5.1e-45	2.04e-47	26500	74.6	35900	70.1	1.06
113	17	MA0143.4	SOX2	MA0143.4	DNACAATGGNN	SOX2	6.51e-45	2.57e-47	30200	85	41600	81.2	1.05
114	18	MA0495.3	MAFF	MA0495.3	DWGTCAGCATTTTWHN	MAFF	6.54e-45	2.57e-47	29100	81.8	39800	77.7	1.05
115	9	MA0714.1	PITX3	MA0714.1	NYTAATCCC	PITX3	1.29e-44	5.03e-47	33100	93	46200	90.3	1.03
116	8	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	2.37e-44	9.15e-47	29800	83.8	40900	79.9	1.05
117	19	5-TCACAA	STREME-5	5-TCACAA	TCACAA	TCACAA	2.59e-44	9.93e-47	31400	88.2	43400	84.8	1.04
118	3	MA0706.1	MEOX2	MA0706.1	DSTAATTAWN	MEOX2	5.09e-44	1.94e-46	19000	53.4	24800	48.5	1.1
119	3	MA0158.2	HOXA5	MA0158.2	GYMATTAS	HOXA5	9.12e-44	3.44e-46	13200	37.1	16600	32.4	1.14
120	3	MA1519.1	LHX5	MA1519.1	STAATTAV	LHX5	1.17e-43	4.37e-46	14400	40.5	18300	35.7	1.13
121	20	MA0084.1	SRY	MA0084.1	NWWAACAAT	SRY	2.08e-43	7.7e-46	25600	71.8	34400	67.3	1.07
122	3	MA0793.1	POU6F2	MA0793.1	ASCTMATTAW	POU6F2	2.48e-43	9.1e-46	16600	46.6	21400	41.8	1.12
123	6	MA1970.1	TRPS1	MA1970.1	NHTCTTATCTNH	TRPS1	3.41e-43	1.24e-45	18800	52.8	24500	47.9	1.1
124	21	MA0052.4	MEF2A	MA0052.4	DDCTAAAAATAGMHH	MEF2A	5.04e-43	1.82e-45	22600	63.6	30100	58.8	1.08
125	3	MA1518.2	Lhx1	MA1518.2	NNNTGCTAATTAGCANNN	Lhx1	6.24e-43	2.24e-45	26700	75.2	36200	70.8	1.06
126	3	MA0699.1	LBX2	MA0699.1	NCYAATTARN	LBX2	6.84e-43	2.43e-45	26100	73.3	35200	68.8	1.06
127	3	MA0722.1	VAX1	MA0722.1	YTAATTAH	VAX1	2.34e-42	8.26e-45	19100	53.6	25000	48.8	1.1
128	9	MA0711.1	OTX1	MA0711.1	HTAATCCS	OTX1	2.99e-42	1.05e-44	27700	77.9	37700	73.7	1.06
129	11	MA0789.1	POU3F4	MA0789.1	TATGCWAAT	POU3F4	4.92e-42	1.71e-44	24000	67.4	32100	62.8	1.07
130	6	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	1.25e-41	4.32e-44	13900	39	17600	34.4	1.13
131	3	MA1481.1	DRGX	MA1481.1	YYAATTAN	DRGX	1.29e-41	4.4e-44	19600	55	25700	50.2	1.1
132	13	MA0465.2	CDX2	MA0465.2	NDGCAATAAAWN	CDX2	1.69e-41	5.74e-44	25700	72.2	34700	67.8	1.07
133	3	MA0904.2	HOXB5	MA0904.2	STAATTAS	HOXB5	1.94e-41	6.55e-44	12200	34.2	15200	29.7	1.15
134	3	MA0888.1	EVX2	MA0888.1	VVTAATTAVB	EVX2	2.18e-41	7.28e-44	30000	84.3	41300	80.6	1.05
135	3	MA0666.2	MSX1	MA0666.2	SCAATTAR	MSX1	4.13e-41	1.37e-43	23000	64.6	30700	59.9	1.08
136	3	MA1471.1	BARX2	MA1471.1	NWWAAYMATTAN	BARX2	4.18e-41	1.38e-43	26300	73.9	35600	69.6	1.06
137	3	MA0875.1	BARX1	MA0875.1	VCMATTAV	BARX1	5.41e-41	1.77e-43	27300	76.8	37200	72.7	1.06
138	3	MA0634.1	ALX3	MA0634.1	YYYAATTANV	ALX3	1.21e-40	3.95e-43	23200	65.3	31100	60.7	1.08
139	3	MA0892.1	GSX1	MA0892.1	NCYMATTAVN	GSX1	1.78e-40	5.75e-43	27300	76.7	37100	72.5	1.06
140	8	MA0148.4	FOXA1	MA0148.4	WWGTAAACATNN	FOXA1	3.71e-40	1.19e-42	30700	86.2	42400	82.8	1.04
141	8	MA1607.1	Foxl2	MA1607.1	DDWATGTAAACANN	Foxl2	4.63e-40	1.47e-42	30900	86.8	42700	83.4	1.04
142	17	MA1152.1	SOX15	MA1152.1	CYWTTGTTHW	SOX15	1.95e-39	6.17e-42	27300	76.8	37200	72.7	1.06
143	6	MA0037.4	Gata3	MA0037.4	NHTCTTATCTNH	Gata3	2.25e-38	7.06e-41	18700	52.5	24500	47.9	1.1
144	3	MA0879.2	DLX1	MA0879.2	VYAATTAN	DLX1	2.71e-38	8.45e-41	22900	64.5	30700	60	1.07
145	3	MA0705.1	Lhx8	MA0705.1	CTAATTAV	Lhx8	3.98e-38	1.23e-40	17400	49	22700	44.4	1.1
146	3	MA1505.1	HOXC8	MA1505.1	KTAATTAM	HOXC8	5.24e-38	1.61e-40	17600	49.5	23000	44.9	1.1
147	3	MA1530.1	NKX6-3	MA1530.1	VYCATTAWW	NKX6-3	9.39e-38	2.87e-40	21100	59.3	28000	54.7	1.08
148	17	MA0077.1	SOX9	MA0077.1	CYATTGTTY	SOX9	2.63e-37	7.97e-40	32600	91.7	45600	89	1.03
149	8	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	5.79e-37	1.74e-39	28800	80.9	39500	77.2	1.05
150	22	MA0769.2	TCF7	MA0769.2	NNCTTTGAWVT	TCF7	1.35e-36	4.04e-39	29500	83	40600	79.4	1.04
151	3	MA0701.2	LHX9	MA0701.2	CYAATTAR	LHX9	1.52e-36	4.53e-39	13300	37.4	16900	33.1	1.13
152	22	MA0523.1	TCF7L2	MA0523.1	DRASATCAAAGRVA	TCF7L2	6.39e-36	1.89e-38	20600	58	27400	53.6	1.08
153	3	MA0889.1	GBX1	MA0889.1	VCYAATTASY	GBX1	2.34e-35	6.85e-38	19100	53.8	25200	49.3	1.09
154	3	MA0612.2	EMX1	MA0612.2	BTAATTAS	EMX1	2.44e-35	7.1e-38	14400	40.4	18400	36	1.12
155	11	MA1115.1	POU5F1	MA1115.1	WHATGCAAATN	POU5F1	8.59e-35	2.47e-37	29600	83.3	40900	79.9	1.04
156	23	MA0809.2	TEAD4	MA0809.2	NNACATTCCARN	TEAD4	8.59e-35	2.47e-37	32100	90.2	44800	87.4	1.03
157	8	MA1103.2	FOXK2	MA1103.2	DDGTAAACANN	FOXK2	1.08e-34	3.08e-37	31100	87.6	43200	84.5	1.04
158	3	MA0894.1	HESX1	MA0894.1	GHTAATTRRH	HESX1	1.09e-34	3.1e-37	20000	56.2	26500	51.8	1.08
159	8	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	1.15e-34	3.26e-37	29100	81.9	40100	78.3	1.04
160	24	MA0108.2	TBP	MA0108.2	STATAAAWRSVVVBN	TBP	1.18e-34	3.31e-37	28900	81.3	39800	77.7	1.05
161	3	MA0644.2	ESX1	MA0644.2	YYAATTAN	ESX1	1.36e-34	3.8e-37	16100	45.3	20900	40.9	1.11
162	3	MA0075.3	PRRX2	MA0075.3	CTAATTAN	PRRX2	1.7e-34	4.7e-37	14800	41.6	19100	37.3	1.12
163	17	MA0868.2	SOX8	MA0868.2	MGAACAATRG	SOX8	2.67e-34	7.34e-37	30100	84.6	41600	81.3	1.04
164	9	MA0682.2	PITX1	MA0682.2	YTAATCCH	PITX1	2.76e-34	7.55e-37	18900	53.1	24900	48.7	1.09
165	17	MA1120.1	SOX13	MA1120.1	DVACAATGGNN	SOX13	3.81e-34	1.03e-36	29600	83.3	40900	79.9	1.04
166	8	MA0042.2	FOXI1	MA0042.2	GTAAACA	FOXI1	3.83e-34	1.04e-36	26200	73.6	35600	69.6	1.06
167	3	MA0642.2	EN2	MA0642.2	VSYAATTA	EN2	5.03e-34	1.35e-36	25400	71.3	34400	67.3	1.06
168	17	MA1563.2	SOX18	MA1563.2	AACAATDV	SOX18	6.49e-34	1.73e-36	26700	75.1	36400	71.2	1.05
169	8	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	6.74e-34	1.79e-36	32000	89.9	44600	87.1	1.03
170	3	MA1497.1	HOXA6	MA1497.1	BGYMATTANN	HOXA6	1.41e-33	3.73e-36	27100	76.1	37000	72.3	1.05
171	8	MA0047.3	FOXA2	MA0047.3	RWGTAAACANN	FOXA2	3.34e-33	8.77e-36	28800	80.8	39600	77.3	1.05
172	3	MA0912.2	HOXD3	MA0912.2	CTAATTAC	HOXD3	3.92e-33	1.02e-35	10400	29.1	12900	25.3	1.15
173	12	MA0046.2	HNF1A	MA0046.2	DRTTAATNATTAACN	HNF1A	1.61e-32	4.17e-35	15600	44	20300	39.7	1.11
174	8	MA0481.3	FOXP1	MA0481.3	NDGTAAACANH	FOXP1	1.63e-32	4.21e-35	28900	81.2	39800	77.7	1.04
175	3	MA0914.1	ISL2	MA0914.1	GCAMTTAR	ISL2	2.14e-32	5.49e-35	29000	81.4	39900	78	1.04
176	12	MA0153.2	HNF1B	MA0153.2	GTTAATNATTAAY	HNF1B	3.14e-32	8.01e-35	14800	41.6	19200	37.5	1.11
177	25	MA0679.2	ONECUT1	MA0679.2	WAAAAATCAATAAWWN	ONECUT1	6.31e-32	1.6e-34	18800	52.8	24900	48.6	1.09
178	8	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	1.05e-31	2.64e-34	29900	84	41300	80.8	1.04
179	3	MA0893.2	GSX2	MA0893.2	SYMATTAR	GSX2	1.53e-31	3.84e-34	29200	82.1	40300	78.8	1.04
180	3	MA0900.2	HOXA2	MA0900.2	STAATTAS	HOXA2	2.32e-31	5.79e-34	10600	29.9	13400	26.1	1.14
181	3	MA0896.1	Hmx1	MA0896.1	VSVAGCAATTAAWGVDB	Hmx1	3.92e-31	9.71e-34	18900	53.2	25100	49	1.09
182	25	MA0755.1	CUX2	MA0755.1	TRATCGATAW	CUX2	4.15e-31	1.02e-33	22000	62	29600	57.9	1.07
183	1	MA0591.1	Bach1::Mafk	MA0591.1	RSSATGACTCAGCAB	Bach1::Mafk	6.63e-31	1.63e-33	1310	3.69	1170	2.29	1.61
184	18	MA0117.2	Mafb	MA0117.2	AWWNTGCTGACD	Mafb	7.55e-31	1.84e-33	28100	79	38600	75.4	1.05
185	3	MA0124.2	Nkx3-1	MA0124.2	RCCACTTAA	Nkx3-1	1.73e-30	4.2e-33	29800	83.8	41300	80.7	1.04
186	26	MA0018.4	CREB1	MA0018.4	NNRTGATGTCAYN	CREB1	1.95e-30	4.7e-33	26000	73.2	35500	69.4	1.05
187	6	MA0482.2	GATA4	MA0482.2	NNCCTTATCTNH	GATA4	2.63e-30	6.32e-33	13400	37.7	17300	33.8	1.12
188	17	MA0514.2	Sox3	MA0514.2	DNACAATGGNN	Sox3	9.88e-30	2.36e-32	32600	91.8	45700	89.4	1.03
189	27	MA0836.2	CEBPD	MA0836.2	NRTTGCACAAYHN	CEBPD	2.47e-29	5.86e-32	28000	78.7	38500	75.3	1.05
190	28	MA0905.1	HOXC10	MA0905.1	GTCRTAAAAH	HOXC10	4.84e-29	1.14e-31	22300	62.6	30000	58.6	1.07
191	3	MA0898.1	Hmx3	MA0898.1	ASAAGCAATTAAWRRAT	Hmx3	9.72e-29	2.28e-31	18200	51.2	24100	47.2	1.09
192	26	MA1143.1	FOSL1::JUND	MA1143.1	RTGACGTMAY	FOSL1::JUND	2.67e-28	6.23e-31	23600	66.3	32000	62.4	1.06
193	3	MA1463.1	ARGFX	MA1463.1	DCTAATTARM	ARGFX	5.75e-28	1.34e-30	14500	40.7	18800	36.8	1.11
194	29	MA0502.2 (NFYB)	STREME-9	9-CCAATG	CCAATG	NFYB	9.09e-28	2.1e-30	34300	96.3	48500	94.7	1.02
195	3	MA0895.1	HMBOX1	MA0895.1	MYTAGTTAMS	HMBOX1	1.54e-27	3.55e-30	24700	69.5	33700	65.8	1.06
196	30	MA1489.1	FOXN3	MA1489.1	GTAAACAA	FOXN3	1.81e-27	4.15e-30	24200	68	32900	64.3	1.06
197	8	MA0850.1	FOXP3	MA0850.1	RTAAACA	FOXP3	5.82e-27	1.32e-29	29300	82.4	40600	79.3	1.04
198	17	MA1603.1	Dmrt1	MA1603.1	GHTACAAAGTADC	Dmrt1	5.87e-27	1.33e-29	26000	73	35500	69.4	1.05
199	3	MA1500.1	HOXB6	MA1500.1	BTAATKRC	HOXB6	1.16e-26	2.62e-29	22200	62.3	30000	58.6	1.06
200	31	MA1623.1	Stat2	MA1623.1	RGAAACAGAAASH	Stat2	1.94e-26	4.36e-29	31300	87.9	43700	85.3	1.03
201	17	MA0078.2	Sox17	MA0078.2	NNAGAACAATGGNN	Sox17	2.03e-26	4.52e-29	27300	76.7	37500	73.3	1.05
202	32	MA1657.1	ZNF652	MA1657.1	BAAAGRGTTAAN	ZNF652	2.06e-26	4.57e-29	21500	60.5	29000	56.7	1.07
203	22	MA0768.2	Lef1	MA0768.2	NNBCCTTTGATSTN	Lef1	6.1e-26	1.35e-28	30300	85.1	42100	82.3	1.03
204	3	MA1608.1	Isl1	MA1608.1	NNCCATTAGNN	Isl1	6.58e-26	1.45e-28	22700	63.8	30700	60	1.06
205	33	MA1562.1	SOX14	MA1562.1	CCGAACAATG	SOX14	1.6e-25	3.51e-28	27500	77.4	37900	74.1	1.04
206	31	MA0050.3	Irf1	MA0050.3	ANTGAAACTGAAASH	Irf1	2.95e-25	6.42e-28	30500	85.7	42400	82.9	1.03
207	3	MA0853.1	Alx4	MA0853.1	CGCRYTAATTARYHNNY	Alx4	5.29e-25	1.15e-27	15200	42.7	19900	39	1.09
208	8	MA0852.2	FOXK1	MA0852.2	NRDGTAAACAAGNN	FOXK1	1.02e-24	2.21e-27	32300	90.9	45300	88.6	1.03
209	34	MA0611.2	Dux	MA0611.2	NTGATTBAATCAVWNN	Dux	1.09e-24	2.34e-27	11300	31.8	14500	28.4	1.12
210	3	MA0467.2	Crx	MA0467.2	NDGGATTANN	Crx	2e-24	4.27e-27	22200	62.3	30000	58.7	1.06
211	35	MA0774.1	MEIS2	MA0774.1	TTGACAGS	MEIS2	2.98e-24	6.34e-27	33300	93.6	46900	91.6	1.02
212	36	MA1125.1 (ZNF384)	MEME-2	TTTTTTTTTTTTTTT	TTTTTTTTTTTTTTT	ZNF384	3.09e-24	6.54e-27	22900	64.4	31100	60.8	1.06
213	3	MA0724.1	VENTX	MA0724.1	AMCGATTAR	VENTX	3.46e-24	7.29e-27	14500	40.7	19000	37.1	1.1
214	13	MA0913.2	HOXD9	MA0913.2	GYMATAAAAH	HOXD9	3.91e-24	8.2e-27	19100	53.8	25600	50.1	1.07
215	3	MA1504.1	HOXC4	MA1504.1	VTMATTAN	HOXC4	5.32e-24	1.11e-26	21600	60.6	29100	57	1.06
216	37	MA0606.2	Nfat5	MA0606.2	NNATGGAAAAWN	Nfat5	6.69e-24	1.39e-26	29600	83.2	41100	80.4	1.04
217	3	MA0897.1	Hmx2	MA0897.1	ASAAGCAATTAAHVVRT	Hmx2	7.77e-24	1.61e-26	19200	54.1	25800	50.4	1.07
218	3	MA1496.1	HOXA4	MA1496.1	RTMATTAV	HOXA4	2.98e-23	6.13e-26	24300	68.2	33100	64.8	1.05
219	38	MA0151.1	Arid3a	MA0151.1	ATYAAA	Arid3a	3.59e-23	7.35e-26	15600	43.7	20600	40.2	1.09
220	9	MA0883.1	Dmbx1	MA0883.1	WDRWNMGGATTADKNNW	Dmbx1	4.12e-23	8.4e-26	17300	48.5	23000	44.9	1.08
221	3	MA0909.3	Hoxd13	MA0909.3	NNCAATAAAW	Hoxd13	4.21e-23	8.55e-26	17600	49.6	23500	45.9	1.08
222	26	MA1112.2	NR4A1	MA1112.2	NNAAAGGTCANN	NR4A1	6.52e-23	1.32e-25	29100	81.7	40300	78.8	1.04
223	28	MA0911.1	Hoxa11	MA0911.1	RGTCGTAAAANT	Hoxa11	9.02e-23	1.82e-25	24200	68.1	33100	64.7	1.05
224	3	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	1.06e-22	2.11e-25	28700	80.7	39800	77.8	1.04
225	39	MA0877.3	BARHL1	MA0877.3	AMCGTTTA	BARHL1	1.27e-22	2.54e-25	29100	81.9	40500	79.1	1.04
226	28	MA0908.1	HOXD11	MA0908.1	RTCGTAAAAH	HOXD11	2.19e-22	4.35e-25	14100	39.8	18600	36.3	1.1
227	3	MA0132.2	PDX1	MA0132.2	VYAATTAR	PDX1	5.78e-22	1.14e-24	14600	41.1	19300	37.6	1.09
228	11	MA0787.1	POU3F2	MA0787.1	WTATGCWAATKA	POU3F2	1.19e-21	2.35e-24	19000	53.3	25500	49.8	1.07
229	23	MA0808.1	TEAD3	MA0808.1	RCATTCCW	TEAD3	1.44e-21	2.82e-24	13600	38.1	17800	34.8	1.1
230	3	MA1501.1	HOXB7	MA1501.1	GGTAATTAVS	HOXB7	2.61e-21	5.09e-24	18500	51.9	24800	48.4	1.07
231	40	MA0063.2	NKX2-5	MA0063.2	NNCACTCAANN	NKX2-5	2.88e-21	5.59e-24	27300	76.6	37700	73.6	1.04
232	26	MA1636.1	CEBPG	MA1636.1	NDATGATGCAATMHH	CEBPG	2.91e-21	5.62e-24	17300	48.7	23100	45.2	1.08
233	41	MA0092.1	Hand1::Tcf3	MA0092.1	BRTCTGGMWT	Hand1::Tcf3	4.52e-21	8.7e-24	32600	91.7	45900	89.7	1.02
234	3	MA1499.1	HOXB4	MA1499.1	RTMATTAR	HOXB4	8.96e-21	1.72e-23	13700	38.5	18000	35.2	1.09
235	42	MA1479.1	DMRTC2	MA1479.1	AATTGMTACATT	DMRTC2	1.94e-20	3.7e-23	26800	75.3	37000	72.3	1.04
236	8	MA0157.3	Foxo3	MA0157.3	NDGTAAACARNN	Foxo3	3.49e-20	6.64e-23	33800	95	47800	93.4	1.02
237	9	MA0719.1	RHOXF1	MA0719.1	NTRATCCN	RHOXF1	4.59e-20	8.7e-23	22600	63.7	30900	60.4	1.05
238	13	MA0878.3	CDX1	MA0878.3	GGYMATAAAA	CDX1	5.95e-20	1.12e-22	13300	37.4	17500	34.2	1.09
239	3	MA1960.1	MGA::EVX1	MA1960.1	RGGTGWTAATKD	MGA::EVX1	8.66e-20	1.63e-22	19300	54.4	26100	51	1.07
240	23	MA0090.3	TEAD1	MA0090.3	NNACATTCCAGSN	TEAD1	1.24e-19	2.32e-22	24400	68.6	33500	65.4	1.05
241	43	MA1624.1	Stat5a	MA1624.1	NTTCCAAGAANH	Stat5a	1.61e-19	3e-22	29700	83.6	41500	81	1.03
242	3	MA0601.1	Arid3b	MA0601.1	ATATTAATWAN	Arid3b	2.57e-19	4.77e-22	14800	41.6	19600	38.3	1.08
243	44	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	2.82e-19	5.22e-22	16900	47.6	22700	44.3	1.07
244	18	MA0842.2	NRL	MA0842.2	AAWWNTGCTGACG	NRL	2.84e-19	5.22e-22	9290	26.1	11900	23.3	1.12
245	3	MA0715.1	PROP1	MA0715.1	TAATYWAATTA	PROP1	4.39e-19	8.04e-22	13400	37.6	17600	34.4	1.09
246	21	MA0497.1	MEF2C	MA0497.1	DDDCYAAAAATAGMW	MEF2C	7.19e-19	1.31e-21	13500	38	17800	34.8	1.09
247	35	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	1.28e-18	2.32e-21	12500	35.1	16400	32	1.1
248	43	MA1625.1	Stat5b	MA1625.1	NNNTTCCCAGAANNN	Stat5b	5.15e-18	9.31e-21	29800	83.8	41700	81.4	1.03
249	8	MA0480.2	Foxo1	MA0480.2	NDGTAAACANN	Foxo1	6.54e-18	1.18e-20	33800	94.9	47800	93.4	1.02
250	45	MA0483.1	Gfi1B	MA0483.1	AAATCWCWGCH	Gfi1B	7.59e-18	1.36e-20	13100	36.9	17300	33.8	1.09
251	26	MA1131.1	FOSL2::JUN	MA1131.1	GRTGACGTMAT	FOSL2::JUN	9.85e-18	1.76e-20	25200	70.9	34800	67.9	1.04
252	26	MA0025.2	NFIL3	MA0025.2	NRTTATGYAATNN	NFIL3	1.47e-17	2.63e-20	13800	38.8	18300	35.8	1.09
253	46	MA1588.1	ZNF136	MA1588.1	RWATTCTTGGTTGRC	ZNF136	1.76e-17	3.12e-20	16600	46.7	22300	43.5	1.07
254	3	MA0618.1	LBX1	MA0618.1	TTAATTAG	LBX1	2.73e-17	4.83e-20	16900	47.6	22700	44.4	1.07
255	37	MA0152.2	Nfatc2	MA0152.2	NNRNAATGGAAANWNH	Nfatc2	7.32e-17	1.29e-19	33100	92.9	46700	91.2	1.02
256	47	MA1975.1	ZNF214	MA1975.1	VWTCATCAABGTCCT	ZNF214	1.11e-16	1.95e-19	28400	80	39600	77.4	1.03
257	25	MA0754.2	CUX1	MA0754.2	TAATCGATAM	CUX1	1.19e-16	2.08e-19	17900	50.4	24200	47.3	1.07
258	9	MA1547.2	PITX2	MA1547.2	YTAATCCY	PITX2	1.32e-16	2.29e-19	12000	33.8	15800	30.9	1.09
259	8	MA0031.1	FOXD1	MA0031.1	GTAAACAW	FOXD1	1.49e-16	2.58e-19	15900	44.8	21300	41.7	1.07
260	8	MA0851.1	Foxj3	MA0851.1	NDAADGTAAACAAANNM	Foxj3	2.15e-16	3.71e-19	18200	51.2	24600	48.1	1.06
261	48	MA1118.1	SIX1	MA1118.1	GWAACCTGAKM	SIX1	2.27e-16	3.91e-19	29500	83	41300	80.6	1.03
262	31	MA1709.1	ZIM3	MA1709.1	RVMAACAGAAACCYM	ZIM3	6.37e-16	1.09e-18	23800	67	32800	64.1	1.05
263	26	MA1127.1	FOSB::JUN	MA1127.1	GATGACGTCAT	FOSB::JUN	9.29e-16	1.59e-18	27300	76.6	37900	74	1.04
264	17	MA0095.3	Yy1	MA0095.3	NNCAAAATGGCN	Yy1	1.55e-15	2.63e-18	33400	93.8	47200	92.2	1.02
265	49	MA1729.1	ZNF680	MA1729.1	GNCCAAGAAGAATDA	ZNF680	1.61e-15	2.72e-18	22500	63.4	30900	60.5	1.05
266	50	MA1974.1	ZNF211	MA1974.1	HWYATATACCAYRYW	ZNF211	1.62e-15	2.73e-18	15100	42.5	20200	39.6	1.07
267	40	MA1523.1	MSANTD3	MA1523.1	STVCACTCAC	MSANTD3	1.71e-15	2.87e-18	30300	85.1	42400	82.9	1.03
268	43	MA0144.2	STAT3	MA0144.2	YTTCYKGGAAD	STAT3	1.99e-15	3.34e-18	20000	56.1	27200	53.2	1.06
269	26	MA0833.2	ATF4	MA0833.2	DDATGATGCAATMN	ATF4	2.49e-15	4.15e-18	16400	46.2	22100	43.3	1.07
270	51	MA1150.1	RORB	MA1150.1	AWWTRGGTCAH	RORB	3.31e-15	5.5e-18	32400	91	45700	89.2	1.02
271	27	MA0102.4	CEBPA	MA0102.4	NDATTGCACAATHN	CEBPA	3.39e-15	5.61e-18	16800	47.2	22600	44.2	1.07
272	42	MA1707.1	DMRTA1	MA1707.1	AWTTGWTACAWT	DMRTA1	4.1e-15	6.77e-18	25500	71.7	35300	69	1.04
273	40	MA1645.1	NKX2-2	MA1645.1	NNNCCACTCAANNN	NKX2-2	5.53e-15	9.08e-18	25900	72.8	35900	70.1	1.04
274	52	MA1593.1	ZNF317	MA1593.1	WVACAGCAGAYW	ZNF317	7.38e-15	1.21e-17	33600	94.5	47600	93.1	1.02
275	53	MA1124.1	ZNF24	MA1124.1	CATTCATTCATTC	ZNF24	7.94e-15	1.3e-17	8450	23.7	10900	21.3	1.12
276	3	MA0874.1	Arx	MA0874.1	VTBCRYTAATTARTKSW	Arx	1.37e-14	2.23e-17	12200	34.2	16100	31.4	1.09
277	40	MA1994.1	Nkx2-1	MA1994.1	NVCACTTGARHNN	Nkx2-1	1.94e-14	3.14e-17	26000	73.1	36000	70.4	1.04
278	17	MA0442.2	SOX10	MA0442.2	NDAACAAAGVN	SOX10	2.08e-14	3.36e-17	26000	73	36000	70.4	1.04
279	23	MA1121.1	TEAD2	MA1121.1	NYACATTCCWNNS	TEAD2	5.71e-14	9.18e-17	24600	69.2	34000	66.5	1.04
280	35	MA0775.1	MEIS3	MA0775.1	DTGACAGS	MEIS3	6.18e-14	9.9e-17	6820	19.2	8690	17	1.13
281	22	MA1991.1	Hnf1A	MA1991.1	NBCCTTTGATSTBN	Hnf1A	8.18e-14	1.31e-16	17400	49	23600	46.2	1.06
282	54	MA0140.2	GATA1::TAL1	MA0140.2	MTTATCWSNNNNNHVCAG	GATA1::TAL1	1.27e-13	2.01e-16	6640	18.6	8450	16.5	1.13
283	26	MA1632.1	ATF2	MA1632.1	NNATGABGTCATN	ATF2	1.52e-13	2.41e-16	15300	42.9	20500	40.1	1.07
284	13	MA1125.1	ZNF384	MA1125.1	DNWMAAAAAAAA	ZNF384	1.79e-13	2.83e-16	16800	47.2	22700	44.4	1.06
285	26	MA0093.3	USF1	MA0093.3	NDGTCATGTGACHN	USF1	1.85e-13	2.91e-16	21500	60.3	29400	57.5	1.05
286	37	MA0624.2	Nfatc1	MA0624.2	NVATGGAAAAWN	Nfatc1	2.32e-13	3.64e-16	32000	90	45100	88.2	1.02
287	26	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	5.55e-13	8.68e-16	20800	58.4	28500	55.6	1.05
288	48	MA1119.1	SIX2	MA1119.1	NNCTGAAACCTGATMY	SIX2	9.24e-13	1.44e-15	25000	70.3	34700	67.8	1.04
289	3	MA1577.1	TLX2	MA1577.1	BYAATTAR	TLX2	1.29e-12	2e-15	9040	25.4	11800	23.1	1.1
290	28	MA0906.1	HOXC12	MA0906.1	RGTCGTAAAAH	HOXC12	1.71e-12	2.65e-15	12800	36	17100	33.4	1.08
291	31	MA1508.1	IKZF1	MA1508.1	VVAACAGGAARN	IKZF1	2.23e-12	3.43e-15	35300	99.2	50500	98.7	1.01
292	55	MA0847.3	FOXD2	MA0847.3	SYTAARYAAACA	FOXD2	3.4e-12	5.22e-15	19300	54.4	26400	51.7	1.05
293	3	MA1507.1	HOXD4	MA1507.1	VTMATTAD	HOXD4	3.7e-12	5.66e-15	7900	22.2	10300	20	1.11
294	28	MA0907.1	HOXC13	MA0907.1	BCTCGTAAAAH	HOXC13	4.88e-12	7.45e-15	15600	43.8	21100	41.2	1.06
295	26	MA0829.2	SREBF1	MA0829.2	DNATCACSTGATNH	SREBF1	6.15e-12	9.35e-15	25600	72.1	35600	69.7	1.03
296	31	MA1953.1	FOXO1::ELF1	MA1953.1	RTMAACAGGAAGTN	FOXO1::ELF1	1.78e-11	2.7e-14	26000	73.1	36200	70.8	1.03
297	8	MA0613.1	FOXG1	MA0613.1	RTAAACAW	FOXG1	1.82e-11	2.75e-14	15400	43.4	20900	40.8	1.06
298	3	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	1.94e-11	2.92e-14	13000	36.4	17400	33.9	1.07
299	56	MA0101.1	REL	MA0101.1	BGGRNWTTCC	REL	2.87e-11	4.31e-14	32400	91.1	45800	89.5	1.02
300	30	MA1487.2	FOXE1	MA1487.2	VYTAAAYAAACAAH	FOXE1	3.26e-11	4.88e-14	16800	47.2	22800	44.6	1.06
301	26	MA1139.1	FOSL2::JUNB	MA1139.1	DATGACGTCATH	FOSL2::JUNB	3.8e-11	5.67e-14	19200	54	26300	51.4	1.05
302	45	MA0038.2	GFI1	MA0038.2	BMAATCACDGCA	GFI1	3.88e-11	5.76e-14	7930	22.3	10300	20.2	1.1
303	34	MA0884.2	DUXA	MA0884.2	YTRATTWAATYAR	DUXA	5.97e-11	8.84e-14	5480	15.4	6960	13.6	1.13
304	22	MA0869.2	Sox11	MA0869.2	NRGAACAAAGVV	Sox11	6.61e-11	9.76e-14	33900	95.4	48200	94.3	1.01
305	57	MA1524.2	Msgn1	MA1524.2	VRRRACAAATGGTNNN	Msgn1	8.55e-11	1.26e-13	21800	61.3	30100	58.8	1.04
306	57	MA0461.2	Atoh1	MA0461.2	RMCATATGBY	Atoh1	1.15e-10	1.69e-13	23300	65.4	32200	63	1.04
307	3	MA0702.2	LMX1A	MA0702.2	TTAATTAM	LMX1A	2.54e-10	3.71e-13	9310	26.2	12300	24	1.09
308	26	MA0043.3	HLF	MA0043.3	NNRTTATGCAACHN	HLF	3.39e-10	4.94e-13	10600	29.8	14100	27.5	1.08
309	26	MA0693.3	Vdr	MA0693.3	NNGAGTTCANN	Vdr	3.48e-10	5.05e-13	29300	82.3	41200	80.4	1.02
310	37	MA0625.2	NFATC3	MA0625.2	RYGGAAAMH	NFATC3	3.83e-10	5.54e-13	35300	99.3	50600	98.9	1
311	26	MA1126.1	FOS::JUN	MA1126.1	DRTGACGTCATHNDTN	FOS::JUN	1.04e-09	1.51e-12	28500	80.2	40100	78.3	1.03
312	28	MA1503.1	HOXB9	MA1503.1	GTCGTAAAAH	HOXB9	1.09e-09	1.57e-12	6180	17.4	7980	15.6	1.12
313	58	MA1105.2	GRHL2	MA1105.2	NRAACAGGTTYN	GRHL2	1.45e-09	2.08e-12	23600	66.2	32700	63.9	1.04
314	59	MA0479.1	FOXH1	MA0479.1	BNSAATCCACA	FOXH1	2.12e-09	3.03e-12	6870	19.3	8940	17.5	1.11
315	35	MA1114.1	PBX3	MA1114.1	NNNTGAGTGACAGGBNN	PBX3	2.49e-09	3.55e-12	13500	38.1	18300	35.8	1.06
316	21	MA0773.1	MEF2D	MA0773.1	DCTAWAAATAGM	MEF2D	3.97e-09	5.63e-12	4680	13.2	5940	11.6	1.13
317	26	MA0843.1	TEF	MA0843.1	BRTTACRTAAYM	TEF	5.46e-09	7.72e-12	9860	27.7	13100	25.6	1.08
318	35	MA0797.1	TGIF2	MA0797.1	TGACAGSTGTCA	TGIF2	6.08e-09	8.58e-12	3900	11	4890	9.56	1.15
319	42	MA1478.1	DMRTA2	MA1478.1	AATTGHTACAWT	DMRTA2	6.1e-09	8.58e-12	25200	70.7	35100	68.6	1.03
320	51	MA1151.1	RORC	MA1151.1	NWAWNTRGGTCA	RORC	6.89e-09	9.67e-12	34600	97.2	49300	96.3	1.01
321	40	MA0672.1	NKX2-3	MA0672.1	VCCACTTRAV	NKX2-3	8.28e-09	1.16e-11	22400	63	31100	60.7	1.04
322	43	MA0519.1	Stat5a::Stat5b	MA0519.1	DTTTCCMAGAA	Stat5a::Stat5b	8.83e-09	1.23e-11	18000	50.5	24700	48.2	1.05
323	26	MA0488.1	JUN	MA0488.1	DDRATGATGTCAT	JUN	1.17e-08	1.63e-11	5350	15	6870	13.4	1.12
324	35	MA1572.1	TGIF2LY	MA1572.1	TGACAGCTGTCA	TGIF2LY	1.42e-08	1.96e-11	21100	59.3	29200	57.1	1.04
325	44	MA0620.3	MITF	MA0620.3	NNNDRTCACGTGAYHNNN	MITF	2.18e-08	3.01e-11	22100	62	30600	59.8	1.04
326	43	MA0518.1	Stat4	MA0518.1	YTTCYRGGAARNVR	Stat4	2.54e-08	3.49e-11	18400	51.7	25300	49.4	1.05
327	3	MA0621.1	mix-a	MA0621.1	NDTTAATTAGN	mix-a	2.98e-08	4.08e-11	7100	20	9310	18.2	1.1
328	21	MA0660.1	MEF2B	MA0660.1	RCTAWAAATAGC	MEF2B	4.11e-08	5.62e-11	4730	13.3	6050	11.8	1.13
329	51	MA1111.1	NR2F2	MA1111.1	NAAAGGTCANR	NR2F2	6.53e-08	8.9e-11	24300	68.3	33900	66.2	1.03
330	60	MA0595.1	SREBF1	MA0595.1	VTCACCCCAY	SREBF1	1.03e-07	1.4e-10	7590	21.3	10000	19.6	1.09
331	26	MA1136.1	FOSB::JUNB	MA1136.1	RTGACGTCAT	FOSB::JUNB	1.11e-07	1.51e-10	28200	79.1	39600	77.3	1.02
332	26	MA0631.1	Six3	MA0631.1	DATRGGGTATCAYNWNT	Six3	3.49e-07	4.71e-10	14300	40.1	19500	38.1	1.05
333	61	MA1116.1	RBPJ	MA1116.1	BVTGGGAANN	RBPJ	3.91e-07	5.26e-10	30500	85.8	43100	84.3	1.02
334	30	MA0040.1	Foxq1	MA0040.1	HATTGTTTATW	Foxq1	5.43e-07	7.29e-10	10900	30.6	14700	28.7	1.07
335	8	MA0849.1	FOXO6	MA0849.1	GTAAACA	FOXO6	8.96e-07	1.2e-09	20100	56.4	27800	54.4	1.04
336	11	MA1962.1	POU2F1::SOX2	MA1962.1	MATTTRCATMACAATRG	POU2F1::SOX2	9.1e-07	1.22e-09	7300	20.5	9650	18.9	1.09
337	62	MA0525.2	TP63	MA0525.2	RACATGTYGKGACATGTC	TP63	9.89e-07	1.32e-09	285	0.8	243	0.47	1.69
338	3	MA0854.1	Alx1	MA0854.1	CGMRYTAATTARTNMNY	Alx1	1.05e-06	1.39e-09	8210	23.1	10900	21.4	1.08
339	34	MA1720.1	ZNF85	MA1720.1	DHDGAGATTACWKCAK	ZNF85	1.32e-06	1.75e-09	17500	49.2	24100	47.1	1.04
340	28	MA0873.1	HOXD12	MA0873.1	RGTCGTAAAAH	HOXD12	1.41e-06	1.86e-09	9680	27.2	13000	25.4	1.07
341	60	MA0596.1	SREBF2	MA0596.1	RTGGGGTGAY	SREBF2	1.45e-06	1.9e-09	2060	5.8	2500	4.89	1.19
342	18	MA1520.1	MAF	MA1520.1	NTGCTGASTCAGCAH	MAF	1.54e-06	2.02e-09	1620	4.55	1920	3.74	1.22
343	63	MA0689.1	TBX20	MA0689.1	WAGGTGTGAAR	TBX20	2.9e-06	3.79e-09	16100	45.2	22100	43.2	1.05
344	63	MA0800.1	EOMES	MA0800.1	RAGGTGTGAAAWN	EOMES	3.37e-06	4.39e-09	29900	83.9	42200	82.4	1.02
345	64	MA0682.2 (PITX1)	MEME-3	CTGGGATTACAGGCR	CTGGGATTACAGGCR	PITX1	4.4e-06	5.73e-09	1100	3.1	1260	2.45	1.26
346	51	MA0494.1	Nr1h3::Rxra	MA0494.1	TGACCTNNAGTRACCYYDN	Nr1h3::Rxra	5.41e-06	7e-09	24400	68.6	34200	66.8	1.03
347	40	MA0673.1	NKX2-8	MA0673.1	VCACTTSAV	NKX2-8	5.42e-06	7e-09	30700	86.4	43500	85	1.02
348	65	MA0062.3	GABPA	MA0062.3	NNCACTTCCTGTNN	GABPA	6.06e-06	7.82e-09	35300	99.1	50500	98.7	1
349	26	MA0492.1	JUND	MA0492.1	DDDRATGABGTCATN	JUND	7.53e-06	9.68e-09	5870	16.5	7720	15.1	1.09
350	17	MA0867.2	SOX4	MA0867.2	RAACAAAGRV	SOX4	1.31e-05	1.67e-08	11700	32.9	15900	31.1	1.06
351	23	MA0484.2	HNF4G	MA0484.2	DNCAAAGTCCANN	HNF4G	1.31e-05	1.67e-08	11200	31.6	15300	29.8	1.06
352	26	MA1129.1	FOSL1::JUN	MA1129.1	ATGACGTCAT	FOSL1::JUN	1.78e-05	2.27e-08	31300	88	44400	86.7	1.01
353	62	MA0106.3	TP53	MA0106.3	RACATGYCCGGRCATGTY	TP53	1.89e-05	2.41e-08	127	0.36	85	0.17	2.14
354	17	MA0087.2	Sox5	MA0087.2	VRVAACAATGGNN	Sox5	1.93e-05	2.45e-08	15900	44.8	22000	42.9	1.04
355	44	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	2.85e-05	3.6e-08	5090	14.3	6670	13	1.1
356	44	MA0743.2	SCRT1	MA0743.2	NDWKCAACAGGTGKNN	SCRT1	2.87e-05	3.61e-08	29100	81.7	41000	80.2	1.02
357	57	MA0827.1	OLIG3	MA0827.1	AMCATATGBY	OLIG3	3.12e-05	3.92e-08	27100	76.1	38100	74.5	1.02
358	26	MA0639.1	DBP	MA0639.1	NRTTACGTAAYV	DBP	3.13e-05	3.92e-08	7090	19.9	9450	18.5	1.08
359	29	MA0502.2	NFYB	MA0502.2	CYCATTGGCCVV	NFYB	3.24e-05	4.04e-08	8530	24	11500	22.4	1.07
360	63	MA0802.1	TBR1	MA0802.1	AGGTGTGAAA	TBR1	3.43e-05	4.28e-08	28100	78.9	39600	77.3	1.02
361	41	MA1643.1	NFIB	MA1643.1	NNCCTGGCAYNGTGCCAAGNN	NFIB	3.59e-05	4.46e-08	2290	6.44	2850	5.56	1.16
362	27	MA0838.1	CEBPG	MA0838.1	ATTRCGCAAY	CEBPG	3.64e-05	4.51e-08	2060	5.79	2540	4.96	1.17
363	44	MA1635.1	BHLHE22	MA1635.1	NVCAGCTGBN	BHLHE22	4.38e-05	5.41e-08	5180	14.6	6800	13.3	1.1
364	66	MA0069.1	PAX6	MA0069.1	TTCACGCWTSANTK	PAX6	5.96e-05	7.34e-08	17300	48.7	24000	46.9	1.04
365	67	MA0080.6 (Spi1)	MEME-5	CWBYCTYCCTCTSTC	CWBYCTYCCTCTSTC	Spi1	8.45e-05	1.04e-07	14800	41.5	20300	39.7	1.04
366	57	MA1618.1	Ptf1a	MA1618.1	NNACAGATGTTNN	Ptf1a	9.55e-05	1.17e-07	26600	74.6	37400	73.1	1.02
367	23	MA0114.4	HNF4A	MA0114.4	DNCAAAGTCCANN	HNF4A	9.89e-05	1.21e-07	15800	44.5	21900	42.7	1.04
368	26	MA0592.3	ESRRA	MA0592.3	NBTCAAGGTCAHN	ESRRA	0.000128	1.55e-07	32300	90.7	45900	89.6	1.01
369	26	MA1133.1	JUN::JUNB	MA1133.1	KRTGACGTCATN	JUN::JUNB	0.000137	1.67e-07	24900	69.9	34900	68.2	1.02
370	34	MA0468.1	DUX4	MA0468.1	TAAYYYAATCA	DUX4	0.000208	2.52e-07	3530	9.93	4560	8.92	1.11
371	44	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	0.000213	2.58e-07	4890	13.8	6440	12.6	1.09
372	12	MA0683.1	POU4F2	MA0683.1	RTGCATAATTAATGAG	POU4F2	0.00051	6.16e-07	1980	5.57	2470	4.83	1.15
373	26	MA0629.1	Rhox11	MA0629.1	ANKNCGCTGTWAWDVRW	Rhox11	0.000564	6.78e-07	18100	50.8	25100	49.1	1.03
374	26	MA1996.1	Nr1H2	MA1996.1	NNRAGGTCANN	Nr1H2	0.000566	6.79e-07	33200	93.4	47400	92.6	1.01
375	35	MA1571.1	TGIF2LX	MA1571.1	TGACAGCTGTCA	TGIF2LX	0.00057	6.82e-07	14600	41	20100	39.4	1.04
376	52	MA0691.1	TFAP4	MA0691.1	AWCAGCTGWT	TFAP4	0.000599	7.15e-07	1240	3.48	1480	2.89	1.2
377	26	MA1145.1	FOSL2::JUND	MA1145.1	NNRTGACGTCAYHSN	FOSL2::JUND	0.000748	8.9e-07	21700	61.1	30400	59.5	1.03
378	68	MA0029.1	Mecom	MA0029.1	AAGAYAAGATAANA	Mecom	0.000752	8.93e-07	3100	8.72	4000	7.81	1.12
379	69	MA0687.1	SPIC	MA0687.1	HAAAAGVGGAAGTA	SPIC	0.000899	1.06e-06	27400	76.9	38600	75.5	1.02
380	41	MA0698.1	ZBTB18	MA0698.1	NATCCAGATGTKB	ZBTB18	0.00129	1.53e-06	11800	33.2	16200	31.7	1.05
381	41	MA1123.2	TWIST1	MA1123.2	NNDCCAGATGTBN	TWIST1	0.00195	2.3e-06	20500	57.6	28700	56	1.03
382	70	MA1989.1	Bcl11B	MA1989.1	NNAAACCACAARNN	Bcl11B	0.00254	2.99e-06	30800	86.4	43700	85.4	1.01
383	71	MA0160.2	NR4A2	MA0160.2	BWAAAGGTCA	NR4A2	0.00327	3.83e-06	27100	76.2	38300	74.8	1.02
384	72	MA0161.2	NFIC	MA0161.2	NNCTTGGCANN	NFIC	0.00395	4.61e-06	33100	93	47200	92.2	1.01
385	8	MA0614.1	Foxj2	MA0614.1	RTAAACAA	Foxj2	0.00492	5.74e-06	3820	10.7	5020	9.82	1.09
386	18	MA1521.1	MAFA	MA1521.1	NTGCTGASTCAGCAN	MAFA	0.00615	7.14e-06	915	2.57	1080	2.12	1.21
387	73	MA0119.1	NFIC::TLX1	MA0119.1	TGGCASSRWGCCAA	NFIC::TLX1	0.00662	7.68e-06	1710	4.8	2140	4.18	1.15
388	74	MA1977.1	ZNF324	MA1977.1	NNNWRGMAGHYAAGGATGGTT	ZNF324	0.00668	7.72e-06	13800	38.8	19100	37.4	1.04
389	51	MA0071.1	RORA	MA0071.1	AWMWAGGTCA	RORA	0.0119	1.37e-05	9730	27.4	13300	26.1	1.05
390	33	MA1561.1	SOX12	MA1561.1	ACCGAACAATV	SOX12	0.0122	1.41e-05	19500	54.7	27300	53.3	1.03
391	17	MA0515.1	Sox6	MA0515.1	CCWTTGTYYY	Sox6	0.0124	1.42e-05	3140	8.83	4110	8.02	1.1
392	63	MA0688.1	TBX2	MA0688.1	DAGGTGTGAAA	TBX2	0.013	1.49e-05	30900	86.8	43900	85.8	1.01
393	75	MA0508.3	PRDM1	MA0508.3	YNCTTTCTCTH	PRDM1	0.015	1.71e-05	13500	38	18800	36.6	1.04
394	76	MA0520.1	Stat6	MA0520.1	BDBTTCCWSAGAAVY	Stat6	0.0187	2.13e-05	10100	28.4	13900	27.1	1.05
395	77	MA0780.1	PAX3	MA0780.1	TAATYRATTA	PAX3	0.0208	2.36e-05	5620	15.8	7560	14.8	1.07
396	65	MA0640.2	ELF3	MA0640.2	NNCCACTTCCTGNT	ELF3	0.0217	2.46e-05	34100	95.9	48800	95.4	1.01
397	51	MA1148.1	PPARA::RXRA	MA1148.1	AWNTRGGTYAAAGGTCAN	PPARA::RXRA	0.0224	2.53e-05	24200	68	34100	66.7	1.02
398	73	MA1528.1	NFIX	MA1528.1	STTGGCRNNGTGCCARB	NFIX	0.0252	2.84e-05	2050	5.76	2620	5.13	1.12
399	28	MA1506.1	HOXD10	MA1506.1	RGTCGTAAAAH	HOXD10	0.031	3.49e-05	2970	8.35	3890	7.61	1.1
400	35	MA0796.1	TGIF1	MA0796.1	TGACAGCTGTCA	TGIF1	0.0346	3.88e-05	1070	3	1310	2.55	1.18
401	3	MA0135.1	Lhx3	MA0135.1	WAATTAATTAWYY	Lhx3	0.0355	3.97e-05	5570	15.7	7510	14.7	1.07
402	78	MA0083.3	SRF	MA0083.3	TGMCCATATATGGKCA	SRF	0.0361	4.03e-05	455	1.28	507	0.99	1.29
403	71	MA1541.1	NR6A1	MA1541.1	NYCAAGKTCAAGKTCAN	NR6A1	0.0365	4.06e-05	23300	65.4	32800	64.1	1.02
13	79	MA0528.2 (ZNF263)	STREME-10	10-CCTCCTCCCACCCC	10-CCTCCTCCCACCCC	ZNF263	0.0368	0.00283	73	0.21	64	0.13	1.64
14	80	8-TGCCTGCCAS	STREME-8	8-TGCCTGCCAS	TGCCTGCCAS	TGCCTGCCAS	0.0485	0.00346	5690	16	7840	15.3	1.04
15	79	MA1596.1 (ZNF460)	MEME-4	GGRGGCKGRGGCDGG	GGRGGCKGRGGCDGG	ZNF460	5.57	0.371	96	0.27	131	0.26	1.06

ER_rat <- 1.25

DOX_24_20kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DOX_24_20kb_combo response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DOX_24_20kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*9), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./9,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DOX_24_20kb_combo response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

Other treaments

EPI

EPI_DAR_3hr data

EPI_DAR_3hr_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_3_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
EPI_DAR_3hr_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_3_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
EPI_DAR_3hr_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_3_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
EPI_DAR_3hr_all <- rbind(EPI_DAR_3hr_sea_disc, EPI_DAR_3hr_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

EPI_DAR_3hr_combo <- EPI_DAR_3hr_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., EPI_DAR_3hr_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ NA_character_
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="EPI_DAR_3hr")

EPI_DAR_3hr_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs in 3 hour EPI-DAR v 3 hour non-EPI DAR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs in 3 hour EPI-DAR v 3 hour non-EPI DAR
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA1961.1 (PATZ1)	MEME-1	CCCVSCCCCGCCCCC	CCCVSCCCCGCCCCC	PATZ1	6.82e-286	4.49e-286	6590	51.5	44500	35	1.47	EPI_DAR_3hr
2	1	MA1511.2 (KLF10)	STREME-1	1-CCCCGCCCCCGCC	CCCCGCCCCCGCC	KLF10	8.01e-283	2.64e-283	5800	45.3	37300	29.4	1.54	EPI_DAR_3hr
3	1	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	1.99e-237	4.36e-238	5020	39.2	32000	25.1	1.56	EPI_DAR_3hr
4	2	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	1.35e-233	2.22e-234	6260	48.9	43300	34	1.44	EPI_DAR_3hr
5	1	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	2.33e-227	3.06e-228	4560	35.6	28300	22.3	1.6	EPI_DAR_3hr
6	1	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	2.78e-220	3.05e-221	5420	42.3	36100	28.4	1.49	EPI_DAR_3hr
7	1	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	3.87e-219	3.64e-220	4670	36.5	29600	23.3	1.57	EPI_DAR_3hr
8	3	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	5.2e-211	4.28e-212	5310	41.4	35500	27.9	1.49	EPI_DAR_3hr
9	1	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	2.27e-209	1.66e-210	5970	46.6	41500	32.6	1.43	EPI_DAR_3hr
10	1	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	8.84e-205	5.82e-206	6400	50	45800	36	1.39	EPI_DAR_3hr
11	1	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	5.94e-203	3.55e-204	6590	51.4	47600	37.4	1.37	EPI_DAR_3hr
12	1	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	4.23e-200	2.32e-201	6560	51.2	47400	37.3	1.37	EPI_DAR_3hr
13	4	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	5.67e-200	2.87e-201	6950	54.3	51200	40.3	1.35	EPI_DAR_3hr
14	5	6-CCGGCC	STREME-6	6-CCGGCC	CCGGCC	CCGGCC	6.36e-188	2.99e-189	5850	45.7	41300	32.5	1.41	EPI_DAR_3hr
15	1	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	5.1e-186	2.24e-187	7020	54.8	52500	41.3	1.33	EPI_DAR_3hr
16	1	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	1.31e-184	5.37e-186	6990	54.6	52300	41.1	1.33	EPI_DAR_3hr
17	6	2-CGGSSCCG	STREME-2	2-CGGSSCCG	CGGSSCCG	CGGSSCCG	4.24e-183	1.64e-184	6800	53.1	50500	39.7	1.34	EPI_DAR_3hr
18	7	3-CCGSCGG	STREME-3	3-CCGSCGG	CCGSCGG	CCGSCGG	4.54e-183	1.66e-184	5860	45.8	41700	32.8	1.4	EPI_DAR_3hr
19	1	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	6.75e-180	2.26e-181	6280	49	45700	35.9	1.36	EPI_DAR_3hr
20	1	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	6.86e-180	2.26e-181	4810	37.5	32200	25.4	1.48	EPI_DAR_3hr
21	1	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	1.89e-179	5.92e-181	6800	53.1	50700	39.8	1.33	EPI_DAR_3hr
22	4	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	5.38e-179	1.61e-180	6170	48.2	44700	35.2	1.37	EPI_DAR_3hr
23	4	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	1.67e-176	4.79e-178	6470	50.5	47700	37.5	1.35	EPI_DAR_3hr
24	1	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	1.84e-170	5.04e-172	5800	45.3	41600	32.7	1.38	EPI_DAR_3hr
25	8	MA0742.2 (KLF12)	STREME-4	4-CGCCCC	CGCCCC	KLF12	1.57e-167	4.13e-169	6920	54	52300	41.2	1.31	EPI_DAR_3hr
26	1	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	1.5e-164	3.8e-166	7640	59.6	59600	46.9	1.27	EPI_DAR_3hr
27	1	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	3.43e-162	8.35e-164	7450	58.1	57800	45.5	1.28	EPI_DAR_3hr
28	19	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	3.73e-161	8.77e-163	6080	47.4	44600	35.1	1.35	EPI_DAR_3hr
29	1	MA0079.5 (SP1)	STREME-5	5-CCCCGC	CCCCGC	SP1	1.24e-157	2.82e-159	5580	43.6	40200	31.6	1.38	EPI_DAR_3hr
30	1	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	5.97e-153	1.31e-154	4690	36.6	32300	25.4	1.44	EPI_DAR_3hr
31	9	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	2.37e-151	5.03e-153	6960	54.3	53600	42.1	1.29	EPI_DAR_3hr
32	10	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	9.66e-151	1.99e-152	6040	47.2	44800	35.2	1.34	EPI_DAR_3hr
33	4	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	2.92e-150	5.83e-152	7150	55.8	55500	43.6	1.28	EPI_DAR_3hr
34	10	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	2.68e-149	5.19e-151	6860	53.6	52700	41.4	1.29	EPI_DAR_3hr
35	11	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	1.53e-144	2.87e-146	6310	49.3	47700	37.5	1.31	EPI_DAR_3hr
36	12	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	1.41e-143	2.57e-145	7060	55.1	55000	43.2	1.28	EPI_DAR_3hr
37	13	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	4.85e-141	8.62e-143	5310	41.4	38400	30.2	1.37	EPI_DAR_3hr
38	4	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	1.66e-139	2.87e-141	8720	68.1	72000	56.6	1.2	EPI_DAR_3hr
39	14	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	1.56e-138	2.63e-140	6960	54.3	54200	42.6	1.27	EPI_DAR_3hr
40	4	MA0732.1	EGR3	MA0732.1	HHMCGCCCACGCAHH	EGR3	5.48e-136	9.02e-138	3480	27.2	22500	17.7	1.53	EPI_DAR_3hr
41	15	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	6.96e-136	1.12e-137	3390	26.4	21700	17.1	1.55	EPI_DAR_3hr
42	4	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	8.03e-136	1.26e-137	5900	46	44200	34.7	1.33	EPI_DAR_3hr
43	16	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	3.23e-135	4.94e-137	6360	49.6	48600	38.2	1.3	EPI_DAR_3hr
44	10	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	3.11e-134	4.66e-136	7790	60.8	62700	49.3	1.23	EPI_DAR_3hr
45	17	MA1578.1	VEZF1	MA1578.1	CCCCCCMYDH	VEZF1	2.62e-128	3.83e-130	7740	60.4	62500	49.2	1.23	EPI_DAR_3hr
46	18	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	2.81e-126	4.02e-128	5210	40.7	38300	30.1	1.35	EPI_DAR_3hr
47	12	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	1.7e-125	2.38e-127	8410	65.6	69500	54.7	1.2	EPI_DAR_3hr
48	4	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	2.55e-124	3.5e-126	5200	40.6	38300	30.1	1.35	EPI_DAR_3hr
49	19	MA1653.1 (ZNF148)	STREME-8	8-CCCCTCC	CCCCTCC	ZNF148	8.15e-121	1.09e-122	8020	62.6	65800	51.8	1.21	EPI_DAR_3hr
50	20	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	6.19e-120	8.15e-122	7640	59.6	62000	48.7	1.22	EPI_DAR_3hr
51	21	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	1.3e-118	1.67e-120	7780	60.7	63500	49.9	1.22	EPI_DAR_3hr
52	4	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	1.41e-114	1.79e-116	6000	46.9	46300	36.4	1.29	EPI_DAR_3hr
53	22	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	1.8e-114	2.23e-116	7150	55.8	57400	45.2	1.24	EPI_DAR_3hr
54	23	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	9.38e-112	1.14e-113	9240	72.2	79100	62.2	1.16	EPI_DAR_3hr
55	24	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	6.8e-108	8.14e-110	5070	39.6	37900	29.8	1.33	EPI_DAR_3hr
56	25	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	3.38e-107	3.97e-109	5590	43.6	42800	33.6	1.3	EPI_DAR_3hr
57	21	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	2.22e-105	2.57e-107	7200	56.2	58500	46	1.22	EPI_DAR_3hr
58	26	MA0528.2	ZNF263	MA0528.2	VNGGGGAGGASG	ZNF263	5.08e-105	5.76e-107	5460	42.6	41700	32.8	1.3	EPI_DAR_3hr
59	27	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	9.85e-105	1.1e-106	7410	57.8	60600	47.6	1.21	EPI_DAR_3hr
60	10	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	3.34e-103	3.66e-105	7530	58.8	61900	48.7	1.21	EPI_DAR_3hr
61	9	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	3.52e-97	3.8e-99	6440	50.2	51500	40.5	1.24	EPI_DAR_3hr
62	23	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	8.39e-97	8.91e-99	9380	73.2	81400	64	1.14	EPI_DAR_3hr
63	23	MA0872.1	TFAP2A	MA0872.1	TGCCCYSRGGGCA	TFAP2A	3.15e-96	3.29e-98	3800	29.6	27000	21.3	1.39	EPI_DAR_3hr
64	28	MA0597.2	THAP1	MA0597.2	VSGCAGGGCASV	THAP1	1.31e-94	1.35e-96	7970	62.2	66900	52.6	1.18	EPI_DAR_3hr
65	29	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	1.71e-94	1.73e-96	7140	55.8	58600	46.1	1.21	EPI_DAR_3hr
66	30	MA0799.2 (RFX4)	STREME-9	9-GCCWGGC	GCCWGGC	RFX4	3.66e-93	3.65e-95	5650	44.1	44200	34.8	1.27	EPI_DAR_3hr
67	23	MA0815.1	TFAP2C	MA0815.1	TGCCCYSRGGGCA	TFAP2C	4.25e-93	4.17e-95	3320	25.9	23000	18.1	1.43	EPI_DAR_3hr
68	21	MA1569.1	TFAP2E	MA1569.1	YGCCYSRGGCD	TFAP2E	7.55e-93	7.31e-95	2570	20	16600	13.1	1.53	EPI_DAR_3hr
69	31	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	4.81e-91	4.58e-93	8260	64.5	70100	55.1	1.17	EPI_DAR_3hr
70	32	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	6.8e-91	6.4e-93	8040	62.8	67900	53.4	1.18	EPI_DAR_3hr
71	12	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	6.53e-90	6.05e-92	6270	49	50400	39.6	1.24	EPI_DAR_3hr
72	23	MA0813.1	TFAP2B	MA0813.1	TGCCCYBRGGGCA	TFAP2B	3.82e-89	3.49e-91	3190	24.9	22100	17.4	1.43	EPI_DAR_3hr
73	1	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	6.28e-86	5.66e-88	1880	14.6	11300	8.89	1.65	EPI_DAR_3hr
74	17	MA0736.1	GLIS2	MA0736.1	GACCCCCCGCRAMG	GLIS2	1.58e-85	1.41e-87	5080	39.7	39300	30.9	1.28	EPI_DAR_3hr
75	23	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	2.22e-85	1.95e-87	3170	24.8	22100	17.4	1.42	EPI_DAR_3hr
76	21	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	1.28e-84	1.11e-86	5190	40.5	40400	31.8	1.28	EPI_DAR_3hr
77	33	MA1648.1	TCF12	MA1648.1	NNCACCTGCNN	TCF12	4.76e-82	4.07e-84	7250	56.6	60500	47.6	1.19	EPI_DAR_3hr
78	34	MA1719.1	ZNF816	MA1719.1	DRRKGGGGACATGCHGGG	ZNF816	6.23e-82	5.25e-84	8220	64.2	70300	55.3	1.16	EPI_DAR_3hr
79	33	MA0522.3	TCF3	MA0522.3	NVCACCTGCNN	TCF3	1.69e-81	1.41e-83	8140	63.5	69500	54.6	1.16	EPI_DAR_3hr
80	29	MA0024.3	E2F1	MA0024.3	TTTGGCGCCAAA	E2F1	2.52e-81	2.07e-83	3850	30.1	28300	22.3	1.35	EPI_DAR_3hr
81	35	MA0751.1	ZIC4	MA0751.1	GRCCCCCCGCKGYGH	ZIC4	6.79e-79	5.52e-81	7860	61.3	66800	52.5	1.17	EPI_DAR_3hr
82	33	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	4.72e-78	3.79e-80	5230	40.8	41200	32.4	1.26	EPI_DAR_3hr
83	31	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	9.97e-78	7.91e-80	7540	58.8	63700	50.1	1.18	EPI_DAR_3hr
84	36	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	6.65e-76	5.21e-78	4050	31.6	30400	23.9	1.32	EPI_DAR_3hr
85	4	MA1656.1	ZNF449	MA1656.1	NNAAGCCCAACCNN	ZNF449	4.32e-75	3.35e-77	7310	57.1	61600	48.4	1.18	EPI_DAR_3hr
86	29	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	1.22e-71	9.31e-74	4620	36	35900	28.2	1.28	EPI_DAR_3hr
87	33	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	4.71e-71	3.56e-73	3740	29.2	27900	22	1.33	EPI_DAR_3hr
88	29	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	4.11e-70	3.07e-72	4430	34.6	34300	27	1.28	EPI_DAR_3hr
89	33	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	2.87e-67	2.12e-69	6170	48.2	50900	40	1.2	EPI_DAR_3hr
90	37	7-GCGYCW	STREME-7	7-GCGYCW	GCGYCW	GCGYCW	3.71e-67	2.71e-69	9940	77.6	89400	70.3	1.1	EPI_DAR_3hr
91	38	MA1985.1	ZNF669	MA1985.1	GGGGYGAYGACCRCT	ZNF669	1.03e-65	7.48e-68	3720	29	28000	22	1.32	EPI_DAR_3hr
92	33	MA1106.1	HIF1A	MA1106.1	SBACGTGCNN	HIF1A	4.16e-65	2.97e-67	6950	54.2	58700	46.2	1.17	EPI_DAR_3hr
93	24	MA0155.1	INSM1	MA0155.1	TGYCWGGGGGCR	INSM1	1.78e-64	1.26e-66	3910	30.5	29900	23.5	1.3	EPI_DAR_3hr
94	39	MA1727.1	ZNF417	MA1727.1	VRBVNTGGGCGCCAM	ZNF417	2.26e-61	1.58e-63	4670	36.4	37100	29.2	1.25	EPI_DAR_3hr
95	26	MA1987.1	ZNF701	MA1987.1	GAGCACYAARGGGGGRADDDD	ZNF701	1.11e-59	7.71e-62	9000	70.2	80000	62.9	1.12	EPI_DAR_3hr
96	13	MA1587.1	ZNF135	MA1587.1	CCTCGACCTCCYRR	ZNF135	3.23e-57	2.22e-59	6560	51.2	55500	43.6	1.17	EPI_DAR_3hr
97	33	MA1628.1	Zic1::Zic2	MA1628.1	CVCAGCAGGNV	Zic1::Zic2	7.75e-57	5.26e-59	4690	36.6	37600	29.6	1.24	EPI_DAR_3hr
98	29	MA0864.2	E2F2	MA0864.2	RWTTTGGCGCCAWWWY	E2F2	1.48e-55	9.95e-58	4520	35.2	36100	28.4	1.24	EPI_DAR_3hr
99	33	MA1945.1	ETV5::FIGLA	MA1945.1	RGCGGAARCAGGTGG	ETV5::FIGLA	1.53e-55	1.02e-57	5710	44.6	47400	37.3	1.2	EPI_DAR_3hr
100	40	MA1710.1	ZNF257	MA1710.1	VDGAGGCRAGRG	ZNF257	2.73e-55	1.79e-57	6060	47.3	50800	40	1.18	EPI_DAR_3hr
101	33	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	1.36e-54	8.88e-57	5480	42.8	45300	35.6	1.2	EPI_DAR_3hr
102	31	MA0695.1	ZBTB7C	MA0695.1	RCGACCACCGAN	ZBTB7C	3.77e-54	2.43e-56	6470	50.5	54900	43.2	1.17	EPI_DAR_3hr
103	31	MA0694.1	ZBTB7B	MA0694.1	RCGACCACCGAA	ZBTB7B	1.8e-53	1.15e-55	3640	28.4	28200	22.2	1.28	EPI_DAR_3hr
104	33	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	1.12e-52	7.1e-55	9360	73.1	84400	66.4	1.1	EPI_DAR_3hr
105	41	MA1972.1	ZFP14	MA1972.1	GGAGGCHCHGGARBG	ZFP14	3.09e-52	1.94e-54	7320	57.1	63500	49.9	1.14	EPI_DAR_3hr
106	42	MA0615.1	Gmeb1	MA0615.1	BHBBKKACGTMMNWNNN	Gmeb1	8.94e-52	5.55e-54	3460	27	26600	21	1.29	EPI_DAR_3hr
107	43	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	3.52e-51	2.17e-53	4980	38.8	40700	32	1.21	EPI_DAR_3hr
108	33	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	3.96e-50	2.41e-52	4280	33.4	34300	27	1.24	EPI_DAR_3hr
109	33	MA0147.3	MYC	MA0147.3	NNCCACGTGCNB	MYC	8.81e-50	5.32e-52	6320	49.3	53800	42.3	1.17	EPI_DAR_3hr
110	33	MA1631.1	ASCL1	MA1631.1	NNGCACCTGCYNB	ASCL1	7.43e-49	4.45e-51	4410	34.4	35600	28	1.23	EPI_DAR_3hr
111	33	MA0616.2	HES2	MA0616.2	GGCACGTGYC	HES2	1.09e-48	6.45e-51	4540	35.4	36800	28.9	1.22	EPI_DAR_3hr
112	44	MA1528.1	NFIX	MA1528.1	STTGGCRNNGTGCCARB	NFIX	3.8e-48	2.23e-50	3340	26.1	25800	20.3	1.29	EPI_DAR_3hr
113	45	MA0259.1	ARNT::HIF1A	MA0259.1	VBACGTGC	ARNT::HIF1A	6.09e-48	3.55e-50	4600	35.9	37400	29.4	1.22	EPI_DAR_3hr
114	35	MA0696.1	ZIC1	MA0696.1	GACCCCCYGCTGTG	ZIC1	3.23e-47	1.86e-49	3380	26.4	26200	20.6	1.28	EPI_DAR_3hr
115	26	MA1728.1	ZNF549	MA1728.1	NNTGCTGCCCWR	ZNF549	1.53e-46	8.74e-49	6430	50.2	55200	43.4	1.16	EPI_DAR_3hr
116	46	MA1982.1	ZNF574	MA1982.1	VGSCTAGAGMGGCCS	ZNF574	2.7e-45	1.53e-47	8280	64.6	73800	58	1.11	EPI_DAR_3hr
117	33	MA1099.2	HES1	MA1099.2	GGCRCGTGBC	HES1	3.45e-45	1.94e-47	2470	19.3	18300	14.4	1.35	EPI_DAR_3hr
118	33	MA0104.4	MYCN	MA0104.4	VVCCACGTGGBB	MYCN	3.66e-45	2.04e-47	8760	68.4	78800	61.9	1.1	EPI_DAR_3hr
119	33	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	3.72e-45	2.06e-47	4130	32.2	33300	26.2	1.23	EPI_DAR_3hr
120	47	MA1637.1	EBF3	MA1637.1	NYCCCAAGGGANN	EBF3	3.98e-45	2.19e-47	8690	67.8	78000	61.4	1.11	EPI_DAR_3hr
121	36	MA0750.2	ZBTB7A	MA0750.2	NVCCGGAAGTGSV	ZBTB7A	4.22e-45	2.3e-47	2460	19.2	18100	14.2	1.35	EPI_DAR_3hr
122	33	MA0103.3	ZEB1	MA0103.3	SNCACCTGSVN	ZEB1	9.58e-45	5.17e-47	7900	61.6	70000	55	1.12	EPI_DAR_3hr
123	33	MA1966.1	TFAP4::ETV1	MA1966.1	RSCGGAAGCAGSTGKN	TFAP4::ETV1	4.69e-44	2.51e-46	2550	19.9	19000	15	1.33	EPI_DAR_3hr
124	48	MA1684.1	Foxn1	MA1684.1	RGAMGC	Foxn1	6.31e-44	3.35e-46	1880	14.7	13200	10.4	1.41	EPI_DAR_3hr
125	49	MA0504.1	NR2C2	MA0504.1	VGRGGTCARAGGTCA	NR2C2	8.85e-43	4.66e-45	7460	58.3	65800	51.7	1.13	EPI_DAR_3hr
126	35	MA1584.1	ZIC5	MA1584.1	VGACCCCCCGCTGHGM	ZIC5	9.42e-43	4.92e-45	1670	13	11500	9.02	1.44	EPI_DAR_3hr
127	9	MA0163.1	PLAG1	MA0163.1	GGGGCCCWAGGGGG	PLAG1	2.58e-41	1.34e-43	1810	14.1	12800	10	1.41	EPI_DAR_3hr
128	33	MA1941.1	ETV2::FIGLA	MA1941.1	RSCGGAARCAGSTGBN	ETV2::FIGLA	1.95e-40	1e-42	8700	67.9	78500	61.8	1.1	EPI_DAR_3hr
129	33	MA1635.1	BHLHE22	MA1635.1	NVCAGCTGBN	BHLHE22	3.16e-40	1.61e-42	4290	33.5	35200	27.7	1.21	EPI_DAR_3hr
130	50	MA1964.1	SMAD2	MA1964.1	NBCCAGACDN	SMAD2	1.14e-38	5.79e-41	6030	47.1	52000	40.9	1.15	EPI_DAR_3hr
131	51	MA1973.1	ZKSCAN3	MA1973.1	KDKCCCAGGCTAGCCCABNN	ZKSCAN3	1.77e-38	8.9e-41	5000	39	42100	33.1	1.18	EPI_DAR_3hr
132	29	MA0470.2	E2F4	MA0470.2	TTTTGGCGCCAWWW	E2F4	2.46e-38	1.23e-40	2750	21.5	21200	16.7	1.29	EPI_DAR_3hr
133	44	MA1643.1	NFIB	MA1643.1	NNCCTGGCAYNGTGCCAAGNN	NFIB	1.07e-35	5.28e-38	4620	36.1	38800	30.5	1.18	EPI_DAR_3hr
134	52	MA1726.1	ZNF331	MA1726.1	NMYTGCAGAGCCCH	ZNF331	1.35e-35	6.64e-38	8930	69.7	81500	64	1.09	EPI_DAR_3hr
135	47	MA0154.4	EBF1	MA0154.4	NNTCCCCAGGGGANN	EBF1	8.79e-35	4.28e-37	8880	69.4	81000	63.7	1.09	EPI_DAR_3hr
136	53	MA1474.1	CREB3L4	MA1474.1	YGCCACGTCAYC	CREB3L4	1.73e-34	8.36e-37	3540	27.6	28700	22.5	1.23	EPI_DAR_3hr
137	54	MA0767.1	GCM2	MA0767.1	BATGCGGGTR	GCM2	3.51e-34	1.69e-36	3080	24	24500	19.3	1.25	EPI_DAR_3hr
138	36	MA0765.3	ETV5	MA0765.3	ACCGGAAGTR	ETV5	5.32e-34	2.54e-36	4800	37.5	40600	32	1.17	EPI_DAR_3hr
139	47	MA1604.1	Ebf2	MA1604.1	NYCCCAAGGGANN	Ebf2	3.06e-33	1.45e-35	8870	69.2	81000	63.7	1.09	EPI_DAR_3hr
140	36	MA0764.3	ETV4	MA0764.3	ACCGGAAGTR	ETV4	3.38e-33	1.59e-35	8510	66.4	77300	60.8	1.09	EPI_DAR_3hr
141	55	MA1149.1	RARA::RXRG	MA1149.1	RRGGTCAHNNNRRGGTCA	RARA::RXRG	1.28e-31	5.95e-34	8820	68.8	80700	63.5	1.08	EPI_DAR_3hr
142	54	MA0646.1	GCM1	MA0646.1	BATGCGGGTAC	GCM1	1.35e-30	6.24e-33	5010	39.1	43000	33.8	1.16	EPI_DAR_3hr
143	33	MA0697.2	Zic3	MA0697.2	CNCAGCAGGAGNN	Zic3	6.24e-29	2.87e-31	10000	78	93300	73.4	1.06	EPI_DAR_3hr
144	56	MA1730.1	ZNF708	MA1730.1	NNRGCTGTRCCTCCY	ZNF708	4.68e-28	2.14e-30	9120	71.2	84200	66.2	1.08	EPI_DAR_3hr
145	33	MA1629.1	Zic2	MA1629.1	NDCACAGCAGGDRG	Zic2	1.54e-27	7.01e-30	10400	81.2	97800	76.9	1.06	EPI_DAR_3hr
146	57	MA1711.1	ZNF343	MA1711.1	CCGCTTCMCCDCGGCMV	ZNF343	1.51e-26	6.78e-29	2800	21.9	22600	17.8	1.23	EPI_DAR_3hr
147	45	MA0006.1	Ahr::Arnt	MA0006.1	YGCGTG	Ahr::Arnt	7.76e-26	3.47e-28	1790	14	13600	10.7	1.31	EPI_DAR_3hr
148	43	MA0067.2	PAX2	MA0067.2	BCAVTSRAGCGTGACGR	PAX2	1.22e-25	5.41e-28	3090	24.1	25300	19.9	1.21	EPI_DAR_3hr
149	24	MA1929.1	CTCF	MA1929.1	CTGCAGTKCCNNNNNYNRCCASYAGRKGGCRSWG	CTCF	1.14e-24	5.02e-27	3480	27.1	29000	22.8	1.19	EPI_DAR_3hr
150	33	MA0649.1	HEY2	MA0649.1	GRCACGTGYC	HEY2	6.47e-24	2.84e-26	1950	15.2	15100	11.9	1.28	EPI_DAR_3hr
151	58	MA0511.2	RUNX2	MA0511.2	WAACCGCAA	RUNX2	1.58e-23	6.87e-26	9250	72.2	86100	67.7	1.07	EPI_DAR_3hr
152	33	MA0499.2	MYOD1	MA0499.2	NNGCACCTGTCNB	MYOD1	3.81e-23	1.65e-25	6820	53.2	61500	48.4	1.1	EPI_DAR_3hr
153	59	MA1529.1	NHLH2	MA1529.1	GGGNCGCAGCTGCGYCCC	NHLH2	4.65e-23	2e-25	3050	23.8	25200	19.8	1.2	EPI_DAR_3hr
154	60	MA0738.1	HIC2	MA0738.1	RTGCCCRSB	HIC2	2.88e-22	1.23e-24	11600	90.6	111000	87.6	1.03	EPI_DAR_3hr
155	61	MA0145.2	Tfcp2l1	MA0145.2	CCAGYYYVADCCRG	Tfcp2l1	3.08e-22	1.31e-24	2790	21.8	22900	18	1.21	EPI_DAR_3hr
156	62	MA1971.1	ZBED2	MA1971.1	NNMMCGAAACCNNV	ZBED2	3.54e-22	1.49e-24	702	5.48	4530	3.56	1.54	EPI_DAR_3hr
157	63	MA1979.1	ZNF416	MA1979.1	TATCTGGGCAH	ZNF416	2.4e-21	1.01e-23	8890	69.4	82600	65	1.07	EPI_DAR_3hr
158	36	MA0028.2	ELK1	MA0028.2	ACCGGAAGTR	ELK1	3.12e-21	1.3e-23	5530	43.2	49100	38.6	1.12	EPI_DAR_3hr
159	49	MA1535.1	NR2C1	MA1535.1	NRRGGTCAN	NR2C1	5.4e-21	2.23e-23	10900	85.2	104000	81.8	1.04	EPI_DAR_3hr
160	64	MA1545.1	OVOL2	MA1545.1	DDACCGTTABNYN	OVOL2	7.28e-21	3e-23	1790	14	14000	11	1.28	EPI_DAR_3hr
161	65	MA1731.1	ZNF768	MA1731.1	YBVCYBRSCCTCTCTGDG	ZNF768	7.48e-21	3.06e-23	5560	43.4	49400	38.9	1.12	EPI_DAR_3hr
162	33	MA1100.2	ASCL1	MA1100.2	VGCAGCTGCN	ASCL1	2.64e-20	1.07e-22	8390	65.5	77700	61.1	1.07	EPI_DAR_3hr
163	33	MA2002.1	Zfp335	MA2002.1	VNTCAGGCANH	Zfp335	5.17e-20	2.09e-22	8600	67.2	79900	62.8	1.07	EPI_DAR_3hr
164	36	MA0076.2	ELK4	MA0076.2	BCRCTTCCGGB	ELK4	9.58e-20	3.84e-22	327	2.55	1740	1.36	1.88	EPI_DAR_3hr
165	36	MA1933.1	ELK1::SREBF2	MA1933.1	DCCGGAAGTSRCGTGA	ELK1::SREBF2	1.05e-19	4.17e-22	2540	19.8	20800	16.4	1.21	EPI_DAR_3hr
166	33	MA1934.1	ERF::FIGLA	MA1934.1	RCCGGAARCASCTGBN	ERF::FIGLA	1.53e-19	6.08e-22	2720	21.2	22500	17.7	1.2	EPI_DAR_3hr
167	33	MA0745.2	SNAI2	MA0745.2	NBGCACCTGTMNY	SNAI2	1.68e-19	6.61e-22	9950	77.7	93900	73.8	1.05	EPI_DAR_3hr
168	66	MA1715.1	ZNF707	MA1715.1	CCCCACTCCTGGTAC	ZNF707	1.78e-19	6.96e-22	5190	40.5	46000	36.2	1.12	EPI_DAR_3hr
169	33	MA0048.2	NHLH1	MA0048.2	CGCAGCTGCK	NHLH1	2.85e-19	1.11e-21	7840	61.2	72300	56.8	1.08	EPI_DAR_3hr
170	36	MA1938.1	ERF::NHLH1	MA1938.1	VGCAGCTGCCGGAARYN	ERF::NHLH1	3.35e-19	1.3e-21	3190	24.9	26900	21.2	1.18	EPI_DAR_3hr
171	67	MA1575.1	THRB	MA1575.1	DTGACCTBRNYVAGGTCAH	THRB	6.07e-19	2.34e-21	2370	18.5	19300	15.2	1.22	EPI_DAR_3hr
172	67	MA1533.1	NR1I2	MA1533.1	DYGAACTSVDTGAACTC	NR1I2	7.69e-19	2.94e-21	7280	56.8	66700	52.4	1.08	EPI_DAR_3hr
173	33	MA1560.1	SOHLH2	MA1560.1	YGCACGTGCN	SOHLH2	6.05e-18	2.3e-20	1730	13.5	13700	10.8	1.26	EPI_DAR_3hr
174	21	MA1581.1	ZBTB6	MA1581.1	DNSCTTGAGCCNV	ZBTB6	4.2e-17	1.59e-19	10000	78.2	94900	74.6	1.05	EPI_DAR_3hr
175	68	MA0778.1	NFKB2	MA0778.1	AGGGGAWTCCCCY	NFKB2	6.17e-17	2.32e-19	2250	17.6	18500	14.5	1.21	EPI_DAR_3hr
176	33	MA1464.1	ARNT2	MA1464.1	GTCACGTGMN	ARNT2	1.27e-16	4.74e-19	2790	21.8	23500	18.5	1.18	EPI_DAR_3hr
177	45	MA0608.1	Creb3l2	MA0608.1	GCCACGTGD	Creb3l2	1.95e-16	7.24e-19	2450	19.2	20400	16	1.19	EPI_DAR_3hr
178	36	MA1992.1	Ikzf3	MA1992.1	NNRCAGGAAGTGGVN	Ikzf3	3.59e-16	1.33e-18	7410	57.9	68400	53.8	1.08	EPI_DAR_3hr
179	33	MA1621.1	Rbpjl	MA1621.1	NNVACACCTGTBNN	Rbpjl	6.16e-16	2.27e-18	8990	70.1	84400	66.3	1.06	EPI_DAR_3hr
180	53	MA1475.1	CREB3L4	MA1475.1	GRTGACGTCAYC	CREB3L4	8.4e-16	3.07e-18	6350	49.6	57900	45.5	1.09	EPI_DAR_3hr
181	31	MA0737.1	GLIS3	MA0737.1	GACCCCCCACGAAG	GLIS3	8.17e-15	2.97e-17	962	7.51	7120	5.6	1.34	EPI_DAR_3hr
182	69	MA0803.1	TBX15	MA0803.1	AGGTGTGA	TBX15	1.38e-14	4.98e-17	7110	55.5	65600	51.6	1.08	EPI_DAR_3hr
183	33	MA1652.1	ZKSCAN5	MA1652.1	NNRGGARGTGAGRR	ZKSCAN5	2.45e-14	8.8e-17	1790	14	14600	11.4	1.22	EPI_DAR_3hr
184	24	MA1930.1	CTCF	MA1930.1	CTGCAGTKCCNVCHNNYRGCCASYAGRKGGCRAKC	CTCF	5.12e-14	1.83e-16	2640	20.6	22400	17.6	1.17	EPI_DAR_3hr
185	70	MA0138.2	REST	MA0138.2	TTCAGCACCATGGACAGCDCC	REST	5.44e-14	1.94e-16	2080	16.2	17200	13.5	1.2	EPI_DAR_3hr
186	45	MA0004.1	Arnt	MA0004.1	CACGTG	Arnt	1.21e-13	4.29e-16	2020	15.8	16700	13.1	1.2	EPI_DAR_3hr
187	59	MA1485.1	FERD3L	MA1485.1	GCRMCAGCTGTYAC	FERD3L	1.44e-13	5.06e-16	2710	21.2	23100	18.2	1.16	EPI_DAR_3hr
188	36	MA0156.3	FEV	MA0156.3	VACCGGAAGTVV	FEV	5.91e-13	2.07e-15	3500	27.3	30700	24.1	1.13	EPI_DAR_3hr
189	33	MA1493.1	HES6	MA1493.1	GGCACGTGTY	HES6	6.75e-13	2.35e-15	3420	26.7	29900	23.5	1.14	EPI_DAR_3hr
190	44	MA0739.1	Hic1	MA0739.1	RTGCCAACY	Hic1	1.04e-12	3.6e-15	12000	94	117000	92.1	1.02	EPI_DAR_3hr
191	36	MA1708.1	ETV7	MA1708.1	DGSCGGAAGTR	ETV7	1.44e-12	4.95e-15	283	2.21	1640	1.29	1.72	EPI_DAR_3hr
192	33	MA0500.2	MYOG	MA0500.2	NDRCAGCTGYHN	MYOG	2.16e-12	7.42e-15	6000	46.8	55000	43.2	1.08	EPI_DAR_3hr
193	71	MA1600.1	ZNF684	MA1600.1	RYACAGTCCACCCCTTKR	ZNF684	4.14e-12	1.41e-14	3060	23.9	26600	20.9	1.14	EPI_DAR_3hr
194	34	MA0056.2	MZF1	MA0056.2	NNAATCCCCANNN	MZF1	1.58e-11	5.36e-14	11700	91.4	114000	89.3	1.02	EPI_DAR_3hr
195	49	MA1574.1	THRB	MA1574.1	RRGGTCAAAGGTCAN	THRB	2.12e-11	7.14e-14	4850	37.8	43900	34.5	1.1	EPI_DAR_3hr
196	33	MA0806.1	TBX4	MA0806.1	AGGTGTGA	TBX4	2.17e-11	7.27e-14	11100	86.4	107000	83.9	1.03	EPI_DAR_3hr
197	49	MA1147.1	NR4A2::RXRA	MA1147.1	VRGGTCRTTGACCYY	NR4A2::RXRA	5.67e-11	1.89e-13	8510	66.4	80300	63.1	1.05	EPI_DAR_3hr
198	33	MA1619.1	Ptf1A	MA1619.1	NNACAGCTGTNN	Ptf1A	1.7e-10	5.66e-13	10200	79.4	97400	76.5	1.04	EPI_DAR_3hr
199	36	MA0763.1	ETV3	MA0763.1	ACCGGAAGTR	ETV3	2.45e-10	8.1e-13	361	2.82	2340	1.84	1.53	EPI_DAR_3hr
200	69	MA1565.1	TBX18	MA1565.1	DRAGGTGTGAAR	TBX18	2.5e-10	8.22e-13	5960	46.6	55000	43.2	1.08	EPI_DAR_3hr
201	44	MA0671.1	NFIX	MA0671.1	NNTGCCAAN	NFIX	3.41e-09	1.12e-11	11400	89.2	111000	87.2	1.02	EPI_DAR_3hr
202	45	MA0822.1	HES7	MA0822.1	YGGCACGTGCCR	HES7	5.31e-09	1.73e-11	528	4.12	3800	2.98	1.38	EPI_DAR_3hr
203	33	MA0464.2	BHLHE40	MA0464.2	VKCACGTGMC	BHLHE40	5.52e-09	1.79e-11	1980	15.4	16900	13.3	1.17	EPI_DAR_3hr
204	68	MA1117.1	RELB	MA1117.1	RDATTCCCCNN	RELB	6.26e-09	2.02e-11	6990	54.5	65400	51.4	1.06	EPI_DAR_3hr
205	72	MA1556.1	RXRG	MA1556.1	RRGGTCAYGACCYY	RXRG	8.81e-09	2.83e-11	3360	26.2	29900	23.5	1.11	EPI_DAR_3hr
206	69	MA0801.1	MGA	MA0801.1	AGGTGTGA	MGA	1.14e-08	3.63e-11	6970	54.4	65300	51.4	1.06	EPI_DAR_3hr
207	33	MA0058.3	MAX	MA0058.3	AVCACGTGNY	MAX	2.6e-08	8.26e-11	1020	7.98	8180	6.43	1.24	EPI_DAR_3hr
208	33	MA0807.1	TBX5	MA0807.1	AGGTGTKA	TBX5	2.63e-08	8.33e-11	6300	49.2	58700	46.1	1.07	EPI_DAR_3hr
209	49	MA0017.2	NR2F1	MA0017.2	CARAGGTCAMVNG	NR2F1	2.67e-08	8.39e-11	3540	27.6	31800	25	1.11	EPI_DAR_3hr
210	24	MA0139.1	CTCF	MA0139.1	YGRCCASYAGRKGGCRSYR	CTCF	2.76e-08	8.66e-11	4330	33.8	39400	31	1.09	EPI_DAR_3hr
211	33	MA1559.1	SNAI3	MA1559.1	RRCAGGTGYA	SNAI3	6.89e-08	2.15e-10	7120	55.6	66900	52.6	1.06	EPI_DAR_3hr
212	73	MA1557.1	SMAD5	MA1557.1	YGTCTAGACA	SMAD5	6.95e-08	2.16e-10	6180	48.2	57600	45.3	1.07	EPI_DAR_3hr
213	55	MA0258.2	ESR2	MA0258.2	AGGTCASVNTGMCCY	ESR2	9.37e-08	2.9e-10	7700	60.1	72700	57.2	1.05	EPI_DAR_3hr
214	74	MA0863.1	MTF1	MA0863.1	TTTGCACACGGCAC	MTF1	1.05e-07	3.22e-10	1620	12.6	13700	10.7	1.17	EPI_DAR_3hr
215	72	MA1538.1	NR2F1	MA1538.1	RAGGTCANTGACCTY	NR2F1	1.2e-07	3.66e-10	3240	25.3	29000	22.8	1.11	EPI_DAR_3hr
216	31	MA1491.2	GLI3	MA1491.2	RGACCACCCACGWHGH	GLI3	1.21e-07	3.68e-10	709	5.53	5460	4.29	1.29	EPI_DAR_3hr
217	75	MA0073.1	RREB1	MA0073.1	CCCCMAAMCAMCCMCMMMCV	RREB1	2.75e-07	8.35e-10	365	2.85	2530	1.99	1.44	EPI_DAR_3hr
218	36	MA0686.1	SPDEF	MA0686.1	AMCCGGATGTR	SPDEF	4.14e-07	1.25e-09	2900	22.6	25800	20.3	1.11	EPI_DAR_3hr
219	33	MA1641.1	MYF5	MA1641.1	NVACAGCTGTBN	MYF5	5.16e-07	1.55e-09	8980	70.1	85800	67.5	1.04	EPI_DAR_3hr
220	33	MA1472.2	Bhlha15	MA1472.2	NVACAGCTGTBN	Bhlha15	1.33e-06	3.98e-09	7600	59.3	71900	56.6	1.05	EPI_DAR_3hr
221	33	MA0603.1	Arntl	MA0603.1	NGTCACGTGH	Arntl	1.37e-06	4.09e-09	10100	78.8	97400	76.6	1.03	EPI_DAR_3hr
222	53	MA0638.1	CREB3	MA0638.1	VTGCCACGTCAYCR	CREB3	2.19e-06	6.49e-09	1800	14.1	15600	12.2	1.15	EPI_DAR_3hr
223	76	MA0130.1	ZNF354C	MA0130.1	MTCCAC	ZNF354C	5.36e-06	1.58e-08	11400	89.1	111000	87.4	1.02	EPI_DAR_3hr
224	77	MA1999.1	Prdm5	MA1999.1	CBGTTCTCCATCTNN	Prdm5	1.7e-05	4.98e-08	10600	82.8	103000	80.9	1.02	EPI_DAR_3hr
225	36	MA0760.1	ERF	MA0760.1	ACCGGAAGTR	ERF	2.18e-05	6.37e-08	4190	32.7	38600	30.4	1.08	EPI_DAR_3hr
226	33	MA0825.1	MNT	MA0825.1	RVCACGTGMH	MNT	2.72e-05	7.91e-08	1710	13.3	14900	11.7	1.14	EPI_DAR_3hr
227	53	MA0839.1	CREB3L1	MA0839.1	VTGCCACGTCAYCA	CREB3L1	3.85e-05	1.12e-07	1710	13.4	14900	11.7	1.14	EPI_DAR_3hr
228	78	MA1529.1 (NHLH2)	STREME-11	11-CAGGGAGGCAGCTS	11-CAGGGAGGCAGCTS	NHLH2	4.37e-05	1.26e-07	1140	8.91	9630	7.57	1.18	EPI_DAR_3hr
229	53	MA0636.1	BHLHE41	MA0636.1	RTCACGTGAC	BHLHE41	7.77e-05	2.23e-07	1780	13.9	15600	12.2	1.13	EPI_DAR_3hr
230	53	MA0604.1	Atf1	MA0604.1	RTGACGTA	Atf1	9.81e-05	2.81e-07	1490	11.6	12900	10.1	1.15	EPI_DAR_3hr
231	43	MA0779.1	PAX1	MA0779.1	CGTCACGCWTGAVTGMM	PAX1	0.000156	4.44e-07	980	7.65	8210	6.45	1.19	EPI_DAR_3hr
232	33	MA0521.2	Tcf12	MA0521.2	NNACAGCTGTNN	Tcf12	0.000276	7.82e-07	6150	48	58100	45.7	1.05	EPI_DAR_3hr
233	45	MA0622.1	Mlxip	MA0622.1	BCACGTGK	Mlxip	0.000291	8.21e-07	449	3.5	3460	2.72	1.29	EPI_DAR_3hr
234	79	MA1651.1	ZFP42	MA1651.1	NNNHCAARATGGCTGCCNBNN	ZFP42	0.000324	9.1e-07	391	3.05	2950	2.32	1.32	EPI_DAR_3hr
235	80	MA1468.1	ATOH7	MA1468.1	AVCATATGBY	ATOH7	0.000401	1.12e-06	10600	82.6	103000	80.8	1.02	EPI_DAR_3hr
236	53	MA0844.1	XBP1	MA0844.1	WDKGMCACGTCATC	XBP1	0.000432	1.21e-06	1680	13.1	14800	11.7	1.13	EPI_DAR_3hr
237	42	MA0609.2	CREM	MA0609.2	NNDGTGACGTCACHNN	CREM	0.000709	1.97e-06	8110	63.3	77800	61.2	1.04	EPI_DAR_3hr
238	36	MA1931.1	ELK1::HOXA1	MA1931.1	ACCGGAAGTAATTA	ELK1::HOXA1	0.00157	4.33e-06	43	0.34	178	0.14	2.44	EPI_DAR_3hr
239	53	MA1969.1	THRA	MA1969.1	NYTGTGTCCTCABRTGACCTYWBB	THRA	0.00187	5.16e-06	2080	16.3	18700	14.7	1.1	EPI_DAR_3hr
240	33	MA1620.1	Ptf1A	MA1620.1	NVACACCTGTNN	Ptf1A	0.00205	5.63e-06	7010	54.7	66900	52.6	1.04	EPI_DAR_3hr
241	81	MA1554.1	RFX7	MA1554.1	CGTTGCYAY	RFX7	0.00241	6.59e-06	5970	46.6	56600	44.5	1.05	EPI_DAR_3hr
242	44	MA0119.1	NFIC::TLX1	MA0119.1	TGGCASSRWGCCAA	NFIC::TLX1	0.00542	1.47e-05	834	6.51	7060	5.55	1.17	EPI_DAR_3hr
243	42	MA0862.1	GMEB2	MA0862.1	TTACGTAA	GMEB2	0.00561	1.52e-05	1020	7.95	8770	6.89	1.15	EPI_DAR_3hr
244	36	MA0098.3	ETS1	MA0098.3	ACCGGAARTR	ETS1	0.00579	1.56e-05	6200	48.4	58900	46.3	1.04	EPI_DAR_3hr
245	36	MA1957.1	HOXB2::ELK1	MA1957.1	RCCGGAAGTMRTTA	HOXB2::ELK1	0.00773	2.08e-05	18	0.14	45	0.04	4.1	EPI_DAR_3hr
246	33	MA0820.1	FIGLA	MA0820.1	WMCACCTGKW	FIGLA	0.00871	2.33e-05	12100	94.3	119000	93.3	1.01	EPI_DAR_3hr
247	10	MA0657.1	KLF13	MA0657.1	RTGMCACGCCCCTTTTTG	KLF13	0.00883	2.35e-05	1010	7.86	8700	6.84	1.15	EPI_DAR_3hr
248	82	MA1716.1	ZNF76	MA1716.1	NNTWCCCAYAATGCAHYGCGC	ZNF76	0.0102	2.72e-05	536	4.18	4380	3.44	1.22	EPI_DAR_3hr
250	36	MA0645.1	ETV6	MA0645.1	MSCGGAAGTR	ETV6	0.0104	2.73e-05	8020	62.6	77200	60.7	1.03	EPI_DAR_3hr
249	72	MA1146.1	NR1H4::RXRA	MA1146.1	GAGKTCATTGACCYB	NR1H4::RXRA	0.0104	2.73e-05	9640	75.3	93500	73.6	1.02	EPI_DAR_3hr
251	36	MA1484.1	ETS2	MA1484.1	DACCGGAAGY	ETS2	0.0123	3.24e-05	951	7.42	8200	6.44	1.15	EPI_DAR_3hr
252	44	MA1527.1	NFIC	MA1527.1	NTTGGCDNNRTGCCARN	NFIC	0.0134	3.5e-05	475	3.71	3840	3.02	1.23	EPI_DAR_3hr
253	83	MA0502.2	NFYB	MA0502.2	CYCATTGGCCVV	NFYB	0.019	4.95e-05	8290	64.7	80000	62.9	1.03	EPI_DAR_3hr
254	84	MA1491.2 (GLI3)	STREME-10	10-ACACACACGA	10-ACACACACGA	GLI3	0.0317	8.23e-05	348	2.72	2740	2.16	1.26	EPI_DAR_3hr
255	69	MA1567.2	Tbx6	MA1567.2	NRGGTGTGAANN	Tbx6	0.0322	8.32e-05	5900	46	56200	44.2	1.04	EPI_DAR_3hr
256	53	MA1466.1	ATF6	MA1466.1	TGRTGACGTGGCAN	ATF6	0.041	0.000105	434	3.39	3520	2.77	1.23	EPI_DAR_3hr
257	53	MA0663.1	MLX	MA0663.1	RTCACGTGAT	MLX	0.047	0.00012	3580	27.9	33500	26.4	1.06	EPI_DAR_3hr
258	36	MA0475.2	FLI1	MA0475.2	ACCGGAARTR	FLI1	0.047	0.00012	1410	11	12600	9.92	1.11	EPI_DAR_3hr
259	85	MA1531.1	NR1D1	MA1531.1	RGGTYAGTRGGTCAN	NR1D1	0.0486	0.000124	1960	15.3	17800	14	1.09	EPI_DAR_3hr
13	86	MA1125.1 (ZNF384)	MEME-2	TTTTTTTTTTTTTTT	TTTTTTTTTTTTTTT	ZNF384	11.7	0.903	129	1.01	1440	1.13	0.899	EPI_DAR_3hr

ER_rat <- 1.25
# mrc_type <- "EAR_open"
EPI_DAR_3hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  # geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_col(aes(x=log10Evalue))+
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("EPI_DAR_3hr_combo response peaks(200bp) Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

EPI_DAR_3hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  # geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*3), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./3,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("EPI DAR 3 hour response peaks(200bp) Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

EPI_DAR_24hr data

EPI_DAR_24hr_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_24_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
EPI_DAR_24hr_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_24_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
EPI_DAR_24hr_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_24_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
EPI_DAR_24hr_sea_all <- rbind(EPI_DAR_24hr_sea_disc, EPI_DAR_24hr_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

EPI_DAR_24hr_combo <- EPI_DAR_24hr_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., EPI_DAR_24hr_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="EPI_DAR_24hr")

EPI_DAR_24hr_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp EPI_DAR_24hr") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp EPI_DAR_24hr
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA1134.1 (FOS::JUNB)	STREME-1	1-DATGASTCATH	DATGASTCATH	FOS::JUNB	0	0	8380	14	4880	6.09	2.3	EPI_DAR_24hr
2	1	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	0	0	11100	18.5	7580	9.45	1.96	EPI_DAR_24hr
3	1	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	0	0	9740	16.3	6260	7.82	2.08	EPI_DAR_24hr
4	1	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	0	0	10200	17	6700	8.36	2.03	EPI_DAR_24hr
5	1	MA0655.1 (JDP2)	STREME-6	6-ATGACTCA	ATGACTCA	JDP2	0	0	9900	16.5	6480	8.09	2.05	EPI_DAR_24hr
6	1	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	0	0	10300	17.3	6940	8.66	2	EPI_DAR_24hr
7	1	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	0	0	10400	17.4	7000	8.74	1.99	EPI_DAR_24hr
8	1	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	0	0	9510	15.9	6120	7.64	2.08	EPI_DAR_24hr
9	1	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	0	0	10500	17.5	7110	8.87	1.98	EPI_DAR_24hr
10	1	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	0	0	10500	17.6	7170	8.95	1.97	EPI_DAR_24hr
11	1	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	0	0	10800	18	7400	9.23	1.95	EPI_DAR_24hr
12	1	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	0	0	7780	13	4520	5.64	2.31	EPI_DAR_24hr
13	1	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	0	0	10500	17.5	7120	8.89	1.97	EPI_DAR_24hr
14	1	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	0	0	9760	16.3	6420	8.02	2.04	EPI_DAR_24hr
15	1	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	0	0	11500	19.2	8160	10.2	1.88	EPI_DAR_24hr
16	1	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	0	0	11000	18.4	7800	9.73	1.89	EPI_DAR_24hr
17	1	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	0	0	11200	18.7	8000	9.98	1.88	EPI_DAR_24hr
18	1	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	0	0	11000	18.4	7860	9.8	1.88	EPI_DAR_24hr
19	1	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	0	0	8710	14.6	5570	6.95	2.09	EPI_DAR_24hr
20	1	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	0	0	7920	13.2	4830	6.02	2.2	EPI_DAR_24hr
21	1	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	0	0	11100	18.5	7950	9.92	1.87	EPI_DAR_24hr
22	1	MA0476.1 (FOS)	MEME-2	ATGASTCABHH	ATGASTCABHH	FOS	0	0	6700	11.2	3730	4.66	2.4	EPI_DAR_24hr
23	1	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	0	0	6260	10.5	3400	4.25	2.46	EPI_DAR_24hr
24	1	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	0	0	7840	13.1	4920	6.14	2.13	EPI_DAR_24hr
25	1	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	0	0	12300	20.6	9680	12.1	1.71	EPI_DAR_24hr
26	1	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	0	0	6640	11.1	3930	4.9	2.26	EPI_DAR_24hr
27	1	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	0	0	5550	9.28	2960	3.69	2.51	EPI_DAR_24hr
28	1	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	0	0	11800	19.8	9160	11.4	1.73	EPI_DAR_24hr
29	1	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	0	0	8050	13.4	5340	6.66	2.02	EPI_DAR_24hr
30	1	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	6.41e-201	1.04e-202	14400	24	13900	17.4	1.38	EPI_DAR_24hr
31	1	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	2.12e-189	3.33e-191	20800	34.7	21900	27.3	1.27	EPI_DAR_24hr
32	1	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	6.28e-146	9.58e-148	23500	39.3	26100	32.6	1.21	EPI_DAR_24hr
33	1	MA0150.2	Nfe2l2	MA0150.2	CASNATGACTCAGCA	Nfe2l2	1.56e-123	2.31e-125	14100	23.6	14700	18.4	1.29	EPI_DAR_24hr
34	2	MA0498.2 (MEIS1)	STREME-2	2-YTGWCAR	YTGWCAR	MEIS1	1.29e-108	1.86e-110	54700	91.3	70200	87.6	1.04	EPI_DAR_24hr
35	1	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	3.5e-104	4.87e-106	6450	10.8	5920	7.39	1.46	EPI_DAR_24hr
36	3	MA0720.1	Shox2	MA0720.1	YYAATTAR	Shox2	3.41e-90	4.63e-92	52900	88.3	67800	84.6	1.04	EPI_DAR_24hr
37	3	MA0722.1	VAX1	MA0722.1	YTAATTAH	VAX1	8.43e-86	1.11e-87	52700	88.1	67600	84.3	1.04	EPI_DAR_24hr
38	3	MA0674.1	NKX6-1	MA0674.1	NTMATTAA	NKX6-1	6.19e-84	7.95e-86	54800	91.6	70800	88.4	1.04	EPI_DAR_24hr
39	3	MA0725.1	VSX1	MA0725.1	YTAATTAN	VSX1	5.52e-83	6.91e-85	53400	89.3	68700	85.8	1.04	EPI_DAR_24hr
40	3	MA0630.1	SHOX	MA0630.1	HTAATTRR	SHOX	5.92e-81	7.23e-83	52300	87.4	67100	83.8	1.04	EPI_DAR_24hr
41	3	MA0726.1	VSX2	MA0726.1	CTAATTAN	VSX2	1.55e-75	1.84e-77	49700	83	63400	79	1.05	EPI_DAR_24hr
42	3	MA0027.2	EN1	MA0027.2	SYAATTAV	EN1	8.19e-75	9.52e-77	50500	84.4	64600	80.5	1.05	EPI_DAR_24hr
43	3	MA0704.1	Lhx4	MA0704.1	YTAATTAR	Lhx4	1.27e-74	1.44e-76	46000	76.8	58100	72.4	1.06	EPI_DAR_24hr
44	4	MA0676.1	Nr2e1	MA0676.1	AAAAGTCAA	Nr2e1	3.89e-73	4.31e-75	47300	79.1	60000	74.9	1.06	EPI_DAR_24hr
45	3	MA0886.1	EMX2	MA0886.1	VBTAATTARB	EMX2	4.52e-73	4.9e-75	42300	70.6	52900	66	1.07	EPI_DAR_24hr
46	5	MA0084.1	SRY	MA0084.1	NWWAACAAT	SRY	7.77e-73	8.24e-75	54700	91.3	70800	88.3	1.03	EPI_DAR_24hr
47	3	MA0902.2	HOXB2	MA0902.2	SYAATTAS	HOXB2	1.17e-72	1.21e-74	39400	65.8	48900	61	1.08	EPI_DAR_24hr
48	3	MA0675.1	NKX6-2	MA0675.1	NYMATTAA	NKX6-2	1.52e-70	1.55e-72	49400	82.6	63100	78.8	1.05	EPI_DAR_24hr
49	3	MA0716.1	PRRX1	MA0716.1	YYAATTAR	PRRX1	3.78e-70	3.76e-72	52200	87.1	67100	83.7	1.04	EPI_DAR_24hr
50	6	3-GAGTTA	STREME-3	3-GAGTTA	GAGTTA	GAGTTA	7.51e-70	7.33e-72	57900	96.7	75900	94.7	1.02	EPI_DAR_24hr
51	1	MA1113.2	PBX2	MA1113.2	NHCATAAATCAHN	PBX2	1.31e-69	1.26e-71	48900	81.7	62400	77.8	1.05	EPI_DAR_24hr
52	3	MA0125.1	Nobox	MA0125.1	TAATTRSY	Nobox	7.75e-69	7.27e-71	52100	87	67000	83.6	1.04	EPI_DAR_24hr
53	3	MA0644.2	ESX1	MA0644.2	YYAATTAN	ESX1	1.54e-67	1.42e-69	46400	77.6	58900	73.4	1.06	EPI_DAR_24hr
54	3	MA0879.2	DLX1	MA0879.2	VYAATTAN	DLX1	2.69e-67	2.43e-69	50800	84.9	65200	81.3	1.04	EPI_DAR_24hr
55	7	10-AATAAG	STREME-10	10-AATAAG	10-AATAAG	AATAAG	3.32e-67	2.95e-69	49800	83.2	63700	79.4	1.05	EPI_DAR_24hr
56	3	MA0718.1	RAX	MA0718.1	RYYAATTARH	RAX	4.49e-67	3.91e-69	46000	76.8	58200	72.6	1.06	EPI_DAR_24hr
57	8	MA1480.1	DPRX	MA1480.1	AGATAATCCN	DPRX	9.58e-66	8.2e-68	51500	86	66200	82.5	1.04	EPI_DAR_24hr
58	3	MA0721.1	UNCX	MA0721.1	YYAATTAV	UNCX	2.55e-65	2.14e-67	51300	85.7	65900	82.2	1.04	EPI_DAR_24hr
59	3	MA0717.1	RAX2	MA0717.1	YYAATTAV	RAX2	5.83e-65	4.82e-67	52200	87.2	67300	83.9	1.04	EPI_DAR_24hr
60	3	MA0882.1	DLX6	MA0882.1	VYAATTAN	DLX6	1.3e-64	1.05e-66	47000	78.5	59700	74.5	1.05	EPI_DAR_24hr
61	3	MA0881.1	Dlx4	MA0881.1	VYAATTAN	Dlx4	8e-63	6.4e-65	51600	86.1	66400	82.8	1.04	EPI_DAR_24hr
62	1	MA1639.1	MEIS1	MA1639.1	NHCATMAATCAHN	MEIS1	9.09e-62	7.16e-64	50200	83.9	64400	80.4	1.04	EPI_DAR_24hr
63	9	MA1963.1	SATB1	MA1963.1	WWDCTAATAAHWW	SATB1	9.38e-62	7.27e-64	43300	72.4	54700	68.2	1.06	EPI_DAR_24hr
64	3	MA1476.2	Dlx5	MA1476.2	NDGCAATTAGNN	Dlx5	1.16e-61	8.86e-64	53700	89.8	69600	86.8	1.03	EPI_DAR_24hr
65	3	MA0793.1	POU6F2	MA0793.1	ASCTMATTAW	POU6F2	1.21e-61	9.06e-64	46200	77.2	58700	73.2	1.05	EPI_DAR_24hr
66	1	MA1640.1	MEIS2	MA1640.1	NNATGATTTATGDNH	MEIS2	1.25e-61	9.23e-64	48000	80.2	61300	76.4	1.05	EPI_DAR_24hr
67	3	MA1502.1	HOXB8	MA1502.1	GYMATTAM	HOXB8	2.47e-61	1.8e-63	36700	61.4	45600	56.9	1.08	EPI_DAR_24hr
68	3	MA0634.1	ALX3	MA0634.1	YYYAATTANV	ALX3	2.87e-60	2.06e-62	56200	93.9	73400	91.5	1.03	EPI_DAR_24hr
69	3	MA0068.2	PAX4	MA0068.2	CTAATTAG	PAX4	8.14e-60	5.76e-62	53300	89.1	69000	86.1	1.03	EPI_DAR_24hr
70	10	MA0035.4	GATA1	MA0035.4	NHCTAATCTDH	GATA1	1.44e-59	1e-61	52100	87.1	67300	83.9	1.04	EPI_DAR_24hr
71	3	MA0706.1	MEOX2	MA0706.1	DSTAATTAWN	MEOX2	2.42e-59	1.66e-61	51800	86.6	66800	83.4	1.04	EPI_DAR_24hr
72	3	MA0628.1	POU6F1	MA0628.1	AYTAATTART	POU6F1	4.21e-59	2.85e-61	48300	80.8	61800	77.1	1.05	EPI_DAR_24hr
73	3	MA0880.1	Dlx3	MA0880.1	NYAATTAN	Dlx3	1.79e-58	1.2e-60	53200	88.8	68800	85.9	1.03	EPI_DAR_24hr
74	3	MA0910.2	HOXD8	MA0910.2	GYMATTAM	HOXD8	5.33e-58	3.52e-60	35100	58.6	43500	54.2	1.08	EPI_DAR_24hr
75	10	MA0036.3	GATA2	MA0036.3	NBCTTATCTNH	GATA2	3.59e-57	2.33e-59	53800	90	69900	87.2	1.03	EPI_DAR_24hr
76	3	MA1481.1	DRGX	MA1481.1	YYAATTAN	DRGX	3.81e-57	2.45e-59	44400	74.1	56300	70.2	1.06	EPI_DAR_24hr
77	3	MA0885.2	Dlx2	MA0885.2	NDGCAATTAGNN	Dlx2	9.96e-57	6.31e-59	53000	88.6	68600	85.6	1.03	EPI_DAR_24hr
78	3	MA0708.2	MSX2	MA0708.2	SCAATTAV	MSX2	2.6e-56	1.62e-58	49300	82.4	63300	78.9	1.04	EPI_DAR_24hr
79	11	MA0899.1	HOXA10	MA0899.1	DGYMATAAAAH	HOXA10	4.85e-56	2.99e-58	53000	88.5	68600	85.5	1.03	EPI_DAR_24hr
80	11	MA0650.3	Hoxa13	MA0650.3	NNCCAATAAAAN	Hoxa13	6.22e-56	3.79e-58	51900	86.7	67000	83.6	1.04	EPI_DAR_24hr
81	3	MA0887.1	EVX1	MA0887.1	VVTAATTABS	EVX1	9.03e-55	5.44e-57	52500	87.7	67900	84.8	1.04	EPI_DAR_24hr
82	10	MA1104.2	GATA6	MA1104.2	HWWTCTTATCTNH	GATA6	9.29e-55	5.53e-57	54900	91.7	71400	89.1	1.03	EPI_DAR_24hr
83	3	MA0648.1	GSC	MA0648.1	VYTAATCCSY	GSC	1.11e-54	6.52e-57	47400	79.3	60600	75.7	1.05	EPI_DAR_24hr
84	12	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	2.3e-54	1.34e-56	50100	83.7	64400	80.4	1.04	EPI_DAR_24hr
85	3	MA0903.1	HOXB3	MA0903.1	NNYMATTARN	HOXB3	2.38e-54	1.37e-56	53700	89.7	69700	86.9	1.03	EPI_DAR_24hr
86	3	MA0890.1	GBX2	MA0890.1	RSYAATTARN	GBX2	3.23e-54	1.83e-56	47200	78.9	60400	75.3	1.05	EPI_DAR_24hr
87	3	MA0661.1	MEOX1	MA0661.1	VSTAATTAHC	MEOX1	2.49e-53	1.4e-55	48900	81.6	62700	78.2	1.04	EPI_DAR_24hr
88	3	MA0713.1	PHOX2A	MA0713.1	TAATYYAATTA	PHOX2A	5.49e-53	3.05e-55	43600	72.9	55300	69	1.06	EPI_DAR_24hr
89	3	MA0710.1	NOTO	MA0710.1	NYTAATTAVN	NOTO	8.67e-53	4.75e-55	42300	70.7	53500	66.8	1.06	EPI_DAR_24hr
90	11	MA0901.2	HOXB13	MA0901.2	WDCCAATAAAAWWW	HOXB13	1.69e-52	9.18e-55	45200	75.5	57500	71.7	1.05	EPI_DAR_24hr
91	3	MA1505.1	HOXC8	MA1505.1	KTAATTAM	HOXC8	4.18e-52	2.24e-54	39300	65.7	49400	61.6	1.07	EPI_DAR_24hr
92	3	MA0707.2	MNX1	MA0707.2	VYRATTAK	MNX1	4.29e-52	2.27e-54	31000	51.8	38200	47.6	1.09	EPI_DAR_24hr
93	3	MA0889.1	GBX1	MA0889.1	VCYAATTASY	GBX1	5.73e-52	3e-54	44900	75.1	57200	71.3	1.05	EPI_DAR_24hr
94	3	MA0723.2	VAX2	MA0723.2	BYAATTAV	VAX2	1.2e-51	6.24e-54	43100	72	54600	68.1	1.06	EPI_DAR_24hr
95	13	MA0635.1	BARHL2	MA0635.1	VHTAAAYGRT	BARHL2	1.76e-51	9.03e-54	53300	89	69100	86.2	1.03	EPI_DAR_24hr
96	3	MA0658.1	LHX6	MA0658.1	RCTAATTARY	LHX6	3.04e-51	1.55e-53	40500	67.7	51100	63.7	1.06	EPI_DAR_24hr
97	14	MA0786.1	POU3F1	MA0786.1	WTATGCWAATKW	POU3F1	1.09e-50	5.47e-53	49000	81.9	63000	78.6	1.04	EPI_DAR_24hr
98	12	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	1.38e-50	6.87e-53	54400	91	70900	88.4	1.03	EPI_DAR_24hr
99	3	MA1471.1	BARX2	MA1471.1	NWWAAYMATTAN	BARX2	1.65e-50	8.13e-53	48900	81.7	62800	78.4	1.04	EPI_DAR_24hr
100	11	MA0465.2	CDX2	MA0465.2	NDGCAATAAAWN	CDX2	1.73e-50	8.43e-53	53800	89.9	69900	87.3	1.03	EPI_DAR_24hr
101	3	MA0876.1	BSX	MA0876.1	SYVATTAV	BSX	5.39e-50	2.6e-52	49900	83.4	64300	80.2	1.04	EPI_DAR_24hr
102	12	MA0041.2	FOXD3	MA0041.2	WAWGHAAATAAACARY	FOXD3	7.39e-50	3.54e-52	49900	83.4	64300	80.3	1.04	EPI_DAR_24hr
103	10	MA1970.1	TRPS1	MA1970.1	NHTCTTATCTNH	TRPS1	8.34e-50	3.95e-52	46900	78.4	60100	75	1.05	EPI_DAR_24hr
104	15	MA0790.1	POU4F1	MA0790.1	ATGMATAATTAATG	POU4F1	8.96e-50	4.2e-52	43900	73.4	55900	69.7	1.05	EPI_DAR_24hr
105	16	4-TTTSAAA	STREME-4	4-TTTSAAA	TTTSAAA	TTTSAAA	2.3e-49	1.07e-51	53900	90	70000	87.4	1.03	EPI_DAR_24hr
106	3	MA0680.2	Pax7	MA0680.2	DWTAATCAATTAWNH	Pax7	3.23e-49	1.49e-51	39500	66	49800	62.1	1.06	EPI_DAR_24hr
107	3	MA0666.2	MSX1	MA0666.2	SCAATTAR	MSX1	3.81e-49	1.74e-51	41000	68.5	51800	64.6	1.06	EPI_DAR_24hr
108	3	MA1549.1	POU6F1	MA1549.1	RTAATGAGVN	POU6F1	2.26e-48	1.01e-50	38900	64.9	48900	61	1.06	EPI_DAR_24hr
109	3	MA0709.1	Msx3	MA0709.1	SCAATTAN	Msx3	2.26e-48	1.01e-50	47600	79.6	61100	76.2	1.04	EPI_DAR_24hr
110	14	MA0792.1	POU5F1B	MA0792.1	TATGCWAAT	POU5F1B	2.42e-48	1.07e-50	50500	84.4	65200	81.4	1.04	EPI_DAR_24hr
111	14	MA0785.1	POU2F1	MA0785.1	AWTATGCWAATK	POU2F1	2.77e-48	1.22e-50	49700	83.1	64000	79.9	1.04	EPI_DAR_24hr
112	17	MA0052.4	MEF2A	MA0052.4	DDCTAAAAATAGMHH	MEF2A	3.84e-48	1.67e-50	46100	77.1	59000	73.6	1.05	EPI_DAR_24hr
113	3	MA0699.1	LBX2	MA0699.1	NCYAATTARN	LBX2	6.88e-48	2.97e-50	53200	89	69200	86.3	1.03	EPI_DAR_24hr
114	3	MA1498.2	HOXA7	MA1498.2	SYMATTAV	HOXA7	1.26e-47	5.4e-50	46800	78.2	60000	74.8	1.05	EPI_DAR_24hr
115	18	MA0602.1	Arid5a	MA0602.1	SYAATATTGVDANH	Arid5a	1.32e-47	5.61e-50	49300	82.3	63400	79.1	1.04	EPI_DAR_24hr
116	3	MA0158.2	HOXA5	MA0158.2	GYMATTAS	HOXA5	4.85e-47	2.04e-49	25100	42	30500	38.1	1.1	EPI_DAR_24hr
117	3	MA0700.2	LHX2	MA0700.2	DDCCAATTADN	LHX2	1.05e-46	4.38e-49	48400	80.9	62200	77.6	1.04	EPI_DAR_24hr
118	3	MA0654.1	ISX	MA0654.1	YYAATTAR	ISX	1.22e-46	5.02e-49	37800	63.1	47500	59.2	1.07	EPI_DAR_24hr
119	3	MA0701.2	LHX9	MA0701.2	CYAATTAR	LHX9	1.37e-46	5.63e-49	29300	48.9	36000	44.9	1.09	EPI_DAR_24hr
120	3	MA0662.1	MIXL1	MA0662.1	NBYAATTAVN	MIXL1	1.45e-46	5.89e-49	48500	81.1	62400	77.8	1.04	EPI_DAR_24hr
121	15	MA0791.1	POU4F3	MA0791.1	RTGMATWATTAATGAR	POU4F3	3.13e-46	1.26e-48	40800	68.1	51600	64.3	1.06	EPI_DAR_24hr
122	14	MA0142.1	Pou5f1::Sox2	MA0142.1	CWTTGTYATGCAAAT	Pou5f1::Sox2	4.35e-46	1.74e-48	47400	79.2	60800	75.8	1.04	EPI_DAR_24hr
123	3	MA1519.1	LHX5	MA1519.1	STAATTAV	LHX5	5.33e-46	2.11e-48	27000	45.1	33000	41.2	1.1	EPI_DAR_24hr
124	14	MA0788.1	POU3F3	MA0788.1	WWTATGCWAATTW	POU3F3	8.36e-46	3.29e-48	46000	76.8	58800	73.4	1.05	EPI_DAR_24hr
125	3	MA0894.1	HESX1	MA0894.1	GHTAATTRRH	HESX1	1.81e-45	7.06e-48	39700	66.3	50100	62.5	1.06	EPI_DAR_24hr
126	3	MA0711.1	OTX1	MA0711.1	HTAATCCS	OTX1	4.55e-45	1.76e-47	53200	88.9	69200	86.4	1.03	EPI_DAR_24hr
127	12	MA0032.2	FOXC1	MA0032.2	WAWGTAAAYAW	FOXC1	5.74e-45	2.21e-47	50100	83.7	64700	80.7	1.04	EPI_DAR_24hr
128	3	MA1495.1	HOXA1	MA1495.1	STAATTAS	HOXA1	5.85e-45	2.23e-47	26300	43.9	32100	40	1.1	EPI_DAR_24hr
129	12	MA0047.3	FOXA2	MA0047.3	RWGTAAACANN	FOXA2	7.17e-45	2.71e-47	53700	89.7	69900	87.2	1.03	EPI_DAR_24hr
130	5	MA1152.1	SOX15	MA1152.1	CYWTTGTTHW	SOX15	1.97e-44	7.39e-47	53600	89.5	69800	87	1.03	EPI_DAR_24hr
131	3	MA1530.1	NKX6-3	MA1530.1	VYCATTAWW	NKX6-3	2.9e-44	1.08e-46	33700	56.3	42000	52.4	1.07	EPI_DAR_24hr
132	19	MA0769.2	TCF7	MA0769.2	NNCTTTGAWVT	TCF7	3.2e-44	1.18e-46	54100	90.4	70600	88	1.03	EPI_DAR_24hr
133	20	MA0495.3	MAFF	MA0495.3	DWGTCAGCATTTTWHN	MAFF	4.19e-44	1.54e-46	40100	67.1	50800	63.4	1.06	EPI_DAR_24hr
134	3	MA0891.1	GSC2	MA0891.1	NYTAATCCBH	GSC2	1.64e-43	5.97e-46	51700	86.4	67100	83.7	1.03	EPI_DAR_24hr
135	3	MA0888.1	EVX2	MA0888.1	VVTAATTAVB	EVX2	1.83e-43	6.63e-46	48900	81.6	63000	78.6	1.04	EPI_DAR_24hr
136	10	MA0037.4	Gata3	MA0037.4	NHTCTTATCTNH	Gata3	1.91e-43	6.84e-46	50200	83.9	64900	81	1.04	EPI_DAR_24hr
137	3	MA1608.1	Isl1	MA1608.1	NNCCATTAGNN	Isl1	2.79e-43	9.93e-46	52900	88.3	68700	85.7	1.03	EPI_DAR_24hr
138	12	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	1.04e-42	3.69e-45	52400	87.6	68100	85	1.03	EPI_DAR_24hr
139	8	MA0714.1	PITX3	MA0714.1	NYTAATCCC	PITX3	1.57e-42	5.52e-45	56900	95	74700	93.2	1.02	EPI_DAR_24hr
140	12	MA1607.1	Foxl2	MA1607.1	DDWATGTAAACANN	Foxl2	1.67e-42	5.81e-45	53800	89.9	70100	87.5	1.03	EPI_DAR_24hr
141	3	MA0705.1	Lhx8	MA0705.1	CTAATTAV	Lhx8	7.19e-42	2.49e-44	32800	54.8	40900	51	1.07	EPI_DAR_24hr
142	5	MA0077.1	SOX9	MA0077.1	CYATTGTTY	SOX9	7.59e-42	2.61e-44	50100	83.8	64800	80.9	1.04	EPI_DAR_24hr
143	12	MA0148.4	FOXA1	MA0148.4	WWGTAAACATNN	FOXA1	8.48e-42	2.89e-44	52400	87.5	68100	84.9	1.03	EPI_DAR_24hr
144	3	MA0892.1	GSX1	MA0892.1	NCYMATTAVN	GSX1	1.61e-41	5.44e-44	55000	92	72000	89.8	1.02	EPI_DAR_24hr
145	8	MA0712.2	OTX2	MA0712.2	NDRGGATTARNN	OTX2	1.01e-40	3.41e-43	54100	90.3	70500	88	1.03	EPI_DAR_24hr
146	3	MA1518.2	Lhx1	MA1518.2	NNNTGCTAATTAGCANNN	Lhx1	2.46e-40	8.22e-43	47800	79.8	61500	76.8	1.04	EPI_DAR_24hr
147	3	MA0895.1	HMBOX1	MA0895.1	MYTAGTTAMS	HMBOX1	4.24e-40	1.41e-42	55700	93.1	73000	91	1.02	EPI_DAR_24hr
148	11	MA0905.1	HOXC10	MA0905.1	GTCRTAAAAH	HOXC10	4.53e-40	1.49e-42	43900	73.4	56100	70	1.05	EPI_DAR_24hr
149	21	MA1657.1	ZNF652	MA1657.1	BAAAGRGTTAAN	ZNF652	4.8e-40	1.57e-42	48700	81.4	62900	78.5	1.04	EPI_DAR_24hr
150	3	MA0904.2	HOXB5	MA0904.2	STAATTAS	HOXB5	1.03e-39	3.34e-42	25000	41.8	30600	38.2	1.09	EPI_DAR_24hr
151	13	MA1978.1	ZNF354A	MA1978.1	HWAADWATAAATGRAYWAWTT	ZNF354A	1.19e-39	3.84e-42	51500	86	66800	83.4	1.03	EPI_DAR_24hr
152	12	MA0481.3	FOXP1	MA0481.3	NDGTAAACANH	FOXP1	2.6e-39	8.36e-42	53600	89.6	69900	87.2	1.03	EPI_DAR_24hr
153	22	MA0679.2	ONECUT1	MA0679.2	WAAAAATCAATAAWWN	ONECUT1	3.35e-39	1.07e-41	37600	62.9	47500	59.3	1.06	EPI_DAR_24hr
154	12	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	6.63e-39	2.1e-41	51500	86.1	66900	83.5	1.03	EPI_DAR_24hr
155	12	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	1.99e-38	6.28e-41	52000	87	67700	84.4	1.03	EPI_DAR_24hr
156	3	MA1497.1	HOXA6	MA1497.1	BGYMATTANN	HOXA6	2.7e-38	8.44e-41	46700	78	60000	74.9	1.04	EPI_DAR_24hr
157	14	MA0789.1	POU3F4	MA0789.1	TATGCWAAT	POU3F4	7.84e-38	2.44e-40	43300	72.4	55400	69.1	1.05	EPI_DAR_24hr
158	14	MA1115.1	POU5F1	MA1115.1	WHATGCAAATN	POU5F1	8.47e-38	2.62e-40	48000	80.2	61900	77.3	1.04	EPI_DAR_24hr
159	3	MA0875.1	BARX1	MA0875.1	VCMATTAV	BARX1	1.49e-37	4.59e-40	45400	75.9	58300	72.8	1.04	EPI_DAR_24hr
160	23	MA0809.2	TEAD4	MA0809.2	NNACATTCCARN	TEAD4	2.03e-37	6.2e-40	51100	85.4	66400	82.8	1.03	EPI_DAR_24hr
161	15	MA0153.2	HNF1B	MA0153.2	GTTAATNATTAAY	HNF1B	8.05e-37	2.44e-39	24400	40.8	29900	37.3	1.09	EPI_DAR_24hr
162	5	MA0868.2	SOX8	MA0868.2	MGAACAATRG	SOX8	1.04e-35	3.13e-38	49200	82.1	63600	79.4	1.03	EPI_DAR_24hr
163	3	MA0601.1	Arid3b	MA0601.1	ATATTAATWAN	Arid3b	1.17e-35	3.51e-38	34400	57.4	43200	53.9	1.06	EPI_DAR_24hr
164	5	MA0143.4	SOX2	MA0143.4	DNACAATGGNN	SOX2	1.26e-35	3.75e-38	52500	87.8	68400	85.4	1.03	EPI_DAR_24hr
165	24	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	1.41e-35	4.17e-38	26900	45	33300	41.5	1.08	EPI_DAR_24hr
166	3	MA0912.2	HOXD3	MA0912.2	CTAATTAC	HOXD3	3.3e-35	9.71e-38	21900	36.6	26600	33.2	1.1	EPI_DAR_24hr
167	3	MA0612.2	EMX1	MA0612.2	BTAATTAS	EMX1	4.26e-35	1.24e-37	21800	36.3	26500	33	1.1	EPI_DAR_24hr
168	1	MA0591.1	Bach1::Mafk	MA0591.1	RSSATGACTCAGCAB	Bach1::Mafk	8.48e-35	2.46e-37	2890	4.84	2780	3.46	1.4	EPI_DAR_24hr
169	3	MA0681.2	PHOX2B	MA0681.2	WWTAATCAAATTAWWW	PHOX2B	8.75e-35	2.53e-37	35700	59.7	45100	56.3	1.06	EPI_DAR_24hr
170	25	MA0108.2	TBP	MA0108.2	STATAAAWRSVVVBN	TBP	1.28e-34	3.68e-37	50100	83.7	65000	81	1.03	EPI_DAR_24hr
171	26	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	2.75e-34	7.85e-37	41900	70	53600	66.8	1.05	EPI_DAR_24hr
172	5	MA1563.2	SOX18	MA1563.2	AACAATDV	SOX18	5.78e-34	1.64e-36	47400	79.1	61100	76.3	1.04	EPI_DAR_24hr
173	3	MA0724.1	VENTX	MA0724.1	AMCGATTAR	VENTX	5.95e-34	1.68e-36	35800	59.8	45200	56.4	1.06	EPI_DAR_24hr
174	27	MA0122.3	Nkx3-2	MA0122.3	WWAAMCACTTAAN	Nkx3-2	7.91e-34	2.22e-36	46800	78.2	60300	75.3	1.04	EPI_DAR_24hr
175	12	MA0042.2	FOXI1	MA0042.2	GTAAACA	FOXI1	8.65e-34	2.41e-36	50400	84.2	65400	81.6	1.03	EPI_DAR_24hr
176	3	MA0132.2	PDX1	MA0132.2	VYAATTAR	PDX1	1.65e-33	4.56e-36	33000	55.1	41400	51.7	1.07	EPI_DAR_24hr
177	12	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	3.66e-33	1.01e-35	53600	89.5	70000	87.3	1.02	EPI_DAR_24hr
178	12	MA0031.1	FOXD1	MA0031.1	GTAAACAW	FOXD1	3.68e-33	1.01e-35	35100	58.7	44300	55.3	1.06	EPI_DAR_24hr
179	3	MA1500.1	HOXB6	MA1500.1	BTAATKRC	HOXB6	5.33e-33	1.45e-35	58700	98	77700	97	1.01	EPI_DAR_24hr
180	11	MA0909.3	Hoxd13	MA0909.3	NNCAATAAAW	Hoxd13	6.49e-33	1.76e-35	36200	60.4	45800	57.1	1.06	EPI_DAR_24hr
181	15	MA0046.2	HNF1A	MA0046.2	DRTTAATNATTAACN	HNF1A	1.23e-32	3.33e-35	24200	40.4	29800	37.2	1.09	EPI_DAR_24hr
182	12	MA1103.2	FOXK2	MA1103.2	DDGTAAACANN	FOXK2	6.23e-32	1.67e-34	53100	88.7	69300	86.5	1.03	EPI_DAR_24hr
183	10	MA0482.2	GATA4	MA0482.2	NNCCTTATCTNH	GATA4	1.91e-31	5.08e-34	50500	84.3	65600	81.8	1.03	EPI_DAR_24hr
184	3	MA0075.3	PRRX2	MA0075.3	CTAATTAN	PRRX2	2.95e-31	7.83e-34	26700	44.6	33200	41.4	1.08	EPI_DAR_24hr
185	3	MA0900.2	HOXA2	MA0900.2	STAATTAS	HOXA2	9.4e-31	2.48e-33	23300	39	28700	35.8	1.09	EPI_DAR_24hr
186	14	MA0787.1	POU3F2	MA0787.1	WTATGCWAATKA	POU3F2	2.84e-30	7.44e-33	41000	68.5	52500	65.5	1.05	EPI_DAR_24hr
187	26	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	9.03e-30	2.36e-32	52400	87.5	68400	85.3	1.03	EPI_DAR_24hr
188	3	MA0898.1	Hmx3	MA0898.1	ASAAGCAATTAAWRRAT	Hmx3	1.19e-29	3.1e-32	37300	62.4	47500	59.2	1.05	EPI_DAR_24hr
189	8	MA0682.2	PITX1	MA0682.2	YTAATCCH	PITX1	2.36e-29	6.08e-32	26900	45	33500	41.8	1.08	EPI_DAR_24hr
190	28	MA0102.4	CEBPA	MA0102.4	NDATTGCACAATHN	CEBPA	2.95e-29	7.58e-32	51800	86.6	67600	84.4	1.03	EPI_DAR_24hr
191	8	MA0467.2	Crx	MA0467.2	NDGGATTANN	Crx	3.11e-29	7.94e-32	42300	70.7	54300	67.8	1.04	EPI_DAR_24hr
192	3	MA1499.1	HOXB4	MA1499.1	RTMATTAR	HOXB4	4.82e-29	1.23e-31	33200	55.5	42000	52.4	1.06	EPI_DAR_24hr
193	14	MA0627.2	POU2F3	MA0627.2	NWTATGCAAATNH	POU2F3	7.61e-29	1.92e-31	43200	72.2	55600	69.4	1.04	EPI_DAR_24hr
194	12	MA0157.3	Foxo3	MA0157.3	NDGTAAACARNN	Foxo3	9.22e-29	2.32e-31	53600	89.6	70200	87.6	1.02	EPI_DAR_24hr
195	28	MA0025.2	NFIL3	MA0025.2	NRTTATGYAATNN	NFIL3	1.96e-28	4.89e-31	45800	76.5	59100	73.8	1.04	EPI_DAR_24hr
196	29	MA0611.2	Dux	MA0611.2	NTGATTBAATCAVWNN	Dux	2.84e-28	7.06e-31	20000	33.3	24400	30.4	1.1	EPI_DAR_24hr
197	22	MA0070.1	PBX1	MA0070.1	HCATCAATCAAW	PBX1	4.05e-28	1e-30	28000	46.8	35100	43.8	1.07	EPI_DAR_24hr
198	5	MA1562.1	SOX14	MA1562.1	CCGAACAATG	SOX14	5.54e-28	1.36e-30	46800	78.2	60600	75.6	1.03	EPI_DAR_24hr
199	5	MA0514.2	Sox3	MA0514.2	DNACAATGGNN	Sox3	1.06e-27	2.61e-30	55200	92.3	72600	90.5	1.02	EPI_DAR_24hr
200	22	MA0755.1	CUX2	MA0755.1	TRATCGATAW	CUX2	1.54e-27	3.75e-30	39800	66.5	51000	63.6	1.05	EPI_DAR_24hr
201	17	MA0497.1	MEF2C	MA0497.1	DDDCYAAAAATAGMW	MEF2C	2.74e-27	6.64e-30	39800	66.6	51000	63.6	1.05	EPI_DAR_24hr
202	3	MA0853.1	Alx4	MA0853.1	CGCRYTAATTARYHNNY	Alx4	4.19e-27	1.01e-29	28500	47.7	35800	44.6	1.07	EPI_DAR_24hr
203	3	MA0893.2	GSX2	MA0893.2	SYMATTAR	GSX2	5.74e-27	1.38e-29	56200	93.8	73900	92.3	1.02	EPI_DAR_24hr
204	3	MA0896.1	Hmx1	MA0896.1	VSVAGCAATTAAWGVDB	Hmx1	6.61e-27	1.58e-29	36600	61.2	46600	58.2	1.05	EPI_DAR_24hr
205	20	MA0117.2	Mafb	MA0117.2	AWWNTGCTGACD	Mafb	7.37e-27	1.75e-29	19100	32	23400	29.2	1.1	EPI_DAR_24hr
206	19	MA0523.1	TCF7L2	MA0523.1	DRASATCAAAGRVA	TCF7L2	1.18e-26	2.8e-29	39300	65.7	50300	62.8	1.05	EPI_DAR_24hr
207	5	MA0078.2	Sox17	MA0078.2	NNAGAACAATGGNN	Sox17	1.26e-26	2.97e-29	52000	86.9	67900	84.7	1.03	EPI_DAR_24hr
208	11	MA0878.3	CDX1	MA0878.3	GGYMATAAAA	CDX1	6.53e-26	1.53e-28	26500	44.3	33100	41.3	1.07	EPI_DAR_24hr
209	30	MA1489.1	FOXN3	MA1489.1	GTAAACAA	FOXN3	4.19e-25	9.78e-28	43400	72.5	56000	69.8	1.04	EPI_DAR_24hr
210	19	MA1991.1	Hnf1A	MA1991.1	NBCCTTTGATSTBN	Hnf1A	6.62e-25	1.54e-27	54600	91.2	71700	89.5	1.02	EPI_DAR_24hr
211	31	MA0606.2	Nfat5	MA0606.2	NNATGGAAAAWN	Nfat5	9.62e-25	2.22e-27	57400	95.9	75800	94.6	1.01	EPI_DAR_24hr
212	32	MA1124.1	ZNF24	MA1124.1	CATTCATTCATTC	ZNF24	4.13e-24	9.52e-27	34100	57	43300	54.1	1.05	EPI_DAR_24hr
213	11	MA0908.1	HOXD11	MA0908.1	RTCGTAAAAH	HOXD11	6.48e-24	1.49e-26	27400	45.8	34400	42.9	1.07	EPI_DAR_24hr
214	33	MA0018.4	CREB1	MA0018.4	NNRTGATGTCAYN	CREB1	7.53e-24	1.72e-26	44500	74.4	57600	71.8	1.04	EPI_DAR_24hr
215	12	MA0480.2	Foxo1	MA0480.2	NDGTAAACANN	Foxo1	1.08e-23	2.46e-26	56600	94.5	74600	93.1	1.01	EPI_DAR_24hr
216	33	MA1143.1	FOSL1::JUND	MA1143.1	RTGACGTMAY	FOSL1::JUND	1.24e-23	2.79e-26	14700	24.5	17700	22.1	1.11	EPI_DAR_24hr
217	34	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	2.65e-23	5.95e-26	31300	52.3	39600	49.4	1.06	EPI_DAR_24hr
218	28	MA1636.1	CEBPG	MA1636.1	NDATGATGCAATMHH	CEBPG	2.95e-23	6.61e-26	46800	78.2	60700	75.8	1.03	EPI_DAR_24hr
219	12	MA0850.1	FOXP3	MA0850.1	RTAAACA	FOXP3	3.98e-23	8.87e-26	57200	95.6	75600	94.3	1.01	EPI_DAR_24hr
220	12	MA0852.2	FOXK1	MA0852.2	NRDGTAAACAAGNN	FOXK1	6.97e-23	1.55e-25	54000	90.3	70900	88.5	1.02	EPI_DAR_24hr
221	35	MA0095.3	Yy1	MA0095.3	NNCAAAATGGCN	Yy1	2.88e-22	6.36e-25	57000	95.2	75300	93.9	1.01	EPI_DAR_24hr
222	36	MA1603.1	Dmrt1	MA1603.1	GHTACAAAGTADC	Dmrt1	4.59e-22	1.01e-24	45000	75.2	58300	72.8	1.03	EPI_DAR_24hr
223	37	MA0502.2 (NFYB)	STREME-7	7-CATTGG	CATTGG	NFYB	7.82e-22	1.71e-24	30600	51.2	38800	48.4	1.06	EPI_DAR_24hr
224	24	MA0140.2	GATA1::TAL1	MA0140.2	MTTATCWSNNNNNHVCAG	GATA1::TAL1	2.08e-21	4.53e-24	20600	34.4	25500	31.8	1.08	EPI_DAR_24hr
225	27	MA0124.2	Nkx3-1	MA0124.2	RCCACTTAA	Nkx3-1	2.33e-21	5.04e-24	44500	74.4	57700	71.9	1.03	EPI_DAR_24hr
226	3	MA0642.2	EN2	MA0642.2	VSYAATTA	EN2	2.53e-21	5.45e-24	25700	42.9	32200	40.2	1.07	EPI_DAR_24hr
227	5	MA1120.1	SOX13	MA1120.1	DVACAATGGNN	SOX13	4.1e-21	8.81e-24	50000	83.5	65300	81.4	1.03	EPI_DAR_24hr
228	11	MA0913.2	HOXD9	MA0913.2	GYMATAAAAH	HOXD9	6e-21	1.28e-23	30700	51.3	39000	48.6	1.06	EPI_DAR_24hr
229	8	MA0719.1	RHOXF1	MA0719.1	NTRATCCN	RHOXF1	1.54e-20	3.27e-23	52900	88.3	69400	86.5	1.02	EPI_DAR_24hr
230	11	MA0151.1	Arid3a	MA0151.1	ATYAAA	Arid3a	2.06e-20	4.37e-23	26100	43.6	32800	41	1.06	EPI_DAR_24hr
231	19	MA0768.2	Lef1	MA0768.2	NNBCCTTTGATSTN	Lef1	2.69e-20	5.69e-23	49400	82.6	64500	80.5	1.03	EPI_DAR_24hr
232	20	MA0842.2	NRL	MA0842.2	AAWWNTGCTGACG	NRL	4.45e-20	9.36e-23	17500	29.2	21500	26.8	1.09	EPI_DAR_24hr
233	23	MA0090.3	TEAD1	MA0090.3	NNACATTCCAGSN	TEAD1	6.49e-20	1.36e-22	51900	86.6	68000	84.8	1.02	EPI_DAR_24hr
234	38	MA1588.1	ZNF136	MA1588.1	RWATTCTTGGTTGRC	ZNF136	8.68e-20	1.81e-22	31700	52.9	40300	50.3	1.05	EPI_DAR_24hr
235	23	MA0808.1	TEAD3	MA0808.1	RCATTCCW	TEAD3	1.14e-19	2.37e-22	34700	57.9	44300	55.3	1.05	EPI_DAR_24hr
236	3	MA0715.1	PROP1	MA0715.1	TAATYWAATTA	PROP1	1.17e-19	2.42e-22	27000	45.1	34100	42.5	1.06	EPI_DAR_24hr
237	11	MA0911.1	Hoxa11	MA0911.1	RGTCGTAAAANT	Hoxa11	1.56e-19	3.22e-22	45500	76.1	59100	73.8	1.03	EPI_DAR_24hr
238	26	MA0774.1	MEIS2	MA0774.1	TTGACAGS	MEIS2	2.57e-19	5.28e-22	28900	48.2	36600	45.7	1.06	EPI_DAR_24hr
239	3	MA0914.1	ISL2	MA0914.1	GCAMTTAR	ISL2	2.81e-19	5.74e-22	44000	73.6	57100	71.3	1.03	EPI_DAR_24hr
240	5	MA0442.2	SOX10	MA0442.2	NDAACAAAGVN	SOX10	2.95e-19	6e-22	52700	88.1	69200	86.4	1.02	EPI_DAR_24hr
241	5	MA0867.2	SOX4	MA0867.2	RAACAAAGRV	SOX4	7.13e-19	1.44e-21	49900	83.4	65300	81.5	1.02	EPI_DAR_24hr
242	13	MA0877.3	BARHL1	MA0877.3	AMCGTTTA	BARHL1	1.12e-18	2.25e-21	51000	85.1	66700	83.3	1.02	EPI_DAR_24hr
243	8	MA0883.1	Dmbx1	MA0883.1	WDRWNMGGATTADKNNW	Dmbx1	3.51e-18	7.05e-21	31700	52.9	40400	50.4	1.05	EPI_DAR_24hr
244	12	MA0614.1	Foxj2	MA0614.1	RTAAACAA	Foxj2	4.9e-18	9.79e-21	19000	31.8	23600	29.5	1.08	EPI_DAR_24hr
245	3	MA0854.1	Alx1	MA0854.1	CGMRYTAATTARTNMNY	Alx1	5.23e-18	1.04e-20	25200	42.1	31800	39.6	1.06	EPI_DAR_24hr
246	22	MA0754.2	CUX1	MA0754.2	TAATCGATAM	CUX1	1.21e-17	2.41e-20	24300	40.6	30600	38.1	1.06	EPI_DAR_24hr
247	39	MA0050.3	Irf1	MA0050.3	ANTGAAACTGAAASH	Irf1	1.34e-17	2.64e-20	48900	81.7	63900	79.7	1.02	EPI_DAR_24hr
248	12	MA0849.1	FOXO6	MA0849.1	GTAAACA	FOXO6	2.36e-17	4.64e-20	5320	8.89	6040	7.53	1.18	EPI_DAR_24hr
249	3	MA1507.1	HOXD4	MA1507.1	VTMATTAD	HOXD4	2.67e-17	5.23e-20	22900	38.3	28800	36	1.07	EPI_DAR_24hr
250	3	MA1504.1	HOXC4	MA1504.1	VTMATTAN	HOXC4	3.56e-17	6.94e-20	24000	40.1	30200	37.7	1.06	EPI_DAR_24hr
251	40	MA1479.1	DMRTC2	MA1479.1	AATTGMTACATT	DMRTC2	5.01e-17	9.75e-20	45000	75.2	58600	73.1	1.03	EPI_DAR_24hr
252	41	MA0483.1	Gfi1B	MA0483.1	AAATCWCWGCH	Gfi1B	5.59e-17	1.08e-19	24900	41.6	31400	39.2	1.06	EPI_DAR_24hr
253	26	MA0775.1	MEIS3	MA0775.1	DTGACAGS	MEIS3	1.56e-16	3.01e-19	11700	19.6	14200	17.7	1.11	EPI_DAR_24hr
254	28	MA0833.2	ATF4	MA0833.2	DDATGATGCAATMN	ATF4	1.72e-16	3.3e-19	35600	59.6	45800	57.2	1.04	EPI_DAR_24hr
255	34	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	2.32e-16	4.44e-19	39400	65.8	50900	63.5	1.04	EPI_DAR_24hr
256	31	MA0624.2	Nfatc1	MA0624.2	NVATGGAAAAWN	Nfatc1	7.65e-16	1.46e-18	55300	92.4	73000	91.1	1.01	EPI_DAR_24hr
257	3	MA1960.1	MGA::EVX1	MA1960.1	RGGTGWTAATKD	MGA::EVX1	7.7e-16	1.46e-18	38700	64.7	50100	62.4	1.04	EPI_DAR_24hr
258	42	MA0689.1	TBX20	MA0689.1	WAGGTGTGAAR	TBX20	4.41e-15	8.34e-18	42900	71.7	55800	69.6	1.03	EPI_DAR_24hr
259	43	MA1593.1	ZNF317	MA1593.1	WVACAGCAGAYW	ZNF317	5.91e-15	1.11e-17	54400	90.8	71700	89.4	1.02	EPI_DAR_24hr
260	12	MA0851.1	Foxj3	MA0851.1	NDAADGTAAACAAANNM	Foxj3	7.63e-15	1.43e-17	32300	54	41500	51.7	1.04	EPI_DAR_24hr
261	44	MA1125.1	ZNF384	MA1125.1	DNWMAAAAAAAA	ZNF384	1.09e-14	2.03e-17	29200	48.7	37200	46.4	1.05	EPI_DAR_24hr
262	28	MA0836.2	CEBPD	MA0836.2	NRTTGCACAAYHN	CEBPD	1.11e-14	2.06e-17	48400	80.9	63400	79.1	1.02	EPI_DAR_24hr
263	45	MA0739.1 (Hic1)	STREME-9	9-ATGCCWD	ATGCCWD	Hic1	1.41e-14	2.62e-17	47700	79.7	62400	77.8	1.02	EPI_DAR_24hr
264	3	MA0897.1	Hmx2	MA0897.1	ASAAGCAATTAAHVVRT	Hmx2	1.74e-14	3.22e-17	28600	47.8	36500	45.5	1.05	EPI_DAR_24hr
265	46	MA1118.1	SIX1	MA1118.1	GWAACCTGAKM	SIX1	3.73e-14	6.86e-17	47600	79.5	62200	77.6	1.02	EPI_DAR_24hr
266	33	MA1632.1	ATF2	MA1632.1	NNATGABGTCATN	ATF2	6.43e-14	1.18e-16	41800	69.9	54400	67.8	1.03	EPI_DAR_24hr
267	11	MA0906.1	HOXC12	MA0906.1	RGTCGTAAAAH	HOXC12	6.68e-14	1.22e-16	22300	37.2	28100	35.1	1.06	EPI_DAR_24hr
268	47	MA1105.2	GRHL2	MA1105.2	NRAACAGGTTYN	GRHL2	6.97e-14	1.27e-16	54400	90.9	71800	89.6	1.01	EPI_DAR_24hr
269	3	MA1496.1	HOXA4	MA1496.1	RTMATTAV	HOXA4	8.23e-14	1.49e-16	23400	39	29500	36.9	1.06	EPI_DAR_24hr
270	27	MA0672.1	NKX2-3	MA0672.1	VCCACTTRAV	NKX2-3	8.39e-14	1.52e-16	6690	11.2	7870	9.82	1.14	EPI_DAR_24hr
271	46	MA1119.1	SIX2	MA1119.1	NNCTGAAACCTGATMY	SIX2	2.92e-13	5.26e-16	54900	91.8	72600	90.6	1.01	EPI_DAR_24hr
272	3	MA1463.1	ARGFX	MA1463.1	DCTAATTARM	ARGFX	3.94e-13	7.07e-16	18300	30.6	22900	28.6	1.07	EPI_DAR_24hr
273	27	MA0063.2	NKX2-5	MA0063.2	NNCACTCAANN	NKX2-5	5.91e-13	1.06e-15	55500	92.8	73400	91.6	1.01	EPI_DAR_24hr
274	39	MA1623.1	Stat2	MA1623.1	RGAAACAGAAASH	Stat2	1.48e-12	2.63e-15	49600	82.9	65100	81.2	1.02	EPI_DAR_24hr
275	27	MA2003.1	NKX2-4	MA2003.1	CCACTTSAVV	NKX2-4	1.51e-12	2.68e-15	8540	14.3	10300	12.8	1.11	EPI_DAR_24hr
276	48	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	1.66e-12	2.93e-15	26200	43.7	33400	41.6	1.05	EPI_DAR_24hr
277	49	MA1150.1	RORB	MA1150.1	AWWTRGGTCAH	RORB	2.29e-12	4.03e-15	42800	71.4	55700	69.5	1.03	EPI_DAR_24hr
278	50	MA1709.1	ZIM3	MA1709.1	RVMAACAGAAACCYM	ZIM3	8.17e-12	1.43e-14	41000	68.6	53400	66.6	1.03	EPI_DAR_24hr
279	41	MA0038.2	GFI1	MA0038.2	BMAATCACDGCA	GFI1	9.52e-12	1.67e-14	13000	21.8	16100	20.1	1.08	EPI_DAR_24hr
280	33	MA1112.2	NR4A1	MA1112.2	NNAAAGGTCANN	NR4A1	1.76e-11	3.06e-14	44500	74.3	58100	72.5	1.02	EPI_DAR_24hr
281	51	MA0106.3	TP53	MA0106.3	RACATGYCCGGRCATGTY	TP53	2.45e-11	4.25e-14	406	0.68	309	0.39	1.76	EPI_DAR_24hr
282	34	MA1523.1	MSANTD3	MA1523.1	STVCACTCAC	MSANTD3	3.71e-11	6.42e-14	58500	97.7	77800	97	1.01	EPI_DAR_24hr
283	52	MA1625.1	Stat5b	MA1625.1	NNNTTCCCAGAANNN	Stat5b	5.13e-11	8.84e-14	52400	87.5	69000	86.1	1.02	EPI_DAR_24hr
284	52	MA0144.2	STAT3	MA0144.2	YTTCYKGGAAD	STAT3	5.38e-11	9.25e-14	39200	65.4	50900	63.5	1.03	EPI_DAR_24hr
285	3	MA1501.1	HOXB7	MA1501.1	GGTAATTAVS	HOXB7	5.88e-11	1.01e-13	19700	32.9	24900	31	1.06	EPI_DAR_24hr
286	33	MA0093.3	USF1	MA0093.3	NDGTCATGTGACHN	USF1	9.8e-11	1.67e-13	44300	74	57900	72.3	1.02	EPI_DAR_24hr
287	53	MA1975.1	ZNF214	MA1975.1	VWTCATCAABGTCCT	ZNF214	1.82e-10	3.1e-13	45800	76.6	60100	74.9	1.02	EPI_DAR_24hr
288	14	MA1962.1	POU2F1::SOX2	MA1962.1	MATTTRCATMACAATRG	POU2F1::SOX2	4.88e-10	8.26e-13	17800	29.7	22400	28	1.06	EPI_DAR_24hr
289	30	MA1487.2	FOXE1	MA1487.2	VYTAAAYAAACAAH	FOXE1	5.57e-10	9.4e-13	32700	54.7	42300	52.8	1.04	EPI_DAR_24hr
290	40	MA1707.1	DMRTA1	MA1707.1	AWTTGWTACAWT	DMRTA1	5.94e-10	9.99e-13	47300	79.1	62100	77.5	1.02	EPI_DAR_24hr
291	28	MA0043.3	HLF	MA0043.3	NNRTTATGCAACHN	HLF	6.05e-10	1.01e-12	30600	51.1	39500	49.2	1.04	EPI_DAR_24hr
292	49	MA1111.1	NR2F2	MA1111.1	NAAAGGTCANR	NR2F2	7.72e-10	1.29e-12	56500	94.5	75000	93.6	1.01	EPI_DAR_24hr
293	54	MA0797.1	TGIF2	MA0797.1	TGACAGSTGTCA	TGIF2	8.45e-10	1.41e-12	14500	24.3	18200	22.7	1.07	EPI_DAR_24hr
294	47	MA1508.1	IKZF1	MA1508.1	VVAACAGGAARN	IKZF1	9.04e-10	1.5e-12	59500	99.4	79400	99.1	1	EPI_DAR_24hr
295	33	MA1131.1	FOSL2::JUN	MA1131.1	GRTGACGTMAT	FOSL2::JUN	9.58e-10	1.59e-12	39700	66.2	51700	64.4	1.03	EPI_DAR_24hr
296	55	MA0691.1	TFAP4	MA0691.1	AWCAGCTGWT	TFAP4	1.35e-09	2.23e-12	12100	20.2	15000	18.7	1.08	EPI_DAR_24hr
297	56	MA0092.1	Hand1::Tcf3	MA0092.1	BRTCTGGMWT	Hand1::Tcf3	1.96e-09	3.23e-12	47100	78.7	61800	77.2	1.02	EPI_DAR_24hr
298	57	MA0508.3	PRDM1	MA0508.3	YNCTTTCTCTH	PRDM1	3.43e-09	5.62e-12	51100	85.4	67300	84	1.02	EPI_DAR_24hr
299	58	MA0596.1	SREBF2	MA0596.1	RTGGGGTGAY	SREBF2	3.51e-09	5.72e-12	6790	11.3	8170	10.2	1.11	EPI_DAR_24hr
300	59	MA1125.1 (ZNF384)	MEME-1	TTTTTTTTTTTTTTT	TTTTTTTTTTTTTTT	ZNF384	4.7e-09	7.65e-12	29500	49.3	38000	47.4	1.04	EPI_DAR_24hr
301	11	MA0907.1	HOXC13	MA0907.1	BCTCGTAAAAH	HOXC13	4.83e-09	7.83e-12	27300	45.7	35100	43.8	1.04	EPI_DAR_24hr
302	8	MA1547.2	PITX2	MA1547.2	YTAATCCY	PITX2	5.24e-09	8.47e-12	20600	34.4	26200	32.6	1.05	EPI_DAR_24hr
303	60	MA1974.1	ZNF211	MA1974.1	HWYATATACCAYRYW	ZNF211	5.56e-09	8.95e-12	28500	47.7	36800	45.9	1.04	EPI_DAR_24hr
304	15	MA0683.1	POU4F2	MA0683.1	RTGCATAATTAATGAG	POU4F2	8.9e-09	1.43e-11	8230	13.8	10000	12.5	1.1	EPI_DAR_24hr
305	31	MA0152.2	Nfatc2	MA0152.2	NNRNAATGGAAANWNH	Nfatc2	1.23e-08	1.96e-11	53900	90	71300	88.9	1.01	EPI_DAR_24hr
306	61	MA0847.3	FOXD2	MA0847.3	SYTAARYAAACA	FOXD2	2.74e-08	4.37e-11	34300	57.3	44500	55.6	1.03	EPI_DAR_24hr
307	5	MA0515.1	Sox6	MA0515.1	CCWTTGTYYY	Sox6	3.62e-08	5.75e-11	6480	10.8	7830	9.77	1.11	EPI_DAR_24hr
308	30	MA0040.1	Foxq1	MA0040.1	HATTGTTTATW	Foxq1	5.61e-08	8.88e-11	4830	8.07	5730	7.15	1.13	EPI_DAR_24hr
309	23	MA1121.1	TEAD2	MA1121.1	NYACATTCCWNNS	TEAD2	1e-07	1.59e-10	45800	76.5	60100	75	1.02	EPI_DAR_24hr
310	3	MA0874.1	Arx	MA0874.1	VTBCRYTAATTARTKSW	Arx	1.41e-07	2.21e-10	19200	32.1	24500	30.5	1.05	EPI_DAR_24hr
311	55	MA0829.2	SREBF1	MA0829.2	DNATCACSTGATNH	SREBF1	1.99e-07	3.11e-10	41500	69.4	54400	67.8	1.02	EPI_DAR_24hr
312	29	MA0884.2	DUXA	MA0884.2	YTRATTWAATYAR	DUXA	2.29e-07	3.58e-10	10400	17.3	12900	16.1	1.08	EPI_DAR_24hr
313	49	MA1151.1	RORC	MA1151.1	NWAWNTRGGTCA	RORC	3.7e-07	5.76e-10	36700	61.4	47900	59.7	1.03	EPI_DAR_24hr
314	58	MA0595.1	SREBF1	MA0595.1	VTCACCCCAY	SREBF1	3.89e-07	6.04e-10	9910	16.6	12300	15.3	1.08	EPI_DAR_24hr
315	19	MA0869.2	Sox11	MA0869.2	NRGAACAAAGVV	Sox11	5.84e-07	9.05e-10	57400	96	76400	95.3	1.01	EPI_DAR_24hr
316	5	MA0087.2	Sox5	MA0087.2	VRVAACAATGGNN	Sox5	6.13e-07	9.46e-10	43700	73.1	57400	71.6	1.02	EPI_DAR_24hr
317	62	MA0479.1	FOXH1	MA0479.1	BNSAATCCACA	FOXH1	1.56e-06	2.39e-09	8340	13.9	10300	12.8	1.08	EPI_DAR_24hr
318	22	MA0756.2	ONECUT2	MA0756.2	CGATCRATA	ONECUT2	1.94e-06	2.97e-09	13000	21.6	16300	20.4	1.06	EPI_DAR_24hr
319	55	MA0698.1	ZBTB18	MA0698.1	NATCCAGATGTKB	ZBTB18	1.96e-06	3e-09	22700	37.9	29100	36.4	1.04	EPI_DAR_24hr
320	63	MA1729.1	ZNF680	MA1729.1	GNCCAAGAAGAATDA	ZNF680	2.25e-06	3.43e-09	32900	54.9	42800	53.3	1.03	EPI_DAR_24hr
321	11	MA1503.1	HOXB9	MA1503.1	GTCGTAAAAH	HOXB9	2.7e-06	4.1e-09	5210	8.7	6280	7.83	1.11	EPI_DAR_24hr
322	52	MA1624.1	Stat5a	MA1624.1	NTTCCAAGAANH	Stat5a	3.56e-06	5.4e-09	48100	80.4	63400	79.1	1.02	EPI_DAR_24hr
323	54	MA0667.1	MYF6	MA0667.1	AACARCTGTT	MYF6	3.74e-06	5.65e-09	14700	24.6	18700	23.3	1.06	EPI_DAR_24hr
324	22	MA0757.1	ONECUT3	MA0757.1	AAAAAATCRATAAH	ONECUT3	4.32e-06	6.5e-09	10900	18.2	13600	17	1.07	EPI_DAR_24hr
325	33	MA1127.1	FOSB::JUN	MA1127.1	GATGACGTCAT	FOSB::JUN	4.52e-06	6.79e-09	43800	73.2	57500	71.8	1.02	EPI_DAR_24hr
326	3	MA0618.1	LBX1	MA0618.1	TTAATTAG	LBX1	4.97e-06	7.43e-09	14100	23.6	17900	22.3	1.06	EPI_DAR_24hr
327	64	MA1592.1	ZNF274	MA1592.1	NRTRTGAGTTCTCGYN	ZNF274	6.09e-06	9.08e-09	13900	23.3	17600	22	1.06	EPI_DAR_24hr
328	11	MA0873.1	HOXD12	MA0873.1	RGTCGTAAAAH	HOXD12	7.76e-06	1.15e-08	11100	18.5	13900	17.3	1.07	EPI_DAR_24hr
329	33	MA0488.1	JUN	MA0488.1	DDRATGATGTCAT	JUN	9.23e-06	1.37e-08	12000	20	15100	18.8	1.06	EPI_DAR_24hr
330	65	MA0671.1	NFIX	MA0671.1	NNTGCCAAN	NFIX	1.09e-05	1.61e-08	59700	99.7	79700	99.5	1	EPI_DAR_24hr
331	33	MA0693.3	Vdr	MA0693.3	NNGAGTTCANN	Vdr	2.23e-05	3.28e-08	58200	97.2	77500	96.7	1.01	EPI_DAR_24hr
332	3	MA0780.1	PAX3	MA0780.1	TAATYRATTA	PAX3	2.62e-05	3.85e-08	15500	25.9	19800	24.7	1.05	EPI_DAR_24hr
333	23	MA0484.2	HNF4G	MA0484.2	DNCAAAGTCCANN	HNF4G	4.16e-05	6.1e-08	51900	86.7	68700	85.7	1.01	EPI_DAR_24hr
334	23	MA0114.4	HNF4A	MA0114.4	DNCAAAGTCCANN	HNF4A	5e-05	7.3e-08	54300	90.8	72100	90	1.01	EPI_DAR_24hr
335	11	MA1506.1	HOXD10	MA1506.1	RGTCGTAAAAH	HOXD10	5.65e-05	8.23e-08	10700	17.9	13500	16.8	1.06	EPI_DAR_24hr
336	49	MA0258.2	ESR2	MA0258.2	AGGTCASVNTGMCCY	ESR2	6.17e-05	8.97e-08	52800	88.2	69900	87.3	1.01	EPI_DAR_24hr
337	52	MA0519.1	Stat5a::Stat5b	MA0519.1	DTTTCCMAGAA	Stat5a::Stat5b	6.55e-05	9.48e-08	30500	51	39700	49.5	1.03	EPI_DAR_24hr
338	65	MA0161.2	NFIC	MA0161.2	NNCTTGGCANN	NFIC	7.78e-05	1.12e-07	31700	53	41400	51.6	1.03	EPI_DAR_24hr
339	42	MA0802.1	TBR1	MA0802.1	AGGTGTGAAA	TBR1	8.06e-05	1.16e-07	48500	81	64000	79.9	1.01	EPI_DAR_24hr
340	37	MA0502.2	NFYB	MA0502.2	CYCATTGGCCVV	NFYB	0.000122	1.75e-07	1900	3.17	2160	2.7	1.17	EPI_DAR_24hr
341	48	MA0461.2	Atoh1	MA0461.2	RMCATATGBY	Atoh1	0.000128	1.83e-07	49400	82.6	65300	81.5	1.01	EPI_DAR_24hr
342	65	MA1527.1	NFIC	MA1527.1	NTTGGCDNNRTGCCARN	NFIC	0.000142	2.03e-07	3840	6.42	4620	5.76	1.11	EPI_DAR_24hr
343	27	MA1994.1	Nkx2-1	MA1994.1	NVCACTTGARHNN	Nkx2-1	0.000154	2.19e-07	23800	39.7	30800	38.4	1.03	EPI_DAR_24hr
344	66	MA0065.2	Pparg::Rxra	MA0065.2	STRGGGCARAGGKCA	Pparg::Rxra	0.000169	2.39e-07	59300	99	79100	98.7	1	EPI_DAR_24hr
345	17	MA0773.1	MEF2D	MA0773.1	DCTAWAAATAGM	MEF2D	0.000176	2.48e-07	8030	13.4	10000	12.5	1.07	EPI_DAR_24hr
346	54	MA0669.1	NEUROG2	MA0669.1	RACATATGTC	NEUROG2	0.000195	2.76e-07	21200	35.5	27400	34.2	1.04	EPI_DAR_24hr
347	67	MA0640.2	ELF3	MA0640.2	NNCCACTTCCTGNT	ELF3	0.000246	3.47e-07	59200	99	79100	98.7	1	EPI_DAR_24hr
348	52	MA1579.1	ZBTB26	MA1579.1	NNCTCCAGAAANNNN	ZBTB26	0.000251	3.52e-07	56200	93.9	74800	93.3	1.01	EPI_DAR_24hr
349	51	MA0525.2	TP63	MA0525.2	RACATGTYGKGACATGTC	TP63	0.000268	3.75e-07	196	0.33	153	0.19	1.71	EPI_DAR_24hr
350	54	MA1618.1	Ptf1a	MA1618.1	NNACAGATGTTNN	Ptf1a	0.000304	4.25e-07	32000	53.5	41800	52.1	1.03	EPI_DAR_24hr
351	3	MA1577.1	TLX2	MA1577.1	BYAATTAR	TLX2	0.000356	4.95e-07	15000	25.1	19200	24	1.05	EPI_DAR_24hr
352	40	MA1478.1	DMRTA2	MA1478.1	AATTGHTACAWT	DMRTA2	0.000426	5.91e-07	51300	85.8	68000	84.8	1.01	EPI_DAR_24hr
353	27	MA1645.1	NKX2-2	MA1645.1	NNNCCACTCAANNN	NKX2-2	0.000661	9.14e-07	53700	89.8	71300	89	1.01	EPI_DAR_24hr
354	65	MA0670.1	NFIA	MA0670.1	NDTGCCAAND	NFIA	0.000703	9.7e-07	7090	11.8	8840	11	1.07	EPI_DAR_24hr
355	50	MA1953.1	FOXO1::ELF1	MA1953.1	RTMAACAGGAAGTN	FOXO1::ELF1	0.000745	1.02e-06	36200	60.5	47500	59.3	1.02	EPI_DAR_24hr
356	48	MA1108.2	MXI1	MA1108.2	NNCACATGBN	MXI1	0.000942	1.29e-06	37500	62.6	49200	61.4	1.02	EPI_DAR_24hr
357	52	MA1116.1	RBPJ	MA1116.1	BVTGGGAANN	RBPJ	0.00108	1.48e-06	54600	91.2	72500	90.4	1.01	EPI_DAR_24hr
358	42	MA0800.1	EOMES	MA0800.1	RAGGTGTGAAAWN	EOMES	0.00122	1.66e-06	46600	77.9	61600	76.8	1.01	EPI_DAR_24hr
359	12	MA0593.1	FOXP2	MA0593.1	RWGTAAACAVR	FOXP2	0.00151	2.05e-06	3460	5.78	4180	5.21	1.11	EPI_DAR_24hr
360	51	MA0861.1	TP73	MA0861.1	DRCATGTCNNRACAYGYM	TP73	0.00164	2.23e-06	278	0.46	248	0.31	1.5	EPI_DAR_24hr
361	12	MA0613.1	FOXG1	MA0613.1	RTAAACAW	FOXG1	0.00179	2.42e-06	7280	12.2	9100	11.4	1.07	EPI_DAR_24hr
362	33	MA1139.1	FOSL2::JUNB	MA1139.1	DATGACGTCATH	FOSL2::JUNB	0.00229	3.08e-06	32300	54	42300	52.8	1.02	EPI_DAR_24hr
363	65	MA0119.1	NFIC::TLX1	MA0119.1	TGGCASSRWGCCAA	NFIC::TLX1	0.00257	3.46e-06	2000	3.34	2340	2.92	1.15	EPI_DAR_24hr
364	31	MA0625.2	NFATC3	MA0625.2	RYGGAAAMH	NFATC3	0.00389	5.21e-06	58700	98.1	78300	97.7	1	EPI_DAR_24hr
365	33	MA1145.1	FOSL2::JUND	MA1145.1	NNRTGACGTCAYHSN	FOSL2::JUND	0.00417	5.57e-06	42100	70.4	55600	69.3	1.02	EPI_DAR_24hr
366	48	MA1638.1	HAND2	MA1638.1	NVCAGATGNN	HAND2	0.00471	6.27e-06	9630	16.1	12200	15.2	1.06	EPI_DAR_24hr
367	26	MA1114.1	PBX3	MA1114.1	NNNTGAGTGACAGGBNN	PBX3	0.00539	7.17e-06	5300	8.86	6570	8.2	1.08	EPI_DAR_24hr
11	69	5-CCTCCCAAAG	STREME-5	5-CCTCCCAAAG	CCTCCCAAAG	CCTCCCAAAG	0.0057	0.000518	1490	2.5	1780	2.22	1.12	EPI_DAR_24hr
368	48	MA0620.3	MITF	MA0620.3	NNNDRTCACGTGAYHNNN	MITF	0.007	9.29e-06	6620	11.1	8280	10.3	1.07	EPI_DAR_24hr
369	48	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	0.00869	1.15e-05	8540	14.3	10800	13.5	1.06	EPI_DAR_24hr
370	52	MA0520.1	Stat6	MA0520.1	BDBTTCCWSAGAAVY	Stat6	0.00878	1.16e-05	19700	32.9	25500	31.8	1.03	EPI_DAR_24hr
371	66	MA0160.2	NR4A2	MA0160.2	BWAAAGGTCA	NR4A2	0.00929	1.22e-05	47400	79.3	62800	78.3	1.01	EPI_DAR_24hr
372	46	MA2001.1	Six4	MA2001.1	GDAACCTGANH	Six4	0.0106	1.38e-05	22100	36.8	28700	35.8	1.03	EPI_DAR_24hr
373	48	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	0.0106	1.38e-05	8290	13.9	10500	13.1	1.06	EPI_DAR_24hr
374	3	MA0621.1	mix-a	MA0621.1	NDTTAATTAGN	mix-a	0.0109	1.42e-05	13400	22.4	17200	21.5	1.04	EPI_DAR_24hr
375	11	MA0485.2	HOXC9	MA0485.2	GTCGTAAAAH	HOXC9	0.0114	1.49e-05	1850	3.09	2170	2.7	1.14	EPI_DAR_24hr
376	52	MA0518.1	Stat4	MA0518.1	YTTCYRGGAARNVR	Stat4	0.0142	1.84e-05	31000	51.7	40600	50.6	1.02	EPI_DAR_24hr
377	33	MA1126.1	FOS::JUN	MA1126.1	DRTGACGTCATHNDTN	FOS::JUN	0.0265	3.43e-05	43200	72.1	57000	71.1	1.01	EPI_DAR_24hr
12	70	MA1630.2 (ZNF281)	STREME-8	8-CCCCTTCCCCCAG	CCCCTTCCCCCAG	ZNF281	0.029	0.00242	593	0.99	675	0.84	1.18	EPI_DAR_24hr
378	48	MA1635.1	BHLHE22	MA1635.1	NVCAGCTGBN	BHLHE22	0.0344	4.44e-05	8410	14	10700	13.3	1.06	EPI_DAR_24hr
379	68	MA0083.3	SRF	MA0083.3	TGMCCATATATGGKCA	SRF	0.0377	4.85e-05	147	0.25	121	0.15	1.62	EPI_DAR_24hr
380	3	MA0135.1	Lhx3	MA0135.1	WAATTAATTAWYY	Lhx3	0.038	4.88e-05	11700	19.6	15000	18.7	1.04	EPI_DAR_24hr
381	48	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	0.0437	5.59e-05	8520	14.2	10800	13.5	1.05	EPI_DAR_24hr
13	71	MA0090.3 (TEAD1)	MEME-4	GGCTGGAGTGCAGTG	GGCTGGAGTGCAGTG	TEAD1	6.23	0.48	1610	2.69	2150	2.68	1.01	EPI_DAR_24hr
14	70	MA0528.2 (ZNF263)	MEME-3	GGSBGRGGSWGGRGG	GGSBGRGGSWGGRGG	ZNF263	13.7	0.975	118	0.2	197	0.25	0.805	EPI_DAR_24hr

ER_rat <- 1.25
mrc_type <- "EPI_DAR_24hr"
EPI_DAR_24hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

EPI_DAR_24hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  dplyr::filter(EVALUE.y<0.05) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*.8), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.8,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

EPI_DAR 24 2kb data

EPI_242kb_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_24_2kb_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
EPI_242kb_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_24_2kb_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
EPI_242kb_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_24_2kb_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
EPI_242kb_sea_all <- rbind(EPI_242kb_sea_disc, EPI_242kb_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

EPI_242kb_combo <- EPI_242kb_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., EPI_242kb_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

EPI_242kb_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EPI_24 2kb") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in EPI_24 2kb
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	5.97e-108	2.06e-108	1050	8.35	564	2.77	3.01
2	1	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	1.9e-107	3.27e-108	1600	12.8	1150	5.64	2.26
3	1	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	2.44e-104	2.81e-105	1630	12.9	1190	5.85	2.21
4	1	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	1.12e-103	9.65e-105	1280	10.2	816	4.01	2.54
5	1	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	1.68e-102	1.16e-103	1110	8.81	644	3.16	2.78
6	1	MA0476.1 (FOS)	MEME-4	TGASTCAT	TGASTCAT	FOS	2.59e-101	1.49e-102	1360	10.8	905	4.45	2.42
7	1	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	3.34e-101	1.65e-102	959	7.62	503	2.47	3.08
8	1	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	3.95e-101	1.71e-102	1740	13.8	1330	6.54	2.11
9	1	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	1.01e-100	3.87e-102	1830	14.5	1440	7.08	2.05
10	1	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	1.24e-100	4.29e-102	1780	14.1	1380	6.8	2.08
11	1	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	3.98e-99	1.25e-100	2010	16	1670	8.19	1.95
12	1	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	5.42e-99	1.56e-100	1870	14.8	1500	7.37	2.01
13	1	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	6.89e-99	1.83e-100	2070	16.4	1740	8.54	1.92
14	1	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	2.18e-98	5.38e-100	1020	8.1	572	2.81	2.88
15	1	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	2.08e-97	4.79e-99	1760	14	1380	6.77	2.06
16	1	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	2.47e-97	5.33e-99	1070	8.47	623	3.06	2.77
17	1	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	4.24e-96	8.6e-98	1620	12.9	1230	6.06	2.13
18	1	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	5.28e-96	1.01e-97	916	7.28	482	2.37	3.07
19	1	MA0477.2 (FOSL1)	STREME-1	1-DDDATGASTCATHHH	DDDATGASTCATHHH	FOSL1	8.92e-96	1.62e-97	1850	14.7	1500	7.35	2
20	1	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	2.36e-92	4.08e-94	1080	8.57	657	3.23	2.65
21	1	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	4.67e-92	7.68e-94	1610	12.8	1240	6.09	2.1
22	1	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	6.85e-91	1.07e-92	1640	13.1	1290	6.33	2.06
23	1	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	7.85e-86	1.18e-87	1420	11.3	1060	5.23	2.16
24	1	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	4.02e-84	5.79e-86	708	5.63	333	1.64	3.43
25	1	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	2.75e-78	3.79e-80	1630	13	1360	6.66	1.95
26	1	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	9.01e-74	1.2e-75	2420	19.2	2390	11.7	1.64
27	1	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	1.52e-70	1.94e-72	2530	20.1	2570	12.6	1.6
28	1	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	5.19e-62	6.4e-64	2410	19.1	2480	12.2	1.57
29	1	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	4.14e-60	4.93e-62	2930	23.3	3220	15.8	1.47
30	1	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	2.92e-59	3.36e-61	2600	20.7	2770	13.6	1.52
31	2	3-AGKYATSW	STREME-3	3-AGKYATSW	AGKYATSW	AGKYATSW	4.18e-56	4.66e-58	6660	52.9	8910	43.8	1.21
32	3	MA0704.1	Lhx4	MA0704.1	YTAATTAR	Lhx4	1.81e-54	1.95e-56	6750	53.7	9090	44.6	1.2
33	3	MA0710.1	NOTO	MA0710.1	NYTAATTAVN	NOTO	7.6e-54	7.95e-56	8170	65	11400	56.2	1.16
34	4	MA1963.1	SATB1	MA1963.1	WWDCTAATAAHWW	SATB1	9.1e-54	9.24e-56	6560	52.1	8780	43.1	1.21
35	3	MA0722.1	VAX1	MA0722.1	YTAATTAH	VAX1	2.15e-52	2.13e-54	8900	70.7	12700	62.3	1.13
36	1	MA1639.1	MEIS1	MA1639.1	NHCATMAATCAHN	MEIS1	5.15e-52	4.94e-54	6590	52.3	8860	43.5	1.2
37	5	MA0882.1	DLX6	MA0882.1	VYAATTAN	DLX6	1.48e-50	1.38e-52	7350	58.4	10100	49.7	1.17
38	5	MA0642.2 (EN2)	STREME-2	2-ATTRGM	ATTRGM	EN2	1.77e-50	1.61e-52	6240	49.6	8340	41	1.21
39	3	MA0723.2	VAX2	MA0723.2	BYAATTAV	VAX2	3.69e-50	3.27e-52	7450	59.2	10300	50.6	1.17
40	1	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	5.78e-50	4.99e-52	2370	18.8	2560	12.6	1.5
41	3	MA0661.1	MEOX1	MA0661.1	VSTAATTAHC	MEOX1	2.04e-49	1.72e-51	8340	66.3	11800	57.9	1.14
42	5	MA0720.1	Shox2	MA0720.1	YYAATTAR	Shox2	6.85e-48	5.63e-50	6380	50.7	8600	42.2	1.2
43	6	MA0885.2	Dlx2	MA0885.2	NDGCAATTAGNN	Dlx2	8.25e-48	6.62e-50	7690	61.1	10700	52.7	1.16
44	7	MA1113.2	PBX2	MA1113.2	NHCATAAATCAHN	PBX2	1.59e-47	1.24e-49	6380	50.7	8610	42.3	1.2
45	8	4-TMTSAKA	STREME-4	4-TMTSAKA	TMTSAKA	TMTSAKA	1.61e-47	1.24e-49	6360	50.5	8570	42.1	1.2
46	9	MA0495.3	MAFF	MA0495.3	DWGTCAGCATTTTWHN	MAFF	2.16e-47	1.62e-49	6980	55.5	9580	47.1	1.18
47	1	MA0150.2	Nfe2l2	MA0150.2	CASNATGACTCAGCA	Nfe2l2	6.77e-47	4.97e-49	3300	26.2	3910	19.2	1.36
48	5	MA0721.1	UNCX	MA0721.1	YYAATTAV	UNCX	1.3e-46	9.36e-49	7010	55.7	9640	47.4	1.18
49	10	MA0789.1	POU3F4	MA0789.1	TATGCWAAT	POU3F4	1.56e-46	1.1e-48	6960	55.3	9560	47	1.18
50	5	MA0644.2	ESX1	MA0644.2	YYAATTAN	ESX1	1.16e-44	7.99e-47	6100	48.5	8220	40.4	1.2
51	3	MA0681.2	PHOX2B	MA0681.2	WWTAATCAAATTAWWW	PHOX2B	1.38e-44	9.35e-47	6090	48.4	8190	40.2	1.2
52	6	MA1476.2	Dlx5	MA1476.2	NDGCAATTAGNN	Dlx5	5.46e-44	3.63e-46	7590	60.3	10600	52.2	1.15
53	3	MA0675.1	NKX6-2	MA0675.1	NYMATTAA	NKX6-2	5.69e-44	3.71e-46	6000	47.7	8070	39.6	1.2
54	3	MA0680.2	Pax7	MA0680.2	DWTAATCAATTAWNH	Pax7	7.05e-44	4.51e-46	6500	51.7	8860	43.6	1.19
55	5	MA0880.1	Dlx3	MA0880.1	NYAATTAN	Dlx3	1.54e-43	9.69e-46	6020	47.8	8100	39.8	1.2
56	3	MA0628.1	POU6F1	MA0628.1	AYTAATTART	POU6F1	1.95e-43	1.2e-45	8460	67.2	12100	59.4	1.13
57	5	MA0650.3	Hoxa13	MA0650.3	NNCCAATAAAAN	Hoxa13	2.69e-43	1.63e-45	8390	66.7	12000	58.9	1.13
58	5	MA0634.1	ALX3	MA0634.1	YYYAATTANV	ALX3	2.99e-43	1.78e-45	8470	67.3	12100	59.6	1.13
59	3	MA0853.1	Alx4	MA0853.1	CGCRYTAATTARYHNNY	Alx4	6.26e-43	3.66e-45	5220	41.5	6860	33.7	1.23
60	3	MA0726.1	VSX2	MA0726.1	CTAATTAN	VSX2	7.33e-43	4.22e-45	10200	81.2	15200	74.5	1.09
61	11	WARAAWAAAAWAAWA	MEME-1	WARAAWAAAAWAAWA	WARAAWAAAAWAAWA	WARAAWAAAAWAAWA	1.36e-42	7.69e-45	6950	55.2	9610	47.2	1.17
62	5	MA0718.1	RAX	MA0718.1	RYYAATTARH	RAX	4.95e-42	2.75e-44	6070	48.2	8210	40.3	1.2
63	12	MA0052.4	MEF2A	MA0052.4	DDCTAAAAATAGMHH	MEF2A	1.67e-41	9.15e-44	6750	53.6	9300	45.7	1.17
64	3	MA0793.1	POU6F2	MA0793.1	ASCTMATTAW	POU6F2	3.09e-41	1.67e-43	7250	57.6	10100	49.7	1.16
65	13	MA0077.1	SOX9	MA0077.1	CYATTGTTY	SOX9	3.25e-41	1.73e-43	9290	73.9	13600	66.6	1.11
66	5	MA0713.1	PHOX2A	MA0713.1	TAATYYAATTA	PHOX2A	7.02e-41	3.67e-43	5360	42.6	7110	34.9	1.22
67	5	MA0700.2	LHX2	MA0700.2	DDCCAATTADN	LHX2	1.05e-40	5.41e-43	7560	60.1	10600	52.3	1.15
68	14	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	1.4e-40	7.09e-43	5910	47	7980	39.2	1.2
69	3	MA0674.1	NKX6-1	MA0674.1	NTMATTAA	NKX6-1	1.87e-40	9.38e-43	10000	79.5	14800	72.8	1.09
70	5	MA0889.1	GBX1	MA0889.1	VCYAATTASY	GBX1	1.98e-40	9.75e-43	6810	54.1	9420	46.3	1.17
71	15	MA1104.2	GATA6	MA1104.2	HWWTCTTATCTNH	GATA6	2.58e-40	1.26e-42	5060	40.3	6670	32.8	1.23
72	3	MA0886.1	EMX2	MA0886.1	VBTAATTARB	EMX2	3.73e-40	1.79e-42	6000	47.7	8140	40	1.19
73	3	MA1518.2	Lhx1	MA1518.2	NNNTGCTAATTAGCANNN	Lhx1	1.49e-39	7.04e-42	6710	53.3	9280	45.6	1.17
74	3	MA0887.1	EVX1	MA0887.1	VVTAATTABS	EVX1	1.75e-39	8.1e-42	7700	61.2	10900	53.6	1.14
75	5	MA0901.2	HOXB13	MA0901.2	WDCCAATAAAAWWW	HOXB13	1.76e-39	8.1e-42	7310	58.1	10300	50.4	1.15
76	16	MA0676.1	Nr2e1	MA0676.1	AAAAGTCAA	Nr2e1	1.79e-39	8.11e-42	8590	68.3	12400	60.9	1.12
77	13	MA0084.1	SRY	MA0084.1	NWWAACAAT	SRY	1.88e-39	8.45e-42	9450	75.1	13900	68.1	1.1
78	3	MA0725.1	VSX1	MA0725.1	YTAATTAN	VSX1	2.3e-39	1.02e-41	5390	42.8	7190	35.3	1.21
79	3	MA1495.1	HOXA1	MA1495.1	STAATTAS	HOXA1	3.22e-39	1.41e-41	4910	39	6450	31.7	1.23
80	5	MA0881.1	Dlx4	MA0881.1	VYAATTAN	Dlx4	4.9e-39	2.12e-41	5420	43.1	7250	35.6	1.21
81	3	MA0706.1	MEOX2	MA0706.1	DSTAATTAWN	MEOX2	1.24e-38	5.3e-41	5200	41.3	6910	33.9	1.22
82	10	MA1115.1	POU5F1	MA1115.1	WHATGCAAATN	POU5F1	3.5e-38	1.47e-40	6710	53.3	9310	45.7	1.17
83	5	MA0630.1	SHOX	MA0630.1	HTAATTRR	SHOX	4.65e-38	1.93e-40	5330	42.3	7120	35	1.21
84	3	MA1530.1	NKX6-3	MA1530.1	VYCATTAWW	NKX6-3	5.8e-38	2.36e-40	5730	45.6	7760	38.1	1.2
85	5	MA0662.1	MIXL1	MA0662.1	NBYAATTAVN	MIXL1	5.82e-38	2.36e-40	6480	51.5	8950	44	1.17
86	3	MA0904.2	HOXB5	MA0904.2	STAATTAS	HOXB5	6.45e-38	2.59e-40	6840	54.4	9530	46.8	1.16
87	6	MA0035.4	GATA1	MA0035.4	NHCTAATCTDH	GATA1	9.74e-38	3.87e-40	5770	45.9	7820	38.4	1.19
88	3	MA0788.1	POU3F3	MA0788.1	WWTATGCWAATTW	POU3F3	1.19e-37	4.68e-40	6310	50.2	8680	42.6	1.18
89	3	MA0903.1	HOXB3	MA0903.1	NNYMATTARN	HOXB3	2.33e-37	9.05e-40	7910	62.9	11300	55.5	1.13
90	5	MA0709.1	Msx3	MA0709.1	SCAATTAN	Msx3	4.17e-37	1.6e-39	5030	40	6680	32.8	1.22
91	6	MA0122.3	Nkx3-2	MA0122.3	WWAAMCACTTAAN	Nkx3-2	1.16e-36	4.39e-39	8350	66.3	12000	59.1	1.12
92	1	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	1.31e-36	4.91e-39	5240	41.6	7010	34.4	1.21
93	13	MA1562.1	SOX14	MA1562.1	CCGAACAATG	SOX14	1.56e-36	5.78e-39	7830	62.2	11200	54.9	1.13
94	6	MA1978.1	ZNF354A	MA1978.1	HWAADWATAAATGRAYWAWTT	ZNF354A	1.64e-36	6.01e-39	8800	70	12800	63	1.11
95	10	MA0792.1	POU5F1B	MA0792.1	TATGCWAAT	POU5F1B	2.46e-36	8.95e-39	6090	48.4	8350	41	1.18
96	3	MA1463.1	ARGFX	MA1463.1	DCTAATTARM	ARGFX	3.35e-36	1.2e-38	4670	37.1	6130	30.1	1.23
97	14	MA0032.2	FOXC1	MA0032.2	WAWGTAAAYAW	FOXC1	3.47e-36	1.23e-38	6130	48.7	8420	41.4	1.18
98	17	MA0809.2	TEAD4	MA0809.2	NNACATTCCARN	TEAD4	3.75e-36	1.32e-38	9610	76.4	14200	69.8	1.09
99	3	MA1519.1	LHX5	MA1519.1	STAATTAV	LHX5	4.37e-36	1.52e-38	4100	32.6	5270	25.9	1.26
100	3	MA0910.2	HOXD8	MA0910.2	GYMATTAM	HOXD8	6.79e-36	2.34e-38	5340	42.4	7170	35.2	1.2
101	18	MA0025.2	NFIL3	MA0025.2	NRTTATGYAATNN	NFIL3	9.01e-36	3.08e-38	6930	55.1	9720	47.7	1.15
102	3	MA0701.2	LHX9	MA0701.2	CYAATTAR	LHX9	1.54e-35	5.21e-38	4450	35.4	5810	28.6	1.24
103	19	7-ATAACA	STREME-7	7-ATAACA	ATAACA	ATAACA	1.84e-35	6.18e-38	7740	61.5	11100	54.3	1.13
104	3	MA0900.2	HOXA2	MA0900.2	STAATTAS	HOXA2	3.25e-35	1.08e-37	4170	33.2	5390	26.5	1.25
105	7	MA1640.1	MEIS2	MA1640.1	NNATGATTTATGDNH	MEIS2	3.27e-35	1.08e-37	4740	37.6	6250	30.7	1.22
106	5	MA0654.1	ISX	MA0654.1	YYAATTAR	ISX	3.65e-35	1.19e-37	4860	38.6	6440	31.7	1.22
107	3	MA1502.1	HOXB8	MA1502.1	GYMATTAM	HOXB8	5.48e-35	1.77e-37	5280	41.9	7100	34.9	1.2
108	3	MA0068.2	PAX4	MA0068.2	CTAATTAG	PAX4	6.78e-35	2.17e-37	5220	41.5	7010	34.5	1.2
109	6	MA0899.1	HOXA10	MA0899.1	DGYMATAAAAH	HOXA10	6.89e-35	2.18e-37	8930	71	13100	64.2	1.11
110	13	MA0078.2	Sox17	MA0078.2	NNAGAACAATGGNN	Sox17	7.97e-35	2.5e-37	8840	70.2	12900	63.4	1.11
111	15	MA1970.1	TRPS1	MA1970.1	NHTCTTATCTNH	TRPS1	8.6e-35	2.68e-37	4640	36.9	6120	30.1	1.23
112	5	MA0717.1	RAX2	MA0717.1	YYAATTAV	RAX2	9.58e-35	2.95e-37	5450	43.3	7370	36.2	1.2
113	6	MA1549.1	POU6F1	MA1549.1	RTAATGAGVN	POU6F1	1.5e-34	4.57e-37	5320	42.3	7180	35.3	1.2
114	14	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	1.6e-34	4.86e-37	8400	66.8	12200	59.8	1.12
115	3	MA0854.1	Alx1	MA0854.1	CGMRYTAATTARTNMNY	Alx1	2.6e-34	7.81e-37	4680	37.2	6190	30.4	1.22
116	5	MA0909.3	Hoxd13	MA0909.3	NNCAATAAAW	Hoxd13	3.17e-34	9.45e-37	6600	52.4	9210	45.3	1.16
117	15	MA0036.3	GATA2	MA0036.3	NBCTTATCTNH	GATA2	4.5e-34	1.33e-36	4990	39.7	6670	32.8	1.21
118	5	MA0602.1	Arid5a	MA0602.1	SYAATATTGVDANH	Arid5a	6.41e-34	1.87e-36	7200	57.2	10200	50.1	1.14
119	6	MA0712.2	OTX2	MA0712.2	NDRGGATTARNN	OTX2	6.44e-34	1.87e-36	9180	73	13500	66.4	1.1
120	3	MA0892.1	GSX1	MA0892.1	NCYMATTAVN	GSX1	1.24e-33	3.56e-36	8830	70.2	12900	63.4	1.11
121	15	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	1.34e-33	3.83e-36	4930	39.2	6580	32.3	1.21
122	14	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	2.13e-33	6.04e-36	10200	81.4	15400	75.6	1.08
123	20	MA0108.2	TBP	MA0108.2	STATAAAWRSVVVBN	TBP	2.77e-33	7.76e-36	9050	71.9	13300	65.3	1.1
124	6	MA0157.3	Foxo3	MA0157.3	NDGTAAACARNN	Foxo3	5.63e-33	1.57e-35	9540	75.8	14200	69.5	1.09
125	5	MA0699.1	LBX2	MA0699.1	NCYAATTARN	LBX2	8.5e-33	2.35e-35	5030	40	6750	33.2	1.2
126	3	MA0601.1	Arid3b	MA0601.1	ATATTAATWAN	Arid3b	1.04e-32	2.84e-35	5650	44.9	7720	38	1.18
127	6	MA1608.1	Isl1	MA1608.1	NNCCATTAGNN	Isl1	1.05e-32	2.84e-35	8750	69.5	12800	62.8	1.11
128	5	MA1481.1	DRGX	MA1481.1	YYAATTAN	DRGX	1.51e-32	4.06e-35	4550	36.1	6020	29.6	1.22
129	14	MA0148.4	FOXA1	MA0148.4	WWGTAAACATNN	FOXA1	1.52e-32	4.07e-35	6680	53.1	9380	46.1	1.15
130	21	MA0905.1	HOXC10	MA0905.1	GTCRTAAAAH	HOXC10	1.69e-32	4.5e-35	7240	57.6	10300	50.6	1.14
131	22	MA0153.2	HNF1B	MA0153.2	GTTAATNATTAAY	HNF1B	2.75e-32	7.24e-35	3870	30.8	5000	24.6	1.25
132	3	MA1498.2	HOXA7	MA1498.2	SYMATTAV	HOXA7	2.93e-32	7.67e-35	9050	71.9	13300	65.4	1.1
133	3	MA0715.1	PROP1	MA0715.1	TAATYWAATTA	PROP1	3.53e-32	9.16e-35	4570	36.3	6060	29.8	1.22
134	5	MA0716.1	PRRX1	MA0716.1	YYAATTAR	PRRX1	3.64e-32	9.37e-35	4130	32.8	5380	26.4	1.24
135	5	MA0890.1	GBX2	MA0890.1	RSYAATTARN	GBX2	3.76e-32	9.61e-35	5250	41.7	7110	34.9	1.19
136	3	MA1471.1	BARX2	MA1471.1	NWWAAYMATTAN	BARX2	4.25e-32	1.08e-34	8040	63.9	11600	57	1.12
137	3	MA1497.1	HOXA6	MA1497.1	BGYMATTANN	HOXA6	8.83e-32	2.23e-34	6360	50.5	8870	43.6	1.16
138	14	MA0047.3	FOXA2	MA0047.3	RWGTAAACANN	FOXA2	1.15e-31	2.87e-34	9110	72.4	13400	66	1.1
139	14	MA0851.1	Foxj3	MA0851.1	NDAADGTAAACAAANNM	Foxj3	1.21e-31	3.01e-34	6290	50	8770	43.1	1.16
140	5	MA0125.1	Nobox	MA0125.1	TAATTRSY	Nobox	1.3e-31	3.2e-34	7280	57.8	10400	50.9	1.14
141	13	MA0143.4	SOX2	MA0143.4	DNACAATGGNN	SOX2	1.33e-31	3.26e-34	9730	77.4	14500	71.3	1.09
142	23	MA0711.1	OTX1	MA0711.1	HTAATCCS	OTX1	1.39e-31	3.39e-34	7890	62.7	11400	55.9	1.12
143	6	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	1.58e-31	3.81e-34	5560	44.2	7610	37.4	1.18
144	24	MA1974.1	ZNF211	MA1974.1	HWYATATACCAYRYW	ZNF211	6.46e-31	1.55e-33	5200	41.3	7060	34.7	1.19
145	9	MA0117.2	Mafb	MA0117.2	AWWNTGCTGACD	Mafb	7.71e-31	1.84e-33	8800	69.9	12900	63.5	1.1
146	14	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	8.41e-31	1.99e-33	8580	68.2	12600	61.7	1.11
147	5	MA0642.2	EN2	MA0642.2	VSYAATTA	EN2	9.29e-31	2.18e-33	8290	65.9	12100	59.3	1.11
148	6	MA0480.2	Foxo1	MA0480.2	NDGTAAACANN	Foxo1	1.13e-30	2.63e-33	8890	70.6	13100	64.2	1.1
149	15	MA0037.4	Gata3	MA0037.4	NHTCTTATCTNH	Gata3	1.34e-30	3.11e-33	5700	45.3	7850	38.6	1.17
150	5	MA0879.2	DLX1	MA0879.2	VYAATTAN	DLX1	2.56e-30	5.9e-33	4400	35	5840	28.7	1.22
151	23	MA1480.1	DPRX	MA1480.1	AGATAATCCN	DPRX	2.63e-30	6.01e-33	6070	48.3	8450	41.5	1.16
152	3	MA0912.2	HOXD3	MA0912.2	CTAATTAC	HOXD3	2.84e-30	6.46e-33	3810	30.3	4940	24.3	1.25
153	14	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	2.93e-30	6.62e-33	8870	70.5	13100	64.2	1.1
154	6	MA0891.1	GSC2	MA0891.1	NYTAATCCBH	GSC2	2.99e-30	6.71e-33	8860	70.4	13000	64	1.1
155	6	MA0465.2	CDX2	MA0465.2	NDGCAATAAAWN	CDX2	4.59e-30	1.02e-32	5370	42.7	7340	36.1	1.18
156	18	MA1636.1	CEBPG	MA1636.1	NDATGATGCAATMHH	CEBPG	5.2e-30	1.15e-32	8340	66.2	12200	59.7	1.11
157	25	MA0611.2	Dux	MA0611.2	NTGATTBAATCAVWNN	Dux	5.42e-30	1.19e-32	3660	29.1	4710	23.2	1.26
158	14	MA0481.3	FOXP1	MA0481.3	NDGTAAACANH	FOXP1	5.48e-30	1.2e-32	8100	64.4	11800	57.8	1.11
159	3	MA1500.1	HOXB6	MA1500.1	BTAATKRC	HOXB6	7.16e-30	1.56e-32	10300	81.7	15500	76.2	1.07
160	14	MA1103.2	FOXK2	MA1103.2	DDGTAAACANN	FOXK2	7.23e-30	1.56e-32	7260	57.7	10400	51	1.13
161	26	MA0679.2	ONECUT1	MA0679.2	WAAAAATCAATAAWWN	ONECUT1	8.06e-30	1.73e-32	4590	36.5	6140	30.2	1.21
162	26	MA0755.1	CUX2	MA0755.1	TRATCGATAW	CUX2	8.94e-30	1.9e-32	5760	45.8	7970	39.2	1.17
163	13	MA0514.2	Sox3	MA0514.2	DNACAATGGNN	Sox3	9.06e-30	1.92e-32	9500	75.5	14100	69.5	1.09
164	7	MA0070.1	PBX1	MA0070.1	HCATCAATCAAW	PBX1	1.54e-29	3.25e-32	5180	41.2	7060	34.7	1.19
165	3	MA0707.2	MNX1	MA0707.2	VYRATTAK	MNX1	3.61e-29	7.56e-32	4150	33	5480	26.9	1.23
166	14	MA0031.1	FOXD1	MA0031.1	GTAAACAW	FOXD1	4.53e-29	9.42e-32	6490	51.6	9150	45	1.15
167	5	MA0027.2	EN1	MA0027.2	SYAATTAV	EN1	9.68e-29	2e-31	3490	27.7	4490	22	1.26
168	6	MA0896.1	Hmx1	MA0896.1	VSVAGCAATTAAWGVDB	Hmx1	1.01e-28	2.07e-31	4670	37.1	6280	30.9	1.2
169	12	MA0497.1	MEF2C	MA0497.1	DDDCYAAAAATAGMW	MEF2C	1.02e-28	2.09e-31	6310	50.1	8860	43.5	1.15
170	27	MA0483.1	Gfi1B	MA0483.1	AAATCWCWGCH	Gfi1B	1.07e-28	2.16e-31	5760	45.8	7990	39.3	1.17
171	28	MA1487.2	FOXE1	MA1487.2	VYTAAAYAAACAAH	FOXE1	1.2e-28	2.42e-31	6070	48.3	8490	41.7	1.16
172	29	MA0063.2	NKX2-5	MA0063.2	NNCACTCAANN	NKX2-5	1.7e-28	3.41e-31	8200	65.2	12000	58.8	1.11
173	14	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	2.44e-28	4.87e-31	9330	74.2	13900	68.2	1.09
174	30	MA0523.1	TCF7L2	MA0523.1	DRASATCAAAGRVA	TCF7L2	2.81e-28	5.58e-31	7110	56.5	10200	50	1.13
175	3	MA0888.1	EVX2	MA0888.1	VVTAATTAVB	EVX2	2.95e-28	5.82e-31	4920	39.1	6680	32.8	1.19
176	28	MA0847.3	FOXD2	MA0847.3	SYTAARYAAACA	FOXD2	3.9e-28	7.66e-31	6240	49.6	8770	43.1	1.15
177	10	MA0142.1	Pou5f1::Sox2	MA0142.1	CWTTGTYATGCAAAT	Pou5f1::Sox2	3.97e-28	7.74e-31	4770	37.9	6460	31.7	1.2
178	14	MA1607.1	Foxl2	MA1607.1	DDWATGTAAACANN	Foxl2	5.68e-28	1.1e-30	9430	75	14100	69.1	1.08
179	18	MA0836.2	CEBPD	MA0836.2	NRTTGCACAAYHN	CEBPD	1.24e-27	2.4e-30	9320	74	13900	68.2	1.09
180	1	MA1124.1	ZNF24	MA1124.1	CATTCATTCATTC	ZNF24	2.26e-27	4.33e-30	4820	38.3	6540	32.1	1.19
181	30	MA0769.2	TCF7	MA0769.2	NNCTTTGAWVT	TCF7	4.08e-27	7.79e-30	10100	80.1	15200	74.7	1.07
182	26	MA0754.2	CUX1	MA0754.2	TAATCGATAM	CUX1	4.15e-27	7.87e-30	5710	45.4	7950	39.1	1.16
183	6	MA0648.1	GSC	MA0648.1	VYTAATCCSY	GSC	5.3e-27	1e-29	4350	34.6	5830	28.6	1.21
184	30	MA0768.2	Lef1	MA0768.2	NNBCCTTTGATSTN	Lef1	9.23e-27	1.73e-29	7970	63.3	11600	57.1	1.11
185	6	MA0635.1	BARHL2	MA0635.1	VHTAAAYGRT	BARHL2	1.08e-26	2.02e-29	8680	69	12800	63	1.1
186	6	MA0897.1	Hmx2	MA0897.1	ASAAGCAATTAAHVVRT	Hmx2	2.42e-26	4.49e-29	4860	38.6	6620	32.5	1.19
187	13	MA1563.2	SOX18	MA1563.2	AACAATDV	SOX18	2.45e-26	4.53e-29	8180	65	12000	58.9	1.1
188	15	MA0482.2	GATA4	MA0482.2	NNCCTTATCTNH	GATA4	3.13e-26	5.75e-29	6330	50.3	8960	44	1.14
189	3	MA0658.1	LHX6	MA0658.1	RCTAATTARY	LHX6	3.15e-26	5.76e-29	4040	32.1	5370	26.4	1.22
190	31	MA1657.1	ZNF652	MA1657.1	BAAAGRGTTAAN	ZNF652	3.67e-26	6.66e-29	6280	50	8880	43.6	1.14
191	3	MA0876.1	BSX	MA0876.1	SYVATTAV	BSX	4e-26	7.23e-29	7760	61.7	11300	55.5	1.11
192	17	MA0808.1	TEAD3	MA0808.1	RCATTCCW	TEAD3	4.29e-26	7.71e-29	5460	43.4	7580	37.2	1.17
193	23	MA0714.1	PITX3	MA0714.1	NYTAATCCC	PITX3	5.7e-26	1.02e-28	10100	80	15200	74.8	1.07
194	23	MA0682.2	PITX1	MA0682.2	YTAATCCH	PITX1	6.71e-26	1.19e-28	5480	43.6	7620	37.4	1.16
195	3	MA0914.1	ISL2	MA0914.1	GCAMTTAR	ISL2	6.78e-26	1.2e-28	7820	62.2	11400	56	1.11
196	3	MA0787.1	POU3F2	MA0787.1	WTATGCWAATKA	POU3F2	7.54e-26	1.33e-28	4490	35.7	6060	29.8	1.2
197	3	MA1504.1	HOXC4	MA1504.1	VTMATTAN	HOXC4	9.19e-26	1.61e-28	5240	41.7	7240	35.6	1.17
198	14	MA0850.1	FOXP3	MA0850.1	RTAAACA	FOXP3	9.44e-26	1.65e-28	6730	53.5	9620	47.2	1.13
199	13	MA1120.1	SOX13	MA1120.1	DVACAATGGNN	SOX13	1.48e-25	2.57e-28	10900	86.9	16800	82.4	1.05
200	3	MA0791.1	POU4F3	MA0791.1	RTGMATWATTAATGAR	POU4F3	1.68e-25	2.9e-28	4070	32.4	5430	26.7	1.21
201	32	MA0151.1	Arid3a	MA0151.1	ATYAAA	Arid3a	2.67e-25	4.58e-28	4290	34.1	5770	28.4	1.2
202	33	MA1603.1	Dmrt1	MA1603.1	GHTACAAAGTADC	Dmrt1	7e-25	1.2e-27	8440	67.1	12400	61.2	1.1
203	34	MA1632.1	ATF2	MA1632.1	NNATGABGTCATN	ATF2	7.4e-25	1.26e-27	7810	62.1	11400	56	1.11
204	6	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	8.77e-25	1.48e-27	5710	45.4	8000	39.3	1.15
205	17	MA0090.3	TEAD1	MA0090.3	NNACATTCCAGSN	TEAD1	1.37e-24	2.3e-27	10600	83.9	16100	79.1	1.06
206	9	MA0842.2	NRL	MA0842.2	AAWWNTGCTGACG	NRL	1.61e-24	2.69e-27	2810	22.3	3550	17.4	1.28
207	18	MA0102.4	CEBPA	MA0102.4	NDATTGCACAATHN	CEBPA	1.7e-24	2.84e-27	9460	75.2	14200	69.7	1.08
208	5	MA0666.2	MSX1	MA0666.2	SCAATTAR	MSX1	1.9e-24	3.16e-27	3050	24.3	3910	19.2	1.26
209	22	MA0790.1	POU4F1	MA0790.1	ATGMATAATTAATG	POU4F1	2.13e-24	3.52e-27	3790	30.1	5020	24.7	1.22
210	3	MA0075.3	PRRX2	MA0075.3	CTAATTAN	PRRX2	2.96e-24	4.86e-27	3260	25.9	4230	20.8	1.25
211	14	MA0042.2	FOXI1	MA0042.2	GTAAACA	FOXI1	3.54e-24	5.79e-27	6560	52.2	9380	46.1	1.13
212	5	MA0708.2	MSX2	MA0708.2	SCAATTAV	MSX2	4.65e-24	7.57e-27	3150	25	4060	20	1.25
213	35	MA0788.1 (POU3F3)	STREME-8	8-AGCATA	AGCATA	POU3F3	8.22e-24	1.33e-26	11200	88.6	17200	84.5	1.05
214	13	MA1152.1	SOX15	MA1152.1	CYWTTGTTHW	SOX15	9.84e-24	1.59e-26	10900	86.5	16700	82.1	1.05
215	3	MA0158.2	HOXA5	MA0158.2	GYMATTAS	HOXA5	1.28e-23	2.05e-26	3740	29.7	4960	24.4	1.22
216	36	MA1479.1	DMRTC2	MA1479.1	AATTGMTACATT	DMRTC2	1.3e-23	2.08e-26	8800	69.9	13100	64.3	1.09
217	17	MA1121.1	TEAD2	MA1121.1	NYACATTCCWNNS	TEAD2	2.05e-23	3.26e-26	9070	72.1	13500	66.6	1.08
218	37	MA1150.1	RORB	MA1150.1	AWWTRGGTCAH	RORB	2.39e-23	3.79e-26	9280	73.7	13900	68.3	1.08
219	38	MA1953.1	FOXO1::ELF1	MA1953.1	RTMAACAGGAAGTN	FOXO1::ELF1	4.27e-23	6.73e-26	9720	77.3	14700	72.1	1.07
220	39	MA0144.2	STAT3	MA0144.2	YTTCYKGGAAD	STAT3	4.76e-23	7.46e-26	6910	55	9980	49	1.12
221	3	MA0874.1	Arx	MA0874.1	VTBCRYTAATTARTKSW	Arx	7.47e-23	1.17e-25	3890	30.9	5210	25.6	1.21
222	29	MA1645.1	NKX2-2	MA1645.1	NNNCCACTCAANNN	NKX2-2	9.87e-23	1.53e-25	8120	64.5	12000	58.8	1.1
223	40	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	1.31e-22	2.03e-25	4330	34.4	5890	28.9	1.19
224	14	MA0041.2	FOXD3	MA0041.2	WAWGHAAATAAACARY	FOXD3	1.35e-22	2.09e-25	4410	35.1	6020	29.6	1.19
225	37	MA1151.1	RORC	MA1151.1	NWAWNTRGGTCA	RORC	1.47e-22	2.25e-25	10500	83.8	16100	79.2	1.06
226	30	MA1991.1	Hnf1A	MA1991.1	NBCCTTTGATSTBN	Hnf1A	1.5e-22	2.3e-25	6600	52.4	9470	46.5	1.13
227	3	MA0902.2	HOXB2	MA0902.2	SYAATTAS	HOXB2	2.59e-22	3.94e-25	2510	19.9	3150	15.5	1.29
228	3	MA1505.1	HOXC8	MA1505.1	KTAATTAM	HOXC8	3.05e-22	4.62e-25	3030	24.1	3920	19.3	1.25
229	14	MA0852.2	FOXK1	MA0852.2	NRDGTAAACAAGNN	FOXK1	3.72e-22	5.6e-25	9110	72.4	13600	67	1.08
230	3	MA0612.2	EMX1	MA0612.2	BTAATTAS	EMX1	3.95e-22	5.93e-25	2630	20.9	3330	16.4	1.28
231	18	MA0833.2	ATF4	MA0833.2	DDATGATGCAATMN	ATF4	1.01e-21	1.51e-24	5110	40.6	7120	35	1.16
232	10	MA0627.2	POU2F3	MA0627.2	NWTATGCAAATNH	POU2F3	1.04e-21	1.55e-24	4290	34.1	5850	28.7	1.19
233	3	MA1501.1	HOXB7	MA1501.1	GGTAATTAVS	HOXB7	1.23e-21	1.82e-24	4700	37.4	6490	31.9	1.17
234	41	MA1118.1	SIX1	MA1118.1	GWAACCTGAKM	SIX1	2.11e-21	3.12e-24	10000	79.7	15200	74.9	1.06
235	3	MA0132.2	PDX1	MA0132.2	VYAATTAR	PDX1	2.17e-21	3.19e-24	3220	25.6	4230	20.8	1.23
236	3	MA1499.1	HOXB4	MA1499.1	RTMATTAR	HOXB4	2.23e-21	3.26e-24	5200	41.3	7270	35.7	1.16
237	13	MA0868.2	SOX8	MA0868.2	MGAACAATRG	SOX8	2.63e-21	3.83e-24	10600	84	16200	79.6	1.06
238	38	MA1709.1	ZIM3	MA1709.1	RVMAACAGAAACCYM	ZIM3	3.07e-21	4.45e-24	7550	60	11100	54.4	1.1
239	10	MA0785.1	POU2F1	MA0785.1	AWTATGCWAATK	POU2F1	3.83e-21	5.54e-24	4020	31.9	5440	26.7	1.19
240	42	MA0606.2	Nfat5	MA0606.2	NNATGGAAAAWN	Nfat5	5.62e-21	8.08e-24	8290	65.9	12300	60.4	1.09
241	43	MA1524.2	Msgn1	MA1524.2	VRRRACAAATGGTNNN	Msgn1	9.95e-21	1.43e-23	6760	53.7	9780	48.1	1.12
242	25	MA1720.1	ZNF85	MA1720.1	DHDGAGATTACWKCAK	ZNF85	2.71e-20	3.87e-23	7430	59	10900	53.5	1.1
243	6	MA0898.1	Hmx3	MA0898.1	ASAAGCAATTAAWRRAT	Hmx3	2.73e-20	3.88e-23	3830	30.4	5170	25.4	1.2
244	3	MA1577.1	TLX2	MA1577.1	BYAATTAR	TLX2	3.02e-20	4.28e-23	3130	24.9	4110	20.2	1.23
245	15	MA0140.2	GATA1::TAL1	MA0140.2	MTTATCWSNNNNNHVCAG	GATA1::TAL1	3.24e-20	4.57e-23	3280	26.1	4340	21.4	1.22
246	44	6-CTTTAAA	STREME-6	6-CTTTAAA	CTTTAAA	CTTTAAA	3.86e-20	5.42e-23	5340	42.5	7530	37	1.15
247	34	MA1126.1	FOS::JUN	MA1126.1	DRTGACGTCATHNDTN	FOS::JUN	3.97e-20	5.54e-23	5680	45.2	8070	39.7	1.14
248	21	MA0907.1	HOXC13	MA0907.1	BCTCGTAAAAH	HOXC13	6.21e-20	8.65e-23	4910	39.1	6860	33.7	1.16
249	45	MA1112.2	NR4A1	MA1112.2	NNAAAGGTCANN	NR4A1	6.78e-20	9.4e-23	9350	74.3	14100	69.3	1.07
250	46	MA1588.1	ZNF136	MA1588.1	RWATTCTTGGTTGRC	ZNF136	6.91e-20	9.54e-23	4520	35.9	6240	30.7	1.17
251	47	MA0631.1	Six3	MA0631.1	DATRGGGTATCAYNWNT	Six3	7.74e-20	1.06e-22	5120	40.7	7190	35.3	1.15
252	23	MA0467.2	Crx	MA0467.2	NDGGATTANN	Crx	8.41e-20	1.15e-22	7340	58.4	10800	52.8	1.1
253	41	MA1119.1	SIX2	MA1119.1	NNCTGAAACCTGATMY	SIX2	1.43e-19	1.95e-22	8030	63.8	11900	58.4	1.09
254	3	MA0895.1	HMBOX1	MA0895.1	MYTAGTTAMS	HMBOX1	1.54e-19	2.1e-22	7170	57	10500	51.5	1.11
255	36	MA1707.1	DMRTA1	MA1707.1	AWTTGWTACAWT	DMRTA1	1.55e-19	2.1e-22	7870	62.6	11600	57.2	1.09
256	21	MA0908.1	HOXD11	MA0908.1	RTCGTAAAAH	HOXD11	1.6e-19	2.16e-22	4310	34.3	5940	29.2	1.18
257	3	MA0893.2	GSX2	MA0893.2	SYMATTAR	GSX2	2.87e-19	3.85e-22	11100	87.9	17100	84	1.05
258	3	MA0724.1	VENTX	MA0724.1	AMCGATTAR	VENTX	2.96e-19	3.95e-22	2580	20.5	3320	16.3	1.26
259	23	MA0883.1	Dmbx1	MA0883.1	WDRWNMGGATTADKNNW	Dmbx1	4.14e-19	5.52e-22	4370	34.7	6030	29.6	1.17
260	3	MA1507.1	HOXD4	MA1507.1	VTMATTAD	HOXD4	4.53e-19	6.02e-22	3590	28.6	4840	23.8	1.2
261	6	MA0124.2	Nkx3-1	MA0124.2	RCCACTTAA	Nkx3-1	8.17e-19	1.08e-21	8620	68.5	12900	63.4	1.08
262	34	MA0018.4	CREB1	MA0018.4	NNRTGATGTCAYN	CREB1	1.54e-18	2.03e-21	10700	85.2	16500	81.2	1.05
263	10	MA1962.1	POU2F1::SOX2	MA1962.1	MATTTRCATMACAATRG	POU2F1::SOX2	1.97e-18	2.58e-21	2970	23.6	3910	19.2	1.23
264	29	MA1523.1	MSANTD3	MA1523.1	STVCACTCAC	MSANTD3	1.98e-18	2.59e-21	9140	72.6	13800	67.7	1.07
265	48	MA0629.1	Rhox11	MA0629.1	ANKNCGCTGTWAWDVRW	Rhox11	1.99e-18	2.59e-21	8960	71.2	13500	66.3	1.07
266	43	MA1618.1	Ptf1a	MA1618.1	NNACAGATGTTNN	Ptf1a	2.28e-18	2.96e-21	10000	79.7	15300	75.2	1.06
267	3	MA0875.1	BARX1	MA0875.1	VCMATTAV	BARX1	2.94e-18	3.8e-21	2300	18.3	2920	14.3	1.27
268	34	MA1127.1	FOSB::JUN	MA1127.1	GATGACGTCAT	FOSB::JUN	3.84e-18	4.94e-21	8650	68.7	13000	63.7	1.08
269	43	MA0093.3	USF1	MA0093.3	NDGTCATGTGACHN	USF1	4.26e-18	5.47e-21	9880	78.6	15100	74	1.06
270	34	MA1131.1	FOSL2::JUN	MA1131.1	GRTGACGTMAT	FOSL2::JUN	4.46e-18	5.7e-21	8420	66.9	12600	61.9	1.08
271	22	MA0046.2	HNF1A	MA0046.2	DRTTAATNATTAACN	HNF1A	4.85e-18	6.18e-21	2570	20.5	3330	16.4	1.25
272	3	MA0618.1	LBX1	MA0618.1	TTAATTAG	LBX1	5.32e-18	6.75e-21	5180	41.2	7340	36	1.14
273	45	MA0693.3	Vdr	MA0693.3	NNGAGTTCANN	Vdr	6.94e-18	8.77e-21	9310	74	14100	69.2	1.07
274	10	MA0786.1	POU3F1	MA0786.1	WTATGCWAATKW	POU3F1	1.08e-17	1.36e-20	3400	27	4580	22.5	1.2
275	14	MA0613.1	FOXG1	MA0613.1	RTAAACAW	FOXG1	1.8e-17	2.26e-20	3830	30.5	5250	25.8	1.18
276	49	MA0050.3	Irf1	MA0050.3	ANTGAAACTGAAASH	Irf1	2.02e-17	2.53e-20	9660	76.8	14700	72.2	1.06
277	23	MA0719.1	RHOXF1	MA0719.1	NTRATCCN	RHOXF1	2.04e-17	2.54e-20	8450	67.2	12700	62.2	1.08
278	5	MA0894.1	HESX1	MA0894.1	GHTAATTRRH	HESX1	2.82e-17	3.5e-20	2870	22.8	3780	18.6	1.23
279	43	MA1123.2	TWIST1	MA1123.2	NNDCCAGATGTBN	TWIST1	3.34e-17	4.14e-20	9620	76.5	14600	72	1.06
280	30	MA0442.2	SOX10	MA0442.2	NDAACAAAGVN	SOX10	4.41e-17	5.44e-20	8670	68.9	13000	64	1.08
281	43	MA0620.3	MITF	MA0620.3	NNNDRTCACGTGAYHNNN	MITF	8.57e-17	1.05e-19	6880	54.7	10100	49.6	1.1
282	3	MA1496.1	HOXA4	MA1496.1	RTMATTAV	HOXA4	1.1e-16	1.35e-19	4540	36.1	6370	31.3	1.15
283	14	MA0849.1	FOXO6	MA0849.1	GTAAACA	FOXO6	1.19e-16	1.46e-19	6400	50.8	9310	45.7	1.11
284	13	MA0867.2	SOX4	MA0867.2	RAACAAAGRV	SOX4	1.33e-16	1.62e-19	7160	56.9	10600	51.9	1.1
285	39	MA1624.1	Stat5a	MA1624.1	NTTCCAAGAANH	Stat5a	1.64e-16	1.99e-19	9700	77.1	14800	72.7	1.06
286	50	MA1593.1	ZNF317	MA1593.1	WVACAGCAGAYW	ZNF317	3.97e-16	4.79e-19	10600	84	16300	80.1	1.05
287	38	MA1105.2	GRHL2	MA1105.2	NRAACAGGTTYN	GRHL2	6.5e-16	7.82e-19	11000	87.2	17000	83.7	1.04
288	51	MA1980.1	ZNF418	MA1980.1	MDGAGGCTAAAAGCA	ZNF418	6.6e-16	7.92e-19	6560	52.2	9600	47.2	1.11
289	18	MA0043.3	HLF	MA0043.3	NNRTTATGCAACHN	HLF	6.86e-16	8.19e-19	4080	32.4	5680	27.9	1.16
290	38	MA1623.1	Stat2	MA1623.1	RGAAACAGAAASH	Stat2	1.3e-15	1.54e-18	9550	75.9	14600	71.6	1.06
291	6	MA0913.2	HOXD9	MA0913.2	GYMATAAAAH	HOXD9	1.67e-15	1.98e-18	3540	28.1	4840	23.8	1.18
292	40	MA0774.1	MEIS2	MA0774.1	TTGACAGS	MEIS2	1.91e-15	2.26e-18	7130	56.7	10500	51.8	1.09
293	36	MA1478.1	DMRTA2	MA1478.1	AATTGHTACAWT	DMRTA2	2.4e-15	2.83e-18	8460	67.2	12700	62.5	1.07
294	3	MA0705.1	Lhx8	MA0705.1	CTAATTAV	Lhx8	2.55e-15	2.99e-18	2620	20.9	3470	17	1.22
295	29	MA1114.1	PBX3	MA1114.1	NNNTGAGTGACAGGBNN	PBX3	2.59e-15	3.03e-18	10900	86.9	17000	83.4	1.04
296	52	MA0780.1	PAX3	MA0780.1	TAATYRATTA	PAX3	3.01e-15	3.51e-18	2710	21.5	3590	17.6	1.22
297	53	MA0092.1	Hand1::Tcf3	MA0092.1	BRTCTGGMWT	Hand1::Tcf3	4.58e-15	5.33e-18	11100	87.9	17200	84.6	1.04
298	43	MA0827.1	OLIG3	MA0827.1	AMCATATGBY	OLIG3	4.91e-15	5.69e-18	9210	73.2	14000	68.8	1.06
299	54	MA0800.1	EOMES	MA0800.1	RAGGTGTGAAAWN	EOMES	8.94e-15	1.03e-17	7170	57	10600	52.2	1.09
300	43	MA0095.3	Yy1	MA0095.3	NNCAAAATGGCN	Yy1	8.96e-15	1.03e-17	11400	90.5	17800	87.4	1.03
301	39	MA1625.1	Stat5b	MA1625.1	NNNTTCCCAGAANNN	Stat5b	9.01e-15	1.03e-17	9440	75	14400	70.7	1.06
302	55	MA1975.1	ZNF214	MA1975.1	VWTCATCAABGTCCT	ZNF214	9.88e-15	1.13e-17	5560	44.2	8020	39.4	1.12
303	56	MA1125.1	ZNF384	MA1125.1	DNWMAAAAAAAA	ZNF384	1.02e-14	1.16e-17	4450	35.3	6270	30.8	1.15
304	40	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	1.43e-14	1.63e-17	3860	30.6	5360	26.3	1.16
305	26	MA0757.1	ONECUT3	MA0757.1	AAAAAATCRATAAH	ONECUT3	2e-14	2.27e-17	3320	26.4	4540	22.3	1.18
306	34	MA1139.1	FOSL2::JUNB	MA1139.1	DATGACGTCATH	FOSL2::JUNB	2.88e-14	3.25e-17	6300	50.1	9220	45.3	1.1
307	57	MA0069.1	PAX6	MA0069.1	TTCACGCWTSANTK	PAX6	1.48e-13	1.66e-16	4670	37.1	6660	32.7	1.13
308	34	MA1145.1	FOSL2::JUND	MA1145.1	NNRTGACGTCAYHSN	FOSL2::JUND	1.67e-13	1.87e-16	6920	55	10300	50.4	1.09
309	3	MA0702.2	LMX1A	MA0702.2	TTAATTAM	LMX1A	2.54e-13	2.83e-16	2710	21.6	3640	17.9	1.2
310	14	MA0614.1	Foxj2	MA0614.1	RTAAACAA	Foxj2	3.01e-13	3.35e-16	2980	23.7	4050	19.9	1.19
311	21	MA0911.1	Hoxa11	MA0911.1	RGTCGTAAAANT	Hoxa11	3.22e-13	3.57e-16	4000	31.8	5620	27.6	1.15
312	43	MA0461.2	Atoh1	MA0461.2	RMCATATGBY	Atoh1	4e-13	4.43e-16	10100	80.4	15600	76.7	1.05
313	34	MA1129.1	FOSL1::JUN	MA1129.1	ATGACGTCAT	FOSL1::JUN	6.06e-13	6.68e-16	8590	68.2	13000	64	1.07
314	34	MA1143.1	FOSL1::JUND	MA1143.1	RTGACGTMAY	FOSL1::JUND	1.06e-12	1.16e-15	10100	80.5	15600	76.8	1.05
315	38	MA0743.2	SCRT1	MA0743.2	NDWKCAACAGGTGKNN	SCRT1	3.07e-12	3.36e-15	9630	76.5	14800	72.7	1.05
316	58	MA0877.3	BARHL1	MA0877.3	AMCGTTTA	BARHL1	3.66e-12	4e-15	6990	55.6	10400	51.2	1.09
317	42	MA0624.2	Nfatc1	MA0624.2	NVATGGAAAAWN	Nfatc1	4.72e-12	5.14e-15	10500	83.5	16300	80.1	1.04
318	38	MA0744.2	SCRT2	MA0744.2	NNWGCAACAGGTGDNN	SCRT2	7.9e-12	8.58e-15	10800	85.9	16800	82.8	1.04
319	40	MA0775.1	MEIS3	MA0775.1	DTGACAGS	MEIS3	8.6e-12	9.31e-15	2240	17.8	2970	14.6	1.22
320	59	MA0124.2 (Nkx3-1)	STREME-9	9-TTAAGT	TTAAGT	Nkx3-1	9.73e-12	1.05e-14	2210	17.6	2930	14.4	1.22
321	60	YWWRAAAWTRKTTTT	MEME-6	YWWRAAAWTRKTTTT	YWWRAAAWTRKTTTT	YWWRAAAWTRKTTTT	1.38e-11	1.48e-14	1760	14	2260	11.1	1.26
322	61	MA1977.1	ZNF324	MA1977.1	NNNWRGMAGHYAAGGATGGTT	ZNF324	2.07e-11	2.21e-14	6660	52.9	9900	48.6	1.09
323	12	MA0773.1	MEF2D	MA0773.1	DCTAWAAATAGM	MEF2D	2.27e-11	2.43e-14	1160	9.23	1410	6.91	1.33
324	3	MA0621.1	mix-a	MA0621.1	NDTTAATTAGN	mix-a	2.49e-11	2.66e-14	1780	14.1	2300	11.3	1.25
325	37	MA1148.1	PPARA::RXRA	MA1148.1	AWNTRGGTYAAAGGTCAN	PPARA::RXRA	3.08e-11	3.27e-14	7000	55.6	10500	51.4	1.08
326	54	MA1567.2	Tbx6	MA1567.2	NRGGTGTGAANN	Tbx6	4.98e-11	5.28e-14	8960	71.2	13700	67.3	1.06
327	62	MA1984.1	ZNF667	MA1984.1	TTAAGAGCTCAV	ZNF667	5.31e-11	5.61e-14	7780	61.9	11800	57.7	1.07
328	43	MA0678.1	OLIG2	MA0678.1	AMCATATGKT	OLIG2	6.53e-11	6.87e-14	3660	29.1	5160	25.4	1.15
329	45	MA1540.2	NR5A1	MA1540.2	NNRAGTTCAAGGTCANN	NR5A1	7.16e-11	7.52e-14	10400	82.6	16100	79.3	1.04
330	63	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	7.78e-11	8.15e-14	4310	34.2	6170	30.3	1.13
331	64	MA1579.1	ZBTB26	MA1579.1	NNCTCCAGAAANNNN	ZBTB26	8.49e-11	8.86e-14	9910	78.8	15300	75.3	1.05
332	65	MA0521.2 (Tcf12)	STREME-5	5-WYAGCTRW	WYAGCTRW	Tcf12	1.16e-10	1.2e-13	1850	14.7	2420	11.9	1.24
333	45	MA0592.3	ESRRA	MA0592.3	NBTCAAGGTCAHN	ESRRA	1.17e-10	1.21e-13	7010	55.7	10500	51.6	1.08
334	37	MA0258.2	ESR2	MA0258.2	AGGTCASVNTGMCCY	ESR2	1.61e-10	1.66e-13	9900	78.7	15300	75.2	1.05
335	21	MA0594.2	HOXA9	MA0594.2	RTCGTWAHNN	HOXA9	1.7e-10	1.76e-13	9350	74.3	14400	70.6	1.05
336	39	MA0518.1	Stat4	MA0518.1	YTTCYRGGAARNVR	Stat4	2.01e-10	2.07e-13	5930	47.2	8760	43.1	1.09
337	34	MA1136.1	FOSB::JUNB	MA1136.1	RTGACGTCAT	FOSB::JUNB	2.49e-10	2.55e-13	9380	74.6	14400	70.9	1.05
338	34	MA0488.1	JUN	MA0488.1	DDRATGATGTCAT	JUN	2.61e-10	2.67e-13	1810	14.4	2370	11.7	1.24
339	34	MA0596.1	SREBF2	MA0596.1	RTGGGGTGAY	SREBF2	2.98e-10	3.04e-13	2680	21.3	3680	18.1	1.18
340	42	MA0152.2	Nfatc2	MA0152.2	NNRNAATGGAAANWNH	Nfatc2	3.34e-10	3.39e-13	11000	87.5	17200	84.7	1.03
341	34	MA0829.2	SREBF1	MA0829.2	DNATCACSTGATNH	SREBF1	3.74e-10	3.79e-13	7430	59	11200	55	1.07
342	66	MA1647.2	Prdm4	MA1647.2	RDNCCTTGAAACYGYYN	Prdm4	3.89e-10	3.92e-13	7710	61.3	11700	57.3	1.07
343	12	MA0660.1	MEF2B	MA0660.1	RCTAWAAATAGC	MEF2B	5.14e-10	5.17e-13	1150	9.16	1420	6.98	1.31
344	67	MA1729.1	ZNF680	MA1729.1	GNCCAAGAAGAATDA	ZNF680	5.79e-10	5.81e-13	3610	28.7	5110	25.1	1.14
345	39	MA0137.3	STAT1	MA0137.3	TTTCYRGGAAA	STAT1	6.66e-10	6.66e-13	5010	39.8	7320	36	1.11
346	3	MA0135.1	Lhx3	MA0135.1	WAATTAATTAWYY	Lhx3	6.74e-10	6.71e-13	1910	15.2	2530	12.4	1.22
347	54	MA0802.1	TBR1	MA0802.1	AGGTGTGAAA	TBR1	6.75e-10	6.71e-13	7420	58.9	11200	55	1.07
348	68	MA0502.2	NFYB	MA0502.2	CYCATTGGCCVV	NFYB	9.36e-10	9.29e-13	3580	28.5	5080	25	1.14
349	39	MA0463.2	BCL6	MA0463.2	NYGCTTTCKAGGAAYN	BCL6	1.26e-09	1.25e-12	6760	53.7	10100	49.8	1.08
350	3	MA0683.1	POU4F2	MA0683.1	RTGCATAATTAATGAG	POU4F2	1.4e-09	1.38e-12	1350	10.8	1720	8.43	1.28
351	69	MA1995.1	Npas4	MA1995.1	NNTCGTGACHN	Npas4	1.47e-09	1.45e-12	10000	79.6	15500	76.4	1.04
352	30	MA0869.2	Sox11	MA0869.2	NRGAACAAAGVV	Sox11	1.76e-09	1.73e-12	8030	63.8	12200	60	1.06
353	39	MA0519.1	Stat5a::Stat5b	MA0519.1	DTTTCCMAGAA	Stat5a::Stat5b	1.77e-09	1.73e-12	5190	41.2	7610	37.4	1.1
354	17	MA0114.4	HNF4A	MA0114.4	DNCAAAGTCCANN	HNF4A	2.14e-09	2.09e-12	6120	48.6	9100	44.7	1.09
355	66	MA1724.1	Rfx6	MA1724.1	HNCCTAGCAACHV	Rfx6	2.46e-09	2.39e-12	7400	58.8	11200	55	1.07
356	70	TYTCTCYYTCT	MEME-5	TYTCTCYYTCT	TYTCTCYYTCT	TYTCTCYYTCT	3.87e-09	3.76e-12	3370	26.8	4780	23.5	1.14
357	1	MA0591.1	Bach1::Mafk	MA0591.1	RSSATGACTCAGCAB	Bach1::Mafk	4e-09	3.87e-12	2610	20.7	3600	17.7	1.17
358	13	MA1561.1	SOX12	MA1561.1	ACCGAACAATV	SOX12	5.21e-09	5.03e-12	4320	34.3	6250	30.7	1.12
359	71	MA1534.1	NR1I3	MA1534.1	RTGAACTTT	NR1I3	5.29e-09	5.09e-12	8530	67.8	13100	64.2	1.06
360	37	MA0494.1	Nr1h3::Rxra	MA0494.1	TGACCTNNAGTRACCYYDN	Nr1h3::Rxra	5.47e-09	5.24e-12	5280	42	7780	38.2	1.1
361	34	MA0492.1	JUND	MA0492.1	DDDRATGABGTCATN	JUND	6.49e-09	6.21e-12	1900	15.1	2540	12.5	1.21
362	3	MA0884.2	DUXA	MA0884.2	YTRATTWAATYAR	DUXA	7.88e-09	7.52e-12	1680	13.4	2220	10.9	1.23
363	17	MA0484.2	HNF4G	MA0484.2	DNCAAAGTCCANN	HNF4G	9.69e-09	9.22e-12	6890	54.8	10400	51	1.07
364	72	MA0671.1	NFIX	MA0671.1	NNTGCCAAN	NFIX	1.02e-08	9.71e-12	7560	60	11500	56.3	1.07
365	25	MA0468.1	DUX4	MA0468.1	TAAYYYAATCA	DUX4	1.55e-08	1.46e-11	1640	13	2160	10.6	1.23
366	41	MA2001.1	Six4	MA2001.1	GDAACCTGANH	Six4	1.66e-08	1.56e-11	11400	90.8	18000	88.6	1.03
367	29	MA1994.1	Nkx2-1	MA1994.1	NVCACTTGARHNN	Nkx2-1	2.07e-08	1.95e-11	10900	86.7	17100	84.1	1.03
368	73	MA0508.3	PRDM1	MA0508.3	YNCTTTCTCTH	PRDM1	2.56e-08	2.41e-11	8920	70.9	13700	67.4	1.05
369	34	MA1133.1	JUN::JUNB	MA1133.1	KRTGACGTCATN	JUN::JUNB	2.95e-08	2.76e-11	11300	90.2	17900	87.8	1.03
370	74	MA1714.1	ZNF675	MA1714.1	RGGVHYMGGAGGMCAAAATGD	ZNF675	3.15e-08	2.94e-11	4950	39.3	7280	35.8	1.1
371	28	MA0040.1	Foxq1	MA0040.1	HATTGTTTATW	Foxq1	3.24e-08	3.01e-11	2030	16.1	2750	13.5	1.19
372	1	MA1520.1	MAF	MA1520.1	NTGCTGASTCAGCAH	MAF	4.3e-08	4e-11	6170	49.1	9240	45.4	1.08
373	15	MA0029.1	Mecom	MA0029.1	AAGAYAAGATAANA	Mecom	4.75e-08	4.4e-11	945	7.51	1160	5.7	1.32
374	14	MA0593.1	FOXP2	MA0593.1	RWGTAAACAVR	FOXP2	5.46e-08	5.04e-11	2330	18.5	3200	15.7	1.17
375	75	MA1989.1	Bcl11B	MA1989.1	NNAAACCACAARNN	Bcl11B	6.4e-08	5.89e-11	11700	93.2	18600	91.2	1.02
376	27	MA0038.2	GFI1	MA0038.2	BMAATCACDGCA	GFI1	7.14e-08	6.56e-11	1320	10.5	1710	8.39	1.25
377	72	MA0161.2	NFIC	MA0161.2	NNCTTGGCANN	NFIC	7.46e-08	6.83e-11	7920	62.9	12100	59.4	1.06
378	3	MA1960.1	MGA::EVX1	MA1960.1	RGGTGWTAATKD	MGA::EVX1	8.77e-08	8.01e-11	2040	16.2	2780	13.7	1.19
379	38	MA1952.1	FOXJ2::ELF1	MA1952.1	RTAAACMGGAAGTR	FOXJ2::ELF1	9.15e-08	8.33e-11	10300	82	16100	79.1	1.04
380	38	MA1950.1	FLI1::FOXI1	MA1950.1	RTAAACAGGAARYN	FLI1::FOXI1	9.71e-08	8.82e-11	9260	73.6	14300	70.4	1.05
381	21	MA0906.1	HOXC12	MA0906.1	RGTCGTAAAAH	HOXC12	1.03e-07	9.3e-11	2370	18.8	3280	16.1	1.17
382	75	MA0002.2	Runx1	MA0002.2	BBYTGTGGTTT	Runx1	1.58e-07	1.43e-10	11500	91.2	18100	89	1.02
383	76	MA0797.1	TGIF2	MA0797.1	TGACAGSTGTCA	TGIF2	1.73e-07	1.56e-10	3010	23.9	4270	21	1.14
384	13	MA0087.2	Sox5	MA0087.2	VRVAACAATGGNN	Sox5	2.27e-07	2.05e-10	2220	17.6	3060	15	1.17
385	38	MA0081.2	SPIB	MA0081.2	TYTCACTTCCTCTTTY	SPIB	2.74e-07	2.46e-10	10300	81.9	16100	79.2	1.04
386	43	MA1108.2	MXI1	MA1108.2	NNCACATGBN	MXI1	4.45e-07	3.98e-10	6530	51.9	9850	48.4	1.07
387	77	MA0878.3	CDX1	MA0878.3	GGYMATAAAA	CDX1	5.92e-07	5.28e-10	1500	12	2000	9.82	1.22
388	43	MA1109.1	NEUROD1	MA1109.1	NRACAGATGGYNN	NEUROD1	1.08e-06	9.62e-10	9900	78.7	15400	75.8	1.04
389	34	MA0595.1	SREBF1	MA0595.1	VTCACCCCAY	SREBF1	1.7e-06	1.51e-09	2440	19.4	3430	16.8	1.15
390	34	MA0684.2	RUNX3	MA0684.2	NHAACCTCAANN	RUNX3	2.42e-06	2.14e-09	11200	88.8	17600	86.6	1.03
391	18	MA0639.1	DBP	MA0639.1	NRTTACGTAAYV	DBP	2.86e-06	2.52e-09	2310	18.3	3230	15.9	1.16
392	78	MA1580.1	ZBTB32	MA1580.1	TGTACAGTAW	ZBTB32	3.02e-06	2.66e-09	2570	20.4	3630	17.8	1.14
393	38	MA1954.1	FOXO1::ELK1	MA1954.1	RWMAACAGGAAGTD	FOXO1::ELK1	3.74e-06	3.29e-09	8600	68.4	13300	65.3	1.05
394	79	MA1998.1	Prdm14	MA1998.1	NDGGTCTCTAWS	Prdm14	4.04e-06	3.54e-09	8800	69.9	13600	66.9	1.05
395	80	MA1968.1	TFCP2	MA1968.1	AAACCGGTTY	TFCP2	8.12e-06	7.1e-09	9060	72	14100	69.1	1.04
396	3	MA1949.1	FLI1::DRGX	MA1949.1	ACCGGAAGTAATTAT	FLI1::DRGX	8.76e-06	7.64e-09	8500	67.6	13100	64.6	1.05
397	29	MA0673.1	NKX2-8	MA0673.1	VCACTTSAV	NKX2-8	8.81e-06	7.66e-09	10900	86.4	17100	84.1	1.03
398	10	MA0784.2	POU1F1	MA0784.2	ANCTMATTWGCATAWT	POU1F1	9.46e-06	8.21e-09	1290	10.2	1710	8.4	1.22
399	38	MA1955.1	FOXO1::ELK3	MA1955.1	RWMAACAGGAAGTN	FOXO1::ELK3	1.04e-05	9.03e-09	6150	48.8	9300	45.7	1.07
400	45	MA0160.2	NR4A2	MA0160.2	BWAAAGGTCA	NR4A2	1.12e-05	9.68e-09	5460	43.4	8200	40.3	1.08
401	54	MA0689.1	TBX20	MA0689.1	WAGGTGTGAAR	TBX20	1.22e-05	1.05e-08	3200	25.5	4640	22.8	1.12
402	45	MA0065.2	Pparg::Rxra	MA0065.2	STRGGGCARAGGKCA	Pparg::Rxra	1.91e-05	1.64e-08	5380	42.8	8080	39.7	1.08
403	81	MA0770.1	HSF2	MA0770.1	TTCTAGAAYRTTC	HSF2	2.03e-05	1.74e-08	3280	26.1	4760	23.4	1.11
404	38	MA1508.1	IKZF1	MA1508.1	VVAACAGGAARN	IKZF1	2.18e-05	1.86e-08	7200	57.2	11000	54.2	1.06
405	34	MA0609.2	CREM	MA0609.2	NNDGTGACGTCACHNN	CREM	2.24e-05	1.91e-08	10700	85.3	16900	83.1	1.03
406	82	MA0520.1	Stat6	MA0520.1	BDBTTCCWSAGAAVY	Stat6	2.56e-05	2.18e-08	2940	23.4	4240	20.8	1.12
407	3	MA1546.1	PAX3	MA1546.1	YSGTCACGSYWATTAN	PAX3	2.82e-05	2.39e-08	5370	42.7	8070	39.7	1.08
408	43	MA0668.2	Neurod2	MA0668.2	NNGRACAGATGGYNN	Neurod2	2.89e-05	2.45e-08	10200	80.7	15900	78.2	1.03
409	76	MA0667.1	MYF6	MA0667.1	AACARCTGTT	MYF6	3.62e-05	3.06e-08	2480	19.7	3530	17.3	1.14
410	28	MA0030.1	FOXF2	MA0030.1	BNAASGTAAACAAD	FOXF2	6.27e-05	5.28e-08	1490	11.8	2030	9.95	1.19
411	83	MA0019.1	Ddit3::Cebpa	MA0019.1	VNRTGCAATMCC	Ddit3::Cebpa	8.14e-05	6.84e-08	7720	61.3	11900	58.4	1.05
412	29	MA2003.1	NKX2-4	MA2003.1	CCACTTSAVV	NKX2-4	8.36e-05	7.01e-08	10500	83.4	16500	81.1	1.03
413	43	MA1651.1	ZFP42	MA1651.1	NNNHCAARATGGCTGCCNBNN	ZFP42	8.65e-05	7.23e-08	7520	59.7	11600	56.8	1.05
414	43	MA1467.2	Atoh1	MA1467.2	RVCAGATGGYN	Atoh1	0.000112	9.31e-08	11600	92.3	18400	90.6	1.02
415	84	MA1983.1	ZNF582	MA1983.1	TCTGTTACTTGCAGCCAAAWG	ZNF582	0.00012	9.95e-08	2390	19	3410	16.8	1.13
416	45	MA0643.1	Esrrg	MA0643.1	TCAAGGTCAH	Esrrg	0.000123	1.02e-07	4000	31.8	5920	29.1	1.09
417	38	MA0080.6	Spi1	MA0080.6	RRAAAGAGGAAGTGGDD	Spi1	0.000134	1.11e-07	9140	72.6	14200	70	1.04
418	77	MA1473.1	CDX4	MA1473.1	GGYMATAAAAC	CDX4	0.000158	1.31e-07	997	7.92	1310	6.44	1.23
419	37	MA0072.1	RORA	MA0072.1	NWWAWBTAGGTCAR	RORA	0.000185	1.52e-07	771	6.13	982	4.82	1.27
420	43	MA1570.1	TFAP4	MA1570.1	AHCATRTGDT	TFAP4	0.000222	1.83e-07	2500	19.9	3590	17.6	1.13
421	43	MA1642.1	NEUROG2	MA1642.1	NNVACAGATGGNN	NEUROG2	0.000226	1.86e-07	11100	88.5	17600	86.6	1.02
422	43	MA0698.1	ZBTB18	MA0698.1	NATCCAGATGTKB	ZBTB18	0.000246	2.01e-07	2750	21.9	3980	19.6	1.12
423	43	MA0607.2	BHLHA15	MA0607.2	ACCATATGGT	BHLHA15	0.000255	2.08e-07	2620	20.8	3780	18.6	1.12
424	36	MA0610.1	DMRT3	MA0610.1	MATGTATCAAN	DMRT3	0.00033	2.68e-07	1920	15.3	2710	13.3	1.15
425	80	MA0647.1	GRHL1	MA0647.1	AAAACCGGTTTD	GRHL1	0.000409	3.32e-07	3680	29.3	5450	26.8	1.09
426	37	MA1111.1	NR2F2	MA1111.1	NAAAGGTCANR	NR2F2	0.000488	3.96e-07	1760	14	2480	12.2	1.15
427	65	MA0691.1	TFAP4	MA0691.1	AWCAGCTGWT	TFAP4	0.000599	4.84e-07	924	7.34	1220	5.98	1.23
428	29	MA0672.1	NKX2-3	MA0672.1	VCCACTTRAV	NKX2-3	0.000615	4.96e-07	10700	85	16900	83	1.02
429	54	MA1565.1	TBX18	MA1565.1	DRAGGTGTGAAR	TBX18	0.000632	5.09e-07	5880	46.7	8950	44	1.06
430	85	MA0619.1	LIN54	MA0619.1	DTTTRAATH	LIN54	0.000696	5.59e-07	1730	13.8	2430	11.9	1.15
431	34	MA1996.1	Nr1H2	MA1996.1	NNRAGGTCANN	Nr1H2	0.000704	5.64e-07	10500	83.5	16600	81.4	1.03
432	45	MA0141.3	ESRRB	MA0141.3	TCAAGGTCAWW	ESRRB	0.000885	7.08e-07	1210	9.63	1650	8.1	1.19
433	45	MA1541.1	NR6A1	MA1541.1	NYCAAGKTCAAGKTCAN	NR6A1	0.0012	9.56e-07	5920	47	9030	44.4	1.06
434	23	MA1547.2	PITX2	MA1547.2	YTAATCCY	PITX2	0.00136	1.08e-06	1210	9.64	1660	8.14	1.19
435	86	MA0106.3	TP53	MA0106.3	RACATGYCCGGRCATGTY	TP53	0.0014	1.11e-06	1310	10.4	1800	8.84	1.18
436	76	MA1572.1	TGIF2LY	MA1572.1	TGACAGCTGTCA	TGIF2LY	0.00149	1.18e-06	2760	22	4030	19.8	1.11
437	72	MA1528.1	NFIX	MA1528.1	STTGGCRNNGTGCCARB	NFIX	0.00211	1.66e-06	799	6.35	1050	5.14	1.23
438	5	MA0479.1	FOXH1	MA0479.1	BNSAATCCACA	FOXH1	0.00211	1.66e-06	616	4.9	781	3.84	1.28
439	39	MA1116.1	RBPJ	MA1116.1	BVTGGGAANN	RBPJ	0.00212	1.67e-06	9640	76.7	15100	74.4	1.03
440	54	MA0688.1	TBX2	MA0688.1	DAGGTGTGAAA	TBX2	0.00222	1.74e-06	3010	23.9	4430	21.8	1.1
441	54	MA0803.1	TBX15	MA0803.1	AGGTGTGA	TBX15	0.00262	2.05e-06	1440	11.4	2000	9.83	1.16
442	43	MA1638.1	HAND2	MA1638.1	NVCAGATGNN	HAND2	0.00328	2.56e-06	9590	76.2	15100	74	1.03
443	54	MA0801.1	MGA	MA0801.1	AGGTGTGA	MGA	0.00334	2.61e-06	4300	34.2	6460	31.8	1.08
444	38	MA1937.1	ERF::HOXB13	MA1937.1	VSCGGAARYNRTWAAN	ERF::HOXB13	0.00353	2.74e-06	6940	55.2	10700	52.7	1.05
445	72	MA0119.1	NFIC::TLX1	MA0119.1	TGGCASSRWGCCAA	NFIC::TLX1	0.00464	3.6e-06	768	6.1	1010	4.96	1.23
446	37	MA0071.1	RORA	MA0071.1	AWMWAGGTCA	RORA	0.00511	3.95e-06	3380	26.8	5020	24.7	1.09
447	37	MA0677.1	Nr2f6	MA0677.1	RRGGTCAAAGGTCA	Nr2f6	0.00545	4.21e-06	5540	44	8450	41.5	1.06
448	54	MA0805.1	TBX1	MA0805.1	AGGTGTGA	TBX1	0.00585	4.5e-06	2000	15.9	2870	14.1	1.13
449	43	MA0818.2	BHLHE22	MA0818.2	AMCATATGKY	BHLHE22	0.00585	4.5e-06	1640	13	2320	11.4	1.14
450	45	MA0505.2	Nr5A2	MA0505.2	NTGACCTTGAMCT	Nr5A2	0.00724	5.56e-06	3360	26.7	4990	24.5	1.09
451	54	MA0807.1	TBX5	MA0807.1	AGGTGTKA	TBX5	0.00799	6.12e-06	1160	9.22	1600	7.86	1.17
452	3	MA1944.1	ETV5::DRGX	MA1944.1	RSMGGAAGYAATTA	ETV5::DRGX	0.00818	6.25e-06	7660	60.9	11900	58.5	1.04
453	38	MA0062.3	GABPA	MA0062.3	NNCACTTCCTGTNN	GABPA	0.00877	6.68e-06	10900	86.9	17300	85.2	1.02
454	38	MA0761.2	ETV1	MA0761.2	NNACAGGAAGTGNN	ETV1	0.0104	7.92e-06	10400	82.5	16400	80.7	1.02
14	90	MA1599.1 (ZNF682)	STREME-10	10-CCAAGCCCAGGC	10-CCAAGCCCAGGC	ZNF682	0.011	0.000783	153	1.22	172	0.85	1.44
455	38	MA0136.3	Elf5	MA0136.3	RVAAGGAAGTNN	Elf5	0.0111	8.45e-06	11900	94.3	19000	93.1	1.01
456	63	MA1620.1	Ptf1A	MA1620.1	NVACACCTGTNN	Ptf1A	0.0112	8.51e-06	10300	81.8	16300	79.9	1.02
457	76	MA0783.1	PKNOX2	MA0783.1	TGACAGGTGTCA	PKNOX2	0.0123	9.33e-06	455	3.62	566	2.78	1.3
458	49	MA0517.1	STAT1::STAT2	MA0517.1	THAGTTTCRKTTTCY	STAT1::STAT2	0.0141	1.07e-05	5670	45	8690	42.7	1.05
459	87	MA0838.1	CEBPG	MA0838.1	ATTRCGCAAY	CEBPG	0.0231	1.73e-05	986	7.84	1350	6.65	1.18
460	88	MA0101.1	REL	MA0101.1	BGGRNWTTCC	REL	0.0276	2.07e-05	8770	69.7	13800	67.6	1.03
461	63	MA0006.1	Ahr::Arnt	MA0006.1	YGCGTG	Ahr::Arnt	0.0318	2.38e-05	10700	85.2	17000	83.5	1.02
462	89	MA1594.1	ZNF382	MA1594.1	AGGRGAYATCACYACMGAYCCCAC	ZNF382	0.0331	2.47e-05	1020	8.09	1410	6.91	1.17
463	54	MA1566.2	TBX3	MA1566.2	RAGGTGTGAAV	TBX3	0.0354	2.64e-05	3060	24.3	4560	22.4	1.08
464	38	MA0473.3	ELF1	MA0473.3	RDVCAGGAAGTGVN	ELF1	0.0357	2.65e-05	10300	81.9	16300	80.1	1.02
465	3	MA0703.2	LMX1B	MA0703.2	AWTTTAATTAA	LMX1B	0.0395	2.93e-05	524	4.16	676	3.32	1.25
466	38	MA1956.1	FOXO1::FLI1	MA1956.1	GTAAACAGGAAGTK	FOXO1::FLI1	0.0431	3.19e-05	1100	8.77	1540	7.56	1.16
15	91	MA1107.2 (KLF9)	MEME-3	CACACACACACACAC	CACACACACACACAC	KLF9	10.6	0.707	17	0.14	29	0.14	0.971
16	92	MA1961.1 (PATZ1)	MEME-2	GGSRGGGGGCGGGGC	GGSRGGGGGCGGGGC	PATZ1	12.1	0.759	9	0.07	17	0.08	0.899
17	92	MA1965.1 (SP5)	MEME-7	GRGRRGGAGGRRGDG	GRGRRGGAGGRRGDG	SP5	17	1	5830	46.4	9850	48.4	0.958

ER_rat <- 1.25

EPI_242kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("EPI_242kb_combo response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

EPI_242kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y, TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*4), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( "EPI_24 2kb response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

EPI_DAR 24 20kb data

EPI_24_20kb_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_24_20kb_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
EPI_24_20kb_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_24_20kb_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
EPI_24_20kb_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_24_20kb_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
EPI_24_20kb_sea_all <- rbind(EPI_24_20kb_sea_disc, EPI_24_20kb_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

EPI_24_20kb_combo <- EPI_24_20kb_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., EPI_24_20kb_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

EPI_24_20kb_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EPI_24h 20kb") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in EPI_24h 20kb
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA1134.1 (FOS::JUNB)	STREME-1	1-RATGASTCATY	RATGASTCATY	FOS::JUNB	0	0	5480	15	3320	6.6	2.28
2	1	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	0	0	6050	16.6	4020	7.98	2.08
3	1	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	0	0	5460	15	3450	6.85	2.19
4	1	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	1.24998608397835e-320	1.06224113855868e-321	4810	13.2	2850	5.66	2.34
5	1	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	2.38001302914645e-319	2.20007432093107e-320	5540	15.2	3560	7.08	2.15
6	1	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	9.10000244514804e-318	7.1199800222182e-319	4910	13.5	2950	5.87	2.3
7	1	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	5.82000000000717e-313	3.90000000000735e-314	5580	15.3	3640	7.23	2.12
8	1	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	4.80000000000004e-311	2.8200000000019e-312	4400	12.1	2510	4.98	2.43
9	1	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	1.03e-309	5.36000000000007e-311	4430	12.2	2540	5.05	2.41
10	1	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	2.61e-309	1.22000000000001e-310	4500	12.4	2610	5.18	2.38
11	1	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	1.05e-304	4.35e-306	4940	13.6	3040	6.05	2.24
12	1	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	1.11e-304	4.35e-306	5450	15	3550	7.05	2.12
13	1	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	4.73e-304	1.71e-305	4350	12	2490	4.95	2.41
14	1	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	3.87e-303	1.3e-304	4780	13.1	2910	5.77	2.28
15	1	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	1.34e-301	4.18e-303	5420	14.9	3540	7.02	2.12
16	1	MA0476.1 (FOS)	MEME-2	ATGASTCASH	ATGASTCASH	FOS	2.27e-295	6.66e-297	4640	12.8	2810	5.59	2.28
17	1	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	1.68e-293	4.62e-295	5150	14.1	3310	6.57	2.15
18	1	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	1.48e-290	3.85e-292	5220	14.3	3400	6.75	2.12
19	1	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	4.54e-289	1.12e-290	4890	13.4	3080	6.13	2.19
20	1	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	8.72999999999999e-288	2.05e-289	4530	12.4	2740	5.45	2.28
21	1	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	2.06e-284	4.6e-286	6460	17.8	4710	9.35	1.9
22	1	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	6.12e-280	1.31e-281	5160	14.2	3400	6.75	2.1
23	1	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	2.84e-273	5.79e-275	5480	15.1	3760	7.46	2.02
24	1	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	6.07e-270	1.19e-271	6050	16.6	4370	8.67	1.92
25	1	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	2.35e-264	4.41e-266	4060	11.2	2420	4.8	2.33
26	1	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	5.41e-262	9.76e-264	4870	13.4	3210	6.37	2.1
27	1	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	1.61e-260	2.8e-262	6040	16.6	4420	8.77	1.89
28	1	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	1.87e-245	3.13e-247	5130	14.1	3560	7.08	1.99
29	1	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	5.17e-154	8.36e-156	6800	18.7	6090	12.1	1.54
30	1	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	1.57e-137	2.45e-139	5360	14.7	4610	9.15	1.61
31	1	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	1.43e-126	2.17e-128	8160	22.4	8000	15.9	1.41
32	1	MA0150.2	Nfe2l2	MA0150.2	CASNATGACTCAGCA	Nfe2l2	9.41e-90	1.38e-91	8360	23	8740	17.4	1.32
33	2	MA1991.1 (Hnf1A)	STREME-8	8-TCAAAG	TCAAAG	Hnf1A	7.75e-78	1.1e-79	32700	89.7	43000	85.4	1.05
34	1	MA1137.1 (FOSL1::JUNB)	STREME-2	2-ABTCAKM	ABTCAKM	FOSL1::JUNB	7.34e-76	1.01e-77	24600	67.5	30900	61.4	1.1
35	1	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	7.98e-76	1.07e-77	4670	12.8	4450	8.84	1.45
36	3	MA0720.1	Shox2	MA0720.1	YYAATTAR	Shox2	2.16e-74	2.82e-76	31100	85.5	40600	80.7	1.06
37	3	MA0723.2	VAX2	MA0723.2	BYAATTAV	VAX2	3.3e-73	4.18e-75	30900	85	40400	80.2	1.06
38	4	MA0084.1	SRY	MA0084.1	NWWAACAAT	SRY	2.58e-71	3.18e-73	32800	90	43200	85.9	1.05
39	3	MA0027.2	EN1	MA0027.2	SYAATTAV	EN1	4.92e-71	5.92e-73	31100	85.5	40700	80.8	1.06
40	5	9-ATNAGG	STREME-9	9-ATNAGG	ATNAGG	ATNAGG	6.67e-71	7.82e-73	32100	88.1	42100	83.7	1.05
41	3	MA0718.1	RAX	MA0718.1	RYYAATTARH	RAX	2.42e-70	2.77e-72	29300	80.4	37900	75.3	1.07
42	3	MA0725.1	VSX1	MA0725.1	YTAATTAN	VSX1	2.84e-68	3.18e-70	32700	89.9	43200	85.9	1.05
43	1	MA1639.1	MEIS1	MA1639.1	NHCATMAATCAHN	MEIS1	3.66e-68	3.99e-70	25200	69.1	31900	63.3	1.09
44	6	MA0676.1	Nr2e1	MA0676.1	AAAAGTCAA	Nr2e1	4.08e-67	4.35e-69	24300	66.7	30700	60.9	1.1
45	7	MA1963.1	SATB1	MA1963.1	WWDCTAATAAHWW	SATB1	4.74e-67	4.94e-69	24300	66.7	30700	60.9	1.1
46	3	MA0886.1	EMX2	MA0886.1	VBTAATTARB	EMX2	8.66e-67	8.83e-69	23100	63.5	29000	57.5	1.1
47	3	MA0902.2	HOXB2	MA0902.2	SYAATTAS	HOXB2	2.65e-66	2.64e-68	22300	61.4	27900	55.4	1.11
48	3	MA0726.1	VSX2	MA0726.1	CTAATTAN	VSX2	2.13e-64	2.08e-66	32600	89.4	43000	85.5	1.05
49	3	MA0704.1	Lhx4	MA0704.1	YTAATTAR	Lhx4	4.31e-64	4.12e-66	31500	86.6	41400	82.3	1.05
50	1	MA1113.2	PBX2	MA1113.2	NHCATAAATCAHN	PBX2	6.29e-63	5.91e-65	28300	77.8	36600	72.8	1.07
51	3	MA0710.1	NOTO	MA0710.1	NYTAATTAVN	NOTO	4.18e-62	3.85e-64	25700	70.5	32700	65	1.08
52	3	MA0644.2	ESX1	MA0644.2	YYAATTAN	ESX1	1.11e-61	1e-63	24900	68.3	31600	62.8	1.09
53	8	MA0142.1	Pou5f1::Sox2	MA0142.1	CWTTGTYATGCAAAT	Pou5f1::Sox2	2.24e-61	1.98e-63	27700	76.1	35700	70.9	1.07
54	3	MA0674.1	NKX6-1	MA0674.1	NTMATTAA	NKX6-1	1.04e-60	8.99e-63	33000	90.5	43700	86.9	1.04
55	1	MA1640.1	MEIS2	MA1640.1	NNATGATTTATGDNH	MEIS2	2.65e-59	2.26e-61	29600	81.3	38600	76.6	1.06
56	3	MA0634.1	ALX3	MA0634.1	YYYAATTANV	ALX3	4.88e-59	4.09e-61	31600	86.9	41700	82.8	1.05
57	8	MA0786.1	POU3F1	MA0786.1	WTATGCWAATKW	POU3F1	5.71e-59	4.7e-61	28900	79.5	37600	74.7	1.06
58	3	MA0680.2	Pax7	MA0680.2	DWTAATCAATTAWNH	Pax7	1.68e-58	1.36e-60	24300	66.7	30800	61.3	1.09
59	9	MA0650.3	Hoxa13	MA0650.3	NNCCAATAAAAN	Hoxa13	1.82e-58	1.45e-60	29900	82.1	39000	77.5	1.06
60	10	MA1104.2	GATA6	MA1104.2	HWWTCTTATCTNH	GATA6	1.96e-58	1.53e-60	27800	76.4	36000	71.4	1.07
61	8	MA0788.1	POU3F3	MA0788.1	WWTATGCWAATTW	POU3F3	2.74e-58	2.11e-60	26600	73	34200	67.9	1.08
62	10	MA0035.4	GATA1	MA0035.4	NHCTAATCTDH	GATA1	4.3e-58	3.25e-60	28600	78.5	37100	73.7	1.07
63	8	MA0785.1	POU2F1	MA0785.1	AWTATGCWAATK	POU2F1	5.47e-58	4.08e-60	28600	78.7	37200	73.9	1.07
64	3	MA0713.1	PHOX2A	MA0713.1	TAATYYAATTA	PHOX2A	1.96e-57	1.43e-59	25400	69.7	32400	64.4	1.08
65	3	MA0628.1	POU6F1	MA0628.1	AYTAATTART	POU6F1	2.21e-57	1.59e-59	28900	79.3	37500	74.5	1.06
66	3	MA0879.2	DLX1	MA0879.2	VYAATTAN	DLX1	4.58e-57	3.25e-59	33600	92.4	44900	89.2	1.04
67	3	MA0890.1	GBX2	MA0890.1	RSYAATTARN	GBX2	4.65e-57	3.25e-59	27500	75.6	35600	70.6	1.07
68	3	MA1476.2	Dlx5	MA1476.2	NDGCAATTAGNN	Dlx5	7.13e-57	4.92e-59	31500	86.4	41500	82.4	1.05
69	3	MA0904.2	HOXB5	MA0904.2	STAATTAS	HOXB5	9.09e-57	6.18e-59	20800	57.1	26000	51.6	1.11
70	11	MA0041.2	FOXD3	MA0041.2	WAWGHAAATAAACARY	FOXD3	1.58e-56	1.06e-58	29200	80.1	38000	75.4	1.06
71	11	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	2.47e-56	1.63e-58	28000	76.8	36200	71.9	1.07
72	3	MA0654.1	ISX	MA0654.1	YYAATTAR	ISX	4.62e-56	3.01e-58	21500	59	26900	53.5	1.1
73	3	MA0889.1	GBX1	MA0889.1	VCYAATTASY	GBX1	1.19e-55	7.64e-58	26200	71.8	33600	66.7	1.08
74	3	MA1481.1	DRGX	MA1481.1	YYAATTAN	DRGX	1.44e-55	9.12e-58	29100	80	37900	75.3	1.06
75	3	MA0675.1	NKX6-2	MA0675.1	NYMATTAA	NKX6-2	2.2e-55	1.37e-57	33200	91.1	44100	87.7	1.04
76	3	MA0882.1	DLX6	MA0882.1	VYAATTAN	DLX6	2.21e-55	1.37e-57	33900	93	45300	89.9	1.03
77	3	MA1502.1	HOXB8	MA1502.1	GYMATTAM	HOXB8	8.27e-55	5.04e-57	19400	53.2	24000	47.7	1.12
78	12	MA0052.4	MEF2A	MA0052.4	DDCTAAAAATAGMHH	MEF2A	1.19e-54	7.17e-57	26100	71.6	33500	66.5	1.08
79	8	MA0789.1	POU3F4	MA0789.1	TATGCWAAT	POU3F4	2.47e-54	1.47e-56	24700	68	31600	62.8	1.08
80	3	MA0125.1	Nobox	MA0125.1	TAATTRSY	Nobox	3.65e-54	2.14e-56	30300	83.1	39700	78.8	1.05
81	13	MA1480.1	DPRX	MA1480.1	AGATAATCCN	DPRX	4.12e-54	2.39e-56	29300	80.4	38200	75.9	1.06
82	9	MA0465.2	CDX2	MA0465.2	NDGCAATAAAWN	CDX2	4.97e-54	2.85e-56	29300	80.4	38200	75.9	1.06
83	3	MA0722.1	VAX1	MA0722.1	YTAATTAH	VAX1	6.26e-54	3.54e-56	33100	91	44100	87.6	1.04
84	14	MA0635.1	BARHL2	MA0635.1	VHTAAAYGRT	BARHL2	8.09e-54	4.52e-56	31300	86	41300	82	1.05
85	9	MA0901.2	HOXB13	MA0901.2	WDCCAATAAAAWWW	HOXB13	8.43e-54	4.66e-56	25400	69.8	32500	64.6	1.08
86	9	MA0899.1	HOXA10	MA0899.1	DGYMATAAAAH	HOXA10	1.71e-53	9.32e-56	25300	69.4	32400	64.3	1.08
87	3	MA0793.1	POU6F2	MA0793.1	ASCTMATTAW	POU6F2	2.02e-53	1.08e-55	28000	76.8	36300	72.1	1.07
88	3	MA0158.2	HOXA5	MA0158.2	GYMATTAS	HOXA5	2.03e-53	1.08e-55	17200	47.1	21000	41.7	1.13
89	8	MA0787.1	POU3F2	MA0787.1	WTATGCWAATKA	POU3F2	2.61e-53	1.38e-55	25100	69	32200	63.9	1.08
90	3	MA0721.1	UNCX	MA0721.1	YYAATTAV	UNCX	5.57e-53	2.9e-55	32500	89.4	43200	85.8	1.04
91	3	MA0876.1	BSX	MA0876.1	SYVATTAV	BSX	1.57e-52	8.1e-55	30000	82.4	39300	78.2	1.05
92	3	MA1495.1	HOXA1	MA1495.1	STAATTAS	HOXA1	2.96e-52	1.51e-54	16400	45.2	20100	39.9	1.13
93	3	MA1505.1	HOXC8	MA1505.1	KTAATTAM	HOXC8	3.44e-52	1.74e-54	32300	88.8	42900	85.1	1.04
94	3	MA0707.2	MNX1	MA0707.2	VYRATTAK	MNX1	5.13e-52	2.56e-54	19100	52.5	23800	47.2	1.11
95	3	MA0709.1	Msx3	MA0709.1	SCAATTAN	Msx3	6.43e-52	3.18e-54	28800	79.1	37600	74.6	1.06
96	3	MA0885.2	Dlx2	MA0885.2	NDGCAATTAGNN	Dlx2	1.54e-51	7.53e-54	32400	89.1	43100	85.6	1.04
97	3	MA0708.2	MSX2	MA0708.2	SCAATTAV	MSX2	1.91e-51	9.23e-54	27900	76.6	36200	71.9	1.06
98	3	MA0601.1	Arid3b	MA0601.1	ATATTAATWAN	Arid3b	4.98e-51	2.38e-53	21600	59.2	27200	54	1.1
99	3	MA0658.1	LHX6	MA0658.1	RCTAATTARY	LHX6	7.17e-51	3.4e-53	22500	61.8	28500	56.6	1.09
100	10	MA0036.3	GATA2	MA0036.3	NBCTTATCTNH	GATA2	1.37e-50	6.42e-53	30400	83.6	40000	79.5	1.05
101	15	MA0791.1	POU4F3	MA0791.1	RTGMATWATTAATGAR	POU4F3	1.76e-50	8.16e-53	21800	60	27600	54.8	1.1
102	3	MA0716.1	PRRX1	MA0716.1	YYAATTAR	PRRX1	2.63e-50	1.21e-52	33900	93.2	45500	90.3	1.03
103	3	MA0701.2	LHX9	MA0701.2	CYAATTAR	LHX9	3.9e-50	1.78e-52	15200	41.7	18400	36.6	1.14
104	3	MA0700.2	LHX2	MA0700.2	DDCCAATTADN	LHX2	5.47e-50	2.47e-52	28400	78	37000	73.5	1.06
105	8	MA0792.1	POU5F1B	MA0792.1	TATGCWAAT	POU5F1B	5.64e-50	2.52e-52	31900	87.8	42300	84.1	1.04
106	16	MA0018.4 (CREB1)	STREME-3	3-ATGWCAT	ATGWCAT	CREB1	8.62e-50	3.82e-52	34600	94.9	46500	92.4	1.03
107	11	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	8.8e-50	3.86e-52	32600	89.6	43400	86.2	1.04
108	3	MA0648.1	GSC	MA0648.1	VYTAATCCSY	GSC	1.33e-49	5.77e-52	28900	79.3	37700	74.9	1.06
109	3	MA0666.2	MSX1	MA0666.2	SCAATTAR	MSX1	2.24e-49	9.64e-52	24100	66.3	30800	61.2	1.08
110	17	MA0495.3	MAFF	MA0495.3	DWGTCAGCATTTTWHN	MAFF	2.78e-49	1.18e-51	31100	85.5	41100	81.6	1.05
111	3	MA0910.2	HOXD8	MA0910.2	GYMATTAM	HOXD8	6.8e-49	2.87e-51	17200	47.4	21300	42.2	1.12
112	15	MA0790.1	POU4F1	MA0790.1	ATGMATAATTAATG	POU4F1	1.33e-48	5.57e-51	22100	60.7	28000	55.6	1.09
113	11	MA0032.2	FOXC1	MA0032.2	WAWGTAAAYAW	FOXC1	1.68e-47	6.96e-50	29200	80.3	38300	76.1	1.06
114	3	MA1497.1	HOXA6	MA1497.1	BGYMATTANN	HOXA6	1.7e-47	6.98e-50	31100	85.4	41100	81.6	1.05
115	8	MA0627.2	POU2F3	MA0627.2	NWTATGCAAATNH	POU2F3	1.92e-47	7.85e-50	26700	73.2	34500	68.6	1.07
116	3	MA0681.2	PHOX2B	MA0681.2	WWTAATCAAATTAWWW	PHOX2B	2.46e-47	9.95e-50	21000	57.6	26400	52.5	1.1
117	3	MA0630.1	SHOX	MA0630.1	HTAATTRR	SHOX	3.63e-47	1.45e-49	34300	94.3	46100	91.6	1.03
118	18	MA0769.2	TCF7	MA0769.2	NNCTTTGAWVT	TCF7	3.64e-47	1.45e-49	34000	93.5	45700	90.8	1.03
119	3	MA1549.1	POU6F1	MA1549.1	RTAATGAGVN	POU6F1	4.91e-47	1.93e-49	30100	82.6	39600	78.6	1.05
120	3	MA0661.1	MEOX1	MA0661.1	VSTAATTAHC	MEOX1	5.54e-47	2.17e-49	31100	85.4	41100	81.6	1.05
121	10	MA1970.1	TRPS1	MA1970.1	NHTCTTATCTNH	TRPS1	5.83e-47	2.26e-49	30000	82.4	39500	78.4	1.05
122	3	MA1518.2	Lhx1	MA1518.2	NNNTGCTAATTAGCANNN	Lhx1	5.87e-47	2.26e-49	27300	74.9	35400	70.3	1.06
123	3	MA0068.2	PAX4	MA0068.2	CTAATTAG	PAX4	7.26e-47	2.77e-49	30900	84.9	40800	81.1	1.05
124	3	MA1471.1	BARX2	MA1471.1	NWWAAYMATTAN	BARX2	8.49e-47	3.21e-49	28000	77	36500	72.5	1.06
125	3	MA0912.2	HOXD3	MA0912.2	CTAATTAC	HOXD3	3.33e-46	1.25e-48	13700	37.5	16500	32.7	1.15
126	19	MA0905.1	HOXC10	MA0905.1	GTCRTAAAAH	HOXC10	4.32e-46	1.61e-48	24500	67.3	31400	62.5	1.08
127	3	MA0894.1	HESX1	MA0894.1	GHTAATTRRH	HESX1	1.53e-45	5.65e-48	22600	62.2	28800	57.3	1.09
128	3	MA0706.1	MEOX2	MA0706.1	DSTAATTAWN	MEOX2	6.1e-45	2.24e-47	31800	87.4	42200	83.9	1.04
129	4	MA0143.4	SOX2	MA0143.4	DNACAATGGNN	SOX2	1.26e-44	4.59e-47	30600	84	40400	80.2	1.05
130	3	MA0642.2	EN2	MA0642.2	VSYAATTA	EN2	3.87e-44	1.4e-46	28800	79.1	37700	74.9	1.06
131	3	MA1519.1	LHX5	MA1519.1	STAATTAV	LHX5	7.61e-44	2.73e-46	14500	39.8	17600	35	1.14
132	20	MA1657.1	ZNF652	MA1657.1	BAAAGRGTTAAN	ZNF652	8.5e-44	3.02e-46	30300	83.3	40000	79.4	1.05
133	21	MA0122.3	Nkx3-2	MA0122.3	WWAAMCACTTAAN	Nkx3-2	9.85e-44	3.47e-46	27400	75.2	35600	70.8	1.06
134	11	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	1.12e-43	3.93e-46	30200	82.8	39700	79	1.05
135	11	MA1978.1	ZNF354A	MA1978.1	HWAADWATAAATGRAYWAWTT	ZNF354A	1.51e-43	5.25e-46	25100	69	32400	64.3	1.07
136	3	MA0711.1	OTX1	MA0711.1	HTAATCCS	OTX1	2.14e-43	7.38e-46	31400	86.3	41600	82.7	1.04
137	8	MA1115.1	POU5F1	MA1115.1	WHATGCAAATN	POU5F1	7.01e-43	2.4e-45	31400	86.2	41600	82.6	1.04
138	3	MA0903.1	HOXB3	MA0903.1	NNYMATTARN	HOXB3	7.34e-43	2.5e-45	31900	87.6	42400	84.2	1.04
139	22	MA0047.3	FOXA2	MA0047.3	RWGTAAACANN	FOXA2	3e-42	1.01e-44	32000	87.8	42500	84.4	1.04
140	23	MA0499.2 (MYOD1)	STREME-5	5-AGACAGG	AGACAGG	MYOD1	6.66e-42	2.23e-44	27900	76.6	36500	72.4	1.06
141	3	MA0892.1	GSX1	MA0892.1	NCYMATTAVN	GSX1	8.32e-42	2.77e-44	30600	84	40400	80.3	1.05
142	3	MA0705.1	Lhx8	MA0705.1	CTAATTAV	Lhx8	1.06e-41	3.52e-44	19700	54.2	24900	49.4	1.1
143	22	MA0148.4	FOXA1	MA0148.4	WWGTAAACATNN	FOXA1	1.32e-41	4.33e-44	31500	86.5	41800	83.1	1.04
144	4	MA1152.1	SOX15	MA1152.1	CYWTTGTTHW	SOX15	5e-41	1.63e-43	33500	91.9	44900	89.1	1.03
145	22	MA0031.1	FOXD1	MA0031.1	GTAAACAW	FOXD1	6.59e-41	2.13e-43	21900	60	27900	55.4	1.09
146	11	MA1607.1	Foxl2	MA1607.1	DDWATGTAAACANN	Foxl2	7.51e-41	2.41e-43	31500	86.5	41800	83.1	1.04
147	22	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	2.5e-40	7.99e-43	30300	83.2	40000	79.4	1.05
148	3	MA1530.1	NKX6-3	MA1530.1	VYCATTAWW	NKX6-3	4.47e-40	1.42e-42	19800	54.5	25100	49.8	1.09
149	10	MA0037.4	Gata3	MA0037.4	NHTCTTATCTNH	Gata3	7.08e-40	2.23e-42	31700	87.2	42200	83.8	1.04
150	4	MA0077.1	SOX9	MA0077.1	CYATTGTTY	SOX9	3.74e-39	1.17e-41	34900	95.8	47200	93.8	1.02
151	3	MA0875.1	BARX1	MA0875.1	VCMATTAV	BARX1	8.22e-39	2.55e-41	27900	76.7	36600	72.6	1.06
152	3	MA0075.3	PRRX2	MA0075.3	CTAATTAN	PRRX2	3.82e-38	1.18e-40	14900	40.9	18300	36.4	1.12
153	24	MA0108.2	TBP	MA0108.2	STATAAAWRSVVVBN	TBP	6.16e-38	1.89e-40	29100	79.9	38300	76.1	1.05
154	15	MA0153.2	HNF1B	MA0153.2	GTTAATNATTAAY	HNF1B	9.18e-38	2.8e-40	15200	41.7	18700	37.2	1.12
155	3	MA0612.2	EMX1	MA0612.2	BTAATTAS	EMX1	1.17e-37	3.55e-40	11600	31.9	14000	27.7	1.15
156	25	MA0895.1	HMBOX1	MA0895.1	MYTAGTTAMS	HMBOX1	1.76e-37	5.31e-40	32400	88.9	43200	85.8	1.04
157	3	MA0900.2	HOXA2	MA0900.2	STAATTAS	HOXA2	2.58e-37	7.71e-40	14000	38.6	17200	34.2	1.13
158	26	MA0025.2	NFIL3	MA0025.2	NRTTATGYAATNN	NFIL3	3.07e-37	9.11e-40	28900	79.2	38000	75.4	1.05
159	10	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	4.31e-37	1.27e-39	17200	47.3	21500	42.8	1.11
160	3	MA0717.1	RAX2	MA0717.1	YYAATTAV	RAX2	6.66e-37	1.95e-39	34800	95.5	47000	93.4	1.02
161	3	MA0891.1	GSC2	MA0891.1	NYTAATCCBH	GSC2	9.95e-37	2.9e-39	33200	91.2	44500	88.5	1.03
162	22	MA0481.3	FOXP1	MA0481.3	NDGTAAACANH	FOXP1	1.22e-36	3.52e-39	28600	78.5	37600	74.7	1.05
163	3	MA1463.1	ARGFX	MA1463.1	DCTAATTARM	ARGFX	1.29e-36	3.71e-39	15900	43.6	19700	39.2	1.11
164	11	MA0157.3	Foxo3	MA0157.3	NDGTAAACARNN	Foxo3	1.68e-36	4.81e-39	31800	87.3	42400	84.2	1.04
165	13	MA0682.2	PITX1	MA0682.2	YTAATCCH	PITX1	2.44e-36	6.93e-39	19000	52	23900	47.6	1.09
166	15	MA0046.2	HNF1A	MA0046.2	DRTTAATNATTAACN	HNF1A	2.45e-36	6.93e-39	15500	42.5	19200	38.1	1.12
167	4	MA1563.2	SOX18	MA1563.2	AACAATDV	SOX18	3.7e-36	1.04e-38	27600	75.9	36200	72	1.05
168	27	MA0602.1	Arid5a	MA0602.1	SYAATATTGVDANH	Arid5a	4.41e-36	1.23e-38	22800	62.6	29300	58.2	1.08
169	3	MA1608.1	Isl1	MA1608.1	NNCCATTAGNN	Isl1	5.1e-36	1.42e-38	33700	92.7	45400	90.2	1.03
170	3	MA0898.1	Hmx3	MA0898.1	ASAAGCAATTAAWRRAT	Hmx3	6.69e-36	1.85e-38	21600	59.4	27700	55	1.08
171	12	MA0497.1	MEF2C	MA0497.1	DDDCYAAAAATAGMW	MEF2C	7.79e-36	2.14e-38	22900	62.9	29400	58.5	1.07
172	28	MA0809.2	TEAD4	MA0809.2	NNACATTCCARN	TEAD4	9.33e-36	2.55e-38	27600	75.9	36200	72	1.05
173	22	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	1.15e-35	3.12e-38	29600	81.4	39200	77.8	1.05
174	4	MA0868.2	SOX8	MA0868.2	MGAACAATRG	SOX8	1.22e-35	3.3e-38	33200	91.2	44500	88.4	1.03
175	13	MA0712.2	OTX2	MA0712.2	NDRGGATTARNN	OTX2	1.48e-35	3.97e-38	26500	72.8	34600	68.7	1.06
176	3	MA0662.1	MIXL1	MA0662.1	NBYAATTAVN	MIXL1	3.59e-35	9.58e-38	34600	95.1	46800	93	1.02
177	4	MA1120.1	SOX13	MA1120.1	DVACAATGGNN	SOX13	1.29e-34	3.43e-37	30600	84.1	40700	80.8	1.04
178	9	MA0909.3	Hoxd13	MA0909.3	NNCAATAAAW	Hoxd13	2.39e-34	6.31e-37	22100	60.7	28400	56.4	1.08
179	29	7-AGAATA	STREME-7	7-AGAATA	AGAATA	AGAATA	5e-34	1.31e-36	32800	90.1	44000	87.4	1.03
180	22	MA0042.2	FOXI1	MA0042.2	GTAAACA	FOXI1	5.6e-34	1.46e-36	26200	72	34300	68	1.06
181	30	MA0018.4	CREB1	MA0018.4	NNRTGATGTCAYN	CREB1	1.09e-33	2.83e-36	28100	77.1	36900	73.3	1.05
182	22	MA1103.2	FOXK2	MA1103.2	DDGTAAACANN	FOXK2	1.84e-33	4.75e-36	34000	93.4	45900	91.1	1.03
183	3	MA0888.1	EVX2	MA0888.1	VVTAATTAVB	EVX2	2.16e-33	5.53e-36	33000	90.5	44200	87.8	1.03
184	31	MA1125.1 (ZNF384)	MEME-1	THTTTTTKTWTTTTT	THTTTTTKTWTTTTT	ZNF384	3.33e-33	8.48e-36	22600	62	29100	57.8	1.07
185	4	MA0514.2	Sox3	MA0514.2	DNACAATGGNN	Sox3	4.04e-33	1.02e-35	32100	88.2	43000	85.3	1.03
186	22	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	4.17e-33	1.05e-35	31300	86	41700	82.8	1.04
187	4	MA0078.2	Sox17	MA0078.2	NNAGAACAATGGNN	Sox17	8.89e-33	2.23e-35	30900	84.9	41100	81.7	1.04
188	26	MA0102.4	CEBPA	MA0102.4	NDATTGCACAATHN	CEBPA	1.04e-32	2.59e-35	30000	82.3	39700	79	1.04
189	3	MA0881.1	Dlx4	MA0881.1	VYAATTAN	Dlx4	1.06e-32	2.64e-35	35200	96.6	47800	94.9	1.02
190	3	MA0914.1	ISL2	MA0914.1	GCAMTTAR	ISL2	1.28e-32	3.15e-35	30500	83.7	40500	80.4	1.04
191	4	MA1562.1	SOX14	MA1562.1	CCGAACAATG	SOX14	1.66e-32	4.09e-35	27200	74.7	35700	70.9	1.05
192	3	MA1498.2	HOXA7	MA1498.2	SYMATTAV	HOXA7	1.84e-32	4.48e-35	34300	94.3	46400	92.1	1.02
193	18	MA0523.1	TCF7L2	MA0523.1	DRASATCAAAGRVA	TCF7L2	2.31e-32	5.62e-35	22800	62.6	29400	58.5	1.07
194	3	MA0893.2	GSX2	MA0893.2	SYMATTAR	GSX2	3.24e-32	7.83e-35	30700	84.4	40800	81.1	1.04
195	3	MA0132.2	PDX1	MA0132.2	VYAATTAR	PDX1	1.26e-31	3.03e-34	20100	55.2	25700	51.1	1.08
196	17	MA0842.2	NRL	MA0842.2	AAWWNTGCTGACG	NRL	3.06e-31	7.32e-34	14900	41	18600	36.9	1.11
197	13	MA0467.2	Crx	MA0467.2	NDGGATTANN	Crx	1.31e-30	3.12e-33	26500	72.7	34700	68.9	1.05
198	3	MA0854.1	Alx1	MA0854.1	CGMRYTAATTARTNMNY	Alx1	1.33e-30	3.15e-33	15000	41.3	18800	37.3	1.11
199	32	MA0755.1	CUX2	MA0755.1	TRATCGATAW	CUX2	1.55e-30	3.65e-33	17100	46.9	21500	42.8	1.1
200	32	MA0679.2	ONECUT1	MA0679.2	WAAAAATCAATAAWWN	ONECUT1	1.64e-30	3.84e-33	14800	40.6	18400	36.6	1.11
201	33	MA0070.1	PBX1	MA0070.1	HCATCAATCAAW	PBX1	5.35e-30	1.25e-32	15500	42.6	19400	38.6	1.1
202	3	MA0618.1	LBX1	MA0618.1	TTAATTAG	LBX1	5.94e-30	1.38e-32	19800	54.3	25300	50.2	1.08
203	28	MA0090.3	TEAD1	MA0090.3	NNACATTCCAGSN	TEAD1	1.36e-29	3.15e-32	29300	80.6	38900	77.2	1.04
204	26	MA1636.1	CEBPG	MA1636.1	NDATGATGCAATMHH	CEBPG	4.52e-28	1.04e-30	23100	63.6	30100	59.7	1.06
205	34	MA0151.1	Arid3a	MA0151.1	ATYAAA	Arid3a	4.71e-28	1.08e-30	15000	41.1	18700	37.2	1.1
206	1	MA0591.1	Bach1::Mafk	MA0591.1	RSSATGACTCAGCAB	Bach1::Mafk	6.68e-28	1.52e-30	2740	7.54	2820	5.59	1.35
207	35	MA0483.1	Gfi1B	MA0483.1	AAATCWCWGCH	Gfi1B	1.56e-27	3.54e-30	20100	55.3	25900	51.4	1.08
208	11	MA0852.2	FOXK1	MA0852.2	NRDGTAAACAAGNN	FOXK1	2.71e-27	6.11e-30	32300	88.8	43400	86.2	1.03
209	9	MA0878.3	CDX1	MA0878.3	GGYMATAAAA	CDX1	3.01e-27	6.77e-30	14300	39.4	17900	35.6	1.11
210	3	MA1499.1	HOXB4	MA1499.1	RTMATTAR	HOXB4	4.48e-27	1e-29	15800	43.4	19900	39.6	1.1
211	21	MA0124.2	Nkx3-1	MA0124.2	RCCACTTAA	Nkx3-1	5.92e-27	1.32e-29	27700	76.2	36600	72.8	1.05
212	26	MA0836.2	CEBPD	MA0836.2	NRTTGCACAAYHN	CEBPD	9.6e-27	2.13e-29	28300	77.6	37400	74.3	1.04
213	3	MA0880.1	Dlx3	MA0880.1	NYAATTAN	Dlx3	1.61e-26	3.55e-29	35200	96.8	48000	95.3	1.02
214	3	MA0724.1	VENTX	MA0724.1	AMCGATTAR	VENTX	3.14e-26	6.89e-29	12500	34.3	15400	30.7	1.12
215	17	MA0117.2	Mafb	MA0117.2	AWWNTGCTGACD	Mafb	4.65e-26	1.01e-28	32300	88.8	43400	86.2	1.03
216	3	MA1500.1	HOXB6	MA1500.1	BTAATKRC	HOXB6	5.6e-26	1.22e-28	35300	97	48100	95.5	1.02
217	13	MA0714.1	PITX3	MA0714.1	NYTAATCCC	PITX3	5.89e-26	1.27e-28	35300	96.9	48100	95.5	1.02
218	3	MA0853.1	Alx4	MA0853.1	CGCRYTAATTARYHNNY	Alx4	1.18e-24	2.54e-27	13900	38.1	17400	34.5	1.1
219	22	MA1489.1	FOXN3	MA1489.1	GTAAACAA	FOXN3	1.57e-24	3.36e-27	23100	63.4	30100	59.8	1.06
220	36	MA1623.1	Stat2	MA1623.1	RGAAACAGAAASH	Stat2	2.28e-24	4.86e-27	32000	88	43000	85.5	1.03
221	3	MA1577.1	TLX2	MA1577.1	BYAATTAR	TLX2	2.41e-24	5.11e-27	12100	33.2	15000	29.8	1.12
222	37	MA0611.2	Dux	MA0611.2	NTGATTBAATCAVWNN	Dux	6.11e-24	1.29e-26	11700	32.2	14500	28.8	1.12
223	18	MA1991.1	Hnf1A	MA1991.1	NBCCTTTGATSTBN	Hnf1A	2.26e-23	4.76e-26	35100	96.4	47800	94.9	1.02
224	22	MA0480.2	Foxo1	MA0480.2	NDGTAAACANN	Foxo1	2.66e-23	5.58e-26	34600	95	47000	93.3	1.02
225	38	MA0606.2	Nfat5	MA0606.2	NNATGGAAAAWN	Nfat5	4.78e-23	9.97e-26	31300	85.9	42000	83.3	1.03
226	22	MA0850.1	FOXP3	MA0850.1	RTAAACA	FOXP3	7.55e-23	1.57e-25	33900	93.2	45900	91.2	1.02
227	39	MA1603.1	Dmrt1	MA1603.1	GHTACAAAGTADC	Dmrt1	9.66e-23	2e-25	22800	62.7	29800	59.2	1.06
228	40	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	1.17e-22	2.41e-25	16400	45.2	21000	41.6	1.09
229	13	MA0719.1	RHOXF1	MA0719.1	NTRATCCN	RHOXF1	1.41e-22	2.89e-25	30800	84.5	41200	81.8	1.03
230	28	MA0808.1	TEAD3	MA0808.1	RCATTCCW	TEAD3	4.39e-22	8.95e-25	15400	42.2	19500	38.8	1.09
231	32	MA0754.2	CUX1	MA0754.2	TAATCGATAM	CUX1	5.44e-22	1.1e-24	16700	45.8	21300	42.3	1.08
232	30	MA1632.1	ATF2	MA1632.1	NNATGABGTCATN	ATF2	1.65e-21	3.33e-24	24700	67.9	32500	64.6	1.05
233	41	MA0095.3	Yy1	MA0095.3	NNCAAAATGGCN	Yy1	1.74e-21	3.5e-24	33700	92.7	45700	90.8	1.02
234	3	MA1504.1	HOXC4	MA1504.1	VTMATTAN	HOXC4	3.73e-21	7.48e-24	17200	47.3	22100	43.9	1.08
235	3	MA1507.1	HOXD4	MA1507.1	VTMATTAD	HOXD4	4.37e-21	8.72e-24	11500	31.6	14300	28.4	1.11
236	13	MA0883.1	Dmbx1	MA0883.1	WDRWNMGGATTADKNNW	Dmbx1	6.37e-21	1.27e-23	18500	50.8	23900	47.4	1.07
237	42	MA1974.1	ZNF211	MA1974.1	HWYATATACCAYRYW	ZNF211	7.63e-21	1.51e-23	16900	46.3	21600	42.9	1.08
238	3	MA0715.1	PROP1	MA0715.1	TAATYWAATTA	PROP1	7.68e-21	1.51e-23	14200	39	18000	35.7	1.09
239	26	MA0043.3	HLF	MA0043.3	NNRTTATGCAACHN	HLF	1.18e-20	2.32e-23	22400	61.5	29300	58.2	1.06
240	3	MA1496.1	HOXA4	MA1496.1	RTMATTAV	HOXA4	1.48e-20	2.89e-23	15100	41.4	19200	38.1	1.09
241	36	MA0050.3	Irf1	MA0050.3	ANTGAAACTGAAASH	Irf1	2.62e-20	5.1e-23	26900	73.9	35700	70.8	1.04
242	3	MA1501.1	HOXB7	MA1501.1	GGTAATTAVS	HOXB7	6.07e-20	1.18e-22	28900	79.3	38500	76.5	1.04
243	26	MA0833.2	ATF4	MA0833.2	DDATGATGCAATMN	ATF4	8.63e-20	1.67e-22	19400	53.3	25100	49.9	1.07
244	43	MA1118.1	SIX1	MA1118.1	GWAACCTGAKM	SIX1	1.42e-19	2.73e-22	29900	82.2	40100	79.6	1.03
245	44	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	2.71e-19	5.2e-22	17300	47.4	22200	44.1	1.07
246	40	MA0774.1	MEIS2	MA0774.1	TTGACAGS	MEIS2	7.32e-19	1.4e-21	5800	15.9	6850	13.6	1.17
247	3	MA0699.1	LBX2	MA0699.1	NCYAATTARN	LBX2	1.03e-18	1.96e-21	35100	96.4	47800	95	1.01
248	3	MA1960.1	MGA::EVX1	MA1960.1	RGGTGWTAATKD	MGA::EVX1	1.23e-18	2.33e-21	21200	58.2	27700	54.9	1.06
249	22	MA0614.1	Foxj2	MA0614.1	RTAAACAA	Foxj2	2.09e-18	3.95e-21	18800	51.6	24400	48.4	1.07
250	30	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	2.51e-18	4.7e-21	14800	40.7	18900	37.6	1.08
251	4	MA0867.2	SOX4	MA0867.2	RAACAAAGRV	SOX4	3.7e-18	6.91e-21	27800	76.4	37100	73.7	1.04
252	19	MA0911.1	Hoxa11	MA0911.1	RGTCGTAAAANT	Hoxa11	4.07e-18	7.58e-21	17100	46.8	22000	43.6	1.07
253	10	MA0482.2	GATA4	MA0482.2	NNCCTTATCTNH	GATA4	5.32e-18	9.86e-21	10900	30.1	13700	27.2	1.11
254	45	MA0144.2	STAT3	MA0144.2	YTTCYKGGAAD	STAT3	7.51e-18	1.39e-20	22700	62.5	29900	59.4	1.05
255	30	MA1131.1	FOSL2::JUN	MA1131.1	GRTGACGTMAT	FOSL2::JUN	1.43e-17	2.62e-20	24900	68.5	33000	65.5	1.05
256	46	MA1479.1	DMRTC2	MA1479.1	AATTGMTACATT	DMRTC2	1.7e-17	3.12e-20	26900	73.9	35800	71.1	1.04
257	11	MA1125.1	ZNF384	MA1125.1	DNWMAAAAAAAA	ZNF384	3.65e-17	6.66e-20	17200	47.2	22200	44	1.07
258	4	MA0087.2	Sox5	MA0087.2	VRVAACAATGGNN	Sox5	4.41e-17	8.02e-20	26400	72.5	35100	69.7	1.04
259	3	MA0874.1	Arx	MA0874.1	VTBCRYTAATTARTKSW	Arx	4.91e-17	8.9e-20	12400	34	15700	31.1	1.09
260	47	MA1150.1	RORB	MA1150.1	AWWTRGGTCAH	RORB	2.2e-16	3.98e-19	34900	95.8	47500	94.4	1.01
261	11	MA0851.1	Foxj3	MA0851.1	NDAADGTAAACAAANNM	Foxj3	2.27e-16	4.07e-19	17500	48	22600	44.9	1.07
262	3	MA0887.1	EVX1	MA0887.1	VVTAATTABS	EVX1	3.44e-16	6.16e-19	34800	95.6	47400	94.2	1.01
263	8	MA1962.1	POU2F1::SOX2	MA1962.1	MATTTRCATMACAATRG	POU2F1::SOX2	3.63e-16	6.47e-19	10400	28.7	13100	26	1.1
264	11	MA0847.3	FOXD2	MA0847.3	SYTAARYAAACA	FOXD2	3.82e-16	6.78e-19	20800	57.2	27300	54.2	1.06
265	48	MA1593.1	ZNF317	MA1593.1	WVACAGCAGAYW	ZNF317	1.04e-15	1.84e-18	32400	88.9	43800	86.9	1.02
266	49	MA1523.1	MSANTD3	MA1523.1	STVCACTCAC	MSANTD3	1.05e-15	1.85e-18	31000	85.1	41700	82.8	1.03
267	46	MA1707.1	DMRTA1	MA1707.1	AWTTGWTACAWT	DMRTA1	2.03e-15	3.56e-18	27700	76	37000	73.4	1.04
268	40	MA1114.1	PBX3	MA1114.1	NNNTGAGTGACAGGBNN	PBX3	6.06e-15	1.06e-17	21000	57.7	27600	54.8	1.05
269	43	MA1119.1	SIX2	MA1119.1	NNCTGAAACCTGATMY	SIX2	7.31e-15	1.27e-17	31800	87.4	43000	85.4	1.02
270	19	MA0907.1	HOXC13	MA0907.1	BCTCGTAAAAH	HOXC13	7.6e-15	1.32e-17	16900	46.5	21900	43.6	1.07
271	19	MA0906.1	HOXC12	MA0906.1	RGTCGTAAAAH	HOXC12	2.69e-14	4.64e-17	12800	35	16300	32.3	1.08
272	10	MA0140.2	GATA1::TAL1	MA0140.2	MTTATCWSNNNNNHVCAG	GATA1::TAL1	2.69e-14	4.64e-17	10700	29.4	13500	26.8	1.1
273	36	MA0152.2	Nfatc2	MA0152.2	NNRNAATGGAAANWNH	Nfatc2	6.76e-14	1.16e-16	33800	93	46000	91.4	1.02
274	50	MA0092.1	Hand1::Tcf3	MA0092.1	BRTCTGGMWT	Hand1::Tcf3	7.85e-14	1.34e-16	18400	50.5	24000	47.6	1.06
275	30	MA1127.1	FOSB::JUN	MA1127.1	GATGACGTCAT	FOSB::JUN	1.23e-13	2.09e-16	27000	74.2	36100	71.7	1.03
276	30	MA0093.3	USF1	MA0093.3	NDGTCATGTGACHN	USF1	3.22e-13	5.48e-16	21200	58.2	27900	55.4	1.05
277	38	MA0624.2	Nfatc1	MA0624.2	NVATGGAAAAWN	Nfatc1	3.29e-13	5.58e-16	33000	90.7	44800	89	1.02
278	28	MA1121.1	TEAD2	MA1121.1	NYACATTCCWNNS	TEAD2	4.64e-13	7.84e-16	24300	66.8	32300	64.2	1.04
279	51	MA1524.2	Msgn1	MA1524.2	VRRRACAAATGGTNNN	Msgn1	5.09e-13	8.56e-16	21200	58.3	28000	55.5	1.05
280	18	MA0768.2	Lef1	MA0768.2	NNBCCTTTGATSTN	Lef1	6.13e-13	1.03e-15	15800	43.4	20500	40.7	1.07
281	3	MA0896.1	Hmx1	MA0896.1	VSVAGCAATTAAWGVDB	Hmx1	2.4e-12	4.01e-15	9450	26	11900	23.6	1.1
282	30	MA1112.2	NR4A1	MA1112.2	NNAAAGGTCANN	NR4A1	2.55e-12	4.24e-15	23700	65	31400	62.4	1.04
283	9	MA1645.1	NKX2-2	MA1645.1	NNNCCACTCAANNN	NKX2-2	2.57e-12	4.26e-15	33100	90.9	45000	89.3	1.02
284	52	MA1588.1	ZNF136	MA1588.1	RWATTCTTGGTTGRC	ZNF136	8.44e-12	1.39e-14	11400	31.4	14600	29	1.08
285	4	MA0442.2	SOX10	MA0442.2	NDAACAAAGVN	SOX10	1.88e-11	3.09e-14	18300	50.1	23900	47.6	1.05
286	30	MA1139.1	FOSL2::JUNB	MA1139.1	DATGACGTCATH	FOSL2::JUNB	4.63e-11	7.6e-14	19700	54.2	26000	51.7	1.05
287	36	MA1953.1	FOXO1::ELF1	MA1953.1	RTMAACAGGAAGTN	FOXO1::ELF1	5.4e-11	8.82e-14	31900	87.6	43300	85.9	1.02
288	22	MA0849.1	FOXO6	MA0849.1	GTAAACA	FOXO6	6.09e-11	9.93e-14	2880	7.9	3310	6.58	1.2
289	21	MA0063.2	NKX2-5	MA0063.2	NNCACTCAANN	NKX2-5	8.29e-11	1.35e-13	35500	97.4	48600	96.5	1.01
290	37	MA0884.2	DUXA	MA0884.2	YTRATTWAATYAR	DUXA	8.61e-11	1.39e-13	5960	16.4	7320	14.6	1.13
291	53	MA0596.1	SREBF2	MA0596.1	RTGGGGTGAY	SREBF2	8.75e-11	1.41e-13	7110	19.5	8840	17.6	1.11
292	12	MA0773.1	MEF2D	MA0773.1	DCTAWAAATAGM	MEF2D	1.07e-10	1.71e-13	4610	12.7	5560	11	1.15
293	54	MA1975.1	ZNF214	MA1975.1	VWTCATCAABGTCCT	ZNF214	1.08e-10	1.74e-13	22500	61.7	29800	59.2	1.04
294	45	MA1624.1	Stat5a	MA1624.1	NTTCCAAGAANH	Stat5a	1.26e-10	2.01e-13	28900	79.4	39000	77.4	1.03
295	30	MA1111.1	NR2F2	MA1111.1	NAAAGGTCANR	NR2F2	1.56e-10	2.47e-13	31200	85.8	42300	84	1.02
296	35	MA0038.2	GFI1	MA0038.2	BMAATCACDGCA	GFI1	2.1e-10	3.33e-13	6610	18.2	8200	16.3	1.12
297	15	MA0683.1	POU4F2	MA0683.1	RTGCATAATTAATGAG	POU4F2	4.32e-10	6.83e-13	6170	17	7630	15.2	1.12
298	51	MA0620.3	MITF	MA0620.3	NNNDRTCACGTGAYHNNN	MITF	9.29e-10	1.46e-12	18500	50.9	24400	48.5	1.05
299	55	MA0508.3	PRDM1	MA0508.3	YNCTTTCTCTH	PRDM1	1.72e-09	2.69e-12	28400	77.9	38200	75.9	1.03
300	9	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	2.14e-09	3.35e-12	7840	21.5	9870	19.6	1.1
301	19	MA0908.1	HOXD11	MA0908.1	RTCGTAAAAH	HOXD11	2.17e-09	3.39e-12	4940	13.6	6030	12	1.13
302	36	MA1709.1	ZIM3	MA1709.1	RVMAACAGAAACCYM	ZIM3	2.48e-09	3.85e-12	19900	54.6	26300	52.3	1.05
303	30	MA0488.1	JUN	MA0488.1	DDRATGATGTCAT	JUN	2.75e-09	4.26e-12	6060	16.6	7510	14.9	1.12
304	37	MA1720.1	ZNF85	MA1720.1	DHDGAGATTACWKCAK	ZNF85	2.84e-09	4.38e-12	22100	60.8	29400	58.4	1.04
305	46	MA1478.1	DMRTA2	MA1478.1	AATTGHTACAWT	DMRTA2	3.47e-09	5.34e-12	32300	88.6	43800	87.1	1.02
306	51	MA0698.1	ZBTB18	MA0698.1	NATCCAGATGTKB	ZBTB18	4.5e-09	6.9e-12	12300	33.9	16000	31.7	1.07
307	4	MA0515.1	Sox6	MA0515.1	CCWTTGTYYY	Sox6	6.64e-09	1.01e-11	4270	11.7	5180	10.3	1.14
308	56	MA0479.1	FOXH1	MA0479.1	BNSAATCCACA	FOXH1	9.19e-09	1.4e-11	3880	10.6	4670	9.27	1.15
309	30	MA1143.1	FOSL1::JUND	MA1143.1	RTGACGTMAY	FOSL1::JUND	1.46e-08	2.22e-11	33100	91	45200	89.7	1.02
310	47	MA1151.1	RORC	MA1151.1	NWAWNTRGGTCA	RORC	1.61e-08	2.43e-11	33100	91	45100	89.6	1.02
311	32	MA0757.1	ONECUT3	MA0757.1	AAAAAATCRATAAH	ONECUT3	1.63e-08	2.46e-11	10200	28	13100	26	1.08
312	21	MA1994.1	Nkx2-1	MA1994.1	NVCACTTGARHNN	Nkx2-1	2.68e-08	4.02e-11	34500	94.8	47200	93.8	1.01
313	57	MA0161.2 (NFIC)	STREME-4	4-TGCCTGGCACA	TGCCTGGCACA	NFIC	2.84e-08	4.26e-11	267	0.73	201	0.4	1.83
314	43	MA2001.1	Six4	MA2001.1	GDAACCTGANH	Six4	3.97e-08	5.94e-11	35400	97.3	48600	96.5	1.01
315	30	MA0631.1	Six3	MA0631.1	DATRGGGTATCAYNWNT	Six3	5.63e-08	8.39e-11	14700	40.4	19200	38.2	1.06
316	58	MA0691.1	TFAP4	MA0691.1	AWCAGCTGWT	TFAP4	1.14e-07	1.7e-10	6440	17.7	8090	16.1	1.1
317	59	MA1643.1	NFIB	MA1643.1	NNCCTGGCAYNGTGCCAAGNN	NFIB	1.6e-07	2.36e-10	1700	4.66	1910	3.79	1.23
318	60	MA1561.1	SOX12	MA1561.1	ACCGAACAATV	SOX12	2.12e-07	3.12e-10	25900	71.2	34800	69.2	1.03
319	19	MA1503.1	HOXB9	MA1503.1	GTCGTAAAAH	HOXB9	2.19e-07	3.22e-10	2290	6.29	2660	5.29	1.19
320	22	MA0040.1	Foxq1	MA0040.1	HATTGTTTATW	Foxq1	2.29e-07	3.36e-10	6320	17.4	7940	15.8	1.1
321	61	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	2.62e-07	3.83e-10	6040	16.6	7570	15	1.1
322	3	MA0468.1	DUX4	MA0468.1	TAAYYYAATCA	DUX4	3.67e-07	5.35e-10	6020	16.5	7550	15	1.1
323	61	MA0502.2	NFYB	MA0502.2	CYCATTGGCCVV	NFYB	4.22e-07	6.13e-10	1390	3.83	1540	3.06	1.25
324	51	MA0678.1	OLIG2	MA0678.1	AMCATATGKT	OLIG2	5.4e-07	7.83e-10	20700	56.8	27500	54.7	1.04
325	40	MA0775.1	MEIS3	MA0775.1	DTGACAGS	MEIS3	5.54e-07	8e-10	1800	4.94	2050	4.08	1.21
326	62	MA1980.1	ZNF418	MA1980.1	MDGAGGCTAAAAGCA	ZNF418	6.14e-07	8.84e-10	20000	54.9	26600	52.8	1.04
327	51	MA0669.1	NEUROG2	MA0669.1	RACATATGTC	NEUROG2	7.73e-07	1.11e-09	13200	36.2	17200	34.2	1.06
328	3	MA0897.1	Hmx2	MA0897.1	ASAAGCAATTAAHVVRT	Hmx2	7.85e-07	1.12e-09	7270	20	9240	18.4	1.09
329	9	MA1473.1	CDX4	MA1473.1	GGYMATAAAAC	CDX4	9.45e-07	1.35e-09	2960	8.12	3540	7.03	1.15
330	22	MA0593.1	FOXP2	MA0593.1	RWGTAAACAVR	FOXP2	1.48e-06	2.11e-09	8660	23.8	11100	22.1	1.08
331	19	MA1506.1	HOXD10	MA1506.1	RGTCGTAAAAH	HOXD10	1.69e-06	2.39e-09	5450	15	6820	13.6	1.1
332	30	MA0693.3	Vdr	MA0693.3	NNGAGTTCANN	Vdr	2.23e-06	3.16e-09	35500	97.6	48800	97	1.01
333	51	MA0461.2	Atoh1	MA0461.2	RMCATATGBY	Atoh1	2.56e-06	3.6e-09	12600	34.7	16500	32.8	1.06
334	28	MA0114.4	HNF4A	MA0114.4	DNCAAAGTCCANN	HNF4A	2.77e-06	3.89e-09	35100	96.5	48200	95.7	1.01
335	53	MA0595.1	SREBF1	MA0595.1	VTCACCCCAY	SREBF1	2.9e-06	4.07e-09	7500	20.6	9570	19	1.08
336	59	MA0119.1	NFIC::TLX1	MA0119.1	TGGCASSRWGCCAA	NFIC::TLX1	4.52e-06	6.32e-09	1570	4.32	1790	3.56	1.22
337	63	MA1124.1	ZNF24	MA1124.1	CATTCATTCATTC	ZNF24	7.2e-06	1e-08	3650	10	4470	8.88	1.13
338	28	MA0484.2	HNF4G	MA0484.2	DNCAAAGTCCANN	HNF4G	9.22e-06	1.28e-08	35100	96.4	48200	95.6	1.01
339	3	MA0135.1	Lhx3	MA0135.1	WAATTAATTAWYY	Lhx3	1.17e-05	1.62e-08	6460	17.7	8200	16.3	1.09
340	10	MA0029.1	Mecom	MA0029.1	AAGAYAAGATAANA	Mecom	1.38e-05	1.9e-08	4860	13.3	6080	12.1	1.11
341	18	MA0869.2	Sox11	MA0869.2	NRGAACAAAGVV	Sox11	1.4e-05	1.93e-08	16700	45.8	22100	43.9	1.04
342	30	MA1145.1	FOSL2::JUND	MA1145.1	NNRTGACGTCAYHSN	FOSL2::JUND	1.82e-05	2.5e-08	25200	69.2	33900	67.4	1.03
343	30	MA0492.1	JUND	MA0492.1	DDDRATGABGTCATN	JUND	2.65e-05	3.62e-08	6370	17.5	8100	16.1	1.09
344	45	MA0518.1	Stat4	MA0518.1	YTTCYRGGAARNVR	Stat4	3.16e-05	4.31e-08	19000	52.2	25300	50.3	1.04
345	64	MA0797.1	TGIF2	MA0797.1	TGACAGSTGTCA	TGIF2	5.35e-05	7.27e-08	3690	10.1	4560	9.05	1.12
346	30	MA0829.2	SREBF1	MA0829.2	DNATCACSTGATNH	SREBF1	6.05e-05	8.21e-08	17000	46.8	22600	45	1.04
347	30	MA1133.1	JUN::JUNB	MA1133.1	KRTGACGTCATN	JUN::JUNB	8.03e-05	1.09e-07	22300	61.2	29900	59.5	1.03
348	59	MA1527.1	NFIC	MA1527.1	NTTGGCDNNRTGCCARN	NFIC	9.65e-05	1.3e-07	1700	4.67	1990	3.95	1.18
349	30	MA1136.1	FOSB::JUNB	MA1136.1	RTGACGTCAT	FOSB::JUNB	0.000105	1.41e-07	23400	64.2	31400	62.5	1.03
350	47	MA0494.1	Nr1h3::Rxra	MA0494.1	TGACCTNNAGTRACCYYDN	Nr1h3::Rxra	0.000113	1.52e-07	25100	68.9	33800	67.2	1.02
351	65	MA1989.1	Bcl11B	MA1989.1	NNAAACCACAARNN	Bcl11B	0.000116	1.56e-07	27100	74.5	36700	72.9	1.02
352	36	MA1508.1	IKZF1	MA1508.1	VVAACAGGAARN	IKZF1	0.000132	1.76e-07	31300	86	42700	84.7	1.01
353	9	MA0913.2	HOXD9	MA0913.2	GYMATAAAAH	HOXD9	0.00014	1.87e-07	3060	8.42	3760	7.47	1.13
354	30	MA1126.1	FOS::JUN	MA1126.1	DRTGACGTCATHNDTN	FOS::JUN	0.000164	2.17e-07	33200	91.3	45400	90.3	1.01
355	66	MA0106.3	TP53	MA0106.3	RACATGYCCGGRCATGTY	TP53	0.000165	2.18e-07	278	0.76	246	0.49	1.56
356	67	MA0101.1	REL	MA0101.1	BGGRNWTTCC	REL	0.000174	2.29e-07	32000	87.9	43700	86.7	1.01
357	68	MA0136.3	Elf5	MA0136.3	RVAAGGAAGTNN	Elf5	0.000217	2.85e-07	35800	98.4	49300	97.9	1
358	30	MA1129.1	FOSL1::JUN	MA1129.1	ATGACGTCAT	FOSL1::JUN	0.000362	4.75e-07	23700	65.1	31900	63.4	1.03
359	3	MA0784.2	POU1F1	MA0784.2	ANCTMATTWGCATAWT	POU1F1	0.000631	8.24e-07	4870	13.4	6170	12.3	1.09
360	36	MA1952.1	FOXJ2::ELF1	MA1952.1	RTAAACMGGAAGTR	FOXJ2::ELF1	0.000663	8.63e-07	32400	88.9	44200	87.8	1.01
361	51	MA1618.1	Ptf1a	MA1618.1	NNACAGATGTTNN	Ptf1a	0.00077	1e-06	34500	94.8	47400	94.1	1.01
362	51	MA0744.2	SCRT2	MA0744.2	NNWGCAACAGGTGDNN	SCRT2	0.000789	1.02e-06	31800	87.4	43400	86.3	1.01
363	51	MA0827.1	OLIG3	MA0827.1	AMCATATGBY	OLIG3	0.000845	1.09e-06	24700	67.8	33300	66.2	1.02
364	32	MA0780.1	PAX3	MA0780.1	TAATYRATTA	PAX3	0.000922	1.19e-06	4810	13.2	6110	12.1	1.09
13	74	TTGAGSYCAGGAGTT	MEME-6	TTGAGSYCAGGAGTT	TTGAGSYCAGGAGTT	TTGAGSYCAGGAGTT	0.0011	8.47e-05	683	1.88	773	1.54	1.22
365	22	MA0030.1	FOXF2	MA0030.1	BNAASGTAAACAAD	FOXF2	0.00119	1.53e-06	4580	12.6	5800	11.5	1.09
366	59	MA1528.1	NFIX	MA1528.1	STTGGCRNNGTGCCARB	NFIX	0.00142	1.81e-06	2880	7.91	3560	7.07	1.12
367	69	MA1592.1	ZNF274	MA1592.1	NRTRTGAGTTCTCGYN	ZNF274	0.00311	3.98e-06	7670	21.1	9980	19.8	1.06
368	70	MA0520.1	Stat6	MA0520.1	BDBTTCCWSAGAAVY	Stat6	0.00419	5.34e-06	10100	27.8	13300	26.5	1.05
369	51	MA0826.1	OLIG1	MA0826.1	AMCATATGKT	OLIG1	0.00524	6.67e-06	8720	24	11400	22.7	1.06
370	26	MA0639.1	DBP	MA0639.1	NRTTACGTAAYV	DBP	0.00547	6.93e-06	6230	17.1	8050	16	1.07
371	22	MA0613.1	FOXG1	MA0613.1	RTAAACAW	FOXG1	0.00572	7.23e-06	5560	15.3	7160	14.2	1.07
372	30	MA0592.3	ESRRA	MA0592.3	NBTCAAGGTCAHN	ESRRA	0.00604	7.62e-06	33000	90.6	45200	89.7	1.01
373	58	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	0.00714	8.98e-06	5010	13.8	6420	12.8	1.08
374	18	MA1421.1	TCF7L1	MA1421.1	AAAGATCAAAGG	TCF7L1	0.00734	9.21e-06	3390	9.31	4260	8.47	1.1
375	14	MA0877.3	BARHL1	MA0877.3	AMCGTTTA	BARHL1	0.0129	1.61e-05	8070	22.2	10600	21	1.06
376	36	MA0517.1	STAT1::STAT2	MA0517.1	THAGTTTCRKTTTCY	STAT1::STAT2	0.0136	1.7e-05	17200	47.1	23000	45.7	1.03
377	57	MA0161.2	NFIC	MA0161.2	NNCTTGGCANN	NFIC	0.0164	2.04e-05	35200	96.6	48400	96.1	1.01
378	11	MA1487.2	FOXE1	MA1487.2	VYTAAAYAAACAAH	FOXE1	0.0174	2.17e-05	553	1.52	600	1.19	1.27
379	71	MA0484.2 (HNF4G)	STREME-6	6-CAAAGTGCTGGG	CAAAGTGCTGGG	HNF4G	0.0182	2.25e-05	301	0.83	297	0.59	1.4
380	30	MA1996.1	Nr1H2	MA1996.1	NNRAGGTCANN	Nr1H2	0.0195	2.41e-05	34900	96	48000	95.4	1.01
381	30	MA0629.1	Rhox11	MA0629.1	ANKNCGCTGTWAWDVRW	Rhox11	0.0204	2.51e-05	14800	40.7	19800	39.4	1.03
382	72	MA0682.2 (PITX1)	MEME-4	WGCTGGGATTACAGG	WGCTGGGATTACAGG	PITX1	0.023	2.83e-05	900	2.47	1040	2.06	1.2
383	58	MA0667.1	MYF6	MA0667.1	AACARCTGTT	MYF6	0.0357	4.37e-05	5340	14.7	6910	13.7	1.07
384	19	MA0485.2	HOXC9	MA0485.2	GTCGTAAAAH	HOXC9	0.0361	4.41e-05	3250	8.94	4120	8.18	1.09
385	45	MA1625.1	Stat5b	MA1625.1	NNNTTCCCAGAANNN	Stat5b	0.0364	4.44e-05	20200	55.6	27300	54.3	1.02
386	66	MA0525.2	TP63	MA0525.2	RACATGTYGKGACATGTC	TP63	0.0376	4.57e-05	275	0.76	271	0.54	1.4
387	73	MA0069.1	PAX6	MA0069.1	TTCACGCWTSANTK	PAX6	0.0385	4.66e-05	27900	76.6	38000	75.4	1.02
14	75	MA0090.3 (TEAD1)	MEME-5	CTGCACTCCAGCCTG	CTGCACTCCAGCCTG	TEAD1	0.105	0.00752	3540	9.72	4640	9.21	1.05
15	76	MA1596.1 (ZNF460)	MEME-7	RGAGGCWGAGGSAGG	RGAGGCWGAGGSAGG	ZNF460	0.329	0.0219	74	0.2	72	0.14	1.42
16	76	MA1653.1 (ZNF148)	MEME-3	CCCDSCCCCKCCYCC	CCCDSCCCCKCCYCC	ZNF148	5.87	0.367	142	0.39	188	0.37	1.05

ER_rat <- 1.25

EPI_24_20kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("EPI_24_20kb_combo response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

EPI_24_20kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*9), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./9,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("EPI_24_20kb_combo response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DNR

DNR_DAR_3hr data

DNR_DAR_3hr_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_3_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DNR_DAR_3hr_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_3_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DNR_DAR_3hr_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_3_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DNR_DAR_3hr_all <- rbind(DNR_DAR_3hr_sea_disc, DNR_DAR_3hr_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DNR_DAR_3hr_combo <- DNR_DAR_3hr_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DNR_DAR_3hr_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ NA_character_
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="DNR_DAR_3hr")

DNR_DAR_3hr_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs in 3 hour DNR-DAR v 3 hour non-DNR DAR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs in 3 hour DNR-DAR v 3 hour non-DNR DAR
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA0079.5 (SP1)	MEME-1	CSCSSSCSCCGSCSC	CSCSSSCSCCGSCSC	SP1	0	0	9080	44.4	30800	25.8	1.72	DNR_DAR_3hr
2	1	MA0162.4 (EGR1)	STREME-1	1-CCGCCCCCGCCCCS	CCGCCCCCGCCCCS	EGR1	0	0	6270	30.6	17900	14.9	2.05	DNR_DAR_3hr
3	2	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	0	0	7060	34.5	22400	18.8	1.84	DNR_DAR_3hr
4	2	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	0	0	6710	32.8	21000	17.6	1.87	DNR_DAR_3hr
5	2	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	0	0	8030	39.2	27400	22.9	1.71	DNR_DAR_3hr
6	2	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	0	0	10400	50.7	39700	33.2	1.53	DNR_DAR_3hr
7	3	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	0	0	7890	38.5	27000	22.6	1.71	DNR_DAR_3hr
8	3	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	0	0	6870	33.6	22300	18.6	1.8	DNR_DAR_3hr
9	2	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	0	0	8930	43.6	32700	27.4	1.6	DNR_DAR_3hr
10	4	2-CSCGSG	STREME-2	2-CSCGSG	CSCGSG	CSCGSG	0	0	10500	51.5	41800	34.9	1.47	DNR_DAR_3hr
11	2	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	0	0	7460	36.5	25800	21.6	1.69	DNR_DAR_3hr
12	5	MA1713.1 (ZNF610)	STREME-4	4-CGCTCCCC	CGCTCCCC	ZNF610	0	0	11000	53.5	44100	36.9	1.45	DNR_DAR_3hr
13	2	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	0	0	12200	59.8	51700	43.3	1.38	DNR_DAR_3hr
14	2	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	0	0	8980	43.9	33900	28.4	1.54	DNR_DAR_3hr
15	2	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	0	0	11400	55.8	47300	39.6	1.41	DNR_DAR_3hr
16	6	6-CCCCSA	STREME-6	6-CCCCSA	CCCCSA	CCCCSA	0	0	9640	47.1	37500	31.4	1.5	DNR_DAR_3hr
17	2	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	0	0	11500	56.4	48100	40.3	1.4	DNR_DAR_3hr
18	2	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	0	0	8640	42.2	32400	27.1	1.56	DNR_DAR_3hr
19	7	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	0	0	6330	30.9	21200	17.7	1.75	DNR_DAR_3hr
20	8	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	0	0	8800	43	33500	28	1.53	DNR_DAR_3hr
21	9	14-CKSSMG	STREME-14	14-CKSSMG	14-CKSSMG	CKSSMG	0	0	7020	34.3	24600	20.6	1.67	DNR_DAR_3hr
22	3	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	0	0	10200	50	41400	34.6	1.44	DNR_DAR_3hr
23	10	3-RGCCGS	STREME-3	3-RGCCGS	RGCCGS	RGCCGS	0	0	7730	37.8	28200	23.6	1.6	DNR_DAR_3hr
24	2	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	0	0	11700	57.4	49900	41.8	1.37	DNR_DAR_3hr
25	2	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	0	0	11000	53.7	45700	38.2	1.41	DNR_DAR_3hr
26	3	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	0	0	8980	43.9	34800	29.1	1.51	DNR_DAR_3hr
27	2	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	0	0	12000	58.7	51800	43.3	1.35	DNR_DAR_3hr
28	11	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	0	0	8520	41.6	32600	27.2	1.53	DNR_DAR_3hr
29	2	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	0	0	11700	56.9	49900	41.8	1.36	DNR_DAR_3hr
30	2	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	0	0	7760	37.9	28800	24.1	1.57	DNR_DAR_3hr
31	2	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	0	0	11800	57.7	50900	42.6	1.36	DNR_DAR_3hr
32	2	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	0	0	7740	37.8	28700	24	1.57	DNR_DAR_3hr
33	12	MA1596.1 (ZNF460)	STREME-5	5-GCGGAGG	GCGGAGG	ZNF460	0	0	7720	37.7	28700	24	1.57	DNR_DAR_3hr
34	13	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	0	0	8120	39.7	30900	25.9	1.53	DNR_DAR_3hr
35	14	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	0	0	9180	44.9	36500	30.6	1.47	DNR_DAR_3hr
36	3	MA0732.1	EGR3	MA0732.1	HHMCGCCCACGCAHH	EGR3	0	0	6130	30	21100	17.6	1.7	DNR_DAR_3hr
37	2	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	0	0	9040	44.2	35800	30	1.47	DNR_DAR_3hr
38	2	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	0	0	10200	50.1	42400	35.5	1.41	DNR_DAR_3hr
39	15	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	0	0	9510	46.5	38500	32.2	1.44	DNR_DAR_3hr
40	79	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	0	0	10900	53.5	46400	38.8	1.38	DNR_DAR_3hr
41	2	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	0	0	8960	43.8	35500	29.7	1.47	DNR_DAR_3hr
42	16	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	0	0	7290	35.6	26900	22.5	1.58	DNR_DAR_3hr
43	2	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	0	0	10200	49.7	42100	35.2	1.41	DNR_DAR_3hr
44	17	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	0	0	7780	38	29400	24.6	1.55	DNR_DAR_3hr
45	18	MA0506.2 (Nrf1)	STREME-16	16-CWGCGS	16-CWGCGS	Nrf1	0	0	8090	39.5	31100	26	1.52	DNR_DAR_3hr
46	3	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	2.9e-308	3.90999999999998e-310	8920	43.6	35900	30	1.45	DNR_DAR_3hr
47	19	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	3.05e-304	4.03e-306	8260	40.4	32500	27.2	1.49	DNR_DAR_3hr
48	2	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	1.46e-302	1.89e-304	9480	46.3	39000	32.6	1.42	DNR_DAR_3hr
49	2	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	2.76e-297	3.49e-299	8300	40.5	32800	27.5	1.48	DNR_DAR_3hr
50	20	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	3.47e-296	4.31e-298	10400	50.6	44000	36.8	1.37	DNR_DAR_3hr
51	21	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	9.8e-292	1.19e-293	10400	51	44600	37.3	1.37	DNR_DAR_3hr
52	22	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	7.74e-291	9.23999999999999e-293	10300	50.2	43700	36.5	1.37	DNR_DAR_3hr
53	16	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	3.65e-284	4.28e-286	9870	48.2	41600	34.8	1.38	DNR_DAR_3hr
54	23	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	7.26e-282	8.35e-284	6420	31.4	23600	19.7	1.59	DNR_DAR_3hr
55	16	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	4.7e-280	5.3e-282	9240	45.2	38300	32.1	1.41	DNR_DAR_3hr
56	2	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	3.83e-278	4.25e-280	10000	48.9	42600	35.6	1.37	DNR_DAR_3hr
57	2	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	1.42e-274	1.55e-276	9730	47.6	41100	34.4	1.38	DNR_DAR_3hr
58	24	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	2.09e-271	2.24e-273	8820	43.1	36300	30.4	1.42	DNR_DAR_3hr
59	25	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	1.15e-261	1.21e-263	11400	55.6	50800	42.5	1.31	DNR_DAR_3hr
60	26	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	5.6e-259	5.8e-261	8420	41.2	34500	28.8	1.43	DNR_DAR_3hr
61	27	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	1.71e-257	1.74e-259	9980	48.8	43000	36	1.36	DNR_DAR_3hr
62	23	MA0024.3	E2F1	MA0024.3	TTTGGCGCCAAA	E2F1	4.32e-254	4.32e-256	6630	32.4	25300	21.2	1.53	DNR_DAR_3hr
63	28	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	1.6e-242	1.58e-244	10100	49.6	44400	37.1	1.34	DNR_DAR_3hr
64	29	MA1712.1 (ZNF454)	STREME-10	10-CCAGGGCC	10-CCAGGGCC	ZNF454	2e-237	1.94e-239	9450	46.2	40600	34	1.36	DNR_DAR_3hr
65	23	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	1.53e-235	1.46e-237	5910	28.9	22100	18.5	1.56	DNR_DAR_3hr
66	15	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	1.03e-232	9.70999999999999e-235	7700	37.6	31300	26.2	1.43	DNR_DAR_3hr
67	30	MA1578.1	VEZF1	MA1578.1	CCCCCCMYDH	VEZF1	7.94e-229	7.36e-231	6660	32.6	26100	21.8	1.49	DNR_DAR_3hr
68	31	MA0597.2	THAP1	MA0597.2	VSGCAGGGCASV	THAP1	1.22e-225	1.11e-227	11200	54.9	51100	42.7	1.28	DNR_DAR_3hr
69	15	MA1569.1	TFAP2E	MA1569.1	YGCCYSRGGCD	TFAP2E	1.06e-224	9.5e-227	4640	22.7	16200	13.6	1.67	DNR_DAR_3hr
70	11	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	2.73e-224	2.42e-226	4700	23	16500	13.8	1.66	DNR_DAR_3hr
71	32	MA1517.1 (KLF6)	STREME-11	11-CACSCMC	11-CACSCMC	KLF6	7.63e-223	6.67e-225	13800	67.4	66500	55.6	1.21	DNR_DAR_3hr
72	33	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	7.4e-218	6.38e-220	10600	51.7	47600	39.8	1.3	DNR_DAR_3hr
73	17	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	2.12e-215	1.8e-217	10400	50.8	46500	38.9	1.3	DNR_DAR_3hr
74	34	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	3.04e-214	2.55e-216	10400	50.8	46600	39	1.3	DNR_DAR_3hr
75	2	MA0528.2	ZNF263	MA0528.2	VNGGGGAGGASG	ZNF263	3.28e-213	2.72e-215	6510	31.8	25700	21.5	1.48	DNR_DAR_3hr
76	35	MA1727.1	ZNF417	MA1727.1	VRBVNTGGGCGCCAM	ZNF417	3e-212	2.45e-214	6980	34.1	28100	23.5	1.45	DNR_DAR_3hr
77	23	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	1.61e-210	1.3e-212	8360	40.8	35500	29.7	1.38	DNR_DAR_3hr
78	36	MA0751.1	ZIC4	MA0751.1	GRCCCCCCGCKGYGH	ZIC4	9.18e-210	7.31e-212	11000	53.8	50300	42.1	1.28	DNR_DAR_3hr
79	34	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	4.96e-206	3.9e-208	5060	24.7	18700	15.6	1.58	DNR_DAR_3hr
80	15	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	6.52e-205	5.06e-207	12000	58.8	56400	47.2	1.25	DNR_DAR_3hr
81	16	MA0872.1	TFAP2A	MA0872.1	TGCCCYSRGGGCA	TFAP2A	7.14e-202	5.47e-204	6000	29.3	23400	19.6	1.5	DNR_DAR_3hr
82	37	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	2.9e-199	2.2e-201	6350	31	25300	21.1	1.47	DNR_DAR_3hr
83	16	MA0815.1	TFAP2C	MA0815.1	TGCCCYSRGGGCA	TFAP2C	7.93e-196	5.93e-198	5060	24.7	18900	15.8	1.57	DNR_DAR_3hr
84	30	MA0736.1	GLIS2	MA0736.1	GACCCCCCGCRAMG	GLIS2	9.25e-195	6.84e-197	6740	32.9	27400	22.9	1.44	DNR_DAR_3hr
85	38	MA1985.1	ZNF669	MA1985.1	GGGGYGAYGACCRCT	ZNF669	4.62e-193	3.38e-195	8120	39.7	34700	29.1	1.37	DNR_DAR_3hr
86	16	MA0813.1	TFAP2B	MA0813.1	TGCCCYBRGGGCA	TFAP2B	6.53e-192	4.71e-194	5490	26.8	21100	17.7	1.52	DNR_DAR_3hr
87	34	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	2.82e-191	2.01e-193	6180	30.2	24600	20.6	1.47	DNR_DAR_3hr
88	2	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	1.05e-189	7.38e-192	6230	30.4	24900	20.8	1.46	DNR_DAR_3hr
89	39	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	2.42e-187	1.69e-189	9120	44.6	40400	33.8	1.32	DNR_DAR_3hr
90	34	MA1631.1	ASCL1	MA1631.1	NNGCACCTGCYNB	ASCL1	1.58e-183	1.09e-185	13000	63.7	63100	52.8	1.21	DNR_DAR_3hr
91	40	MA0615.1	Gmeb1	MA0615.1	BHBBKKACGTMMNWNNN	Gmeb1	7.13e-180	4.86e-182	6890	33.7	28600	24	1.41	DNR_DAR_3hr
92	36	MA1584.1	ZIC5	MA1584.1	VGACCCCCCGCTGHGM	ZIC5	2.48e-177	1.67e-179	4910	24	18600	15.6	1.54	DNR_DAR_3hr
93	34	MA0522.3	TCF3	MA0522.3	NVCACCTGCNN	TCF3	6.92e-175	4.62e-177	14800	72.3	74300	62.2	1.16	DNR_DAR_3hr
94	41	MA1966.1	TFAP4::ETV1	MA1966.1	RSCGGAAGCAGSTGKN	TFAP4::ETV1	1.86e-174	1.23e-176	4870	23.8	18500	15.5	1.54	DNR_DAR_3hr
95	23	MA0470.2	E2F4	MA0470.2	TTTTGGCGCCAWWW	E2F4	1.39e-173	9.06e-176	5340	26.1	20800	17.4	1.5	DNR_DAR_3hr
96	37	MA0750.2	ZBTB7A	MA0750.2	NVCCGGAAGTGSV	ZBTB7A	1.71e-173	1.11e-175	4850	23.7	18400	15.4	1.54	DNR_DAR_3hr
97	23	MA0864.2	E2F2	MA0864.2	RWTTTGGCGCCAWWWY	E2F2	4.97e-167	3.18e-169	4240	20.7	15600	13	1.59	DNR_DAR_3hr
98	36	MA0696.1	ZIC1	MA0696.1	GACCCCCYGCTGTG	ZIC1	3.33e-163	2.11e-165	6010	29.4	24500	20.5	1.43	DNR_DAR_3hr
99	30	MA1987.1	ZNF701	MA1987.1	GAGCACYAARGGGGGRADDDD	ZNF701	5.94e-163	3.73e-165	11900	58.4	57400	48	1.22	DNR_DAR_3hr
100	33	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	2.31e-162	1.43e-164	14200	69.5	71200	59.5	1.17	DNR_DAR_3hr
101	41	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	3.29e-162	2.02e-164	9250	45.2	42000	35.1	1.29	DNR_DAR_3hr
102	42	MA1719.1	ZNF816	MA1719.1	DRRKGGGGACATGCHGGG	ZNF816	4.02e-161	2.44e-163	14100	68.7	70200	58.7	1.17	DNR_DAR_3hr
103	34	MA1106.1	HIF1A	MA1106.1	SBACGTGCNN	HIF1A	1.3e-155	7.82e-158	7960	38.9	35100	29.4	1.32	DNR_DAR_3hr
104	41	MA1941.1	ETV2::FIGLA	MA1941.1	RSCGGAARCAGSTGBN	ETV2::FIGLA	8.4e-155	5.02e-157	6580	32.1	27800	23.2	1.38	DNR_DAR_3hr
105	34	MA1648.1	TCF12	MA1648.1	NNCACCTGCNN	TCF12	1.46e-154	8.65e-157	16600	81.3	86800	72.6	1.12	DNR_DAR_3hr
106	33	MA0694.1	ZBTB7B	MA0694.1	RCGACCACCGAA	ZBTB7B	1.36e-153	7.96e-156	9970	48.7	46300	38.8	1.26	DNR_DAR_3hr
107	43	MA0146.2 (Zfx)	STREME-9	9-CCCAGGCC	CCCAGGCC	Zfx	2.87e-153	1.67e-155	6900	33.7	29500	24.7	1.37	DNR_DAR_3hr
108	34	MA1945.1	ETV5::FIGLA	MA1945.1	RGCGGAARCAGGTGG	ETV5::FIGLA	8.6e-152	4.95e-154	10000	49.1	46800	39.2	1.25	DNR_DAR_3hr
109	34	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	1.59e-151	9.03e-154	16300	79.7	84800	70.9	1.12	DNR_DAR_3hr
110	34	MA0147.3	MYC	MA0147.3	NNCCACGTGCNB	MYC	1.79e-147	1.01e-149	12800	62.4	62900	52.6	1.19	DNR_DAR_3hr
111	34	MA1099.2	HES1	MA1099.2	GGCRCGTGBC	HES1	1e-144	5.59e-147	4050	19.8	15200	12.7	1.55	DNR_DAR_3hr
112	34	MA0616.2	HES2	MA0616.2	GGCACGTGYC	HES2	2.11e-144	1.17e-146	8500	41.5	38500	32.2	1.29	DNR_DAR_3hr
113	44	MA1628.1	Zic1::Zic2	MA1628.1	CVCAGCAGGNV	Zic1::Zic2	2.87e-144	1.58e-146	8570	41.9	38800	32.5	1.29	DNR_DAR_3hr
114	22	MA1929.1	CTCF	MA1929.1	CTGCAGTKCCNNNNNYNRCCASYAGRKGGCRSWG	CTCF	1.93e-140	1.05e-142	9480	46.3	44000	36.8	1.26	DNR_DAR_3hr
115	33	MA0695.1	ZBTB7C	MA0695.1	RCGACCACCGAN	ZBTB7C	4.24e-139	2.29e-141	9940	48.6	46700	39.1	1.24	DNR_DAR_3hr
116	14	MA1587.1	ZNF135	MA1587.1	CCTCGACCTCCYRR	ZNF135	6.87e-137	3.68e-139	10300	50.1	48600	40.7	1.23	DNR_DAR_3hr
117	41	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	4.96e-136	2.63e-138	8940	43.7	41200	34.5	1.27	DNR_DAR_3hr
118	22	MA0155.1	INSM1	MA0155.1	TGYCWGGGGGCR	INSM1	2.63e-135	1.38e-137	6030	29.5	25500	21.4	1.38	DNR_DAR_3hr
119	41	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	4.28e-132	2.23e-134	8390	41	38400	32.1	1.28	DNR_DAR_3hr
120	41	MA1684.1	Foxn1	MA1684.1	RGAMGC	Foxn1	2.37e-127	1.23e-129	3080	15	11000	9.23	1.63	DNR_DAR_3hr
121	45	MA1522.1 (MAZ)	STREME-8	8-CCCCCCTC	CCCCCCTC	MAZ	1.28e-119	6.54e-122	6480	31.7	28500	23.8	1.33	DNR_DAR_3hr
122	34	MA0104.4	MYCN	MA0104.4	VVCCACGTGGBB	MYCN	2.61e-119	1.33e-121	13400	65.6	68100	57	1.15	DNR_DAR_3hr
123	46	MA1710.1	ZNF257	MA1710.1	VDGAGGCRAGRG	ZNF257	5.37e-118	2.71e-120	10400	50.8	50200	42	1.21	DNR_DAR_3hr
124	47	MA1637.1	EBF3	MA1637.1	NYCCCAAGGGANN	EBF3	1.16e-116	5.79e-119	13300	65.2	67600	56.6	1.15	DNR_DAR_3hr
125	34	MA0649.1	HEY2	MA0649.1	GRCACGTGYC	HEY2	2.22e-116	1.1e-118	5490	26.8	23300	19.5	1.37	DNR_DAR_3hr
126	48	MA0767.1	GCM2	MA0767.1	BATGCGGGTR	GCM2	1.12e-115	5.51e-118	10400	50.7	50200	42	1.21	DNR_DAR_3hr
127	17	MA1930.1	CTCF	MA1930.1	CTGCAGTKCCNVCHNNYRGCCASYAGRKGGCRAKC	CTCF	2.79e-113	1.36e-115	7140	34.9	32200	27	1.29	DNR_DAR_3hr
128	49	MA1982.1	ZNF574	MA1982.1	VGSCTAGAGMGGCCS	ZNF574	3.76e-113	1.82e-115	8860	43.3	41700	34.9	1.24	DNR_DAR_3hr
129	50	MA1973.1	ZKSCAN3	MA1973.1	KDKCCCAGGCTAGCCCABNN	ZKSCAN3	2.51e-112	1.21e-114	9790	47.8	47000	39.3	1.22	DNR_DAR_3hr
130	34	MA1474.1	CREB3L4	MA1474.1	YGCCACGTCAYC	CREB3L4	2.08e-109	9.91e-112	6700	32.7	30000	25.1	1.3	DNR_DAR_3hr
131	51	MA1528.1	NFIX	MA1528.1	STTGGCRNNGTGCCARB	NFIX	3.5e-109	1.66e-111	5440	26.6	23300	19.5	1.36	DNR_DAR_3hr
132	3	MA1656.1	ZNF449	MA1656.1	NNAAGCCCAACCNN	ZNF449	4.2e-108	1.98e-110	15700	76.6	82500	69	1.11	DNR_DAR_3hr
133	52	MA1728.1	ZNF549	MA1728.1	NNTGCTGCCCWR	ZNF549	7.5e-108	3.5e-110	8190	40	38200	32	1.25	DNR_DAR_3hr
134	39	MA0067.2	PAX2	MA0067.2	BCAVTSRAGCGTGACGR	PAX2	6.62e-106	3.07e-108	7170	35	32700	27.3	1.28	DNR_DAR_3hr
135	53	MA0145.2	Tfcp2l1	MA0145.2	CCAGYYYVADCCRG	Tfcp2l1	5.02e-103	2.31e-105	10600	51.6	51800	43.3	1.19	DNR_DAR_3hr
136	36	MA0697.2	Zic3	MA0697.2	CNCAGCAGGAGNN	Zic3	1.49e-102	6.82e-105	9540	46.6	46000	38.5	1.21	DNR_DAR_3hr
137	54	MA1972.1	ZFP14	MA1972.1	GGAGGCHCHGGARBG	ZFP14	2.8e-102	1.27e-104	12300	59.9	61800	51.7	1.16	DNR_DAR_3hr
138	55	MA1716.1	ZNF76	MA1716.1	NNTWCCCAYAATGCAHYGCGC	ZNF76	8.11e-102	3.65e-104	6900	33.7	31400	26.2	1.28	DNR_DAR_3hr
139	25	MA0006.1	Ahr::Arnt	MA0006.1	YGCGTG	Ahr::Arnt	1.55e-101	6.91e-104	3620	17.7	14300	12	1.48	DNR_DAR_3hr
140	34	MA0103.3	ZEB1	MA0103.3	SNCACCTGSVN	ZEB1	1.81e-101	8.03e-104	13500	65.9	69200	57.9	1.14	DNR_DAR_3hr
141	34	MA0259.1	ARNT::HIF1A	MA0259.1	VBACGTGC	ARNT::HIF1A	8.71e-100	3.83e-102	5020	24.5	21500	18	1.36	DNR_DAR_3hr
142	56	MA1730.1	ZNF708	MA1730.1	NNRGCTGTRCCTCCY	ZNF708	6.49e-99	2.84e-101	11000	53.8	54700	45.7	1.18	DNR_DAR_3hr
143	57	MA0504.1	NR2C2	MA0504.1	VGRGGTCARAGGTCA	NR2C2	1.6e-98	6.95e-101	9670	47.2	46900	39.2	1.2	DNR_DAR_3hr
144	37	MA0765.3	ETV5	MA0765.3	ACCGGAAGTR	ETV5	3.33e-97	1.43e-99	6480	31.6	29300	24.5	1.29	DNR_DAR_3hr
145	58	MA1149.1	RARA::RXRG	MA1149.1	RRGGTCAHNNNRRGGTCA	RARA::RXRG	1.45e-95	6.21e-98	12700	62.1	64800	54.2	1.15	DNR_DAR_3hr
146	34	MA1560.1	SOHLH2	MA1560.1	YGCACGTGCN	SOHLH2	2.04e-93	8.66e-96	8550	41.8	40900	34.2	1.22	DNR_DAR_3hr
147	51	MA1643.1	NFIB	MA1643.1	NNCCTGGCAYNGTGCCAAGNN	NFIB	2.31e-93	9.74e-96	7850	38.4	37000	30.9	1.24	DNR_DAR_3hr
148	37	MA0764.3	ETV4	MA0764.3	ACCGGAAGTR	ETV4	1.4e-92	5.89e-95	5830	28.5	26000	21.8	1.31	DNR_DAR_3hr
149	47	MA0154.4	EBF1	MA0154.4	NNTCCCCAGGGGANN	EBF1	2.43e-88	1.01e-90	9530	46.6	46600	39	1.19	DNR_DAR_3hr
150	41	MA1635.1	BHLHE22	MA1635.1	NVCAGCTGBN	BHLHE22	1.31e-86	5.42e-89	9030	44.1	43900	36.7	1.2	DNR_DAR_3hr
151	36	MA1629.1	Zic2	MA1629.1	NDCACAGCAGGDRG	Zic2	8.35e-85	3.43e-87	13200	64.3	68100	57	1.13	DNR_DAR_3hr
152	59	MA1964.1	SMAD2	MA1964.1	NBCCAGACDN	SMAD2	4.03e-84	1.65e-86	12900	63.1	66700	55.8	1.13	DNR_DAR_3hr
153	17	MA0163.1	PLAG1	MA0163.1	GGGGCCCWAGGGGG	PLAG1	4.51e-82	1.83e-84	3080	15	12200	10.2	1.47	DNR_DAR_3hr
154	47	MA1604.1	Ebf2	MA1604.1	NYCCCAAGGGANN	Ebf2	1.67e-79	6.72e-82	14600	71.4	77200	64.6	1.11	DNR_DAR_3hr
155	60	MA1726.1	ZNF331	MA1726.1	NMYTGCAGAGCCCH	ZNF331	4.55e-79	1.82e-81	10200	49.9	51100	42.7	1.17	DNR_DAR_3hr
156	34	MA0464.2	BHLHE40	MA0464.2	VKCACGTGMC	BHLHE40	7.8e-79	3.1e-81	9490	46.4	46900	39.2	1.18	DNR_DAR_3hr
157	48	MA0646.1	GCM1	MA0646.1	BATGCGGGTAC	GCM1	3.75e-78	1.48e-80	6570	32.1	30700	25.6	1.25	DNR_DAR_3hr
158	34	MA1464.1	ARNT2	MA1464.1	GTCACGTGMN	ARNT2	4.21e-77	1.65e-79	8130	39.8	39300	32.9	1.21	DNR_DAR_3hr
159	61	MA1971.1	ZBED2	MA1971.1	NNMMCGAAACCNNV	ZBED2	2.7e-75	1.05e-77	1980	9.69	7180	6	1.61	DNR_DAR_3hr
160	15	MA1581.1	ZBTB6	MA1581.1	DNSCTTGAGCCNV	ZBTB6	1.26e-73	4.88e-76	10300	50.2	51700	43.2	1.16	DNR_DAR_3hr
161	62	MA1711.1	ZNF343	MA1711.1	CCGCTTCMCCDCGGCMV	ZNF343	1.05e-71	4.06e-74	3630	17.8	15400	12.9	1.38	DNR_DAR_3hr
162	34	MA0499.2	MYOD1	MA0499.2	NNGCACCTGTCNB	MYOD1	4.7e-71	1.8e-73	15500	75.9	83300	69.7	1.09	DNR_DAR_3hr
163	63	MA1575.1	THRB	MA1575.1	DTGACCTBRNYVAGGTCAH	THRB	4.12e-70	1.57e-72	4100	20	17800	14.9	1.34	DNR_DAR_3hr
164	22	MA0139.1	CTCF	MA0139.1	YGRCCASYAGRKGGCRSYR	CTCF	3.79e-68	1.44e-70	11700	57	60200	50.3	1.13	DNR_DAR_3hr
165	64	MA1545.1	OVOL2	MA1545.1	DDACCGTTABNYN	OVOL2	6.33e-68	2.38e-70	3750	18.3	16100	13.5	1.36	DNR_DAR_3hr
166	63	MA1533.1	NR1I2	MA1533.1	DYGAACTSVDTGAACTC	NR1I2	8.61e-66	3.22e-68	11900	58.4	61900	51.8	1.13	DNR_DAR_3hr
167	37	MA0028.2	ELK1	MA0028.2	ACCGGAAGTR	ELK1	9.22e-64	3.43e-66	7990	39.1	39300	32.8	1.19	DNR_DAR_3hr
168	41	MA0048.2	NHLH1	MA0048.2	CGCAGCTGCK	NHLH1	1.04e-61	3.86e-64	13200	64.6	69800	58.4	1.11	DNR_DAR_3hr
169	65	MA0511.2	RUNX2	MA0511.2	WAACCGCAA	RUNX2	2.39e-61	8.76e-64	15200	74.4	82100	68.6	1.08	DNR_DAR_3hr
170	66	MA1979.1	ZNF416	MA1979.1	TATCTGGGCAH	ZNF416	1.09e-60	3.98e-63	15600	76.1	84100	70.4	1.08	DNR_DAR_3hr
171	67	MA1652.1	ZKSCAN5	MA1652.1	NNRGGARGTGAGRR	ZKSCAN5	2.47e-59	8.95e-62	12200	59.5	63600	53.2	1.12	DNR_DAR_3hr
172	68	MA1475.1	CREB3L4	MA1475.1	GRTGACGTCAYC	CREB3L4	1.21e-55	4.37e-58	3830	18.7	17100	14.3	1.31	DNR_DAR_3hr
173	37	MA1933.1	ELK1::SREBF2	MA1933.1	DCCGGAAGTSRCGTGA	ELK1::SREBF2	9.6e-55	3.44e-57	1700	8.29	6380	5.33	1.56	DNR_DAR_3hr
174	69	MA1731.1	ZNF768	MA1731.1	YBVCYBRSCCTCTCTGDG	ZNF768	4.47e-54	1.59e-56	10100	49.2	51600	43.2	1.14	DNR_DAR_3hr
175	37	MA0156.3	FEV	MA0156.3	VACCGGAAGTVV	FEV	4.32e-51	1.53e-53	6540	32	31900	26.7	1.2	DNR_DAR_3hr
176	41	MA1529.1	NHLH2	MA1529.1	GGGNCGCAGCTGCGYCCC	NHLH2	4.6e-51	1.62e-53	5140	25.1	24300	20.3	1.24	DNR_DAR_3hr
177	70	MA0138.2	REST	MA0138.2	TTCAGCACCATGGACAGCDCC	REST	1.91e-49	6.7e-52	4220	20.6	19400	16.2	1.27	DNR_DAR_3hr
178	34	MA1934.1	ERF::FIGLA	MA1934.1	RCCGGAARCASCTGBN	ERF::FIGLA	4.36e-49	1.52e-51	3000	14.7	13000	10.9	1.34	DNR_DAR_3hr
179	34	MA1100.2	ASCL1	MA1100.2	VGCAGCTGCN	ASCL1	1.04e-48	3.59e-51	17400	85.1	96600	80.8	1.05	DNR_DAR_3hr
180	71	MA2002.1	Zfp335	MA2002.1	VNTCAGGCANH	Zfp335	9.11e-48	3.14e-50	7850	38.3	39400	33	1.16	DNR_DAR_3hr
181	41	MA1485.1	FERD3L	MA1485.1	GCRMCAGCTGTYAC	FERD3L	5.03e-47	1.73e-49	4670	22.8	21900	18.4	1.24	DNR_DAR_3hr
182	72	MA1557.1	SMAD5	MA1557.1	YGTCTAGACA	SMAD5	5.49e-46	1.87e-48	11300	55	59100	49.5	1.11	DNR_DAR_3hr
183	73	MA0738.1	HIC2	MA0738.1	RTGCCCRSB	HIC2	1.42e-45	4.81e-48	3910	19.1	17900	15	1.27	DNR_DAR_3hr
184	74	MA1108.2 (MXI1)	STREME-7	7-CACACATG	CACACATG	MXI1	1.03e-43	3.48e-46	1430	6.97	5410	4.52	1.54	DNR_DAR_3hr
185	58	MA0159.1	RARA::RXRA	MA0159.1	RGKTCANVGRSAGGTCA	RARA::RXRA	1.21e-41	4.06e-44	7630	37.3	38600	32.3	1.16	DNR_DAR_3hr
186	34	MA1493.1	HES6	MA1493.1	GGCACGTGTY	HES6	2.22e-41	7.4e-44	13600	66.7	73700	61.6	1.08	DNR_DAR_3hr
187	75	MA0778.1	NFKB2	MA0778.1	AGGGGAWTCCCCY	NFKB2	6.44e-41	2.14e-43	3540	17.3	16200	13.6	1.28	DNR_DAR_3hr
188	34	MA0608.1	Creb3l2	MA0608.1	GCCACGTGD	Creb3l2	1.07e-40	3.54e-43	2480	12.1	10700	8.95	1.35	DNR_DAR_3hr
189	76	MA1715.1	ZNF707	MA1715.1	CCCCACTCCTGGTAC	ZNF707	4.26e-40	1.4e-42	7990	39.1	40700	34.1	1.15	DNR_DAR_3hr
190	34	MA0822.1	HES7	MA0822.1	YGGCACGTGCCR	HES7	9.7e-40	3.17e-42	1380	6.74	5300	4.43	1.52	DNR_DAR_3hr
191	34	MA0745.2	SNAI2	MA0745.2	NBGCACCTGTMNY	SNAI2	1.32e-39	4.3e-42	16800	82.1	93100	77.9	1.05	DNR_DAR_3hr
192	37	MA0076.2	ELK4	MA0076.2	BCRCTTCCGGB	ELK4	7.8e-39	2.52e-41	893	4.36	3060	2.56	1.7	DNR_DAR_3hr
193	34	MA0004.1	Arnt	MA0004.1	CACGTG	Arnt	5.68e-38	1.83e-40	4180	20.4	19800	16.5	1.23	DNR_DAR_3hr
194	77	MA0863.1	MTF1	MA0863.1	TTTGCACACGGCAC	MTF1	9.45e-37	3.02e-39	2860	14	12900	10.8	1.3	DNR_DAR_3hr
195	57	MA1147.1	NR4A2::RXRA	MA1147.1	VRGGTCRTTGACCYY	NR4A2::RXRA	1.19e-36	3.8e-39	9720	47.5	50900	42.6	1.12	DNR_DAR_3hr
196	41	MA0500.2	MYOG	MA0500.2	NDRCAGCTGYHN	MYOG	2.06e-36	6.52e-39	12800	62.7	69200	57.9	1.08	DNR_DAR_3hr
197	34	MA0603.1	Arntl	MA0603.1	NGTCACGTGH	Arntl	4.13e-36	1.3e-38	6120	29.9	30500	25.5	1.17	DNR_DAR_3hr
198	78	MA0807.1	TBX5	MA0807.1	AGGTGTKA	TBX5	4.45e-35	1.4e-37	13200	64.6	71600	59.9	1.08	DNR_DAR_3hr
199	30	MA0737.1	GLIS3	MA0737.1	GACCCCCCACGAAG	GLIS3	5.47e-35	1.71e-37	1700	8.29	7000	5.85	1.42	DNR_DAR_3hr
200	37	MA1938.1	ERF::NHLH1	MA1938.1	VGCAGCTGCCGGAARYN	ERF::NHLH1	1.54e-34	4.77e-37	5470	26.7	27000	22.6	1.18	DNR_DAR_3hr
201	34	MA0058.3	MAX	MA0058.3	AVCACGTGNY	MAX	4.26e-34	1.31e-36	13100	64	70900	59.3	1.08	DNR_DAR_3hr
202	34	MA1621.1	Rbpjl	MA1621.1	NNVACACCTGTBNN	Rbpjl	1.27e-32	3.91e-35	17800	87.1	1e+05	83.8	1.04	DNR_DAR_3hr
203	79	MA1107.2 (KLF9)	STREME-13	13-CCACACACA	13-CCACACACA	KLF9	4.65e-32	1.42e-34	4130	20.2	19900	16.6	1.21	DNR_DAR_3hr
204	68	MA0604.1	Atf1	MA0604.1	RTGACGTA	Atf1	8.09e-32	2.46e-34	3670	17.9	17400	14.5	1.23	DNR_DAR_3hr
205	39	MA1995.1	Npas4	MA1995.1	NNTCGTGACHN	Npas4	2.53e-31	7.67e-34	8210	40.1	42600	35.7	1.12	DNR_DAR_3hr
206	42	MA0056.2	MZF1	MA0056.2	NNAATCCCCANNN	MZF1	8.14e-31	2.45e-33	16100	78.7	89400	74.8	1.05	DNR_DAR_3hr
207	51	MA0739.1	Hic1	MA0739.1	RTGCCAACY	Hic1	1.91e-30	5.72e-33	9020	44.1	47400	39.6	1.11	DNR_DAR_3hr
208	80	MA1554.1	RFX7	MA1554.1	CGTTGCYAY	RFX7	2.67e-30	7.97e-33	11700	57.2	62900	52.6	1.09	DNR_DAR_3hr
209	37	MA1992.1	Ikzf3	MA1992.1	NNRCAGGAAGTGGVN	Ikzf3	7.47e-30	2.22e-32	16300	79.8	90900	76.1	1.05	DNR_DAR_3hr
210	37	MA0475.2	FLI1	MA0475.2	ACCGGAARTR	FLI1	1.89e-29	5.58e-32	465	2.27	1400	1.17	1.95	DNR_DAR_3hr
211	78	MA0801.1	MGA	MA0801.1	AGGTGTGA	MGA	3.27e-29	9.62e-32	17300	84.6	97100	81.2	1.04	DNR_DAR_3hr
212	81	MA1538.1	NR2F1	MA1538.1	RAGGTCANTGACCTY	NR2F1	7.51e-29	2.2e-31	5430	26.5	27200	22.8	1.17	DNR_DAR_3hr
213	40	MA0609.2	CREM	MA0609.2	NNDGTGACGTCACHNN	CREM	1.74e-28	5.07e-31	5150	25.2	25700	21.5	1.17	DNR_DAR_3hr
214	37	MA0763.1	ETV3	MA0763.1	ACCGGAAGTR	ETV3	6.22e-28	1.8e-30	403	1.97	1160	0.97	2.02	DNR_DAR_3hr
215	57	MA1574.1	THRB	MA1574.1	RRGGTCAAAGGTCAN	THRB	6.47e-28	1.87e-30	7890	38.6	41100	34.4	1.12	DNR_DAR_3hr
216	82	MA1600.1	ZNF684	MA1600.1	RYACAGTCCACCCCTTKR	ZNF684	6.73e-28	1.93e-30	6070	29.7	30800	25.8	1.15	DNR_DAR_3hr
217	41	MA1619.1	Ptf1A	MA1619.1	NNACAGCTGTNN	Ptf1A	1.05e-27	3e-30	17800	87	1e+05	84	1.04	DNR_DAR_3hr
218	56	MA1655.1	ZNF341	MA1655.1	NRGAACAGCCNN	ZNF341	1.25e-27	3.55e-30	8110	39.6	42400	35.5	1.12	DNR_DAR_3hr
219	78	MA0803.1	TBX15	MA0803.1	AGGTGTGA	TBX15	3.87e-27	1.1e-29	12200	59.4	65900	55.1	1.08	DNR_DAR_3hr
220	37	MA0686.1	SPDEF	MA0686.1	AMCCGGATGTR	SPDEF	3.88e-26	1.1e-28	6050	29.5	30800	25.8	1.15	DNR_DAR_3hr
221	41	MA0521.2	Tcf12	MA0521.2	NNACAGCTGTNN	Tcf12	2.55e-24	7.15e-27	18200	89.2	103000	86.5	1.03	DNR_DAR_3hr
222	81	MA1556.1	RXRG	MA1556.1	RRGGTCAYGACCYY	RXRG	4.96e-24	1.39e-26	5130	25	25900	21.6	1.16	DNR_DAR_3hr
223	57	MA1536.1	NR2C2	MA1536.1	RRGGTCAN	NR2C2	8.12e-24	2.26e-26	754	3.68	2810	2.35	1.57	DNR_DAR_3hr
224	57	MA1535.1	NR2C1	MA1535.1	NRRGGTCAN	NR2C1	8.4e-24	2.33e-26	9920	48.5	53100	44.5	1.09	DNR_DAR_3hr
225	83	MA1999.1	Prdm5	MA1999.1	CBGTTCTCCATCTNN	Prdm5	4.23e-23	1.17e-25	13000	63.4	71100	59.5	1.07	DNR_DAR_3hr
226	37	MA0641.1	ELF4	MA0641.1	AACCCGGAAGTR	ELF4	4.67e-23	1.28e-25	4430	21.6	22100	18.5	1.17	DNR_DAR_3hr
227	75	MA1117.1	RELB	MA1117.1	RDATTCCCCNN	RELB	2.34e-22	6.41e-25	13900	68	76800	64.3	1.06	DNR_DAR_3hr
228	84	MA0130.1	ZNF354C	MA0130.1	MTCCAC	ZNF354C	3e-22	8.16e-25	14900	72.7	82600	69.1	1.05	DNR_DAR_3hr
229	34	MA0663.1	MLX	MA0663.1	RTCACGTGAT	MLX	5.39e-22	1.46e-24	6240	30.5	32300	27	1.13	DNR_DAR_3hr
230	57	MA0065.2	Pparg::Rxra	MA0065.2	STRGGGCARAGGKCA	Pparg::Rxra	8.97e-22	2.42e-24	9870	48.2	53000	44.4	1.09	DNR_DAR_3hr
231	37	MA1484.1	ETS2	MA1484.1	DACCGGAAGY	ETS2	1.14e-21	3.06e-24	311	1.52	892	0.75	2.04	DNR_DAR_3hr
232	37	MA1708.1	ETV7	MA1708.1	DGSCGGAAGTR	ETV7	4.91e-21	1.31e-23	926	4.52	3710	3.11	1.46	DNR_DAR_3hr
233	85	MA0073.1	RREB1	MA0073.1	CCCCMAAMCAMCCMCMMMCV	RREB1	1.24e-20	3.3e-23	1520	7.44	6710	5.61	1.33	DNR_DAR_3hr
234	80	MA0799.2	RFX4	MA0799.2	BSGTTGCYWRGCAACSV	RFX4	2.95e-20	7.83e-23	1230	6.02	5250	4.4	1.37	DNR_DAR_3hr
235	34	MA0636.1	BHLHE41	MA0636.1	RTCACGTGAC	BHLHE41	3.85e-20	1.02e-22	3050	14.9	14800	12.4	1.2	DNR_DAR_3hr
236	51	MA0671.1	NFIX	MA0671.1	NNTGCCAAN	NFIX	4.66e-20	1.22e-22	18100	88.2	102000	85.7	1.03	DNR_DAR_3hr
237	44	MA1472.2	Bhlha15	MA1472.2	NVACAGCTGTBN	Bhlha15	1.11e-19	2.9e-22	15600	76.2	87200	73	1.04	DNR_DAR_3hr
238	79	MA1491.2	GLI3	MA1491.2	RGACCACCCACGWHGH	GLI3	4.85e-19	1.26e-21	1150	5.64	4910	4.11	1.37	DNR_DAR_3hr
239	44	MA1641.1	MYF5	MA1641.1	NVACAGCTGTBN	MYF5	9.62e-18	2.5e-20	14300	69.6	79300	66.4	1.05	DNR_DAR_3hr
240	57	MA0017.2	NR2F1	MA0017.2	CARAGGTCAMVNG	NR2F1	6.35e-17	1.64e-19	5680	27.7	29600	24.7	1.12	DNR_DAR_3hr
241	72	MA1602.1	ZSCAN29	MA1602.1	YGTCTACRCNGN	ZSCAN29	1.14e-16	2.93e-19	6190	30.3	32500	27.2	1.11	DNR_DAR_3hr
242	34	MA1558.1	SNAI1	MA1558.1	DRCAGGTGYD	SNAI1	9.43e-16	2.42e-18	13800	67.5	77000	64.4	1.05	DNR_DAR_3hr
243	81	MA1555.1	RXRB	MA1555.1	RRGGTCATGACCYY	RXRB	1.5e-15	3.82e-18	5430	26.5	28300	23.7	1.12	DNR_DAR_3hr
244	78	MA1565.1	TBX18	MA1565.1	DRAGGTGTGAAR	TBX18	2.12e-15	5.39e-18	17600	86	1e+05	83.7	1.03	DNR_DAR_3hr
245	41	MA1468.1	ATOH7	MA1468.1	AVCATATGBY	ATOH7	2.32e-15	5.88e-18	17900	87.5	102000	85.3	1.03	DNR_DAR_3hr
246	37	MA0645.1	ETV6	MA0645.1	MSCGGAAGTR	ETV6	4.08e-15	1.03e-17	5750	28.1	30200	25.2	1.11	DNR_DAR_3hr
247	34	MA1620.1	Ptf1A	MA1620.1	NVACACCTGTNN	Ptf1A	1.57e-14	3.95e-17	18100	88.6	103000	86.5	1.02	DNR_DAR_3hr
248	34	MA0819.2	CLOCK	MA0819.2	NRACACGTGB	CLOCK	2.23e-14	5.58e-17	4610	22.5	23800	19.9	1.13	DNR_DAR_3hr
249	58	MA0258.2	ESR2	MA0258.2	AGGTCASVNTGMCCY	ESR2	5.37e-14	1.34e-16	11200	54.9	61800	51.7	1.06	DNR_DAR_3hr
250	79	MA1107.2 (KLF9)	STREME-12	12-CACACACACAC	12-CACACACACAC	KLF9	6.4e-14	1.59e-16	855	4.18	3630	3.04	1.38	DNR_DAR_3hr
251	37	MA0760.1	ERF	MA0760.1	ACCGGAAGTR	ERF	1.06e-13	2.63e-16	432	2.11	1590	1.33	1.59	DNR_DAR_3hr
252	68	MA1969.1	THRA	MA1969.1	NYTGTGTCCTCABRTGACCTYWBB	THRA	9.95e-13	2.45e-15	4450	21.8	23100	19.4	1.12	DNR_DAR_3hr
253	51	MA1527.1	NFIC	MA1527.1	NTTGGCDNNRTGCCARN	NFIC	1.11e-12	2.73e-15	1640	8.03	7770	6.5	1.24	DNR_DAR_3hr
254	86	MA1521.1	MAFA	MA1521.1	NTGCTGASTCAGCAN	MAFA	6.65e-12	1.63e-14	10800	52.9	59800	50	1.06	DNR_DAR_3hr
255	81	MA1552.1	RARB	MA1552.1	RAGGTCATGACCTY	RARB	9.62e-12	2.34e-14	4100	20.1	21300	17.8	1.13	DNR_DAR_3hr
256	87	MA0161.2	NFIC	MA0161.2	NNCTTGGCANN	NFIC	1.03e-11	2.5e-14	14300	69.8	80200	67.1	1.04	DNR_DAR_3hr
257	78	MA1566.2	TBX3	MA1566.2	RAGGTGTGAAV	TBX3	1.93e-11	4.65e-14	15200	74.2	85600	71.6	1.04	DNR_DAR_3hr
258	68	MA0638.1	CREB3	MA0638.1	VTGCCACGTCAYCR	CREB3	2.36e-11	5.68e-14	4520	22.1	23700	19.8	1.12	DNR_DAR_3hr
259	34	MA1559.1	SNAI3	MA1559.1	RRCAGGTGYA	SNAI3	7.12e-11	1.71e-13	10500	51.5	58300	48.7	1.06	DNR_DAR_3hr
260	40	MA0862.1	GMEB2	MA0862.1	TTACGTAA	GMEB2	8.3e-11	1.98e-13	4380	21.4	22900	19.2	1.12	DNR_DAR_3hr
261	88	MA1651.1	ZFP42	MA1651.1	NNNHCAARATGGCTGCCNBNN	ZFP42	9.77e-11	2.32e-13	290	1.42	1020	0.85	1.67	DNR_DAR_3hr
262	68	MA0844.1	XBP1	MA0844.1	WDKGMCACGTCATC	XBP1	1.59e-10	3.76e-13	909	4.44	4050	3.39	1.31	DNR_DAR_3hr
263	78	MA0806.1	TBX4	MA0806.1	AGGTGTGA	TBX4	4.59e-10	1.08e-12	20100	98	116000	97.2	1.01	DNR_DAR_3hr
264	37	MA1931.1	ELK1::HOXA1	MA1931.1	ACCGGAAGTAATTA	ELK1::HOXA1	2.41e-09	5.67e-12	510	2.49	2100	1.76	1.42	DNR_DAR_3hr
265	79	15-CACACACCACACA	STREME-15	15-CACACACCACACA	15-CACACACCACACA	CACACACCACACA	3.04e-09	7.12e-12	1330	6.48	6310	5.28	1.23	DNR_DAR_3hr
266	87	MA0502.2	NFYB	MA0502.2	CYCATTGGCCVV	NFYB	3.8e-09	8.87e-12	13300	65.1	74800	62.6	1.04	DNR_DAR_3hr
267	68	MA0839.1	CREB3L1	MA0839.1	VTGCCACGTCAYCA	CREB3L1	1.98e-08	4.59e-11	777	3.8	3480	2.91	1.3	DNR_DAR_3hr
268	41	MA0668.2	Neurod2	MA0668.2	NNGRACAGATGGYNN	Neurod2	3.13e-08	7.24e-11	17400	84.9	99300	83	1.02	DNR_DAR_3hr
269	34	MA0825.1	MNT	MA0825.1	RVCACGTGMH	MNT	6.16e-08	1.42e-10	5790	28.3	31200	26.1	1.08	DNR_DAR_3hr
270	68	MA1466.1	ATF6	MA1466.1	TGRTGACGTGGCAN	ATF6	2.75e-07	6.32e-10	642	3.14	2850	2.38	1.32	DNR_DAR_3hr
271	37	MA0098.3	ETS1	MA0098.3	ACCGGAARTR	ETS1	3.75e-07	8.59e-10	14600	71.3	82700	69.1	1.03	DNR_DAR_3hr
272	89	MA1542.1	OSR1	MA1542.1	HGCTACYGTD	OSR1	1.35e-06	3.08e-09	15900	77.6	90500	75.7	1.03	DNR_DAR_3hr
273	51	MA0119.1	NFIC::TLX1	MA0119.1	TGGCASSRWGCCAA	NFIC::TLX1	2.34e-06	5.33e-09	1360	6.64	6680	5.59	1.19	DNR_DAR_3hr
274	75	MA0101.1	REL	MA0101.1	BGGRNWTTCC	REL	2.57e-06	5.81e-09	1470	7.16	7260	6.08	1.18	DNR_DAR_3hr
275	90	MA1114.1	PBX3	MA1114.1	NNNTGAGTGACAGGBNN	PBX3	4.28e-06	9.67e-09	18800	91.9	108000	90.6	1.01	DNR_DAR_3hr
276	34	MA0820.1	FIGLA	MA0820.1	WMCACCTGKW	FIGLA	4.97e-06	1.12e-08	19500	95	112000	94.1	1.01	DNR_DAR_3hr
277	44	MA1646.1	OSR2	MA1646.1	NNACAGAAGCNN	OSR2	5.42e-06	1.21e-08	15800	77	89900	75.2	1.02	DNR_DAR_3hr
278	78	MA0805.1	TBX1	MA0805.1	AGGTGTGA	TBX1	6.08e-06	1.36e-08	15300	74.8	87200	72.9	1.03	DNR_DAR_3hr
279	56	MA1725.1	ZNF189	MA1725.1	NNTGCTGTTCCHB	ZNF189	1.07e-05	2.39e-08	14900	72.8	84700	70.9	1.03	DNR_DAR_3hr
280	41	MA1638.1	HAND2	MA1638.1	NVCAGATGNN	HAND2	1.15e-05	2.56e-08	6820	33.3	37500	31.4	1.06	DNR_DAR_3hr
281	78	MA1571.1	TGIF2LX	MA1571.1	TGACAGCTGTCA	TGIF2LX	1.57e-05	3.47e-08	14400	70.2	81600	68.2	1.03	DNR_DAR_3hr
282	34	MA0059.1	MAX::MYC	MA0059.1	RASCACGTGGT	MAX::MYC	3.55e-05	7.81e-08	1020	4.96	4930	4.12	1.2	DNR_DAR_3hr
283	34	MA0622.1	Mlxip	MA0622.1	BCACGTGK	Mlxip	5.29e-05	1.16e-07	791	3.87	3750	3.14	1.23	DNR_DAR_3hr
284	57	MA1537.1	NR2F1	MA1537.1	RRGGTCAAAGGTCAN	NR2F1	0.000251	5.49e-07	3110	15.2	16600	13.9	1.1	DNR_DAR_3hr
285	78	MA1572.1	TGIF2LY	MA1572.1	TGACAGCTGTCA	TGIF2LY	0.000286	6.23e-07	14000	68.2	79400	66.4	1.03	DNR_DAR_3hr
286	37	MA0473.3	ELF1	MA0473.3	RDVCAGGAAGTGVN	ELF1	0.000463	1e-06	17300	84.7	99600	83.3	1.02	DNR_DAR_3hr
287	91	MA1531.1	NR1D1	MA1531.1	RGGTYAGTRGGTCAN	NR1D1	0.000556	1.2e-06	2700	13.2	14300	12	1.1	DNR_DAR_3hr
288	88	MA0095.3	Yy1	MA0095.3	NNCAAAATGGCN	Yy1	0.000758	1.63e-06	32	0.16	59	0.05	3.21	DNR_DAR_3hr
289	37	MA1957.1	HOXB2::ELK1	MA1957.1	RCCGGAAGTMRTTA	HOXB2::ELK1	0.00155	3.33e-06	447	2.18	2040	1.71	1.28	DNR_DAR_3hr
290	2	MA0657.1	KLF13	MA0657.1	RTGMCACGCCCCTTTTTG	KLF13	0.00226	4.84e-06	260	1.27	1100	0.92	1.39	DNR_DAR_3hr
291	80	MA0510.2	RFX5	MA0510.2	SGTTGCCATGGYAACV	RFX5	0.0027	5.75e-06	42	0.21	99	0.08	2.51	DNR_DAR_3hr
292	41	MA1109.1	NEUROD1	MA1109.1	NRACAGATGGYNN	NEUROD1	0.0043	9.15e-06	18700	91.3	108000	90.3	1.01	DNR_DAR_3hr
293	75	MA0107.1	RELA	MA0107.1	GGGRATTTCC	RELA	0.00736	1.56e-05	4520	22.1	24800	20.8	1.06	DNR_DAR_3hr
294	11	MA1116.1	RBPJ	MA1116.1	BVTGGGAANN	RBPJ	0.0101	2.12e-05	403	1.97	1860	1.55	1.27	DNR_DAR_3hr
295	34	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	0.0101	2.13e-05	362	1.77	1640	1.38	1.29	DNR_DAR_3hr
296	78	MA1567.2	Tbx6	MA1567.2	NRGGTGTGAANN	Tbx6	0.0107	2.25e-05	20200	98.5	117000	98	1	DNR_DAR_3hr
297	80	MA0798.3	RFX3	MA0798.3	CGTTRCCATGGCAACS	RFX3	0.0143	2.99e-05	34	0.17	78	0.07	2.59	DNR_DAR_3hr
298	81	MA1553.1	RARG	MA1553.1	RAGGTCATGACCTY	RARG	0.0172	3.58e-05	3330	16.3	18100	15.2	1.07	DNR_DAR_3hr
299	80	MA0509.3	RFX1	MA0509.3	SGTTGCCATGGCAACS	RFX1	0.0245	5.09e-05	42	0.21	111	0.09	2.24	DNR_DAR_3hr
300	37	MA1935.1	ERF::FOXI1	MA1935.1	RTAAACMGGAARTR	ERF::FOXI1	0.0262	5.42e-05	65	0.32	206	0.17	1.86	DNR_DAR_3hr
301	34	MA0526.4	USF2	MA0526.4	DRTCACGTGAYH	USF2	0.0297	6.13e-05	111	0.54	414	0.35	1.58	DNR_DAR_3hr
302	81	MA1146.1	NR1H4::RXRA	MA1146.1	GAGKTCATTGACCYB	NR1H4::RXRA	0.0331	6.81e-05	577	2.82	2810	2.35	1.2	DNR_DAR_3hr
303	75	MA0105.4	NFKB1	MA0105.4	AGGGGAWTCCCCT	NFKB1	0.0399	8.17e-05	255	1.25	1130	0.94	1.33	DNR_DAR_3hr
304	34	MA0831.3	TFE3	MA0831.3	GTCACGTGAC	TFE3	0.0459	9.37e-05	48	0.23	139	0.12	2.04	DNR_DAR_3hr
305	92	MA1573.2	Thap11	MA1573.2	ACTACAABTCCCAG	Thap11	0.0466	9.49e-05	6880	33.6	38500	32.2	1.04	DNR_DAR_3hr
306	37	MA0762.1	ETV2	MA0762.1	AACCGGAAATR	ETV2	0.0471	9.56e-05	34	0.17	84	0.07	2.41	DNR_DAR_3hr

ER_rat <- 1.25
# mrc_type <- "EAR_open"
DNR_DAR_3hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  # geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_col(aes(x=log10Evalue))+
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DNR_DAR_3hr_combo response peaks(200bp) Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DNR_DAR_3hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  # geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*.5), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.5,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DNR DAR 3 hour response peaks(200bp) Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DNR_DAR_24hr data

DNR_DAR_24hr_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_24_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DNR_DAR_24hr_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_24_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DNR_DAR_24hr_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_24_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DNR_DAR_24hr_sea_all <- rbind(DNR_DAR_24hr_sea_disc, DNR_DAR_24hr_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DNR_DAR_24hr_combo <- DNR_DAR_24hr_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DNR_DAR_24hr_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="DNR_DAR_24hr")

DNR_DAR_24hr_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp DNR_DAR_24hr") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp DNR_DAR_24hr
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA0477.2 (FOSL1)	STREME-1	1-NRATGASTCATYN	NRATGASTCATYN	FOSL1	0	0	9200	12.8	4200	6.17	2.07	DNR_DAR_24hr
2	1	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	0	0	8840	12.3	3960	5.82	2.11	DNR_DAR_24hr
3	1	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	0	0	8670	12	3920	5.77	2.09	DNR_DAR_24hr
4	1	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	0	0	7810	10.8	3360	4.94	2.19	DNR_DAR_24hr
5	1	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	0	0	8350	11.6	3720	5.47	2.12	DNR_DAR_24hr
6	1	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	0	0	9410	13.1	4460	6.56	1.99	DNR_DAR_24hr
7	1	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	0	0	8800	12.2	4050	5.96	2.05	DNR_DAR_24hr
8	1	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	0	0	9570	13.3	4590	6.75	1.97	DNR_DAR_24hr
9	1	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	0	0	10900	15.1	5510	8.1	1.86	DNR_DAR_24hr
10	1	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	0	0	7620	10.6	3270	4.81	2.2	DNR_DAR_24hr
11	1	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	0	0	8970	12.4	4210	6.19	2.01	DNR_DAR_24hr
12	1	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	0	0	6790	9.44	2760	4.06	2.33	DNR_DAR_24hr
13	1	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	0	0	9160	12.7	4360	6.42	1.98	DNR_DAR_24hr
14	1	MA0655.1 (JDP2)	STREME-2	2-ATGAATCA	ATGAATCA	JDP2	0	0	10400	14.5	5280	7.77	1.86	DNR_DAR_24hr
15	1	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	0	0	11700	16.3	6280	9.24	1.76	DNR_DAR_24hr
16	1	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	0	0	8130	11.3	3750	5.51	2.05	DNR_DAR_24hr
17	1	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	1.28457067918724e-322	1.28457067918724e-322	6960	9.66	3010	4.43	2.18	DNR_DAR_24hr
18	1	MA0476.1 (FOS)	MEME-2	ATGAGTCA	ATGAGTCA	FOS	1.90000000007959e-314	6.62000001534372e-316	11100	15.4	5970	8.78	1.75	DNR_DAR_24hr
19	1	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	1.66000000000002e-310	5.47000000000005e-312	7610	10.6	3510	5.16	2.05	DNR_DAR_24hr
20	1	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	4.16999999999997e-310	1.31000000000011e-311	9380	13	4760	6.99	1.86	DNR_DAR_24hr
21	1	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	6.17000000000002e-310	1.84000000000024e-311	11100	15.5	6040	8.89	1.74	DNR_DAR_24hr
22	1	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	1.37e-309	3.89999999999994e-311	9980	13.9	5200	7.64	1.81	DNR_DAR_24hr
23	1	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	3.63e-301	9.9e-303	10400	14.5	5560	8.18	1.77	DNR_DAR_24hr
24	1	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	5.49e-297	1.43e-298	7920	11	3790	5.58	1.97	DNR_DAR_24hr
25	1	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	4.28e-296	1.07e-297	4550	6.32	1600	2.36	2.68	DNR_DAR_24hr
26	1	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	2.82e-292	6.81e-294	11000	15.3	6090	8.95	1.71	DNR_DAR_24hr
27	1	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	6.82e-277	1.58e-278	10500	14.6	5800	8.53	1.71	DNR_DAR_24hr
28	1	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	4.8e-275	1.08e-276	12900	17.9	7600	11.2	1.6	DNR_DAR_24hr
29	1	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	3.7e-218	8.02e-220	14100	19.6	9050	13.3	1.47	DNR_DAR_24hr
30	1	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	5.72e-124	1.2e-125	15600	21.6	11300	16.6	1.3	DNR_DAR_24hr
31	1	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	5.36e-116	1.09e-117	18700	26	14100	20.7	1.25	DNR_DAR_24hr
32	1	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	1.23e-99	2.4e-101	12500	17.3	8980	13.2	1.31	DNR_DAR_24hr
33	1	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	8.94e-74	1.7e-75	7040	9.78	4790	7.04	1.39	DNR_DAR_24hr
34	2	MA1990.1 (Gli1)	STREME-3	3-ACACACCACACACAC	ACACACCACACACAC	Gli1	2.1e-71	3.87e-73	468	0.65	61	0.09	7.15	DNR_DAR_24hr
35	2	6-ACACACACACCACAC	STREME-6	6-ACACACACACCACAC	ACACACACACCACAC	ACACACACACCACAC	3.04e-64	5.46e-66	494	0.69	84	0.12	5.5	DNR_DAR_24hr
36	1	MA0150.2	Nfe2l2	MA0150.2	CASNATGACTCAGCA	Nfe2l2	1.48e-53	2.59e-55	25200	35	21100	31.1	1.13	DNR_DAR_24hr
37	3	9-ACACATRCACAC	STREME-9	9-ACACATRCACAC	ACACATRCACAC	ACACATRCACAC	1.34e-43	2.27e-45	714	0.99	253	0.37	2.66	DNR_DAR_24hr
38	3	MA0522.3 (TCF3)	STREME-10	10-ACACACATGCACD	10-ACACACATGCACD	TCF3	2.82e-41	4.65e-43	706	0.98	257	0.38	2.59	DNR_DAR_24hr
39	2	MA0073.1 (RREB1)	STREME-7	7-CACACACCACACC	CACACACCACACC	RREB1	5.63e-39	9.06e-41	666	0.93	242	0.36	2.59	DNR_DAR_24hr
40	2	MA1107.2 (KLF9)	STREME-11	11-CACACACACATAM	11-CACACACACATAM	KLF9	3.52e-35	5.52e-37	2940	4.08	1920	2.83	1.44	DNR_DAR_24hr
41	4	MA0766.2 (GATA5)	STREME-13	13-CWGATA	13-CWGATA	GATA5	1.61e-34	2.46e-36	48500	67.4	43600	64.1	1.05	DNR_DAR_24hr
42	1	MA0591.1	Bach1::Mafk	MA0591.1	RSSATGACTCAGCAB	Bach1::Mafk	1.02e-31	1.52e-33	3910	5.43	2750	4.04	1.34	DNR_DAR_24hr
43	3	ACACACACACACACA	MEME-5	ACACACACACACACA	ACACACACACACACA	ACACACACACACACA	3.75e-30	5.47e-32	1900	2.64	1170	1.71	1.54	DNR_DAR_24hr
44	5	MA0904.2	HOXB5	MA0904.2	STAATTAS	HOXB5	4.38e-27	6.25e-29	40400	56.1	36100	53.1	1.06	DNR_DAR_24hr
45	1	MA1639.1	MEIS1	MA1639.1	NHCATMAATCAHN	MEIS1	2.66e-26	3.7e-28	28200	39.2	24700	36.3	1.08	DNR_DAR_24hr
46	5	MA0158.2	HOXA5	MA0158.2	GYMATTAS	HOXA5	6.67e-24	9.1e-26	31000	43	27300	40.2	1.07	DNR_DAR_24hr
47	5	MA1495.1	HOXA1	MA1495.1	STAATTAS	HOXA1	1.73e-23	2.31e-25	33200	46.1	29400	43.2	1.07	DNR_DAR_24hr
48	6	MA0106.3 (TP53)	STREME-4	4-CATGTCCA	CATGTCCA	TP53	6.8e-23	8.89e-25	5880	8.17	4560	6.7	1.22	DNR_DAR_24hr
49	7	MA0106.3	TP53	MA0106.3	RACATGYCCGGRCATGTY	TP53	9.99e-23	1.28e-24	1180	1.64	686	1.01	1.63	DNR_DAR_24hr
50	5	MA0902.2	HOXB2	MA0902.2	SYAATTAS	HOXB2	1.26e-22	1.58e-24	45300	63	41000	60.2	1.04	DNR_DAR_24hr
51	5	MA0707.2	MNX1	MA0707.2	VYRATTAK	MNX1	1.81e-22	2.22e-24	37100	51.5	33200	48.8	1.06	DNR_DAR_24hr
52	5	MA0705.1	Lhx8	MA0705.1	CTAATTAV	Lhx8	1.83e-20	2.21e-22	42000	58.3	37900	55.7	1.05	DNR_DAR_24hr
53	8	MA1155.1	ZSCAN4	MA1155.1	TGCACACACTGAAAA	ZSCAN4	2.81e-20	3.33e-22	1600	2.23	1030	1.51	1.47	DNR_DAR_24hr
54	5	MA0886.1	EMX2	MA0886.1	VBTAATTARB	EMX2	1.09e-19	1.27e-21	49700	69.1	45300	66.6	1.04	DNR_DAR_24hr
55	9	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	6.17e-19	7.04e-21	27400	38	24200	35.6	1.07	DNR_DAR_24hr
56	5	MA1519.1	LHX5	MA1519.1	STAATTAV	LHX5	1.06e-16	1.18e-18	30800	42.8	27500	40.5	1.06	DNR_DAR_24hr
57	5	MA1502.1	HOXB8	MA1502.1	GYMATTAM	HOXB8	5.96e-16	6.56e-18	43100	59.9	39100	57.6	1.04	DNR_DAR_24hr
58	10	MA0774.1 (MEIS2)	STREME-5	5-CTGTCARCAS	CTGTCARCAS	MEIS2	7.4e-16	8.01e-18	1780	2.48	1220	1.8	1.38	DNR_DAR_24hr
59	9	MA1108.2	MXI1	MA1108.2	NNCACATGBN	MXI1	1.33e-15	1.41e-17	8460	11.8	7000	10.3	1.14	DNR_DAR_24hr
60	5	MA0710.1	NOTO	MA0710.1	NYTAATTAVN	NOTO	1.49e-15	1.56e-17	57000	79.2	52500	77.3	1.02	DNR_DAR_24hr
61	11	MA1143.1	FOSL1::JUND	MA1143.1	RTGACGTMAY	FOSL1::JUND	4.86e-15	5e-17	32100	44.6	28800	42.3	1.05	DNR_DAR_24hr
62	1	MA1113.2	PBX2	MA1113.2	NHCATAAATCAHN	PBX2	6.85e-15	6.93e-17	39700	55.1	35900	52.8	1.04	DNR_DAR_24hr
63	5	MA0701.2	LHX9	MA0701.2	CYAATTAR	LHX9	3.96e-14	3.94e-16	27900	38.8	24900	36.6	1.06	DNR_DAR_24hr
64	12	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	2.28e-13	2.24e-15	63800	88.6	59300	87.2	1.02	DNR_DAR_24hr
65	13	MA0093.3	USF1	MA0093.3	NDGTCATGTGACHN	USF1	4.65e-13	4.49e-15	53800	74.7	49500	72.8	1.03	DNR_DAR_24hr
66	7	MA0861.1	TP73	MA0861.1	DRCATGTCNNRACAYGYM	TP73	1.17e-12	1.12e-14	15400	21.4	13400	19.7	1.09	DNR_DAR_24hr
67	12	MA1103.2	FOXK2	MA1103.2	DDGTAAACANN	FOXK2	9.72e-12	9.1e-14	67100	93.2	62600	92.1	1.01	DNR_DAR_24hr
68	14	MA0596.1	SREBF2	MA0596.1	RTGGGGTGAY	SREBF2	1.12e-11	1.04e-13	17400	24.2	15300	22.4	1.08	DNR_DAR_24hr
69	5	MA0612.2	EMX1	MA0612.2	BTAATTAS	EMX1	1.19e-11	1.08e-13	31000	43	27900	41	1.05	DNR_DAR_24hr
70	12	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	1.29e-11	1.15e-13	61100	84.8	56700	83.3	1.02	DNR_DAR_24hr
71	15	MA0786.1	POU3F1	MA0786.1	WTATGCWAATKW	POU3F1	2.05e-11	1.81e-13	59400	82.6	55100	81	1.02	DNR_DAR_24hr
72	12	MA0148.4	FOXA1	MA0148.4	WWGTAAACATNN	FOXA1	2.15e-11	1.87e-13	60900	84.6	56500	83.1	1.02	DNR_DAR_24hr
73	16	MA0676.1	Nr2e1	MA0676.1	AAAAGTCAA	Nr2e1	3.29e-11	2.83e-13	30200	42	27200	40	1.05	DNR_DAR_24hr
74	5	MA0912.2	HOXD3	MA0912.2	CTAATTAC	HOXD3	6.01e-11	5.1e-13	21100	29.3	18700	27.5	1.06	DNR_DAR_24hr
75	10	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	7.52e-11	6.3e-13	60800	84.5	56500	83	1.02	DNR_DAR_24hr
76	12	MA0047.3	FOXA2	MA0047.3	RWGTAAACANN	FOXA2	8.42e-11	6.95e-13	66100	91.7	61600	90.6	1.01	DNR_DAR_24hr
77	10	MA0117.2	Mafb	MA0117.2	AWWNTGCTGACD	Mafb	1.18e-10	9.59e-13	11700	16.3	10100	14.8	1.1	DNR_DAR_24hr
78	7	MA0525.2	TP63	MA0525.2	RACATGTYGKGACATGTC	TP63	1.96e-10	1.57e-12	681	0.95	412	0.61	1.56	DNR_DAR_24hr
79	17	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	2.06e-10	1.63e-12	50800	70.6	46800	68.8	1.03	DNR_DAR_24hr
80	9	MA1570.1	TFAP4	MA1570.1	AHCATRTGDT	TFAP4	2.44e-10	1.91e-12	23300	32.3	20800	30.5	1.06	DNR_DAR_24hr
81	1	MA1640.1	MEIS2	MA1640.1	NNATGATTTATGDNH	MEIS2	2.68e-10	2.06e-12	58000	80.6	53800	79.1	1.02	DNR_DAR_24hr
82	15	MA1115.1	POU5F1	MA1115.1	WHATGCAAATN	POU5F1	2.7e-10	2.06e-12	58700	81.5	54400	80	1.02	DNR_DAR_24hr
83	5	MA0644.2	ESX1	MA0644.2	YYAATTAN	ESX1	3.04e-10	2.3e-12	55600	77.3	51400	75.6	1.02	DNR_DAR_24hr
84	12	MA0032.2	FOXC1	MA0032.2	WAWGTAAAYAW	FOXC1	3.36e-10	2.51e-12	58100	80.7	53800	79.2	1.02	DNR_DAR_24hr
85	18	MA0122.3	Nkx3-2	MA0122.3	WWAAMCACTTAAN	Nkx3-2	6.93e-10	5.12e-12	57400	79.8	53200	78.2	1.02	DNR_DAR_24hr
86	15	MA0792.1	POU5F1B	MA0792.1	TATGCWAAT	POU5F1B	1.09e-09	7.95e-12	63300	87.9	58900	86.6	1.01	DNR_DAR_24hr
87	12	MA0042.2	FOXI1	MA0042.2	GTAAACA	FOXI1	1.41e-09	1.02e-11	54900	76.3	50800	74.7	1.02	DNR_DAR_24hr
88	12	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	1.76e-09	1.26e-11	64300	89.4	60000	88.2	1.01	DNR_DAR_24hr
89	12	MA0481.3	FOXP1	MA0481.3	NDGTAAACANH	FOXP1	2.7e-09	1.9e-11	67700	94	63300	93.1	1.01	DNR_DAR_24hr
90	12	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	4.07e-09	2.84e-11	60900	84.6	56600	83.2	1.02	DNR_DAR_24hr
91	5	MA0675.1	NKX6-2	MA0675.1	NYMATTAA	NKX6-2	5.32e-09	3.67e-11	64200	89.2	59900	88	1.01	DNR_DAR_24hr
92	5	MA0027.2	EN1	MA0027.2	SYAATTAV	EN1	9.72e-09	6.63e-11	47100	65.4	43300	63.7	1.03	DNR_DAR_24hr
93	9	MA0620.3	MITF	MA0620.3	NNNDRTCACGTGAYHNNN	MITF	1.41e-08	9.5e-11	41500	57.6	38000	55.9	1.03	DNR_DAR_24hr
94	19	MA1479.1	DMRTC2	MA1479.1	AATTGMTACATT	DMRTC2	2.06e-08	1.37e-10	53800	74.7	49700	73.1	1.02	DNR_DAR_24hr
95	5	MA0708.2	MSX2	MA0708.2	SCAATTAV	MSX2	3.01e-08	1.99e-10	58400	81.1	54200	79.7	1.02	DNR_DAR_24hr
96	4	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	3.24e-08	2.12e-10	21100	29.2	18800	27.7	1.06	DNR_DAR_24hr
97	20	MA0502.2	NFYB	MA0502.2	CYCATTGGCCVV	NFYB	4.07e-08	2.64e-10	4560	6.34	3750	5.52	1.15	DNR_DAR_24hr
98	21	MA0036.3	GATA2	MA0036.3	NBCTTATCTNH	GATA2	4.44e-08	2.84e-10	6630	9.2	5600	8.23	1.12	DNR_DAR_24hr
99	5	MA0910.2	HOXD8	MA0910.2	GYMATTAM	HOXD8	5.92e-08	3.75e-10	26800	37.2	24200	35.6	1.05	DNR_DAR_24hr
100	5	MA0879.2	DLX1	MA0879.2	VYAATTAN	DLX1	6.89e-08	4.33e-10	67400	93.6	63100	92.7	1.01	DNR_DAR_24hr
101	5	MA0718.1	RAX	MA0718.1	RYYAATTARH	RAX	7.03e-08	4.37e-10	61400	85.3	57200	84.1	1.01	DNR_DAR_24hr
102	15	MA0142.1	Pou5f1::Sox2	MA0142.1	CWTTGTYATGCAAAT	Pou5f1::Sox2	8.32e-08	5.12e-10	55700	77.3	51600	75.9	1.02	DNR_DAR_24hr
103	4	MA0140.2	GATA1::TAL1	MA0140.2	MTTATCWSNNNNNHVCAG	GATA1::TAL1	2.79e-07	1.7e-09	23100	32.1	20800	30.6	1.05	DNR_DAR_24hr
104	5	MA1505.1	HOXC8	MA1505.1	KTAATTAM	HOXC8	3.17e-07	1.91e-09	64600	89.7	60300	88.7	1.01	DNR_DAR_24hr
105	15	MA0785.1	POU2F1	MA0785.1	AWTATGCWAATK	POU2F1	3.74e-07	2.24e-09	57900	80.4	53800	79	1.02	DNR_DAR_24hr
106	12	MA1607.1	Foxl2	MA1607.1	DDWATGTAAACANN	Foxl2	4.46e-07	2.64e-09	63600	88.4	59400	87.3	1.01	DNR_DAR_24hr
107	5	MA1530.1	NKX6-3	MA1530.1	VYCATTAWW	NKX6-3	5.51e-07	3.23e-09	13900	19.3	12300	18	1.07	DNR_DAR_24hr
108	5	MA0630.1	SHOX	MA0630.1	HTAATTRR	SHOX	6.08e-07	3.53e-09	62700	87	58400	85.9	1.01	DNR_DAR_24hr
109	23	MA0611.2	Dux	MA0611.2	NTGATTBAATCAVWNN	Dux	7.5e-07	4.32e-09	11700	16.2	10200	15	1.08	DNR_DAR_24hr
110	17	MA0063.2	NKX2-5	MA0063.2	NNCACTCAANN	NKX2-5	8.7e-07	4.96e-09	49000	68.1	45300	66.6	1.02	DNR_DAR_24hr
111	12	MA0849.1	FOXO6	MA0849.1	GTAAACA	FOXO6	9.85e-07	5.57e-09	23700	32.9	21300	31.4	1.05	DNR_DAR_24hr
112	12	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	1.04e-06	5.81e-09	37800	52.6	34700	51	1.03	DNR_DAR_24hr
113	10	MA0774.1	MEIS2	MA0774.1	TTGACAGS	MEIS2	1.11e-06	6.14e-09	29300	40.7	26600	39.1	1.04	DNR_DAR_24hr
114	21	MA0037.4	Gata3	MA0037.4	NHTCTTATCTNH	Gata3	1.23e-06	6.78e-09	8510	11.8	7360	10.8	1.09	DNR_DAR_24hr
115	5	MA0704.1	Lhx4	MA0704.1	YTAATTAR	Lhx4	1.47e-06	8.02e-09	60800	84.5	56700	83.4	1.01	DNR_DAR_24hr
116	1	MA1645.1	NKX2-2	MA1645.1	NNNCCACTCAANNN	NKX2-2	2.02e-06	1.1e-08	56700	78.8	52700	77.5	1.02	DNR_DAR_24hr
117	12	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	2.09e-06	1.12e-08	49200	68.3	45400	66.8	1.02	DNR_DAR_24hr
118	22	MA0084.1	SRY	MA0084.1	NWWAACAAT	SRY	2.23e-06	1.19e-08	65900	91.5	61600	90.6	1.01	DNR_DAR_24hr
119	12	MA0480.2	Foxo1	MA0480.2	NDGTAAACANN	Foxo1	2.28e-06	1.2e-08	67100	93.2	62800	92.3	1.01	DNR_DAR_24hr
120	17	MA1523.1	MSANTD3	MA1523.1	STVCACTCAC	MSANTD3	2.39e-06	1.25e-08	61000	84.7	56800	83.6	1.01	DNR_DAR_24hr
121	5	MA0720.1	Shox2	MA0720.1	YYAATTAR	Shox2	3.05e-06	1.58e-08	46000	63.9	42400	62.4	1.02	DNR_DAR_24hr
122	9	MA0672.1	NKX2-3	MA0672.1	VCCACTTRAV	NKX2-3	3.57e-06	1.84e-08	7920	11	6840	10	1.09	DNR_DAR_24hr
123	20	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	3.62e-06	1.85e-08	53200	73.9	49400	72.6	1.02	DNR_DAR_24hr
124	23	MA1720.1 (ZNF85)	STREME-8	8-TGATGAAATCTCAT	TGATGAAATCTCAT	ZNF85	5.09e-06	2.58e-08	232	0.32	116	0.17	1.88	DNR_DAR_24hr
125	18	MA1978.1	ZNF354A	MA1978.1	HWAADWATAAATGRAYWAWTT	ZNF354A	5.85e-06	2.94e-08	60200	83.6	56100	82.5	1.01	DNR_DAR_24hr
126	15	MA0789.1	POU3F4	MA0789.1	TATGCWAAT	POU3F4	7.36e-06	3.67e-08	47400	65.8	43800	64.4	1.02	DNR_DAR_24hr
127	5	MA0654.1	ISX	MA0654.1	YYAATTAR	ISX	8.5e-06	4.2e-08	43800	60.8	40400	59.3	1.02	DNR_DAR_24hr
128	24	MA1573.2	Thap11	MA1573.2	ACTACAABTCCCAG	Thap11	9.57e-06	4.69e-08	251	0.35	131	0.19	1.8	DNR_DAR_24hr
129	25	12-CCMATKGG	STREME-12	12-CCMATKGG	12-CCMATKGG	CCMATKGG	9.78e-06	4.76e-08	510	0.71	325	0.48	1.48	DNR_DAR_24hr
130	21	MA1970.1	TRPS1	MA1970.1	NHTCTTATCTNH	TRPS1	1.22e-05	5.88e-08	14000	19.5	12500	18.3	1.06	DNR_DAR_24hr
131	14	MA0595.1	SREBF1	MA0595.1	VTCACCCCAY	SREBF1	1.47e-05	7.02e-08	13700	19	12200	17.9	1.06	DNR_DAR_24hr
132	26	MA0650.3	Hoxa13	MA0650.3	NNCCAATAAAAN	Hoxa13	1.49e-05	7.09e-08	63500	88.2	59300	87.2	1.01	DNR_DAR_24hr
133	12	MA0157.3	Foxo3	MA0157.3	NDGTAAACARNN	Foxo3	1.57e-05	7.37e-08	68000	94.4	63800	93.8	1.01	DNR_DAR_24hr
134	10	MA0842.2	NRL	MA0842.2	AAWWNTGCTGACG	NRL	1.57e-05	7.37e-08	10600	14.8	9350	13.8	1.07	DNR_DAR_24hr
135	27	MA0803.1	TBX15	MA0803.1	AGGTGTGA	TBX15	2.09e-05	9.72e-08	32600	45.3	29800	43.8	1.03	DNR_DAR_24hr
136	27	MA0689.1	TBX20	MA0689.1	WAGGTGTGAAR	TBX20	2.2e-05	1.02e-07	44800	62.2	41400	60.8	1.02	DNR_DAR_24hr
137	5	MA1960.1	MGA::EVX1	MA1960.1	RGGTGWTAATKD	MGA::EVX1	2.51e-05	1.15e-07	53300	74.1	49500	72.8	1.02	DNR_DAR_24hr
138	17	MA1114.1	PBX3	MA1114.1	NNNTGAGTGACAGGBNN	PBX3	2.59e-05	1.18e-07	29900	41.6	27300	40.1	1.04	DNR_DAR_24hr
139	15	MA0627.2	POU2F3	MA0627.2	NWTATGCAAATNH	POU2F3	2.6e-05	1.18e-07	52000	72.3	48300	71	1.02	DNR_DAR_24hr
140	12	MA0614.1	Foxj2	MA0614.1	RTAAACAA	Foxj2	4.31e-05	1.93e-07	39500	54.9	36400	53.5	1.03	DNR_DAR_24hr
141	17	MA1124.1	ZNF24	MA1124.1	CATTCATTCATTC	ZNF24	4.53e-05	2.01e-07	5130	7.13	4360	6.41	1.11	DNR_DAR_24hr
142	5	MA1481.1	DRGX	MA1481.1	YYAATTAN	DRGX	5.65e-05	2.5e-07	40900	56.9	37700	55.5	1.03	DNR_DAR_24hr
143	5	MA0709.1	Msx3	MA0709.1	SCAATTAN	Msx3	5.85e-05	2.57e-07	42300	58.7	39000	57.3	1.02	DNR_DAR_24hr
144	21	MA0482.2	GATA4	MA0482.2	NNCCTTATCTNH	GATA4	5.92e-05	2.58e-07	3950	5.48	3300	4.86	1.13	DNR_DAR_24hr
145	28	MA0073.1	RREB1	MA0073.1	CCCCMAAMCAMCCMCMMMCV	RREB1	6.42e-05	2.78e-07	439	0.61	278	0.41	1.49	DNR_DAR_24hr
146	5	MA0661.1	MEOX1	MA0661.1	VSTAATTAHC	MEOX1	7.88e-05	3.39e-07	62600	87	58500	86.1	1.01	DNR_DAR_24hr
147	9	MA0831.3	TFE3	MA0831.3	GTCACGTGAC	TFE3	8.54e-05	3.65e-07	8260	11.5	7200	10.6	1.08	DNR_DAR_24hr
148	29	MA0698.1	ZBTB18	MA0698.1	NATCCAGATGTKB	ZBTB18	0.000108	4.57e-07	25500	35.4	23200	34.1	1.04	DNR_DAR_24hr
149	18	MA0914.1	ISL2	MA0914.1	GCAMTTAR	ISL2	0.000135	5.69e-07	66600	92.6	62500	91.8	1.01	DNR_DAR_24hr
150	30	MA0090.3	TEAD1	MA0090.3	NNACATTCCAGSN	TEAD1	0.000148	6.19e-07	58200	80.8	54200	79.7	1.01	DNR_DAR_24hr
151	12	MA0031.1	FOXD1	MA0031.1	GTAAACAW	FOXD1	0.000152	6.3e-07	49800	69.2	46200	68	1.02	DNR_DAR_24hr
152	11	MA0018.4	CREB1	MA0018.4	NNRTGATGTCAYN	CREB1	0.000155	6.41e-07	23800	33	21600	31.8	1.04	DNR_DAR_24hr
153	18	MA2003.1	NKX2-4	MA2003.1	CCACTTSAVV	NKX2-4	0.000159	6.53e-07	8440	11.7	7390	10.9	1.08	DNR_DAR_24hr
154	28	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	0.000173	7.04e-07	10500	14.5	9250	13.6	1.07	DNR_DAR_24hr
155	21	MA0035.4	GATA1	MA0035.4	NHCTAATCTDH	GATA1	0.000178	7.19e-07	36600	50.8	33600	49.4	1.03	DNR_DAR_24hr
156	27	MA0802.1	TBR1	MA0802.1	AGGTGTGAAA	TBR1	0.000231	9.28e-07	45800	63.6	42300	62.2	1.02	DNR_DAR_24hr
157	5	MA0666.2	MSX1	MA0666.2	SCAATTAR	MSX1	0.000253	1.01e-06	44500	61.8	41100	60.5	1.02	DNR_DAR_24hr
158	21	MA1104.2	GATA6	MA1104.2	HWWTCTTATCTNH	GATA6	0.00026	1.03e-06	16100	22.3	14400	21.2	1.05	DNR_DAR_24hr
159	31	MA0790.1	POU4F1	MA0790.1	ATGMATAATTAATG	POU4F1	0.000272	1.07e-06	28200	39.2	25800	37.9	1.03	DNR_DAR_24hr
160	5	MA0880.1	Dlx3	MA0880.1	NYAATTAN	Dlx3	0.000282	1.11e-06	68600	95.3	64400	94.7	1.01	DNR_DAR_24hr
161	5	MA0882.1	DLX6	MA0882.1	VYAATTAN	DLX6	0.000404	1.57e-06	67800	94.1	63600	93.5	1.01	DNR_DAR_24hr
162	10	MA0495.3	MAFF	MA0495.3	DWGTCAGCATTTTWHN	MAFF	0.000416	1.61e-06	60900	84.6	56900	83.6	1.01	DNR_DAR_24hr
163	5	MA0887.1	EVX1	MA0887.1	VVTAATTABS	EVX1	0.00048	1.85e-06	55400	76.9	51600	75.8	1.01	DNR_DAR_24hr
164	5	MA0726.1	VSX2	MA0726.1	CTAATTAN	VSX2	0.000485	1.85e-06	52500	72.9	48800	71.7	1.02	DNR_DAR_24hr
165	32	MA1562.1	SOX14	MA1562.1	CCGAACAATG	SOX14	0.000505	1.92e-06	52000	72.3	48400	71.1	1.02	DNR_DAR_24hr
166	5	MA0706.1	MEOX2	MA0706.1	DSTAATTAWN	MEOX2	0.000523	1.98e-06	63800	88.7	59700	87.8	1.01	DNR_DAR_24hr
167	9	MA0819.2	CLOCK	MA0819.2	NRACACGTGB	CLOCK	0.000604	2.27e-06	8540	11.9	7510	11	1.07	DNR_DAR_24hr
168	5	MA0723.2	VAX2	MA0723.2	BYAATTAV	VAX2	0.000627	2.34e-06	69100	95.9	64900	95.4	1.01	DNR_DAR_24hr
169	5	MA0700.2	LHX2	MA0700.2	DDCCAATTADN	LHX2	0.000705	2.62e-06	53800	74.7	50000	73.6	1.02	DNR_DAR_24hr
170	12	MA0851.1	Foxj3	MA0851.1	NDAADGTAAACAAANNM	Foxj3	0.000854	3.15e-06	42000	58.3	38800	57.1	1.02	DNR_DAR_24hr
171	33	MA1974.1	ZNF211	MA1974.1	HWYATATACCAYRYW	ZNF211	0.000913	3.35e-06	1890	2.62	1520	2.23	1.18	DNR_DAR_24hr
172	5	MA0716.1	PRRX1	MA0716.1	YYAATTAR	PRRX1	0.00101	3.69e-06	60600	84.1	56600	83.2	1.01	DNR_DAR_24hr
173	31	MA0791.1	POU4F3	MA0791.1	RTGMATWATTAATGAR	POU4F3	0.00103	3.73e-06	33100	46	30400	44.7	1.03	DNR_DAR_24hr
174	5	MA0674.1	NKX6-1	MA0674.1	NTMATTAA	NKX6-1	0.00134	4.84e-06	62600	86.9	58500	86.1	1.01	DNR_DAR_24hr
175	12	MA0613.1	FOXG1	MA0613.1	RTAAACAW	FOXG1	0.00138	4.95e-06	36000	50	33200	48.8	1.03	DNR_DAR_24hr
176	5	MA0725.1	VSX1	MA0725.1	YTAATTAN	VSX1	0.00147	5.22e-06	59900	83.2	55900	82.2	1.01	DNR_DAR_24hr
177	22	MA0077.1	SOX9	MA0077.1	CYATTGTTY	SOX9	0.00147	5.22e-06	68000	94.4	63800	93.8	1.01	DNR_DAR_24hr
178	18	MA0124.2	Nkx3-1	MA0124.2	RCCACTTAA	Nkx3-1	0.00153	5.4e-06	28300	39.4	26000	38.2	1.03	DNR_DAR_24hr
179	27	MA0806.1	TBX4	MA0806.1	AGGTGTGA	TBX4	0.00174	6.1e-06	8570	11.9	7560	11.1	1.07	DNR_DAR_24hr
180	27	MA0807.1	TBX5	MA0807.1	AGGTGTKA	TBX5	0.00237	8.25e-06	7750	10.8	6820	10	1.07	DNR_DAR_24hr
181	18	MA0673.1	NKX2-8	MA0673.1	VCACTTSAV	NKX2-8	0.0025	8.68e-06	12400	17.2	11100	16.3	1.06	DNR_DAR_24hr
182	9	MA0692.1	TFEB	MA0692.1	RYCACGTGAC	TFEB	0.00287	9.89e-06	6010	8.35	5230	7.69	1.09	DNR_DAR_24hr
183	34	MA0606.2	Nfat5	MA0606.2	NNATGGAAAAWN	Nfat5	0.00295	1.01e-05	366	0.51	238	0.35	1.45	DNR_DAR_24hr
184	5	MA1500.1	HOXB6	MA1500.1	BTAATKRC	HOXB6	0.00299	1.02e-05	59700	83	55800	82	1.01	DNR_DAR_24hr
185	12	MA0852.2	FOXK1	MA0852.2	NRDGTAAACAAGNN	FOXK1	0.00346	1.17e-05	54200	75.3	50500	74.2	1.01	DNR_DAR_24hr
186	5	MA1476.2	Dlx5	MA1476.2	NDGCAATTAGNN	Dlx5	0.00391	1.32e-05	63700	88.4	59600	87.7	1.01	DNR_DAR_24hr
187	5	MA0648.1	GSC	MA0648.1	VYTAATCCSY	GSC	0.00565	1.9e-05	55300	76.8	51600	75.8	1.01	DNR_DAR_24hr
188	5	MA0892.1	GSX1	MA0892.1	NCYMATTAVN	GSX1	0.00636	2.12e-05	68900	95.6	64700	95.2	1.01	DNR_DAR_24hr
189	27	MA0805.1	TBX1	MA0805.1	AGGTGTGA	TBX1	0.0064	2.13e-05	24700	34.4	22600	33.3	1.03	DNR_DAR_24hr
190	5	MA0890.1	GBX2	MA0890.1	RSYAATTARN	GBX2	0.00758	2.5e-05	54500	75.7	50800	74.7	1.01	DNR_DAR_24hr
191	18	MA0885.2	Dlx2	MA0885.2	NDGCAATTAGNN	Dlx2	0.0079	2.59e-05	65200	90.5	61100	89.8	1.01	DNR_DAR_24hr
192	11	MA0488.1	JUN	MA0488.1	DDRATGATGTCAT	JUN	0.00826	2.7e-05	13800	19.2	12500	18.3	1.05	DNR_DAR_24hr
193	26	MA0899.1	HOXA10	MA0899.1	DGYMATAAAAH	HOXA10	0.00837	2.72e-05	60400	83.9	56500	83	1.01	DNR_DAR_24hr
194	9	MA1994.1	Nkx2-1	MA1994.1	NVCACTTGARHNN	Nkx2-1	0.00905	2.93e-05	55800	77.4	52000	76.5	1.01	DNR_DAR_24hr
195	13	MA0829.2	SREBF1	MA0829.2	DNATCACSTGATNH	SREBF1	0.00991	3.19e-05	8360	11.6	7410	10.9	1.07	DNR_DAR_24hr
196	5	MA0721.1	UNCX	MA0721.1	YYAATTAV	UNCX	0.0101	3.23e-05	55200	76.6	51500	75.7	1.01	DNR_DAR_24hr
197	22	MA0143.4	SOX2	MA0143.4	DNACAATGGNN	SOX2	0.0119	3.79e-05	63800	88.6	59700	87.8	1.01	DNR_DAR_24hr
198	22	MA1152.1	SOX15	MA1152.1	CYWTTGTTHW	SOX15	0.012	3.82e-05	67600	93.9	63500	93.4	1.01	DNR_DAR_24hr
199	5	MA1496.1	HOXA4	MA1496.1	RTMATTAV	HOXA4	0.013	4.1e-05	57600	80	53800	79.1	1.01	DNR_DAR_24hr
200	12	MA0850.1	FOXP3	MA0850.1	RTAAACA	FOXP3	0.0154	4.83e-05	63500	88.1	59400	87.4	1.01	DNR_DAR_24hr
201	5	MA1549.1	POU6F1	MA1549.1	RTAATGAGVN	POU6F1	0.0159	4.98e-05	22000	30.6	20100	29.6	1.03	DNR_DAR_24hr
202	5	MA0888.1	EVX2	MA0888.1	VVTAATTAVB	EVX2	0.0172	5.33e-05	60900	84.6	57000	83.8	1.01	DNR_DAR_24hr
203	31	MA0153.2	HNF1B	MA0153.2	GTTAATNATTAAY	HNF1B	0.0178	5.52e-05	17700	24.6	16100	23.6	1.04	DNR_DAR_24hr
204	5	MA0889.1	GBX1	MA0889.1	VCYAATTASY	GBX1	0.0208	6.4e-05	51400	71.4	47900	70.4	1.01	DNR_DAR_24hr
205	12	MA0041.2	FOXD3	MA0041.2	WAWGHAAATAAACARY	FOXD3	0.0211	6.47e-05	46900	65.2	43600	64.1	1.02	DNR_DAR_24hr
206	9	MA1620.1	Ptf1A	MA1620.1	NVACACCTGTNN	Ptf1A	0.0233	7.1e-05	43100	59.8	40000	58.8	1.02	DNR_DAR_24hr
207	9	MA0664.1	MLXIPL	MA0664.1	RTCACGTGAT	MLXIPL	0.0246	7.45e-05	18000	24.9	16300	24	1.04	DNR_DAR_24hr
208	10	MA0775.1	MEIS3	MA0775.1	DTGACAGS	MEIS3	0.0261	7.87e-05	2490	3.46	2090	3.07	1.12	DNR_DAR_24hr
209	12	MA0030.1	FOXF2	MA0030.1	BNAASGTAAACAAD	FOXF2	0.028	8.41e-05	7950	11	7060	10.4	1.06	DNR_DAR_24hr
210	5	MA0793.1	POU6F2	MA0793.1	ASCTMATTAW	POU6F2	0.04	0.00012	32700	45.5	30200	44.4	1.02	DNR_DAR_24hr
16	35	MA1125.1 (ZNF384)	MEME-1	AAAAAAAAAAAAAAA	AAAAAAAAAAAAAAA	ZNF384	8.9	0.556	2650	3.68	2500	3.68	1	DNR_DAR_24hr
17	36	MA1723.1 (PRDM9)	MEME-4	CYCYYCCTCCYTCYC	CYCYYCCTCCYTCYC	PRDM9	16.5	0.968	6	0.01	10	0.01	0.601	DNR_DAR_24hr
18	36	MA1961.1 (PATZ1)	MEME-3	GSGGSSGGGGCGGGG	GSGGSSGGGGCGGGG	PATZ1	17.9	0.996	55	0.08	81	0.12	0.645	DNR_DAR_24hr

ER_rat <- 1.25
mrc_type <- "DNR_DAR_24hr"
DNR_DAR_24hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DNR_DAR_24hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  dplyr::filter(EVALUE.y<0.05) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*.8), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.8,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DNR_DAR 24 2kb data

DNR_242kb_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_24_2kb_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DNR_242kb_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_24_2kb_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DNR_242kb_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_24_2kb_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DNR_242kb_sea_all <- rbind(DNR_242kb_sea_disc, DNR_242kb_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DNR_242kb_combo <- DNR_242kb_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DNR_242kb_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

DNR_242kb_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in DNR_24 2kb") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in DNR_24 2kb
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA1134.1 (FOS::JUNB)	STREME-1	1-DATGASTCATH	DATGASTCATH	FOS::JUNB	2.11e-78	9.15e-79	1020	6.3	362	2.16	2.91
2	1	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	6.33e-71	1.38e-71	1380	8.5	630	3.76	2.26
3	1	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	2.42e-68	3.51e-69	1240	7.63	543	3.24	2.35
4	1	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	8.3e-67	9.02e-68	1500	9.25	738	4.4	2.1
5	1	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	3.82e-65	3.32e-66	961	5.94	371	2.21	2.68
6	1	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	7.69e-65	5.57e-66	1020	6.29	409	2.44	2.57
7	1	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	3.05e-64	1.9e-65	1020	6.33	416	2.48	2.55
8	1	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	1.13e-63	6.15e-65	911	5.63	344	2.05	2.74
9	1	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	2.85e-63	1.38e-64	1140	7.06	501	2.99	2.36
10	1	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	1.24e-61	5.38e-63	1200	7.44	551	3.29	2.26
11	1	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	3.25e-61	1.28e-62	1010	6.26	420	2.51	2.49
12	1	MA0477.2 (FOSL1)	MEME-6	TGAGTCAT	TGAGTCAT	FOSL1	1.58e-59	5.73e-61	1270	7.83	606	3.62	2.16
13	1	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	1.41e-58	4.7e-60	1090	6.75	486	2.9	2.32
14	1	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	3.01e-58	9.34e-60	837	5.17	316	1.89	2.74
15	1	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	7.97e-58	2.31e-59	715	4.42	241	1.44	3.06
16	1	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	2.37e-57	6.44e-59	796	4.92	293	1.75	2.81
17	1	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	6.46e-57	1.65e-58	874	5.4	345	2.06	2.62
18	1	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	1.3e-55	3.13e-57	750	4.64	270	1.61	2.87
19	1	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	2.63e-53	6.02e-55	699	4.32	246	1.47	2.94
20	1	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	5.48e-52	1.19e-53	977	6.04	435	2.6	2.32
21	1	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	1.21e-50	2.5e-52	713	4.41	264	1.58	2.79
22	1	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	4.44e-50	8.77e-52	1140	7.03	559	3.34	2.11
23	1	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	5.29e-50	9.99e-52	785	4.85	313	1.87	2.59
24	1	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	2.65e-49	4.8e-51	755	4.67	296	1.77	2.64
25	1	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	8.4e-49	1.46e-50	660	4.08	237	1.41	2.88
26	1	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	4.52e-43	7.55e-45	848	5.24	385	2.3	2.28
27	1	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	2.45e-37	3.94e-39	584	3.61	230	1.37	2.62
28	1	3-AGACATM	STREME-3	3-AGACATM	AGACATM	AGACATM	4.44e-29	6.9e-31	3880	24	3130	18.7	1.28
29	1	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	8.36e-28	1.25e-29	448	2.77	178	1.06	2.6
30	1	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	8.29e-27	1.2e-28	1420	8.78	935	5.58	1.57
31	1	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	1.82e-25	2.55e-27	3240	20	2580	15.4	1.3
32	2	MA0502.2 (NFYB)	STREME-4	4-CATTGGC	CATTGGC	NFYB	3.72e-20	5.05e-22	6400	39.5	5750	34.3	1.15
33	1	MA0150.2	Nfe2l2	MA0150.2	CASNATGACTCAGCA	Nfe2l2	1.02e-19	1.34e-21	4410	27.3	3790	22.6	1.21
34	1	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	5.04e-19	6.45e-21	3400	21	2830	16.9	1.24
35	3	MA0705.1	Lhx8	MA0705.1	CTAATTAV	Lhx8	8.08e-19	1e-20	7600	47	7000	41.8	1.12
36	3	MA0904.2	HOXB5	MA0904.2	STAATTAS	HOXB5	8.36e-18	1.01e-19	8680	53.7	8140	48.6	1.11
37	4	7-CATGTCA	STREME-7	7-CATGTCA	CATGTCA	CATGTCA	1.28e-17	1.5e-19	8090	50	7530	45	1.11
38	3	MA1530.1	NKX6-3	MA1530.1	VYCATTAWW	NKX6-3	1.09e-16	1.25e-18	7520	46.5	6970	41.6	1.12
39	3	MA1519.1	LHX5	MA1519.1	STAATTAV	LHX5	6.75e-16	7.52e-18	4830	29.8	4270	25.5	1.17
40	5	MA0774.1 (MEIS2)	STREME-2	2-CTGTCA	CTGTCA	MEIS2	1.55e-15	1.68e-17	11900	73.5	11600	69.2	1.06
41	3	MA1495.1	HOXA1	MA1495.1	STAATTAS	HOXA1	2.42e-15	2.57e-17	7320	45.3	6790	40.5	1.12
42	2	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	3.37e-15	3.49e-17	9710	60	9270	55.3	1.08
43	3	MA0707.2	MNX1	MA0707.2	VYRATTAK	MNX1	1.3e-14	1.32e-16	6810	42.1	6290	37.6	1.12
44	6	MA1107.2 (KLF9)	STREME-8	8-GTGTGTGTGYATG	GTGTGTGTGYATG	KLF9	1.78e-14	1.76e-16	308	1.9	140	0.84	2.27
45	5	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	2.08e-14	2.01e-16	7740	47.9	7250	43.2	1.11
46	7	MA1990.1 (Gli1)	STREME-5	5-ACACACCACACAC	ACACACCACACAC	Gli1	3.05e-14	2.88e-16	124	0.77	27	0.16	4.62
47	3	MA0900.2	HOXA2	MA0900.2	STAATTAS	HOXA2	3.81e-13	3.52e-15	4480	27.7	3980	23.8	1.16
48	3	MA0661.1	MEOX1	MA0661.1	VSTAATTAHC	MEOX1	4.6e-13	4.17e-15	5770	35.7	5280	31.5	1.13
49	8	MA0620.3	MITF	MA0620.3	NNNDRTCACGTGAYHNNN	MITF	5.47e-13	4.85e-15	8140	50.3	7690	45.9	1.1
50	1	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	1.04e-12	9.02e-15	8700	53.8	8280	49.4	1.09
51	3	MA0666.2	MSX1	MA0666.2	SCAATTAR	MSX1	2.2e-12	1.87e-14	9450	58.4	9070	54.1	1.08
52	3	MA0027.2	EN1	MA0027.2	SYAATTAV	EN1	2.55e-12	2.13e-14	9580	59.2	9210	55	1.08
53	3	MA0706.1	MEOX2	MA0706.1	DSTAATTAWN	MEOX2	3.06e-12	2.51e-14	7960	49.2	7520	44.9	1.1
54	8	MA0093.3	USF1	MA0093.3	NDGTCATGTGACHN	USF1	5.32e-12	4.28e-14	10600	65.6	10300	61.5	1.07
55	9	MA0077.1	SOX9	MA0077.1	CYATTGTTY	SOX9	7.03e-12	5.56e-14	8060	49.8	7640	45.6	1.09
56	3	MA0704.1	Lhx4	MA0704.1	YTAATTAR	Lhx4	7.27e-12	5.65e-14	9370	57.9	9000	53.7	1.08
57	2	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	2e-11	1.53e-13	9410	58.2	9050	54	1.08
58	3	MA0630.1	SHOX	MA0630.1	HTAATTRR	SHOX	2.72e-11	2.04e-13	8960	55.4	8590	51.2	1.08
59	3	MA1502.1	HOXB8	MA1502.1	GYMATTAM	HOXB8	3.23e-11	2.38e-13	7030	43.5	6600	39.4	1.1
60	3	MA1549.1	POU6F1	MA1549.1	RTAATGAGVN	POU6F1	4.74e-11	3.4e-13	6910	42.7	6480	38.7	1.1
61	10	MA0142.1	Pou5f1::Sox2	MA0142.1	CWTTGTYATGCAAAT	Pou5f1::Sox2	4.81e-11	3.4e-13	10100	62.5	9800	58.5	1.07
62	3	MA0902.2	HOXB2	MA0902.2	SYAATTAS	HOXB2	4.85e-11	3.4e-13	6420	39.7	5990	35.7	1.11
63	3	MA0718.1	RAX	MA0718.1	RYYAATTARH	RAX	5.03e-11	3.47e-13	8820	54.6	8460	50.5	1.08
64	3	MA0726.1	VSX2	MA0726.1	CTAATTAN	VSX2	7.83e-11	5.26e-13	8890	54.9	8530	50.9	1.08
65	3	MA1481.1	DRGX	MA1481.1	YYAATTAN	DRGX	7.86e-11	5.26e-13	7510	46.4	7100	42.4	1.1
66	3	MA0725.1	VSX1	MA0725.1	YTAATTAN	VSX1	9.17e-11	6.04e-13	5970	36.9	5540	33	1.12
67	8	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	1.23e-10	8.01e-13	5470	33.8	5040	30	1.12
68	3	MA0888.1	EVX2	MA0888.1	VVTAATTAVB	EVX2	1.44e-10	9.22e-13	8540	52.8	8170	48.8	1.08
69	3	MA1476.2	Dlx5	MA1476.2	NDGCAATTAGNN	Dlx5	1.79e-10	1.12e-12	9750	60.2	9440	56.3	1.07
70	3	MA0882.1	DLX6	MA0882.1	VYAATTAN	DLX6	1.97e-10	1.23e-12	7920	49	7540	45	1.09
71	1	MA1639.1	MEIS1	MA1639.1	NHCATMAATCAHN	MEIS1	2.28e-10	1.4e-12	3710	23	3300	19.7	1.17
72	3	MA0710.1	NOTO	MA0710.1	NYTAATTAVN	NOTO	2.48e-10	1.5e-12	7390	45.7	6990	41.7	1.09
73	3	MA0879.2	DLX1	MA0879.2	VYAATTAN	DLX1	2.94e-10	1.75e-12	8590	53.1	8240	49.2	1.08
74	11	MA0063.2	NKX2-5	MA0063.2	NNCACTCAANN	NKX2-5	3.57e-10	2.1e-12	10600	65.3	10300	61.5	1.06
75	3	MA0912.2	HOXD3	MA0912.2	CTAATTAC	HOXD3	4.54e-10	2.63e-12	4140	25.6	3730	22.2	1.15
76	3	MA0709.1	Msx3	MA0709.1	SCAATTAN	Msx3	4.89e-10	2.8e-12	7670	47.4	7290	43.5	1.09
77	3	MA0886.1	EMX2	MA0886.1	VBTAATTARB	EMX2	5.01e-10	2.83e-12	4730	29.2	4310	25.7	1.14
78	3	MA0708.2	MSX2	MA0708.2	SCAATTAV	MSX2	5.14e-10	2.87e-12	10600	65.3	10300	61.5	1.06
79	3	MA0644.2	ESX1	MA0644.2	YYAATTAN	ESX1	6.78e-10	3.71e-12	5280	32.6	4860	29	1.12
80	3	MA0722.1	VAX1	MA0722.1	YTAATTAH	VAX1	6.83e-10	3.71e-12	7480	46.2	7100	42.4	1.09
81	12	6-CYACAMHCAH	STREME-6	6-CYACAMHCAH	CYACAMHCAH	CYACAMHCAH	8.61e-10	4.62e-12	3180	19.7	2800	16.7	1.18
82	3	MA0658.1	LHX6	MA0658.1	RCTAATTARY	LHX6	9.25e-10	4.91e-12	7600	46.9	7220	43.1	1.09
83	3	MA0889.1	GBX1	MA0889.1	VCYAATTASY	GBX1	1.04e-09	5.44e-12	8320	51.4	7960	47.5	1.08
84	3	MA0885.2	Dlx2	MA0885.2	NDGCAATTAGNN	Dlx2	1.14e-09	5.91e-12	9200	56.9	8890	53	1.07
85	3	MA0853.1	Alx4	MA0853.1	CGCRYTAATTARYHNNY	Alx4	1.64e-09	8.37e-12	5930	36.7	5530	33	1.11
86	8	MA0018.4	CREB1	MA0018.4	NNRTGATGTCAYN	CREB1	1.66e-09	8.39e-12	9140	56.5	8820	52.6	1.07
87	3	MA0887.1	EVX1	MA0887.1	VVTAATTABS	EVX1	1.7e-09	8.5e-12	7840	48.5	7480	44.6	1.09
88	9	MA1562.1	SOX14	MA1562.1	CCGAACAATG	SOX14	3.16e-09	1.56e-11	7050	43.6	6670	39.8	1.09
89	3	MA1500.1	HOXB6	MA1500.1	BTAATKRC	HOXB6	3.35e-09	1.64e-11	12400	76.6	12300	73.3	1.04
90	3	MA1518.2	Lhx1	MA1518.2	NNNTGCTAATTAGCANNN	Lhx1	4.39e-09	2.12e-11	7760	48	7410	44.2	1.08
91	6	MA1107.2 (KLF9)	MEME-4	TGTGTGTGTGTRTGT	TGTGTGTGTGTRTGT	KLF9	4.93e-09	2.36e-11	942	5.82	702	4.19	1.39
92	13	MA0070.1	PBX1	MA0070.1	HCATCAATCAAW	PBX1	6.49e-09	3.07e-11	6230	38.5	5850	34.9	1.1
93	3	MA0854.1	Alx1	MA0854.1	CGMRYTAATTARTNMNY	Alx1	7.32e-09	3.42e-11	5180	32	4800	28.6	1.12
94	3	MA0720.1	Shox2	MA0720.1	YYAATTAR	Shox2	7.71e-09	3.56e-11	10200	63.3	10000	59.7	1.06
95	3	MA0675.1	NKX6-2	MA0675.1	NYMATTAA	NKX6-2	9.15e-09	4.19e-11	9300	57.5	9020	53.8	1.07
96	3	MA0642.2	EN2	MA0642.2	VSYAATTA	EN2	1.15e-08	5.2e-11	9280	57.4	9000	53.7	1.07
97	16	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	1.17e-08	5.26e-11	4010	24.8	3630	21.7	1.14
98	14	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	1.37e-08	6.08e-11	10800	67	10600	63.6	1.05
99	15	MA0842.2	NRL	MA0842.2	AAWWNTGCTGACG	NRL	1.46e-08	6.4e-11	2960	18.3	2610	15.6	1.18
100	3	MA1505.1	HOXC8	MA1505.1	KTAATTAM	HOXC8	1.49e-08	6.47e-11	11500	71.3	11400	67.9	1.05
101	3	MA0701.2	LHX9	MA0701.2	CYAATTAR	LHX9	1.87e-08	8.04e-11	3380	20.9	3020	18	1.16
102	16	MA0742.2 (KLF12)	STREME-9	9-AGGCCCCGCCC	AGGCCCCGCCC	KLF12	1.96e-08	8.35e-11	1200	7.43	944	5.63	1.32
103	3	MA0654.1	ISX	MA0654.1	YYAATTAR	ISX	2.3e-08	9.71e-11	6610	40.9	6260	37.3	1.09
104	3	MA0158.2	HOXA5	MA0158.2	GYMATTAS	HOXA5	2.54e-08	1.06e-10	4540	28.1	4170	24.9	1.13
105	1	MA1113.2	PBX2	MA1113.2	NHCATAAATCAHN	PBX2	3.27e-08	1.35e-10	6470	40	6110	36.5	1.1
106	3	MA0893.2	GSX2	MA0893.2	SYMATTAR	GSX2	3.41e-08	1.4e-10	5360	33.1	4990	29.8	1.11
107	3	MA0881.1	Dlx4	MA0881.1	VYAATTAN	Dlx4	3.49e-08	1.42e-10	6920	42.8	6580	39.2	1.09
108	11	MA1645.1	NKX2-2	MA1645.1	NNNCCACTCAANNN	NKX2-2	4.31e-08	1.74e-10	15400	95.1	15700	93.4	1.02
109	3	MA0723.2	VAX2	MA0723.2	BYAATTAV	VAX2	5.33e-08	2.13e-10	8370	51.8	8080	48.2	1.07
110	3	MA0721.1	UNCX	MA0721.1	YYAATTAV	UNCX	6.45e-08	2.55e-10	9660	59.7	9420	56.2	1.06
111	16	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	7.52e-08	2.94e-10	1310	8.08	1050	6.27	1.29
112	3	MA0717.1	RAX2	MA0717.1	YYAATTAV	RAX2	7.61e-08	2.95e-10	9040	55.9	8780	52.4	1.07
113	3	MA0700.2	LHX2	MA0700.2	DDCCAATTADN	LHX2	8.78e-08	3.38e-10	8640	53.4	8360	49.9	1.07
114	3	MA1463.1	ARGFX	MA1463.1	DCTAATTARM	ARGFX	8.9e-08	3.39e-10	5310	32.8	4960	29.6	1.11
115	3	MA0713.1	PHOX2A	MA0713.1	TAATYYAATTA	PHOX2A	9.99e-08	3.78e-10	6670	41.2	6330	37.8	1.09
116	3	MA0890.1	GBX2	MA0890.1	RSYAATTARN	GBX2	1.02e-07	3.82e-10	4950	30.6	4590	27.4	1.12
117	14	MA0042.2	FOXI1	MA0042.2	GTAAACA	FOXI1	1.53e-07	5.68e-10	8720	53.9	8460	50.5	1.07
118	17	MA1124.1	ZNF24	MA1124.1	CATTCATTCATTC	ZNF24	2.45e-07	9.04e-10	4850	30	4500	26.9	1.11
119	3	MA0793.1	POU6F2	MA0793.1	ASCTMATTAW	POU6F2	2.51e-07	9.17e-10	7070	43.7	6760	40.3	1.08
120	5	MA1114.1	PBX3	MA1114.1	NNNTGAGTGACAGGBNN	PBX3	2.81e-07	1.02e-09	4930	30.5	4590	27.4	1.11
121	14	MA0032.2	FOXC1	MA0032.2	WAWGTAAAYAW	FOXC1	2.84e-07	1.02e-09	10300	63.8	10100	60.5	1.05
122	8	MA1126.1	FOS::JUN	MA1126.1	DRTGACGTCATHNDTN	FOS::JUN	3.45e-07	1.23e-09	7170	44.3	6860	41	1.08
123	10	MA1115.1	POU5F1	MA1115.1	WHATGCAAATN	POU5F1	3.64e-07	1.29e-09	5580	34.5	5240	31.3	1.1
124	3	MA0680.2	Pax7	MA0680.2	DWTAATCAATTAWNH	Pax7	3.93e-07	1.36e-09	8150	50.4	7880	47	1.07
125	18	MA0483.1	Gfi1B	MA0483.1	AAATCWCWGCH	Gfi1B	3.93e-07	1.36e-09	3410	21	3080	18.4	1.15
126	11	MA0122.3	Nkx3-2	MA0122.3	WWAAMCACTTAAN	Nkx3-2	3.95e-07	1.36e-09	6750	41.7	6430	38.4	1.09
127	19	MA1963.1	SATB1	MA1963.1	WWDCTAATAAHWW	SATB1	4.66e-07	1.6e-09	8560	52.9	8300	49.5	1.07
128	20	MA1960.1	MGA::EVX1	MA1960.1	RGGTGWTAATKD	MGA::EVX1	5.7e-07	1.94e-09	10300	63.6	10100	60.4	1.05
129	14	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	6.15e-07	2.07e-09	9410	58.2	9190	54.8	1.06
130	3	MA0612.2	EMX1	MA0612.2	BTAATTAS	EMX1	6.99e-07	2.34e-09	5120	31.6	4790	28.6	1.11
131	3	MA0634.1	ALX3	MA0634.1	YYYAATTANV	ALX3	7.55e-07	2.51e-09	8580	53	8330	49.7	1.07
132	21	MA0611.2	Dux	MA0611.2	NTGATTBAATCAVWNN	Dux	8.19e-07	2.7e-09	3760	23.2	3440	20.5	1.13
133	9	MA0143.4	SOX2	MA0143.4	DNACAATGGNN	SOX2	1.2e-06	3.94e-09	11000	68.2	10900	65.1	1.05
134	3	MA0681.2	PHOX2B	MA0681.2	WWTAATCAAATTAWWW	PHOX2B	1.24e-06	4.04e-09	7220	44.6	6930	41.4	1.08
135	22	MA1974.1	ZNF211	MA1974.1	HWYATATACCAYRYW	ZNF211	1.42e-06	4.57e-09	4180	25.8	3860	23	1.12
136	15	MA0495.3	MAFF	MA0495.3	DWGTCAGCATTTTWHN	MAFF	1.73e-06	5.53e-09	5770	35.6	5460	32.6	1.09
137	3	MA0880.1	Dlx3	MA0880.1	NYAATTAN	Dlx3	1.95e-06	6.2e-09	6230	38.5	5930	35.4	1.09
138	14	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	2.01e-06	6.34e-09	8370	51.7	8120	48.5	1.07
139	11	MA1523.1	MSANTD3	MA1523.1	STVCACTCAC	MSANTD3	2.07e-06	6.46e-09	13800	85.6	13900	83.2	1.03
140	3	MA0699.1	LBX2	MA0699.1	NCYAATTARN	LBX2	2.27e-06	7.04e-09	10000	61.9	9840	58.7	1.05
141	1	MA1640.1	MEIS2	MA1640.1	NNATGATTTATGDNH	MEIS2	2.61e-06	8.05e-09	6320	39.1	6030	36	1.09
142	3	MA0662.1	MIXL1	MA0662.1	NBYAATTAVN	MIXL1	3.03e-06	9.26e-09	10200	63	10000	59.9	1.05
143	10	MA0785.1	POU2F1	MA0785.1	AWTATGCWAATK	POU2F1	3.8e-06	1.16e-08	9190	56.8	8990	53.6	1.06
144	14	MA0614.1	Foxj2	MA0614.1	RTAAACAA	Foxj2	4.44e-06	1.34e-08	6620	40.9	6340	37.8	1.08
145	23	MA0676.1	Nr2e1	MA0676.1	AAAAGTCAA	Nr2e1	5.04e-06	1.51e-08	6850	42.3	6570	39.2	1.08
146	3	MA0075.3	PRRX2	MA0075.3	CTAATTAN	PRRX2	6.48e-06	1.93e-08	4570	28.2	4270	25.5	1.11
147	3	MA0648.1	GSC	MA0648.1	VYTAATCCSY	GSC	9.84e-06	2.91e-08	7300	45.1	7050	42	1.07
148	14	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	1.01e-05	2.96e-08	9860	61	9710	57.9	1.05
149	13	MA0679.2	ONECUT1	MA0679.2	WAAAAATCAATAAWWN	ONECUT1	1.21e-05	3.54e-08	7460	46.1	7220	43.1	1.07
150	14	MA0481.3	FOXP1	MA0481.3	NDGTAAACANH	FOXP1	1.43e-05	4.16e-08	8940	55.3	8750	52.2	1.06
151	24	MA1572.1	TGIF2LY	MA1572.1	TGACAGCTGTCA	TGIF2LY	1.48e-05	4.25e-08	10200	63.3	10100	60.4	1.05
152	25	MA0025.2	NFIL3	MA0025.2	NRTTATGYAATNN	NFIL3	1.52e-05	4.35e-08	8110	50.1	7890	47.1	1.06
153	8	MA1145.1	FOSL2::JUND	MA1145.1	NNRTGACGTCAYHSN	FOSL2::JUND	1.69e-05	4.79e-08	5420	33.5	5140	30.6	1.09
154	16	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	1.9e-05	5.38e-08	2790	17.3	2520	15	1.15
155	19	MA0035.4	GATA1	MA0035.4	NHCTAATCTDH	GATA1	2.14e-05	5.99e-08	3330	20.6	3050	18.2	1.13
156	19	MA0712.2	OTX2	MA0712.2	NDRGGATTARNN	OTX2	2.24e-05	6.24e-08	11900	73.8	11900	71.1	1.04
157	26	MA1155.1	ZSCAN4	MA1155.1	TGCACACACTGAAAA	ZSCAN4	2.44e-05	6.76e-08	344	2.13	225	1.34	1.58
158	27	MA0899.1	HOXA10	MA0899.1	DGYMATAAAAH	HOXA10	2.87e-05	7.88e-08	8500	52.5	8300	49.5	1.06
159	28	MA1707.1	DMRTA1	MA1707.1	AWTTGWTACAWT	DMRTA1	3e-05	8.2e-08	9940	61.4	9800	58.5	1.05
160	3	MA0894.1	HESX1	MA0894.1	GHTAATTRRH	HESX1	3.05e-05	8.29e-08	6570	40.6	6320	37.7	1.08
161	9	MA1120.1	SOX13	MA1120.1	DVACAATGGNN	SOX13	3.39e-05	9.16e-08	7190	44.4	6960	41.5	1.07
162	29	MA0461.2	Atoh1	MA0461.2	RMCATATGBY	Atoh1	3.61e-05	9.68e-08	12200	75.5	12200	72.9	1.04
163	30	MA0847.3	FOXD2	MA0847.3	SYTAARYAAACA	FOXD2	3.81e-05	1.02e-07	7300	45.1	7070	42.2	1.07
164	31	MA0790.1	POU4F1	MA0790.1	ATGMATAATTAATG	POU4F1	3.9e-05	1.03e-07	4840	29.9	4560	27.2	1.1
165	32	MA0861.1	TP73	MA0861.1	DRCATGTCNNRACAYGYM	TP73	4.12e-05	1.09e-07	689	4.26	527	3.14	1.35
166	30	MA1487.2	FOXE1	MA1487.2	VYTAAAYAAACAAH	FOXE1	4.27e-05	1.1e-07	7650	47.3	7430	44.3	1.07
167	24	MA1571.1	TGIF2LX	MA1571.1	TGACAGCTGTCA	TGIF2LX	4.28e-05	1.1e-07	9190	56.8	9020	53.8	1.05
168	3	MA0788.1	POU3F3	MA0788.1	WWTATGCWAATTW	POU3F3	4.28e-05	1.1e-07	7740	47.9	7530	44.9	1.07
169	33	MA0754.2	CUX1	MA0754.2	TAATCGATAM	CUX1	4.29e-05	1.1e-07	5750	35.6	5490	32.8	1.09
170	3	MA0716.1	PRRX1	MA0716.1	YYAATTAR	PRRX1	4.43e-05	1.13e-07	10300	63.5	10200	60.6	1.05
171	8	MA1632.1	ATF2	MA1632.1	NNATGABGTCATN	ATF2	4.57e-05	1.16e-07	2930	18.1	2670	15.9	1.14
172	16	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	4.94e-05	1.25e-07	1380	8.51	1160	6.95	1.23
173	14	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	5.24e-05	1.32e-07	11000	68.3	11000	65.5	1.04
174	33	MA0755.1	CUX2	MA0755.1	TRATCGATAW	CUX2	5.33e-05	1.33e-07	4560	28.2	4290	25.6	1.1
175	13	MA0896.1	Hmx1	MA0896.1	VSVAGCAATTAAWGVDB	Hmx1	5.42e-05	1.35e-07	5570	34.4	5310	31.7	1.09
176	34	MA1978.1	ZNF354A	MA1978.1	HWAADWATAAATGRAYWAWTT	ZNF354A	5.58e-05	1.38e-07	6300	38.9	6050	36.1	1.08
177	35	MA1480.1	DPRX	MA1480.1	AGATAATCCN	DPRX	5.63e-05	1.38e-07	7560	46.7	7340	43.8	1.07
178	8	MA1133.1	JUN::JUNB	MA1133.1	KRTGACGTCATN	JUN::JUNB	5.98e-05	1.46e-07	6240	38.6	5990	35.8	1.08
179	24	MA0797.1	TGIF2	MA0797.1	TGACAGSTGTCA	TGIF2	6.62e-05	1.61e-07	4510	27.9	4240	25.3	1.1
180	14	MA0041.2	FOXD3	MA0041.2	WAWGHAAATAAACARY	FOXD3	6.65e-05	1.61e-07	6760	41.8	6520	38.9	1.07
181	14	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	6.79e-05	1.63e-07	5800	35.8	5540	33.1	1.08
182	3	MA0628.1	POU6F1	MA0628.1	AYTAATTART	POU6F1	8.45e-05	2.02e-07	10400	64.4	10300	61.6	1.05
183	36	MA0069.1	PAX6	MA0069.1	TTCACGCWTSANTK	PAX6	0.000103	2.45e-07	6240	38.6	6000	35.8	1.08
184	19	MA1608.1	Isl1	MA1608.1	NNCCATTAGNN	Isl1	0.000104	2.45e-07	7020	43.4	6800	40.6	1.07
185	8	MA1129.1	FOSL1::JUN	MA1129.1	ATGACGTCAT	FOSL1::JUN	0.000107	2.51e-07	13000	80.1	13000	77.7	1.03
186	13	MA0897.1	Hmx2	MA0897.1	ASAAGCAATTAAHVVRT	Hmx2	0.000119	2.78e-07	5540	34.2	5290	31.6	1.08
187	15	MA0117.2	Mafb	MA0117.2	AWWNTGCTGACD	Mafb	0.000128	2.98e-07	1610	9.96	1400	8.32	1.2
188	8	MA1524.2	Msgn1	MA1524.2	VRRRACAAATGGTNNN	Msgn1	0.000165	3.82e-07	7740	47.8	7550	45.1	1.06
189	19	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	0.000167	3.85e-07	1010	6.24	829	4.95	1.26
190	3	MA0791.1	POU4F3	MA0791.1	RTGMATWATTAATGAR	POU4F3	0.000184	4.21e-07	4140	25.6	3890	23.2	1.1
191	3	MA0903.1	HOXB3	MA0903.1	NNYMATTARN	HOXB3	0.000195	4.43e-07	9090	56.2	8950	53.4	1.05
192	37	MA0808.1	TEAD3	MA0808.1	RCATTCCW	TEAD3	0.000237	5.36e-07	6290	38.9	6070	36.2	1.07
193	3	MA0674.1	NKX6-1	MA0674.1	NTMATTAA	NKX6-1	0.00024	5.41e-07	11200	69.4	11200	66.8	1.04
194	9	MA0084.1	SRY	MA0084.1	NWWAACAAT	SRY	0.000286	6.4e-07	12600	78	12700	75.6	1.03
195	8	MA1618.1	Ptf1a	MA1618.1	NNACAGATGTTNN	Ptf1a	0.000287	6.4e-07	14400	89	14600	87.2	1.02
196	8	MA0609.2	CREM	MA0609.2	NNDGTGACGTCACHNN	CREM	0.000308	6.82e-07	7550	46.7	7360	43.9	1.06
197	28	MA1478.1	DMRTA2	MA1478.1	AATTGHTACAWT	DMRTA2	0.000409	9.02e-07	7100	43.9	6900	41.2	1.06
198	38	MA0596.1	SREBF2	MA0596.1	RTGGGGTGAY	SREBF2	0.000554	1.22e-06	1220	7.51	1030	6.16	1.22
199	3	MA1501.1	HOXB7	MA1501.1	GGTAATTAVS	HOXB7	0.000569	1.24e-06	7510	46.4	7340	43.8	1.06
200	3	MA0786.1	POU3F1	MA0786.1	WTATGCWAATKW	POU3F1	0.000683	1.48e-06	6030	37.3	5820	34.7	1.07
201	10	MA0789.1	POU3F4	MA0789.1	TATGCWAAT	POU3F4	0.000709	1.53e-06	5890	36.4	5680	33.9	1.07
202	9	MA0868.2	SOX8	MA0868.2	MGAACAATRG	SOX8	0.000744	1.6e-06	10100	62.4	10000	59.8	1.04
203	5	MA0775.1	MEIS3	MA0775.1	DTGACAGS	MEIS3	0.000749	1.6e-06	4800	29.6	4570	27.3	1.09
204	10	MA0627.2	POU2F3	MA0627.2	NWTATGCAAATNH	POU2F3	0.00075	1.6e-06	6330	39.1	6130	36.6	1.07
205	10	MA0792.1	POU5F1B	MA0792.1	TATGCWAAT	POU5F1B	0.000792	1.68e-06	5430	33.6	5210	31.1	1.08
206	39	MA1151.1	RORC	MA1151.1	NWAWNTRGGTCA	RORC	0.00087	1.84e-06	10900	67.6	10900	65.1	1.04
207	1	MA1633.2 (BACH1)	MEME-5	TGRCTCATGCCTGTA	TGRCTCATGCCTGTA	BACH1	0.000894	1.88e-06	565	3.49	434	2.59	1.35
208	3	MA0618.1	LBX1	MA0618.1	TTAATTAG	LBX1	0.000907	1.89e-06	7530	46.5	7360	43.9	1.06
209	3	MA0874.1	Arx	MA0874.1	VTBCRYTAATTARTKSW	Arx	0.000911	1.89e-06	4240	26.2	4010	24	1.09
210	40	MA0803.1	TBX15	MA0803.1	AGGTGTGA	TBX15	0.0011	2.28e-06	1010	6.23	843	5.03	1.24
211	9	MA0514.2	Sox3	MA0514.2	DNACAATGGNN	Sox3	0.00114	2.34e-06	6730	41.6	6550	39.1	1.07
212	3	MA0787.1	POU3F2	MA0787.1	WTATGCWAATKA	POU3F2	0.0012	2.45e-06	6690	41.4	6510	38.8	1.07
213	19	MA0909.3	Hoxd13	MA0909.3	NNCAATAAAW	Hoxd13	0.00127	2.58e-06	7840	48.4	7680	45.9	1.06
214	32	MA0106.3	TP53	MA0106.3	RACATGYCCGGRCATGTY	TP53	0.00137	2.77e-06	166	1.03	95	0.57	1.8
215	9	MA1561.1	SOX12	MA1561.1	ACCGAACAATV	SOX12	0.00146	2.94e-06	10500	65	10500	62.5	1.04
216	25	MA0043.3	HLF	MA0043.3	NNRTTATGCAACHN	HLF	0.00147	2.95e-06	8050	49.8	7910	47.2	1.05
217	14	MA0148.4	FOXA1	MA0148.4	WWGTAAACATNN	FOXA1	0.00153	3.06e-06	5640	34.9	5440	32.4	1.07
218	20	MA1567.2	Tbx6	MA1567.2	NRGGTGTGAANN	Tbx6	0.0017	3.39e-06	6900	42.7	6730	40.2	1.06
219	35	MA0467.2	Crx	MA0467.2	NDGGATTANN	Crx	0.00202	4.02e-06	11200	69.3	11200	67	1.04
220	27	MA0905.1	HOXC10	MA0905.1	GTCRTAAAAH	HOXC10	0.00203	4.02e-06	7980	49.4	7850	46.8	1.05
221	3	MA1498.2	HOXA7	MA1498.2	SYMATTAV	HOXA7	0.00222	4.37e-06	8990	55.6	8890	53.1	1.05
222	14	MA0047.3	FOXA2	MA0047.3	RWGTAAACANN	FOXA2	0.00234	4.59e-06	5160	31.9	4960	29.6	1.08
223	8	MA0831.3	TFE3	MA0831.3	GTCACGTGAC	TFE3	0.00239	4.65e-06	2680	16.6	2470	14.7	1.12
224	8	MA1995.1	Npas4	MA1995.1	NNTCGTGACHN	Npas4	0.0024	4.67e-06	11800	72.7	11800	70.4	1.03
225	37	MA0090.3	TEAD1	MA0090.3	NNACATTCCAGSN	TEAD1	0.00249	4.81e-06	5960	36.9	5770	34.5	1.07
226	41	MA1603.1	Dmrt1	MA1603.1	GHTACAAAGTADC	Dmrt1	0.00281	5.4e-06	10000	61.9	9960	59.5	1.04
227	15	MA1520.1	MAF	MA1520.1	NTGCTGASTCAGCAH	MAF	0.00334	6.39e-06	7780	48.1	7650	45.6	1.05
228	40	MA0805.1	TBX1	MA0805.1	AGGTGTGA	TBX1	0.00373	7.12e-06	795	4.91	654	3.9	1.26
229	16	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	0.00384	7.29e-06	1470	9.1	1300	7.73	1.18
230	8	MA1108.2	MXI1	MA1108.2	NNCACATGBN	MXI1	0.00399	7.54e-06	623	3.85	496	2.96	1.3
231	40	MA0806.1	TBX4	MA0806.1	AGGTGTGA	TBX4	0.00413	7.78e-06	1390	8.59	1220	7.26	1.18
232	3	MA0892.1	GSX1	MA0892.1	NCYMATTAVN	GSX1	0.00428	8.02e-06	10800	67	10800	64.6	1.04
233	3	MA0683.1	POU4F2	MA0683.1	RTGCATAATTAATGAG	POU4F2	0.00559	1.04e-05	2130	13.2	1940	11.6	1.14
234	42	MA1588.1	ZNF136	MA1588.1	RWATTCTTGGTTGRC	ZNF136	0.00599	1.11e-05	4880	30.2	4690	28	1.08
235	40	MA0689.1	TBX20	MA0689.1	WAGGTGTGAAR	TBX20	0.00702	1.3e-05	2240	13.9	2060	12.3	1.13
236	43	MA1953.1	FOXO1::ELF1	MA1953.1	RTMAACAGGAAGTN	FOXO1::ELF1	0.00776	1.43e-05	10200	63.3	10200	61	1.04
237	44	MA1489.1	FOXN3	MA1489.1	GTAAACAA	FOXN3	0.00841	1.54e-05	7110	44	6980	41.6	1.06
238	14	MA0480.2	Foxo1	MA0480.2	NDGTAAACANN	Foxo1	0.00884	1.61e-05	3110	19.2	2910	17.4	1.1
239	3	MA1507.1	HOXD4	MA1507.1	VTMATTAD	HOXD4	0.00968	1.76e-05	3360	20.8	3160	18.9	1.1
240	45	MA1989.1	Bcl11B	MA1989.1	NNAAACCACAARNN	Bcl11B	0.0105	1.91e-05	14600	90.4	14900	88.9	1.02
241	3	MA1504.1	HOXC4	MA1504.1	VTMATTAN	HOXC4	0.0109	1.97e-05	3400	21	3200	19.1	1.1
242	3	MA1497.1	HOXA6	MA1497.1	BGYMATTANN	HOXA6	0.0111	1.99e-05	6500	40.2	6350	37.9	1.06
243	16	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	0.0118	2.11e-05	1190	7.36	1040	6.19	1.19
244	14	MA0031.1	FOXD1	MA0031.1	GTAAACAW	FOXD1	0.0121	2.16e-05	8810	54.5	8740	52.2	1.04
15	55	MA0679.2 (ONECUT1)	MEME-1	WAAAAAWAMAWAAAW	WAAAAAWAMAWAAAW	ONECUT1	0.0125	0.000831	6200	38.3	6130	36.6	1.05
245	9	MA1962.1	POU2F1::SOX2	MA1962.1	MATTTRCATMACAATRG	POU2F1::SOX2	0.0131	2.33e-05	3770	23.3	3580	21.4	1.09
246	46	MA0698.1	ZBTB18	MA0698.1	NATCCAGATGTKB	ZBTB18	0.0132	2.33e-05	6220	38.5	6070	36.2	1.06
247	40	MA0801.1	MGA	MA0801.1	AGGTGTGA	MGA	0.0133	2.34e-05	533	3.29	422	2.52	1.31
248	19	MA0036.3	GATA2	MA0036.3	NBCTTATCTNH	GATA2	0.0136	2.38e-05	1070	6.61	923	5.51	1.2
249	3	MA0132.2	PDX1	MA0132.2	VYAATTAR	PDX1	0.0154	2.68e-05	3590	22.2	3400	20.3	1.09
250	16	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	0.0158	2.74e-05	3250	20.1	3060	18.3	1.1
251	18	MA0038.2	GFI1	MA0038.2	BMAATCACDGCA	GFI1	0.0162	2.81e-05	2780	17.2	2600	15.5	1.11
252	3	MA1471.1	BARX2	MA1471.1	NWWAAYMATTAN	BARX2	0.0167	2.88e-05	9840	60.8	9820	58.6	1.04
253	47	MA1576.1	THRB	MA1576.1	DTGACCTBACGTGACCTYA	THRB	0.0169	2.9e-05	1480	9.17	1320	7.9	1.16
254	16	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	0.0174	2.98e-05	5480	33.9	5320	31.8	1.07
255	16	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	0.0178	3.03e-05	4550	28.1	4370	26.1	1.08
256	48	MA1975.1	ZNF214	MA1975.1	VWTCATCAABGTCCT	ZNF214	0.0218	3.71e-05	11800	72.8	11900	70.8	1.03
257	3	MA0784.2	POU1F1	MA0784.2	ANCTMATTWGCATAWT	POU1F1	0.025	4.23e-05	1470	9.07	1310	7.84	1.16
258	29	MA0678.1	OLIG2	MA0678.1	AMCATATGKT	OLIG2	0.0254	4.27e-05	3340	20.6	3160	18.9	1.09
259	8	MA1994.1	Nkx2-1	MA1994.1	NVCACTTGARHNN	Nkx2-1	0.0268	4.49e-05	14600	90	14800	88.6	1.02
260	49	MA1980.1	ZNF418	MA1980.1	MDGAGGCTAAAAGCA	ZNF418	0.0272	4.55e-05	7490	46.3	7390	44.1	1.05
261	8	MA0492.1	JUND	MA0492.1	DDDRATGABGTCATN	JUND	0.0303	5.04e-05	1890	11.7	1730	10.3	1.13
262	50	MA1984.1	ZNF667	MA1984.1	TTAAGAGCTCAV	ZNF667	0.0316	5.24e-05	13600	84.1	13800	82.5	1.02
263	40	MA0800.1	EOMES	MA0800.1	RAGGTGTGAAAWN	EOMES	0.0344	5.68e-05	1600	9.92	1450	8.65	1.15
264	51	MA0002.2 (Runx1)	STREME-10	10-CAACCAGAGTG	10-CAACCAGAGTG	Runx1	0.0347	5.71e-05	9200	56.8	9160	54.7	1.04
265	9	MA1152.1	SOX15	MA1152.1	CYWTTGTTHW	SOX15	0.0368	6.03e-05	7840	48.5	7760	46.3	1.05
266	3	MA0891.1	GSC2	MA0891.1	NYTAATCCBH	GSC2	0.0391	6.39e-05	11300	70.1	11400	68.1	1.03
267	52	MA0050.3 (Irf1)	MEME-7	ADRDRNRSAVAVWGA	ADRDRNRSAVAVWGA	Irf1	0.0396	6.44e-05	6550	40.5	6430	38.4	1.06
268	3	MA0702.2	LMX1A	MA0702.2	TTAATTAM	LMX1A	0.0407	6.6e-05	2970	18.3	2800	16.7	1.1
269	1	MA0591.1	Bach1::Mafk	MA0591.1	RSSATGACTCAGCAB	Bach1::Mafk	0.0453	7.32e-05	136	0.84	82	0.49	1.71
270	9	MA0867.2	SOX4	MA0867.2	RAACAAAGRV	SOX4	0.0478	7.7e-05	11900	73.3	12000	71.3	1.03
271	53	MA0108.2	TBP	MA0108.2	STATAAAWRSVVVBN	TBP	0.0486	7.78e-05	7270	45	7180	42.8	1.05
272	54	MA1991.1	Hnf1A	MA1991.1	NBCCTTTGATSTBN	Hnf1A	0.0487	7.78e-05	5480	33.9	5340	31.9	1.06
16	56	MA1596.1 (ZNF460)	MEME-3	GGGAGGDGGAGGVDG	GGGAGGDGGAGGVDG	ZNF460	4.91	0.307	10	0.06	7	0.04	1.42
17	16	MA1961.1 (PATZ1)	MEME-2	GGSGGCGGGGSSGGG	GGSGGCGGGGSSGGG	PATZ1	16.9	0.996	363	2.24	452	2.7	0.832

ER_rat <- 1.25

DNR_242kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DNR_242kb_combo response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DNR_242kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y, TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*4), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( "DNR_24 2kb response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DNR_DAR 24 20kb data

DNR_24_20kb_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_24_20kb_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DNR_24_20kb_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_24_20kb_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DNR_24_20kb_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_24_20kb_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DNR_24_20kb_sea_all <- rbind(DNR_24_20kb_sea_disc, DNR_24_20kb_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DNR_24_20kb_combo <- DNR_24_20kb_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DNR_24_20kb_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

DNR_24_20kb_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in DNR 24h 20kb") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in DNR 24h 20kb
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA1134.1 (FOS::JUNB)	STREME-1	1-RATGASTCATY	RATGASTCATY	FOS::JUNB	1.07e-255	6.3e-256	4120	9.28	1530	3.63	2.56
2	1	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	7.89e-246	2.32e-246	5300	11.9	2340	5.53	2.16
3	1	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	7.37e-244	1.44e-244	5710	12.8	2630	6.21	2.07
4	1	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	5.01e-243	7.36e-244	4760	10.7	2000	4.72	2.27
5	1	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	5.84e-242	6.87e-243	5800	13.1	2700	6.39	2.04
6	1	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	2.96e-239	2.9e-240	5660	12.7	2620	6.19	2.06
7	1	MA0655.1 (JDP2)	MEME-2	ATGASTCA	ATGASTCA	JDP2	7.98e-237	6.71e-238	5960	13.4	2840	6.7	2
8	1	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	3.8e-229	2.8e-230	4600	10.3	1940	4.59	2.25
9	1	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	3.38e-226	2.21e-227	5920	13.3	2870	6.78	1.97
10	1	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	5.53e-226	3.25e-227	4650	10.5	1990	4.71	2.22
11	1	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	2.3e-224	1.23e-225	3810	8.58	1460	3.45	2.48
12	1	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	3.64e-220	1.79e-221	6120	13.8	3040	7.18	1.92
13	1	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	1.06e-217	4.79e-219	3700	8.33	1420	3.35	2.49
14	1	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	9.53999999999999e-213	4.01e-214	6530	14.7	3380	7.98	1.84
15	1	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	1.6e-211	6.27e-213	4130	9.29	1720	4.05	2.29
16	1	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	4.27e-211	1.57e-212	4420	9.96	1910	4.52	2.2
17	1	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	1.43e-209	4.97e-211	4220	9.5	1780	4.21	2.25
18	1	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	1.19e-206	3.88e-208	3590	8.08	1390	3.29	2.46
19	1	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	4.85e-205	1.5e-206	5900	13.3	2960	7.01	1.89
20	1	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	7.93e-204	2.33e-205	3290	7.41	1220	2.88	2.58
21	1	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	7.52e-202	2.11e-203	4050	9.11	1700	4.03	2.26
22	1	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	3.97e-198	1.06e-199	3040	6.83	1080	2.55	2.67
23	1	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	5.7e-197	1.46e-198	5380	12.1	2640	6.24	1.94
24	1	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	7.18e-186	1.76e-187	3610	8.13	1490	3.52	2.31
25	1	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	1.05e-178	2.47e-180	5340	12	2710	6.4	1.88
26	1	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	3.7e-169	8.37e-171	6080	13.7	3310	7.82	1.75
27	1	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	8.74e-169	1.9e-170	7040	15.8	4040	9.55	1.66
28	1	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	1.41e-128	2.97e-130	1910	4.3	659	1.56	2.76
29	1	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	2.98e-80	6.05e-82	10100	22.8	7430	17.6	1.3
30	1	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	2.4e-71	4.7e-73	9320	21	6840	16.2	1.3
31	1	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	1.57e-64	2.99e-66	3060	6.88	1780	4.2	1.64
32	1	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	3.63e-44	6.67e-46	3610	8.13	2390	5.66	1.44
33	2	6-ACATACACACAM	STREME-6	6-ACATACACACAM	ACATACACACAM	ACATACACACAM	1.55e-41	2.76e-43	1020	2.29	458	1.08	2.12
34	1	MA0150.2	Nfe2l2	MA0150.2	CASNATGACTCAGCA	Nfe2l2	7.34e-41	1.27e-42	14700	33	12100	28.6	1.15
35	2	4-ACACACATACA	STREME-4	4-ACACACATACA	ACACACATACA	ACACACATACA	2.47e-34	4.15e-36	1070	2.41	533	1.26	1.91
36	2	TGTGTGTGTGT	MEME-4	TGTGTGTGTGT	TGTGTGTGTGT	TGTGTGTGTGT	1.55e-31	2.53e-33	1900	4.28	1170	2.76	1.55
37	2	MA1107.2 (KLF9)	STREME-2	2-CACACACACAC	CACACACACAC	KLF9	5.05e-29	8.03e-31	1670	3.76	1010	2.39	1.57
38	3	MA1990.1 (Gli1)	STREME-8	8-CACACACCACACAYA	CACACACCACACAYA	Gli1	1.71e-28	2.65e-30	169	0.38	17	0.04	8.99
39	2	MA1155.1 (ZSCAN4)	STREME-5	5-TGCACACACACA	TGCACACACACA	ZSCAN4	1.25e-25	1.89e-27	1360	3.06	803	1.9	1.61
40	4	3-ATGTGTG	STREME-3	3-ATGTGTG	ATGTGTG	ATGTGTG	5.08e-24	7.48e-26	29600	66.6	26700	63.1	1.05
41	5	MA0707.2	MNX1	MA0707.2	VYRATTAK	MNX1	1.62e-22	2.33e-24	24100	54.2	21400	50.7	1.07
42	5	MA0904.2	HOXB5	MA0904.2	STAATTAS	HOXB5	4.47e-22	6.27e-24	24400	55	21800	51.5	1.07
43	5	MA1495.1	HOXA1	MA1495.1	STAATTAS	HOXA1	1.24e-20	1.7e-22	24100	54.2	21500	50.8	1.07
44	5	MA1519.1	LHX5	MA1519.1	STAATTAV	LHX5	3.89e-20	5.2e-22	18400	41.4	16100	38.1	1.09
45	5	MA0158.2	HOXA5	MA0158.2	GYMATTAS	HOXA5	6e-20	7.85e-22	20300	45.7	17900	42.4	1.08
46	6	MA0626.1	Npas2	MA0626.1	NSCACGTGTN	Npas2	2.66e-18	3.4e-20	18500	41.6	16300	38.5	1.08
47	1	MA0591.1	Bach1::Mafk	MA0591.1	RSSATGACTCAGCAB	Bach1::Mafk	6.06e-18	7.59e-20	6670	15	5420	12.8	1.17
48	5	MA0886.1	EMX2	MA0886.1	VBTAATTARB	EMX2	1.47e-17	1.81e-19	28500	64.2	25900	61.2	1.05
49	5	MA0705.1	Lhx8	MA0705.1	CTAATTAV	Lhx8	6.22e-16	7.47e-18	24700	55.5	22200	52.6	1.06
50	5	MA0661.1	MEOX1	MA0661.1	VSTAATTAHC	MEOX1	4.86e-15	5.72e-17	19000	42.7	16800	39.8	1.07
51	7	MA1155.1	ZSCAN4	MA1155.1	TGCACACACTGAAAA	ZSCAN4	2.91e-14	3.36e-16	1040	2.33	656	1.55	1.5
52	5	MA0912.2	HOXD3	MA0912.2	CTAATTAC	HOXD3	7.43e-14	8.41e-16	15000	33.9	13200	31.2	1.08
53	8	MA0041.2	FOXD3	MA0041.2	WAWGHAAATAAACARY	FOXD3	1.09e-13	1.21e-15	33100	74.6	30500	72.1	1.03
54	8	MA1606.1	Foxf1	MA1606.1	DWRTAAACANN	Foxf1	2.55e-13	2.75e-15	39500	88.8	36800	87.1	1.02
55	5	MA0902.2	HOXB2	MA0902.2	SYAATTAS	HOXB2	2.57e-13	2.75e-15	16000	36.1	14200	33.5	1.08
56	9	MA1115.1	POU5F1	MA1115.1	WHATGCAAATN	POU5F1	6.76e-13	7.1e-15	34200	77	31600	74.7	1.03
57	5	MA0612.2	EMX1	MA0612.2	BTAATTAS	EMX1	1.74e-12	1.79e-14	14500	32.7	12800	30.2	1.08
58	8	MA0846.1	FOXC2	MA0846.1	WAWGTAAACAWW	FOXC2	2.02e-12	2.05e-14	36600	82.4	34000	80.4	1.03
59	5	MA0910.2	HOXD8	MA0910.2	GYMATTAM	HOXD8	2.27e-12	2.27e-14	23000	51.9	20800	49.2	1.05
60	10	MA1143.1	FOSL1::JUND	MA1143.1	RTGACGTMAY	FOSL1::JUND	2.4e-12	2.35e-14	16000	36	14200	33.5	1.08
61	1	MA1639.1	MEIS1	MA1639.1	NHCATMAATCAHN	MEIS1	3.26e-12	3.14e-14	33900	76.3	31300	74	1.03
62	9	MA0792.1	POU5F1B	MA0792.1	TATGCWAAT	POU5F1B	3.4e-12	3.23e-14	35600	80.1	33000	77.9	1.03
63	5	MA0706.1	MEOX2	MA0706.1	DSTAATTAWN	MEOX2	5.85e-12	5.46e-14	25400	57.2	23100	54.6	1.05
64	5	MA0027.2	EN1	MA0027.2	SYAATTAV	EN1	6.26e-12	5.75e-14	32400	72.8	29800	70.5	1.03
65	11	MA0502.2 (NFYB)	STREME-9	9-CRGCCAATGG	CRGCCAATGG	NFYB	8.75e-12	7.91e-14	286	0.64	123	0.29	2.2
66	13	MA0766.2	GATA5	MA0766.2	SWGATAASRN	GATA5	8.88e-12	7.91e-14	7680	17.3	6500	15.4	1.13
67	5	MA1502.1	HOXB8	MA1502.1	GYMATTAM	HOXB8	9.3e-12	8.16e-14	22800	51.4	20700	48.8	1.05
68	8	MA0845.1	FOXB1	MA0845.1	WATGTAAATAT	FOXB1	1.31e-11	1.14e-13	34200	77	31600	74.8	1.03
69	6	MA0093.3	USF1	MA0093.3	NDGTCATGTGACHN	USF1	1.33e-11	1.14e-13	35700	80.4	33100	78.3	1.03
70	12	MA0676.1	Nr2e1	MA0676.1	AAAAGTCAA	Nr2e1	1.66e-11	1.39e-13	12600	28.3	11000	26	1.09
71	13	MA0036.3 (GATA2)	STREME-10	10-WGATAAG	10-WGATAAG	GATA2	2.08e-11	1.73e-13	28900	65	26500	62.5	1.04
72	11	MA0502.2	NFYB	MA0502.2	CYCATTGGCCVV	NFYB	2.59e-11	2.12e-13	2650	5.97	2040	4.81	1.24
73	14	MA0106.3	TP53	MA0106.3	RACATGYCCGGRCATGTY	TP53	2.7e-11	2.18e-13	5100	11.5	4190	9.9	1.16
74	5	MA1530.1	NKX6-3	MA1530.1	VYCATTAWW	NKX6-3	5.68e-11	4.52e-13	23700	53.2	21500	50.7	1.05
75	9	MA0142.1	Pou5f1::Sox2	MA0142.1	CWTTGTYATGCAAAT	Pou5f1::Sox2	6.16e-11	4.83e-13	31500	70.9	29000	68.6	1.03
76	15	MA0148.4	FOXA1	MA0148.4	WWGTAAACATNN	FOXA1	6.52e-11	5.05e-13	36800	82.8	34200	80.8	1.02
77	1	MA1640.1	MEIS2	MA1640.1	NNATGATTTATGDNH	MEIS2	7.83e-11	5.98e-13	35500	79.8	32900	77.8	1.03
78	9	MA0786.1	POU3F1	MA0786.1	WTATGCWAATKW	POU3F1	1.16e-10	8.72e-13	34200	77	31700	74.8	1.03
79	1	MA1113.2	PBX2	MA1113.2	NHCATAAATCAHN	PBX2	1.64e-10	1.22e-12	30300	68.2	27900	65.9	1.04
80	9	MA0785.1	POU2F1	MA0785.1	AWTATGCWAATK	POU2F1	2.42e-10	1.78e-12	32100	72.3	29700	70.1	1.03
81	15	MA0848.1	FOXO4	MA0848.1	GTAAACA	FOXO4	2.62e-10	1.9e-12	36200	81.5	33600	79.5	1.02
82	9	MA0789.1	POU3F4	MA0789.1	TATGCWAAT	POU3F4	2.89e-10	2.07e-12	29200	65.7	26800	63.4	1.04
83	8	MA1683.1	FOXA3	MA1683.1	DWGTAAACANN	FOXA3	3.57e-10	2.53e-12	34400	77.3	31800	75.3	1.03
84	5	MA0879.2	DLX1	MA0879.2	VYAATTAN	DLX1	3.78e-10	2.65e-12	34000	76.4	31400	74.3	1.03
85	5	MA1505.1	HOXC8	MA1505.1	KTAATTAM	HOXC8	6.16e-10	4.26e-12	33700	75.9	31200	73.8	1.03
86	15	MA0033.2	FOXL1	MA0033.2	RTAAACA	FOXL1	9.73e-10	6.66e-12	35800	80.4	33200	78.5	1.02
87	9	MA0787.1	POU3F2	MA0787.1	WTATGCWAATKA	POU3F2	9.93e-10	6.72e-12	29500	66.5	27200	64.2	1.04
88	5	MA0900.2	HOXA2	MA0900.2	STAATTAS	HOXA2	1.14e-09	7.6e-12	16400	36.8	14600	34.6	1.07
89	5	MA0675.1	NKX6-2	MA0675.1	NYMATTAA	NKX6-2	1.5e-09	9.93e-12	32300	72.7	29900	70.6	1.03
90	6	MA1108.2	MXI1	MA1108.2	NNCACATGBN	MXI1	1.55e-09	1.01e-11	19300	43.4	17400	41.1	1.06
91	8	MA0481.3	FOXP1	MA0481.3	NDGTAAACANH	FOXP1	1.63e-09	1.06e-11	38100	85.8	35600	84.1	1.02
92	8	MA0047.3	FOXA2	MA0047.3	RWGTAAACANN	FOXA2	2.26e-09	1.45e-11	39400	88.6	36900	87.1	1.02
93	23	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	4.81e-09	3.04e-11	35500	79.8	33000	78	1.02
94	5	MA0701.2	LHX9	MA0701.2	CYAATTAR	LHX9	5.96e-09	3.73e-11	13200	29.8	11700	27.7	1.08
95	8	MA1103.2	FOXK2	MA1103.2	DDGTAAACANN	FOXK2	6.94e-09	4.3e-11	41000	92.3	38500	91	1.01
96	5	MA0644.2	ESX1	MA0644.2	YYAATTAN	ESX1	7.47e-09	4.58e-11	26900	60.6	24700	58.3	1.04
97	9	MA0627.2	POU2F3	MA0627.2	NWTATGCAAATNH	POU2F3	1.62e-08	9.8e-11	31900	71.7	29500	69.7	1.03
98	16	MA1479.1	DMRTC2	MA1479.1	AATTGMTACATT	DMRTC2	2e-08	1.2e-10	34600	77.9	32200	76	1.02
99	5	MA0708.2	MSX2	MA0708.2	SCAATTAV	MSX2	2.37e-08	1.41e-10	30900	69.6	28600	67.6	1.03
100	9	MA0788.1	POU3F3	MA0788.1	WWTATGCWAATTW	POU3F3	2.56e-08	1.5e-10	31300	70.4	28900	68.4	1.03
101	8	MA1978.1	ZNF354A	MA1978.1	HWAADWATAAATGRAYWAWTT	ZNF354A	2.63e-08	1.53e-10	32700	73.5	30300	71.5	1.03
102	5	MA1549.1	POU6F1	MA1549.1	RTAATGAGVN	POU6F1	4.01e-08	2.31e-10	25800	58.2	23700	56	1.04
103	5	MA0666.2	MSX1	MA0666.2	SCAATTAR	MSX1	4.56e-08	2.61e-10	28700	64.5	26400	62.4	1.03
104	17	MA1120.1	SOX13	MA1120.1	DVACAATGGNN	SOX13	4.92e-08	2.78e-10	38400	86.3	35900	84.8	1.02
105	5	MA0882.1	DLX6	MA0882.1	VYAATTAN	DLX6	5.95e-08	3.34e-10	38400	86.3	35900	84.8	1.02
106	18	MA0791.1	POU4F3	MA0791.1	RTGMATWATTAATGAR	POU4F3	6.01e-08	3.34e-10	26400	59.4	24200	57.3	1.04
107	5	MA0718.1	RAX	MA0718.1	RYYAATTARH	RAX	6.68e-08	3.67e-10	36200	81.4	33700	79.7	1.02
108	23	MA0117.2	Mafb	MA0117.2	AWWNTGCTGACD	Mafb	9.29e-08	5.06e-10	34500	77.5	32000	75.7	1.02
109	23	MA0842.2	NRL	MA0842.2	AAWWNTGCTGACG	NRL	9.86e-08	5.32e-10	6930	15.6	5950	14	1.11
110	10	MA0018.4	CREB1	MA0018.4	NNRTGATGTCAYN	CREB1	1.04e-07	5.59e-10	19200	43.3	17400	41.2	1.05
111	5	MA0887.1	EVX1	MA0887.1	VVTAATTABS	EVX1	1.48e-07	7.85e-10	30000	67.6	27700	65.6	1.03
112	5	MA0709.1	Msx3	MA0709.1	SCAATTAN	Msx3	1.82e-07	9.58e-10	23600	53	21500	50.9	1.04
113	5	MA0722.1	VAX1	MA0722.1	YTAATTAH	VAX1	2.48e-07	1.29e-09	25100	56.6	23100	54.5	1.04
114	5	MA0654.1	ISX	MA0654.1	YYAATTAR	ISX	3.63e-07	1.87e-09	23900	53.9	21900	51.8	1.04
115	5	MA0880.1	Dlx3	MA0880.1	NYAATTAN	Dlx3	4.06e-07	2.08e-09	24900	56.1	22900	54	1.04
116	5	MA0710.1	NOTO	MA0710.1	NYTAATTAVN	NOTO	6.04e-07	3.06e-09	24900	56.1	22900	54.1	1.04
117	19	MA0611.2	Dux	MA0611.2	NTGATTBAATCAVWNN	Dux	7.78e-07	3.91e-09	13600	30.6	12200	28.7	1.06
118	5	MA1476.2	Dlx5	MA1476.2	NDGCAATTAGNN	Dlx5	8.72e-07	4.35e-09	37600	84.6	35200	83.1	1.02
119	20	MA0797.1	TGIF2	MA0797.1	TGACAGSTGTCA	TGIF2	8.86e-07	4.38e-09	13600	30.7	12200	28.8	1.06
120	21	MA0090.3	TEAD1	MA0090.3	NNACATTCCAGSN	TEAD1	1.05e-06	5.15e-09	33000	74.2	30600	72.4	1.02
121	5	MA0704.1	Lhx4	MA0704.1	YTAATTAR	Lhx4	1.21e-06	5.87e-09	37200	83.6	34700	82.1	1.02
122	5	MA0700.2	LHX2	MA0700.2	DDCCAATTADN	LHX2	1.38e-06	6.62e-09	33900	76.2	31500	74.5	1.02
123	15	MA0042.2	FOXI1	MA0042.2	GTAAACA	FOXI1	1.38e-06	6.62e-09	35200	79.2	32800	77.6	1.02
124	22	MA1124.1	ZNF24	MA1124.1	CATTCATTCATTC	ZNF24	2.21e-06	1.05e-08	22700	51.2	20800	49.2	1.04
125	5	MA0885.2	Dlx2	MA0885.2	NDGCAATTAGNN	Dlx2	3.34e-06	1.57e-08	36800	82.9	34400	81.4	1.02
126	5	MA0658.1	LHX6	MA0658.1	RCTAATTARY	LHX6	3.35e-06	1.57e-08	18700	42.2	17000	40.2	1.05
127	5	MA0889.1	GBX1	MA0889.1	VCYAATTASY	GBX1	4.57e-06	2.12e-08	18400	41.3	16700	39.4	1.05
128	23	MA0495.3 (MAFF)	STREME-7	7-CTGTCAGCACT	CTGTCAGCACT	MAFF	4.65e-06	2.14e-08	1140	2.57	843	1.99	1.29
129	24	MA1114.1	PBX3	MA1114.1	NNNTGAGTGACAGGBNN	PBX3	4.69e-06	2.14e-08	14500	32.6	13000	30.8	1.06
130	5	MA0793.1	POU6F2	MA0793.1	ASCTMATTAW	POU6F2	4.88e-06	2.21e-08	23800	53.6	21900	51.7	1.04
131	5	MA1960.1	MGA::EVX1	MA1960.1	RGGTGWTAATKD	MGA::EVX1	4.95e-06	2.22e-08	30100	67.6	27800	65.8	1.03
132	8	MA0032.2	FOXC1	MA0032.2	WAWGTAAAYAW	FOXC1	6.47e-06	2.88e-08	27300	61.5	25200	59.6	1.03
133	18	MA0790.1	POU4F1	MA0790.1	ATGMATAATTAATG	POU4F1	6.66e-06	2.95e-08	27800	62.5	25700	60.6	1.03
134	8	MA0480.2	Foxo1	MA0480.2	NDGTAAACANN	Foxo1	7e-06	3.07e-08	40300	90.7	37900	89.5	1.01
135	25	MA0755.1	CUX2	MA0755.1	TRATCGATAW	CUX2	7.1e-06	3.09e-08	24000	53.9	22000	52	1.04
136	5	MA0890.1	GBX2	MA0890.1	RSYAATTARN	GBX2	7.27e-06	3.15e-08	23800	53.5	21800	51.6	1.04
137	14	MA0861.1	TP73	MA0861.1	DRCATGTCNNRACAYGYM	TP73	7.8e-06	3.35e-08	7720	17.4	6740	15.9	1.09
138	20	MA0774.1	MEIS2	MA0774.1	TTGACAGS	MEIS2	7.9e-06	3.37e-08	4620	10.4	3920	9.27	1.12
139	6	MA1618.1	Ptf1a	MA1618.1	NNACAGATGTTNN	Ptf1a	9.02e-06	3.82e-08	36900	83.1	34600	81.7	1.02
140	6	MA1570.1	TFAP4	MA1570.1	AHCATRTGDT	TFAP4	9.34e-06	3.92e-08	15400	34.6	13900	32.8	1.05
141	5	MA0488.1	JUN	MA0488.1	DDRATGATGTCAT	JUN	1.01e-05	4.21e-08	7520	16.9	6570	15.5	1.09
142	8	MA1607.1	Foxl2	MA1607.1	DDWATGTAAACANN	Foxl2	1.06e-05	4.4e-08	37700	84.8	35300	83.4	1.02
143	38	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	1.1e-05	4.52e-08	1990	4.48	1580	3.73	1.2
144	26	MA0805.1	TBX1	MA0805.1	AGGTGTGA	TBX1	1.15e-05	4.7e-08	2260	5.09	1810	4.29	1.19
145	5	MA0723.2	VAX2	MA0723.2	BYAATTAV	VAX2	1.25e-05	5.08e-08	38500	86.7	36100	85.4	1.02
146	6	MA0871.2	TFEC	MA0871.2	NVCACGTGACN	TFEC	1.61e-05	6.5e-08	10600	23.9	9430	22.3	1.07
147	5	MA0075.3	PRRX2	MA0075.3	CTAATTAN	PRRX2	2.05e-05	8.2e-08	17600	39.7	16000	37.9	1.05
148	24	MA0063.2	NKX2-5	MA0063.2	NNCACTCAANN	NKX2-5	2.18e-05	8.68e-08	41000	92.2	38600	91.2	1.01
149	6	MA0461.2	Atoh1	MA0461.2	RMCATATGBY	Atoh1	4.03e-05	1.59e-07	30900	69.5	28700	67.8	1.02
150	17	MA0514.2	Sox3	MA0514.2	DNACAATGGNN	Sox3	4.17e-05	1.64e-07	40100	90.2	37700	89	1.01
151	5	MA0699.1	LBX2	MA0699.1	NCYAATTARN	LBX2	4.48e-05	1.74e-07	21300	48	19500	46.2	1.04
152	14	MA0525.2	TP63	MA0525.2	RACATGTYGKGACATGTC	TP63	4.56e-05	1.76e-07	404	0.91	252	0.6	1.52
153	27	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	4.8e-05	1.85e-07	39400	88.8	37100	87.6	1.01
154	5	MA1480.1	DPRX	MA1480.1	AGATAATCCN	DPRX	5.72e-05	2.18e-07	35500	79.8	33200	78.4	1.02
155	8	MA0851.1	Foxj3	MA0851.1	NDAADGTAAACAAANNM	Foxj3	6.97e-05	2.65e-07	24900	56	22900	54.2	1.03
156	5	MA0881.1	Dlx4	MA0881.1	VYAATTAN	Dlx4	8.13e-05	3.07e-07	38400	86.4	36000	85.1	1.01
157	5	MA1499.1	HOXB4	MA1499.1	RTMATTAR	HOXB4	8.71e-05	3.26e-07	17100	38.5	15600	36.8	1.05
158	24	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	9.04e-05	3.36e-07	9480	21.3	8420	19.9	1.07
159	5	MA1481.1	DRGX	MA1481.1	YYAATTAN	DRGX	0.000114	4.22e-07	34600	78	32400	76.5	1.02
160	5	MA0720.1	Shox2	MA0720.1	YYAATTAR	Shox2	0.000129	4.73e-07	16600	37.3	15100	35.6	1.05
161	5	MA1496.1	HOXA4	MA1496.1	RTMATTAV	HOXA4	0.000157	5.74e-07	27400	61.7	25400	60	1.03
162	13	MA0036.3	GATA2	MA0036.3	NBCTTATCTNH	GATA2	0.000198	7.19e-07	24100	54.2	22200	52.5	1.03
163	5	MA1500.1	HOXB6	MA1500.1	BTAATKRC	HOXB6	0.000202	7.3e-07	29400	66.2	27300	64.6	1.03
164	28	MA0596.1	SREBF2	MA0596.1	RTGGGGTGAY	SREBF2	0.00033	1.18e-06	5520	12.4	4800	11.3	1.1
165	15	MA0613.1	FOXG1	MA0613.1	RTAAACAW	FOXG1	0.000345	1.23e-06	18400	41.5	16900	39.9	1.04
166	17	MA0143.4	SOX2	MA0143.4	DNACAATGGNN	SOX2	0.000355	1.26e-06	41600	93.5	39200	92.7	1.01
167	17	MA1563.2	SOX18	MA1563.2	AACAATDV	SOX18	0.00038	1.34e-06	31900	71.8	29800	70.3	1.02
168	5	MA0680.2	Pax7	MA0680.2	DWTAATCAATTAWNH	Pax7	0.000392	1.37e-06	26500	59.6	24500	57.9	1.03
169	5	MA0888.1	EVX2	MA0888.1	VVTAATTAVB	EVX2	0.000392	1.37e-06	29800	67.1	27700	65.5	1.02
170	23	MA0495.3	MAFF	MA0495.3	DWGTCAGCATTTTWHN	MAFF	0.000413	1.43e-06	37000	83.4	34700	82.1	1.02
171	5	MA0892.1	GSX1	MA0892.1	NCYMATTAVN	GSX1	0.000427	1.47e-06	43200	97.2	40900	96.6	1.01
172	27	MA0035.4	GATA1	MA0035.4	NHCTAATCTDH	GATA1	0.000514	1.76e-06	19800	44.6	18200	42.9	1.04
173	5	MA0716.1	PRRX1	MA0716.1	YYAATTAR	PRRX1	0.000542	1.84e-06	37900	85.3	35600	84.1	1.01
174	17	MA0077.1	SOX9	MA0077.1	CYATTGTTY	SOX9	0.00069	2.33e-06	41100	92.5	38800	91.6	1.01
175	17	MA1562.1	SOX14	MA1562.1	CCGAACAATG	SOX14	0.000693	2.33e-06	25200	56.8	23300	55.2	1.03
176	26	MA0803.1	TBX15	MA0803.1	AGGTGTGA	TBX15	0.000781	2.61e-06	29600	66.6	27500	65.1	1.02
177	5	MA0628.1	POU6F1	MA0628.1	AYTAATTART	POU6F1	0.000872	2.9e-06	27700	62.4	25700	60.8	1.03
178	20	MA0691.1	TFAP4	MA0691.1	AWCAGCTGWT	TFAP4	0.00109	3.61e-06	4140	9.3	3550	8.39	1.11
179	5	MA0630.1	SHOX	MA0630.1	HTAATTRR	SHOX	0.00119	3.9e-06	40800	91.8	38500	90.9	1.01
180	29	MA0073.1	RREB1	MA0073.1	CCCCMAAMCAMCCMCMMMCV	RREB1	0.00135	4.41e-06	856	1.93	640	1.51	1.27
181	1	MA0070.1	PBX1	MA0070.1	HCATCAATCAAW	PBX1	0.00162	5.27e-06	15700	35.2	14300	33.7	1.04
182	8	MA0897.1	Hmx2	MA0897.1	ASAAGCAATTAAHVVRT	Hmx2	0.0019	6.14e-06	24100	54.2	22300	52.6	1.03
183	30	MA1573.2	Thap11	MA1573.2	ACTACAABTCCCAG	Thap11	0.0024	7.72e-06	140	0.32	69	0.16	1.92
184	8	MA0157.3	Foxo3	MA0157.3	NDGTAAACARNN	Foxo3	0.00291	9.32e-06	42200	95.1	39900	94.4	1.01
185	31	MA0698.1	ZBTB18	MA0698.1	NATCCAGATGTKB	ZBTB18	0.00339	1.08e-05	10500	23.6	9430	22.3	1.06
186	18	MA0153.2	HNF1B	MA0153.2	GTTAATNATTAAY	HNF1B	0.00369	1.17e-05	17400	39.2	15900	37.7	1.04
187	15	MA0031.1	FOXD1	MA0031.1	GTAAACAW	FOXD1	0.00389	1.22e-05	28800	64.9	26800	63.4	1.02
188	17	MA1152.1	SOX15	MA1152.1	CYWTTGTTHW	SOX15	0.00393	1.23e-05	36400	81.8	34100	80.7	1.01
189	24	MA1645.1	NKX2-2	MA1645.1	NNNCCACTCAANNN	NKX2-2	0.00434	1.35e-05	7120	16	6320	14.9	1.07
190	31	MA0818.2	BHLHE22	MA0818.2	AMCATATGKY	BHLHE22	0.00443	1.37e-05	9680	21.8	8690	20.6	1.06
13	34	MA0682.2 (PITX1)	MEME-3	GCCTGTAATCCCAGC	GCCTGTAATCCCAGC	PITX1	0.00449	0.000345	1360	3.06	1130	2.66	1.15
191	18	MA0046.2	HNF1A	MA0046.2	DRTTAATNATTAACN	HNF1A	0.00527	1.62e-05	18400	41.4	16900	40	1.04
192	5	MA1608.1	Isl1	MA1608.1	NNCCATTAGNN	Isl1	0.00606	1.86e-05	40700	91.6	38400	90.8	1.01
193	32	MA1974.1	ZNF211	MA1974.1	HWYATATACCAYRYW	ZNF211	0.00653	1.99e-05	11200	25.2	10100	24	1.05
194	13	MA1104.2	GATA6	MA1104.2	HWWTCTTATCTNH	GATA6	0.00671	2.04e-05	21900	49.2	20200	47.7	1.03
195	15	MA0849.1	FOXO6	MA0849.1	GTAAACA	FOXO6	0.00813	2.45e-05	24400	54.9	22600	53.4	1.03
196	28	MA0595.1	SREBF1	MA0595.1	VTCACCCCAY	SREBF1	0.00886	2.66e-05	2580	5.81	2180	5.15	1.13
197	6	MA0004.1	Arnt	MA0004.1	CACGTG	Arnt	0.00929	2.78e-05	752	1.69	566	1.34	1.26
198	33	MA0052.4	MEF2A	MA0052.4	DDCTAAAAATAGMHH	MEF2A	0.0142	4.2e-05	33800	76	31600	74.8	1.02
199	26	MA0689.1	TBX20	MA0689.1	WAGGTGTGAAR	TBX20	0.0142	4.21e-05	6840	15.4	6080	14.4	1.07
200	20	MA1572.1	TGIF2LY	MA1572.1	TGACAGCTGTCA	TGIF2LY	0.0145	4.27e-05	36200	81.6	34000	80.5	1.01
201	5	MA0713.1	PHOX2A	MA0713.1	TAATYYAATTA	PHOX2A	0.0174	5.09e-05	28200	63.4	26200	62	1.02
202	5	MA0914.1	ISL2	MA0914.1	GCAMTTAR	ISL2	0.0199	5.81e-05	30700	69.1	28700	67.8	1.02
203	26	MA1567.2	Tbx6	MA1567.2	NRGGTGTGAANN	Tbx6	0.0203	5.89e-05	5620	12.7	4970	11.8	1.08
204	5	MA0674.1	NKX6-1	MA0674.1	NTMATTAA	NKX6-1	0.0224	6.45e-05	29000	65.3	27100	64	1.02
205	15	MA0850.1	FOXP3	MA0850.1	RTAAACA	FOXP3	0.0245	7.03e-05	30100	67.8	28100	66.5	1.02
206	27	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	0.0248	7.07e-05	39800	89.5	37500	88.6	1.01
207	9	MA0025.2	NFIL3	MA0025.2	NRTTATGYAATNN	NFIL3	0.0252	7.16e-05	18100	40.8	16700	39.5	1.03
208	26	MA0800.1	EOMES	MA0800.1	RAGGTGTGAAAWN	EOMES	0.0298	8.43e-05	37500	84.3	35200	83.3	1.01
209	26	MA0802.1	TBR1	MA0802.1	AGGTGTGAAA	TBR1	0.0323	9.1e-05	38000	85.5	35800	84.5	1.01
210	5	MA0642.2	EN2	MA0642.2	VSYAATTA	EN2	0.0422	0.000118	29400	66.2	27500	65	1.02
14	35	MA1973.1 (ZKSCAN3)	MEME-6	TGCCCAGGCTG	TGCCCAGGCTG	ZKSCAN3	2.1	0.15	532	1.2	470	1.11	1.08
15	36	MA0471.2 (E2F6)	MEME-7	DGAGGARGGAR	DGAGGARGGAR	E2F6	3.33	0.222	14000	31.4	13200	31.2	1.01
16	37	MA1125.1 (ZNF384)	MEME-1	AAAAAAAAAAAADWA	AAAAAAAAAAAADWA	ZNF384	3.75	0.235	1610	3.62	1490	3.52	1.03
17	38	MA1961.1 (PATZ1)	MEME-5	GGGRGGCGGRGGCGG	GGGRGGCGGRGGCGG	PATZ1	17	1	9820	22.1	10400	24.5	0.902

ER_rat <- 1.25

DNR_24_20kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DNR_24_20kb_combo response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DNR_24_20kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=7) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*9), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./9,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DNR_24_20kb_combo response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

MTX

MTX_DAR_3hr data

MTX_DAR_3hr_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_3_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
MTX_DAR_3hr_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_3_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
MTX_DAR_3hr_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_3_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
MTX_DAR_3hr_all <- rbind(MTX_DAR_3hr_sea_disc, MTX_DAR_3hr_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

MTX_DAR_3hr_combo <- MTX_DAR_3hr_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., MTX_DAR_3hr_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ NA_character_
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="MTX_DAR_3hr")

MTX_DAR_3hr_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs in 3 hour MTX-DAR v 3 hour non-MTX DAR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs in 3 hour MTX-DAR v 3 hour non-MTX DAR
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	3.29e-13	2.66e-13	204	28.2	22500	16.2	1.75	MTX_DAR_3hr
2	2	MA1513.1 (KLF15)	STREME-1	1-GCGGGCC	GCGGGCC	KLF15	2.67e-12	1.08e-12	303	41.8	39300	28.2	1.49	MTX_DAR_3hr
3	3	MA1650.1 (ZBTB14)	STREME-3	3-CCGCGCBCCCCSS	CCGCGCBCCCCSS	ZBTB14	8.67e-11	2.34e-11	83	11.5	6460	4.64	2.5	MTX_DAR_3hr
4	4	MA1650.1 (ZBTB14)	STREME-6	6-CCGCGMA	CCGCGMA	ZBTB14	1.49e-10	2.83e-11	309	42.7	41500	29.8	1.43	MTX_DAR_3hr
5	5	2-CCGGCGCK	STREME-2	2-CCGGCGCK	CCGGCGCK	CCGGCGCK	1.9e-10	2.83e-11	119	16.4	11300	8.1	2.04	MTX_DAR_3hr
6	1	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	2.1e-10	2.83e-11	423	58.4	62600	44.9	1.3	MTX_DAR_3hr
7	6	MA1653.1 (ZNF148)	STREME-4	4-CTMCCS	CTMCCS	ZNF148	2.8e-10	3.24e-11	529	73.1	83900	60.2	1.21	MTX_DAR_3hr
8	3	MA1961.1 (PATZ1)	MEME-2	CSCSCCCCKSCSCGS	CSCSCCCCKSCSCGS	PATZ1	9.69e-10	9.82e-11	170	23.5	19100	13.7	1.72	MTX_DAR_3hr
9	1	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	1.69e-09	1.52e-10	385	53.2	56100	40.3	1.32	MTX_DAR_3hr
10	1	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	3.27e-09	2.65e-10	363	50.1	52300	37.5	1.34	MTX_DAR_3hr
11	7	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	4.18e-09	3.08e-10	392	54.1	57700	41.5	1.31	MTX_DAR_3hr
12	1	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	3.43e-08	2.32e-09	116	16	11800	8.48	1.9	MTX_DAR_3hr
13	1	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	9.28e-08	5.78e-09	125	17.3	13300	9.56	1.82	MTX_DAR_3hr
14	1	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	1.12e-07	6.49e-09	429	59.2	66100	47.4	1.25	MTX_DAR_3hr
15	1	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	1.63e-07	8.83e-09	175	24.2	21100	15.2	1.6	MTX_DAR_3hr
16	8	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	3.4e-07	1.7e-08	128	17.7	14100	10.1	1.76	MTX_DAR_3hr
17	7	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	3.58e-07	1.7e-08	425	58.7	65800	47.2	1.24	MTX_DAR_3hr
18	1	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	4.1e-07	1.84e-08	330	45.6	48000	34.5	1.32	MTX_DAR_3hr
19	9	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	5.68e-07	2.42e-08	399	55.1	61000	43.8	1.26	MTX_DAR_3hr
20	1	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	9.02e-07	3.65e-08	311	43	44900	32.2	1.34	MTX_DAR_3hr
21	10	MA0750.2	ZBTB7A	MA0750.2	NVCCGGAAGTGSV	ZBTB7A	1.44e-06	5.57e-08	439	60.6	69100	49.6	1.22	MTX_DAR_3hr
22	1	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	1.52e-06	5.6e-08	338	46.7	50000	35.9	1.3	MTX_DAR_3hr
23	3	MA1961.1 (PATZ1)	STREME-5	5-CGCCCGCGSCGCCSG	CGCCCGCGSCGCCSG	PATZ1	1.72e-06	6.06e-08	24	3.31	1010	0.73	4.74	MTX_DAR_3hr
24	9	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	1.99e-06	6.72e-08	111	15.3	11900	8.56	1.8	MTX_DAR_3hr
25	1	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	2.08e-06	6.73e-08	308	42.5	44700	32.1	1.33	MTX_DAR_3hr
26	1	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	2.48e-06	7.69e-08	254	35.1	35200	25.2	1.39	MTX_DAR_3hr
27	11	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	2.56e-06	7.69e-08	93	12.8	9380	6.74	1.92	MTX_DAR_3hr
28	3	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	2.77e-06	8.03e-08	270	37.3	38000	27.3	1.37	MTX_DAR_3hr
29	1	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	4.58e-06	1.28e-07	277	38.3	39400	28.3	1.35	MTX_DAR_3hr
30	12	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	5.55e-06	1.5e-07	130	18	15000	10.8	1.67	MTX_DAR_3hr
31	7	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	5.89e-06	1.54e-07	248	34.2	34400	24.7	1.39	MTX_DAR_3hr
32	13	MA1985.1	ZNF669	MA1985.1	GGGGYGAYGACCRCT	ZNF669	1.1e-05	2.78e-07	325	44.9	48400	34.8	1.29	MTX_DAR_3hr
33	14	MA1710.1	ZNF257	MA1710.1	VDGAGGCRAGRG	ZNF257	1.61e-05	3.94e-07	501	69.2	82500	59.2	1.17	MTX_DAR_3hr
34	15	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	1.85e-05	4.41e-07	445	61.5	71400	51.2	1.2	MTX_DAR_3hr
35	16	MA1982.1	ZNF574	MA1982.1	VGSCTAGAGMGGCCS	ZNF574	8.19e-05	1.9e-06	496	68.5	82200	59	1.16	MTX_DAR_3hr
36	1	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	8.82e-05	1.98e-06	272	37.6	39700	28.5	1.32	MTX_DAR_3hr
37	7	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	9.77e-05	2.14e-06	164	22.6	21300	15.3	1.49	MTX_DAR_3hr
38	17	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	0.000119	2.53e-06	187	25.8	25100	18	1.44	MTX_DAR_3hr
39	12	MA0522.3	TCF3	MA0522.3	NVCACCTGCNN	TCF3	0.000129	2.64e-06	348	48.1	53800	38.6	1.25	MTX_DAR_3hr
40	18	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	0.00013	2.64e-06	129	17.8	15700	11.3	1.59	MTX_DAR_3hr
41	19	MA0872.1	TFAP2A	MA0872.1	TGCCCYSRGGGCA	TFAP2A	0.000147	2.91e-06	219	30.2	30700	22	1.38	MTX_DAR_3hr
42	19	MA0815.1	TFAP2C	MA0815.1	TGCCCYSRGGGCA	TFAP2C	0.000174	3.36e-06	192	26.5	26100	18.8	1.42	MTX_DAR_3hr
43	20	MA0024.3	E2F1	MA0024.3	TTTGGCGCCAAA	E2F1	0.000193	3.64e-06	179	24.7	24000	17.2	1.44	MTX_DAR_3hr
44	21	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	0.000221	4.06e-06	329	45.4	50500	36.2	1.26	MTX_DAR_3hr
45	20	MA0470.2	E2F4	MA0470.2	TTTTGGCGCCAWWW	E2F4	0.000247	4.4e-06	116	16	13900	9.96	1.62	MTX_DAR_3hr
46	12	MA1648.1	TCF12	MA1648.1	NNCACCTGCNN	TCF12	0.00025	4.4e-06	501	69.2	83800	60.2	1.15	MTX_DAR_3hr
47	7	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	0.000302	5.2e-06	282	39	42100	30.2	1.29	MTX_DAR_3hr
48	9	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	0.000314	5.3e-06	225	31.1	32000	23	1.36	MTX_DAR_3hr
49	22	MA1584.1	ZIC5	MA1584.1	VGACCCCCCGCTGHGM	ZIC5	0.000323	5.35e-06	166	22.9	22000	15.8	1.46	MTX_DAR_3hr
50	23	MA1987.1	ZNF701	MA1987.1	GAGCACYAARGGGGGRADDDD	ZNF701	0.000371	6e-06	513	70.9	86400	62	1.14	MTX_DAR_3hr
51	24	MA1972.1	ZFP14	MA1972.1	GGAGGCHCHGGARBG	ZFP14	0.000719	1.14e-05	539	74.4	92100	66.1	1.13	MTX_DAR_3hr
52	19	MA0813.1	TFAP2B	MA0813.1	TGCCCYBRGGGCA	TFAP2B	0.000729	1.14e-05	188	26	26000	18.7	1.4	MTX_DAR_3hr
53	10	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	0.000896	1.37e-05	386	53.3	61900	44.4	1.2	MTX_DAR_3hr
54	10	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	0.00097	1.46e-05	400	55.2	64600	46.4	1.19	MTX_DAR_3hr
55	9	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	0.00132	1.94e-05	302	41.7	46400	33.3	1.25	MTX_DAR_3hr
56	1	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	0.00173	2.5e-05	281	38.8	42700	30.7	1.27	MTX_DAR_3hr
57	10	MA1966.1	TFAP4::ETV1	MA1966.1	RSCGGAAGCAGSTGKN	TFAP4::ETV1	0.00206	2.92e-05	114	15.8	14200	10.2	1.56	MTX_DAR_3hr
58	1	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	0.00215	3e-05	587	81.1	103000	73.8	1.1	MTX_DAR_3hr
59	23	MA0528.2	ZNF263	MA0528.2	VNGGGGAGGASG	ZNF263	0.0029	3.98e-05	471	65.1	79100	56.8	1.15	MTX_DAR_3hr
60	18	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	0.00324	4.38e-05	270	37.3	41000	29.5	1.27	MTX_DAR_3hr
61	25	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	0.0041	5.45e-05	364	50.3	58500	42	1.2	MTX_DAR_3hr
62	1	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	0.00469	6.13e-05	133	18.4	17500	12.6	1.47	MTX_DAR_3hr
63	26	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	0.00482	6.2e-05	505	69.8	86200	61.9	1.13	MTX_DAR_3hr
64	1	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	0.00495	6.27e-05	134	18.5	17700	12.7	1.47	MTX_DAR_3hr
65	25	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	0.00672	8.25e-05	356	49.2	57300	41.1	1.2	MTX_DAR_3hr
66	20	MA1727.1	ZNF417	MA1727.1	VRBVNTGGGCGCCAM	ZNF417	0.00672	8.25e-05	314	43.4	49400	35.5	1.22	MTX_DAR_3hr
67	20	MA0864.2	E2F2	MA0864.2	RWTTTGGCGCCAWWWY	E2F2	0.00701	8.48e-05	212	29.3	31100	22.3	1.32	MTX_DAR_3hr
68	12	MA1631.1	ASCL1	MA1631.1	NNGCACCTGCYNB	ASCL1	0.00744	8.86e-05	602	83.2	107000	76.5	1.09	MTX_DAR_3hr
69	27	MA1979.1	ZNF416	MA1979.1	TATCTGGGCAH	ZNF416	0.00767	9.01e-05	599	82.7	106000	76.1	1.09	MTX_DAR_3hr
70	28	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	0.00801	9.22e-05	304	42	47700	34.2	1.23	MTX_DAR_3hr
71	29	MA1643.1	NFIB	MA1643.1	NNCCTGGCAYNGTGCCAAGNN	NFIB	0.00808	9.22e-05	269	37.2	41300	29.7	1.26	MTX_DAR_3hr
72	12	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	0.0099	0.000111	285	39.4	44300	31.8	1.24	MTX_DAR_3hr
73	1	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	0.0103	0.000115	585	80.8	103000	74	1.09	MTX_DAR_3hr
74	7	MA1719.1	ZNF816	MA1719.1	DRRKGGGGACATGCHGGG	ZNF816	0.0116	0.000126	475	65.6	80600	57.9	1.13	MTX_DAR_3hr
75	30	MA0694.1	ZBTB7B	MA0694.1	RCGACCACCGAA	ZBTB7B	0.0118	0.000126	349	48.2	56300	40.4	1.19	MTX_DAR_3hr
76	30	MA1587.1	ZNF135	MA1587.1	CCTCGACCTCCYRR	ZNF135	0.0118	0.000126	366	50.6	59500	42.7	1.19	MTX_DAR_3hr
77	30	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	0.0121	0.000127	389	53.7	63900	45.9	1.17	MTX_DAR_3hr
78	19	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	0.0148	0.000154	107	14.8	13700	9.83	1.51	MTX_DAR_3hr
79	12	MA1099.2	HES1	MA1099.2	GGCRCGTGBC	HES1	0.0153	0.000157	58	8.01	6200	4.45	1.83	MTX_DAR_3hr
80	10	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	0.0172	0.000174	158	21.8	22200	15.9	1.38	MTX_DAR_3hr
81	31	MA0597.2	THAP1	MA0597.2	VSGCAGGGCASV	THAP1	0.0204	0.000204	189	26.1	27600	19.8	1.32	MTX_DAR_3hr
82	1	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	0.0213	0.00021	223	30.8	33600	24.1	1.28	MTX_DAR_3hr
83	25	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	0.0238	0.000233	354	48.9	57600	41.4	1.18	MTX_DAR_3hr
84	32	7-AAGCCGCCCTG	STREME-7	7-AAGCCGCCCTG	AAGCCGCCCTG	AAGCCGCCCTG	0.0266	0.000257	197	27.2	29100	20.9	1.31	MTX_DAR_3hr
85	33	MA1684.1	Foxn1	MA1684.1	RGAMGC	Foxn1	0.035	0.000333	74	10.2	8790	6.31	1.64	MTX_DAR_3hr
9	34	MA1721.1 (ZNF93)	MEME-1	CCCSCSSCCGCCGCC	CCCSCSSCCGCCGCC	ZNF93	0.338	0.0375	6	0.83	466	0.33	2.88	MTX_DAR_3hr

ER_rat <- 1.25
# mrc_type <- "EAR_open"
MTX_DAR_3hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  # geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_col(aes(x=log10Evalue))+
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("MTX_DAR_3hr_combo response peaks(200bp) Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

MTX_DAR_3hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  # geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*.5), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.5,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("MTX DAR 3 hour response peaks(200bp) Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

MTX_DAR_24hr data

MTX_DAR_24hr_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_24_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
MTX_DAR_24hr_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_24_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
MTX_DAR_24hr_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_24_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
MTX_DAR_24hr_sea_all <- rbind(MTX_DAR_24hr_sea_disc, MTX_DAR_24hr_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

MTX_DAR_24hr_combo <- MTX_DAR_24hr_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., MTX_DAR_24hr_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="MTX_DAR_24hr")

MTX_DAR_24hr_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp MTX_DAR_24hr") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp MTX_DAR_24hr
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA0477.2 (FOSL1)	STREME-1	1-GATGAGTCAY	GATGAGTCAY	FOSL1	6.82e-110	4.56e-110	3560	16.3	12700	10.8	1.52	MTX_DAR_24hr
2	1	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	4.22e-99	1.41e-99	3810	17.5	14200	12	1.46	MTX_DAR_24hr
3	1	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	5.59e-96	1.25e-96	4190	19.2	16000	13.6	1.42	MTX_DAR_24hr
4	1	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	9.33e-96	1.56e-96	3600	16.5	13300	11.3	1.47	MTX_DAR_24hr
5	1	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	1.96e-95	2.62e-96	3840	17.6	14400	12.2	1.44	MTX_DAR_24hr
6	1	MA0478.1 (FOSL2)	MEME-1	MTGAGTCAYY	MTGAGTCAYY	FOSL2	3.62e-93	3.52e-94	3790	17.4	14200	12.1	1.44	MTX_DAR_24hr
7	1	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	3.68e-93	3.52e-94	4270	19.6	16500	14	1.4	MTX_DAR_24hr
8	1	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	1.12e-92	9.33e-94	3580	16.4	13300	11.3	1.46	MTX_DAR_24hr
9	1	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	1.35e-92	1e-93	4140	19	15900	13.4	1.41	MTX_DAR_24hr
10	1	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	5.58e-91	3.73e-92	4300	19.7	16700	14.1	1.39	MTX_DAR_24hr
11	1	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	1.14e-88	6.95e-90	3700	17	14000	11.8	1.43	MTX_DAR_24hr
12	1	MA0476.1 (FOS)	STREME-2	2-VTGASTCAB	VTGASTCAB	FOS	3.57e-88	1.99e-89	3890	17.8	14900	12.6	1.42	MTX_DAR_24hr
13	1	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	1.88e-86	9.65e-88	4440	20.4	17500	14.8	1.37	MTX_DAR_24hr
14	1	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	5.21e-85	2.49e-86	4600	21.1	18300	15.5	1.36	MTX_DAR_24hr
15	1	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	7.1e-85	3.16e-86	3720	17	14200	12	1.42	MTX_DAR_24hr
16	1	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	1.9e-83	7.96e-85	3810	17.5	14700	12.4	1.41	MTX_DAR_24hr
17	1	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	1.01e-82	3.95e-84	3700	16.9	14100	12	1.42	MTX_DAR_24hr
18	1	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	4.55e-81	1.69e-82	4120	18.9	16200	13.7	1.38	MTX_DAR_24hr
19	1	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	7.63e-81	2.69e-82	4890	22.4	19900	16.8	1.33	MTX_DAR_24hr
20	1	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	1.03e-80	3.44e-82	4270	19.6	16900	14.3	1.37	MTX_DAR_24hr
21	1	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	4.07e-80	1.3e-81	4690	21.5	18900	16	1.34	MTX_DAR_24hr
22	1	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	4.32e-78	1.31e-79	4500	20.6	18100	15.3	1.35	MTX_DAR_24hr
23	1	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	6.03e-76	1.75e-77	4300	19.7	17200	14.6	1.35	MTX_DAR_24hr
24	1	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	5.28e-74	1.47e-75	4570	20.9	18600	15.7	1.33	MTX_DAR_24hr
25	1	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	1.49e-73	3.99e-75	3600	16.5	14000	11.8	1.39	MTX_DAR_24hr
26	2	MA1513.1 (KLF15)	STREME-3	3-GCCCCGCCC	GCCCCGCCC	KLF15	9.43e-73	2.42e-74	1290	5.92	3800	3.21	1.84	MTX_DAR_24hr
27	1	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	1.02e-72	2.52e-74	4120	18.9	16500	14	1.35	MTX_DAR_24hr
28	1	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	2.57e-72	6.14e-74	4560	20.9	18600	15.8	1.33	MTX_DAR_24hr
29	1	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	2.56e-70	5.91e-72	4580	21	18800	15.9	1.32	MTX_DAR_24hr
30	1	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	8.54e-61	1.9e-62	4910	22.5	20800	17.6	1.28	MTX_DAR_24hr
31	3	MA1985.1 (ZNF669)	STREME-5	5-CYGTCRNCRSC	CYGTCRNCRSC	ZNF669	1.9e-54	4.11e-56	6370	29.2	28400	24	1.21	MTX_DAR_24hr
32	2	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	1.52e-51	3.18e-53	1140	5.22	3580	3.03	1.72	MTX_DAR_24hr
33	4	MA0502.2 (NFYB)	STREME-9	9-CGATTGGC	CGATTGGC	NFYB	3.15e-45	6.39e-47	961	4.4	2980	2.52	1.75	MTX_DAR_24hr
34	2	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	1.71e-44	3.36e-46	3090	14.1	12600	10.7	1.32	MTX_DAR_24hr
35	2	MA0742.2 (KLF12)	STREME-11	11-CCCGGCC	11-CCCGGCC	KLF12	1.26e-43	2.41e-45	3530	16.2	14800	12.5	1.29	MTX_DAR_24hr
36	5	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	4.32e-40	8.03e-42	3050	14	12600	10.7	1.31	MTX_DAR_24hr
37	6	6-CCGSSSCGG	STREME-6	6-CCGSSSCGG	CCGSSSCGG	CCGSSSCGG	2.17e-39	3.92e-41	1940	8.88	7430	6.29	1.41	MTX_DAR_24hr
38	2	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	2.82e-39	4.96e-41	3700	17	15900	13.4	1.26	MTX_DAR_24hr
39	2	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	1.92e-38	3.29e-40	3180	14.6	13300	11.3	1.29	MTX_DAR_24hr
40	7	10-CGGCSGCCG	STREME-10	10-CGGCSGCCG	10-CGGCSGCCG	CGGCSGCCG	4.56e-38	7.62e-40	1620	7.41	6000	5.08	1.46	MTX_DAR_24hr
41	2	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	2.65e-36	4.32e-38	2870	13.2	11900	10.1	1.3	MTX_DAR_24hr
42	22	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	9.97e-36	1.59e-37	3240	14.9	13800	11.7	1.27	MTX_DAR_24hr
43	2	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	1.11e-35	1.73e-37	2610	12	10700	9.08	1.32	MTX_DAR_24hr
44	8	12-CGGGCC	STREME-12	12-CGGGCC	12-CGGGCC	CGGGCC	3.75e-35	5.7e-37	3240	14.9	13800	11.7	1.27	MTX_DAR_24hr
45	9	MA0516.3 (SP2)	MEME-3	GCGGCGGSGSSSGCG	GCGGCGGSGSSSGCG	SP2	1.37e-34	2.03e-36	1580	7.24	5950	5.03	1.44	MTX_DAR_24hr
46	2	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	3.57e-34	5.18e-36	4100	18.8	18100	15.3	1.23	MTX_DAR_24hr
47	10	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	5.13e-33	7.29e-35	6760	31	31700	26.8	1.15	MTX_DAR_24hr
48	2	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	6.51e-32	9.06e-34	2840	13	12000	10.2	1.28	MTX_DAR_24hr
49	11	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	7.02e-32	9.58e-34	5020	23	22900	19.3	1.19	MTX_DAR_24hr
50	2	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	9.96e-32	1.33e-33	2410	11	9950	8.42	1.31	MTX_DAR_24hr
51	5	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	1.23e-31	1.61e-33	5570	25.5	25700	21.7	1.17	MTX_DAR_24hr
52	1	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	3.49e-31	4.49e-33	5200	23.8	23800	20.2	1.18	MTX_DAR_24hr
53	2	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	3.89e-31	4.9e-33	3020	13.8	12900	10.9	1.27	MTX_DAR_24hr
54	12	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	5.33e-31	6.6e-33	3020	13.8	12900	10.9	1.27	MTX_DAR_24hr
55	2	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	1.81e-30	2.2e-32	2890	13.2	12300	10.4	1.27	MTX_DAR_24hr
56	2	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	1.86e-30	2.22e-32	2660	12.2	11200	9.47	1.29	MTX_DAR_24hr
57	1	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	4.69e-29	5.51e-31	4300	19.7	19400	16.4	1.2	MTX_DAR_24hr
58	2	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	1.55e-28	1.79e-30	4290	19.7	19400	16.4	1.2	MTX_DAR_24hr
59	4	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	1.74e-27	1.97e-29	3270	15	14300	12.1	1.23	MTX_DAR_24hr
60	2	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	2.98e-27	3.32e-29	4570	20.9	20900	17.6	1.19	MTX_DAR_24hr
61	13	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	5.29e-27	5.8e-29	2510	11.5	10600	9	1.28	MTX_DAR_24hr
62	2	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	1.88e-26	2.03e-28	5520	25.3	25800	21.8	1.16	MTX_DAR_24hr
63	4	MA0502.2	NFYB	MA0502.2	CYCATTGGCCVV	NFYB	6.74e-25	7.15e-27	2630	12	11300	9.6	1.26	MTX_DAR_24hr
64	2	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	1.06e-24	1.11e-26	3630	16.6	16300	13.8	1.21	MTX_DAR_24hr
65	1	MA1114.1	PBX3	MA1114.1	NNNTGAGTGACAGGBNN	PBX3	2.38e-24	2.44e-26	10900	50	54400	46	1.09	MTX_DAR_24hr
66	14	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	2.34e-23	2.37e-25	7150	32.8	34500	29.2	1.12	MTX_DAR_24hr
67	2	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	3.2e-23	3.19e-25	3940	18.1	18000	15.2	1.19	MTX_DAR_24hr
68	2	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	5.11e-23	5.02e-25	4750	21.8	22100	18.7	1.16	MTX_DAR_24hr
69	5	MA0732.1	EGR3	MA0732.1	HHMCGCCCACGCAHH	EGR3	1.17e-22	1.13e-24	2970	13.6	13100	11.1	1.22	MTX_DAR_24hr
70	2	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	1.8e-22	1.72e-24	3540	16.2	16000	13.6	1.2	MTX_DAR_24hr
71	5	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	3.06e-22	2.89e-24	3130	14.3	13900	11.8	1.21	MTX_DAR_24hr
72	15	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	3.89e-22	3.62e-24	2440	11.2	10500	8.93	1.25	MTX_DAR_24hr
73	16	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	7.75e-22	7.1e-24	5340	24.4	25200	21.3	1.15	MTX_DAR_24hr
74	16	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	3.59e-21	3.24e-23	5250	24	24800	21	1.15	MTX_DAR_24hr
75	2	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	1.27e-20	1.13e-22	1730	7.95	7210	6.1	1.3	MTX_DAR_24hr
76	2	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	1.69e-20	1.48e-22	5590	25.6	26600	22.5	1.14	MTX_DAR_24hr
77	1	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	1.02e-19	8.83e-22	3010	13.8	13500	11.4	1.21	MTX_DAR_24hr
78	2	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	2.07e-18	1.78e-20	7820	35.8	38400	32.5	1.1	MTX_DAR_24hr
79	17	MA1155.1 (ZSCAN4)	STREME-7	7-ACATGCACACACGT	ACATGCACACACGT	ZSCAN4	3.27e-18	2.77e-20	355	1.63	1050	0.89	1.83	MTX_DAR_24hr
80	18	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	5.34e-18	4.47e-20	1510	6.94	6280	5.32	1.31	MTX_DAR_24hr
81	19	MA0774.1	MEIS2	MA0774.1	TTGACAGS	MEIS2	1.14e-17	9.4e-20	1830	8.37	7800	6.6	1.27	MTX_DAR_24hr
82	20	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	2.02e-17	1.65e-19	5240	24	25100	21.2	1.13	MTX_DAR_24hr
83	1	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	1.19e-16	9.6e-19	5780	26.5	27900	23.6	1.12	MTX_DAR_24hr
84	1	MA0150.2	Nfe2l2	MA0150.2	CASNATGACTCAGCA	Nfe2l2	1.24e-16	9.91e-19	8210	37.6	40700	34.4	1.09	MTX_DAR_24hr
85	1	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	1.45e-16	1.14e-18	12500	57.1	63600	53.8	1.06	MTX_DAR_24hr
86	21	MA1573.2	Thap11	MA1573.2	ACTACAABTCCCAG	Thap11	1.53e-16	1.19e-18	99	0.45	155	0.13	3.47	MTX_DAR_24hr
87	22	MA1653.1 (ZNF148)	STREME-4	4-CCCCTCCCC	CCCCTCCCC	ZNF148	1.75e-16	1.34e-18	2580	11.8	11600	9.79	1.21	MTX_DAR_24hr
88	5	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	2.29e-16	1.74e-18	17600	80.5	91900	77.8	1.03	MTX_DAR_24hr
89	23	MA1569.1	TFAP2E	MA1569.1	YGCCYSRGGCD	TFAP2E	6.14e-16	4.62e-18	3740	17.1	17500	14.8	1.16	MTX_DAR_24hr
90	24	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	1.65e-15	1.23e-17	4260	19.5	20200	17.1	1.14	MTX_DAR_24hr
91	25	MA1643.1	NFIB	MA1643.1	NNCCTGGCAYNGTGCCAAGNN	NFIB	1.79e-15	1.32e-17	5720	26.2	27700	23.4	1.12	MTX_DAR_24hr
92	26	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	1.99e-15	1.44e-17	7530	34.5	37200	31.5	1.1	MTX_DAR_24hr
93	24	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	2.97e-15	2.14e-17	998	4.57	3970	3.36	1.36	MTX_DAR_24hr
94	24	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	1.4e-14	9.97e-17	2930	13.4	13400	11.4	1.18	MTX_DAR_24hr
95	27	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	2.05e-14	1.44e-16	1180	5.4	4850	4.1	1.32	MTX_DAR_24hr
96	23	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	2.27e-14	1.58e-16	10100	46.2	51000	43.2	1.07	MTX_DAR_24hr
97	24	MA0603.1	Arntl	MA0603.1	NGTCACGTGH	Arntl	5.78e-14	3.98e-16	14900	68.2	77300	65.4	1.04	MTX_DAR_24hr
98	13	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	7.34e-14	5.01e-16	2750	12.6	12600	10.7	1.18	MTX_DAR_24hr
99	5	MA1656.1	ZNF449	MA1656.1	NNAAGCCCAACCNN	ZNF449	1.03e-13	6.97e-16	9700	44.4	49000	41.4	1.07	MTX_DAR_24hr
100	5	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	2.93e-13	1.96e-15	9230	42.3	46500	39.4	1.07	MTX_DAR_24hr
101	13	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	2.99e-13	1.98e-15	655	3	2460	2.09	1.44	MTX_DAR_24hr
102	28	MA1995.1	Npas4	MA1995.1	NNTCGTGACHN	Npas4	3.77e-13	2.47e-15	11800	54	60400	51.1	1.06	MTX_DAR_24hr
103	29	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	6.59e-13	4.28e-15	8920	40.9	44900	38	1.08	MTX_DAR_24hr
104	22	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	1.33e-12	8.56e-15	2940	13.5	13700	11.6	1.17	MTX_DAR_24hr
105	30	MA0615.1	Gmeb1	MA0615.1	BHBBKKACGTMMNWNNN	Gmeb1	2.48e-12	1.58e-14	1970	9.03	8820	7.46	1.21	MTX_DAR_24hr
106	23	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	5.25e-12	3.31e-14	8610	39.4	43400	36.7	1.08	MTX_DAR_24hr
107	31	MA0067.2	PAX2	MA0067.2	BCAVTSRAGCGTGACGR	PAX2	9.01e-12	5.63e-14	5190	23.8	25300	21.4	1.11	MTX_DAR_24hr
108	32	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	1.03e-11	6.39e-14	4730	21.7	23000	19.4	1.12	MTX_DAR_24hr
109	24	MA0464.2	BHLHE40	MA0464.2	VKCACGTGMC	BHLHE40	1.04e-11	6.4e-14	8190	37.5	41200	34.8	1.08	MTX_DAR_24hr
110	28	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	1.72e-11	1.05e-13	1450	6.64	6310	5.34	1.25	MTX_DAR_24hr
111	13	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	3.2e-11	1.93e-13	4780	21.9	23200	19.7	1.11	MTX_DAR_24hr
112	19	MA1572.1	TGIF2LY	MA1572.1	TGACAGCTGTCA	TGIF2LY	5.41e-11	3.23e-13	13700	62.6	70800	59.9	1.04	MTX_DAR_24hr
113	33	MA1964.1	SMAD2	MA1964.1	NBCCAGACDN	SMAD2	7.07e-11	4.19e-13	14900	68.4	77800	65.8	1.04	MTX_DAR_24hr
114	34	MA0803.1	TBX15	MA0803.1	AGGTGTGA	TBX15	8.2e-11	4.81e-13	17300	79.4	91200	77.2	1.03	MTX_DAR_24hr
115	3	MA1985.1	ZNF669	MA1985.1	GGGGYGAYGACCRCT	ZNF669	1.38e-10	7.99e-13	1040	4.76	4360	3.69	1.29	MTX_DAR_24hr
116	25	MA1528.1	NFIX	MA1528.1	STTGGCRNNGTGCCARB	NFIX	1.39e-10	8e-13	3050	14	14400	12.2	1.15	MTX_DAR_24hr
117	35	MA1557.1	SMAD5	MA1557.1	YGTCTAGACA	SMAD5	1.61e-10	9.2e-13	11000	50.4	56400	47.7	1.06	MTX_DAR_24hr
118	22	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	3.22e-10	1.83e-12	3710	17	17800	15.1	1.13	MTX_DAR_24hr
119	24	MA0616.2	HES2	MA0616.2	GGCACGTGYC	HES2	5.41e-10	3.04e-12	1800	8.24	8120	6.87	1.2	MTX_DAR_24hr
120	36	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	5.9e-10	3.29e-12	11200	51.3	57600	48.7	1.05	MTX_DAR_24hr
121	17	MA1124.1 (ZNF24)	STREME-8	8-CACACATGCATGC	CACACATGCATGC	ZNF24	9.63e-10	5.32e-12	456	2.09	1680	1.42	1.47	MTX_DAR_24hr
122	22	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	1.32e-09	7.23e-12	8640	39.6	43800	37.1	1.07	MTX_DAR_24hr
123	37	MA0767.1	GCM2	MA0767.1	BATGCGGGTR	GCM2	1.36e-09	7.39e-12	9600	44	49000	41.4	1.06	MTX_DAR_24hr
124	2	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	1.46e-09	7.87e-12	3510	16.1	16800	14.2	1.13	MTX_DAR_24hr
125	38	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	2.07e-09	1.11e-11	2650	12.1	12400	10.5	1.15	MTX_DAR_24hr
126	39	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	2.93e-09	1.56e-11	925	4.24	3890	3.29	1.29	MTX_DAR_24hr
127	19	MA1571.1	TGIF2LX	MA1571.1	TGACAGCTGTCA	TGIF2LX	8.84e-09	4.65e-11	11000	50.3	56500	47.8	1.05	MTX_DAR_24hr
128	40	MA0813.1	TFAP2B	MA0813.1	TGCCCYBRGGGCA	TFAP2B	1.33e-08	6.96e-11	1770	8.13	8100	6.85	1.19	MTX_DAR_24hr
129	40	MA0872.1	TFAP2A	MA0872.1	TGCCCYSRGGGCA	TFAP2A	1.64e-08	8.51e-11	1420	6.48	6320	5.35	1.21	MTX_DAR_24hr
130	41	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	1.7e-08	8.72e-11	13800	63.3	72000	60.9	1.04	MTX_DAR_24hr
131	38	MA0750.2	ZBTB7A	MA0750.2	NVCCGGAAGTGSV	ZBTB7A	1.83e-08	9.33e-11	901	4.13	3810	3.23	1.28	MTX_DAR_24hr
132	41	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	1.86e-08	9.44e-11	12800	58.7	66500	56.3	1.04	MTX_DAR_24hr
133	2	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	2.52e-08	1.27e-10	986	4.52	4230	3.58	1.26	MTX_DAR_24hr
134	24	MA1464.1	ARNT2	MA1464.1	GTCACGTGMN	ARNT2	2.8e-08	1.4e-10	7270	33.3	36700	31.1	1.07	MTX_DAR_24hr
135	24	MA1099.2	HES1	MA1099.2	GGCRCGTGBC	HES1	7.68e-08	3.8e-10	649	2.97	2640	2.24	1.33	MTX_DAR_24hr
136	42	MA1973.1	ZKSCAN3	MA1973.1	KDKCCCAGGCTAGCCCABNN	ZKSCAN3	1.27e-07	6.24e-10	9430	43.2	48400	40.9	1.06	MTX_DAR_24hr
137	38	MA0764.3	ETV4	MA0764.3	ACCGGAAGTR	ETV4	2.26e-07	1.1e-09	266	1.22	917	0.78	1.57	MTX_DAR_24hr
138	23	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	2.27e-07	1.1e-09	18000	82.5	95400	80.7	1.02	MTX_DAR_24hr
139	43	MA1155.1	ZSCAN4	MA1155.1	TGCACACACTGAAAA	ZSCAN4	3.73e-07	1.8e-09	315	1.44	1140	0.96	1.5	MTX_DAR_24hr
140	36	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	3.89e-07	1.86e-09	11500	52.6	59500	50.3	1.04	MTX_DAR_24hr
141	24	MA0499.2	MYOD1	MA0499.2	NNGCACCTGTCNB	MYOD1	4.77e-07	2.26e-09	20600	94.6	110000	93.5	1.01	MTX_DAR_24hr
142	30	MA1475.1	CREB3L4	MA1475.1	GRTGACGTCAYC	CREB3L4	1.19e-06	5.61e-09	10900	50.1	56600	47.9	1.05	MTX_DAR_24hr
143	4	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	1.24e-06	5.8e-09	38	0.17	52	0.04	3.98	MTX_DAR_24hr
144	19	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	1.25e-06	5.81e-09	14800	68	77900	65.9	1.03	MTX_DAR_24hr
145	24	MA0608.1	Creb3l2	MA0608.1	GCCACGTGD	Creb3l2	1.46e-06	6.74e-09	5810	26.6	29200	24.7	1.08	MTX_DAR_24hr
146	24	MA0692.1	TFEB	MA0692.1	RYCACGTGAC	TFEB	1.86e-06	8.52e-09	8830	40.5	45300	38.4	1.06	MTX_DAR_24hr
147	22	MA0528.2	ZNF263	MA0528.2	VNGGGGAGGASG	ZNF263	2.51e-06	1.14e-08	6170	28.3	31100	26.4	1.07	MTX_DAR_24hr
148	24	MA0147.3	MYC	MA0147.3	NNCCACGTGCNB	MYC	2.89e-06	1.31e-08	16600	76.1	87800	74.3	1.02	MTX_DAR_24hr
149	38	MA0076.2	ELK4	MA0076.2	BCRCTTCCGGB	ELK4	3.11e-06	1.39e-08	197	0.9	651	0.55	1.64	MTX_DAR_24hr
150	24	MA1106.1	HIF1A	MA1106.1	SBACGTGCNN	HIF1A	3.86e-06	1.72e-08	4540	20.8	22600	19.1	1.09	MTX_DAR_24hr
151	40	MA0815.1	TFAP2C	MA0815.1	TGCCCYSRGGGCA	TFAP2C	4.97e-06	2.2e-08	1150	5.26	5160	4.36	1.21	MTX_DAR_24hr
152	19	MA0775.1	MEIS3	MA0775.1	DTGACAGS	MEIS3	5.65e-06	2.48e-08	10500	47.9	54100	45.8	1.05	MTX_DAR_24hr
153	44	MA1730.1	ZNF708	MA1730.1	NNRGCTGTRCCTCCY	ZNF708	6.61e-06	2.89e-08	11900	54.6	62000	52.5	1.04	MTX_DAR_24hr
154	45	MA1727.1	ZNF417	MA1727.1	VRBVNTGGGCGCCAM	ZNF417	2.25e-05	9.77e-08	4930	22.6	24700	20.9	1.08	MTX_DAR_24hr
155	1	MA1143.1	FOSL1::JUND	MA1143.1	RTGACGTMAY	FOSL1::JUND	3.22e-05	1.39e-07	13000	59.4	67900	57.5	1.03	MTX_DAR_24hr
156	36	MA1628.1	Zic1::Zic2	MA1628.1	CVCAGCAGGNV	Zic1::Zic2	3.29e-05	1.41e-07	9550	43.8	49400	41.8	1.05	MTX_DAR_24hr
157	36	MA1966.1	TFAP4::ETV1	MA1966.1	RSCGGAAGCAGSTGKN	TFAP4::ETV1	5.39e-05	2.3e-07	4150	19	20700	17.5	1.09	MTX_DAR_24hr
158	30	MA0609.2	CREM	MA0609.2	NNDGTGACGTCACHNN	CREM	5.44e-05	2.3e-07	13800	63.1	72300	61.2	1.03	MTX_DAR_24hr
159	24	MA0093.3	USF1	MA0093.3	NDGTCATGTGACHN	USF1	6.13e-05	2.58e-07	14200	64.9	74500	63.1	1.03	MTX_DAR_24hr
160	23	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	0.000129	5.39e-07	502	2.3	2100	1.77	1.3	MTX_DAR_24hr
161	38	MA0028.2	ELK1	MA0028.2	ACCGGAAGTR	ELK1	0.000142	5.88e-07	362	1.66	1440	1.22	1.36	MTX_DAR_24hr
162	38	MA0156.3	FEV	MA0156.3	VACCGGAAGTVV	FEV	0.00018	7.45e-07	443	2.03	1820	1.54	1.32	MTX_DAR_24hr
163	37	MA0646.1	GCM1	MA0646.1	BATGCGGGTAC	GCM1	0.000252	1.03e-06	4020	18.4	20100	17	1.08	MTX_DAR_24hr
164	36	MA1638.1	HAND2	MA1638.1	NVCAGATGNN	HAND2	0.000256	1.04e-06	11000	50.3	57300	48.4	1.04	MTX_DAR_24hr
165	45	MA0024.3	E2F1	MA0024.3	TTTGGCGCCAAA	E2F1	0.00036	1.46e-06	2640	12.1	12900	10.9	1.11	MTX_DAR_24hr
166	38	MA0645.1	ETV6	MA0645.1	MSCGGAAGTR	ETV6	0.000377	1.52e-06	154	0.71	519	0.44	1.61	MTX_DAR_24hr
167	20	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	0.000555	2.22e-06	11900	54.7	62500	52.9	1.03	MTX_DAR_24hr
168	1	MA0591.1	Bach1::Mafk	MA0591.1	RSSATGACTCAGCAB	Bach1::Mafk	0.00102	4.08e-06	1280	5.86	6000	5.07	1.16	MTX_DAR_24hr
169	46	MA1149.1	RARA::RXRG	MA1149.1	RRGGTCAHNNNRRGGTCA	RARA::RXRG	0.00126	4.98e-06	6380	29.2	32700	27.7	1.06	MTX_DAR_24hr
170	47	MA0155.1	INSM1	MA0155.1	TGYCWGGGGGCR	INSM1	0.00135	5.31e-06	3490	16	17400	14.8	1.08	MTX_DAR_24hr
171	38	MA1708.1	ETV7	MA1708.1	DGSCGGAAGTR	ETV7	0.00222	8.68e-06	397	1.82	1660	1.4	1.3	MTX_DAR_24hr
172	24	MA0649.1	HEY2	MA0649.1	GRCACGTGYC	HEY2	0.00245	9.51e-06	15400	70.6	81600	69.1	1.02	MTX_DAR_24hr
173	48	MA1711.1	ZNF343	MA1711.1	CCGCTTCMCCDCGGCMV	ZNF343	0.00286	1.1e-05	2540	11.7	12500	10.6	1.1	MTX_DAR_24hr
174	23	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	0.00304	1.17e-05	624	2.86	2760	2.34	1.22	MTX_DAR_24hr
175	38	MA0098.3	ETS1	MA0098.3	ACCGGAARTR	ETS1	0.004	1.53e-05	413	1.89	1740	1.48	1.28	MTX_DAR_24hr
176	45	MA0864.2	E2F2	MA0864.2	RWTTTGGCGCCAWWWY	E2F2	0.00553	2.1e-05	3250	14.9	16300	13.8	1.08	MTX_DAR_24hr
177	24	MA0620.3	MITF	MA0620.3	NNNDRTCACGTGAYHNNN	MITF	0.00564	2.13e-05	13900	63.9	73600	62.3	1.02	MTX_DAR_24hr
178	38	MA0765.3	ETV5	MA0765.3	ACCGGAAGTR	ETV5	0.00567	2.13e-05	1860	8.52	9040	7.65	1.11	MTX_DAR_24hr
179	20	MA0163.1	PLAG1	MA0163.1	GGGGCCCWAGGGGG	PLAG1	0.00653	2.44e-05	2410	11	11900	10	1.1	MTX_DAR_24hr
180	24	MA0058.3	MAX	MA0058.3	AVCACGTGNY	MAX	0.00927	3.45e-05	10500	48.3	55300	46.8	1.03	MTX_DAR_24hr
181	24	MA0004.1	Arnt	MA0004.1	CACGTG	Arnt	0.00971	3.59e-05	3820	17.5	19300	16.4	1.07	MTX_DAR_24hr
182	24	MA0831.3	TFE3	MA0831.3	GTCACGTGAC	TFE3	0.00976	3.59e-05	3990	18.3	20200	17.1	1.07	MTX_DAR_24hr
183	1	MA1521.1	MAFA	MA1521.1	NTGCTGASTCAGCAN	MAFA	0.0119	4.34e-05	18100	82.7	96400	81.6	1.01	MTX_DAR_24hr
184	24	MA0259.1	ARNT::HIF1A	MA0259.1	VBACGTGC	ARNT::HIF1A	0.0119	4.34e-05	1610	7.37	7790	6.59	1.12	MTX_DAR_24hr
185	34	MA1566.2	TBX3	MA1566.2	RAGGTGTGAAV	TBX3	0.0127	4.58e-05	5400	24.7	27700	23.4	1.06	MTX_DAR_24hr
186	49	MA1716.1	ZNF76	MA1716.1	NNTWCCCAYAATGCAHYGCGC	ZNF76	0.0132	4.74e-05	137	0.63	486	0.41	1.53	MTX_DAR_24hr
187	50	MA0656.1	JDP2	MA0656.1	GATGACGTCAYC	JDP2	0.0139	4.96e-05	90	0.41	286	0.24	1.72	MTX_DAR_24hr
188	24	MA1493.1	HES6	MA1493.1	GGCACGTGTY	HES6	0.0161	5.73e-05	8320	38.1	43300	36.7	1.04	MTX_DAR_24hr
189	51	MA1982.1	ZNF574	MA1982.1	VGSCTAGAGMGGCCS	ZNF574	0.0171	6.05e-05	598	2.74	2680	2.27	1.21	MTX_DAR_24hr
190	38	MA0475.2	FLI1	MA0475.2	ACCGGAARTR	FLI1	0.0203	7.13e-05	341	1.56	1440	1.22	1.29	MTX_DAR_24hr
191	52	MA0705.1	Lhx8	MA0705.1	CTAATTAV	Lhx8	0.0217	7.61e-05	12100	55.6	64000	54.1	1.03	MTX_DAR_24hr
192	24	MA0819.2	CLOCK	MA0819.2	NRACACGTGB	CLOCK	0.0232	8.07e-05	7740	35.5	40200	34	1.04	MTX_DAR_24hr
193	24	MA0664.1	MLXIPL	MA0664.1	RTCACGTGAT	MLXIPL	0.0233	8.09e-05	12100	55.6	63900	54.1	1.03	MTX_DAR_24hr
194	53	MA1971.1	ZBED2	MA1971.1	NNMMCGAAACCNNV	ZBED2	0.0252	8.68e-05	1020	4.67	4810	4.07	1.15	MTX_DAR_24hr
195	54	MA1645.1	NKX2-2	MA1645.1	NNNCCACTCAANNN	NKX2-2	0.0259	8.88e-05	5090	23.3	26100	22.1	1.06	MTX_DAR_24hr
196	24	MA1560.1	SOHLH2	MA1560.1	YGCACGTGCN	SOHLH2	0.0277	9.45e-05	457	2.09	2000	1.7	1.24	MTX_DAR_24hr
197	36	MA0697.2	Zic3	MA0697.2	CNCAGCAGGAGNN	Zic3	0.0291	9.88e-05	12300	56.5	65000	55	1.03	MTX_DAR_24hr
198	24	MA1474.1	CREB3L4	MA1474.1	YGCCACGTCAYC	CREB3L4	0.03	0.000101	152	0.7	563	0.48	1.47	MTX_DAR_24hr
199	55	MA1710.1	ZNF257	MA1710.1	VDGAGGCRAGRG	ZNF257	0.0357	0.00012	13900	63.8	73700	62.4	1.02	MTX_DAR_24hr
200	38	MA1484.1	ETS2	MA1484.1	DACCGGAAGY	ETS2	0.0367	0.000123	246	1.13	998	0.84	1.34	MTX_DAR_24hr
201	32	MA1587.1	ZNF135	MA1587.1	CCTCGACCTCCYRR	ZNF135	0.038	0.000126	9650	44.2	50500	42.8	1.03	MTX_DAR_24hr
202	56	MA1731.1	ZNF768	MA1731.1	YBVCYBRSCCTCTCTGDG	ZNF768	0.0487	0.000161	4240	19.4	21600	18.3	1.06	MTX_DAR_24hr
15	57	MA1125.1 (ZNF384)	MEME-2	AAAAAAAAAAAAAAA	AAAAAAAAAAAAAAA	ZNF384	15	1	1700	7.78	10700	9.03	0.863	MTX_DAR_24hr

ER_rat <- 1.25
mrc_type <- "MTX_DAR_24hr"
MTX_DAR_24hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

MTX_DAR_24hr_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,mrc_type,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  dplyr::filter(EVALUE.y<0.05) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*.8), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.8,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

MTX_DAR 24 2kb data

MTX_242kb_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_24_2kb_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
MTX_242kb_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_24_2kb_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
MTX_242kb_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_24_2kb_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
MTX_242kb_sea_all <- rbind(MTX_242kb_sea_disc, MTX_242kb_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

MTX_242kb_combo <- MTX_242kb_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., MTX_242kb_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

MTX_242kb_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in MTX_24 2kb") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in MTX_24 2kb
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA0060.3 (NFYA)	STREME-2	2-YSATTGGYY	YSATTGGYY	NFYA	3.44e-70	2.66e-70	486	8.15	737	2.73	2.98
2	2	MA0516.3 (SP2)	STREME-1	1-GCCCCGCCCC	GCCCCGCCCC	SP2	1.91e-57	7.39e-58	998	16.7	2470	9.14	1.83
3	1	MA0502.2	NFYB	MA0502.2	CYCATTGGCCVV	NFYB	3.22e-44	8.3e-45	279	4.68	387	1.43	3.26
4	3	3-CGCGCCGG	STREME-3	3-CGCGCCGG	CGCGCCGG	CGCGCCGG	7.94e-43	1.54e-43	2960	49.5	10700	39.5	1.25
5	4	MA0146.2 (Zfx)	STREME-7	7-AGGCCGG	AGGCCGG	Zfx	1.8e-40	2.78e-41	2310	38.7	7940	29.4	1.31
6	2	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	4.47e-40	5.77e-41	1390	23.3	4220	15.7	1.49
7	2	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	1.15e-37	1.27e-38	1390	23.2	4270	15.8	1.47
8	2	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	3.24e-35	3.14e-36	1430	24	4520	16.7	1.44
9	2	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	1.69e-33	1.45e-34	944	15.8	2680	9.95	1.59
10	2	MA1961.1 (PATZ1)	MEME-1	CCCCGCCSCCSCCSC	CCCCGCCSCCSCCSC	PATZ1	1.08e-32	8.36e-34	3210	53.8	12100	44.9	1.2
11	2	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	8.39e-32	5.91e-33	3030	50.8	11400	42.1	1.21
12	2	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	1.74e-31	1.12e-32	1980	33.2	6840	25.4	1.31
13	2	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	2.32e-31	1.38e-32	1140	19.2	3480	12.9	1.49
14	2	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	5.88e-30	3.25e-31	1170	19.7	3630	13.5	1.46
15	2	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	3.23e-29	1.67e-30	3030	50.7	11400	42.4	1.2
16	2	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	1.26e-28	6.11e-30	2790	46.8	10400	38.6	1.21
17	2	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	1.18e-26	5.38e-28	3270	54.8	12600	46.8	1.17
18	2	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	4.56e-24	1.96e-25	912	15.3	2770	10.3	1.49
19	2	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	5.17e-24	2.11e-25	3290	55.2	12800	47.5	1.16
20	2	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	6.62e-23	2.56e-24	3240	54.3	12600	46.9	1.16
21	2	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	9.66e-23	3.49e-24	3920	65.8	15800	58.5	1.12
22	1	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	9.92e-23	3.49e-24	235	3.94	440	1.63	2.42
23	5	9-SGCGCS	STREME-9	9-SGCGCS	SGCGCS	SGCGCS	2.01e-21	6.76e-23	3570	59.9	14200	52.7	1.14
24	6	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	4.32e-21	1.39e-22	2450	41.1	9200	34.1	1.2
25	7	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	7.75e-21	2.4e-22	3530	59.2	14000	52	1.14
26	1	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	1.47e-20	4.38e-22	168	2.82	272	1.01	2.8
27	2	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	2.58e-19	7.41e-21	2960	49.7	11500	42.8	1.16
28	2	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	4.96e-19	1.37e-20	3210	53.8	12700	46.9	1.15
29	2	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	1.73e-17	4.63e-19	4070	68.2	16700	62	1.1
30	7	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	1.9e-17	4.91e-19	4160	69.8	17100	63.6	1.1
31	2	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	5.98e-17	1.49e-18	4320	72.4	17900	66.4	1.09
32	8	4-CGGCCC	STREME-4	4-CGGCCC	CGGCCC	CGGCCC	1.43e-16	3.46e-18	4230	70.9	17500	64.9	1.09
33	1	MA0502.2 (NFYB)	STREME-10	10-ATTGGCC	10-ATTGGCC	NFYB	5.56e-16	1.31e-17	102	1.71	136	0.5	3.4
34	9	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	8.53e-15	1.94e-16	3960	66.4	16300	60.5	1.1
35	2	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	1.2e-14	2.67e-16	3620	60.7	14700	54.7	1.11
36	11	MA1573.2	Thap11	MA1573.2	ACTACAABTCCCAG	Thap11	2.36e-14	5.07e-16	94	1.58	127	0.47	3.35
37	10	12-CCGSCGG	STREME-12	12-CCGSCGG	12-CCGSCGG	CCGSCGG	2.92e-13	6.12e-15	4150	69.5	17300	64	1.09
38	11	MA1573.2 (Thap11)	STREME-11	11-ACTACAAYTCCCAGV	11-ACTACAAYTCCCAGV	Thap11	6.29e-13	1.28e-14	152	2.55	297	1.1	2.32
39	12	MA1938.1 (ERF::NHLH1)	STREME-8	8-GCCGGA	GCCGGA	ERF::NHLH1	1.8e-12	3.58e-14	4120	69.1	17200	63.8	1.08
40	7	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	1.87e-12	3.63e-14	3650	61.2	15000	55.6	1.1
41	13	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	5.47e-12	1.03e-13	4240	71.1	17800	65.9	1.08
42	2	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	6.62e-12	1.22e-13	2410	40.4	9470	35.1	1.15
43	14	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	7.43e-12	1.34e-13	1560	26.2	5820	21.6	1.22
44	2	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	1.17e-11	2.05e-13	4120	69.1	17200	63.9	1.08
45	15	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	1.63e-11	2.8e-13	3760	63	15600	57.7	1.09
46	16	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	1.94e-11	3.26e-13	3250	54.5	13200	49.1	1.11
47	17	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	6.03e-11	9.94e-13	1980	33.1	7620	28.3	1.17
48	18	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	1.4e-10	2.26e-12	2930	49.2	11900	44	1.12
49	19	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	1.65e-10	2.61e-12	884	14.8	3060	11.4	1.31
50	20	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	2.63e-10	4.07e-12	3540	59.3	14600	54.2	1.09
51	7	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	4.97e-10	7.55e-12	3590	60.1	14900	55.1	1.09
52	7	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	5.22e-10	7.78e-12	1490	25	5600	20.8	1.2
53	9	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	7.01e-10	1.02e-11	2830	47.5	11400	42.4	1.12
54	2	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	1.5e-09	2.15e-11	894	15	3140	11.6	1.29
55	21	MA0024.3	E2F1	MA0024.3	TTTGGCGCCAAA	E2F1	3.28e-09	4.62e-11	2960	49.7	12100	44.8	1.11
56	22	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	8.7e-09	1.2e-10	370	6.2	1110	4.12	1.51
57	23	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	8.9e-09	1.21e-10	2210	37.1	8770	32.5	1.14
58	24	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	1.06e-08	1.41e-10	2470	41.4	9900	36.7	1.13
59	19	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	1.19e-08	1.56e-10	2230	37.4	8870	32.9	1.14
60	14	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	1.61e-08	2.08e-10	3440	57.7	14300	53	1.09
61	19	MA0765.3	ETV5	MA0765.3	ACCGGAAGTR	ETV5	3.21e-08	4.01e-10	778	13	2720	10.1	1.29
62	25	MA1134.1 (FOS::JUNB)	STREME-6	6-KATGAGTCATCM	KATGAGTCATCM	FOS::JUNB	3.21e-08	4.01e-10	272	4.56	767	2.84	1.61
63	26	MA1569.1	TFAP2E	MA1569.1	YGCCYSRGGCD	TFAP2E	8.59e-08	1.06e-09	1910	32	7500	27.8	1.15
64	25	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	1.05e-07	1.27e-09	4680	78.5	20100	74.7	1.05
65	27	MA0872.1	TFAP2A	MA0872.1	TGCCCYSRGGGCA	TFAP2A	1.1e-07	1.31e-09	2220	37.1	8850	32.8	1.13
66	25	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	1.52e-07	1.78e-09	335	5.62	1010	3.76	1.5
67	26	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	1.79e-07	2.06e-09	4590	77	19700	73	1.05
68	19	MA0764.3	ETV4	MA0764.3	ACCGGAAGTR	ETV4	2e-07	2.27e-09	779	13.1	2760	10.2	1.28
69	19	MA0076.2	ELK4	MA0076.2	BCRCTTCCGGB	ELK4	2.06e-07	2.32e-09	258	4.32	734	2.72	1.59
70	28	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	4.37e-07	4.83e-09	5000	83.8	21700	80.4	1.04
71	26	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	7.41e-07	8.09e-09	4630	77.6	19900	73.9	1.05
72	29	MA1985.1	ZNF669	MA1985.1	GGGGYGAYGACCRCT	ZNF669	8.2e-07	8.83e-09	3710	62.2	15600	58	1.07
73	21	MA0470.2	E2F4	MA0470.2	TTTTGGCGCCAWWW	E2F4	8.73e-07	9.27e-09	1780	29.8	6990	25.9	1.15
74	7	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	1.51e-06	1.57e-08	4810	80.7	20800	77.2	1.05
75	25	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	1.52e-06	1.57e-08	354	5.93	1110	4.12	1.44
76	40	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	2.48e-06	2.53e-08	1000	16.8	3730	13.8	1.22
77	21	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	3.27e-06	3.29e-08	3470	58.1	14600	54	1.08
78	14	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	3.71e-06	3.68e-08	1360	22.7	5220	19.4	1.17
79	30	MA1545.1	OVOL2	MA1545.1	DDACCGTTABNYN	OVOL2	4.39e-06	4.31e-08	931	15.6	3440	12.8	1.22
80	26	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	5.33e-06	5.16e-08	4160	69.7	17800	65.9	1.06
81	31	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	7.46e-06	7.13e-08	1720	28.8	6820	25.3	1.14
82	32	MA0067.2	PAX2	MA0067.2	BCAVTSRAGCGTGACGR	PAX2	1.04e-05	9.81e-08	1910	32	7650	28.4	1.13
83	26	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	1.15e-05	1.07e-07	3440	57.6	14500	53.6	1.07
84	33	MA0615.1	Gmeb1	MA0615.1	BHBBKKACGTMMNWNNN	Gmeb1	1.96e-05	1.81e-07	1810	30.4	7240	26.9	1.13
85	25	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	3.39e-05	3.09e-07	275	4.61	850	3.15	1.47
86	34	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	3.54e-05	3.19e-07	1820	30.4	7280	27	1.13
87	20	MA1578.1	VEZF1	MA1578.1	CCCCCCMYDH	VEZF1	4.05e-05	3.61e-07	4540	76.1	19600	72.8	1.05
88	26	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	4.31e-05	3.79e-07	4700	78.8	20400	75.6	1.04
89	25	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	4.93e-05	4.29e-07	429	7.19	1450	5.37	1.34
90	25	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	5.23e-05	4.5e-07	446	7.48	1520	5.62	1.33
91	35	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	7.09e-05	6.04e-07	5000	83.8	21800	81	1.04
92	26	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	7.49e-05	6.31e-07	2800	47	11700	43.2	1.09
93	36	MA0751.1	ZIC4	MA0751.1	GRCCCCCCGCKGYGH	ZIC4	8.51e-05	7.09e-07	4110	68.9	17600	65.4	1.05
94	34	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	0.00014	1.15e-06	2320	38.8	9520	35.3	1.1
95	27	MA0815.1	TFAP2C	MA0815.1	TGCCCYSRGGGCA	TFAP2C	0.000156	1.27e-06	1580	26.5	6300	23.4	1.13
96	25	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	0.000168	1.36e-06	647	10.8	2350	8.71	1.25
97	33	MA0604.1	Atf1	MA0604.1	RTGACGTA	Atf1	0.000192	1.53e-06	2270	38	9320	34.5	1.1
98	25	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	0.000195	1.54e-06	163	2.73	457	1.69	1.62
99	34	MA0259.1	ARNT::HIF1A	MA0259.1	VBACGTGC	ARNT::HIF1A	2e-04	1.57e-06	1860	31.3	7540	28	1.12
100	27	MA0813.1	TFAP2B	MA0813.1	TGCCCYBRGGGCA	TFAP2B	0.000229	1.77e-06	1700	28.5	6840	25.4	1.13
101	37	MA0705.1	Lhx8	MA0705.1	CTAATTAV	Lhx8	0.000279	2.14e-06	902	15.1	3420	12.7	1.19
102	25	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	0.000287	2.17e-06	405	6.79	1380	5.12	1.33
103	34	MA1464.1	ARNT2	MA1464.1	GTCACGTGMN	ARNT2	0.000289	2.17e-06	1890	31.7	7670	28.4	1.11
104	38	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	0.00044	3.28e-06	3940	66	16900	62.6	1.05
105	25	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	0.000881	6.5e-06	246	4.12	780	2.89	1.43
106	34	MA0616.2	HES2	MA0616.2	GGCACGTGYC	HES2	0.00127	9.26e-06	2200	36.8	9060	33.6	1.1
107	21	MA1727.1	ZNF417	MA1727.1	VRBVNTGGGCGCCAM	ZNF417	0.00134	9.69e-06	3340	56	14200	52.7	1.06
108	33	MA1475.1	CREB3L4	MA1475.1	GRTGACGTCAYC	CREB3L4	0.00174	1.25e-05	3090	51.8	13100	48.5	1.07
109	36	MA0736.1	GLIS2	MA0736.1	GACCCCCCGCRAMG	GLIS2	0.002	1.42e-05	1980	33.2	8120	30.1	1.1
110	19	MA0750.2	ZBTB7A	MA0750.2	NVCCGGAAGTGSV	ZBTB7A	0.00214	1.51e-05	375	6.29	1300	4.81	1.31
111	21	MA0864.2	E2F2	MA0864.2	RWTTTGGCGCCAWWWY	E2F2	0.00317	2.21e-05	2030	34	8360	31	1.1
112	19	MA0028.2	ELK1	MA0028.2	ACCGGAAGTR	ELK1	0.00372	2.58e-05	296	4.96	993	3.68	1.35
113	25	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	0.00395	2.71e-05	178	2.98	542	2.01	1.49
114	23	MA1099.2	HES1	MA1099.2	GGCRCGTGBC	HES1	0.00487	3.31e-05	2450	41.1	10300	38.1	1.08
115	25	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	0.00682	4.59e-05	127	2.13	361	1.34	1.6
116	39	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	0.00833	5.56e-05	3160	52.9	13400	49.8	1.06
117	19	MA0156.3	FEV	MA0156.3	VACCGGAAGTVV	FEV	0.0095	6.29e-05	995	16.7	3910	14.5	1.15
118	40	MA0506.2 (Nrf1)	STREME-5	5-GCATGCACAC	GCATGCACAC	Nrf1	0.0116	7.64e-05	18	0.3	18	0.07	4.52
119	32	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	0.02	0.000131	618	10.4	2340	8.66	1.2
120	19	MA1484.1	ETS2	MA1484.1	DACCGGAAGY	ETS2	0.0208	0.000134	264	4.43	894	3.31	1.34
121	7	MA1656.1	ZNF449	MA1656.1	NNAAGCCCAACCNN	ZNF449	0.0281	0.00018	4370	73.2	19000	70.6	1.04
122	41	MA1951.1	FOS	MA1951.1	BGATGACGTCATCR	FOS	0.032	0.000204	347	5.82	1230	4.57	1.28
123	19	MA0475.2	FLI1	MA0475.2	ACCGGAARTR	FLI1	0.0338	0.000213	158	2.65	492	1.82	1.46
124	37	MA1495.1	HOXA1	MA1495.1	STAATTAS	HOXA1	0.0419	0.000262	2900	48.7	12400	45.9	1.06
125	41	MA0840.1	Creb5	MA0840.1	NATGACGTCAYH	Creb5	0.0462	0.000286	56	0.94	131	0.49	1.95
126	36	MA1584.1	ZIC5	MA1584.1	VGACCCCCCGCTGHGM	ZIC5	0.0488	3e-04	1490	25	6110	22.6	1.1
14	42	MA1107.2 (KLF9)	MEME-3	TGTGTGTGYGTGTGT	TGTGTGTGYGTGTGT	KLF9	4.06	0.29	141	2.36	600	2.22	1.07
15	43	MA1125.1 (ZNF384)	MEME-2	AAAAWRAAAAAAAAA	AAAAWRAAAAAAAAA	ZNF384	15	1	0	0	8	0.03	0.502

ER_rat <- 1.25

MTX_242kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("MTX_242kb_combo response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

MTX_242kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y, TP.)%>%
  arrange(.,EVALUE.y) %>%
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*4), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( "MTX_24 2kb response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

MTX_DAR 24 20kb data

MTX_24_20kb_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_24_20kb_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
MTX_24_20kb_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_24_20kb_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
MTX_24_20kb_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_24_20kb_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
MTX_24_20kb_sea_all <- rbind(MTX_24_20kb_sea_disc, MTX_24_20kb_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

MTX_24_20kb_combo <- MTX_24_20kb_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., MTX_24_20kb_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

MTX_24_20kb_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in MTX  v VEH") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in MTX v VEH
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA1513.1 (KLF15)	STREME-1	1-GCCCCGCCC	GCCCCGCCC	KLF15	8.57e-69	5.97e-69	1450	10.4	4390	6.02	1.73
2	2	MA0060.3 (NFYA)	STREME-3	3-CYGATTGGYYRSN	CYGATTGGYYRSN	NFYA	2.14e-56	7.46e-57	1030	7.45	2980	4.09	1.82
3	1	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	6.53e-55	1.52e-55	2080	15	7400	10.2	1.47
4	3	9-CCGVSBCGG	STREME-9	9-CCGVSBCGG	CCGVSBCGG	CCGVSBCGG	1.53e-52	2.67e-53	2950	21.2	11400	15.7	1.35
5	4	MA0079.5 (SP1)	MEME-3	CSCCGCCSCSSCCSC	CSCCGCCSCSSCCSC	SP1	6.19e-52	8.63e-53	2720	19.6	10400	14.2	1.37
6	1	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	8.57e-51	9.96e-52	1630	11.7	5550	7.61	1.54
7	2	MA0502.2	NFYB	MA0502.2	CYCATTGGCCVV	NFYB	1.05e-49	1.04e-50	943	6.79	2740	3.76	1.81
8	1	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	1.39e-46	1.21e-47	3150	22.7	12600	17.3	1.31
9	1	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	1.83e-46	1.42e-47	1110	7.98	3470	4.76	1.68
10	1	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	2.38e-46	1.66e-47	1860	13.4	6710	9.21	1.46
11	5	MA0733.1 (EGR4)	STREME-4	4-CCGCCCGCG	CCGCCCGCG	EGR4	1.11e-45	7.01e-47	3160	22.8	12700	17.4	1.31
12	6	MA0476.1 (FOS)	STREME-2	2-GATGASTCA	GATGASTCA	FOS	8.95e-45	5.2e-46	1570	11.3	5480	7.52	1.51
13	6	MA1128.1	FOSL1::JUN	MA1128.1	NKATGACTCATNN	FOSL1::JUN	1.46e-44	7.83e-46	1820	13.1	6580	9.03	1.46
14	6	MA0477.2	FOSL1	MA0477.2	NNATGACTCATNN	FOSL1	4.16e-44	2.07e-45	1810	13	6530	8.96	1.46
15	6	MA1928.1	BNC2	MA1928.1	NDRTGAGTCABN	BNC2	1.52e-43	7.06e-45	2060	14.9	7680	10.6	1.41
16	1	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	3.3e-43	1.44e-44	2020	14.6	7520	10.3	1.41
17	6	MA0099.3	FOS::JUN	MA0099.3	ATGAGTCAYM	FOS::JUN	5e-43	2.05e-44	1680	12.1	5990	8.22	1.47
18	6	MA1633.2	BACH1	MA1633.2	ATGACTCAT	BACH1	6.87e-42	2.66e-43	2650	19.1	10500	14.3	1.33
19	6	MA1141.1	FOS::JUND	MA1141.1	NKATGAGTCATNN	FOS::JUND	9.53e-42	3.5e-43	1710	12.3	6140	8.43	1.46
20	6	MA1137.1	FOSL1::JUNB	MA1137.1	NDRTGACTCATNN	FOSL1::JUNB	6.5e-41	2.27e-42	2740	19.7	10900	14.9	1.32
21	6	MA1135.1	FOSB::JUNB	MA1135.1	KRTGASTCAT	FOSB::JUNB	7.56e-41	2.51e-42	1760	12.7	6400	8.79	1.44
22	1	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	9.17e-40	2.91e-41	1180	8.52	3930	5.39	1.58
23	1	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	1.22e-39	3.69e-41	3330	24	13700	18.8	1.27
24	1	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	1.78e-39	5.16e-41	1470	10.6	5150	7.07	1.49
25	1	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	3.3e-39	9.2e-41	986	7.1	3120	4.28	1.66
26	6	MA0491.2	JUND	MA0491.2	NNATGACTCATNN	JUND	3.59e-39	9.64e-41	2700	19.4	10800	14.8	1.32
27	6	MA0462.2	BATF::JUN	MA0462.2	DATGACTCATH	BATF::JUN	9.37e-39	2.42e-40	2170	15.6	8310	11.4	1.37
28	6	MA1634.1	BATF	MA1634.1	DATGACTCATH	BATF	3.32e-37	8.06e-39	2100	15.2	8080	11.1	1.37
29	6	MA0478.1	FOSL2	MA0478.1	KRRTGASTCAB	FOSL2	3.35e-37	8.06e-39	1610	11.6	5830	8.01	1.45
30	6	MA1130.1	FOSL2::JUN	MA1130.1	NNRTGAGTCAYN	FOSL2::JUN	5.03e-37	1.17e-38	1490	10.7	5340	7.32	1.47
31	6	MA0835.2	BATF3	MA0835.2	DATGACTCATH	BATF3	8.8e-37	1.98e-38	2070	14.9	7950	10.9	1.37
32	1	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	2.5e-36	5.45e-38	2900	20.9	11800	16.2	1.29
33	1	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	3.84e-36	8.11e-38	1110	8	3720	5.1	1.57
34	7	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	2.06e-35	4.23e-37	3090	22.3	12800	17.6	1.27
35	6	MA1132.1	JUN::JUNB	MA1132.1	KATGACKCAT	JUN::JUNB	8.32e-35	1.66e-36	2560	18.4	10300	14.1	1.31
36	8	MA1982.1 (ZNF574)	STREME-5	5-SGGCCS	SGGCCS	ZNF574	1.16e-34	2.24e-36	3100	22.3	12800	17.6	1.27
37	2	MA0060.3	NFYA	MA0060.3	RRCCAATCAGM	NFYA	4.31e-34	8.12e-36	490	3.53	1270	1.74	2.03
38	6	MA0490.2	JUNB	MA0490.2	NNATGACTCATNN	JUNB	4.4e-33	8.06e-35	2830	20.4	11600	16	1.28
39	1	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	6.74e-33	1.21e-34	5160	37.1	23100	31.7	1.17
40	9	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	1.2e-32	2.09e-34	3400	24.5	14400	19.7	1.24
41	7	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	1.81e-32	3.07e-34	2330	16.8	9300	12.8	1.31
42	6	MA1101.2	BACH2	MA1101.2	DWANCATGASTCATSNTWH	BACH2	3.56e-32	5.91e-34	2580	18.6	10500	14.4	1.29
43	1	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	5.09e-32	8.25e-34	692	4.98	2080	2.86	1.75
44	10	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	1.14e-31	1.8e-33	4140	29.8	18100	24.8	1.2
45	11	14-MGGSCCK	STREME-14	14-MGGSCCK	14-MGGSCCK	MGGSCCK	2.45e-31	3.8e-33	8030	57.8	38000	52.2	1.11
46	6	MA0476.1	FOS	MA0476.1	DVTGASTCATB	FOS	3.57e-31	5.41e-33	1110	7.99	3840	5.27	1.52
47	2	MA1644.1	NFYC	MA1644.1	RDCCAATCASN	NFYC	1.84e-30	2.73e-32	566	4.08	1620	2.22	1.84
48	1	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	3.49e-30	5.07e-32	1960	14.1	7700	10.6	1.34
49	12	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	1.76e-29	2.5e-31	5370	38.7	24400	33.4	1.16
50	13	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	1.84e-29	2.56e-31	6220	44.8	28700	39.4	1.14
51	10	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	1.01e-28	1.39e-30	5580	40.2	25500	34.9	1.15
52	14	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	1.28e-28	1.72e-30	4810	34.6	21600	29.6	1.17
53	1	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	1.09e-27	1.43e-29	2320	16.7	9450	13	1.29
54	2	MA0502.2 (NFYB)	STREME-8	8-CCATTGGC	CCATTGGC	NFYB	1.32e-27	1.71e-29	371	2.67	929	1.27	2.1
55	15	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	6.84e-27	8.67e-29	5850	42.1	27000	37	1.14
56	1	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	1.16e-26	1.44e-28	528	3.8	1540	2.11	1.81
57	6	MA0489.2	Jun	MA0489.2	NVTGACTCATNN	Jun	3.53e-26	4.31e-28	1020	7.35	3590	4.93	1.49
58	16	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	1.51e-24	1.81e-26	4380	31.6	19700	27	1.17
59	4	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	2.01e-24	2.38e-26	2520	18.1	10500	14.5	1.25
60	10	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	2.4e-24	2.79e-26	3440	24.7	15000	20.6	1.2
61	1	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	4.95e-24	5.66e-26	6640	47.8	31300	42.9	1.11
62	10	MA0732.1	EGR3	MA0732.1	HHMCGCCCACGCAHH	EGR3	9.87e-24	1.11e-25	2620	18.9	11100	15.2	1.24
63	17	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	2.57e-23	2.85e-25	2580	18.6	10900	15	1.24
64	10	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	2.67e-23	2.91e-25	2730	19.7	11700	16	1.23
65	6	MA1142.1	FOSL1::JUND	MA1142.1	NRTGACTCAT	FOSL1::JUND	7.05e-23	7.56e-25	1160	8.32	4290	5.88	1.41
66	18	13-CACCSCG	STREME-13	13-CACCSCG	13-CACCSCG	CACCSCG	1.27e-22	1.34e-24	1780	12.8	7130	9.78	1.31
67	19	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	2.85e-22	2.96e-24	6880	49.5	32600	44.8	1.11
68	1	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	6.95e-22	7.12e-24	1580	11.4	6270	8.61	1.33
69	10	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	1.59e-21	1.6e-23	2010	14.5	8290	11.4	1.27
70	20	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	2.04e-20	2.03e-22	1200	8.67	4590	6.3	1.38
71	1	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	3.93e-20	3.86e-22	1500	10.8	5940	8.15	1.32
72	9	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	1.67e-19	1.62e-21	4420	31.9	20200	27.8	1.15
73	21	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	1.92e-19	1.84e-21	3690	26.6	16600	22.7	1.17
74	1	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	6.54e-19	6.16e-21	5250	37.8	24500	33.6	1.13
75	22	MA0774.1 (MEIS2)	STREME-12	12-CCTGTCAGC	12-CCTGTCAGC	MEIS2	1.01e-18	9.42e-21	1340	9.62	5260	7.22	1.33
76	23	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	1.04e-18	9.5e-21	973	7.01	3620	4.96	1.41
77	6	MA1144.1	FOSL2::JUND	MA1144.1	KATGACTCAT	FOSL2::JUND	5.78e-18	5.23e-20	743	5.35	2630	3.61	1.48
78	6	MA0841.1	NFE2	MA0841.1	VATGACTCATS	NFE2	9.31e-18	8.32e-20	763	5.49	2720	3.74	1.47
79	24	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	8.3e-17	7.32e-19	2650	19.1	11600	15.9	1.2
80	9	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	8.52e-17	7.42e-19	3190	23	14300	19.6	1.17
81	25	MA1573.2 (Thap11)	STREME-6	6-ACTACAACTCCC	ACTACAACTCCC	Thap11	9.98e-17	8.59e-19	53	0.38	39	0.05	7.08
82	6	MA1138.1	FOSL2::JUNB	MA1138.1	KRTGASTCAT	FOSL2::JUNB	3.59e-16	3.05e-18	700	5.04	2500	3.43	1.47
83	6	MA0496.3	MAFK	MA0496.3	NGMTGACTCAGCMNH	MAFK	4.56e-16	3.83e-18	2250	16.2	9710	13.3	1.22
84	6	MA0655.1	JDP2	MA0655.1	ATGACTCAT	JDP2	4.81e-16	3.99e-18	720	5.19	2590	3.55	1.46
85	6	MA0089.2	MAFG::NFE2L1	MA0089.2	NVNATGACTCAGCADW	MAFG::NFE2L1	5.45e-16	4.47e-18	2100	15.2	9020	12.4	1.23
86	26	MA1985.1	ZNF669	MA1985.1	GGGGYGAYGACCRCT	ZNF669	5.6e-16	4.54e-18	5410	39	25500	35	1.11
87	27	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	1.14e-15	9.15e-18	7150	51.5	34600	47.5	1.09
88	28	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	7.64e-15	6.05e-17	2000	14.4	8570	11.8	1.22
89	29	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	1.48e-14	1.16e-16	6540	47.1	31500	43.2	1.09
90	29	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	2.83e-14	2.19e-16	6440	46.3	31000	42.5	1.09
91	23	MA1099.2	HES1	MA1099.2	GGCRCGTGBC	HES1	8.93e-14	6.84e-16	1050	7.56	4150	5.7	1.33
92	29	MA0872.1	TFAP2A	MA0872.1	TGCCCYSRGGGCA	TFAP2A	2.79e-13	2.11e-15	3770	27.2	17400	23.9	1.14
93	1	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	2.81e-13	2.11e-15	713	5.13	2650	3.63	1.41
94	29	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	3.31e-13	2.45e-15	6060	43.7	29100	40	1.09
95	30	MA0464.2	BHLHE40	MA0464.2	VKCACGTGMC	BHLHE40	8.66e-13	6.36e-15	5240	37.7	24900	34.2	1.1
96	25	MA1573.2	Thap11	MA1573.2	ACTACAABTCCCAG	Thap11	3.46e-12	2.52e-14	196	1.41	516	0.71	2
97	6	MA0501.1	MAF::NFE2	MA0501.1	ATGACTCAGCANWTY	MAF::NFE2	4.34e-12	3.12e-14	1750	12.6	7520	10.3	1.22
98	31	10-ACATGCACACACGT	STREME-10	10-ACATGCACACACGT	10-ACATGCACACACGT	ACATGCACACACGT	4.92e-12	3.5e-14	102	0.73	194	0.27	2.77
99	32	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	7.58e-12	5.34e-14	3450	24.9	15900	21.9	1.14
100	6	MA1134.1	FOS::JUNB	MA1134.1	KATGASTCATHN	FOS::JUNB	8.03e-12	5.6e-14	483	3.48	1690	2.32	1.5
101	29	MA0813.1	TFAP2B	MA0813.1	TGCCCYBRGGGCA	TFAP2B	8.33e-12	5.75e-14	3280	23.6	15100	20.7	1.14
102	33	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	1e-11	6.84e-14	832	5.99	3240	4.45	1.35
103	34	MA1108.2 (MXI1)	STREME-11	11-ACACACATGTGCA	11-ACACACATGTGCA	MXI1	1.48e-11	1e-13	80	0.58	132	0.18	3.2
104	35	MA1643.1	NFIB	MA1643.1	NNCCTGGCAYNGTGCCAAGNN	NFIB	2.69e-11	1.81e-13	4960	35.7	23600	32.4	1.1
105	6	MA1988.1	Atf3	MA1988.1	NRTGACTCABN	Atf3	4.23e-11	2.81e-13	495	3.56	1760	2.42	1.48
106	10	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	5.31e-11	3.49e-13	12100	87.2	61800	84.8	1.03
107	6	MA0659.3	Mafg	MA0659.3	NWGMTGACTCAGCAN	Mafg	1.66e-10	1.08e-12	4810	34.6	22900	31.5	1.1
108	29	MA0815.1	TFAP2C	MA0815.1	TGCCCYSRGGGCA	TFAP2C	9.26e-10	5.98e-12	1510	10.9	6520	8.95	1.22
109	15	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	1.25e-09	8.02e-12	8700	62.7	43400	59.5	1.05
110	36	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	1.61e-09	1.02e-11	4900	35.3	23500	32.2	1.09
111	30	MA0616.2	HES2	MA0616.2	GGCACGTGYC	HES2	2.27e-09	1.42e-11	1170	8.43	4920	6.75	1.25
112	15	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	2.68e-09	1.67e-11	11800	85.2	60400	82.9	1.03
113	6	MA1114.1	PBX3	MA1114.1	NNNTGAGTGACAGGBNN	PBX3	2.71e-09	1.67e-11	9400	67.7	47100	64.7	1.05
114	30	MA0608.1	Creb3l2	MA0608.1	GCCACGTGD	Creb3l2	2.99e-09	1.83e-11	4460	32.2	21300	29.2	1.1
115	30	MA1631.1	ASCL1	MA1631.1	NNGCACCTGCYNB	ASCL1	3.33e-09	2.02e-11	11400	82.3	58200	79.8	1.03
116	31	MA1155.1 (ZSCAN4)	STREME-7	7-GTGTGTGCATGYGTG	GTGTGTGCATGYGTG	ZSCAN4	3.5e-09	2.1e-11	96	0.69	203	0.28	2.49
117	37	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	8.06e-09	4.8e-11	9050	65.2	45300	62.2	1.05
118	10	MA1656.1	ZNF449	MA1656.1	NNAAGCCCAACCNN	ZNF449	1.7e-08	1e-10	7680	55.3	38100	52.3	1.06
119	27	MA1719.1	ZNF816	MA1719.1	DRRKGGGGACATGCHGGG	ZNF816	3.43e-08	2.01e-10	8540	61.5	42700	58.6	1.05
120	15	MA1569.1	TFAP2E	MA1569.1	YGCCYSRGGCD	TFAP2E	3.83e-08	2.22e-10	1020	7.37	4300	5.9	1.25
121	30	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	4.89e-08	2.82e-10	10700	76.8	54100	74.2	1.03
122	38	MA1557.1	SMAD5	MA1557.1	YGTCTAGACA	SMAD5	5.21e-08	2.98e-10	4150	29.9	19800	27.2	1.1
123	22	MA0774.1	MEIS2	MA0774.1	TTGACAGS	MEIS2	7.56e-08	4.29e-10	2670	19.2	12400	17	1.13
124	39	MA0864.2	E2F2	MA0864.2	RWTTTGGCGCCAWWWY	E2F2	8.03e-08	4.51e-10	4360	31.4	20900	28.7	1.09
125	40	MA1966.1	TFAP4::ETV1	MA1966.1	RSCGGAAGCAGSTGKN	TFAP4::ETV1	9.07e-08	5.06e-10	6280	45.2	30800	42.3	1.07
126	40	MA0076.2	ELK4	MA0076.2	BCRCTTCCGGB	ELK4	9.93e-08	5.49e-10	367	2.64	1310	1.8	1.47
127	7	MA0528.2	ZNF263	MA0528.2	VNGGGGAGGASG	ZNF263	5.17e-07	2.84e-09	7320	52.8	36400	49.9	1.06
128	30	MA0649.1	HEY2	MA0649.1	GRCACGTGYC	HEY2	5.95e-07	3.24e-09	3550	25.6	16900	23.2	1.1
129	30	MA0147.3	MYC	MA0147.3	NNCCACGTGCNB	MYC	6.28e-07	3.4e-09	11100	80.1	56700	77.8	1.03
130	24	MA0067.2	PAX2	MA0067.2	BCAVTSRAGCGTGACGR	PAX2	7.94e-07	4.26e-09	4330	31.2	20900	28.7	1.09
131	41	MA0767.1	GCM2	MA0767.1	BATGCGGGTR	GCM2	8.71e-07	4.6e-09	5700	41	27900	38.3	1.07
132	39	MA1727.1	ZNF417	MA1727.1	VRBVNTGGGCGCCAM	ZNF417	8.71e-07	4.6e-09	3370	24.3	16000	21.9	1.11
133	30	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	9.4e-07	4.93e-09	722	5.2	2950	4.05	1.29
134	40	MA0764.3	ETV4	MA0764.3	ACCGGAAGTR	ETV4	1.06e-06	5.53e-09	246	1.77	822	1.13	1.57
135	30	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	1.37e-06	7.08e-09	1290	9.28	5650	7.76	1.2
136	30	MA0603.1	Arntl	MA0603.1	NGTCACGTGH	Arntl	1.53e-06	7.85e-09	10500	75.8	53500	73.4	1.03
137	42	MA1964.1	SMAD2	MA1964.1	NBCCAGACDN	SMAD2	1.57e-06	8e-09	9780	70.4	49500	67.9	1.04
138	30	MA1106.1	HIF1A	MA1106.1	SBACGTGCNN	HIF1A	4.05e-06	2.05e-08	3140	22.6	14900	20.4	1.11
139	30	MA1464.1	ARNT2	MA1464.1	GTCACGTGMN	ARNT2	5.25e-06	2.63e-08	3400	24.5	16200	22.3	1.1
140	43	MA1684.1	Foxn1	MA1684.1	RGAMGC	Foxn1	5.72e-06	2.85e-08	2230	16	10300	14.2	1.13
141	30	MA1474.1	CREB3L4	MA1474.1	YGCCACGTCAYC	CREB3L4	5.99e-06	2.96e-08	9250	66.6	46700	64.1	1.04
142	7	MA1578.1	VEZF1	MA1578.1	CCCCCCMYDH	VEZF1	8.96e-06	4.4e-08	1960	14.2	9030	12.4	1.14
143	44	MA0028.2	ELK1	MA0028.2	ACCGGAAGTR	ELK1	1.13e-05	5.51e-08	182	1.31	582	0.8	1.65
144	39	MA0024.3	E2F1	MA0024.3	TTTGGCGCCAAA	E2F1	1.15e-05	5.57e-08	3240	23.3	15400	21.2	1.1
145	6	MA1521.1	MAFA	MA1521.1	NTGCTGASTCAGCAN	MAFA	1.17e-05	5.6e-08	4410	31.7	21400	29.4	1.08
146	24	MA1995.1	Npas4	MA1995.1	NNTCGTGACHN	Npas4	2.58e-05	1.23e-07	4500	32.4	21900	30	1.08
147	44	MA0765.3	ETV5	MA0765.3	ACCGGAAGTR	ETV5	2.96e-05	1.4e-07	184	1.33	600	0.82	1.62
148	45	MA1710.1	ZNF257	MA1710.1	VDGAGGCRAGRG	ZNF257	4.4e-05	2.07e-07	4500	32.4	21900	30.1	1.08
149	46	MA0597.2	THAP1	MA0597.2	VSGCAGGGCASV	THAP1	5.45e-05	2.55e-07	10100	72.9	51500	70.7	1.03
150	39	MA0470.2	E2F4	MA0470.2	TTTTGGCGCCAWWW	E2F4	9.12e-05	4.24e-07	1950	14	9050	12.4	1.13
151	1	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	9.28e-05	4.29e-07	144	1.04	448	0.61	1.69
152	30	MA0822.1	HES7	MA0822.1	YGGCACGTGCCR	HES7	0.000115	5.28e-07	793	5.71	3400	4.66	1.23
153	40	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	0.000141	6.41e-07	4020	28.9	19500	26.8	1.08
154	44	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	0.000166	7.51e-07	186	1.34	627	0.86	1.56
155	40	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	0.00023	1.03e-06	7730	55.7	38900	53.4	1.04
156	30	MA0844.1	XBP1	MA0844.1	WDKGMCACGTCATC	XBP1	0.000261	1.17e-06	4620	33.2	22700	31.1	1.07
157	30	MA1934.1	ERF::FIGLA	MA1934.1	RCCGGAARCASCTGBN	ERF::FIGLA	0.000309	1.37e-06	2770	20	13200	18.2	1.1
158	37	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	0.000352	1.55e-06	5140	37	25400	34.8	1.06
159	47	MA1982.1	ZNF574	MA1982.1	VGSCTAGAGMGGCCS	ZNF574	0.000374	1.64e-06	7150	51.5	35800	49.2	1.05
160	40	MA1941.1	ETV2::FIGLA	MA1941.1	RSCGGAARCAGSTGBN	ETV2::FIGLA	0.000419	1.82e-06	5860	42.2	29100	40	1.06
161	48	MA1730.1	ZNF708	MA1730.1	NNRGCTGTRCCTCCY	ZNF708	0.000426	1.85e-06	7290	52.5	36600	50.2	1.05
162	22	MA0775.1	MEIS3	MA0775.1	DTGACAGS	MEIS3	0.000489	2.1e-06	6010	43.3	29900	41.1	1.05
163	30	MA0692.1	TFEB	MA0692.1	RYCACGTGAC	TFEB	0.000506	2.16e-06	11700	84.2	60100	82.5	1.02
164	6	MA0782.2	PKNOX1	MA0782.2	NNTGAGTGACAGVNN	PKNOX1	0.000525	2.23e-06	9390	67.6	47700	65.5	1.03
165	39	MA0615.1	Gmeb1	MA0615.1	BHBBKKACGTMMNWNNN	Gmeb1	0.000681	2.88e-06	635	4.57	2690	3.7	1.24
166	22	MA0498.2	MEIS1	MA0498.2	HTGACAD	MEIS1	0.000717	3.01e-06	7520	54.1	37800	51.9	1.04
167	30	MA1493.1	HES6	MA1493.1	GGCACGTGTY	HES6	0.000745	3.11e-06	3580	25.8	17400	23.9	1.08
168	30	MA1560.1	SOHLH2	MA1560.1	YGCACGTGCN	SOHLH2	0.000797	3.31e-06	269	1.94	1010	1.38	1.41
169	30	MA0004.1	Arnt	MA0004.1	CACGTG	Arnt	0.000897	3.7e-06	2180	15.7	10300	14.2	1.11
170	27	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	0.00121	4.98e-06	6740	48.5	33800	46.4	1.05
171	30	MA0499.2	MYOD1	MA0499.2	NNGCACCTGTCNB	MYOD1	0.00126	5.15e-06	11300	81.6	58200	79.9	1.02
172	37	MA0695.1	ZBTB7C	MA0695.1	RCGACCACCGAN	ZBTB7C	0.00181	7.32e-06	1550	11.2	7180	9.85	1.13
173	44	MA1933.1	ELK1::SREBF2	MA1933.1	DCCGGAAGTSRCGTGA	ELK1::SREBF2	0.00246	9.92e-06	2010	14.5	9510	13	1.11
174	40	MA0763.1	ETV3	MA0763.1	ACCGGAAGTR	ETV3	0.00277	1.11e-05	239	1.72	893	1.23	1.41
175	44	MA0156.3	FEV	MA0156.3	VACCGGAAGTVV	FEV	0.00285	1.13e-05	238	1.71	889	1.22	1.41
176	49	MA0155.1	INSM1	MA0155.1	TGYCWGGGGGCR	INSM1	0.00321	1.27e-05	2430	17.5	11600	15.9	1.1
177	37	MA0694.1	ZBTB7B	MA0694.1	RCGACCACCGAA	ZBTB7B	0.00518	2.04e-05	3320	23.9	16200	22.2	1.08
178	21	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	0.00551	2.16e-05	3830	27.6	18800	25.8	1.07
179	50	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	0.00557	2.17e-05	393	2.83	1610	2.2	1.29
180	21	MA0163.1	PLAG1	MA0163.1	GGGGCCCWAGGGGG	PLAG1	0.00771	2.99e-05	1360	9.82	6320	8.68	1.13
181	51	MA1584.1	ZIC5	MA1584.1	VGACCCCCCGCTGHGM	ZIC5	0.00788	3.03e-05	1420	10.2	6600	9.05	1.13
182	40	MA0645.1	ETV6	MA0645.1	MSCGGAAGTR	ETV6	0.0118	4.54e-05	151	1.09	529	0.73	1.5
183	15	MA1581.1	ZBTB6	MA1581.1	DNSCTTGAGCCNV	ZBTB6	0.0122	4.64e-05	4470	32.2	22100	30.4	1.06
184	40	MA1484.1	ETS2	MA1484.1	DACCGGAAGY	ETS2	0.0137	5.18e-05	215	1.55	811	1.11	1.4
185	30	MA0058.3	MAX	MA0058.3	AVCACGTGNY	MAX	0.0193	7.29e-05	8610	62	43800	60.1	1.03
186	52	MA0863.1	MTF1	MA0863.1	TTTGCACACGGCAC	MTF1	0.024	9.01e-05	1540	11	7220	9.91	1.12
187	15	MA1629.1	Zic2	MA1629.1	NDCACAGCAGGDRG	Zic2	0.0279	0.000104	12300	88.5	63600	87.3	1.01
188	30	MA0103.3	ZEB1	MA0103.3	SNCACCTGSVN	ZEB1	0.0279	0.000104	12500	90.3	65000	89.2	1.01
16	6	MA1633.2 (BACH1)	MEME-2	TGRCTCAYGCCTGTA	TGRCTCAYGCCTGTA	BACH1	15.4	0.961	168	1.21	959	1.32	0.924
17	53	MA1125.1 (ZNF384)	MEME-1	WAAAAAAAAAAAAAA	WAAAAAAAAAAAAAA	ZNF384	16.9	0.995	22	0.16	159	0.22	0.754
18	54	MA0114.4 (HNF4A)	MEME-4	CCAAAGTGCTGGGAT	CCAAAGTGCTGGGAT	HNF4A	18	1	542	3.9	3360	4.62	0.846

ER_rat <- 1.25

MTX_24_20kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("MTX_24_20kb_combo response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

MTX_24_20kb_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*9), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./9,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("MTX_24_20kb_combo response peaks(200bp)Enrichment ratio:",ER_rat))

Version	Author	Date
53f3fdc	reneeisnowhere	2025-07-01

DAR_DEG data FULL set

DOX 3 hour

DOX_3_DAR_DEG_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_3_DEG_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DOX_3_DAR_DEG_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_3_DEG_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DOX_3_DAR_DEG_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_3_DEG_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DOX_3_DAR_DEG_sea_all <- rbind(DOX_3_DAR_DEG_sea_disc, DOX_3_DAR_DEG_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DOX_3_DAR_DEG_combo <- DOX_3_DAR_DEG_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DOX_3_DAR_DEG_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

DOX_3_DAR_DEG_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in MTX  v VEH") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in MTX v VEH
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA0528.2 (ZNF263)	STREME-1	1-GAGCTGGGAGGAV	GAGCTGGGAGGAV	ZNF263	1.63e-08	1.23e-08	6	100	40	1.15	84.6
2	2	MA0697.2 (Zic3)	STREME-2	2-CAGCAGGBGCGB	CAGCAGGBGCGB	Zic3	2.63e-08	1.23e-08	5	83.3	11	0.32	248
3	3	MA0154.4 (EBF1)	STREME-3	3-CCCYCYAGGVGRRG	CCCYCYAGGVGRRG	EBF1	1.94e-05	6.02e-06	3	50	1	0.03	991
4	4	MA1629.1 (Zic2)	STREME-4	4-CCGGCYGGGAHT	CCGGCYGGGAHT	Zic2	7.27e-05	1.69e-05	3	50	2	0.06	661
5	5	MA1615.1 (Plagl1)	STREME-5	5-CTGGCCGCCG	CTGGCCGCCG	Plagl1	0.000124	2.31e-05	4	66.7	22	0.63	108

ER_rat <- 1.25

DOX_3_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DOX_3_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

DOX_3_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*.05), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.05,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DOX_3_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

DOX 24 hour

DOX_24_DAR_DEG_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_DEG_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DOX_24_DAR_DEG_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_DEG_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DOX_24_DAR_DEG_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_24_DEG_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DOX_24_DAR_DEG_sea_all <- rbind(DOX_24_DAR_DEG_sea_disc, DOX_24_DAR_DEG_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DOX_24_DAR_DEG_combo <- DOX_24_DAR_DEG_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DOX_24_DAR_DEG_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

DOX_24_DAR_DEG_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in MTX  v VEH") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in MTX v VEH
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA0742.2 (KLF12)	STREME-2	2-CCCGYCCS	CCCGYCCS	KLF12	3.39e-32	2.56e-32	1890	11.4	3360	8.06	1.41
2	2	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	5.12e-30	1.93e-30	5110	30.8	10800	25.9	1.19
3	3	MA1973.1 (ZKSCAN3)	STREME-8	8-SCCCAGGCTGSSS	SCCCAGGCTGSSS	ZKSCAN3	2.86e-29	7.21e-30	6100	36.8	13200	31.7	1.16
4	4	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	3.44e-26	6.49e-27	2450	14.8	4740	11.4	1.3
5	5	MA1713.1 (ZNF610)	STREME-3	3-CCGCTCC	CCGCTCC	ZNF610	4.41e-26	6.66e-27	6030	36.3	13100	31.5	1.15
6	6	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	1.22e-24	1.54e-25	2510	15.1	4900	11.8	1.29
7	7	MA0732.1 (EGR3)	STREME-6	6-GGCGSW	GGCGSW	EGR3	1.11e-23	1.19e-24	3540	21.3	7300	17.5	1.22
8	6	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	1.11e-22	1.05e-23	2780	16.8	5580	13.4	1.25
9	8	MA1712.1 (ZNF454)	STREME-4	4-SGGSCCS	SGGSCCS	ZNF454	3.48e-22	2.92e-23	2880	17.4	5820	14	1.24
10	4	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	6.74e-22	5.09e-23	5070	30.5	11000	26.3	1.16
11	9	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	4.96e-21	3.4e-22	3700	22.3	7760	18.6	1.2
12	6	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	1.23e-20	7.77e-22	5610	33.8	12300	29.6	1.14
13	6	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	6.53e-20	3.79e-21	6330	38.1	14100	33.8	1.13
14	6	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	1.15e-19	6.22e-21	5050	30.4	11000	26.4	1.15
15	10	1-CCGGGCC	STREME-1	1-CCGGGCC	CCGGGCC	CCGGGCC	2.24e-19	1.13e-20	2480	14.9	4970	11.9	1.25
16	11	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	2.46e-19	1.16e-20	6530	39.4	14600	35.1	1.12
17	6	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	2.94e-19	1.3e-20	3100	18.6	6410	15.4	1.21
18	6	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	3.14e-19	1.3e-20	5420	32.6	11900	28.6	1.14
19	12	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	3.27e-19	1.3e-20	4120	24.8	8820	21.1	1.17
20	6	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	1.13e-18	4.28e-20	1810	10.9	3490	8.35	1.3
21	6	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	1.29e-18	4.65e-20	4430	26.7	9570	22.9	1.16
22	13	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	1.38e-18	4.73e-20	2430	14.6	4900	11.7	1.25
23	14	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	1.84e-18	5.73e-20	4270	25.7	9200	22	1.17
24	6	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	1.87e-18	5.73e-20	5010	30.2	11000	26.3	1.15
25	6	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	1.9e-18	5.73e-20	4130	24.9	8860	21.2	1.17
26	2	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	2.95e-18	8.28e-20	5610	33.8	12400	29.8	1.13
27	6	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	2.96e-18	8.28e-20	7490	45.1	17000	40.8	1.1
28	15	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	3.19e-18	8.62e-20	2590	15.6	5280	12.6	1.24
29	16	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	4.23e-17	1.07e-18	3850	23.2	8260	19.8	1.17
30	17	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	4.25e-17	1.07e-18	4660	28.1	10200	24.4	1.15
31	18	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	4.55e-17	1.11e-18	5850	35.2	13100	31.3	1.13
32	6	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	5.14e-17	1.21e-18	7360	44.3	16800	40.2	1.1
33	19	MA1596.1 (ZNF460)	STREME-5	5-GCSTCC	GCSTCC	ZNF460	7.3e-17	1.67e-18	5240	31.6	11600	27.8	1.14
34	20	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	3.69e-16	8.2e-18	3880	23.4	8360	20	1.17
35	12	MA0732.1	EGR3	MA0732.1	HHMCGCCCACGCAHH	EGR3	1.1e-15	2.37e-17	3010	18.1	6330	15.2	1.2
36	14	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	1.47e-15	3.08e-17	5430	32.7	12100	29	1.13
37	21	MA0024.3	E2F1	MA0024.3	TTTGGCGCCAAA	E2F1	2.8e-15	5.72e-17	3270	19.7	6940	16.6	1.18
38	22	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	3.79e-15	7.53e-17	1880	11.4	3750	8.99	1.26
39	11	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	5.42e-15	1.05e-16	7300	44	16700	40.1	1.1
40	6	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	6.16e-15	1.16e-16	1120	6.77	2070	4.95	1.37
41	15	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	6.49e-15	1.18e-16	3880	23.4	8410	20.2	1.16
42	6	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	6.58e-15	1.18e-16	2660	16	5540	13.3	1.21
43	23	MA0736.1	GLIS2	MA0736.1	GACCCCCCGCRAMG	GLIS2	6.73e-15	1.18e-16	5260	31.7	11700	28.1	1.13
44	11	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	1.04e-14	1.78e-16	5480	33	12300	29.4	1.12
45	6	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	1.59e-14	2.67e-16	2560	15.4	5310	12.7	1.21
46	15	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	1.83e-14	2.99e-16	1750	10.6	3470	8.32	1.27
47	6	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	1.86e-14	2.99e-16	7410	44.6	17000	40.8	1.09
48	6	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	3.36e-14	5.28e-16	1150	6.93	2140	5.13	1.35
49	6	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	5.18e-14	7.99e-16	4910	29.6	10900	26.2	1.13
50	11	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	9.27e-14	1.4e-15	7960	48	18500	44.2	1.09
51	6	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	3.96e-13	5.87e-15	1140	6.88	2150	5.14	1.34
52	23	MA0751.1	ZIC4	MA0751.1	GRCCCCCCGCKGYGH	ZIC4	5.64e-13	8.2e-15	5790	34.9	13100	31.4	1.11
53	24	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	1.4e-12	1.99e-14	2380	14.4	4970	11.9	1.2
54	6	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	1.49e-12	2.09e-14	2280	13.7	4730	11.3	1.21
55	25	MA1985.1	ZNF669	MA1985.1	GGGGYGAYGACCRCT	ZNF669	2.41e-12	3.3e-14	4390	26.4	9750	23.4	1.13
56	6	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	2.56e-12	3.46e-14	1780	10.7	3600	8.63	1.24
57	17	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	2.9e-12	3.85e-14	7060	42.5	16300	39	1.09
58	6	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	4.81e-12	6.27e-14	2180	13.2	4530	10.9	1.21
59	23	MA1578.1	VEZF1	MA1578.1	CCCCCCMYDH	VEZF1	5.09e-12	6.52e-14	8190	49.3	19100	45.8	1.08
60	26	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	7.75e-12	9.76e-14	2830	17.1	6060	14.5	1.18
61	12	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	8.27e-12	1.02e-13	7160	43.1	16600	39.7	1.09
62	27	MA1728.1	ZNF549	MA1728.1	NNTGCTGCCCWR	ZNF549	9.99e-12	1.22e-13	6990	42.1	16100	38.6	1.09
63	28	MA0694.1	ZBTB7B	MA0694.1	RCGACCACCGAA	ZBTB7B	1.49e-11	1.79e-13	6780	40.8	15600	37.5	1.09
64	12	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	1.8e-11	2.12e-13	3350	20.2	7300	17.5	1.15
65	29	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	2.38e-11	2.76e-13	8010	48.3	18700	44.8	1.08
66	30	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	2.71e-11	3.1e-13	4620	27.8	10300	24.8	1.12
67	31	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	3.32e-11	3.74e-13	3730	22.5	8220	19.7	1.14
68	12	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	4.3e-11	4.78e-13	12500	75	30000	72	1.04
69	32	MA1719.1	ZNF816	MA1719.1	DRRKGGGGACATGCHGGG	ZNF816	6.74e-11	7.38e-13	5070	30.5	11500	27.4	1.11
70	33	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	7.67e-11	8.27e-13	7510	45.2	17500	41.9	1.08
71	14	MA1581.1	ZBTB6	MA1581.1	DNSCTTGAGCCNV	ZBTB6	7.94e-10	8.44e-12	7930	47.7	18600	44.5	1.07
72	34	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	1.03e-09	1.08e-11	2600	15.6	5580	13.4	1.17
73	28	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	1.35e-09	1.4e-11	7540	45.4	17600	42.2	1.08
74	21	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	1.62e-09	1.66e-11	2440	14.7	5230	12.5	1.17
75	12	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	2.12e-09	2.14e-11	2100	12.6	4430	10.6	1.19
76	28	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	2.18e-09	2.17e-11	5010	30.2	11400	27.3	1.11
77	2	MA1587.1	ZNF135	MA1587.1	CCTCGACCTCCYRR	ZNF135	2.46e-09	2.41e-11	4000	24.1	8950	21.4	1.12
78	28	MA0695.1	ZBTB7C	MA0695.1	RCGACCACCGAN	ZBTB7C	1.02e-08	9.88e-11	11300	68.3	27300	65.4	1.04
79	35	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	2.26e-08	2.16e-10	7660	46.2	18000	43.2	1.07
80	35	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	3.19e-08	3.01e-10	3330	20.1	7400	17.7	1.13
81	21	MA0470.2	E2F4	MA0470.2	TTTTGGCGCCAWWW	E2F4	3.56e-08	3.32e-10	1660	10	3460	8.29	1.21
82	6	MA0528.2	ZNF263	MA0528.2	VNGGGGAGGASG	ZNF263	4.35e-08	4.01e-10	2730	16.4	5960	14.3	1.15
83	36	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	1.19e-07	1.08e-09	661	3.98	1220	2.93	1.36
84	35	MA0259.1	ARNT::HIF1A	MA0259.1	VBACGTGC	ARNT::HIF1A	1.21e-07	1.09e-09	3960	23.9	8950	21.4	1.11
85	11	MA1569.1	TFAP2E	MA1569.1	YGCCYSRGGCD	TFAP2E	1.53e-07	1.36e-09	1160	6.99	2340	5.6	1.25
86	35	MA1966.1	TFAP4::ETV1	MA1966.1	RSCGGAAGCAGSTGKN	TFAP4::ETV1	1.89e-07	1.66e-09	4960	29.9	11400	27.3	1.09
87	12	MA1656.1	ZNF449	MA1656.1	NNAAGCCCAACCNN	ZNF449	2.12e-07	1.84e-09	7400	44.6	17400	41.8	1.07
88	35	MA1106.1	HIF1A	MA1106.1	SBACGTGCNN	HIF1A	2.32e-07	2e-09	6620	39.9	15500	37.1	1.07
89	37	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	3.48e-07	2.95e-09	993	5.98	1970	4.72	1.27
90	21	MA0864.2	E2F2	MA0864.2	RWTTTGGCGCCAWWWY	E2F2	4.28e-07	3.59e-09	1280	7.74	2640	6.31	1.23
91	19	MA1684.1	Foxn1	MA1684.1	RGAMGC	Foxn1	4.35e-07	3.61e-09	715	4.31	1360	3.25	1.33
92	29	MA0006.1	Ahr::Arnt	MA0006.1	YGCGTG	Ahr::Arnt	4.78e-07	3.93e-09	2370	14.3	5180	12.4	1.15
93	38	MA1973.1	ZKSCAN3	MA1973.1	KDKCCCAGGCTAGCCCABNN	ZKSCAN3	5.07e-07	4.12e-09	3910	23.6	8870	21.2	1.11
94	35	MA0597.2	THAP1	MA0597.2	VSGCAGGGCASV	THAP1	6.89e-07	5.54e-09	3570	21.5	8040	19.3	1.12
95	39	MA0511.2	RUNX2	MA0511.2	WAACCGCAA	RUNX2	9.25e-07	7.36e-09	11600	70.1	28200	67.5	1.04
96	35	MA1945.1	ETV5::FIGLA	MA1945.1	RGCGGAARCAGGTGG	ETV5::FIGLA	1.05e-06	8.22e-09	6730	40.5	15800	37.9	1.07
97	35	MA1941.1	ETV2::FIGLA	MA1941.1	RSCGGAARCAGSTGBN	ETV2::FIGLA	1.06e-06	8.22e-09	9000	54.2	21500	51.5	1.05
98	30	MA0067.2	PAX2	MA0067.2	BCAVTSRAGCGTGACGR	PAX2	1.22e-06	9.4e-09	1190	7.16	2430	5.82	1.23
99	13	MA1930.1	CTCF	MA1930.1	CTGCAGTKCCNVCHNNYRGCCASYAGRKGGCRAKC	CTCF	1.44e-06	1.1e-08	3860	23.2	8770	21	1.11
100	23	MA1584.1	ZIC5	MA1584.1	VGACCCCCCGCTGHGM	ZIC5	2.53e-06	1.91e-08	2750	16.6	6120	14.6	1.13
101	40	MA0615.1	Gmeb1	MA0615.1	BHBBKKACGTMMNWNNN	Gmeb1	2.62e-06	1.96e-08	4180	25.1	9540	22.9	1.1
102	35	MA1631.1	ASCL1	MA1631.1	NNGCACCTGCYNB	ASCL1	2.84e-06	2.1e-08	1990	12	4300	10.3	1.16
103	35	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	2.89e-06	2.12e-08	10400	62.9	25200	60.3	1.04
104	21	MA1727.1	ZNF417	MA1727.1	VRBVNTGGGCGCCAM	ZNF417	4.81e-06	3.49e-08	2470	14.9	5450	13.1	1.14
105	41	MA1964.1	SMAD2	MA1964.1	NBCCAGACDN	SMAD2	5.09e-06	3.66e-08	7550	45.4	17900	42.8	1.06
106	42	MA1716.1	ZNF76	MA1716.1	NNTWCCCAYAATGCAHYGCGC	ZNF76	9.85e-06	7.02e-08	4730	28.5	10900	26.2	1.09
107	23	MA0696.1	ZIC1	MA0696.1	GACCCCCYGCTGTG	ZIC1	1.13e-05	7.98e-08	2620	15.8	5840	14	1.13
108	4	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	1.29e-05	9.06e-08	385	2.32	676	1.62	1.43
109	43	MA1982.1	ZNF574	MA1982.1	VGSCTAGAGMGGCCS	ZNF574	1.42e-05	9.87e-08	3120	18.8	7050	16.9	1.11
110	44	MA1710.1	ZNF257	MA1710.1	VDGAGGCRAGRG	ZNF257	1.49e-05	1.02e-07	10800	65.2	26200	62.8	1.04
111	45	MA0145.2	Tfcp2l1	MA0145.2	CCAGYYYVADCCRG	Tfcp2l1	1.66e-05	1.13e-07	5190	31.2	12100	28.9	1.08
112	46	MA0750.2	ZBTB7A	MA0750.2	NVCCGGAAGTGSV	ZBTB7A	1.84e-05	1.24e-07	1830	11	3960	9.5	1.16
113	47	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	3.07e-05	2.05e-07	11200	67.6	27300	65.3	1.04
114	11	MA0815.1	TFAP2C	MA0815.1	TGCCCYSRGGGCA	TFAP2C	3.46e-05	2.29e-07	2410	14.5	5350	12.8	1.13
115	11	MA0872.1	TFAP2A	MA0872.1	TGCCCYSRGGGCA	TFAP2A	4.15e-05	2.73e-07	2280	13.7	5040	12.1	1.14
116	48	MA1972.1	ZFP14	MA1972.1	GGAGGCHCHGGARBG	ZFP14	4.7e-05	3.06e-07	8510	51.2	20400	48.8	1.05
117	49	MA1542.1	OSR1	MA1542.1	HGCTACYGTD	OSR1	7.2e-05	4.65e-07	12300	73.8	29900	71.7	1.03
118	13	MA0155.1	INSM1	MA0155.1	TGYCWGGGGGCR	INSM1	8.36e-05	5.35e-07	3800	22.9	8720	20.9	1.09
119	13	MA1929.1	CTCF	MA1929.1	CTGCAGTKCCNNNNNYNRCCASYAGRKGGCRSWG	CTCF	1e-04	6.35e-07	2310	13.9	5130	12.3	1.13
120	50	MA1628.1	Zic1::Zic2	MA1628.1	CVCAGCAGGNV	Zic1::Zic2	0.000111	6.98e-07	3940	23.7	9080	21.8	1.09
121	35	MA0104.4	MYCN	MA0104.4	VVCCACGTGGBB	MYCN	0.000123	7.7e-07	10900	65.8	26500	63.5	1.04
122	11	MA0813.1	TFAP2B	MA0813.1	TGCCCYBRGGGCA	TFAP2B	0.000125	7.73e-07	2560	15.4	5740	13.8	1.12
123	51	MA0767.1	GCM2	MA0767.1	BATGCGGGTR	GCM2	0.000175	1.07e-06	3630	21.8	8330	20	1.09
124	35	MA1464.1	ARNT2	MA1464.1	GTCACGTGMN	ARNT2	0.000203	1.24e-06	6530	39.3	15500	37.1	1.06
125	52	MA1979.1	ZNF416	MA1979.1	TATCTGGGCAH	ZNF416	0.000223	1.35e-06	8950	53.9	21500	51.6	1.04
126	35	MA0147.3	MYC	MA0147.3	NNCCACGTGCNB	MYC	0.000242	1.45e-06	8490	51.1	20400	48.8	1.05
127	35	MA0697.2	Zic3	MA0697.2	CNCAGCAGGAGNN	Zic3	0.000263	1.56e-06	6140	37	14500	34.8	1.06
128	35	MA1099.2	HES1	MA1099.2	GGCRCGTGBC	HES1	0.000328	1.94e-06	1110	6.69	2340	5.6	1.19
129	50	MA1629.1	Zic2	MA1629.1	NDCACAGCAGGDRG	Zic2	0.000373	2.19e-06	10800	64.9	26200	62.7	1.03
130	51	MA0646.1	GCM1	MA0646.1	BATGCGGGTAC	GCM1	0.000406	2.36e-06	5950	35.8	14100	33.7	1.06
131	35	MA0649.1	HEY2	MA0649.1	GRCACGTGYC	HEY2	0.000978	5.64e-06	4350	26.2	10100	24.3	1.08
132	35	MA0616.2	HES2	MA0616.2	GGCACGTGYC	HES2	0.00107	6.12e-06	5770	34.8	13700	32.7	1.06
133	53	MA1971.1	ZBED2	MA1971.1	NNMMCGAAACCNNV	ZBED2	0.00115	6.52e-06	7600	45.8	18200	43.6	1.05
134	54	MA1555.1	RXRB	MA1555.1	RRGGTCATGACCYY	RXRB	0.00134	7.55e-06	4650	28	10900	26.1	1.07
135	55	MA1474.1	CREB3L4	MA1474.1	YGCCACGTCAYC	CREB3L4	0.00305	1.71e-05	7440	44.8	17800	42.7	1.05
136	56	MA1557.1	SMAD5	MA1557.1	YGTCTAGACA	SMAD5	0.00326	1.81e-05	4190	25.2	9790	23.5	1.08
10	61	10-AGGATTGCTTG	STREME-10	10-AGGATTGCTTG	10-AGGATTGCTTG	AGGATTGCTTG	0.00337	0.000337	543	3.27	1140	2.72	1.2
137	46	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	0.00353	1.95e-05	1570	9.43	3450	8.27	1.14
138	56	MA0861.1	TP73	MA0861.1	DRCATGTCNNRACAYGYM	TP73	0.0036	1.97e-05	3640	21.9	8450	20.2	1.08
139	46	MA0764.3	ETV4	MA0764.3	ACCGGAAGTR	ETV4	0.00425	2.31e-05	5820	35	13800	33.1	1.06
140	35	MA0603.1	Arntl	MA0603.1	NGTCACGTGH	Arntl	0.00504	2.72e-05	8870	53.4	21500	51.4	1.04
141	35	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	0.00585	3.14e-05	5660	34.1	13400	32.2	1.06
142	46	MA0765.3	ETV5	MA0765.3	ACCGGAAGTR	ETV5	0.00642	3.42e-05	3460	20.9	8040	19.3	1.08
143	57	MA1528.1	NFIX	MA1528.1	STTGGCRNNGTGCCARB	NFIX	0.00654	3.45e-05	3670	22.1	8550	20.5	1.08
144	57	MA0671.1	NFIX	MA0671.1	NNTGCCAAN	NFIX	0.00838	4.4e-05	16300	98.1	40700	97.5	1.01
145	35	MA1652.1	ZKSCAN5	MA1652.1	NNRGGARGTGAGRR	ZKSCAN5	0.00999	5.2e-05	8250	49.7	19900	47.8	1.04
146	58	MA1730.1	ZNF708	MA1730.1	NNRGCTGTRCCTCCY	ZNF708	0.0117	6.03e-05	7550	45.5	18200	43.6	1.04
147	35	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	0.0129	6.61e-05	5540	33.4	13200	31.6	1.06
148	35	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	0.0132	6.74e-05	5130	30.9	12200	29.1	1.06
149	35	MA0103.3	ZEB1	MA0103.3	SNCACCTGSVN	ZEB1	0.0162	8.21e-05	14100	84.8	34800	83.4	1.02
150	59	MA1715.1	ZNF707	MA1715.1	CCCCACTCCTGGTAC	ZNF707	0.0195	9.83e-05	3310	19.9	7700	18.4	1.08
151	60	GCCTGTAATCCCAGC	MEME-1	GCCTGTAATCCCAGC	GCCTGTAATCCCAGC	GCCTGTAATCCCAGC	0.021	0.000105	280	1.69	518	1.24	1.36
152	35	MA0822.1	HES7	MA0822.1	YGGCACGTGCCR	HES7	0.0212	0.000105	750	4.52	1580	3.78	1.2
153	60	MA0712.2 (OTX2)	STREME-7	7-CCTGTAATCCCAGC	CCTGTAATCCCAGC	OTX2	0.0394	0.000195	290	1.75	546	1.31	1.34
11	62	MA1616.1 (Prdm15)	STREME-9	9-GAACTCCTGGRCT	GAACTCCTGGRCT	Prdm15	0.246	0.0224	40	0.24	64	0.15	1.59
12	63	MA1125.1 (ZNF384)	MEME-2	HWAAAAAAAAAAAAA	HWAAAAAAAAAAAAA	ZNF384	0.636	0.0516	452	2.72	1030	2.47	1.1
13	64	11-AGGTTGCAGTGA	STREME-11	11-AGGTTGCAGTGA	11-AGGTTGCAGTGA	AGGTTGCAGTGA	0.67	0.0516	34	0.2	58	0.14	1.49
14	65	MA0478.1 (FOSL2)	MEME-3	TGASTCAT	TGASTCAT	FOSL2	4.32	0.309	35	0.21	78	0.19	1.15

ER_rat <- 1.25

DOX_24_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DOX_24_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

DOX_24_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*2), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./2,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DOX_24_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

EPI 3 hour

EPI_3_DAR_DEG_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_3_DEG_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
EPI_3_DAR_DEG_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_3_DEG_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
EPI_3_DAR_DEG_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_3_DEG_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
EPI_3_DAR_DEG_sea_all <- rbind(EPI_3_DAR_DEG_sea_disc, EPI_3_DAR_DEG_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

EPI_3_DAR_DEG_combo <- EPI_3_DAR_DEG_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., EPI_3_DAR_DEG_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

EPI_3_DAR_DEG_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in MTX  v VEH") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in MTX v VEH
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA0117.2 (Mafb)	STREME-1	1-MATGTACTGACTDCA	MATGTACTGACTDCA	Mafb	1.45e-08	1.45e-08	11	8.46	49	0.39	23.2
2	2	2-AATACAGTTCSA	STREME-2	2-AATACAGTTCSA	AATACAGTTCSA	AATACAGTTCSA	0.0117	0.00583	9	6.92	283	2.23	3.41
3	3	3-CRGGGTTTKAGW	STREME-3	3-CRGGGTTTKAGW	CRGGGTTTKAGW	CRGGGTTTKAGW	0.0977	0.0326	12	9.23	611	4.82	2.06
4	4	MA1125.1 (ZNF384)	MEME-1	WBTTTTTKTTTKTTT	WBTTTTTKTTTKTTT	ZNF384	0.142	0.0354	3	2.31	68	0.54	5.61

ER_rat <- 1.25

EPI_3_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("EPI_3_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

EPI_3_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*.5), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.5,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("EPI_3_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

EPI 24 hour

EPI_24_DAR_DEG_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_24_DEG_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
EPI_24_DAR_DEG_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_24_DEG_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
EPI_24_DAR_DEG_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_24_DEG_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
EPI_24_DAR_DEG_sea_all <- rbind(EPI_24_DAR_DEG_sea_disc, EPI_24_DAR_DEG_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

EPI_24_DAR_DEG_combo <- EPI_24_DAR_DEG_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., EPI_24_DAR_DEG_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

EPI_24_DAR_DEG_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in MTX  v VEH") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in MTX v VEH
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA1596.1 (ZNF460)	STREME-3	3-CGCCTCCC	CGCCTCCC	ZNF460	6.47e-22	4.98e-22	2400	15.2	5310	12	1.27
2	2	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	6.19e-20	2.38e-20	3170	20.2	7360	16.7	1.21
3	2	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	1.3e-19	3.34e-20	2010	12.8	4410	9.99	1.28
4	2	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	4.4e-18	8.46e-19	3530	22.5	8380	19	1.18
5	3	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	1.06e-17	1.45e-18	2020	12.9	4480	10.2	1.27
6	20	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	1.13e-17	1.45e-18	1870	11.9	4100	9.29	1.28
7	4	5-BCSSGV	STREME-5	5-BCSSGV	BCSSGV	BCSSGV	4.6e-17	5.05e-18	2190	13.9	4930	11.2	1.25
8	5	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	5.48e-17	5.27e-18	2130	13.6	4780	10.8	1.25
9	6	1-CCCGGCG	STREME-1	1-CCCGGCG	CCCGGCG	CCCGGCG	1.61e-16	1.37e-17	2280	14.6	5190	11.8	1.24
10	7	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	3.11e-16	2.39e-17	2430	15.5	5580	12.6	1.23
11	8	2-CGCGCG	STREME-2	2-CGCGCG	CGCGCG	CGCGCG	5.66e-16	3.95e-17	3200	20.4	7590	17.2	1.19
12	2	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	8.45e-16	5.41e-17	2880	18.4	6770	15.3	1.2
13	9	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	9.26e-16	5.48e-17	4720	30	11600	26.4	1.14
14	10	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	2.91e-15	1.6e-16	2810	17.9	6600	14.9	1.2
15	2	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	8.51e-15	4.36e-16	6730	42.9	17200	39	1.1
16	11	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	1.53e-14	7.35e-16	2430	15.5	5640	12.8	1.21
17	2	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	6.3e-14	2.85e-15	2990	19	7120	16.1	1.18
18	2	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	8.44e-14	3.6e-15	2250	14.3	5200	11.8	1.22
19	12	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	3e-13	1.22e-14	4360	27.8	10800	24.5	1.13
20	2	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	7.85e-13	3.02e-14	3410	21.7	8280	18.8	1.16
21	2	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	1.46e-12	5.27e-14	2400	15.3	5640	12.8	1.2
22	2	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	1.51e-12	5.27e-14	3300	21	8000	18.1	1.16
23	13	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	1.58e-12	5.28e-14	3540	22.5	8630	19.5	1.15
24	14	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	1.69e-12	5.43e-14	2740	17.4	6520	14.8	1.18
25	15	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	2.14e-12	6.59e-14	2890	18.4	6930	15.7	1.17
26	2	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	2.32e-12	6.87e-14	2160	13.8	5020	11.4	1.21
27	13	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	2.79e-12	7.95e-14	4280	27.2	10600	24.1	1.13
28	16	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	4.86e-12	1.33e-13	5790	36.9	14800	33.5	1.1
29	17	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	6.4e-12	1.7e-13	5380	34.2	13600	30.9	1.11
30	13	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	1.29e-11	3.31e-13	1480	9.41	3300	7.47	1.26
31	2	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	3.59e-11	8.73e-13	3410	21.7	8360	18.9	1.15
32	2	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	3.63e-11	8.73e-13	6670	42.5	17200	39.1	1.09
33	2	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	4.91e-11	1.14e-12	5790	36.9	14800	33.6	1.1
34	2	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	5.03e-11	1.14e-12	5350	34	13600	30.8	1.1
35	20	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	6.56e-11	1.44e-12	2170	13.8	5110	11.6	1.2
36	2	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	7.44e-11	1.59e-12	6970	44.4	18100	41	1.08
37	2	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	8.44e-11	1.73e-12	3110	19.8	7580	17.2	1.15
38	12	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	8.55e-11	1.73e-12	6750	43	17500	39.6	1.08
39	20	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	9.72e-11	1.92e-12	7070	45	18400	41.6	1.08
40	2	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	1.11e-10	2.14e-12	4730	30.1	11900	27.1	1.11
41	18	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	1.75e-10	3.28e-12	2230	14.2	5280	12	1.19
42	15	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	2.82e-10	5.16e-12	6920	44.1	18000	40.8	1.08
43	19	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	3.36e-10	6.01e-12	7760	49.4	20300	46.1	1.07
44	20	MA1653.1 (ZNF148)	STREME-6	6-CCTCCCC	CCTCCCC	ZNF148	5.46e-10	9.5e-12	9600	61.2	25600	57.9	1.06
45	2	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	5.56e-10	9.5e-12	5960	37.9	15400	34.8	1.09
46	21	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	5.82e-10	9.74e-12	3710	23.6	9230	20.9	1.13
47	2	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	7.54e-10	1.23e-11	2860	18.2	6960	15.8	1.16
48	22	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	7.78e-10	1.25e-11	977	6.22	2100	4.75	1.31
49	2	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	1.16e-09	1.82e-11	8880	56.6	23500	53.3	1.06
50	2	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	1.51e-09	2.32e-11	6340	40.4	16400	37.2	1.08
51	15	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	1.84e-09	2.77e-11	7260	46.3	19000	43.1	1.07
52	5	MA1587.1	ZNF135	MA1587.1	CCTCGACCTCCYRR	ZNF135	3.88e-09	5.74e-11	5990	38.1	15500	35.1	1.09
53	15	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	4.44e-09	6.44e-11	6550	41.7	17000	38.6	1.08
54	23	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	9.94e-09	1.42e-10	4500	28.7	11400	25.9	1.11
55	13	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	2.27e-08	3.18e-10	12200	77.5	33100	74.9	1.03
56	2	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	3.41e-08	4.68e-10	1130	7.22	2530	5.74	1.26
57	24	MA0751.1	ZIC4	MA0751.1	GRCCCCCCGCKGYGH	ZIC4	4.38e-08	5.8e-10	1060	6.76	2360	5.34	1.27
58	23	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	4.4e-08	5.8e-10	2720	17.3	6680	15.1	1.15
59	25	MA1542.1	OSR1	MA1542.1	HGCTACYGTD	OSR1	4.45e-08	5.8e-10	10500	66.6	28200	63.8	1.04
60	23	MA0024.3	E2F1	MA0024.3	TTTGGCGCCAAA	E2F1	5.81e-08	7.45e-10	1970	12.6	4710	10.7	1.18
61	26	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	6.15e-08	7.75e-10	7640	48.6	20200	45.7	1.07
62	27	MA0694.1	ZBTB7B	MA0694.1	RCGACCACCGAA	ZBTB7B	7.21e-08	8.95e-10	6660	42.4	17400	39.5	1.07
63	23	MA0470.2	E2F4	MA0470.2	TTTTGGCGCCAWWW	E2F4	7.34e-08	8.97e-10	1770	11.3	4180	9.47	1.19
64	28	MA1985.1	ZNF669	MA1985.1	GGGGYGAYGACCRCT	ZNF669	1.91e-07	2.3e-09	5500	35	14200	32.3	1.08
65	23	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	2.75e-07	3.26e-09	4840	30.8	12500	28.2	1.09
66	29	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	5.47e-07	6.37e-09	2870	18.3	7130	16.2	1.13
67	2	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	5.61e-07	6.44e-09	7610	48.5	20200	45.6	1.06
68	16	MA0616.2	HES2	MA0616.2	GGCACGTGYC	HES2	7.01e-07	7.92e-09	3070	19.6	7680	17.4	1.12
69	2	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	8.19e-07	9.13e-09	6070	38.6	15900	36	1.08
70	16	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	8.75e-07	9.61e-09	3750	23.9	9520	21.6	1.11
71	29	MA0750.2	ZBTB7A	MA0750.2	NVCCGGAAGTGSV	ZBTB7A	1.11e-06	1.21e-08	5900	37.6	15400	34.9	1.08
72	2	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	1.21e-06	1.29e-08	4050	25.8	10400	23.4	1.1
73	30	MA0597.2	THAP1	MA0597.2	VSGCAGGGCASV	THAP1	1.44e-06	1.52e-08	5760	36.7	15000	34	1.08
74	31	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	1.79e-06	1.86e-08	2150	13.7	5240	11.9	1.15
75	32	MA1727.1	ZNF417	MA1727.1	VRBVNTGGGCGCCAM	ZNF417	2.28e-06	2.34e-08	3030	19.3	7590	17.2	1.12
76	33	MA1715.1	ZNF707	MA1715.1	CCCCACTCCTGGTAC	ZNF707	2.77e-06	2.81e-08	6070	38.6	15900	36	1.07
77	34	MA1941.1	ETV2::FIGLA	MA1941.1	RSCGGAARCAGSTGBN	ETV2::FIGLA	3.58e-06	3.58e-08	5220	33.3	13600	30.8	1.08
78	27	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	4.58e-06	4.52e-08	7840	49.9	20900	47.3	1.06
79	16	MA1099.2	HES1	MA1099.2	GGCRCGTGBC	HES1	5.04e-06	4.91e-08	2410	15.4	5960	13.5	1.14
80	24	MA1584.1	ZIC5	MA1584.1	VGACCCCCCGCTGHGM	ZIC5	5.79e-06	5.56e-08	1320	8.39	3090	6.99	1.2
81	2	MA1578.1	VEZF1	MA1578.1	CCCCCCMYDH	VEZF1	7.7e-06	7.31e-08	4690	29.8	12100	27.5	1.09
82	35	MA0067.2	PAX2	MA0067.2	BCAVTSRAGCGTGACGR	PAX2	7.83e-06	7.34e-08	4530	28.8	11700	26.5	1.09
83	16	MA1464.1	ARNT2	MA1464.1	GTCACGTGMN	ARNT2	1.2e-05	1.11e-07	3750	23.9	9590	21.7	1.1
84	2	MA0732.1	EGR3	MA0732.1	HHMCGCCCACGCAHH	EGR3	1.57e-05	1.44e-07	1400	8.93	3320	7.53	1.19
85	20	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	1.62e-05	1.46e-07	1740	11.1	4210	9.54	1.16
86	35	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	2.3e-05	2.06e-07	3270	20.8	8300	18.8	1.11
87	16	MA0522.3	TCF3	MA0522.3	NVCACCTGCNN	TCF3	2.65e-05	2.34e-07	12000	76.7	32900	74.5	1.03
88	36	MA1719.1	ZNF816	MA1719.1	DRRKGGGGACATGCHGGG	ZNF816	2.73e-05	2.39e-07	2550	16.3	6380	14.5	1.13
89	27	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	2.84e-05	2.45e-07	6540	41.6	17300	39.2	1.06
90	37	MA1982.1	ZNF574	MA1982.1	VGSCTAGAGMGGCCS	ZNF574	4.64e-05	3.97e-07	5320	33.9	13900	31.6	1.07
91	11	MA0155.1	INSM1	MA0155.1	TGYCWGGGGGCR	INSM1	5.27e-05	4.45e-07	3900	24.8	10000	22.7	1.09
92	24	MA0696.1	ZIC1	MA0696.1	GACCCCCYGCTGTG	ZIC1	7.19e-05	6.01e-07	2190	13.9	5420	12.3	1.13
93	34	MA1966.1	TFAP4::ETV1	MA1966.1	RSCGGAAGCAGSTGKN	TFAP4::ETV1	7.5e-05	6.2e-07	2360	15	5890	13.3	1.13
94	20	MA0528.2	ZNF263	MA0528.2	VNGGGGAGGASG	ZNF263	8.3e-05	6.79e-07	2400	15.3	6000	13.6	1.13
95	19	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	8.4e-05	6.8e-07	9460	60.2	25600	57.9	1.04
96	34	MA1945.1	ETV5::FIGLA	MA1945.1	RGCGGAARCAGGTGG	ETV5::FIGLA	8.77e-05	7.02e-07	6470	41.2	17100	38.8	1.06
97	15	MA0813.1	TFAP2B	MA0813.1	TGCCCYBRGGGCA	TFAP2B	9.11e-05	7.22e-07	2910	18.5	7370	16.7	1.11
98	16	MA1106.1	HIF1A	MA1106.1	SBACGTGCNN	HIF1A	9.59e-05	7.52e-07	7530	48	20100	45.6	1.05
99	16	MA0464.2	BHLHE40	MA0464.2	VKCACGTGMC	BHLHE40	0.000107	8.31e-07	6800	43.3	18100	40.9	1.06
100	15	MA0872.1	TFAP2A	MA0872.1	TGCCCYSRGGGCA	TFAP2A	0.000123	9.48e-07	2250	14.3	5600	12.7	1.13
101	27	MA0695.1	ZBTB7C	MA0695.1	RCGACCACCGAN	ZBTB7C	0.000132	1e-06	5280	33.6	13900	31.4	1.07
102	38	MA1656.1	ZNF449	MA1656.1	NNAAGCCCAACCNN	ZNF449	0.000149	1.12e-06	12400	79.1	34100	77.2	1.03
103	39	MA0052.4 (MEF2A)	STREME-7	7-TACTAAAAATACA	TACTAAAAATACA	MEF2A	0.000218	1.63e-06	130	0.83	204	0.46	1.8
104	16	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	0.000268	1.98e-06	7020	44.7	18700	42.4	1.05
105	15	MA0815.1	TFAP2C	MA0815.1	TGCCCYSRGGGCA	TFAP2C	0.000284	2.08e-06	2650	16.9	6700	15.2	1.11
106	19	MA1581.1	ZBTB6	MA1581.1	DNSCTTGAGCCNV	ZBTB6	0.000444	3.22e-06	10900	69.3	29700	67.2	1.03
107	16	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	0.000519	3.73e-06	4160	26.5	10800	24.5	1.08
108	11	MA1930.1	CTCF	MA1930.1	CTGCAGTKCCNVCHNNYRGCCASYAGRKGGCRAKC	CTCF	0.00055	3.92e-06	3960	25.2	10300	23.3	1.08
109	16	MA1648.1	TCF12	MA1648.1	NNCACCTGCNN	TCF12	0.000573	4.04e-06	5300	33.8	14000	31.7	1.07
110	16	MA0649.1	HEY2	MA0649.1	GRCACGTGYC	HEY2	0.000632	4.42e-06	5100	32.5	13400	30.4	1.07
111	16	MA0259.1	ARNT::HIF1A	MA0259.1	VBACGTGC	ARNT::HIF1A	0.000669	4.64e-06	4060	25.9	10600	24	1.08
112	29	MA0765.3	ETV5	MA0765.3	ACCGGAAGTR	ETV5	0.000937	6.43e-06	3500	22.3	9060	20.5	1.09
113	20	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	0.00122	8.31e-06	1170	7.48	2820	6.38	1.17
114	40	MA1979.1	ZNF416	MA1979.1	TATCTGGGCAH	ZNF416	0.00151	1.02e-05	10700	68.1	29200	66	1.03
115	41	MA1149.1	RARA::RXRG	MA1149.1	RRGGTCAHNNNRRGGTCA	RARA::RXRG	0.00175	1.17e-05	8400	53.5	22700	51.3	1.04
116	16	MA1631.1	ASCL1	MA1631.1	NNGCACCTGCYNB	ASCL1	0.00204	1.35e-05	7620	48.6	20500	46.4	1.05
117	29	MA0764.3	ETV4	MA0764.3	ACCGGAAGTR	ETV4	0.00222	1.46e-05	5820	37.1	15500	35.1	1.06
118	12	MA0163.1	PLAG1	MA0163.1	GGGGCCCWAGGGGG	PLAG1	0.00228	1.49e-05	1220	7.78	2950	6.68	1.16
119	42	MA1684.1	Foxn1	MA1684.1	RGAMGC	Foxn1	0.00287	1.86e-05	1330	8.5	3250	7.37	1.15
120	43	MA2002.1	Zfp335	MA2002.1	VNTCAGGCANH	Zfp335	0.00296	1.89e-05	6670	42.5	17800	40.4	1.05
121	44	MA0511.2	RUNX2	MA0511.2	WAACCGCAA	RUNX2	0.00299	1.9e-05	10300	65.9	28200	63.9	1.03
122	11	MA1929.1	CTCF	MA1929.1	CTGCAGTKCCNNNNNYNRCCASYAGRKGGCRSWG	CTCF	0.0038	2.4e-05	1450	9.25	3570	8.09	1.14
123	34	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	0.0045	2.81e-05	4470	28.5	11800	26.7	1.07
124	34	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	0.00502	3.11e-05	4750	30.2	12500	28.4	1.07
125	45	MA0145.2	Tfcp2l1	MA0145.2	CCAGYYYVADCCRG	Tfcp2l1	0.00687	4.22e-05	14000	89.4	38900	88.2	1.01
126	46	MA0767.1	GCM2	MA0767.1	BATGCGGGTR	GCM2	0.00736	4.49e-05	4720	30.1	12500	28.3	1.06
127	47	MA1972.1	ZFP14	MA1972.1	GGAGGCHCHGGARBG	ZFP14	0.00763	4.62e-05	10300	65.5	28100	63.6	1.03
128	34	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	0.00793	4.76e-05	4960	31.6	13100	29.7	1.06
129	48	MA1475.1	CREB3L4	MA1475.1	GRTGACGTCAYC	CREB3L4	0.0124	7.39e-05	3470	22.1	9050	20.5	1.08
7	52	MA0509.3 (RFX1)	STREME-4	4-MTGTTGCCCAGGC	MTGTTGCCCAGGC	RFX1	0.0152	0.00217	7420	47.3	20300	45.9	1.03
130	41	MA0159.1	RARA::RXRA	MA0159.1	RGKTCANVGRSAGGTCA	RARA::RXRA	0.0159	9.39e-05	5390	34.3	14400	32.5	1.06
131	49	MA1555.1	RXRB	MA1555.1	RRGGTCATGACCYY	RXRB	0.0172	0.000101	4600	29.3	12200	27.6	1.06
132	50	MA1710.1	ZNF257	MA1710.1	VDGAGGCRAGRG	ZNF257	0.0245	0.000143	3290	20.9	8580	19.4	1.08
133	29	MA0028.2	ELK1	MA0028.2	ACCGGAAGTR	ELK1	0.0255	0.000148	3380	21.5	8820	20	1.08
134	16	MA1560.1	SOHLH2	MA1560.1	YGCACGTGCN	SOHLH2	0.0259	0.000149	11000	70	30200	68.3	1.03
135	51	MA1964.1	SMAD2	MA1964.1	NBCCAGACDN	SMAD2	0.0328	0.000187	4030	25.7	10600	24.1	1.07
136	16	MA1934.1	ERF::FIGLA	MA1934.1	RCCGGAARCASCTGBN	ERF::FIGLA	0.0334	0.000189	2880	18.3	7470	16.9	1.08
137	48	MA0615.1	Gmeb1	MA0615.1	BHBBKKACGTMMNWNNN	Gmeb1	0.0371	0.000208	6950	44.3	18700	42.5	1.04
8	53	8-CAGTGAGCTGWG	STREME-8	8-CAGTGAGCTGWG	CAGTGAGCTGWG	CAGTGAGCTGWG	1.58	0.197	2060	13.1	5660	12.8	1.03
9	54	MA0476.1 (FOS)	MEME-2	TGASTCAT	TGASTCAT	FOS	7.26	0.806	154	0.98	456	1.03	0.954
10	39	MA1125.1 (ZNF384)	MEME-1	AAAAAAAAAAAAAAA	AAAAAAAAAAAAAAA	ZNF384	8.44	0.844	1850	11.8	5330	12.1	0.975

ER_rat <- 1.25

EPI_24_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("EPI_24_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

EPI_24_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("EPI_24_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

DNR 3 hour

DNR_3_DAR_DEG_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_3_DEG_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DNR_3_DAR_DEG_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_3_DEG_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DNR_3_DAR_DEG_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_3_DEG_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DNR_3_DAR_DEG_sea_all <- rbind(DNR_3_DAR_DEG_sea_disc, DNR_3_DAR_DEG_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DNR_3_DAR_DEG_combo <- DNR_3_DAR_DEG_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DNR_3_DAR_DEG_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

DNR_3_DAR_DEG_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in MTX  v VEH") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in MTX v VEH
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA1721.1 (ZNF93)	STREME-4	4-GCCGGGGCCGC	GCCGGGGCCGC	ZNF93	3.14e-12	2.85e-12	113	19.8	1770	8.92	2.23
2	2	6-CCGRAGC	STREME-6	6-CCGRAGC	CCGRAGC	CCGRAGC	9.07e-09	4.12e-09	308	53.8	7890	39.7	1.36
3	3	MA1653.1 (ZNF148)	STREME-7	7-GCCCCCTCC	GCCCCCTCC	ZNF148	2.73e-08	8.26e-09	266	46.5	6570	33	1.41
4	4	5-CGDGACGHGV	STREME-5	5-CGDGACGHGV	CGDGACGHGV	CGDGACGHGV	2.52e-06	5.72e-07	259	45.3	6620	33.3	1.36
5	5	MA1721.1 (ZNF93)	MEME-2	SSCGCCGCCGCCGCC	SSCGCCGCCGCCGCC	ZNF93	6.23e-06	1.13e-06	297	51.9	7940	39.9	1.3
6	6	MA0742.2 (KLF12)	STREME-2	2-CCGCCC	CCGCCC	KLF12	8.52e-06	1.29e-06	223	39	5540	27.9	1.4
7	20	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	3.18e-05	4.13e-06	394	68.9	11500	57.7	1.19
8	7	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	0.000297	3.37e-05	400	69.9	11900	59.7	1.17
9	8	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	0.000413	4.17e-05	393	68.7	11600	58.5	1.17
10	7	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	0.000692	6.29e-05	389	68	11500	58	1.17
11	9	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	0.000948	7.83e-05	213	37.2	5550	27.9	1.34
7	16	1-CCATCCCG	STREME-1	1-CCATCCCG	CCATCCCG	CCATCCCG	0.00111	0.000159	178	31.1	4790	24.1	1.3
12	6	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	0.00132	9.97e-05	241	42.1	6480	32.6	1.3
13	7	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	0.00158	0.000111	328	57.3	9440	47.4	1.21
8	17	MA1125.1 (ZNF384)	MEME-1	TTTTTTTTTTTTTWT	TTTTTTTTTTTTTWT	ZNF384	0.00232	0.000289	23	4.02	336	1.69	2.47
14	7	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	0.00248	0.000161	340	59.4	9900	49.8	1.2
15	10	MA0024.3	E2F1	MA0024.3	TTTGGCGCCAAA	E2F1	0.00794	0.000481	223	39	6040	30.4	1.29
16	6	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	0.00986	0.00056	315	55.1	9150	46	1.2
17	11	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	0.0115	0.000613	269	47	7600	38.2	1.23
18	9	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	0.0128	0.000614	267	46.7	7540	37.9	1.23
19	12	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	0.0129	0.000614	351	61.4	10400	52.5	1.17
20	7	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	0.0231	0.001	361	63.1	10900	54.6	1.16
21	3	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	0.0231	0.001	352	61.5	10500	53	1.16
22	13	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	0.0258	0.00107	121	21.2	2930	14.7	1.45
23	14	MA0116.1	Znf423	MA0116.1	GSMMCCYARGGKKBM	Znf423	0.0294	0.00114	18	3.15	196	0.99	3.35
24	15	MA1656.1	ZNF449	MA1656.1	NNAAGCCCAACCNN	ZNF449	0.0301	0.00114	521	91.1	17000	85.4	1.07
9	18	3-AGAAGGCG	STREME-3	3-AGAAGGCG	AGAAGGCG	AGAAGGCG	0.0399	0.00444	449	78.5	14600	73.5	1.07
25	3	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	0.0427	0.00155	281	49.1	8130	40.9	1.2
10	19	MA0814.2 (TFAP2C)	STREME-8	8-ACCTGAGCCGGGC	ACCTGAGCCGGGC	TFAP2C	0.108	0.0108	136	23.8	3910	19.7	1.22
11	20	MA1107.2 (KLF9)	MEME-3	ACACACACRCACACA	ACACACACRCACACA	KLF9	11	1	0	0	0	0	34.7

ER_rat <- 1.25

DNR_3_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DNR_3_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

DNR_3_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DNR_3_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

DNR 24 hour

DNR_24_DAR_DEG_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_24_DEG_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DNR_24_DAR_DEG_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_24_DEG_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DNR_24_DAR_DEG_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_24_DEG_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DNR_24_DAR_DEG_sea_all <- rbind(DNR_24_DAR_DEG_sea_disc, DNR_24_DAR_DEG_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DNR_24_DAR_DEG_combo <- DNR_24_DAR_DEG_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DNR_24_DAR_DEG_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

DNR_24_DAR_DEG_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in MTX  v VEH") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in MTX v VEH
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	2-SGCSNSGCS	STREME-2	2-SGCSNSGCS	SGCSNSGCS	SGCSNSGCS	2.46e-45	1.79e-45	6880	31.9	13400	26.6	1.2
2	2	7-CCGGCC	STREME-7	7-CCGGCC	CCGGCC	CCGGCC	1.43e-42	5.2e-43	4730	22	8800	17.4	1.26
3	3	MA1529.1 (NHLH2)	STREME-9	9-CGCCCC	CGCCCC	NHLH2	1.65e-37	4e-38	7510	34.9	15100	29.8	1.17
4	3	MA0742.2 (KLF12)	STREME-3	3-CCCGCCCCCA	CCCGCCCCCA	KLF12	4.26e-37	7.75e-38	3430	16	6180	12.2	1.3
5	4	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	6.03e-35	8.77e-36	3380	15.7	6120	12.1	1.3
6	30	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	1.3e-34	1.58e-35	7740	35.9	15700	31	1.16
7	4	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	4.91e-32	5.1e-33	3910	18.2	7320	14.5	1.25
8	4	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	9.28e-31	8.44e-32	5490	25.5	10800	21.4	1.19
9	4	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	9.5e-30	7.67e-31	4750	22.1	9190	18.2	1.21
10	5	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	1.67e-29	1.21e-30	4140	19.2	7880	15.6	1.23
11	6	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	2.91e-28	1.92e-29	7970	37	16400	32.6	1.14
12	7	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	2.34e-26	1.42e-27	5090	23.6	10000	19.9	1.19
13	4	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	2.82e-26	1.58e-27	9240	42.9	19400	38.5	1.12
14	4	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	3.93e-26	2.04e-27	4600	21.4	8980	17.8	1.2
15	8	1-MCGSASS	STREME-1	1-MCGSASS	MCGSASS	MCGSASS	1.09e-25	5.31e-27	5260	24.4	10400	20.7	1.18
16	9	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	3.22e-25	1.46e-26	4410	20.5	8580	17	1.2
17	4	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	4.54e-25	1.94e-26	6350	29.5	12900	25.6	1.15
18	4	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	6.07e-25	2.45e-26	9790	45.5	20700	41.1	1.11
19	4	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	1.19e-24	4.54e-26	10300	48	22000	43.6	1.1
20	10	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	1.9e-24	6.89e-26	8270	38.4	17300	34.2	1.12
21	11	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	2.14e-24	7.41e-26	4390	20.4	8570	17	1.2
22	12	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	6.1e-24	2.02e-25	8440	39.2	17700	35	1.12
23	10	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	8.82e-24	2.79e-25	8890	41.3	18700	37.1	1.11
24	10	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	1.1e-23	3.33e-25	7950	36.9	16600	32.8	1.13
25	4	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	1.41e-23	4.1e-25	4420	20.5	8660	17.2	1.2
26	13	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	2.39e-23	6.68e-25	6680	31	13700	27.1	1.14
27	4	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	7.79e-23	2.1e-24	6730	31.2	13800	27.4	1.14
28	4	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	4.25e-22	1.1e-23	2190	10.2	3930	7.79	1.3
29	4	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	1.5e-21	3.77e-23	7310	34	15200	30.1	1.13
30	14	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	4.87e-21	1.18e-22	3520	16.3	6780	13.4	1.22
31	15	MA0024.3	E2F1	MA0024.3	TTTGGCGCCAAA	E2F1	6.38e-21	1.5e-22	5160	24	10400	20.6	1.16
32	15	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	2.3e-20	5.22e-22	7270	33.8	15100	30	1.12
33	4	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	2.81e-20	6.19e-22	5690	26.4	11600	23	1.15
34	4	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	5.09e-20	1.09e-21	5510	25.6	11200	22.2	1.15
35	16	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	1.27e-19	2.64e-21	8590	39.9	18200	36.1	1.11
36	16	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	2.78e-19	5.62e-21	6570	30.5	13600	27	1.13
37	4	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	3.68e-19	7.24e-21	6830	31.7	14200	28.2	1.13
38	17	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	4.89e-19	9.35e-21	6860	31.8	14300	28.3	1.13
39	4	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	9.53e-19	1.78e-20	4580	21.2	9180	18.2	1.17
40	4	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	1.91e-18	3.47e-20	2240	10.4	4140	8.2	1.27
41	18	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	2.68e-18	4.75e-20	4610	21.4	9270	18.4	1.17
42	7	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	3.41e-18	5.91e-20	4730	22	9550	18.9	1.16
43	19	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	4.96e-18	8.39e-20	3710	17.2	7310	14.5	1.19
44	20	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	2.14e-17	3.54e-19	9140	42.4	19600	38.8	1.09
45	4	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	2.42e-17	3.91e-19	11600	53.9	25300	50.2	1.07
46	11	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	2.57e-17	4.06e-19	9150	42.5	19600	38.8	1.09
47	4	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	3.22e-17	4.98e-19	3550	16.5	6980	13.8	1.19
48	21	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	4.17e-17	6.31e-19	5000	23.2	10200	20.2	1.15
49	22	MA0751.1	ZIC4	MA0751.1	GRCCCCCCGCKGYGH	ZIC4	6.92e-17	1.02e-18	7670	35.6	16200	32.2	1.11
50	7	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	7.03e-17	1.02e-18	3930	18.2	7820	15.5	1.18
51	11	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	8.02e-17	1.14e-18	4140	19.2	8300	16.4	1.17
52	13	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	1.07e-16	1.5e-18	6920	32.1	14500	28.8	1.12
53	11	MA0732.1	EGR3	MA0732.1	HHMCGCCCACGCAHH	EGR3	4.59e-16	6.29e-18	3570	16.6	7070	14	1.18
54	23	MA0067.2	PAX2	MA0067.2	BCAVTSRAGCGTGACGR	PAX2	4.9e-16	6.59e-18	5520	25.6	11400	22.6	1.14
55	24	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	5.28e-16	6.98e-18	5390	25	11100	22	1.14
56	25	MA1973.1	ZKSCAN3	MA1973.1	KDKCCCAGGCTAGCCCABNN	ZKSCAN3	6.11e-16	7.94e-18	7770	36.1	16500	32.7	1.1
57	15	MA0864.2	E2F2	MA0864.2	RWTTTGGCGCCAWWWY	E2F2	7.08e-16	9.03e-18	4150	19.3	8350	16.6	1.17
58	23	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	1.1e-15	1.38e-17	6930	32.2	14600	28.9	1.11
59	4	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	1.5e-15	1.85e-17	5600	26	11600	23	1.13
60	22	MA1578.1	VEZF1	MA1578.1	CCCCCCMYDH	VEZF1	2.25e-15	2.72e-17	9400	43.6	20300	40.2	1.09
61	4	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	2.55e-15	3.04e-17	2640	12.2	5070	10	1.22
62	26	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	4.15e-15	4.86e-17	4330	20.1	8770	17.4	1.16
63	16	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	7.01e-15	8.09e-17	3000	13.9	5860	11.6	1.2
64	27	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	8.56e-15	9.72e-17	10700	49.7	23300	46.2	1.07
65	4	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	9.06e-15	1.01e-16	3150	14.6	6210	12.3	1.19
66	4	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	3.2e-14	3.53e-16	851	3.95	1390	2.75	1.44
67	28	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	5.68e-14	6.16e-16	7330	34	15600	30.9	1.1
68	15	MA0470.2	E2F4	MA0470.2	TTTTGGCGCCAWWW	E2F4	6.05e-14	6.47e-16	2320	10.8	4440	8.81	1.23
69	29	MA1985.1	ZNF669	MA1985.1	GGGGYGAYGACCRCT	ZNF669	6.68e-14	7.03e-16	4960	23.1	10200	20.3	1.14
70	30	MA1596.1 (ZNF460)	STREME-5	5-CCGCCTCC	CCGCCTCC	ZNF460	1.76e-13	1.83e-15	16900	78.5	38200	75.7	1.04
71	17	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	4.43e-13	4.54e-15	4520	21	9290	18.4	1.14
72	4	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	1.61e-12	1.63e-14	1190	5.54	2110	4.17	1.33
73	31	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	2.15e-12	2.14e-14	2270	10.5	4370	8.66	1.22
74	13	MA0163.1	PLAG1	MA0163.1	GGGGCCCWAGGGGG	PLAG1	2.26e-12	2.22e-14	2620	12.2	5130	10.2	1.2
75	32	MA1728.1	ZNF549	MA1728.1	NNTGCTGCCCWR	ZNF549	3.31e-12	3.21e-14	8280	38.5	17900	35.4	1.09
76	13	MA1930.1	CTCF	MA1930.1	CTGCAGTKCCNVCHNNYRGCCASYAGRKGGCRAKC	CTCF	4.3e-12	4.11e-14	5350	24.9	11200	22.2	1.12
77	11	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	4.81e-12	4.54e-14	8680	40.3	18800	37.3	1.08
78	17	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	6.91e-12	6.44e-14	12100	56.1	26700	53	1.06
79	17	MA1648.1	TCF12	MA1648.1	NNCACCTGCNN	TCF12	8.92e-12	8.21e-14	4430	20.6	9140	18.1	1.14
80	33	MA0695.1	ZBTB7C	MA0695.1	RCGACCACCGAN	ZBTB7C	1.44e-11	1.31e-13	13400	62.2	29900	59.2	1.05
81	34	MA0145.2	Tfcp2l1	MA0145.2	CCAGYYYVADCCRG	Tfcp2l1	2.86e-11	2.57e-13	15000	69.5	33700	66.7	1.04
82	33	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	4.45e-11	3.94e-13	10500	48.8	23100	45.8	1.07
83	17	MA1106.1	HIF1A	MA1106.1	SBACGTGCNN	HIF1A	5.36e-11	4.7e-13	11300	52.5	25000	49.5	1.06
84	17	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	1.5e-10	1.3e-12	3740	17.4	7670	15.2	1.14
85	11	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	2.31e-10	1.98e-12	14600	67.8	32800	65	1.04
86	26	MA0750.2	ZBTB7A	MA0750.2	NVCCGGAAGTGSV	ZBTB7A	2.54e-10	2.15e-12	16100	74.6	36300	72	1.04
87	4	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	3.94e-10	3.29e-12	1580	7.32	2970	5.89	1.24
88	4	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	4.73e-10	3.91e-12	2380	11.1	4700	9.32	1.19
89	35	MA1581.1	ZBTB6	MA1581.1	DNSCTTGAGCCNV	ZBTB6	8.73e-10	7.13e-12	14000	65.1	31500	62.4	1.04
90	36	6-CCGAGA	STREME-6	6-CCGAGA	CCGAGA	CCGAGA	1.66e-09	1.34e-11	10500	49	23300	46.1	1.06
91	26	MA0764.3	ETV4	MA0764.3	ACCGGAAGTR	ETV4	1.86e-09	1.49e-11	15300	71.2	34600	68.6	1.04
92	10	MA1569.1	TFAP2E	MA1569.1	YGCCYSRGGCD	TFAP2E	3.26e-09	2.58e-11	1180	5.48	2160	4.29	1.28
93	26	MA0765.3	ETV5	MA0765.3	ACCGGAAGTR	ETV5	5.98e-09	4.68e-11	6100	28.3	13100	25.9	1.09
94	17	MA1099.2	HES1	MA1099.2	GGCRCGTGBC	HES1	6.68e-09	5.16e-11	472	2.19	740	1.47	1.5
95	37	MA1710.1	ZNF257	MA1710.1	VDGAGGCRAGRG	ZNF257	8.39e-09	6.41e-11	10900	50.5	24100	47.8	1.06
96	26	MA0156.3	FEV	MA0156.3	VACCGGAAGTVV	FEV	8.47e-09	6.41e-11	8140	37.8	17800	35.2	1.07
97	17	MA0616.2	HES2	MA0616.2	GGCACGTGYC	HES2	1.38e-08	1.04e-10	7710	35.8	16800	33.2	1.08
98	22	MA0736.1	GLIS2	MA0736.1	GACCCCCCGCRAMG	GLIS2	1.51e-08	1.12e-10	4020	18.7	8400	16.6	1.12
99	17	MA0649.1	HEY2	MA0649.1	GRCACGTGYC	HEY2	3.32e-08	2.44e-10	5500	25.6	11800	23.3	1.1
100	38	MA1972.1	ZFP14	MA1972.1	GGAGGCHCHGGARBG	ZFP14	3.69e-08	2.68e-10	9430	43.8	20800	41.2	1.06
101	39	MA1982.1	ZNF574	MA1982.1	VGSCTAGAGMGGCCS	ZNF574	4.75e-08	3.42e-10	8030	37.3	17500	34.8	1.07
102	11	MA1656.1	ZNF449	MA1656.1	NNAAGCCCAACCNN	ZNF449	7.16e-08	5.1e-10	17300	80.6	39600	78.5	1.03
103	15	MA1727.1	ZNF417	MA1727.1	VRBVNTGGGCGCCAM	ZNF417	1.17e-07	8.23e-10	3300	15.3	6830	13.5	1.13
104	33	MA0694.1	ZBTB7B	MA0694.1	RCGACCACCGAA	ZBTB7B	1.77e-07	1.24e-09	4830	22.4	10300	20.4	1.1
105	17	MA0006.1	Ahr::Arnt	MA0006.1	YGCGTG	Ahr::Arnt	1.98e-07	1.37e-09	5700	26.5	12300	24.3	1.09
106	17	MA1941.1	ETV2::FIGLA	MA1941.1	RSCGGAARCAGSTGBN	ETV2::FIGLA	2.36e-07	1.61e-09	13900	64.6	31400	62.2	1.04
107	14	MA0155.1	INSM1	MA0155.1	TGYCWGGGGGCR	INSM1	2.37e-07	1.61e-09	5870	27.3	12600	25.1	1.09
108	22	MA0696.1	ZIC1	MA0696.1	GACCCCCYGCTGTG	ZIC1	2.63e-07	1.77e-09	4750	22.1	10100	20	1.1
109	17	MA0259.1	ARNT::HIF1A	MA0259.1	VBACGTGC	ARNT::HIF1A	2.65e-07	1.77e-09	3990	18.5	8390	16.6	1.12
110	17	MA0522.3	TCF3	MA0522.3	NVCACCTGCNN	TCF3	5.45e-07	3.6e-09	3760	17.4	7880	15.6	1.12
111	40	MA1587.1	ZNF135	MA1587.1	CCTCGACCTCCYRR	ZNF135	7.18e-07	4.7e-09	5590	26	12000	23.8	1.09
112	22	MA1584.1	ZIC5	MA1584.1	VGACCCCCCGCTGHGM	ZIC5	9.7e-07	6.3e-09	1900	8.8	3770	7.48	1.18
113	41	MA1730.1	ZNF708	MA1730.1	NNRGCTGTRCCTCCY	ZNF708	1.17e-06	7.55e-09	13000	60.2	29200	57.8	1.04
114	42	MA0511.2	RUNX2	MA0511.2	WAACCGCAA	RUNX2	2.66e-06	1.7e-08	14900	69.3	33800	67.1	1.03
115	17	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	3.17e-06	2e-08	9500	44.1	21100	41.8	1.06
116	43	MA1555.1	RXRB	MA1555.1	RRGGTCATGACCYY	RXRB	3.46e-06	2.17e-08	7480	34.8	16400	32.5	1.07
117	17	MA1631.1	ASCL1	MA1631.1	NNGCACCTGCYNB	ASCL1	5.98e-06	3.71e-08	3520	16.3	7400	14.7	1.11
118	44	MA0597.2	THAP1	MA0597.2	VSGCAGGGCASV	THAP1	9.02e-06	5.56e-08	4070	18.9	8650	17.1	1.1
119	17	MA0464.2	BHLHE40	MA0464.2	VKCACGTGMC	BHLHE40	1.03e-05	6.27e-08	9930	46.1	22100	43.9	1.05
120	45	MA0615.1	Gmeb1	MA0615.1	BHBBKKACGTMMNWNNN	Gmeb1	1.18e-05	7.12e-08	13600	63.2	30800	61	1.04
121	43	MA1149.1	RARA::RXRG	MA1149.1	RRGGTCAHNNNRRGGTCA	RARA::RXRG	1.76e-05	1.06e-07	17900	82.9	41000	81.2	1.02
122	46	MA1971.1	ZBED2	MA1971.1	NNMMCGAAACCNNV	ZBED2	1.88e-05	1.12e-07	5290	24.6	11400	22.7	1.08
123	17	MA0147.3	MYC	MA0147.3	NNCCACGTGCNB	MYC	3.55e-05	2.1e-07	7670	35.6	16900	33.6	1.06
124	17	MA1560.1	SOHLH2	MA1560.1	YGCACGTGCN	SOHLH2	3.63e-05	2.13e-07	3090	14.4	6500	12.9	1.12
125	47	MA0682.2 (PITX1)	STREME-4	4-TGGGATTACAGGM	TGGGATTACAGGM	PITX1	4.43e-05	2.58e-07	509	2.36	885	1.75	1.35
126	48	MA1542.1	OSR1	MA1542.1	HGCTACYGTD	OSR1	6.61e-05	3.81e-07	16300	75.6	37200	73.7	1.03
127	17	MA1464.1	ARNT2	MA1464.1	GTCACGTGMN	ARNT2	7.92e-05	4.53e-07	5310	24.7	11500	22.9	1.08
128	14	MA0139.1	CTCF	MA0139.1	YGRCCASYAGRKGGCRSYR	CTCF	0.000135	7.66e-07	5300	24.6	11500	22.8	1.08
129	17	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	0.000178	1e-06	9540	44.3	21300	42.3	1.05
130	49	MA1575.1	THRB	MA1575.1	DTGACCTBRNYVAGGTCAH	THRB	0.000204	1.14e-06	3090	14.3	6520	12.9	1.11
131	17	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	0.000218	1.21e-06	9510	44.2	21300	42.1	1.05
132	17	MA1966.1	TFAP4::ETV1	MA1966.1	RSCGGAAGCAGSTGKN	TFAP4::ETV1	0.000228	1.26e-06	15900	74	36500	72.2	1.03
133	35	MA1649.1	ZBTB12	MA1649.1	NYCTRGAACHN	ZBTB12	0.000253	1.38e-06	16700	77.8	38400	76	1.02
134	33	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	0.000256	1.39e-06	3290	15.3	6990	13.9	1.1
135	50	MA1652.1	ZKSCAN5	MA1652.1	NNRGGARGTGAGRR	ZKSCAN5	3e-04	1.61e-06	16200	75.2	37100	73.5	1.02
136	51	MA1684.1	Foxn1	MA1684.1	RGAMGC	Foxn1	0.00044	2.35e-06	639	2.97	1180	2.33	1.27
137	4	MA0528.2	ZNF263	MA0528.2	VNGGGGAGGASG	ZNF263	0.000537	2.85e-06	18100	84	41600	82.5	1.02
138	17	MA0603.1	Arntl	MA0603.1	NGTCACGTGH	Arntl	0.000551	2.9e-06	6200	28.8	13600	27	1.07
139	17	MA0104.4	MYCN	MA0104.4	VVCCACGTGGBB	MYCN	0.000576	3.01e-06	9260	43	20700	41.1	1.05
140	47	MA0682.2 (PITX1)	MEME-2	WGCTGGGATTACAGG	WGCTGGGATTACAGG	PITX1	0.00112	5.82e-06	862	4	1660	3.29	1.22
141	52	MA1628.1	Zic1::Zic2	MA1628.1	CVCAGCAGGNV	Zic1::Zic2	0.00127	6.56e-06	4030	18.7	8700	17.2	1.08
142	53	MA1557.1	SMAD5	MA1557.1	YGTCTAGACA	SMAD5	0.00156	8.01e-06	11200	52.1	25400	50.3	1.04
143	43	MA1147.1	NR4A2::RXRA	MA1147.1	VRGGTCRTTGACCYY	NR4A2::RXRA	0.00158	8.03e-06	8220	38.2	18400	36.4	1.05
144	54	MA1711.1	ZNF343	MA1711.1	CCGCTTCMCCDCGGCMV	ZNF343	0.00232	1.17e-05	4140	19.2	8990	17.8	1.08
145	55	MA0646.1	GCM1	MA0646.1	BATGCGGGTAC	GCM1	0.00242	1.2e-05	13600	63.4	31100	61.6	1.03
146	56	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	0.00242	1.2e-05	1880	8.75	3900	7.73	1.13
147	3	MA1529.1	NHLH2	MA1529.1	GGGNCGCAGCTGCGYCCC	NHLH2	0.00256	1.26e-05	4780	22.2	10400	20.7	1.07
148	47	MA0142.1 (Pou5f1::Sox2)	STREME-8	8-ATCTGCACTCCCAWG	ATCTGCACTCCCAWG	Pou5f1::Sox2	0.00259	1.27e-05	43	0.2	35	0.07	2.86
149	17	MA0103.3	ZEB1	MA0103.3	SNCACCTGSVN	ZEB1	0.00275	1.34e-05	5670	26.4	12500	24.8	1.06
150	17	MA0636.1	BHLHE41	MA0636.1	RTCACGTGAC	BHLHE41	0.00339	1.64e-05	835	3.88	1620	3.21	1.21
151	17	MA0608.1	Creb3l2	MA0608.1	GCCACGTGD	Creb3l2	0.00382	1.84e-05	2650	12.3	5630	11.2	1.1
152	57	MA1604.1	Ebf2	MA1604.1	NYCCCAAGGGANN	Ebf2	0.00394	1.88e-05	6070	28.2	13400	26.6	1.06
153	26	MA0641.1	ELF4	MA0641.1	AACCCGGAAGTR	ELF4	0.00429	2.03e-05	3980	18.5	8640	17.1	1.08
154	17	MA1945.1	ETV5::FIGLA	MA1945.1	RGCGGAARCAGGTGG	ETV5::FIGLA	0.00431	2.03e-05	4650	21.6	10200	20.1	1.07
155	22	MA0697.2	Zic3	MA0697.2	CNCAGCAGGAGNN	Zic3	0.00489	2.29e-05	4490	20.8	9790	19.4	1.07
156	26	MA1992.1	Ikzf3	MA1992.1	NNRCAGGAAGTGGVN	Ikzf3	0.00549	2.56e-05	12700	59.1	28900	57.4	1.03
157	58	MA2002.1	Zfp335	MA2002.1	VNTCAGGCANH	Zfp335	0.00854	3.95e-05	4860	22.6	10700	21.2	1.07
158	55	MA0767.1	GCM2	MA0767.1	BATGCGGGTR	GCM2	0.00949	4.37e-05	7600	35.3	17000	33.7	1.05
159	59	MA0504.1	NR2C2	MA0504.1	VGRGGTCARAGGTCA	NR2C2	0.0105	4.79e-05	9210	42.8	20700	41.1	1.04
160	57	MA0154.4	EBF1	MA0154.4	NNTCCCCAGGGGANN	EBF1	0.0112	5.09e-05	4430	20.6	9700	19.2	1.07
161	17	MA0822.1	HES7	MA0822.1	YGGCACGTGCCR	HES7	0.0128	5.76e-05	373	1.73	665	1.32	1.32
162	60	MA1715.1	ZNF707	MA1715.1	CCCCACTCCTGGTAC	ZNF707	0.0141	6.28e-05	6650	30.9	14800	29.3	1.05
163	61	MA0738.1	HIC2	MA0738.1	RTGCCCRSB	HIC2	0.0141	6.28e-05	1310	6.08	2680	5.3	1.15
164	62	MA1964.1	SMAD2	MA1964.1	NBCCAGACDN	SMAD2	0.0145	6.44e-05	16500	76.6	37900	75.2	1.02
165	43	MA1535.1	NR2C1	MA1535.1	NRRGGTCAN	NR2C1	0.0149	6.57e-05	15900	73.6	36400	72.1	1.02
166	63	MA1554.1	RFX7	MA1554.1	CGTTGCYAY	RFX7	0.0155	6.8e-05	17800	82.5	41000	81.2	1.02
167	17	MA1493.1	HES6	MA1493.1	GGCACGTGTY	HES6	0.0321	0.00014	9020	41.9	20400	40.3	1.04
168	45	MA1475.1	CREB3L4	MA1475.1	GRTGACGTCAYC	CREB3L4	0.033	0.000143	14400	67	33100	65.5	1.02
11	65	MA1125.1 (ZNF384)	MEME-1	TTTTTTTTTWTTTTT	TTTTTTTTTWTTTTT	ZNF384	0.036	0.00328	734	3.41	1520	3.01	1.13
169	26	MA0098.3	ETS1	MA0098.3	ACCGGAARTR	ETS1	0.0396	0.000171	12700	58.8	28900	57.3	1.03
170	17	MA0499.2	MYOD1	MA0499.2	NNGCACCTGTCNB	MYOD1	0.0424	0.000181	16900	78.5	38900	77.1	1.02
171	64	MA1616.1	Prdm15	MA1616.1	NRGAAAACCTGGAVN	Prdm15	0.0431	0.000183	19100	88.7	44200	87.6	1.01
12	66	MA1135.1 (FOSB::JUNB)	MEME-3	ATGACTCA	ATGACTCA	FOSB::JUNB	12	1	641	2.98	1820	3.61	0.826

ER_rat <- 1.25

DNR_24_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DNR_24_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

DNR_24_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*2), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./2,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DNR_24_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

MTX 3 hour

MTX_3_DAR_DEG_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_3_DEG_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
MTX_3_DAR_DEG_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_3_DEG_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
MTX_3_DAR_DEG_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_3_DEG_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
MTX_3_DAR_DEG_sea_all <- rbind(MTX_3_DAR_DEG_sea_disc, MTX_3_DAR_DEG_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

MTX_3_DAR_DEG_combo <- MTX_3_DAR_DEG_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., MTX_3_DAR_DEG_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

MTX_3_DAR_DEG_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in MTX  v VEH") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in MTX v VEH
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
5	5	5-AGAGGARGGAGATRA	STREME-5	5-AGAGGARGGAGATRA	AGAGGARGGAGATRA	AGAGGARGGAGATRA	0.000325	6.51e-05	2	28.6	0	0	299
1	1	MA1629.1 (Zic2)	STREME-1	1-TCCCAGCASA	TCCCAGCASA	Zic2	0.00162	0.00148	5	71.4	21	2.63	27.2
2	2	3-TAGGCCAS	STREME-3	3-TAGGCCAS	TAGGCCAS	TAGGCCAS	0.0254	0.0101	4	57.1	15	1.88	31.2
3	3	MA1557.1 (SMAD5)	STREME-2	2-CTAGCCA	CTAGCCA	SMAD5	0.0477	0.0101	6	85.7	82	10.3	8.41
4	4	MA0686.1 (SPDEF)	STREME-4	4-AGATCC	AGATCC	SPDEF	0.0493	0.0101	7	100	150	18.8	5.28

ER_rat <- 1.25

MTX_3_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("MTX_3_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

MTX_3_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*.05), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.05,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("MTX_3_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

MTX 24 hour

MTX_24_DAR_DEG_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_24_DEG_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
MTX_24_DAR_DEG_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_24_DEG_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
MTX_24_DAR_DEG_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_24_DEG_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
MTX_24_DAR_DEG_sea_all <- rbind(MTX_24_DAR_DEG_sea_disc, MTX_24_DAR_DEG_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

MTX_24_DAR_DEG_combo <- MTX_24_DAR_DEG_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., MTX_24_DAR_DEG_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) 

MTX_24_DAR_DEG_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in MTX  v VEH") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in MTX v VEH
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO
1	1	MA1995.1 (Npas4)	STREME-1	1-GTCTCGATG	GTCTCGATG	Npas4	0.000272	0.00026	97	7.32	853	4.16	1.77
2	2	MA1489.1 (FOXN3)	STREME-2	2-AGGAAACAAAACTK	AGGAAACAAAACTK	FOXN3	0.00525	0.00263	15	1.13	81	0.4	3.01
2	8	MA0907.1	HOXC13	MA0907.1	BCTCGTAAAAH	HOXC13	0.0208	0.00996	52	3.92	420	2.05	1.94
3	3	MA1511.2 (KLF10)	MEME-4	GSGCGGGGSSSGGGG	GSGCGGGGSSSGGGG	KLF10	0.0622	0.0207	120	9.05	1470	7.18	1.27
4	4	MA1547.2 (PITX2)	MEME-5	TAATCCCARCACTTT	TAATCCCARCACTTT	PITX2	0.339	0.0848	38	2.87	430	2.1	1.4
5	5	MA1107.2 (KLF9)	MEME-1	ACACACACACACACA	ACACACACACACACA	KLF9	1.03	0.207	32	2.41	395	1.93	1.29
6	6	MA0476.1 (FOS)	MEME-2	TGASTCAT	TGASTCAT	FOS	3.51	0.569	22	1.66	323	1.58	1.1
7	7	MA1125.1 (ZNF384)	MEME-3	TTKTTTTTWTTTTTW	TTKTTTTTWTTTTTW	ZNF384	3.99	0.569	1	0.08	10	0.05	2.81
8	8	MA0907.1 (HOXC13)	STREME-3	3-CTCGTAAAGTYS	CTCGTAAAGTYS	HOXC13	6.01	0.752	421	31.8	6690	32.6	0.975

ER_rat <- 1.25

MTX_24_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("MTX_24_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

MTX_24_DAR_DEG_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*.1), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.1,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("MTX_24_DAR_DEG_combo response peaks(200bp)Enrichment ratio:",ER_rat))

DAR_DEG data up/down 24hour set

DOX

DOX 24_up hour

DOX_24_DD_up_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_DEG_24_up_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DOX_24_DD_up_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_DEG_24_up_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DOX_24_DD_up_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_DEG_24_up_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DOX_24_DD_up_sea_all <- rbind(DOX_24_DD_up_sea_disc, DOX_24_DD_up_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DOX_24_DD_up_combo <- DOX_24_DD_up_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DOX_24_DD_up_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="DOX_24_DD_up")

DOX_24_DD_up_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "DOX_24_DD_up DOX enriched motifs") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

DOX_24_DD_up DOX enriched motifs
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA0039.4 (KLF4)	STREME-2	2-MCYCCAGCCTGGSY	MCYCCAGCCTGGSY	KLF4	1.1e-13	8.58e-14	2250	26.7	4620	22.2	1.2	DOX_24_DD_up
2	2	MA1719.1 (ZNF816)	STREME-6	6-GGGACCTG	GGGACCTG	ZNF816	9.39e-12	3.67e-12	4040	47.9	8950	43	1.11	DOX_24_DD_up
3	3	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	3.48e-11	9.06e-12	1710	20.3	3450	16.6	1.22	DOX_24_DD_up
4	4	1-SGSGWCSCS	STREME-1	1-SGSGWCSCS	SGSGWCSCS	SGSGWCSCS	1.78e-10	3.48e-11	4290	50.9	9610	46.2	1.1	DOX_24_DD_up
5	5	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	2.59e-08	4.05e-09	3040	36	6660	32	1.13	DOX_24_DD_up
6	5	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	9.28e-08	1.14e-08	5560	65.8	12900	61.9	1.06	DOX_24_DD_up
7	5	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	1.02e-07	1.14e-08	4280	50.8	9720	46.7	1.09	DOX_24_DD_up
8	5	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	7.17e-07	7e-08	3800	45	8580	41.2	1.09	DOX_24_DD_up
9	6	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	9.44e-07	8.18e-08	1980	23.4	4210	20.2	1.16	DOX_24_DD_up
10	7	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	1.05e-06	8.18e-08	5460	64.7	12700	61	1.06	DOX_24_DD_up
11	8	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	2.46e-06	1.64e-07	4580	54.2	10500	50.5	1.07	DOX_24_DD_up
12	5	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	2.52e-06	1.64e-07	3040	36	6760	32.5	1.11	DOX_24_DD_up
13	6	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	5.28e-06	3.06e-07	2640	31.3	5820	28	1.12	DOX_24_DD_up
14	3	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	5.69e-06	3.06e-07	3020	35.8	6740	32.4	1.11	DOX_24_DD_up
15	5	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	5.87e-06	3.06e-07	4360	51.6	9980	48	1.08	DOX_24_DD_up
16	5	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	6.89e-06	3.36e-07	1140	13.5	2320	11.1	1.22	DOX_24_DD_up
17	6	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	7.35e-06	3.38e-07	2630	31.2	5790	27.8	1.12	DOX_24_DD_up
18	9	MA0682.2 (PITX1)	STREME-3	3-RCCTGTAATCCC	RCCTGTAATCCC	PITX1	8.05e-06	3.5e-07	502	5.95	907	4.36	1.37	DOX_24_DD_up
19	5	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	2.59e-05	1.07e-06	6130	72.7	14500	69.5	1.05	DOX_24_DD_up
20	10	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	3.23e-05	1.26e-06	3120	36.9	7000	33.6	1.1	DOX_24_DD_up
21	3	MA1587.1	ZNF135	MA1587.1	CCTCGACCTCCYRR	ZNF135	3.76e-05	1.4e-06	397	4.7	699	3.36	1.4	DOX_24_DD_up
22	5	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	4.56e-05	1.62e-06	3820	45.3	8710	41.9	1.08	DOX_24_DD_up
23	5	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	5.31e-05	1.75e-06	3960	46.9	9050	43.5	1.08	DOX_24_DD_up
24	28	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	5.37e-05	1.75e-06	3410	40.4	7720	37.1	1.09	DOX_24_DD_up
25	11	MA0145.2	Tfcp2l1	MA0145.2	CCAGYYYVADCCRG	Tfcp2l1	5.85e-05	1.83e-06	5870	69.6	13800	66.4	1.05	DOX_24_DD_up
26	5	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	8.27e-05	2.49e-06	2870	34	6420	30.9	1.1	DOX_24_DD_up
27	5	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	9.64e-05	2.79e-06	4060	48.1	9320	44.8	1.07	DOX_24_DD_up
28	15	MA1581.1	ZBTB6	MA1581.1	DNSCTTGAGCCNV	ZBTB6	0.000155	4.32e-06	5940	70.3	14000	67.3	1.05	DOX_24_DD_up
29	10	MA1648.1	TCF12	MA1648.1	NNCACCTGCNN	TCF12	0.00019	5.12e-06	6100	72.3	14400	69.4	1.04	DOX_24_DD_up
30	7	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	0.000223	5.6e-06	3010	35.7	6790	32.6	1.09	DOX_24_DD_up
31	12	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	0.000224	5.6e-06	3950	46.8	9080	43.6	1.07	DOX_24_DD_up
32	5	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	0.000235	5.6e-06	6080	72	14400	69	1.04	DOX_24_DD_up
33	5	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	0.000236	5.6e-06	6140	72.7	14500	69.8	1.04	DOX_24_DD_up
34	5	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	3e-04	6.9e-06	4910	58.2	11400	55	1.06	DOX_24_DD_up
35	5	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	0.000315	6.97e-06	4010	47.5	9230	44.3	1.07	DOX_24_DD_up
36	7	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	0.000329	6.97e-06	1840	21.8	4000	19.2	1.13	DOX_24_DD_up
37	13	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	0.00033	6.97e-06	3270	38.7	7420	35.7	1.09	DOX_24_DD_up
38	6	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	0.000505	1.04e-05	2750	32.6	6170	29.6	1.1	DOX_24_DD_up
39	5	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	0.000629	1.26e-05	4640	55	10800	51.9	1.06	DOX_24_DD_up
6	27	5-ACAGAGCAAGACYC	STREME-5	5-ACAGAGCAAGACYC	ACAGAGCAAGACYC	ACAGAGCAAGACYC	0.000779	0.00013	124	1.47	198	0.95	1.55	DOX_24_DD_up
40	5	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	0.000793	1.55e-05	4180	49.5	9670	46.5	1.07	DOX_24_DD_up
41	14	MA0736.1	GLIS2	MA0736.1	GACCCCCCGCRAMG	GLIS2	0.00127	2.42e-05	2460	29.2	5520	26.5	1.1	DOX_24_DD_up
42	15	4-CTCCTGGGCTCAAG	STREME-4	4-CTCCTGGGCTCAAG	CTCCTGGGCTCAAG	CTCCTGGGCTCAAG	0.00194	3.61e-05	5540	65.6	13100	62.7	1.05	DOX_24_DD_up
43	5	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	0.00216	3.92e-05	3320	39.3	7590	36.4	1.08	DOX_24_DD_up
44	5	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	0.00221	3.92e-05	1490	17.7	3220	15.5	1.14	DOX_24_DD_up
45	7	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	0.00343	5.96e-05	2600	30.8	5870	28.2	1.09	DOX_24_DD_up
46	5	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	0.0045	7.65e-05	5610	66.5	13300	63.7	1.04	DOX_24_DD_up
47	5	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	0.00472	7.85e-05	4420	52.4	10300	49.5	1.06	DOX_24_DD_up
48	5	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	0.00717	0.000115	4140	49	9620	46.2	1.06	DOX_24_DD_up
49	5	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	0.00722	0.000115	3380	40	7770	37.3	1.07	DOX_24_DD_up
50	16	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	0.00829	0.00013	4580	54.3	10700	51.5	1.05	DOX_24_DD_up
51	7	MA1719.1	ZNF816	MA1719.1	DRRKGGGGACATGCHGGG	ZNF816	0.00977	0.00015	3780	44.7	8750	42	1.06	DOX_24_DD_up
52	17	MA0511.2	RUNX2	MA0511.2	WAACCGCAA	RUNX2	0.0102	0.000153	4960	58.8	11700	56.1	1.05	DOX_24_DD_up
53	5	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	0.0115	0.00017	5960	70.6	14200	68.1	1.04	DOX_24_DD_up
54	18	MA1728.1	ZNF549	MA1728.1	NNTGCTGCCCWR	ZNF549	0.0128	0.000185	1480	17.6	3240	15.6	1.13	DOX_24_DD_up
55	28	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	0.0153	0.000217	4460	52.8	10400	50.2	1.05	DOX_24_DD_up
56	14	MA0751.1	ZIC4	MA0751.1	GRCCCCCCGCKGYGH	ZIC4	0.0169	0.000237	5220	61.8	12300	59.2	1.04	DOX_24_DD_up
57	19	MA1973.1	ZKSCAN3	MA1973.1	KDKCCCAGGCTAGCCCABNN	ZKSCAN3	0.0179	0.000246	3400	40.2	7840	37.7	1.07	DOX_24_DD_up
58	20	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	0.0197	0.000266	3790	44.9	8800	42.3	1.06	DOX_24_DD_up
59	5	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	0.0214	0.000279	1700	20.2	3770	18.1	1.11	DOX_24_DD_up
60	5	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	0.0214	0.000279	3900	46.3	9090	43.6	1.06	DOX_24_DD_up
61	21	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	0.0234	0.000298	2200	26.1	4960	23.8	1.09	DOX_24_DD_up
62	22	MA1987.1	ZNF701	MA1987.1	GAGCACYAARGGGGGRADDDD	ZNF701	0.0236	0.000298	1870	22.2	4180	20.1	1.11	DOX_24_DD_up
63	23	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	0.0251	0.000309	1820	21.6	4050	19.5	1.11	DOX_24_DD_up
64	5	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	0.0253	0.000309	2400	28.4	5430	26.1	1.09	DOX_24_DD_up
65	24	MA1555.1	RXRB	MA1555.1	RRGGTCATGACCYY	RXRB	0.031	0.000373	3430	40.7	7950	38.2	1.07	DOX_24_DD_up
66	25	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	0.0329	0.000386	1320	15.6	2870	13.8	1.13	DOX_24_DD_up
67	16	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	0.033	0.000386	4700	55.7	11100	53.1	1.05	DOX_24_DD_up
68	26	MA0820.1	FIGLA	MA0820.1	WMCACCTGKW	FIGLA	0.0425	0.000489	5970	70.7	14200	68.4	1.03	DOX_24_DD_up
7	28	MA1130.1 (FOSL2::JUN)	MEME-1	DKNATGAGTCAYH	DKNATGAGTCAYH	FOSL2::JUN	4.48	0.639	225	2.67	569	2.73	0.978	DOX_24_DD_up

ER_rat <- 1.25

DOX_24_DD_up_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DOX_24_DD_up_combo response peaks(200bp)Enrichment ratio:",ER_rat))

DOX_24_DD_up_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DOX_24_DD_up_combo response peaks(200bp)Enrichment ratio:",ER_rat))

DOX 24_down hour

DOX_24_DD_down_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_DEG_24_down_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DOX_24_DD_down_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_DEG_24_down_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DOX_24_DD_down_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DOX_DEG_24_down_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DOX_24_DD_down_sea_all <- rbind(DOX_24_DD_down_sea_disc, DOX_24_DD_down_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DOX_24_DD_down_combo <- DOX_24_DD_down_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DOX_24_DD_down_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="DOX_24_DD_down")

DOX_24_DD_down_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "DOX_24_DD_down DOX enriched motifs") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

DOX_24_DD_down DOX enriched motifs
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	1.86e-70	1.33e-70	1600	19.6	1310	10.5	1.86	DOX_24_DD_down
2	2	MA0742.2 (KLF12)	STREME-2	2-CCCGCCCCGCCCC	CCCGCCCCGCCCC	KLF12	3.28e-63	1.17e-63	2930	35.9	3070	24.7	1.45	DOX_24_DD_down
3	2	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	8.38e-63	2e-63	2390	29.3	2360	19	1.54	DOX_24_DD_down
4	1	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	7.4e-58	1.33e-58	2500	30.7	2550	20.5	1.49	DOX_24_DD_down
5	3	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	5.23e-56	7.5e-57	2520	30.8	2590	20.8	1.48	DOX_24_DD_down
6	4	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	2.38e-53	2.84e-54	1090	13.4	841	6.76	1.98	DOX_24_DD_down
7	5	3-CCGSSCGG	STREME-3	3-CCGSSCGG	CCGSSCGG	CCGSSCGG	6.73e-53	6.89e-54	3810	46.7	4450	35.7	1.31	DOX_24_DD_down
8	6	MA1961.1 (PATZ1)	STREME-1	1-CCGCCGCCKCBSS	CCGCCGCCKCBSS	PATZ1	3.5e-52	3.13e-53	3340	40.9	3770	30.3	1.35	DOX_24_DD_down
9	7	4-CSCGSG	STREME-4	4-CSCGSG	CSCGSG	CSCGSG	4.52e-52	3.6e-53	1980	24.2	1920	15.4	1.57	DOX_24_DD_down
10	8	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	2.16e-50	1.54e-51	2660	32.6	2850	22.9	1.42	DOX_24_DD_down
11	9	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	1.91e-45	1.25e-46	2770	34	3060	24.6	1.38	DOX_24_DD_down
12	2	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	2.46e-45	1.47e-46	1830	22.4	1800	14.4	1.55	DOX_24_DD_down
13	2	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	2.8e-45	1.54e-46	2170	26.5	2240	18	1.48	DOX_24_DD_down
14	10	MA1713.1 (ZNF610)	STREME-7	7-CCGCTCC	CCGCTCC	ZNF610	3.06e-45	1.57e-46	2260	27.7	2360	19	1.46	DOX_24_DD_down
15	1	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	8.09e-45	3.86e-46	1730	21.2	1670	13.4	1.58	DOX_24_DD_down
16	2	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	1.06e-43	4.74e-45	2780	34	3080	24.8	1.37	DOX_24_DD_down
17	11	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	1.67e-43	7.04e-45	1850	22.6	1840	14.8	1.53	DOX_24_DD_down
18	4	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	4.42e-43	1.76e-44	2820	34.5	3150	25.3	1.36	DOX_24_DD_down
19	9	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	1.06e-42	3.99e-44	3080	37.7	3510	28.2	1.33	DOX_24_DD_down
20	4	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	2.91e-42	1.04e-43	1480	18.1	1380	11.1	1.63	DOX_24_DD_down
21	9	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	1.75e-41	5.98e-43	4460	54.6	5560	44.7	1.22	DOX_24_DD_down
22	2	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	5.1e-41	1.66e-42	1640	20.1	1600	12.8	1.57	DOX_24_DD_down
23	9	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	6.75e-41	2.1e-42	1750	21.4	1740	14	1.53	DOX_24_DD_down
24	4	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	1.41e-40	4.19e-42	4130	50.6	5080	40.8	1.24	DOX_24_DD_down
25	12	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	4.49e-40	1.29e-41	1200	14.7	1060	8.54	1.72	DOX_24_DD_down
26	4	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	2.1e-39	5.78e-41	1240	15.2	1110	8.94	1.7	DOX_24_DD_down
27	13	MA1615.1 (Plagl1)	STREME-6	6-AGGCCCCAGC	AGGCCCCAGC	Plagl1	2.31e-39	6.12e-41	2050	25.2	2150	17.3	1.45	DOX_24_DD_down
28	12	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	3.8e-37	9.71e-39	2870	35.2	3300	26.5	1.33	DOX_24_DD_down
29	12	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	1.27e-36	3.14e-38	1370	16.8	1300	10.5	1.61	DOX_24_DD_down
30	12	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	8.35e-36	1.99e-37	3540	43.3	4270	34.4	1.26	DOX_24_DD_down
31	13	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	1.49e-35	3.43e-37	2660	32.5	3020	24.3	1.34	DOX_24_DD_down
32	14	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	1.54e-35	3.44e-37	839	10.3	673	5.41	1.9	DOX_24_DD_down
33	15	MA1985.1	ZNF669	MA1985.1	GGGGYGAYGACCRCT	ZNF669	2.21e-35	4.8e-37	2640	32.4	3010	24.2	1.34	DOX_24_DD_down
34	9	MA0024.3	E2F1	MA0024.3	TTTGGCGCCAAA	E2F1	5.48e-35	1.15e-36	1400	17.2	1360	10.9	1.58	DOX_24_DD_down
35	16	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	1.8e-34	3.69e-36	3290	40.3	3930	31.6	1.27	DOX_24_DD_down
36	17	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	3.12e-34	6.2e-36	448	5.49	265	2.13	2.57	DOX_24_DD_down
37	12	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	1.01e-33	1.96e-35	4650	56.9	5970	48	1.19	DOX_24_DD_down
38	4	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	1.46e-33	2.76e-35	2040	24.9	2200	17.6	1.41	DOX_24_DD_down
39	18	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	2.42e-33	4.45e-35	3400	41.7	4110	33	1.26	DOX_24_DD_down
40	19	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	3.63e-33	6.5e-35	4390	53.8	5590	44.9	1.2	DOX_24_DD_down
41	20	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	1.33e-32	2.33e-34	1020	12.5	907	7.29	1.71	DOX_24_DD_down
42	21	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	3.9e-32	6.65e-34	3460	42.4	4220	33.9	1.25	DOX_24_DD_down
43	9	MA0864.2	E2F2	MA0864.2	RWTTTGGCGCCAWWWY	E2F2	8.13e-32	1.35e-33	2340	28.7	2640	21.2	1.35	DOX_24_DD_down
44	22	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	9.76e-32	1.59e-33	3900	47.8	4880	39.2	1.22	DOX_24_DD_down
45	4	MA0732.1	EGR3	MA0732.1	HHMCGCCCACGCAHH	EGR3	4.42e-31	7.03e-33	788	9.65	647	5.2	1.86	DOX_24_DD_down
46	2	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	5.44e-31	8.48e-33	1380	16.9	1370	11	1.54	DOX_24_DD_down
47	31	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	9.08e-31	1.38e-32	3460	42.4	4240	34.1	1.24	DOX_24_DD_down
48	4	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	2.19e-29	3.27e-31	3930	48.2	4960	39.9	1.21	DOX_24_DD_down
49	23	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	1.13e-28	1.66e-30	1270	15.6	1250	10.1	1.55	DOX_24_DD_down
50	22	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	1.16e-28	1.66e-30	767	9.39	641	5.15	1.82	DOX_24_DD_down
51	24	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	5.29e-27	7.42e-29	4770	58.4	6270	50.4	1.16	DOX_24_DD_down
52	25	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	5.76e-27	7.94e-29	3340	41	4130	33.2	1.23	DOX_24_DD_down
53	26	MA1578.1	VEZF1	MA1578.1	CCCCCCMYDH	VEZF1	5.98e-27	8.08e-29	4140	50.7	5310	42.7	1.19	DOX_24_DD_down
54	9	MA0470.2	E2F4	MA0470.2	TTTTGGCGCCAWWW	E2F4	1.06e-26	1.4e-28	1610	19.7	1710	13.7	1.43	DOX_24_DD_down
55	27	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	3.48e-26	4.53e-28	3620	44.3	4550	36.5	1.21	DOX_24_DD_down
56	28	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	4.74e-26	6.06e-28	3090	37.8	3770	30.3	1.25	DOX_24_DD_down
57	29	MA0694.1	ZBTB7B	MA0694.1	RCGACCACCGAA	ZBTB7B	7.2e-26	9.05e-28	3820	46.8	4850	39	1.2	DOX_24_DD_down
58	12	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	3.88e-25	4.79e-27	778	9.53	682	5.48	1.74	DOX_24_DD_down
59	30	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	4.98e-25	6.05e-27	968	11.9	912	7.33	1.62	DOX_24_DD_down
60	9	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	1.38e-24	1.64e-26	796	9.75	708	5.69	1.71	DOX_24_DD_down
61	12	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	1.87e-24	2.2e-26	875	10.7	804	6.46	1.66	DOX_24_DD_down
62	23	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	3.82e-24	4.41e-26	1510	18.5	1610	13	1.43	DOX_24_DD_down
63	19	MA0528.2	ZNF263	MA0528.2	VNGGGGAGGASG	ZNF263	1.09e-23	1.24e-25	5360	65.7	7260	58.3	1.13	DOX_24_DD_down
64	31	MA0039.4 (KLF4)	STREME-5	5-CCCACCCC	CCCACCCC	KLF4	2.02e-23	2.26e-25	2870	35.2	3510	28.2	1.25	DOX_24_DD_down
65	32	MA0751.1	ZIC4	MA0751.1	GRCCCCCCGCKGYGH	ZIC4	4.01e-23	4.41e-25	1100	13.5	1100	8.81	1.53	DOX_24_DD_down
66	33	MA1727.1	ZNF417	MA1727.1	VRBVNTGGGCGCCAM	ZNF417	4.5e-23	4.88e-25	3360	41.2	4230	34	1.21	DOX_24_DD_down
67	2	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	5.4e-23	5.77e-25	664	8.13	566	4.55	1.79	DOX_24_DD_down
68	34	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	7.6e-23	8.01e-25	5670	69.4	7760	62.3	1.11	DOX_24_DD_down
69	35	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	7.85e-23	8.15e-25	3080	37.7	3820	30.7	1.23	DOX_24_DD_down
70	14	MA1569.1	TFAP2E	MA1569.1	YGCCYSRGGCD	TFAP2E	1.11e-22	1.14e-24	1060	12.9	1040	8.39	1.54	DOX_24_DD_down
71	12	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	1.22e-22	1.23e-24	1020	12.5	1000	8.06	1.55	DOX_24_DD_down
72	29	MA0695.1	ZBTB7C	MA0695.1	RCGACCACCGAN	ZBTB7C	1.46e-22	1.45e-24	3320	40.6	4170	33.5	1.21	DOX_24_DD_down
73	23	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	2.3e-22	2.26e-24	599	7.34	496	3.99	1.84	DOX_24_DD_down
74	4	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	2.93e-22	2.83e-24	881	10.8	832	6.69	1.61	DOX_24_DD_down
75	36	MA0615.1	Gmeb1	MA0615.1	BHBBKKACGTMMNWNNN	Gmeb1	1.92e-21	1.83e-23	2370	29	2830	22.7	1.28	DOX_24_DD_down
76	26	MA1987.1	ZNF701	MA1987.1	GAGCACYAARGGGGGRADDDD	ZNF701	1.99e-21	1.88e-23	4310	52.8	5680	45.6	1.16	DOX_24_DD_down
77	12	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	6.18e-21	5.74e-23	889	10.9	855	6.87	1.58	DOX_24_DD_down
78	11	MA1930.1	CTCF	MA1930.1	CTGCAGTKCCNVCHNNYRGCCASYAGRKGGCRAKC	CTCF	1.75e-20	1.61e-22	2040	24.9	2380	19.1	1.3	DOX_24_DD_down
79	14	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	2.01e-20	1.82e-22	1850	22.7	2130	17.1	1.33	DOX_24_DD_down
80	23	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	2.26e-20	2.02e-22	2380	29.2	2860	23	1.27	DOX_24_DD_down
81	32	MA1584.1	ZIC5	MA1584.1	VGACCCCCCGCTGHGM	ZIC5	7.65e-20	6.77e-22	1600	19.6	1790	14.4	1.36	DOX_24_DD_down
82	23	MA1106.1	HIF1A	MA1106.1	SBACGTGCNN	HIF1A	8.32e-20	7.26e-22	2840	34.7	3520	28.3	1.23	DOX_24_DD_down
83	34	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	9.37e-20	8.09e-22	5530	67.8	7610	61.1	1.11	DOX_24_DD_down
84	34	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	3.79e-19	3.23e-21	6130	75	8570	68.9	1.09	DOX_24_DD_down
85	37	MA1966.1	TFAP4::ETV1	MA1966.1	RSCGGAAGCAGSTGKN	TFAP4::ETV1	4.1e-19	3.46e-21	1600	19.6	1800	14.5	1.35	DOX_24_DD_down
86	23	MA0259.1	ARNT::HIF1A	MA0259.1	VBACGTGC	ARNT::HIF1A	8.31e-19	6.92e-21	2740	33.6	3400	27.4	1.23	DOX_24_DD_down
87	38	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	1.07e-18	8.78e-21	4200	51.4	5560	44.7	1.15	DOX_24_DD_down
88	12	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	1.73e-18	1.41e-20	813	9.96	786	6.32	1.58	DOX_24_DD_down
89	37	MA1941.1	ETV2::FIGLA	MA1941.1	RSCGGAARCAGSTGBN	ETV2::FIGLA	2.61e-18	2.1e-20	2520	30.9	3100	24.9	1.24	DOX_24_DD_down
90	23	MA1099.2	HES1	MA1099.2	GGCRCGTGBC	HES1	5.31e-18	4.22e-20	253	3.1	152	1.22	2.53	DOX_24_DD_down
91	14	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	5.77e-18	4.54e-20	1720	21.1	1990	16	1.32	DOX_24_DD_down
92	39	MA1971.1	ZBED2	MA1971.1	NNMMCGAAACCNNV	ZBED2	8.7e-18	6.77e-20	4020	49.2	5300	42.6	1.15	DOX_24_DD_down
93	76	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	1.29e-17	9.96e-20	762	9.33	732	5.88	1.59	DOX_24_DD_down
94	29	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	1.17e-16	8.94e-19	5550	68	7700	61.9	1.1	DOX_24_DD_down
95	34	MA0872.1	TFAP2A	MA0872.1	TGCCCYSRGGGCA	TFAP2A	1.3e-16	9.77e-19	752	9.21	730	5.87	1.57	DOX_24_DD_down
96	26	MA0736.1	GLIS2	MA0736.1	GACCCCCCGCRAMG	GLIS2	2.1e-16	1.57e-18	1570	19.2	1800	14.5	1.33	DOX_24_DD_down
97	40	MA1719.1	ZNF816	MA1719.1	DRRKGGGGACATGCHGGG	ZNF816	3.29e-16	2.43e-18	4200	51.4	5610	45.1	1.14	DOX_24_DD_down
98	41	MA0597.2	THAP1	MA0597.2	VSGCAGGGCASV	THAP1	3.6e-16	2.63e-18	5870	71.9	8220	66	1.09	DOX_24_DD_down
99	29	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	2.29e-15	1.66e-17	6260	76.7	8870	71.3	1.08	DOX_24_DD_down
100	42	MA1684.1	Foxn1	MA1684.1	RGAMGC	Foxn1	3.16e-15	2.26e-17	624	7.64	587	4.72	1.62	DOX_24_DD_down
101	4	MA1656.1	ZNF449	MA1656.1	NNAAGCCCAACCNN	ZNF449	5.58e-15	3.96e-17	4840	59.3	6630	53.3	1.11	DOX_24_DD_down
102	23	MA0649.1	HEY2	MA0649.1	GRCACGTGYC	HEY2	7.17e-15	5.03e-17	1140	14	1250	10.1	1.39	DOX_24_DD_down
103	11	MA1929.1	CTCF	MA1929.1	CTGCAGTKCCNNNNNYNRCCASYAGRKGGCRSWG	CTCF	1.88e-14	1.31e-16	1240	15.1	1380	11.1	1.36	DOX_24_DD_down
104	43	MA1710.1	ZNF257	MA1710.1	VDGAGGCRAGRG	ZNF257	2.39e-14	1.65e-16	4870	59.7	6690	53.8	1.11	DOX_24_DD_down
105	44	MA1973.1	ZKSCAN3	MA1973.1	KDKCCCAGGCTAGCCCABNN	ZKSCAN3	7.38e-13	5.03e-15	1410	17.2	1640	13.2	1.31	DOX_24_DD_down
106	23	MA0616.2	HES2	MA0616.2	GGCACGTGYC	HES2	1.09e-12	7.38e-15	264	3.23	192	1.54	2.09	DOX_24_DD_down
107	23	MA0104.4	MYCN	MA0104.4	VVCCACGTGGBB	MYCN	2.25e-12	1.51e-14	1340	16.4	1560	12.5	1.31	DOX_24_DD_down
108	23	MA0147.3	MYC	MA0147.3	NNCCACGTGCNB	MYC	5.16e-12	3.42e-14	945	11.6	1030	8.3	1.39	DOX_24_DD_down
109	45	MA0163.1	PLAG1	MA0163.1	GGGGCCCWAGGGGG	PLAG1	9.14e-12	6e-14	959	11.8	1060	8.48	1.39	DOX_24_DD_down
110	32	MA1629.1	Zic2	MA1629.1	NDCACAGCAGGDRG	Zic2	2.6e-11	1.69e-13	5130	62.8	7160	57.6	1.09	DOX_24_DD_down
111	23	MA1631.1	ASCL1	MA1631.1	NNGCACCTGCYNB	ASCL1	2.68e-11	1.73e-13	1390	17	1640	13.2	1.29	DOX_24_DD_down
112	11	MA0139.1	CTCF	MA0139.1	YGRCCASYAGRKGGCRSYR	CTCF	4.95e-11	3.16e-13	4640	56.9	6420	51.6	1.1	DOX_24_DD_down
113	11	MA0155.1	INSM1	MA0155.1	TGYCWGGGGGCR	INSM1	2.31e-10	1.46e-12	2470	30.2	3190	25.6	1.18	DOX_24_DD_down
114	46	MA1716.1	ZNF76	MA1716.1	NNTWCCCAYAATGCAHYGCGC	ZNF76	4.68e-10	2.94e-12	1360	16.7	1620	13.1	1.28	DOX_24_DD_down
115	34	MA0815.1	TFAP2C	MA0815.1	TGCCCYSRGGGCA	TFAP2C	9.17e-10	5.71e-12	431	5.28	407	3.27	1.61	DOX_24_DD_down
116	47	MA1637.1	EBF3	MA1637.1	NYCCCAAGGGANN	EBF3	9.74e-10	6.02e-12	5510	67.5	7800	62.7	1.08	DOX_24_DD_down
117	48	MA0511.2	RUNX2	MA0511.2	WAACCGCAA	RUNX2	1.12e-09	6.84e-12	5970	73.2	8540	68.6	1.07	DOX_24_DD_down
118	49	MA1933.1	ELK1::SREBF2	MA1933.1	DCCGGAAGTSRCGTGA	ELK1::SREBF2	1.22e-09	7.38e-12	1550	19	1890	15.2	1.25	DOX_24_DD_down
119	34	MA0813.1	TFAP2B	MA0813.1	TGCCCYBRGGGCA	TFAP2B	1.44e-09	8.69e-12	501	6.14	495	3.98	1.54	DOX_24_DD_down
120	50	MA1982.1	ZNF574	MA1982.1	VGSCTAGAGMGGCCS	ZNF574	2.01e-09	1.2e-11	5240	64.2	7390	59.4	1.08	DOX_24_DD_down
121	51	MA1545.1	OVOL2	MA1545.1	DDACCGTTABNYN	OVOL2	2.35e-09	1.39e-11	1400	17.2	1700	13.6	1.26	DOX_24_DD_down
122	38	MA0067.2	PAX2	MA0067.2	BCAVTSRAGCGTGACGR	PAX2	4e-09	2.35e-11	424	5.19	405	3.25	1.6	DOX_24_DD_down
123	49	MA0028.2	ELK1	MA0028.2	ACCGGAAGTR	ELK1	4.3e-09	2.51e-11	3340	40.9	4500	36.2	1.13	DOX_24_DD_down
124	37	MA0764.3	ETV4	MA0764.3	ACCGGAAGTR	ETV4	5.25e-09	3.03e-11	5490	67.2	7790	62.6	1.07	DOX_24_DD_down
125	32	MA0696.1	ZIC1	MA0696.1	GACCCCCYGCTGTG	ZIC1	5.91e-09	3.39e-11	614	7.52	645	5.18	1.45	DOX_24_DD_down
126	23	MA1474.1	CREB3L4	MA1474.1	YGCCACGTCAYC	CREB3L4	6.46e-09	3.67e-11	5510	67.4	7820	62.9	1.07	DOX_24_DD_down
127	52	MA1964.1	SMAD2	MA1964.1	NBCCAGACDN	SMAD2	9.47e-09	5.34e-11	7120	87.2	10400	83.8	1.04	DOX_24_DD_down
128	49	MA0765.3	ETV5	MA0765.3	ACCGGAAGTR	ETV5	1.29e-08	7.21e-11	1360	16.6	1650	13.2	1.25	DOX_24_DD_down
129	37	MA0750.2	ZBTB7A	MA0750.2	NVCCGGAAGTGSV	ZBTB7A	2.02e-08	1.12e-10	362	4.43	337	2.71	1.64	DOX_24_DD_down
130	23	MA0464.2	BHLHE40	MA0464.2	VKCACGTGMC	BHLHE40	2.44e-08	1.34e-10	1420	17.4	1740	14	1.24	DOX_24_DD_down
131	49	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	4.5e-08	2.46e-10	688	8.43	753	6.05	1.39	DOX_24_DD_down
132	53	MA0145.2	Tfcp2l1	MA0145.2	CCAGYYYVADCCRG	Tfcp2l1	5.16e-08	2.8e-10	2090	25.6	2700	21.7	1.18	DOX_24_DD_down
133	20	MA1728.1	ZNF549	MA1728.1	NNTGCTGCCCWR	ZNF549	6.69e-08	3.6e-10	2890	35.4	3870	31.1	1.14	DOX_24_DD_down
134	37	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	6.86e-08	3.66e-10	2420	29.6	3180	25.6	1.16	DOX_24_DD_down
135	54	MA1730.1	ZNF708	MA1730.1	NNRGCTGTRCCTCCY	ZNF708	1.02e-07	5.44e-10	2600	31.9	3460	27.8	1.15	DOX_24_DD_down
136	55	MA1557.1	SMAD5	MA1557.1	YGTCTAGACA	SMAD5	1.54e-07	8.13e-10	2280	28	2990	24	1.16	DOX_24_DD_down
137	37	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	3.62e-07	1.89e-09	2390	29.2	3150	25.3	1.15	DOX_24_DD_down
138	56	MA1555.1	RXRB	MA1555.1	RRGGTCATGACCYY	RXRB	1.31e-06	6.77e-09	2560	31.4	3420	27.5	1.14	DOX_24_DD_down
139	36	MA1475.1	CREB3L4	MA1475.1	GRTGACGTCAYC	CREB3L4	2.34e-06	1.2e-08	1360	16.7	1700	13.7	1.22	DOX_24_DD_down
140	37	MA1945.1	ETV5::FIGLA	MA1945.1	RGCGGAARCAGGTGG	ETV5::FIGLA	2.63e-06	1.35e-08	1090	13.3	1320	10.6	1.25	DOX_24_DD_down
141	37	MA1934.1	ERF::FIGLA	MA1934.1	RCCGGAARCASCTGBN	ERF::FIGLA	3.3e-06	1.67e-08	1770	21.7	2290	18.4	1.18	DOX_24_DD_down
142	57	MA1533.1	NR1I2	MA1533.1	DYGAACTSVDTGAACTC	NR1I2	3.64e-06	1.84e-08	4430	54.3	6240	50.2	1.08	DOX_24_DD_down
143	38	MA1995.1	Npas4	MA1995.1	NNTCGTGACHN	Npas4	4.58e-06	2.3e-08	4920	60.2	7000	56.2	1.07	DOX_24_DD_down
144	23	MA1464.1	ARNT2	MA1464.1	GTCACGTGMN	ARNT2	5.68e-06	2.83e-08	964	11.8	1160	9.32	1.27	DOX_24_DD_down
145	27	MA0006.1	Ahr::Arnt	MA0006.1	YGCGTG	Ahr::Arnt	9.08e-06	4.48e-08	344	4.21	343	2.76	1.53	DOX_24_DD_down
146	47	MA1604.1	Ebf2	MA1604.1	NYCCCAAGGGANN	Ebf2	1.05e-05	5.15e-08	4930	60.4	7020	56.4	1.07	DOX_24_DD_down
147	8	MA1587.1	ZNF135	MA1587.1	CCTCGACCTCCYRR	ZNF135	1.09e-05	5.3e-08	659	8.07	752	6.04	1.34	DOX_24_DD_down
148	47	MA0154.4	EBF1	MA0154.4	NNTCCCCAGGGGANN	EBF1	1.59e-05	7.71e-08	6120	75	8900	71.5	1.05	DOX_24_DD_down
149	58	MA1652.1	ZKSCAN5	MA1652.1	NNRGGARGTGAGRR	ZKSCAN5	1.7e-05	8.17e-08	4070	49.9	5720	46	1.09	DOX_24_DD_down
150	56	MA1149.1	RARA::RXRG	MA1149.1	RRGGTCAHNNNRRGGTCA	RARA::RXRG	2.29e-05	1.1e-07	6560	80.3	9600	77.1	1.04	DOX_24_DD_down
151	59	MA1711.1	ZNF343	MA1711.1	CCGCTTCMCCDCGGCMV	ZNF343	4.06e-05	1.92e-07	309	3.78	307	2.47	1.53	DOX_24_DD_down
152	60	MA1726.1	ZNF331	MA1726.1	NMYTGCAGAGCCCH	ZNF331	4.07e-05	1.92e-07	5530	67.8	7980	64.2	1.06	DOX_24_DD_down
153	61	8-RGMCTCGD	STREME-8	8-RGMCTCGD	RGMCTCGD	RGMCTCGD	5.35e-05	2.51e-07	145	1.78	114	0.92	1.93	DOX_24_DD_down
154	23	MA0103.3	ZEB1	MA0103.3	SNCACCTGSVN	ZEB1	6.38e-05	2.97e-07	5100	62.5	7320	58.8	1.06	DOX_24_DD_down
155	23	MA0004.1	Arnt	MA0004.1	CACGTG	Arnt	9.68e-05	4.47e-07	1850	22.7	2450	19.7	1.15	DOX_24_DD_down
156	49	MA1992.1	Ikzf3	MA1992.1	NNRCAGGAAGTGGVN	Ikzf3	0.000106	4.88e-07	5980	73.2	8690	69.9	1.05	DOX_24_DD_down
157	62	MA0159.1	RARA::RXRA	MA0159.1	RGKTCANVGRSAGGTCA	RARA::RXRA	0.000135	6.14e-07	3580	43.8	5000	40.2	1.09	DOX_24_DD_down
158	63	MA0767.1	GCM2	MA0767.1	BATGCGGGTR	GCM2	0.000156	7.09e-07	7650	93.7	11400	91.8	1.02	DOX_24_DD_down
159	23	MA1560.1	SOHLH2	MA1560.1	YGCACGTGCN	SOHLH2	0.00017	7.68e-07	586	7.18	675	5.42	1.32	DOX_24_DD_down
160	23	MA0608.1	Creb3l2	MA0608.1	GCCACGTGD	Creb3l2	0.000178	7.95e-07	2020	24.8	2700	21.7	1.14	DOX_24_DD_down
161	64	MA1542.1	OSR1	MA1542.1	HGCTACYGTD	OSR1	0.000257	1.14e-06	6220	76.2	9090	73.1	1.04	DOX_24_DD_down
162	65	MA0138.2	REST	MA0138.2	TTCAGCACCATGGACAGCDCC	REST	0.000549	2.43e-06	1480	18.2	1940	15.6	1.17	DOX_24_DD_down
163	37	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	0.00066	2.9e-06	2220	27.1	3000	24.2	1.12	DOX_24_DD_down
164	23	MA0663.1	MLX	MA0663.1	RTCACGTGAT	MLX	0.00132	5.74e-06	2360	28.9	3220	25.9	1.11	DOX_24_DD_down
165	66	MA1554.1	RFX7	MA1554.1	CGTTGCYAY	RFX7	0.00145	6.28e-06	699	8.56	846	6.8	1.26	DOX_24_DD_down
166	37	MA1485.1	FERD3L	MA1485.1	GCRMCAGCTGTYAC	FERD3L	0.00175	7.54e-06	1380	17	1810	14.6	1.16	DOX_24_DD_down
167	67	MA1979.1	ZNF416	MA1979.1	TATCTGGGCAH	ZNF416	0.00177	7.59e-06	6380	78.2	9380	75.4	1.04	DOX_24_DD_down
168	68	MA1616.1	Prdm15	MA1616.1	NRGAAAACCTGGAVN	Prdm15	0.00232	9.87e-06	5080	62.2	7350	59.1	1.05	DOX_24_DD_down
169	37	MA1635.1	BHLHE22	MA1635.1	NVCAGCTGBN	BHLHE22	0.00236	1e-05	2230	27.3	3040	24.4	1.12	DOX_24_DD_down
170	56	MA1536.1	NR2C2	MA1536.1	RRGGTCAN	NR2C2	0.00239	1e-05	184	2.25	173	1.39	1.62	DOX_24_DD_down
171	63	MA0646.1	GCM1	MA0646.1	BATGCGGGTAC	GCM1	0.00416	1.74e-05	1530	18.7	2030	16.3	1.15	DOX_24_DD_down
172	37	MA0076.2	ELK4	MA0076.2	BCRCTTCCGGB	ELK4	0.00429	1.79e-05	229	2.8	231	1.86	1.51	DOX_24_DD_down
173	69	MA1628.1	Zic1::Zic2	MA1628.1	CVCAGCAGGNV	Zic1::Zic2	0.00433	1.79e-05	7280	89.2	10800	87.1	1.02	DOX_24_DD_down
174	70	MA0738.1	HIC2	MA0738.1	RTGCCCRSB	HIC2	0.00469	1.93e-05	4300	52.6	6160	49.5	1.06	DOX_24_DD_down
175	23	MA1648.1	TCF12	MA1648.1	NNCACCTGCNN	TCF12	0.00532	2.18e-05	7730	94.6	11600	93.1	1.02	DOX_24_DD_down
176	23	MA0636.1	BHLHE41	MA0636.1	RTCACGTGAC	BHLHE41	0.0058	2.36e-05	265	3.25	278	2.23	1.45	DOX_24_DD_down
177	23	MA0822.1	HES7	MA0822.1	YGGCACGTGCCR	HES7	0.00652	2.64e-05	208	2.55	207	1.66	1.53	DOX_24_DD_down
178	36	MA0604.1	Atf1	MA0604.1	RTGACGTA	Atf1	0.00766	3.08e-05	2340	28.7	3230	26	1.11	DOX_24_DD_down
179	71	MA1521.1	MAFA	MA1521.1	NTGCTGASTCAGCAN	MAFA	0.00774	3.1e-05	407	4.99	465	3.74	1.33	DOX_24_DD_down
180	56	MA1535.1	NR2C1	MA1535.1	NRRGGTCAN	NR2C1	0.00888	3.53e-05	5520	67.6	8060	64.8	1.04	DOX_24_DD_down
181	37	MA0500.2	MYOG	MA0500.2	NDRCAGCTGYHN	MYOG	0.0154	6.09e-05	2310	28.3	3190	25.6	1.1	DOX_24_DD_down
182	72	MA1528.1	NFIX	MA1528.1	STTGGCRNNGTGCCARB	NFIX	0.0158	6.23e-05	2070	25.4	2850	22.9	1.11	DOX_24_DD_down
183	73	MA1651.1	ZFP42	MA1651.1	NNNHCAARATGGCTGCCNBNN	ZFP42	0.0202	7.89e-05	2520	30.9	3510	28.2	1.09	DOX_24_DD_down
184	40	MA0056.2	MZF1	MA0056.2	NNAATCCCCANNN	MZF1	0.0215	8.38e-05	5960	73	8750	70.4	1.04	DOX_24_DD_down
185	74	MA1936.1	ERF::FOXO1	MA1936.1	RTMAACAGGAARBS	ERF::FOXO1	0.0232	8.99e-05	5280	64.7	7710	62	1.04	DOX_24_DD_down
186	55	MA0861.1	TP73	MA0861.1	DRCATGTCNNRACAYGYM	TP73	0.0236	9.1e-05	1590	19.5	2150	17.3	1.13	DOX_24_DD_down
187	23	MA0603.1	Arntl	MA0603.1	NGTCACGTGH	Arntl	0.0327	0.000125	543	6.65	661	5.31	1.25	DOX_24_DD_down
188	49	MA0156.3	FEV	MA0156.3	VACCGGAAGTVV	FEV	0.0332	0.000127	521	6.38	631	5.07	1.26	DOX_24_DD_down
189	31	MA1715.1	ZNF707	MA1715.1	CCCCACTCCTGGTAC	ZNF707	0.0423	0.00016	982	12	1280	10.3	1.17	DOX_24_DD_down
9	75	MA1125.1 (ZNF384)	MEME-1	TTTTTTTTTTTTTTT	TTTTTTTTTTTTTTT	ZNF384	1.98	0.22	181	2.22	253	2.03	1.09	DOX_24_DD_down
10	76	MA1107.2 (KLF9)	MEME-2	TGTGTGTGTGTGTGT	TGTGTGTGTGTGTGT	KLF9	2.76	0.276	36	0.44	47	0.38	1.17	DOX_24_DD_down

ER_rat <- 1.25

DOX_24_DD_down_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DOX_24_DD_down_combo response peaks(200bp)Enrichment ratio:",ER_rat))

DOX_24_DD_down_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DOX_24_DD_down_combo response peaks(200bp)Enrichment ratio:",ER_rat))

EPI

EPI 24_up hour

EPI_24_DD_up_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_DEG_24_up_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
EPI_24_DD_up_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_DEG_24_up_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
EPI_24_DD_up_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_DEG_24_up_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
EPI_24_DD_up_sea_all <- rbind(EPI_24_DD_up_sea_disc, EPI_24_DD_up_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

EPI_24_DD_up_combo <- EPI_24_DD_up_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., EPI_24_DD_up_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="EPI_24_DD_up")

EPI_24_DD_up_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "EPI_24_DD_up EPI enriched motifs") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

EPI_24_DD_up EPI enriched motifs
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA0146.2 (Zfx)	STREME-1	1-AGCCTGGGCVRSRBR	AGCCTGGGCVRSRBR	Zfx	5.2e-12	4.24e-12	2050	25.7	4760	21.4	1.2	EPI_24_DD_up
2	2	MA1596.1 (ZNF460)	MEME-3	GGAGGYKGRGGNRGG	GGAGGYKGRGGNRGG	ZNF460	6.3e-11	2.57e-11	1860	23.3	4300	19.4	1.2	EPI_24_DD_up
3	3	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	3.56e-09	9.68e-10	2960	37	7280	32.8	1.13	EPI_24_DD_up
4	1	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	1.24e-07	2.52e-08	2130	26.6	5120	23.1	1.15	EPI_24_DD_up
5	1	MA1973.1 (ZKSCAN3)	MEME-2	CCAGCCTGGGCRACA	CCAGCCTGGGCRACA	ZKSCAN3	1.28e-06	2.08e-07	299	3.74	538	2.42	1.55	EPI_24_DD_up
6	4	MA1542.1	OSR1	MA1542.1	HGCTACYGTD	OSR1	4.62e-06	5.96e-07	5600	70	14800	66.6	1.05	EPI_24_DD_up
7	5	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	5.11e-06	5.96e-07	3480	43.5	8860	39.9	1.09	EPI_24_DD_up
8	6	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	6.06e-06	6.18e-07	6610	82.6	17700	79.7	1.04	EPI_24_DD_up
9	7	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	8.51e-06	7.72e-07	2090	26.2	5120	23	1.14	EPI_24_DD_up
10	2	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	1.27e-05	1.04e-06	813	10.2	1800	8.09	1.26	EPI_24_DD_up
11	8	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	2.46e-05	1.82e-06	3450	43.1	8810	39.6	1.09	EPI_24_DD_up
12	9	MA1648.1	TCF12	MA1648.1	NNCACCTGCNN	TCF12	6.8e-05	4.63e-06	5650	70.6	15000	67.4	1.05	EPI_24_DD_up
13	5	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	0.000114	7.14e-06	3710	46.4	9560	43	1.08	EPI_24_DD_up
14	5	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	0.000135	7.9e-06	6000	75	16000	72	1.04	EPI_24_DD_up
15	10	MA1979.1	ZNF416	MA1979.1	TATCTGGGCAH	ZNF416	0.000335	1.82e-05	2920	36.5	7420	33.4	1.09	EPI_24_DD_up
4	18	MA1125.1 (ZNF384)	MEME-4	TTTTTTTTTTTTTTG	TTTTTTTTTTTTTTG	ZNF384	0.000746	0.000186	251	3.14	521	2.35	1.34	EPI_24_DD_up
16	11	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	0.0015	7.63e-05	4170	52.1	10900	49.1	1.06	EPI_24_DD_up
17	5	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	0.002	9.59e-05	4530	56.7	11900	53.7	1.06	EPI_24_DD_up
18	20	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	0.00326	0.000148	230	2.88	441	1.99	1.45	EPI_24_DD_up
19	2	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	0.00389	0.000167	3400	42.4	8800	39.6	1.07	EPI_24_DD_up
5	19	2-CACTGCACCCA	STREME-2	2-CACTGCACCCA	CACTGCACCCA	CACTGCACCCA	0.00414	0.000828	7060	88.3	19300	86.9	1.02	EPI_24_DD_up
20	3	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	0.00498	0.000203	500	6.25	1100	4.94	1.27	EPI_24_DD_up
21	12	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	0.00668	0.00026	3270	40.9	8460	38.1	1.07	EPI_24_DD_up
22	2	MA1587.1	ZNF135	MA1587.1	CCTCGACCTCCYRR	ZNF135	0.00925	0.000343	635	7.94	1450	6.51	1.22	EPI_24_DD_up
23	13	MA0145.2	Tfcp2l1	MA0145.2	CCAGYYYVADCCRG	Tfcp2l1	0.0106	0.000375	6600	82.4	17800	80.3	1.03	EPI_24_DD_up
24	5	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	0.011	0.000375	5190	64.9	13800	62.2	1.04	EPI_24_DD_up
25	9	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	0.0127	0.000414	1090	13.7	2640	11.9	1.15	EPI_24_DD_up
26	14	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	0.0134	0.000422	5140	64.3	13700	61.7	1.04	EPI_24_DD_up
27	5	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	0.0159	0.00048	6780	84.7	18400	82.7	1.02	EPI_24_DD_up
28	14	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	0.0218	0.000636	3430	42.9	8950	40.3	1.06	EPI_24_DD_up
29	15	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	0.0278	0.000783	4850	60.6	12900	58	1.04	EPI_24_DD_up
30	16	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	0.0355	0.000964	2940	36.7	7610	34.3	1.07	EPI_24_DD_up
31	17	MA1147.1	NR4A2::RXRA	MA1147.1	VRGGTCRTTGACCYY	NR4A2::RXRA	0.0494	0.0013	3990	49.9	10500	47.4	1.05	EPI_24_DD_up
6	20	MA1615.1 (Plagl1)	STREME-4	4-GCCCCAGGNS	GCCCCAGGNS	Plagl1	0.142	0.0236	95	1.19	201	0.9	1.32	EPI_24_DD_up
7	21	MA0471.2 (E2F6)	STREME-3	3-CCCGCCTCCG	CCCGCCTCCG	E2F6	2.88	0.411	7	0.09	15	0.07	1.39	EPI_24_DD_up
8	22	MA1130.1 (FOSL2::JUN)	MEME-1	DDVTGAGTCAT	DDVTGAGTCAT	FOSL2::JUN	7.82	0.977	331	4.14	1040	4.67	0.888	EPI_24_DD_up

ER_rat <- 1.25

EPI_24_DD_up_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("EPI_24_DD_up_combo response peaks(200bp)Enrichment ratio:",ER_rat))

EPI_24_DD_up_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*.5), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.5,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("EPI_24_DD_up_combo response peaks(200bp)Enrichment ratio:",ER_rat))

EPI 24_down hour

EPI_24_DD_down_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_DEG_24_down_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
EPI_24_DD_down_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_DEG_24_down_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
EPI_24_DD_down_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EPI_DEG_24_down_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
EPI_24_DD_down_sea_all <- rbind(EPI_24_DD_down_sea_disc, EPI_24_DD_down_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

EPI_24_DD_down_combo <- EPI_24_DD_down_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., EPI_24_DD_down_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="EPI_24_DD_down")

EPI_24_DD_down_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "EPI_24_DD_down EPI enriched motifs") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

EPI_24_DD_down EPI enriched motifs
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA1712.1 (ZNF454)	STREME-2	2-CGCGCCSCNGSS	CGCGCCSCNGSS	ZNF454	3.03e-62	2.16e-62	1160	15.1	953	7.47	2.02	EPI_24_DD_down
2	2	MA1721.1 (ZNF93)	STREME-1	1-CCGCCSCCSCCSCSS	CCGCCSCCSCCSCSS	ZNF93	1.38e-56	4.9e-57	1320	17.1	1190	9.31	1.84	EPI_24_DD_down
3	3	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	1.57e-53	3.72e-54	1230	16	1100	8.65	1.85	EPI_24_DD_down
4	4	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	9.09e-52	1.62e-52	1360	17.6	1280	10	1.76	EPI_24_DD_down
5	5	5-CCGNCGG	STREME-5	5-CCGNCGG	CCGNCGG	CCGNCGG	3.67e-50	5.22e-51	1390	18.1	1340	10.5	1.73	EPI_24_DD_down
6	6	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	7.51e-46	8.9e-47	1320	17.2	1280	10	1.71	EPI_24_DD_down
7	7	3-CCGCCTCC	STREME-3	3-CCGCCTCC	CCGCCTCC	CCGCCTCC	8.95e-43	9.09e-44	1500	19.5	1550	12.1	1.61	EPI_24_DD_down
8	8	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	9.18e-41	8.15e-42	2210	28.7	2580	20.2	1.42	EPI_24_DD_down
9	9	MA0146.2 (Zfx)	STREME-4	4-GCCSSGGC	GCCSSGGC	Zfx	3.08e-40	2.43e-41	946	12.3	841	6.59	1.86	EPI_24_DD_down
10	6	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	6.09e-39	4.33e-40	1630	21.2	1760	13.8	1.53	EPI_24_DD_down
11	10	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	6.28e-37	4.06e-38	764	9.92	641	5.02	1.97	EPI_24_DD_down
12	11	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	7.42e-37	4.4e-38	732	9.5	603	4.72	2.01	EPI_24_DD_down
13	4	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	1.75e-34	9.59e-36	3160	41	4110	32.2	1.27	EPI_24_DD_down
14	12	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	3.57e-34	1.81e-35	2430	31.6	2990	23.4	1.35	EPI_24_DD_down
15	13	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	5.28e-33	2.5e-34	1820	23.7	2110	16.5	1.43	EPI_24_DD_down
16	4	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	7.64e-33	3.39e-34	2480	32.2	3080	24.2	1.33	EPI_24_DD_down
17	8	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	6.5e-32	2.72e-33	1470	19.1	1620	12.7	1.51	EPI_24_DD_down
18	14	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	1.26e-30	4.98e-32	3000	39	3920	30.7	1.27	EPI_24_DD_down
19	15	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	3.94e-30	1.48e-31	1750	22.7	2030	15.9	1.42	EPI_24_DD_down
20	6	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	5.61e-30	1.95e-31	2210	28.7	2720	21.3	1.35	EPI_24_DD_down
21	8	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	5.77e-30	1.95e-31	3150	40.9	4160	32.6	1.25	EPI_24_DD_down
22	8	MA0732.1	EGR3	MA0732.1	HHMCGCCCACGCAHH	EGR3	8.51e-30	2.75e-31	1690	21.9	1950	15.3	1.43	EPI_24_DD_down
23	13	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	9.97e-30	3.08e-31	2690	34.9	3450	27	1.29	EPI_24_DD_down
24	16	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	1.96e-29	5.82e-31	1750	22.7	2040	16	1.42	EPI_24_DD_down
25	13	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	4.36e-29	1.24e-30	975	12.7	972	7.62	1.66	EPI_24_DD_down
26	17	MA0024.3	E2F1	MA0024.3	TTTGGCGCCAAA	E2F1	3.45e-28	9.44e-30	1290	16.7	1400	11	1.52	EPI_24_DD_down
27	6	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	9.53e-28	2.51e-29	3560	46.2	4850	38	1.21	EPI_24_DD_down
28	18	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	1.43e-27	3.63e-29	3070	39.8	4080	31.9	1.25	EPI_24_DD_down
29	6	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	1.83e-27	4.49e-29	2610	33.9	3370	26.4	1.29	EPI_24_DD_down
30	17	MA0864.2	E2F2	MA0864.2	RWTTTGGCGCCAWWWY	E2F2	3.03e-27	7.17e-29	1040	13.5	1070	8.41	1.6	EPI_24_DD_down
31	6	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	9.54e-27	2.19e-28	4010	52.1	5610	44	1.18	EPI_24_DD_down
32	6	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	1.05e-26	2.34e-28	3370	43.7	4570	35.8	1.22	EPI_24_DD_down
33	19	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	1.17e-26	2.52e-28	3270	42.4	4410	34.6	1.23	EPI_24_DD_down
34	17	MA0470.2	E2F4	MA0470.2	TTTTGGCGCCAWWW	E2F4	1.32e-26	2.77e-28	1090	14.2	1150	9.02	1.57	EPI_24_DD_down
35	20	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	5.93e-26	1.2e-27	3410	44.2	4640	36.4	1.22	EPI_24_DD_down
36	6	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	6.35e-26	1.25e-27	3500	45.5	4800	37.6	1.21	EPI_24_DD_down
37	6	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	7.66e-26	1.47e-27	1100	14.2	1170	9.14	1.56	EPI_24_DD_down
38	8	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	1.09e-25	2.03e-27	2170	28.2	2720	21.3	1.32	EPI_24_DD_down
39	6	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	1.4e-25	2.56e-27	4080	52.9	5740	45	1.18	EPI_24_DD_down
40	6	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	2.97e-24	5.28e-26	3840	49.8	5380	42.1	1.18	EPI_24_DD_down
41	21	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	3.33e-24	5.77e-26	2270	29.4	2890	22.7	1.3	EPI_24_DD_down
42	22	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	8.72e-24	1.48e-25	705	9.15	669	5.24	1.75	EPI_24_DD_down
43	23	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	1.26e-23	2.08e-25	1030	13.3	1100	8.59	1.55	EPI_24_DD_down
44	6	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	5.5e-23	8.88e-25	1100	14.2	1200	9.39	1.51	EPI_24_DD_down
45	6	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	9.78e-23	1.54e-24	3120	40.5	4250	33.3	1.22	EPI_24_DD_down
46	6	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	1.26e-22	1.95e-24	3420	44.4	4720	37	1.2	EPI_24_DD_down
47	24	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	1.29e-22	1.95e-24	3400	44.1	4690	36.8	1.2	EPI_24_DD_down
48	25	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	1.35e-22	2e-24	3440	44.6	4760	37.3	1.2	EPI_24_DD_down
49	23	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	1.43e-22	2.07e-24	1940	25.2	2420	19	1.33	EPI_24_DD_down
50	18	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	7.29e-22	1.04e-23	428	5.56	343	2.69	2.07	EPI_24_DD_down
51	26	MA1985.1	ZNF669	MA1985.1	GGGGYGAYGACCRCT	ZNF669	1.46e-21	2.03e-23	2540	32.9	3350	26.2	1.25	EPI_24_DD_down
52	23	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	1.88e-21	2.57e-23	1890	24.6	2370	18.6	1.32	EPI_24_DD_down
53	6	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	3.48e-21	4.67e-23	3880	50.4	5510	43.2	1.17	EPI_24_DD_down
54	20	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	4.92e-21	6.48e-23	3690	47.9	5200	40.8	1.18	EPI_24_DD_down
55	27	MA0736.1	GLIS2	MA0736.1	GACCCCCCGCRAMG	GLIS2	5.76e-21	7.45e-23	2160	28	2780	21.8	1.29	EPI_24_DD_down
56	6	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	7.04e-21	8.94e-23	4210	54.6	6050	47.4	1.15	EPI_24_DD_down
57	72	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	1.34e-20	1.67e-22	1140	14.8	1290	10.1	1.46	EPI_24_DD_down
58	28	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	1.37e-20	1.68e-22	2620	34	3500	27.4	1.24	EPI_24_DD_down
59	6	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	3.31e-20	3.99e-22	4420	57.4	6430	50.4	1.14	EPI_24_DD_down
60	6	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	3.41e-20	4.04e-22	537	6.97	487	3.82	1.83	EPI_24_DD_down
61	6	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	5.83e-20	6.7e-22	4630	60	6770	53	1.13	EPI_24_DD_down
62	29	MA1966.1	TFAP4::ETV1	MA1966.1	RSCGGAAGCAGSTGKN	TFAP4::ETV1	5.84e-20	6.7e-22	1990	25.8	2540	19.9	1.3	EPI_24_DD_down
63	30	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	6.1e-20	6.89e-22	2600	33.8	3490	27.3	1.24	EPI_24_DD_down
64	31	MA1650.1 (ZBTB14)	STREME-7	7-CGCACGCN	CGCACGCN	ZBTB14	9.46e-20	1.05e-21	323	4.19	236	1.85	2.26	EPI_24_DD_down
65	17	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	1.74e-19	1.91e-21	1130	14.7	1290	10.1	1.45	EPI_24_DD_down
66	22	MA1569.1	TFAP2E	MA1569.1	YGCCYSRGGCD	TFAP2E	2.53e-19	2.72e-21	487	6.32	432	3.38	1.87	EPI_24_DD_down
67	18	MA0649.1	HEY2	MA0649.1	GRCACGTGYC	HEY2	2.75e-19	2.92e-21	3780	49.1	5380	42.2	1.16	EPI_24_DD_down
68	6	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	6.41e-19	6.7e-21	4500	58.4	6580	51.6	1.13	EPI_24_DD_down
69	27	MA0751.1	ZIC4	MA0751.1	GRCCCCCCGCKGYGH	ZIC4	6.61e-19	6.81e-21	2950	38.3	4050	31.7	1.21	EPI_24_DD_down
70	32	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	8.04e-19	8.16e-21	1650	21.4	2050	16	1.33	EPI_24_DD_down
71	6	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	1.57e-18	1.58e-20	1060	13.8	1200	9.44	1.46	EPI_24_DD_down
72	33	MA1987.1	ZNF701	MA1987.1	GAGCACYAARGGGGGRADDDD	ZNF701	2.95e-18	2.91e-20	3830	49.8	5490	43	1.16	EPI_24_DD_down
73	29	MA1941.1	ETV2::FIGLA	MA1941.1	RSCGGAARCAGSTGBN	ETV2::FIGLA	7.97e-18	7.76e-20	3480	45.2	4920	38.6	1.17	EPI_24_DD_down
74	34	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	8.14e-18	7.82e-20	1920	24.9	2480	19.4	1.29	EPI_24_DD_down
75	18	MA1099.2	HES1	MA1099.2	GGCRCGTGBC	HES1	1.17e-17	1.11e-19	267	3.47	186	1.46	2.37	EPI_24_DD_down
76	35	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	4.16e-17	3.89e-19	2790	36.2	3830	30	1.21	EPI_24_DD_down
77	29	MA0750.2	ZBTB7A	MA0750.2	NVCCGGAAGTGSV	ZBTB7A	7.72e-17	7.13e-19	1430	18.6	1760	13.8	1.35	EPI_24_DD_down
78	33	MA0528.2	ZNF263	MA0528.2	VNGGGGAGGASG	ZNF263	1.04e-16	9.44e-19	3110	40.4	4350	34.1	1.18	EPI_24_DD_down
79	18	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	3.01e-16	2.71e-18	3780	49.1	5460	42.8	1.15	EPI_24_DD_down
80	36	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	3.3e-16	2.94e-18	2030	26.4	2670	20.9	1.26	EPI_24_DD_down
81	6	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	7.02e-16	6.16e-18	4710	61.2	7010	54.9	1.11	EPI_24_DD_down
82	37	MA0597.2	THAP1	MA0597.2	VSGCAGGGCASV	THAP1	7.21e-16	6.25e-18	3060	39.8	4300	33.7	1.18	EPI_24_DD_down
83	22	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	7.46e-16	6.39e-18	2700	35	3710	29.1	1.2	EPI_24_DD_down
84	27	MA1584.1	ZIC5	MA1584.1	VGACCCCCCGCTGHGM	ZIC5	9.89e-16	8.37e-18	995	12.9	1150	9	1.43	EPI_24_DD_down
85	6	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	3.26e-15	2.73e-17	4420	57.4	6540	51.2	1.12	EPI_24_DD_down
86	18	MA0616.2	HES2	MA0616.2	GGCACGTGYC	HES2	3.69e-15	3.05e-17	556	7.22	556	4.36	1.66	EPI_24_DD_down
87	18	MA1648.1	TCF12	MA1648.1	NNCACCTGCNN	TCF12	4.23e-15	3.45e-17	1480	19.2	1860	14.6	1.32	EPI_24_DD_down
88	38	MA0615.1	Gmeb1	MA0615.1	BHBBKKACGTMMNWNNN	Gmeb1	7.5e-15	6.06e-17	651	8.45	685	5.37	1.57	EPI_24_DD_down
89	27	MA0696.1	ZIC1	MA0696.1	GACCCCCYGCTGTG	ZIC1	5.66e-14	4.52e-16	2020	26.3	2700	21.2	1.24	EPI_24_DD_down
90	6	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	9.89e-14	7.81e-16	4440	57.6	6600	51.7	1.11	EPI_24_DD_down
91	39	MA0597.2 (THAP1)	STREME-6	6-MSGGMAGGGC	MSGGMAGGGC	THAP1	1.07e-13	8.32e-16	3480	45.2	5020	39.4	1.15	EPI_24_DD_down
92	40	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	1.9e-13	1.47e-15	5110	66.4	7750	60.7	1.09	EPI_24_DD_down
93	18	MA0259.1	ARNT::HIF1A	MA0259.1	VBACGTGC	ARNT::HIF1A	2.64e-13	2.02e-15	2930	38	4140	32.4	1.17	EPI_24_DD_down
94	23	MA0815.1	TFAP2C	MA0815.1	TGCCCYSRGGGCA	TFAP2C	5.15e-13	3.89e-15	1870	24.3	2490	19.5	1.24	EPI_24_DD_down
95	23	MA0872.1	TFAP2A	MA0872.1	TGCCCYSRGGGCA	TFAP2A	7.36e-13	5.51e-15	1920	25	2580	20.2	1.24	EPI_24_DD_down
96	41	MA1628.1	Zic1::Zic2	MA1628.1	CVCAGCAGGNV	Zic1::Zic2	7.65e-13	5.67e-15	3520	45.7	5110	40.1	1.14	EPI_24_DD_down
97	40	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	9.66e-13	7.08e-15	2340	30.4	3220	25.2	1.2	EPI_24_DD_down
98	19	MA1930.1	CTCF	MA1930.1	CTGCAGTKCCNVCHNNYRGCCASYAGRKGGCRAKC	CTCF	1.17e-12	8.5e-15	2290	29.8	3150	24.7	1.21	EPI_24_DD_down
99	27	MA1578.1	VEZF1	MA1578.1	CCCCCCMYDH	VEZF1	3.12e-12	2.22e-14	1690	22	2240	17.5	1.25	EPI_24_DD_down
100	36	MA1933.1	ELK1::SREBF2	MA1933.1	DCCGGAAGTSRCGTGA	ELK1::SREBF2	3.12e-12	2.22e-14	2300	29.8	3170	24.8	1.2	EPI_24_DD_down
101	40	MA0695.1	ZBTB7C	MA0695.1	RCGACCACCGAN	ZBTB7C	7.24e-12	5.1e-14	1670	21.7	2210	17.3	1.25	EPI_24_DD_down
102	22	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	9.14e-12	6.37e-14	1890	24.5	2540	19.9	1.23	EPI_24_DD_down
103	32	MA0067.2	PAX2	MA0067.2	BCAVTSRAGCGTGACGR	PAX2	1.61e-11	1.11e-13	1860	24.2	2510	19.7	1.23	EPI_24_DD_down
104	42	MA1973.1	ZKSCAN3	MA1973.1	KDKCCCAGGCTAGCCCABNN	ZKSCAN3	2.23e-11	1.53e-13	2860	37.1	4080	32	1.16	EPI_24_DD_down
105	23	MA0813.1	TFAP2B	MA0813.1	TGCCCYBRGGGCA	TFAP2B	2.83e-11	1.91e-13	1750	22.8	2350	18.4	1.24	EPI_24_DD_down
106	18	MA0147.3	MYC	MA0147.3	NNCCACGTGCNB	MYC	1.18e-10	7.93e-13	3380	43.8	4930	38.6	1.13	EPI_24_DD_down
107	43	MA1149.1	RARA::RXRG	MA1149.1	RRGGTCAHNNNRRGGTCA	RARA::RXRG	1.66e-10	1.1e-12	4840	62.8	7360	57.7	1.09	EPI_24_DD_down
108	44	MA1475.1	CREB3L4	MA1475.1	GRTGACGTCAYC	CREB3L4	2.27e-10	1.49e-12	2500	32.4	3530	27.6	1.17	EPI_24_DD_down
109	8	MA1656.1	ZNF449	MA1656.1	NNAAGCCCAACCNN	ZNF449	2.74e-10	1.79e-12	2770	35.9	3960	31	1.16	EPI_24_DD_down
110	45	MA1971.1	ZBED2	MA1971.1	NNMMCGAAACCNNV	ZBED2	2.85e-10	1.84e-12	4650	60.4	7050	55.2	1.09	EPI_24_DD_down
111	19	MA1929.1	CTCF	MA1929.1	CTGCAGTKCCNNNNNYNRCCASYAGRKGGCRSWG	CTCF	7.3e-10	4.67e-12	2410	31.3	3400	26.6	1.17	EPI_24_DD_down
112	18	MA1945.1	ETV5::FIGLA	MA1945.1	RGCGGAARCAGGTGG	ETV5::FIGLA	1.06e-09	6.7e-12	3180	41.3	4650	36.4	1.14	EPI_24_DD_down
113	18	MA1464.1	ARNT2	MA1464.1	GTCACGTGMN	ARNT2	2.56e-09	1.61e-11	1880	24.4	2580	20.2	1.2	EPI_24_DD_down
114	46	MA1684.1	Foxn1	MA1684.1	RGAMGC	Foxn1	3.31e-09	2.06e-11	1280	16.7	1680	13.2	1.27	EPI_24_DD_down
115	36	MA0765.3	ETV5	MA0765.3	ACCGGAAGTR	ETV5	3.69e-09	2.28e-11	1950	25.3	2690	21.1	1.2	EPI_24_DD_down
116	47	MA1545.1	OVOL2	MA1545.1	DDACCGTTABNYN	OVOL2	3.84e-09	2.35e-11	1320	17.2	1740	13.6	1.26	EPI_24_DD_down
117	20	MA0163.1	PLAG1	MA0163.1	GGGGCCCWAGGGGG	PLAG1	6.56e-09	3.99e-11	1030	13.4	1310	10.2	1.31	EPI_24_DD_down
118	18	MA0522.3	TCF3	MA0522.3	NVCACCTGCNN	TCF3	8.46e-09	5.1e-11	1120	14.5	1440	11.2	1.29	EPI_24_DD_down
119	18	MA0006.1	Ahr::Arnt	MA0006.1	YGCGTG	Ahr::Arnt	1.04e-08	6.2e-11	2180	28.3	3070	24.1	1.18	EPI_24_DD_down
120	48	MA1710.1	ZNF257	MA1710.1	VDGAGGCRAGRG	ZNF257	1.17e-08	6.91e-11	2830	36.7	4100	32.2	1.14	EPI_24_DD_down
121	19	MA0155.1	INSM1	MA0155.1	TGYCWGGGGGCR	INSM1	1.4e-08	8.21e-11	2160	28	3040	23.9	1.18	EPI_24_DD_down
122	18	MA0464.2	BHLHE40	MA0464.2	VKCACGTGMC	BHLHE40	2.59e-08	1.51e-10	1270	16.4	1670	13.1	1.26	EPI_24_DD_down
123	49	MA1521.1	MAFA	MA1521.1	NTGCTGASTCAGCAN	MAFA	2.61e-08	1.51e-10	1420	18.5	1910	15	1.23	EPI_24_DD_down
124	50	MA1719.1	ZNF816	MA1719.1	DRRKGGGGACATGCHGGG	ZNF816	3.09e-08	1.77e-10	5130	66.5	7920	62	1.07	EPI_24_DD_down
125	18	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	3.79e-08	2.15e-10	284	3.69	272	2.13	1.73	EPI_24_DD_down
126	18	MA1560.1	SOHLH2	MA1560.1	YGCACGTGCN	SOHLH2	4.4e-08	2.48e-10	1190	15.4	1560	12.2	1.26	EPI_24_DD_down
127	18	MA1106.1	HIF1A	MA1106.1	SBACGTGCNN	HIF1A	5.31e-08	2.97e-10	914	11.9	1150	9.03	1.31	EPI_24_DD_down
128	51	MA1964.1	SMAD2	MA1964.1	NBCCAGACDN	SMAD2	6.32e-08	3.51e-10	4010	52.1	6060	47.4	1.1	EPI_24_DD_down
129	18	MA1631.1	ASCL1	MA1631.1	NNGCACCTGCYNB	ASCL1	8.97e-08	4.94e-10	1520	19.7	2060	16.2	1.22	EPI_24_DD_down
130	52	MA1982.1	ZNF574	MA1982.1	VGSCTAGAGMGGCCS	ZNF574	9.63e-08	5.26e-10	3420	44.4	5090	39.9	1.11	EPI_24_DD_down
131	53	MA1728.1	ZNF549	MA1728.1	NNTGCTGCCCWR	ZNF549	1.35e-07	7.35e-10	5550	72	8660	67.8	1.06	EPI_24_DD_down
132	54	MA1557.1	SMAD5	MA1557.1	YGTCTAGACA	SMAD5	1.76e-07	9.49e-10	3350	43.5	4980	39	1.11	EPI_24_DD_down
133	41	MA0697.2	Zic3	MA0697.2	CNCAGCAGGAGNN	Zic3	1.9e-07	1.02e-09	2300	29.8	3290	25.8	1.16	EPI_24_DD_down
134	40	MA0694.1	ZBTB7B	MA0694.1	RCGACCACCGAA	ZBTB7B	2.16e-07	1.14e-09	1150	15	1520	11.9	1.26	EPI_24_DD_down
135	18	MA0603.1	Arntl	MA0603.1	NGTCACGTGH	Arntl	5.68e-07	2.99e-09	4550	59.1	6980	54.7	1.08	EPI_24_DD_down
136	41	MA1629.1	Zic2	MA1629.1	NDCACAGCAGGDRG	Zic2	6.05e-07	3.16e-09	3950	51.2	5980	46.9	1.09	EPI_24_DD_down
137	19	MA0139.1	CTCF	MA0139.1	YGRCCASYAGRKGGCRSYR	CTCF	8.2e-07	4.25e-09	4380	56.8	6700	52.5	1.08	EPI_24_DD_down
138	18	MA1493.1	HES6	MA1493.1	GGCACGTGTY	HES6	1.06e-06	5.44e-09	2120	27.5	3040	23.8	1.16	EPI_24_DD_down
139	55	MA0767.1	GCM2	MA0767.1	BATGCGGGTR	GCM2	1.19e-06	6.08e-09	4770	61.9	7360	57.6	1.07	EPI_24_DD_down
140	29	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	1.23e-06	6.25e-09	3320	43.1	4960	38.9	1.11	EPI_24_DD_down
141	29	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	1.34e-06	6.74e-09	2870	37.3	4240	33.2	1.12	EPI_24_DD_down
142	56	MA1972.1	ZFP14	MA1972.1	GGAGGCHCHGGARBG	ZFP14	1.91e-06	9.57e-09	4110	53.3	6260	49.1	1.09	EPI_24_DD_down
143	18	MA0104.4	MYCN	MA0104.4	VVCCACGTGGBB	MYCN	2.34e-06	1.16e-08	4470	58.1	6880	53.9	1.08	EPI_24_DD_down
144	57	MA1655.1	ZNF341	MA1655.1	NRGAACAGCCNN	ZNF341	3.09e-06	1.52e-08	3380	43.9	5070	39.7	1.1	EPI_24_DD_down
145	18	MA1934.1	ERF::FIGLA	MA1934.1	RCCGGAARCASCTGBN	ERF::FIGLA	4.3e-06	2.1e-08	1150	14.9	1540	12.1	1.23	EPI_24_DD_down
146	29	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	4.31e-06	2.1e-08	2890	37.5	4280	33.5	1.12	EPI_24_DD_down
147	22	MA1581.1	ZBTB6	MA1581.1	DNSCTTGAGCCNV	ZBTB6	7.24e-06	3.5e-08	4790	62.1	7420	58.1	1.07	EPI_24_DD_down
148	17	MA1727.1	ZNF417	MA1727.1	VRBVNTGGGCGCCAM	ZNF417	8.55e-06	4.1e-08	295	3.83	310	2.43	1.58	EPI_24_DD_down
149	32	MA1995.1	Npas4	MA1995.1	NNTCGTGACHN	Npas4	1.41e-05	6.74e-08	3790	49.2	5770	45.2	1.09	EPI_24_DD_down
150	55	MA0646.1	GCM1	MA0646.1	BATGCGGGTAC	GCM1	3.03e-05	1.43e-07	4150	53.9	6380	50	1.08	EPI_24_DD_down
151	29	MA0764.3	ETV4	MA0764.3	ACCGGAAGTR	ETV4	3.33e-05	1.57e-07	579	7.52	715	5.6	1.34	EPI_24_DD_down
152	18	MA0608.1	Creb3l2	MA0608.1	GCCACGTGD	Creb3l2	3.81e-05	1.78e-07	1190	15.4	1630	12.8	1.21	EPI_24_DD_down
153	58	MA1716.1	ZNF76	MA1716.1	NNTWCCCAYAATGCAHYGCGC	ZNF76	6.09e-05	2.83e-07	1240	16.1	1710	13.4	1.2	EPI_24_DD_down
154	29	MA1529.1	NHLH2	MA1529.1	GGGNCGCAGCTGCGYCCC	NHLH2	6.19e-05	2.86e-07	1520	19.7	2140	16.8	1.17	EPI_24_DD_down
155	59	MA1652.1	ZKSCAN5	MA1652.1	NNRGGARGTGAGRR	ZKSCAN5	7.06e-05	3.24e-07	4900	63.6	7650	59.9	1.06	EPI_24_DD_down
156	18	MA1474.1	CREB3L4	MA1474.1	YGCCACGTCAYC	CREB3L4	7.47e-05	3.41e-07	710	9.22	913	7.15	1.29	EPI_24_DD_down
157	60	MA0145.2	Tfcp2l1	MA0145.2	CCAGYYYVADCCRG	Tfcp2l1	0.000179	8.12e-07	5950	77.2	9450	74	1.04	EPI_24_DD_down
158	36	MA0156.3	FEV	MA0156.3	VACCGGAAGTVV	FEV	0.000211	9.48e-07	2140	27.8	3140	24.6	1.13	EPI_24_DD_down
159	61	MA1146.1	NR1H4::RXRA	MA1146.1	GAGKTCATTGACCYB	NR1H4::RXRA	0.000257	1.15e-06	5500	71.4	8680	68	1.05	EPI_24_DD_down
160	62	MA1711.1	ZNF343	MA1711.1	CCGCTTCMCCDCGGCMV	ZNF343	0.000272	1.21e-06	756	9.81	993	7.78	1.26	EPI_24_DD_down
161	63	MA0511.2	RUNX2	MA0511.2	WAACCGCAA	RUNX2	0.000302	1.33e-06	4130	53.6	6390	50.1	1.07	EPI_24_DD_down
162	43	MA0159.1	RARA::RXRA	MA0159.1	RGKTCANVGRSAGGTCA	RARA::RXRA	0.00034	1.49e-06	3490	45.2	5320	41.7	1.08	EPI_24_DD_down
163	61	MA1147.1	NR4A2::RXRA	MA1147.1	VRGGTCRTTGACCYY	NR4A2::RXRA	0.000356	1.55e-06	5330	69.2	8400	65.8	1.05	EPI_24_DD_down
164	18	MA0636.1	BHLHE41	MA0636.1	RTCACGTGAC	BHLHE41	0.000474	2.05e-06	308	4	349	2.73	1.46	EPI_24_DD_down
165	44	MA0604.1	Atf1	MA0604.1	RTGACGTA	Atf1	0.00052	2.24e-06	1090	14.1	1500	11.8	1.2	EPI_24_DD_down
166	18	MA0004.1	Arnt	MA0004.1	CACGTG	Arnt	0.000523	2.24e-06	1600	20.8	2300	18	1.15	EPI_24_DD_down
167	50	MA0056.2	MZF1	MA0056.2	NNAATCCCCANNN	MZF1	0.000617	2.63e-06	5650	73.3	8960	70.2	1.04	EPI_24_DD_down
168	18	MA0822.1	HES7	MA0822.1	YGGCACGTGCCR	HES7	0.000654	2.77e-06	303	3.93	344	2.7	1.46	EPI_24_DD_down
169	36	MA0028.2	ELK1	MA0028.2	ACCGGAAGTR	ELK1	0.00073	3.07e-06	690	8.96	904	7.08	1.26	EPI_24_DD_down
170	29	MA1635.1	BHLHE22	MA1635.1	NVCAGCTGBN	BHLHE22	0.000929	3.88e-06	2430	31.6	3630	28.4	1.11	EPI_24_DD_down
171	64	MA1979.1	ZNF416	MA1979.1	TATCTGGGCAH	ZNF416	0.00153	6.36e-06	5660	73.4	8990	70.4	1.04	EPI_24_DD_down
172	29	MA1485.1	FERD3L	MA1485.1	GCRMCAGCTGTYAC	FERD3L	0.00169	7e-06	1680	21.8	2430	19.1	1.14	EPI_24_DD_down
173	57	MA1730.1	ZNF708	MA1730.1	NNRGCTGTRCCTCCY	ZNF708	0.00263	1.08e-05	5240	68	8290	64.9	1.05	EPI_24_DD_down
174	65	MA1715.1	ZNF707	MA1715.1	CCCCACTCCTGGTAC	ZNF707	0.00607	2.48e-05	1010	13.1	1410	11	1.19	EPI_24_DD_down
175	66	MA0154.4	EBF1	MA0154.4	NNTCCCCAGGGGANN	EBF1	0.0115	4.68e-05	2040	26.5	3050	23.9	1.11	EPI_24_DD_down
176	67	MA2002.1	Zfp335	MA2002.1	VNTCAGGCANH	Zfp335	0.0128	5.18e-05	6530	84.8	10500	82.5	1.03	EPI_24_DD_down
177	18	MA0058.3	MAX	MA0058.3	AVCACGTGNY	MAX	0.0134	5.39e-05	3660	47.5	5680	44.5	1.07	EPI_24_DD_down
178	68	MA1554.1	RFX7	MA1554.1	CGTTGCYAY	RFX7	0.0148	5.92e-05	410	5.32	518	4.06	1.31	EPI_24_DD_down
179	69	MA1643.1	NFIB	MA1643.1	NNCCTGGCAYNGTGCCAAGNN	NFIB	0.016	6.36e-05	2520	32.7	3820	29.9	1.09	EPI_24_DD_down
180	44	MA1575.1	THRB	MA1575.1	DTGACCTBRNYVAGGTCAH	THRB	0.0169	6.67e-05	1220	15.8	1750	13.7	1.15	EPI_24_DD_down
181	70	MA1616.1	Prdm15	MA1616.1	NRGAAAACCTGGAVN	Prdm15	0.0172	6.76e-05	4720	61.2	7440	58.3	1.05	EPI_24_DD_down
182	61	MA0504.1	NR2C2	MA0504.1	VGRGGTCARAGGTCA	NR2C2	0.0188	7.34e-05	1380	17.9	2000	15.7	1.14	EPI_24_DD_down
183	18	MA0663.1	MLX	MA0663.1	RTCACGTGAT	MLX	0.0206	8.01e-05	1090	14.1	1550	12.2	1.16	EPI_24_DD_down
184	66	MA1637.1	EBF3	MA1637.1	NYCCCAAGGGANN	EBF3	0.0285	0.00011	1470	19.1	2150	16.9	1.13	EPI_24_DD_down
185	61	MA1553.1	RARG	MA1553.1	RAGGTCATGACCTY	RARG	0.0362	0.000139	2910	37.8	4480	35.1	1.08	EPI_24_DD_down
8	71	MA1125.1 (ZNF384)	MEME-1	AAAAAAAAAAAAAAA	AAAAAAAAAAAAAAA	ZNF384	4.38	0.536	212	2.75	349	2.73	1.01	EPI_24_DD_down
9	72	MA1107.2 (KLF9)	MEME-2	TGTGTGTGTGTGTGT	TGTGTGTGTGTGTGT	KLF9	4.82	0.536	229	2.97	381	2.98	0.997	EPI_24_DD_down

ER_rat <- 1.25

EPI_24_DD_down_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("EPI_24_DD_down_combo response peaks(200bp)Enrichment ratio:",ER_rat))

EPI_24_DD_down_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*2), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./2,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("EPI_24_DD_down_combo response peaks(200bp)Enrichment ratio:",ER_rat))

DNR

DNR 24_up hour

DNR_24_DD_up_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_DEG_24_up_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DNR_24_DD_up_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_DEG_24_up_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DNR_24_DD_up_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_DEG_24_up_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DNR_24_DD_up_sea_all <- rbind(DNR_24_DD_up_sea_disc, DNR_24_DD_up_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DNR_24_DD_up_combo <- DNR_24_DD_up_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DNR_24_DD_up_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="DNR_24_DD_up")

DNR_24_DD_up_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "DNR_24_DD_up DNR enriched motifs") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

DNR_24_DD_up DNR enriched motifs
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	6-RCCSGGY	STREME-6	6-RCCSGGY	RCCSGGY	RCCSGGY	4.48e-19	3.37e-19	6010	54.6	12500	49.1	1.11	DNR_24_DD_up
2	2	MA0146.2 (Zfx)	STREME-1	1-GCCTGGGCMRSVKGG	GCCTGGGCMRSVKGG	Zfx	2.41e-18	9.06e-19	4520	41.1	9150	35.9	1.15	DNR_24_DD_up
3	5	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	1.59e-11	3.99e-12	2940	26.6	5850	22.9	1.16	DNR_24_DD_up
4	3	CCAGGCTGGWSTGCA	MEME-4	CCAGGCTGGWSTGCA	CCAGGCTGGWSTGCA	CCAGGCTGGWSTGCA	3.3e-11	6.21e-12	456	4.14	669	2.62	1.58	DNR_24_DD_up
5	4	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	5.52e-11	8.32e-12	1760	16	3330	13	1.23	DNR_24_DD_up
6	5	MA1596.1 (ZNF460)	MEME-3	GGAGGCDGRGGYGGG	GGAGGCDGRGGYGGG	ZNF460	8.91e-11	1.12e-11	2430	22	4760	18.7	1.18	DNR_24_DD_up
7	4	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	1.95e-09	2.1e-10	5330	48.4	11300	44.5	1.09	DNR_24_DD_up
8	6	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	5.54e-09	5.22e-10	3120	28.3	6360	24.9	1.14	DNR_24_DD_up
9	7	5-CCCCAGC	STREME-5	5-CCCCAGC	CCCCAGC	CCCCAGC	1.17e-08	9.75e-10	3090	28	6290	24.7	1.14	DNR_24_DD_up
10	2	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	1.38e-08	1.04e-09	1590	14.4	3030	11.9	1.21	DNR_24_DD_up
11	8	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	1.78e-08	1.22e-09	5850	53.1	12600	49.4	1.08	DNR_24_DD_up
12	4	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	2.7e-08	1.7e-09	4910	44.6	10400	40.9	1.09	DNR_24_DD_up
13	4	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	3.47e-08	2.01e-09	3840	34.8	7990	31.3	1.11	DNR_24_DD_up
14	9	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	3.96e-08	2.13e-09	8190	74.4	18100	71.1	1.05	DNR_24_DD_up
15	6	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	5.02e-08	2.52e-09	5000	45.4	10700	41.8	1.09	DNR_24_DD_up
16	10	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	8.5e-08	4e-09	3080	27.9	6310	24.7	1.13	DNR_24_DD_up
17	4	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	1.62e-07	7.19e-09	2560	23.2	5170	20.3	1.15	DNR_24_DD_up
18	4	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	2.01e-07	8.4e-09	1280	11.6	2400	9.42	1.23	DNR_24_DD_up
19	6	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	2.29e-07	9.08e-09	5140	46.6	11000	43.1	1.08	DNR_24_DD_up
20	11	3-TGTCTCTAMAAAAA	STREME-3	3-TGTCTCTAMAAAAA	TGTCTCTAMAAAAA	TGTCTCTAMAAAAA	3.78e-07	1.42e-08	313	2.84	460	1.8	1.58	DNR_24_DD_up
21	12	MA0506.2 (Nrf1)	STREME-4	4-AGCGCAGG	AGCGCAGG	Nrf1	9.73e-07	3.49e-08	5710	51.8	12400	48.4	1.07	DNR_24_DD_up
22	13	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	1.15e-06	3.92e-08	2760	25.1	5670	22.2	1.13	DNR_24_DD_up
23	4	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	2.31e-06	7.26e-08	4300	39.1	9140	35.8	1.09	DNR_24_DD_up
24	14	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	2.31e-06	7.26e-08	4470	40.6	9530	37.4	1.09	DNR_24_DD_up
25	6	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	3.39e-06	1.02e-07	2520	22.8	5140	20.1	1.13	DNR_24_DD_up
26	15	MA1596.1 (ZNF460)	STREME-2	2-GGCCTCCC	GGCCTCCC	ZNF460	5.28e-06	1.53e-07	4290	38.9	9130	35.8	1.09	DNR_24_DD_up
27	4	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	6.32e-06	1.76e-07	2080	18.9	4190	16.4	1.15	DNR_24_DD_up
28	16	MA1587.1 (ZNF135)	STREME-7	7-AGGAGTTGGAGAC	AGGAGTTGGAGAC	ZNF135	8.55e-06	2.3e-07	101	0.92	105	0.41	2.23	DNR_24_DD_up
29	4	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	9.38e-06	2.43e-07	3620	32.9	7630	29.9	1.1	DNR_24_DD_up
30	4	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	1.36e-05	3.42e-07	2380	21.6	4860	19	1.13	DNR_24_DD_up
31	4	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	2.73e-05	6.64e-07	5220	47.4	11300	44.3	1.07	DNR_24_DD_up
32	17	MA1728.1	ZNF549	MA1728.1	NNTGCTGCCCWR	ZNF549	3.24e-05	7.63e-07	3580	32.4	7560	29.6	1.1	DNR_24_DD_up
33	18	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	3.49e-05	7.96e-07	3540	32.1	7480	29.3	1.1	DNR_24_DD_up
34	19	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	7.54e-05	1.67e-06	3410	31	7200	28.2	1.1	DNR_24_DD_up
35	20	GCTGGGATTACAGGC	MEME-2	GCTGGGATTACAGGC	GCTGGGATTACAGGC	GCTGGGATTACAGGC	0.000123	2.64e-06	2600	23.6	5400	21.2	1.12	DNR_24_DD_up
36	21	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	0.000138	2.88e-06	3830	34.8	8170	32	1.09	DNR_24_DD_up
37	22	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	0.000151	3.07e-06	5640	51.2	12300	48.3	1.06	DNR_24_DD_up
38	23	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	0.000205	4.07e-06	6130	55.6	13500	52.8	1.05	DNR_24_DD_up
39	10	MA0750.2	ZBTB7A	MA0750.2	NVCCGGAAGTGSV	ZBTB7A	0.000233	4.51e-06	3430	31.1	7280	28.5	1.09	DNR_24_DD_up
40	24	MA1629.1	Zic2	MA1629.1	NDCACAGCAGGDRG	Zic2	0.000294	5.53e-06	8870	80.5	20000	78.2	1.03	DNR_24_DD_up
41	9	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	0.000351	6.44e-06	7350	66.7	16300	64	1.04	DNR_24_DD_up
42	4	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	0.000422	7.56e-06	5170	46.9	11300	44.1	1.06	DNR_24_DD_up
43	4	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	0.000577	1.01e-05	637	5.78	1160	4.57	1.27	DNR_24_DD_up
44	25	MA0736.1	GLIS2	MA0736.1	GACCCCCCGCRAMG	GLIS2	0.000666	1.14e-05	3280	29.8	6960	27.3	1.09	DNR_24_DD_up
45	26	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	0.000777	1.28e-05	2470	22.4	5150	20.2	1.11	DNR_24_DD_up
46	4	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	0.000782	1.28e-05	2520	22.9	5270	20.7	1.11	DNR_24_DD_up
47	2	MA1973.1	ZKSCAN3	MA1973.1	KDKCCCAGGCTAGCCCABNN	ZKSCAN3	0.000805	1.29e-05	1690	15.3	3420	13.4	1.14	DNR_24_DD_up
48	4	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	0.00082	1.29e-05	2020	18.3	4140	16.2	1.13	DNR_24_DD_up
49	27	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	0.000854	1.31e-05	6520	59.1	14400	56.4	1.05	DNR_24_DD_up
12	11	MA1125.1 (ZNF384)	MEME-5	WAAWAAAAAAAAAAA	WAAWAAAAAAAAAAA	ZNF384	0.000958	7.98e-05	708	6.43	1380	5.4	1.19	DNR_24_DD_up
50	27	MA0067.2	PAX2	MA0067.2	BCAVTSRAGCGTGACGR	PAX2	0.000981	1.47e-05	2790	25.4	5880	23	1.1	DNR_24_DD_up
51	28	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	0.000996	1.47e-05	5780	52.4	12700	49.7	1.05	DNR_24_DD_up
52	4	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	0.00145	2.1e-05	5340	48.5	11700	45.8	1.06	DNR_24_DD_up
53	29	MA1966.1	TFAP4::ETV1	MA1966.1	RSCGGAAGCAGSTGKN	TFAP4::ETV1	0.00152	2.15e-05	4560	41.4	9900	38.8	1.07	DNR_24_DD_up
54	24	MA0697.2	Zic3	MA0697.2	CNCAGCAGGAGNN	Zic3	0.00162	2.26e-05	8670	78.7	19500	76.5	1.03	DNR_24_DD_up
55	24	MA0751.1	ZIC4	MA0751.1	GRCCCCCCGCKGYGH	ZIC4	0.00238	3.25e-05	3930	35.7	8480	33.2	1.07	DNR_24_DD_up
56	30	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	0.00251	3.37e-05	3730	33.9	8030	31.5	1.08	DNR_24_DD_up
57	20	MA0783.1 (PKNOX2)	STREME-8	8-ACACCTGTAAT	ACACCTGTAAT	PKNOX2	0.00307	4.06e-05	483	4.38	867	3.4	1.29	DNR_24_DD_up
58	31	MA1982.1	ZNF574	MA1982.1	VGSCTAGAGMGGCCS	ZNF574	0.00334	4.33e-05	6080	55.2	13400	52.6	1.05	DNR_24_DD_up
59	10	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	0.00377	4.74e-05	2270	20.6	4740	18.6	1.11	DNR_24_DD_up
60	28	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	0.00378	4.74e-05	4040	36.6	8730	34.2	1.07	DNR_24_DD_up
61	4	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	0.00402	4.96e-05	407	3.69	715	2.8	1.32	DNR_24_DD_up
62	10	MA0765.3	ETV5	MA0765.3	ACCGGAAGTR	ETV5	0.00454	5.52e-05	3010	27.3	6400	25.1	1.09	DNR_24_DD_up
63	32	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	0.00562	6.72e-05	7050	64	15700	61.6	1.04	DNR_24_DD_up
64	10	MA0764.3	ETV4	MA0764.3	ACCGGAAGTR	ETV4	0.00782	9.15e-05	3250	29.5	6960	27.3	1.08	DNR_24_DD_up
65	10	MA0156.3	FEV	MA0156.3	VACCGGAAGTVV	FEV	0.0079	9.15e-05	3000	27.2	6410	25.1	1.09	DNR_24_DD_up
66	4	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	0.00973	0.000111	367	3.33	643	2.52	1.32	DNR_24_DD_up
67	33	MA1655.1	ZNF341	MA1655.1	NRGAACAGCCNN	ZNF341	0.0132	0.000148	6810	61.8	15200	59.5	1.04	DNR_24_DD_up
68	29	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	0.0133	0.000148	2680	24.3	5690	22.3	1.09	DNR_24_DD_up
69	33	MA1730.1	ZNF708	MA1730.1	NNRGCTGTRCCTCCY	ZNF708	0.0136	0.000148	5880	53.4	13000	51	1.05	DNR_24_DD_up
70	34	MA0597.2	THAP1	MA0597.2	VSGCAGGGCASV	THAP1	0.0153	0.000165	4500	40.8	9820	38.5	1.06	DNR_24_DD_up
71	4	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	0.016	0.00017	2380	21.6	5020	19.7	1.1	DNR_24_DD_up
72	35	MA1971.1	ZBED2	MA1971.1	NNMMCGAAACCNNV	ZBED2	0.0169	0.000177	500	4.54	922	3.61	1.26	DNR_24_DD_up
73	36	MA1652.1	ZKSCAN5	MA1652.1	NNRGGARGTGAGRR	ZKSCAN5	0.0172	0.000177	7910	71.8	17800	69.6	1.03	DNR_24_DD_up
74	16	MA1587.1	ZNF135	MA1587.1	CCTCGACCTCCYRR	ZNF135	0.0191	0.000194	2880	26.2	6160	24.2	1.08	DNR_24_DD_up
75	8	MA0155.1	INSM1	MA0155.1	TGYCWGGGGGCR	INSM1	0.0214	0.000214	2520	22.9	5350	21	1.09	DNR_24_DD_up
76	37	MA0145.2	Tfcp2l1	MA0145.2	CCAGYYYVADCCRG	Tfcp2l1	0.0216	0.000214	557	5.05	1040	4.09	1.24	DNR_24_DD_up
77	32	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	0.0234	0.000229	3430	31.1	7400	29	1.07	DNR_24_DD_up
78	4	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	0.0278	0.000268	9980	90.6	22800	89.2	1.02	DNR_24_DD_up
79	23	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	0.0285	0.000272	1910	17.4	4000	15.7	1.11	DNR_24_DD_up
80	29	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	0.0289	0.000272	4190	38	9150	35.8	1.06	DNR_24_DD_up
81	29	MA1631.1	ASCL1	MA1631.1	NNGCACCTGCYNB	ASCL1	0.0313	0.000291	1380	12.5	2820	11	1.13	DNR_24_DD_up
82	4	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	0.0386	0.000352	6620	60.1	14800	57.9	1.04	DNR_24_DD_up
83	4	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	0.0388	0.000352	5490	49.9	12200	47.6	1.05	DNR_24_DD_up
84	38	MA0154.4	EBF1	MA0154.4	NNTCCCCAGGGGANN	EBF1	0.0445	0.000399	7030	63.8	15700	61.7	1.03	DNR_24_DD_up
13	39	MA1107.2 (KLF9)	MEME-6	GTGTGTGTGTGTGT	GTGTGTGTGTGTGT	KLF9	14	1	647	5.87	1740	6.8	0.864	DNR_24_DD_up
14	40	MA1138.1 (FOSL2::JUNB)	MEME-1	TGASTCATYHH	TGASTCATYHH	FOSL2::JUNB	14	1	2340	21.2	6000	23.5	0.903	DNR_24_DD_up

ER_rat <- 1.25

DNR_24_DD_up_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DNR_24_DD_up_combo response peaks(200bp)Enrichment ratio:",ER_rat))

DNR_24_DD_up_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DNR_24_DD_up_combo response peaks(200bp)Enrichment ratio:",ER_rat))

DNR 24_down hour

DNR_24_DD_down_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_DEG_24_down_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
DNR_24_DD_down_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_DEG_24_down_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
DNR_24_DD_down_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/DNR_DEG_24_down_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
DNR_24_DD_down_sea_all <- rbind(DNR_24_DD_down_sea_disc, DNR_24_DD_down_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

DNR_24_DD_down_combo <- DNR_24_DD_down_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., DNR_24_DD_down_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="DNR_24_DD_down")

DNR_24_DD_down_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "DNR_24_DD_down DNR enriched motifs") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

DNR_24_DD_down DNR enriched motifs
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA1513.1 (KLF15)	STREME-1	1-SGCCCGCCSCS	SGCCCGCCSCS	KLF15	2.08e-113	1.01e-113	2410	23	1800	12	1.91	DNR_24_DD_down
2	2	MA0079.5 (SP1)	MEME-1	CSCCSSCCCCGCCCC	CSCCSSCCCCGCCCC	SP1	2.93e-113	1.01e-113	2580	24.6	1990	13.3	1.85	DNR_24_DD_down
3	2	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	9.57e-92	2.2e-92	2920	27.8	2540	16.9	1.64	DNR_24_DD_down
4	3	4-CGSSCG	STREME-4	4-CGSSCG	CGSSCG	CGSSCG	3.11e-91	5.36e-92	2030	19.3	1520	10.2	1.9	DNR_24_DD_down
5	4	MA1650.1	ZBTB14	MA1650.1	SSCCGCGCACVS	ZBTB14	3.74e-81	5.16e-82	3910	37.2	3860	25.8	1.44	DNR_24_DD_down
6	2	MA0146.2 (Zfx)	STREME-2	2-AGCGGCGGCCBSG	AGCGGCGGCCBSG	Zfx	2.77e-79	3.19e-80	3870	36.8	3830	25.6	1.44	DNR_24_DD_down
7	5	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	1.82e-78	1.8e-79	1980	18.8	1550	10.3	1.82	DNR_24_DD_down
8	17	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	7.6e-74	6.56e-75	3390	32.3	3280	21.9	1.48	DNR_24_DD_down
9	6	6-SCSSGS	STREME-6	6-SCSSGS	SCSSGS	SCSSGS	1.23e-72	9.41e-74	4120	39.2	4220	28.2	1.39	DNR_24_DD_down
10	2	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	8.01e-71	5.53e-72	3200	30.5	3070	20.5	1.49	DNR_24_DD_down
11	10	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	5.65e-70	3.55e-71	3520	33.5	3480	23.2	1.44	DNR_24_DD_down
12	2	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	8.02e-67	4.62e-68	4640	44.1	4980	33.2	1.33	DNR_24_DD_down
13	7	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	5.5e-64	2.92e-65	2430	23.2	2190	14.6	1.58	DNR_24_DD_down
14	8	MA0471.2	E2F6	MA0471.2	VVDGGCGGGAAVV	E2F6	7.36e-64	3.63e-65	3210	30.6	3150	21	1.45	DNR_24_DD_down
15	2	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	1.91e-61	8.78e-63	3150	30	3100	20.7	1.45	DNR_24_DD_down
16	9	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	2.52e-61	1.09e-62	3470	33	3500	23.4	1.41	DNR_24_DD_down
17	10	MA1522.1 (MAZ)	STREME-5	5-CCCCTCC	CCCCTCC	MAZ	1.01e-60	4.08e-62	3260	31	3240	21.6	1.43	DNR_24_DD_down
18	11	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	2.95e-60	1.13e-61	2680	25.4	2520	16.8	1.51	DNR_24_DD_down
19	12	3-CGGSCCG	STREME-3	3-CGGSCCG	CGGSCCG	CGGSCCG	2.19e-57	7.97e-59	6010	57.2	7010	46.8	1.22	DNR_24_DD_down
20	8	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	3.12e-57	1.08e-58	3730	35.5	3880	25.9	1.37	DNR_24_DD_down
21	2	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	1.56e-56	5.14e-58	3830	36.4	4030	26.9	1.36	DNR_24_DD_down
22	7	MA0039.4	KLF4	MA0039.4	NNCCCCACCCHN	KLF4	1.89e-55	5.93e-57	4230	40.2	4570	30.5	1.32	DNR_24_DD_down
23	7	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	1.59e-54	4.78e-56	1990	18.9	1750	11.7	1.62	DNR_24_DD_down
24	7	MA0732.1	EGR3	MA0732.1	HHMCGCCCACGCAHH	EGR3	5.45e-54	1.57e-55	1970	18.8	1740	11.6	1.62	DNR_24_DD_down
25	7	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	1.15e-53	3.18e-55	4090	38.9	4410	29.4	1.32	DNR_24_DD_down
26	7	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	1.84e-53	4.89e-55	4750	45.2	5300	35.4	1.28	DNR_24_DD_down
27	7	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	3.18e-53	8.13e-55	3840	36.5	4070	27.2	1.34	DNR_24_DD_down
28	7	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	7.01e-53	1.73e-54	2610	24.9	2520	16.8	1.48	DNR_24_DD_down
29	7	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	4.92e-52	1.17e-53	3720	35.4	3940	26.3	1.35	DNR_24_DD_down
30	13	MA0864.2	E2F2	MA0864.2	RWTTTGGCGCCAWWWY	E2F2	8.22e-52	1.89e-53	2320	22.1	2170	14.5	1.52	DNR_24_DD_down
31	14	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	1.62e-51	3.61e-53	4780	45.4	5360	35.8	1.27	DNR_24_DD_down
32	15	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	6.43e-51	1.39e-52	3430	32.6	3570	23.8	1.37	DNR_24_DD_down
33	16	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	7.02e-51	1.47e-52	4400	41.8	4850	32.4	1.29	DNR_24_DD_down
34	2	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	2.06e-50	4.18e-52	3100	29.5	3160	21.1	1.4	DNR_24_DD_down
35	2	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	2.8e-50	5.52e-52	1850	17.6	1620	10.8	1.62	DNR_24_DD_down
36	7	MA0746.2	SP3	MA0746.2	NGCCACGCCCMCH	SP3	3.03e-49	5.82e-51	3680	35	3920	26.2	1.34	DNR_24_DD_down
37	17	MA1713.1 (ZNF610)	STREME-7	7-CGCTCC	CGCTCC	ZNF610	7.5e-49	1.4e-50	4560	43.3	5090	34	1.27	DNR_24_DD_down
38	2	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	1.26e-48	2.3e-50	5260	50	6070	40.5	1.24	DNR_24_DD_down
39	18	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	3.64e-48	6.44e-50	3840	36.6	4150	27.7	1.32	DNR_24_DD_down
40	2	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	1.79e-47	3.09e-49	4130	39.3	4540	30.3	1.3	DNR_24_DD_down
41	2	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	2.08e-47	3.5e-49	4760	45.3	5390	36	1.26	DNR_24_DD_down
42	7	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	6.69e-47	1.1e-48	5290	50.3	6130	40.9	1.23	DNR_24_DD_down
43	13	MA0024.3	E2F1	MA0024.3	TTTGGCGCCAAA	E2F1	1.21e-46	1.94e-48	1970	18.7	1800	12	1.56	DNR_24_DD_down
44	19	MA1985.1	ZNF669	MA1985.1	GGGGYGAYGACCRCT	ZNF669	1.04e-45	1.64e-47	3950	37.6	4330	28.9	1.3	DNR_24_DD_down
45	14	MA1723.1	PRDM9	MA1723.1	RGDGGGVAGGGRGGVRRMARVARR	PRDM9	2.42e-45	3.71e-47	4940	47	5670	37.8	1.24	DNR_24_DD_down
46	13	MA1615.1	Plagl1	MA1615.1	NNCTGGGGCCABN	Plagl1	3.69e-45	5.54e-47	3650	34.8	3940	26.3	1.32	DNR_24_DD_down
47	7	MA1107.2	KLF9	MA1107.2	MNGCCACACCCACHYV	KLF9	4.09e-44	6e-46	2460	23.4	2420	16.2	1.45	DNR_24_DD_down
48	20	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	1.11e-43	1.6e-45	3410	32.4	3640	24.3	1.34	DNR_24_DD_down
49	7	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	3.02e-43	4.26e-45	6460	61.4	7860	52.5	1.17	DNR_24_DD_down
50	8	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	5.2e-43	7.18e-45	1570	15	1370	9.13	1.64	DNR_24_DD_down
51	21	MA0810.1	TFAP2A	MA0810.1	YGCCCBVRGGCR	TFAP2A	5.91e-43	8e-45	1810	17.2	1650	11	1.57	DNR_24_DD_down
52	2	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	1.55e-42	2.06e-44	1620	15.4	1430	9.54	1.62	DNR_24_DD_down
53	7	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	2.35e-42	3.06e-44	2210	21	2130	14.2	1.48	DNR_24_DD_down
54	22	MA1548.1	PLAGL2	MA1548.1	NGGGCCCCCN	PLAGL2	1.32e-41	1.69e-43	5320	50.6	6260	41.8	1.21	DNR_24_DD_down
55	7	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	1.33e-40	1.67e-42	5130	48.8	6010	40.1	1.22	DNR_24_DD_down
56	23	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	2.72e-40	3.36e-42	4900	46.7	5700	38	1.23	DNR_24_DD_down
57	24	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	3.49e-40	4.22e-42	5530	52.6	6580	43.9	1.2	DNR_24_DD_down
58	20	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	4.99e-40	5.94e-42	1700	16.1	1540	10.3	1.57	DNR_24_DD_down
59	25	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	5.62e-40	6.58e-42	5760	54.8	6910	46.1	1.19	DNR_24_DD_down
60	26	MA0751.1	ZIC4	MA0751.1	GRCCCCCCGCKGYGH	ZIC4	1.13e-38	1.3e-40	4220	40.1	4780	31.9	1.26	DNR_24_DD_down
61	27	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	2.31e-38	2.61e-40	4260	40.6	4850	32.4	1.25	DNR_24_DD_down
62	7	MA0747.1	SP8	MA0747.1	RCCACGCCCMCY	SP8	2.46e-38	2.74e-40	2430	23.1	2450	16.3	1.41	DNR_24_DD_down
63	2	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	7.01e-38	7.68e-40	1840	17.5	1740	11.6	1.51	DNR_24_DD_down
64	28	9-CGGART	STREME-9	9-CGGART	CGGART	CGGART	3.3e-37	3.56e-39	4580	43.5	5300	35.3	1.23	DNR_24_DD_down
65	7	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	4.54e-37	4.82e-39	5630	53.6	6770	45.2	1.19	DNR_24_DD_down
66	29	MA0750.2	ZBTB7A	MA0750.2	NVCCGGAAGTGSV	ZBTB7A	6.31e-37	6.61e-39	2130	20.3	2100	14	1.45	DNR_24_DD_down
67	21	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	6.59e-37	6.79e-39	2360	22.4	2380	15.9	1.41	DNR_24_DD_down
68	8	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	1.38e-36	1.4e-38	6670	63.5	8290	55.3	1.15	DNR_24_DD_down
69	29	MA0131.2	HINFP	MA0131.2	CARCGTCCGCKN	HINFP	1.47e-36	1.47e-38	5730	54.5	6920	46.2	1.18	DNR_24_DD_down
70	26	MA1578.1	VEZF1	MA1578.1	CCCCCCMYDH	VEZF1	3.29e-35	3.24e-37	5030	47.8	5950	39.7	1.2	DNR_24_DD_down
71	13	MA0470.2	E2F4	MA0470.2	TTTTGGCGCCAWWW	E2F4	9.69e-35	9.42e-37	1380	13.2	1220	8.18	1.61	DNR_24_DD_down
72	13	MA1727.1	ZNF417	MA1727.1	VRBVNTGGGCGCCAM	ZNF417	2.51e-34	2.4e-36	3400	32.4	3750	25	1.29	DNR_24_DD_down
73	7	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	3.31e-34	3.13e-36	4920	46.9	5820	38.9	1.21	DNR_24_DD_down
74	29	MA0759.2	ELK3	MA0759.2	ACCGGAAGTRV	ELK3	3.84e-34	3.58e-36	2380	22.6	2440	16.3	1.39	DNR_24_DD_down
75	30	MA0694.1	ZBTB7B	MA0694.1	RCGACCACCGAA	ZBTB7B	1.1e-33	1.01e-35	4950	47.1	5870	39.2	1.2	DNR_24_DD_down
76	20	MA1106.1	HIF1A	MA1106.1	SBACGTGCNN	HIF1A	2.28e-33	2.07e-35	5380	51.1	6470	43.2	1.18	DNR_24_DD_down
77	7	MA0599.1	KLF5	MA0599.1	GCCCCDCCCH	KLF5	5.43e-33	4.87e-35	2860	27.2	3070	20.5	1.33	DNR_24_DD_down
78	8	MA0528.2	ZNF263	MA0528.2	VNGGGGAGGASG	ZNF263	7.51e-33	6.65e-35	4870	46.4	5780	38.6	1.2	DNR_24_DD_down
79	31	MA0597.2	THAP1	MA0597.2	VSGCAGGGCASV	THAP1	6.68e-31	5.84e-33	5200	49.5	6270	41.8	1.18	DNR_24_DD_down
80	32	MA0014.3	PAX5	MA0014.3	RRGCGTGACCNN	PAX5	8.89e-31	7.67e-33	4480	42.6	5260	35.1	1.21	DNR_24_DD_down
81	21	MA1569.1	TFAP2E	MA1569.1	YGCCYSRGGCD	TFAP2E	1.93e-30	1.65e-32	2100	19.9	2130	14.2	1.4	DNR_24_DD_down
82	21	MA0811.1	TFAP2B	MA0811.1	YGCCCBVRGGCA	TFAP2B	6.7e-30	5.64e-32	1980	18.8	1990	13.3	1.42	DNR_24_DD_down
83	20	MA0649.1	HEY2	MA0649.1	GRCACGTGYC	HEY2	1.12e-29	9.28e-32	4200	39.9	4900	32.7	1.22	DNR_24_DD_down
84	20	MA0821.2	HES5	MA0821.2	GRCACGTGYC	HES5	1.76e-29	1.45e-31	1040	9.94	888	5.93	1.68	DNR_24_DD_down
85	20	MA0259.1	ARNT::HIF1A	MA0259.1	VBACGTGC	ARNT::HIF1A	4.6e-28	3.74e-30	3870	36.8	4480	29.9	1.23	DNR_24_DD_down
86	30	MA0734.3	Gli2	MA0734.3	NRGACCACCCASV	Gli2	8.06e-28	6.47e-30	4660	44.3	5560	37.1	1.19	DNR_24_DD_down
87	8	MA1987.1	ZNF701	MA1987.1	GAGCACYAARGGGGGRADDDD	ZNF701	3.9e-27	3.1e-29	5870	55.8	7290	48.6	1.15	DNR_24_DD_down
88	21	MA0812.1	TFAP2B	MA0812.1	HGCCTSAGGCD	TFAP2B	5.42e-27	4.25e-29	5520	52.5	6790	45.3	1.16	DNR_24_DD_down
89	20	MA1099.2	HES1	MA1099.2	GGCRCGTGBC	HES1	6.07e-27	4.71e-29	777	7.39	613	4.09	1.81	DNR_24_DD_down
90	13	MA0615.1	Gmeb1	MA0615.1	BHBBKKACGTMMNWNNN	Gmeb1	1.04e-26	7.98e-29	5760	54.8	7130	47.6	1.15	DNR_24_DD_down
91	21	MA0815.1	TFAP2C	MA0815.1	TGCCCYSRGGGCA	TFAP2C	2.98e-26	2.26e-28	2630	25	2870	19.1	1.31	DNR_24_DD_down
92	21	MA0872.1	TFAP2A	MA0872.1	TGCCCYSRGGGCA	TFAP2A	8.95e-26	6.71e-28	1690	16.1	1690	11.3	1.43	DNR_24_DD_down
93	29	MA1966.1	TFAP4::ETV1	MA1966.1	RSCGGAAGCAGSTGKN	TFAP4::ETV1	3.13e-25	2.32e-27	1720	16.3	1730	11.6	1.42	DNR_24_DD_down
94	20	MA0830.2	TCF4	MA0830.2	NNGCACCTGCCNN	TCF4	1.32e-24	9.72e-27	5620	53.5	6980	46.6	1.15	DNR_24_DD_down
95	33	MA1973.1	ZKSCAN3	MA1973.1	KDKCCCAGGCTAGCCCABNN	ZKSCAN3	5.31e-24	3.86e-26	4370	41.6	5240	34.9	1.19	DNR_24_DD_down
96	20	MA0006.1	Ahr::Arnt	MA0006.1	YGCGTG	Ahr::Arnt	1.66e-23	1.19e-25	1940	18.4	2030	13.5	1.36	DNR_24_DD_down
97	26	MA0696.1	ZIC1	MA0696.1	GACCCCCYGCTGTG	ZIC1	3.02e-23	2.15e-25	1710	16.3	1750	11.7	1.4	DNR_24_DD_down
98	20	MA0522.3	TCF3	MA0522.3	NVCACCTGCNN	TCF3	3.51e-23	2.48e-25	4460	42.4	5380	35.9	1.18	DNR_24_DD_down
99	20	MA0616.2	HES2	MA0616.2	GGCACGTGYC	HES2	7.09e-23	4.95e-25	989	9.41	885	5.91	1.59	DNR_24_DD_down
100	21	MA0813.1	TFAP2B	MA0813.1	TGCCCYBRGGGCA	TFAP2B	7.28e-23	5.03e-25	2420	23.1	2660	17.7	1.3	DNR_24_DD_down
101	32	MA0067.2	PAX2	MA0067.2	BCAVTSRAGCGTGACGR	PAX2	9.39e-23	6.42e-25	2250	21.4	2430	16.2	1.32	DNR_24_DD_down
102	20	MA1464.1	ARNT2	MA1464.1	GTCACGTGMN	ARNT2	1.01e-22	6.82e-25	3680	35	4320	28.8	1.21	DNR_24_DD_down
103	34	MA1628.1	Zic1::Zic2	MA1628.1	CVCAGCAGGNV	Zic1::Zic2	3.26e-22	2.19e-24	5380	51.2	6690	44.6	1.15	DNR_24_DD_down
104	26	MA0736.1	GLIS2	MA0736.1	GACCCCCCGCRAMG	GLIS2	5.18e-22	3.44e-24	1930	18.4	2040	13.6	1.35	DNR_24_DD_down
105	26	MA1584.1	ZIC5	MA1584.1	VGACCCCCCGCTGHGM	ZIC5	1.02e-21	6.72e-24	1540	14.6	1560	10.4	1.41	DNR_24_DD_down
106	35	MA1656.1	ZNF449	MA1656.1	NNAAGCCCAACCNN	ZNF449	2.17e-21	1.41e-23	5940	56.6	7510	50.1	1.13	DNR_24_DD_down
107	20	MA0104.4	MYCN	MA0104.4	VVCCACGTGGBB	MYCN	5.02e-21	3.24e-23	3100	29.5	3580	23.9	1.24	DNR_24_DD_down
108	18	MA1929.1	CTCF	MA1929.1	CTGCAGTKCCNNNNNYNRCCASYAGRKGGCRSWG	CTCF	9.19e-21	5.88e-23	5740	54.6	7240	48.3	1.13	DNR_24_DD_down
109	36	MA1941.1	ETV2::FIGLA	MA1941.1	RSCGGAARCAGSTGBN	ETV2::FIGLA	1.52e-20	9.63e-23	2090	19.9	2260	15.1	1.32	DNR_24_DD_down
110	37	MA1719.1	ZNF816	MA1719.1	DRRKGGGGACATGCHGGG	ZNF816	1.76e-20	1.11e-22	5140	48.9	6380	42.6	1.15	DNR_24_DD_down
111	38	MA1149.1	RARA::RXRG	MA1149.1	RRGGTCAHNNNRRGGTCA	RARA::RXRG	2.59e-20	1.61e-22	6090	58	7750	51.7	1.12	DNR_24_DD_down
112	39	MA1684.1	Foxn1	MA1684.1	RGAMGC	Foxn1	6.64e-20	4.09e-22	1440	13.7	1460	9.73	1.41	DNR_24_DD_down
113	40	MA1599.1	ZNF682	MA1599.1	BVGGCYAAGCCCCWNY	ZNF682	9.75e-20	5.96e-22	814	7.74	715	4.77	1.62	DNR_24_DD_down
114	9	MA1587.1	ZNF135	MA1587.1	CCTCGACCTCCYRR	ZNF135	1.22e-19	7.42e-22	4360	41.4	5310	35.4	1.17	DNR_24_DD_down
115	25	MA0003.4	TFAP2A	MA0003.4	NNKGCCTCAGGCNN	TFAP2A	4.89e-19	2.94e-21	6730	64	8700	58.1	1.1	DNR_24_DD_down
116	41	MA0528.2 (ZNF263)	STREME-8	8-GGACGARGA	GGACGARGA	ZNF263	7.47e-19	4.42e-21	1730	16.4	1830	12.2	1.35	DNR_24_DD_down
117	20	MA1474.1	CREB3L4	MA1474.1	YGCCACGTCAYC	CREB3L4	7.49e-19	4.42e-21	6560	62.4	8460	56.5	1.11	DNR_24_DD_down
118	20	MA1631.1	ASCL1	MA1631.1	NNGCACCTGCYNB	ASCL1	7.88e-19	4.61e-21	5140	49	6430	42.9	1.14	DNR_24_DD_down
119	20	MA1560.1	SOHLH2	MA1560.1	YGCACGTGCN	SOHLH2	1.92e-18	1.11e-20	1560	14.8	1620	10.8	1.37	DNR_24_DD_down
120	20	MA1648.1	TCF12	MA1648.1	NNCACCTGCNN	TCF12	7.17e-18	4.12e-20	5790	55.1	7370	49.2	1.12	DNR_24_DD_down
121	14	MA0163.1	PLAG1	MA0163.1	GGGGCCCWAGGGGG	PLAG1	7.83e-18	4.47e-20	1360	12.9	1390	9.25	1.4	DNR_24_DD_down
122	30	MA1990.1	Gli1	MA1990.1	NNRGACCACCCASV	Gli1	1.54e-17	8.7e-20	3440	32.8	4100	27.4	1.2	DNR_24_DD_down
123	18	MA1930.1	CTCF	MA1930.1	CTGCAGTKCCNVCHNNYRGCCASYAGRKGGCRAKC	CTCF	1.71e-17	9.62e-20	2090	19.9	2310	15.4	1.29	DNR_24_DD_down
124	20	MA1945.1	ETV5::FIGLA	MA1945.1	RGCGGAARCAGGTGG	ETV5::FIGLA	1.04e-16	5.79e-19	3200	30.5	3800	25.4	1.2	DNR_24_DD_down
125	29	MA0765.3	ETV5	MA0765.3	ACCGGAAGTR	ETV5	1.21e-16	6.66e-19	2770	26.3	3220	21.5	1.23	DNR_24_DD_down
126	29	MA0028.2	ELK1	MA0028.2	ACCGGAAGTR	ELK1	1.79e-16	9.79e-19	4750	45.2	5930	39.6	1.14	DNR_24_DD_down
127	34	MA1997.1	Olig2	MA1997.1	NVCAGCTGBN	Olig2	7.87e-16	4.28e-18	4020	38.2	4920	32.9	1.16	DNR_24_DD_down
128	42	MA1716.1	ZNF76	MA1716.1	NNTWCCCAYAATGCAHYGCGC	ZNF76	9.93e-16	5.36e-18	3290	31.3	3940	26.3	1.19	DNR_24_DD_down
129	43	MA1982.1	ZNF574	MA1982.1	VGSCTAGAGMGGCCS	ZNF574	1.45e-15	7.78e-18	3640	34.6	4410	29.5	1.18	DNR_24_DD_down
130	44	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	4.91e-15	2.61e-17	934	8.89	905	6.04	1.47	DNR_24_DD_down
131	29	MA0764.3	ETV4	MA0764.3	ACCGGAAGTR	ETV4	1.02e-14	5.35e-17	2670	25.4	3130	20.9	1.22	DNR_24_DD_down
132	34	MA1993.1	Neurod2	MA1993.1	VVCAGCTGBB	Neurod2	1.29e-14	6.73e-17	4070	38.7	5030	33.6	1.15	DNR_24_DD_down
133	30	MA0695.1	ZBTB7C	MA0695.1	RCGACCACCGAN	ZBTB7C	1.58e-14	8.22e-17	9360	89.1	12800	85.5	1.04	DNR_24_DD_down
134	45	MA1533.1	NR1I2	MA1533.1	DYGAACTSVDTGAACTC	NR1I2	2.07e-14	1.07e-16	4960	47.1	6270	41.8	1.13	DNR_24_DD_down
135	46	MA1710.1	ZNF257	MA1710.1	VDGAGGCRAGRG	ZNF257	2.12e-14	1.08e-16	6360	60.5	8280	55.2	1.1	DNR_24_DD_down
136	20	MA0103.3	ZEB1	MA0103.3	SNCACCTGSVN	ZEB1	2.82e-14	1.43e-16	3420	32.5	4140	27.7	1.18	DNR_24_DD_down
137	47	MA0511.2	RUNX2	MA0511.2	WAACCGCAA	RUNX2	3.17e-14	1.6e-16	7520	71.5	9980	66.6	1.07	DNR_24_DD_down
138	34	MA0633.2	Twist2	MA0633.2	NVCAGCTGBN	Twist2	9.5e-14	4.75e-16	3990	38	4940	33	1.15	DNR_24_DD_down
139	26	MA0697.2	Zic3	MA0697.2	CNCAGCAGGAGNN	Zic3	8.33e-13	4.14e-15	3540	33.6	4340	28.9	1.16	DNR_24_DD_down
140	20	MA0603.1	Arntl	MA0603.1	NGTCACGTGH	Arntl	1.27e-12	6.28e-15	6200	59	8100	54	1.09	DNR_24_DD_down
141	48	MA1971.1	ZBED2	MA1971.1	NNMMCGAAACCNNV	ZBED2	1.89e-12	9.23e-15	663	6.31	615	4.1	1.54	DNR_24_DD_down
142	49	MA1557.1	SMAD5	MA1557.1	YGTCTAGACA	SMAD5	2.18e-12	1.06e-14	4300	40.9	5400	36.1	1.13	DNR_24_DD_down
143	50	MA1637.1	EBF3	MA1637.1	NYCCCAAGGGANN	EBF3	3.26e-12	1.58e-14	5410	51.5	6970	46.5	1.11	DNR_24_DD_down
144	18	MA0155.1	INSM1	MA0155.1	TGYCWGGGGGCR	INSM1	7.92e-12	3.8e-14	2590	24.6	3080	20.6	1.2	DNR_24_DD_down
145	20	MA1934.1	ERF::FIGLA	MA1934.1	RCCGGAARCASCTGBN	ERF::FIGLA	9.04e-12	4.31e-14	2350	22.3	2760	18.4	1.21	DNR_24_DD_down
146	26	MA1629.1	Zic2	MA1629.1	NDCACAGCAGGDRG	Zic2	9.92e-12	4.69e-14	7510	71.4	10000	66.9	1.07	DNR_24_DD_down
147	18	MA0139.1	CTCF	MA0139.1	YGRCCASYAGRKGGCRSYR	CTCF	1.03e-11	4.83e-14	4600	43.8	5840	39	1.12	DNR_24_DD_down
148	51	MA1730.1	ZNF708	MA1730.1	NNRGCTGTRCCTCCY	ZNF708	1.21e-11	5.63e-14	2900	27.6	3500	23.4	1.18	DNR_24_DD_down
149	52	MA1545.1	OVOL2	MA1545.1	DDACCGTTABNYN	OVOL2	2.2e-11	1.02e-13	1920	18.3	2210	14.7	1.24	DNR_24_DD_down
150	53	MA0646.1	GCM1	MA0646.1	BATGCGGGTAC	GCM1	2.27e-11	1.05e-13	7770	73.9	10400	69.6	1.06	DNR_24_DD_down
151	20	MA0004.1	Arnt	MA0004.1	CACGTG	Arnt	8.47e-11	3.87e-13	1560	14.9	1750	11.7	1.27	DNR_24_DD_down
152	20	MA1493.1	HES6	MA1493.1	GGCACGTGTY	HES6	9.22e-11	4.19e-13	2240	21.3	2640	17.6	1.21	DNR_24_DD_down
153	20	MA0464.2	BHLHE40	MA0464.2	VKCACGTGMC	BHLHE40	3.68e-10	1.66e-12	1580	15	1790	12	1.26	DNR_24_DD_down
154	54	MA1555.1	RXRB	MA1555.1	RRGGTCATGACCYY	RXRB	1.01e-09	4.51e-12	3540	33.7	4430	29.5	1.14	DNR_24_DD_down
155	34	MA1635.1	BHLHE22	MA1635.1	NVCAGCTGBN	BHLHE22	2.11e-09	9.38e-12	4380	41.7	5600	37.4	1.12	DNR_24_DD_down
156	38	MA0159.1	RARA::RXRA	MA0159.1	RGKTCANVGRSAGGTCA	RARA::RXRA	4.5e-09	1.99e-11	4850	46.1	6260	41.8	1.1	DNR_24_DD_down
157	55	MA1728.1	ZNF549	MA1728.1	NNTGCTGCCCWR	ZNF549	1.14e-08	5.01e-11	8530	81.1	11600	77.7	1.04	DNR_24_DD_down
158	56	MA1475.1	CREB3L4	MA1475.1	GRTGACGTCAYC	CREB3L4	2.41e-08	1.05e-10	1560	14.8	1800	12	1.24	DNR_24_DD_down
159	57	MA1711.1	ZNF343	MA1711.1	CCGCTTCMCCDCGGCMV	ZNF343	4.15e-08	1.8e-10	1860	17.7	2200	14.7	1.21	DNR_24_DD_down
160	36	MA1529.1	NHLH2	MA1529.1	GGGNCGCAGCTGCGYCCC	NHLH2	5.7e-08	2.46e-10	2500	23.7	3050	20.4	1.17	DNR_24_DD_down
161	56	MA0604.1	Atf1	MA0604.1	RTGACGTA	Atf1	5.78e-08	2.48e-10	2740	26.1	3380	22.6	1.16	DNR_24_DD_down
162	58	MA1972.1	ZFP14	MA1972.1	GGAGGCHCHGGARBG	ZFP14	1.25e-07	5.34e-10	3880	37	4960	33.1	1.12	DNR_24_DD_down
163	20	MA0608.1	Creb3l2	MA0608.1	GCCACGTGD	Creb3l2	1.65e-07	6.98e-10	3900	37.2	5000	33.3	1.11	DNR_24_DD_down
164	53	MA0767.1	GCM2	MA0767.1	BATGCGGGTR	GCM2	3.13e-07	1.32e-09	9800	93.3	13700	91.2	1.02	DNR_24_DD_down
165	50	MA1604.1	Ebf2	MA1604.1	NYCCCAAGGGANN	Ebf2	3.16e-07	1.32e-09	5890	56	7810	52.1	1.08	DNR_24_DD_down
166	59	MA1643.1	NFIB	MA1643.1	NNCCTGGCAYNGTGCCAAGNN	NFIB	9.05e-07	3.76e-09	3880	36.9	4980	33.2	1.11	DNR_24_DD_down
167	29	MA1933.1	ELK1::SREBF2	MA1933.1	DCCGGAAGTSRCGTGA	ELK1::SREBF2	9.56e-07	3.95e-09	672	6.39	698	4.66	1.37	DNR_24_DD_down
168	60	MA1521.1	MAFA	MA1521.1	NTGCTGASTCAGCAN	MAFA	1.89e-06	7.77e-09	1070	10.2	1200	8.04	1.27	DNR_24_DD_down
169	38	MA1536.1	NR2C2	MA1536.1	RRGGTCAN	NR2C2	2.43e-06	9.91e-09	420	4	400	2.67	1.5	DNR_24_DD_down
170	54	MA1147.1	NR4A2::RXRA	MA1147.1	VRGGTCRTTGACCYY	NR4A2::RXRA	2.45e-06	9.94e-09	4380	41.7	5700	38	1.1	DNR_24_DD_down
171	61	MA0138.2	REST	MA0138.2	TTCAGCACCATGGACAGCDCC	REST	2.55e-06	1.03e-08	2280	21.7	2810	18.7	1.16	DNR_24_DD_down
172	25	MA1581.1	ZBTB6	MA1581.1	DNSCTTGAGCCNV	ZBTB6	2.78e-06	1.12e-08	8710	82.9	12000	80	1.04	DNR_24_DD_down
173	29	MA0076.2	ELK4	MA0076.2	BCRCTTCCGGB	ELK4	4.97e-06	1.98e-08	258	2.45	218	1.45	1.69	DNR_24_DD_down
174	62	MA1542.1	OSR1	MA1542.1	HGCTACYGTD	OSR1	5.7e-06	2.26e-08	6880	65.5	9290	62	1.06	DNR_24_DD_down
175	59	MA1528.1	NFIX	MA1528.1	STTGGCRNNGTGCCARB	NFIX	9.23e-06	3.64e-08	2810	26.7	3540	23.6	1.13	DNR_24_DD_down
176	20	MA0147.3	MYC	MA0147.3	NNCCACGTGCNB	MYC	1.3e-05	5.11e-08	8940	85	12300	82.4	1.03	DNR_24_DD_down
177	63	MA1715.1	ZNF707	MA1715.1	CCCCACTCCTGGTAC	ZNF707	2.4e-05	9.37e-08	2580	24.6	3250	21.7	1.13	DNR_24_DD_down
178	29	MA0156.3	FEV	MA0156.3	VACCGGAAGTVV	FEV	2.69e-05	1.04e-07	1630	15.5	1960	13.1	1.18	DNR_24_DD_down
179	20	MA0636.1	BHLHE41	MA0636.1	RTCACGTGAC	BHLHE41	3.19e-05	1.23e-07	384	3.65	371	2.48	1.48	DNR_24_DD_down
180	20	MA0058.3	MAX	MA0058.3	AVCACGTGNY	MAX	8.36e-05	3.21e-07	4660	44.3	6150	41	1.08	DNR_24_DD_down
181	64	MA1999.1	Prdm5	MA1999.1	CBGTTCTCCATCTNN	Prdm5	0.000107	4.08e-07	5860	55.8	7860	52.5	1.06	DNR_24_DD_down
182	51	MA1655.1	ZNF341	MA1655.1	NRGAACAGCCNN	ZNF341	0.000119	4.5e-07	5740	54.6	7690	51.4	1.06	DNR_24_DD_down
183	65	MA0145.2	Tfcp2l1	MA0145.2	CCAGYYYVADCCRG	Tfcp2l1	0.000293	1.11e-06	9410	89.6	13100	87.5	1.02	DNR_24_DD_down
184	45	MA1146.1	NR1H4::RXRA	MA1146.1	GAGKTCATTGACCYB	NR1H4::RXRA	0.000493	1.85e-06	4290	40.8	5660	37.8	1.08	DNR_24_DD_down
185	56	MA0844.1	XBP1	MA0844.1	WDKGMCACGTCATC	XBP1	0.000999	3.73e-06	1040	9.86	1220	8.14	1.21	DNR_24_DD_down
186	38	MA1535.1	NR2C1	MA1535.1	NRRGGTCAN	NR2C1	0.00159	5.91e-06	5520	52.5	7430	49.6	1.06	DNR_24_DD_down
187	56	MA0609.2	CREM	MA0609.2	NNDGTGACGTCACHNN	CREM	0.00294	1.09e-05	1890	18	2370	15.8	1.14	DNR_24_DD_down
188	29	MA0645.1	ETV6	MA0645.1	MSCGGAAGTR	ETV6	0.00316	1.16e-05	104	0.99	75	0.5	1.97	DNR_24_DD_down
189	20	MA1621.1	Rbpjl	MA1621.1	NNVACACCTGTBNN	Rbpjl	0.00388	1.42e-05	992	9.44	1180	7.85	1.2	DNR_24_DD_down
190	66	MA0738.1	HIC2	MA0738.1	RTGCCCRSB	HIC2	0.00443	1.61e-05	7170	68.2	9830	65.6	1.04	DNR_24_DD_down
191	54	MA1552.1	RARB	MA1552.1	RAGGTCATGACCTY	RARB	0.00455	1.64e-05	2000	19	2530	16.9	1.13	DNR_24_DD_down
192	67	MA1731.1	ZNF768	MA1731.1	YBVCYBRSCCTCTCTGDG	ZNF768	0.00473	1.7e-05	1440	13.7	1770	11.8	1.16	DNR_24_DD_down
193	56	MA0839.1	CREB3L1	MA0839.1	VTGCCACGTCAYCA	CREB3L1	0.00482	1.73e-05	2690	25.6	3470	23.2	1.1	DNR_24_DD_down
194	36	MA1485.1	FERD3L	MA1485.1	GCRMCAGCTGTYAC	FERD3L	0.00524	1.86e-05	1580	15	1960	13.1	1.15	DNR_24_DD_down
195	68	MA1554.1	RFX7	MA1554.1	CGTTGCYAY	RFX7	0.00581	2.06e-05	719	6.84	825	5.51	1.24	DNR_24_DD_down
196	69	MA1979.1	ZNF416	MA1979.1	TATCTGGGCAH	ZNF416	0.0109	3.85e-05	8040	76.5	11100	74.2	1.03	DNR_24_DD_down
197	7	MA0657.1	KLF13	MA0657.1	RTGMCACGCCCCTTTTTG	KLF13	0.0148	5.2e-05	579	5.51	654	4.36	1.26	DNR_24_DD_down
198	70	MA1651.1	ZFP42	MA1651.1	NNNHCAARATGGCTGCCNBNN	ZFP42	0.0172	5.99e-05	254	2.42	251	1.68	1.44	DNR_24_DD_down
199	37	MA0056.2	MZF1	MA0056.2	NNAATCCCCANNN	MZF1	0.0224	7.76e-05	8190	77.9	11300	75.7	1.03	DNR_24_DD_down
200	20	MA1100.2	ASCL1	MA1100.2	VGCAGCTGCN	ASCL1	0.0234	8.07e-05	5380	51.2	7290	48.6	1.05	DNR_24_DD_down
201	49	MA1602.1	ZSCAN29	MA1602.1	YGTCTACRCNGN	ZSCAN29	0.0247	8.5e-05	2230	21.2	2880	19.2	1.11	DNR_24_DD_down
202	56	MA0862.1	GMEB2	MA0862.1	TTACGTAA	GMEB2	0.0314	0.000107	907	8.63	1090	7.26	1.19	DNR_24_DD_down
203	71	MA0737.1	GLIS3	MA0737.1	GACCCCCCACGAAG	GLIS3	0.0378	0.000128	690	6.56	806	5.38	1.22	DNR_24_DD_down
204	34	MA0500.2	MYOG	MA0500.2	NDRCAGCTGYHN	MYOG	0.0416	0.000141	6820	64.9	9370	62.5	1.04	DNR_24_DD_down
205	45	MA1575.1	THRB	MA1575.1	DTGACCTBRNYVAGGTCAH	THRB	0.0454	0.000153	616	5.86	712	4.75	1.23	DNR_24_DD_down
11	72	MA1981.1 (ZNF530)	STREME-10	10-GCCCTCCCCTTCC	10-GCCCTCCCCTTCC	ZNF530	0.0735	0.00668	30	0.29	20	0.13	2.1	DNR_24_DD_down
12	73	MA1107.2 (KLF9)	STREME-11	11-CCCCAACACCCAC	11-CCCCAACACCCAC	KLF9	0.294	0.0245	2690	25.6	3660	24.4	1.05	DNR_24_DD_down
13	74	MA1125.1 (ZNF384)	MEME-2	TTTTTTTTTTTTTTT	TTTTTTTTTTTTTTT	ZNF384	11.8	0.906	2	0.02	6	0.04	0.611	DNR_24_DD_down

ER_rat <- 1.25

DNR_24_DD_down_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DNR_24_DD_down_combo response peaks(200bp)Enrichment ratio:",ER_rat))

DNR_24_DD_down_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*2), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./2,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("DNR_24_DD_down_combo response peaks(200bp)Enrichment ratio:",ER_rat))

MTX

MTX 24_up hour

MTX_24_DD_up_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_DEG_24_up_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
MTX_24_DD_up_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_DEG_24_up_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
MTX_24_DD_up_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_DEG_24_up_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
MTX_24_DD_up_sea_all <- rbind(MTX_24_DD_up_sea_disc, MTX_24_DD_up_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

MTX_24_DD_up_combo <- MTX_24_DD_up_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., MTX_24_DD_up_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="MTX_24_DD_up")

MTX_24_DD_up_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "MTX_24_DD_up MTX enriched motifs") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

MTX_24_DD_up MTX enriched motifs
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA0508.3 (PRDM1)	MEME-7	GSHGASAGAGRRAGR	GSHGASAGAGRRAGR	PRDM1	0.00656	0.0025	50	10.9	472	5.49	2.02	MTX_24_DD_up
2	2	MA0597.2 (THAP1)	STREME-1	1-GGCAGGCCACCC	GGCAGGCCACCC	THAP1	0.00699	0.0025	11	2.4	33	0.38	6.62	MTX_24_DD_up
3	3	MA1723.1 (PRDM9)	MEME-5	CCCMYCCCWSCCCMS	CCCMYCCCWSCCCMS	PRDM9	0.00754	0.0025	40	8.73	343	3.99	2.23	MTX_24_DD_up
4	4	MA1125.1 (ZNF384)	MEME-4	AAWAAAAAWAMAAAA	AAWAAAAAWAMAAAA	ZNF384	0.0193	0.0048	50	10.9	493	5.73	1.94	MTX_24_DD_up
5	5	MA0035.4 (GATA1)	STREME-2	2-AAGATTAGRAAGKCT	AAGATTAGRAAGKCT	GATA1	0.0304	0.00608	8	1.75	40	0.46	4.12	MTX_24_DD_up
6	6	3-CATGCGCCAS	STREME-3	3-CATGCGCCAS	CATGCGCCAS	CATGCGCCAS	0.075	0.0125	9	1.97	58	0.67	3.18	MTX_24_DD_up
7	7	GGCTGGAGTGCAGTG	MEME-6	GGCTGGAGTGCAGTG	GGCTGGAGTGCAGTG	GGCTGGAGTGCAGTG	0.346	0.0494	14	3.06	144	1.67	1.94	MTX_24_DD_up
8	8	MA0728.1 (Nr2F6)	MEME-8	GAGSCCAGGAG	GAGSCCAGGAG	Nr2F6	0.817	0.102	3	0.66	16	0.19	4.41	MTX_24_DD_up
9	9	MA0483.1 (Gfi1B)	MEME-9	YCTGTARTCCCAGCW	YCTGTARTCCCAGCW	Gfi1B	2.04	0.227	25	5.46	379	4.4	1.28	MTX_24_DD_up
10	10	MA1134.1 (FOS::JUNB)	MEME-1	DRTGASTCAKV	DRTGASTCAKV	FOS::JUNB	2.47	0.247	45	9.83	741	8.61	1.16	MTX_24_DD_up
11	11	MA1107.2 (KLF9)	MEME-3	TGTGTGYRTGTGTG	TGTGTGYRTGTGTG	KLF9	2.76	0.251	41	8.95	679	7.89	1.16	MTX_24_DD_up
12	11	GTGTRTGTGTGTGTG	MEME-2	GTGTRTGTGTGTGTG	GTGTRTGTGTGTGTG	GTGTRTGTGTGTGTG	5.29	0.441	5	1.09	81	0.94	1.37	MTX_24_DD_up

ER_rat <- 1.25

MTX_24_DD_up_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("MTX_24_DD_up_combo response peaks(200bp)Enrichment ratio:",ER_rat))

MTX_24_DD_up_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*.2), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.2,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("MTX_24_DD_up_combo response peaks(200bp)Enrichment ratio:",ER_rat))

MTX 24_down hour

MTX_24_DD_down_sea_disc <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_DEG_24_down_xstreme/sea_disc_out/sea.tsv") %>% mutate(source="disc") %>% slice_head(n = length(.$ID)-3)
MTX_24_DD_down_sea_known <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_DEG_24_down_xstreme/sea_out/sea.tsv") %>% mutate(source="known") %>% slice_head(n = length(.$ID)-3)
MTX_24_DD_down_xstreme <- read.delim("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/MTX_DEG_24_down_xstreme/xstreme.tsv") %>% slice_head(n = length(.$ID)-3)
MTX_24_DD_down_sea_all <- rbind(MTX_24_DD_down_sea_disc, MTX_24_DD_down_sea_known) %>% 
  arrange(ID, desc(source == "known")) %>%  
  distinct(ID, .keep_all = TRUE)

MTX_24_DD_down_combo <- MTX_24_DD_down_xstreme %>% 
  dplyr::select(SEED_MOTIF:EVALUE_ACC,SIM_MOTIF) %>% 
  left_join(., MTX_24_DD_down_sea_all, by=c("ID"="ID","ALT_ID"="ALT_ID")) %>% 
  mutate(motif_name=case_when(
    str_detect(SIM_MOTIF, "\\(") ~ str_extract(SIM_MOTIF, "(?<=\\().+?(?=\\))"),
    str_detect(SIM_MOTIF, "^MA\\d+\\.\\d+") ~ ALT_ID,
    str_detect(SIM_MOTIF, "^\\d+-") ~ str_replace(SIM_MOTIF, "^\\d+-", ""),
  TRUE ~ SIM_MOTIF
)) %>% 
  dplyr::select(RANK,CLUSTER,SIM_MOTIF,ALT_ID, ID,CONSENSUS.x,motif_name,EVALUE.y,QVALUE,TP:ENR_RATIO) %>% 
  arrange(.,EVALUE.y) %>% 
  mutate(mrc_type="MTX_24_DD_down")

MTX_24_DD_down_combo %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "MTX_24_DD_down MTX enriched motifs") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

MTX_24_DD_down MTX enriched motifs
RANK	CLUSTER	SIM_MOTIF	ALT_ID	ID	CONSENSUS.x	motif_name	EVALUE.y	QVALUE	TP	TP.	FP	FP.	ENR_RATIO	mrc_type
1	1	MA0742.2 (KLF12)	STREME-3	3-CYCGCCMCMG	CYCGCCMCMG	KLF12	2.94e-11	2.45e-11	397	45.7	1510	32.3	1.42	MTX_24_DD_down
2	2	MA0527.1	ZBTB33	MA0527.1	BTCTCGCGAGABYTS	ZBTB33	2.08e-10	8.67e-11	223	25.7	709	15.2	1.7	MTX_24_DD_down
3	3	MA0864.2	E2F2	MA0864.2	RWTTTGGCGCCAWWWY	E2F2	9.97e-10	2.77e-10	123	14.2	309	6.6	2.15	MTX_24_DD_down
4	4	MA1513.1	KLF15	MA1513.1	SCCCCGCCCCS	KLF15	5.24e-08	1.09e-08	182	20.9	576	12.3	1.71	MTX_24_DD_down
5	5	MA0823.1	HEY1	MA0823.1	GRCACGTGCC	HEY1	8.74e-08	1.46e-08	437	50.3	1810	38.6	1.3	MTX_24_DD_down
6	4	MA1515.1	KLF2	MA1515.1	NRCCACRCCCH	KLF2	1.48e-07	2.05e-08	392	45.1	1580	33.8	1.34	MTX_24_DD_down
7	6	MA0733.1	EGR4	MA0733.1	NHMCGCCCACGCAHWT	EGR4	3.67e-07	4.13e-08	527	60.6	2310	49.3	1.23	MTX_24_DD_down
8	5	MA1106.1	HIF1A	MA1106.1	SBACGTGCNN	HIF1A	3.97e-07	4.13e-08	516	59.4	2250	48	1.24	MTX_24_DD_down
9	5	MA0649.1	HEY2	MA0649.1	GRCACGTGYC	HEY2	1e-06	9.27e-08	181	20.8	597	12.8	1.64	MTX_24_DD_down
10	6	MA0162.4	EGR1	MA0162.4	VCMCGCCCACGCVS	EGR1	1.76e-06	1.47e-07	466	53.6	2000	42.7	1.26	MTX_24_DD_down
11	4	MA0685.2	SP4	MA0685.2	GGGGCGGGG	SP4	2.1e-06	1.55e-07	344	39.6	1370	29.4	1.35	MTX_24_DD_down
12	7	4-GSGCGCTGC	STREME-4	4-GSGCGCTGC	GSGCGCTGC	GSGCGCTGC	2.23e-06	1.55e-07	64	7.36	135	2.88	2.57	MTX_24_DD_down
13	4	MA0742.2	KLF12	MA0742.2	GGGGCGGGG	KLF12	3.39e-06	2.17e-07	501	57.6	2200	46.9	1.23	MTX_24_DD_down
14	5	MA0632.2	TCFL5	MA0632.2	KCACGCGCMC	TCFL5	4.34e-06	2.58e-07	134	15.4	408	8.72	1.78	MTX_24_DD_down
15	4	MA1522.1	MAZ	MA1522.1	BBCCCCTCCCY	MAZ	4.82e-06	2.68e-07	305	35.1	1190	25.5	1.38	MTX_24_DD_down
16	8	MA1122.1	TFDP1	MA1122.1	VSGCGGGAAVN	TFDP1	6.69e-06	3.48e-07	137	15.8	424	9.06	1.75	MTX_24_DD_down
17	4	MA1511.2	KLF10	MA1511.2	GGGGCGGGG	KLF10	8.53e-06	4.18e-07	484	55.7	2120	45.3	1.23	MTX_24_DD_down
18	4	MA1961.1	PATZ1	MA1961.1	SSGGGGMGGGGS	PATZ1	2.15e-05	9.93e-07	247	28.4	931	19.9	1.43	MTX_24_DD_down
19	9	MA0736.1	GLIS2	MA0736.1	GACCCCCCGCRAMG	GLIS2	6.01e-05	2.63e-06	264	30.4	1020	21.9	1.39	MTX_24_DD_down
20	4	MA0753.2	ZNF740	MA0753.2	CYRCCCCCCCCAC	ZNF740	0.000109	4.55e-06	284	32.7	1130	24.2	1.36	MTX_24_DD_down
21	4	MA0079.5	SP1	MA0079.5	GGGGCGGGG	SP1	0.000117	4.62e-06	283	32.6	1130	24.1	1.36	MTX_24_DD_down
22	10	MA1514.1	KLF17	MA1514.1	MMCCACGCACCCMTY	KLF17	0.00017	5.96e-06	390	44.9	1670	35.7	1.26	MTX_24_DD_down
23	11	MA1712.1	ZNF454	MA1712.1	DGGCTCSSGGCCCYGVKG	ZNF454	0.000171	5.96e-06	137	15.8	452	9.66	1.64	MTX_24_DD_down
24	8	MA1583.1	ZFP57	MA1583.1	NNVTTGCCGCANN	ZFP57	0.000178	5.96e-06	314	36.1	1280	27.5	1.32	MTX_24_DD_down
25	12	MA0146.2	Zfx	MA0146.2	SSSGCCBVGGCCTS	Zfx	0.000179	5.96e-06	397	45.7	1710	36.5	1.25	MTX_24_DD_down
26	4	MA1653.1	ZNF148	MA1653.1	YBCCCCTCCCCC	ZNF148	0.000212	6.59e-06	451	51.9	1990	42.6	1.22	MTX_24_DD_down
27	4	MA1965.1	SP5	MA1965.1	CBCCTCCCHS	SP5	0.000214	6.59e-06	398	45.8	1720	36.6	1.25	MTX_24_DD_down
28	5	MA1464.1	ARNT2	MA1464.1	GTCACGTGMN	ARNT2	0.00024	7.12e-06	234	26.9	899	19.2	1.4	MTX_24_DD_down
29	13	MA1929.1	CTCF	MA1929.1	CTGCAGTKCCNNNNNYNRCCASYAGRKGGCRSWG	CTCF	0.000253	7.28e-06	135	15.5	447	9.55	1.63	MTX_24_DD_down
30	5	MA0104.4	MYCN	MA0104.4	VVCCACGTGGBB	MYCN	0.000356	9.89e-06	69	7.94	179	3.82	2.09	MTX_24_DD_down
31	14	MA1596.1	ZNF460	MA1596.1	GCCTCMGCCTCCCRAG	ZNF460	0.000448	1.17e-05	171	19.7	613	13.1	1.51	MTX_24_DD_down
32	5	MA1099.2	HES1	MA1099.2	GGCRCGTGBC	HES1	0.00045	1.17e-05	94	10.8	279	5.96	1.83	MTX_24_DD_down
33	4	MA0741.1	KLF16	MA0741.1	GMCACGCCCCC	KLF16	0.000483	1.22e-05	521	60	2380	50.9	1.18	MTX_24_DD_down
34	4	MA1512.1	KLF11	MA1512.1	SCCACGCCCMC	KLF11	0.000505	1.24e-05	268	30.8	1070	22.9	1.35	MTX_24_DD_down
35	5	MA0616.2	HES2	MA0616.2	GGCACGTGYC	HES2	0.00054	1.29e-05	106	12.2	330	7.05	1.74	MTX_24_DD_down
36	9	MA0751.1	ZIC4	MA0751.1	GRCCCCCCGCKGYGH	ZIC4	0.00058	1.34e-05	650	74.8	3110	66.5	1.12	MTX_24_DD_down
37	15	MA0750.2	ZBTB7A	MA0750.2	NVCCGGAAGTGSV	ZBTB7A	0.00075	1.69e-05	274	31.5	1110	23.7	1.33	MTX_24_DD_down
38	4	MA0493.2	KLF1	MA0493.2	DGGGYGGGG	KLF1	0.000869	1.9e-05	554	63.8	2580	55	1.16	MTX_24_DD_down
39	4	MA0516.3	SP2	MA0516.3	GGGGCGGGG	SP2	0.00102	2.17e-05	385	44.3	1670	35.8	1.24	MTX_24_DD_down
40	16	MA1147.1	NR4A2::RXRA	MA1147.1	VRGGTCRTTGACCYY	NR4A2::RXRA	0.00109	2.26e-05	527	60.6	2430	51.9	1.17	MTX_24_DD_down
41	3	MA0865.2	E2F8	MA0865.2	TTCCCGCCAHWA	E2F8	0.00117	2.37e-05	108	12.4	345	7.37	1.7	MTX_24_DD_down
42	17	MA1721.1	ZNF93	MA1721.1	GGYAGCRGCAGCGGYG	ZNF93	0.00152	3.02e-05	491	56.5	2240	47.9	1.18	MTX_24_DD_down
43	18	MA1986.1	ZNF692	MA1986.1	BGGGCCCASN	ZNF692	0.00156	3.02e-05	469	54	2120	45.4	1.19	MTX_24_DD_down
44	13	MA1102.2	CTCFL	MA1102.2	NSCAGGGGGCGS	CTCFL	0.00167	3.14e-05	111	12.8	361	7.71	1.66	MTX_24_DD_down
3	21	2-CGCGTCGS	STREME-2	2-CGCGTCGS	CGCGTCGS	CGCGTCGS	0.00167	0.000556	18	2.07	32	0.68	3.1	MTX_24_DD_down
45	6	MA1627.1	Wt1	MA1627.1	YBCCTCCCCCACVB	Wt1	0.0017	3.14e-05	305	35.1	1270	27.2	1.29	MTX_24_DD_down
46	5	MA1474.1	CREB3L4	MA1474.1	YGCCACGTCAYC	CREB3L4	0.002	3.62e-05	356	41	1540	32.8	1.25	MTX_24_DD_down
47	4	MA1517.1	KLF6	MA1517.1	NRCCACGCCCH	KLF6	0.00219	3.88e-05	300	34.5	1250	26.8	1.29	MTX_24_DD_down
48	5	MA1560.1	SOHLH2	MA1560.1	YGCACGTGCN	SOHLH2	0.00235	4.07e-05	378	43.5	1650	35.3	1.23	MTX_24_DD_down
49	4	MA1516.1	KLF3	MA1516.1	GRCCRCGCCCH	KLF3	0.00334	5.68e-05	559	64.3	2630	56.2	1.15	MTX_24_DD_down
50	4	MA1564.1	SP9	MA1564.1	RCCACGCCCMCY	SP9	0.00352	5.87e-05	231	26.6	921	19.7	1.35	MTX_24_DD_down
51	4	MA1959.1	KLF7	MA1959.1	DGGGCGGGG	KLF7	0.00376	6.14e-05	534	61.4	2490	53.2	1.15	MTX_24_DD_down
52	4	MA0740.2	KLF14	MA0740.2	KGGGCGGGG	KLF14	0.00478	7.65e-05	539	62	2520	53.9	1.15	MTX_24_DD_down
53	4	MA1630.2	ZNF281	MA1630.2	GGGGGAGGGGVV	ZNF281	0.00499	7.84e-05	255	29.3	1040	22.3	1.32	MTX_24_DD_down
54	13	MA1976.1	ZNF320	MA1976.1	DGKGGGRCCMRGGGGCCWGTGHVNNNN	ZNF320	0.00586	9.04e-05	178	20.5	676	14.4	1.42	MTX_24_DD_down
55	5	MA1941.1	ETV2::FIGLA	MA1941.1	RSCGGAARCAGSTGBN	ETV2::FIGLA	0.00724	0.00011	592	68.1	2830	60.4	1.13	MTX_24_DD_down
56	6	MA0506.2	Nrf1	MA0506.2	SNCTGCGCMTGCGCV	Nrf1	0.00779	0.000116	122	14	424	9.06	1.56	MTX_24_DD_down
57	6	MA0472.2	EGR2	MA0472.2	MCGCCCACGCA	EGR2	0.00963	0.000141	128	14.7	453	9.68	1.53	MTX_24_DD_down
58	4	MA1713.1	ZNF610	MA1713.1	SSCGCCGCTCCSSS	ZNF610	0.0127	0.000183	68	7.83	199	4.25	1.86	MTX_24_DD_down
59	19	MA0524.2	TFAP2C	MA0524.2	YGCCYBVRGGCA	TFAP2C	0.0135	0.000189	83	9.55	261	5.58	1.73	MTX_24_DD_down
60	15	MA0814.2	TFAP2C	MA0814.2	NNGCCTGAGGCGNN	TFAP2C	0.0136	0.000189	425	48.9	1930	41.2	1.19	MTX_24_DD_down
4	22	1-CCCGGCGG	STREME-1	1-CCCGGCGG	CCCGGCGG	CCCGGCGG	0.0138	0.00345	38	4.37	118	2.52	1.76	MTX_24_DD_down
61	5	MA0522.3	TCF3	MA0522.3	NVCACCTGCNN	TCF3	0.018	0.000246	736	84.7	3680	78.7	1.08	MTX_24_DD_down
62	9	MA0696.1	ZIC1	MA0696.1	GACCCCCYGCTGTG	ZIC1	0.0198	0.000266	241	27.7	996	21.3	1.31	MTX_24_DD_down
63	5	MA0147.3	MYC	MA0147.3	NNCCACGTGCNB	MYC	0.0203	0.000267	197	22.7	783	16.7	1.36	MTX_24_DD_down
64	3	MA0470.2	E2F4	MA0470.2	TTTTGGCGCCAWWW	E2F4	0.0205	0.000267	32	3.68	67	1.43	2.61	MTX_24_DD_down
65	20	MA1981.1	ZNF530	MA1981.1	GMARGGMRAGGGGCRGSV	ZNF530	0.03	0.000384	516	59.4	2430	52	1.14	MTX_24_DD_down
66	3	MA0748.2	YY2	MA0748.2	NVATGGCGGCS	YY2	0.0386	0.000487	577	66.4	2780	59.3	1.12	MTX_24_DD_down
5	23	MA1125.1 (ZNF384)	MEME-1	AAAAAAAAAAAARAA	AAAAAAAAAAAARAA	ZNF384	0.0429	0.00858	23	2.65	66	1.41	1.93	MTX_24_DD_down

ER_rat <- 1.25

MTX_24_DD_down_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
  slice_head(n=80)%>% 
  mutate(log10Evalue= log(EVALUE.y, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("MTX_24_DD_down_combo response peaks(200bp)Enrichment ratio:",ER_rat))

MTX_24_DD_down_combo %>% 
   dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER,motif_name,SIM_MOTIF,ALT_ID, ID,EVALUE.y,TP.)%>%
  arrange(.,EVALUE.y) %>%
    mutate(log10Evalue = -log10(if_else(EVALUE.y == 0, 1e-300, EVALUE.y))) %>% 
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  mutate(motif_name=if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="KLF9",paste(motif_name, RANK,sep="_"),motif_name)))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue)) +
  geom_point(aes(x=`TP.`*.2), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./.2,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste("MTX_24_DD_down_combo response peaks(200bp)Enrichment ratio:",ER_rat))

other things

meme_motifs_EAR_open <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_open_xstreme/xstreme.txt")
meme_motifs_ESR_open <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_open_xstreme/xstreme.txt")
meme_motifs_LR_open <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_open_xstreme/xstreme.txt")
meme_motifs_EAR_close <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/EAR_close_xstreme/xstreme.txt")
meme_motifs_ESR_close <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_close_xstreme/xstreme.txt")
meme_motifs_LR_close <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/LR_close_xstreme/xstreme.txt")
meme_motifs_ESR_opcl <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_opcl_xstreme/xstreme.txt")
meme_motifs_ESR_clop <- read_meme("C:/Users/renee/ATAC_folder/ATAC_meme_data/new_analysis/ESR_clop_xstreme/xstreme.txt")

Looking at combo tables

DRUG_24_DD_df <- bind_rows(DOX_24_DD_up_combo,
          DOX_24_DD_down_combo,
          )

DRUG_24_DD_df %>% 
  dplyr::select(CLUSTER:EVALUE.y, ENR_RATIO,mrc_type) %>%  
  dplyr::filter(ENR_RATIO>1.25) %>% 
 # dplyr::filter(EVALUE.y<0.05) %>%  
  group_by(mrc_type,CLUSTER) %>% 
  summarize(ID=paste(unique(ID), collapse = ";"),
            ALT_ID=paste(unique(ALT_ID), collapse = ";"),
            motif_name=paste(unique(motif_name),collapse="; "),
            # mrc=unique(mrc_type),
            sig_val=paste0(min(EVALUE.y),"-",max(EVALUE.y)),
            order_val=min(EVALUE.y)) %>% 
    arrange(mrc_type,order_val) %>% 
    DT::datatable(.)

sessionInfo()

R version 4.4.2 (2024-10-31 ucrt)
Platform: x86_64-w64-mingw32/x64
Running under: Windows 11 x64 (build 26100)

Matrix products: default


locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

time zone: America/Chicago
tzcode source: internal

attached base packages:
[1] grid      stats4    stats     graphics  grDevices utils     datasets 
[8] methods   base     

other attached packages:
 [1] ggseqlogo_0.2                           
 [2] universalmotif_1.24.2                   
 [3] data.table_1.17.6                       
 [4] BSgenome.Hsapiens.UCSC.hg38_1.4.5       
 [5] BSgenome_1.74.0                         
 [6] BiocIO_1.16.0                           
 [7] MotifDb_1.48.0                          
 [8] Biostrings_2.74.1                       
 [9] XVector_0.46.0                          
[10] JASPAR2022_0.99.8                       
[11] BiocFileCache_2.14.0                    
[12] dbplyr_2.5.0                            
[13] devtools_2.4.5                          
[14] usethis_3.1.0                           
[15] ggpubr_0.6.1                            
[16] BiocParallel_1.40.2                     
[17] Cormotif_1.52.0                         
[18] affy_1.84.0                             
[19] scales_1.4.0                            
[20] VennDiagram_1.7.3                       
[21] futile.logger_1.4.3                     
[22] gridExtra_2.3                           
[23] ggfortify_0.4.18                        
[24] edgeR_4.4.2                             
[25] limma_3.62.2                            
[26] rtracklayer_1.66.0                      
[27] org.Hs.eg.db_3.20.0                     
[28] TxDb.Hsapiens.UCSC.hg38.knownGene_3.20.0
[29] GenomicFeatures_1.58.0                  
[30] AnnotationDbi_1.68.0                    
[31] Biobase_2.66.0                          
[32] GenomicRanges_1.58.0                    
[33] GenomeInfoDb_1.42.3                     
[34] IRanges_2.40.1                          
[35] S4Vectors_0.44.0                        
[36] BiocGenerics_0.52.0                     
[37] ChIPseeker_1.42.1                       
[38] RColorBrewer_1.1-3                      
[39] broom_1.0.8                             
[40] kableExtra_1.4.0                        
[41] cowplot_1.1.3                           
[42] lubridate_1.9.4                         
[43] forcats_1.0.0                           
[44] stringr_1.5.1                           
[45] dplyr_1.1.4                             
[46] purrr_1.0.4                             
[47] readr_2.1.5                             
[48] tidyr_1.3.1                             
[49] tibble_3.3.0                            
[50] ggplot2_3.5.2                           
[51] tidyverse_2.0.0                         
[52] workflowr_1.7.1                         

loaded via a namespace (and not attached):
  [1] fs_1.6.6                               
  [2] matrixStats_1.5.0                      
  [3] bitops_1.0-9                           
  [4] enrichplot_1.26.6                      
  [5] httr_1.4.7                             
  [6] profvis_0.4.0                          
  [7] tools_4.4.2                            
  [8] backports_1.5.0                        
  [9] DT_0.33                                
 [10] R6_2.6.1                               
 [11] lazyeval_0.2.2                         
 [12] urlchecker_1.0.1                       
 [13] withr_3.0.2                            
 [14] preprocessCore_1.68.0                  
 [15] cli_3.6.5                              
 [16] textshaping_1.0.1                      
 [17] formatR_1.14                           
 [18] labeling_0.4.3                         
 [19] sass_0.4.10                            
 [20] Rsamtools_2.22.0                       
 [21] systemfonts_1.2.3                      
 [22] yulab.utils_0.2.0                      
 [23] DOSE_4.0.1                             
 [24] svglite_2.2.1                          
 [25] R.utils_2.13.0                         
 [26] dichromat_2.0-0.1                      
 [27] sessioninfo_1.2.3                      
 [28] plotrix_3.8-4                          
 [29] rstudioapi_0.17.1                      
 [30] RSQLite_2.4.1                          
 [31] generics_0.1.4                         
 [32] gridGraphics_0.5-1                     
 [33] TxDb.Hsapiens.UCSC.hg19.knownGene_3.2.2
 [34] crosstalk_1.2.1                        
 [35] gtools_3.9.5                           
 [36] car_3.1-3                              
 [37] GO.db_3.20.0                           
 [38] Matrix_1.7-3                           
 [39] abind_1.4-8                            
 [40] R.methodsS3_1.8.2                      
 [41] lifecycle_1.0.4                        
 [42] whisker_0.4.1                          
 [43] yaml_2.3.10                            
 [44] carData_3.0-5                          
 [45] SummarizedExperiment_1.36.0            
 [46] gplots_3.2.0                           
 [47] qvalue_2.38.0                          
 [48] SparseArray_1.6.2                      
 [49] blob_1.2.4                             
 [50] promises_1.3.3                         
 [51] crayon_1.5.3                           
 [52] miniUI_0.1.2                           
 [53] ggtangle_0.0.7                         
 [54] lattice_0.22-7                         
 [55] KEGGREST_1.46.0                        
 [56] pillar_1.11.0                          
 [57] knitr_1.50                             
 [58] fgsea_1.32.4                           
 [59] rjson_0.2.23                           
 [60] boot_1.3-31                            
 [61] codetools_0.2-20                       
 [62] fastmatch_1.1-6                        
 [63] glue_1.8.0                             
 [64] getPass_0.2-4                          
 [65] ggfun_0.1.9                            
 [66] remotes_2.5.0                          
 [67] vctrs_0.6.5                            
 [68] png_0.1-8                              
 [69] treeio_1.30.0                          
 [70] gtable_0.3.6                           
 [71] cachem_1.1.0                           
 [72] xfun_0.52                              
 [73] S4Arrays_1.6.0                         
 [74] mime_0.13                              
 [75] statmod_1.5.0                          
 [76] ellipsis_0.3.2                         
 [77] nlme_3.1-168                           
 [78] ggtree_3.14.0                          
 [79] bit64_4.6.0-1                          
 [80] filelock_1.0.3                         
 [81] rprojroot_2.0.4                        
 [82] bslib_0.9.0                            
 [83] affyio_1.76.0                          
 [84] KernSmooth_2.23-26                     
 [85] splitstackshape_1.4.8                  
 [86] colorspace_2.1-1                       
 [87] DBI_1.2.3                              
 [88] tidyselect_1.2.1                       
 [89] processx_3.8.6                         
 [90] bit_4.6.0                              
 [91] compiler_4.4.2                         
 [92] curl_6.4.0                             
 [93] git2r_0.36.2                           
 [94] xml2_1.3.8                             
 [95] DelayedArray_0.32.0                    
 [96] caTools_1.18.3                         
 [97] callr_3.7.6                            
 [98] digest_0.6.37                          
 [99] rmarkdown_2.29                         
[100] htmltools_0.5.8.1                      
[101] pkgconfig_2.0.3                        
[102] MatrixGenerics_1.18.1                  
[103] fastmap_1.2.0                          
[104] rlang_1.1.6                            
[105] htmlwidgets_1.6.4                      
[106] UCSC.utils_1.2.0                       
[107] shiny_1.11.1                           
[108] farver_2.1.2                           
[109] jquerylib_0.1.4                        
[110] jsonlite_2.0.0                         
[111] GOSemSim_2.32.0                        
[112] R.oo_1.27.1                            
[113] RCurl_1.98-1.17                        
[114] magrittr_2.0.3                         
[115] Formula_1.2-5                          
[116] GenomeInfoDbData_1.2.13                
[117] ggplotify_0.1.2                        
[118] patchwork_1.3.1                        
[119] Rcpp_1.1.0                             
[120] ape_5.8-1                              
[121] stringi_1.8.7                          
[122] MASS_7.3-65                            
[123] zlibbioc_1.52.0                        
[124] plyr_1.8.9                             
[125] pkgbuild_1.4.8                         
[126] parallel_4.4.2                         
[127] ggrepel_0.9.6                          
[128] splines_4.4.2                          
[129] hms_1.1.3                              
[130] locfit_1.5-9.12                        
[131] ps_1.9.1                               
[132] igraph_2.1.4                           
[133] ggsignif_0.6.4                         
[134] reshape2_1.4.4                         
[135] pkgload_1.4.0                          
[136] futile.options_1.0.1                   
[137] XML_3.99-0.18                          
[138] evaluate_1.0.4                         
[139] lambda.r_1.2.4                         
[140] BiocManager_1.30.26                    
[141] tzdb_0.5.0                             
[142] httpuv_1.6.16                          
[143] xtable_1.8-4                           
[144] restfulr_0.0.16                        
[145] tidytree_0.4.6                         
[146] rstatix_0.7.2                          
[147] later_1.4.2                            
[148] viridisLite_0.4.2                      
[149] aplot_0.2.8                            
[150] memoise_2.0.1                          
[151] GenomicAlignments_1.42.0               
[152] timechange_0.3.0

Jaspar_motif_DAR

Renee Matthews

2025-06-16

DOX