Jaspar_enrichment

Last updated: 2024-10-09

Checks: 7 0

Knit directory: ATAC_learning/

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Repository version: 12a7203

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Untracked files:
    Untracked:  Correlationplot_scaled.pdf
    Untracked:  DOX_DAR_assess.Rmd
    Untracked:  EAR_2_plot.pdf
    Untracked:  ESR_1_plot.pdf
    Untracked:  Firstcorr plotATAC.pdf
    Untracked:  IND1_2_3_6_corrplot.pdf
    Untracked:  LR_3_plot.pdf
    Untracked:  NR_1_plot.pdf
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    Untracked:  analysis/my_hc_filt_counts.csv
    Untracked:  analysis/nucleosome_explore.Rmd
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    Untracked:  trimmed_Ind1_75DA24h_S7.nodup.fragment.size.distribution.pdf
    Untracked:  trimmed_Ind1_75DA3h_S1.nodup.fragment.size.distribution.pdf

Unstaged changes:
    Modified:   analysis/CorMotif_data_n45.Rmd
    Modified:   analysis/Enhancer_files_ff.Rmd
    Modified:   analysis/Enrichment_motif.Rmd
    Modified:   analysis/Peak_calling.Rmd
    Modified:   analysis/Raodah.Rmd
    Modified:   analysis/Smaller_set_DAR.Rmd
    Modified:   analysis/TE_analysis.Rmd
    Modified:   analysis/TE_analysis_ff.Rmd
    Modified:   analysis/final_four_analysis.Rmd

Note that any generated files, e.g. HTML, png, CSS, etc., are not included in this status report because it is ok for generated content to have uncommitted changes.

These are the previous versions of the repository in which changes were made to the R Markdown (analysis/Jaspar_motif_ff.Rmd) and HTML (docs/Jaspar_motif_ff.html) files. If you’ve configured a remote Git repository (see ?wflow_git_remote), click on the hyperlinks in the table below to view the files as they were in that past version.

File	Version	Author	Date	Message
Rmd	12a7203	reneeisnowhere	2024-10-09	updates to motif position plots!
html	14551f7	reneeisnowhere	2024-09-26	Build site.
Rmd	6cdc685	reneeisnowhere	2024-09-26	updates with 4 sets of peaks

packages

library(tidyverse)
# library(ggsignif)
library(cowplot)
# library(ggpubr)

# library(sjmisc)
library(kableExtra)
library(broom)
# library(biomaRt)
library(RColorBrewer)
# library(gprofiler2)
# library(qvalue)
library(ChIPseeker)
library("TxDb.Hsapiens.UCSC.hg38.knownGene")
library("org.Hs.eg.db")
# library(ATACseqQC)
library(rtracklayer)
library(edgeR)
library(ggfortify)
library(limma)
library(readr)
library(BiocGenerics)
library(gridExtra)
library(VennDiagram)
library(scales)
# library(ggVennDiagram)
library(Cormotif)
library(BiocParallel)
library(ggpubr)
library(devtools)
# install_github('davetang/bedr')
# library(bedr)
library(JASPAR2022)
library(TFBSTools)
library(MotifDb)
library(BSgenome.Hsapiens.UCSC.hg38)
library(data.table)

Data loading

# 
# xstreme_ESR_clop200 <- read_delim("~/ATAC_meme_data/200bp/ESR_D_200xstreme/xstreme.tsv",
#     delim = "\t", escape_double = FALSE,
#     trim_ws = TRUE)

# saveRDS(xstreme_EAR_close200,"data/Final_four_data/xstreme/xstreme_EAR_close200.RDS")
# saveRDS(xstreme_EAR_open200,"data/Final_four_data/xstreme/xstreme_EAR_open200.RDS")
# saveRDS(xstreme_ESR_open200,"data/Final_four_data/xstreme/xstreme_ESR_open200.RDS")
# saveRDS(xstreme_ESR_close200,"data/Final_four_data/xstreme/xstreme_ESR_close200.RDS")
# saveRDS(ESR_OC_xstreme,"data/Final_four_data/xstreme/ESR_OC_xstreme.RDS")
# saveRDS(ESR_C_xstreme,"data/Final_four_data/xstreme/ESR_OC_xstreme.RDS")
# saveRDS(ESR_D_xstreme,"data/Final_four_data/xstreme/ESR_OC_xstreme.RDS")
# saveRDS(xstreme_LR_close200,"data/Final_four_data/xstreme/xstreme_LR_close200.RDS")
# saveRDS(xstreme_LR_open200,"data/Final_four_data/xstreme/xstreme_LR_open200.RDS")
# saveRDS(LR_open_10h_xstreme,"data/Final_four_data/xstreme/LR_open_10h_xstreme.RDS")
# saveRDS(xstreme_ESR_opcl200,"data/Final_four_data/xstreme/xstreme_ESR_opcl200.RDS")


EAR_close_xstreme <-
  readRDS("data/Final_four_data/xstreme/EAR_close_xstreme.RDS")%>%
  slice_head(n = length(.$ID)-3)
EAR_open_xstreme <- 
  readRDS("data/Final_four_data/xstreme/EAR_open_xstreme.RDS")%>%
  slice_head(n = length(.$ID)-3)
ESR_open_xstreme <- 
  readRDS("data/Final_four_data/xstreme/ESR_open_xstreme.RDS")%>%
  slice_head(n = length(.$ID)-3)
ESR_close_xstreme <- 
  readRDS("data/Final_four_data/xstreme/ESR_close_xstreme.RDS")%>%
  slice_head(n = length(.$ID)-3)
ESR_OC_xstreme <- 
  readRDS("data/Final_four_data/xstreme/ESR_OC_xstreme.RDS")%>%
  slice_head(n = length(.$ID)-3)
ESR_opcl_xstreme <- 
  readRDS("data/Final_four_data/xstreme/xstreme_ESR_opcl200.RDS")%>%
  slice_head(n = length(.$ID)-3)



LR_close_xstreme <-
  readRDS("data/Final_four_data/xstreme/LR_close_xstreme.RDS")%>%
  slice_head(n = length(.$ID)-3)
LR_open_xstreme <-
  readRDS("data/Final_four_data/xstreme/LR_open_10h_xstreme.RDS")%>%
  slice_head(n = length(.$ID)-3)
LR_open_10h_xstreme <-
  readRDS("data/Final_four_data/xstreme/LR_open_10h_xstreme.RDS")%>%
  slice_head(n = length(.$ID)-3)




EAR_close_200xstreme <-
  readRDS("data/Final_four_data/xstreme/xstreme_EAR_close200.RDS")%>%
  slice_head(n = length(.$ID)-3)
EAR_open_200xstreme <- 
  readRDS("data/Final_four_data/xstreme/xstreme_EAR_open200.RDS")%>%
  slice_head(n = length(.$ID)-3)
ESR_open_200xstreme <- 
  readRDS("data/Final_four_data/xstreme/xstreme_ESR_open200.RDS")%>%
  slice_head(n = length(.$ID)-3)

ESR_close_200xstreme <- 
  readRDS("data/Final_four_data/xstreme/xstreme_ESR_close200.RDS")%>%
  slice_head(n = length(.$ID)-3)
ESR_OC_xstreme <-
  readRDS("data/Final_four_data/xstreme/xstreme_LR_open200.RDS")%>%
  slice_head(n = length(.$ID)-3)
LR_close_200xstreme <-
  readRDS("data/Final_four_data/xstreme/xstreme_LR_close200.RDS")%>%
  slice_head(n = length(.$ID)-3)
LR_open_200xstreme <-
  readRDS("data/Final_four_data/xstreme/xstreme_LR_open200.RDS")%>%
  slice_head(n = length(.$ID)-3)
#### full sequence sea out
sea_EAR_open <- readRDS("data/Final_four_data/xstreme/sea_EAR_open.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_EAR_close <- readRDS("data/Final_four_data/xstreme/sea_EAR_close.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_ESR_close <- readRDS("data/Final_four_data/xstreme/sea_ESR_close.RDS")
sea_ESR_open <- readRDS("data/Final_four_data/xstreme/sea_ESR_open.RDS")#%>%
  # slice_head(n = length(.$ID)-3)
 
sea_ESR_OC <- readRDS("data/Final_four_data/xstreme/sea_ESR_OC.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_LR_open <- readRDS("data/Final_four_data/xstreme/sea_LR_open_10h.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_LR_close <- readRDS("data/Final_four_data/xstreme/sea_LR_close.RDS")%>%
  slice_head(n = length(.$ID)-3)

sea_LR_open <- readRDS("data/Final_four_data/xstreme/sea_LR_open_10h.RDS")%>%
  slice_head(n = length(.$ID)-3)


### sea out 200 bp sequences
# sea_ESR_opcl200 <- read_delim("~/ATAC_meme_data/200bp/ESR_C_200xstreme/sea_out/sea.tsv",
#     delim = "\t", escape_double = FALSE,
#     trim_ws = TRUE)
# saveRDS(sea_ESR_opcl200,"data/Final_four_data/xstreme/sea_ESR_opcl_200.RDS")

### sea part2!

sea_EAR_open_200 <- readRDS("data/Final_four_data/xstreme/sea_EAR_open_200.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_EAR_close_200 <- readRDS("data/Final_four_data/xstreme/sea_EAR_close_200.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_ESR_close_200 <- readRDS("data/Final_four_data/xstreme/sea_ESR_close_200.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_ESR_open_200 <- readRDS("data/Final_four_data/xstreme/sea_ESR_open_200.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_ESR_opcl_200 <- readRDS("data/Final_four_data/xstreme/sea_ESR_opcl_200.RDS")%>%
  slice_head(n = length(.$ID)-3)

sea_LR_open_200 <- readRDS("data/Final_four_data/xstreme/sea_LR_open_200.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_LR_close_200 <- readRDS("data/Final_four_data/xstreme/sea_LR_close_200.RDS")%>%
  slice_head(n = length(.$ID)-3)


### sea part2!  This is for missing merged data in sea_disc_out 
# sea_ESR_opcl_p2 <- read_delim("~/ATAC_meme_data/200bp/ESR_C_200xstreme/sea_disc_out/sea.tsv",
#     delim = "\t", escape_double = FALSE,
#     trim_ws = TRUE)
# saveRDS(sea_ESR_opcl_p2,"data/Final_four_data/xstreme/sea_ESR_opcl_200_p2.RDS")


sea_EAR_open_200_p2 <- readRDS("data/Final_four_data/xstreme/sea_EAR_open_200_p2.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_EAR_close_200_p2 <- readRDS("data/Final_four_data/xstreme/sea_EAR_close_200_p2.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_ESR_close_200_p2 <- readRDS("data/Final_four_data/xstreme/sea_ESR_close_200_p2.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_ESR_open_200_p2 <- readRDS("data/Final_four_data/xstreme/sea_ESR_open_200_p2.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_ESR_opcl_200_p2 <- readRDS("data/Final_four_data/xstreme/sea_ESR_opcl_200_p2.RDS")%>%
  slice_head(n = length(.$ID)-3)

sea_LR_open_200_p2 <- readRDS("data/Final_four_data/xstreme/sea_LR_open_200_p2.RDS")%>%
  slice_head(n = length(.$ID)-3)
sea_LR_close_200_p2 <- readRDS("data/Final_four_data/xstreme/sea_LR_close_200_p2.RDS")%>%
  slice_head(n = length(.$ID)-3)




peakAnnoList_ff_8motif <- readRDS("data/Final_four_data/peakAnnoList_ff_8motif.RDS")
# saveRDS(ESR_D,"data/Final_four_data/ESR_D.RDS") 
toplistall_RNA <- readRDS("data/other_papers/toplistall_RNA.RDS")
###Because of how I applied the DEG system in RNA-seq analysis, the lFC is opposite of the 
###counts.   I did trt-veh instead of veh-trt.  therefore I need to multiply lfc by -1 to get t
###the right correlation.

toplistall_RNA <- toplistall_RNA %>%
  mutate(logFC = logFC*(-1))

RNA_expresed_genes <- toplistall_RNA %>%
  # dplyr::filter(adj.P.Val <0.05) %>%
   mutate(expression = if_else(logFC<0,"down","up")) %>%
  dplyr::select(ENTREZID,SYMBOL,expression) %>%
  # dplyr::select(ENTREZID,SYMBOL) %>%
  unique(.)
RNA_expresed_genes_DE <- toplistall_RNA %>%
  dplyr::filter(adj.P.Val <0.05) %>%
  mutate(expression = if_else(logFC<0,"down","up")) %>%
  dplyr::select(ENTREZID,SYMBOL,expression) %>%
  unique(.)

Enrichment all peaks to NR peaks

EAR lists

EAR_open_xstreme%>% 
  dplyr::select(RANK,SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
  arrange(.,EVALUE) %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs in EAR open v NR
RANK	SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
2	MA0028.2	ELK1	MA0028.2	9.96e-21	8.47e-18
3	MA0759.2	ELK3	MA0759.2	3.63e-20	3.09e-17
6	MA0764.3	ETV4	MA0764.3	1.39e-17	1.18e-14
9	MA0765.3	ETV5	MA0765.3	3e-16	2.55e-13
11	MA0506.2	Nrf1	MA0506.2	1.8e-15	1.53e-12
12	MA1713.1	ZNF610	MA1713.1	1.57e-13	1.33e-10
13	MA0748.2	YY2	MA0748.2	4.05e-13	3.44e-10
16	MA1721.1	ZNF93	MA1721.1	8.74e-12	7.44e-09
17	MA1583.1	ZFP57	MA1583.1	9.6e-12	8.17e-09
18	MA1650.1	ZBTB14	MA1650.1	3.47e-11	2.96e-08
19	MA0645.1	ETV6	MA0645.1	5.29e-11	4.5e-08
20	MA1651.1	ZFP42	MA1651.1	2.24e-10	1.91e-07
22	MA0641.1	ELF4	MA0641.1	5.83e-09	4.96e-06
23	MA1484.1	ETS2	MA1484.1	9.13e-09	7.77e-06
24	MA1122.1	TFDP1	MA1122.1	1.08e-08	9.17e-06
25	MA0763.1	ETV3	MA0763.1	3.48e-08	2.96e-05
26	MA1931.1	ELK1::HOXA1	MA1931.1	4.49e-08	3.82e-05
27	MA1708.1	ETV7	MA1708.1	7.67e-08	6.52e-05
28	MA0156.3	FEV	MA0156.3	1.56e-07	0.000133
29	MA1483.2	ELF2	MA1483.2	1.84e-07	0.000157
30	MA0760.1	ERF	MA0760.1	3.21e-07	0.000273
31	MA0475.2	FLI1	MA0475.2	3.4e-07	0.000289
32	MA1711.1	ZNF343	MA1711.1	4.75e-07	0.000405
33	MA0632.2	TCFL5	MA0632.2	5.58e-07	0.000475
34	MA0024.3	E2F1	MA0024.3	8.18e-07	0.000696
35	MA0695.1	ZBTB7C	MA0695.1	1.22e-06	0.00104
36	MA0146.2	Zfx	MA0146.2	1.23e-06	0.00105
37	MA0527.1	ZBTB33	MA0527.1	1.26e-06	0.00107
38	MA0472.2	EGR2	MA0472.2	1.8e-06	0.00153
39	MA1933.1	ELK1::SREBF2	MA1933.1	2.38e-06	0.00203
40	MA0615.1	Gmeb1	MA0615.1	3.63e-06	0.00309
41	MA0750.2	ZBTB7A	MA0750.2	7.24e-06	0.00616
42	MA0098.3	ETS1	MA0098.3	8.15e-06	0.00694
14	MA0506.2 (Nrf1)	STREME-1	1-GCCGGCGCAGCC	3.9e-12	0.00744
43	MA0131.2	HINFP	MA0131.2	9.26e-06	0.00788
44	MA1727.1	ZNF417	MA1727.1	1.52e-05	0.0129
21	2-CGCTTCGHY	STREME-2	2-CGCTTCGHY	8.24e-10	0.0157
45	MA1569.1	TFAP2E	MA1569.1	1.87e-05	0.0159
46	MA0865.2	E2F8	MA0865.2	2.36e-05	0.0201
10	3-CGRGCCGCCK	STREME-3	3-CGRGCCGCCK	1.27e-15	0.0202
47	MA1684.1	Foxn1	MA1684.1	2.46e-05	0.0209
15	MA1721.1 (ZNF93)	STREME-4	4-CGGCGGCSGCGSC	6.87e-12	0.0228
48	MA1099.2	HES1	MA1099.2	2.77e-05	0.0236
49	MA0006.1	Ahr::Arnt	MA0006.1	3.19e-05	0.0272
7	5-CGGCCGGCGA	STREME-5	5-CGGCCGGCGA	2.2e-17	0.0274
50	MA1932.1	ELK1::HOXB13	MA1932.1	3.35e-05	0.0285
51	MA1513.1	KLF15	MA1513.1	3.47e-05	0.0295
8	6-CCGGCGCC	STREME-6	6-CCGGCGCC	7.53e-17	0.0332
4	MA0506.2 (Nrf1)	STREME-7	7-GCGSGCSCGC	2.08e-19	0.045
52	MA1107.2 (KLF9)	STREME-8	8-ACCACACACACACAA	0.00786	0.0638
5	9-CGCCGAACTC	STREME-9	9-CGCCGAACTC	4e-18	0.0643
1	MA0759.2 (ELK3)	STREME-10	10-CCGGAAGTGCY	1.49e-22	0.324

EAR_open_200xstreme%>% 
  dplyr::select(RANK,SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
  arrange(.,EVALUE) %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs 200 bp in EAR open v NR") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs 200 bp in EAR open v NR
RANK	SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
5	MA1650.1	ZBTB14	MA1650.1	2.42e-39	2.07e-36
7	MA0506.2	Nrf1	MA0506.2	2.82e-38	2.41e-35
114	MA1125.1 (ZNF384)	MEME-1	TTWTTTTTTTWTTTT	0.901	1.1e-31
9	MA1713.1	ZNF610	MA1713.1	2.55e-30	2.18e-27
12	MA0131.2	HINFP	MA0131.2	2.26e-24	1.93e-21
13	MA1122.1	TFDP1	MA1122.1	7.68e-24	6.56e-21
14	MA1721.1	ZNF93	MA1721.1	8.56e-24	7.31e-21
15	MA0865.2	E2F8	MA0865.2	1.39e-23	1.19e-20
16	MA1513.1	KLF15	MA1513.1	4.24e-23	3.62e-20
18	MA0024.3	E2F1	MA0024.3	3.59e-21	3.06e-18
19	MA0527.1	ZBTB33	MA0527.1	1.62e-19	1.38e-16
20	MA0162.4	EGR1	MA0162.4	1.45e-18	1.24e-15
21	MA0814.2	TFAP2C	MA0814.2	2.46e-18	2.1e-15
22	MA0748.2	YY2	MA0748.2	9.82e-18	8.38e-15
24	MA0632.2	TCFL5	MA0632.2	1.3e-16	1.11e-13
25	MA0864.2	E2F2	MA0864.2	2.29e-16	1.96e-13
26	MA0810.1	TFAP2A	MA0810.1	3.28e-16	2.8e-13
27	MA0823.1	HEY1	MA0823.1	6.39e-16	5.46e-13
28	MA0732.1	EGR3	MA0732.1	9.97e-16	8.51e-13
29	MA0470.2	E2F4	MA0470.2	2.35e-15	2.01e-12
30	MA0472.2	EGR2	MA0472.2	3.21e-15	2.74e-12
32	MA0759.2	ELK3	MA0759.2	9.84e-15	8.4e-12
33	MA1106.1	HIF1A	MA1106.1	5.52e-14	4.71e-11
34	MA0764.3	ETV4	MA0764.3	1.78e-13	1.52e-10
35	MA0028.2	ELK1	MA0028.2	1.96e-13	1.67e-10
36	MA0006.1	Ahr::Arnt	MA0006.1	2.04e-13	1.74e-10
37	MA0615.1	Gmeb1	MA0615.1	4.9e-13	4.18e-10
38	MA0524.2	TFAP2C	MA0524.2	6.16e-13	5.26e-10
39	MA0765.3	ETV5	MA0765.3	1.11e-12	9.5e-10
40	MA1966.1	TFAP4::ETV1	MA1966.1	1.33e-12	1.14e-09
41	MA1560.1	SOHLH2	MA1560.1	1.82e-12	1.56e-09
42	MA0821.2	HES5	MA0821.2	3.19e-12	2.72e-09
43	MA0811.1	TFAP2B	MA0811.1	3.25e-12	2.78e-09
44	MA0156.3	FEV	MA0156.3	5.77e-12	4.92e-09
45	MA1545.1	OVOL2	MA1545.1	8.77e-12	7.49e-09
46	MA1727.1	ZNF417	MA1727.1	1.44e-11	1.23e-08
2	MA1713.1 (ZNF610)	MEME-3	SCSGSSGCGGSSSCG	2.72e-45	1.4e-08
47	MA1099.2	HES1	MA1099.2	1.96e-11	1.67e-08
48	MA0098.3	ETS1	MA0098.3	3.74e-11	3.2e-08
49	MA1569.1	TFAP2E	MA1569.1	3.77e-11	3.22e-08
50	MA1961.1	PATZ1	MA1961.1	4.01e-11	3.42e-08
51	MA0733.1	EGR4	MA0733.1	4.47e-11	3.82e-08
52	MA1102.2	CTCFL	MA1102.2	4.7e-11	4.02e-08
53	MA0475.2	FLI1	MA0475.2	4.93e-11	4.21e-08
104	MA1107.2 (KLF9)	MEME-2	TGTGTGTGTGTGTGT	1.73e-05	5.4e-08
54	MA0259.1	ARNT::HIF1A	MA0259.1	7.69e-11	6.57e-08
55	MA1684.1	Foxn1	MA1684.1	1.26e-10	1.08e-07
56	MA1596.1	ZNF460	MA1596.1	1.86e-10	1.59e-07
57	MA0750.2	ZBTB7A	MA0750.2	1.89e-10	1.61e-07
58	MA0695.1	ZBTB7C	MA0695.1	2.2e-10	1.88e-07
59	MA0872.1	TFAP2A	MA0872.1	5.76e-10	4.92e-07
60	MA1971.1	ZBED2	MA1971.1	8.84e-10	7.55e-07
61	MA0645.1	ETV6	MA0645.1	1.16e-09	9.93e-07
62	MA0763.1	ETV3	MA0763.1	2.04e-09	1.74e-06
63	MA1522.1	MAZ	MA1522.1	2.04e-09	1.75e-06
64	MA1976.1	ZNF320	MA1976.1	2.62e-09	2.24e-06
65	MA0649.1	HEY2	MA0649.1	3.65e-09	3.12e-06
66	MA1583.1	ZFP57	MA1583.1	3.8e-09	3.25e-06
1	MA1961.1 (PATZ1)	STREME-1	1-CGCCSCCGCCSCSSS	1.61e-45	7.11e-06
67	MA1648.1	TCF12	MA1648.1	8.42e-09	7.19e-06
68	MA1484.1	ETS2	MA1484.1	8.6e-09	7.35e-06
69	MA0076.2	ELK4	MA0076.2	1.23e-08	1.05e-05
70	MA0736.1	GLIS2	MA0736.1	2.43e-08	2.07e-05
71	MA0616.2	HES2	MA0616.2	3.05e-08	2.6e-05
72	MA0830.2	TCF4	MA0830.2	3.41e-08	2.91e-05
73	MA1719.1	ZNF816	MA1719.1	4.41e-08	3.77e-05
31	MA0076.2 (ELK4)	STREME-2	2-CCGGAAGCCG	4.32e-15	3.79e-05
74	MA0104.4	MYCN	MA0104.4	5.34e-08	4.56e-05
75	MA1548.1	PLAGL2	MA1548.1	5.69e-08	4.86e-05
76	MA1708.1	ETV7	MA1708.1	1.4e-07	0.000119
77	MA0516.3	SP2	MA0516.3	1.52e-07	0.00013
78	MA0471.2	E2F6	MA0471.2	3.05e-07	0.00026
79	MA1653.1	ZNF148	MA1653.1	3.47e-07	0.000296
80	MA1533.1	NR1I2	MA1533.1	4.19e-07	0.000358
81	MA0067.2	PAX2	MA0067.2	5.58e-07	0.000477
82	MA1990.1	Gli1	MA1990.1	5.77e-07	0.000493
83	MA1651.1	ZFP42	MA1651.1	5.84e-07	0.000499
84	MA1929.1	CTCF	MA1929.1	5.88e-07	0.000502
85	MA1973.1	ZKSCAN3	MA1973.1	9.46e-07	0.000808
4	MA0506.2 (Nrf1)	STREME-3	3-GCGCCGGCGC	4.1e-41	0.00117
86	MA0147.3	MYC	MA0147.3	1.48e-06	0.00126
87	MA1931.1	ELK1::HOXA1	MA1931.1	1.7e-06	0.00145
88	MA0004.1	Arnt	MA0004.1	1.87e-06	0.00159
89	MA1474.1	CREB3L4	MA1474.1	1.97e-06	0.00168
90	MA1712.1	ZNF454	MA1712.1	2.15e-06	0.00184
91	MA1941.1	ETV2::FIGLA	MA1941.1	2.58e-06	0.00221
92	MA0812.1	TFAP2B	MA0812.1	3.06e-06	0.00262
93	MA1515.1	KLF2	MA1515.1	4.6e-06	0.00393
94	MA0146.2	Zfx	MA0146.2	5.83e-06	0.00498
95	MA1934.1	ERF::FIGLA	MA1934.1	7.25e-06	0.00619
96	MA0145.2	Tfcp2l1	MA0145.2	8.61e-06	0.00736
8	MA0865.2 (E2F8)	STREME-4	4-CGGGAG	1.32e-33	0.0074
97	MA0734.3	Gli2	MA0734.3	8.9e-06	0.0076
10	MA1650.1 (ZBTB14)	STREME-5	5-CGCGCAG	1.88e-28	0.00805
98	MA0862.1	GMEB2	MA0862.1	9.62e-06	0.00822
99	MA0646.1	GCM1	MA0646.1	9.89e-06	0.00845
100	MA0863.1	MTF1	MA0863.1	1.01e-05	0.00863
101	MA1716.1	ZNF76	MA1716.1	1.07e-05	0.0091
102	MA1711.1	ZNF343	MA1711.1	1.2e-05	0.0102
103	MA1464.1	ARNT2	MA1464.1	1.6e-05	0.0136
105	MA1584.1	ZIC5	MA1584.1	1.74e-05	0.0148
106	MA0522.3	TCF3	MA0522.3	2.04e-05	0.0174
23	MA1938.1 (ERF::NHLH1)	STREME-6	6-CGGCAGC	1.38e-17	0.0177
107	MA0694.1	ZBTB7B	MA0694.1	2.12e-05	0.0181
108	MA1635.1	BHLHE22	MA1635.1	2.96e-05	0.0253
109	MA1564.1	SP9	MA1564.1	3.46e-05	0.0295
110	MA0751.1	ZIC4	MA0751.1	3.52e-05	0.0301
111	MA1578.1	VEZF1	MA1578.1	3.55e-05	0.0303
112	MA0597.2	THAP1	MA0597.2	5.11e-05	0.0436
113	MA0760.1	ERF	MA0760.1	5.46e-05	0.0466
3	7-CTCSGGCCGG	STREME-7	7-CTCSGGCCGG	1.35e-43	0.053
11	8-HCSSSGD	STREME-8	8-HCSSSGD	8.08e-25	0.0688
6	MA1713.1 (ZNF610)	STREME-9	9-GCGGCC	7.98e-39	0.0821
17	10-YGSACGW	STREME-10	10-YGSACGW	1.02e-21	4.94

EAR_close_xstreme %>% 
  dplyr::select(RANK,SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
  arrange(.,EVALUE) %>% 
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  # dplyr::filter(., EVALUE<0.05) %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs in EAR close") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs in EAR close
RANK	SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
1	MA0477.2	FOSL1	MA0477.2	4.1e-93	3.55e-90
2	MA0489.2	Jun	MA0489.2	5.02e-88	4.35e-85
3	MA0490.2	JUNB	MA0490.2	5.4e-87	4.68e-84
5	MA0099.3	FOS::JUN	MA0099.3	2.02e-85	1.75e-82
6	MA1130.1	FOSL2::JUN	MA1130.1	4.88e-85	4.23e-82
7	MA0491.2	JUND	MA0491.2	2.41e-83	2.09e-80
8	MA1141.1	FOS::JUND	MA1141.1	1.24e-82	1.08e-79
9	MA1928.1	BNC2	MA1928.1	1.69e-82	1.47e-79
10	MA1144.1	FOSL2::JUND	MA1144.1	2.01e-82	1.74e-79
11	MA1634.1	BATF	MA1634.1	3.56e-82	3.08e-79
12	MA0462.2	BATF::JUN	MA0462.2	3.59e-82	3.11e-79
13	MA0835.2	BATF3	MA0835.2	1.93e-81	1.68e-78
14	MA1633.2	BACH1	MA1633.2	5.68e-81	4.92e-78
15	MA1138.1	FOSL2::JUNB	MA1138.1	6.58e-80	5.7e-77
16	MA0841.1	NFE2	MA0841.1	1.94e-77	1.68e-74
17	MA1988.1	Atf3	MA1988.1	7.55e-77	6.54e-74
18	MA1134.1	FOS::JUNB	MA1134.1	6.56e-74	5.69e-71
19	MA0478.1	FOSL2	MA0478.1	9.68e-74	8.39e-71
20	MA1101.2	BACH2	MA1101.2	2.21e-73	1.92e-70
21	MA0476.1	FOS	MA0476.1	2.69e-72	2.33e-69
22	MA0655.1	JDP2	MA0655.1	6.35e-72	5.51e-69
23	MA1137.1	FOSL1::JUNB	MA1137.1	3.87e-71	3.36e-68
24	MA1128.1	FOSL1::JUN	MA1128.1	1.19e-68	1.03e-65
25	MA1142.1	FOSL1::JUND	MA1142.1	4.84e-67	4.2e-64
26	MA1135.1	FOSB::JUNB	MA1135.1	6.93e-67	6.01e-64
27	MA0501.1	MAF::NFE2	MA0501.1	3.17e-61	2.75e-58
28	MA0766.2	GATA5	MA0766.2	2.45e-60	2.13e-57
29	MA0089.2	MAFG::NFE2L1	MA0089.2	2.62e-59	2.27e-56
30	MA1132.1	JUN::JUNB	MA1132.1	3.14e-59	2.72e-56
33	MA0496.3	MAFK	MA0496.3	1.67e-51	1.45e-48
330	MA1125.1 (ZNF384)	MEME-1	WTTTTTTTTTTTTTT	4.13e-10	1.5e-48
34	MA0150.2	Nfe2l2	MA0150.2	5.26e-51	4.56e-48
36	MA0036.3	GATA2	MA0036.3	2.16e-47	1.87e-44
37	MA0774.1	MEIS2	MA0774.1	4.9e-47	4.24e-44
38	MA0018.4	CREB1	MA0018.4	9.34e-46	8.1e-43
39	MA0037.4	Gata3	MA0037.4	4.79e-43	4.15e-40
41	MA1970.1	TRPS1	MA1970.1	1.23e-40	1.07e-37
42	MA0782.2	PKNOX1	MA0782.2	1.29e-39	1.12e-36
46	MA1652.1 (ZKSCAN5)	MEME-2	KRRGRWGGVRGDGAG	3.23e-35	1.7e-34
44	MA1632.1	ATF2	MA1632.1	2.7e-36	2.34e-33
45	MA1104.2	GATA6	MA1104.2	1.32e-35	1.15e-32
48	MA0482.2	GATA4	MA0482.2	1.21e-34	1.05e-31
50	MA1114.1	PBX3	MA1114.1	5.05e-33	4.38e-30
51	MA0035.4	GATA1	MA0035.4	6.45e-33	5.6e-30
52	MA0140.2	GATA1::TAL1	MA0140.2	2.15e-32	1.87e-29
53	MA0775.1	MEIS3	MA0775.1	5.89e-32	5.1e-29
55	MA0797.1	TGIF2	MA0797.1	3.88e-31	3.37e-28
57	MA0842.2	NRL	MA0842.2	8.98e-30	7.79e-27
59	MA0612.2	EMX1	MA0612.2	1.45e-29	1.26e-26
86	GCTGGAGTGCAGTGG	MEME-3	GCTGGAGTGCAGTGG	2.2e-22	7.7e-26
60	MA0707.2	MNX1	MA0707.2	7.41e-28	6.42e-25
61	MA0676.1	Nr2e1	MA0676.1	9.62e-28	8.34e-25
62	MA1480.1	DPRX	MA1480.1	1.22e-27	1.06e-24
63	MA0829.2	SREBF1	MA0829.2	5.49e-27	4.76e-24
64	MA0681.2	PHOX2B	MA0681.2	5.89e-26	5.1e-23
65	MA0070.1	PBX1	MA0070.1	8.7e-26	7.55e-23
66	MA1519.1	LHX5	MA1519.1	1.77e-25	1.54e-22
68	MA1564.1	SP9	MA1564.1	3.78e-25	3.28e-22
69	MA1139.1	FOSL2::JUNB	MA1139.1	4.44e-25	3.85e-22
70	MA1495.1	HOXA1	MA1495.1	8.78e-25	7.61e-22
71	MA0753.2	ZNF740	MA0753.2	2.48e-24	2.15e-21
72	MA1145.1	FOSL2::JUND	MA1145.1	3.36e-24	2.91e-21
73	MA1653.1	ZNF148	MA1653.1	4.79e-24	4.16e-21
74	MA0498.2	MEIS1	MA0498.2	5.18e-24	4.49e-21
75	MA1512.1	KLF11	MA1512.1	1e-23	8.68e-21
76	MA0596.1	SREBF2	MA0596.1	1.08e-23	9.37e-21
77	MA0599.1	KLF5	MA0599.1	1.54e-23	1.33e-20
78	MA0659.3	Mafg	MA0659.3	1.68e-23	1.46e-20
79	MA0595.1	SREBF1	MA0595.1	1.8e-23	1.56e-20
80	MA0661.1	MEOX1	MA0661.1	2.31e-23	2.01e-20
81	MA0611.2	Dux	MA0611.2	3.39e-23	2.94e-20
82	MA0492.1	JUND	MA0492.1	4.82e-23	4.18e-20
83	MA0027.2	EN1	MA0027.2	7.92e-23	6.87e-20
84	MA0039.4	KLF4	MA0039.4	1.04e-22	8.97e-20
85	MA1110.2	Nr1H4	MA1110.2	1.85e-22	1.6e-19
87	MA0904.2	HOXB5	MA0904.2	3.21e-22	2.78e-19
88	MA1593.1	ZNF317	MA1593.1	5.59e-22	4.85e-19
89	MA0886.1	EMX2	MA0886.1	6.01e-22	5.21e-19
90	MA1511.2	KLF10	MA1511.2	8.57e-22	7.43e-19
117	RGRGTCTYRCTCTGT	MEME-6	RGRGTCTYRCTCTGT	3.52e-19	1.4e-18
91	MA0742.2	KLF12	MA0742.2	1.64e-21	1.42e-18
181	GCCTGTAATCCCAGC	MEME-4	GCCTGTAATCCCAGC	3.37e-15	1.5e-18
92	MA1107.2	KLF9	MA1107.2	3.04e-21	2.64e-18
93	MA0881.1	Dlx4	MA0881.1	4.6e-21	3.99e-18
94	MA0631.1	Six3	MA0631.1	5.23e-21	4.54e-18
95	MA0709.1	Msx3	MA0709.1	6.26e-21	5.43e-18
96	MA1959.1	KLF7	MA1959.1	6.31e-21	5.47e-18
97	MA1571.1	TGIF2LX	MA1571.1	6.63e-21	5.75e-18
98	MA0880.1	Dlx3	MA0880.1	8.29e-21	7.19e-18
99	MA0666.2	MSX1	MA0666.2	8.82e-21	7.64e-18
100	MA0705.1	Lhx8	MA0705.1	1.23e-20	1.07e-17
101	MA1143.1	FOSL1::JUND	MA1143.1	1.28e-20	1.11e-17
102	MA1530.1	NKX6-3	MA1530.1	2.13e-20	1.85e-17
103	MA1129.1	FOSL1::JUN	MA1129.1	3.06e-20	2.65e-17
105	MA0685.2	SP4	MA0685.2	5.01e-20	4.35e-17
106	MA0516.3	SP2	MA0516.3	7.14e-20	6.19e-17
107	MA0132.2	PDX1	MA0132.2	7.24e-20	6.28e-17
108	MA0882.1	DLX6	MA0882.1	8.06e-20	6.99e-17
109	MA0741.1	KLF16	MA0741.1	1.08e-19	9.34e-17
110	MA0680.2	Pax7	MA0680.2	1.11e-19	9.63e-17
111	MA0628.1	POU6F1	MA0628.1	1.13e-19	9.83e-17
112	MA0654.1	ISX	MA0654.1	1.22e-19	1.06e-16
113	MA0688.1	TBX2	MA0688.1	1.26e-19	1.09e-16
114	MA0894.1	HESX1	MA0894.1	1.7e-19	1.47e-16
115	MA0644.2	ESX1	MA0644.2	2.36e-19	2.05e-16
116	MA1522.1	MAZ	MA1522.1	2.98e-19	2.58e-16
118	MA0802.1	TBR1	MA0802.1	4.51e-19	3.91e-16
119	MA0912.2	HOXD3	MA0912.2	5.43e-19	4.71e-16
120	MA0117.2	Mafb	MA0117.2	1.09e-18	9.48e-16
121	MA0902.2	HOXB2	MA0902.2	1.23e-18	1.07e-15
122	MA1572.1	TGIF2LY	MA1572.1	1.52e-18	1.31e-15
123	MA0805.1	TBX1	MA0805.1	2.83e-18	2.45e-15
124	MA1578.1	VEZF1	MA1578.1	2.95e-18	2.56e-15
125	MA1535.1	NR2C1	MA1535.1	3.56e-18	3.09e-15
126	MA0889.1	GBX1	MA0889.1	3.63e-18	3.14e-15
127	MA0708.2	MSX2	MA0708.2	3.73e-18	3.23e-15
128	MA1720.1	ZNF85	MA1720.1	4.72e-18	4.09e-15
129	MA1618.1	Ptf1a	MA1618.1	5.6e-18	4.85e-15
130	MA0803.1	TBX15	MA0803.1	6.04e-18	5.24e-15
131	MA0690.2	TBX21	MA0690.2	6.13e-18	5.31e-15
132	MA0162.4	EGR1	MA0162.4	6.18e-18	5.36e-15
134	MA0495.3	MAFF	MA0495.3	6.98e-18	6.05e-15
135	MA1710.1	ZNF257	MA1710.1	7.54e-18	6.54e-15
136	MA0740.2	KLF14	MA0740.2	8.03e-18	6.96e-15
137	MA1630.2	ZNF281	MA1630.2	8.34e-18	7.23e-15
138	MA1996.1	Nr1H2	MA1996.1	9.66e-18	8.37e-15
139	MA0710.1	NOTO	MA0710.1	1.29e-17	1.12e-14
140	MA0691.1	TFAP4	MA0691.1	1.48e-17	1.28e-14
141	MA0806.1	TBX4	MA0806.1	1.54e-17	1.33e-14
142	MA0258.2	ESR2	MA0258.2	1.9e-17	1.65e-14
143	MA0704.1	Lhx4	MA0704.1	2.49e-17	2.16e-14
144	MA2003.1	NKX2-4	MA2003.1	3.82e-17	3.31e-14
145	MA0672.1	NKX2-3	MA0672.1	3.86e-17	3.34e-14
146	MA0528.2	ZNF263	MA0528.2	3.92e-17	3.4e-14
147	MA0700.2	LHX2	MA0700.2	4e-17	3.47e-14
148	MA0093.3	USF1	MA0093.3	4.5e-17	3.9e-14
149	MA0620.3	MITF	MA0620.3	8.27e-17	7.17e-14
150	MA0879.2	DLX1	MA0879.2	9.57e-17	8.3e-14
151	MA0746.2	SP3	MA0746.2	1.15e-16	9.98e-14
152	MA0713.1	PHOX2A	MA0713.1	1.27e-16	1.1e-13
153	MA0726.1	VSX2	MA0726.1	1.4e-16	1.22e-13
154	MA1723.1	PRDM9	MA1723.1	1.62e-16	1.41e-13
155	MA0483.1	Gfi1B	MA0483.1	1.69e-16	1.47e-13
156	MA0017.2	NR2F1	MA0017.2	1.7e-16	1.48e-13
157	MA1119.1	SIX2	MA1119.1	1.79e-16	1.55e-13
158	MA0014.3	PAX5	MA0014.3	2.36e-16	2.05e-13
159	MA0800.1	EOMES	MA0800.1	3.49e-16	3.02e-13
160	MA0910.2	HOXD8	MA0910.2	3.68e-16	3.19e-13
161	MA0717.1	RAX2	MA0717.1	3.78e-16	3.27e-13
162	MA1566.2	TBX3	MA1566.2	3.98e-16	3.45e-13
163	MA1146.1	NR1H4::RXRA	MA1146.1	4.31e-16	3.74e-13
164	MA1505.1	HOXC8	MA1505.1	4.61e-16	4e-13
165	MA1729.1	ZNF680	MA1729.1	5.1e-16	4.42e-13
166	MA1481.1	DRGX	MA1481.1	5.31e-16	4.6e-13
167	MA0674.1	NKX6-1	MA0674.1	6.43e-16	5.58e-13
168	MA1108.2	MXI1	MA1108.2	8.62e-16	7.47e-13
169	MA1960.1	MGA::EVX1	MA1960.1	1.01e-15	8.72e-13
170	MA0673.1	NKX2-8	MA0673.1	1.05e-15	9.1e-13
171	MA0591.1	Bach1::Mafk	MA0591.1	1.09e-15	9.45e-13
173	MA1644.1	NFYC	MA1644.1	1.26e-15	1.09e-12
174	MA0747.1	SP8	MA0747.1	1.32e-15	1.14e-12
175	MA1961.1	PATZ1	MA1961.1	1.62e-15	1.41e-12
176	MA0900.2	HOXA2	MA0900.2	1.68e-15	1.45e-12
177	MA1102.2	CTCFL	MA1102.2	1.82e-15	1.57e-12
570	TGTGTGTGTGTGTGT	MEME-5	TGTGTGTGTGTGTGT	0.614	1.7e-12
178	MA0719.1	RHOXF1	MA0719.1	2.01e-15	1.74e-12
179	MA1474.1	CREB3L4	MA1474.1	2.72e-15	2.36e-12
180	MA0715.1	PROP1	MA0715.1	3.27e-15	2.83e-12
182	MA1476.2	Dlx5	MA1476.2	3.54e-15	3.07e-12
183	MA1994.1	Nkx2-1	MA1994.1	3.83e-15	3.32e-12
184	MA0125.1	Nobox	MA0125.1	3.92e-15	3.39e-12
185	MA1615.1	Plagl1	MA1615.1	3.95e-15	3.42e-12
186	MA0908.1	HOXD11	MA0908.1	4.87e-15	4.22e-12
187	MA0875.1	BARX1	MA0875.1	5.1e-15	4.42e-12
188	MA0883.1	Dmbx1	MA0883.1	5.28e-15	4.58e-12
189	MA1965.1	SP5	MA1965.1	5.34e-15	4.63e-12
190	MA0504.1	NR2C2	MA0504.1	6.76e-15	5.86e-12
191	MA1133.1	JUN::JUNB	MA1133.1	7.53e-15	6.53e-12
192	MA0807.1	TBX5	MA0807.1	7.87e-15	6.82e-12
193	MA1515.1	KLF2	MA1515.1	1.05e-14	9.08e-12
194	MA0052.4	MEF2A	MA0052.4	1.26e-14	1.09e-11
196	MA0626.1	Npas2	MA0626.1	1.92e-14	1.67e-11
197	MA1150.1	RORB	MA1150.1	2.11e-14	1.83e-11
198	MA0725.1	VSX1	MA0725.1	2.14e-14	1.85e-11
199	MA0079.5	SP1	MA0079.5	2.2e-14	1.91e-11
200	MA0689.1	TBX20	MA0689.1	2.46e-14	2.13e-11
201	MA1126.1	FOS::JUN	MA1126.1	2.98e-14	2.58e-11
202	MA0071.1	RORA	MA0071.1	3.03e-14	2.63e-11
203	MA0768.2	Lef1	MA0768.2	3.04e-14	2.64e-11
204	MA0075.3	PRRX2	MA0075.3	3.51e-14	3.04e-11
205	MA1147.1	NR4A2::RXRA	MA1147.1	4.48e-14	3.88e-11
206	MA1475.1	CREB3L4	MA1475.1	4.91e-14	4.26e-11
207	MA0639.1	DBP	MA0639.1	5.29e-14	4.58e-11
208	MA0701.2	LHX9	MA0701.2	7.45e-14	6.46e-11
209	MA0130.1	ZNF354C	MA0130.1	8.79e-14	7.62e-11
210	MA0833.2	ATF4	MA0833.2	1.08e-13	9.33e-11
211	MA0601.1	Arid3b	MA0601.1	1.09e-13	9.48e-11
212	MA1514.1	KLF17	MA1514.1	1.23e-13	1.07e-10
213	MA0642.2	EN2	MA0642.2	1.25e-13	1.09e-10
214	MA0761.2	ETV1	MA0761.2	1.27e-13	1.1e-10
215	MA1463.1	ARGFX	MA1463.1	1.42e-13	1.23e-10
216	MA1587.1	ZNF135	MA1587.1	1.63e-13	1.41e-10
217	MA0063.2	NKX2-5	MA0063.2	1.63e-13	1.41e-10
218	MA1995.1	Npas4	MA1995.1	1.7e-13	1.48e-10
219	MA1636.1	CEBPG	MA1636.1	1.99e-13	1.73e-10
220	MA1643.1	NFIB	MA1643.1	2.01e-13	1.74e-10
221	MA1567.2	Tbx6	MA1567.2	2.04e-13	1.77e-10
222	MA0748.2	YY2	MA0748.2	2.17e-13	1.89e-10
223	MA0043.3	HLF	MA0043.3	2.24e-13	1.94e-10
224	MA1112.2	NR4A1	MA1112.2	2.37e-13	2.05e-10
225	MA0714.1	PITX3	MA0714.1	3.38e-13	2.93e-10
227	MA0500.2	MYOG	MA0500.2	4.01e-13	3.48e-10
229	MA0597.2	THAP1	MA0597.2	4.51e-13	3.91e-10
230	MA1652.1	ZKSCAN5	MA1652.1	5e-13	4.33e-10
231	MA0695.1	ZBTB7C	MA0695.1	5.28e-13	4.57e-10
232	MA0060.3	NFYA	MA0060.3	5.6e-13	4.86e-10
233	MA1136.1	FOSB::JUNB	MA1136.1	6.64e-13	5.75e-10
234	MA1972.1	ZFP14	MA1972.1	7.01e-13	6.08e-10
235	MA0733.1	EGR4	MA0733.1	7.35e-13	6.37e-10
236	MA0718.1	RAX	MA0718.1	7.65e-13	6.63e-10
237	MA0845.1	FOXB1	MA0845.1	7.77e-13	6.74e-10
238	MA1650.1	ZBTB14	MA1650.1	8.36e-13	7.24e-10
239	MA0029.1	Mecom	MA0029.1	8.94e-13	7.75e-10
240	MA0031.1	FOXD1	MA0031.1	9.74e-13	8.45e-10
241	MA0903.1	HOXB3	MA0903.1	1.33e-12	1.15e-09
242	MA1577.1	TLX2	MA1577.1	1.42e-12	1.23e-09
243	MA1547.2	PITX2	MA1547.2	1.55e-12	1.34e-09
244	MA0801.1	MGA	MA0801.1	1.65e-12	1.43e-09
245	MA1113.2	PBX2	MA1113.2	1.72e-12	1.49e-09
246	MA1640.1	MEIS2	MA1640.1	1.86e-12	1.61e-09
247	MA0098.3	ETS1	MA0098.3	1.89e-12	1.64e-09
248	MA0820.1	FIGLA	MA0820.1	2.43e-12	2.11e-09
249	MA1974.1	ZNF211	MA1974.1	2.55e-12	2.21e-09
250	MA0141.3	ESRRB	MA0141.3	2.56e-12	2.22e-09
251	MA1639.1	MEIS1	MA1639.1	2.7e-12	2.34e-09
252	MA0003.4	TFAP2A	MA0003.4	3e-12	2.6e-09
253	MA1520.1	MAF	MA1520.1	3.25e-12	2.81e-09
254	MA0890.1	GBX2	MA0890.1	3.62e-12	3.14e-09
255	MA0698.1	ZBTB18	MA0698.1	3.64e-12	3.15e-09
256	MA0124.2	Nkx3-1	MA0124.2	3.65e-12	3.16e-09
257	MA1536.1	NR2C2	MA1536.1	3.98e-12	3.45e-09
258	MA0899.1	HOXA10	MA0899.1	4.23e-12	3.67e-09
259	MA0667.1	MYF6	MA0667.1	4.32e-12	3.74e-09
260	MA1467.2	Atoh1	MA1467.2	4.41e-12	3.82e-09
261	MA0142.1	Pou5f1::Sox2	MA0142.1	4.99e-12	4.33e-09
262	MA0602.1	Arid5a	MA0602.1	5e-12	4.34e-09
263	MA0724.1	VENTX	MA0724.1	5.24e-12	4.54e-09
264	MA0158.2	HOXA5	MA0158.2	5.27e-12	4.57e-09
265	MA1500.1	HOXB6	MA1500.1	6.16e-12	5.34e-09
266	MA1523.1	MSANTD3	MA1523.1	6.68e-12	5.79e-09
267	MA0046.2	HNF1A	MA0046.2	7.07e-12	6.13e-09
268	MA1570.1	TFAP4	MA1570.1	7.53e-12	6.53e-09
269	MA0769.2	TCF7	MA0769.2	7.75e-12	6.72e-09
270	MA0523.1	TCF7L2	MA0523.1	9.12e-12	7.9e-09
271	MA0468.1	DUX4	MA0468.1	1.01e-11	8.71e-09
272	MA1503.1	HOXB9	MA1503.1	1.02e-11	8.87e-09
273	MA1621.1	Rbpjl	MA1621.1	1.09e-11	9.43e-09
274	MA1521.1	MAFA	MA1521.1	1.13e-11	9.78e-09
275	MA0658.1	LHX6	MA0658.1	1.15e-11	9.99e-09
276	MA0656.1	JDP2	MA0656.1	1.18e-11	1.03e-08
277	MA1986.1	ZNF692	MA1986.1	1.31e-11	1.14e-08
278	MA0095.3	Yy1	MA0095.3	1.42e-11	1.24e-08
279	MA0675.1	NKX6-2	MA0675.1	1.52e-11	1.32e-08
280	MA0621.1	mix-a	MA0621.1	1.57e-11	1.37e-08
281	MA1728.1	ZNF549	MA1728.1	2.42e-11	2.1e-08
282	MA1991.1	Hnf1A	MA1991.1	2.8e-11	2.43e-08
283	MA0151.1	Arid3a	MA0151.1	2.8e-11	2.43e-08
284	MA0830.2	TCF4	MA0830.2	2.91e-11	2.52e-08
285	MA1109.1	NEUROD1	MA1109.1	3.27e-11	2.83e-08
286	MA0684.2	RUNX3	MA0684.2	3.34e-11	2.9e-08
287	MA0143.4	SOX2	MA0143.4	3.89e-11	3.37e-08
288	MA1707.1	DMRTA1	MA1707.1	4.12e-11	3.57e-08
289	MA0682.2	PITX1	MA0682.2	4.36e-11	3.78e-08
290	MA0788.1	POU3F3	MA0788.1	4.85e-11	4.21e-08
291	MA1651.1	ZFP42	MA1651.1	5.08e-11	4.4e-08
292	MA0767.1	GCM2	MA0767.1	5.18e-11	4.49e-08
293	MA1527.1	NFIC	MA1527.1	5.26e-11	4.56e-08
294	MA0734.3	Gli2	MA0734.3	5.31e-11	4.61e-08
295	MA0515.1	Sox6	MA0515.1	5.39e-11	4.67e-08
296	MA0122.3	Nkx3-2	MA0122.3	5.55e-11	4.81e-08
297	MA0648.1	GSC	MA0648.1	6.15e-11	5.33e-08
298	MA0692.1	TFEB	MA0692.1	6.85e-11	5.94e-08
299	MA0669.1	NEUROG2	MA0669.1	7.16e-11	6.21e-08
300	MA0751.1	ZIC4	MA0751.1	8.42e-11	7.3e-08
301	MA0650.3	Hoxa13	MA0650.3	8.54e-11	7.4e-08
302	MA0793.1	POU6F2	MA0793.1	9.27e-11	8.04e-08
303	MA1152.1	SOX15	MA1152.1	1.01e-10	8.74e-08
304	MA1979.1	ZNF416	MA1979.1	1.01e-10	8.8e-08
305	MA1565.1	TBX18	MA1565.1	1.04e-10	9e-08
306	MA1990.1	Gli1	MA1990.1	1.08e-10	9.33e-08
307	MA0119.1	NFIC::TLX1	MA0119.1	1.09e-10	9.45e-08
308	MA0901.2	HOXB13	MA0901.2	1.11e-10	9.59e-08
309	MA0892.1	GSX1	MA0892.1	1.12e-10	9.75e-08
226	MA1710.1 (ZNF257)	MEME-7	CTGAGGCAGGAGRAT	3.49e-13	1e-07
310	MA0831.3	TFE3	MA0831.3	1.54e-10	1.33e-07
311	MA0102.4	CEBPA	MA0102.4	1.6e-10	1.39e-07
312	MA1629.1	Zic2	MA1629.1	1.64e-10	1.42e-07
313	MA0511.2	RUNX2	MA0511.2	1.71e-10	1.48e-07
314	MA1501.1	HOXB7	MA1501.1	1.73e-10	1.5e-07
315	MA1504.1	HOXC4	MA1504.1	1.97e-10	1.71e-07
316	MA0025.2	NFIL3	MA0025.2	2.06e-10	1.78e-07
317	MA0664.1	MLXIPL	MA0664.1	2.38e-10	2.06e-07
318	MA0136.3	Elf5	MA0136.3	2.46e-10	2.13e-07
319	MA0712.2	OTX2	MA0712.2	2.47e-10	2.14e-07
320	MA1502.1	HOXB8	MA1502.1	2.58e-10	2.24e-07
321	MA1120.1	SOX13	MA1120.1	2.69e-10	2.33e-07
322	MA1950.1	FLI1::FOXI1	MA1950.1	2.74e-10	2.38e-07
323	MA0706.1	MEOX2	MA0706.1	3.15e-10	2.73e-07
324	MA1468.1	ATOH7	MA1468.1	3.22e-10	2.79e-07
325	MA0465.2	CDX2	MA0465.2	3.27e-10	2.84e-07
326	MA1516.1	KLF3	MA1516.1	3.36e-10	2.91e-07
327	MA0905.1	HOXC10	MA0905.1	3.38e-10	2.93e-07
328	MA0723.2	VAX2	MA0723.2	3.5e-10	3.03e-07
329	MA1606.1	Foxf1	MA1606.1	3.6e-10	3.12e-07
331	MA0789.1	POU3F4	MA0789.1	4.43e-10	3.84e-07
332	MA0876.1	BSX	MA0876.1	4.68e-10	4.05e-07
333	MA0111.1	Spz1	MA0111.1	5.04e-10	4.37e-07
334	MA0846.1	FOXC2	MA0846.1	5.16e-10	4.47e-07
335	MA1713.1	ZNF610	MA1713.1	5.28e-10	4.58e-07
336	MA0032.2	FOXC1	MA0032.2	5.47e-10	4.75e-07
337	MA1631.1	ASCL1	MA1631.1	5.55e-10	4.82e-07
338	MA1645.1	NKX2-2	MA1645.1	5.58e-10	4.84e-07
339	MA1963.1	SATB1	MA1963.1	6.15e-10	5.33e-07
340	MA1528.1	NFIX	MA1528.1	6.18e-10	5.36e-07
341	MA0614.1	Foxj2	MA0614.1	7.14e-10	6.19e-07
342	MA1518.2	Lhx1	MA1518.2	7.92e-10	6.86e-07
343	MA0623.2	NEUROG1	MA0623.2	8.33e-10	7.22e-07
344	MA1131.1	FOSL2::JUN	MA1131.1	8.37e-10	7.26e-07
345	MA0711.1	OTX1	MA0711.1	8.99e-10	7.8e-07
346	MA0693.3	Vdr	MA0693.3	9.27e-10	8.04e-07
347	MA0630.1	SHOX	MA0630.1	9.82e-10	8.52e-07
348	MA0884.2	DUXA	MA0884.2	1.01e-09	8.72e-07
349	MA1549.1	POU6F1	MA1549.1	1.04e-09	9.04e-07
350	MA0897.1	Hmx2	MA0897.1	1.11e-09	9.62e-07
352	MA0720.1	Shox2	MA0720.1	1.17e-09	1.02e-06
353	MA0522.3	TCF3	MA0522.3	1.2e-09	1.04e-06
354	MA1517.1	KLF6	MA1517.1	1.25e-09	1.09e-06
355	MA0041.2	FOXD3	MA0041.2	1.27e-09	1.1e-06
356	MA1574.1	THRB	MA1574.1	1.33e-09	1.15e-06
357	MA0699.1	LBX2	MA0699.1	1.36e-09	1.18e-06
358	MA1656.1	ZNF449	MA1656.1	1.38e-09	1.19e-06
359	MA0488.1	JUN	MA0488.1	1.51e-09	1.31e-06
360	MA0603.1	Arntl	MA0603.1	1.56e-09	1.35e-06
361	MA1483.2	ELF2	MA1483.2	1.66e-09	1.44e-06
362	MA0497.1	MEF2C	MA0497.1	1.76e-09	1.53e-06
363	MA1607.1	Foxl2	MA1607.1	1.82e-09	1.58e-06
364	MA1628.1	Zic1::Zic2	MA1628.1	2.04e-09	1.77e-06
365	MA0867.2	SOX4	MA0867.2	2.08e-09	1.8e-06
366	MA1977.1	ZNF324	MA1977.1	2.2e-09	1.91e-06
367	MA0745.2	SNAI2	MA0745.2	2.38e-09	2.06e-06
368	MA0754.2	CUX1	MA0754.2	2.65e-09	2.3e-06
369	MA1111.1	NR2F2	MA1111.1	2.65e-09	2.3e-06
370	MA0502.2	NFYB	MA0502.2	2.8e-09	2.43e-06
371	MA0847.3	FOXD2	MA0847.3	2.95e-09	2.55e-06
372	MA1603.1	Dmrt1	MA1603.1	2.99e-09	2.59e-06
373	MA0885.2	Dlx2	MA0885.2	2.99e-09	2.59e-06
374	MA0508.3	PRDM1	MA0508.3	3.2e-09	2.77e-06
375	MA0808.1	TEAD3	MA0808.1	3.32e-09	2.88e-06
376	MA1992.1	Ikzf3	MA1992.1	3.46e-09	3e-06
377	MA0721.1	UNCX	MA0721.1	3.61e-09	3.13e-06
378	MA1498.2	HOXA7	MA1498.2	3.66e-09	3.17e-06
379	MA1149.1	RARA::RXRG	MA1149.1	3.73e-09	3.24e-06
380	MA1731.1	ZNF768	MA1731.1	3.92e-09	3.4e-06
381	MA0467.2	Crx	MA0467.2	4.24e-09	3.68e-06
382	MA1620.1	Ptf1A	MA1620.1	4.32e-09	3.75e-06
383	MA0092.1	Hand1::Tcf3	MA0092.1	4.46e-09	3.86e-06
384	MA0499.2	MYOD1	MA0499.2	5.09e-09	4.41e-06
385	MA0613.1	FOXG1	MA0613.1	5.2e-09	4.51e-06
386	MA1944.1	ETV5::DRGX	MA1944.1	5.3e-09	4.6e-06
387	MA0834.1	ATF7	MA0834.1	5.83e-09	5.05e-06
388	MA0609.2	CREM	MA0609.2	6.61e-09	5.73e-06
389	MA1493.1	HES6	MA1493.1	6.67e-09	5.78e-06
390	MA0635.1	BARHL2	MA0635.1	6.84e-09	5.93e-06
391	MA1100.2	ASCL1	MA1100.2	7.19e-09	6.23e-06
392	MA0750.2	ZBTB7A	MA0750.2	7.22e-09	6.26e-06
393	MA1594.1	ZNF382	MA1594.1	7.36e-09	6.38e-06
394	MA1127.1	FOSB::JUN	MA1127.1	7.92e-09	6.87e-06
395	MA0814.2	TFAP2C	MA0814.2	8.05e-09	6.98e-06
396	MA0146.2	Zfx	MA0146.2	8.99e-09	7.79e-06
397	MA0042.2	FOXI1	MA0042.2	9.38e-09	8.14e-06
398	MA1987.1	ZNF701	MA1987.1	9.42e-09	8.17e-06
399	MA0816.1	Ascl2	MA0816.1	1.06e-08	9.18e-06
400	MA2002.1	Zfp335	MA2002.1	1.17e-08	1.01e-05
402	MA0479.1	FOXH1	MA0479.1	1.25e-08	1.09e-05
403	MA0153.2	HNF1B	MA0153.2	1.26e-08	1.1e-05
404	MA0019.1	Ddit3::Cebpa	MA0019.1	1.28e-08	1.11e-05
405	MA0810.1	TFAP2A	MA0810.1	1.33e-08	1.15e-05
406	MA0716.1	PRRX1	MA0716.1	1.36e-08	1.18e-05
407	MA0090.3	TEAD1	MA0090.3	1.43e-08	1.24e-05
408	MA0514.2	Sox3	MA0514.2	1.64e-08	1.42e-05
409	MA0683.1	POU4F2	MA0683.1	1.67e-08	1.45e-05
410	MA1478.1	DMRTA2	MA1478.1	1.97e-08	1.71e-05
4	MA1988.1 (Atf3)	STREME-1	1-BVTGASTCABV	5.65e-86	1.97e-05
411	MA1122.1	TFDP1	MA1122.1	2.34e-08	2.03e-05
412	MA0913.2	HOXD9	MA0913.2	2.51e-08	2.18e-05
413	MA1151.1	RORC	MA1151.1	2.53e-08	2.19e-05
414	MA0668.2	Neurod2	MA0668.2	2.72e-08	2.36e-05
415	MA0471.2	E2F6	MA0471.2	2.76e-08	2.39e-05
416	MA1558.1	SNAI1	MA1558.1	3.02e-08	2.61e-05
417	MA0157.3	Foxo3	MA0157.3	3.25e-08	2.81e-05
418	MA1497.1	HOXA6	MA1497.1	3.25e-08	2.82e-05
419	MA0645.1	ETV6	MA0645.1	3.34e-08	2.9e-05
420	MA0677.1	Nr2f6	MA0677.1	3.61e-08	3.13e-05
421	MA1683.1	FOXA3	MA1683.1	3.72e-08	3.23e-05
422	MA0006.1	Ahr::Arnt	MA0006.1	4.02e-08	3.48e-05
423	MA0909.3	Hoxd13	MA0909.3	4.15e-08	3.6e-05
424	MA1581.1	ZBTB6	MA1581.1	4.36e-08	3.78e-05
425	MA1125.1	ZNF384	MA1125.1	4.57e-08	3.96e-05
426	MA0481.3	FOXP1	MA0481.3	4.64e-08	4.02e-05
427	MA0081.2	SPIB	MA0081.2	4.7e-08	4.08e-05
428	MA0145.2	Tfcp2l1	MA0145.2	4.73e-08	4.1e-05
429	MA0047.3	FOXA2	MA0047.3	4.81e-08	4.17e-05
430	MA1604.1	Ebf2	MA1604.1	4.83e-08	4.19e-05
431	MA0838.1	CEBPG	MA0838.1	4.95e-08	4.29e-05
432	MA0722.1	VAX1	MA0722.1	5.32e-08	4.61e-05
433	MA0600.2	RFX2	MA0600.2	5.66e-08	4.91e-05
434	MA0744.2	SCRT2	MA0744.2	5.72e-08	4.96e-05
435	MA0077.1	SOX9	MA0077.1	6.28e-08	5.44e-05
49	2-AGATAT	STREME-2	2-AGATAT	2e-33	5.78e-05
436	MA0796.1	TGIF1	MA0796.1	6.86e-08	5.95e-05
437	MA0080.6	Spi1	MA0080.6	7.48e-08	6.49e-05
438	MA1619.1	Ptf1A	MA1619.1	7.62e-08	6.61e-05
439	MA1487.2	FOXE1	MA1487.2	7.82e-08	6.78e-05
440	MA0442.2	SOX10	MA0442.2	7.9e-08	6.85e-05
441	MA1984.1	ZNF667	MA1984.1	7.97e-08	6.91e-05
442	MA0868.2	SOX8	MA0868.2	8.03e-08	6.96e-05
443	MA0103.3	ZEB1	MA0103.3	8.05e-08	6.98e-05
444	MA1951.1	FOS	MA1951.1	8.62e-08	7.47e-05
445	MA1648.1	TCF12	MA1648.1	8.66e-08	7.51e-05
446	MA1953.1	FOXO1::ELF1	MA1953.1	9.49e-08	8.23e-05
447	MA1946.1	ETV5::FOXI1	MA1946.1	1e-07	8.68e-05
448	MA0859.1	Rarg	MA0859.1	1e-07	8.68e-05
449	MA0914.1	ISL2	MA0914.1	1.02e-07	8.82e-05
450	MA0809.2	TEAD4	MA0809.2	1.02e-07	8.82e-05
451	MA1978.1	ZNF354A	MA1978.1	1.07e-07	9.26e-05
452	MA1563.2	SOX18	MA1563.2	1.17e-07	0.000101
453	MA1954.1	FOXO1::ELK1	MA1954.1	1.17e-07	0.000101
454	MA0078.2	Sox17	MA0078.2	1.18e-07	0.000102
455	MA1479.1	DMRTC2	MA1479.1	1.36e-07	0.000118
456	MA0159.1	RARA::RXRA	MA0159.1	1.54e-07	0.000133
457	MA0634.1	ALX3	MA0634.1	1.54e-07	0.000133
458	MA0850.1	FOXP3	MA0850.1	1.58e-07	0.000137
459	MA0649.1	HEY2	MA0649.1	1.61e-07	0.000139
460	MA1717.1	ZNF784	MA1717.1	1.65e-07	0.000143
461	MA1641.1	MYF5	MA1641.1	1.73e-07	0.00015
462	MA0891.1	GSC2	MA0891.1	1.78e-07	0.000155
463	MA0473.3	ELF1	MA0473.3	1.8e-07	0.000156
464	MA0598.3	EHF	MA0598.3	1.86e-07	0.000161
465	MA0827.1	OLIG3	MA0827.1	2.02e-07	0.000175
466	MA1499.1	HOXB4	MA1499.1	2.18e-07	0.000189
467	MA1638.1	HAND2	MA1638.1	2.4e-07	0.000209
468	MA0002.2	Runx1	MA0002.2	2.43e-07	0.000211
469	MA0826.1	OLIG1	MA0826.1	2.46e-07	0.000213
470	MA0783.1	PKNOX2	MA0783.1	2.59e-07	0.000225
471	MA0837.2	CEBPE	MA0837.2	2.62e-07	0.000228
472	MA0893.2	GSX2	MA0893.2	2.64e-07	0.000229
473	MA1532.2	NR1D2	MA1532.2	3.1e-07	0.000269
474	MA0464.2	BHLHE40	MA0464.2	3.16e-07	0.000274
475	MA0144.2	STAT3	MA0144.2	3.18e-07	0.000276
476	MA1148.1	PPARA::RXRA	MA1148.1	3.37e-07	0.000292
477	MA0646.1	GCM1	MA0646.1	3.38e-07	0.000293
478	MA1421.1	TCF7L1	MA1421.1	3.42e-07	0.000297
479	MA0480.2	Foxo1	MA0480.2	3.63e-07	0.000315
480	MA0874.1	Arx	MA0874.1	3.68e-07	0.000319
481	MA0792.1	POU5F1B	MA0792.1	3.72e-07	0.000322
482	MA0524.2	TFAP2C	MA0524.2	3.79e-07	0.000329
483	MA0828.2	SREBF2	MA0828.2	4.03e-07	0.000349
484	MA0851.1	Foxj3	MA0851.1	4.42e-07	0.000383
485	MA0033.2	FOXL1	MA0033.2	4.51e-07	0.000391
486	MA0811.1	TFAP2B	MA0811.1	4.74e-07	0.000411
487	MA0738.1	HIC2	MA0738.1	4.79e-07	0.000415
488	MA1105.2	GRHL2	MA1105.2	5.48e-07	0.000475
489	MA0461.2	Atoh1	MA0461.2	5.78e-07	0.000501
490	MA1507.1	HOXD4	MA1507.1	6.23e-07	0.00054
32	MA0498.2 (MEIS1)	STREME-3	3-STGWCAS	1.56e-52	0.000544
491	MA0076.2	ELK4	MA0076.2	6.42e-07	0.000557
492	MA0849.1	FOXO6	MA0849.1	6.46e-07	0.00056
228	MA1645.1 (NKX2-2)	STREME-4	4-CTACTCAG	4.28e-13	0.000563
493	MA0160.2	NR4A2	MA0160.2	6.82e-07	0.000591
494	MA1472.2	Bhlha15	MA1472.2	7.15e-07	0.00062
495	MA1719.1	ZNF816	MA1719.1	8.24e-07	0.000714
496	MA1534.1	NR1I3	MA1534.1	8.87e-07	0.000769
497	MA1596.1	ZNF460	MA1596.1	9.34e-07	0.00081
498	MA1484.1	ETS2	MA1484.1	9.81e-07	0.000851
499	MA1116.1	RBPJ	MA1116.1	9.84e-07	0.000853
500	MA1124.1	ZNF24	MA1124.1	9.96e-07	0.000864
501	MA0521.2	Tcf12	MA0521.2	9.99e-07	0.000866
502	MA0104.4	MYCN	MA0104.4	1e-06	0.00087
503	MA0148.4	FOXA1	MA0148.4	1.02e-06	0.000888
504	MA1976.1	ZNF320	MA1976.1	1.07e-06	0.000925
505	MA1637.1	EBF3	MA1637.1	1.45e-06	0.00125
506	MA0493.2	KLF1	MA0493.2	1.51e-06	0.00131
507	MA0259.1	ARNT::HIF1A	MA0259.1	1.55e-06	0.00134
508	MA0475.2	FLI1	MA0475.2	1.55e-06	0.00135
509	MA0755.1	CUX2	MA0755.1	1.59e-06	0.00138
35	MA1962.1 (POU2F1::SOX2)	STREME-5	5-CATCACA	4.15e-49	0.00139
510	MA1489.1	FOXN3	MA1489.1	1.9e-06	0.00165
511	MA0887.1	EVX1	MA0887.1	1.96e-06	0.0017
31	MA0766.2 (GATA5)	STREME-6	6-WGATAASRD	9.24e-59	0.00173
512	MA0679.2	ONECUT1	MA0679.2	2.01e-06	0.00174
513	MA1721.1	ZNF93	MA1721.1	2.1e-06	0.00182
514	MA1583.1	ZFP57	MA1583.1	2.31e-06	0.002
515	MA0087.2	Sox5	MA0087.2	2.67e-06	0.00232
516	MA0627.2	POU2F3	MA0627.2	2.92e-06	0.00253
517	MA0494.1	Nr1h3::Rxra	MA0494.1	2.99e-06	0.00259
518	MA0852.2	FOXK1	MA0852.2	3.43e-06	0.00297
519	MA0791.1	POU4F3	MA0791.1	3.48e-06	0.00302
520	MA0030.1	FOXF2	MA0030.1	3.59e-06	0.00311
521	MA0068.2	PAX4	MA0068.2	3.69e-06	0.0032
522	MA1573.2	Thap11	MA1573.2	3.95e-06	0.00343
523	MA1471.1	BARX2	MA1471.1	3.96e-06	0.00343
524	MA0640.2	ELF3	MA0640.2	4.25e-06	0.00369
133	MA1125.1 (ZNF384)	STREME-7	7-GTCTCWAAAAAAAA	6.53e-18	0.00383
525	MA1552.1	RARB	MA1552.1	4.58e-06	0.00397
526	MA1957.1	HOXB2::ELK1	MA1957.1	5.26e-06	0.00456
47	MA0038.2 (GFI1)	STREME-8	8-CTCACTGCA	1.06e-34	0.00474
527	MA1642.1	NEUROG2	MA1642.1	6.16e-06	0.00534
528	MA1624.1	Stat5a	MA1624.1	6.7e-06	0.00581
529	MA1588.1	ZNF136	MA1588.1	8.04e-06	0.00697
530	MA0911.1	Hoxa11	MA0911.1	8.12e-06	0.00704
531	MA0739.1	Hic1	MA0739.1	8.34e-06	0.00723
532	MA0804.1	TBX19	MA0804.1	8.67e-06	0.00752
533	MA1542.1	OSR1	MA1542.1	9.21e-06	0.00798
534	MA0888.1	EVX2	MA0888.1	9.29e-06	0.00805
56	MA1965.1 (SP5)	STREME-9	9-CCTCCCA	3.96e-31	0.00821
535	MA0662.1	MIXL1	MA0662.1	9.51e-06	0.00824
536	MA0633.2	Twist2	MA0633.2	9.67e-06	0.00838
537	MA1555.1	RXRB	MA1555.1	9.81e-06	0.0085
538	MA1625.1	Stat5b	MA1625.1	1.07e-05	0.00929
539	MA1985.1	ZNF669	MA1985.1	1.08e-05	0.00936
540	MA1496.1	HOXA4	MA1496.1	1.16e-05	0.0101
541	MA1103.2	FOXK2	MA1103.2	1.17e-05	0.0101
542	MA1635.1	BHLHE22	MA1635.1	1.44e-05	0.0125
543	MA0878.3	CDX1	MA0878.3	1.62e-05	0.014
544	MA1524.2	Msgn1	MA1524.2	1.76e-05	0.0153
545	MA1712.1	ZNF454	MA1712.1	1.76e-05	0.0153
546	MA0108.2	TBP	MA0108.2	1.89e-05	0.0164
547	MA0697.2	Zic3	MA0697.2	1.96e-05	0.017
548	MA1948.1	ETV5::HOXA2	MA1948.1	1.99e-05	0.0172
549	MA0896.1	Hmx1	MA0896.1	2e-05	0.0173
54	10-AGGCAT	STREME-10	10-AGGCAT	7.79e-32	0.0178
550	MA1726.1	ZNF331	MA1726.1	2.37e-05	0.0206
43	11-CATCTAA	STREME-11	11-CATCTAA	1.83e-38	0.0207
195	MA0712.2 (OTX2)	STREME-12	12-CTGTAATCCCAG	1.51e-14	0.0212
551	MA0817.1	BHLHE23	MA0817.1	2.52e-05	0.0219
552	MA1121.1	TEAD2	MA1121.1	2.57e-05	0.0223
553	MA0038.2	GFI1	MA0038.2	2.7e-05	0.0234
554	MA0072.1	RORA	MA0072.1	2.94e-05	0.0255
555	MA1999.1	Prdm5	MA1999.1	3.19e-05	0.0276
351	MA1728.1 (ZNF549)	STREME-13	13-CTGGGCAACAGA	1.14e-09	0.0286
556	MA0131.2	HINFP	MA0131.2	3.32e-05	0.0288
557	MA1983.1	ZNF582	MA1983.1	3.32e-05	0.0288
558	MA0137.3	STAT1	MA0137.3	3.42e-05	0.0296
559	MA1506.1	HOXD10	MA1506.1	3.64e-05	0.0315
560	MA1599.1	ZNF682	MA1599.1	3.69e-05	0.032
561	MA0058.3	MAX	MA0058.3	3.77e-05	0.0327
562	MA1608.1	Isl1	MA1608.1	3.84e-05	0.0333
401	MA1710.1 (ZNF257)	STREME-14	14-TCTCCTGCCTCARC	1.25e-08	0.0344
563	MA0466.3	CEBPB	MA0466.3	4.05e-05	0.0351
564	MA1993.1	Neurod2	MA1993.1	4.48e-05	0.0388
172	15-CTGAACA	STREME-15	15-CTGAACA	1.13e-15	0.0389
565	MA1997.1	Olig2	MA1997.1	4.59e-05	0.0398
566	MA1937.1	ERF::HOXB13	MA1937.1	4.95e-05	0.0429
567	MA0510.2	RFX5	MA0510.2	5.12e-05	0.0444
40	MA0676.1 (Nr2e1)	STREME-16	16-AACAGBCA	5.29e-41	0.045
568	MA0161.2	NFIC	MA0161.2	5.36e-05	0.0465
569	MA0832.1	Tcf21	MA0832.1	5.64e-05	0.0489
67	MA0592.3 (ESRRA)	STREME-17	17-AGGTCACA	2.49e-25	0.0581
104	MA1653.1 (ZNF148)	STREME-18	18-CMTCCCC	3.31e-20	0.0627
58	MA1632.1 (ATF2)	STREME-19	19-ACCTCAT	1.13e-29	0.071

EAR_close_200xstreme %>% 
  dplyr::select(RANK,SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
  arrange(.,EVALUE) %>% 
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  # dplyr::filter(., EVALUE<0.05) %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs in EAR close 200bp") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "500px")

Enriched motifs in EAR close 200bp
RANK	SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
1	MA1988.1	Atf3	MA1988.1	5.76e-79	4.97e-76
2	MA0099.3	FOS::JUN	MA0099.3	7.68e-78	6.63e-75
3	MA1130.1	FOSL2::JUN	MA1130.1	2.59e-76	2.24e-73
4	MA1634.1	BATF	MA1634.1	1.33e-75	1.15e-72
5	MA0478.1	FOSL2	MA0478.1	6.12e-74	5.27e-71
6	MA0476.1	FOS	MA0476.1	8.67e-73	7.48e-70
7	MA0462.2	BATF::JUN	MA0462.2	2.17e-71	1.87e-68
8	MA1928.1	BNC2	MA1928.1	4.56e-71	3.93e-68
9	MA1633.2	BACH1	MA1633.2	4.39e-68	3.78e-65
10	MA1137.1	FOSL1::JUNB	MA1137.1	1.32e-67	1.14e-64
11	MA0655.1	JDP2	MA0655.1	3.48e-64	3e-61
12	MA1138.1	FOSL2::JUNB	MA1138.1	4.11e-63	3.54e-60
13	MA1134.1	FOS::JUNB	MA1134.1	3.79e-62	3.27e-59
345	MA1125.1 (ZNF384)	MEME-1	AAAAAAAAAAAAAAW	0.000107	5.2e-59
14	MA0841.1	NFE2	MA0841.1	1.35e-61	1.16e-58
15	MA1135.1	FOSB::JUNB	MA1135.1	5.79e-61	4.99e-58
16	MA1144.1	FOSL2::JUND	MA1144.1	6.98e-60	6.02e-57
18	MA1101.2	BACH2	MA1101.2	2.66e-58	2.29e-55
19	MA1141.1	FOS::JUND	MA1141.1	9.51e-58	8.2e-55
21	MA1128.1	FOSL1::JUN	MA1128.1	1.2e-55	1.03e-52
22	MA0766.2	GATA5	MA0766.2	1.05e-52	9.06e-50
23	MA0501.1	MAF::NFE2	MA0501.1	1.17e-52	1.01e-49
24	MA0835.2	BATF3	MA0835.2	2.69e-52	2.32e-49
348	MA1596.1 (ZNF460)	MEME-2	GGGAGGVDGRGGHDG	0.103	3e-47
26	MA1142.1	FOSL1::JUND	MA1142.1	2.07e-48	1.78e-45
27	MA0491.2	JUND	MA0491.2	9.76e-48	8.41e-45
28	MA0489.2	Jun	MA0489.2	3.48e-46	3e-43
29	MA0676.1	Nr2e1	MA0676.1	5.04e-46	4.35e-43
30	MA0477.2	FOSL1	MA0477.2	1.82e-45	1.57e-42
31	MA0490.2	JUNB	MA0490.2	1.6e-44	1.38e-41
32	MA0150.2	Nfe2l2	MA0150.2	2.85e-44	2.46e-41
33	MA0790.1	POU4F1	MA0790.1	2.93e-43	2.53e-40
34	MA0089.2	MAFG::NFE2L1	MA0089.2	1.08e-42	9.35e-40
35	MA1132.1	JUN::JUNB	MA1132.1	9.99e-41	8.61e-38
36	MA0496.3	MAFK	MA0496.3	3.04e-40	2.62e-37
38	MA0032.2	FOXC1	MA0032.2	5.27e-38	4.54e-35
39	MA0726.1	VSX2	MA0726.1	8.15e-38	7.02e-35
40	MA0792.1	POU5F1B	MA0792.1	1.1e-37	9.49e-35
41	MA0789.1	POU3F4	MA0789.1	2.5e-37	2.16e-34
43	MA0845.1	FOXB1	MA0845.1	4.79e-37	4.13e-34
44	MA0084.1	SRY	MA0084.1	9.84e-37	8.48e-34
45	MA0886.1	EMX2	MA0886.1	5.13e-36	4.43e-33
46	MA1104.2	GATA6	MA1104.2	7.95e-36	6.85e-33
47	MA0899.1	HOXA10	MA0899.1	1.31e-35	1.13e-32
48	MA0035.4	GATA1	MA0035.4	4.34e-35	3.74e-32
49	MA0793.1	POU6F2	MA0793.1	7.99e-35	6.89e-32
50	MA0791.1	POU4F3	MA0791.1	9.91e-35	8.54e-32
51	MA0037.4	Gata3	MA0037.4	2.98e-34	2.57e-31
52	MA1963.1	SATB1	MA1963.1	1.22e-33	1.05e-30
53	MA0675.1	NKX6-2	MA0675.1	1.38e-33	1.19e-30
54	MA0902.2	HOXB2	MA0902.2	1.71e-33	1.47e-30
55	MA0725.1	VSX1	MA0725.1	1.86e-33	1.61e-30
56	MA0704.1	Lhx4	MA0704.1	4.57e-33	3.94e-30
57	MA1639.1	MEIS1	MA1639.1	6.17e-33	5.31e-30
58	MA1481.1	DRGX	MA1481.1	1.85e-32	1.59e-29
59	MA0681.2	PHOX2B	MA0681.2	7.7e-32	6.64e-29
60	MA1530.1	NKX6-3	MA1530.1	8.12e-32	7e-29
61	MA0846.1	FOXC2	MA0846.1	8.18e-32	7.05e-29
62	MA0901.2	HOXB13	MA0901.2	1.29e-31	1.11e-28
63	MA0716.1	PRRX1	MA0716.1	2.6e-31	2.24e-28
64	MA0498.2	MEIS1	MA0498.2	2.72e-31	2.34e-28
65	MA0680.2	Pax7	MA0680.2	6.48e-31	5.59e-28
66	MA0630.1	SHOX	MA0630.1	7.29e-31	6.29e-28
67	MA1563.2	SOX18	MA1563.2	7.48e-31	6.45e-28
68	MA1113.2	PBX2	MA1113.2	7.85e-31	6.76e-28
69	MA0720.1	Shox2	MA0720.1	1.86e-30	1.6e-27
70	MA0723.2	VAX2	MA0723.2	2.38e-30	2.06e-27
71	MA1640.1	MEIS2	MA1640.1	2.81e-30	2.42e-27
72	MA0027.2	EN1	MA0027.2	7.06e-30	6.09e-27
73	MA0707.2	MNX1	MA0707.2	7.48e-30	6.45e-27
74	MA0627.2	POU2F3	MA0627.2	1.31e-29	1.13e-26
75	MA0052.4	MEF2A	MA0052.4	1.72e-29	1.49e-26
76	MA0601.1	Arid3b	MA0601.1	2.64e-29	2.27e-26
77	MA0788.1	POU3F3	MA0788.1	4e-29	3.45e-26
78	MA1480.1	DPRX	MA1480.1	4.03e-29	3.47e-26
79	MA0713.1	PHOX2A	MA0713.1	6.93e-29	5.98e-26
80	MA0724.1	VENTX	MA0724.1	1.05e-28	9.07e-26
81	MA1549.1	POU6F1	MA1549.1	1.1e-28	9.49e-26
82	MA0036.3	GATA2	MA0036.3	1.39e-28	1.19e-25
83	MA0650.3	Hoxa13	MA0650.3	2.09e-28	1.8e-25
84	MA1970.1	TRPS1	MA1970.1	4.14e-28	3.57e-25
85	MA0722.1	VAX1	MA0722.1	4.97e-28	4.28e-25
86	MA0785.1	POU2F1	MA0785.1	6.68e-28	5.75e-25
87	MA1471.1	BARX2	MA1471.1	7.28e-28	6.28e-25
88	MA1476.2	Dlx5	MA1476.2	9.51e-28	8.2e-25
89	MA1487.2	FOXE1	MA1487.2	1.59e-27	1.37e-24
90	MA0890.1	GBX2	MA0890.1	1.68e-27	1.45e-24
91	MA0482.2	GATA4	MA0482.2	2.26e-27	1.95e-24
92	MA0666.2	MSX1	MA0666.2	2.67e-27	2.3e-24
93	MA1502.1	HOXB8	MA1502.1	3.08e-27	2.66e-24
94	MA0708.2	MSX2	MA0708.2	5.31e-27	4.58e-24
95	MA0495.3	MAFF	MA0495.3	5.64e-27	4.86e-24
96	MA0879.2	DLX1	MA0879.2	5.67e-27	4.88e-24
98	MA0125.1	Nobox	MA0125.1	9.96e-27	8.59e-24
99	MA0654.1	ISX	MA0654.1	1.79e-26	1.54e-23
100	MA0523.1	TCF7L2	MA0523.1	2.11e-26	1.82e-23
101	MA1152.1	SOX15	MA1152.1	2.89e-26	2.49e-23
102	MA0782.2	PKNOX1	MA0782.2	3.31e-26	2.85e-23
103	MA0881.1	Dlx4	MA0881.1	4.17e-26	3.6e-23
104	MA0644.2	ESX1	MA0644.2	8.15e-26	7.03e-23
105	MA0628.1	POU6F1	MA0628.1	8.69e-26	7.49e-23
106	MA1978.1	ZNF354A	MA1978.1	1.72e-25	1.48e-22
107	MA0140.2	GATA1::TAL1	MA0140.2	1.79e-25	1.55e-22
108	MA0868.2	SOX8	MA0868.2	2.23e-25	1.92e-22
109	MA1495.1	HOXA1	MA1495.1	2.26e-25	1.95e-22
110	MA0876.1	BSX	MA0876.1	2.36e-25	2.04e-22
111	MA0025.2	NFIL3	MA0025.2	2.47e-25	2.13e-22
112	MA0709.1	Msx3	MA0709.1	3.02e-25	2.6e-22
113	MA1607.1	Foxl2	MA1607.1	3.65e-25	3.15e-22
114	MA0041.2	FOXD3	MA0041.2	4.29e-25	3.7e-22
115	MA0679.2	ONECUT1	MA0679.2	4.31e-25	3.72e-22
116	MA0885.2	Dlx2	MA0885.2	6.01e-25	5.18e-22
117	MA0842.2	NRL	MA0842.2	6.82e-25	5.88e-22
118	MA0031.1	FOXD1	MA0031.1	7.32e-25	6.31e-22
119	MA0721.1	UNCX	MA0721.1	8.02e-25	6.91e-22
120	MA0880.1	Dlx3	MA0880.1	8.28e-25	7.14e-22
121	MA0875.1	BARX1	MA0875.1	8.42e-25	7.26e-22
122	MA0710.1	NOTO	MA0710.1	1.01e-24	8.66e-22
123	MA0882.1	DLX6	MA0882.1	1.07e-24	9.18e-22
124	MA0705.1	Lhx8	MA0705.1	1.12e-24	9.67e-22
125	MA1606.1	Foxf1	MA1606.1	1.51e-24	1.3e-21
126	MA0602.1	Arid5a	MA0602.1	1.59e-24	1.37e-21
127	MA0909.3	Hoxd13	MA0909.3	1.88e-24	1.62e-21
128	MA0142.1	Pou5f1::Sox2	MA0142.1	2.79e-24	2.41e-21
325	MA1973.1 (ZKSCAN3)	MEME-3	TGTYGCCCAGGCTGG	9.74e-06	2.8e-21
129	MA1519.1	LHX5	MA1519.1	3.88e-24	3.34e-21
130	MA0047.3	FOXA2	MA0047.3	5.88e-24	5.07e-21
131	MA0700.2	LHX2	MA0700.2	6.7e-24	5.77e-21
132	MA0648.1	GSC	MA0648.1	8.84e-24	7.62e-21
133	MA0481.3	FOXP1	MA0481.3	1.18e-23	1.02e-20
134	MA0682.2	PITX1	MA0682.2	1.63e-23	1.41e-20
135	MA0889.1	GBX1	MA0889.1	2.45e-23	2.11e-20
136	MA0910.2	HOXD8	MA0910.2	3.37e-23	2.9e-20
137	MA0903.1	HOXB3	MA0903.1	3.84e-23	3.31e-20
138	MA0635.1	BARHL2	MA0635.1	4.66e-23	4.01e-20
139	MA0674.1	NKX6-1	MA0674.1	5.88e-23	5.07e-20
140	MA0634.1	ALX3	MA0634.1	6.61e-23	5.7e-20
142	MA0787.1	POU3F2	MA0787.1	1.29e-22	1.11e-19
143	MA0658.1	LHX6	MA0658.1	1.34e-22	1.16e-19
144	MA0706.1	MEOX2	MA0706.1	1.77e-22	1.52e-19
145	MA0497.1	MEF2C	MA0497.1	3.03e-22	2.61e-19
346	MA0682.2 (PITX1)	MEME-4	WGCTGGGATTACAGG	0.000961	4.2e-19
146	MA0042.2	FOXI1	MA0042.2	5.8e-22	5e-19
147	MA0077.1	SOX9	MA0077.1	7.04e-22	6.07e-19
148	MA0612.2	EMX1	MA0612.2	1.33e-21	1.15e-18
149	MA1115.1	POU5F1	MA1115.1	1.67e-21	1.44e-18
151	MA0465.2	CDX2	MA0465.2	2.63e-21	2.27e-18
153	MA1603.1	Dmrt1	MA1603.1	3.18e-21	2.74e-18
154	MA0148.4	FOXA1	MA0148.4	3.72e-21	3.21e-18
155	MA0786.1	POU3F1	MA0786.1	4.04e-21	3.48e-18
156	MA1636.1	CEBPG	MA1636.1	4.56e-21	3.93e-18
157	MA0718.1	RAX	MA0718.1	9.15e-21	7.88e-18
158	MA0848.1	FOXO4	MA0848.1	9.71e-21	8.37e-18
159	MA0033.2	FOXL1	MA0033.2	1.54e-20	1.33e-17
160	MA0904.2	HOXB5	MA0904.2	1.87e-20	1.61e-17
161	MA1657.1	ZNF652	MA1657.1	3.73e-20	3.21e-17
162	MA0144.2	STAT3	MA0144.2	4.25e-20	3.66e-17
163	MA0018.4	CREB1	MA0018.4	5.76e-20	4.97e-17
164	MA0908.1	HOXD11	MA0908.1	6.06e-20	5.22e-17
165	MA0775.1	MEIS3	MA0775.1	8.53e-20	7.35e-17
166	MA0905.1	HOXC10	MA0905.1	2.07e-19	1.78e-16
167	MA1103.2	FOXK2	MA1103.2	2.2e-19	1.9e-16
168	MA0887.1	EVX1	MA0887.1	2.46e-19	2.12e-16
169	MA0070.1	PBX1	MA0070.1	2.94e-19	2.54e-16
170	MA0914.1	ISL2	MA0914.1	3.28e-19	2.83e-16
171	MA0143.4	SOX2	MA0143.4	3.51e-19	3.02e-16
172	MA0847.3	FOXD2	MA0847.3	3.54e-19	3.05e-16
173	MA1114.1	PBX3	MA1114.1	5.69e-19	4.91e-16
174	MA1498.2	HOXA7	MA1498.2	7.11e-19	6.13e-16
175	MA0717.1	RAX2	MA0717.1	8.84e-19	7.62e-16
176	MA1505.1	HOXC8	MA1505.1	1.03e-18	8.87e-16
177	MA0662.1	MIXL1	MA0662.1	1.18e-18	1.01e-15
178	MA0894.1	HESX1	MA0894.1	1.66e-18	1.43e-15
179	MA0117.2	Mafb	MA0117.2	2e-18	1.72e-15
180	MA0442.2	SOX10	MA0442.2	2.13e-18	1.83e-15
181	MA0892.1	GSX1	MA0892.1	4.25e-18	3.66e-15
182	MA0701.2	LHX9	MA0701.2	5.01e-18	4.32e-15
183	MA1120.1	SOX13	MA1120.1	5.15e-18	4.44e-15
184	MA0492.1	JUND	MA0492.1	5.25e-18	4.53e-15
185	MA1632.1	ATF2	MA1632.1	6.18e-18	5.33e-15
186	MA0068.2	PAX4	MA0068.2	9.35e-18	8.06e-15
187	MA1960.1	MGA::EVX1	MA1960.1	1.16e-17	9.98e-15
188	MA0891.1	GSC2	MA0891.1	2.01e-17	1.74e-14
189	MA1683.1	FOXA3	MA1683.1	2.18e-17	1.88e-14
190	MA0774.1	MEIS2	MA0774.1	3.03e-17	2.61e-14
191	MA0699.1	LBX2	MA0699.1	3.12e-17	2.69e-14
192	MA0642.2	EN2	MA0642.2	4.21e-17	3.63e-14
193	MA0151.1	Arid3a	MA0151.1	6.05e-17	5.21e-14
194	MA0124.2	Nkx3-1	MA0124.2	1.15e-16	9.92e-14
195	MA0895.1	HMBOX1	MA0895.1	1.21e-16	1.04e-13
196	MA1463.1	ARGFX	MA1463.1	1.49e-16	1.28e-13
197	MA0488.1	JUN	MA0488.1	2.37e-16	2.04e-13
198	MA0108.2	TBP	MA0108.2	3.04e-16	2.62e-13
199	MA0122.3	Nkx3-2	MA0122.3	3.06e-16	2.64e-13
200	MA1497.1	HOXA6	MA1497.1	3.61e-16	3.11e-13
201	MA0769.2	TCF7	MA0769.2	6.71e-16	5.78e-13
202	MA0797.1	TGIF2	MA0797.1	1.61e-15	1.39e-12
203	MA0102.4	CEBPA	MA0102.4	1.61e-15	1.39e-12
205	MA0711.1	OTX1	MA0711.1	4.57e-15	3.94e-12
206	MA0829.2	SREBF1	MA0829.2	5.73e-15	4.94e-12
207	MA1720.1	ZNF85	MA1720.1	6.66e-15	5.74e-12
208	MA1489.1	FOXN3	MA1489.1	6.73e-15	5.8e-12
209	MA0157.3	Foxo3	MA0157.3	6.91e-15	5.96e-12
210	MA0851.1	Foxj3	MA0851.1	1.39e-14	1.2e-11
211	MA0712.2	OTX2	MA0712.2	1.53e-14	1.32e-11
212	MA1499.1	HOXB4	MA1499.1	1.63e-14	1.4e-11
213	MA0913.2	HOXD9	MA0913.2	1.98e-14	1.7e-11
214	MA0833.2	ATF4	MA0833.2	2.18e-14	1.88e-11
215	MA0661.1	MEOX1	MA0661.1	4.08e-14	3.52e-11
216	MA0912.2	HOXD3	MA0912.2	4.79e-14	4.13e-11
217	MA0063.2	NKX2-5	MA0063.2	6.56e-14	5.65e-11
218	MA1124.1	ZNF24	MA1124.1	7.57e-14	6.52e-11
219	MA0596.1	SREBF2	MA0596.1	8.72e-14	7.52e-11
220	MA0659.3	Mafg	MA0659.3	9.98e-14	8.6e-11
221	MA0911.1	Hoxa11	MA0911.1	1.04e-13	8.98e-11
222	MA0029.1	Mecom	MA0029.1	1.24e-13	1.06e-10
223	MA0900.2	HOXA2	MA0900.2	1.75e-13	1.51e-10
224	MA0611.2	Dux	MA0611.2	1.99e-13	1.71e-10
225	MA1504.1	HOXC4	MA1504.1	2.59e-13	2.24e-10
226	MA1518.2	Lhx1	MA1518.2	2.78e-13	2.4e-10
227	MA1110.2	Nr1H4	MA1110.2	2.78e-13	2.4e-10
228	MA0867.2	SOX4	MA0867.2	4.35e-13	3.75e-10
229	MA0805.1	TBX1	MA0805.1	4.68e-13	4.03e-10
230	MA1623.1	Stat2	MA1623.1	9.21e-13	7.94e-10
231	MA0888.1	EVX2	MA0888.1	9.28e-13	8e-10
232	MA0483.1	Gfi1B	MA0483.1	9.97e-13	8.59e-10
233	MA1608.1	Isl1	MA1608.1	1.13e-12	9.73e-10
234	MA0050.3	Irf1	MA0050.3	1.25e-12	1.08e-09
235	MA1479.1	DMRTC2	MA1479.1	1.29e-12	1.11e-09
236	MA0613.1	FOXG1	MA0613.1	1.68e-12	1.45e-09
237	MA0768.2	Lef1	MA0768.2	1.82e-12	1.57e-09
238	MA0715.1	PROP1	MA0715.1	2.14e-12	1.84e-09
240	MA0898.1	Hmx3	MA0898.1	4.47e-12	3.85e-09
241	MA0153.2	HNF1B	MA0153.2	5.13e-12	4.42e-09
242	MA0624.2	Nfatc1	MA0624.2	5.18e-12	4.46e-09
243	MA0714.1	PITX3	MA0714.1	5.24e-12	4.52e-09
244	MA1991.1	Hnf1A	MA1991.1	8.04e-12	6.93e-09
245	MA1593.1	ZNF317	MA1593.1	1.29e-11	1.11e-08
246	MA0095.3	Yy1	MA0095.3	1.36e-11	1.17e-08
248	MA1571.1	TGIF2LX	MA1571.1	1.62e-11	1.39e-08
249	MA0606.2	Nfat5	MA0606.2	1.65e-11	1.42e-08
250	MA0691.1	TFAP4	MA0691.1	1.69e-11	1.46e-08
251	MA0480.2	Foxo1	MA0480.2	1.97e-11	1.69e-08
252	MA1501.1	HOXB7	MA1501.1	2.13e-11	1.83e-08
253	MA0850.1	FOXP3	MA0850.1	2.71e-11	2.34e-08
254	MA0078.2	Sox17	MA0078.2	2.8e-11	2.41e-08
255	MA1131.1	FOSL2::JUN	MA1131.1	3.55e-11	3.06e-08
256	MA1496.1	HOXA4	MA1496.1	4.5e-11	3.88e-08
257	MA1643.1	NFIB	MA1643.1	8.77e-11	7.56e-08
258	MA1127.1	FOSB::JUN	MA1127.1	9.42e-11	8.12e-08
259	MA0755.1	CUX2	MA0755.1	9.63e-11	8.31e-08
260	MA0090.3	TEAD1	MA0090.3	9.65e-11	8.32e-08
261	MA0803.1	TBX15	MA0803.1	1.06e-10	9.1e-08
262	MA0119.1	NFIC::TLX1	MA0119.1	1.08e-10	9.31e-08
20	MA1928.1 (BNC2)	STREME-1	1-VTGASTCAB	2.84e-56	9.51e-08
263	MA0071.1	RORA	MA0071.1	1.17e-10	1.01e-07
17	MA0037.4 (Gata3)	STREME-2	2-CAGATAA	1.53e-59	1.46e-07
264	MA1500.1	HOXB6	MA1500.1	2.15e-10	1.86e-07
265	MA0017.2	NR2F1	MA0017.2	2.25e-10	1.94e-07
266	MA1527.1	NFIC	MA1527.1	2.63e-10	2.27e-07
267	MA1139.1	FOSL2::JUNB	MA1139.1	3.28e-10	2.83e-07
268	MA0046.2	HNF1A	MA0046.2	3.88e-10	3.34e-07
269	MA0618.1	LBX1	MA0618.1	4.19e-10	3.62e-07
270	MA0893.2	GSX2	MA0893.2	7.14e-10	6.15e-07
271	MA0614.1	Foxj2	MA0614.1	1.01e-09	8.75e-07
272	MA0631.1	Six3	MA0631.1	1.3e-09	1.12e-06
37	MA1991.1 (Hnf1A)	STREME-3	3-ATCAAA	3.24e-38	1.27e-06
273	MA0591.1	Bach1::Mafk	MA0591.1	1.48e-09	1.27e-06
274	MA1119.1	SIX2	MA1119.1	2.16e-09	1.86e-06
275	MA1112.2	NR4A1	MA1112.2	2.33e-09	2.01e-06
276	MA1105.2	GRHL2	MA1105.2	2.47e-09	2.13e-06
278	MA1528.1	NFIX	MA1528.1	4.03e-09	3.47e-06
279	MA1118.1	SIX1	MA1118.1	7.73e-09	6.66e-06
280	MA0896.1	Hmx1	MA0896.1	9.92e-09	8.55e-06
281	MA0689.1	TBX20	MA0689.1	2.06e-08	1.78e-05
282	MA0093.3	USF1	MA0093.3	4.41e-08	3.8e-05
283	MA1111.1	NR2F2	MA1111.1	4.74e-08	4.08e-05
284	MA0152.2	Nfatc2	MA0152.2	5.3e-08	4.57e-05
285	MA0849.1	FOXO6	MA0849.1	5.75e-08	4.95e-05
286	MA0673.1	NKX2-8	MA0673.1	5.96e-08	5.13e-05
287	MA0468.1	DUX4	MA0468.1	6.85e-08	5.9e-05
288	MA1145.1	FOSL2::JUND	MA1145.1	6.91e-08	5.96e-05
289	MA1143.1	FOSL1::JUND	MA1143.1	7.09e-08	6.11e-05
290	MA0877.3	BARHL1	MA0877.3	1.04e-07	8.95e-05
291	MA0836.2	CEBPD	MA0836.2	1.25e-07	0.000108
292	MA0854.1	Alx1	MA0854.1	1.38e-07	0.000119
294	MA1709.1	ZIM3	MA1709.1	1.6e-07	0.000138
295	MA1562.1	SOX14	MA1562.1	1.61e-07	0.000139
296	MA0038.2	GFI1	MA0038.2	1.75e-07	0.000151
297	MA1126.1	FOS::JUN	MA1126.1	2.52e-07	0.000218
298	MA1567.2	Tbx6	MA1567.2	3.97e-07	0.000342
299	MA0807.1	TBX5	MA0807.1	4.91e-07	0.000423
300	MA0629.1	Rhox11	MA0629.1	5.44e-07	0.000469
301	MA1707.1	DMRTA1	MA1707.1	6.38e-07	0.00055
239	4-CAGTGAGCTG	STREME-4	4-CAGTGAGCTG	2.31e-12	0.000572
302	MA0853.1	Alx4	MA0853.1	7.61e-07	0.000656
303	MA1644.1	NFYC	MA1644.1	8.44e-07	0.000728
304	MA1478.1	DMRTA2	MA1478.1	9.72e-07	0.000837
314	MA1627.1 (Wt1)	MEME-5	CCCCWCCCCCMMNCC	4.21e-06	0.00089
305	MA0883.1	Dmbx1	MA0883.1	1.11e-06	0.000957
306	MA0783.1	PKNOX2	MA0783.1	1.13e-06	0.000978
307	MA0087.2	Sox5	MA0087.2	1.15e-06	0.000992
308	MA0831.3	TFE3	MA0831.3	1.38e-06	0.00119
25	MA0498.2 (MEIS1)	STREME-5	5-CTGWCAG	2.54e-51	0.00153
309	MA0809.2	TEAD4	MA0809.2	2.22e-06	0.00191
310	MA0698.1	ZBTB18	MA0698.1	2.59e-06	0.00223
311	MA2003.1	NKX2-4	MA2003.1	2.6e-06	0.00224
312	MA0595.1	SREBF1	MA0595.1	2.66e-06	0.00229
313	MA0092.1	Hand1::Tcf3	MA0092.1	2.83e-06	0.00244
315	MA0693.3	Vdr	MA0693.3	4.56e-06	0.00393
316	MA0620.3	MITF	MA0620.3	4.87e-06	0.0042
317	MA1150.1	RORB	MA1150.1	5.78e-06	0.00498
141	6-AGAAAA	STREME-6	6-AGAAAA	1.07e-22	0.00522
318	MA1618.1	Ptf1a	MA1618.1	6.12e-06	0.00528
319	MA0780.1	PAX3	MA0780.1	6.23e-06	0.00537
204	MA1627.1 (Wt1)	STREME-7	7-CCTCCCCCA	1.89e-15	0.00542
320	MA0141.3	ESRRB	MA0141.3	6.98e-06	0.00602
321	MA0840.1	Creb5	MA0840.1	7.46e-06	0.00643
322	MA0684.2	RUNX3	MA0684.2	8.09e-06	0.00697
323	MA1962.1	POU2F1::SOX2	MA1962.1	8.72e-06	0.00751
324	MA0852.2	FOXK1	MA0852.2	9.22e-06	0.00795
326	MA0672.1	NKX2-3	MA0672.1	1.06e-05	0.00911
277	8-TRATYA	STREME-8	8-TRATYA	2.97e-09	0.00982
328	MA1974.1	ZNF211	MA1974.1	1.3e-05	0.0112
329	MA0514.2	Sox3	MA0514.2	1.31e-05	0.0113
330	MA0610.1	DMRT3	MA0610.1	1.36e-05	0.0118
331	MA0599.1	KLF5	MA0599.1	1.49e-05	0.0128
332	MA1507.1	HOXD4	MA1507.1	1.55e-05	0.0134
333	MA0806.1	TBX4	MA0806.1	1.69e-05	0.0145
334	MA0467.2	Crx	MA0467.2	2.18e-05	0.0188
335	MA0656.1	JDP2	MA0656.1	2.21e-05	0.019
336	MA0132.2	PDX1	MA0132.2	2.26e-05	0.0195
337	MA0796.1	TGIF1	MA0796.1	2.78e-05	0.0239
338	MA0623.2	NEUROG1	MA0623.2	3e-05	0.0259
339	MA1980.1	ZNF418	MA1980.1	3.21e-05	0.0277
327	MA1125.1 (ZNF384)	MEME-6	YCTGTCTCAAAAMAA	1.28e-05	0.029
340	MA0688.1	TBX2	MA0688.1	3.43e-05	0.0295
341	MA1645.1	NKX2-2	MA1645.1	3.51e-05	0.0303
247	9-AATGTA	STREME-9	9-AATGTA	1.54e-11	0.0319
293	MA0592.3 (ESRRA)	STREME-10	10-AGGTCA	1.43e-07	0.0319
347	MA1715.1 (ZNF707)	STREME-11	11-GCCCAGCTCCTGA	0.0711	0.0335
42	MA1633.2 (BACH1)	STREME-12	12-AGTCAT	3.45e-37	0.037
342	MA1570.1	TFAP4	MA1570.1	4.71e-05	0.0406
343	MA0802.1	TBR1	MA0802.1	4.76e-05	0.0411
344	MA1503.1	HOXB9	MA1503.1	5.28e-05	0.0455
97	MA1632.1 (ATF2)	STREME-13	13-ATGAGGTR	6.8e-27	0.0712
152	14-AAGATG	STREME-14	14-AAGATG	2.71e-21	0.0738
150	MA1657.1 (ZNF652)	STREME-15	15-AGAGTT	2.54e-21	0.128

ESR lists

ESR_open_xstreme %>% 
 dplyr::select(RANK,SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
   arrange(.,EVALUE) %>% 
   dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  # dplyr::filter(., EVALUE<0.05) %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs in ESR open") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "800px")

Enriched motifs in ESR open
RANK	SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
6	MA0490.2	JUNB	MA0490.2	4.45e-102	3.85e-99
11	MA0491.2	JUND	MA0491.2	9.18e-95	7.95e-92
12	MA1130.1	FOSL2::JUN	MA1130.1	3.34e-92	2.89e-89
14	MA1142.1	FOSL1::JUND	MA1142.1	1.32e-89	1.14e-86
15	MA0099.3	FOS::JUN	MA0099.3	4.73e-89	4.09e-86
17	MA0477.2	FOSL1	MA0477.2	2.64e-87	2.29e-84
18	MA1138.1	FOSL2::JUNB	MA1138.1	6.32e-87	5.47e-84
19	MA1141.1	FOS::JUND	MA1141.1	1.41e-85	1.22e-82
20	MA1137.1	FOSL1::JUNB	MA1137.1	2.54e-85	2.2e-82
21	MA1144.1	FOSL2::JUND	MA1144.1	3.81e-85	3.3e-82
23	MA1135.1	FOSB::JUNB	MA1135.1	2.38e-84	2.06e-81
24	MA1988.1	Atf3	MA1988.1	3.05e-84	2.64e-81
25	MA0655.1	JDP2	MA0655.1	1.01e-82	8.78e-80
27	MA1134.1	FOS::JUNB	MA1134.1	1.18e-79	1.02e-76
28	MA0841.1	NFE2	MA0841.1	1.84e-79	1.59e-76
29	MA1633.2	BACH1	MA1633.2	5.98e-79	5.18e-76
30	MA0476.1	FOS	MA0476.1	1.41e-77	1.22e-74
31	MA1634.1	BATF	MA1634.1	1.49e-76	1.29e-73
32	MA0835.2	BATF3	MA0835.2	1.76e-75	1.52e-72
34	MA0462.2	BATF::JUN	MA0462.2	1.45e-74	1.26e-71
36	MA0489.2	Jun	MA0489.2	2.18e-71	1.89e-68
37	MA1101.2	BACH2	MA1101.2	1.26e-69	1.09e-66
38	MA0861.1	TP73	MA0861.1	4.55e-68	3.94e-65
39	MA1155.1	ZSCAN4	MA1155.1	9.54e-67	8.26e-64
41	MA0106.3	TP53	MA0106.3	2.63e-62	2.28e-59
45	MA1128.1	FOSL1::JUN	MA1128.1	2.24e-53	1.94e-50
47	MA1132.1	JUN::JUNB	MA1132.1	1.75e-50	1.52e-47
100	MA1125.1 (ZNF384)	MEME-1	TWTTTTTTTHTTTTT	0.186	4.3e-44
50	MA0525.2	TP63	MA0525.2	4.56e-38	3.95e-35
13	ACACACACACACACA	MEME-2	ACACACACACACACA	7.04e-91	4.1e-30
51	MA1108.2	MXI1	MA1108.2	1.46e-25	1.27e-22
98	MA1547.2 (PITX2)	MEME-3	WGCTGGGATTACAGG	0.000211	1.5e-22
52	MA0626.1	Npas2	MA0626.1	2.64e-24	2.29e-21
53	MA0006.1	Ahr::Arnt	MA0006.1	9.17e-24	7.95e-21
54	MA0819.2	CLOCK	MA0819.2	3.84e-21	3.32e-18
55	MA0089.2	MAFG::NFE2L1	MA0089.2	5.88e-21	5.09e-18
56	MA0622.1	Mlxip	MA0622.1	6.84e-21	5.92e-18
57	MA0478.1	FOSL2	MA0478.1	1.4e-18	1.21e-15
58	MA0817.1	BHLHE23	MA0817.1	1.61e-17	1.4e-14
59	MA1928.1	BNC2	MA1928.1	9.49e-16	8.22e-13
60	MA0073.1	RREB1	MA0073.1	1.5e-15	1.3e-12
61	MA0623.2	NEUROG1	MA0623.2	2.75e-15	2.39e-12
62	MA0496.3	MAFK	MA0496.3	3.55e-15	3.07e-12
63	MA0004.1	Arnt	MA0004.1	2.66e-14	2.3e-11
5	MA1107.2 (KLF9)	STREME-1	1-CACACGCACAC	1.13e-103	2.47e-11
64	MA1718.1	ZNF8	MA1718.1	3.58e-14	3.1e-11
65	MA1107.2	KLF9	MA1107.2	3.18e-13	2.76e-10
66	MA1560.1	SOHLH2	MA1560.1	1.51e-12	1.31e-09
67	MA1974.1	ZNF211	MA1974.1	2.11e-12	1.83e-09
68	MA0823.1	HEY1	MA0823.1	2.37e-12	2.05e-09
69	MA0058.3	MAX	MA0058.3	2.8e-12	2.42e-09
70	MA0825.1	MNT	MA0825.1	2.83e-12	2.45e-09
2	2-ACACACATACAC	STREME-2	2-ACACACATACAC	5.97e-115	1.31e-08
1	3-CATGCACACACA	STREME-3	3-CATGCACACACA	2.51e-115	1.35e-08
40	4-CACACAYAYACACAC	STREME-4	4-CACACAYAYACACAC	1.69e-63	5.94e-08
71	MA0818.2	BHLHE22	MA0818.2	1.35e-10	1.17e-07
16	5-ACACACACCACAC	STREME-5	5-ACACACACCACAC	1.49e-87	2.07e-07
99	MA1973.1 (ZKSCAN3)	MEME-4	TGTTGCCCAGGCTGG	0.0041	2.2e-07
8	MA1990.1 (Gli1)	STREME-6	6-CACACACCACACACA	7.32e-100	1.08e-06
26	MA1107.2 (KLF9)	STREME-7	7-ACACACACACAC	2.27e-82	5.35e-06
72	MA1602.1	ZSCAN29	MA1602.1	7.62e-09	6.6e-06
73	MA0464.2	BHLHE40	MA0464.2	7.81e-09	6.76e-06
74	MA0501.1	MAF::NFE2	MA0501.1	8.08e-09	7e-06
75	MA0827.1	OLIG3	MA0827.1	2.83e-08	2.45e-05
76	MA0147.3	MYC	MA0147.3	2.92e-08	2.53e-05
77	MA0150.2	Nfe2l2	MA0150.2	5.04e-08	4.37e-05
78	MA0659.3	Mafg	MA0659.3	5.32e-08	4.61e-05
22	MA0491.2 (JUND)	STREME-8	8-NATGASTCATN	1.31e-84	5.98e-05
7	MA1107.2 (KLF9)	STREME-9	9-CACACACACATG	1.98e-100	6.43e-05
79	MA0259.1	ARNT::HIF1A	MA0259.1	8e-08	6.93e-05
80	MA1464.1	ARNT2	MA1464.1	2.1e-07	0.000182
81	MA0052.4	MEF2A	MA0052.4	4.84e-07	0.000419
82	MA0821.2	HES5	MA0821.2	7.8e-07	0.000676
35	MA1718.1 (ZNF8)	STREME-10	10-CAYACACCACA	4.89e-72	0.00093
4	11-CATACACACG	STREME-11	11-CATACACACG	1.49e-110	0.00104
83	MA0678.1	OLIG2	MA0678.1	1.38e-06	0.0012
84	MA0608.1	Creb3l2	MA0608.1	1.47e-06	0.00127
33	MA1155.1 (ZSCAN4)	STREME-12	12-CACACACAG	5.98e-75	0.00227
9	13-CACACACATA	STREME-13	13-CACACACATA	4.8e-99	0.00235
85	MA0507.2	POU2F2	MA0507.2	3.02e-06	0.00262
86	MA0789.1	POU3F4	MA0789.1	3.29e-06	0.00285
87	MA0009.2	TBXT	MA0009.2	3.39e-06	0.00294
88	MA0461.2	Atoh1	MA0461.2	4.66e-06	0.00403
89	MA0472.2	EGR2	MA0472.2	5.01e-06	0.00433
48	MA0259.1 (ARNT::HIF1A)	STREME-14	14-YABACRTGCMY	2.41e-50	0.00578
90	MA0616.2	HES2	MA0616.2	7.38e-06	0.00639
91	MA0649.1	HEY2	MA0649.1	7.68e-06	0.00665
3	15-CATGCCCACAC	STREME-15	15-CATGCCCACAC	6.81e-111	0.00932
10	MA1107.2 (KLF9)	STREME-16	16-CACACACA	1.56e-96	0.0193
49	MA1155.1 (ZSCAN4)	STREME-17	17-ACACAC	2.2e-46	0.0253
92	MA1106.1	HIF1A	MA1106.1	3.07e-05	0.0266
93	MA0497.1	MEF2C	MA0497.1	3.48e-05	0.0301
94	MA0059.1	MAX::MYC	MA0059.1	4.43e-05	0.0384
95	MA0801.1	MGA	MA0801.1	4.73e-05	0.041
96	MA0148.4	FOXA1	MA0148.4	4.77e-05	0.0413
97	MA0698.1	ZBTB18	MA0698.1	5e-05	0.0433
46	18-ACACACA	STREME-18	18-ACACACA	7.08e-53	0.0481
44	19-ACRTGYAC	STREME-19	19-ACRTGYAC	5.15e-56	0.0556
42	MA1108.2 (MXI1)	STREME-20	20-CACACATGTG	4.64e-58	0.832
43	MA1135.1 (FOSB::JUNB)	STREME-21	21-ATGASTCAT	9.62e-57	4.74

ESR_open_200xstreme %>% 
 dplyr::select(RANK,SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
   arrange(.,EVALUE) %>% 
   dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  # dplyr::filter(., EVALUE<0.05) %>% 
  dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  kable(., caption = "Enriched motifs in ESR open, 200bp") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "800px")

Enriched motifs in ESR open, 200bp
RANK	SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
16	MA0490.2	JUNB	MA0490.2	3.44e-109	3e-106
3	GTGTGTGTGTGTGTG	MEME-1	GTGTGTGTGTGTGTG	4.65e-124	5e-101
18	MA0491.2	JUND	MA0491.2	1.66e-100	1.45e-97
19	MA1128.1	FOSL1::JUN	MA1128.1	2.7e-100	2.36e-97
20	MA0099.3	FOS::JUN	MA0099.3	1.43e-99	1.25e-96
22	MA0477.2	FOSL1	MA0477.2	3.12e-98	2.73e-95
23	MA1144.1	FOSL2::JUND	MA1144.1	7.01e-98	6.13e-95
24	MA0655.1	JDP2	MA0655.1	1.4e-95	1.22e-92
25	MA1138.1	FOSL2::JUNB	MA1138.1	1.5e-95	1.31e-92
26	MA1142.1	FOSL1::JUND	MA1142.1	2.53e-94	2.21e-91
27	MA1135.1	FOSB::JUNB	MA1135.1	1.2e-92	1.05e-89
29	MA1137.1	FOSL1::JUNB	MA1137.1	1.57e-89	1.37e-86
30	MA1988.1	Atf3	MA1988.1	7.68e-88	6.71e-85
32	MA1141.1	FOS::JUND	MA1141.1	1.73e-86	1.51e-83
34	MA0476.1	FOS	MA0476.1	1.87e-85	1.63e-82
35	MA1633.2	BACH1	MA1633.2	1.23e-84	1.08e-81
36	MA1130.1	FOSL2::JUN	MA1130.1	6.65e-82	5.81e-79
37	MA0841.1	NFE2	MA0841.1	4.39e-81	3.84e-78
38	MA0835.2	BATF3	MA0835.2	4.69e-79	4.1e-76
39	MA1134.1	FOS::JUNB	MA1134.1	9.62e-79	8.41e-76
40	MA1101.2	BACH2	MA1101.2	2e-74	1.75e-71
41	MA1132.1	JUN::JUNB	MA1132.1	7.45e-73	6.51e-70
42	MA1634.1	BATF	MA1634.1	8.57e-68	7.5e-65
43	MA0489.2	Jun	MA0489.2	3.62e-67	3.16e-64
44	MA1155.1	ZSCAN4	MA1155.1	2e-66	1.75e-63
45	MA0861.1	TP73	MA0861.1	8.68e-66	7.58e-63
46	MA0106.3	TP53	MA0106.3	1.28e-65	1.12e-62
47	MA0462.2	BATF::JUN	MA0462.2	1.39e-65	1.22e-62
48	MA0478.1	FOSL2	MA0478.1	3.93e-64	3.43e-61
126	MA1125.1 (ZNF384)	MEME-2	WWTTTTTKTWTTTTT	0.00125	5.3e-48
17	TGTGTRTGTGT	MEME-3	TGTGTRTGTGT	2.04e-106	4.2e-44
50	MA0073.1	RREB1	MA0073.1	5.61e-42	4.9e-39
51	MA0525.2	TP63	MA0525.2	8.72e-39	7.62e-36
88	MA1547.2 (PITX2)	MEME-4	AAAGTGCTGGGATTA	2.62e-08	1.9e-34
53	MA1108.2	MXI1	MA1108.2	4.61e-35	4.03e-32
55	MA1928.1	BNC2	MA1928.1	3.12e-34	2.73e-31
56	MA0006.1	Ahr::Arnt	MA0006.1	7.06e-34	6.17e-31
95	MA1596.1 (ZNF460)	MEME-6	GGGAGGCYGAGGYRG	1.34e-07	2.5e-27
127	MA1973.1 (ZKSCAN3)	MEME-10	TGTTGCCCAGGCTGG	0.00163	3.9e-24
125	GAGACRGRGTYTCRC	MEME-11	GAGACRGRGTYTCRC	0.000286	2.3e-23
57	MA0089.2	MAFG::NFE2L1	MA0089.2	2.88e-24	2.52e-21
58	MA0819.2	CLOCK	MA0819.2	1.17e-22	1.02e-19
59	MA0623.2	NEUROG1	MA0623.2	1.8e-21	1.57e-18
60	MA1974.1	ZNF211	MA1974.1	2.95e-21	2.58e-18
61	MA0259.1	ARNT::HIF1A	MA0259.1	2e-20	1.75e-17
12	MA1107.2 (KLF9)	MEME-7	GTRTGTGTGTG	1.21e-115	3.1e-17
62	MA1718.1	ZNF8	MA1718.1	1.09e-19	9.49e-17
63	MA0501.1	MAF::NFE2	MA0501.1	1.7e-18	1.49e-15
64	MA0626.1	Npas2	MA0626.1	2.84e-18	2.48e-15
9	TGTGTGTRTGTGTGT	MEME-13	TGTGTGTRTGTGTGT	2.59e-117	8e-15
2	TGTGTGYRTGTGTG	MEME-8	TGTGTGYRTGTGTG	1.63e-128	4e-14
28	MA1107.2 (KLF9)	MEME-9	TGTGTGTGTGTRTG	1.7e-92	6.6e-14
7	MA1107.2 (KLF9)	STREME-1	1-CACACACACACAC	1.04e-118	3.08e-13
33	2-CACACACACATRCAC	STREME-2	2-CACACACACATRCAC	4.87e-86	1.19e-12
66	MA0496.3	MAFK	MA0496.3	7.51e-15	6.56e-12
67	MA0678.1	OLIG2	MA0678.1	1.13e-14	9.86e-12
11	MA1107.2 (KLF9)	STREME-3	3-CACACACACACAD	6.75e-116	1.19e-10
68	MA0058.3	MAX	MA0058.3	1.53e-13	1.33e-10
21	4-CACACAYGCAC	STREME-4	4-CACACAYGCAC	2.38e-98	2.83e-10
10	MA1107.2 (KLF9)	MEME-5	ACACABACAYACA	5.94e-117	5e-10
4	MA1155.1 (ZSCAN4)	MEME-17	TGTGTRTGTGTGTG	1.09e-119	7.8e-10
8	MA1990.1 (Gli1)	STREME-5	5-CACACACCACACACA	3.91e-118	7.98e-10
69	MA1107.2	KLF9	MA1107.2	1.03e-12	9.03e-10
70	MA0622.1	Mlxip	MA0622.1	1.53e-12	1.34e-09
71	MA0817.1	BHLHE23	MA0817.1	1.82e-12	1.59e-09
15	MA0491.2 (JUND)	STREME-6	6-RATGASTCATY	1.04e-110	2.26e-09
1	7-CACACATACACAC	STREME-7	7-CACACATACACAC	2.85e-143	3.25e-09
72	MA0147.3	MYC	MA0147.3	1.07e-11	9.33e-09
73	MA0849.1	FOXO6	MA0849.1	1.43e-11	1.25e-08
74	MA0818.2	BHLHE22	MA0818.2	1.58e-11	1.38e-08
76	MA1124.1	ZNF24	MA1124.1	3.75e-11	3.28e-08
77	MA0825.1	MNT	MA0825.1	4.4e-11	3.85e-08
78	MA1560.1	SOHLH2	MA1560.1	5.35e-11	4.68e-08
75	YGCCTGTARTCCCAG	MEME-15	YGCCTGTARTCCCAG	2.71e-11	9.9e-08
79	MA1493.1	HES6	MA1493.1	1.41e-10	1.23e-07
6	TGTGTGGTGTGTGTG	MEME-12	TGTGTGGTGTGTGTG	5.3e-119	1.6e-07
80	MA0059.1	MAX::MYC	MA0059.1	2.88e-10	2.52e-07
81	MA0608.1	Creb3l2	MA0608.1	4.21e-10	3.68e-07
82	MA0607.2	BHLHA15	MA0607.2	4.67e-10	4.08e-07
83	MA0150.2	Nfe2l2	MA0150.2	9.13e-10	7.98e-07
84	MA0804.1	TBX19	MA0804.1	2.58e-09	2.26e-06
13	8-CAYRCACAC	STREME-8	8-CAYRCACAC	2.99e-114	3.22e-06
85	MA0827.1	OLIG3	MA0827.1	5.24e-09	4.58e-06
86	MA1606.1	Foxf1	MA1606.1	1.85e-08	1.62e-05
87	MA1464.1	ARNT2	MA1464.1	2.12e-08	1.86e-05
89	MA0689.1	TBX20	MA0689.1	3.09e-08	2.7e-05
90	MA0826.1	OLIG1	MA0826.1	4.67e-08	4.08e-05
92	MA0004.1	Arnt	MA0004.1	5.2e-08	4.55e-05
31	MA1974.1 (ZNF211)	STREME-9	9-MCACACACCACAC	5.48e-87	5.64e-05
93	MA0162.4	EGR1	MA0162.4	7.58e-08	6.63e-05
5	GTGTGTATGTGTG	MEME-14	GTGTGTATGTGTG	2.89e-119	7.1e-05
94	MA1106.1	HIF1A	MA1106.1	8.34e-08	7.29e-05
96	MA0649.1	HEY2	MA0649.1	1.44e-07	0.000126
97	MA0871.2	TFEC	MA0871.2	1.52e-07	0.000133
98	MA1487.2	FOXE1	MA1487.2	1.59e-07	0.000139
99	MA0627.2	POU2F3	MA0627.2	1.87e-07	0.000163
100	MA0472.2	EGR2	MA0472.2	2.1e-07	0.000184
101	MA0047.3	FOXA2	MA0047.3	2.4e-07	0.00021
102	MA1990.1	Gli1	MA1990.1	3.8e-07	0.000332
104	MA1559.1	SNAI3	MA1559.1	8.67e-07	0.000758
129	TGTGTGGTGTGTGTG	MEME-16	TGTGTGGTGTGTGTG	2.72	0.00077
105	MA0823.1	HEY1	MA0823.1	1.03e-06	9e-04
14	10-ATGTGTGTG	STREME-10	10-ATGTGTGTG	7.72e-113	0.00165
106	MA1103.2	FOXK2	MA1103.2	2.06e-06	0.0018
107	MA1115.1	POU5F1	MA1115.1	2.31e-06	0.00202
108	MA0464.2	BHLHE40	MA0464.2	2.53e-06	0.00221
109	MA0616.2	HES2	MA0616.2	2.73e-06	0.00239
110	MA0836.2	CEBPD	MA0836.2	3.47e-06	0.00304
111	MA0033.2	FOXL1	MA0033.2	3.88e-06	0.00339
52	MA1108.2 (MXI1)	STREME-11	11-TACACATG	1.09e-35	0.00484
112	MA0698.1	ZBTB18	MA0698.1	6.68e-06	0.00584
113	MA1618.1	Ptf1a	MA1618.1	1.15e-05	0.0101
114	MA0461.2	Atoh1	MA0461.2	1.3e-05	0.0113
115	MA0030.1	FOXF2	MA0030.1	1.41e-05	0.0123
116	MA0847.3	FOXD2	MA0847.3	1.44e-05	0.0126
117	MA0632.2	TCFL5	MA0632.2	1.79e-05	0.0156
118	MA1491.2	GLI3	MA1491.2	1.98e-05	0.0173
119	MA0615.1	Gmeb1	MA0615.1	2.43e-05	0.0213
120	MA0845.1	FOXB1	MA0845.1	2.78e-05	0.0243
121	MA0148.4	FOXA1	MA0148.4	4.09e-05	0.0357
122	MA0009.2	TBXT	MA0009.2	4.17e-05	0.0364
123	MA0646.1	GCM1	MA0646.1	4.65e-05	0.0406
124	MA0733.1	EGR4	MA0733.1	5.68e-05	0.0496
91	12-CGAGTGATCCGCC	STREME-12	12-CGAGTGATCCGCC	4.76e-08	0.0562
54	13-ACACAGG	STREME-13	13-ACACAGG	9.1e-35	0.0565
49	14-ACACAY	STREME-14	14-ACACAY	4.01e-43	0.0572
65	MA1601.2 (ZNF75D)	STREME-15	15-GGCATGCCCACAGT	1.9e-16	4.36
128	MA0052.4 (MEF2A)	STREME-16	16-TATTTTTAGWA	0.00293	6.41
103	MA1964.1 (SMAD2)	STREME-17	17-CCCGTCTGGGAAGT	6.42e-07	17

ESR_close_xstreme %>% 
  dplyr::select(RANK,SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
  arrange(.,EVALUE) %>%
   dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  # dplyr::filter(., EVALUE<0.05) %>% 
  kable(., caption = "Enriched motifs  ESR close") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "800px")

Enriched motifs ESR close
RANK	SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
3	MA1653.1	ZNF148	MA1653.1	6.2e-144	5.35e-141
4	MA0493.2	KLF1	MA0493.2	4.59e-141	3.96e-138
5	MA0685.2	SP4	MA0685.2	7.2e-138	6.2e-135
6	MA1959.1	KLF7	MA1959.1	2.94e-133	2.53e-130
7	MA1522.1	MAZ	MA1522.1	9.09e-133	7.83e-130
8	MA1511.2	KLF10	MA1511.2	2.36e-132	2.03e-129
10	MA0742.2	KLF12	MA0742.2	2.25e-131	1.94e-128
11	MA1630.2	ZNF281	MA1630.2	3e-130	2.59e-127
13	MA0741.1	KLF16	MA0741.1	1.01e-126	8.71e-124
14	MA0740.2	KLF14	MA0740.2	1.74e-126	1.5e-123
15	MA0079.5	SP1	MA0079.5	7.28e-122	6.28e-119
16	MA0599.1	KLF5	MA0599.1	3.49e-120	3.01e-117
18	MA0753.2	ZNF740	MA0753.2	3.09e-118	2.67e-115
19	MA1713.1	ZNF610	MA1713.1	5.98e-113	5.16e-110
20	MA0516.3	SP2	MA0516.3	7.47e-112	6.44e-109
23	MA0146.2	Zfx	MA0146.2	2.93e-109	2.52e-106
24	MA1107.2	KLF9	MA1107.2	3.95e-109	3.4e-106
25	MA1650.1	ZBTB14	MA1650.1	2.82e-108	2.43e-105
26	MA1564.1	SP9	MA1564.1	2.94e-106	2.54e-103
27	MA0746.2	SP3	MA0746.2	2.58e-105	2.23e-102
28	MA0774.1	MEIS2	MA0774.1	2.05e-104	1.76e-101
29	MA1961.1	PATZ1	MA1961.1	3.04e-104	2.62e-101
30	MA1548.1	PLAGL2	MA1548.1	5.47e-104	4.71e-101
31	MA0039.4	KLF4	MA0039.4	8.53e-104	7.35e-101
32	MA1578.1	VEZF1	MA1578.1	5.18e-101	4.46e-98
33	MA1615.1	Plagl1	MA1615.1	1.02e-99	8.76e-97
34	MA0597.2	THAP1	MA0597.2	2.47e-98	2.13e-95
35	MA0162.4	EGR1	MA0162.4	2.74e-97	2.37e-94
37	MA1515.1	KLF2	MA1515.1	5.49e-95	4.73e-92
38	MA1965.1	SP5	MA1965.1	1.03e-91	8.85e-89
39	MA0810.1	TFAP2A	MA0810.1	1.16e-91	9.95e-89
40	MA1643.1	NFIB	MA1643.1	1.37e-91	1.18e-88
41	MA1102.2	CTCFL	MA1102.2	1.71e-91	1.48e-88
42	MA1627.1	Wt1	MA1627.1	8.8e-91	7.59e-88
43	MA1981.1	ZNF530	MA1981.1	6.2e-89	5.34e-86
47	MA1514.1	KLF17	MA1514.1	7.01e-85	6.04e-82
48	MA1712.1	ZNF454	MA1712.1	2.77e-84	2.39e-81
49	MA1986.1	ZNF692	MA1986.1	1.52e-82	1.31e-79
50	MA0747.1	SP8	MA0747.1	3.77e-81	3.25e-78
51	MA1599.1	ZNF682	MA1599.1	3.49e-79	3.01e-76
52	MA1516.1	KLF3	MA1516.1	6.69e-79	5.76e-76
53	MA1719.1	ZNF816	MA1719.1	2.01e-77	1.73e-74
54	MA1512.1	KLF11	MA1512.1	1.99e-76	1.72e-73
55	MA1517.1	KLF6	MA1517.1	5.35e-75	4.61e-72
56	MA0738.1	HIC2	MA0738.1	2.64e-74	2.28e-71
57	MA1721.1	ZNF93	MA1721.1	4.13e-74	3.56e-71
58	MA0528.2	ZNF263	MA0528.2	2.78e-73	2.39e-70
59	MA1596.1	ZNF460	MA1596.1	1.17e-71	1.01e-68
60	MA0131.2	HINFP	MA0131.2	1.66e-71	1.43e-68
61	MA1527.1	NFIC	MA1527.1	7.62e-71	6.57e-68
62	MA1976.1	ZNF320	MA1976.1	1.14e-70	9.79e-68
63	MA1723.1	PRDM9	MA1723.1	2.5e-70	2.15e-67
65	MA1528.1	NFIX	MA1528.1	4.83e-70	4.16e-67
66	MA1631.1	ASCL1	MA1631.1	3.19e-68	2.75e-65
67	MA0811.1	TFAP2B	MA0811.1	6.6e-68	5.69e-65
68	MA0775.1	MEIS3	MA0775.1	1.22e-67	1.05e-64
69	MA0751.1	ZIC4	MA0751.1	1.75e-67	1.51e-64
71	MA1656.1	ZNF449	MA1656.1	1.08e-65	9.34e-63
72	MA1710.1	ZNF257	MA1710.1	1.14e-65	9.79e-63
73	MA0524.2	TFAP2C	MA0524.2	1.67e-65	1.44e-62
74	MA0471.2	E2F6	MA0471.2	3.59e-65	3.09e-62
75	MA0119.1	NFIC::TLX1	MA0119.1	3.47e-64	2.99e-61
76	MA0830.2	TCF4	MA0830.2	3.46e-63	2.98e-60
77	MA0130.1	ZNF354C	MA0130.1	6.66e-61	5.74e-58
78	MA1648.1	TCF12	MA1648.1	7.57e-57	6.53e-54
79	MA0734.3	Gli2	MA0734.3	1.23e-56	1.06e-53
80	MA1728.1	ZNF549	MA1728.1	1.88e-56	1.62e-53
81	MA1635.1	BHLHE22	MA1635.1	1.05e-55	9.03e-53
82	MA0646.1	GCM1	MA0646.1	5.21e-55	4.49e-52
83	MA0814.2	TFAP2C	MA0814.2	8.78e-55	7.57e-52
84	MA0506.2	Nrf1	MA0506.2	1e-54	8.66e-52
85	MA0048.2	NHLH1	MA0048.2	1.96e-54	1.69e-51
86	MA0733.1	EGR4	MA0733.1	3.69e-54	3.18e-51
87	MA0504.1	NR2C2	MA0504.1	7.01e-54	6.05e-51
88	MA0739.1	Hic1	MA0739.1	1.05e-53	9.08e-51
89	MA1628.1	Zic1::Zic2	MA1628.1	2.65e-53	2.28e-50
90	MA0003.4	TFAP2A	MA0003.4	8.58e-53	7.4e-50
91	MA0672.1	NKX2-3	MA0672.1	2.77e-52	2.39e-49
92	MA1997.1	Olig2	MA1997.1	3.98e-52	3.43e-49
93	MA0633.2	Twist2	MA0633.2	7.47e-52	6.44e-49
94	MA1535.1	NR2C1	MA1535.1	8.34e-52	7.19e-49
95	MA0803.1	TBX15	MA0803.1	1.04e-51	9.01e-49
96	MA1987.1	ZNF701	MA1987.1	5.77e-51	4.97e-48
97	MA0872.1	TFAP2A	MA0872.1	9.64e-51	8.31e-48
98	MA0697.2	Zic3	MA0697.2	6.33e-50	5.45e-47
99	MA1982.1	ZNF574	MA1982.1	7.44e-50	6.42e-47
100	MA1122.1	TFDP1	MA1122.1	1.5e-49	1.29e-46
102	MA1629.1	Zic2	MA1629.1	3.47e-48	2.99e-45
103	MA1972.1	ZFP14	MA1972.1	8.18e-48	7.05e-45
105	MA1979.1	ZNF416	MA1979.1	2.87e-47	2.47e-44
106	MA1993.1	Neurod2	MA1993.1	5.19e-47	4.48e-44
107	MA1730.1	ZNF708	MA1730.1	1.51e-46	1.31e-43
108	MA1985.1	ZNF669	MA1985.1	1.76e-46	1.52e-43
109	MA0104.4	MYCN	MA0104.4	1.89e-46	1.63e-43
110	MA0694.1	ZBTB7B	MA0694.1	2.22e-46	1.91e-43
111	MA0812.1	TFAP2B	MA0812.1	2.39e-46	2.06e-43
112	MA1973.1	ZKSCAN3	MA1973.1	4.78e-46	4.12e-43
113	MA0745.2	SNAI2	MA0745.2	7.74e-46	6.67e-43
114	MA1637.1	EBF3	MA1637.1	1.64e-45	1.42e-42
115	MA0145.2	Tfcp2l1	MA0145.2	1.74e-45	1.5e-42
116	MA0155.1	INSM1	MA0155.1	6.8e-45	5.86e-42
117	MA0807.1	TBX5	MA0807.1	8.6e-45	7.42e-42
118	MA0500.2	MYOG	MA0500.2	1.11e-44	9.6e-42
119	MA1604.1	Ebf2	MA1604.1	1.63e-44	1.41e-41
120	MA0258.2	ESR2	MA0258.2	1.64e-44	1.41e-41
121	MA0816.1	Ascl2	MA0816.1	1.66e-44	1.43e-41
122	MA0522.3	TCF3	MA0522.3	1.91e-44	1.65e-41
123	MA0103.3	ZEB1	MA0103.3	4.7e-44	4.05e-41
124	MA0767.1	GCM2	MA0767.1	1.34e-43	1.15e-40
125	MA1990.1	Gli1	MA1990.1	1.72e-43	1.48e-40
126	MA1652.1	ZKSCAN5	MA1652.1	3.07e-42	2.65e-39
127	MA0159.1	RARA::RXRA	MA0159.1	8.94e-42	7.71e-39
128	MA1641.1	MYF5	MA1641.1	1.01e-41	8.7e-39
129	MA0736.1	GLIS2	MA0736.1	3.45e-41	2.97e-38
130	MA0865.2	E2F8	MA0865.2	4.65e-41	4.01e-38
131	MA0154.4	EBF1	MA0154.4	1.27e-40	1.1e-37
132	MA1100.2	ASCL1	MA1100.2	1.36e-40	1.17e-37
133	MA1727.1	ZNF417	MA1727.1	3.7e-39	3.19e-36
134	MA1472.2	Bhlha15	MA1472.2	7.02e-39	6.05e-36
135	MA0671.1	NFIX	MA0671.1	1.35e-38	1.16e-35
136	MA1621.1	Rbpjl	MA1621.1	5.14e-38	4.43e-35
137	MA1567.2	Tbx6	MA1567.2	1.01e-37	8.69e-35
138	MA2003.1	NKX2-4	MA2003.1	2.1e-35	1.81e-32
139	MA1587.1	ZNF135	MA1587.1	2.54e-35	2.19e-32
140	MA0820.1	FIGLA	MA0820.1	2.79e-35	2.4e-32
141	MA0649.1	HEY2	MA0649.1	5.31e-35	4.58e-32
142	MA0805.1	TBX1	MA0805.1	1.19e-34	1.02e-31
143	MA2002.1	Zfp335	MA2002.1	1.2e-34	1.03e-31
144	MA0511.2	RUNX2	MA0511.2	1.26e-34	1.09e-31
145	MA0821.2	HES5	MA0821.2	2.15e-34	1.85e-31
146	MA1726.1	ZNF331	MA1726.1	2.25e-34	1.94e-31
147	MA0499.2	MYOD1	MA0499.2	3.37e-34	2.9e-31
148	MA0065.2	Pparg::Rxra	MA0065.2	9.98e-34	8.61e-31
149	MA0748.2	YY2	MA0748.2	1.46e-33	1.26e-30
150	MA0695.1	ZBTB7C	MA0695.1	1.77e-33	1.52e-30
151	MA1149.1	RARA::RXRG	MA1149.1	1.98e-33	1.71e-30
152	MA0521.2	Tcf12	MA0521.2	2.3e-33	1.99e-30
153	MA1731.1	ZNF768	MA1731.1	2.6e-33	2.24e-30
154	MA0806.1	TBX4	MA0806.1	5.18e-33	4.46e-30
155	MA0665.1	MSC	MA0665.1	6.34e-33	5.46e-30
156	MA0014.3	PAX5	MA0014.3	6.58e-33	5.67e-30
157	MA1581.1	ZBTB6	MA1581.1	1.08e-32	9.3e-30
158	MA0472.2	EGR2	MA0472.2	2.23e-32	1.92e-29
159	MA1620.1	Ptf1A	MA1620.1	4.74e-32	4.08e-29
160	MA1600.1	ZNF684	MA1600.1	6.24e-32	5.38e-29
161	MA1574.1	THRB	MA1574.1	1.07e-31	9.21e-29
162	MA0071.1	RORA	MA0071.1	3.04e-31	2.62e-28
163	MA0750.2	ZBTB7A	MA0750.2	3.83e-31	3.31e-28
164	MA1619.1	Ptf1A	MA1619.1	4.72e-31	4.07e-28
9	MA0039.4 (KLF4)	MEME-3	SWGGSWGGAGK	1.79e-131	6.2e-28
165	MA0498.2	MEIS1	MA0498.2	1.4e-30	1.21e-27
166	MA0161.2	NFIC	MA0161.2	2.08e-30	1.79e-27
168	MA1566.2	TBX3	MA1566.2	4.18e-30	3.6e-27
169	MA0815.1	TFAP2C	MA0815.1	7.71e-30	6.65e-27
170	MA0139.1	CTCF	MA0139.1	8.87e-30	7.65e-27
171	MA0691.1	TFAP4	MA0691.1	1.05e-29	9.09e-27
172	MA1565.1	TBX18	MA1565.1	1.08e-29	9.33e-27
173	MA1964.1	SMAD2	MA1964.1	2.07e-29	1.79e-26
174	MA1583.1	ZFP57	MA1583.1	2.83e-29	2.44e-26
175	MA1474.1	CREB3L4	MA1474.1	1.01e-28	8.75e-26
176	MA0006.1	Ahr::Arnt	MA0006.1	1.19e-27	1.03e-24
177	MA1941.1	ETV2::FIGLA	MA1941.1	1.88e-27	1.62e-24
178	MA1966.1	TFAP4::ETV1	MA1966.1	9.87e-27	8.51e-24
179	MA0783.1	PKNOX2	MA0783.1	1.05e-26	9.05e-24
180	MA0813.1	TFAP2B	MA0813.1	8.36e-26	7.21e-23
181	MA0670.1	NFIA	MA0670.1	8.95e-26	7.71e-23
182	MA0595.1	SREBF1	MA0595.1	1.2e-25	1.04e-22
183	MA1109.1	NEUROD1	MA1109.1	3.23e-25	2.78e-22
184	MA1945.1	ETV5::FIGLA	MA1945.1	3.66e-25	3.15e-22
185	MA0801.1	MGA	MA0801.1	4.2e-25	3.62e-22
186	MA1558.1	SNAI1	MA1558.1	4.27e-25	3.68e-22
187	MA0664.1	MLXIPL	MA0664.1	6.58e-25	5.67e-22
188	MA0797.1	TGIF2	MA0797.1	7.82e-25	6.74e-22
44	MA1723.1 (PRDM9)	MEME-1	RGSWGGGMWGG	2.77e-87	2.4e-21
189	MA0596.1	SREBF2	MA0596.1	2.88e-24	2.48e-21
190	MA0017.2	NR2F1	MA0017.2	4e-24	3.45e-21
191	MA0692.1	TFEB	MA0692.1	4.13e-23	3.56e-20
192	MA0796.1	TGIF1	MA0796.1	1.5e-21	1.3e-18
193	MA0626.1	Npas2	MA0626.1	2.31e-21	1.99e-18
327	MA1125.1 (ZNF384)	MEME-2	AAAAAAAAAAAAAAA	0.0161	3e-18
194	MA1531.1	NR1D1	MA1531.1	3.59e-21	3.09e-18
195	MA0668.2	Neurod2	MA0668.2	5.21e-21	4.49e-18
196	MA1493.1	HES6	MA1493.1	6.07e-21	5.24e-18
197	MA1929.1	CTCF	MA1929.1	8.88e-21	7.66e-18
198	MA1715.1	ZNF707	MA1715.1	1.04e-20	8.97e-18
199	MA1571.1	TGIF2LX	MA1571.1	2.06e-20	1.77e-17
200	MA0698.1	ZBTB18	MA0698.1	2.54e-20	2.19e-17
201	MA0502.2	NFYB	MA0502.2	5.09e-20	4.39e-17
202	MA1114.1	PBX3	MA1114.1	8.97e-20	7.73e-17
203	MA0632.2	TCFL5	MA0632.2	1.05e-19	9.07e-17
204	MA1655.1	ZNF341	MA1655.1	1.06e-19	9.15e-17
205	MA1645.1	NKX2-2	MA1645.1	5.54e-19	4.78e-16
206	MA0677.1	Nr2f6	MA0677.1	6.54e-19	5.63e-16
207	MA1108.2	MXI1	MA1108.2	8.03e-19	6.92e-16
208	MA1572.1	TGIF2LY	MA1572.1	1.12e-18	9.69e-16
209	MA1560.1	SOHLH2	MA1560.1	1.47e-18	1.27e-15
1	MA1653.1 (ZNF148)	STREME-1	1-CCCCWCCCM	6.38e-172	1.51e-15
210	MA0092.1	Hand1::Tcf3	MA0092.1	2.46e-18	2.12e-15
211	MA1996.1	Nr1H2	MA1996.1	2.91e-18	2.51e-15
212	MA0782.2	PKNOX1	MA0782.2	4.59e-18	3.96e-15
213	MA1569.1	TFAP2E	MA1569.1	4.95e-18	4.27e-15
214	MA0018.4	CREB1	MA0018.4	2.31e-17	1.99e-14
215	MA0645.1	ETV6	MA0645.1	2.38e-17	2.05e-14
216	MA0058.3	MAX	MA0058.3	7.59e-17	6.54e-14
217	MA0259.1	ARNT::HIF1A	MA0259.1	1.83e-16	1.58e-13
218	MA1570.1	TFAP4	MA1570.1	5.71e-16	4.92e-13
219	MA0060.3	NFYA	MA0060.3	5.81e-16	5e-13
220	MA0690.2	TBX21	MA0690.2	6.68e-16	5.76e-13
222	MA0608.1	Creb3l2	MA0608.1	8.02e-16	6.92e-13
223	MA1992.1	Ikzf3	MA1992.1	2.39e-15	2.06e-12
224	MA0667.1	MYF6	MA0667.1	2.52e-15	2.17e-12
225	MA0831.3	TFE3	MA0831.3	3.33e-15	2.87e-12
226	MA1642.1	NEUROG2	MA1642.1	3.46e-15	2.98e-12
2	MA1527.1 (NFIC)	STREME-2	2-GSTGNCASC	1.29e-157	4.3e-12
227	MA1601.2	ZNF75D	MA1601.2	7.58e-15	6.54e-12
228	MA0696.1	ZIC1	MA0696.1	2e-14	1.72e-11
229	MA0823.1	HEY1	MA0823.1	2.28e-14	1.96e-11
329	MA1547.2 (PITX2)	MEME-4	AAAGTGCTGGGATTA	0.289	2.1e-11
230	MA1153.1	Smad4	MA1153.1	2.55e-14	2.19e-11
231	MA0766.2	GATA5	MA0766.2	5.37e-14	4.63e-11
232	MA1716.1	ZNF76	MA1716.1	5.64e-14	4.86e-11
233	MA0147.3	MYC	MA0147.3	7.11e-14	6.13e-11
234	MA0673.1	NKX2-8	MA0673.1	7.25e-14	6.25e-11
235	MA0163.1	PLAG1	MA0163.1	1.19e-13	1.02e-10
236	MA0124.2	Nkx3-1	MA0124.2	1.75e-13	1.51e-10
237	MA0464.2	BHLHE40	MA0464.2	3.78e-13	3.26e-10
238	MA0688.1	TBX2	MA0688.1	4.23e-13	3.65e-10
12	MA1513.1 (KLF15)	STREME-3	3-CCAGCCC	6.85e-130	3.93e-10
239	MA0669.1	NEUROG2	MA0669.1	4.82e-13	4.15e-10
240	MA1559.1	SNAI3	MA1559.1	5.04e-13	4.34e-10
241	MA0829.2	SREBF1	MA0829.2	8.25e-13	7.11e-10
242	MA1533.1	NR1I2	MA1533.1	1.12e-12	9.66e-10
243	MA1485.1	FERD3L	MA1485.1	1.76e-12	1.51e-09
244	MA0056.2	MZF1	MA0056.2	2.27e-12	1.95e-09
245	MA0825.1	MNT	MA0825.1	2.91e-12	2.5e-09
246	MA1468.1	ATOH7	MA1468.1	6.91e-12	5.95e-09
247	MA1618.1	Ptf1a	MA1618.1	1.17e-11	1.01e-08
248	MA0802.1	TBR1	MA0802.1	1.47e-11	1.27e-08
249	MA1537.1	NR2F1	MA1537.1	1.58e-11	1.36e-08
250	MA1554.1	RFX7	MA1554.1	1.72e-11	1.48e-08
251	MA0093.3	USF1	MA0093.3	2.53e-11	2.18e-08
252	MA0764.3	ETV4	MA0764.3	3.16e-11	2.73e-08
253	MA0073.1	RREB1	MA0073.1	3.89e-11	3.35e-08
254	MA1542.1	OSR1	MA1542.1	4.23e-11	3.65e-08
255	MA0505.2	Nr5A2	MA0505.2	6.86e-11	5.92e-08
256	MA0488.1	JUN	MA0488.1	1.43e-10	1.23e-07
257	MA0689.1	TBX20	MA0689.1	3.54e-10	3.06e-07
258	MA1475.1	CREB3L4	MA1475.1	3.75e-10	3.24e-07
259	MA1523.1	MSANTD3	MA1523.1	3.88e-10	3.35e-07
260	MA1638.1	HAND2	MA1638.1	4.06e-10	3.5e-07
261	MA1467.2	Atoh1	MA1467.2	6.08e-10	5.24e-07
262	MA1123.2	TWIST1	MA1123.2	6.42e-10	5.54e-07
17	MA1979.1 (ZNF416)	STREME-4	4-CTGGGCC	4.99e-119	6.62e-07
45	MA1629.1 (Zic2)	STREME-5	5-CACAGCAG	8.19e-87	7.02e-07
263	MA1540.2	NR5A1	MA1540.2	8.29e-10	7.15e-07
264	MA1724.1	Rfx6	MA1724.1	1.14e-09	9.84e-07
265	MA1644.1	NFYC	MA1644.1	1.4e-09	1.21e-06
266	MA0607.2	BHLHA15	MA0607.2	1.72e-09	1.48e-06
267	MA1708.1	ETV7	MA1708.1	1.79e-09	1.55e-06
268	MA0492.1	JUND	MA0492.1	1.85e-09	1.6e-06
269	MA0111.1	Spz1	MA0111.1	2.25e-09	1.94e-06
270	MA0091.1	TAL1::TCF3	MA0091.1	3.09e-09	2.66e-06
271	MA0737.1	GLIS3	MA0737.1	3.29e-09	2.84e-06
272	MA0832.1	Tcf21	MA0832.1	3.8e-09	3.28e-06
273	MA0002.2	Runx1	MA0002.2	4.22e-09	3.64e-06
274	MA0141.3	ESRRB	MA0141.3	4.5e-09	3.88e-06
275	MA1593.1	ZNF317	MA1593.1	5.51e-09	4.75e-06
22	MA0528.2 (ZNF263)	STREME-6	6-CCTCCC	2.51e-109	5.06e-06
276	MA0036.3	GATA2	MA0036.3	6.15e-09	5.3e-06
277	MA1725.1	ZNF189	MA1725.1	7.96e-09	6.86e-06
278	MA0871.2	TFEC	MA0871.2	8.52e-09	7.34e-06
279	MA1099.2	HES1	MA1099.2	1.62e-08	1.4e-05
280	MA1556.1	RXRG	MA1556.1	1.97e-08	1.7e-05
281	MA0643.1	Esrrg	MA0643.1	1.98e-08	1.71e-05
328	MA1596.1 (ZNF460)	MEME-5	GGGAGGCYGAGGCAG	0.106	1.8e-05
282	MA0609.2	CREM	MA0609.2	2.1e-08	1.81e-05
283	MA1116.1	RBPJ	MA1116.1	2.21e-08	1.91e-05
284	MA1984.1	ZNF667	MA1984.1	2.48e-08	2.14e-05
285	MA1573.2	Thap11	MA1573.2	2.77e-08	2.39e-05
286	MA1557.1	SMAD5	MA1557.1	3.22e-08	2.77e-05
287	MA0623.2	NEUROG1	MA0623.2	5.37e-08	4.63e-05
288	MA1110.2	Nr1H4	MA1110.2	6.05e-08	5.21e-05
289	MA1711.1	ZNF343	MA1711.1	7.9e-08	6.81e-05
290	MA1111.1	NR2F2	MA1111.1	8.49e-08	7.32e-05
291	MA1513.1	KLF15	MA1513.1	9.13e-08	7.87e-05
292	MA1117.1	RELB	MA1117.1	9.8e-08	8.45e-05
293	MA0473.3	ELF1	MA0473.3	1.15e-07	9.94e-05
294	MA1529.1	NHLH2	MA1529.1	2.3e-07	0.000198
295	MA0062.3	GABPA	MA0062.3	2.84e-07	0.000245
296	MA1555.1	RXRB	MA1555.1	2.94e-07	0.000254
297	MA1106.1	HIF1A	MA1106.1	3.5e-07	0.000302
21	7-GCCWGGC	STREME-7	7-GCCWGGC	2.19e-109	0.000332
298	MA0818.2	BHLHE22	MA0818.2	4.55e-07	0.000392
299	MA0640.2	ELF3	MA0640.2	4.62e-07	0.000398
300	MA1967.1	TFAP4::FLI1	MA1967.1	4.63e-07	0.000399
301	MA1495.1	HOXA1	MA1495.1	5.4e-07	0.000465
302	MA1999.1	Prdm5	MA1999.1	5.41e-07	0.000466
303	MA0482.2	GATA4	MA0482.2	6.25e-07	0.000539
304	MA0904.2	HOXB5	MA0904.2	6.79e-07	0.000586
305	MA0732.1	EGR3	MA0732.1	1.06e-06	0.000912
104	MA1983.1 (ZNF582)	STREME-8	8-GCAGCC	9.53e-48	0.000988
306	MA1584.1	ZIC5	MA1584.1	1.35e-06	0.00116
307	MA1969.1	THRA	MA1969.1	1.64e-06	0.00141
308	MA0138.2	REST	MA0138.2	1.83e-06	0.00158
309	MA1717.1	ZNF784	MA1717.1	2.86e-06	0.00246
310	MA1998.1	Prdm14	MA1998.1	3.19e-06	0.00275
167	MA0782.2 (PKNOX1)	STREME-9	9-AGTGMCAGT	2.25e-30	0.00305
36	MA1722.1 (ZSCAN31)	STREME-10	10-CAGGGC	5.47e-95	0.00309
311	MA0592.3	ESRRA	MA0592.3	3.94e-06	0.0034
312	MA0474.3	Erg	MA0474.3	4.12e-06	0.00355
313	MA0063.2	NKX2-5	MA0063.2	6.6e-06	0.00569
326	MA1988.1 (Atf3)	MEME-6	CAGGCRTGAGCCACY	0.000708	0.0057
64	MA0003.4 (TFAP2A)	STREME-11	11-CCCTCAG	3.8e-70	0.00615
314	MA0860.1	Rarg	MA0860.1	9.4e-06	0.00811
315	MA0707.2	MNX1	MA0707.2	9.6e-06	0.00828
316	MA0616.2	HES2	MA0616.2	1.23e-05	0.0106
317	MA1532.2	NR1D2	MA1532.2	1.38e-05	0.0119
318	MA1632.1	ATF2	MA1632.1	1.4e-05	0.0121
319	MA0778.1	NFKB2	MA0778.1	1.46e-05	0.0126
320	MA0800.1	EOMES	MA0800.1	1.7e-05	0.0146
321	MA1654.1	ZNF16	MA1654.1	1.83e-05	0.0158
322	MA1944.1	ETV5::DRGX	MA1944.1	2.15e-05	0.0185
46	MA1102.2 (CTCFL)	STREME-12	12-AGGGGG	2.31e-85	0.029
323	MA0842.2	NRL	MA0842.2	4.36e-05	0.0376
324	MA0730.1	RARA	MA0730.1	4.39e-05	0.0379
325	MA0603.1	Arntl	MA0603.1	4.81e-05	0.0415
70	MA1964.1 (SMAD2)	STREME-13	13-CAGACAG	5.44e-67	1.32
221	MA1994.1 (Nkx2-1)	STREME-14	14-MCACTTGA	7.24e-16	2.55
101	15-CAGAGG	STREME-15	15-CAGAGG	5.52e-49	4.3

ESR_close_200xstreme %>% 
  dplyr::select(RANK,SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
  arrange(.,EVALUE) %>%
   dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  # dplyr::filter(., EVALUE<0.05) %>% 
  kable(., caption = "Enriched motifs  ESR close 200bp") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "800px")

Enriched motifs ESR close 200bp
RANK	SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
48	MA1723.1 (PRDM9)	MEME-1	YCCCYMHYCCCWSCY	6.89e-56	6.6e-96
10	MA1653.1	ZNF148	MA1653.1	5.37e-97	4.67e-94
11	MA0774.1	MEIS2	MA0774.1	1.53e-96	1.33e-93
13	MA1961.1	PATZ1	MA1961.1	1.85e-89	1.6e-86
14	MA1959.1	KLF7	MA1959.1	4.84e-89	4.2e-86
15	MA1630.2	ZNF281	MA1630.2	1.63e-87	1.42e-84
16	MA0742.2	KLF12	MA0742.2	1.32e-86	1.14e-83
18	MA0493.2	KLF1	MA0493.2	4.38e-86	3.8e-83
20	MA1511.2	KLF10	MA1511.2	9.52e-85	8.26e-82
21	MA0685.2	SP4	MA0685.2	1.29e-83	1.12e-80
23	MA0599.1	KLF5	MA0599.1	7.72e-79	6.7e-76
24	MA1643.1	NFIB	MA1643.1	1.72e-78	1.49e-75
25	MA1522.1	MAZ	MA1522.1	3.2e-78	2.78e-75
26	MA0740.2	KLF14	MA0740.2	3.33e-78	2.89e-75
27	MA0753.2	ZNF740	MA0753.2	2.09e-77	1.81e-74
28	MA0079.5	SP1	MA0079.5	5.56e-77	4.83e-74
29	MA1965.1	SP5	MA1965.1	6.63e-75	5.76e-72
30	MA0741.1	KLF16	MA0741.1	4.79e-71	4.16e-68
31	MA0516.3	SP2	MA0516.3	1.55e-69	1.35e-66
32	MA0746.2	SP3	MA0746.2	6.08e-69	5.27e-66
33	MA0119.1	NFIC::TLX1	MA0119.1	3.72e-68	3.23e-65
34	MA1981.1	ZNF530	MA1981.1	4.54e-67	3.94e-64
35	MA1650.1	ZBTB14	MA1650.1	4.63e-67	4.02e-64
37	MA1527.1	NFIC	MA1527.1	3.5e-65	3.04e-62
38	MA0162.4	EGR1	MA0162.4	1.69e-64	1.47e-61
39	MA1528.1	NFIX	MA1528.1	3.94e-64	3.43e-61
40	MA1713.1	ZNF610	MA1713.1	1.51e-63	1.31e-60
41	MA1564.1	SP9	MA1564.1	5.21e-63	4.52e-60
42	MA1512.1	KLF11	MA1512.1	3.15e-61	2.73e-58
45	MA1548.1	PLAGL2	MA1548.1	1.17e-58	1.01e-55
47	MA1578.1	VEZF1	MA1578.1	2.76e-58	2.39e-55
50	MA1627.1	Wt1	MA1627.1	1.11e-54	9.64e-52
51	MA0597.2	THAP1	MA0597.2	8.31e-54	7.21e-51
52	MA1515.1	KLF2	MA1515.1	5.35e-52	4.64e-49
53	MA1102.2	CTCFL	MA1102.2	2.28e-51	1.98e-48
54	MA1615.1	Plagl1	MA1615.1	2.09e-49	1.81e-46
55	MA1514.1	KLF17	MA1514.1	2.12e-46	1.84e-43
56	MA0039.4	KLF4	MA0039.4	4.92e-46	4.27e-43
57	MA0155.1	INSM1	MA0155.1	1.28e-45	1.11e-42
58	MA0775.1	MEIS3	MA0775.1	1.89e-45	1.64e-42
59	MA1107.2	KLF9	MA1107.2	2.8e-45	2.43e-42
96	MA1723.1 (PRDM9)	MEME-2	GGSAGRRGSARGGRS	5.41e-27	3.5e-42
60	MA1976.1	ZNF320	MA1976.1	5.63e-45	4.89e-42
61	MA1599.1	ZNF682	MA1599.1	9.56e-44	8.29e-41
63	MA1986.1	ZNF692	MA1986.1	3.32e-43	2.88e-40
64	MA0810.1	TFAP2A	MA0810.1	3.79e-43	3.29e-40
65	MA0672.1	NKX2-3	MA0672.1	4.82e-41	4.18e-38
66	MA1631.1	ASCL1	MA1631.1	7.2e-40	6.25e-37
67	MA1596.1	ZNF460	MA1596.1	9.04e-40	7.84e-37
68	MA1712.1	ZNF454	MA1712.1	2.06e-39	1.79e-36
69	MA0146.2	Zfx	MA0146.2	2.86e-39	2.48e-36
70	MA1516.1	KLF3	MA1516.1	4.56e-36	3.96e-33
71	MA0739.1	Hic1	MA0739.1	6.33e-36	5.49e-33
72	MA0633.2	Twist2	MA0633.2	1.4e-35	1.21e-32
73	MA0747.1	SP8	MA0747.1	1.84e-35	1.6e-32
74	MA2003.1	NKX2-4	MA2003.1	9.66e-35	8.38e-32
75	MA1997.1	Olig2	MA1997.1	1.99e-34	1.73e-31
76	MA0131.2	HINFP	MA0131.2	9.49e-34	8.24e-31
77	MA1719.1	ZNF816	MA1719.1	4.66e-33	4.04e-30
78	MA0504.1	NR2C2	MA0504.1	2.14e-32	1.86e-29
79	MA0797.1	TGIF2	MA0797.1	3.25e-32	2.82e-29
80	MA0830.2	TCF4	MA0830.2	5.64e-32	4.9e-29
81	MA1993.1	Neurod2	MA1993.1	1.08e-31	9.35e-29
82	MA1723.1	PRDM9	MA1723.1	1.3e-31	1.13e-28
83	MA1721.1	ZNF93	MA1721.1	2.53e-31	2.19e-28
84	MA0522.3	TCF3	MA0522.3	2.9e-31	2.51e-28
85	MA0528.2	ZNF263	MA0528.2	3.11e-31	2.7e-28
86	MA0471.2	E2F6	MA0471.2	7.3e-31	6.34e-28
87	MA0498.2	MEIS1	MA0498.2	1.66e-30	1.44e-27
88	MA0524.2	TFAP2C	MA0524.2	2.38e-30	2.07e-27
89	MA1710.1	ZNF257	MA1710.1	3.01e-30	2.61e-27
90	MA0872.1	TFAP2A	MA0872.1	1.01e-29	8.79e-27
91	MA0521.2	Tcf12	MA0521.2	1.47e-29	1.27e-26
92	MA0812.1	TFAP2B	MA0812.1	1.68e-29	1.45e-26
93	MA0738.1	HIC2	MA0738.1	4.56e-29	3.96e-26
94	MA0803.1	TBX15	MA0803.1	2.34e-28	2.03e-25
95	MA0783.1	PKNOX2	MA0783.1	4.67e-28	4.06e-25
97	MA1517.1	KLF6	MA1517.1	7.85e-27	6.81e-24
98	MA0003.4	TFAP2A	MA0003.4	1.05e-26	9.13e-24
99	MA1648.1	TCF12	MA1648.1	2.4e-26	2.08e-23
100	MA0751.1	ZIC4	MA0751.1	2.41e-26	2.1e-23
101	MA0130.1	ZNF354C	MA0130.1	9.45e-26	8.2e-23
102	MA0814.2	TFAP2C	MA0814.2	1.06e-25	9.2e-23
103	MA1987.1	ZNF701	MA1987.1	3.52e-25	3.06e-22
104	MA1728.1	ZNF549	MA1728.1	7.69e-25	6.67e-22
105	MA0811.1	TFAP2B	MA0811.1	1.09e-24	9.5e-22
106	MA1635.1	BHLHE22	MA1635.1	1.32e-24	1.14e-21
107	MA1600.1	ZNF684	MA1600.1	4.37e-24	3.79e-21
108	MA0506.2	Nrf1	MA0506.2	5.32e-24	4.62e-21
109	MA0691.1	TFAP4	MA0691.1	1.34e-23	1.16e-20
110	MA1619.1	Ptf1A	MA1619.1	1.35e-23	1.17e-20
3	MA0774.1 (MEIS2)	STREME-1	1-RGCTGTCA	1.96e-124	2.27e-20
111	MA0673.1	NKX2-8	MA0673.1	3.16e-23	2.74e-20
112	MA0499.2	MYOD1	MA0499.2	3.89e-23	3.37e-20
113	MA0734.3	Gli2	MA0734.3	4.77e-23	4.14e-20
114	MA0733.1	EGR4	MA0733.1	1.2e-22	1.04e-19
115	MA0670.1	NFIA	MA0670.1	2.19e-22	1.9e-19
116	MA1979.1	ZNF416	MA1979.1	3.22e-22	2.8e-19
117	MA0796.1	TGIF1	MA0796.1	4.8e-22	4.17e-19
118	MA1656.1	ZNF449	MA1656.1	5.33e-22	4.63e-19
119	MA1982.1	ZNF574	MA1982.1	2.75e-21	2.39e-18
120	MA1641.1	MYF5	MA1641.1	4.04e-21	3.51e-18
121	MA0736.1	GLIS2	MA0736.1	6.15e-21	5.34e-18
122	MA1587.1	ZNF135	MA1587.1	1.3e-20	1.13e-17
265	MA1125.1 (ZNF384)	MEME-3	TTTTTTTTTTTTTTT	0.964	1.7e-17
123	MA0665.1	MSC	MA0665.1	3.59e-20	3.12e-17
124	MA1629.1	Zic2	MA1629.1	1.11e-19	9.63e-17
125	MA0816.1	Ascl2	MA0816.1	1.32e-19	1.14e-16
126	MA0807.1	TBX5	MA0807.1	1.32e-19	1.15e-16
127	MA1628.1	Zic1::Zic2	MA1628.1	1.74e-19	1.51e-16
128	MA0258.2	ESR2	MA0258.2	1.77e-19	1.54e-16
19	CAGCYCWG	MEME-4	CAGCYCWG	4.56e-86	4.6e-16
129	MA0815.1	TFAP2C	MA0815.1	8.29e-19	7.2e-16
130	MA0500.2	MYOG	MA0500.2	8.84e-19	7.68e-16
131	MA0671.1	NFIX	MA0671.1	9.85e-19	8.55e-16
132	MA0048.2	NHLH1	MA0048.2	1.02e-18	8.87e-16
133	MA0694.1	ZBTB7B	MA0694.1	1.03e-18	8.92e-16
134	MA1472.2	Bhlha15	MA1472.2	1.63e-18	1.41e-15
135	MA1571.1	TGIF2LX	MA1571.1	1.64e-18	1.42e-15
137	MA0145.2	Tfcp2l1	MA0145.2	4.11e-18	3.57e-15
138	MA1972.1	ZFP14	MA1972.1	5.69e-18	4.94e-15
139	MA1637.1	EBF3	MA1637.1	3.72e-17	3.23e-14
140	MA2002.1	Zfp335	MA2002.1	3.97e-17	3.44e-14
141	MA1100.2	ASCL1	MA1100.2	5.18e-17	4.5e-14
142	MA1122.1	TFDP1	MA1122.1	9.01e-17	7.82e-14
143	MA0104.4	MYCN	MA0104.4	3.47e-16	3.01e-13
144	MA0071.1	RORA	MA0071.1	3.57e-16	3.1e-13
145	MA1535.1	NR2C1	MA1535.1	3.82e-16	3.32e-13
146	MA0745.2	SNAI2	MA0745.2	8.78e-16	7.62e-13
147	MA0161.2	NFIC	MA0161.2	9.13e-16	7.93e-13
2	MA0597.2 (THAP1)	STREME-2	2-CCCTGCCA	1.3e-125	2.38e-12
148	MA1973.1	ZKSCAN3	MA1973.1	4.47e-15	3.88e-12
22	MA1548.1 (PLAGL2)	STREME-3	3-WGGGCCCW	4.52e-83	4.85e-12
149	MA1730.1	ZNF708	MA1730.1	6.01e-15	5.21e-12
150	MA0750.2	ZBTB7A	MA0750.2	6.86e-15	5.95e-12
151	MA1990.1	Gli1	MA1990.1	1.26e-14	1.09e-11
152	MA0805.1	TBX1	MA0805.1	1.67e-14	1.45e-11
153	MA1114.1	PBX3	MA1114.1	1.96e-14	1.7e-11
155	MA0766.2	GATA5	MA0766.2	4.6e-14	3.99e-11
5	MA1981.1 (ZNF530)	STREME-4	4-WGGGCCTG	3.44e-118	5.44e-11
7	MA1630.2 (ZNF281)	STREME-5	5-CCCCWCCC	1.93e-110	8.3e-11
156	MA0092.1	Hand1::Tcf3	MA0092.1	1.19e-13	1.03e-10
157	MA1985.1	ZNF669	MA1985.1	2.47e-13	2.15e-10
158	MA1567.2	Tbx6	MA1567.2	2.8e-13	2.43e-10
159	MA0649.1	HEY2	MA0649.1	3.16e-13	2.75e-10
160	MA0017.2	NR2F1	MA0017.2	4.25e-13	3.69e-10
161	MA0084.1	SRY	MA0084.1	4.54e-13	3.95e-10
162	MA0073.1	RREB1	MA0073.1	5.36e-13	4.65e-10
163	MA0626.1	Npas2	MA0626.1	6.98e-13	6.06e-10
164	MA0676.1	Nr2e1	MA0676.1	7.96e-13	6.91e-10
165	MA0472.2	EGR2	MA0472.2	8.64e-13	7.5e-10
1	MA1979.1 (ZNF416)	STREME-6	6-SAGCCCWG	2.43e-129	8.57e-10
166	MA0782.2	PKNOX1	MA0782.2	1.04e-12	9e-10
167	MA0154.4	EBF1	MA0154.4	1.51e-12	1.31e-09
168	MA0767.1	GCM2	MA0767.1	2.2e-12	1.91e-09
169	MA1604.1	Ebf2	MA1604.1	2.46e-12	2.13e-09
170	MA0163.1	PLAG1	MA0163.1	3.03e-12	2.63e-09
171	MA1109.1	NEUROD1	MA1109.1	4.52e-12	3.93e-09
172	MA1572.1	TGIF2LY	MA1572.1	6.09e-12	5.29e-09
173	MA1531.1	NR1D1	MA1531.1	1.1e-11	9.55e-09
174	MA1110.2	Nr1H4	MA1110.2	1.12e-11	9.68e-09
175	MA0697.2	Zic3	MA0697.2	1.14e-11	9.9e-09
176	MA0147.3	MYC	MA0147.3	1.55e-11	1.34e-08
177	MA0748.2	YY2	MA0748.2	1.62e-11	1.4e-08
178	MA0596.1	SREBF2	MA0596.1	2.8e-11	2.43e-08
179	MA1726.1	ZNF331	MA1726.1	6.21e-11	5.39e-08
180	MA0664.1	MLXIPL	MA0664.1	6.96e-11	6.04e-08
181	MA1153.1	Smad4	MA1153.1	9.41e-11	8.17e-08
182	MA0720.1	Shox2	MA0720.1	1.67e-10	1.45e-07
9	MA1565.1 (TBX18)	STREME-7	7-CACCTCY	4.08e-99	1.56e-07
183	MA0139.1	CTCF	MA0139.1	1.89e-10	1.64e-07
264	TGTGTGTGTGTGTGT	MEME-5	TGTGTGTGTGTGTGT	0.414	1.7e-07
184	MA0159.1	RARA::RXRA	MA0159.1	2.31e-10	2.01e-07
8	8-CWGSCWG	STREME-8	8-CWGSCWG	2.89e-99	2.08e-07
185	MA0821.2	HES5	MA0821.2	3.28e-10	2.84e-07
186	MA1570.1	TFAP4	MA1570.1	4.24e-10	3.68e-07
187	MA1731.1	ZNF768	MA1731.1	4.42e-10	3.84e-07
188	MA1108.2	MXI1	MA1108.2	5.27e-10	4.58e-07
189	MA1583.1	ZFP57	MA1583.1	6.68e-10	5.8e-07
190	MA0737.1	GLIS3	MA0737.1	1.21e-09	1.05e-06
191	MA1964.1	SMAD2	MA1964.1	1.3e-09	1.12e-06
192	MA0831.3	TFE3	MA0831.3	1.36e-09	1.18e-06
46	MA1643.1 (NFIB)	STREME-9	9-CTTGGCAC	1.56e-58	1.19e-06
62	MA1631.1 (ASCL1)	MEME-7	RGCWGCWGGGVSWGS	3.01e-43	2.1e-06
193	MA0006.1	Ahr::Arnt	MA0006.1	2.85e-09	2.47e-06
194	MA0820.1	FIGLA	MA0820.1	3.51e-09	3.05e-06
195	MA0723.2	VAX2	MA0723.2	3.52e-09	3.06e-06
196	MA0035.4	GATA1	MA0035.4	5.02e-09	4.35e-06
197	MA0674.1	NKX6-1	MA0674.1	5.41e-09	4.69e-06
199	MA0668.2	Neurod2	MA0668.2	6.49e-09	5.64e-06
200	MA0014.3	PAX5	MA0014.3	8.11e-09	7.04e-06
201	MA1727.1	ZNF417	MA1727.1	8.13e-09	7.05e-06
202	MA0806.1	TBX4	MA0806.1	8.68e-09	7.53e-06
203	MA0695.1	ZBTB7C	MA0695.1	8.81e-09	7.65e-06
204	MA0704.1	Lhx4	MA0704.1	1.18e-08	1.02e-05
205	MA0027.2	EN1	MA0027.2	1.39e-08	1.2e-05
206	MA1569.1	TFAP2E	MA1569.1	1.47e-08	1.28e-05
17	MA1630.2 (ZNF281)	MEME-6	GGGGGMDGGGC	1.8e-86	1.3e-05
207	MA1966.1	TFAP4::ETV1	MA1966.1	2.24e-08	1.94e-05
208	MA1642.1	NEUROG2	MA1642.1	2.32e-08	2.01e-05
12	MA0146.2 (Zfx)	STREME-10	10-CAGGCCW	1.7e-96	2.4e-05
209	MA0832.1	Tcf21	MA0832.1	4.18e-08	3.63e-05
210	MA0722.1	VAX1	MA0722.1	5.16e-08	4.48e-05
211	MA0730.1	RARA	MA0730.1	6.82e-08	5.92e-05
212	MA1103.2	FOXK2	MA1103.2	6.96e-08	6.05e-05
213	MA0865.2	E2F8	MA0865.2	7.82e-08	6.79e-05
214	MA0769.2	TCF7	MA0769.2	7.86e-08	6.82e-05
215	MA1574.1	THRB	MA1574.1	8.96e-08	7.77e-05
216	MA1996.1	Nr1H2	MA1996.1	1.15e-07	9.98e-05
217	MA0718.1	RAX	MA0718.1	1.2e-07	0.000104
218	MA0698.1	ZBTB18	MA0698.1	1.25e-07	0.000108
219	MA0511.2	RUNX2	MA0511.2	1.59e-07	0.000138
43	MA1994.1 (Nkx2-1)	STREME-11	11-CCACTTGAS	1.97e-60	0.00015
220	MA1558.1	SNAI1	MA1558.1	1.98e-07	0.000172
221	MA1941.1	ETV2::FIGLA	MA1941.1	2.21e-07	0.000192
222	MA0716.1	PRRX1	MA0716.1	2.77e-07	0.00024
223	MA1606.1	Foxf1	MA1606.1	2.84e-07	0.000246
224	MA0882.1	DLX6	MA0882.1	2.95e-07	0.000256
225	MA0903.1	HOXB3	MA0903.1	3.16e-07	0.000274
226	MA0885.2	Dlx2	MA0885.2	3.35e-07	0.000291
227	MA1104.2	GATA6	MA1104.2	3.6e-07	0.000312
228	MA0648.1	GSC	MA0648.1	5.25e-07	0.000456
229	MA0801.1	MGA	MA0801.1	5.84e-07	0.000507
230	MA1715.1	ZNF707	MA1715.1	7.08e-07	0.000615
231	MA0692.1	TFEB	MA0692.1	1.12e-06	0.000973
232	MA1498.2	HOXA7	MA1498.2	1.27e-06	0.0011
233	MA0595.1	SREBF1	MA0595.1	1.37e-06	0.00119
234	MA0858.1	Rarb	MA0858.1	1.46e-06	0.00127
235	MA1565.1	TBX18	MA1565.1	1.66e-06	0.00144
236	MA1652.1	ZKSCAN5	MA1652.1	2.18e-06	0.0019
237	MA1566.2	TBX3	MA1566.2	2.31e-06	0.002
238	MA0643.1	Esrrg	MA0643.1	2.7e-06	0.00234
239	MA1480.1	DPRX	MA1480.1	2.95e-06	0.00256
240	MA0808.1	TEAD3	MA0808.1	3.43e-06	0.00298
241	MA1152.1	SOX15	MA1152.1	3.83e-06	0.00332
242	MA0696.1	ZIC1	MA0696.1	4.14e-06	0.00359
243	MA0667.1	MYF6	MA0667.1	4.38e-06	0.0038
244	MA1969.1	THRA	MA1969.1	4.53e-06	0.00393
245	MA0630.1	SHOX	MA0630.1	5.81e-06	0.00505
154	12-GCTCTCTTCA	STREME-12	12-GCTCTCTTCA	2.01e-14	0.00512
246	MA0065.2	Pparg::Rxra	MA0065.2	6.01e-06	0.00521
247	MA0879.2	DLX1	MA0879.2	6.98e-06	0.00606
248	MA0899.1	HOXA10	MA0899.1	7.27e-06	0.00631
249	MA0068.2	PAX4	MA0068.2	8.03e-06	0.00697
250	MA1593.1	ZNF317	MA1593.1	1.01e-05	0.00881
4	MA0734.3 (Gli2)	STREME-13	13-CWCCCWG	3.17e-118	0.00907
251	MA1581.1	ZBTB6	MA1581.1	1.08e-05	0.00935
252	MA0116.1	Znf423	MA0116.1	1.74e-05	0.0151
253	MA0721.1	UNCX	MA0721.1	1.84e-05	0.0159
254	MA1620.1	Ptf1A	MA1620.1	2.93e-05	0.0254
198	14-GCAGACTTA	STREME-14	14-GCAGACTTA	6e-09	0.0256
49	15-CCTCTCCA	STREME-15	15-CCTCTCCA	2.89e-55	0.0259
255	MA1476.2	Dlx5	MA1476.2	3.01e-05	0.0261
256	MA0056.2	MZF1	MA0056.2	3.12e-05	0.0271
257	MA0004.1	Arnt	MA0004.1	3.25e-05	0.0282
258	MA0033.2	FOXL1	MA0033.2	3.26e-05	0.0283
259	MA0093.3	USF1	MA0093.3	3.35e-05	0.0291
260	MA0675.1	NKX6-2	MA0675.1	3.6e-05	0.0312
261	MA0149.1	EWSR1-FLI1	MA0149.1	4.06e-05	0.0353
6	MA0783.1 (PKNOX2)	STREME-16	16-STGNCAS	4.18e-113	0.0453
262	MA0650.3	Hoxa13	MA0650.3	5.44e-05	0.0472
36	MA1644.1 (NFYC)	STREME-17	17-CCCATCA	2.43e-66	0.0539
44	MA0697.2 (Zic3)	STREME-18	18-SAGSAGG	2.63e-60	0.794
136	19-GCTTATAGATAAAAC	STREME-19	19-GCTTATAGATAAAAC	2.34e-18	2.19
263	MA0069.1 (PAX6)	STREME-20	20-TACTCAAGCCTCA	0.000149	17.2

ESR_OC_xstreme %>% 
  dplyr::select(SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
  arrange(.,EVALUE) %>%
   dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  # dplyr::filter(., EVALUE<0.05) %>% 
  kable(., caption = "Enriched motifs  in ESR OC") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "800px")

Enriched motifs in ESR OC
SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
MA0659.3	Mafg	MA0659.3	1.2e-305	1.04e-305
MA1130.1	FOSL2::JUN	MA1130.1	1.19e-305	1.05e-305
MA1134.1 (FOS::JUNB)	STREME-1	1-DATGASTCATH	1.09e-305	1.09e-305
MA0680.2	Pax7	MA0680.2	1.33e-305	1.16e-305
MA1142.1	FOSL1::JUND	MA1142.1	1.58e-305	1.39e-305
MA0788.1	POU3F3	MA0788.1	1.64e-305	1.44e-305
MA0501.1	MAF::NFE2	MA0501.1	1.68e-305	1.46e-305
MA0496.3	MAFK	MA0496.3	1.77e-305	1.56e-305
MA1633.2	BACH1	MA1633.2	1.89e-305	1.65e-305
MA0153.2	HNF1B	MA0153.2	1.99e-305	1.74e-305
MA0490.2	JUNB	MA0490.2	2.13e-305	1.86e-305
MA0655.1	JDP2	MA0655.1	2.14e-305	1.86e-305
MA1101.2	BACH2	MA1101.2	2.17e-305	1.89e-305
MA0046.2	HNF1A	MA0046.2	2.16e-305	1.89e-305
MA0477.2	FOSL1	MA0477.2	2.29e-305	2.01e-305
MA0791.1	POU4F3	MA0791.1	2.37e-305	2.07e-305
MA0099.3	FOS::JUN	MA0099.3	2.4e-305	2.11e-305
MA1134.1	FOS::JUNB	MA1134.1	2.81e-305	2.45e-305
MA0491.2	JUND	MA0491.2	3.13e-305	2.75e-305
MA0886.1	EMX2	MA0886.1	3.15e-305	2.75e-305
MA1132.1	JUN::JUNB	MA1132.1	3.16e-305	2.79e-305
MA0681.2	PHOX2B	MA0681.2	3.32e-305	2.9e-305
MA1634.1	BATF	MA1634.1	3.66e-305	3.22e-305
MA1113.2	PBX2	MA1113.2	3.86e-305	3.37e-305
MA0902.2	HOXB2	MA0902.2	4.01e-305	3.5e-305
MA0786.1	POU3F1	MA0786.1	4.17e-305	3.65e-305
MA1639.1	MEIS1	MA1639.1	4.24e-305	3.74e-305
MA1115.1	POU5F1	MA1115.1	4.34e-305	3.79e-305
MA0462.2	BATF::JUN	MA0462.2	4.38e-305	3.81e-305
MA0676.1	Nr2e1	MA0676.1	4.68e-305	4.09e-305
MA1141.1	FOS::JUND	MA1141.1	5.32e-305	4.64e-305
MA0846.1	FOXC2	MA0846.1	5.57e-305	4.86e-305
MA0476.1	FOS	MA0476.1	5.63e-305	4.9e-305
MA1928.1	BNC2	MA1928.1	5.86e-305	5.16e-305
MA1144.1	FOSL2::JUND	MA1144.1	5.93e-305	5.22e-305
MA1137.1	FOSL1::JUNB	MA1137.1	6.36e-305	5.54e-305
MA0679.2	ONECUT1	MA0679.2	7.01e-305	6.12e-305
MA0787.1	POU3F2	MA0787.1	7.21e-305	6.3e-305
MA0489.2	Jun	MA0489.2	7.2e-305	6.34e-305
MA0785.1	POU2F1	MA0785.1	7.29e-305	6.37e-305
MA1487.2	FOXE1	MA1487.2	7.53e-305	6.58e-305
MA0789.1	POU3F4	MA0789.1	7.6e-305	6.64e-305
MA0841.1	NFE2	MA0841.1	7.56e-305	6.65e-305
MA1640.1	MEIS2	MA1640.1	7.76e-305	6.78e-305
MA1988.1	Atf3	MA1988.1	8.29e-305	7.3e-305
MA1138.1	FOSL2::JUNB	MA1138.1	8.36e-305	7.36e-305
MA0835.2	BATF3	MA0835.2	8.75e-305	7.62e-305
MA1128.1	FOSL1::JUN	MA1128.1	9.06e-305	7.9e-305
MA0478.1	FOSL2	MA0478.1	9.16999999999999e-305	8.07e-305
MA0790.1	POU4F1	MA0790.1	9.46e-305	8.26e-305
MA0591.1	Bach1::Mafk	MA0591.1	9.65e-305	8.43e-305
MA0150.2	Nfe2l2	MA0150.2	9.69999999999999e-305	8.45e-305
MA0142.1	Pou5f1::Sox2	MA0142.1	9.81e-305	8.57e-305
MA0792.1	POU5F1B	MA0792.1	9.90999999999999e-305	8.66e-305
MA0627.2	POU2F3	MA0627.2	9.99999999999999e-306	8.76e-305
MA0089.2	MAFG::NFE2L1	MA0089.2	1.05e-305	9.14999999999999e-305
MA1135.1	FOSB::JUNB	MA1135.1	1.08e-305	9.51999999999999e-305
MA0845.1	FOXB1	MA0845.1	1.09e-305	9.53e-305
MA1978.1	ZNF354A	MA1978.1	1.1e-305	9.57e-305
MA1143.1	FOSL1::JUND	MA1143.1	7e-303	6.11e-300
MA0032.2	FOXC1	MA0032.2	1.43e-295	1.25e-292
MA1963.1	SATB1	MA1963.1	3.33e-294	2.92e-291
MA0628.1	POU6F1	MA0628.1	4.21e-291	3.68e-288
MA0041.2	FOXD3	MA0041.2	1.21e-286	1.06e-283
MA1124.1	ZNF24	MA1124.1	1.62e-281	1.42e-278
MA0611.2	Dux	MA0611.2	2.29e-274	2e-271
MA0715.1	PROP1	MA0715.1	8.64e-270	7.56e-267
MA0851.1	Foxj3	MA0851.1	4.74e-269	4.14e-266
MA1471.1	BARX2	MA1471.1	3.05e-267	2.67e-264
MA0084.1	SRY	MA0084.1	9.72999999999999e-267	8.51e-264
MA1606.1	Foxf1	MA1606.1	1.23e-266	1.08e-263
MA1603.1	Dmrt1	MA1603.1	1.65e-266	1.44e-263
MA0148.4	FOXA1	MA0148.4	1.73e-266	1.51e-263
MA1607.1	Foxl2	MA1607.1	8.15e-266	7.12e-263
MA0713.1	PHOX2A	MA0713.1	1.06e-265	9.26e-263
MA1974.1	ZNF211	MA1974.1	2.44e-265	2.13e-262
MA0052.4	MEF2A	MA0052.4	3.03e-265	2.65e-262
MA0025.2	NFIL3	MA0025.2	2.4e-264	2.1e-261
MA1549.1	POU6F1	MA1549.1	3.71e-263	3.25e-260
MA0602.1	Arid5a	MA0602.1	3.46e-262	3.02e-259
MA0793.1	POU6F2	MA0793.1	1.66e-258	1.45e-255
MA0601.1	Arid3b	MA0601.1	1.18e-257	1.03e-254
MA0612.2	EMX1	MA0612.2	6.8e-257	5.95e-254
MA0722.1	VAX1	MA0722.1	3.41e-255	2.98e-252
MA0847.3	FOXD2	MA0847.3	1.32e-252	1.15e-249
MA0901.2	HOXB13	MA0901.2	6.73e-251	5.89e-248
MA0613.1	FOXG1	MA0613.1	1.34e-246	1.17e-243
MA0910.2	HOXD8	MA0910.2	1.52e-245	1.33e-242
MA0723.2	VAX2	MA0723.2	4.09e-245	3.58e-242
MA0158.2	HOXA5	MA0158.2	7.57e-245	6.62e-242
MA0908.1	HOXD11	MA0908.1	1.07e-239	9.37e-237
MA0495.3	MAFF	MA0495.3	2.34e-238	2.04e-235
MA0710.1	NOTO	MA0710.1	2.47e-238	2.16e-235
MA1502.1	HOXB8	MA1502.1	3.27e-238	2.86e-235
MA1636.1	CEBPG	MA1636.1	6.29e-238	5.49e-235
MA0706.1	MEOX2	MA0706.1	3e-236	2.63e-233
MA0614.1	Foxj2	MA0614.1	2.71e-234	2.37e-231
MA0707.2	MNX1	MA0707.2	7.25e-230	6.34e-227
MA0031.1	FOXD1	MA0031.1	2.68e-225	2.34e-222
MA0849.1	FOXO6	MA0849.1	1.4e-224	1.23e-221
MA0724.1	VENTX	MA0724.1	1.82e-223	1.59e-220
MA0700.2	LHX2	MA0700.2	1.02e-222	8.92e-220
MA0047.3	FOXA2	MA0047.3	3.58e-222	3.13e-219
MA0043.3	HLF	MA0043.3	3.01e-221	2.63e-218
MA0132.2	PDX1	MA0132.2	3.46e-221	3.02e-218
MA0497.1	MEF2C	MA0497.1	4.47e-221	3.91e-218
MA0903.1	HOXB3	MA0903.1	3.25e-220	2.84e-217
MA1505.1	HOXC8	MA1505.1	4.87e-220	4.25e-217
MA0465.2	CDX2	MA0465.2	2.39e-219	2.09e-216
MA1495.1	HOXA1	MA1495.1	3.38e-218	2.95e-215
MA1152.1	SOX15	MA1152.1	3.74e-218	3.27e-215
MA0654.1	ISX	MA0654.1	8.74999999999999e-217	7.65e-214
MA0042.2	FOXI1	MA0042.2	9.62999999999999e-217	8.42e-214
MA1125.1	ZNF384	MA1125.1	1.36e-216	1.19e-213
MA0675.1	NKX6-2	MA0675.1	5.76e-216	5.04e-213
MA0035.4	GATA1	MA0035.4	3.12e-215	2.72e-212
MA1479.1	DMRTC2	MA1479.1	1.25e-214	1.09e-211
MA0674.1	NKX6-1	MA0674.1	1.88e-214	1.65e-211
MA0661.1	MEOX1	MA0661.1	5.7e-214	4.98e-211
MA0033.2	FOXL1	MA0033.2	2.06e-209	1.8e-206
MA0122.3	Nkx3-2	MA0122.3	4.12e-208	3.6e-205
MA0905.1	HOXC10	MA0905.1	5.01e-205	4.38e-202
MA0701.2	LHX9	MA0701.2	2.84e-204	2.48e-201
MA1530.1	NKX6-3	MA1530.1	4.82e-204	4.21e-201
MA1463.1	ARGFX	MA1463.1	4.94e-204	4.32e-201
MA0718.1	RAX	MA0718.1	3.32e-203	2.9e-200
MA0848.1	FOXO4	MA0848.1	3.57e-203	3.12e-200
MA1489.1	FOXN3	MA1489.1	5.13e-203	4.48e-200
MA0630.1	SHOX	MA0630.1	1.55e-202	1.36e-199
MA0102.4	CEBPA	MA0102.4	1.81e-202	1.58e-199
MA0650.3	Hoxa13	MA0650.3	2.63e-202	2.3e-199
MA0878.3	CDX1	MA0878.3	1.93e-199	1.68e-196
MA1519.1	LHX5	MA1519.1	2.79e-199	2.44e-196
MA0682.2	PITX1	MA0682.2	3.07e-198	2.68e-195
MA0904.2	HOXB5	MA0904.2	3.89e-198	3.4e-195
MA0912.2	HOXD3	MA0912.2	2.04e-197	1.78e-194
MA1962.1	POU2F1::SOX2	MA1962.1	2.42e-197	2.12e-194
MA0899.1	HOXA10	MA0899.1	1.87e-196	1.63e-193
MA0644.2	ESX1	MA0644.2	8.66999999999999e-196	7.58e-193
MA0658.1	LHX6	MA0658.1	5.02e-195	4.39e-192
MA1481.1	DRGX	MA1481.1	9.9e-195	8.65e-192
MA0075.3	PRRX2	MA0075.3	1.01e-194	8.82e-192
MA0909.3	Hoxd13	MA0909.3	2.72e-194	2.38e-191
MA0913.2	HOXD9	MA0913.2	3.79e-194	3.32e-191
MA0725.1	VSX1	MA0725.1	1.54e-193	1.35e-190
MA1480.1	DPRX	MA1480.1	6.76e-192	5.91e-189
MA0709.1	Msx3	MA0709.1	6.05e-191	5.29e-188
MA1104.2	GATA6	MA1104.2	2.8e-190	2.45e-187
MA1970.1	TRPS1	MA1970.1	6.98e-188	6.1e-185
MA0151.1	Arid3a	MA0151.1	1.83e-187	1.6e-184
MA0716.1	PRRX1	MA0716.1	2.43e-187	2.12e-184
MA0833.2	ATF4	MA0833.2	7.56e-187	6.6e-184
MA0125.1	Nobox	MA0125.1	1.51e-186	1.32e-183
MA0108.2	TBP	MA0108.2	1.66e-185	1.45e-182
MA0892.1	GSX1	MA0892.1	6.9e-185	6.03e-182
MA1577.1	TLX2	MA1577.1	3.16e-184	2.76e-181
MA0880.1	Dlx3	MA0880.1	4.61e-183	4.03e-180
MA1103.2	FOXK2	MA1103.2	4.91e-183	4.29e-180
MA0027.2	EN1	MA0027.2	1.53e-182	1.34e-179
MA1499.1	HOXB4	MA1499.1	1.73e-182	1.51e-179
MA0882.1	DLX6	MA0882.1	4.44e-182	3.88e-179
MA0868.2	SOX8	MA0868.2	7.1e-182	6.21e-179
MA0726.1	VSX2	MA0726.1	7.92e-182	6.92e-179
MA0068.2	PAX4	MA0068.2	7.54e-181	6.59e-178
MA1563.2	SOX18	MA1563.2	1.24e-180	1.08e-177
MA0704.1	Lhx4	MA0704.1	1.34e-180	1.17e-177
MA0881.1	Dlx4	MA0881.1	3.86e-180	3.37e-177
MA0036.3	GATA2	MA0036.3	2.91e-179	2.54e-176
MA0143.4	SOX2	MA0143.4	3.52e-179	3.07e-176
MA0836.2	CEBPD	MA0836.2	9.95e-179	8.7e-176
MA0875.1	BARX1	MA0875.1	4.53e-177	3.96e-174
MA0481.3	FOXP1	MA0481.3	8.11e-177	7.09e-174
MA1683.1	FOXA3	MA1683.1	2.62e-175	2.29e-172
MA0040.1	Foxq1	MA0040.1	2.46e-174	2.15e-171
MA0755.1	CUX2	MA0755.1	3.54e-174	3.09e-171
MA0077.1	SOX9	MA0077.1	7.81e-174	6.82e-171
MA0890.1	GBX2	MA0890.1	2.1e-173	1.83e-170
MA0720.1	Shox2	MA0720.1	1.09e-171	9.51e-169
MA0721.1	UNCX	MA0721.1	1.11e-171	9.66e-169
MA0898.1	Hmx3	MA0898.1	7.7e-171	6.73e-168
MA0894.1	HESX1	MA0894.1	7.63e-170	6.67e-167
MA0717.1	RAX2	MA0717.1	8.06e-169	7.04e-166
MA0157.3	Foxo3	MA0157.3	8.09e-169	7.07e-166
MA0666.2	MSX1	MA0666.2	2.86e-168	2.5e-165
MA0634.1	ALX3	MA0634.1	7.52e-166	6.58e-163
MA0900.2	HOXA2	MA0900.2	1.61e-165	1.4e-162
MA0874.1	Arx	MA0874.1	2.08e-165	1.82e-162
MA0854.1	Alx1	MA0854.1	1.01e-163	8.85e-161
MA0885.2	Dlx2	MA0885.2	7.14e-163	6.24e-160
MA1657.1	ZNF652	MA1657.1	8.97e-163	7.84e-160
MA0662.1	MIXL1	MA0662.1	2.55e-162	2.23e-159
MA0876.1	BSX	MA0876.1	2.57e-162	2.25e-159
MA0683.1	POU4F2	MA0683.1	1.55e-161	1.35e-158
MA1476.2	Dlx5	MA1476.2	6.37e-161	5.57e-158
MA1709.1	ZIM3	MA1709.1	6.52e-161	5.7e-158
MA0757.1	ONECUT3	MA0757.1	1.61e-160	1.41e-157
MA0911.1	Hoxa11	MA0911.1	7.84e-159	6.85e-156
MA0889.1	GBX1	MA0889.1	1.16e-158	1.01e-155
MA0853.1	Alx4	MA0853.1	2.14e-158	1.87e-155
MA0887.1	EVX1	MA0887.1	8.67e-158	7.58e-155
MA1504.1	HOXC4	MA1504.1	4.15e-156	3.62e-153
MA1498.2	HOXA7	MA1498.2	4.77e-152	4.17e-149
MA0705.1	Lhx8	MA0705.1	4.04e-151	3.53e-148
MA0708.2	MSX2	MA0708.2	5.91e-151	5.17e-148
MA1496.1	HOXA4	MA1496.1	2.09e-150	1.83e-147
MA0879.2	DLX1	MA0879.2	1.04e-149	9.05e-147
MA0907.1	HOXC13	MA0907.1	9.08e-149	7.94e-146
MA1623.1	Stat2	MA1623.1	2.46e-146	2.15e-143
MA0618.1	LBX1	MA0618.1	6.23e-146	5.45e-143
MA0895.1	HMBOX1	MA0895.1	1.02e-145	8.9e-143
MA0037.4	Gata3	MA0037.4	1.33e-144	1.16e-141
MA0070.1	PBX1	MA0070.1	6.84e-144	5.97e-141
MA0884.2	DUXA	MA0884.2	3.6e-142	3.15e-139
MA0754.2	CUX1	MA0754.2	3.75e-142	3.28e-139
MA0780.1	PAX3	MA0780.1	9.47e-142	8.28e-139
MA1120.1	SOX13	MA1120.1	1.16e-141	1.01e-138
MA0442.2	SOX10	MA0442.2	1.52e-141	1.33e-138
MA0852.2	FOXK1	MA0852.2	1.56e-141	1.36e-138
MA0635.1	BARHL2	MA0635.1	9.17e-139	8.02e-136
MA0678.1	OLIG2	MA0678.1	7.49e-137	6.54e-134
MA0642.2	EN2	MA0642.2	1.03e-136	9e-134
MA0891.1	GSC2	MA0891.1	1.06e-135	9.22e-133
MA1707.1	DMRTA1	MA1707.1	3.57e-134	3.12e-131
MA1500.1	HOXB6	MA1500.1	6.91e-133	6.04e-130
MA0648.1	GSC	MA0648.1	5.33e-132	4.66e-129
MA0699.1	LBX2	MA0699.1	9.67e-132	8.45e-129
MA0842.2	NRL	MA0842.2	2.6e-131	2.27e-128
MA0117.2	Mafb	MA0117.2	7.2e-131	6.29e-128
MA1518.2	Lhx1	MA1518.2	9.47e-131	8.28e-128
MA1507.1	HOXD4	MA1507.1	1.02e-130	8.93e-128
MA0050.3	Irf1	MA0050.3	5.53e-130	4.84e-127
MA0850.1	FOXP3	MA0850.1	4.47e-125	3.91e-122
MA1562.1	SOX14	MA1562.1	1.2e-124	1.05e-121
MA0769.2	TCF7	MA0769.2	1.61e-123	1.41e-120
MA1497.1	HOXA6	MA1497.1	2.41e-123	2.1e-120
MA0838.1	CEBPG	MA0838.1	3.19e-122	2.79e-119
MA0843.1	TEF	MA0843.1	7.38e-122	6.45e-119
MA0135.1	Lhx3	MA0135.1	2.37e-121	2.07e-118
MA0144.2	STAT3	MA0144.2	1.12e-119	9.77e-117
MA0482.2	GATA4	MA0482.2	1.58e-118	1.38e-115
MA1608.1	Isl1	MA1608.1	3.83e-118	3.35e-115
MA0621.1	mix-a	MA0621.1	2.56e-117	2.24e-114
MA0712.2	OTX2	MA0712.2	6.82e-117	5.97e-114
MA0523.1	TCF7L2	MA0523.1	7.94e-117	6.94e-114
MA0626.1	Npas2	MA0626.1	1.12e-116	9.76e-114
MA0606.2	Nfat5	MA0606.2	1.3e-115	1.13e-112
MA0593.1	FOXP2	MA0593.1	3.59e-115	3.13e-112
MA0893.2	GSX2	MA0893.2	9.27e-115	8.11e-112
MA0078.2	Sox17	MA0078.2	1.39e-114	1.22e-111
MA0030.1	FOXF2	MA0030.1	1.23e-113	1.08e-110
MA0514.2	Sox3	MA0514.2	2.19e-113	1.92e-110
MA1960.1	MGA::EVX1	MA1960.1	1.13e-111	9.91e-109
MA0906.1	HOXC12	MA0906.1	1.73e-111	1.52e-108
MA1729.1	ZNF680	MA1729.1	2.27e-109	1.99e-106
MA0480.2	Foxo1	MA0480.2	3.43e-109	3e-106
MA0809.2	TEAD4	MA0809.2	1.96e-107	1.72e-104
MA0140.2	GATA1::TAL1	MA0140.2	3.01e-107	2.63e-104
MA0106.3	TP53	MA0106.3	6.31e-106	5.51e-103
MA0766.2	GATA5	MA0766.2	6.37e-105	5.57e-102
MA0867.2	SOX4	MA0867.2	1.67e-103	1.46e-100
MA1588.1	ZNF136	MA1588.1	3.56e-103	3.11e-100
MA1134.1 (FOS::JUNB)	MEME-1	NDRTGASTCA	1.97e-305	1.2e-99
MA0896.1	Hmx1	MA0896.1	3.4e-102	2.97e-99
MA0520.1	Stat6	MA0520.1	9.49e-102	8.3e-99
MA1478.1	DMRTA2	MA1478.1	5.52e-100	4.82e-97
MA0888.1	EVX2	MA0888.1	1.47e-98	1.29e-95
MA0639.1	DBP	MA0639.1	1.96e-96	1.71e-93
MA0897.1	Hmx2	MA0897.1	2.57e-95	2.25e-92
MA0468.1	DUX4	MA0468.1	2.97e-95	2.59e-92
MA0768.2	Lef1	MA0768.2	7.38e-94	6.45e-91
MA0883.1	Dmbx1	MA0883.1	1.24e-93	1.08e-90
MA0515.1	Sox6	MA0515.1	1.63e-93	1.43e-90
MA0629.1	Rhox11	MA0629.1	2.37e-93	2.07e-90
MA1501.1	HOXB7	MA1501.1	2.58e-93	2.25e-90
MA1503.1	HOXB9	MA1503.1	2.24e-89	1.96e-86
MA0018.4	CREB1	MA0018.4	2.34e-89	2.05e-86
MA0784.2	POU1F1	MA0784.2	3.49e-89	3.05e-86
MA0483.1	Gfi1B	MA0483.1	4.77e-89	4.17e-86
MA0479.1	FOXH1	MA0479.1	9.58e-89	8.38e-86
MA0914.1	ISL2	MA0914.1	2.25e-87	1.97e-84
MA0837.2	CEBPE	MA0837.2	5.29e-86	4.62e-83
MA1119.1	SIX2	MA1119.1	5.82e-86	5.09e-83
MA0702.2	LMX1A	MA0702.2	1.39e-85	1.21e-82
MA0631.1	Six3	MA0631.1	1.4e-85	1.22e-82
MA1632.1	ATF2	MA1632.1	1.03e-83	8.99e-81
MA1150.1	RORB	MA1150.1	2.39e-82	2.09e-79
MA0711.1	OTX1	MA0711.1	1.3e-81	1.14e-78
MA0714.1	PITX3	MA0714.1	3.69e-81	3.22e-78
MA0467.2	Crx	MA0467.2	1.12e-80	9.76e-78
MA1139.1	FOSL2::JUNB	MA1139.1	2.93e-80	2.56e-77
MA1561.1	SOX12	MA1561.1	4.82e-80	4.21e-77
MA0095.3	Yy1	MA0095.3	1.48e-79	1.3e-76
MA0087.2	Sox5	MA0087.2	5.68e-79	4.96e-76
MA0827.1	OLIG3	MA0827.1	1.3e-78	1.14e-75
MA0693.3	Vdr	MA0693.3	1.46e-75	1.28e-72
MA1580.1	ZBTB32	MA1580.1	7.45e-75	6.51e-72
MA0461.2	Atoh1	MA0461.2	4.75e-74	4.15e-71
MA0038.2	GFI1	MA0038.2	4.19e-73	3.66e-70
MA1126.1	FOS::JUN	MA1126.1	3.09e-72	2.7e-69
MA1131.1	FOSL2::JUN	MA1131.1	2.57e-71	2.25e-68
MA1118.1	SIX1	MA1118.1	5.54e-70	4.84e-67
MA0063.2	NKX2-5	MA0063.2	9.72e-70	8.49e-67
MA0873.1	HOXD12	MA0873.1	1.16e-69	1.01e-66
MA0877.3	BARHL1	MA0877.3	1.6e-69	1.4e-66
MA0507.2	POU2F2	MA0507.2	2.06e-67	1.8e-64
MA1520.1	MAF	MA1520.1	2.91e-67	2.55e-64
MA0152.2	Nfatc2	MA0152.2	6.03e-67	5.27e-64
MA0090.3	TEAD1	MA0090.3	1.29e-66	1.13e-63
MA0782.2	PKNOX1	MA0782.2	4.03e-66	3.52e-63
MA0861.1	TP73	MA0861.1	4.52e-66	3.95e-63
MA1506.1	HOXD10	MA1506.1	2.95e-65	2.58e-62
MA0689.1	TBX20	MA0689.1	1.5e-64	1.31e-61
MA1127.1	FOSB::JUN	MA1127.1	3.89e-64	3.4e-61
MA0620.3	MITF	MA0620.3	1.61e-63	1.41e-60
MA0869.2	Sox11	MA0869.2	2.22e-62	1.94e-59
MA0029.1	Mecom	MA0029.1	3.19e-62	2.79e-59
MA0525.2	TP63	MA0525.2	8.03e-62	7.02e-59
MA1991.1	Hnf1A	MA1991.1	2.34e-60	2.05e-57
MA1112.2	NR4A1	MA1112.2	1.67e-59	1.46e-56
MA0772.1	IRF7	MA0772.1	2.03e-59	1.78e-56
MA1994.1	Nkx2-1	MA1994.1	6.51e-58	5.69e-55
MA1125.1 (ZNF384)	MEME-2	TTTTTTTTTTTTTTT	7.38e-294	3.2e-54
MA0596.1	SREBF2	MA0596.1	7.77e-57	6.79e-54
MA1473.1	CDX4	MA1473.1	1.01e-56	8.83e-54
MA0069.1	PAX6	MA0069.1	1.4e-55	1.23e-52
MA0624.2	Nfatc1	MA0624.2	1.78e-55	1.55e-52
MA1145.1	FOSL2::JUND	MA1145.1	2.7e-55	2.36e-52
MA0808.1	TEAD3	MA0808.1	1.58e-54	1.38e-51
MA0817.1	BHLHE23	MA0817.1	3.45e-53	3.02e-50
MA0466.3	CEBPB	MA0466.3	6.53e-53	5.7e-50
MA1718.1	ZNF8	MA1718.1	1.15e-52	1.01e-49
MA0651.2	HOXC11	MA0651.2	2.46e-52	2.15e-49
MA1956.1	FOXO1::FLI1	MA1956.1	4.41e-52	3.86e-49
MA1151.1	RORC	MA1151.1	2.94e-51	2.57e-48
MA0492.1	JUND	MA0492.1	4.9e-51	4.28e-48
MA1720.1	ZNF85	MA1720.1	1.44e-50	1.26e-47
MA0773.1	MEF2D	MA0773.1	1.77e-50	1.55e-47
MA0619.1	LIN54	MA0619.1	2.37e-50	2.07e-47
MA1105.2	GRHL2	MA1105.2	5.87e-50	5.13e-47
MA0517.1	STAT1::STAT2	MA0517.1	1.37e-49	1.2e-46
MA1953.1	FOXO1::ELF1	MA1953.1	2.22e-49	1.94e-46
MA1975.1	ZNF214	MA1975.1	6.42e-49	5.61e-46
MA1129.1	FOSL1::JUN	MA1129.1	8.95e-49	7.82e-46
MA0826.1	OLIG1	MA0826.1	1.31e-48	1.15e-45
MA0488.1	JUN	MA0488.1	5.49e-47	4.8e-44
MA0124.2	Nkx3-1	MA0124.2	9.1e-47	7.96e-44
MA0829.2	SREBF1	MA0829.2	1.05e-46	9.21e-44
MA1108.2	MXI1	MA1108.2	1.06e-46	9.29e-44
MA0756.2	ONECUT2	MA0756.2	3.6e-46	3.15e-43
MA0594.2	HOXA9	MA0594.2	4.83e-46	4.22e-43
MA0660.1	MEF2B	MA0660.1	5.97e-46	5.21e-43
MA1989.1	Bcl11B	MA1989.1	8.43e-46	7.37e-43
MA1534.1	NR1I3	MA1534.1	8.93e-46	7.81e-43
MA0093.3	USF1	MA0093.3	2.6e-45	2.27e-42
MA1547.2	PITX2	MA1547.2	3.1e-42	2.71e-39
2-ATRYAT	STREME-2	2-ATRYAT	3.94e-305	2.82e-39
MA1593.1	ZNF317	MA1593.1	6.77e-41	5.91e-38
MA1980.1	ZNF418	MA1980.1	3.7e-39	3.24e-36
MA1523.1	MSANTD3	MA1523.1	3.74e-39	3.27e-36
MA0595.1	SREBF1	MA0595.1	2.25e-38	1.97e-35
MA1421.1	TCF7L1	MA1421.1	2.59e-38	2.26e-35
MA0647.1	GRHL1	MA0647.1	4.04e-37	3.53e-34
MA1592.1	ZNF274	MA1592.1	4.2e-37	3.67e-34
MA1136.1	FOSB::JUNB	MA1136.1	2.04e-36	1.78e-33
MA0684.2	RUNX3	MA0684.2	3.58e-35	3.13e-32
MA1570.1	TFAP4	MA1570.1	4.87e-35	4.26e-32
MA1121.1	TEAD2	MA1121.1	4.92e-35	4.3e-32
MA1952.1	FOXJ2::ELF1	MA1952.1	9.13e-35	7.98e-32
MA0743.2	SCRT1	MA0743.2	1.08e-34	9.4e-32
MA0518.1	Stat4	MA0518.1	3.87e-34	3.38e-31
MA0719.1	RHOXF1	MA0719.1	4.19e-34	3.66e-31
MA1111.1	NR2F2	MA1111.1	3.63e-33	3.18e-30
MA0137.3	STAT1	MA0137.3	3.74e-33	3.27e-30
MA1618.1	Ptf1a	MA1618.1	1.18e-32	1.03e-29
MA0687.1	SPIC	MA0687.1	1.51e-32	1.32e-29
MA0840.1	Creb5	MA0840.1	1.94e-32	1.69e-29
MA2001.1	Six4	MA2001.1	2.57e-32	2.25e-29
MA0164.1	Nr2e3	MA0164.1	3.14e-32	2.75e-29
MA0148.4 (FOXA1)	STREME-3	3-AAACAT	9.96e-305	1.14e-28
MA0485.2	HOXC9	MA0485.2	1.59e-31	1.39e-28
MA1644.1	NFYC	MA1644.1	1.67e-28	1.46e-25
MA1585.1	ZKSCAN1	MA1585.1	1.84e-27	1.61e-24
MA0623.2	NEUROG1	MA0623.2	2.36e-27	2.06e-24
MA0703.2	LMX1B	MA0703.2	1.99e-26	1.74e-23
MA1137.1 (FOSL1::JUNB)	STREME-4	4-ATGACTA	2.59e-305	6e-22
MA0072.1	RORA	MA0072.1	8.03e-25	7.01e-22
MA0669.1	NEUROG2	MA0669.1	8.84e-25	7.72e-22
MA1521.1	MAFA	MA1521.1	1.18e-24	1.03e-21
MA0508.3	PRDM1	MA0508.3	5.89e-24	5.15e-21
MA0041.2 (FOXD3)	STREME-5	5-AAATAA	3.75e-210	9.88e-21
MA1524.2	Msgn1	MA1524.2	1.45e-23	1.27e-20
MA0607.2	BHLHA15	MA0607.2	3.42e-23	2.99e-20
MA0804.1	TBX19	MA0804.1	3.78e-23	3.3e-20
MA0498.2	MEIS1	MA0498.2	6.75e-23	5.9e-20
MA1123.2	TWIST1	MA1123.2	1.68e-22	1.47e-19
MA0800.1	EOMES	MA0800.1	4.57e-21	3.99e-18
MA0519.1	Stat5a::Stat5b	MA0519.1	5.86e-21	5.12e-18
MA1624.1	Stat5a	MA1624.1	1.88e-20	1.64e-17
MA0494.1	Nr1h3::Rxra	MA0494.1	2.4e-20	2.1e-17
MA1594.1	ZNF382	MA1594.1	5.19e-20	4.53e-17
MA1547.2 (PITX2)	MEME-3	GCCTGTAATCCCAGC	1.9e-55	4.6e-16
6-ATTACA	STREME-6	6-ATTACA	2.12e-224	6.37e-16
MA1133.1	JUN::JUNB	MA1133.1	9.86e-19	8.62e-16
MA1148.1	PPARA::RXRA	MA1148.1	4.78e-18	4.18e-15
TGTGTRTGTGTGTGT	MEME-4	TGTGTRTGTGTGTGT	5.63e-18	5.4e-15
MA0802.1	TBR1	MA0802.1	1.19e-17	1.04e-14
MA1995.1	Npas4	MA1995.1	1.9e-17	1.66e-14
MA0698.1	ZBTB18	MA0698.1	2.81e-17	2.46e-14
MA0610.1	DMRT3	MA0610.1	5.11e-17	4.47e-14
7-WAGAGAW	STREME-7	7-WAGAGAW	2.09e-272	1.02e-13
MA1587.1	ZNF135	MA1587.1	2.62e-16	2.29e-13
MA0114.4	HNF4A	MA0114.4	1.31e-15	1.15e-12
MA0744.2	SCRT2	MA0744.2	4.1e-15	3.58e-12
MA0484.2	HNF4G	MA0484.2	4.28e-15	3.74e-12
MA0019.1	Ddit3::Cebpa	MA0019.1	7.23e-15	6.32e-12
MA0818.2	BHLHE22	MA0818.2	1.31e-14	1.14e-11
8-BTTSAAV	STREME-8	8-BTTSAAV	3.32e-219	2.65e-11
MA1114.1	PBX3	MA1114.1	5.01e-14	4.38e-11
MA0463.2	BCL6	MA0463.2	1.54e-13	1.34e-10
MA0688.1	TBX2	MA0688.1	4.77e-13	4.17e-10
MA0770.1	HSF2	MA0770.1	9e-13	7.86e-10
MA0071.1	RORA	MA0071.1	1.8e-12	1.57e-09
MA1596.1 (ZNF460)	MEME-5	TTTGGGAGGCYGAGG	9.78e-40	1.8e-09
MA1525.2	NFATC4	MA1525.2	9.09e-12	7.94e-09
MA0656.1	JDP2	MA0656.1	1.39e-11	1.22e-08
MA1955.1	FOXO1::ELK3	MA1955.1	1.62e-11	1.42e-08
MA0141.3	ESRRB	MA0141.3	2.06e-11	1.8e-08
9-AAWWTT	STREME-9	9-AAWWTT	3.17e-188	3.66e-08
MA0160.2	NR4A2	MA0160.2	6.65e-11	5.82e-08
MA0805.1	TBX1	MA0805.1	1.42e-10	1.24e-07
MA0066.1	PPARG	MA0066.1	3.11e-10	2.72e-07
MA1155.1	ZSCAN4	MA1155.1	3.81e-10	3.33e-07
MA0866.1	SOX21	MA0866.1	5.77e-10	5.04e-07
MA1645.1	NKX2-2	MA1645.1	7.49e-10	6.55e-07
MA1996.1	Nr1H2	MA1996.1	1.46e-09	1.27e-06
MA1468.1	ATOH7	MA1468.1	1.63e-09	1.43e-06
MA0486.2	HSF1	MA0486.2	1.83e-09	1.6e-06
MA0002.2	Runx1	MA0002.2	2.46e-09	2.15e-06
MA1596.1	ZNF460	MA1596.1	3.92e-09	3.43e-06
MA0728.1	Nr2F6	MA0728.1	6.05e-09	5.29e-06
MA0060.3	NFYA	MA0060.3	7.93e-09	6.93e-06
MA0828.2	SREBF2	MA0828.2	9.51e-09	8.31e-06
MA1714.1	ZNF675	MA1714.1	1.43e-08	1.25e-05
MA0831.3	TFE3	MA0831.3	1.56e-08	1.37e-05
MA1625.1	Stat5b	MA1625.1	2.37e-08	2.07e-05
MA0476.1 (FOS)	STREME-10	10-TGANTCA	7.22e-305	2.37e-05
MA0108.2 (TBP)	STREME-11	11-TWTAWA	2.2e-260	8.9e-05
MA1546.1	PAX3	MA1546.1	3.4e-07	0.000297
MA0673.1	NKX2-8	MA0673.1	3.88e-07	0.000339
MA0870.1	Sox1	MA0870.1	4.78e-07	0.000418
MA0797.1	TGIF2	MA0797.1	5.24e-07	0.000458
MA0051.1	IRF2	MA0051.1	5.54e-07	0.000485
MA1973.1 (ZKSCAN3)	STREME-12	12-CCAGCCTGGGCAACA	3.44e-42	0.000486
MA1716.1 (ZNF76)	STREME-13	13-GCACTTTGGGAGGC	4.92e-29	0.000877
MA0130.1	ZNF354C	MA0130.1	1.03e-06	0.000897
MA1541.1	NR6A1	MA1541.1	1.06e-06	0.00093
MA1943.1	ETV2::HOXB13	MA1943.1	1.34e-06	0.00117
MA0653.1	IRF9	MA0653.1	1.92e-06	0.00167
MA0859.1	Rarg	MA0859.1	2.23e-06	0.00195
MA1642.1	NEUROG2	MA1642.1	2.61e-06	0.00228
MA1467.2	Atoh1	MA1467.2	2.84e-06	0.00248
MA1419.1	IRF4	MA1419.1	2.94e-06	0.00257
MA0511.2	RUNX2	MA0511.2	3.07e-06	0.00268
MA0009.2	TBXT	MA0009.2	3.33e-06	0.00291
MA1950.1	FLI1::FOXI1	MA1950.1	4.38e-06	0.00383
MA1937.1	ERF::HOXB13	MA1937.1	5.36e-06	0.00469
14-AGTAGCTGG	STREME-14	14-AGTAGCTGG	1.83e-23	0.00473
MA1647.2	Prdm4	MA1647.2	5.44e-06	0.00476
MA0652.1	IRF8	MA0652.1	8.73e-06	0.00763
MA1638.1	HAND2	MA1638.1	9.47e-06	0.00828
MA1596.1 (ZNF460)	STREME-15	15-CCTGCCTCAGCCTCC	3.15e-29	0.00982
MA0691.1	TFAP4	MA0691.1	1.42e-05	0.0124
MA1973.1 (ZKSCAN3)	MEME-6	TGTYGCCCAGGCTGG	6.21e-35	0.013
MA0664.1	MLXIPL	MA0664.1	1.49e-05	0.013
MA1949.1	FLI1::DRGX	MA1949.1	1.57e-05	0.0137
MA0592.3	ESRRA	MA0592.3	1.64e-05	0.0143
MA1596.1 (ZNF460)	STREME-17	17-ACCTCTGCCTCCCAG	8.58e-28	0.0245
MA1107.2 (KLF9)	STREME-16	16-CACACACAC	8.57e-24	0.0245
18-ACACAGGCACAC	STREME-18	18-ACACAGGCACAC	7.04e-29	0.0255
MA1989.1 (Bcl11B)	STREME-19	19-AAACCA	1.31e-88	0.027
MA0795.1	SMAD3	MA0795.1	3.18e-05	0.0278
MA1589.1	ZNF140	MA1589.1	3.45e-05	0.0302
20-AGTGCAGTG	STREME-20	20-AGTGCAGTG	5.1e-16	0.0303
MA0803.1 (TBX15)	STREME-21	21-ACACTCACAC	3.08e-09	0.0321
MA1579.1	ZBTB26	MA1579.1	4.26e-05	0.0373
MA0643.1	Esrrg	MA0643.1	4.86e-05	0.0425
MA1515.1 (KLF2)	STREME-22	22-CCACCACRCCCRGC	1.4e-37	0.0471
MA1990.1 (Gli1)	STREME-23	23-ACACACCACACACA	7.92e-09	0.0525
MA1990.1 (Gli1)	STREME-24	24-CACACCACACAC	5.81e-24	0.055
25-ACCCACACAC	STREME-25	25-ACCCACACAC	1.06e-14	0.0713
MA1973.1 (ZKSCAN3)	STREME-26	26-AGACCAGCCTGGSC	2.71e-34	0.154
MA0803.1 (TBX15)	STREME-27	27-AGGTGGGAGGAT	8.18e-27	4.34

ESR_opcl_xstreme %>% 
  dplyr::select(SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
  arrange(.,EVALUE) %>%
   dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  # dplyr::filter(., EVALUE<0.05) %>% 
  kable(., caption = "Enriched motifs  in ESR OC") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "800px")

Enriched motifs in ESR OC
SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
MA1125.1 (ZNF384)	MEME-1	AARWADAAAAAWAWW	1.73e-11	1e-13
MA1107.2 (KLF9)	MEME-2	GTGTGTRTGTGTGTG	0.075	3e-07
MA0789.1	POU3F4	MA0789.1	5.29e-08	4.48e-05
MA0787.1	POU3F2	MA0787.1	3.21e-07	0.000272
MA0063.2	NKX2-5	MA0063.2	4.29e-07	0.000363
MA0676.1	Nr2e1	MA0676.1	4.7e-07	0.000397
MA0507.2	POU2F2	MA0507.2	7.47e-06	0.00632
MA0792.1	POU5F1B	MA0792.1	8.05e-06	0.00681
MA1471.1	BARX2	MA1471.1	8.51e-06	0.0072
MA0788.1	POU3F3	MA0788.1	1.59e-05	0.0135
MA0913.2	HOXD9	MA0913.2	4.43e-05	0.0375
MA0790.1	POU4F1	MA0790.1	4.52e-05	0.0383
MA0465.2	CDX2	MA0465.2	4.76e-05	0.0403
1-AWATATWT	STREME-1	1-AWATATWT	7.55e-06	0.372
2-CCAAGCTACA	STREME-2	2-CCAAGCTACA	3.57e-10	1.38
MA1589.1 (ZNF140)	STREME-3	3-AATTCCATTCTCHMW	9.86e-13	3

LR lists

LR_open_10h_xstreme %>%
  dplyr::select(RANK,SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>%
  arrange(.,EVALUE) %>%
   dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>%
  # dplyr::filter(., EVALUE<0.05) %>%
  kable(., caption = "Enriched motifs in LR_open") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "800px")

Enriched motifs in LR_open
RANK	SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
18	MA0490.2	JUNB	MA0490.2	1.17e-305	1.01e-305
19	MA0462.2	BATF::JUN	MA0462.2	1.18e-305	1.01e-305
46	MA0611.2	Dux	MA0611.2	1.39e-305	1.2e-305
32	MA0501.1	MAF::NFE2	MA0501.1	1.56e-305	1.35e-305
12	MA1128.1	FOSL1::JUN	MA1128.1	1.67e-305	1.44e-305
30	MA0089.2	MAFG::NFE2L1	MA0089.2	1.7e-305	1.47e-305
15	MA0491.2	JUND	MA0491.2	1.93e-305	1.65e-305
11	MA1135.1	FOSB::JUNB	MA1135.1	2.01e-305	1.73e-305
37	MA1143.1	FOSL1::JUND	MA1143.1	2.05e-305	1.77e-305
42	MA1113.2	PBX2	MA1113.2	2.12e-305	1.82e-305
8	MA0489.2	Jun	MA0489.2	2.17e-305	1.87e-305
16	MA1988.1	Atf3	MA1988.1	2.18e-305	1.88e-305
39	MA1639.1	MEIS1	MA1639.1	2.28e-305	1.97e-305
10	MA1130.1	FOSL2::JUN	MA1130.1	2.53e-305	2.16e-305
29	MA1132.1	JUN::JUNB	MA1132.1	2.6e-305	2.22e-305
47	MA0790.1	POU4F1	MA0790.1	2.67e-305	2.3e-305
24	MA1137.1	FOSL1::JUNB	MA1137.1	2.69e-305	2.32e-305
20	MA1633.2	BACH1	MA1633.2	2.7e-305	2.33e-305
13	MA0099.3	FOS::JUN	MA0099.3	3.32e-305	2.86e-305
25	MA0655.1	JDP2	MA0655.1	3.8e-305	3.28e-305
7	MA1138.1	FOSL2::JUNB	MA1138.1	3.85e-305	3.32e-305
14	MA0478.1	FOSL2	MA0478.1	4.18e-305	3.61e-305
17	MA1634.1	BATF	MA1634.1	4.23e-305	3.65e-305
45	MA0591.1	Bach1::Mafk	MA0591.1	4.35e-305	3.75e-305
43	MA1640.1	MEIS2	MA1640.1	5.31e-305	4.57e-305
26	MA1142.1	FOSL1::JUND	MA1142.1	5.39e-305	4.6e-305
22	MA1928.1	BNC2	MA1928.1	5.36e-305	4.63e-305
6	MA0476.1	FOS	MA0476.1	5.91e-305	5.1e-305
21	MA0835.2	BATF3	MA0835.2	5.93e-305	5.12e-305
3	MA0477.2	FOSL1	MA0477.2	6.5e-305	5.61e-305
34	MA0659.3	Mafg	MA0659.3	6.55e-305	5.65e-305
31	MA0496.3	MAFK	MA0496.3	6.56e-305	5.66e-305
27	MA1101.2	BACH2	MA1101.2	6.8e-305	5.86e-305
28	MA0841.1	NFE2	MA0841.1	6.84e-305	5.9e-305
33	MA0150.2	Nfe2l2	MA0150.2	7.16e-305	6.18e-305
9	MA1144.1	FOSL2::JUND	MA1144.1	7.42e-305	6.4e-305
2	MA1134.1	FOS::JUNB	MA1134.1	7.72e-305	6.66e-305
1	MA1134.1 (FOS::JUNB)	STREME-1	1-DATGASTCATH	3.3e-305	6.67e-305
44	MA0791.1	POU4F3	MA0791.1	9.53e-305	8.21e-305
40	MA0676.1	Nr2e1	MA0676.1	1.05e-305	9.06e-305
4	MA1141.1	FOS::JUND	MA1141.1	1.08e-305	9.28e-305
49	MA0153.2	HNF1B	MA0153.2	8.77999999999999e-297	7.57e-294
50	MA0046.2	HNF1A	MA0046.2	1.92e-292	1.65e-289
52	MA0683.1	POU4F2	MA0683.1	3.21e-287	2.76e-284
53	MA0788.1	POU3F3	MA0788.1	7.61e-276	6.56e-273
54	MA0495.3	MAFF	MA0495.3	9.62999999999999e-276	8.3e-273
55	MA0845.1	FOXB1	MA0845.1	9.33999999999999e-273	8.05e-270
56	MA1549.1	POU6F1	MA1549.1	8.58e-270	7.39e-267
59	MA1974.1	ZNF211	MA1974.1	7.8e-261	6.73e-258
60	MA1978.1	ZNF354A	MA1978.1	5.02e-258	4.32e-255
61	MA0142.1	Pou5f1::Sox2	MA0142.1	6.22e-258	5.37e-255
62	MA1487.2	FOXE1	MA1487.2	1.96e-255	1.69e-252
63	MA0706.1	MEOX2	MA0706.1	3.46e-254	2.98e-251
64	MA0612.2	EMX1	MA0612.2	2.12e-253	1.82e-250
65	MA1502.1	HOXB8	MA1502.1	5.6e-253	4.82e-250
66	MA0681.2	PHOX2B	MA0681.2	1.82e-252	1.57e-249
67	MA0846.1	FOXC2	MA0846.1	9.56e-252	8.25e-249
68	MA0902.2	HOXB2	MA0902.2	2.45e-251	2.12e-248
69	MA0158.2	HOXA5	MA0158.2	1.01e-249	8.67999999999999e-247
70	MA0041.2	FOXD3	MA0041.2	3.55e-248	3.06e-245
71	MA0886.1	EMX2	MA0886.1	3.17e-246	2.73e-243
72	MA0910.2	HOXD8	MA0910.2	7.07e-246	6.1e-243
73	MA1124.1	ZNF24	MA1124.1	4.34e-244	3.75e-241
74	MA0904.2	HOXB5	MA0904.2	2.98e-239	2.57e-236
75	MA1530.1	NKX6-3	MA1530.1	3.1e-239	2.68e-236
76	MA1962.1	POU2F1::SOX2	MA1962.1	3.99e-239	3.44e-236
77	MA0912.2	HOXD3	MA0912.2	6.44e-239	5.55e-236
78	MA0680.2	Pax7	MA0680.2	2.82e-238	2.43e-235
79	MA0679.2	ONECUT1	MA0679.2	1.04e-234	8.97e-232
80	MA1495.1	HOXA1	MA1495.1	2.03e-234	1.75e-231
82	MA0661.1	MEOX1	MA0661.1	1.24e-229	1.07e-226
84	MA0148.4	FOXA1	MA0148.4	4.58e-229	3.95e-226
85	MA0025.2	NFIL3	MA0025.2	8.34e-229	7.19e-226
86	MA0628.1	POU6F1	MA0628.1	2.37e-228	2.04e-225
87	MA0047.3	FOXA2	MA0047.3	3.18e-228	2.74e-225
88	MA0032.2	FOXC1	MA0032.2	1.22e-227	1.05e-224
89	MA0627.2	POU2F3	MA0627.2	1.81e-226	1.56e-223
90	MA0785.1	POU2F1	MA0785.1	8.86e-225	7.64e-222
91	MA1115.1	POU5F1	MA1115.1	2.29e-223	1.98e-220
92	MA1636.1	CEBPG	MA1636.1	1.14e-222	9.84999999999999e-220
93	MA0787.1	POU3F2	MA0787.1	7.44e-221	6.41e-218
94	MA0722.1	VAX1	MA0722.1	1.57e-220	1.35e-217
95	MA0040.1	Foxq1	MA0040.1	2.69e-220	2.32e-217
96	MA0786.1	POU3F1	MA0786.1	7.85e-219	6.76e-216
97	MA0833.2	ATF4	MA0833.2	2.4e-215	2.07e-212
98	MA0132.2	PDX1	MA0132.2	2.54e-214	2.19e-211
99	MA1607.1	Foxl2	MA1607.1	5.72e-214	4.93e-211
100	MA0789.1	POU3F4	MA0789.1	9.53e-213	8.21e-210
101	MA0043.3	HLF	MA0043.3	7.64e-212	6.59e-209
102	MA0701.2	LHX9	MA0701.2	1.92e-211	1.65e-208
103	MA1606.1	Foxf1	MA1606.1	2.64e-211	2.28e-208
104	MA0851.1	Foxj3	MA0851.1	9.06e-211	7.8e-208
105	MA0710.1	NOTO	MA0710.1	2.35e-210	2.02e-207
106	MA0102.4	CEBPA	MA0102.4	3.9e-210	3.36e-207
107	MA1152.1	SOX15	MA1152.1	2.03e-209	1.75e-206
108	MA0900.2	HOXA2	MA0900.2	5.22e-209	4.5e-206
109	MA0793.1	POU6F2	MA0793.1	2.85e-204	2.46e-201
110	MA0613.1	FOXG1	MA0613.1	4.32e-204	3.73e-201
111	MA0847.3	FOXD2	MA0847.3	1.3e-203	1.12e-200
112	MA0602.1	Arid5a	MA0602.1	3.81e-203	3.29e-200
113	MA0614.1	Foxj2	MA0614.1	6.08e-202	5.24e-199
114	MA1499.1	HOXB4	MA1499.1	2.87e-201	2.47e-198
115	MA0792.1	POU5F1B	MA0792.1	5.63e-201	4.85e-198
116	MA1603.1	Dmrt1	MA1603.1	8.28e-200	7.14e-197
117	MA1471.1	BARX2	MA1471.1	1.76e-199	1.52e-196
118	MA0143.4	SOX2	MA0143.4	9.3e-198	8.01e-195
119	MA0903.1	HOXB3	MA0903.1	1.32e-197	1.14e-194
120	MA1963.1	SATB1	MA1963.1	2.93e-197	2.53e-194
121	MA0715.1	PROP1	MA0715.1	8.26e-197	7.12e-194
122	MA0481.3	FOXP1	MA0481.3	4.48e-195	3.86e-192
123	MA0723.2	VAX2	MA0723.2	8.01e-195	6.91e-192
124	MA0843.1	TEF	MA0843.1	4.78e-194	4.12e-191
125	MA1683.1	FOXA3	MA1683.1	4.37e-191	3.77e-188
126	MA0725.1	VSX1	MA0725.1	6.64e-191	5.73e-188
127	MA1103.2	FOXK2	MA1103.2	1.78e-190	1.54e-187
128	MA0875.1	BARX1	MA0875.1	1.43e-188	1.24e-185
129	MA0654.1	ISX	MA0654.1	2.23e-188	1.92e-185
130	MA0726.1	VSX2	MA0726.1	3.11e-188	2.68e-185
131	MA0084.1	SRY	MA0084.1	3.38e-188	2.92e-185
132	MA0884.2	DUXA	MA0884.2	1.4e-187	1.21e-184
133	MA0713.1	PHOX2A	MA0713.1	2.24e-187	1.93e-184
134	MA1505.1	HOXC8	MA1505.1	2.85e-186	2.45e-183
135	MA0905.1	HOXC10	MA0905.1	7.03e-186	6.06e-183
136	MA0675.1	NKX6-2	MA0675.1	7.08e-186	6.1e-183
137	MA0908.1	HOXD11	MA0908.1	1.72e-185	1.48e-182
138	MA1504.1	HOXC4	MA1504.1	1.39e-183	1.2e-180
139	MA0707.2	MNX1	MA0707.2	3.82e-183	3.29e-180
140	MA0507.2	POU2F2	MA0507.2	7.73e-183	6.66e-180
141	MA0630.1	SHOX	MA0630.1	1.13e-182	9.78e-180
142	MA1496.1	HOXA4	MA1496.1	1.82e-180	1.57e-177
143	MA1480.1	DPRX	MA1480.1	1.52e-179	1.31e-176
144	MA0077.1	SOX9	MA0077.1	7.18e-179	6.18e-176
145	MA0780.1	PAX3	MA0780.1	8.66e-179	7.46e-176
146	MA0784.2	POU1F1	MA0784.2	1.2e-178	1.03e-175
147	MA0639.1	DBP	MA0639.1	3.35e-178	2.89e-175
148	MA0031.1	FOXD1	MA0031.1	4.12e-178	3.56e-175
149	MA0117.2	Mafb	MA0117.2	2.13e-176	1.83e-173
150	MA0135.1	Lhx3	MA0135.1	8.25e-176	7.11e-173
151	MA0882.1	DLX6	MA0882.1	3.81e-175	3.29e-172
152	MA1479.1	DMRTC2	MA1479.1	2.05e-173	1.77e-170
155	MA0030.1	FOXF2	MA0030.1	5.7e-172	4.91e-169
156	MA0674.1	NKX6-1	MA0674.1	8.91e-171	7.68e-168
157	MA0658.1	LHX6	MA0658.1	2.19e-169	1.89e-166
158	MA0704.1	Lhx4	MA0704.1	9e-169	7.75e-166
159	MA0027.2	EN1	MA0027.2	5.74e-167	4.95e-164
160	MA0909.3	Hoxd13	MA0909.3	2.03e-166	1.75e-163
161	MA0878.3	CDX1	MA0878.3	4.52e-166	3.89e-163
162	MA0880.1	Dlx3	MA0880.1	1.24e-165	1.07e-162
163	MA0836.2	CEBPD	MA0836.2	1.98e-165	1.71e-162
164	MA0881.1	Dlx4	MA0881.1	7.71e-165	6.64e-162
165	MA0724.1	VENTX	MA0724.1	2.12e-164	1.83e-161
166	MA0650.3	Hoxa13	MA0650.3	1.31e-163	1.13e-160
167	MA0757.1	ONECUT3	MA0757.1	2.72e-163	2.35e-160
168	MA0157.3	Foxo3	MA0157.3	9.17e-163	7.91e-160
169	MA0075.3	PRRX2	MA0075.3	3.24e-162	2.79e-159
170	MA0052.4	MEF2A	MA0052.4	3.46e-162	2.98e-159
171	MA0849.1	FOXO6	MA0849.1	7.69e-162	6.63e-159
172	MA0070.1	PBX1	MA0070.1	5.64e-161	4.86e-158
173	MA1507.1	HOXD4	MA1507.1	8.31e-161	7.17e-158
174	MA1463.1	ARGFX	MA1463.1	8.94e-161	7.7e-158
175	MA0874.1	Arx	MA0874.1	2.45e-160	2.11e-157
176	MA0911.1	Hoxa11	MA0911.1	2.8e-160	2.41e-157
177	MA1500.1	HOXB6	MA1500.1	6.19e-160	5.34e-157
178	MA0644.2	ESX1	MA0644.2	9.57e-160	8.25e-157
180	MA0842.2	NRL	MA0842.2	3.28e-159	2.83e-156
181	MA0899.1	HOXA10	MA0899.1	3.86e-159	3.33e-156
182	MA0892.1	GSX1	MA0892.1	4.52e-159	3.89e-156
183	MA0868.2	SOX8	MA0868.2	2.14e-158	1.85e-155
184	MA0601.1	Arid3b	MA0601.1	2.22e-158	1.91e-155
185	MA0888.1	EVX2	MA0888.1	2.61e-158	2.25e-155
186	MA1577.1	TLX2	MA1577.1	1.36e-156	1.18e-153
187	MA0901.2	HOXB13	MA0901.2	2.01e-156	1.73e-153
188	MA0468.1	DUX4	MA0468.1	4.34e-156	3.74e-153
189	MA0033.2	FOXL1	MA0033.2	9.83e-156	8.48e-153
190	MA0035.4	GATA1	MA0035.4	6.49e-155	5.6e-152
191	MA0906.1	HOXC12	MA0906.1	6.55e-155	5.65e-152
192	MA0755.1	CUX2	MA0755.1	9.53e-155	8.21e-152
193	MA1519.1	LHX5	MA1519.1	1.4e-154	1.21e-151
194	MA0480.2	Foxo1	MA0480.2	1.61e-153	1.39e-150
195	MA0848.1	FOXO4	MA0848.1	1.75e-153	1.51e-150
196	MA1120.1	SOX13	MA1120.1	2.17e-152	1.87e-149
197	MA0125.1	Nobox	MA0125.1	2.27e-151	1.96e-148
198	MA0479.1	FOXH1	MA0479.1	3.89e-151	3.36e-148
199	MA0887.1	EVX1	MA0887.1	9.26e-151	7.98e-148
200	MA0621.1	mix-a	MA0621.1	1.71e-150	1.47e-147
201	MA0895.1	HMBOX1	MA0895.1	3.21e-150	2.76e-147
202	MA0852.2	FOXK1	MA0852.2	1.42e-148	1.22e-145
203	MA0716.1	PRRX1	MA0716.1	2.5e-148	2.15e-145
204	MA0618.1	LBX1	MA0618.1	4.14e-148	3.57e-145
205	MA0151.1	Arid3a	MA0151.1	5.41e-148	4.66e-145
206	MA0700.2	LHX2	MA0700.2	1.12e-147	9.63e-145
207	MA1481.1	DRGX	MA1481.1	4.03e-147	3.47e-144
208	MA0514.2	Sox3	MA0514.2	4.34e-147	3.74e-144
209	MA0642.2	EN2	MA0642.2	1.66e-146	1.43e-143
210	MA0465.2	CDX2	MA0465.2	4.25e-146	3.66e-143
211	MA0593.1	FOXP2	MA0593.1	4.9e-146	4.22e-143
212	MA0720.1	Shox2	MA0720.1	2.43e-144	2.09e-141
213	MA0890.1	GBX2	MA0890.1	4.71e-144	4.06e-141
214	MA0854.1	Alx1	MA0854.1	1.64e-142	1.41e-139
215	MA1563.2	SOX18	MA1563.2	4.6e-142	3.96e-139
216	MA1476.2	Dlx5	MA1476.2	5.44e-141	4.69e-138
217	MA0838.1	CEBPG	MA0838.1	5.92e-141	5.1e-138
218	MA0885.2	Dlx2	MA0885.2	2.61e-140	2.25e-137
219	MA0867.2	SOX4	MA0867.2	9.09e-140	7.83e-137
220	MA0712.2	OTX2	MA0712.2	1.26e-139	1.09e-136
221	MA1580.1	ZBTB32	MA1580.1	2.85e-139	2.46e-136
222	MA1126.1	FOS::JUN	MA1126.1	4.13e-139	3.56e-136
223	MA0515.1	Sox6	MA0515.1	9.81e-139	8.45e-136
224	MA0853.1	Alx4	MA0853.1	6.16e-138	5.31e-135
225	MA0879.2	DLX1	MA0879.2	3.77e-137	3.25e-134
226	MA1489.1	FOXN3	MA1489.1	4.99e-137	4.3e-134
227	MA0068.2	PAX4	MA0068.2	7.61e-137	6.56e-134
228	MA0718.1	RAX	MA0718.1	1.27e-136	1.1e-133
229	MA0042.2	FOXI1	MA0042.2	1.61e-136	1.39e-133
230	MA0648.1	GSC	MA0648.1	2.18e-136	1.88e-133
231	MA0678.1	OLIG2	MA0678.1	2.92e-136	2.52e-133
232	MA1125.1	ZNF384	MA1125.1	3.36e-136	2.9e-133
233	MA0850.1	FOXP3	MA0850.1	5.87e-136	5.06e-133
234	MA0705.1	Lhx8	MA0705.1	7.93e-136	6.83e-133
235	MA1520.1	MAF	MA1520.1	8.18e-136	7.06e-133
237	MA1707.1	DMRTA1	MA1707.1	5.83e-134	5.02e-131
238	MA0721.1	UNCX	MA0721.1	2.4e-133	2.07e-130
239	MA0620.3	MITF	MA0620.3	5.24e-133	4.52e-130
240	MA1518.2	Lhx1	MA1518.2	6.07e-133	5.23e-130
241	MA0682.2	PITX1	MA0682.2	9.5e-133	8.19e-130
242	MA0754.2	CUX1	MA0754.2	1.15e-132	9.9e-130
243	MA0876.1	BSX	MA0876.1	1.18e-132	1.02e-129
244	MA0108.2	TBP	MA0108.2	1.86e-132	1.6e-129
245	MA1657.1	ZNF652	MA1657.1	3.16e-132	2.72e-129
246	MA0122.3	Nkx3-2	MA0122.3	6.5e-132	5.6e-129
247	MA0106.3	TP53	MA0106.3	1.09e-131	9.37e-129
248	MA1503.1	HOXB9	MA1503.1	4.78e-130	4.12e-127
249	MA0837.2	CEBPE	MA0837.2	2.36e-129	2.04e-126
251	MA1608.1	Isl1	MA1608.1	6.96e-129	5.99e-126
252	MA0497.1	MEF2C	MA0497.1	2.62e-128	2.26e-125
253	MA1478.1	DMRTA2	MA1478.1	3.77e-128	3.25e-125
254	MA0078.2	Sox17	MA0078.2	3.77e-127	3.25e-124
255	MA0666.2	MSX1	MA0666.2	1.46e-126	1.26e-123
256	MA1501.1	HOXB7	MA1501.1	2.26e-126	1.95e-123
257	MA0662.1	MIXL1	MA0662.1	3.07e-126	2.65e-123
258	MA1498.2	HOXA7	MA1498.2	4.36e-126	3.76e-123
259	MA0709.1	Msx3	MA0709.1	5.27e-126	4.54e-123
260	MA0891.1	GSC2	MA0891.1	2.17e-125	1.87e-122
261	MA0702.2	LMX1A	MA0702.2	3.91e-125	3.37e-122
262	MA0894.1	HESX1	MA0894.1	6.71e-125	5.79e-122
263	MA0442.2	SOX10	MA0442.2	9.89e-125	8.52e-122
264	MA1497.1	HOXA6	MA1497.1	1.61e-124	1.39e-121
265	MA0717.1	RAX2	MA0717.1	4.53e-124	3.9e-121
266	MA0140.2	GATA1::TAL1	MA0140.2	1.4e-122	1.2e-119
267	MA0817.1	BHLHE23	MA0817.1	4.94e-122	4.25e-119
268	MA0907.1	HOXC13	MA0907.1	2.03e-120	1.75e-117
269	MA0610.1	DMRT3	MA0610.1	1.03e-119	8.89e-117
270	MA1970.1	TRPS1	MA1970.1	1.83e-119	1.57e-116
272	MA1718.1	ZNF8	MA1718.1	6.64e-119	5.72e-116
273	MA0018.4	CREB1	MA0018.4	1.89e-118	1.63e-115
275	MA0634.1	ALX3	MA0634.1	6.89e-118	5.94e-115
276	MA0461.2	Atoh1	MA0461.2	2.04e-117	1.76e-114
277	MA0769.2	TCF7	MA0769.2	3.78e-117	3.25e-114
278	MA0873.1	HOXD12	MA0873.1	1.37e-115	1.18e-112
279	MA0029.1	Mecom	MA0029.1	3.85e-115	3.32e-112
280	MA0699.1	LBX2	MA0699.1	3.46e-114	2.99e-111
281	MA0889.1	GBX1	MA0889.1	3.77e-114	3.25e-111
282	MA1729.1	ZNF680	MA1729.1	5.88e-114	5.07e-111
283	MA0861.1	TP73	MA0861.1	1.51e-113	1.3e-110
284	MA1104.2	GATA6	MA1104.2	2.7e-113	2.33e-110
285	MA1521.1	MAFA	MA1521.1	3.03e-113	2.61e-110
286	MA0893.2	GSX2	MA0893.2	3.57e-113	3.08e-110
287	MA0708.2	MSX2	MA0708.2	1.94e-112	1.67e-109
288	MA1150.1	RORB	MA1150.1	1.48e-111	1.28e-108
289	MA0898.1	Hmx3	MA0898.1	5.62e-111	4.84e-108
290	MA1960.1	MGA::EVX1	MA1960.1	2.17e-110	1.87e-107
291	MA0069.1	PAX6	MA0069.1	3.46e-110	2.98e-107
292	MA0897.1	Hmx2	MA0897.1	1.38e-109	1.19e-106
293	MA0827.1	OLIG3	MA0827.1	6.81e-109	5.87e-106
294	MA0093.3	USF1	MA0093.3	8.31e-108	7.17e-105
295	MA1119.1	SIX2	MA1119.1	1.1e-107	9.51e-105
296	MA0883.1	Dmbx1	MA0883.1	6.57e-107	5.66e-104
297	MA0631.1	Six3	MA0631.1	1.29e-106	1.11e-103
298	MA0492.1	JUND	MA0492.1	1.67e-106	1.44e-103
299	MA0483.1	Gfi1B	MA0483.1	5.39e-106	4.65e-103
300	MA0626.1	Npas2	MA0626.1	2.49e-105	2.14e-102
301	MA0037.4	Gata3	MA0037.4	4.86e-105	4.19e-102
302	MA1139.1	FOSL2::JUNB	MA1139.1	5.89e-105	5.08e-102
303	MA0768.2	Lef1	MA0768.2	7.64e-105	6.59e-102
304	MA1473.1	CDX4	MA1473.1	2.94e-104	2.54e-101
305	MA0594.2	HOXA9	MA0594.2	4.83e-104	4.16e-101
306	MA0913.2	HOXD9	MA0913.2	6.16e-104	5.31e-101
307	MA1709.1	ZIM3	MA1709.1	1.43e-103	1.23e-100
308	MA0520.1	Stat6	MA0520.1	2.24e-103	1.93e-100
309	MA1623.1	Stat2	MA1623.1	2.54e-103	2.19e-100
310	MA1506.1	HOXD10	MA1506.1	5.48e-103	4.72e-100
311	MA1995.1	Npas4	MA1995.1	3.02e-102	2.61e-99
312	MA0036.3	GATA2	MA0036.3	1.16e-101	1e-98
313	MA0087.2	Sox5	MA0087.2	2.72e-101	2.34e-98
314	MA1562.1	SOX14	MA1562.1	6.78e-101	5.84e-98
315	MA0050.3	Irf1	MA0050.3	7.9e-101	6.81e-98
316	MA0826.1	OLIG1	MA0826.1	1.83e-99	1.58e-96
317	MA1588.1	ZNF136	MA1588.1	3.5e-99	3.01e-96
318	MA1632.1	ATF2	MA1632.1	7.28e-99	6.28e-96
319	MA1131.1	FOSL2::JUN	MA1131.1	3.86e-98	3.33e-95
320	MA1129.1	FOSL1::JUN	MA1129.1	2.3e-97	1.99e-94
321	MA0488.1	JUN	MA0488.1	4.08e-97	3.51e-94
322	MA0482.2	GATA4	MA0482.2	8.08e-97	6.97e-94
323	MA0596.1	SREBF2	MA0596.1	2.62e-94	2.26e-91
324	MA0773.1	MEF2D	MA0773.1	4.66e-94	4.02e-91
325	MA0606.2	Nfat5	MA0606.2	6.56e-94	5.66e-91
326	MA0782.2	PKNOX1	MA0782.2	1.05e-93	9.03e-91
327	MA0914.1	ISL2	MA0914.1	1.84e-93	1.59e-90
328	MA0635.1	BARHL2	MA0635.1	2.78e-93	2.4e-90
329	MA0660.1	MEF2B	MA0660.1	3.61e-93	3.11e-90
330	MA0869.2	Sox11	MA0869.2	7.39e-93	6.37e-90
331	MA0896.1	Hmx1	MA0896.1	2.27e-92	1.96e-89
332	MA1989.1	Bcl11B	MA1989.1	6.93e-91	5.98e-88
333	MA1561.1	SOX12	MA1561.1	9.46e-91	8.16e-88
334	MA0063.2	NKX2-5	MA0063.2	1.42e-90	1.22e-87
335	MA0689.1	TBX20	MA0689.1	1.98e-90	1.7e-87
336	MA0095.3	Yy1	MA0095.3	3.1e-90	2.67e-87
337	MA1118.1	SIX1	MA1118.1	6.8e-90	5.86e-87
338	MA1720.1	ZNF85	MA1720.1	2.93e-89	2.53e-86
339	MA1145.1	FOSL2::JUND	MA1145.1	9.86e-89	8.49e-86
340	MA1975.1	ZNF214	MA1975.1	3.34e-87	2.88e-84
341	MA0467.2	Crx	MA0467.2	2.2e-86	1.9e-83
342	MA1523.1	MSANTD3	MA1523.1	1.33e-85	1.14e-82
343	MA0693.3	Vdr	MA0693.3	7.88e-85	6.79e-82
344	MA0523.1	TCF7L2	MA0523.1	1.2e-84	1.03e-81
345	MA0714.1	PITX3	MA0714.1	2.59e-84	2.23e-81
346	MA0719.1	RHOXF1	MA0719.1	4.88e-84	4.21e-81
347	MA1618.1	Ptf1a	MA1618.1	6.65e-84	5.73e-81
348	MA0629.1	Rhox11	MA0629.1	7.85e-82	6.76e-79
349	MA1133.1	JUN::JUNB	MA1133.1	5.07e-81	4.37e-78
350	MA0829.2	SREBF1	MA0829.2	1.61e-80	1.39e-77
351	MA0804.1	TBX19	MA0804.1	2.59e-79	2.23e-76
352	MA0619.1	LIN54	MA0619.1	4.88e-79	4.21e-76
353	MA1991.1	Hnf1A	MA1991.1	4.89e-79	4.21e-76
354	MA0651.2	HOXC11	MA0651.2	7.35e-79	6.33e-76
355	MA1547.2	PITX2	MA1547.2	9.28e-79	8e-76
356	MA0623.2	NEUROG1	MA0623.2	1.67e-78	1.44e-75
357	MA1108.2	MXI1	MA1108.2	5.06e-78	4.36e-75
358	MA0687.1	SPIC	MA0687.1	1.79e-77	1.54e-74
359	MA0466.3	CEBPB	MA0466.3	2.38e-77	2.05e-74
360	MA1151.1	RORC	MA1151.1	7.44e-77	6.42e-74
83	MA1125.1 (ZNF384)	MEME-1	AAAWAAAAAAAAAAA	4.1e-229	6e-73
361	MA1570.1	TFAP4	MA1570.1	7.59e-76	6.54e-73
362	MA0525.2	TP63	MA0525.2	4.51e-75	3.89e-72
363	MA0038.2	GFI1	MA0038.2	9.71e-75	8.37e-72
5	MA0477.2 (FOSL1)	MEME-2	TGAGTCAT	4.52e-305	2.4e-70
364	MA0684.2	RUNX3	MA0684.2	2.95e-73	2.54e-70
365	MA0772.1	IRF7	MA0772.1	5.13e-73	4.42e-70
366	MA1105.2	GRHL2	MA1105.2	7.55e-73	6.51e-70
367	MA0072.1	RORA	MA0072.1	4.81e-72	4.14e-69
368	MA1114.1	PBX3	MA1114.1	4.88e-72	4.21e-69
369	MA1148.1	PPARA::RXRA	MA1148.1	3.97e-71	3.42e-68
370	MA0607.2	BHLHA15	MA0607.2	9.21e-71	7.95e-68
371	MA1123.2	TWIST1	MA1123.2	1.25e-70	1.08e-67
372	MA1592.1	ZNF274	MA1592.1	1.41e-68	1.22e-65
373	MA1956.1	FOXO1::FLI1	MA1956.1	2.44e-68	2.11e-65
374	MA1585.1	ZKSCAN1	MA1585.1	4.73e-68	4.08e-65
375	MA0595.1	SREBF1	MA0595.1	1.45e-66	1.25e-63
376	MA0743.2	SCRT1	MA0743.2	2.95e-66	2.54e-63
377	MA1534.1	NR1I3	MA1534.1	6.75e-66	5.82e-63
378	MA0647.1	GRHL1	MA0647.1	1.35e-64	1.17e-61
379	MA0698.1	ZBTB18	MA0698.1	6.19e-64	5.33e-61
380	MA1953.1	FOXO1::ELF1	MA1953.1	2.2e-63	1.9e-60
381	MA0711.1	OTX1	MA0711.1	2.22e-63	1.91e-60
382	MA1127.1	FOSB::JUN	MA1127.1	6.8e-63	5.86e-60
383	MA2001.1	Six4	MA2001.1	1.18e-62	1.02e-59
384	MA0703.2	LMX1B	MA0703.2	1.25e-62	1.08e-59
385	MA1136.1	FOSB::JUNB	MA1136.1	2.43e-62	2.1e-59
386	MA0756.2	ONECUT2	MA0756.2	2.59e-62	2.23e-59
387	MA1596.1	ZNF460	MA1596.1	1.51e-61	1.3e-58
388	MA1994.1	Nkx2-1	MA1994.1	5.38e-61	4.64e-58
389	MA1645.1	NKX2-2	MA1645.1	7.1e-61	6.12e-58
390	MA0840.1	Creb5	MA0840.1	4.27e-59	3.69e-56
391	MA0669.1	NEUROG2	MA0669.1	2.87e-57	2.48e-54
392	MA1594.1	ZNF382	MA1594.1	1.05e-56	9.03e-54
393	MA1980.1	ZNF418	MA1980.1	1.29e-56	1.12e-53
23	MA1634.1 (BATF)	STREME-2	2-NTGASTCAN	3.82e-305	6.02e-53
394	MA1644.1	NFYC	MA1644.1	1.43e-55	1.23e-52
395	MA0688.1	TBX2	MA0688.1	1.82e-55	1.57e-52
396	MA1546.1	PAX3	MA1546.1	5.2e-55	4.48e-52
397	MA0766.2	GATA5	MA0766.2	5.74e-55	4.95e-52
398	MA0809.2	TEAD4	MA0809.2	1.06e-54	9.16e-52
399	MA1112.2	NR4A1	MA1112.2	1.1e-53	9.51e-51
400	MA0114.4	HNF4A	MA0114.4	4.15e-53	3.58e-50
401	MA0744.2	SCRT2	MA0744.2	1.13e-52	9.74e-50
402	MA0164.1	Nr2e3	MA0164.1	3.7e-52	3.2e-49
403	MA0818.2	BHLHE22	MA0818.2	4.06e-52	3.5e-49
404	MA1524.2	Msgn1	MA1524.2	5.5e-52	4.74e-49
405	MA1998.1	Prdm14	MA1998.1	1.11e-50	9.54e-48
406	MA0019.1	Ddit3::Cebpa	MA0019.1	8.96e-50	7.72e-47
407	MA0498.2	MEIS1	MA0498.2	1.12e-49	9.65e-47
408	MA0484.2	HNF4G	MA0484.2	1.54e-49	1.33e-46
409	MA0494.1	Nr1h3::Rxra	MA0494.1	1.9e-49	1.63e-46
410	MA1717.1	ZNF784	MA1717.1	2.19e-49	1.88e-46
411	MA0124.2	Nkx3-1	MA0124.2	5.22e-49	4.5e-46
412	MA0508.3	PRDM1	MA0508.3	1.13e-48	9.77e-46
413	MA0877.3	BARHL1	MA0877.3	1.99e-48	1.71e-45
414	MA0090.3	TEAD1	MA0090.3	9.86e-48	8.5e-45
415	MA0517.1	STAT1::STAT2	MA0517.1	9.99e-47	8.61e-44
416	MA0862.1	GMEB2	MA0862.1	1.09e-46	9.41e-44
417	MA0802.1	TBR1	MA0802.1	3.14e-46	2.71e-43
418	MA1111.1	NR2F2	MA1111.1	2.23e-45	1.92e-42
419	MA1625.1	Stat5b	MA1625.1	5.94e-45	5.12e-42
420	MA0800.1	EOMES	MA0800.1	6.5e-45	5.61e-42
421	MA1714.1	ZNF675	MA1714.1	1.01e-44	8.75e-42
422	MA0144.2	STAT3	MA0144.2	1.31e-43	1.13e-40
423	MA1951.1	FOS	MA1951.1	2.86e-43	2.47e-40
424	MA0485.2	HOXC9	MA0485.2	3.9e-43	3.36e-40
426	MA0152.2	Nfatc2	MA0152.2	5.44e-43	4.69e-40
427	MA1593.1	ZNF317	MA1593.1	7.28e-42	6.28e-39
428	MA1624.1	Stat5a	MA1624.1	2.05e-41	1.77e-38
429	MA1977.1	ZNF324	MA1977.1	4.63e-41	3.99e-38
430	MA0258.2	ESR2	MA0258.2	4.96e-41	4.28e-38
431	MA1468.1	ATOH7	MA1468.1	8.43e-41	7.26e-38
48	3-ATRTAYAT	STREME-3	3-ATRTAYAT	6.9e-303	7.6e-38
432	MA1937.1	ERF::HOXB13	MA1937.1	4.15e-40	3.58e-37
433	MA0002.2	Runx1	MA0002.2	5.25e-40	4.52e-37
434	MA0609.2	CREM	MA0609.2	8.86e-39	7.63e-36
435	MA1952.1	FOXJ2::ELF1	MA1952.1	1.53e-38	1.32e-35
436	MA1121.1	TEAD2	MA1121.1	9.37e-38	8.08e-35
437	MA0692.1	TFEB	MA0692.1	1.5e-37	1.29e-34
438	MA1555.1	RXRB	MA1555.1	2.81e-37	2.42e-34
439	MA0060.3	NFYA	MA0060.3	4.35e-37	3.75e-34
440	MA0463.2	BCL6	MA0463.2	4.94e-37	4.26e-34
441	MA1553.1	RARG	MA1553.1	1.29e-36	1.11e-33
442	MA1572.1	TGIF2LY	MA1572.1	1.59e-36	1.37e-33
443	MA1638.1	HAND2	MA1638.1	1.95e-36	1.68e-33
444	MA1467.2	Atoh1	MA1467.2	2.12e-36	1.82e-33
445	MA1541.1	NR6A1	MA1541.1	7.45e-36	6.42e-33
446	MA1983.1	ZNF582	MA1983.1	2.52e-35	2.17e-32
447	MA0795.1	SMAD3	MA0795.1	3.43e-35	2.96e-32
57	4-TGTAATC	STREME-4	4-TGTAATC	5.17e-269	3.85e-32
448	MA1146.1	NR1H4::RXRA	MA1146.1	1.81e-34	1.56e-31
449	MA1647.2	Prdm4	MA1647.2	6.17e-34	5.31e-31
450	MA1557.1	SMAD5	MA1557.1	9.74e-34	8.4e-31
451	MA1950.1	FLI1::FOXI1	MA1950.1	1.25e-33	1.08e-30
452	MA1587.1	ZNF135	MA1587.1	2.18e-33	1.88e-30
453	MA0141.3	ESRRB	MA0141.3	2.47e-33	2.13e-30
454	MA1984.1	ZNF667	MA1984.1	5.23e-33	4.51e-30
41	MA0817.1 (BHLHE23)	STREME-5	5-AAWCATAT	4.04e-305	4.88e-30
455	MA1651.1	ZFP42	MA1651.1	6.36e-32	5.48e-29
456	MA0160.2	NR4A2	MA0160.2	7.62e-32	6.57e-29
457	MA1620.1	Ptf1A	MA1620.1	1.76e-31	1.52e-28
458	MA0807.1	TBX5	MA0807.1	2.27e-31	1.95e-28
459	MA0071.1	RORA	MA0071.1	2.43e-31	2.1e-28
36	MA1632.1 (ATF2)	STREME-6	6-AAGTSATCH	4.27e-305	2.49e-28
460	MA0797.1	TGIF2	MA0797.1	3.01e-31	2.6e-28
461	MA1642.1	NEUROG2	MA1642.1	2.72e-30	2.34e-27
462	MA0866.1	SOX21	MA0866.1	2.96e-30	2.55e-27
463	MA1147.1	NR4A2::RXRA	MA1147.1	3.75e-30	3.23e-27
464	MA0056.2	MZF1	MA0056.2	3.83e-30	3.3e-27
465	MA1552.1	RARB	MA1552.1	6.83e-30	5.89e-27
466	MA0624.2	Nfatc1	MA0624.2	8.9e-30	7.67e-27
467	MA1571.1	TGIF2LX	MA1571.1	2.1e-29	1.81e-26
468	MA0519.1	Stat5a::Stat5b	MA0519.1	2.91e-29	2.51e-26
469	MA0673.1	NKX2-8	MA0673.1	1.24e-28	1.07e-25
470	MA1955.1	FOXO1::ELK3	MA1955.1	2.7e-28	2.33e-25
471	MA0592.3	ESRRA	MA0592.3	3.74e-28	3.22e-25
472	MA1968.1	TFCP2	MA1968.1	5.6e-28	4.83e-25
473	MA1567.2	Tbx6	MA1567.2	1.2e-27	1.04e-24
474	MA0006.1	Ahr::Arnt	MA0006.1	1.59e-27	1.37e-24
475	MA0825.1	MNT	MA0825.1	1.87e-27	1.61e-24
476	MA0083.3	SRF	MA0083.3	1.92e-27	1.65e-24
477	MA1949.1	FLI1::DRGX	MA1949.1	2.23e-27	1.92e-24
58	7-AVTABT	STREME-7	7-AVTABT	1.59e-265	2.31e-24
478	MA1536.1	NR2C2	MA1536.1	2.74e-27	2.36e-24
479	MA1475.1	CREB3L4	MA1475.1	4.11e-27	3.55e-24
480	MA1621.1	Rbpjl	MA1621.1	5.84e-27	5.03e-24
481	MA0771.1	HSF4	MA0771.1	1.29e-26	1.11e-23
482	MA0111.1	Spz1	MA0111.1	1.58e-26	1.36e-23
483	MA0603.1	Arntl	MA0603.1	2e-26	1.72e-23
484	MA1420.1	IRF5	MA1420.1	2.17e-26	1.87e-23
485	MA0080.6	Spi1	MA0080.6	3.03e-26	2.61e-23
486	MA1509.1	IRF6	MA1509.1	9.52e-26	8.2e-23
38	8-WCATGW	STREME-8	8-WCATGW	1.55e-305	3.98e-22
153	9-AAYWRTT	STREME-9	9-AAYWRTT	6.27e-173	5.64e-22
487	MA0066.1	PPARG	MA0066.1	1.5e-24	1.29e-21
488	MA0518.1	Stat4	MA0518.1	3e-24	2.59e-21
489	MA1943.1	ETV2::HOXB13	MA1943.1	9.31e-24	8.02e-21
490	MA0667.1	MYF6	MA0667.1	3.18e-23	2.74e-20
491	MA0831.3	TFE3	MA0831.3	3.69e-23	3.18e-20
492	MA1573.2	Thap11	MA1573.2	5.22e-23	4.5e-20
493	MA0819.2	CLOCK	MA0819.2	9.42e-23	8.12e-20
494	MA0805.1	TBX1	MA0805.1	9.44e-23	8.14e-20
495	MA0009.2	TBXT	MA0009.2	1.2e-21	1.04e-18
496	MA1616.1	Prdm15	MA1616.1	1.24e-21	1.07e-18
497	MA1568.1	TCF21	MA1568.1	1.32e-21	1.14e-18
498	MA1421.1	TCF7L1	MA1421.1	1.4e-21	1.2e-18
499	MA0672.1	NKX2-3	MA0672.1	1.4e-21	1.21e-18
51	10-TRTAYA	STREME-10	10-TRTAYA	5.08e-291	2.13e-18
500	MA1110.2	Nr1H4	MA1110.2	3.72e-21	3.21e-18
501	MA1558.1	SNAI1	MA1558.1	8.34e-21	7.19e-18
502	MA0844.1	XBP1	MA0844.1	1e-20	8.66e-18
503	MA0502.2	NFYB	MA0502.2	1.07e-20	9.2e-18
236	11-CTCCCAARKWGCTGG	STREME-11	11-CTCCCAARKWGCTGG	8.73e-136	1.05e-17
504	MA1954.1	FOXO1::ELK1	MA1954.1	1.69e-20	1.46e-17
505	MA1574.1	THRB	MA1574.1	3.63e-20	3.13e-17
274	MA1973.1 (ZKSCAN3)	MEME-3	CCAGCCTGGGYRACA	3.92e-118	4.3e-17
506	MA1540.2	NR5A1	MA1540.2	5.05e-20	4.36e-17
507	MA0604.1	Atf1	MA0604.1	5.86e-20	5.05e-17
508	MA0656.1	JDP2	MA0656.1	6.41e-20	5.52e-17
509	MA1947.1	ETV5::FOXO1	MA1947.1	1.21e-19	1.04e-16
510	MA0100.3	MYB	MA0100.3	1.52e-19	1.31e-16
511	MA0091.1	TAL1::TCF3	MA0091.1	1.61e-19	1.39e-16
512	MA0728.1	Nr2F6	MA0728.1	2.32e-19	2e-16
513	MA1109.1	NEUROD1	MA1109.1	2.89e-19	2.49e-16
514	MA0643.1	Esrrg	MA0643.1	3.78e-19	3.26e-16
515	MA0806.1	TBX4	MA0806.1	5.72e-19	4.93e-16
516	MA0130.1	ZNF354C	MA0130.1	6.95e-19	5.99e-16
517	MA1971.1	ZBED2	MA1971.1	9.69e-19	8.36e-16
518	MA1958.1	HOXD12::ELK1	MA1958.1	1.27e-18	1.1e-15
519	MA1942.1	ETV2::FOXI1	MA1942.1	1.29e-18	1.11e-15
520	MA1116.1	RBPJ	MA1116.1	1.37e-18	1.18e-15
521	MA0137.3	STAT1	MA0137.3	1.83e-18	1.58e-15
522	MA0014.3	PAX5	MA0014.3	2.03e-18	1.75e-15
523	MA0803.1	TBX15	MA0803.1	2.1e-18	1.81e-15
524	MA0668.2	Neurod2	MA0668.2	2.48e-18	2.14e-15
525	MA0808.1	TEAD3	MA0808.1	2.93e-18	2.52e-15
526	MA0103.3	ZEB1	MA0103.3	3.99e-18	3.44e-15
527	MA0767.1	GCM2	MA0767.1	5.51e-18	4.75e-15
528	MA1474.1	CREB3L4	MA1474.1	5.63e-18	4.85e-15
529	MA0695.1	ZBTB7C	MA0695.1	7.21e-18	6.21e-15
530	MA0486.2	HSF1	MA0486.2	7.64e-18	6.58e-15
531	MA1946.1	ETV5::FOXI1	MA1946.1	3.5e-17	3.02e-14
532	MA0747.1	SP8	MA0747.1	5.05e-17	4.36e-14
533	MA0081.2	SPIB	MA0081.2	5.26e-17	4.54e-14
534	MA0820.1	FIGLA	MA0820.1	9.11e-17	7.85e-14
425	MA1107.2 (KLF9)	MEME-4	GTGTGTGTGTGTGTG	4.84e-43	8.3e-14
535	MA0598.3	EHF	MA0598.3	1.42e-16	1.22e-13
536	MA0691.1	TFAP4	MA0691.1	2.37e-16	2.04e-13
537	MA0690.2	TBX21	MA0690.2	2.44e-16	2.1e-13
538	MA0528.2	ZNF263	MA0528.2	2.46e-16	2.12e-13
539	MA1996.1	Nr1H2	MA1996.1	4.83e-16	4.17e-13
540	MA1940.1	ETV2::DRGX	MA1940.1	5.99e-16	5.16e-13
541	MA0065.2	Pparg::Rxra	MA0065.2	6.59e-16	5.68e-13
542	MA1602.1	ZSCAN29	MA1602.1	6.8e-16	5.86e-13
35	12-TAAGAMA	STREME-12	12-TAAGAMA	9.35e-305	5.93e-13
543	MA0770.1	HSF2	MA0770.1	8.05e-16	6.94e-13
544	MA1964.1	SMAD2	MA1964.1	8.79e-16	7.57e-13
81	13-ATASTAT	STREME-13	13-ATASTAT	2.47e-230	7.96e-13
545	MA1652.1	ZKSCAN5	MA1652.1	1.11e-15	9.53e-13
179	MA1623.1 (Stat2)	STREME-14	14-AAAAAGAAA	1.67e-159	1.09e-12
546	MA1517.1	KLF6	MA1517.1	3.14e-15	2.71e-12
547	MA0505.2	Nr5A2	MA0505.2	3.16e-15	2.73e-12
548	MA0092.1	Hand1::Tcf3	MA0092.1	3.48e-15	3e-12
549	MA0752.1	ZNF410	MA0752.1	4.59e-15	3.95e-12
550	MA1149.1	RARA::RXRG	MA1149.1	6.58e-15	5.67e-12
551	MA0615.1	Gmeb1	MA0615.1	6.87e-15	5.92e-12
552	MA0058.3	MAX	MA0058.3	6.92e-15	5.96e-12
553	MA0059.1	MAX::MYC	MA0059.1	8.92e-15	7.69e-12
554	MA0776.1	MYBL1	MA0776.1	1.79e-14	1.54e-11
555	MA1724.1	Rfx6	MA1724.1	3.2e-14	2.76e-11
556	MA1944.1	ETV5::DRGX	MA1944.1	4.71e-14	4.06e-11
557	MA1532.2	NR1D2	MA1532.2	5.98e-14	5.16e-11
558	MA0677.1	Nr2f6	MA0677.1	1.56e-13	1.34e-10
559	MA1936.1	ERF::FOXO1	MA1936.1	2.72e-13	2.34e-10
560	MA0801.1	MGA	MA0801.1	2.76e-13	2.38e-10
561	MA0834.1	ATF7	MA0834.1	4.74e-13	4.08e-10
562	MA2003.1	NKX2-4	MA2003.1	5.04e-13	4.34e-10
563	MA1117.1	RELB	MA1117.1	5.12e-13	4.41e-10
564	MA1619.1	Ptf1A	MA1619.1	5.15e-13	4.44e-10
565	MA1508.1	IKZF1	MA1508.1	5.94e-13	5.12e-10
566	MA1155.1	ZSCAN4	MA1155.1	8.63e-13	7.44e-10
567	MA0051.1	IRF2	MA0051.1	9.45e-13	8.15e-10
568	MA1948.1	ETV5::HOXA2	MA1948.1	9.7e-13	8.36e-10
569	MA0775.1	MEIS3	MA0775.1	1.07e-12	9.27e-10
154	MA0041.2 (FOXD3)	MEME-5	AAAWGMAAAWWAAAA	7.97e-173	1.4e-09
570	MA1525.2	NFATC4	MA1525.2	2.69e-12	2.32e-09
571	MA2002.1	Zfp335	MA2002.1	2.96e-12	2.55e-09
572	MA1533.1	NR1I2	MA1533.1	3.1e-12	2.68e-09
573	MA1107.2	KLF9	MA1107.2	3.58e-12	3.09e-09
574	MA0039.4	KLF4	MA0039.4	4.49e-12	3.87e-09
575	MA0761.2	ETV1	MA0761.2	5.07e-12	4.37e-09
576	MA1649.1	ZBTB12	MA1649.1	5.41e-12	4.66e-09
577	MA0664.1	MLXIPL	MA0664.1	1.3e-11	1.12e-08
578	MA0003.4	TFAP2A	MA0003.4	2.24e-11	1.93e-08
579	MA0733.1	EGR4	MA0733.1	3.21e-11	2.77e-08
580	MA1579.1	ZBTB26	MA1579.1	3.22e-11	2.77e-08
581	MA0161.2	NFIC	MA0161.2	3.54e-11	3.05e-08
582	MA1601.2	ZNF75D	MA1601.2	4.1e-11	3.53e-08
583	MA0653.1	IRF9	MA0653.1	4.73e-11	4.08e-08
584	MA1581.1	ZBTB6	MA1581.1	4.98e-11	4.3e-08
585	MA1957.1	HOXB2::ELK1	MA1957.1	7.32e-11	6.31e-08
586	MA0816.1	Ascl2	MA0816.1	9.74e-11	8.39e-08
587	MA1999.1	Prdm5	MA1999.1	1.24e-10	1.07e-07
588	MA0748.2	YY2	MA0748.2	1.37e-10	1.18e-07
589	MA1100.2	ASCL1	MA1100.2	1.7e-10	1.47e-07
590	MA1641.1	MYF5	MA1641.1	1.75e-10	1.51e-07
591	MA0794.1	PROX1	MA0794.1	2.02e-10	1.74e-07
592	MA0511.2	RUNX2	MA0511.2	3.07e-10	2.64e-07
593	MA0101.1	REL	MA0101.1	4.79e-10	4.13e-07
594	MA1550.1	PPARD	MA1550.1	4.93e-10	4.25e-07
595	MA0521.2	Tcf12	MA0521.2	6.14e-10	5.29e-07
271	MA1596.1 (ZNF460)	MEME-6	TTGGGAGGCYGAGGY	6.14e-119	6.3e-07
596	MA1472.2	Bhlha15	MA1472.2	7.34e-10	6.33e-07
597	MA1708.1	ETV7	MA1708.1	1.48e-09	1.28e-06
598	MA1589.1	ZNF140	MA1589.1	1.96e-09	1.69e-06
599	MA1153.1	Smad4	MA1153.1	5.78e-09	4.98e-06
600	MA0147.3	MYC	MA0147.3	5.85e-09	5.04e-06
601	MA1493.1	HES6	MA1493.1	6e-09	5.17e-06
602	MA1566.2	TBX3	MA1566.2	6.99e-09	6.02e-06
603	MA0510.2	RFX5	MA0510.2	6.99e-09	6.02e-06
604	MA0646.1	GCM1	MA0646.1	7.6e-09	6.55e-06
605	MA0473.3	ELF1	MA0473.3	7.69e-09	6.63e-06
250	MA0682.2 (PITX1)	MEME-7	CCTGTAATCCCAGCA	4.02e-129	7.9e-06
606	MA0474.3	Erg	MA0474.3	2.4e-08	2.06e-05
607	MA0870.1	Sox1	MA0870.1	2.95e-08	2.54e-05
608	MA0741.1	KLF16	MA0741.1	3.04e-08	2.62e-05
609	MA0828.2	SREBF2	MA0828.2	3.69e-08	3.18e-05
610	MA0871.2	TFEC	MA0871.2	3.77e-08	3.25e-05
611	MA0859.1	Rarg	MA0859.1	5e-08	4.31e-05
612	MA1560.1	SOHLH2	MA1560.1	9.44e-08	8.13e-05
613	MA1723.1	PRDM9	MA1723.1	1.33e-07	0.000115
614	MA0734.3	Gli2	MA0734.3	1.71e-07	0.000147
615	MA0640.2	ELF3	MA0640.2	1.73e-07	0.00015
616	MA1731.1	ZNF768	MA1731.1	2.09e-07	0.00018
617	MA0857.1	Rarb	MA0857.1	2.22e-07	0.000191
618	MA1627.1	Wt1	MA1627.1	3.06e-07	0.000264
619	MA1631.1	ASCL1	MA1631.1	4.45e-07	0.000383
620	MA0522.3	TCF3	MA0522.3	5.41e-07	0.000467
621	MA0763.1	ETV3	MA0763.1	6.22e-07	0.000536
622	MA1966.1	TFAP4::ETV1	MA1966.1	8.07e-07	0.000696
623	MA1535.1	NR2C1	MA1535.1	1.03e-06	0.000891
624	MA0499.2	MYOD1	MA0499.2	1.09e-06	0.000936
625	MA1979.1	ZNF416	MA1979.1	1.1e-06	0.000946
626	MA0062.3	GABPA	MA0062.3	1.21e-06	0.00104
627	MA0625.2	NFATC3	MA0625.2	1.21e-06	0.00104
628	MA0774.1	MEIS2	MA0774.1	1.27e-06	0.00109
629	MA0745.2	SNAI2	MA0745.2	1.32e-06	0.00114
630	MA0605.2	ATF3	MA0605.2	1.61e-06	0.00139
631	MA1419.1	IRF4	MA1419.1	1.66e-06	0.00143
632	MA0136.3	Elf5	MA0136.3	1.92e-06	0.00166
633	MA0814.2	TFAP2C	MA0814.2	2.38e-06	0.00205
634	MA1629.1	Zic2	MA1629.1	3.24e-06	0.00279
635	MA1565.1	TBX18	MA1565.1	7.09e-06	0.00611
636	MA0865.2	E2F8	MA0865.2	1e-05	0.00864
637	MA1604.1	Ebf2	MA1604.1	1.05e-05	0.00909
638	MA1515.1	KLF2	MA1515.1	1.84e-05	0.0158
639	MA0638.1	CREB3	MA0638.1	2.14e-05	0.0185
640	MA1648.1	TCF12	MA1648.1	2.67e-05	0.023
641	MA1554.1	RFX7	MA1554.1	2.98e-05	0.0257
642	MA0048.2	NHLH1	MA0048.2	3.81e-05	0.0328
643	MA1972.1	ZFP14	MA1972.1	3.99e-05	0.0344
644	MA0830.2	TCF4	MA0830.2	4.13e-05	0.0356
645	MA1483.2	ELF2	MA1483.2	4.92e-05	0.0424

LR_open_200xstreme %>%
  dplyr::select(RANK,SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>%
  arrange(.,EVALUE) %>%
   dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>%
  # dplyr::filter(., EVALUE<0.05) %>%
  kable(., caption = "Enriched motifs in LR_open 200bp only") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "800px")

Enriched motifs in LR_open 200bp only
RANK	SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
35	MA0659.3	Mafg	MA0659.3	1.2e-305	1.04e-305
10	MA1130.1	FOSL2::JUN	MA1130.1	1.19e-305	1.05e-305
1	MA1134.1 (FOS::JUNB)	STREME-1	1-DATGASTCATH	1.09e-305	1.09e-305
55	MA0680.2	Pax7	MA0680.2	1.33e-305	1.16e-305
26	MA1142.1	FOSL1::JUND	MA1142.1	1.58e-305	1.39e-305
48	MA0788.1	POU3F3	MA0788.1	1.64e-305	1.44e-305
32	MA0501.1	MAF::NFE2	MA0501.1	1.68e-305	1.46e-305
31	MA0496.3	MAFK	MA0496.3	1.77e-305	1.56e-305
15	MA1633.2	BACH1	MA1633.2	1.89e-305	1.65e-305
50	MA0153.2	HNF1B	MA0153.2	1.99e-305	1.74e-305
16	MA0490.2	JUNB	MA0490.2	2.13e-305	1.86e-305
24	MA0655.1	JDP2	MA0655.1	2.14e-305	1.86e-305
27	MA1101.2	BACH2	MA1101.2	2.17e-305	1.89e-305
47	MA0046.2	HNF1A	MA0046.2	2.16e-305	1.89e-305
7	MA0477.2	FOSL1	MA0477.2	2.29e-305	2.01e-305
41	MA0791.1	POU4F3	MA0791.1	2.37e-305	2.07e-305
13	MA0099.3	FOS::JUN	MA0099.3	2.4e-305	2.11e-305
3	MA1134.1	FOS::JUNB	MA1134.1	2.81e-305	2.45e-305
14	MA0491.2	JUND	MA0491.2	3.13e-305	2.75e-305
52	MA0886.1	EMX2	MA0886.1	3.15e-305	2.75e-305
28	MA1132.1	JUN::JUNB	MA1132.1	3.16e-305	2.79e-305
49	MA0681.2	PHOX2B	MA0681.2	3.32e-305	2.9e-305
17	MA1634.1	BATF	MA1634.1	3.66e-305	3.22e-305
37	MA1113.2	PBX2	MA1113.2	3.86e-305	3.37e-305
51	MA0902.2	HOXB2	MA0902.2	4.01e-305	3.5e-305
44	MA0786.1	POU3F1	MA0786.1	4.17e-305	3.65e-305
36	MA1639.1	MEIS1	MA1639.1	4.24e-305	3.74e-305
60	MA1115.1	POU5F1	MA1115.1	4.34e-305	3.79e-305
19	MA0462.2	BATF::JUN	MA0462.2	4.38e-305	3.81e-305
38	MA0676.1	Nr2e1	MA0676.1	4.68e-305	4.09e-305
9	MA1141.1	FOS::JUND	MA1141.1	5.32e-305	4.64e-305
54	MA0846.1	FOXC2	MA0846.1	5.57e-305	4.86e-305
5	MA0476.1	FOS	MA0476.1	5.63e-305	4.9e-305
23	MA1928.1	BNC2	MA1928.1	5.86e-305	5.16e-305
2	MA1144.1	FOSL2::JUND	MA1144.1	5.93e-305	5.22e-305
22	MA1137.1	FOSL1::JUNB	MA1137.1	6.36e-305	5.54e-305
62	MA0679.2	ONECUT1	MA0679.2	7.01e-305	6.12e-305
64	MA0787.1	POU3F2	MA0787.1	7.21e-305	6.3e-305
11	MA0489.2	Jun	MA0489.2	7.2e-305	6.34e-305
56	MA0785.1	POU2F1	MA0785.1	7.29e-305	6.37e-305
58	MA1487.2	FOXE1	MA1487.2	7.53e-305	6.58e-305
59	MA0789.1	POU3F4	MA0789.1	7.6e-305	6.64e-305
29	MA0841.1	NFE2	MA0841.1	7.56e-305	6.65e-305
42	MA1640.1	MEIS2	MA1640.1	7.76e-305	6.78e-305
18	MA1988.1	Atf3	MA1988.1	8.29e-305	7.3e-305
4	MA1138.1	FOSL2::JUNB	MA1138.1	8.36e-305	7.36e-305
20	MA0835.2	BATF3	MA0835.2	8.75e-305	7.62e-305
12	MA1128.1	FOSL1::JUN	MA1128.1	9.06e-305	7.9e-305
21	MA0478.1	FOSL2	MA0478.1	9.16999999999999e-305	8.07e-305
39	MA0790.1	POU4F1	MA0790.1	9.46e-305	8.26e-305
57	MA0591.1	Bach1::Mafk	MA0591.1	9.65e-305	8.43e-305
34	MA0150.2	Nfe2l2	MA0150.2	9.69999999999999e-305	8.45e-305
46	MA0142.1	Pou5f1::Sox2	MA0142.1	9.81e-305	8.57e-305
63	MA0792.1	POU5F1B	MA0792.1	9.90999999999999e-305	8.66e-305
53	MA0627.2	POU2F3	MA0627.2	9.99999999999999e-306	8.76e-305
30	MA0089.2	MAFG::NFE2L1	MA0089.2	1.05e-305	9.14999999999999e-305
8	MA1135.1	FOSB::JUNB	MA1135.1	1.08e-305	9.51999999999999e-305
43	MA0845.1	FOXB1	MA0845.1	1.09e-305	9.53e-305
40	MA1978.1	ZNF354A	MA1978.1	1.1e-305	9.57e-305
65	MA1143.1	FOSL1::JUND	MA1143.1	7e-303	6.11e-300
66	MA0032.2	FOXC1	MA0032.2	1.43e-295	1.25e-292
67	MA1963.1	SATB1	MA1963.1	3.33e-294	2.92e-291
69	MA0628.1	POU6F1	MA0628.1	4.21e-291	3.68e-288
70	MA0041.2	FOXD3	MA0041.2	1.21e-286	1.06e-283
71	MA1124.1	ZNF24	MA1124.1	1.62e-281	1.42e-278
72	MA0611.2	Dux	MA0611.2	2.29e-274	2e-271
74	MA0715.1	PROP1	MA0715.1	8.64e-270	7.56e-267
75	MA0851.1	Foxj3	MA0851.1	4.74e-269	4.14e-266
76	MA1471.1	BARX2	MA1471.1	3.05e-267	2.67e-264
77	MA0084.1	SRY	MA0084.1	9.72999999999999e-267	8.51e-264
78	MA1606.1	Foxf1	MA1606.1	1.23e-266	1.08e-263
79	MA1603.1	Dmrt1	MA1603.1	1.65e-266	1.44e-263
80	MA0148.4	FOXA1	MA0148.4	1.73e-266	1.51e-263
81	MA1607.1	Foxl2	MA1607.1	8.15e-266	7.12e-263
82	MA0713.1	PHOX2A	MA0713.1	1.06e-265	9.26e-263
83	MA1974.1	ZNF211	MA1974.1	2.44e-265	2.13e-262
84	MA0052.4	MEF2A	MA0052.4	3.03e-265	2.65e-262
85	MA0025.2	NFIL3	MA0025.2	2.4e-264	2.1e-261
86	MA1549.1	POU6F1	MA1549.1	3.71e-263	3.25e-260
87	MA0602.1	Arid5a	MA0602.1	3.46e-262	3.02e-259
89	MA0793.1	POU6F2	MA0793.1	1.66e-258	1.45e-255
90	MA0601.1	Arid3b	MA0601.1	1.18e-257	1.03e-254
91	MA0612.2	EMX1	MA0612.2	6.8e-257	5.95e-254
92	MA0722.1	VAX1	MA0722.1	3.41e-255	2.98e-252
93	MA0847.3	FOXD2	MA0847.3	1.32e-252	1.15e-249
94	MA0901.2	HOXB13	MA0901.2	6.73e-251	5.89e-248
95	MA0613.1	FOXG1	MA0613.1	1.34e-246	1.17e-243
96	MA0910.2	HOXD8	MA0910.2	1.52e-245	1.33e-242
97	MA0723.2	VAX2	MA0723.2	4.09e-245	3.58e-242
98	MA0158.2	HOXA5	MA0158.2	7.57e-245	6.62e-242
99	MA0908.1	HOXD11	MA0908.1	1.07e-239	9.37e-237
100	MA0495.3	MAFF	MA0495.3	2.34e-238	2.04e-235
101	MA0710.1	NOTO	MA0710.1	2.47e-238	2.16e-235
102	MA1502.1	HOXB8	MA1502.1	3.27e-238	2.86e-235
103	MA1636.1	CEBPG	MA1636.1	6.29e-238	5.49e-235
104	MA0706.1	MEOX2	MA0706.1	3e-236	2.63e-233
105	MA0614.1	Foxj2	MA0614.1	2.71e-234	2.37e-231
106	MA0707.2	MNX1	MA0707.2	7.25e-230	6.34e-227
107	MA0031.1	FOXD1	MA0031.1	2.68e-225	2.34e-222
108	MA0849.1	FOXO6	MA0849.1	1.4e-224	1.23e-221
110	MA0724.1	VENTX	MA0724.1	1.82e-223	1.59e-220
111	MA0700.2	LHX2	MA0700.2	1.02e-222	8.92e-220
112	MA0047.3	FOXA2	MA0047.3	3.58e-222	3.13e-219
113	MA0043.3	HLF	MA0043.3	3.01e-221	2.63e-218
114	MA0132.2	PDX1	MA0132.2	3.46e-221	3.02e-218
115	MA0497.1	MEF2C	MA0497.1	4.47e-221	3.91e-218
116	MA0903.1	HOXB3	MA0903.1	3.25e-220	2.84e-217
117	MA1505.1	HOXC8	MA1505.1	4.87e-220	4.25e-217
118	MA0465.2	CDX2	MA0465.2	2.39e-219	2.09e-216
120	MA1495.1	HOXA1	MA1495.1	3.38e-218	2.95e-215
121	MA1152.1	SOX15	MA1152.1	3.74e-218	3.27e-215
122	MA0654.1	ISX	MA0654.1	8.74999999999999e-217	7.65e-214
123	MA0042.2	FOXI1	MA0042.2	9.62999999999999e-217	8.42e-214
124	MA1125.1	ZNF384	MA1125.1	1.36e-216	1.19e-213
125	MA0675.1	NKX6-2	MA0675.1	5.76e-216	5.04e-213
126	MA0035.4	GATA1	MA0035.4	3.12e-215	2.72e-212
127	MA1479.1	DMRTC2	MA1479.1	1.25e-214	1.09e-211
128	MA0674.1	NKX6-1	MA0674.1	1.88e-214	1.65e-211
129	MA0661.1	MEOX1	MA0661.1	5.7e-214	4.98e-211
131	MA0033.2	FOXL1	MA0033.2	2.06e-209	1.8e-206
132	MA0122.3	Nkx3-2	MA0122.3	4.12e-208	3.6e-205
133	MA0905.1	HOXC10	MA0905.1	5.01e-205	4.38e-202
134	MA0701.2	LHX9	MA0701.2	2.84e-204	2.48e-201
135	MA1530.1	NKX6-3	MA1530.1	4.82e-204	4.21e-201
136	MA1463.1	ARGFX	MA1463.1	4.94e-204	4.32e-201
137	MA0718.1	RAX	MA0718.1	3.32e-203	2.9e-200
138	MA0848.1	FOXO4	MA0848.1	3.57e-203	3.12e-200
139	MA1489.1	FOXN3	MA1489.1	5.13e-203	4.48e-200
140	MA0630.1	SHOX	MA0630.1	1.55e-202	1.36e-199
141	MA0102.4	CEBPA	MA0102.4	1.81e-202	1.58e-199
142	MA0650.3	Hoxa13	MA0650.3	2.63e-202	2.3e-199
143	MA0878.3	CDX1	MA0878.3	1.93e-199	1.68e-196
144	MA1519.1	LHX5	MA1519.1	2.79e-199	2.44e-196
145	MA0682.2	PITX1	MA0682.2	3.07e-198	2.68e-195
146	MA0904.2	HOXB5	MA0904.2	3.89e-198	3.4e-195
147	MA0912.2	HOXD3	MA0912.2	2.04e-197	1.78e-194
148	MA1962.1	POU2F1::SOX2	MA1962.1	2.42e-197	2.12e-194
149	MA0899.1	HOXA10	MA0899.1	1.87e-196	1.63e-193
150	MA0644.2	ESX1	MA0644.2	8.66999999999999e-196	7.58e-193
151	MA0658.1	LHX6	MA0658.1	5.02e-195	4.39e-192
152	MA1481.1	DRGX	MA1481.1	9.9e-195	8.65e-192
153	MA0075.3	PRRX2	MA0075.3	1.01e-194	8.82e-192
154	MA0909.3	Hoxd13	MA0909.3	2.72e-194	2.38e-191
155	MA0913.2	HOXD9	MA0913.2	3.79e-194	3.32e-191
156	MA0725.1	VSX1	MA0725.1	1.54e-193	1.35e-190
157	MA1480.1	DPRX	MA1480.1	6.76e-192	5.91e-189
158	MA0709.1	Msx3	MA0709.1	6.05e-191	5.29e-188
159	MA1104.2	GATA6	MA1104.2	2.8e-190	2.45e-187
161	MA1970.1	TRPS1	MA1970.1	6.98e-188	6.1e-185
162	MA0151.1	Arid3a	MA0151.1	1.83e-187	1.6e-184
163	MA0716.1	PRRX1	MA0716.1	2.43e-187	2.12e-184
164	MA0833.2	ATF4	MA0833.2	7.56e-187	6.6e-184
165	MA0125.1	Nobox	MA0125.1	1.51e-186	1.32e-183
166	MA0108.2	TBP	MA0108.2	1.66e-185	1.45e-182
167	MA0892.1	GSX1	MA0892.1	6.9e-185	6.03e-182
168	MA1577.1	TLX2	MA1577.1	3.16e-184	2.76e-181
169	MA0880.1	Dlx3	MA0880.1	4.61e-183	4.03e-180
170	MA1103.2	FOXK2	MA1103.2	4.91e-183	4.29e-180
171	MA0027.2	EN1	MA0027.2	1.53e-182	1.34e-179
172	MA1499.1	HOXB4	MA1499.1	1.73e-182	1.51e-179
173	MA0882.1	DLX6	MA0882.1	4.44e-182	3.88e-179
174	MA0868.2	SOX8	MA0868.2	7.1e-182	6.21e-179
175	MA0726.1	VSX2	MA0726.1	7.92e-182	6.92e-179
176	MA0068.2	PAX4	MA0068.2	7.54e-181	6.59e-178
177	MA1563.2	SOX18	MA1563.2	1.24e-180	1.08e-177
178	MA0704.1	Lhx4	MA0704.1	1.34e-180	1.17e-177
179	MA0881.1	Dlx4	MA0881.1	3.86e-180	3.37e-177
180	MA0036.3	GATA2	MA0036.3	2.91e-179	2.54e-176
181	MA0143.4	SOX2	MA0143.4	3.52e-179	3.07e-176
182	MA0836.2	CEBPD	MA0836.2	9.95e-179	8.7e-176
183	MA0875.1	BARX1	MA0875.1	4.53e-177	3.96e-174
184	MA0481.3	FOXP1	MA0481.3	8.11e-177	7.09e-174
185	MA1683.1	FOXA3	MA1683.1	2.62e-175	2.29e-172
186	MA0040.1	Foxq1	MA0040.1	2.46e-174	2.15e-171
187	MA0755.1	CUX2	MA0755.1	3.54e-174	3.09e-171
188	MA0077.1	SOX9	MA0077.1	7.81e-174	6.82e-171
189	MA0890.1	GBX2	MA0890.1	2.1e-173	1.83e-170
190	MA0720.1	Shox2	MA0720.1	1.09e-171	9.51e-169
191	MA0721.1	UNCX	MA0721.1	1.11e-171	9.66e-169
192	MA0898.1	Hmx3	MA0898.1	7.7e-171	6.73e-168
193	MA0894.1	HESX1	MA0894.1	7.63e-170	6.67e-167
194	MA0717.1	RAX2	MA0717.1	8.06e-169	7.04e-166
195	MA0157.3	Foxo3	MA0157.3	8.09e-169	7.07e-166
196	MA0666.2	MSX1	MA0666.2	2.86e-168	2.5e-165
197	MA0634.1	ALX3	MA0634.1	7.52e-166	6.58e-163
198	MA0900.2	HOXA2	MA0900.2	1.61e-165	1.4e-162
199	MA0874.1	Arx	MA0874.1	2.08e-165	1.82e-162
200	MA0854.1	Alx1	MA0854.1	1.01e-163	8.85e-161
201	MA0885.2	Dlx2	MA0885.2	7.14e-163	6.24e-160
202	MA1657.1	ZNF652	MA1657.1	8.97e-163	7.84e-160
203	MA0662.1	MIXL1	MA0662.1	2.55e-162	2.23e-159
204	MA0876.1	BSX	MA0876.1	2.57e-162	2.25e-159
205	MA0683.1	POU4F2	MA0683.1	1.55e-161	1.35e-158
206	MA1476.2	Dlx5	MA1476.2	6.37e-161	5.57e-158
207	MA1709.1	ZIM3	MA1709.1	6.52e-161	5.7e-158
208	MA0757.1	ONECUT3	MA0757.1	1.61e-160	1.41e-157
209	MA0911.1	Hoxa11	MA0911.1	7.84e-159	6.85e-156
210	MA0889.1	GBX1	MA0889.1	1.16e-158	1.01e-155
211	MA0853.1	Alx4	MA0853.1	2.14e-158	1.87e-155
212	MA0887.1	EVX1	MA0887.1	8.67e-158	7.58e-155
213	MA1504.1	HOXC4	MA1504.1	4.15e-156	3.62e-153
214	MA1498.2	HOXA7	MA1498.2	4.77e-152	4.17e-149
215	MA0705.1	Lhx8	MA0705.1	4.04e-151	3.53e-148
216	MA0708.2	MSX2	MA0708.2	5.91e-151	5.17e-148
217	MA1496.1	HOXA4	MA1496.1	2.09e-150	1.83e-147
218	MA0879.2	DLX1	MA0879.2	1.04e-149	9.05e-147
219	MA0907.1	HOXC13	MA0907.1	9.08e-149	7.94e-146
220	MA1623.1	Stat2	MA1623.1	2.46e-146	2.15e-143
221	MA0618.1	LBX1	MA0618.1	6.23e-146	5.45e-143
222	MA0895.1	HMBOX1	MA0895.1	1.02e-145	8.9e-143
223	MA0037.4	Gata3	MA0037.4	1.33e-144	1.16e-141
224	MA0070.1	PBX1	MA0070.1	6.84e-144	5.97e-141
225	MA0884.2	DUXA	MA0884.2	3.6e-142	3.15e-139
226	MA0754.2	CUX1	MA0754.2	3.75e-142	3.28e-139
227	MA0780.1	PAX3	MA0780.1	9.47e-142	8.28e-139
228	MA1120.1	SOX13	MA1120.1	1.16e-141	1.01e-138
229	MA0442.2	SOX10	MA0442.2	1.52e-141	1.33e-138
230	MA0852.2	FOXK1	MA0852.2	1.56e-141	1.36e-138
231	MA0635.1	BARHL2	MA0635.1	9.17e-139	8.02e-136
232	MA0678.1	OLIG2	MA0678.1	7.49e-137	6.54e-134
233	MA0642.2	EN2	MA0642.2	1.03e-136	9e-134
234	MA0891.1	GSC2	MA0891.1	1.06e-135	9.22e-133
235	MA1707.1	DMRTA1	MA1707.1	3.57e-134	3.12e-131
236	MA1500.1	HOXB6	MA1500.1	6.91e-133	6.04e-130
237	MA0648.1	GSC	MA0648.1	5.33e-132	4.66e-129
238	MA0699.1	LBX2	MA0699.1	9.67e-132	8.45e-129
239	MA0842.2	NRL	MA0842.2	2.6e-131	2.27e-128
240	MA0117.2	Mafb	MA0117.2	7.2e-131	6.29e-128
241	MA1518.2	Lhx1	MA1518.2	9.47e-131	8.28e-128
242	MA1507.1	HOXD4	MA1507.1	1.02e-130	8.93e-128
243	MA0050.3	Irf1	MA0050.3	5.53e-130	4.84e-127
244	MA0850.1	FOXP3	MA0850.1	4.47e-125	3.91e-122
245	MA1562.1	SOX14	MA1562.1	1.2e-124	1.05e-121
246	MA0769.2	TCF7	MA0769.2	1.61e-123	1.41e-120
247	MA1497.1	HOXA6	MA1497.1	2.41e-123	2.1e-120
248	MA0838.1	CEBPG	MA0838.1	3.19e-122	2.79e-119
249	MA0843.1	TEF	MA0843.1	7.38e-122	6.45e-119
250	MA0135.1	Lhx3	MA0135.1	2.37e-121	2.07e-118
251	MA0144.2	STAT3	MA0144.2	1.12e-119	9.77e-117
252	MA0482.2	GATA4	MA0482.2	1.58e-118	1.38e-115
253	MA1608.1	Isl1	MA1608.1	3.83e-118	3.35e-115
254	MA0621.1	mix-a	MA0621.1	2.56e-117	2.24e-114
255	MA0712.2	OTX2	MA0712.2	6.82e-117	5.97e-114
256	MA0523.1	TCF7L2	MA0523.1	7.94e-117	6.94e-114
257	MA0626.1	Npas2	MA0626.1	1.12e-116	9.76e-114
258	MA0606.2	Nfat5	MA0606.2	1.3e-115	1.13e-112
259	MA0593.1	FOXP2	MA0593.1	3.59e-115	3.13e-112
260	MA0893.2	GSX2	MA0893.2	9.27e-115	8.11e-112
261	MA0078.2	Sox17	MA0078.2	1.39e-114	1.22e-111
262	MA0030.1	FOXF2	MA0030.1	1.23e-113	1.08e-110
263	MA0514.2	Sox3	MA0514.2	2.19e-113	1.92e-110
264	MA1960.1	MGA::EVX1	MA1960.1	1.13e-111	9.91e-109
265	MA0906.1	HOXC12	MA0906.1	1.73e-111	1.52e-108
266	MA1729.1	ZNF680	MA1729.1	2.27e-109	1.99e-106
267	MA0480.2	Foxo1	MA0480.2	3.43e-109	3e-106
268	MA0809.2	TEAD4	MA0809.2	1.96e-107	1.72e-104
269	MA0140.2	GATA1::TAL1	MA0140.2	3.01e-107	2.63e-104
270	MA0106.3	TP53	MA0106.3	6.31e-106	5.51e-103
271	MA0766.2	GATA5	MA0766.2	6.37e-105	5.57e-102
272	MA0867.2	SOX4	MA0867.2	1.67e-103	1.46e-100
273	MA1588.1	ZNF136	MA1588.1	3.56e-103	3.11e-100
6	MA1134.1 (FOS::JUNB)	MEME-1	NDRTGASTCA	1.97e-305	1.2e-99
274	MA0896.1	Hmx1	MA0896.1	3.4e-102	2.97e-99
275	MA0520.1	Stat6	MA0520.1	9.49e-102	8.3e-99
276	MA1478.1	DMRTA2	MA1478.1	5.52e-100	4.82e-97
277	MA0888.1	EVX2	MA0888.1	1.47e-98	1.29e-95
278	MA0639.1	DBP	MA0639.1	1.96e-96	1.71e-93
279	MA0897.1	Hmx2	MA0897.1	2.57e-95	2.25e-92
280	MA0468.1	DUX4	MA0468.1	2.97e-95	2.59e-92
281	MA0768.2	Lef1	MA0768.2	7.38e-94	6.45e-91
282	MA0883.1	Dmbx1	MA0883.1	1.24e-93	1.08e-90
283	MA0515.1	Sox6	MA0515.1	1.63e-93	1.43e-90
284	MA0629.1	Rhox11	MA0629.1	2.37e-93	2.07e-90
285	MA1501.1	HOXB7	MA1501.1	2.58e-93	2.25e-90
286	MA1503.1	HOXB9	MA1503.1	2.24e-89	1.96e-86
287	MA0018.4	CREB1	MA0018.4	2.34e-89	2.05e-86
288	MA0784.2	POU1F1	MA0784.2	3.49e-89	3.05e-86
289	MA0483.1	Gfi1B	MA0483.1	4.77e-89	4.17e-86
290	MA0479.1	FOXH1	MA0479.1	9.58e-89	8.38e-86
292	MA0914.1	ISL2	MA0914.1	2.25e-87	1.97e-84
293	MA0837.2	CEBPE	MA0837.2	5.29e-86	4.62e-83
294	MA1119.1	SIX2	MA1119.1	5.82e-86	5.09e-83
295	MA0702.2	LMX1A	MA0702.2	1.39e-85	1.21e-82
296	MA0631.1	Six3	MA0631.1	1.4e-85	1.22e-82
297	MA1632.1	ATF2	MA1632.1	1.03e-83	8.99e-81
298	MA1150.1	RORB	MA1150.1	2.39e-82	2.09e-79
299	MA0711.1	OTX1	MA0711.1	1.3e-81	1.14e-78
300	MA0714.1	PITX3	MA0714.1	3.69e-81	3.22e-78
301	MA0467.2	Crx	MA0467.2	1.12e-80	9.76e-78
302	MA1139.1	FOSL2::JUNB	MA1139.1	2.93e-80	2.56e-77
303	MA1561.1	SOX12	MA1561.1	4.82e-80	4.21e-77
304	MA0095.3	Yy1	MA0095.3	1.48e-79	1.3e-76
305	MA0087.2	Sox5	MA0087.2	5.68e-79	4.96e-76
306	MA0827.1	OLIG3	MA0827.1	1.3e-78	1.14e-75
307	MA0693.3	Vdr	MA0693.3	1.46e-75	1.28e-72
308	MA1580.1	ZBTB32	MA1580.1	7.45e-75	6.51e-72
309	MA0461.2	Atoh1	MA0461.2	4.75e-74	4.15e-71
310	MA0038.2	GFI1	MA0038.2	4.19e-73	3.66e-70
311	MA1126.1	FOS::JUN	MA1126.1	3.09e-72	2.7e-69
312	MA1131.1	FOSL2::JUN	MA1131.1	2.57e-71	2.25e-68
313	MA1118.1	SIX1	MA1118.1	5.54e-70	4.84e-67
314	MA0063.2	NKX2-5	MA0063.2	9.72e-70	8.49e-67
315	MA0873.1	HOXD12	MA0873.1	1.16e-69	1.01e-66
316	MA0877.3	BARHL1	MA0877.3	1.6e-69	1.4e-66
317	MA0507.2	POU2F2	MA0507.2	2.06e-67	1.8e-64
318	MA1520.1	MAF	MA1520.1	2.91e-67	2.55e-64
319	MA0152.2	Nfatc2	MA0152.2	6.03e-67	5.27e-64
320	MA0090.3	TEAD1	MA0090.3	1.29e-66	1.13e-63
321	MA0782.2	PKNOX1	MA0782.2	4.03e-66	3.52e-63
322	MA0861.1	TP73	MA0861.1	4.52e-66	3.95e-63
323	MA1506.1	HOXD10	MA1506.1	2.95e-65	2.58e-62
324	MA0689.1	TBX20	MA0689.1	1.5e-64	1.31e-61
325	MA1127.1	FOSB::JUN	MA1127.1	3.89e-64	3.4e-61
326	MA0620.3	MITF	MA0620.3	1.61e-63	1.41e-60
327	MA0869.2	Sox11	MA0869.2	2.22e-62	1.94e-59
328	MA0029.1	Mecom	MA0029.1	3.19e-62	2.79e-59
329	MA0525.2	TP63	MA0525.2	8.03e-62	7.02e-59
330	MA1991.1	Hnf1A	MA1991.1	2.34e-60	2.05e-57
331	MA1112.2	NR4A1	MA1112.2	1.67e-59	1.46e-56
332	MA0772.1	IRF7	MA0772.1	2.03e-59	1.78e-56
333	MA1994.1	Nkx2-1	MA1994.1	6.51e-58	5.69e-55
68	MA1125.1 (ZNF384)	MEME-2	TTTTTTTTTTTTTTT	7.38e-294	3.2e-54
334	MA0596.1	SREBF2	MA0596.1	7.77e-57	6.79e-54
335	MA1473.1	CDX4	MA1473.1	1.01e-56	8.83e-54
336	MA0069.1	PAX6	MA0069.1	1.4e-55	1.23e-52
337	MA0624.2	Nfatc1	MA0624.2	1.78e-55	1.55e-52
339	MA1145.1	FOSL2::JUND	MA1145.1	2.7e-55	2.36e-52
340	MA0808.1	TEAD3	MA0808.1	1.58e-54	1.38e-51
341	MA0817.1	BHLHE23	MA0817.1	3.45e-53	3.02e-50
342	MA0466.3	CEBPB	MA0466.3	6.53e-53	5.7e-50
343	MA1718.1	ZNF8	MA1718.1	1.15e-52	1.01e-49
344	MA0651.2	HOXC11	MA0651.2	2.46e-52	2.15e-49
345	MA1956.1	FOXO1::FLI1	MA1956.1	4.41e-52	3.86e-49
346	MA1151.1	RORC	MA1151.1	2.94e-51	2.57e-48
347	MA0492.1	JUND	MA0492.1	4.9e-51	4.28e-48
348	MA1720.1	ZNF85	MA1720.1	1.44e-50	1.26e-47
349	MA0773.1	MEF2D	MA0773.1	1.77e-50	1.55e-47
350	MA0619.1	LIN54	MA0619.1	2.37e-50	2.07e-47
351	MA1105.2	GRHL2	MA1105.2	5.87e-50	5.13e-47
352	MA0517.1	STAT1::STAT2	MA0517.1	1.37e-49	1.2e-46
353	MA1953.1	FOXO1::ELF1	MA1953.1	2.22e-49	1.94e-46
354	MA1975.1	ZNF214	MA1975.1	6.42e-49	5.61e-46
355	MA1129.1	FOSL1::JUN	MA1129.1	8.95e-49	7.82e-46
356	MA0826.1	OLIG1	MA0826.1	1.31e-48	1.15e-45
357	MA0488.1	JUN	MA0488.1	5.49e-47	4.8e-44
358	MA0124.2	Nkx3-1	MA0124.2	9.1e-47	7.96e-44
359	MA0829.2	SREBF1	MA0829.2	1.05e-46	9.21e-44
360	MA1108.2	MXI1	MA1108.2	1.06e-46	9.29e-44
361	MA0756.2	ONECUT2	MA0756.2	3.6e-46	3.15e-43
362	MA0594.2	HOXA9	MA0594.2	4.83e-46	4.22e-43
363	MA0660.1	MEF2B	MA0660.1	5.97e-46	5.21e-43
364	MA1989.1	Bcl11B	MA1989.1	8.43e-46	7.37e-43
365	MA1534.1	NR1I3	MA1534.1	8.93e-46	7.81e-43
366	MA0093.3	USF1	MA0093.3	2.6e-45	2.27e-42
367	MA1547.2	PITX2	MA1547.2	3.1e-42	2.71e-39
45	2-ATRYAT	STREME-2	2-ATRYAT	3.94e-305	2.82e-39
369	MA1593.1	ZNF317	MA1593.1	6.77e-41	5.91e-38
371	MA1980.1	ZNF418	MA1980.1	3.7e-39	3.24e-36
372	MA1523.1	MSANTD3	MA1523.1	3.74e-39	3.27e-36
373	MA0595.1	SREBF1	MA0595.1	2.25e-38	1.97e-35
374	MA1421.1	TCF7L1	MA1421.1	2.59e-38	2.26e-35
376	MA0647.1	GRHL1	MA0647.1	4.04e-37	3.53e-34
377	MA1592.1	ZNF274	MA1592.1	4.2e-37	3.67e-34
378	MA1136.1	FOSB::JUNB	MA1136.1	2.04e-36	1.78e-33
379	MA0684.2	RUNX3	MA0684.2	3.58e-35	3.13e-32
380	MA1570.1	TFAP4	MA1570.1	4.87e-35	4.26e-32
381	MA1121.1	TEAD2	MA1121.1	4.92e-35	4.3e-32
383	MA1952.1	FOXJ2::ELF1	MA1952.1	9.13e-35	7.98e-32
384	MA0743.2	SCRT1	MA0743.2	1.08e-34	9.4e-32
386	MA0518.1	Stat4	MA0518.1	3.87e-34	3.38e-31
387	MA0719.1	RHOXF1	MA0719.1	4.19e-34	3.66e-31
388	MA1111.1	NR2F2	MA1111.1	3.63e-33	3.18e-30
389	MA0137.3	STAT1	MA0137.3	3.74e-33	3.27e-30
390	MA1618.1	Ptf1a	MA1618.1	1.18e-32	1.03e-29
391	MA0687.1	SPIC	MA0687.1	1.51e-32	1.32e-29
392	MA0840.1	Creb5	MA0840.1	1.94e-32	1.69e-29
393	MA2001.1	Six4	MA2001.1	2.57e-32	2.25e-29
394	MA0164.1	Nr2e3	MA0164.1	3.14e-32	2.75e-29
61	MA0148.4 (FOXA1)	STREME-3	3-AAACAT	9.96e-305	1.14e-28
395	MA0485.2	HOXC9	MA0485.2	1.59e-31	1.39e-28
399	MA1644.1	NFYC	MA1644.1	1.67e-28	1.46e-25
401	MA1585.1	ZKSCAN1	MA1585.1	1.84e-27	1.61e-24
402	MA0623.2	NEUROG1	MA0623.2	2.36e-27	2.06e-24
404	MA0703.2	LMX1B	MA0703.2	1.99e-26	1.74e-23
33	MA1137.1 (FOSL1::JUNB)	STREME-4	4-ATGACTA	2.59e-305	6e-22
405	MA0072.1	RORA	MA0072.1	8.03e-25	7.01e-22
406	MA0669.1	NEUROG2	MA0669.1	8.84e-25	7.72e-22
407	MA1521.1	MAFA	MA1521.1	1.18e-24	1.03e-21
409	MA0508.3	PRDM1	MA0508.3	5.89e-24	5.15e-21
130	MA0041.2 (FOXD3)	STREME-5	5-AAATAA	3.75e-210	9.88e-21
411	MA1524.2	Msgn1	MA1524.2	1.45e-23	1.27e-20
413	MA0607.2	BHLHA15	MA0607.2	3.42e-23	2.99e-20
414	MA0804.1	TBX19	MA0804.1	3.78e-23	3.3e-20
415	MA0498.2	MEIS1	MA0498.2	6.75e-23	5.9e-20
416	MA1123.2	TWIST1	MA1123.2	1.68e-22	1.47e-19
417	MA0800.1	EOMES	MA0800.1	4.57e-21	3.99e-18
418	MA0519.1	Stat5a::Stat5b	MA0519.1	5.86e-21	5.12e-18
419	MA1624.1	Stat5a	MA1624.1	1.88e-20	1.64e-17
420	MA0494.1	Nr1h3::Rxra	MA0494.1	2.4e-20	2.1e-17
421	MA1594.1	ZNF382	MA1594.1	5.19e-20	4.53e-17
338	MA1547.2 (PITX2)	MEME-3	GCCTGTAATCCCAGC	1.9e-55	4.6e-16
109	6-ATTACA	STREME-6	6-ATTACA	2.12e-224	6.37e-16
422	MA1133.1	JUN::JUNB	MA1133.1	9.86e-19	8.62e-16
423	MA1148.1	PPARA::RXRA	MA1148.1	4.78e-18	4.18e-15
424	TGTGTRTGTGTGTGT	MEME-4	TGTGTRTGTGTGTGT	5.63e-18	5.4e-15
425	MA0802.1	TBR1	MA0802.1	1.19e-17	1.04e-14
426	MA1995.1	Npas4	MA1995.1	1.9e-17	1.66e-14
427	MA0698.1	ZBTB18	MA0698.1	2.81e-17	2.46e-14
428	MA0610.1	DMRT3	MA0610.1	5.11e-17	4.47e-14
73	7-WAGAGAW	STREME-7	7-WAGAGAW	2.09e-272	1.02e-13
429	MA1587.1	ZNF135	MA1587.1	2.62e-16	2.29e-13
431	MA0114.4	HNF4A	MA0114.4	1.31e-15	1.15e-12
432	MA0744.2	SCRT2	MA0744.2	4.1e-15	3.58e-12
433	MA0484.2	HNF4G	MA0484.2	4.28e-15	3.74e-12
434	MA0019.1	Ddit3::Cebpa	MA0019.1	7.23e-15	6.32e-12
436	MA0818.2	BHLHE22	MA0818.2	1.31e-14	1.14e-11
119	8-BTTSAAV	STREME-8	8-BTTSAAV	3.32e-219	2.65e-11
437	MA1114.1	PBX3	MA1114.1	5.01e-14	4.38e-11
438	MA0463.2	BCL6	MA0463.2	1.54e-13	1.34e-10
439	MA0688.1	TBX2	MA0688.1	4.77e-13	4.17e-10
440	MA0770.1	HSF2	MA0770.1	9e-13	7.86e-10
441	MA0071.1	RORA	MA0071.1	1.8e-12	1.57e-09
370	MA1596.1 (ZNF460)	MEME-5	TTTGGGAGGCYGAGG	9.78e-40	1.8e-09
442	MA1525.2	NFATC4	MA1525.2	9.09e-12	7.94e-09
443	MA0656.1	JDP2	MA0656.1	1.39e-11	1.22e-08
444	MA1955.1	FOXO1::ELK3	MA1955.1	1.62e-11	1.42e-08
445	MA0141.3	ESRRB	MA0141.3	2.06e-11	1.8e-08
160	9-AAWWTT	STREME-9	9-AAWWTT	3.17e-188	3.66e-08
446	MA0160.2	NR4A2	MA0160.2	6.65e-11	5.82e-08
447	MA0805.1	TBX1	MA0805.1	1.42e-10	1.24e-07
448	MA0066.1	PPARG	MA0066.1	3.11e-10	2.72e-07
449	MA1155.1	ZSCAN4	MA1155.1	3.81e-10	3.33e-07
450	MA0866.1	SOX21	MA0866.1	5.77e-10	5.04e-07
451	MA1645.1	NKX2-2	MA1645.1	7.49e-10	6.55e-07
452	MA1996.1	Nr1H2	MA1996.1	1.46e-09	1.27e-06
453	MA1468.1	ATOH7	MA1468.1	1.63e-09	1.43e-06
454	MA0486.2	HSF1	MA0486.2	1.83e-09	1.6e-06
455	MA0002.2	Runx1	MA0002.2	2.46e-09	2.15e-06
457	MA1596.1	ZNF460	MA1596.1	3.92e-09	3.43e-06
458	MA0728.1	Nr2F6	MA0728.1	6.05e-09	5.29e-06
460	MA0060.3	NFYA	MA0060.3	7.93e-09	6.93e-06
461	MA0828.2	SREBF2	MA0828.2	9.51e-09	8.31e-06
462	MA1714.1	ZNF675	MA1714.1	1.43e-08	1.25e-05
463	MA0831.3	TFE3	MA0831.3	1.56e-08	1.37e-05
464	MA1625.1	Stat5b	MA1625.1	2.37e-08	2.07e-05
25	MA0476.1 (FOS)	STREME-10	10-TGANTCA	7.22e-305	2.37e-05
88	MA0108.2 (TBP)	STREME-11	11-TWTAWA	2.2e-260	8.9e-05
465	MA1546.1	PAX3	MA1546.1	3.4e-07	0.000297
466	MA0673.1	NKX2-8	MA0673.1	3.88e-07	0.000339
467	MA0870.1	Sox1	MA0870.1	4.78e-07	0.000418
468	MA0797.1	TGIF2	MA0797.1	5.24e-07	0.000458
469	MA0051.1	IRF2	MA0051.1	5.54e-07	0.000485
368	MA1973.1 (ZKSCAN3)	STREME-12	12-CCAGCCTGGGCAACA	3.44e-42	0.000486
397	MA1716.1 (ZNF76)	STREME-13	13-GCACTTTGGGAGGC	4.92e-29	0.000877
470	MA0130.1	ZNF354C	MA0130.1	1.03e-06	0.000897
471	MA1541.1	NR6A1	MA1541.1	1.06e-06	0.00093
472	MA1943.1	ETV2::HOXB13	MA1943.1	1.34e-06	0.00117
473	MA0653.1	IRF9	MA0653.1	1.92e-06	0.00167
474	MA0859.1	Rarg	MA0859.1	2.23e-06	0.00195
475	MA1642.1	NEUROG2	MA1642.1	2.61e-06	0.00228
476	MA1467.2	Atoh1	MA1467.2	2.84e-06	0.00248
477	MA1419.1	IRF4	MA1419.1	2.94e-06	0.00257
478	MA0511.2	RUNX2	MA0511.2	3.07e-06	0.00268
479	MA0009.2	TBXT	MA0009.2	3.33e-06	0.00291
480	MA1950.1	FLI1::FOXI1	MA1950.1	4.38e-06	0.00383
481	MA1937.1	ERF::HOXB13	MA1937.1	5.36e-06	0.00469
412	14-AGTAGCTGG	STREME-14	14-AGTAGCTGG	1.83e-23	0.00473
482	MA1647.2	Prdm4	MA1647.2	5.44e-06	0.00476
483	MA0652.1	IRF8	MA0652.1	8.73e-06	0.00763
484	MA1638.1	HAND2	MA1638.1	9.47e-06	0.00828
396	MA1596.1 (ZNF460)	STREME-15	15-CCTGCCTCAGCCTCC	3.15e-29	0.00982
485	MA0691.1	TFAP4	MA0691.1	1.42e-05	0.0124
382	MA1973.1 (ZKSCAN3)	MEME-6	TGTYGCCCAGGCTGG	6.21e-35	0.013
486	MA0664.1	MLXIPL	MA0664.1	1.49e-05	0.013
487	MA1949.1	FLI1::DRGX	MA1949.1	1.57e-05	0.0137
488	MA0592.3	ESRRA	MA0592.3	1.64e-05	0.0143
400	MA1596.1 (ZNF460)	STREME-17	17-ACCTCTGCCTCCCAG	8.58e-28	0.0245
410	MA1107.2 (KLF9)	STREME-16	16-CACACACAC	8.57e-24	0.0245
398	18-ACACAGGCACAC	STREME-18	18-ACACAGGCACAC	7.04e-29	0.0255
291	MA1989.1 (Bcl11B)	STREME-19	19-AAACCA	1.31e-88	0.027
489	MA0795.1	SMAD3	MA0795.1	3.18e-05	0.0278
490	MA1589.1	ZNF140	MA1589.1	3.45e-05	0.0302
430	20-AGTGCAGTG	STREME-20	20-AGTGCAGTG	5.1e-16	0.0303
456	MA0803.1 (TBX15)	STREME-21	21-ACACTCACAC	3.08e-09	0.0321
491	MA1579.1	ZBTB26	MA1579.1	4.26e-05	0.0373
492	MA0643.1	Esrrg	MA0643.1	4.86e-05	0.0425
375	MA1515.1 (KLF2)	STREME-22	22-CCACCACRCCCRGC	1.4e-37	0.0471
459	MA1990.1 (Gli1)	STREME-23	23-ACACACCACACACA	7.92e-09	0.0525
408	MA1990.1 (Gli1)	STREME-24	24-CACACCACACAC	5.81e-24	0.055
435	25-ACCCACACAC	STREME-25	25-ACCCACACAC	1.06e-14	0.0713
385	MA1973.1 (ZKSCAN3)	STREME-26	26-AGACCAGCCTGGSC	2.71e-34	0.154
403	MA0803.1 (TBX15)	STREME-27	27-AGGTGGGAGGAT	8.18e-27	4.34

LR_close_200xstreme %>% 
  dplyr::select(RANK,SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
  arrange(.,EVALUE) %>%
   dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  # dplyr::filter(., EVALUE<0.05) %>% 
  kable(., caption = "Enriched motifs  in LR close") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "800px")

Enriched motifs in LR close
RANK	SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
3	MA0774.1	MEIS2	MA0774.1	1.5e-109	1.3e-106
6	MA0775.1	MEIS3	MA0775.1	6.73e-67	5.82e-64
8	MA0672.1	NKX2-3	MA0672.1	4.18e-59	3.61e-56
11	MA2003.1	NKX2-4	MA2003.1	4.68e-53	4.05e-50
12	MA0673.1	NKX2-8	MA0673.1	1.63e-52	1.41e-49
325	MA1125.1 (ZNF384)	MEME-1	TTTTTTTTTTTTTTT	0.746	1.8e-47
13	MA0789.1	POU3F4	MA0789.1	6.61e-50	5.72e-47
14	MA0766.2	GATA5	MA0766.2	1.5e-48	1.3e-45
15	MA0498.2	MEIS1	MA0498.2	2.82e-46	2.44e-43
16	MA0792.1	POU5F1B	MA0792.1	3.06e-44	2.64e-41
18	MA0845.1	FOXB1	MA0845.1	1.04e-42	8.98e-40
19	MA0052.4	MEF2A	MA0052.4	1.32e-42	1.14e-39
20	MA0786.1	POU3F1	MA0786.1	1.5e-42	1.29e-39
21	MA0722.1	VAX1	MA0722.1	2.93e-41	2.54e-38
22	MA0124.2	Nkx3-1	MA0124.2	2.44e-40	2.11e-37
24	MA0785.1	POU2F1	MA0785.1	8.52e-40	7.37e-37
25	MA0797.1	TGIF2	MA0797.1	3.67e-39	3.18e-36
26	MA0718.1	RAX	MA0718.1	8.36e-39	7.23e-36
27	MA0720.1	Shox2	MA0720.1	8.88e-39	7.68e-36
28	MA0788.1	POU3F3	MA0788.1	1.08e-38	9.38e-36
29	MA1113.2	PBX2	MA1113.2	1.24e-38	1.08e-35
30	MA0710.1	NOTO	MA0710.1	1.39e-38	1.2e-35
31	MA0787.1	POU3F2	MA0787.1	1.94e-38	1.68e-35
33	MA0671.1	NFIX	MA0671.1	3.39e-38	2.94e-35
34	MA0650.3	Hoxa13	MA0650.3	1.13e-37	9.76e-35
35	MA0627.2	POU2F3	MA0627.2	1.81e-37	1.56e-34
322	MA1723.1 (PRDM9)	MEME-2	GGVAGGGVRRGRRRG	0.00232	1.9e-34
36	MA0670.1	NFIA	MA0670.1	2.8e-37	2.42e-34
37	MA0630.1	SHOX	MA0630.1	3.8e-37	3.29e-34
38	MA0626.1	Npas2	MA0626.1	5.05e-37	4.37e-34
39	MA0704.1	Lhx4	MA0704.1	1.29e-36	1.12e-33
40	MA0725.1	VSX1	MA0725.1	1.82e-36	1.57e-33
41	MA0036.3	GATA2	MA0036.3	1.86e-36	1.61e-33
42	MA1963.1	SATB1	MA1963.1	2.04e-36	1.76e-33
43	MA0031.1	FOXD1	MA0031.1	7.39e-35	6.39e-32
44	MA0809.2	TEAD4	MA0809.2	9.23e-35	7.99e-32
45	MA1104.2	GATA6	MA1104.2	1.42e-34	1.23e-31
46	MA0602.1	Arid5a	MA0602.1	1.82e-34	1.57e-31
47	MA0644.2	ESX1	MA0644.2	1.85e-34	1.6e-31
48	MA0901.2	HOXB13	MA0901.2	2.13e-34	1.84e-31
49	MA0047.3	FOXA2	MA0047.3	3.75e-34	3.24e-31
50	MA0808.1	TEAD3	MA0808.1	3.84e-34	3.33e-31
51	MA0700.2	LHX2	MA0700.2	4.45e-34	3.85e-31
52	MA0092.1	Hand1::Tcf3	MA0092.1	7.46e-34	6.45e-31
53	MA0125.1	Nobox	MA0125.1	9.09e-34	7.87e-31
54	MA0674.1	NKX6-1	MA0674.1	1.2e-33	1.03e-30
55	MA1978.1	ZNF354A	MA1978.1	2.51e-33	2.17e-30
56	MA0790.1	POU4F1	MA0790.1	2.64e-33	2.28e-30
57	MA0846.1	FOXC2	MA0846.1	3.72e-33	3.22e-30
58	MA0084.1	SRY	MA0084.1	5.01e-33	4.33e-30
59	MA0680.2	Pax7	MA0680.2	5.8e-33	5.01e-30
60	MA0142.1	Pou5f1::Sox2	MA0142.1	1.2e-32	1.03e-29
61	MA0882.1	DLX6	MA0882.1	1.56e-32	1.35e-29
62	MA0726.1	VSX2	MA0726.1	4.02e-32	3.47e-29
63	MA0497.1	MEF2C	MA0497.1	4.55e-32	3.93e-29
64	MA0033.2	FOXL1	MA0033.2	4.99e-32	4.31e-29
65	MA0027.2	EN1	MA0027.2	1.08e-31	9.31e-29
67	MA0465.2	CDX2	MA0465.2	1.63e-31	1.41e-28
68	MA1640.1	MEIS2	MA1640.1	2.4e-31	2.07e-28
69	MA0032.2	FOXC1	MA0032.2	4.1e-31	3.54e-28
70	MA1994.1	Nkx2-1	MA1994.1	7.83e-31	6.77e-28
71	MA0709.1	Msx3	MA0709.1	1.45e-30	1.26e-27
72	MA0675.1	NKX6-2	MA0675.1	2.46e-30	2.13e-27
73	MA1115.1	POU5F1	MA1115.1	2.47e-30	2.13e-27
75	MA1481.1	DRGX	MA1481.1	6.93e-30	6e-27
77	MA0077.1	SOX9	MA0077.1	1.96e-29	1.7e-26
78	MA1476.2	Dlx5	MA1476.2	3.61e-29	3.13e-26
79	MA0634.1	ALX3	MA0634.1	7.33e-29	6.34e-26
80	MA0723.2	VAX2	MA0723.2	8.21e-29	7.11e-26
81	MA1563.2	SOX18	MA1563.2	1.22e-28	1.05e-25
82	MA0628.1	POU6F1	MA0628.1	1.45e-28	1.25e-25
83	MA0635.1	BARHL2	MA0635.1	1.84e-28	1.59e-25
84	MA1970.1	TRPS1	MA1970.1	1.94e-28	1.68e-25
85	MA0654.1	ISX	MA0654.1	3.13e-28	2.7e-25
86	MA0793.1	POU6F2	MA0793.1	4.06e-28	3.51e-25
87	MA0880.1	Dlx3	MA0880.1	7.21e-28	6.24e-25
88	MA0890.1	GBX2	MA0890.1	8.73e-28	7.55e-25
89	MA0601.1	Arid3b	MA0601.1	9.82e-28	8.49e-25
90	MA0885.2	Dlx2	MA0885.2	9.96e-28	8.62e-25
91	MA0495.3	MAFF	MA0495.3	1.1e-27	9.49e-25
92	MA1505.1	HOXC8	MA1505.1	3.17e-27	2.74e-24
93	MA0881.1	Dlx4	MA0881.1	3.76e-27	3.25e-24
94	MA1683.1	FOXA3	MA1683.1	7.17e-27	6.2e-24
95	MA1997.1	Olig2	MA1997.1	2.04e-26	1.76e-23
96	MA0894.1	HESX1	MA0894.1	2.27e-26	1.97e-23
97	MA0481.3	FOXP1	MA0481.3	2.66e-26	2.3e-23
98	MA0025.2	NFIL3	MA0025.2	3.08e-26	2.67e-23
99	MA1607.1	Foxl2	MA1607.1	3.73e-26	3.23e-23
100	MA0037.4	Gata3	MA0037.4	6.41e-26	5.55e-23
101	MA0633.2	Twist2	MA0633.2	6.65e-26	5.75e-23
102	MA1993.1	Neurod2	MA1993.1	7.88e-26	6.82e-23
103	MA0132.2	PDX1	MA0132.2	9.28e-26	8.02e-23
104	MA0108.2	TBP	MA0108.2	1.17e-25	1.01e-22
106	MA0739.1	Hic1	MA0739.1	2.34e-25	2.02e-22
107	MA1635.1	BHLHE22	MA1635.1	3.55e-25	3.08e-22
108	MA0681.2	PHOX2B	MA0681.2	4.44e-25	3.84e-22
109	MA0514.2	Sox3	MA0514.2	4.92e-25	4.26e-22
110	MA0666.2	MSX1	MA0666.2	5.24e-25	4.53e-22
111	MA1103.2	FOXK2	MA1103.2	5.48e-25	4.74e-22
112	MA0679.2	ONECUT1	MA0679.2	5.54e-25	4.79e-22
113	MA0148.4	FOXA1	MA0148.4	6.02e-25	5.21e-22
114	MA0848.1	FOXO4	MA0848.1	9.4e-25	8.14e-22
115	MA0889.1	GBX1	MA0889.1	1.06e-24	9.13e-22
116	MA0783.1	PKNOX2	MA0783.1	1.8e-24	1.56e-21
117	MA1606.1	Foxf1	MA1606.1	1.88e-24	1.62e-21
118	MA0899.1	HOXA10	MA0899.1	2.34e-24	2.03e-21
119	MA1120.1	SOX13	MA1120.1	2.88e-24	2.49e-21
120	MA0041.2	FOXD3	MA0041.2	3.48e-24	3.01e-21
121	MA1152.1	SOX15	MA1152.1	3.68e-24	3.18e-21
122	MA0523.1	TCF7L2	MA0523.1	3.98e-24	3.44e-21
123	MA0791.1	POU4F3	MA0791.1	5.14e-24	4.45e-21
124	MA0724.1	VENTX	MA0724.1	7.07e-24	6.11e-21
125	MA1489.1	FOXN3	MA1489.1	7.94e-24	6.86e-21
126	MA0708.2	MSX2	MA0708.2	1.03e-23	8.88e-21
127	MA1471.1	BARX2	MA1471.1	1.36e-23	1.18e-20
128	MA1639.1	MEIS1	MA1639.1	2.21e-23	1.91e-20
129	MA0879.2	DLX1	MA0879.2	2.49e-23	2.15e-20
130	MA0642.2	EN2	MA0642.2	3.06e-23	2.64e-20
131	MA0143.4	SOX2	MA0143.4	4.75e-23	4.11e-20
132	MA0521.2	Tcf12	MA0521.2	7.08e-23	6.13e-20
133	MA0035.4	GATA1	MA0035.4	1.27e-22	1.1e-19
134	MA0769.2	TCF7	MA0769.2	1.89e-22	1.64e-19
135	MA0676.1	Nr2e1	MA0676.1	2.55e-22	2.21e-19
136	MA0886.1	EMX2	MA0886.1	3.26e-22	2.82e-19
137	MA0717.1	RAX2	MA0717.1	3.32e-22	2.87e-19
138	MA0151.1	Arid3a	MA0151.1	5.77e-22	5e-19
139	MA0669.1	NEUROG2	MA0669.1	6.39e-22	5.52e-19
140	MA0119.1	NFIC::TLX1	MA0119.1	6.79e-22	5.88e-19
141	MA0876.1	BSX	MA0876.1	1.42e-21	1.23e-18
142	MA0868.2	SOX8	MA0868.2	1.6e-21	1.39e-18
143	MA1974.1	ZNF211	MA1974.1	2.34e-21	2.02e-18
144	MA1498.2	HOXA7	MA1498.2	3.75e-21	3.24e-18
145	MA0711.1	OTX1	MA0711.1	4.67e-21	4.04e-18
146	MA1502.1	HOXB8	MA1502.1	5.77e-21	4.99e-18
147	MA0614.1	Foxj2	MA0614.1	6.11e-21	5.29e-18
148	MA0716.1	PRRX1	MA0716.1	8.76e-21	7.58e-18
149	MA1643.1	NFIB	MA1643.1	9.17e-21	7.93e-18
150	MA0042.2	FOXI1	MA0042.2	1.25e-20	1.08e-17
151	MA0068.2	PAX4	MA0068.2	2.28e-20	1.97e-17
152	MA0161.2	NFIC	MA0161.2	2.53e-20	2.19e-17
153	MA0706.1	MEOX2	MA0706.1	4.33e-20	3.74e-17
154	MA1112.2	NR4A1	MA1112.2	7.35e-20	6.35e-17
155	MA0713.1	PHOX2A	MA0713.1	9.3e-20	8.05e-17
156	MA0122.3	Nkx3-2	MA0122.3	1.13e-19	9.78e-17
157	MA0078.2	Sox17	MA0078.2	1.17e-19	1.01e-16
158	MA0648.1	GSC	MA0648.1	1.99e-19	1.73e-16
159	MA1121.1	TEAD2	MA1121.1	5.23e-19	4.53e-16
160	MA1608.1	Isl1	MA1608.1	5.72e-19	4.95e-16
161	MA0914.1	ISL2	MA0914.1	7.14e-19	6.18e-16
162	MA0623.2	NEUROG1	MA0623.2	7.84e-19	6.78e-16
163	MA1549.1	POU6F1	MA1549.1	1.29e-18	1.11e-15
164	MA0909.3	Hoxd13	MA0909.3	1.36e-18	1.17e-15
165	MA0461.2	Atoh1	MA0461.2	1.41e-18	1.22e-15
166	MA0910.2	HOXD8	MA0910.2	1.97e-18	1.7e-15
167	MA1497.1	HOXA6	MA1497.1	2.07e-18	1.79e-15
168	MA1636.1	CEBPG	MA1636.1	3.28e-18	2.84e-15
169	MA0618.1	LBX1	MA0618.1	5.01e-18	4.33e-15
170	MA1571.1	TGIF2LX	MA1571.1	5.93e-18	5.13e-15
171	MA0712.2	OTX2	MA0712.2	6.31e-18	5.46e-15
172	MA1562.1	SOX14	MA1562.1	7.96e-18	6.88e-15
173	MA0090.3	TEAD1	MA0090.3	1.84e-17	1.59e-14
175	MA0898.1	Hmx3	MA0898.1	4.26e-17	3.68e-14
176	MA1960.1	MGA::EVX1	MA1960.1	5.11e-17	4.42e-14
177	MA0667.1	MYF6	MA0667.1	6.66e-17	5.76e-14
178	MA0903.1	HOXB3	MA0903.1	1e-16	8.68e-14
179	MA1645.1	NKX2-2	MA1645.1	5.33e-16	4.61e-13
180	MA1619.1	Ptf1A	MA1619.1	5.76e-16	4.98e-13
181	MA0606.2	Nfat5	MA0606.2	6.14e-16	5.31e-13
182	MA0904.2	HOXB5	MA0904.2	1.27e-15	1.1e-12
1	MA0774.1 (MEIS2)	STREME-1	1-STGMCAG	2.05e-148	1.54e-12
183	MA1500.1	HOXB6	MA1500.1	1.8e-15	1.56e-12
184	MA0157.3	Foxo3	MA0157.3	1.88e-15	1.62e-12
185	MA0699.1	LBX2	MA0699.1	2.85e-15	2.47e-12
186	MA1487.2	FOXE1	MA1487.2	3.64e-15	3.15e-12
316	MA0496.3 (MAFK)	MEME-3	RGGCTGRG	3.76e-05	3.2e-12
187	MA0500.2	MYOG	MA0500.2	8.57e-15	7.42e-12
188	MA0063.2	NKX2-5	MA0063.2	9.6e-15	8.3e-12
189	MA0102.4	CEBPA	MA0102.4	9.65e-15	8.34e-12
190	MA0849.1	FOXO6	MA0849.1	1.11e-14	9.63e-12
191	MA1480.1	DPRX	MA1480.1	1.15e-14	9.97e-12
192	MA0887.1	EVX1	MA0887.1	1.4e-14	1.22e-11
193	MA0140.2	GATA1::TAL1	MA0140.2	1.48e-14	1.28e-11
194	MA1657.1	ZNF652	MA1657.1	1.76e-14	1.52e-11
195	MA1501.1	HOXB7	MA1501.1	2.09e-14	1.81e-11
196	MA0721.1	UNCX	MA0721.1	3.17e-14	2.74e-11
197	MA1472.2	Bhlha15	MA1472.2	3.24e-14	2.8e-11
198	MA0826.1	OLIG1	MA0826.1	3.75e-14	3.24e-11
199	MA1504.1	HOXC4	MA1504.1	3.85e-14	3.33e-11
200	MA0682.2	PITX1	MA0682.2	5.53e-14	4.78e-11
201	MA0875.1	BARX1	MA0875.1	6.04e-14	5.23e-11
202	MA1709.1	ZIM3	MA1709.1	6.6e-14	5.7e-11
203	MA0768.2	Lef1	MA0768.2	6.71e-14	5.8e-11
204	MA0892.1	GSX1	MA0892.1	7.57e-14	6.55e-11
2	MA0498.2 (MEIS1)	STREME-2	2-CTGTCADCAC	1.93e-116	8.05e-11
205	MA1479.1	DMRTC2	MA1479.1	1.05e-13	9.11e-11
206	MA0897.1	Hmx2	MA0897.1	1.97e-13	1.71e-10
207	MA0714.1	PITX3	MA0714.1	2.07e-13	1.79e-10
208	MA1593.1	ZNF317	MA1593.1	2.28e-13	1.97e-10
209	MA0816.1	Ascl2	MA0816.1	3.86e-13	3.34e-10
210	MA1707.1	DMRTA1	MA1707.1	4.05e-13	3.5e-10
211	MA0738.1	HIC2	MA0738.1	4.32e-13	3.74e-10
212	MA1468.1	ATOH7	MA1468.1	8.28e-13	7.16e-10
213	MA0877.3	BARHL1	MA0877.3	8.69e-13	7.52e-10
214	MA0802.1	TBR1	MA0802.1	9.31e-13	8.06e-10
215	MA0896.1	Hmx1	MA0896.1	1.03e-12	8.91e-10
216	MA0835.2	BATF3	MA0835.2	1.76e-12	1.52e-09
217	MA1641.1	MYF5	MA1641.1	1.81e-12	1.57e-09
218	MA1495.1	HOXA1	MA1495.1	1.88e-12	1.62e-09
219	MA0847.3	FOXD2	MA0847.3	1.93e-12	1.67e-09
220	MA0091.1	TAL1::TCF3	MA0091.1	2.1e-12	1.82e-09
221	MA1463.1	ARGFX	MA1463.1	2.39e-12	2.07e-09
222	MA0662.1	MIXL1	MA0662.1	2.62e-12	2.27e-09
324	MA1107.2 (KLF9)	MEME-4	GTGTGTGTGTGTGTG	0.651	2.8e-09
223	MA0755.1	CUX2	MA0755.1	3.38e-12	2.92e-09
224	MA0707.2	MNX1	MA0707.2	1.32e-11	1.14e-08
225	MA0018.4	CREB1	MA0018.4	1.43e-11	1.23e-08
226	MA0070.1	PBX1	MA0070.1	1.64e-11	1.42e-08
227	MA0442.2	SOX10	MA0442.2	2.06e-11	1.78e-08
228	MA0715.1	PROP1	MA0715.1	2.68e-11	2.32e-08
229	MA0144.2	STAT3	MA0144.2	3.81e-11	3.3e-08
230	MA0698.1	ZBTB18	MA0698.1	3.91e-11	3.38e-08
231	MA0836.2	CEBPD	MA0836.2	4.16e-11	3.6e-08
232	MA0043.3	HLF	MA0043.3	4.48e-11	3.88e-08
233	MA0850.1	FOXP3	MA0850.1	5.07e-11	4.38e-08
234	MA0607.2	BHLHA15	MA0607.2	6.01e-11	5.19e-08
4	MA0672.1 (NKX2-3)	STREME-3	3-STCAAGTGS	7.96e-82	6.92e-08
235	MA1572.1	TGIF2LY	MA1572.1	8.87e-11	7.67e-08
236	MA1478.1	DMRTA2	MA1478.1	8.88e-11	7.68e-08
237	MA0817.1	BHLHE23	MA0817.1	1.06e-10	9.18e-08
238	MA1530.1	NKX6-3	MA1530.1	1.54e-10	1.33e-07
239	MA1588.1	ZNF136	MA1588.1	1.55e-10	1.34e-07
240	MA0832.1	Tcf21	MA0832.1	1.56e-10	1.35e-07
241	MA0095.3	Yy1	MA0095.3	1.88e-10	1.63e-07
23	4-AWATWT	STREME-4	4-AWATWT	5.35e-40	2.23e-07
242	MA0891.1	GSC2	MA0891.1	3.27e-10	2.83e-07
243	MA0060.3	NFYA	MA0060.3	3.74e-10	3.23e-07
244	MA1991.1	Hnf1A	MA1991.1	4.66e-10	4.03e-07
245	MA0482.2	GATA4	MA0482.2	5.42e-10	4.68e-07
246	MA0867.2	SOX4	MA0867.2	9.75e-10	8.43e-07
247	MA1603.1	Dmrt1	MA1603.1	1.02e-09	8.78e-07
248	MA0827.1	OLIG3	MA0827.1	1.16e-09	1e-06
249	MA0624.2	Nfatc1	MA0624.2	1.38e-09	1.19e-06
250	MA0893.2	GSX2	MA0893.2	1.57e-09	1.36e-06
251	MA1528.1	NFIX	MA1528.1	2.37e-09	2.05e-06
252	MA0597.2	THAP1	MA0597.2	2.51e-09	2.17e-06
253	MA0851.1	Foxj3	MA0851.1	2.54e-09	2.2e-06
254	MA0462.2	BATF::JUN	MA0462.2	2.56e-09	2.22e-06
255	MA0902.2	HOXB2	MA0902.2	2.65e-09	2.29e-06
256	MA0629.1	Rhox11	MA0629.1	3.14e-09	2.72e-06
257	MA0678.1	OLIG2	MA0678.1	3.18e-09	2.75e-06
258	MA0818.2	BHLHE22	MA0818.2	3.4e-09	2.94e-06
259	MA1518.2	Lhx1	MA1518.2	4.34e-09	3.75e-06
260	MA0152.2	Nfatc2	MA0152.2	4.39e-09	3.8e-06
261	MA1634.1	BATF	MA1634.1	4.8e-09	4.15e-06
262	MA0480.2	Foxo1	MA0480.2	5.59e-09	4.83e-06
10	MA1960.1 (MGA::EVX1)	STREME-5	5-TGATAA	1.67e-54	5.13e-06
7	MA0161.2 (NFIC)	STREME-6	6-GCWTGGCA	7.5e-66	5.38e-06
263	MA1644.1	NFYC	MA1644.1	6.72e-09	5.82e-06
264	MA0050.3	Irf1	MA0050.3	7.31e-09	6.32e-06
265	MA1720.1	ZNF85	MA1720.1	8.15e-09	7.05e-06
5	7-SCAGVCA	STREME-7	7-SCAGVCA	5.41e-77	7.45e-06
266	MA1524.2	Msgn1	MA1524.2	1.36e-08	1.18e-05
267	MA0502.2	NFYB	MA0502.2	1.56e-08	1.35e-05
268	MA1975.1	ZNF214	MA1975.1	1.76e-08	1.52e-05
269	MA0158.2	HOXA5	MA0158.2	1.92e-08	1.66e-05
32	MA0769.2 (TCF7)	STREME-8	8-TTCAAA	2.97e-38	1.7e-05
271	MA0833.2	ATF4	MA0833.2	2.13e-08	1.84e-05
272	MA1638.1	HAND2	MA1638.1	2.32e-08	2e-05
273	MA0895.1	HMBOX1	MA0895.1	2.75e-08	2.38e-05
275	MA0911.1	Hoxa11	MA0911.1	3.3e-08	2.85e-05
276	MA0905.1	HOXC10	MA0905.1	3.3e-08	2.85e-05
277	MA0842.2	NRL	MA0842.2	3.38e-08	2.92e-05
278	MA1118.1	SIX1	MA1118.1	3.8e-08	3.28e-05
306	MA0471.2 (E2F6)	MEME-5	CAGGCTGGAGKGCAG	9.7e-06	4.5e-05
279	MA0853.1	Alx4	MA0853.1	6.82e-08	5.9e-05
280	MA0854.1	Alx1	MA0854.1	7.26e-08	6.28e-05
281	MA0852.2	FOXK1	MA0852.2	7.93e-08	6.86e-05
282	MA0805.1	TBX1	MA0805.1	9.89e-08	8.56e-05
283	MA1547.2	PITX2	MA1547.2	1.06e-07	9.2e-05
323	MA1107.2 (KLF9)	MEME-6	TGTGTGTGTGTGTGT	0.168	0.00011
284	MA1573.2	Thap11	MA1573.2	1.31e-07	0.000113
285	MA1623.1	Stat2	MA1623.1	1.44e-07	0.000125
286	MA0900.2	HOXA2	MA0900.2	1.44e-07	0.000125
287	MA1153.1	Smad4	MA1153.1	1.47e-07	0.000127
288	MA1728.1	ZNF549	MA1728.1	1.87e-07	0.000162
289	MA0803.1	TBX15	MA0803.1	1.87e-07	0.000162
290	MA0661.1	MEOX1	MA0661.1	2.72e-07	0.000235
17	MA1645.1 (NKX2-2)	STREME-9	9-CCWCTCA	1.67e-43	0.000328
291	MA0830.2	TCF4	MA0830.2	4.26e-07	0.000368
292	MA1114.1	PBX3	MA1114.1	5.05e-07	0.000437
293	MA0160.2	NR4A2	MA0160.2	5.15e-07	0.000445
294	MA0754.2	CUX1	MA0754.2	9.36e-07	0.00081
295	MA1625.1	Stat5b	MA1625.1	9.56e-07	0.000827
296	MA0690.2	TBX21	MA0690.2	1.73e-06	0.0015
297	MA0693.3	Vdr	MA0693.3	1.81e-06	0.00157
298	MA1618.1	Ptf1a	MA1618.1	2.46e-06	0.00213
299	MA0878.3	CDX1	MA0878.3	2.82e-06	0.00244
300	MA1125.1	ZNF384	MA1125.1	3.15e-06	0.00272
174	MA1731.1 (ZNF768)	STREME-10	10-CCAGAG	3.54e-17	0.00332
301	MA1467.2	Atoh1	MA1467.2	4e-06	0.00346
302	MA0668.2	Neurod2	MA0668.2	7.32e-06	0.00633
303	MA0087.2	Sox5	MA0087.2	7.53e-06	0.00652
304	MA1519.1	LHX5	MA1519.1	8.25e-06	0.00714
305	MA1102.2	CTCFL	MA1102.2	9.15e-06	0.00791
9	MA0739.1 (Hic1)	STREME-11	11-TGCCAMT	2.37e-57	0.00824
105	MA0668.2 (Neurod2)	STREME-12	12-ATCTGK	1.65e-25	0.00947
274	13-ATTGGAG	STREME-13	13-ATTGGAG	2.97e-08	0.0102
307	MA0883.1	Dmbx1	MA0883.1	1.43e-05	0.0124
308	MA1953.1	FOXO1::ELF1	MA1953.1	1.64e-05	0.0142
309	MA0860.1	Rarg	MA0860.1	1.66e-05	0.0144
310	MA1108.2	MXI1	MA1108.2	1.7e-05	0.0147
311	MA0719.1	RHOXF1	MA0719.1	1.92e-05	0.0166
312	MA1581.1	ZBTB6	MA1581.1	1.93e-05	0.0167
76	MA0138.2 (REST)	STREME-14	14-CTGTCCA	1.76e-29	0.0168
313	MA0083.3	SRF	MA0083.3	2.47e-05	0.0214
314	MA0907.1	HOXC13	MA0907.1	2.57e-05	0.0222
315	MA0688.1	TBX2	MA0688.1	3.12e-05	0.027
317	MA1567.2	Tbx6	MA1567.2	3.96e-05	0.0343
318	MA1151.1	RORC	MA1151.1	4.02e-05	0.0348
319	MA1124.1	ZNF24	MA1124.1	4.1e-05	0.0355
74	MA0773.1 (MEF2D)	STREME-15	15-AATAGA	3.97e-30	0.0359
320	MA1119.1	SIX2	MA1119.1	4.63e-05	0.04
66	16-AGTGCTR	STREME-16	16-AGTGCTR	1.37e-31	1.19
270	17-TACWGTA	STREME-17	17-TACWGTA	2.12e-08	1.23
321	MA0161.2 (NFIC)	STREME-18	18-TCTTGGCCCA	0.00101	3.92

LR_close_200xstreme %>% 
  dplyr::select(RANK,SIM_MOTIF,ALT_ID, ID,SEA_PVALUE,EVALUE) %>% 
  arrange(.,EVALUE) %>%
   dplyr::mutate_if(is.numeric, funs(as.character(signif(., 3)))) %>%
  # separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  # dplyr::filter(., EVALUE<0.05) %>% 
  kable(., caption = "Enriched motifs in LR close, 200bp") %>%
  kable_paper("striped", full_width = TRUE) %>%
  kable_styling(full_width = FALSE, font_size = 16) %>%
  scroll_box(height = "800px")

Enriched motifs in LR close, 200bp
RANK	SIM_MOTIF	ALT_ID	ID	SEA_PVALUE	EVALUE
3	MA0774.1	MEIS2	MA0774.1	1.5e-109	1.3e-106
6	MA0775.1	MEIS3	MA0775.1	6.73e-67	5.82e-64
8	MA0672.1	NKX2-3	MA0672.1	4.18e-59	3.61e-56
11	MA2003.1	NKX2-4	MA2003.1	4.68e-53	4.05e-50
12	MA0673.1	NKX2-8	MA0673.1	1.63e-52	1.41e-49
325	MA1125.1 (ZNF384)	MEME-1	TTTTTTTTTTTTTTT	0.746	1.8e-47
13	MA0789.1	POU3F4	MA0789.1	6.61e-50	5.72e-47
14	MA0766.2	GATA5	MA0766.2	1.5e-48	1.3e-45
15	MA0498.2	MEIS1	MA0498.2	2.82e-46	2.44e-43
16	MA0792.1	POU5F1B	MA0792.1	3.06e-44	2.64e-41
18	MA0845.1	FOXB1	MA0845.1	1.04e-42	8.98e-40
19	MA0052.4	MEF2A	MA0052.4	1.32e-42	1.14e-39
20	MA0786.1	POU3F1	MA0786.1	1.5e-42	1.29e-39
21	MA0722.1	VAX1	MA0722.1	2.93e-41	2.54e-38
22	MA0124.2	Nkx3-1	MA0124.2	2.44e-40	2.11e-37
24	MA0785.1	POU2F1	MA0785.1	8.52e-40	7.37e-37
25	MA0797.1	TGIF2	MA0797.1	3.67e-39	3.18e-36
26	MA0718.1	RAX	MA0718.1	8.36e-39	7.23e-36
27	MA0720.1	Shox2	MA0720.1	8.88e-39	7.68e-36
28	MA0788.1	POU3F3	MA0788.1	1.08e-38	9.38e-36
29	MA1113.2	PBX2	MA1113.2	1.24e-38	1.08e-35
30	MA0710.1	NOTO	MA0710.1	1.39e-38	1.2e-35
31	MA0787.1	POU3F2	MA0787.1	1.94e-38	1.68e-35
33	MA0671.1	NFIX	MA0671.1	3.39e-38	2.94e-35
34	MA0650.3	Hoxa13	MA0650.3	1.13e-37	9.76e-35
35	MA0627.2	POU2F3	MA0627.2	1.81e-37	1.56e-34
322	MA1723.1 (PRDM9)	MEME-2	GGVAGGGVRRGRRRG	0.00232	1.9e-34
36	MA0670.1	NFIA	MA0670.1	2.8e-37	2.42e-34
37	MA0630.1	SHOX	MA0630.1	3.8e-37	3.29e-34
38	MA0626.1	Npas2	MA0626.1	5.05e-37	4.37e-34
39	MA0704.1	Lhx4	MA0704.1	1.29e-36	1.12e-33
40	MA0725.1	VSX1	MA0725.1	1.82e-36	1.57e-33
41	MA0036.3	GATA2	MA0036.3	1.86e-36	1.61e-33
42	MA1963.1	SATB1	MA1963.1	2.04e-36	1.76e-33
43	MA0031.1	FOXD1	MA0031.1	7.39e-35	6.39e-32
44	MA0809.2	TEAD4	MA0809.2	9.23e-35	7.99e-32
45	MA1104.2	GATA6	MA1104.2	1.42e-34	1.23e-31
46	MA0602.1	Arid5a	MA0602.1	1.82e-34	1.57e-31
47	MA0644.2	ESX1	MA0644.2	1.85e-34	1.6e-31
48	MA0901.2	HOXB13	MA0901.2	2.13e-34	1.84e-31
49	MA0047.3	FOXA2	MA0047.3	3.75e-34	3.24e-31
50	MA0808.1	TEAD3	MA0808.1	3.84e-34	3.33e-31
51	MA0700.2	LHX2	MA0700.2	4.45e-34	3.85e-31
52	MA0092.1	Hand1::Tcf3	MA0092.1	7.46e-34	6.45e-31
53	MA0125.1	Nobox	MA0125.1	9.09e-34	7.87e-31
54	MA0674.1	NKX6-1	MA0674.1	1.2e-33	1.03e-30
55	MA1978.1	ZNF354A	MA1978.1	2.51e-33	2.17e-30
56	MA0790.1	POU4F1	MA0790.1	2.64e-33	2.28e-30
57	MA0846.1	FOXC2	MA0846.1	3.72e-33	3.22e-30
58	MA0084.1	SRY	MA0084.1	5.01e-33	4.33e-30
59	MA0680.2	Pax7	MA0680.2	5.8e-33	5.01e-30
60	MA0142.1	Pou5f1::Sox2	MA0142.1	1.2e-32	1.03e-29
61	MA0882.1	DLX6	MA0882.1	1.56e-32	1.35e-29
62	MA0726.1	VSX2	MA0726.1	4.02e-32	3.47e-29
63	MA0497.1	MEF2C	MA0497.1	4.55e-32	3.93e-29
64	MA0033.2	FOXL1	MA0033.2	4.99e-32	4.31e-29
65	MA0027.2	EN1	MA0027.2	1.08e-31	9.31e-29
67	MA0465.2	CDX2	MA0465.2	1.63e-31	1.41e-28
68	MA1640.1	MEIS2	MA1640.1	2.4e-31	2.07e-28
69	MA0032.2	FOXC1	MA0032.2	4.1e-31	3.54e-28
70	MA1994.1	Nkx2-1	MA1994.1	7.83e-31	6.77e-28
71	MA0709.1	Msx3	MA0709.1	1.45e-30	1.26e-27
72	MA0675.1	NKX6-2	MA0675.1	2.46e-30	2.13e-27
73	MA1115.1	POU5F1	MA1115.1	2.47e-30	2.13e-27
75	MA1481.1	DRGX	MA1481.1	6.93e-30	6e-27
77	MA0077.1	SOX9	MA0077.1	1.96e-29	1.7e-26
78	MA1476.2	Dlx5	MA1476.2	3.61e-29	3.13e-26
79	MA0634.1	ALX3	MA0634.1	7.33e-29	6.34e-26
80	MA0723.2	VAX2	MA0723.2	8.21e-29	7.11e-26
81	MA1563.2	SOX18	MA1563.2	1.22e-28	1.05e-25
82	MA0628.1	POU6F1	MA0628.1	1.45e-28	1.25e-25
83	MA0635.1	BARHL2	MA0635.1	1.84e-28	1.59e-25
84	MA1970.1	TRPS1	MA1970.1	1.94e-28	1.68e-25
85	MA0654.1	ISX	MA0654.1	3.13e-28	2.7e-25
86	MA0793.1	POU6F2	MA0793.1	4.06e-28	3.51e-25
87	MA0880.1	Dlx3	MA0880.1	7.21e-28	6.24e-25
88	MA0890.1	GBX2	MA0890.1	8.73e-28	7.55e-25
89	MA0601.1	Arid3b	MA0601.1	9.82e-28	8.49e-25
90	MA0885.2	Dlx2	MA0885.2	9.96e-28	8.62e-25
91	MA0495.3	MAFF	MA0495.3	1.1e-27	9.49e-25
92	MA1505.1	HOXC8	MA1505.1	3.17e-27	2.74e-24
93	MA0881.1	Dlx4	MA0881.1	3.76e-27	3.25e-24
94	MA1683.1	FOXA3	MA1683.1	7.17e-27	6.2e-24
95	MA1997.1	Olig2	MA1997.1	2.04e-26	1.76e-23
96	MA0894.1	HESX1	MA0894.1	2.27e-26	1.97e-23
97	MA0481.3	FOXP1	MA0481.3	2.66e-26	2.3e-23
98	MA0025.2	NFIL3	MA0025.2	3.08e-26	2.67e-23
99	MA1607.1	Foxl2	MA1607.1	3.73e-26	3.23e-23
100	MA0037.4	Gata3	MA0037.4	6.41e-26	5.55e-23
101	MA0633.2	Twist2	MA0633.2	6.65e-26	5.75e-23
102	MA1993.1	Neurod2	MA1993.1	7.88e-26	6.82e-23
103	MA0132.2	PDX1	MA0132.2	9.28e-26	8.02e-23
104	MA0108.2	TBP	MA0108.2	1.17e-25	1.01e-22
106	MA0739.1	Hic1	MA0739.1	2.34e-25	2.02e-22
107	MA1635.1	BHLHE22	MA1635.1	3.55e-25	3.08e-22
108	MA0681.2	PHOX2B	MA0681.2	4.44e-25	3.84e-22
109	MA0514.2	Sox3	MA0514.2	4.92e-25	4.26e-22
110	MA0666.2	MSX1	MA0666.2	5.24e-25	4.53e-22
111	MA1103.2	FOXK2	MA1103.2	5.48e-25	4.74e-22
112	MA0679.2	ONECUT1	MA0679.2	5.54e-25	4.79e-22
113	MA0148.4	FOXA1	MA0148.4	6.02e-25	5.21e-22
114	MA0848.1	FOXO4	MA0848.1	9.4e-25	8.14e-22
115	MA0889.1	GBX1	MA0889.1	1.06e-24	9.13e-22
116	MA0783.1	PKNOX2	MA0783.1	1.8e-24	1.56e-21
117	MA1606.1	Foxf1	MA1606.1	1.88e-24	1.62e-21
118	MA0899.1	HOXA10	MA0899.1	2.34e-24	2.03e-21
119	MA1120.1	SOX13	MA1120.1	2.88e-24	2.49e-21
120	MA0041.2	FOXD3	MA0041.2	3.48e-24	3.01e-21
121	MA1152.1	SOX15	MA1152.1	3.68e-24	3.18e-21
122	MA0523.1	TCF7L2	MA0523.1	3.98e-24	3.44e-21
123	MA0791.1	POU4F3	MA0791.1	5.14e-24	4.45e-21
124	MA0724.1	VENTX	MA0724.1	7.07e-24	6.11e-21
125	MA1489.1	FOXN3	MA1489.1	7.94e-24	6.86e-21
126	MA0708.2	MSX2	MA0708.2	1.03e-23	8.88e-21
127	MA1471.1	BARX2	MA1471.1	1.36e-23	1.18e-20
128	MA1639.1	MEIS1	MA1639.1	2.21e-23	1.91e-20
129	MA0879.2	DLX1	MA0879.2	2.49e-23	2.15e-20
130	MA0642.2	EN2	MA0642.2	3.06e-23	2.64e-20
131	MA0143.4	SOX2	MA0143.4	4.75e-23	4.11e-20
132	MA0521.2	Tcf12	MA0521.2	7.08e-23	6.13e-20
133	MA0035.4	GATA1	MA0035.4	1.27e-22	1.1e-19
134	MA0769.2	TCF7	MA0769.2	1.89e-22	1.64e-19
135	MA0676.1	Nr2e1	MA0676.1	2.55e-22	2.21e-19
136	MA0886.1	EMX2	MA0886.1	3.26e-22	2.82e-19
137	MA0717.1	RAX2	MA0717.1	3.32e-22	2.87e-19
138	MA0151.1	Arid3a	MA0151.1	5.77e-22	5e-19
139	MA0669.1	NEUROG2	MA0669.1	6.39e-22	5.52e-19
140	MA0119.1	NFIC::TLX1	MA0119.1	6.79e-22	5.88e-19
141	MA0876.1	BSX	MA0876.1	1.42e-21	1.23e-18
142	MA0868.2	SOX8	MA0868.2	1.6e-21	1.39e-18
143	MA1974.1	ZNF211	MA1974.1	2.34e-21	2.02e-18
144	MA1498.2	HOXA7	MA1498.2	3.75e-21	3.24e-18
145	MA0711.1	OTX1	MA0711.1	4.67e-21	4.04e-18
146	MA1502.1	HOXB8	MA1502.1	5.77e-21	4.99e-18
147	MA0614.1	Foxj2	MA0614.1	6.11e-21	5.29e-18
148	MA0716.1	PRRX1	MA0716.1	8.76e-21	7.58e-18
149	MA1643.1	NFIB	MA1643.1	9.17e-21	7.93e-18
150	MA0042.2	FOXI1	MA0042.2	1.25e-20	1.08e-17
151	MA0068.2	PAX4	MA0068.2	2.28e-20	1.97e-17
152	MA0161.2	NFIC	MA0161.2	2.53e-20	2.19e-17
153	MA0706.1	MEOX2	MA0706.1	4.33e-20	3.74e-17
154	MA1112.2	NR4A1	MA1112.2	7.35e-20	6.35e-17
155	MA0713.1	PHOX2A	MA0713.1	9.3e-20	8.05e-17
156	MA0122.3	Nkx3-2	MA0122.3	1.13e-19	9.78e-17
157	MA0078.2	Sox17	MA0078.2	1.17e-19	1.01e-16
158	MA0648.1	GSC	MA0648.1	1.99e-19	1.73e-16
159	MA1121.1	TEAD2	MA1121.1	5.23e-19	4.53e-16
160	MA1608.1	Isl1	MA1608.1	5.72e-19	4.95e-16
161	MA0914.1	ISL2	MA0914.1	7.14e-19	6.18e-16
162	MA0623.2	NEUROG1	MA0623.2	7.84e-19	6.78e-16
163	MA1549.1	POU6F1	MA1549.1	1.29e-18	1.11e-15
164	MA0909.3	Hoxd13	MA0909.3	1.36e-18	1.17e-15
165	MA0461.2	Atoh1	MA0461.2	1.41e-18	1.22e-15
166	MA0910.2	HOXD8	MA0910.2	1.97e-18	1.7e-15
167	MA1497.1	HOXA6	MA1497.1	2.07e-18	1.79e-15
168	MA1636.1	CEBPG	MA1636.1	3.28e-18	2.84e-15
169	MA0618.1	LBX1	MA0618.1	5.01e-18	4.33e-15
170	MA1571.1	TGIF2LX	MA1571.1	5.93e-18	5.13e-15
171	MA0712.2	OTX2	MA0712.2	6.31e-18	5.46e-15
172	MA1562.1	SOX14	MA1562.1	7.96e-18	6.88e-15
173	MA0090.3	TEAD1	MA0090.3	1.84e-17	1.59e-14
175	MA0898.1	Hmx3	MA0898.1	4.26e-17	3.68e-14
176	MA1960.1	MGA::EVX1	MA1960.1	5.11e-17	4.42e-14
177	MA0667.1	MYF6	MA0667.1	6.66e-17	5.76e-14
178	MA0903.1	HOXB3	MA0903.1	1e-16	8.68e-14
179	MA1645.1	NKX2-2	MA1645.1	5.33e-16	4.61e-13
180	MA1619.1	Ptf1A	MA1619.1	5.76e-16	4.98e-13
181	MA0606.2	Nfat5	MA0606.2	6.14e-16	5.31e-13
182	MA0904.2	HOXB5	MA0904.2	1.27e-15	1.1e-12
1	MA0774.1 (MEIS2)	STREME-1	1-STGMCAG	2.05e-148	1.54e-12
183	MA1500.1	HOXB6	MA1500.1	1.8e-15	1.56e-12
184	MA0157.3	Foxo3	MA0157.3	1.88e-15	1.62e-12
185	MA0699.1	LBX2	MA0699.1	2.85e-15	2.47e-12
186	MA1487.2	FOXE1	MA1487.2	3.64e-15	3.15e-12
316	MA0496.3 (MAFK)	MEME-3	RGGCTGRG	3.76e-05	3.2e-12
187	MA0500.2	MYOG	MA0500.2	8.57e-15	7.42e-12
188	MA0063.2	NKX2-5	MA0063.2	9.6e-15	8.3e-12
189	MA0102.4	CEBPA	MA0102.4	9.65e-15	8.34e-12
190	MA0849.1	FOXO6	MA0849.1	1.11e-14	9.63e-12
191	MA1480.1	DPRX	MA1480.1	1.15e-14	9.97e-12
192	MA0887.1	EVX1	MA0887.1	1.4e-14	1.22e-11
193	MA0140.2	GATA1::TAL1	MA0140.2	1.48e-14	1.28e-11
194	MA1657.1	ZNF652	MA1657.1	1.76e-14	1.52e-11
195	MA1501.1	HOXB7	MA1501.1	2.09e-14	1.81e-11
196	MA0721.1	UNCX	MA0721.1	3.17e-14	2.74e-11
197	MA1472.2	Bhlha15	MA1472.2	3.24e-14	2.8e-11
198	MA0826.1	OLIG1	MA0826.1	3.75e-14	3.24e-11
199	MA1504.1	HOXC4	MA1504.1	3.85e-14	3.33e-11
200	MA0682.2	PITX1	MA0682.2	5.53e-14	4.78e-11
201	MA0875.1	BARX1	MA0875.1	6.04e-14	5.23e-11
202	MA1709.1	ZIM3	MA1709.1	6.6e-14	5.7e-11
203	MA0768.2	Lef1	MA0768.2	6.71e-14	5.8e-11
204	MA0892.1	GSX1	MA0892.1	7.57e-14	6.55e-11
2	MA0498.2 (MEIS1)	STREME-2	2-CTGTCADCAC	1.93e-116	8.05e-11
205	MA1479.1	DMRTC2	MA1479.1	1.05e-13	9.11e-11
206	MA0897.1	Hmx2	MA0897.1	1.97e-13	1.71e-10
207	MA0714.1	PITX3	MA0714.1	2.07e-13	1.79e-10
208	MA1593.1	ZNF317	MA1593.1	2.28e-13	1.97e-10
209	MA0816.1	Ascl2	MA0816.1	3.86e-13	3.34e-10
210	MA1707.1	DMRTA1	MA1707.1	4.05e-13	3.5e-10
211	MA0738.1	HIC2	MA0738.1	4.32e-13	3.74e-10
212	MA1468.1	ATOH7	MA1468.1	8.28e-13	7.16e-10
213	MA0877.3	BARHL1	MA0877.3	8.69e-13	7.52e-10
214	MA0802.1	TBR1	MA0802.1	9.31e-13	8.06e-10
215	MA0896.1	Hmx1	MA0896.1	1.03e-12	8.91e-10
216	MA0835.2	BATF3	MA0835.2	1.76e-12	1.52e-09
217	MA1641.1	MYF5	MA1641.1	1.81e-12	1.57e-09
218	MA1495.1	HOXA1	MA1495.1	1.88e-12	1.62e-09
219	MA0847.3	FOXD2	MA0847.3	1.93e-12	1.67e-09
220	MA0091.1	TAL1::TCF3	MA0091.1	2.1e-12	1.82e-09
221	MA1463.1	ARGFX	MA1463.1	2.39e-12	2.07e-09
222	MA0662.1	MIXL1	MA0662.1	2.62e-12	2.27e-09
324	MA1107.2 (KLF9)	MEME-4	GTGTGTGTGTGTGTG	0.651	2.8e-09
223	MA0755.1	CUX2	MA0755.1	3.38e-12	2.92e-09
224	MA0707.2	MNX1	MA0707.2	1.32e-11	1.14e-08
225	MA0018.4	CREB1	MA0018.4	1.43e-11	1.23e-08
226	MA0070.1	PBX1	MA0070.1	1.64e-11	1.42e-08
227	MA0442.2	SOX10	MA0442.2	2.06e-11	1.78e-08
228	MA0715.1	PROP1	MA0715.1	2.68e-11	2.32e-08
229	MA0144.2	STAT3	MA0144.2	3.81e-11	3.3e-08
230	MA0698.1	ZBTB18	MA0698.1	3.91e-11	3.38e-08
231	MA0836.2	CEBPD	MA0836.2	4.16e-11	3.6e-08
232	MA0043.3	HLF	MA0043.3	4.48e-11	3.88e-08
233	MA0850.1	FOXP3	MA0850.1	5.07e-11	4.38e-08
234	MA0607.2	BHLHA15	MA0607.2	6.01e-11	5.19e-08
4	MA0672.1 (NKX2-3)	STREME-3	3-STCAAGTGS	7.96e-82	6.92e-08
235	MA1572.1	TGIF2LY	MA1572.1	8.87e-11	7.67e-08
236	MA1478.1	DMRTA2	MA1478.1	8.88e-11	7.68e-08
237	MA0817.1	BHLHE23	MA0817.1	1.06e-10	9.18e-08
238	MA1530.1	NKX6-3	MA1530.1	1.54e-10	1.33e-07
239	MA1588.1	ZNF136	MA1588.1	1.55e-10	1.34e-07
240	MA0832.1	Tcf21	MA0832.1	1.56e-10	1.35e-07
241	MA0095.3	Yy1	MA0095.3	1.88e-10	1.63e-07
23	4-AWATWT	STREME-4	4-AWATWT	5.35e-40	2.23e-07
242	MA0891.1	GSC2	MA0891.1	3.27e-10	2.83e-07
243	MA0060.3	NFYA	MA0060.3	3.74e-10	3.23e-07
244	MA1991.1	Hnf1A	MA1991.1	4.66e-10	4.03e-07
245	MA0482.2	GATA4	MA0482.2	5.42e-10	4.68e-07
246	MA0867.2	SOX4	MA0867.2	9.75e-10	8.43e-07
247	MA1603.1	Dmrt1	MA1603.1	1.02e-09	8.78e-07
248	MA0827.1	OLIG3	MA0827.1	1.16e-09	1e-06
249	MA0624.2	Nfatc1	MA0624.2	1.38e-09	1.19e-06
250	MA0893.2	GSX2	MA0893.2	1.57e-09	1.36e-06
251	MA1528.1	NFIX	MA1528.1	2.37e-09	2.05e-06
252	MA0597.2	THAP1	MA0597.2	2.51e-09	2.17e-06
253	MA0851.1	Foxj3	MA0851.1	2.54e-09	2.2e-06
254	MA0462.2	BATF::JUN	MA0462.2	2.56e-09	2.22e-06
255	MA0902.2	HOXB2	MA0902.2	2.65e-09	2.29e-06
256	MA0629.1	Rhox11	MA0629.1	3.14e-09	2.72e-06
257	MA0678.1	OLIG2	MA0678.1	3.18e-09	2.75e-06
258	MA0818.2	BHLHE22	MA0818.2	3.4e-09	2.94e-06
259	MA1518.2	Lhx1	MA1518.2	4.34e-09	3.75e-06
260	MA0152.2	Nfatc2	MA0152.2	4.39e-09	3.8e-06
261	MA1634.1	BATF	MA1634.1	4.8e-09	4.15e-06
262	MA0480.2	Foxo1	MA0480.2	5.59e-09	4.83e-06
10	MA1960.1 (MGA::EVX1)	STREME-5	5-TGATAA	1.67e-54	5.13e-06
7	MA0161.2 (NFIC)	STREME-6	6-GCWTGGCA	7.5e-66	5.38e-06
263	MA1644.1	NFYC	MA1644.1	6.72e-09	5.82e-06
264	MA0050.3	Irf1	MA0050.3	7.31e-09	6.32e-06
265	MA1720.1	ZNF85	MA1720.1	8.15e-09	7.05e-06
5	7-SCAGVCA	STREME-7	7-SCAGVCA	5.41e-77	7.45e-06
266	MA1524.2	Msgn1	MA1524.2	1.36e-08	1.18e-05
267	MA0502.2	NFYB	MA0502.2	1.56e-08	1.35e-05
268	MA1975.1	ZNF214	MA1975.1	1.76e-08	1.52e-05
269	MA0158.2	HOXA5	MA0158.2	1.92e-08	1.66e-05
32	MA0769.2 (TCF7)	STREME-8	8-TTCAAA	2.97e-38	1.7e-05
271	MA0833.2	ATF4	MA0833.2	2.13e-08	1.84e-05
272	MA1638.1	HAND2	MA1638.1	2.32e-08	2e-05
273	MA0895.1	HMBOX1	MA0895.1	2.75e-08	2.38e-05
275	MA0911.1	Hoxa11	MA0911.1	3.3e-08	2.85e-05
276	MA0905.1	HOXC10	MA0905.1	3.3e-08	2.85e-05
277	MA0842.2	NRL	MA0842.2	3.38e-08	2.92e-05
278	MA1118.1	SIX1	MA1118.1	3.8e-08	3.28e-05
306	MA0471.2 (E2F6)	MEME-5	CAGGCTGGAGKGCAG	9.7e-06	4.5e-05
279	MA0853.1	Alx4	MA0853.1	6.82e-08	5.9e-05
280	MA0854.1	Alx1	MA0854.1	7.26e-08	6.28e-05
281	MA0852.2	FOXK1	MA0852.2	7.93e-08	6.86e-05
282	MA0805.1	TBX1	MA0805.1	9.89e-08	8.56e-05
283	MA1547.2	PITX2	MA1547.2	1.06e-07	9.2e-05
323	MA1107.2 (KLF9)	MEME-6	TGTGTGTGTGTGTGT	0.168	0.00011
284	MA1573.2	Thap11	MA1573.2	1.31e-07	0.000113
285	MA1623.1	Stat2	MA1623.1	1.44e-07	0.000125
286	MA0900.2	HOXA2	MA0900.2	1.44e-07	0.000125
287	MA1153.1	Smad4	MA1153.1	1.47e-07	0.000127
288	MA1728.1	ZNF549	MA1728.1	1.87e-07	0.000162
289	MA0803.1	TBX15	MA0803.1	1.87e-07	0.000162
290	MA0661.1	MEOX1	MA0661.1	2.72e-07	0.000235
17	MA1645.1 (NKX2-2)	STREME-9	9-CCWCTCA	1.67e-43	0.000328
291	MA0830.2	TCF4	MA0830.2	4.26e-07	0.000368
292	MA1114.1	PBX3	MA1114.1	5.05e-07	0.000437
293	MA0160.2	NR4A2	MA0160.2	5.15e-07	0.000445
294	MA0754.2	CUX1	MA0754.2	9.36e-07	0.00081
295	MA1625.1	Stat5b	MA1625.1	9.56e-07	0.000827
296	MA0690.2	TBX21	MA0690.2	1.73e-06	0.0015
297	MA0693.3	Vdr	MA0693.3	1.81e-06	0.00157
298	MA1618.1	Ptf1a	MA1618.1	2.46e-06	0.00213
299	MA0878.3	CDX1	MA0878.3	2.82e-06	0.00244
300	MA1125.1	ZNF384	MA1125.1	3.15e-06	0.00272
174	MA1731.1 (ZNF768)	STREME-10	10-CCAGAG	3.54e-17	0.00332
301	MA1467.2	Atoh1	MA1467.2	4e-06	0.00346
302	MA0668.2	Neurod2	MA0668.2	7.32e-06	0.00633
303	MA0087.2	Sox5	MA0087.2	7.53e-06	0.00652
304	MA1519.1	LHX5	MA1519.1	8.25e-06	0.00714
305	MA1102.2	CTCFL	MA1102.2	9.15e-06	0.00791
9	MA0739.1 (Hic1)	STREME-11	11-TGCCAMT	2.37e-57	0.00824
105	MA0668.2 (Neurod2)	STREME-12	12-ATCTGK	1.65e-25	0.00947
274	13-ATTGGAG	STREME-13	13-ATTGGAG	2.97e-08	0.0102
307	MA0883.1	Dmbx1	MA0883.1	1.43e-05	0.0124
308	MA1953.1	FOXO1::ELF1	MA1953.1	1.64e-05	0.0142
309	MA0860.1	Rarg	MA0860.1	1.66e-05	0.0144
310	MA1108.2	MXI1	MA1108.2	1.7e-05	0.0147
311	MA0719.1	RHOXF1	MA0719.1	1.92e-05	0.0166
312	MA1581.1	ZBTB6	MA1581.1	1.93e-05	0.0167
76	MA0138.2 (REST)	STREME-14	14-CTGTCCA	1.76e-29	0.0168
313	MA0083.3	SRF	MA0083.3	2.47e-05	0.0214
314	MA0907.1	HOXC13	MA0907.1	2.57e-05	0.0222
315	MA0688.1	TBX2	MA0688.1	3.12e-05	0.027
317	MA1567.2	Tbx6	MA1567.2	3.96e-05	0.0343
318	MA1151.1	RORC	MA1151.1	4.02e-05	0.0348
319	MA1124.1	ZNF24	MA1124.1	4.1e-05	0.0355
74	MA0773.1 (MEF2D)	STREME-15	15-AATAGA	3.97e-30	0.0359
320	MA1119.1	SIX2	MA1119.1	4.63e-05	0.04
66	16-AGTGCTR	STREME-16	16-AGTGCTR	1.37e-31	1.19
270	17-TACWGTA	STREME-17	17-TACWGTA	2.12e-08	1.23
321	MA0161.2 (NFIC)	STREME-18	18-TCTTGGCCCA	0.00101	3.92

### selecting just the list of names and checking for expression

All enriched motifs found

This area was for all motifs found in Xstreme analysis using NR peaks as background. #### EAR ##### EAR_open

mrc_palette <- c(
    "EAR_open" = "#F8766D",
    "EAR_close" = "#f6483c",
    "ESR_open" = "#7CAE00",
    "ESR_close" = "#587b00",
    "ESR_C"="grey40",
     "ESR_opcl"="grey40",
    "ESR_D"="tan",
     "ESR_clop"="tan",
     "ESR_OC" = "#6a9500",
     "LR_open" = "#00BFC4",
     "LR_close" = "#008d91",
     "NR" = "#C77CFF"
  )

 spd_EARo<-EAR_open_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_EAR_open %>%
                  # dplyr::rename("SEA_PVALUE"=PVALUE) %>%
                  dplyr::select(RANK,ID:PVALUE)),
            by= c("RANK"="RANK", "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS",  "ID"="ID")) %>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="EAR_open") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name))) 
 
 spd_EARo_200<-EAR_open_200xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_EAR_open_200_p2 %>%
                  anti_join(.,sea_EAR_open_200, by = c("ID"="ID","ALT_ID"="ALT_ID")) %>%
  rbind(sea_EAR_open_200) %>% 
  dplyr::select(DB:LOG_QVALUE)), by= c( "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS","ID"="ID"))%>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="EAR_open") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name))) 
 #### breaks 
spd_EARc <- EAR_close_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_EAR_close %>%
                  # dplyr::rename("SEA_PVALUE"=PVALUE) %>%
                  dplyr::select(RANK,ID:PVALUE)),
            by= c("RANK"="RANK", "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS",  "ID"="ID")) %>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="EAR_close") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name)))

spd_EARc_200 <- EAR_close_200xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_EAR_close_200_p2 %>%
                  anti_join(.,sea_EAR_close_200, by = c("ID"="ID","ALT_ID"="ALT_ID")) %>%
  rbind(sea_EAR_close_200) %>% 
  dplyr::select(DB:LOG_QVALUE)), by= c( "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS","ID"="ID"))%>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="EAR_close") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name)))


##### breaks
spd_ESRo <-ESR_open_xstreme%>%
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_ESR_open %>%
                  # dplyr::rename("SEA_PVALUE"=PVALUE) %>%
                  dplyr::select(RANK,ID:PVALUE)),
            by= c("RANK"="RANK", "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS",  "ID"="ID"))%>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="ESR_open") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name)))

spd_ESRo_200 <-ESR_open_200xstreme%>%
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>%
  dplyr::filter(EVALUE<0.05) %>%
  left_join(., (sea_ESR_open_200_p2 %>%
                  anti_join(.,sea_ESR_open_200, by = c("ID"="ID","ALT_ID"="ALT_ID")) %>%
  rbind(sea_ESR_open_200) %>% 
  dplyr::select(DB:LOG_QVALUE)), by= c( "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS","ID"="ID"))%>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="ESR_open") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name)))

spd_ESRc <- ESR_close_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_ESR_close %>%
                  # dplyr::rename("SEA_PVALUE"=PVALUE) %>%
                  dplyr::select(RANK,ID:PVALUE)),
            by= c("RANK"="RANK", "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS",  "ID"="ID")) %>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="ESR_close") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name)))

spd_ESRc_200 <- ESR_close_200xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_ESR_close_200_p2 %>%
                  anti_join(.,sea_ESR_close_200, by = c("ID"="ID","ALT_ID"="ALT_ID")) %>%
  rbind(sea_ESR_close_200) %>% 
  dplyr::select(DB:LOG_QVALUE)), by= c( "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS","ID"="ID"))%>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="ESR_close") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name)))


spd_ESRoc <-ESR_OC_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_ESR_OC %>%
                  # dplyr::rename("SEA_PVALUE"=PVALUE) %>%
                  dplyr::select(RANK,ID:PVALUE)),
            by= c("RANK"="RANK", "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS",  "ID"="ID")) %>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="ESR_OC") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name)))
#######rbind break too

spd_ESRopcl_200<-ESR_opcl_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_ESR_opcl_200_p2 %>%
                  anti_join(.,sea_ESR_opcl_200, by = c("ID"="ID","ALT_ID"="ALT_ID")) %>%
  rbind(sea_ESR_opcl_200) %>% 
  dplyr::select(DB:LOG_QVALUE)), by= c( "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS","ID"="ID"))%>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="ESR_opcl") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name))) 

###rbind break#####
spd_LRo <-LR_open_xstreme%>%
           mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_LR_open %>%
                  # dplyr::rename("SEA_PVALUE"=PVALUE) %>%
                  dplyr::select(RANK,ID:PVALUE)),
            by= c("RANK"="RANK", "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS",  "ID"="ID")) %>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="LR_open") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,  if_else(is.na(motif_name),ID,motif_name)))

spd_LRo_200 <-LR_open_200xstreme%>%
           mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_LR_open_200_p2 %>%
                  anti_join(.,sea_LR_open_200, by = c("ID"="ID","ALT_ID"="ALT_ID")) %>%
  rbind(sea_LR_open_200) %>% 
  dplyr::select(DB:LOG_QVALUE)), by= c( "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS","ID"="ID"))%>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="LR_open") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,  if_else(is.na(motif_name),ID,motif_name)))
 
### rbind break
spd_LRc <- LR_close_xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_LR_close %>%
                  # dplyr::rename("SEA_PVALUE"=PVALUE) %>%
                  dplyr::select(RANK,ID:PVALUE)),
            by= c("RANK"="RANK", "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS",  "ID"="ID")) %>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="LR_close") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name)))

spd_LRc_200 <- LR_close_200xstreme%>% 
   mutate(CONSENSUS=gsub('[[:digit:]]+-', '', CONSENSUS)) %>% 
  dplyr::filter(EVALUE<0.05) %>% 
  left_join(., (sea_LR_close_200_p2 %>%
                  anti_join(.,sea_LR_close_200, by = c("ID"="ID","ALT_ID"="ALT_ID")) %>%
  rbind(sea_LR_close_200) %>% 
  dplyr::select(DB:LOG_QVALUE)), by= c( "ALT_ID"="ALT_ID", "CONSENSUS"="CONSENSUS","ID"="ID"))%>% 
  separate(SIM_MOTIF, into= c("SIM_MOTIF", "NAME"), sep= " ") %>% 
  mutate(motif_name= gsub("[()]","",NAME), mrc="LR_close") %>%
  mutate(motif_name=
           if_else(is.na(motif_name)&str_detect(SIM_MOTIF,"^M"),ALT_ID,
           if_else(is.na(motif_name),ID,motif_name)))

spec_dataframe <- spd_EARo %>% 
  rbind(spd_EARc) %>% 
  rbind(spd_ESRo) %>%
   rbind(spd_ESRc) %>% 
   rbind(spd_ESRoc) %>% 
   rbind(spd_LRo) %>% 
   rbind(spd_LRc)

spec_dataframe_200 <- spd_EARo_200 %>% 
  rbind(spd_EARc_200) %>% 
  rbind(spd_ESRo_200) %>%
   rbind(spd_ESRc_200) %>%
  rbind(spd_ESRopcl_200) %>% 
   rbind(spd_LRo_200) %>% 
   rbind(spd_LRc_200)

data plots from full sequences

###plotting 
spec_dataframe %>% 
 ggplot(.,aes(x=mrc,y=ENR_RATIO,fill=mrc))+
  geom_boxplot()+ 
   geom_hline(yintercept=1.2, col="red")+
  theme_classic()+
  ylab("Enrichment ratio")+
  ggtitle("Enrichment ratio values across MRC")+
  scale_fill_manual(values=mrc_palette)

spec_dataframe %>% 
  ggplot(., aes(x=ENR_RATIO, fill = mrc))+
  geom_density(aes(alpha=0.4)) +
   theme_classic()+
  xlab("Enrichment ratio")+
  ggtitle("Enrichment ratio histogram MRC")+
  scale_fill_manual(values=mrc_palette)+
  coord_cartesian(xlim=c(1,5))

spec_dataframe %>% 
  # dplyr::filter(mrc=="LR_open") %>% 
  ggplot(., aes(x=mrc, y=-log(base=10,EVALUE), color=mrc))+
    geom_jitter()+
  theme_classic()+
  ylab(expression("-log[10] Evalue"))+
  ggtitle("Significant values across MRC motifs")+
  scale_color_manual(values=mrc_palette)

spec_dataframe %>% 
  # dplyr::filter(mrc=="LR_open") %>% 
  ggplot(., aes(x=ENR_RATIO, y=-log(base=10,EVALUE), color=mrc))+
    geom_point(alpha=0.3)+
  theme_classic()+
  ylab(expression("-log[10] Evalue"))+
  ggtitle("Enrichment ratio against significance")+
  scale_color_manual(values=mrc_palette)

data plots from 200 bp sequences

###plotting 
spec_dataframe_200 %>% 
 ggplot(.,aes(x=mrc,y=ENR_RATIO,fill=mrc))+
  geom_boxplot()+
   geom_hline(yintercept=1.2, col="red")+
  theme_classic()+
  ylab("Enrichment ratio")+
  ggtitle("Enrichment ratio values across MRC_200")+
  scale_fill_manual(values=mrc_palette)

spec_dataframe_200 %>% 
  ggplot(., aes(x=ENR_RATIO, fill = mrc))+
  geom_density(aes(alpha=0.4)) +
  theme_classic()+
  xlab("Enrichment ratio")+
  ggtitle("Enrichment ratio histogram MRC_200")+
  scale_fill_manual(values=mrc_palette)+
  coord_cartesian(xlim=c(1,5))

spec_dataframe_200 %>% 
  # dplyr::filter(mrc=="LR_open") %>% 
  ggplot(., aes(x=mrc, y=-log(base=10,EVALUE.x), color=mrc))+
    geom_jitter()+
  theme_classic()+
  ylab(expression("-log[10] Evalue"))+
  ggtitle("Significant values across MRC motifs_200")+
  scale_color_manual(values=mrc_palette)

spec_dataframe_200 %>% 
  # dplyr::filter(mrc=="LR_open") %>% 
  ggplot(., aes(x=ENR_RATIO, y=-log(base=10,EVALUE.x), color=mrc))+
    geom_point(alpha=0.3)+
  theme_classic()+
  ylab(expression("-log[10] Evalue"))+
  ggtitle("Enrichment ratio against significance_200")+
  scale_color_manual(values=mrc_palette)

The enrichment ratio plot let me know where (sort of) to cut the plots to find the highest enrichment ratios by MRC. We decided that ER ratio is not correlated to the significance of the motif, so first filter will be slicing the top 20 by Evalue out, and the second plot will be what happens when we pull the top most significant representative from the cluster and show overall significance by cluster. (I evaluated the results of clustering by eye, to make sure the most significant (by evalue) of the cluster was called for the second figure) ### EAR bar plots

ER_rat <- 1.5
mrc_type <- "EAR_open"
spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="ELK3",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="ZNF93",paste(motif_name, RANK, sep="_"), if_else(motif_name=="Nrf1",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat))

spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="ELK3",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="ZNF93",paste(motif_name, RANK, sep="_"), if_else(motif_name=="Nrf1",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  # arrange(.,EVALUE) %>%
   slice_head(n=5) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`/2.5), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~.*2.5,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat," merged clusters"))

EAR 200 bp barplots

ER_rat <- 1.5
mrc_type <- "EAR_open"
spec_dataframe_200 %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="ELK3",paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="Nrf1",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat))

spec_dataframe_200%>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>%
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="ELK3",paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^Z*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="Nrf1",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`/1.5), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~.*1.5,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks(200bp)Enrichment ratio:",ER_rat," merged clusters"))

EAR_close

ER_rat <- 1.5
mrc_type <- "EAR_close"
spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="MEIS1",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="ZNF384",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZNF257",paste(motif_name, RANK,sep="_"),motif_name))))%>%
   slice_head(n=40) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat))

spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="MEIS1",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="ZNF384",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZNF257",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>%
  slice_head(n=10) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`/1.25), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~.*1.25,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
   ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat," merged clusters"))

EAR_close 200bp

ER_rat <- 1.5
mrc_type <- "EAR_close"
spec_dataframe_200 %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="MEIS1",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="ZNF384",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZNF257",paste(motif_name, RANK,sep="_"),motif_name))))%>%
   slice_head(n=40) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*1), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks (200bp) Enrichment ratio:",ER_rat))

spec_dataframe_200 %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="MEIS1",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="ZNF384",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZNF257",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
   slice_head(n=5) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`/1.25), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~.*1.25,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
   ggtitle(paste( mrc_type,"response peaks (200bp) Enrichment ratio:",ER_rat," merged clusters"))

ESR

ESR_open

ER_rat <- 1.5
mrc_type <- "ESR_open"
spec_dataframe %>% 
  dplyr::filter(mrc=="ESR_open") %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=
           if_else(str_starts(motif_name,"JUND"),paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^ZN*"),paste(motif_name, RANK, sep="_"),    if_else(motif_name=="ZSCAN4", paste(motif_name, RANK,sep="_"),if_else(motif_name=="KLF9",paste(motif_name,RANK,sep="_"), motif_name)))))%>%
  slice_head(n=40) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette["ESR_open"]) +
  geom_point(aes(x=`TP%`*4), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
   ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat))

spec_dataframe %>% 
  dplyr::filter(mrc=="ESR_open") %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
   mutate(motif_name=
           if_else(str_starts(motif_name,"JUND"),paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^ZN*"),paste(motif_name, RANK, sep="_"),    if_else(motif_name=="ZSCAN4", paste(motif_name, RANK,sep="_"),if_else(motif_name=="KLF9",paste(motif_name,RANK,sep="_"), motif_name)))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
   slice_head(n=10) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette["ESR_open"]) +
   geom_point(aes(x=`TP%`*4), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat," merged motif clusters"))

ER_rat <- 1.5
mrc_type <- "ESR_open"
spec_dataframe_200 %>% 
  dplyr::filter(mrc=="ESR_open") %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name=
           if_else(str_starts(motif_name,"JUND"),paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^ZN*"),paste(motif_name, RANK, sep="_"),    if_else(motif_name=="ZSCAN4", paste(motif_name, RANK,sep="_"),if_else(motif_name=="KLF9",paste(motif_name,RANK,sep="_"), motif_name)))))%>%
  slice_head(n=40) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette["ESR_open"]) +
  geom_point(aes(x=`TP%`*2), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./2,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
   ggtitle(paste( mrc_type,"response peaks 200 bpEnrichment ratio:",ER_rat))

spec_dataframe_200 %>% 
  dplyr::filter(mrc=="ESR_open") %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
   mutate(motif_name=
           if_else(str_starts(motif_name,"JUND"),paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^ZN*"),paste(motif_name, RANK, sep="_"),    if_else(motif_name=="ZSCAN4", paste(motif_name, RANK,sep="_"),if_else(motif_name=="KLF9",paste(motif_name,RANK,sep="_"), motif_name)))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
   slice_head(n=5) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette["ESR_open"]) +
   geom_point(aes(x=`TP%`*1.3), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~./1.3,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste(mrc_type,"response peaks 200bp Enrichment ratio:",ER_rat," merged motif clusters"))

ESR_close

ER_rat <- 1.5
mrc_type <- "ESR_close"
spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^ZN*",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZSCAN4",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  slice_head(n=40) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
 ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat))

spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^ZN*",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZSCAN4",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=10) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`*1.2), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~./1.2,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat," merged motif clusters"))

ER_rat <- 1.5
mrc_type <- "ESR_close"
spec_dataframe_200 %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^ZN*",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZSCAN4",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  slice_head(n=40) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
 ggtitle(paste( mrc_type,"response peaks 200bp Enrichment ratio:",ER_rat))

spec_dataframe_200 %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^ZN*",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZSCAN4",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=10) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`*1.2), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~./1.2,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks 200bp Enrichment ratio:",ER_rat," merged motif clusters"))

spec_dataframe_200 %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>(ER_rat+.1)) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^ZN*",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZSCAN4",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=10) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`/0.5), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~.*0.5,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks 200bp Enrichment ratio:",ER_rat+.1," merged motif clusters"))

ESR_OC

ER_rat <- 1.5
mrc_type <- "ESR_OC"
spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
   mutate(motif_name=
           if_else(str_starts(motif_name,"JUND"),paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^FO*"),paste(motif_name, RANK, sep="_"),    if_else(motif_name=="ZSCAN4", paste(motif_name, RANK,sep="_"),if_else(motif_name=="KLF9",paste(motif_name,RANK,sep="_"), motif_name)))))%>%
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*4), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
 ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat))

spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>1.4) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
   mutate(motif_name=
           if_else(str_starts(motif_name,"JUND"),paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^FO*"),paste(motif_name, RANK, sep="_"),    if_else(motif_name=="ZSCAN4", paste(motif_name, RANK,sep="_"),if_else(motif_name=="KLF9",paste(motif_name,RANK,sep="_"), motif_name)))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`*2), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~./2,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat," merged motif clusters"))

ESR_opcl {C}

ER_rat <- 1.5
mrc_type <- "ESR_opcl"
spec_dataframe_200 %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^ZN*",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZSCAN4",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  slice_head(n=40) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
 ggtitle(paste( mrc_type,"response peaks 200bp Enrichment ratio:",ER_rat))

spec_dataframe_200 %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^ZN*",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZSCAN4",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=10) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`*1.2), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~./1.2,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks 200bp Enrichment ratio:",ER_rat," merged motif clusters"))

spec_dataframe_200 %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>(ER_rat+.1)) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(motif_name=="^ZN*",paste(motif_name, RANK, sep="_"), if_else(motif_name=="ZSCAN4",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=10) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`/3), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~.*3,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks 200bp Enrichment ratio:",ER_rat," merged motif clusters"))

LR

LR_open

ER_rat <- 1.5
mrc_type <- "LR_open"
spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
 mutate(motif_name=
           if_else(str_starts(motif_name,"BATF"),paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^FO*"),paste(motif_name, RANK, sep="_"),    if_else(motif_name=="ZSCAN4", paste(motif_name, RANK,sep="_"),if_else(motif_name=="KLF9",paste(motif_name,RANK,sep="_"), motif_name)))))%>%
  slice_head(n=60) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*4), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
 ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat))

spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=
           if_else(str_starts(motif_name,"BATF"),paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^FO*"),paste(motif_name, RANK, sep="_"),    if_else(motif_name=="ZSCAN4", paste(motif_name, RANK,sep="_"),if_else(motif_name=="KLF9",paste(motif_name,RANK,sep="_"), motif_name)))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
   slice_head(n=10) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`*4), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat," merged motif clusters"))

# spec_dataframe %>% 
#   dplyr::filter(mrc==mrc_type) %>% 
#   dplyr::filter(ENR_RATIO>ER_rat) #%>% 
#   dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)

ER_rat <- 1.5
mrc_type <- "LR_open"
spec_dataframe_200 %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
 mutate(motif_name=
           if_else(str_starts(motif_name,"BATF"),paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^FO*"),paste(motif_name, RANK, sep="_"),    if_else(motif_name=="ZSCAN4", paste(motif_name, RANK,sep="_"),if_else(motif_name=="KLF9",paste(motif_name,RANK,sep="_"), motif_name)))))%>%
  slice_head(n=60) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*4), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./4,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
 ggtitle(paste( mrc_type,"response peaks 200 bp Enrichment ratio:",ER_rat))

spec_dataframe_200 %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name=
           if_else(str_starts(motif_name,"BATF"),paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^FO*"),paste(motif_name, RANK, sep="_"),    if_else(motif_name=="ZSCAN4", paste(motif_name, RANK,sep="_"),if_else(motif_name=="KLF9",paste(motif_name,RANK,sep="_"), motif_name)))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
   slice_head(n=5) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`*5), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~./5,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks 200 bp Enrichment ratio:",ER_rat," merged motif clusters"))

# spec_dataframe %>% 
#   dplyr::filter(mrc==mrc_type) %>% 
#   dplyr::filter(ENR_RATIO>ER_rat) #%>% 
#   dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)

LR_close

ER_rat <- 1.5
mrc_type <- "LR_close"
spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^R*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="PKNOX2",paste(motif_name, RANK,sep="_"),motif_name))))%>%
    slice_head(n=40) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*1.3), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.3,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
 ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat))

spec_dataframe %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE) %>%
  mutate(log10Evalue= log(EVALUE, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^R*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="PKNOX2",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=10) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`*1.3), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~./1.3,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks Enrichment ratio:",ER_rat," merged motif clusters"))

# spec_dataframe %>% 
#   dplyr::filter(mrc==mrc_type) %>% 
#   dplyr::filter(ENR_RATIO>ER_rat) #%>% 
#   dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)

ER_rat <- 1.3
mrc_type <- "LR_close"
spec_dataframe_200 %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^R*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="PKNOX2",paste(motif_name, RANK,sep="_"),motif_name))))%>%
    slice_head(n=40) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
  geom_point(aes(x=`TP%`*1.25), size =4)+
  scale_x_continuous(expand=c (0,.125),sec.axis = sec_axis(transform= ~./1.25,name="Percent of peaks with motif"))+
  theme_classic()+
  ylab("Enriched TF motif")+
 ggtitle(paste( mrc_type,"response peaks 200bp Enrichment ratio:",ER_rat))

spec_dataframe_200 %>% 
  dplyr::filter(mrc==mrc_type) %>% 
  dplyr::filter(ENR_RATIO>ER_rat) %>% 
  dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE.x, TP:'FP%', motif_name)%>%
  arrange(.,EVALUE.x) %>%
  mutate(log10Evalue= log(EVALUE.x, base = 10)*(-1)) %>% 
  mutate(motif_name=if_else(motif_name=="KLF9",paste(motif_name, RANK, sep="_"),             if_else(str_starts(motif_name,"^R*"),paste(motif_name, RANK, sep="_"), if_else(motif_name=="PKNOX2",paste(motif_name, RANK,sep="_"),motif_name))))%>%
  distinct(CLUSTER,.keep_all = TRUE) %>% 
  slice_head(n=5) %>% 
  ggplot(., aes (y= reorder(motif_name,log10Evalue))) +
  geom_col(aes(x=log10Evalue),fill=mrc_palette[mrc_type]) +
   geom_point(aes(x=`TP%`/.4), size =4)+
   # geom_line(aes(x=`TP%`,y= motif_name, group=log10Evalue))+
  scale_x_continuous(expand=c (0,.25),sec.axis = sec_axis(transform= ~.*.4,name="Percent of peaks with motif"))+
  # geom_text(aes())
  theme_classic()+
  ylab("Enriched TF motif")+
  ggtitle(paste( mrc_type,"response peaks 200bp Enrichment ratio:",ER_rat," merged motif clusters"))

# spec_dataframe %>% 
#   dplyr::filter(mrc==mrc_type) %>% 
#   dplyr::filter(ENR_RATIO>ER_rat) #%>% 
#   dplyr::select(RANK,CLUSTER, SITES,SIM_MOTIF,ALT_ID, ID,EVALUE, TP:'FP%', motif_name)

motif and peak section (incomplete)

NR_gr <- import("data/Final_four_data/meme_bed/NR_df.bed")
EAR_open_gr <- import("data/Final_four_data/meme_bed/EAR_open.bed")
EAR_close_gr <- import("data/Final_four_data/meme_bed/EAR_close.bed")
ESR_open_gr <- import("data/Final_four_data/meme_bed/ESR_open.bed")
ESR_OC_gr <- import("data/Final_four_data/meme_bed/ESR_OC.bed")
ESR_close_gr <- import("data/Final_four_data/meme_bed/ESR_close.bed")
LR_open_gr <- import("data/Final_four_data/meme_bed/LR_open.bed")
LR_close_gr <- import("data/Final_four_data/meme_bed/LR_close.bed")
ESR_C_gr <- import("data/Final_four_data/meme_bed/ESR_C.bed")
 
ESR_D_gr <- import("data/Final_four_data/meme_bed/ESR_D.bed")
 
# rtracklayer::export.bed(ESR_D_resized,con = "data/Final_four_data/meme_bed/ESR_D_resized.bed")
ESR_C_resized <- resize(ESR_C_gr, width = 400,fix='center')
ESR_D_resized <- resize(ESR_D_gr, width = 400,fix='center')
EAR_open_resized <- resize(EAR_open_gr, width = 400,fix='center')
ESR_open_resized <- resize(ESR_open_gr, width = 400,fix='center')
LR_open_resized <- resize(LR_open_gr, width = 400,fix='center')
NR_resized <- resize(NR_gr, width = 400,fix='center')

EAR_close_resized <- resize(EAR_close_gr, width = 400,fix='center')
ESR_close_resized <- resize(ESR_close_gr, width = 400,fix='center')
LR_close_resized <- resize(LR_close_gr, width = 400,fix='center')
ESR_OC_resized <- resize(ESR_OC_gr, width = 400,fix='center')



# BiocManager::install('PWMEnrich')

# seq_list_cd <- list(EAR_open_resized=EAR_open_resized,EAR_close_resized=EAR_close_resized,ESR_open_resized=ESR_open_resized,ESR_close_resized=ESR_close_resized,ESR_C_resized=ESR_C_resized,ESR_D_resized=ESR_D_resized,LR_open_resized=LR_open_resized,LR_close_resized=LR_close_resized,NR_resized=NR_resized)



# seq_all_cd_200 <- lapply(seq_list_cd, getSeq, x=BSgenome.Hsapiens.UCSC.hg38)
# seq_all_200

# saveRDS(seq_all_cd_200, "data/Final_four_data/sequencing_cd_200_object8_motif.RDS")
seq_all_200 <- readRDS("data/Final_four_data/sequencing_R200_object8_motif.RDS")
seq_all_cd_200 <- readRDS("data/Final_four_data/sequencing_cd_200_object8_motif.RDS")

NRF1

not redone yet

# 
# motifs_NRF1 = query(query(MotifDb, 'Hsapiens'), 'NRF1')
#     NRF1_motif <- motifs_NRF1$`Hsapiens-jaspar2018-NRF1-MA0506.1`
# # #
# #
# NRF1_pwm = PWMatrix(
#     ID = 'NRF1',
#     profileMatrix = NRF1_motif)
# 
# list_nrf1 = lapply(unlist(seq_all) , FUN=searchSeq, x=NRF1_pwm, min.score="80%", strand="*")
# 
# nrf1storage <- map_dfr(list_nrf1, ~as.data.frame(.x), .id="id")

# saveRDS(nrf1storage, "data/Final_four_data/nrf1_motif_8group.RDS")
nrf1_motif_8group <- readRDS("data/Final_four_data/nrf1_motif_8group.RDS")
nrf1_motif_8group %>%
  mutate(id= gsub("_resized","",id)) %>% 
  dplyr::filter(id =="EAR_open"|id == "NR") %>%
   dplyr::filter(relScore>.90) %>%
  mutate(position=start-500) %>% 
  ggplot(.,aes(position, color = id))+
  geom_density(trim = FALSE,size=1.5) +
  theme_bw() +
  scale_color_manual(values=mrc_palette)+
  ggtitle("NRF1")

spec_dataframe_200 %>% 
  # dplyr::filter(mrc=="LR_close")
  # dplyr::filter(is.na(ENR_RATIO))
  dplyr::filter(stringr::str_detect(motif_name,"Nrf"))#%>%

# A tibble: 3 × 31
  RANK  SEED_MOTIF CLUSTER SOURCE  ID    ALT_ID CONSENSUS WIDTH SITES SEA_PVALUE
  <chr>      <dbl>   <dbl> <chr>   <chr> <chr>  <chr>     <dbl> <dbl>      <dbl>
1 4              1       3 STREME  3-GC… STREM… GCGCCGGC…    10  1193   4.10e-41
2 7              1       6 ../mot… MA05… Nrf1   SNCTGCGC…    15   892   2.82e-38
3 108            0      29 ../mot… MA05… Nrf1   SNCTGCGC…    15  6300   5.32e-24
# ℹ 21 more variables: EVALUE.x <dbl>, EVALUE_ACC <dbl>, SIM_SOURCE <chr>,
#   SIM_MOTIF <chr>, NAME <chr>, MOTIF_URL <chr>, DB <chr>, TP <dbl>,
#   `TP%` <dbl>, FP <dbl>, `FP%` <dbl>, ENR_RATIO <dbl>, SCORE_THR <dbl>,
#   PVALUE <dbl>, LOG_PVALUE <dbl>, EVALUE.y <dbl>, LOG_EVALUE <dbl>,
#   QVALUE <dbl>, LOG_QVALUE <dbl>, motif_name <chr>, mrc <chr>

  # dplyr::select(RANK ,CLUSTER,mrc,motif_name,ID:CONSENSUS,EVALUE,ENR_RATIO,`TP%`)

BACH2

not redone yet

ZNF384

not redone yet

# motifs_ZNF384 = query(query(MotifDb, 'Hsapiens'), 'ZNF384')
# ZNF384_motif <- motifs_ZNF384$`Hsapiens-jaspar2022-ZNF384-MA1125.1`
# #
# #
# ZNF384_pwm = PWMatrix(
#     ID = 'ZNF384',
#     profileMatrix = ZNF384_motif)

# plan(multisession, workers = parallel::detectCores())
# 
# # Apply future_lapply for parallel execution
# znf384_test <- future_lapply(unlist(seq_all), FUN=searchSeq, x=ZNF384_pwm, min.score="80%", strand="*")


# znf384_storage <- rbindlist(znf384_test, idcol="id")
# site_data_tables <- lapply(znf384_test, function(x) {
  # as.data.table(as.data.frame(x))  # Convert to data table for more efficiency
# })
# znf384_storage <- future_lapply(znf384_test, as.data.frame)
# znf384_storage <- rbindlist(site_data_tables, idcol="id",fill = TRUE)

# znf384_storage <- map_dfr(znf384_test, ~as.data.frame(.x), .id="id")
# Shut down workers once done
# plan(sequential)
# saveRDS(znf384_storage, "data/Final_four_data/znf384_motif_8group.RDS")
znf384_motif_8group <- readRDS("data/Final_four_data/znf384_motif_8group.RDS")
znf384_motif_8group %>%
  mutate(id= gsub("_resized","",id)) %>% 
  # dplyr::filter(id =="EAR_open"|id == "NR"|id=="EAR_close") %>% 
  dplyr::filter(relScore>0.9) %>%
  mutate(position=start-500) %>% 
  ggplot(.,aes(position, color = id))+
  geom_density(trim = FALSE,size=1.5) +
  theme_bw() +
  scale_color_manual(values=mrc_palette)+
  ggtitle("ZNF384 motif")

spec_dataframe %>% 
  # dplyr::filter(mrc=="LR_close")
  # dplyr::filter(is.na(ENR_RATIO))
  dplyr::filter(stringr::str_detect( motif_name,"ZNF384")) %>% 
  dplyr::select(RANK ,CLUSTER,mrc,motif_name,ID:CONSENSUS,EVALUE,ENR_RATIO,`TP%`)

# A tibble: 10 × 10
   RANK  CLUSTER mrc       motif_name ID    ALT_ID CONSENSUS    EVALUE ENR_RATIO
   <chr>   <dbl> <chr>     <chr>      <chr> <chr>  <chr>         <dbl>     <dbl>
 1 133        31 EAR_close ZNF384     7-GT… STREM… GTCTCWAA… 3.83e-  3      2.27
 2 330        68 EAR_close ZNF384     WTTT… MEME-1 WTTTTTTT… 1.5 e- 48      1.61
 3 425        64 EAR_close ZNF384     MA11… ZNF384 DNWMAAAA… 3.96e-  5      1.06
 4 100        13 ESR_open  ZNF384     TWTT… MEME-1 TWTTTTTT… 4.30e- 44     NA   
 5 327        93 ESR_close ZNF384     AAAA… MEME-2 AAAAAAAA… 3   e- 18     NA   
 6 68         15 ESR_OC    ZNF384     TTTT… MEME-2 TTTTTTTT… 3.20e- 54     NA   
 7 124        26 ESR_OC    ZNF384     MA11… ZNF384 DNWMAAAA… 1.19e-213     NA   
 8 83         23 LR_open   ZNF384     AAAW… MEME-1 AAAWAAAA… 6   e- 73      1.2 
 9 232        41 LR_open   ZNF384     MA11… ZNF384 DNWMAAAA… 2.90e-133      1.12
10 489       102 LR_close  ZNF384     AAAW… MEME-1 AAAWAAAA… 1.5 e- 21     NA   
# ℹ 1 more variable: `TP%` <dbl>

ELK3

not redone yet

# motifs_ELK3 = query(query(MotifDb, 'Hsapiens'), 'ELK3')
#     ELK3_motif <- motifs_ELK3$`Hsapiens-jaspar2022-ELK3-MA0759.2`
#     # #
# # #
# ELK3_pwm = PWMatrix(
#     ID = 'ELK3',
#     profileMatrix = ELK3_motif)
# ELK3_test = lapply(unlist(seq_all) , FUN=searchSeq, x=ELK3_pwm, min.score="80%", strand="*")
# # 
# 
# ELK3_storage <- map_dfr(ELK3_test, ~as.data.frame(.x), .id="id")

# saveRDS(ELK3_storage, "data/Final_four_data/ELK3_motif_8group.RDS")
ELK3_motif_8group <- readRDS("data/Final_four_data/ELK3_motif_8group.RDS")
ELK3_motif_8group %>%
  mutate(id= gsub("_resized","",id)) %>% 
  # dplyr::filter(id =="EAR_open"|id == "NR"|id=="EAR_close") %>%
  dplyr::filter(relScore>0.9) %>%
  mutate(position=start-500) %>% 
  ggplot(.,aes(position, color = id))+
  geom_density(trim = FALSE,size=1.5) +
  theme_bw() +
  scale_color_manual(values=mrc_palette)+
  ggtitle("ELK3 motif")

spec_dataframe %>% 
  dplyr::filter(stringr::str_detect( motif_name,"ELK^*")) %>% 
  dplyr::select(RANK ,CLUSTER,mrc,motif_name,ID:CONSENSUS,EVALUE,ENR_RATIO,`TP%`)

# A tibble: 13 × 10
   RANK  CLUSTER mrc       motif_name  ID    ALT_ID CONSENSUS   EVALUE ENR_RATIO
   <chr>   <dbl> <chr>     <chr>       <chr> <chr>  <chr>        <dbl>     <dbl>
 1 2           1 EAR_open  ELK1        MA00… ELK1   ACCGGAAG… 8.47e-18      2.44
 2 3           1 EAR_open  ELK3        MA07… ELK3   ACCGGAAG… 3.09e-17      2.46
 3 26          1 EAR_open  ELK1::HOXA1 MA19… ELK1:… ACCGGAAG… 3.82e- 5      1.95
 4 39          1 EAR_open  ELK1::SREB… MA19… ELK1:… DCCGGAAG… 2.03e- 3      3.84
 5 50          1 EAR_open  ELK1::HOXB… MA19… ELK1:… ACCGGAAG… 2.85e- 2      1.66
 6 453        44 EAR_close FOXO1::ELK1 MA19… FOXO1… RWMAACAG… 1.01e- 4      1.05
 7 491        44 EAR_close ELK4        MA00… ELK4   BCRCTTCC… 5.57e- 4      1.06
 8 526        44 EAR_close HOXB2::ELK1 MA19… HOXB2… RCCGGAAG… 4.56e- 3      1.06
 9 444        40 ESR_OC    FOXO1::ELK3 MA19… FOXO1… RWMAACAG… 1.42e- 8     NA   
10 470        58 LR_open   FOXO1::ELK3 MA19… FOXO1… RWMAACAG… 2.33e-25      1.04
11 504        58 LR_open   FOXO1::ELK1 MA19… FOXO1… RWMAACAG… 1.46e-17      1.05
12 518        29 LR_open   HOXD12::EL… MA19… HOXD1… DRVCGGAA… 1.10e-15      1.18
13 585        95 LR_open   HOXB2::ELK1 MA19… HOXB2… RCCGGAAG… 6.31e- 8      1.04
# ℹ 1 more variable: `TP%` <dbl>

ATF3

# motifs_Atf3 = query(query(MotifDb, 'Hsapiens'), 'ATF3')
    # Atf3_motif <- motifs_Atf3$`Hsapiens-jaspar2022-ATF3-MA0605.2`
# #     # #
# # #
# Atf3_pwm = PWMatrix(
#     ID = 'Atf3',
#     profileMatrix = Atf3_motif)
# Atf3_test = lapply(unlist(seq_all_cd_200) , FUN=searchSeq, x=Atf3_pwm, min.score="80%", strand="*")
# # 
# 
# Atf3_storage <- map_dfr(Atf3_test, ~as.data.frame(.x), .id="id")

# saveRDS(Atf3_storage, "data/Final_four_data/Atf3_motif_8group.RDS")
Atf3_motif_8group <- readRDS("data/Final_four_data/Atf3_motif_8group.RDS")
Atf3_motif_8group %>%
  mutate(id= gsub("_resized","",id)) %>% 
  # dplyr::filter(id =="EAR_open"|id == "NR"|id=="EAR_close") %>%
  dplyr::filter(relScore>0.90) %>%
  mutate(position=start-500) %>% 
  ggplot(.,aes(position, color = id))+
  geom_density(trim = FALSE,size=1.5) +
  theme_bw() +
  scale_color_manual(values=mrc_palette)+
  ggtitle("Atf3 motif")

spec_dataframe %>% 
  dplyr::filter(stringr::str_detect( motif_name,"Atf^*")) %>% 
  dplyr::select(RANK ,CLUSTER,mrc,motif_name,ID:CONSENSUS,EVALUE,ENR_RATIO,`TP%`)

# A tibble: 7 × 10
  RANK  CLUSTER mrc       motif_name ID     ALT_ID CONSENSUS    EVALUE ENR_RATIO
  <chr>   <dbl> <chr>     <chr>      <chr>  <chr>  <chr>         <dbl>     <dbl>
1 4           1 EAR_close Atf3       1-BVT… STREM… BVTGASTC… 1.97e-  5      1.46
2 17          1 EAR_close Atf3       MA198… Atf3   NRTGACTC… 6.54e- 74      1.59
3 24          2 ESR_open  Atf3       MA198… Atf3   NRTGACTC… 2.64e- 81      2.76
4 326        92 ESR_close Atf3       CAGGC… MEME-6 CAGGCRTG… 5.7 e-  3     NA   
5 18          1 ESR_OC    Atf3       MA198… Atf3   NRTGACTC… 7.30e-305     NA   
6 16          1 LR_open   Atf3       MA198… Atf3   NRTGACTC… 1.88e-305      2.73
7 507         4 LR_open   Atf1       MA060… Atf1   RTGACGTA  5.05e- 17      1.03
# ℹ 1 more variable: `TP%` <dbl>

TP53

# motifs_TP53 = query(query(MotifDb, 'Hsapiens'), 'TP53')
    # TP53_motif <- motifs_TP53$`Hsapiens-jaspar2022-TP53-MA0106.3`


# TP53_pwm = PWMatrix(
# ID = 'TP53',
# profileMatrix = TP53_motif)
# TP53_test = lapply(unlist(seq_all_cd_200) , FUN=searchSeq, x=TP53_pwm, min.score="80%", strand="*")


# TP53_storage <- map_dfr(TP53_test, ~as.data.frame(.x), .id="id")
# 
# saveRDS(TP53_storage, "data/Final_four_data/TP53_motif_8group200cd.RDS")
TP53_motif_8group <- readRDS("data/Final_four_data/TP53_motif_8group200cd.RDS")

TP53_motif_8group %>%
  mutate(id= gsub("_resized","",id)) %>% 
  dplyr::filter(id =="LR_open"|id == "NR"|id=="ESR_open") %>%
  dplyr::filter(relScore>0.80) %>%
  mutate(position=start-200) %>%
  ggplot(.,aes(position, color = id))+
  geom_density(trim = FALSE,size=1.5) +
  theme_bw() +
  scale_color_manual(values=mrc_palette)+
  ggtitle("TP53 motif")

spec_dataframe %>% 
  dplyr::filter(stringr::str_detect( motif_name,"TP^*")) %>% 
  dplyr::select(RANK ,CLUSTER,mrc,motif_name,ID:CONSENSUS,EVALUE,ENR_RATIO,`TP%`)

# A tibble: 9 × 10
  RANK  CLUSTER mrc      motif_name ID      ALT_ID CONSENSUS    EVALUE ENR_RATIO
  <chr>   <dbl> <chr>    <chr>      <chr>   <chr>  <chr>         <dbl>     <dbl>
1 38          3 ESR_open TP73       MA0861… TP73   DRCATGTC… 3.94e- 65      2.69
2 41          1 ESR_open TP53       MA0106… TP53   RACATGYC… 2.28e- 59      1.98
3 50          3 ESR_open TP63       MA0525… TP63   RACATGTY… 3.95e- 35      2.96
4 270        52 ESR_OC   TP53       MA0106… TP53   RACATGYC… 5.51e-103     NA   
5 322        52 ESR_OC   TP73       MA0861… TP73   DRCATGTC… 3.95e- 63     NA   
6 329        52 ESR_OC   TP63       MA0525… TP63   RACATGTY… 7.02e- 59     NA   
7 247        47 LR_open  TP53       MA0106… TP53   RACATGYC… 9.37e-129      1.43
8 283        47 LR_open  TP73       MA0861… TP73   DRCATGTC… 1.30e-110      1.93
9 362        47 LR_open  TP63       MA0525… TP63   RACATGTY… 3.89e- 72      2.21
# ℹ 1 more variable: `TP%` <dbl>

TP73

# motifs_TP73 = query(query(MotifDb, 'Hsapiens'), 'TP73')
    # TP73_motif <- motifs_TP73$`Hsapiens-jaspar2022-TP73-MA0861.1`
# 
# tp73list <- seq_all_cd_200[5:6]
# TP73_pwm = PWMatrix(
# ID = 'TP73',
# profileMatrix = TP73_motif)
# TP73_test = lapply(unlist(seq_all_cd_200) , FUN=searchSeq, x=TP73_pwm, min.score="80%", strand="*")
# 

# TP73_storage_cd <- map_dfr(TP73_test, ~as.data.frame(.x), .id="id")
# TP73_teststorage <- rbind(TP73_storage_cd,TP73_motif_8group)
# saveRDS(TP73_storage_cd, "data/Final_four_data/TP73_motif_8group200_cd.RDS")
TP73_motif_8group <- readRDS("data/Final_four_data/TP73_motif_8group200_cd.RDS")

TP73_motif_8group %>%
  mutate(id= gsub("_resized","",id)) %>% 
  dplyr::filter(id =="LR_open"|id == "NR"|id=="ESR_open") %>%
  # dplyr::filter(relScore>0.80) %>%
  # dplyr::filter(id != "ESR_OC") %>% 
  mutate(position=start-200) %>%
  ggplot(.,aes(position, color = id))+
  geom_density(trim = FALSE,size=1.5) +
  theme_bw() +
  scale_color_manual(values=mrc_palette)+
  ggtitle("TP73 motif")

spec_dataframe %>% 
  dplyr::filter(stringr::str_detect( motif_name,"TP73^*")) %>% 
  dplyr::select(RANK ,CLUSTER,mrc,motif_name,ID:CONSENSUS,EVALUE,ENR_RATIO,`TP%`)

# A tibble: 3 × 10
  RANK  CLUSTER mrc      motif_name ID      ALT_ID CONSENSUS    EVALUE ENR_RATIO
  <chr>   <dbl> <chr>    <chr>      <chr>   <chr>  <chr>         <dbl>     <dbl>
1 38          3 ESR_open TP73       MA0861… TP73   DRCATGTC… 3.94e- 65      2.69
2 322        52 ESR_OC   TP73       MA0861… TP73   DRCATGTC… 3.95e- 63     NA   
3 283        47 LR_open  TP73       MA0861… TP73   DRCATGTC… 1.30e-110      1.93
# ℹ 1 more variable: `TP%` <dbl>

JUNB

# motifs_JUNB = query(query(MotifDb, 'Hsapiens'), 'JUNB')
#     JUNB_motif <- motifs_JUNB$`Hsapiens-jaspar2022-JUNB-MA0490.2`  
# # JUNBlist <- seq_all_cd_200[5:6]
# JUNB_pwm = PWMatrix(
# ID = 'JUNB',
# profileMatrix = JUNB_motif)
# JUNB_test = lapply(unlist(seq_all_cd_200) , FUN=searchSeq, x=JUNB_pwm, min.score="80%", strand="*")
# # 

# JUNB_storage_cd <- map_dfr(JUNB_test, ~as.data.frame(.x), .id="id")
# 
# saveRDS(JUNB_storage_cd, "data/Final_four_data/JUNB_motif_8group200_cd.RDS")
JUNB_motif_8group <- readRDS("data/Final_four_data/JUNB_motif_8group200_cd.RDS")

JUNB_motif_8group %>%
  mutate(id= gsub("_resized","",id)) %>% 
   dplyr::filter(id =="LR_open"|id == "NR"|id=="ESR_open") %>%
  # dplyr::filter(relScore>0.90) %>%
  # dplyr::filter(id != "ESR_OC") %>% 
  mutate(position=start-200) %>%
  ggplot(.,aes(position, color = id))+
  geom_density(trim = FALSE,size=1.5) +
  theme_bw() +
  scale_color_manual(values=mrc_palette)+
  ggtitle("JUNB motif")

spec_dataframe %>% 
  dplyr::filter(stringr::str_detect( motif_name,"JUNB^*")) %>% 
  dplyr::select(RANK ,CLUSTER,mrc,motif_name,ID:CONSENSUS,EVALUE,ENR_RATIO,`TP%`)

# A tibble: 37 × 10
   RANK  CLUSTER mrc       motif_name  ID    ALT_ID CONSENSUS   EVALUE ENR_RATIO
   <chr>   <dbl> <chr>     <chr>       <chr> <chr>  <chr>        <dbl>     <dbl>
 1 3           1 EAR_close JUNB        MA04… JUNB   NNATGACT… 4.68e-84      1.41
 2 15          1 EAR_close FOSL2::JUNB MA11… FOSL2… KRTGASTC… 5.70e-77      1.49
 3 18          1 EAR_close FOS::JUNB   MA11… FOS::… KATGASTC… 5.69e-71      1.35
 4 23          1 EAR_close FOSL1::JUNB MA11… FOSL1… NDRTGACT… 3.36e-68      1.32
 5 26          1 EAR_close FOSB::JUNB  MA11… FOSB:… KRTGASTC… 6.01e-64      1.26
 6 30          1 EAR_close JUN::JUNB   MA11… JUN::… KATGACKC… 2.72e-56      1.33
 7 69          6 EAR_close FOSL2::JUNB MA11… FOSL2… DATGACGT… 3.85e-22      1.1 
 8 191         6 EAR_close JUN::JUNB   MA11… JUN::… KRTGACGT… 6.53e-12      1.06
 9 233         6 EAR_close FOSB::JUNB  MA11… FOSB:… RTGACGTC… 5.75e-10      1.15
10 6           2 ESR_open  JUNB        MA04… JUNB   NNATGACT… 3.85e-99      2.47
# ℹ 27 more rows
# ℹ 1 more variable: `TP%` <dbl>

MEIS2

# motifs_MEIS2 = query(query(MotifDb, 'Hsapiens'), 'MEIS2')
#       MEIS2_motif <- motifs_MEIS2$`Hsapiens-jaspar2022-MEIS2-MA0774.1`
# # # MEIS2list <- seq_all_cd_200[5:6]
# MEIS2_pwm = PWMatrix(
# ID = 'MEIS2',
# profileMatrix = MEIS2_motif)
# MEIS2_test = lapply(unlist(seq_all_cd_200) , FUN=searchSeq, x=MEIS2_pwm, min.score="80%", strand="*")
# # 

# MEIS2_storage_cd <- map_dfr(MEIS2_test, ~as.data.frame(.x), .id="id")
# 
# saveRDS(MEIS2_storage_cd, "data/Final_four_data/MEIS2_motif_8group200_cd.RDS")
MEIS2_motif_8group <- readRDS("data/Final_four_data/MEIS2_motif_8group200_cd.RDS")

MEIS2_motif_8group %>%
  mutate(id= gsub("_resized","",id)) %>% 
  dplyr::filter(id =="LR_close"|id == "NR"|id=="ESR_close"|id=="EAR_close") %>%
  # dplyr::filter(relScore>0.90) %>%
  # dplyr::filter(id != "ESR_OC") %>% 
  mutate(position=start-200) %>%
  ggplot(.,aes(position, color = id))+
  geom_density(trim = FALSE,size=1.5) +
  theme_bw() +
  scale_color_manual(values=mrc_palette)+
  ggtitle("MEIS2 motif")

spec_dataframe_200 %>% 
  dplyr::filter(stringr::str_detect( motif_name,"MEIS2^*")) %>% 
  dplyr::select(RANK ,CLUSTER,mrc,motif_name,ID:CONSENSUS,EVALUE.x,ENR_RATIO,`TP%`)

# A tibble: 8 × 10
  RANK  CLUSTER mrc       motif_name ID     ALT_ID CONSENSUS  EVALUE.x ENR_RATIO
  <chr>   <dbl> <chr>     <chr>      <chr>  <chr>  <chr>         <dbl>     <dbl>
1 71         11 EAR_close MEIS2      MA164… MEIS2  NNATGATT… 2.42e- 27      1.05
2 190         3 EAR_close MEIS2      MA077… MEIS2  TTGACAGS  2.61e- 14      1.04
3 3           3 ESR_close MEIS2      1-RGC… STREM… RGCTGTCA  2.27e- 20      1.26
4 11          3 ESR_close MEIS2      MA077… MEIS2  TTGACAGS  1.33e- 93      1.24
5 42          1 LR_open   MEIS2      MA164… MEIS2  NNATGATT… 6.78e-305      1.13
6 1           1 LR_close  MEIS2      1-STG… STREM… STGMCAG   1.54e- 12      1.26
7 3           1 LR_close  MEIS2      MA077… MEIS2  TTGACAGS  1.30e-106      1.42
8 68         14 LR_close  MEIS2      MA164… MEIS2  NNATGATT… 2.07e- 28      1.03
# ℹ 1 more variable: `TP%` <dbl>

sessionInfo()

R version 4.4.1 (2024-06-14 ucrt)
Platform: x86_64-w64-mingw32/x64
Running under: Windows 10 x64 (build 19045)

Matrix products: default


locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

time zone: America/Chicago
tzcode source: internal

attached base packages:
[1] grid      stats4    stats     graphics  grDevices utils     datasets 
[8] methods   base     

other attached packages:
 [1] data.table_1.16.0                       
 [2] BSgenome.Hsapiens.UCSC.hg38_1.4.5       
 [3] BSgenome_1.72.0                         
 [4] BiocIO_1.14.0                           
 [5] MotifDb_1.46.0                          
 [6] Biostrings_2.72.1                       
 [7] XVector_0.44.0                          
 [8] TFBSTools_1.42.0                        
 [9] JASPAR2022_0.99.8                       
[10] BiocFileCache_2.12.0                    
[11] dbplyr_2.5.0                            
[12] devtools_2.4.5                          
[13] usethis_3.0.0                           
[14] ggpubr_0.6.0                            
[15] BiocParallel_1.38.0                     
[16] Cormotif_1.50.0                         
[17] affy_1.82.0                             
[18] scales_1.3.0                            
[19] VennDiagram_1.7.3                       
[20] futile.logger_1.4.3                     
[21] gridExtra_2.3                           
[22] ggfortify_0.4.17                        
[23] edgeR_4.2.1                             
[24] limma_3.60.4                            
[25] rtracklayer_1.64.0                      
[26] org.Hs.eg.db_3.19.1                     
[27] TxDb.Hsapiens.UCSC.hg38.knownGene_3.18.0
[28] GenomicFeatures_1.56.0                  
[29] AnnotationDbi_1.66.0                    
[30] Biobase_2.64.0                          
[31] GenomicRanges_1.56.1                    
[32] GenomeInfoDb_1.40.1                     
[33] IRanges_2.38.1                          
[34] S4Vectors_0.42.1                        
[35] BiocGenerics_0.50.0                     
[36] ChIPseeker_1.40.0                       
[37] RColorBrewer_1.1-3                      
[38] broom_1.0.7                             
[39] kableExtra_1.4.0                        
[40] cowplot_1.1.3                           
[41] lubridate_1.9.3                         
[42] forcats_1.0.0                           
[43] stringr_1.5.1                           
[44] dplyr_1.1.4                             
[45] purrr_1.0.2                             
[46] readr_2.1.5                             
[47] tidyr_1.3.1                             
[48] tibble_3.2.1                            
[49] ggplot2_3.5.1                           
[50] tidyverse_2.0.0                         
[51] workflowr_1.7.1                         

loaded via a namespace (and not attached):
  [1] fs_1.6.4                               
  [2] matrixStats_1.4.1                      
  [3] bitops_1.0-8                           
  [4] DirichletMultinomial_1.46.0            
  [5] enrichplot_1.24.4                      
  [6] httr_1.4.7                             
  [7] profvis_0.4.0                          
  [8] tools_4.4.1                            
  [9] backports_1.5.0                        
 [10] utf8_1.2.4                             
 [11] R6_2.5.1                               
 [12] lazyeval_0.2.2                         
 [13] urlchecker_1.0.1                       
 [14] withr_3.0.1                            
 [15] preprocessCore_1.66.0                  
 [16] cli_3.6.3                              
 [17] formatR_1.14                           
 [18] scatterpie_0.2.4                       
 [19] labeling_0.4.3                         
 [20] sass_0.4.9                             
 [21] Rsamtools_2.20.0                       
 [22] systemfonts_1.1.0                      
 [23] yulab.utils_0.1.7                      
 [24] DOSE_3.30.5                            
 [25] svglite_2.1.3                          
 [26] R.utils_2.12.3                         
 [27] sessioninfo_1.2.2                      
 [28] plotrix_3.8-4                          
 [29] rstudioapi_0.16.0                      
 [30] RSQLite_2.3.7                          
 [31] generics_0.1.3                         
 [32] gridGraphics_0.5-1                     
 [33] TxDb.Hsapiens.UCSC.hg19.knownGene_3.2.2
 [34] gtools_3.9.5                           
 [35] car_3.1-3                              
 [36] GO.db_3.19.1                           
 [37] Matrix_1.7-0                           
 [38] fansi_1.0.6                            
 [39] abind_1.4-8                            
 [40] R.methodsS3_1.8.2                      
 [41] lifecycle_1.0.4                        
 [42] whisker_0.4.1                          
 [43] yaml_2.3.10                            
 [44] carData_3.0-5                          
 [45] SummarizedExperiment_1.34.0            
 [46] gplots_3.1.3.1                         
 [47] qvalue_2.36.0                          
 [48] SparseArray_1.4.8                      
 [49] blob_1.2.4                             
 [50] promises_1.3.0                         
 [51] pwalign_1.0.0                          
 [52] crayon_1.5.3                           
 [53] miniUI_0.1.1.1                         
 [54] lattice_0.22-6                         
 [55] annotate_1.82.0                        
 [56] KEGGREST_1.44.1                        
 [57] pillar_1.9.0                           
 [58] knitr_1.48                             
 [59] fgsea_1.30.0                           
 [60] rjson_0.2.23                           
 [61] boot_1.3-31                            
 [62] codetools_0.2-20                       
 [63] fastmatch_1.1-4                        
 [64] glue_1.8.0                             
 [65] getPass_0.2-4                          
 [66] ggfun_0.1.6                            
 [67] remotes_2.5.0                          
 [68] vctrs_0.6.5                            
 [69] png_0.1-8                              
 [70] treeio_1.28.0                          
 [71] poweRlaw_0.80.0                        
 [72] gtable_0.3.5                           
 [73] cachem_1.1.0                           
 [74] xfun_0.47                              
 [75] mime_0.12                              
 [76] S4Arrays_1.4.1                         
 [77] tidygraph_1.3.1                        
 [78] pracma_2.4.4                           
 [79] statmod_1.5.0                          
 [80] ellipsis_0.3.2                         
 [81] nlme_3.1-166                           
 [82] ggtree_3.12.0                          
 [83] bit64_4.5.2                            
 [84] filelock_1.0.3                         
 [85] rprojroot_2.0.4                        
 [86] bslib_0.8.0                            
 [87] affyio_1.74.0                          
 [88] KernSmooth_2.23-24                     
 [89] splitstackshape_1.4.8                  
 [90] seqLogo_1.70.0                         
 [91] colorspace_2.1-1                       
 [92] DBI_1.2.3                              
 [93] tidyselect_1.2.1                       
 [94] processx_3.8.4                         
 [95] bit_4.5.0                              
 [96] compiler_4.4.1                         
 [97] curl_5.2.3                             
 [98] git2r_0.33.0                           
 [99] httr2_1.0.5                            
[100] xml2_1.3.6                             
[101] DelayedArray_0.30.1                    
[102] shadowtext_0.1.4                       
[103] caTools_1.18.3                         
[104] callr_3.7.6                            
[105] rappdirs_0.3.3                         
[106] digest_0.6.37                          
[107] rmarkdown_2.28                         
[108] htmltools_0.5.8.1                      
[109] pkgconfig_2.0.3                        
[110] MatrixGenerics_1.16.0                  
[111] highr_0.11                             
[112] fastmap_1.2.0                          
[113] htmlwidgets_1.6.4                      
[114] rlang_1.1.4                            
[115] UCSC.utils_1.0.0                       
[116] shiny_1.9.1                            
[117] farver_2.1.2                           
[118] jquerylib_0.1.4                        
[119] jsonlite_1.8.9                         
[120] GOSemSim_2.30.2                        
[121] R.oo_1.26.0                            
[122] RCurl_1.98-1.16                        
[123] magrittr_2.0.3                         
[124] Formula_1.2-5                          
[125] GenomeInfoDbData_1.2.12                
[126] ggplotify_0.1.2                        
[127] patchwork_1.3.0                        
[128] munsell_0.5.1                          
[129] Rcpp_1.0.13                            
[130] ape_5.8                                
[131] viridis_0.6.5                          
[132] stringi_1.8.4                          
[133] ggraph_2.2.1                           
[134] zlibbioc_1.50.0                        
[135] MASS_7.3-61                            
[136] pkgbuild_1.4.4                         
[137] plyr_1.8.9                             
[138] parallel_4.4.1                         
[139] ggrepel_0.9.6                          
[140] CNEr_1.40.0                            
[141] graphlayouts_1.2.0                     
[142] splines_4.4.1                          
[143] hms_1.1.3                              
[144] locfit_1.5-9.10                        
[145] ps_1.8.0                               
[146] igraph_2.0.3                           
[147] ggsignif_0.6.4                         
[148] pkgload_1.4.0                          
[149] reshape2_1.4.4                         
[150] TFMPvalue_0.0.9                        
[151] futile.options_1.0.1                   
[152] XML_3.99-0.17                          
[153] evaluate_1.0.0                         
[154] lambda.r_1.2.4                         
[155] BiocManager_1.30.25                    
[156] tzdb_0.4.0                             
[157] tweenr_2.0.3                           
[158] httpuv_1.6.15                          
[159] polyclip_1.10-7                        
[160] ggforce_0.4.2                          
[161] xtable_1.8-4                           
[162] restfulr_0.0.15                        
[163] tidytree_0.4.6                         
[164] rstatix_0.7.2                          
[165] later_1.3.2                            
[166] viridisLite_0.4.2                      
[167] aplot_0.2.3                            
[168] memoise_2.0.1                          
[169] GenomicAlignments_1.40.0               
[170] timechange_0.3.0

Jaspar_enrichment

ERM

2024-10-09

packages

Data loading

Enrichment all peaks to NR peaks

EAR lists

ESR lists

LR lists

All enriched motifs found

data plots from full sequences

data plots from 200 bp sequences

EAR 200 bp barplots

EAR_close

EAR_close 200bp

ESR

ESR_open

ESR_close

ESR_OC

ESR_opcl {C}

LR

LR_open

LR_close

motif and peak section (incomplete)

NRF1

BACH2

ZNF384

ELK3

ATF3

TP53

TP73

JUNB

MEIS2