Last updated: 2023-04-20

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Knit directory: Cardiotoxicity/

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File	Version	Author	Date	Message
Rmd	9d976da	reneeisnowhere	2023-04-20	update broken image
html	60af208	reneeisnowhere	2023-04-20	Build site.
Rmd	2b12884	reneeisnowhere	2023-04-20	pheatmap color
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Rmd	be18119	reneeisnowhere	2023-04-20	updated adj pvalue
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Rmd	457bc7e	reneeisnowhere	2023-04-17	updated GO analysis
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Rmd	4e52216	reneeisnowhere	2023-03-31	End of week updates

GO Analysis

I have created several files from the RNA analysis that contain the significant genes(determined by adj.P.val < 0.05) from each Time and Condition. The names of the files are in the following format: ‘sigV’+Drug(2 letters)+time.

example: ‘sigVDA3.txt’ means this file contains the significant DE genes from the Daunorubicin 3 hour compared to Vehicle Control 3 hour analysis

<environment: R_GlobalEnv>

The analysis is based on all genes that passed the rowMeans>0 from the previous page which are about 14084 genes expressed in my RNA-seq data link

All analysis is completed with an adjusted p value of 0.05 This is updated from the 0.1 value I had been using.

2023-04-19 RM

Knowels, et al. mentioned a relationship between transcriptional change level indicating cardiotoxicity. This may be an observation that supports that claim as well. ## Daunorubicin

This is analysis on the significantly differentially expressed genes for Daunorubicin by 3 and 24 hours.

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	217	1915	1.99e-34
GO:BP	GO:0006366	transcription by RNA polymerase II	222	1991	1.99e-34
GO:BP	GO:0006351	DNA-templated transcription	258	2683	1.58e-31
GO:BP	GO:0097659	nucleic acid-templated transcription	258	2684	1.58e-31
GO:BP	GO:1903506	regulation of nucleic acid-templated transcription	251	2581	6.94e-31
GO:BP	GO:0006355	regulation of DNA-templated transcription	251	2579	6.94e-31
GO:BP	GO:0032774	RNA biosynthetic process	258	2714	6.94e-31
GO:BP	GO:0051252	regulation of RNA metabolic process	267	2849	7.48e-31
GO:BP	GO:2001141	regulation of RNA biosynthetic process	251	2598	1.71e-30
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	280	3105	4.11e-30
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	263	3015	1.45e-26
GO:BP	GO:0031326	regulation of cellular biosynthetic process	264	3123	4.18e-24
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	261	3083	8.83e-24
GO:BP	GO:0009889	regulation of biosynthetic process	265	3174	1.97e-23
GO:BP	GO:0018130	heterocycle biosynthetic process	263	3148	2.58e-23
GO:BP	GO:0019438	aromatic compound biosynthetic process	262	3149	9.91e-23
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	265	3253	1.60e-21
GO:BP	GO:0009059	macromolecule biosynthetic process	279	3730	6.11e-19
GO:BP	GO:0031323	regulation of cellular metabolic process	310	4305	1.87e-18
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	306	4330	4.67e-16
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	273	3758	7.50e-16
GO:BP	GO:0080090	regulation of primary metabolic process	311	4440	8.59e-16
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	90	735	1.46e-14
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	104	1009	3.12e-12
GO:BP	GO:1903507	negative regulation of nucleic acid-templated transcription	104	1011	3.31e-12
GO:BP	GO:0051253	negative regulation of RNA metabolic process	110	1115	5.72e-12
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	104	1020	6.16e-12
GO:BP	GO:0044249	cellular biosynthetic process	292	4465	4.95e-11
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	113	1215	1.07e-10
GO:BP	GO:0010468	regulation of gene expression	279	3583	2.05e-10
GO:BP	GO:1901576	organic substance biosynthetic process	293	4537	2.29e-10
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	109	1206	7.83e-10
GO:BP	GO:0009058	biosynthetic process	304	4595	1.41e-09
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	109	1249	7.68e-09
GO:BP	GO:0051254	positive regulation of RNA metabolic process	121	1431	1.41e-08
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	114	1304	1.71e-08
GO:BP	GO:1903508	positive regulation of nucleic acid-templated transcription	114	1304	1.71e-08
GO:BP	GO:0009890	negative regulation of biosynthetic process	109	1273	2.14e-08
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	114	1311	2.14e-08
GO:BP	GO:0031324	negative regulation of cellular metabolic process	136	1780	7.22e-08
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	123	1499	3.42e-07
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	126	1600	3.63e-07
GO:BP	GO:0060255	regulation of macromolecule metabolic process	225	4640	5.26e-07
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	126	1571	1.17e-06
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	72	925	2.18e-06
GO:BP	GO:0009891	positive regulation of biosynthetic process	126	1598	3.59e-06
GO:BP	GO:0019222	regulation of metabolic process	228	5039	5.48e-06
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	134	1866	1.59e-05
GO:BP	GO:0031325	positive regulation of cellular metabolic process	118	2373	9.70e-05
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	163	2425	1.54e-04
GO:BP	GO:0060411	cardiac septum morphogenesis	11	67	2.82e-04
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	21	229	3.51e-04
GO:BP	GO:0003281	ventricular septum development	11	69	4.15e-04
GO:BP	GO:0140467	integrated stress response signaling	6	34	4.85e-04
GO:BP	GO:0003007	heart morphogenesis	19	212	8.67e-04
GO:BP	GO:0030510	regulation of BMP signaling pathway	5	84	1.73e-03
GO:BP	GO:0019827	stem cell population maintenance	12	150	2.02e-03
GO:BP	GO:0098727	maintenance of cell number	12	152	2.48e-03
GO:BP	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	13	126	2.85e-03
GO:BP	GO:0003279	cardiac septum development	12	101	2.99e-03
GO:BP	GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	13	127	3.46e-03
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	171	2648	4.04e-03
GO:BP	GO:0002320	lymphoid progenitor cell differentiation	5	17	4.37e-03
GO:BP	GO:0018076	N-terminal peptidyl-lysine acetylation	3	4	4.49e-03
GO:BP	GO:0003181	atrioventricular valve morphogenesis	5	24	4.94e-03
GO:BP	GO:0003162	atrioventricular node development	3	8	5.55e-03
GO:BP	GO:0003151	outflow tract morphogenesis	9	66	5.81e-03
GO:BP	GO:0060840	artery development	11	82	6.07e-03
GO:BP	GO:0030853	negative regulation of granulocyte differentiation	2	6	6.11e-03
GO:BP	GO:0006473	protein acetylation	15	208	7.40e-03
GO:BP	GO:0021915	neural tube development	16	146	7.42e-03
GO:BP	GO:0060412	ventricular septum morphogenesis	7	40	7.72e-03
GO:BP	GO:0003171	atrioventricular valve development	5	26	7.99e-03
GO:BP	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	12	99	8.33e-03
GO:BP	GO:0043009	chordate embryonic development	41	531	8.33e-03
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	22	301	9.12e-03
GO:BP	GO:0030509	BMP signaling pathway	5	123	9.12e-03
GO:BP	GO:0007179	transforming growth factor beta receptor signaling pathway	15	177	9.29e-03
GO:BP	GO:0045659	negative regulation of neutrophil differentiation	1	2	9.29e-03
GO:BP	GO:0045645	positive regulation of eosinophil differentiation	1	1	9.29e-03
GO:BP	GO:0045643	regulation of eosinophil differentiation	1	1	9.29e-03
GO:BP	GO:0003183	mitral valve morphogenesis	3	10	1.02e-02
GO:BP	GO:0002244	hematopoietic progenitor cell differentiation	11	109	1.04e-02
GO:BP	GO:0071772	response to BMP	5	131	1.13e-02
GO:BP	GO:0060430	lung saccule development	2	7	1.13e-02
GO:BP	GO:0071773	cellular response to BMP stimulus	5	131	1.13e-02
GO:BP	GO:0090425	acinar cell differentiation	3	5	1.14e-02
GO:BP	GO:1902893	regulation of miRNA transcription	5	51	1.19e-02
GO:BP	GO:0010944	negative regulation of transcription by competitive promoter binding	2	8	1.19e-02
GO:BP	GO:0009893	positive regulation of metabolic process	122	2884	1.19e-02
GO:BP	GO:0045658	regulation of neutrophil differentiation	1	2	1.19e-02
GO:BP	GO:1902459	positive regulation of stem cell population maintenance	8	44	1.19e-02
GO:BP	GO:0061614	miRNA transcription	5	52	1.19e-02
GO:BP	GO:0007507	heart development	40	502	1.19e-02
GO:BP	GO:0001841	neural tube formation	10	101	1.19e-02
GO:BP	GO:0003174	mitral valve development	3	11	1.19e-02
GO:BP	GO:0009792	embryo development ending in birth or egg hatching	41	548	1.27e-02
GO:BP	GO:0090304	nucleic acid metabolic process	14	4047	1.35e-02
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	19	263	1.35e-02
GO:BP	GO:0018394	peptidyl-lysine acetylation	13	180	1.35e-02
GO:BP	GO:0001657	ureteric bud development	4	75	1.36e-02
GO:BP	GO:0016070	RNA metabolic process	102	3593	1.36e-02
GO:BP	GO:2001020	regulation of response to DNA damage stimulus	25	292	1.36e-02
GO:BP	GO:0072163	mesonephric epithelium development	4	76	1.36e-02
GO:BP	GO:0036499	PERK-mediated unfolded protein response	4	17	1.36e-02
GO:BP	GO:0072164	mesonephric tubule development	4	76	1.36e-02
GO:BP	GO:0048738	cardiac muscle tissue development	18	198	1.48e-02
GO:BP	GO:0045927	positive regulation of growth	5	200	1.53e-02
GO:BP	GO:0060419	heart growth	10	72	1.53e-02
GO:BP	GO:0001823	mesonephros development	4	77	1.53e-02
GO:BP	GO:0071559	response to transforming growth factor beta	17	224	1.56e-02
GO:BP	GO:0030852	regulation of granulocyte differentiation	2	11	1.60e-02
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	8	79	1.63e-02
GO:BP	GO:0030222	eosinophil differentiation	1	2	1.63e-02
GO:BP	GO:0002763	positive regulation of myeloid leukocyte differentiation	2	34	1.63e-02
GO:BP	GO:0014706	striated muscle tissue development	20	210	1.70e-02
GO:BP	GO:0003179	heart valve morphogenesis	5	50	1.72e-02
GO:BP	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	2	12	1.80e-02
GO:BP	GO:0003310	pancreatic A cell differentiation	2	2	1.84e-02
GO:BP	GO:0030514	negative regulation of BMP signaling pathway	3	45	1.85e-02
GO:BP	GO:2000628	regulation of miRNA metabolic process	5	62	1.88e-02
GO:BP	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	2	4	1.92e-02
GO:BP	GO:0034616	response to laminar fluid shear stress	3	14	1.92e-02
GO:BP	GO:0002328	pro-B cell differentiation	3	10	2.07e-02
GO:BP	GO:0003148	outflow tract septum morphogenesis	3	23	2.13e-02
GO:BP	GO:0003206	cardiac chamber morphogenesis	7	109	2.18e-02
GO:BP	GO:0048639	positive regulation of developmental growth	4	125	2.19e-02
GO:BP	GO:0014020	primary neural tube formation	9	94	2.19e-02
GO:BP	GO:0030854	positive regulation of granulocyte differentiation	1	5	2.31e-02
GO:BP	GO:0043543	protein acylation	15	246	2.39e-02
GO:BP	GO:0055017	cardiac muscle tissue growth	9	65	2.39e-02
GO:BP	GO:0048844	artery morphogenesis	8	57	2.41e-02
GO:BP	GO:2000736	regulation of stem cell differentiation	10	74	2.44e-02
GO:BP	GO:0051890	regulation of cardioblast differentiation	3	7	2.44e-02
GO:BP	GO:1900034	regulation of cellular response to heat	4	16	2.44e-02
GO:BP	GO:0003231	cardiac ventricle development	11	114	2.52e-02
GO:BP	GO:0060420	regulation of heart growth	8	50	2.52e-02
GO:BP	GO:0045445	myoblast differentiation	12	89	2.60e-02
GO:BP	GO:0030223	neutrophil differentiation	1	8	2.68e-02
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	14	4503	2.69e-02
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	16	219	2.71e-02
GO:BP	GO:0035910	ascending aorta morphogenesis	2	4	2.71e-02
GO:BP	GO:0010665	regulation of cardiac muscle cell apoptotic process	4	34	2.71e-02
GO:BP	GO:0048538	thymus development	6	35	2.85e-02
GO:BP	GO:2000036	regulation of stem cell population maintenance	6	62	2.85e-02
GO:BP	GO:0043627	response to estrogen	3	51	2.85e-02
GO:BP	GO:0070848	response to growth factor	32	567	2.85e-02
GO:BP	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress	3	10	2.90e-02
GO:BP	GO:0003170	heart valve development	5	57	2.93e-02
GO:BP	GO:0045597	positive regulation of cell differentiation	4	619	2.93e-02
GO:BP	GO:0003215	cardiac right ventricle morphogenesis	4	17	2.93e-02
GO:BP	GO:1902894	negative regulation of miRNA transcription	2	17	2.99e-02
GO:BP	GO:0060395	SMAD protein signal transduction	5	65	3.01e-02
GO:BP	GO:1904290	negative regulation of mitotic DNA damage checkpoint	1	1	3.11e-02
GO:BP	GO:0035264	multicellular organism growth	12	121	3.11e-02
GO:BP	GO:0001838	embryonic epithelial tube formation	10	116	3.11e-02
GO:BP	GO:0060038	cardiac muscle cell proliferation	7	44	3.14e-02
GO:BP	GO:0010660	regulation of muscle cell apoptotic process	5	57	3.14e-02
GO:BP	GO:0035904	aorta development	7	49	3.14e-02
GO:BP	GO:0046483	heterocycle metabolic process	14	4616	3.14e-02
GO:BP	GO:2000629	negative regulation of miRNA metabolic process	2	18	3.14e-02
GO:BP	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	1	7	3.14e-02
GO:BP	GO:0010659	cardiac muscle cell apoptotic process	4	36	3.14e-02
GO:BP	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	4	39	3.14e-02
GO:BP	GO:0010662	regulation of striated muscle cell apoptotic process	4	37	3.14e-02
GO:BP	GO:0055025	positive regulation of cardiac muscle tissue development	1	2	3.14e-02
GO:BP	GO:0010586	miRNA metabolic process	5	76	3.23e-02
GO:BP	GO:0006725	cellular aromatic compound metabolic process	14	4646	3.29e-02
GO:BP	GO:0045639	positive regulation of myeloid cell differentiation	2	67	3.29e-02
GO:BP	GO:0019935	cyclic-nucleotide-mediated signaling	2	55	3.30e-02
GO:BP	GO:0080135	regulation of cellular response to stress	42	631	3.32e-02
GO:BP	GO:1903674	regulation of cap-dependent translational initiation	1	1	3.43e-02
GO:BP	GO:1903676	positive regulation of cap-dependent translational initiation	1	1	3.43e-02
GO:BP	GO:0045651	positive regulation of macrophage differentiation	1	12	3.43e-02
GO:BP	GO:0060043	regulation of cardiac muscle cell proliferation	6	32	3.44e-02
GO:BP	GO:0032526	response to retinoic acid	4	85	3.44e-02
GO:BP	GO:1901532	regulation of hematopoietic progenitor cell differentiation	5	34	3.48e-02
GO:BP	GO:0072073	kidney epithelium development	4	112	3.48e-02
GO:BP	GO:0002761	regulation of myeloid leukocyte differentiation	3	77	3.48e-02
GO:BP	GO:0003289	atrial septum primum morphogenesis	2	5	3.52e-02
GO:BP	GO:0003284	septum primum development	2	5	3.52e-02
GO:BP	GO:0035905	ascending aorta development	2	5	3.52e-02
GO:BP	GO:0010657	muscle cell apoptotic process	5	60	3.58e-02
GO:BP	GO:0010658	striated muscle cell apoptotic process	4	39	3.73e-02
GO:BP	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	3	18	3.78e-02
GO:BP	GO:0042789	mRNA transcription by RNA polymerase II	5	42	3.78e-02
GO:BP	GO:0032909	regulation of transforming growth factor beta2 production	2	9	3.80e-02
GO:BP	GO:0032906	transforming growth factor beta2 production	2	9	3.80e-02
GO:BP	GO:0034405	response to fluid shear stress	5	31	3.80e-02
GO:BP	GO:0045661	regulation of myoblast differentiation	9	60	3.87e-02
GO:BP	GO:0048636	positive regulation of muscle organ development	1	3	4.05e-02
GO:BP	GO:0016573	histone acetylation	11	165	4.05e-02
GO:BP	GO:0045844	positive regulation of striated muscle tissue development	1	3	4.05e-02
GO:BP	GO:0035909	aorta morphogenesis	5	25	4.06e-02
GO:BP	GO:0010720	positive regulation of cell development	3	316	4.06e-02
GO:BP	GO:0003159	morphogenesis of an endothelium	4	14	4.06e-02
GO:BP	GO:0001843	neural tube closure	8	90	4.06e-02
GO:BP	GO:0045622	regulation of T-helper cell differentiation	3	20	4.06e-02
GO:BP	GO:2000320	negative regulation of T-helper 17 cell differentiation	2	6	4.06e-02
GO:BP	GO:0045603	positive regulation of endothelial cell differentiation	1	8	4.06e-02
GO:BP	GO:0061154	endothelial tube morphogenesis	4	14	4.06e-02
GO:BP	GO:0061008	hepaticobiliary system development	13	109	4.06e-02
GO:BP	GO:0055021	regulation of cardiac muscle tissue growth	7	45	4.06e-02
GO:BP	GO:1901360	organic cyclic compound metabolic process	14	4790	4.06e-02
GO:BP	GO:0030513	positive regulation of BMP signaling pathway	5	34	4.06e-02
GO:BP	GO:0071363	cellular response to growth factor stimulus	30	547	4.06e-02
GO:BP	GO:0072175	epithelial tube formation	12	127	4.06e-02
GO:BP	GO:0008285	negative regulation of cell population proliferation	8	510	4.08e-02
GO:BP	GO:1902106	negative regulation of leukocyte differentiation	3	63	4.08e-02
GO:BP	GO:0006984	ER-nucleus signaling pathway	5	46	4.08e-02
GO:BP	GO:0043620	regulation of DNA-templated transcription in response to stress	4	44	4.08e-02
GO:BP	GO:0060010	Sertoli cell fate commitment	1	1	4.08e-02
GO:BP	GO:0033484	cellular nitric oxide homeostasis	1	3	4.08e-02
GO:BP	GO:0045649	regulation of macrophage differentiation	1	17	4.08e-02
GO:BP	GO:0002067	glandular epithelial cell differentiation	3	49	4.08e-02
GO:BP	GO:1903846	positive regulation of cellular response to transforming growth factor beta stimulus	5	29	4.08e-02
GO:BP	GO:0060606	tube closure	8	91	4.08e-02
GO:BP	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	5	29	4.08e-02
GO:BP	GO:0061626	pharyngeal arch artery morphogenesis	2	10	4.08e-02
GO:BP	GO:0051891	positive regulation of cardioblast differentiation	2	6	4.11e-02
GO:BP	GO:2000121	regulation of removal of superoxide radicals	2	6	4.20e-02
GO:BP	GO:0010656	negative regulation of muscle cell apoptotic process	6	36	4.22e-02
GO:BP	GO:1903707	negative regulation of hemopoiesis	3	67	4.26e-02
GO:BP	GO:0003205	cardiac chamber development	4	149	4.26e-02
GO:BP	GO:0001568	blood vessel development	33	534	4.26e-02
GO:BP	GO:0014912	negative regulation of smooth muscle cell migration	1	24	4.26e-02
GO:BP	GO:0018393	internal peptidyl-lysine acetylation	11	169	4.26e-02
GO:BP	GO:2000317	negative regulation of T-helper 17 type immune response	2	7	4.26e-02
GO:BP	GO:0046620	regulation of organ growth	9	70	4.29e-02
GO:BP	GO:0060487	lung epithelial cell differentiation	2	18	4.29e-02
GO:BP	GO:0060479	lung cell differentiation	2	18	4.29e-02
GO:BP	GO:0072739	response to anisomycin	2	4	4.29e-02
GO:BP	GO:0035019	somatic stem cell population maintenance	7	50	4.29e-02
GO:BP	GO:0033137	negative regulation of peptidyl-serine phosphorylation	2	26	4.29e-02
GO:BP	GO:0030851	granulocyte differentiation	2	26	4.36e-02
GO:BP	GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway	1	15	4.41e-02
GO:BP	GO:0010002	cardioblast differentiation	4	17	4.41e-02
GO:BP	GO:0006475	internal protein amino acid acetylation	11	171	4.41e-02
GO:BP	GO:0035265	organ growth	13	129	4.43e-02
GO:BP	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	3	22	4.43e-02
GO:BP	GO:0034641	cellular nitrogen compound metabolic process	14	4991	4.44e-02
GO:BP	GO:0007613	memory	2	90	4.45e-02
GO:BP	GO:1900246	positive regulation of RIG-I signaling pathway	3	7	4.52e-02
GO:BP	GO:0071300	cellular response to retinoic acid	4	49	4.62e-02
GO:BP	GO:1903043	positive regulation of chondrocyte hypertrophy	1	1	4.70e-02
GO:BP	GO:1903041	regulation of chondrocyte hypertrophy	1	1	4.70e-02
GO:BP	GO:0060575	intestinal epithelial cell differentiation	3	17	4.70e-02
GO:BP	GO:0031018	endocrine pancreas development	4	31	4.73e-02
GO:BP	GO:1904003	negative regulation of sebum secreting cell proliferation	1	1	4.75e-02
GO:BP	GO:0060413	atrial septum morphogenesis	3	15	4.75e-02
GO:BP	GO:0006282	regulation of DNA repair	17	197	4.75e-02
GO:BP	GO:0090288	negative regulation of cellular response to growth factor stimulus	3	81	4.80e-02
GO:BP	GO:0009299	mRNA transcription	5	47	4.86e-02
GO:BP	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	8	90	4.91e-02
GO:BP	GO:0019184	nonribosomal peptide biosynthetic process	3	15	4.91e-02
GO:BP	GO:0045210	FasL biosynthetic process	1	1	4.95e-02
GO:BP	GO:2000737	negative regulation of stem cell differentiation	5	24	4.97e-02
KEGG	KEGG:05168	Herpes simplex virus 1 infection	66	415	5.18e-17

Daunorubicin specific genes at 3 hours

How they may relate to 24 hour genes using GO analysis

3 hours specifically (see venn below too):

All Daun DEGs adj p value < 0.05

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0097659	nucleic acid-templated transcription	137	2684	7.33e-10
GO:BP	GO:0006366	transcription by RNA polymerase II	112	1991	7.33e-10
GO:BP	GO:0006351	DNA-templated transcription	137	2683	7.33e-10
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	108	1915	7.33e-10
GO:BP	GO:0032774	RNA biosynthetic process	137	2714	1.01e-09
GO:BP	GO:1903506	regulation of nucleic acid-templated transcription	132	2581	1.45e-09
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	148	3105	1.45e-09
GO:BP	GO:0006355	regulation of DNA-templated transcription	132	2579	1.45e-09
GO:BP	GO:0051252	regulation of RNA metabolic process	140	2849	1.45e-09
GO:BP	GO:2001141	regulation of RNA biosynthetic process	132	2598	1.94e-09
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	149	3015	1.91e-08
GO:BP	GO:0031326	regulation of cellular biosynthetic process	144	3123	1.78e-07
GO:BP	GO:0009889	regulation of biosynthetic process	145	3174	2.65e-07
GO:BP	GO:0018130	heterocycle biosynthetic process	141	3148	5.35e-07
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	139	3083	5.35e-07
GO:BP	GO:0019438	aromatic compound biosynthetic process	140	3149	1.17e-06
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	143	3253	1.63e-06
GO:BP	GO:0009059	macromolecule biosynthetic process	150	3730	1.24e-05
GO:BP	GO:0031323	regulation of cellular metabolic process	169	4305	1.24e-05
GO:BP	GO:0140467	integrated stress response signaling	4	34	5.91e-04
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	145	3758	5.91e-04
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	43	735	9.74e-04
GO:BP	GO:0080090	regulation of primary metabolic process	166	4440	1.17e-03
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	162	4330	1.46e-03
GO:BP	GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	3	18	2.72e-03
GO:BP	GO:0044249	cellular biosynthetic process	167	4465	3.49e-03
GO:BP	GO:1901576	organic substance biosynthetic process	168	4537	5.88e-03
GO:BP	GO:0034599	cellular response to oxidative stress	6	239	7.97e-03
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	65	1304	7.97e-03
GO:BP	GO:1903508	positive regulation of nucleic acid-templated transcription	65	1304	7.97e-03
GO:BP	GO:2001020	regulation of response to DNA damage stimulus	19	292	7.97e-03
GO:BP	GO:0009058	biosynthetic process	169	4595	7.97e-03
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	65	1311	8.55e-03
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	71	1499	1.00e-02
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	74	1571	1.00e-02
GO:BP	GO:2000121	regulation of removal of superoxide radicals	2	6	1.02e-02
GO:BP	GO:0051253	negative regulation of RNA metabolic process	53	1115	1.02e-02
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	55	1215	1.28e-02
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	49	1009	1.29e-02
GO:BP	GO:1903507	negative regulation of nucleic acid-templated transcription	49	1011	1.31e-02
GO:BP	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	3	39	1.39e-02
GO:BP	GO:0009891	positive regulation of biosynthetic process	71	1598	1.55e-02
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	49	1020	1.57e-02
GO:BP	GO:0062197	cellular response to chemical stress	6	290	1.62e-02
GO:BP	GO:0051254	positive regulation of RNA metabolic process	67	1431	1.77e-02
GO:BP	GO:0036499	PERK-mediated unfolded protein response	3	17	1.77e-02
GO:BP	GO:0043620	regulation of DNA-templated transcription in response to stress	3	44	1.84e-02
GO:BP	GO:2000377	regulation of reactive oxygen species metabolic process	5	107	1.99e-02
GO:BP	GO:0010632	regulation of epithelial cell migration	5	195	2.15e-02
GO:BP	GO:0034614	cellular response to reactive oxygen species	4	121	3.66e-02
GO:BP	GO:0002244	hematopoietic progenitor cell differentiation	4	109	4.11e-02
GO:BP	GO:0010634	positive regulation of epithelial cell migration	4	132	4.22e-02
GO:BP	GO:0006979	response to oxidative stress	6	349	4.73e-02
KEGG	KEGG:05168	Herpes simplex virus 1 infection	35	415	2.97e-07

[1] 351

Interestingly, Over half of the daunorubicin specific genes are in the Daunorucin 24 hour group.

When I look at those 187 genes, I do not see a significant enrichment in GO:BP terms, only the KEGG pathway connection to Herpes simplex virus

###Daunorubicin 24 sigDEG

Looking at the Daunorubicin 24 hour geneset using adj. P value of 0.05, I have enrichment in the terms cell cycle and chromosome segregation.

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0000278	mitotic cell cycle	196	833	1.44e-05
GO:BP	GO:0000070	mitotic sister chromatid segregation	47	193	2.30e-05
GO:BP	GO:0000819	sister chromatid segregation	71	234	2.30e-05
GO:BP	GO:0045930	negative regulation of mitotic cell cycle	77	208	2.30e-05
GO:BP	GO:1903047	mitotic cell cycle process	163	700	8.44e-05
GO:BP	GO:0007059	chromosome segregation	124	378	8.70e-05
GO:BP	GO:0051301	cell division	143	567	8.70e-05

###Daunorubicin 3 v 24 intersection

All 187 3 hour Daun-specific genes are in the 304 genes between the two full lists of daunorubicin sigDEGs for 3 hours and 24 hours. This could possibly support the idea that Daunorubicin’s more toxic effect is related to earlier impacts on cell function. Note the enriched go terms for the 304 genes that they share. I need to see if there is a trend in EP and DX. I do see in Mito 3 hour (looked a little later).

[1] 7115

[1] 187

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	112	1915	7.05e-14
GO:BP	GO:0006366	transcription by RNA polymerase II	113	1991	2.30e-13
GO:BP	GO:1903506	regulation of nucleic acid-templated transcription	126	2581	1.13e-10
GO:BP	GO:0006355	regulation of DNA-templated transcription	126	2579	1.13e-10
GO:BP	GO:0097659	nucleic acid-templated transcription	128	2684	1.23e-10
GO:BP	GO:0051252	regulation of RNA metabolic process	133	2849	1.23e-10
GO:BP	GO:2001141	regulation of RNA biosynthetic process	126	2598	1.23e-10
GO:BP	GO:0006351	DNA-templated transcription	128	2683	1.23e-10
GO:BP	GO:0032774	RNA biosynthetic process	128	2714	2.39e-10
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	101	3015	7.57e-10
GO:BP	GO:0031326	regulation of cellular biosynthetic process	102	3123	3.16e-09
GO:BP	GO:0009889	regulation of biosynthetic process	103	3174	3.16e-09
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	101	3105	5.02e-09
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	52	735	1.23e-08
GO:BP	GO:0018130	heterocycle biosynthetic process	99	3148	6.87e-08
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	97	3083	1.33e-07
GO:BP	GO:0019438	aromatic compound biosynthetic process	98	3149	1.81e-07
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	100	3253	2.18e-07
GO:BP	GO:0009059	macromolecule biosynthetic process	107	3730	4.29e-07
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	106	3758	2.33e-06
GO:BP	GO:1903507	negative regulation of nucleic acid-templated transcription	44	1011	4.37e-06
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	44	1009	4.37e-06
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	44	1020	5.49e-06
GO:BP	GO:0051253	negative regulation of RNA metabolic process	60	1115	5.49e-06
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	119	4330	6.97e-06
GO:BP	GO:0031323	regulation of cellular metabolic process	118	4305	6.97e-06
GO:BP	GO:0080090	regulation of primary metabolic process	121	4440	8.39e-06
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	47	1206	1.69e-05
GO:BP	GO:0044249	cellular biosynthetic process	114	4465	4.04e-05
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	47	1249	4.84e-05
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	46	1215	6.86e-05
GO:BP	GO:0009890	negative regulation of biosynthetic process	47	1273	7.96e-05
GO:BP	GO:1901576	organic substance biosynthetic process	114	4537	9.44e-05
GO:BP	GO:0010468	regulation of gene expression	109	3583	1.30e-04
GO:BP	GO:0009058	biosynthetic process	114	4595	2.14e-04
GO:BP	GO:0031324	negative regulation of cellular metabolic process	58	1780	7.01e-04
GO:BP	GO:0003007	heart morphogenesis	14	212	8.69e-04
GO:BP	GO:0003162	atrioventricular node development	3	8	1.31e-03
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	35	925	1.58e-03
GO:BP	GO:0048738	cardiac muscle tissue development	14	198	1.79e-03
GO:BP	GO:0051254	positive regulation of RNA metabolic process	45	1431	2.89e-03
GO:BP	GO:0014706	striated muscle tissue development	15	210	3.64e-03
GO:BP	GO:0060411	cardiac septum morphogenesis	7	67	3.64e-03
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	61	1304	4.13e-03
GO:BP	GO:1903508	positive regulation of nucleic acid-templated transcription	61	1304	4.13e-03
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	42	1311	4.49e-03
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	48	1571	4.98e-03
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	69	2425	5.07e-03
GO:BP	GO:0031325	positive regulation of cellular metabolic process	68	2373	5.16e-03
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	46	1499	5.40e-03
GO:BP	GO:0009891	positive regulation of biosynthetic process	48	1598	7.49e-03
GO:BP	GO:0051890	regulation of cardioblast differentiation	3	7	9.36e-03
GO:BP	GO:0003310	pancreatic A cell differentiation	2	2	1.18e-02
GO:BP	GO:0060255	regulation of macromolecule metabolic process	123	4640	1.22e-02
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	56	1866	1.34e-02
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	46	1600	1.35e-02
GO:BP	GO:0060412	ventricular septum morphogenesis	5	40	1.41e-02
GO:BP	GO:0055017	cardiac muscle tissue growth	7	65	1.46e-02
GO:BP	GO:1902894	negative regulation of miRNA transcription	2	17	2.11e-02
GO:BP	GO:0003197	endocardial cushion development	5	42	2.25e-02
GO:BP	GO:2000629	negative regulation of miRNA metabolic process	2	18	2.27e-02
GO:BP	GO:0045622	regulation of T-helper cell differentiation	3	20	2.29e-02
GO:BP	GO:0002067	glandular epithelial cell differentiation	3	49	2.43e-02
GO:BP	GO:0003281	ventricular septum development	6	69	2.54e-02
GO:BP	GO:0060575	intestinal epithelial cell differentiation	3	17	2.54e-02
GO:BP	GO:0045927	positive regulation of growth	4	200	2.54e-02
GO:BP	GO:0060419	heart growth	7	72	2.56e-02
GO:BP	GO:0043009	chordate embryonic development	22	531	2.69e-02
GO:BP	GO:0032906	transforming growth factor beta2 production	3	9	2.69e-02
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	6	79	2.69e-02
GO:BP	GO:0032909	regulation of transforming growth factor beta2 production	3	9	2.69e-02
GO:BP	GO:0019184	nonribosomal peptide biosynthetic process	3	15	2.69e-02
GO:BP	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	8	99	2.69e-02
GO:BP	GO:0003279	cardiac septum development	5	101	2.69e-02
GO:BP	GO:0007507	heart development	25	502	2.69e-02
GO:BP	GO:0048645	animal organ formation	7	52	2.69e-02
GO:BP	GO:0060038	cardiac muscle cell proliferation	5	44	2.69e-02
GO:BP	GO:0051891	positive regulation of cardioblast differentiation	2	6	2.78e-02
GO:BP	GO:0035051	cardiocyte differentiation	9	129	2.78e-02
GO:BP	GO:0003151	outflow tract morphogenesis	6	66	2.78e-02
GO:BP	GO:2000121	regulation of removal of superoxide radicals	2	6	2.85e-02
GO:BP	GO:2000320	negative regulation of T-helper 17 cell differentiation	2	6	2.85e-02
GO:BP	GO:0071773	cellular response to BMP stimulus	6	131	3.00e-02
GO:BP	GO:0071772	response to BMP	6	131	3.00e-02
GO:BP	GO:0061626	pharyngeal arch artery morphogenesis	2	10	3.00e-02
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	68	2648	3.17e-02
GO:BP	GO:2000317	negative regulation of T-helper 17 type immune response	2	7	3.18e-02
GO:BP	GO:0009792	embryo development ending in birth or egg hatching	22	548	3.41e-02
GO:BP	GO:0043370	regulation of CD4-positive, alpha-beta T cell differentiation	3	27	3.54e-02
GO:BP	GO:0045603	positive regulation of endothelial cell differentiation	1	8	3.59e-02
GO:BP	GO:0001657	ureteric bud development	3	75	3.90e-02
GO:BP	GO:0072163	mesonephric epithelium development	3	76	3.93e-02
GO:BP	GO:0072164	mesonephric tubule development	3	76	3.93e-02
GO:BP	GO:0019222	regulation of metabolic process	123	5039	3.95e-02
GO:BP	GO:0060010	Sertoli cell fate commitment	1	1	4.11e-02
GO:BP	GO:0001823	mesonephros development	3	77	4.11e-02
GO:BP	GO:0030510	regulation of BMP signaling pathway	3	84	4.11e-02
GO:BP	GO:0014916	regulation of lung blood pressure	2	3	4.11e-02
GO:BP	GO:0009893	positive regulation of metabolic process	71	2884	4.11e-02
GO:BP	GO:0003206	cardiac chamber morphogenesis	5	109	4.11e-02
GO:BP	GO:0019827	stem cell population maintenance	7	150	4.19e-02
GO:BP	GO:0030336	negative regulation of cell migration	9	227	4.25e-02
GO:BP	GO:0033484	cellular nitric oxide homeostasis	1	3	4.25e-02
GO:BP	GO:0060914	heart formation	3	30	4.25e-02
GO:BP	GO:0098727	maintenance of cell number	7	152	4.59e-02
GO:BP	GO:0030307	positive regulation of cell growth	3	136	4.80e-02
GO:BP	GO:1903041	regulation of chondrocyte hypertrophy	1	1	4.80e-02
GO:BP	GO:1903043	positive regulation of chondrocyte hypertrophy	1	1	4.80e-02
GO:BP	GO:0035265	organ growth	9	129	4.80e-02
GO:BP	GO:0003161	cardiac conduction system development	4	34	4.80e-02
GO:BP	GO:0045210	FasL biosynthetic process	1	1	4.80e-02
GO:BP	GO:0048844	artery morphogenesis	5	57	4.82e-02
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	12	229	4.83e-02
GO:BP	GO:0035886	vascular associated smooth muscle cell differentiation	2	27	4.83e-02
GO:BP	GO:1904003	negative regulation of sebum secreting cell proliferation	1	1	4.83e-02
GO:BP	GO:0042093	T-helper cell differentiation	3	38	4.83e-02
GO:BP	GO:0001701	in utero embryonic development	17	342	4.84e-02
GO:BP	GO:0048639	positive regulation of developmental growth	3	125	4.84e-02
GO:BP	GO:0030513	positive regulation of BMP signaling pathway	4	34	4.84e-02
KEGG	KEGG:05168	Herpes simplex virus 1 infection	32	415	1.21e-06

##Doxorubicin 3 hour and 24 hour

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:1904290	negative regulation of mitotic DNA damage checkpoint	1	1	4.04e-02
GO:BP	GO:1900036	positive regulation of cellular response to heat	1	1	4.04e-02
GO:BP	GO:1904289	regulation of mitotic DNA damage checkpoint	1	3	4.04e-02

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0000278	mitotic cell cycle	179	833	6.42e-10
GO:BP	GO:1903047	mitotic cell cycle process	172	700	4.38e-09
GO:BP	GO:0000070	mitotic sister chromatid segregation	66	193	4.38e-09
GO:BP	GO:0000819	sister chromatid segregation	75	234	6.53e-09
GO:BP	GO:0007059	chromosome segregation	103	378	1.54e-08
GO:BP	GO:0045930	negative regulation of mitotic cell cycle	65	208	3.49e-08
GO:BP	GO:0140014	mitotic nuclear division	50	264	3.49e-08
GO:BP	GO:0007093	mitotic cell cycle checkpoint signaling	47	136	5.75e-08
GO:BP	GO:0010564	regulation of cell cycle process	89	620	6.11e-08
GO:BP	GO:0051301	cell division	138	567	1.04e-07
GO:BP	GO:0000075	cell cycle checkpoint signaling	55	180	2.95e-07
GO:BP	GO:0051276	chromosome organization	89	543	1.02e-06
GO:BP	GO:0051726	regulation of cell cycle	135	950	1.98e-06
GO:BP	GO:0000280	nuclear division	93	354	2.14e-06
GO:BP	GO:0022402	cell cycle process	208	1075	2.70e-06
GO:BP	GO:0098813	nuclear chromosome segregation	84	287	2.70e-06
GO:BP	GO:0007051	spindle organization	50	186	4.37e-06
GO:BP	GO:0007052	mitotic spindle organization	29	128	5.58e-06
GO:BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	52	156	5.63e-06
GO:BP	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	11	18	7.10e-06
GO:BP	GO:0007346	regulation of mitotic cell cycle	105	438	7.10e-06
GO:BP	GO:1905818	regulation of chromosome separation	28	69	7.10e-06
GO:BP	GO:1901988	negative regulation of cell cycle phase transition	63	232	7.10e-06
GO:BP	GO:0051225	spindle assembly	31	118	7.10e-06
GO:BP	GO:0008608	attachment of spindle microtubules to kinetochore	19	42	7.74e-06
GO:BP	GO:0048285	organelle fission	97	397	9.81e-06
GO:BP	GO:0051983	regulation of chromosome segregation	39	118	1.12e-05
GO:BP	GO:0007080	mitotic metaphase plate congression	17	55	1.31e-05
GO:BP	GO:0045786	negative regulation of cell cycle	84	334	1.63e-05
GO:BP	GO:0007049	cell cycle	193	1522	1.72e-05
GO:BP	GO:0010948	negative regulation of cell cycle process	69	270	2.11e-05
GO:BP	GO:2001251	negative regulation of chromosome organization	40	90	2.87e-05
GO:BP	GO:0051231	spindle elongation	9	12	2.87e-05
GO:BP	GO:0033047	regulation of mitotic sister chromatid segregation	16	52	2.91e-05
GO:BP	GO:0090068	positive regulation of cell cycle process	56	206	2.91e-05
GO:BP	GO:0051304	chromosome separation	28	74	3.23e-05
GO:BP	GO:0051256	mitotic spindle midzone assembly	8	9	3.36e-05
GO:BP	GO:0006974	cellular response to DNA damage stimulus	151	789	4.69e-05
GO:BP	GO:1903490	positive regulation of mitotic cytokinesis	7	7	5.07e-05
GO:BP	GO:0045839	negative regulation of mitotic nuclear division	22	54	5.22e-05
GO:BP	GO:0030071	regulation of mitotic metaphase/anaphase transition	30	88	5.72e-05
GO:BP	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	20	46	6.12e-05
GO:BP	GO:0051310	metaphase plate congression	18	69	6.14e-05
GO:BP	GO:0006261	DNA-templated DNA replication	60	149	6.14e-05
GO:BP	GO:0007094	mitotic spindle assembly checkpoint signaling	14	44	6.15e-05
GO:BP	GO:0071174	mitotic spindle checkpoint signaling	14	44	6.15e-05
GO:BP	GO:0071173	spindle assembly checkpoint signaling	14	44	6.15e-05
GO:BP	GO:0007088	regulation of mitotic nuclear division	35	100	6.36e-05
GO:BP	GO:0044774	mitotic DNA integrity checkpoint signaling	30	82	6.42e-05
GO:BP	GO:1901991	negative regulation of mitotic cell cycle phase transition	46	163	6.70e-05
GO:BP	GO:0000022	mitotic spindle elongation	8	10	6.85e-05
GO:BP	GO:0010965	regulation of mitotic sister chromatid separation	23	58	7.27e-05
GO:BP	GO:0031577	spindle checkpoint signaling	14	45	7.30e-05
GO:BP	GO:0000226	microtubule cytoskeleton organization	108	552	8.81e-05
GO:BP	GO:1901987	regulation of cell cycle phase transition	52	388	8.96e-05
GO:BP	GO:1902099	regulation of metaphase/anaphase transition of cell cycle	30	89	9.05e-05
GO:BP	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	30	91	9.05e-05
GO:BP	GO:0033046	negative regulation of sister chromatid segregation	20	47	9.17e-05
GO:BP	GO:0033048	negative regulation of mitotic sister chromatid segregation	20	47	9.17e-05
GO:BP	GO:1902100	negative regulation of metaphase/anaphase transition of cell cycle	20	47	9.17e-05
GO:BP	GO:2000816	negative regulation of mitotic sister chromatid separation	20	47	9.17e-05
GO:BP	GO:0033045	regulation of sister chromatid segregation	32	99	1.09e-04
GO:BP	GO:0031570	DNA integrity checkpoint signaling	37	126	1.11e-04
GO:BP	GO:1901990	regulation of mitotic cell cycle phase transition	73	305	1.17e-04
GO:BP	GO:1902412	regulation of mitotic cytokinesis	8	8	1.20e-04
GO:BP	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	10	21	1.21e-04
GO:BP	GO:0051984	positive regulation of chromosome segregation	11	25	1.42e-04
GO:BP	GO:0032465	regulation of cytokinesis	30	79	1.46e-04
GO:BP	GO:0051306	mitotic sister chromatid separation	23	61	1.46e-04
GO:BP	GO:0044784	metaphase/anaphase transition of cell cycle	30	92	1.55e-04
GO:BP	GO:0051985	negative regulation of chromosome segregation	20	48	1.60e-04
GO:BP	GO:1905819	negative regulation of chromosome separation	20	48	1.60e-04
GO:BP	GO:0051783	regulation of nuclear division	25	115	1.60e-04
GO:BP	GO:0044772	mitotic cell cycle phase transition	93	413	1.68e-04
GO:BP	GO:0006281	DNA repair	77	535	1.76e-04
GO:BP	GO:0006541	glutamine metabolic process	4	23	2.23e-04
GO:BP	GO:0006260	DNA replication	116	258	2.32e-04
GO:BP	GO:0051255	spindle midzone assembly	8	12	2.35e-04
GO:BP	GO:0044770	cell cycle phase transition	108	499	2.35e-04
GO:BP	GO:0051784	negative regulation of nuclear division	22	57	2.66e-04
GO:BP	GO:0044773	mitotic DNA damage checkpoint signaling	26	78	2.86e-04
GO:BP	GO:0050000	chromosome localization	19	82	2.87e-04
GO:BP	GO:0090307	mitotic spindle assembly	16	69	2.98e-04
GO:BP	GO:0000077	DNA damage checkpoint signaling	33	118	3.40e-04
GO:BP	GO:0051303	establishment of chromosome localization	18	75	3.52e-04
GO:BP	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore	7	11	3.78e-04
GO:BP	GO:0000281	mitotic cytokinesis	26	81	4.53e-04
GO:BP	GO:1902425	positive regulation of attachment of mitotic spindle microtubules to kinetochore	6	8	4.91e-04
GO:BP	GO:1902423	regulation of attachment of mitotic spindle microtubules to kinetochore	6	8	4.91e-04
GO:BP	GO:0046037	GMP metabolic process	4	24	5.40e-04
GO:BP	GO:0006270	DNA replication initiation	12	35	5.40e-04
GO:BP	GO:0010212	response to ionizing radiation	41	130	6.35e-04
GO:BP	GO:0007017	microtubule-based process	139	756	7.82e-04
GO:BP	GO:0060236	regulation of mitotic spindle organization	8	42	9.20e-04
GO:BP	GO:0006167	AMP biosynthetic process	3	14	9.44e-04
GO:BP	GO:0006177	GMP biosynthetic process	3	14	1.17e-03
GO:BP	GO:0033044	regulation of chromosome organization	72	233	1.69e-03
GO:BP	GO:0090224	regulation of spindle organization	8	45	1.71e-03
GO:BP	GO:1902117	positive regulation of organelle assembly	17	75	1.83e-03
GO:BP	GO:0045787	positive regulation of cell cycle	64	278	1.93e-03
GO:BP	GO:0042770	signal transduction in response to DNA damage	41	173	2.45e-03
GO:BP	GO:0046060	dATP metabolic process	2	3	2.79e-03
GO:BP	GO:0009167	purine ribonucleoside monophosphate metabolic process	4	40	3.31e-03
GO:BP	GO:0051383	kinetochore organization	15	23	3.46e-03
GO:BP	GO:0009126	purine nucleoside monophosphate metabolic process	4	42	3.86e-03
GO:BP	GO:0061640	cytoskeleton-dependent cytokinesis	29	103	3.91e-03
GO:BP	GO:0007098	centrosome cycle	31	126	3.96e-03
GO:BP	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	3	22	3.97e-03
GO:BP	GO:1905820	positive regulation of chromosome separation	12	26	4.56e-03
GO:BP	GO:0071478	cellular response to radiation	36	155	4.60e-03
GO:BP	GO:0000086	G2/M transition of mitotic cell cycle	38	134	4.75e-03
GO:BP	GO:0009127	purine nucleoside monophosphate biosynthetic process	3	24	4.91e-03
GO:BP	GO:0046033	AMP metabolic process	3	22	4.91e-03
GO:BP	GO:0010389	regulation of G2/M transition of mitotic cell cycle	29	92	5.48e-03
GO:BP	GO:0000910	cytokinesis	44	163	5.71e-03
GO:BP	GO:0051302	regulation of cell division	26	144	6.29e-03
GO:BP	GO:0045005	DNA-templated DNA replication maintenance of fidelity	24	50	7.05e-03
GO:BP	GO:0090235	regulation of metaphase plate congression	7	13	7.05e-03
GO:BP	GO:0071479	cellular response to ionizing radiation	23	68	7.06e-03
GO:BP	GO:0030510	regulation of BMP signaling pathway	3	84	7.35e-03
GO:BP	GO:0000731	DNA synthesis involved in DNA repair	11	36	7.68e-03
GO:BP	GO:0044209	AMP salvage	2	5	7.68e-03
GO:BP	GO:0032263	GMP salvage	2	4	7.68e-03
GO:BP	GO:0009262	deoxyribonucleotide metabolic process	23	38	7.86e-03
GO:BP	GO:0019692	deoxyribose phosphate metabolic process	23	38	7.86e-03
GO:BP	GO:0031023	microtubule organizing center organization	27	136	8.40e-03
GO:BP	GO:0104004	cellular response to environmental stimulus	54	264	8.47e-03
GO:BP	GO:0071214	cellular response to abiotic stimulus	54	264	8.47e-03
GO:BP	GO:0044839	cell cycle G2/M phase transition	40	148	8.47e-03
GO:BP	GO:0046601	positive regulation of centriole replication	6	9	9.00e-03
GO:BP	GO:0033554	cellular response to stress	270	1677	9.16e-03
GO:BP	GO:0006979	response to oxidative stress	34	349	1.01e-02
GO:BP	GO:0009411	response to UV	18	137	1.06e-02
GO:BP	GO:0000076	DNA replication checkpoint signaling	10	15	1.12e-02
GO:BP	GO:0042542	response to hydrogen peroxide	15	103	1.17e-02
GO:BP	GO:0000302	response to reactive oxygen species	20	160	1.17e-02
GO:BP	GO:0010332	response to gamma radiation	19	50	1.17e-02
GO:BP	GO:0009394	2’-deoxyribonucleotide metabolic process	22	37	1.18e-02
GO:BP	GO:0009161	ribonucleoside monophosphate metabolic process	4	56	1.18e-02
GO:BP	GO:0044786	cell cycle DNA replication	19	40	1.23e-02
GO:BP	GO:0009064	glutamine family amino acid metabolic process	4	61	1.23e-02
GO:BP	GO:0023019	signal transduction involved in regulation of gene expression	2	14	1.31e-02
GO:BP	GO:0140694	non-membrane-bounded organelle assembly	23	355	1.31e-02
GO:BP	GO:0010639	negative regulation of organelle organization	25	318	1.32e-02
GO:BP	GO:0046053	dAMP metabolic process	2	5	1.35e-02
GO:BP	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process	2	7	1.35e-02
GO:BP	GO:1900262	regulation of DNA-directed DNA polymerase activity	11	13	1.37e-02
GO:BP	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	11	13	1.37e-02
GO:BP	GO:0009156	ribonucleoside monophosphate biosynthetic process	6	36	1.43e-02
GO:BP	GO:0009314	response to radiation	67	349	1.47e-02
GO:BP	GO:0009112	nucleobase metabolic process	3	27	1.47e-02
GO:BP	GO:0032467	positive regulation of cytokinesis	15	33	1.55e-02
GO:BP	GO:0090232	positive regulation of spindle checkpoint	6	12	1.56e-02
GO:BP	GO:0009200	deoxyribonucleoside triphosphate metabolic process	3	9	1.56e-02
GO:BP	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	6	12	1.56e-02
GO:BP	GO:0007143	female meiotic nuclear division	11	25	1.58e-02
GO:BP	GO:0019985	translesion synthesis	10	24	1.58e-02
GO:BP	GO:0033043	regulation of organelle organization	75	1023	1.58e-02
GO:BP	GO:0106380	purine ribonucleotide salvage	2	7	1.65e-02
GO:BP	GO:0006271	DNA strand elongation involved in DNA replication	12	15	1.68e-02
GO:BP	GO:0030509	BMP signaling pathway	3	123	1.88e-02
GO:BP	GO:0099625	ventricular cardiac muscle cell membrane repolarization	6	21	1.91e-02
GO:BP	GO:0030174	regulation of DNA-templated DNA replication initiation	7	14	1.94e-02
GO:BP	GO:1902969	mitotic DNA replication	9	14	1.95e-02
GO:BP	GO:0006301	postreplication repair	12	34	1.97e-02
GO:BP	GO:0071773	cellular response to BMP stimulus	3	131	2.20e-02
GO:BP	GO:0071772	response to BMP	3	131	2.20e-02
GO:BP	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	4	15	2.20e-02
GO:BP	GO:0031297	replication fork processing	20	42	2.20e-02
GO:BP	GO:0006284	base-excision repair	10	44	2.23e-02
GO:BP	GO:0010032	meiotic chromosome condensation	4	6	2.26e-02
GO:BP	GO:0040001	establishment of mitotic spindle localization	15	36	2.31e-02
GO:BP	GO:0086067	AV node cell to bundle of His cell communication	4	11	2.32e-02
GO:BP	GO:1905832	positive regulation of spindle assembly	5	7	2.32e-02
GO:BP	GO:1903046	meiotic cell cycle process	47	136	2.35e-02
GO:BP	GO:0044818	mitotic G2/M transition checkpoint	17	50	2.35e-02
GO:BP	GO:1902115	regulation of organelle assembly	29	186	2.35e-02
GO:BP	GO:0071480	cellular response to gamma radiation	12	29	2.35e-02
GO:BP	GO:0009170	purine deoxyribonucleoside monophosphate metabolic process	2	7	2.35e-02
GO:BP	GO:0009123	nucleoside monophosphate metabolic process	4	71	2.40e-02
GO:BP	GO:0046599	regulation of centriole replication	9	21	2.50e-02
GO:BP	GO:0046602	regulation of mitotic centrosome separation	5	8	2.52e-02
GO:BP	GO:0042148	strand invasion	4	5	2.56e-02
GO:BP	GO:1902749	regulation of cell cycle G2/M phase transition	29	102	2.56e-02
GO:BP	GO:0009124	nucleoside monophosphate biosynthetic process	3	44	2.58e-02
GO:BP	GO:1901976	regulation of cell cycle checkpoint	10	45	2.65e-02
GO:BP	GO:0046129	purine ribonucleoside biosynthetic process	2	11	2.71e-02
GO:BP	GO:0042455	ribonucleoside biosynthetic process	2	11	2.71e-02
GO:BP	GO:0042451	purine nucleoside biosynthetic process	2	11	2.71e-02
GO:BP	GO:0032261	purine nucleotide salvage	2	10	2.71e-02
GO:BP	GO:0034644	cellular response to UV	19	83	2.72e-02
GO:BP	GO:0006259	DNA metabolic process	108	890	2.76e-02
GO:BP	GO:0006175	dATP biosynthetic process	1	1	2.85e-02
GO:BP	GO:0030330	DNA damage response, signal transduction by p53 class mediator	8	68	2.87e-02
GO:BP	GO:0038202	TORC1 signaling	39	56	3.01e-02
GO:BP	GO:0140013	meiotic nuclear division	40	121	3.08e-02
GO:BP	GO:0070925	organelle assembly	141	803	3.08e-02
GO:BP	GO:2000233	negative regulation of rRNA processing	3	3	3.08e-02
GO:BP	GO:0035878	nail development	2	7	3.11e-02
GO:BP	GO:0006290	pyrimidine dimer repair	1	7	3.21e-02
GO:BP	GO:0090329	regulation of DNA-templated DNA replication	28	54	3.31e-02
GO:BP	GO:1905821	positive regulation of chromosome condensation	4	5	3.36e-02
GO:BP	GO:0007079	mitotic chromosome movement towards spindle pole	3	4	3.36e-02
GO:BP	GO:1901978	positive regulation of cell cycle checkpoint	7	19	3.39e-02
GO:BP	GO:0033260	nuclear DNA replication	6	35	3.46e-02
GO:BP	GO:0098869	cellular oxidant detoxification	6	66	3.46e-02
GO:BP	GO:0032508	DNA duplex unwinding	19	75	3.59e-02
GO:BP	GO:0034502	protein localization to chromosome	19	110	3.68e-02
GO:BP	GO:0036166	phenotypic switching	4	7	3.74e-02
GO:BP	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	19	60	3.80e-02
GO:BP	GO:0090071	negative regulation of ribosome biogenesis	4	5	3.89e-02
GO:BP	GO:0006268	DNA unwinding involved in DNA replication	10	22	3.89e-02
GO:BP	GO:0071459	protein localization to chromosome, centromeric region	9	42	3.89e-02
GO:BP	GO:1903432	regulation of TORC1 signaling	33	46	3.89e-02
GO:BP	GO:0098880	maintenance of postsynaptic specialization structure	6	7	3.92e-02
GO:BP	GO:0007076	mitotic chromosome condensation	12	19	4.00e-02
GO:BP	GO:0086012	membrane depolarization during cardiac muscle cell action potential	5	21	4.05e-02
GO:BP	GO:0006275	regulation of DNA replication	42	124	4.05e-02
GO:BP	GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization	5	16	4.05e-02
GO:BP	GO:0051299	centrosome separation	9	14	4.17e-02
GO:BP	GO:0061642	chemoattraction of axon	2	2	4.29e-02
GO:BP	GO:0009163	nucleoside biosynthetic process	2	15	4.33e-02
GO:BP	GO:0034404	nucleobase-containing small molecule biosynthetic process	2	15	4.33e-02
GO:BP	GO:0043101	purine-containing compound salvage	2	14	4.33e-02
GO:BP	GO:0008315	G2/MI transition of meiotic cell cycle	4	5	4.33e-02
GO:BP	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4	16	4.36e-02
GO:BP	GO:0036462	TRAIL-activated apoptotic signaling pathway	6	10	4.37e-02
GO:BP	GO:0085020	protein K6-linked ubiquitination	6	9	4.41e-02
GO:BP	GO:0038101	sequestering of nodal from receptor via nodal binding	1	1	4.41e-02
GO:BP	GO:0036480	neuron intrinsic apoptotic signaling pathway in response to oxidative stress	5	8	4.59e-02
GO:BP	GO:1903376	regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	5	8	4.59e-02
GO:BP	GO:0009202	deoxyribonucleoside triphosphate biosynthetic process	1	2	4.67e-02
GO:BP	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	22	72	4.67e-02
GO:BP	GO:0032506	cytokinetic process	12	39	4.67e-02
GO:BP	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	6	43	4.67e-02
GO:BP	GO:0009216	purine deoxyribonucleoside triphosphate biosynthetic process	1	2	4.67e-02
GO:BP	GO:0016321	female meiosis chromosome segregation	3	5	4.69e-02
GO:BP	GO:0036297	interstrand cross-link repair	12	37	4.95e-02
GO:BP	GO:0070914	UV-damage excision repair	1	13	4.99e-02
KEGG	KEGG:04115	p53 signaling pathway	16	65	6.55e-07
KEGG	KEGG:03410	Base excision repair	25	33	2.25e-04
KEGG	KEGG:03030	DNA replication	15	35	2.25e-04
KEGG	KEGG:03430	Mismatch repair	17	22	3.93e-03
KEGG	KEGG:04110	Cell cycle	15	121	3.93e-03
KEGG	KEGG:03440	Homologous recombination	13	39	4.07e-03
KEGG	KEGG:01524	Platinum drug resistance	22	65	1.00e-02
KEGG	KEGG:05322	Systemic lupus erythematosus	2	61	1.19e-02
KEGG	KEGG:04217	Necroptosis	2	106	1.58e-02
KEGG	KEGG:05034	Alcoholism	2	122	1.79e-02
KEGG	KEGG:04613	Neutrophil extracellular trap formation	2	110	1.79e-02
KEGG	KEGG:03460	Fanconi anemia pathway	14	48	3.30e-02
KEGG	KEGG:04964	Proximal tubule bicarbonate reclamation	2	20	3.34e-02

Epirubicin

All Epi DEGs adj p value < 0.05

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	108	1915	5.92e-24
GO:BP	GO:0006366	transcription by RNA polymerase II	109	1991	1.85e-23
GO:BP	GO:1903506	regulation of nucleic acid-templated transcription	120	2581	8.86e-21
GO:BP	GO:0097659	nucleic acid-templated transcription	122	2684	8.86e-21
GO:BP	GO:0006351	DNA-templated transcription	122	2683	8.86e-21
GO:BP	GO:0006355	regulation of DNA-templated transcription	120	2579	8.86e-21
GO:BP	GO:2001141	regulation of RNA biosynthetic process	120	2598	1.07e-20
GO:BP	GO:0032774	RNA biosynthetic process	122	2714	1.75e-20
GO:BP	GO:0051252	regulation of RNA metabolic process	125	2849	2.55e-20
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	129	3105	2.00e-19
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	124	3015	6.72e-18
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	124	3083	3.98e-17
GO:BP	GO:0031326	regulation of cellular biosynthetic process	124	3123	1.91e-16
GO:BP	GO:0018130	heterocycle biosynthetic process	124	3148	1.91e-16
GO:BP	GO:0019438	aromatic compound biosynthetic process	124	3149	2.26e-16
GO:BP	GO:0009889	regulation of biosynthetic process	124	3174	6.91e-16
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	124	3253	4.32e-15
GO:BP	GO:0009059	macromolecule biosynthetic process	131	3730	4.48e-14
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	144	4330	1.54e-13
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	130	3758	4.49e-13
GO:BP	GO:0080090	regulation of primary metabolic process	145	4440	6.75e-13
GO:BP	GO:0031323	regulation of cellular metabolic process	141	4305	1.21e-12
GO:BP	GO:0010468	regulation of gene expression	131	3583	2.93e-09
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	43	735	7.73e-09
GO:BP	GO:0044249	cellular biosynthetic process	125	4465	1.81e-08
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	50	1009	4.90e-08
GO:BP	GO:1903507	negative regulation of nucleic acid-templated transcription	50	1011	4.98e-08
GO:BP	GO:1901576	organic substance biosynthetic process	125	4537	5.54e-08
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	50	1020	6.71e-08
GO:BP	GO:0009058	biosynthetic process	125	4595	1.58e-07
GO:BP	GO:0060255	regulation of macromolecule metabolic process	146	4640	2.72e-07
GO:BP	GO:0051253	negative regulation of RNA metabolic process	51	1115	3.20e-07
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	53	1206	6.42e-07
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	53	1249	2.27e-06
GO:BP	GO:0009890	negative regulation of biosynthetic process	53	1273	4.22e-06
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	51	1215	4.79e-06
GO:BP	GO:0051254	positive regulation of RNA metabolic process	57	1431	1.11e-05
GO:BP	GO:0090304	nucleic acid metabolic process	30	4047	2.65e-05
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	53	1304	2.72e-05
GO:BP	GO:1903508	positive regulation of nucleic acid-templated transcription	53	1304	2.72e-05
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	53	1311	3.03e-05
GO:BP	GO:0031324	negative regulation of cellular metabolic process	63	1780	3.25e-05
GO:BP	GO:0019222	regulation of metabolic process	137	5039	4.19e-05
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	59	1600	6.34e-05
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	42	925	1.44e-04
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	30	4503	1.85e-04
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	63	1866	3.09e-04
GO:BP	GO:0016070	RNA metabolic process	28	3593	3.16e-04
GO:BP	GO:0046483	heterocycle metabolic process	30	4616	3.16e-04
GO:BP	GO:0019827	stem cell population maintenance	13	150	3.35e-04
GO:BP	GO:0006725	cellular aromatic compound metabolic process	30	4646	3.67e-04
GO:BP	GO:0098727	maintenance of cell number	13	152	4.11e-04
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	54	1499	4.30e-04
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	46	2425	4.88e-04
GO:BP	GO:1901360	organic cyclic compound metabolic process	30	4790	7.44e-04
GO:BP	GO:0034641	cellular nitrogen compound metabolic process	30	4991	1.27e-03
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	54	1571	1.87e-03
GO:BP	GO:0009891	positive regulation of biosynthetic process	49	1598	3.03e-03
GO:BP	GO:1902459	positive regulation of stem cell population maintenance	6	44	3.03e-03
GO:BP	GO:2000036	regulation of stem cell population maintenance	6	62	3.03e-03
GO:BP	GO:0031325	positive regulation of cellular metabolic process	43	2373	3.67e-03
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	46	2648	4.12e-03
GO:BP	GO:0035019	somatic stem cell population maintenance	7	50	4.62e-03
GO:BP	GO:1900034	regulation of cellular response to heat	4	16	5.03e-03
GO:BP	GO:1904290	negative regulation of mitotic DNA damage checkpoint	1	1	7.52e-03
GO:BP	GO:0015074	DNA integration	3	11	1.01e-02
GO:BP	GO:0006297	nucleotide-excision repair, DNA gap filling	2	5	1.40e-02
GO:BP	GO:0045444	fat cell differentiation	11	187	1.42e-02
GO:BP	GO:0006473	protein acetylation	12	208	1.64e-02
GO:BP	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	9	126	1.70e-02
GO:BP	GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	9	127	1.96e-02
GO:BP	GO:1904289	regulation of mitotic DNA damage checkpoint	1	3	2.04e-02
GO:BP	GO:1903676	positive regulation of cap-dependent translational initiation	1	1	2.31e-02
GO:BP	GO:1903674	regulation of cap-dependent translational initiation	1	1	2.31e-02
GO:BP	GO:0010944	negative regulation of transcription by competitive promoter binding	2	8	2.39e-02
GO:BP	GO:0045643	regulation of eosinophil differentiation	1	1	2.51e-02
GO:BP	GO:0045659	negative regulation of neutrophil differentiation	1	2	2.51e-02
GO:BP	GO:0045645	positive regulation of eosinophil differentiation	1	1	2.51e-02
GO:BP	GO:0002763	positive regulation of myeloid leukocyte differentiation	2	34	2.66e-02
GO:BP	GO:0009893	positive regulation of metabolic process	46	2884	2.70e-02
GO:BP	GO:0045658	regulation of neutrophil differentiation	1	2	3.57e-02
GO:BP	GO:2000002	negative regulation of DNA damage checkpoint	1	5	3.57e-02
GO:BP	GO:0003151	outflow tract morphogenesis	6	66	3.57e-02
GO:BP	GO:0006968	cellular defense response	2	15	3.66e-02
GO:BP	GO:0048538	thymus development	5	35	4.01e-02
GO:BP	GO:0006325	chromatin organization	21	536	4.02e-02
GO:BP	GO:0060411	cardiac septum morphogenesis	4	67	4.33e-02
GO:BP	GO:0043543	protein acylation	8	246	4.52e-02
GO:BP	GO:0030853	negative regulation of granulocyte differentiation	2	6	4.61e-02
GO:BP	GO:1900036	positive regulation of cellular response to heat	1	1	4.62e-02
GO:BP	GO:0003281	ventricular septum development	4	69	4.69e-02
GO:BP	GO:0018394	peptidyl-lysine acetylation	10	180	4.69e-02
GO:BP	GO:0055025	positive regulation of cardiac muscle tissue development	1	2	4.69e-02
GO:BP	GO:0018076	N-terminal peptidyl-lysine acetylation	2	4	4.69e-02
GO:BP	GO:0060324	face development	5	44	4.69e-02
GO:BP	GO:0043923	positive regulation by host of viral transcription	3	17	4.69e-02
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	12	229	4.87e-02
GO:BP	GO:0030222	eosinophil differentiation	1	2	4.94e-02
GO:BP	GO:1901977	negative regulation of cell cycle checkpoint	1	8	4.94e-02
GO:BP	GO:0090721	primary adaptive immune response involving T cells and B cells	1	1	4.98e-02
GO:BP	GO:0090720	primary adaptive immune response	1	1	4.98e-02
GO:BP	GO:1903677	regulation of cap-independent translational initiation	1	3	4.98e-02
GO:BP	GO:1903679	positive regulation of cap-independent translational initiation	1	3	4.98e-02
KEGG	KEGG:05168	Herpes simplex virus 1 infection	31	415	7.79e-09

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0007059	chromosome segregation	103	378	4.04e-11
GO:BP	GO:0000278	mitotic cell cycle	210	833	5.51e-11
GO:BP	GO:0000819	sister chromatid segregation	70	234	1.28e-10
GO:BP	GO:0000070	mitotic sister chromatid segregation	61	193	1.53e-10
GO:BP	GO:1903047	mitotic cell cycle process	178	700	5.35e-10
GO:BP	GO:0140014	mitotic nuclear division	44	264	6.38e-10
GO:BP	GO:0098813	nuclear chromosome segregation	80	287	1.10e-08
GO:BP	GO:0010564	regulation of cell cycle process	111	620	1.10e-08
GO:BP	GO:0051276	chromosome organization	122	543	3.28e-08
GO:BP	GO:0007093	mitotic cell cycle checkpoint signaling	45	136	5.05e-08
GO:BP	GO:0051726	regulation of cell cycle	151	950	5.99e-08
GO:BP	GO:0045930	negative regulation of mitotic cell cycle	68	208	7.02e-08
GO:BP	GO:0051301	cell division	129	567	8.59e-08
GO:BP	GO:0000075	cell cycle checkpoint signaling	53	180	1.40e-07
GO:BP	GO:0000280	nuclear division	115	354	3.17e-07
GO:BP	GO:0022402	cell cycle process	165	1075	3.96e-07
GO:BP	GO:0007049	cell cycle	217	1522	1.11e-06
GO:BP	GO:0008608	attachment of spindle microtubules to kinetochore	20	42	1.82e-06
GO:BP	GO:0007051	spindle organization	29	186	4.05e-06
GO:BP	GO:0051983	regulation of chromosome segregation	37	118	4.34e-06
GO:BP	GO:0007052	mitotic spindle organization	28	128	4.34e-06
GO:BP	GO:0048285	organelle fission	119	397	5.95e-06
GO:BP	GO:1905818	regulation of chromosome separation	26	69	1.07e-05
GO:BP	GO:0045786	negative regulation of cell cycle	96	334	1.07e-05
GO:BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	35	156	1.41e-05
GO:BP	GO:0030071	regulation of mitotic metaphase/anaphase transition	29	88	1.76e-05
GO:BP	GO:0007346	regulation of mitotic cell cycle	110	438	1.78e-05
GO:BP	GO:2001251	negative regulation of chromosome organization	30	90	2.02e-05
GO:BP	GO:0051225	spindle assembly	36	118	2.07e-05
GO:BP	GO:0010948	negative regulation of cell cycle process	65	270	3.12e-05
GO:BP	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	29	91	3.12e-05
GO:BP	GO:1901988	negative regulation of cell cycle phase transition	58	232	3.12e-05
GO:BP	GO:1902099	regulation of metaphase/anaphase transition of cell cycle	29	89	3.12e-05
GO:BP	GO:0007080	mitotic metaphase plate congression	14	55	3.28e-05
GO:BP	GO:0071174	mitotic spindle checkpoint signaling	16	44	3.88e-05
GO:BP	GO:0007094	mitotic spindle assembly checkpoint signaling	16	44	3.88e-05
GO:BP	GO:0071173	spindle assembly checkpoint signaling	16	44	3.88e-05
GO:BP	GO:0051304	chromosome separation	26	74	4.03e-05
GO:BP	GO:0045839	negative regulation of mitotic nuclear division	21	54	4.43e-05
GO:BP	GO:0006974	cellular response to DNA damage stimulus	150	789	4.43e-05
GO:BP	GO:0031577	spindle checkpoint signaling	16	45	4.90e-05
GO:BP	GO:0044784	metaphase/anaphase transition of cell cycle	29	92	5.09e-05
GO:BP	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	19	46	6.08e-05
GO:BP	GO:0010965	regulation of mitotic sister chromatid separation	14	58	6.08e-05
GO:BP	GO:0044774	mitotic DNA integrity checkpoint signaling	28	82	6.08e-05
GO:BP	GO:0031570	DNA integrity checkpoint signaling	37	126	6.82e-05
GO:BP	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	11	18	7.36e-05
GO:BP	GO:0033045	regulation of sister chromatid segregation	30	99	7.77e-05
GO:BP	GO:0033047	regulation of mitotic sister chromatid segregation	17	52	7.77e-05
GO:BP	GO:0051310	metaphase plate congression	15	69	7.77e-05
GO:BP	GO:0051783	regulation of nuclear division	30	115	8.44e-05
GO:BP	GO:2000816	negative regulation of mitotic sister chromatid separation	16	47	9.08e-05
GO:BP	GO:1902100	negative regulation of metaphase/anaphase transition of cell cycle	16	47	9.08e-05
GO:BP	GO:0033046	negative regulation of sister chromatid segregation	16	47	9.08e-05
GO:BP	GO:0006281	DNA repair	107	535	9.08e-05
GO:BP	GO:0033048	negative regulation of mitotic sister chromatid segregation	16	47	9.08e-05
GO:BP	GO:0051306	mitotic sister chromatid separation	14	61	9.08e-05
GO:BP	GO:0006260	DNA replication	83	258	9.68e-05
GO:BP	GO:0006261	DNA-templated DNA replication	54	149	1.06e-04
GO:BP	GO:0007088	regulation of mitotic nuclear division	27	100	1.06e-04
GO:BP	GO:0000226	microtubule cytoskeleton organization	85	552	1.10e-04
GO:BP	GO:0033044	regulation of chromosome organization	53	233	1.24e-04
GO:BP	GO:1905819	negative regulation of chromosome separation	16	48	1.45e-04
GO:BP	GO:0051985	negative regulation of chromosome segregation	16	48	1.45e-04
GO:BP	GO:0090068	positive regulation of cell cycle process	61	206	1.53e-04
GO:BP	GO:1901987	regulation of cell cycle phase transition	64	388	1.60e-04
GO:BP	GO:0044772	mitotic cell cycle phase transition	97	413	1.67e-04
GO:BP	GO:0051231	spindle elongation	9	12	1.84e-04
GO:BP	GO:1901991	negative regulation of mitotic cell cycle phase transition	48	163	1.84e-04
GO:BP	GO:0044773	mitotic DNA damage checkpoint signaling	26	78	1.84e-04
GO:BP	GO:0051256	mitotic spindle midzone assembly	8	9	1.85e-04
GO:BP	GO:1901990	regulation of mitotic cell cycle phase transition	76	305	2.00e-04
GO:BP	GO:0050000	chromosome localization	16	82	2.21e-04
GO:BP	GO:0000077	DNA damage checkpoint signaling	34	118	2.21e-04
GO:BP	GO:0051784	negative regulation of nuclear division	21	57	2.21e-04
GO:BP	GO:0044770	cell cycle phase transition	114	499	2.21e-04
GO:BP	GO:0051984	positive regulation of chromosome segregation	16	25	2.55e-04
GO:BP	GO:0090307	mitotic spindle assembly	17	69	2.87e-04
GO:BP	GO:0051255	spindle midzone assembly	9	12	3.19e-04
GO:BP	GO:0051303	establishment of chromosome localization	15	75	3.67e-04
GO:BP	GO:0000022	mitotic spindle elongation	8	10	4.44e-04
GO:BP	GO:0032465	regulation of cytokinesis	25	79	5.27e-04
GO:BP	GO:0042770	signal transduction in response to DNA damage	34	173	5.54e-04
GO:BP	GO:0060236	regulation of mitotic spindle organization	8	42	5.98e-04
GO:BP	GO:0000086	G2/M transition of mitotic cell cycle	37	134	8.65e-04
GO:BP	GO:0006275	regulation of DNA replication	45	124	9.91e-04
GO:BP	GO:0006541	glutamine metabolic process	4	23	1.07e-03
GO:BP	GO:0010639	negative regulation of organelle organization	64	318	1.08e-03
GO:BP	GO:0090224	regulation of spindle organization	8	45	1.10e-03
GO:BP	GO:0010389	regulation of G2/M transition of mitotic cell cycle	30	92	1.19e-03
GO:BP	GO:0033043	regulation of organelle organization	172	1023	1.21e-03
GO:BP	GO:0051383	kinetochore organization	9	23	1.33e-03
GO:BP	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	10	21	1.36e-03
GO:BP	GO:0044839	cell cycle G2/M phase transition	39	148	1.49e-03
GO:BP	GO:0006270	DNA replication initiation	18	35	1.61e-03
GO:BP	GO:0090329	regulation of DNA-templated DNA replication	24	54	1.80e-03
GO:BP	GO:0000731	DNA synthesis involved in DNA repair	15	36	2.11e-03
GO:BP	GO:0051302	regulation of cell division	24	144	2.15e-03
GO:BP	GO:0010212	response to ionizing radiation	35	130	2.93e-03
GO:BP	GO:0006301	postreplication repair	11	34	3.17e-03
GO:BP	GO:0006271	DNA strand elongation involved in DNA replication	13	15	4.18e-03
GO:BP	GO:0071478	cellular response to radiation	41	155	4.57e-03
GO:BP	GO:1901976	regulation of cell cycle checkpoint	13	45	4.57e-03
GO:BP	GO:1903490	positive regulation of mitotic cytokinesis	6	7	4.57e-03
GO:BP	GO:1905820	positive regulation of chromosome separation	11	26	4.81e-03
GO:BP	GO:0019985	translesion synthesis	9	24	4.87e-03
GO:BP	GO:0000281	mitotic cytokinesis	17	81	5.93e-03
GO:BP	GO:0009411	response to UV	34	137	5.93e-03
GO:BP	GO:0044818	mitotic G2/M transition checkpoint	17	50	6.56e-03
GO:BP	GO:0060623	regulation of chromosome condensation	6	9	7.13e-03
GO:BP	GO:0007017	microtubule-based process	65	756	7.38e-03
GO:BP	GO:1902412	regulation of mitotic cytokinesis	7	8	7.58e-03
GO:BP	GO:0006167	AMP biosynthetic process	3	14	8.10e-03
GO:BP	GO:0044314	protein K27-linked ubiquitination	8	8	8.43e-03
GO:BP	GO:1902749	regulation of cell cycle G2/M phase transition	30	102	8.48e-03
GO:BP	GO:0030510	regulation of BMP signaling pathway	4	84	8.48e-03
GO:BP	GO:0045005	DNA-templated DNA replication maintenance of fidelity	17	50	8.48e-03
GO:BP	GO:0007095	mitotic G2 DNA damage checkpoint signaling	13	35	8.85e-03
GO:BP	GO:0006177	GMP biosynthetic process	3	14	9.58e-03
GO:BP	GO:0104004	cellular response to environmental stimulus	62	264	9.75e-03
GO:BP	GO:0071214	cellular response to abiotic stimulus	62	264	9.75e-03
GO:BP	GO:0036166	phenotypic switching	5	7	9.90e-03
GO:BP	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	19	60	1.02e-02
GO:BP	GO:1902425	positive regulation of attachment of mitotic spindle microtubules to kinetochore	6	8	1.04e-02
GO:BP	GO:1902423	regulation of attachment of mitotic spindle microtubules to kinetochore	6	8	1.04e-02
GO:BP	GO:0034644	cellular response to UV	23	83	1.05e-02
GO:BP	GO:0046060	dATP metabolic process	2	3	1.05e-02
GO:BP	GO:0000910	cytokinesis	20	163	1.10e-02
GO:BP	GO:0032508	DNA duplex unwinding	24	75	1.11e-02
GO:BP	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore	7	11	1.19e-02
GO:BP	GO:0044786	cell cycle DNA replication	18	40	1.29e-02
GO:BP	GO:0009314	response to radiation	59	349	1.43e-02
GO:BP	GO:0045787	positive regulation of cell cycle	70	278	1.46e-02
GO:BP	GO:1902750	negative regulation of cell cycle G2/M phase transition	19	62	1.49e-02
GO:BP	GO:0046037	GMP metabolic process	4	24	1.59e-02
GO:BP	GO:0046602	regulation of mitotic centrosome separation	6	8	1.64e-02
GO:BP	GO:0140013	meiotic nuclear division	44	121	1.65e-02
GO:BP	GO:0071897	DNA biosynthetic process	55	175	1.74e-02
GO:BP	GO:0099625	ventricular cardiac muscle cell membrane repolarization	5	21	1.75e-02
GO:BP	GO:1903046	meiotic cell cycle process	47	136	1.75e-02
GO:BP	GO:0030174	regulation of DNA-templated DNA replication initiation	9	14	1.80e-02
GO:BP	GO:0060371	regulation of atrial cardiac muscle cell membrane depolarization	3	7	1.91e-02
GO:BP	GO:0007098	centrosome cycle	23	126	1.99e-02
GO:BP	GO:0006259	DNA metabolic process	154	890	1.99e-02
GO:BP	GO:0007079	mitotic chromosome movement towards spindle pole	3	4	2.08e-02
GO:BP	GO:0071480	cellular response to gamma radiation	17	29	2.23e-02
GO:BP	GO:0007076	mitotic chromosome condensation	8	19	2.25e-02
GO:BP	GO:0061642	chemoattraction of axon	2	2	2.26e-02
GO:BP	GO:0061640	cytoskeleton-dependent cytokinesis	20	103	2.28e-02
GO:BP	GO:0086067	AV node cell to bundle of His cell communication	7	11	2.35e-02
GO:BP	GO:0000302	response to reactive oxygen species	24	160	2.35e-02
GO:BP	GO:0034502	protein localization to chromosome	14	110	2.40e-02
GO:BP	GO:0042148	strand invasion	4	5	2.58e-02
GO:BP	GO:0009168	purine ribonucleoside monophosphate biosynthetic process	3	22	2.78e-02
GO:BP	GO:0006268	DNA unwinding involved in DNA replication	11	22	2.79e-02
GO:BP	GO:0032263	GMP salvage	2	4	2.82e-02
GO:BP	GO:0044209	AMP salvage	2	5	2.82e-02
GO:BP	GO:0031023	microtubule organizing center organization	24	136	2.84e-02
GO:BP	GO:0032392	DNA geometric change	28	81	2.85e-02
GO:BP	GO:0062197	cellular response to chemical stress	43	290	2.85e-02
GO:BP	GO:0014029	neural crest formation	7	13	2.85e-02
GO:BP	GO:0030509	BMP signaling pathway	4	123	2.99e-02
GO:BP	GO:0009064	glutamine family amino acid metabolic process	3	61	2.99e-02
GO:BP	GO:0002227	innate immune response in mucosa	5	8	3.03e-02
GO:BP	GO:0086012	membrane depolarization during cardiac muscle cell action potential	9	21	3.04e-02
GO:BP	GO:1902969	mitotic DNA replication	11	14	3.04e-02
GO:BP	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	11	13	3.13e-02
GO:BP	GO:0051299	centrosome separation	13	14	3.13e-02
GO:BP	GO:0007062	sister chromatid cohesion	29	51	3.13e-02
GO:BP	GO:1900262	regulation of DNA-directed DNA polymerase activity	11	13	3.13e-02
GO:BP	GO:0030330	DNA damage response, signal transduction by p53 class mediator	10	68	3.13e-02
GO:BP	GO:0046033	AMP metabolic process	3	22	3.17e-02
GO:BP	GO:0009127	purine nucleoside monophosphate biosynthetic process	3	24	3.17e-02
GO:BP	GO:0034599	cellular response to oxidative stress	37	239	3.17e-02
GO:BP	GO:0099558	maintenance of synapse structure	8	20	3.17e-02
GO:BP	GO:1905821	positive regulation of chromosome condensation	4	5	3.19e-02
GO:BP	GO:0086027	AV node cell to bundle of His cell signaling	3	9	3.19e-02
GO:BP	GO:0086016	AV node cell action potential	3	9	3.19e-02
GO:BP	GO:1905832	positive regulation of spindle assembly	5	7	3.19e-02
GO:BP	GO:0042542	response to hydrogen peroxide	17	103	3.28e-02
GO:BP	GO:0140694	non-membrane-bounded organelle assembly	63	355	3.28e-02
GO:BP	GO:0060444	branching involved in mammary gland duct morphogenesis	12	20	3.28e-02
GO:BP	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	6	12	3.28e-02
GO:BP	GO:0090232	positive regulation of spindle checkpoint	6	12	3.28e-02
GO:BP	GO:0071773	cellular response to BMP stimulus	4	131	3.37e-02
GO:BP	GO:0071772	response to BMP	4	131	3.37e-02
GO:BP	GO:0090235	regulation of metaphase plate congression	7	13	3.40e-02
GO:BP	GO:0006290	pyrimidine dimer repair	1	7	3.41e-02
GO:BP	GO:0034501	protein localization to kinetochore	11	18	3.49e-02
GO:BP	GO:1903083	protein localization to condensed chromosome	11	18	3.49e-02
GO:BP	GO:0006285	base-excision repair, AP site formation	10	12	3.54e-02
GO:BP	GO:0010032	meiotic chromosome condensation	4	6	3.54e-02
GO:BP	GO:0046601	positive regulation of centriole replication	8	9	3.54e-02
GO:BP	GO:0006979	response to oxidative stress	41	349	3.54e-02
GO:BP	GO:0006284	base-excision repair	27	44	3.63e-02
GO:BP	GO:1901751	leukotriene A4 metabolic process	2	2	3.78e-02
GO:BP	GO:0009084	glutamine family amino acid biosynthetic process	2	17	3.87e-02
GO:BP	GO:0071103	DNA conformation change	22	88	3.87e-02
GO:BP	GO:0046112	nucleobase biosynthetic process	9	18	3.91e-02
GO:BP	GO:0060509	type I pneumocyte differentiation	8	8	3.99e-02
GO:BP	GO:0033260	nuclear DNA replication	15	35	4.05e-02
GO:BP	GO:1902115	regulation of organelle assembly	18	186	4.20e-02
GO:BP	GO:0046053	dAMP metabolic process	2	5	4.50e-02
GO:BP	GO:0009215	purine deoxyribonucleoside triphosphate metabolic process	2	7	4.50e-02
GO:BP	GO:1990227	paranodal junction maintenance	1	2	4.50e-02
GO:BP	GO:0051321	meiotic cell cycle	57	188	4.50e-02
GO:BP	GO:0010332	response to gamma radiation	26	50	4.51e-02
GO:BP	GO:0045132	meiotic chromosome segregation	23	69	4.76e-02
GO:BP	GO:0051298	centrosome duplication	4	68	4.83e-02
GO:BP	GO:1902117	positive regulation of organelle assembly	10	75	5.00e-02
KEGG	KEGG:04115	p53 signaling pathway	10	65	1.37e-05
KEGG	KEGG:04110	Cell cycle	13	121	1.00e-04
KEGG	KEGG:03410	Base excision repair	26	33	2.70e-04
KEGG	KEGG:03030	DNA replication	13	35	4.66e-04
KEGG	KEGG:03430	Mismatch repair	16	22	3.99e-03
KEGG	KEGG:03440	Homologous recombination	11	39	7.47e-03
KEGG	KEGG:05322	Systemic lupus erythematosus	12	61	1.09e-02
KEGG	KEGG:05034	Alcoholism	7	122	1.12e-02
KEGG	KEGG:04217	Necroptosis	7	106	1.19e-02
KEGG	KEGG:04613	Neutrophil extracellular trap formation	2	110	1.96e-02
KEGG	KEGG:01524	Platinum drug resistance	17	65	4.11e-02
KEGG	KEGG:04964	Proximal tubule bicarbonate reclamation	2	20	4.86e-02

Epirubicin specific genes at 24 hours n= 489 genes are starting to show some apoptosis enrichment for myeloid cells.

Mitoxantrone _specific 24 hour genes show an enrichment for DNA DSB repair. (n=188)

Mitoxantrone DEGs (adj. p value < 0.05)

3 hour = 58 24 hour = 1327

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0051252	regulation of RNA metabolic process	33	2849	6.85e-08
GO:BP	GO:2001141	regulation of RNA biosynthetic process	31	2598	1.10e-07
GO:BP	GO:1903506	regulation of nucleic acid-templated transcription	31	2581	1.10e-07
GO:BP	GO:0006355	regulation of DNA-templated transcription	31	2579	1.10e-07
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	33	3105	1.30e-07
GO:BP	GO:0006351	DNA-templated transcription	31	2683	1.30e-07
GO:BP	GO:0097659	nucleic acid-templated transcription	31	2684	1.30e-07
GO:BP	GO:0032774	RNA biosynthetic process	31	2714	1.50e-07
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	32	3015	2.26e-07
GO:BP	GO:0031326	regulation of cellular biosynthetic process	32	3123	6.03e-07
GO:BP	GO:0009889	regulation of biosynthetic process	32	3174	8.48e-07
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	28	1915	1.62e-06
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	31	3083	2.09e-06
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	36	4330	2.81e-06
GO:BP	GO:0019438	aromatic compound biosynthetic process	31	3149	2.81e-06
GO:BP	GO:0018130	heterocycle biosynthetic process	31	3148	2.81e-06
GO:BP	GO:0006366	transcription by RNA polymerase II	28	1991	2.81e-06
GO:BP	GO:0010468	regulation of gene expression	35	3583	4.67e-06
GO:BP	GO:0080090	regulation of primary metabolic process	36	4440	5.49e-06
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	31	3253	5.86e-06
GO:BP	GO:0031323	regulation of cellular metabolic process	35	4305	9.38e-06
GO:BP	GO:0009059	macromolecule biosynthetic process	32	3730	1.87e-05
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	10	735	2.39e-05
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	32	3758	2.47e-05
GO:BP	GO:0051890	regulation of cardioblast differentiation	3	7	8.49e-05
GO:BP	GO:0051253	negative regulation of RNA metabolic process	11	1115	8.90e-05
GO:BP	GO:0031324	negative regulation of cellular metabolic process	13	1780	1.13e-04
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	11	1206	1.61e-04
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	11	1215	1.86e-04
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	11	1249	2.18e-04
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	13	1866	2.18e-04
GO:BP	GO:0009890	negative regulation of biosynthetic process	11	1273	2.49e-04
GO:BP	GO:1903507	negative regulation of nucleic acid-templated transcription	10	1011	2.86e-04
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	10	1009	2.86e-04
GO:BP	GO:0060255	regulation of macromolecule metabolic process	36	4640	2.97e-04
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	10	1020	2.97e-04
GO:BP	GO:0060411	cardiac septum morphogenesis	5	67	4.18e-04
GO:BP	GO:0051254	positive regulation of RNA metabolic process	20	1431	6.36e-04
GO:BP	GO:0060419	heart growth	5	72	9.71e-04
GO:BP	GO:0035051	cardiocyte differentiation	6	129	9.88e-04
GO:BP	GO:0036490	regulation of translation in response to endoplasmic reticulum stress	2	11	9.89e-04
GO:BP	GO:0044249	cellular biosynthetic process	32	4465	1.04e-03
GO:BP	GO:0010002	cardioblast differentiation	3	17	1.14e-03
GO:BP	GO:0110021	cardiac muscle myoblast proliferation	2	3	1.21e-03
GO:BP	GO:0110022	regulation of cardiac muscle myoblast proliferation	2	3	1.21e-03
GO:BP	GO:0110024	positive regulation of cardiac muscle myoblast proliferation	2	3	1.21e-03
GO:BP	GO:0051891	positive regulation of cardioblast differentiation	2	6	1.24e-03
GO:BP	GO:1901576	organic substance biosynthetic process	32	4537	1.35e-03
GO:BP	GO:0035265	organ growth	6	129	1.63e-03
GO:BP	GO:0016070	RNA metabolic process	35	3593	1.69e-03
GO:BP	GO:0003148	outflow tract septum morphogenesis	3	23	1.75e-03
GO:BP	GO:0019222	regulation of metabolic process	36	5039	1.75e-03
GO:BP	GO:0009058	biosynthetic process	32	4595	1.75e-03
GO:BP	GO:0003162	atrioventricular node development	2	8	1.98e-03
GO:BP	GO:1905207	regulation of cardiocyte differentiation	3	24	1.98e-03
GO:BP	GO:1903508	positive regulation of nucleic acid-templated transcription	18	1304	1.98e-03
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	18	1304	1.98e-03
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	20	1600	2.02e-03
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	18	1311	2.02e-03
GO:BP	GO:0003279	cardiac septum development	5	101	2.03e-03
GO:BP	GO:0055017	cardiac muscle tissue growth	4	65	2.09e-03
GO:BP	GO:1900036	positive regulation of cellular response to heat	1	1	2.22e-03
GO:BP	GO:0055007	cardiac muscle cell differentiation	5	102	2.22e-03
GO:BP	GO:0090304	nucleic acid metabolic process	36	4047	2.64e-03
GO:BP	GO:0007507	heart development	10	502	2.74e-03
GO:BP	GO:0060420	regulation of heart growth	4	50	2.82e-03
GO:BP	GO:0043555	regulation of translation in response to stress	2	23	3.02e-03
GO:BP	GO:0003206	cardiac chamber morphogenesis	5	109	3.60e-03
GO:BP	GO:0003181	atrioventricular valve morphogenesis	2	24	3.67e-03
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	13	2146	4.30e-03
GO:BP	GO:0036302	atrioventricular canal development	2	12	4.30e-03
GO:BP	GO:0003171	atrioventricular valve development	2	26	4.46e-03
GO:BP	GO:0003281	ventricular septum development	4	69	5.14e-03
GO:BP	GO:1905209	positive regulation of cardiocyte differentiation	2	13	5.47e-03
GO:BP	GO:0003180	aortic valve morphogenesis	2	27	6.04e-03
GO:BP	GO:0048738	cardiac muscle tissue development	6	198	6.25e-03
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	14	925	6.42e-03
GO:BP	GO:0060421	positive regulation of heart growth	3	27	6.59e-03
GO:BP	GO:0045596	negative regulation of cell differentiation	10	478	6.68e-03
GO:BP	GO:0072164	mesonephric tubule development	2	76	7.17e-03
GO:BP	GO:0001657	ureteric bud development	2	75	7.17e-03
GO:BP	GO:0003176	aortic valve development	2	31	7.17e-03
GO:BP	GO:0072163	mesonephric epithelium development	2	76	7.17e-03
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	18	1499	7.17e-03
GO:BP	GO:0060976	coronary vasculature development	3	44	7.17e-03
GO:BP	GO:0009892	negative regulation of metabolic process	13	2306	7.17e-03
GO:BP	GO:0031325	positive regulation of cellular metabolic process	24	2373	7.45e-03
GO:BP	GO:0001823	mesonephros development	2	77	7.57e-03
GO:BP	GO:0014706	striated muscle tissue development	6	210	7.73e-03
GO:BP	GO:1905314	semi-lunar valve development	2	35	8.29e-03
GO:BP	GO:0046620	regulation of organ growth	4	70	8.46e-03
GO:BP	GO:1902010	negative regulation of translation in response to endoplasmic reticulum stress	1	1	9.10e-03
GO:BP	GO:0030510	regulation of BMP signaling pathway	3	84	9.47e-03
GO:BP	GO:0003007	heart morphogenesis	6	212	1.01e-02
GO:BP	GO:0055021	regulation of cardiac muscle tissue growth	3	45	1.04e-02
GO:BP	GO:0003205	cardiac chamber development	5	149	1.04e-02
GO:BP	GO:2000738	positive regulation of stem cell differentiation	2	20	1.08e-02
GO:BP	GO:0060575	intestinal epithelial cell differentiation	2	17	1.08e-02
GO:BP	GO:0009887	animal organ morphogenesis	11	739	1.10e-02
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	18	1571	1.11e-02
GO:BP	GO:0007352	zygotic specification of dorsal/ventral axis	1	2	1.11e-02
GO:BP	GO:0009893	positive regulation of metabolic process	27	2884	1.16e-02
GO:BP	GO:2000288	positive regulation of myoblast proliferation	2	9	1.16e-02
GO:BP	GO:1903674	regulation of cap-dependent translational initiation	1	1	1.17e-02
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	3	79	1.17e-02
GO:BP	GO:1903676	positive regulation of cap-dependent translational initiation	1	1	1.17e-02
GO:BP	GO:0046622	positive regulation of organ growth	3	33	1.17e-02
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	36	4503	1.18e-02
GO:BP	GO:0072073	kidney epithelium development	2	112	1.22e-02
GO:BP	GO:0003179	heart valve morphogenesis	2	50	1.22e-02
GO:BP	GO:0009891	positive regulation of biosynthetic process	18	1598	1.28e-02
GO:BP	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	2	10	1.31e-02
GO:BP	GO:0090720	primary adaptive immune response	1	1	1.33e-02
GO:BP	GO:0090721	primary adaptive immune response involving T cells and B cells	1	1	1.33e-02
GO:BP	GO:0034504	protein localization to nucleus	6	274	1.33e-02
GO:BP	GO:0048565	digestive tract development	3	91	1.51e-02
GO:BP	GO:0046483	heterocycle metabolic process	14	4616	1.60e-02
GO:BP	GO:0003170	heart valve development	2	57	1.60e-02
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	25	2648	1.66e-02
GO:BP	GO:0060537	muscle tissue development	7	340	1.72e-02
GO:BP	GO:0006725	cellular aromatic compound metabolic process	14	4646	1.72e-02
GO:BP	GO:2000291	regulation of myoblast proliferation	2	11	1.77e-02
GO:BP	GO:0055123	digestive system development	3	99	1.83e-02
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	23	2425	1.87e-02
GO:BP	GO:0051170	import into nucleus	4	151	1.89e-02
GO:BP	GO:1900034	regulation of cellular response to heat	1	16	1.89e-02
GO:BP	GO:0003215	cardiac right ventricle morphogenesis	2	17	1.97e-02
GO:BP	GO:0010665	regulation of cardiac muscle cell apoptotic process	2	34	1.97e-02
GO:BP	GO:0003151	outflow tract morphogenesis	3	66	2.03e-02
GO:BP	GO:0003161	cardiac conduction system development	2	34	2.04e-02
GO:BP	GO:0030513	positive regulation of BMP signaling pathway	2	34	2.08e-02
GO:BP	GO:2000736	regulation of stem cell differentiation	3	74	2.08e-02
GO:BP	GO:1904003	negative regulation of sebum secreting cell proliferation	1	1	2.08e-02
GO:BP	GO:0010991	negative regulation of SMAD protein complex assembly	1	5	2.08e-02
GO:BP	GO:0003290	atrial septum secundum morphogenesis	1	2	2.08e-02
GO:BP	GO:0009725	response to hormone	4	629	2.10e-02
GO:BP	GO:0035904	aorta development	3	49	2.10e-02
GO:BP	GO:0010659	cardiac muscle cell apoptotic process	2	36	2.10e-02
GO:BP	GO:0003231	cardiac ventricle development	4	114	2.10e-02
GO:BP	GO:0030509	BMP signaling pathway	3	123	2.10e-02
GO:BP	GO:0010662	regulation of striated muscle cell apoptotic process	2	37	2.10e-02
GO:BP	GO:0055012	ventricular cardiac muscle cell differentiation	2	15	2.10e-02
GO:BP	GO:1901360	organic cyclic compound metabolic process	14	4790	2.13e-02
GO:BP	GO:0003300	cardiac muscle hypertrophy	3	72	2.19e-02
GO:BP	GO:0021756	striatum development	2	17	2.24e-02
GO:BP	GO:0006913	nucleocytoplasmic transport	4	294	2.25e-02
GO:BP	GO:0010990	regulation of SMAD protein complex assembly	1	6	2.25e-02
GO:BP	GO:0051169	nuclear transport	4	294	2.25e-02
GO:BP	GO:0032055	negative regulation of translation in response to stress	1	4	2.25e-02
GO:BP	GO:0010658	striated muscle cell apoptotic process	2	39	2.25e-02
GO:BP	GO:0021542	dentate gyrus development	2	10	2.25e-02
GO:BP	GO:0014897	striated muscle hypertrophy	3	73	2.30e-02
GO:BP	GO:0071773	cellular response to BMP stimulus	3	131	2.31e-02
GO:BP	GO:0071772	response to BMP	3	131	2.31e-02
GO:BP	GO:0009880	embryonic pattern specification	3	50	2.35e-02
GO:BP	GO:0060045	positive regulation of cardiac muscle cell proliferation	2	21	2.35e-02
GO:BP	GO:1902882	regulation of response to oxidative stress	2	77	2.35e-02
GO:BP	GO:1903677	regulation of cap-independent translational initiation	1	3	2.35e-02
GO:BP	GO:0014896	muscle hypertrophy	3	74	2.35e-02
GO:BP	GO:1903679	positive regulation of cap-independent translational initiation	1	3	2.35e-02
GO:BP	GO:0009749	response to glucose	3	139	2.38e-02
GO:BP	GO:0003301	physiological cardiac muscle hypertrophy	2	19	2.38e-02
GO:BP	GO:0003298	physiological muscle hypertrophy	2	19	2.38e-02
GO:BP	GO:0061049	cell growth involved in cardiac muscle cell development	2	19	2.38e-02
GO:BP	GO:0034641	cellular nitrogen compound metabolic process	14	4991	2.43e-02
GO:BP	GO:0009746	response to hexose	3	140	2.45e-02
GO:BP	GO:1904504	positive regulation of lipophagy	1	5	2.45e-02
GO:BP	GO:1904502	regulation of lipophagy	1	5	2.45e-02
GO:BP	GO:0035054	embryonic heart tube anterior/posterior pattern specification	1	2	2.45e-02
GO:BP	GO:0003285	septum secundum development	1	3	2.45e-02
GO:BP	GO:0071495	cellular response to endogenous stimulus	5	1091	2.45e-02
GO:BP	GO:0034284	response to monosaccharide	3	144	2.72e-02
GO:BP	GO:2000257	regulation of protein activation cascade	1	1	2.87e-02
GO:BP	GO:1990441	negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1	4	2.87e-02
GO:BP	GO:0002190	cap-independent translational initiation	1	4	2.87e-02
GO:BP	GO:0003208	cardiac ventricle morphogenesis	3	62	2.90e-02
GO:BP	GO:2000691	negative regulation of cardiac muscle cell myoblast differentiation	1	1	2.95e-02
GO:BP	GO:2000690	regulation of cardiac muscle cell myoblast differentiation	1	1	2.95e-02
GO:BP	GO:0051450	myoblast proliferation	2	17	2.95e-02
GO:BP	GO:0003417	growth plate cartilage development	1	14	2.95e-02
GO:BP	GO:0021544	subpallium development	2	18	2.97e-02
GO:BP	GO:0055023	positive regulation of cardiac muscle tissue growth	2	24	2.97e-02
GO:BP	GO:0007493	endodermal cell fate determination	1	1	2.97e-02
GO:BP	GO:0032912	negative regulation of transforming growth factor beta2 production	1	2	2.97e-02
GO:BP	GO:0001949	sebaceous gland cell differentiation	1	1	2.97e-02
GO:BP	GO:1904002	regulation of sebum secreting cell proliferation	1	1	2.97e-02
GO:BP	GO:0003183	mitral valve morphogenesis	1	10	2.97e-02
GO:BP	GO:1901390	positive regulation of transforming growth factor beta activation	1	2	2.97e-02
GO:BP	GO:0010467	gene expression	27	4572	2.97e-02
GO:BP	GO:0051093	negative regulation of developmental process	10	659	2.98e-02
GO:BP	GO:0072359	circulatory system development	10	879	3.01e-02
GO:BP	GO:0045638	negative regulation of myeloid cell differentiation	3	68	3.01e-02
GO:BP	GO:0001822	kidney development	2	244	3.03e-02
GO:BP	GO:0061724	lipophagy	1	7	3.03e-02
GO:BP	GO:0002067	glandular epithelial cell differentiation	3	49	3.12e-02
GO:BP	GO:0055013	cardiac muscle cell development	3	70	3.12e-02
GO:BP	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress	1	5	3.12e-02
GO:BP	GO:0003174	mitral valve development	1	11	3.12e-02
GO:BP	GO:1904690	positive regulation of cytoplasmic translational initiation	1	5	3.12e-02
GO:BP	GO:0072001	renal system development	2	250	3.12e-02
GO:BP	GO:1903912	negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	1	5	3.12e-02
GO:BP	GO:0040007	growth	10	736	3.13e-02
GO:BP	GO:2000647	negative regulation of stem cell proliferation	1	18	3.15e-02
GO:BP	GO:0002089	lens morphogenesis in camera-type eye	2	18	3.15e-02
GO:BP	GO:0003228	atrial cardiac muscle tissue development	2	18	3.15e-02
GO:BP	GO:0009743	response to carbohydrate	3	163	3.19e-02
GO:BP	GO:0009950	dorsal/ventral axis specification	1	10	3.19e-02
GO:BP	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation	1	12	3.19e-02
GO:BP	GO:0072331	signal transduction by p53 class mediator	3	160	3.19e-02
GO:BP	GO:0007183	SMAD protein complex assembly	1	12	3.19e-02
GO:BP	GO:1902893	regulation of miRNA transcription	2	51	3.21e-02
GO:BP	GO:0061614	miRNA transcription	2	52	3.26e-02
GO:BP	GO:0003289	atrial septum primum morphogenesis	1	5	3.26e-02
GO:BP	GO:0032331	negative regulation of chondrocyte differentiation	1	18	3.26e-02
GO:BP	GO:0003284	septum primum development	1	5	3.26e-02
GO:BP	GO:0048589	developmental growth	8	516	3.39e-02
GO:BP	GO:0002194	hepatocyte cell migration	1	1	3.39e-02
GO:BP	GO:0043049	otic placode formation	1	1	3.39e-02
GO:BP	GO:1903898	negative regulation of PERK-mediated unfolded protein response	1	6	3.39e-02
GO:BP	GO:1904688	regulation of cytoplasmic translational initiation	1	6	3.39e-02
GO:BP	GO:0061114	branching involved in pancreas morphogenesis	1	1	3.39e-02
GO:BP	GO:2000979	positive regulation of forebrain neuron differentiation	1	1	3.39e-02
GO:BP	GO:2000178	negative regulation of neural precursor cell proliferation	2	21	3.42e-02
GO:BP	GO:0031333	negative regulation of protein-containing complex assembly	2	127	3.42e-02
GO:BP	GO:0055006	cardiac cell development	3	76	3.42e-02
GO:BP	GO:0003416	endochondral bone growth	1	22	3.42e-02
GO:BP	GO:0034616	response to laminar fluid shear stress	1	14	3.42e-02
GO:BP	GO:0035116	embryonic hindlimb morphogenesis	1	17	3.42e-02
GO:BP	GO:1901031	regulation of response to reactive oxygen species	2	29	3.49e-02
GO:BP	GO:0045637	regulation of myeloid cell differentiation	4	151	3.52e-02
GO:BP	GO:1990654	sebum secreting cell proliferation	1	2	3.55e-02
GO:BP	GO:0010660	regulation of muscle cell apoptotic process	2	57	3.55e-02
GO:BP	GO:0031016	pancreas development	3	52	3.55e-02
GO:BP	GO:0061061	muscle structure development	8	543	3.55e-02
GO:BP	GO:0061026	cardiac muscle tissue regeneration	1	6	3.55e-02
GO:BP	GO:0009719	response to endogenous stimulus	5	1258	3.55e-02
GO:BP	GO:0098868	bone growth	1	23	3.63e-02
GO:BP	GO:0061037	negative regulation of cartilage development	1	23	3.63e-02
GO:BP	GO:0036492	eiF2alpha phosphorylation in response to endoplasmic reticulum stress	1	7	3.65e-02
GO:BP	GO:0034605	cellular response to heat	1	51	3.65e-02
GO:BP	GO:0002191	cap-dependent translational initiation	1	7	3.65e-02
GO:BP	GO:0048384	retinoic acid receptor signaling pathway	1	26	3.69e-02
GO:BP	GO:0048566	embryonic digestive tract development	1	20	3.77e-02
GO:BP	GO:0071233	cellular response to leucine	1	10	3.77e-02
GO:BP	GO:0003184	pulmonary valve morphogenesis	1	17	3.79e-02
GO:BP	GO:0043627	response to estrogen	2	51	3.79e-02
GO:BP	GO:0060351	cartilage development involved in endochondral bone morphogenesis	1	25	3.79e-02
GO:BP	GO:0051146	striated muscle cell differentiation	5	231	3.79e-02
GO:BP	GO:0010657	muscle cell apoptotic process	2	60	3.79e-02
GO:BP	GO:2000628	regulation of miRNA metabolic process	2	62	3.79e-02
GO:BP	GO:0048048	embryonic eye morphogenesis	1	25	3.86e-02
GO:BP	GO:0060290	transdifferentiation	1	2	3.86e-02
GO:BP	GO:0035137	hindlimb morphogenesis	1	20	3.86e-02
GO:BP	GO:0032056	positive regulation of translation in response to stress	1	8	3.90e-02
GO:BP	GO:0036491	regulation of translation initiation in response to endoplasmic reticulum stress	1	8	3.90e-02
GO:BP	GO:0007172	signal complex assembly	1	7	3.90e-02
GO:BP	GO:0060043	regulation of cardiac muscle cell proliferation	2	32	3.90e-02
GO:BP	GO:0048523	negative regulation of cellular process	15	3628	3.99e-02
GO:BP	GO:0002068	glandular epithelial cell development	1	28	3.99e-02
GO:BP	GO:0051892	negative regulation of cardioblast differentiation	1	1	4.07e-02
GO:BP	GO:1990253	cellular response to leucine starvation	1	13	4.16e-02
GO:BP	GO:0032665	regulation of interleukin-21 production	1	1	4.16e-02
GO:BP	GO:0032625	interleukin-21 production	1	1	4.16e-02
GO:BP	GO:0060486	club cell differentiation	1	3	4.16e-02
GO:BP	GO:1900101	regulation of endoplasmic reticulum unfolded protein response	2	28	4.16e-02
GO:BP	GO:0003209	cardiac atrium morphogenesis	2	26	4.16e-02
GO:BP	GO:0003190	atrioventricular valve formation	1	8	4.16e-02
GO:BP	GO:0032745	positive regulation of interleukin-21 production	1	1	4.16e-02
GO:BP	GO:0006930	substrate-dependent cell migration, cell extension	1	8	4.19e-02
GO:BP	GO:0080134	regulation of response to stress	7	1084	4.24e-02
GO:BP	GO:0098751	bone cell development	2	26	4.30e-02
GO:BP	GO:0003177	pulmonary valve development	1	20	4.30e-02
GO:BP	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress	1	10	4.56e-02
GO:BP	GO:0043201	response to leucine	1	13	4.56e-02
GO:BP	GO:0048617	embryonic foregut morphogenesis	1	6	4.56e-02
GO:BP	GO:0042127	regulation of cell population proliferation	3	1141	4.68e-02
GO:BP	GO:0007492	endoderm development	2	65	4.68e-02
GO:BP	GO:1902235	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	2	29	4.80e-02
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	3	229	4.82e-02
GO:BP	GO:0060840	artery development	3	82	4.82e-02
GO:BP	GO:0010586	miRNA metabolic process	2	76	4.82e-02
GO:BP	GO:0010998	regulation of translational initiation by eIF2 alpha phosphorylation	1	11	4.87e-02
GO:BP	GO:1903897	regulation of PERK-mediated unfolded protein response	1	10	4.87e-02
GO:BP	GO:0007440	foregut morphogenesis	1	7	4.89e-02
GO:BP	GO:0002066	columnar/cuboidal epithelial cell development	1	38	4.89e-02

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:1903047	mitotic cell cycle process	99	700	1.02e-61
GO:BP	GO:0022402	cell cycle process	117	1075	4.84e-60
GO:BP	GO:0000278	mitotic cell cycle	104	833	4.84e-60
GO:BP	GO:0007049	cell cycle	133	1522	1.01e-58
GO:BP	GO:0007059	chromosome segregation	75	378	9.96e-55
GO:BP	GO:0098813	nuclear chromosome segregation	66	287	7.07e-51
GO:BP	GO:0000280	nuclear division	72	354	9.04e-50
GO:BP	GO:0140014	mitotic nuclear division	61	264	1.43e-48
GO:BP	GO:0051276	chromosome organization	84	543	2.28e-48
GO:BP	GO:0000819	sister chromatid segregation	57	234	1.93e-47
GO:BP	GO:0000070	mitotic sister chromatid segregation	53	193	3.35e-47
GO:BP	GO:0048285	organelle fission	72	397	6.12e-47
GO:BP	GO:0051301	cell division	80	567	6.18e-47
GO:BP	GO:0010564	regulation of cell cycle process	98	620	3.56e-45
GO:BP	GO:0051726	regulation of cell cycle	87	950	7.08e-40
GO:BP	GO:0044770	cell cycle phase transition	76	499	4.59e-34
GO:BP	GO:1901987	regulation of cell cycle phase transition	68	388	3.42e-32
GO:BP	GO:0000075	cell cycle checkpoint signaling	47	180	7.73e-32
GO:BP	GO:0006261	DNA-templated DNA replication	56	149	2.62e-30
GO:BP	GO:0007346	regulation of mitotic cell cycle	69	438	1.54e-29
GO:BP	GO:0044772	mitotic cell cycle phase transition	66	413	2.50e-29
GO:BP	GO:0007093	mitotic cell cycle checkpoint signaling	40	136	2.93e-29
GO:BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	28	156	5.47e-29
GO:BP	GO:0051983	regulation of chromosome segregation	26	118	5.56e-28
GO:BP	GO:1901988	negative regulation of cell cycle phase transition	49	232	6.25e-28
GO:BP	GO:0006260	DNA replication	70	258	7.28e-28
GO:BP	GO:0010948	negative regulation of cell cycle process	52	270	1.34e-27
GO:BP	GO:0007051	spindle organization	26	186	2.38e-27
GO:BP	GO:1901990	regulation of mitotic cell cycle phase transition	55	305	6.02e-27
GO:BP	GO:0090068	positive regulation of cell cycle process	39	206	1.69e-25
GO:BP	GO:0007052	mitotic spindle organization	22	128	2.88e-25
GO:BP	GO:0045930	negative regulation of mitotic cell cycle	44	208	3.93e-25
GO:BP	GO:0045786	negative regulation of cell cycle	55	334	4.10e-25
GO:BP	GO:0000226	microtubule cytoskeleton organization	49	552	5.25e-25
GO:BP	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	22	91	7.33e-25
GO:BP	GO:1905818	regulation of chromosome separation	20	69	8.92e-25
GO:BP	GO:0044784	metaphase/anaphase transition of cell cycle	22	92	1.48e-24
GO:BP	GO:0051304	chromosome separation	20	74	4.79e-24
GO:BP	GO:0033045	regulation of sister chromatid segregation	22	99	9.24e-24
GO:BP	GO:0006974	cellular response to DNA damage stimulus	109	789	1.34e-23
GO:BP	GO:0030071	regulation of mitotic metaphase/anaphase transition	21	88	1.44e-23
GO:BP	GO:0006259	DNA metabolic process	85	890	1.69e-23
GO:BP	GO:1902099	regulation of metaphase/anaphase transition of cell cycle	21	89	2.87e-23
GO:BP	GO:0007088	regulation of mitotic nuclear division	29	100	4.13e-23
GO:BP	GO:0010965	regulation of mitotic sister chromatid separation	18	58	5.60e-23
GO:BP	GO:0051306	mitotic sister chromatid separation	18	61	1.45e-22
GO:BP	GO:1901991	negative regulation of mitotic cell cycle phase transition	33	163	2.04e-22
GO:BP	GO:0045787	positive regulation of cell cycle	41	278	3.32e-22
GO:BP	GO:0033044	regulation of chromosome organization	27	233	1.07e-21
GO:BP	GO:0051783	regulation of nuclear division	29	115	1.16e-21
GO:BP	GO:0007094	mitotic spindle assembly checkpoint signaling	16	44	1.27e-21
GO:BP	GO:0071173	spindle assembly checkpoint signaling	16	44	1.27e-21
GO:BP	GO:0071174	mitotic spindle checkpoint signaling	16	44	1.27e-21
GO:BP	GO:0031577	spindle checkpoint signaling	16	45	1.85e-21
GO:BP	GO:0008608	attachment of spindle microtubules to kinetochore	19	42	2.30e-21
GO:BP	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	16	46	2.64e-21
GO:BP	GO:0033048	negative regulation of mitotic sister chromatid segregation	16	47	5.22e-21
GO:BP	GO:1902100	negative regulation of metaphase/anaphase transition of cell cycle	16	47	5.22e-21
GO:BP	GO:0033046	negative regulation of sister chromatid segregation	16	47	5.22e-21
GO:BP	GO:2000816	negative regulation of mitotic sister chromatid separation	16	47	5.22e-21
GO:BP	GO:0007017	microtubule-based process	41	756	8.17e-21
GO:BP	GO:2001251	negative regulation of chromosome organization	19	90	8.88e-21
GO:BP	GO:0051985	negative regulation of chromosome segregation	16	48	1.00e-20
GO:BP	GO:1905819	negative regulation of chromosome separation	16	48	1.00e-20
GO:BP	GO:0033047	regulation of mitotic sister chromatid segregation	16	52	2.72e-20
GO:BP	GO:0045839	negative regulation of mitotic nuclear division	16	54	3.71e-20
GO:BP	GO:0006281	DNA repair	81	535	5.94e-20
GO:BP	GO:0051784	negative regulation of nuclear division	16	57	2.92e-19
GO:BP	GO:0051225	spindle assembly	18	118	4.37e-19
GO:BP	GO:0051310	metaphase plate congression	20	69	8.69e-19
GO:BP	GO:0031570	DNA integrity checkpoint signaling	29	126	5.46e-18
GO:BP	GO:0050000	chromosome localization	21	82	5.75e-18
GO:BP	GO:0006270	DNA replication initiation	22	35	6.50e-18
GO:BP	GO:0051303	establishment of chromosome localization	20	75	2.32e-17
GO:BP	GO:0006996	organelle organization	92	2971	4.16e-17
GO:BP	GO:0051321	meiotic cell cycle	32	188	1.22e-16
GO:BP	GO:0090307	mitotic spindle assembly	14	69	1.22e-16
GO:BP	GO:0007080	mitotic metaphase plate congression	17	55	1.96e-16
GO:BP	GO:0140694	non-membrane-bounded organelle assembly	23	355	2.02e-16
GO:BP	GO:0090329	regulation of DNA-templated DNA replication	24	54	3.77e-16
GO:BP	GO:0033043	regulation of organelle organization	41	1023	1.36e-15
GO:BP	GO:0044839	cell cycle G2/M phase transition	35	148	1.55e-15
GO:BP	GO:1903046	meiotic cell cycle process	27	136	2.70e-15
GO:BP	GO:0140013	meiotic nuclear division	26	121	2.98e-15
GO:BP	GO:0000086	G2/M transition of mitotic cell cycle	30	134	5.76e-15
GO:BP	GO:0032392	DNA geometric change	29	81	7.20e-15
GO:BP	GO:0032508	DNA duplex unwinding	28	75	8.18e-15
GO:BP	GO:0000077	DNA damage checkpoint signaling	25	118	1.58e-14
GO:BP	GO:0000281	mitotic cytokinesis	14	81	1.97e-14
GO:BP	GO:0007010	cytoskeleton organization	42	1222	2.79e-14
GO:BP	GO:0044774	mitotic DNA integrity checkpoint signaling	21	82	5.71e-14
GO:BP	GO:0042770	signal transduction in response to DNA damage	29	173	6.10e-14
GO:BP	GO:0071103	DNA conformation change	29	88	9.60e-14
GO:BP	GO:0006275	regulation of DNA replication	34	124	1.54e-13
GO:BP	GO:0000910	cytokinesis	21	163	1.94e-13
GO:BP	GO:0033554	cellular response to stress	151	1677	2.01e-13
GO:BP	GO:0044773	mitotic DNA damage checkpoint signaling	20	78	2.74e-13
GO:BP	GO:0045132	meiotic chromosome segregation	19	69	3.04e-13
GO:BP	GO:0051984	positive regulation of chromosome segregation	11	25	6.92e-13
GO:BP	GO:0061640	cytoskeleton-dependent cytokinesis	14	103	9.97e-13
GO:BP	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	11	18	1.77e-12
GO:BP	GO:1901976	regulation of cell cycle checkpoint	13	45	4.46e-12
GO:BP	GO:0051231	spindle elongation	8	12	4.54e-12
GO:BP	GO:0032465	regulation of cytokinesis	19	79	9.88e-12
GO:BP	GO:0044786	cell cycle DNA replication	18	40	1.80e-11
GO:BP	GO:0010389	regulation of G2/M transition of mitotic cell cycle	22	92	1.98e-11
GO:BP	GO:0033260	nuclear DNA replication	17	35	2.15e-11
GO:BP	GO:0010639	negative regulation of organelle organization	20	318	3.79e-11
GO:BP	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	8	21	4.14e-11
GO:BP	GO:0051256	mitotic spindle midzone assembly	7	9	5.90e-11
GO:BP	GO:1905820	positive regulation of chromosome separation	10	26	7.74e-11
GO:BP	GO:1901992	positive regulation of mitotic cell cycle phase transition	19	86	7.87e-11
GO:BP	GO:0006268	DNA unwinding involved in DNA replication	10	22	7.88e-11
GO:BP	GO:1901989	positive regulation of cell cycle phase transition	21	103	7.88e-11
GO:BP	GO:0051656	establishment of organelle localization	22	375	9.91e-11
GO:BP	GO:0000022	mitotic spindle elongation	7	10	1.33e-10
GO:BP	GO:1902749	regulation of cell cycle G2/M phase transition	22	102	1.74e-10
GO:BP	GO:0051302	regulation of cell division	24	144	2.23e-10
GO:BP	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	11	13	2.48e-10
GO:BP	GO:1900262	regulation of DNA-directed DNA polymerase activity	11	13	2.48e-10
GO:BP	GO:0051383	kinetochore organization	9	23	3.31e-10
GO:BP	GO:0051640	organelle localization	24	498	3.41e-10
GO:BP	GO:0045931	positive regulation of mitotic cell cycle	23	113	3.94e-10
GO:BP	GO:0051255	spindle midzone assembly	7	12	5.33e-10
GO:BP	GO:0000727	double-strand break repair via break-induced replication	7	11	5.78e-10
GO:BP	GO:0051052	regulation of DNA metabolic process	39	459	7.41e-10
GO:BP	GO:0006310	DNA recombination	24	256	1.11e-09
GO:BP	GO:0070925	organelle assembly	25	803	1.20e-09
GO:BP	GO:0006302	double-strand break repair	23	270	1.30e-09
GO:BP	GO:0034502	protein localization to chromosome	26	110	1.38e-09
GO:BP	GO:0061982	meiosis I cell cycle process	17	80	2.59e-09
GO:BP	GO:1902969	mitotic DNA replication	10	14	2.67e-09
GO:BP	GO:0065004	protein-DNA complex assembly	31	185	2.72e-09
GO:BP	GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint	7	19	3.51e-09
GO:BP	GO:0090231	regulation of spindle checkpoint	7	19	3.51e-09
GO:BP	GO:1903504	regulation of mitotic spindle checkpoint	7	19	3.51e-09
GO:BP	GO:0030174	regulation of DNA-templated DNA replication initiation	7	14	4.17e-09
GO:BP	GO:0051128	regulation of cellular component organization	37	1947	6.86e-09
GO:BP	GO:0034508	centromere complex assembly	16	30	7.37e-09
GO:BP	GO:0032467	positive regulation of cytokinesis	12	33	7.86e-09
GO:BP	GO:0007127	meiosis I	16	76	1.17e-08
GO:BP	GO:0071824	protein-DNA complex subunit organization	20	204	1.23e-08
GO:BP	GO:0030261	chromosome condensation	10	34	1.52e-08
GO:BP	GO:0000724	double-strand break repair via homologous recombination	20	147	1.72e-08
GO:BP	GO:0090224	regulation of spindle organization	10	45	1.86e-08
GO:BP	GO:0071459	protein localization to chromosome, centromeric region	11	42	2.28e-08
GO:BP	GO:0051653	spindle localization	9	52	2.35e-08
GO:BP	GO:0000725	recombinational repair	20	151	2.55e-08
GO:BP	GO:0007062	sister chromatid cohesion	11	51	4.52e-08
GO:BP	GO:0051129	negative regulation of cellular component organization	22	586	8.09e-08
GO:BP	GO:0007143	female meiotic nuclear division	6	25	8.54e-08
GO:BP	GO:1901970	positive regulation of mitotic sister chromatid separation	6	18	9.99e-08
GO:BP	GO:0010212	response to ionizing radiation	28	130	1.11e-07
GO:BP	GO:1901978	positive regulation of cell cycle checkpoint	6	19	1.12e-07
GO:BP	GO:0060236	regulation of mitotic spindle organization	9	42	1.65e-07
GO:BP	GO:0051293	establishment of spindle localization	8	48	2.87e-07
GO:BP	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	13	87	3.53e-07
GO:BP	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	10	60	3.98e-07
GO:BP	GO:1904029	regulation of cyclin-dependent protein kinase activity	13	90	4.82e-07
GO:BP	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	5	12	4.95e-07
GO:BP	GO:0090232	positive regulation of spindle checkpoint	5	12	4.95e-07
GO:BP	GO:1902750	negative regulation of cell cycle G2/M phase transition	10	62	5.32e-07
GO:BP	GO:0000076	DNA replication checkpoint signaling	9	15	5.39e-07
GO:BP	GO:0071897	DNA biosynthetic process	31	175	5.53e-07
GO:BP	GO:0034501	protein localization to kinetochore	7	18	5.70e-07
GO:BP	GO:1903083	protein localization to condensed chromosome	7	18	5.70e-07
GO:BP	GO:0007095	mitotic G2 DNA damage checkpoint signaling	8	35	5.93e-07
GO:BP	GO:0006271	DNA strand elongation involved in DNA replication	9	15	6.02e-07
GO:BP	GO:0040001	establishment of mitotic spindle localization	7	36	6.27e-07
GO:BP	GO:0044818	mitotic G2/M transition checkpoint	9	50	7.99e-07
GO:BP	GO:0071479	cellular response to ionizing radiation	11	68	8.20e-07
GO:BP	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	9	27	8.22e-07
GO:BP	GO:0007098	centrosome cycle	13	126	1.17e-06
GO:BP	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore	6	11	1.67e-06
GO:BP	GO:1902751	positive regulation of cell cycle G2/M phase transition	9	30	2.20e-06
GO:BP	GO:0008315	G2/MI transition of meiotic cell cycle	5	5	2.63e-06
GO:BP	GO:0007076	mitotic chromosome condensation	6	19	3.00e-06
GO:BP	GO:0031023	microtubule organizing center organization	13	136	3.38e-06
GO:BP	GO:0070507	regulation of microtubule cytoskeleton organization	13	146	3.42e-06
GO:BP	GO:0045005	DNA-templated DNA replication maintenance of fidelity	12	50	3.42e-06
GO:BP	GO:1903490	positive regulation of mitotic cytokinesis	5	7	3.65e-06
GO:BP	GO:0044771	meiotic cell cycle phase transition	6	7	4.53e-06
GO:BP	GO:0051382	kinetochore assembly	4	18	4.95e-06
GO:BP	GO:0070192	chromosome organization involved in meiotic cell cycle	10	44	5.50e-06
GO:BP	GO:0090235	regulation of metaphase plate congression	6	13	5.62e-06
GO:BP	GO:0032506	cytokinetic process	8	39	6.94e-06
GO:BP	GO:0044843	cell cycle G1/S phase transition	32	225	8.02e-06
GO:BP	GO:1902425	positive regulation of attachment of mitotic spindle microtubules to kinetochore	5	8	9.15e-06
GO:BP	GO:1902423	regulation of attachment of mitotic spindle microtubules to kinetochore	5	8	9.15e-06
GO:BP	GO:1902292	cell cycle DNA replication initiation	5	5	9.31e-06
GO:BP	GO:1902975	mitotic DNA replication initiation	5	5	9.31e-06
GO:BP	GO:1902315	nuclear cell cycle DNA replication initiation	5	5	9.31e-06
GO:BP	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	14	43	9.55e-06
GO:BP	GO:0000212	meiotic spindle organization	4	14	1.60e-05
GO:BP	GO:0000082	G1/S transition of mitotic cell cycle	29	203	1.63e-05
GO:BP	GO:0010332	response to gamma radiation	14	50	1.70e-05
GO:BP	GO:0051294	establishment of spindle orientation	6	36	1.83e-05
GO:BP	GO:0072331	signal transduction by p53 class mediator	29	160	1.83e-05
GO:BP	GO:0051338	regulation of transferase activity	35	713	2.59e-05
GO:BP	GO:0051781	positive regulation of cell division	9	64	2.73e-05
GO:BP	GO:0009314	response to radiation	45	349	2.73e-05
GO:BP	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	23	76	2.73e-05
GO:BP	GO:0016321	female meiosis chromosome segregation	3	5	2.97e-05
GO:BP	GO:1902412	regulation of mitotic cytokinesis	5	8	3.68e-05
GO:BP	GO:0031297	replication fork processing	10	42	3.92e-05
GO:BP	GO:1903934	positive regulation of DNA primase activity	5	5	4.21e-05
GO:BP	GO:1903932	regulation of DNA primase activity	5	5	4.21e-05
GO:BP	GO:2000001	regulation of DNA damage checkpoint	6	25	4.84e-05
GO:BP	GO:0071478	cellular response to radiation	14	155	4.88e-05
GO:BP	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	6	15	5.07e-05
GO:BP	GO:0031571	mitotic G1 DNA damage checkpoint signaling	9	27	5.44e-05
GO:BP	GO:0032886	regulation of microtubule-based process	15	217	5.87e-05
GO:BP	GO:0007292	female gamete generation	7	104	5.87e-05
GO:BP	GO:1905832	positive regulation of spindle assembly	5	7	6.32e-05
GO:BP	GO:0035825	homologous recombination	8	43	7.06e-05
GO:BP	GO:0044819	mitotic G1/S transition checkpoint signaling	9	27	7.32e-05
GO:BP	GO:0000132	establishment of mitotic spindle orientation	7	31	8.73e-05
GO:BP	GO:1905821	positive regulation of chromosome condensation	5	5	9.48e-05
GO:BP	GO:0051307	meiotic chromosome separation	3	5	1.16e-04
GO:BP	GO:0007018	microtubule-based movement	11	296	1.20e-04
GO:BP	GO:0044260	cellular macromolecule metabolic process	105	2777	1.20e-04
GO:BP	GO:0090306	meiotic spindle assembly	3	8	1.20e-04
GO:BP	GO:0071168	protein localization to chromatin	12	49	1.20e-04
GO:BP	GO:0090169	regulation of spindle assembly	6	32	1.34e-04
GO:BP	GO:0030330	DNA damage response, signal transduction by p53 class mediator	10	68	1.34e-04
GO:BP	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	7	16	1.37e-04
GO:BP	GO:0035556	intracellular signal transduction	51	2065	1.60e-04
GO:BP	GO:0036297	interstrand cross-link repair	7	37	1.76e-04
GO:BP	GO:0051053	negative regulation of DNA metabolic process	14	118	2.01e-04
GO:BP	GO:0000731	DNA synthesis involved in DNA repair	11	36	2.38e-04
GO:BP	GO:1904668	positive regulation of ubiquitin protein ligase activity	3	11	2.49e-04
GO:BP	GO:0099607	lateral attachment of mitotic spindle microtubules to kinetochore	2	2	2.54e-04
GO:BP	GO:0007144	female meiosis I	5	9	2.71e-04
GO:BP	GO:0006513	protein monoubiquitination	12	83	2.81e-04
GO:BP	GO:0140527	reciprocal homologous recombination	7	36	2.81e-04
GO:BP	GO:0007131	reciprocal meiotic recombination	7	36	2.81e-04
GO:BP	GO:2000104	negative regulation of DNA-templated DNA replication	5	14	2.87e-04
GO:BP	GO:0007057	spindle assembly involved in female meiosis I	4	4	2.89e-04
GO:BP	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	5	17	2.93e-04
GO:BP	GO:2000045	regulation of G1/S transition of mitotic cell cycle	21	146	3.35e-04
GO:BP	GO:0070601	centromeric sister chromatid cohesion	3	11	3.46e-04
GO:BP	GO:0042772	DNA damage response, signal transduction resulting in transcription	5	18	3.87e-04
GO:BP	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	19	94	3.92e-04
GO:BP	GO:1902806	regulation of cell cycle G1/S phase transition	23	166	4.06e-04
GO:BP	GO:0007079	mitotic chromosome movement towards spindle pole	2	4	4.09e-04
GO:BP	GO:0051054	positive regulation of DNA metabolic process	19	261	4.46e-04
GO:BP	GO:0010032	meiotic chromosome condensation	5	6	4.70e-04
GO:BP	GO:0009411	response to UV	22	137	4.84e-04
GO:BP	GO:0110032	positive regulation of G2/MI transition of meiotic cell cycle	3	3	4.92e-04
GO:BP	GO:0022616	DNA strand elongation	10	35	5.32e-04
GO:BP	GO:0051177	meiotic sister chromatid cohesion	3	11	5.45e-04
GO:BP	GO:0045144	meiotic sister chromatid segregation	3	11	5.45e-04
GO:BP	GO:0001932	regulation of protein phosphorylation	34	815	5.71e-04
GO:BP	GO:0051298	centrosome duplication	12	68	5.82e-04
GO:BP	GO:0061983	meiosis II cell cycle process	3	12	6.69e-04
GO:BP	GO:0007135	meiosis II	3	12	6.69e-04
GO:BP	GO:0006468	protein phosphorylation	43	1183	7.45e-04
GO:BP	GO:0051754	meiotic sister chromatid cohesion, centromeric	3	4	8.76e-04
GO:BP	GO:0022414	reproductive process	32	924	9.05e-04
GO:BP	GO:1904666	regulation of ubiquitin protein ligase activity	4	24	9.43e-04
GO:BP	GO:0051445	regulation of meiotic cell cycle	9	45	9.58e-04
GO:BP	GO:0008156	negative regulation of DNA replication	6	26	9.91e-04
GO:BP	GO:0000003	reproduction	32	931	1.00e-03
GO:BP	GO:0006325	chromatin organization	55	536	1.01e-03
GO:BP	GO:0033314	mitotic DNA replication checkpoint signaling	5	9	1.02e-03
GO:BP	GO:1902117	positive regulation of organelle assembly	14	75	1.08e-03
GO:BP	GO:0045143	homologous chromosome segregation	7	33	1.13e-03
GO:BP	GO:0042325	regulation of phosphorylation	36	932	1.19e-03
GO:BP	GO:0031399	regulation of protein modification process	16	1207	1.22e-03
GO:BP	GO:0051438	regulation of ubiquitin-protein transferase activity	4	53	1.24e-03
GO:BP	GO:0071480	cellular response to gamma radiation	5	29	1.24e-03
GO:BP	GO:0031109	microtubule polymerization or depolymerization	7	117	1.28e-03
GO:BP	GO:0051305	chromosome movement towards spindle pole	2	7	1.28e-03
GO:BP	GO:1901993	regulation of meiotic cell cycle phase transition	4	5	1.29e-03
GO:BP	GO:0034080	CENP-A containing chromatin assembly	5	7	1.33e-03
GO:BP	GO:0031055	chromatin remodeling at centromere	5	7	1.33e-03
GO:BP	GO:2000573	positive regulation of DNA biosynthetic process	8	67	1.40e-03
GO:BP	GO:0045910	negative regulation of DNA recombination	7	31	1.42e-03
GO:BP	GO:0110030	regulation of G2/MI transition of meiotic cell cycle	3	3	1.72e-03
GO:BP	GO:1901995	positive regulation of meiotic cell cycle phase transition	3	3	1.72e-03
GO:BP	GO:2000278	regulation of DNA biosynthetic process	11	111	1.77e-03
GO:BP	GO:0000915	actomyosin contractile ring assembly	3	6	1.83e-03
GO:BP	GO:0000912	assembly of actomyosin apparatus involved in cytokinesis	3	6	1.83e-03
GO:BP	GO:0010390	histone monoubiquitination	7	35	1.84e-03
GO:BP	GO:0007056	spindle assembly involved in female meiosis	3	5	1.87e-03
GO:BP	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	13	61	1.90e-03
GO:BP	GO:0007064	mitotic sister chromatid cohesion	5	29	2.07e-03
GO:BP	GO:0031145	anaphase-promoting complex-dependent catabolic process	3	23	2.28e-03
GO:BP	GO:0007099	centriole replication	10	38	2.38e-03
GO:BP	GO:0051493	regulation of cytoskeleton organization	19	457	2.42e-03
GO:BP	GO:0006334	nucleosome assembly	12	80	2.79e-03
GO:BP	GO:1905784	regulation of anaphase-promoting complex-dependent catabolic process	2	4	2.80e-03
GO:BP	GO:0010638	positive regulation of organelle organization	18	432	3.00e-03
GO:BP	GO:1902298	cell cycle DNA replication maintenance of fidelity	2	2	3.02e-03
GO:BP	GO:1990505	mitotic DNA replication maintenance of fidelity	2	2	3.02e-03
GO:BP	GO:0044837	actomyosin contractile ring organization	3	7	3.02e-03
GO:BP	GO:0046601	positive regulation of centriole replication	4	9	3.02e-03
GO:BP	GO:1990426	mitotic recombination-dependent replication fork processing	2	2	3.02e-03
GO:BP	GO:0051347	positive regulation of transferase activity	11	437	3.02e-03
GO:BP	GO:0104004	cellular response to environmental stimulus	17	264	3.14e-03
GO:BP	GO:0071214	cellular response to abiotic stimulus	17	264	3.14e-03
GO:BP	GO:0045842	positive regulation of mitotic metaphase/anaphase transition	3	14	3.14e-03
GO:BP	GO:0071900	regulation of protein serine/threonine kinase activity	16	302	3.25e-03
GO:BP	GO:0060623	regulation of chromosome condensation	4	9	3.25e-03
GO:BP	GO:0071163	DNA replication preinitiation complex assembly	2	3	3.26e-03
GO:BP	GO:0032201	telomere maintenance via semi-conservative replication	4	8	3.34e-03
GO:BP	GO:1902410	mitotic cytokinetic process	4	23	3.43e-03
GO:BP	GO:0043137	DNA replication, removal of RNA primer	3	4	3.52e-03
GO:BP	GO:1904776	regulation of protein localization to cell cortex	3	8	3.57e-03
GO:BP	GO:1905463	negative regulation of DNA duplex unwinding	2	4	3.59e-03
GO:BP	GO:1902101	positive regulation of metaphase/anaphase transition of cell cycle	3	14	3.73e-03
GO:BP	GO:1903925	response to bisphenol A	3	4	4.18e-03
GO:BP	GO:0016310	phosphorylation	19	1443	4.18e-03
GO:BP	GO:1903926	cellular response to bisphenol A	3	4	4.18e-03
GO:BP	GO:1902115	regulation of organelle assembly	20	186	4.18e-03
GO:BP	GO:0046599	regulation of centriole replication	6	21	4.24e-03
GO:BP	GO:0097193	intrinsic apoptotic signaling pathway	20	260	4.26e-03
GO:BP	GO:0051443	positive regulation of ubiquitin-protein transferase activity	3	29	4.26e-03
GO:BP	GO:0045859	regulation of protein kinase activity	22	512	4.41e-03
GO:BP	GO:0000018	regulation of DNA recombination	11	101	4.42e-03
GO:BP	GO:0085020	protein K6-linked ubiquitination	4	9	4.48e-03
GO:BP	GO:0061952	midbody abscission	3	17	4.69e-03
GO:BP	GO:0098534	centriole assembly	10	41	4.79e-03
GO:BP	GO:0035518	histone H2A monoubiquitination	4	23	4.81e-03
GO:BP	GO:0006566	threonine metabolic process	3	7	5.06e-03
GO:BP	GO:1902807	negative regulation of cell cycle G1/S phase transition	13	67	5.14e-03
GO:BP	GO:0051785	positive regulation of nuclear division	5	37	5.17e-03
GO:BP	GO:0086016	AV node cell action potential	4	9	5.17e-03
GO:BP	GO:0086027	AV node cell to bundle of His cell signaling	4	9	5.17e-03
GO:BP	GO:0006297	nucleotide-excision repair, DNA gap filling	4	5	5.18e-03
GO:BP	GO:0071364	cellular response to epidermal growth factor stimulus	5	41	5.21e-03
GO:BP	GO:0045840	positive regulation of mitotic nuclear division	4	29	5.25e-03
GO:BP	GO:0001934	positive regulation of protein phosphorylation	12	518	5.52e-03
GO:BP	GO:0031401	positive regulation of protein modification process	13	743	5.57e-03
GO:BP	GO:1905340	regulation of protein localization to kinetochore	2	4	5.90e-03
GO:BP	GO:1905342	positive regulation of protein localization to kinetochore	2	4	5.90e-03
GO:BP	GO:2001021	negative regulation of response to DNA damage stimulus	14	76	6.03e-03
GO:BP	GO:2001020	regulation of response to DNA damage stimulus	17	292	6.17e-03
GO:BP	GO:0072697	protein localization to cell cortex	3	10	6.27e-03
GO:BP	GO:1901673	regulation of mitotic spindle assembly	3	23	6.27e-03
GO:BP	GO:0051865	protein autoubiquitination	8	74	6.54e-03
GO:BP	GO:2001252	positive regulation of chromosome organization	13	98	6.54e-03
GO:BP	GO:0018107	peptidyl-threonine phosphorylation	17	97	6.60e-03
GO:BP	GO:1901563	response to camptothecin	3	5	6.91e-03
GO:BP	GO:0006335	DNA replication-dependent chromatin assembly	3	6	7.05e-03
GO:BP	GO:1902808	positive regulation of cell cycle G1/S phase transition	7	52	7.15e-03
GO:BP	GO:0007089	traversing start control point of mitotic cell cycle	3	4	7.41e-03
GO:BP	GO:0070849	response to epidermal growth factor	5	44	7.57e-03
GO:BP	GO:0032042	mitochondrial DNA metabolic process	5	23	7.70e-03
GO:BP	GO:0000921	septin ring assembly	1	1	7.73e-03
GO:BP	GO:0010824	regulation of centrosome duplication	8	44	7.99e-03
GO:BP	GO:0019220	regulation of phosphate metabolic process	38	1044	8.21e-03
GO:BP	GO:0048239	negative regulation of DNA recombination at telomere	2	2	8.21e-03
GO:BP	GO:0072695	regulation of DNA recombination at telomere	2	2	8.21e-03
GO:BP	GO:0051782	negative regulation of cell division	4	15	8.21e-03
GO:BP	GO:0051174	regulation of phosphorus metabolic process	38	1045	8.25e-03
GO:BP	GO:0051444	negative regulation of ubiquitin-protein transferase activity	4	21	8.30e-03
GO:BP	GO:0018210	peptidyl-threonine modification	19	103	8.30e-03
GO:BP	GO:0072719	cellular response to cisplatin	3	4	8.33e-03
GO:BP	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	6	42	8.56e-03
GO:BP	GO:0070194	synaptonemal complex disassembly	1	2	8.99e-03
GO:BP	GO:0034728	nucleosome organization	12	98	9.20e-03
GO:BP	GO:0007019	microtubule depolymerization	4	43	9.50e-03
GO:BP	GO:0006301	postreplication repair	7	34	9.55e-03
GO:BP	GO:0035494	SNARE complex disassembly	3	3	9.75e-03
GO:BP	GO:0007096	regulation of exit from mitosis	4	17	1.01e-02
GO:BP	GO:0006290	pyrimidine dimer repair	1	7	1.03e-02
GO:BP	GO:0086067	AV node cell to bundle of His cell communication	4	11	1.03e-02
GO:BP	GO:0006338	chromatin remodeling	33	309	1.04e-02
GO:BP	GO:1905462	regulation of DNA duplex unwinding	2	7	1.04e-02
GO:BP	GO:0010165	response to X-ray	4	29	1.04e-02
GO:BP	GO:0071139	resolution of recombination intermediates	4	6	1.07e-02
GO:BP	GO:0006269	DNA replication, synthesis of RNA primer	4	6	1.07e-02
GO:BP	GO:1905448	positive regulation of mitochondrial ATP synthesis coupled electron transport	2	4	1.17e-02
GO:BP	GO:0042327	positive regulation of phosphorylation	12	577	1.19e-02
GO:BP	GO:0042148	strand invasion	2	5	1.22e-02
GO:BP	GO:0001833	inner cell mass cell proliferation	6	14	1.22e-02
GO:BP	GO:1900060	negative regulation of ceramide biosynthetic process	3	5	1.23e-02
GO:BP	GO:0090737	telomere maintenance via telomere trimming	4	13	1.23e-02
GO:BP	GO:0001325	formation of extrachromosomal circular DNA	4	13	1.23e-02
GO:BP	GO:0090656	t-circle formation	4	13	1.23e-02
GO:BP	GO:0045740	positive regulation of DNA replication	10	37	1.23e-02
GO:BP	GO:0046605	regulation of centrosome cycle	10	51	1.28e-02
GO:BP	GO:0048478	replication fork protection	3	9	1.28e-02
GO:BP	GO:0030010	establishment of cell polarity	8	131	1.30e-02
GO:BP	GO:0043549	regulation of kinase activity	23	598	1.32e-02
GO:BP	GO:0032954	regulation of cytokinetic process	2	3	1.34e-02
GO:BP	GO:1904031	positive regulation of cyclin-dependent protein kinase activity	4	35	1.34e-02
GO:BP	GO:0051642	centrosome localization	4	31	1.34e-02
GO:BP	GO:0061842	microtubule organizing center localization	4	31	1.34e-02
GO:BP	GO:0034421	post-translational protein acetylation	2	3	1.37e-02
GO:BP	GO:1904172	positive regulation of bleb assembly	1	1	1.37e-02
GO:BP	GO:0031106	septin ring organization	1	2	1.37e-02
GO:BP	GO:1904170	regulation of bleb assembly	1	1	1.37e-02
GO:BP	GO:0048146	positive regulation of fibroblast proliferation	4	45	1.42e-02
GO:BP	GO:0046602	regulation of mitotic centrosome separation	2	8	1.43e-02
GO:BP	GO:0033522	histone H2A ubiquitination	4	32	1.45e-02
GO:BP	GO:0002227	innate immune response in mucosa	5	8	1.45e-02
GO:BP	GO:0050790	regulation of catalytic activity	56	1783	1.49e-02
GO:BP	GO:0072757	cellular response to camptothecin	2	4	1.51e-02
GO:BP	GO:0001556	oocyte maturation	7	23	1.53e-02
GO:BP	GO:0022412	cellular process involved in reproduction in multicellular organism	7	248	1.63e-02
GO:BP	GO:0016574	histone ubiquitination	7	51	1.66e-02
GO:BP	GO:0034644	cellular response to UV	4	83	1.67e-02
GO:BP	GO:1903671	negative regulation of sprouting angiogenesis	3	11	1.67e-02
GO:BP	GO:0062033	positive regulation of mitotic sister chromatid segregation	2	6	1.69e-02
GO:BP	GO:0009265	2’-deoxyribonucleotide biosynthetic process	4	15	1.71e-02
GO:BP	GO:0009263	deoxyribonucleotide biosynthetic process	4	15	1.71e-02
GO:BP	GO:0046385	deoxyribose phosphate biosynthetic process	4	15	1.71e-02
GO:BP	GO:0070914	UV-damage excision repair	1	13	1.72e-02
GO:BP	GO:0072718	response to cisplatin	3	5	1.76e-02
GO:BP	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	7	22	1.82e-02
GO:BP	GO:0071312	cellular response to alkaloid	8	29	1.87e-02
GO:BP	GO:0016446	somatic hypermutation of immunoglobulin genes	4	11	1.87e-02
GO:BP	GO:0031536	positive regulation of exit from mitosis	2	4	2.10e-02
GO:BP	GO:0090155	negative regulation of sphingolipid biosynthetic process	3	6	2.16e-02
GO:BP	GO:0072711	cellular response to hydroxyurea	4	10	2.21e-02
GO:BP	GO:0034198	cellular response to amino acid starvation	6	48	2.23e-02
GO:BP	GO:0007063	regulation of sister chromatid cohesion	3	20	2.30e-02
GO:BP	GO:0010458	exit from mitosis	2	29	2.36e-02
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	11	630	2.41e-02
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	11	630	2.41e-02
GO:BP	GO:0006541	glutamine metabolic process	6	23	2.41e-02
GO:BP	GO:0099606	microtubule plus-end directed mitotic chromosome migration	1	1	2.42e-02
GO:BP	GO:0006903	vesicle targeting	11	61	2.49e-02
GO:BP	GO:0010216	maintenance of DNA methylation	3	7	2.50e-02
GO:BP	GO:0007163	establishment or maintenance of cell polarity	7	203	2.50e-02
GO:BP	GO:1905446	regulation of mitochondrial ATP synthesis coupled electron transport	2	6	2.52e-02
GO:BP	GO:0032185	septin cytoskeleton organization	1	4	2.52e-02
GO:BP	GO:0002566	somatic diversification of immune receptors via somatic mutation	4	12	2.52e-02
GO:BP	GO:0000002	mitochondrial genome maintenance	5	30	2.62e-02
GO:BP	GO:0007077	mitotic nuclear membrane disassembly	1	7	2.63e-02
GO:BP	GO:1990928	response to amino acid starvation	6	50	2.66e-02
GO:BP	GO:0010457	centriole-centriole cohesion	2	14	2.67e-02
GO:BP	GO:2000786	positive regulation of autophagosome assembly	5	19	2.79e-02
GO:BP	GO:0072710	response to hydroxyurea	3	11	2.83e-02
GO:BP	GO:0098910	regulation of atrial cardiac muscle cell action potential	3	4	2.84e-02
GO:BP	GO:0006282	regulation of DNA repair	17	197	3.00e-02
GO:BP	GO:0016043	cellular component organization	100	5016	3.08e-02
GO:BP	GO:2000303	regulation of ceramide biosynthetic process	4	11	3.10e-02
GO:BP	GO:0007100	mitotic centrosome separation	2	13	3.19e-02
GO:BP	GO:0099022	vesicle tethering	7	31	3.19e-02
GO:BP	GO:1904355	positive regulation of telomere capping	2	14	3.36e-02
GO:BP	GO:0001578	microtubule bundle formation	4	79	3.36e-02
GO:BP	GO:0051309	female meiosis chromosome separation	1	2	3.40e-02
GO:BP	GO:2000105	positive regulation of DNA-templated DNA replication	4	14	3.50e-02
GO:BP	GO:0043687	post-translational protein modification	9	64	3.61e-02
GO:BP	GO:0051299	centrosome separation	2	14	3.62e-02
GO:BP	GO:0051661	maintenance of centrosome location	2	6	3.64e-02
GO:BP	GO:1904975	response to bleomycin	2	2	3.64e-02
GO:BP	GO:1904976	cellular response to bleomycin	2	2	3.64e-02
GO:BP	GO:0045007	depurination	1	4	3.83e-02
GO:BP	GO:0006287	base-excision repair, gap-filling	5	14	3.86e-02
GO:BP	GO:1990918	double-strand break repair involved in meiotic recombination	2	2	3.87e-02
GO:BP	GO:0051081	nuclear membrane disassembly	1	11	3.92e-02
GO:BP	GO:0016202	regulation of striated muscle tissue development	1	13	4.02e-02
GO:BP	GO:0036111	very long-chain fatty-acyl-CoA metabolic process	1	2	4.02e-02
GO:BP	GO:0090153	regulation of sphingolipid biosynthetic process	4	12	4.12e-02
GO:BP	GO:0090521	podocyte cell migration	1	7	4.12e-02
GO:BP	GO:1905038	regulation of membrane lipid metabolic process	4	12	4.12e-02
GO:BP	GO:0006312	mitotic recombination	4	23	4.16e-02
GO:BP	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	6	25	4.17e-02
GO:BP	GO:0030397	membrane disassembly	1	12	4.20e-02
GO:BP	GO:1903416	response to glycoside	2	6	4.21e-02
GO:BP	GO:0044090	positive regulation of vacuole organization	5	21	4.21e-02
GO:BP	GO:0019985	translesion synthesis	7	24	4.21e-02
GO:BP	GO:0072698	protein localization to microtubule cytoskeleton	4	52	4.41e-02
GO:BP	GO:1905115	regulation of lateral attachment of mitotic spindle microtubules to kinetochore	1	1	4.49e-02
GO:BP	GO:1905116	positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore	1	1	4.49e-02
GO:BP	GO:0090435	protein localization to nuclear envelope	1	13	4.49e-02
GO:BP	GO:0045004	DNA replication proofreading	2	2	4.54e-02
GO:BP	GO:0051446	positive regulation of meiotic cell cycle	6	15	4.64e-02
GO:BP	GO:0000722	telomere maintenance via recombination	3	15	4.64e-02
GO:BP	GO:0051664	nuclear pore localization	3	4	4.81e-02
GO:BP	GO:0071482	cellular response to light stimulus	4	96	4.89e-02
GO:BP	GO:0044806	G-quadruplex DNA unwinding	3	7	4.94e-02
GO:BP	GO:0021685	cerebellar granular layer structural organization	1	1	4.98e-02
GO:BP	GO:0048634	regulation of muscle organ development	1	14	4.98e-02
KEGG	KEGG:04110	Cell cycle	27	121	6.46e-22
KEGG	KEGG:03030	DNA replication	17	35	3.55e-13
KEGG	KEGG:04115	p53 signaling pathway	23	65	8.00e-12
KEGG	KEGG:03460	Fanconi anemia pathway	10	48	1.45e-06
KEGG	KEGG:03440	Homologous recombination	9	39	1.72e-05
KEGG	KEGG:04114	Oocyte meiosis	9	108	2.47e-05
KEGG	KEGG:04914	Progesterone-mediated oocyte maturation	10	86	7.09e-05
KEGG	KEGG:04218	Cellular senescence	12	145	7.40e-05
KEGG	KEGG:03430	Mismatch repair	8	22	7.40e-05
KEGG	KEGG:03420	Nucleotide excision repair	8	43	1.34e-03
KEGG	KEGG:03410	Base excision repair	10	33	7.77e-03
KEGG	KEGG:05212	Pancreatic cancer	6	75	8.28e-03
KEGG	KEGG:01524	Platinum drug resistance	6	65	1.21e-02
KEGG	KEGG:05166	Human T-cell leukemia virus 1 infection	6	180	1.61e-02
KEGG	KEGG:05322	Systemic lupus erythematosus	3	61	2.75e-02
KEGG	KEGG:04068	FoxO signaling pathway	7	109	4.76e-02
KEGG	KEGG:05216	Thyroid cancer	1	35	4.84e-02
KEGG	KEGG:05203	Viral carcinogenesis	19	172	4.84e-02

AT 3 hours, the Mitoxantrone DEGs, adj. p value < 0.01, look similar to daunorubicin gene sets a 3 hours. hmmm

Venn Diagrams

All DEGs adj p value < 0.05, 24 hour

[1] 8161

All DEGs adj p value < 0.05, 3 hour

[1] 579

Because the 3 hour DEGs are low (expecially in Doxorubicin), we have chosen to focus on analyzing the 24 hour DEGs for GO: BP analysis ### Venn 3 and 24 hour sigDEGs by treatment (adj. p value <0.01) similarities

GO analysis on 24 hour Venn, adj. p value < 0.05

[1] "Number of AC drug DEG genes in common"

[1] 5155

[1] "Number of Doxorubicin specifi DEGs, adj. P value < 0.05"

[1] 342

[1] "Number of All genes that respond to some condition in DEG set, adj. P value  < 0.05"

[1] 8357

[1] "Number of No response genes in DEG set, adj. P value  < 0.05"

[1] 5727

DDE response set

adj. P value < 0.05, intersection of Dauno-Doxo-Epi, excluding those in common with Mitoxantrone n= 4915

no significant enrichment found I did the intersection of all AC drugs and found a list that was 6129 genes long. Below is that analysis.

of the AC genes that overlapped without Mito (n=4178) and all AC gens plus those which overlapped with Mito (n=5155), the significantly enriched GO: BP terms are the same. This may lend the idea that the specific AC set can tell us more about mechanism in AC induced cardiotoxicity.

DDEM response of 977

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:1903047	mitotic cell cycle process	159	700	2.42e-34
GO:BP	GO:0000278	mitotic cell cycle	177	833	2.42e-34
GO:BP	GO:0022402	cell cycle process	202	1075	2.53e-28
GO:BP	GO:0007049	cell cycle	255	1522	3.47e-28
GO:BP	GO:0007059	chromosome segregation	100	378	1.23e-27
GO:BP	GO:0000070	mitotic sister chromatid segregation	67	193	2.14e-27
GO:BP	GO:0000819	sister chromatid segregation	74	234	4.84e-26
GO:BP	GO:0140014	mitotic nuclear division	78	264	1.71e-25
GO:BP	GO:0051301	cell division	120	567	2.02e-25
GO:BP	GO:0051276	chromosome organization	125	543	4.50e-25
GO:BP	GO:0010564	regulation of cell cycle process	130	620	9.24e-23
GO:BP	GO:0098813	nuclear chromosome segregation	83	287	2.38e-22
GO:BP	GO:0000280	nuclear division	93	354	5.07e-22
GO:BP	GO:0007093	mitotic cell cycle checkpoint signaling	51	136	2.68e-21
GO:BP	GO:0000075	cell cycle checkpoint signaling	59	180	3.46e-21
GO:BP	GO:0051726	regulation of cell cycle	168	950	1.80e-20
GO:BP	GO:0048285	organelle fission	93	397	5.54e-19
GO:BP	GO:0006260	DNA replication	70	258	7.22e-19
GO:BP	GO:0051983	regulation of chromosome segregation	45	118	1.76e-18
GO:BP	GO:0006261	DNA-templated DNA replication	51	149	1.76e-18
GO:BP	GO:0044772	mitotic cell cycle phase transition	90	413	3.57e-18
GO:BP	GO:1905818	regulation of chromosome separation	34	69	7.74e-18
GO:BP	GO:0045930	negative regulation of mitotic cell cycle	60	208	8.00e-18
GO:BP	GO:0044770	cell cycle phase transition	101	499	1.64e-17
GO:BP	GO:1901988	negative regulation of cell cycle phase transition	63	232	3.49e-17
GO:BP	GO:0007346	regulation of mitotic cell cycle	92	438	7.93e-17
GO:BP	GO:1901990	regulation of mitotic cell cycle phase transition	72	305	1.28e-16
GO:BP	GO:0051304	chromosome separation	34	74	1.28e-16
GO:BP	GO:0010948	negative regulation of cell cycle process	68	270	1.28e-16
GO:BP	GO:1901987	regulation of cell cycle phase transition	84	388	2.24e-16
GO:BP	GO:2000816	negative regulation of mitotic sister chromatid separation	27	47	2.54e-16
GO:BP	GO:0033048	negative regulation of mitotic sister chromatid segregation	27	47	2.54e-16
GO:BP	GO:0033046	negative regulation of sister chromatid segregation	27	47	2.54e-16
GO:BP	GO:0033047	regulation of mitotic sister chromatid segregation	28	52	4.07e-16
GO:BP	GO:1901991	negative regulation of mitotic cell cycle phase transition	50	163	4.07e-16
GO:BP	GO:0045839	negative regulation of mitotic nuclear division	28	54	7.28e-16
GO:BP	GO:0051985	negative regulation of chromosome segregation	27	48	8.18e-16
GO:BP	GO:1905819	negative regulation of chromosome separation	27	48	8.18e-16
GO:BP	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	26	46	8.73e-16
GO:BP	GO:0010965	regulation of mitotic sister chromatid separation	29	58	9.13e-16
GO:BP	GO:1902100	negative regulation of metaphase/anaphase transition of cell cycle	26	47	3.09e-15
GO:BP	GO:0071174	mitotic spindle checkpoint signaling	25	44	3.15e-15
GO:BP	GO:0071173	spindle assembly checkpoint signaling	25	44	3.15e-15
GO:BP	GO:0007094	mitotic spindle assembly checkpoint signaling	25	44	3.15e-15
GO:BP	GO:0033045	regulation of sister chromatid segregation	37	99	3.31e-15
GO:BP	GO:0051306	mitotic sister chromatid separation	29	61	3.98e-15
GO:BP	GO:0031577	spindle checkpoint signaling	25	45	5.75e-15
GO:BP	GO:0045786	negative regulation of cell cycle	72	334	6.63e-15
GO:BP	GO:0007088	regulation of mitotic nuclear division	37	100	2.19e-14
GO:BP	GO:0051784	negative regulation of nuclear division	28	57	2.42e-14
GO:BP	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	34	91	2.42e-14
GO:BP	GO:0090068	positive regulation of cell cycle process	54	206	3.99e-14
GO:BP	GO:0030071	regulation of mitotic metaphase/anaphase transition	32	88	5.95e-14
GO:BP	GO:2001251	negative regulation of chromosome organization	33	90	6.13e-14
GO:BP	GO:0044784	metaphase/anaphase transition of cell cycle	34	92	6.71e-14
GO:BP	GO:0006974	cellular response to DNA damage stimulus	125	789	8.02e-14
GO:BP	GO:0007051	spindle organization	49	186	9.37e-14
GO:BP	GO:0051783	regulation of nuclear division	40	115	1.44e-13
GO:BP	GO:1902099	regulation of metaphase/anaphase transition of cell cycle	32	89	1.55e-13
GO:BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	44	156	2.41e-13
GO:BP	GO:0033044	regulation of chromosome organization	54	233	7.02e-13
GO:BP	GO:0006259	DNA metabolic process	140	890	1.13e-12
GO:BP	GO:0008608	attachment of spindle microtubules to kinetochore	21	42	1.25e-12
GO:BP	GO:0007052	mitotic spindle organization	30	128	2.38e-12
GO:BP	GO:0006281	DNA repair	90	535	2.09e-11
GO:BP	GO:0045787	positive regulation of cell cycle	62	278	3.03e-11
GO:BP	GO:0031570	DNA integrity checkpoint signaling	36	126	3.33e-11
GO:BP	GO:0000281	mitotic cytokinesis	26	81	5.65e-11
GO:BP	GO:0051225	spindle assembly	27	118	2.06e-10
GO:BP	GO:0000226	microtubule cytoskeleton organization	92	552	8.91e-10
GO:BP	GO:0000910	cytokinesis	37	163	2.87e-09
GO:BP	GO:0044774	mitotic DNA integrity checkpoint signaling	26	82	4.05e-09
GO:BP	GO:0044839	cell cycle G2/M phase transition	36	148	7.14e-09
GO:BP	GO:0032465	regulation of cytokinesis	26	79	7.89e-09
GO:BP	GO:0090329	regulation of DNA-templated DNA replication	21	54	8.49e-09
GO:BP	GO:0006270	DNA replication initiation	17	35	1.02e-08
GO:BP	GO:0051988	regulation of attachment of spindle microtubules to kinetochore	11	18	1.06e-08
GO:BP	GO:0000077	DNA damage checkpoint signaling	30	118	1.29e-08
GO:BP	GO:0042770	signal transduction in response to DNA damage	39	173	1.54e-08
GO:BP	GO:0051984	positive regulation of chromosome segregation	13	25	2.73e-08
GO:BP	GO:0000086	G2/M transition of mitotic cell cycle	33	134	2.78e-08
GO:BP	GO:1903046	meiotic cell cycle process	42	136	3.19e-08
GO:BP	GO:0007080	mitotic metaphase plate congression	16	55	3.36e-08
GO:BP	GO:0051255	spindle midzone assembly	9	12	3.75e-08
GO:BP	GO:0051231	spindle elongation	9	12	3.75e-08
GO:BP	GO:0044773	mitotic DNA damage checkpoint signaling	24	78	4.00e-08
GO:BP	GO:0032508	DNA duplex unwinding	24	75	4.05e-08
GO:BP	GO:0061640	cytoskeleton-dependent cytokinesis	26	103	4.12e-08
GO:BP	GO:0006275	regulation of DNA replication	32	124	4.93e-08
GO:BP	GO:0051310	metaphase plate congression	21	69	5.74e-08
GO:BP	GO:0051383	kinetochore organization	13	23	6.24e-08
GO:BP	GO:0051256	mitotic spindle midzone assembly	8	9	7.67e-08
GO:BP	GO:0071459	protein localization to chromosome, centromeric region	17	42	7.96e-08
GO:BP	GO:0010212	response to ionizing radiation	27	130	8.26e-08
GO:BP	GO:0007017	microtubule-based process	96	756	8.26e-08
GO:BP	GO:0050000	chromosome localization	23	82	1.77e-07
GO:BP	GO:0032392	DNA geometric change	24	81	1.81e-07
GO:BP	GO:0000022	mitotic spindle elongation	8	10	2.08e-07
GO:BP	GO:0034502	protein localization to chromosome	28	110	2.58e-07
GO:BP	GO:0090307	mitotic spindle assembly	17	69	3.92e-07
GO:BP	GO:0010639	negative regulation of organelle organization	54	318	4.22e-07
GO:BP	GO:0033043	regulation of organelle organization	112	1023	4.43e-07
GO:BP	GO:0140013	meiotic nuclear division	37	121	8.28e-07
GO:BP	GO:1905820	positive regulation of chromosome separation	12	26	9.35e-07
GO:BP	GO:0051303	establishment of chromosome localization	21	75	1.00e-06
GO:BP	GO:0071103	DNA conformation change	24	88	1.11e-06
GO:BP	GO:1900262	regulation of DNA-directed DNA polymerase activity	9	13	1.18e-06
GO:BP	GO:1900264	positive regulation of DNA-directed DNA polymerase activity	9	13	1.18e-06
GO:BP	GO:0032467	positive regulation of cytokinesis	15	33	1.46e-06
GO:BP	GO:1901976	regulation of cell cycle checkpoint	16	45	1.68e-06
GO:BP	GO:0051052	regulation of DNA metabolic process	72	459	1.68e-06
GO:BP	GO:0010389	regulation of G2/M transition of mitotic cell cycle	24	92	1.88e-06
GO:BP	GO:0140694	non-membrane-bounded organelle assembly	54	355	2.12e-06
GO:BP	GO:0051315	attachment of mitotic spindle microtubules to kinetochore	9	21	2.27e-06
GO:BP	GO:0051321	meiotic cell cycle	44	188	2.31e-06
GO:BP	GO:0034508	centromere complex assembly	13	30	2.57e-06
GO:BP	GO:0065004	protein-DNA complex assembly	40	185	2.70e-06
GO:BP	GO:0010332	response to gamma radiation	14	50	2.88e-06
GO:BP	GO:1903490	positive regulation of mitotic cytokinesis	6	7	3.21e-06
GO:BP	GO:0034501	protein localization to kinetochore	10	18	3.23e-06
GO:BP	GO:1903083	protein localization to condensed chromosome	10	18	3.23e-06
GO:BP	GO:0006541	glutamine metabolic process	4	23	3.41e-06
GO:BP	GO:1902749	regulation of cell cycle G2/M phase transition	25	102	3.51e-06
GO:BP	GO:0051302	regulation of cell division	28	144	6.25e-06
GO:BP	GO:0045931	positive regulation of mitotic cell cycle	26	113	6.31e-06
GO:BP	GO:0071824	protein-DNA complex subunit organization	41	204	8.50e-06
GO:BP	GO:0006268	DNA unwinding involved in DNA replication	10	22	8.51e-06
GO:BP	GO:0071478	cellular response to radiation	28	155	8.81e-06
GO:BP	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	15	43	1.28e-05
GO:BP	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	20	76	1.90e-05
GO:BP	GO:0006996	organelle organization	313	2971	2.09e-05
GO:BP	GO:1901992	positive regulation of mitotic cell cycle phase transition	20	86	2.32e-05
GO:BP	GO:0044786	cell cycle DNA replication	14	40	2.37e-05
GO:BP	GO:1902969	mitotic DNA replication	8	14	2.73e-05
GO:BP	GO:0009314	response to radiation	48	349	2.76e-05
GO:BP	GO:0033554	cellular response to stress	184	1677	3.48e-05
GO:BP	GO:0045132	meiotic chromosome segregation	20	69	4.12e-05
GO:BP	GO:0090232	positive regulation of spindle checkpoint	7	12	4.29e-05
GO:BP	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint	7	12	4.29e-05
GO:BP	GO:0090266	regulation of mitotic cell cycle spindle assembly checkpoint	9	19	4.63e-05
GO:BP	GO:0090231	regulation of spindle checkpoint	9	19	4.63e-05
GO:BP	GO:1903504	regulation of mitotic spindle checkpoint	9	19	4.63e-05
GO:BP	GO:0071168	protein localization to chromatin	10	49	4.78e-05
GO:BP	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore	6	11	6.34e-05
GO:BP	GO:0000727	double-strand break repair via break-induced replication	7	11	6.79e-05
GO:BP	GO:1902412	regulation of mitotic cytokinesis	6	8	6.97e-05
GO:BP	GO:0072331	signal transduction by p53 class mediator	29	160	7.78e-05
GO:BP	GO:0006271	DNA strand elongation involved in DNA replication	8	15	7.78e-05
GO:BP	GO:0007098	centrosome cycle	26	126	8.20e-05
GO:BP	GO:1901989	positive regulation of cell cycle phase transition	23	103	1.05e-04
GO:BP	GO:0071897	DNA biosynthetic process	33	175	1.05e-04
GO:BP	GO:0045005	DNA-templated DNA replication maintenance of fidelity	15	50	1.22e-04
GO:BP	GO:0071479	cellular response to ionizing radiation	15	68	1.32e-04
GO:BP	GO:1901978	positive regulation of cell cycle checkpoint	8	19	1.49e-04
GO:BP	GO:0033260	nuclear DNA replication	12	35	1.94e-04
GO:BP	GO:1902423	regulation of attachment of mitotic spindle microtubules to kinetochore	5	8	1.95e-04
GO:BP	GO:1902425	positive regulation of attachment of mitotic spindle microtubules to kinetochore	5	8	1.95e-04
GO:BP	GO:0008315	G2/MI transition of meiotic cell cycle	5	5	2.07e-04
GO:BP	GO:0044818	mitotic G2/M transition checkpoint	14	50	2.07e-04
GO:BP	GO:0000076	DNA replication checkpoint signaling	8	15	2.13e-04
GO:BP	GO:0051656	establishment of organelle localization	53	375	2.16e-04
GO:BP	GO:0007076	mitotic chromosome condensation	8	19	2.59e-04
GO:BP	GO:0009064	glutamine family amino acid metabolic process	4	61	2.82e-04
GO:BP	GO:0007062	sister chromatid cohesion	14	51	2.92e-04
GO:BP	GO:0061982	meiosis I cell cycle process	25	80	3.06e-04
GO:BP	GO:0006302	double-strand break repair	41	270	3.14e-04
GO:BP	GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	22	87	3.19e-04
GO:BP	GO:0030174	regulation of DNA-templated DNA replication initiation	7	14	3.33e-04
GO:BP	GO:0031023	microtubule organizing center organization	26	136	4.14e-04
GO:BP	GO:1905832	positive regulation of spindle assembly	5	7	4.44e-04
GO:BP	GO:0060236	regulation of mitotic spindle organization	10	42	4.53e-04
GO:BP	GO:1904029	regulation of cyclin-dependent protein kinase activity	22	90	4.80e-04
GO:BP	GO:0007095	mitotic G2 DNA damage checkpoint signaling	11	35	4.80e-04
GO:BP	GO:0090224	regulation of spindle organization	11	45	4.96e-04
GO:BP	GO:0090235	regulation of metaphase plate congression	6	13	5.22e-04
GO:BP	GO:0051640	organelle localization	63	498	5.24e-04
GO:BP	GO:0010972	negative regulation of G2/M transition of mitotic cell cycle	15	60	5.75e-04
GO:BP	GO:0051382	kinetochore assembly	8	18	6.89e-04
GO:BP	GO:0044771	meiotic cell cycle phase transition	6	7	6.91e-04
GO:BP	GO:0006310	DNA recombination	43	256	6.98e-04
GO:BP	GO:0071480	cellular response to gamma radiation	8	29	7.12e-04
GO:BP	GO:0000724	double-strand break repair via homologous recombination	27	147	7.18e-04
GO:BP	GO:0010032	meiotic chromosome condensation	4	6	7.84e-04
GO:BP	GO:1902750	negative regulation of cell cycle G2/M phase transition	15	62	8.27e-04
GO:BP	GO:0071214	cellular response to abiotic stimulus	35	264	8.35e-04
GO:BP	GO:0104004	cellular response to environmental stimulus	35	264	8.35e-04
GO:BP	GO:1902751	positive regulation of cell cycle G2/M phase transition	10	30	8.57e-04
GO:BP	GO:1905821	positive regulation of chromosome condensation	4	5	9.07e-04
GO:BP	GO:0000725	recombinational repair	27	151	1.06e-03
GO:BP	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	20	94	1.20e-03
GO:BP	GO:0051129	negative regulation of cellular component organization	73	586	1.24e-03
GO:BP	GO:0000912	assembly of actomyosin apparatus involved in cytokinesis	4	6	1.32e-03
GO:BP	GO:0000915	actomyosin contractile ring assembly	4	6	1.32e-03
GO:BP	GO:0034644	cellular response to UV	14	83	1.41e-03
GO:BP	GO:0030261	chromosome condensation	12	34	1.41e-03
GO:BP	GO:0009411	response to UV	19	137	1.46e-03
GO:BP	GO:0030330	DNA damage response, signal transduction by p53 class mediator	7	68	1.46e-03
GO:BP	GO:0031571	mitotic G1 DNA damage checkpoint signaling	9	27	1.61e-03
GO:BP	GO:0000731	DNA synthesis involved in DNA repair	9	36	1.67e-03
GO:BP	GO:0006334	nucleosome assembly	12	80	1.68e-03
GO:BP	GO:1901970	positive regulation of mitotic sister chromatid separation	7	18	1.78e-03
GO:BP	GO:0040001	establishment of mitotic spindle localization	10	36	1.80e-03
GO:BP	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	9	27	2.09e-03
GO:BP	GO:0044819	mitotic G1/S transition checkpoint signaling	9	27	2.10e-03
GO:BP	GO:0006513	protein monoubiquitination	14	83	2.10e-03
GO:BP	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	7	16	2.15e-03
GO:BP	GO:0032506	cytokinetic process	9	39	2.34e-03
GO:BP	GO:0061644	protein localization to CENP-A containing chromatin	5	17	2.35e-03
GO:BP	GO:1902117	positive regulation of organelle assembly	15	75	2.47e-03
GO:BP	GO:0044837	actomyosin contractile ring organization	4	7	2.75e-03
GO:BP	GO:0007127	meiosis I	22	76	3.07e-03
GO:BP	GO:0051053	negative regulation of DNA metabolic process	23	118	3.16e-03
GO:BP	GO:0051653	spindle localization	12	52	3.29e-03
GO:BP	GO:0002227	innate immune response in mucosa	4	8	3.71e-03
GO:BP	GO:0034198	cellular response to amino acid starvation	7	48	4.15e-03
GO:BP	GO:0035878	nail development	2	7	4.15e-03
GO:BP	GO:0031297	replication fork processing	11	42	4.15e-03
GO:BP	GO:0000302	response to reactive oxygen species	14	160	4.25e-03
GO:BP	GO:1902292	cell cycle DNA replication initiation	3	5	4.37e-03
GO:BP	GO:1902315	nuclear cell cycle DNA replication initiation	3	5	4.37e-03
GO:BP	GO:1902975	mitotic DNA replication initiation	3	5	4.37e-03
GO:BP	GO:0090169	regulation of spindle assembly	8	32	5.21e-03
GO:BP	GO:1990928	response to amino acid starvation	7	50	5.21e-03
GO:BP	GO:0035494	SNARE complex disassembly	3	3	5.33e-03
GO:BP	GO:0007143	female meiotic nuclear division	9	25	6.20e-03
GO:BP	GO:0051293	establishment of spindle localization	11	48	6.23e-03
GO:BP	GO:0034728	nucleosome organization	12	98	6.32e-03
GO:BP	GO:0110032	positive regulation of G2/MI transition of meiotic cell cycle	3	3	6.77e-03
GO:BP	GO:0006301	postreplication repair	8	34	7.00e-03
GO:BP	GO:0033314	mitotic DNA replication checkpoint signaling	5	9	7.00e-03
GO:BP	GO:0000132	establishment of mitotic spindle orientation	7	31	7.75e-03
GO:BP	GO:1903925	response to bisphenol A	3	4	7.78e-03
GO:BP	GO:1903926	cellular response to bisphenol A	3	4	7.78e-03
GO:BP	GO:0070925	organelle assembly	87	803	7.81e-03
GO:BP	GO:0000082	G1/S transition of mitotic cell cycle	27	203	8.07e-03
GO:BP	GO:1990227	paranodal junction maintenance	1	2	8.41e-03
GO:BP	GO:0046601	positive regulation of centriole replication	4	9	8.74e-03
GO:BP	GO:1901605	alpha-amino acid metabolic process	4	161	8.82e-03
GO:BP	GO:0010638	positive regulation of organelle organization	49	432	8.86e-03
GO:BP	GO:0051294	establishment of spindle orientation	9	36	9.09e-03
GO:BP	GO:0051781	positive regulation of cell division	15	64	1.03e-02
GO:BP	GO:0009084	glutamine family amino acid biosynthetic process	2	17	1.07e-02
GO:BP	GO:0072719	cellular response to cisplatin	3	4	1.07e-02
GO:BP	GO:0007089	traversing start control point of mitotic cell cycle	3	4	1.10e-02
GO:BP	GO:2001021	negative regulation of response to DNA damage stimulus	15	76	1.14e-02
GO:BP	GO:0051298	centrosome duplication	14	68	1.14e-02
GO:BP	GO:0002385	mucosal immune response	4	11	1.20e-02
GO:BP	GO:0007057	spindle assembly involved in female meiosis I	3	4	1.20e-02
GO:BP	GO:0030510	regulation of BMP signaling pathway	4	84	1.37e-02
GO:BP	GO:0006290	pyrimidine dimer repair	1	7	1.39e-02
GO:BP	GO:0070192	chromosome organization involved in meiotic cell cycle	12	44	1.45e-02
GO:BP	GO:0060623	regulation of chromosome condensation	4	9	1.46e-02
GO:BP	GO:0019985	translesion synthesis	6	24	1.47e-02
GO:BP	GO:0097193	intrinsic apoptotic signaling pathway	36	260	1.50e-02
GO:BP	GO:0090306	meiotic spindle assembly	4	8	1.51e-02
GO:BP	GO:1902254	negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator	7	22	1.57e-02
GO:BP	GO:0022616	DNA strand elongation	9	35	1.58e-02
GO:BP	GO:0085020	protein K6-linked ubiquitination	4	9	1.58e-02
GO:BP	GO:0006979	response to oxidative stress	21	349	1.58e-02
GO:BP	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	6	17	1.59e-02
GO:BP	GO:0071496	cellular response to external stimulus	8	268	1.61e-02
GO:BP	GO:0016446	somatic hypermutation of immunoglobulin genes	5	11	1.62e-02
GO:BP	GO:0033209	tumor necrosis factor-mediated signaling pathway	4	77	1.63e-02
GO:BP	GO:0002251	organ or tissue specific immune response	4	13	1.63e-02
GO:BP	GO:2001055	positive regulation of mesenchymal cell apoptotic process	1	2	1.67e-02
GO:BP	GO:0035880	embryonic nail plate morphogenesis	1	3	1.67e-02
GO:BP	GO:0051795	positive regulation of timing of catagen	1	3	1.67e-02
GO:BP	GO:1901751	leukotriene A4 metabolic process	2	2	1.68e-02
GO:BP	GO:2001020	regulation of response to DNA damage stimulus	37	292	1.69e-02
GO:BP	GO:0016321	female meiosis chromosome segregation	3	5	1.72e-02
GO:BP	GO:0098910	regulation of atrial cardiac muscle cell action potential	3	4	1.82e-02
GO:BP	GO:0036297	interstrand cross-link repair	8	37	1.82e-02
GO:BP	GO:0023019	signal transduction involved in regulation of gene expression	2	14	1.98e-02
GO:BP	GO:0099607	lateral attachment of mitotic spindle microtubules to kinetochore	2	2	1.98e-02
GO:BP	GO:0071312	cellular response to alkaloid	8	29	2.06e-02
GO:BP	GO:0042772	DNA damage response, signal transduction resulting in transcription	6	18	2.08e-02
GO:BP	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	7	25	2.08e-02
GO:BP	GO:0051794	regulation of timing of catagen	1	4	2.10e-02
GO:BP	GO:0060364	frontal suture morphogenesis	1	4	2.10e-02
GO:BP	GO:0110030	regulation of G2/MI transition of meiotic cell cycle	3	3	2.10e-02
GO:BP	GO:0010824	regulation of centrosome duplication	9	44	2.10e-02
GO:BP	GO:1901995	positive regulation of meiotic cell cycle phase transition	3	3	2.10e-02
GO:BP	GO:0007144	female meiosis I	5	9	2.10e-02
GO:BP	GO:0042637	catagen	1	4	2.10e-02
GO:BP	GO:0002076	osteoblast development	2	12	2.15e-02
GO:BP	GO:0009913	epidermal cell differentiation	2	114	2.17e-02
GO:BP	GO:0044843	cell cycle G1/S phase transition	28	225	2.17e-02
GO:BP	GO:0072718	response to cisplatin	3	5	2.18e-02
GO:BP	GO:0019752	carboxylic acid metabolic process	7	679	2.18e-02
GO:BP	GO:0000212	meiotic spindle organization	5	14	2.19e-02
GO:BP	GO:0070914	UV-damage excision repair	1	13	2.22e-02
GO:BP	GO:0002566	somatic diversification of immune receptors via somatic mutation	5	12	2.23e-02
GO:BP	GO:0048818	positive regulation of hair follicle maturation	2	5	2.27e-02
GO:BP	GO:0051782	negative regulation of cell division	5	15	2.27e-02
GO:BP	GO:0003283	atrial septum development	5	23	2.29e-02
GO:BP	GO:2000045	regulation of G1/S transition of mitotic cell cycle	20	146	2.47e-02
GO:BP	GO:0043436	oxoacid metabolic process	7	698	2.49e-02
GO:BP	GO:0090427	activation of meiosis	1	3	2.50e-02
GO:BP	GO:0007010	cytoskeleton organization	134	1222	2.56e-02
GO:BP	GO:0006082	organic acid metabolic process	7	703	2.57e-02
GO:BP	GO:0006520	amino acid metabolic process	4	234	2.59e-02
GO:BP	GO:2000001	regulation of DNA damage checkpoint	7	25	2.61e-02
GO:BP	GO:0035825	homologous recombination	10	43	2.68e-02
GO:BP	GO:0031573	mitotic intra-S DNA damage checkpoint signaling	3	15	2.73e-02
GO:BP	GO:0001833	inner cell mass cell proliferation	5	14	2.78e-02
GO:BP	GO:0019276	UDP-N-acetylgalactosamine metabolic process	2	2	2.80e-02
GO:BP	GO:1903551	regulation of extracellular exosome assembly	3	6	2.88e-02
GO:BP	GO:0032792	negative regulation of CREB transcription factor activity	1	4	2.90e-02
GO:BP	GO:0072711	cellular response to hydroxyurea	4	10	2.96e-02
GO:BP	GO:1904666	regulation of ubiquitin protein ligase activity	6	24	2.96e-02
GO:BP	GO:0051754	meiotic sister chromatid cohesion, centromeric	3	4	2.97e-02
GO:BP	GO:1901993	regulation of meiotic cell cycle phase transition	4	5	2.97e-02
GO:BP	GO:0071482	cellular response to light stimulus	14	96	3.04e-02
GO:BP	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	6	20	3.08e-02
GO:BP	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	12	61	3.13e-02
GO:BP	GO:0071356	cellular response to tumor necrosis factor	5	156	3.21e-02
GO:BP	GO:0061312	BMP signaling pathway involved in heart development	1	7	3.29e-02
GO:BP	GO:0097012	response to granulocyte macrophage colony-stimulating factor	2	6	3.32e-02
GO:BP	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	2	6	3.32e-02
GO:BP	GO:0009612	response to mechanical stimulus	10	155	3.33e-02
GO:BP	GO:0072593	reactive oxygen species metabolic process	11	154	3.33e-02
GO:BP	GO:1902010	negative regulation of translation in response to endoplasmic reticulum stress	1	1	3.39e-02
GO:BP	GO:0035611	protein branching point deglutamylation	1	1	3.52e-02
GO:BP	GO:0035518	histone H2A monoubiquitination	1	23	3.52e-02
GO:BP	GO:0086016	AV node cell action potential	4	9	3.59e-02
GO:BP	GO:0086027	AV node cell to bundle of His cell signaling	4	9	3.59e-02
GO:BP	GO:0045617	negative regulation of keratinocyte differentiation	1	3	3.64e-02
GO:BP	GO:2000104	negative regulation of DNA-templated DNA replication	5	14	3.67e-02
GO:BP	GO:1904668	positive regulation of ubiquitin protein ligase activity	4	11	3.68e-02
GO:BP	GO:0007064	mitotic sister chromatid cohesion	7	29	3.70e-02
GO:BP	GO:0038101	sequestering of nodal from receptor via nodal binding	1	1	3.75e-02
GO:BP	GO:0006970	response to osmotic stress	6	66	3.85e-02
GO:BP	GO:0009628	response to abiotic stimulus	28	862	3.86e-02
GO:BP	GO:0006542	glutamine biosynthetic process	1	2	3.86e-02
GO:BP	GO:0042542	response to hydrogen peroxide	9	103	3.89e-02
GO:BP	GO:0051438	regulation of ubiquitin-protein transferase activity	9	53	3.91e-02
GO:BP	GO:0072710	response to hydroxyurea	4	11	3.92e-02
GO:BP	GO:0044851	hair cycle phase	1	9	3.92e-02
GO:BP	GO:0044848	biological phase	1	9	3.92e-02
GO:BP	GO:0048819	regulation of hair follicle maturation	1	9	3.92e-02
GO:BP	GO:0034312	diol biosynthetic process	3	20	3.92e-02
GO:BP	GO:0060363	cranial suture morphogenesis	1	8	3.92e-02
GO:BP	GO:0007056	spindle assembly involved in female meiosis	3	5	4.02e-02
GO:BP	GO:2001170	negative regulation of ATP biosynthetic process	2	3	4.11e-02
GO:BP	GO:0098901	regulation of cardiac muscle cell action potential	7	30	4.17e-02
GO:BP	GO:1904975	response to bleomycin	2	2	4.19e-02
GO:BP	GO:1904976	cellular response to bleomycin	2	2	4.19e-02
GO:BP	GO:0006298	mismatch repair	7	29	4.21e-02
GO:BP	GO:0034612	response to tumor necrosis factor	5	171	4.23e-02
GO:BP	GO:0051445	regulation of meiotic cell cycle	11	45	4.24e-02
GO:BP	GO:0021694	cerebellar Purkinje cell layer formation	1	12	4.24e-02
GO:BP	GO:0060346	bone trabecula formation	1	9	4.24e-02
GO:BP	GO:0071971	extracellular exosome assembly	3	6	4.24e-02
GO:BP	GO:0002072	optic cup morphogenesis involved in camera-type eye development	2	4	4.31e-02
GO:BP	GO:0008544	epidermis development	2	207	4.36e-02
GO:BP	GO:0030509	BMP signaling pathway	4	123	4.45e-02
GO:BP	GO:0033522	histone H2A ubiquitination	1	32	4.45e-02
GO:BP	GO:0051128	regulation of cellular component organization	125	1947	4.47e-02
GO:BP	GO:0046605	regulation of centrosome cycle	9	51	4.54e-02
GO:BP	GO:0019372	lipoxygenase pathway	3	5	4.57e-02
GO:BP	GO:1903779	regulation of cardiac conduction	6	23	4.61e-02
GO:BP	GO:0044260	cellular macromolecule metabolic process	262	2777	4.61e-02
GO:BP	GO:0032223	negative regulation of synaptic transmission, cholinergic	1	1	4.61e-02
GO:BP	GO:0050910	detection of mechanical stimulus involved in sensory perception of sound	1	8	4.61e-02
GO:BP	GO:0044210	‘de novo’ CTP biosynthetic process	1	2	4.61e-02
GO:BP	GO:0045217	cell-cell junction maintenance	1	13	4.61e-02
GO:BP	GO:0071619	phosphorylation of RNA polymerase II C-terminal domain serine 2 residues	2	3	4.65e-02
GO:BP	GO:0046173	polyol biosynthetic process	5	47	4.71e-02
GO:BP	GO:0010390	histone monoubiquitination	1	35	4.71e-02
GO:BP	GO:0006914	autophagy	38	507	4.77e-02
GO:BP	GO:0061919	process utilizing autophagic mechanism	38	507	4.77e-02
GO:BP	GO:0009267	cellular response to starvation	11	151	4.78e-02
GO:BP	GO:0060088	auditory receptor cell stereocilium organization	1	9	4.78e-02
GO:BP	GO:0051798	positive regulation of hair follicle development	1	9	4.78e-02
GO:BP	GO:0019731	antibacterial humoral response	4	15	4.81e-02
GO:BP	GO:0090100	positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	11	99	4.85e-02
GO:BP	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	3	23	4.87e-02
GO:BP	GO:0006297	nucleotide-excision repair, DNA gap filling	3	5	4.87e-02
GO:BP	GO:0070601	centromeric sister chromatid cohesion	4	11	4.89e-02
GO:BP	GO:0071364	cellular response to epidermal growth factor stimulus	5	41	4.89e-02
GO:BP	GO:0008156	negative regulation of DNA replication	7	26	4.90e-02
GO:BP	GO:0021692	cerebellar Purkinje cell layer morphogenesis	1	16	4.94e-02
GO:BP	GO:0045683	negative regulation of epidermis development	1	6	4.96e-02
GO:BP	GO:0061430	bone trabecula morphogenesis	1	12	4.96e-02
GO:BP	GO:0048598	embryonic morphogenesis	3	440	4.96e-02
GO:BP	GO:0045605	negative regulation of epidermal cell differentiation	1	6	4.96e-02
GO:BP	GO:2001053	regulation of mesenchymal cell apoptotic process	1	5	4.96e-02
GO:BP	GO:0051100	negative regulation of binding	2	136	4.96e-02
GO:BP	GO:0046338	phosphatidylethanolamine catabolic process	2	4	4.96e-02
GO:BP	GO:0046340	diacylglycerol catabolic process	2	3	4.96e-02
KEGG	KEGG:04110	Cell cycle	35	121	1.89e-10
KEGG	KEGG:04115	p53 signaling pathway	24	65	6.99e-09
KEGG	KEGG:03030	DNA replication	16	35	3.09e-08
KEGG	KEGG:03430	Mismatch repair	9	22	5.05e-04
KEGG	KEGG:03440	Homologous recombination	10	39	1.09e-03
KEGG	KEGG:05322	Systemic lupus erythematosus	13	61	1.09e-03
KEGG	KEGG:05034	Alcoholism	9	122	2.23e-03
KEGG	KEGG:04217	Necroptosis	5	106	3.64e-03
KEGG	KEGG:03460	Fanconi anemia pathway	12	48	4.27e-03
KEGG	KEGG:04613	Neutrophil extracellular trap formation	5	110	4.27e-03
KEGG	KEGG:04964	Proximal tubule bicarbonate reclamation	2	20	1.25e-02
KEGG	KEGG:03420	Nucleotide excision repair	10	43	1.64e-02
KEGG	KEGG:01524	Platinum drug resistance	11	65	1.97e-02
KEGG	KEGG:03410	Base excision repair	8	33	2.64e-02

What I will do is take the terms from the tope three KEGG pathways and look at count changes or at FC values. Updated later.

DXspecific response (only the subset unique to Dox)

Whoa! look at the calcium things

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:2001258	negative regulation of cation channel activity	5	30	8.98e-03
GO:BP	GO:0034763	negative regulation of transmembrane transport	8	95	8.98e-03
GO:BP	GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity	4	23	8.98e-03
GO:BP	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	5	27	1.11e-02
GO:BP	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	3	10	1.20e-02
GO:BP	GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	4	20	1.30e-02
GO:BP	GO:0032413	negative regulation of ion transmembrane transporter activity	6	51	1.31e-02
GO:BP	GO:0051280	negative regulation of release of sequestered calcium ion into cytosol	3	11	1.31e-02
GO:BP	GO:1903170	negative regulation of calcium ion transmembrane transport	5	35	1.57e-02
GO:BP	GO:0051284	positive regulation of sequestering of calcium ion	3	13	1.57e-02
GO:BP	GO:0032410	negative regulation of transporter activity	6	58	1.57e-02
GO:BP	GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling	4	25	1.57e-02
GO:BP	GO:1904063	negative regulation of cation transmembrane transport	6	64	2.11e-02
GO:BP	GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	4	27	2.11e-02
GO:BP	GO:1901019	regulation of calcium ion transmembrane transporter activity	5	71	2.15e-02
GO:BP	GO:0034766	negative regulation of monoatomic ion transmembrane transport	6	69	2.80e-02
GO:BP	GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	4	28	2.91e-02
GO:BP	GO:1903514	release of sequestered calcium ion into cytosol by endoplasmic reticulum	4	28	3.10e-02
GO:BP	GO:2001257	regulation of cation channel activity	6	98	3.15e-02
GO:BP	GO:0051926	negative regulation of calcium ion transport	5	45	3.31e-02

I feel a little dumb for not remembering this results on Wednesday…. now that I ran this using the new adj. p value of < 0.05, I am more confident they are consistent. as above, I will pull the specific genes and look at logCPM of these genes soon to examine if the change is seen in the other AC genes at 24 hours.

No Response genes n=5727

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0009100	glycoprotein metabolic process	174	317	4.39e-04
GO:BP	GO:0022904	respiratory electron transport chain	67	103	5.22e-04
GO:BP	GO:0045229	external encapsulating structure organization	131	231	5.22e-04
GO:BP	GO:0019646	aerobic electron transport chain	52	74	5.22e-04
GO:BP	GO:0030198	extracellular matrix organization	130	230	5.22e-04
GO:BP	GO:0043062	extracellular structure organization	130	231	6.06e-04
GO:BP	GO:0042773	ATP synthesis coupled electron transport	55	82	8.58e-04
GO:BP	GO:0042775	mitochondrial ATP synthesis coupled electron transport	55	82	8.58e-04
GO:BP	GO:0006486	protein glycosylation	107	189	2.71e-03
GO:BP	GO:0043413	macromolecule glycosylation	107	189	2.71e-03
GO:BP	GO:0070085	glycosylation	114	204	2.76e-03
GO:BP	GO:0006812	monoatomic cation transport	323	668	3.62e-03
GO:BP	GO:0006811	monoatomic ion transport	367	774	7.37e-03
GO:BP	GO:0009101	glycoprotein biosynthetic process	135	254	9.85e-03
GO:BP	GO:0006119	oxidative phosphorylation	78	134	1.06e-02
GO:BP	GO:0002181	cytoplasmic translation	88	155	1.12e-02
GO:BP	GO:0022900	electron transport chain	81	141	1.26e-02
GO:BP	GO:0007160	cell-matrix adhesion	99	179	1.35e-02
GO:BP	GO:0009060	aerobic respiration	99	180	1.73e-02
GO:BP	GO:0007229	integrin-mediated signaling pathway	54	89	3.50e-02
GO:BP	GO:0030001	metal ion transport	269	563	3.59e-02
GO:BP	GO:0055085	transmembrane transport	455	996	3.59e-02
GO:BP	GO:0045333	cellular respiration	117	222	3.59e-02
GO:BP	GO:0010466	negative regulation of peptidase activity	83	149	3.59e-02
GO:BP	GO:0098655	monoatomic cation transmembrane transport	259	541	3.75e-02
GO:BP	GO:1901135	carbohydrate derivative metabolic process	413	899	3.99e-02
GO:BP	GO:0034220	monoatomic ion transmembrane transport	298	633	4.66e-02
GO:BP	GO:0034645	cellular macromolecule biosynthetic process	468	1030	4.66e-02
KEGG	KEGG:03010	Ribosome	84	127	6.40e-07
KEGG	KEGG:05171	Coronavirus disease - COVID-19	100	162	2.53e-06
KEGG	KEGG:04510	Focal adhesion	105	175	6.34e-06
KEGG	KEGG:04512	ECM-receptor interaction	48	69	4.97e-05
KEGG	KEGG:05415	Diabetic cardiomyopathy	98	169	9.70e-05
KEGG	KEGG:00190	Oxidative phosphorylation	65	106	3.78e-04
KEGG	KEGG:00531	Glycosaminoglycan degradation	15	16	5.15e-04
KEGG	KEGG:04714	Thermogenesis	107	195	6.63e-04
KEGG	KEGG:05012	Parkinson disease	120	226	1.34e-03
KEGG	KEGG:04810	Regulation of actin cytoskeleton	98	179	1.34e-03
KEGG	KEGG:05208	Chemical carcinogenesis - reactive oxygen species	101	186	1.46e-03
KEGG	KEGG:05020	Prion disease	114	220	6.11e-03
KEGG	KEGG:04151	PI3K-Akt signaling pathway	129	254	6.95e-03
KEGG	KEGG:05146	Amoebiasis	39	64	1.33e-02
KEGG	KEGG:04141	Protein processing in endoplasmic reticulum	85	161	1.36e-02
KEGG	KEGG:04932	Non-alcoholic fatty liver disease	71	131	1.36e-02
KEGG	KEGG:00000	KEGG root term	2295	5534	2.43e-02
KEGG	KEGG:04066	HIF-1 signaling pathway	50	89	2.63e-02
KEGG	KEGG:05205	Proteoglycans in cancer	87	170	3.21e-02
KEGG	KEGG:04260	Cardiac muscle contraction	39	67	3.21e-02
KEGG	KEGG:05414	Dilated cardiomyopathy	44	78	3.82e-02

##GO:BP full figure 24 DEG analysis

NULL

##Visualization of FC in cormotif sets


Attaching package: 'limma'

The following object is masked from 'package:BiocGenerics':

    plotMA

corrplot 0.92 loaded

[1] TRUE

##CVRI poster figures not run

R version 4.2.2 (2022-10-31 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19044)

Matrix products: default

locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

attached base packages:
[1] grid      stats     graphics  grDevices utils     datasets  methods  
[8] base     

other attached packages:
 [1] RColorBrewer_1.1-3  pheatmap_1.0.12     corrplot_0.92      
 [4] limma_3.52.4        ggpubr_0.6.0        cowplot_1.1.1      
 [7] ggVennDiagram_1.2.2 scales_1.2.1        kableExtra_1.3.4   
[10] VennDiagram_1.7.3   futile.logger_1.4.3 gridExtra_2.3      
[13] BiocGenerics_0.42.0 gprofiler2_0.2.1    lubridate_1.9.2    
[16] forcats_1.0.0       stringr_1.5.0       dplyr_1.1.0        
[19] purrr_1.0.1         readr_2.1.4         tidyr_1.3.0        
[22] tibble_3.1.8        ggplot2_3.4.1       tidyverse_2.0.0    
[25] workflowr_1.7.0    

loaded via a namespace (and not attached):
 [1] colorspace_2.1-0     ggsignif_0.6.4       ellipsis_0.3.2      
 [4] class_7.3-21         rprojroot_2.0.3      fs_1.6.1            
 [7] rstudioapi_0.14      proxy_0.4-27         farver_2.1.1        
[10] bit64_4.0.5          fansi_1.0.4          xml2_1.3.3          
[13] cachem_1.0.7         knitr_1.42           jsonlite_1.8.4      
[16] broom_1.0.3          shiny_1.7.4          compiler_4.2.2      
[19] httr_1.4.5           backports_1.4.1      fastmap_1.1.1       
[22] lazyeval_0.2.2       cli_3.6.0            later_1.3.0         
[25] formatR_1.14         htmltools_0.5.4      tools_4.2.2         
[28] gtable_0.3.1         glue_1.6.2           Rcpp_1.0.10         
[31] carData_3.0-5        jquerylib_0.1.4      vctrs_0.5.2         
[34] svglite_2.1.1        crosstalk_1.2.0      xfun_0.37           
[37] ps_1.7.2             rvest_1.0.3          timechange_0.2.0    
[40] mime_0.12            lifecycle_1.0.3      rstatix_0.7.2       
[43] getPass_0.2-2        vroom_1.6.1          hms_1.1.2           
[46] promises_1.2.0.1     parallel_4.2.2       lambda.r_1.2.4      
[49] yaml_2.3.7           sass_0.4.5           stringi_1.7.12      
[52] highr_0.10           e1071_1.7-13         rlang_1.0.6         
[55] pkgconfig_2.0.3      systemfonts_1.0.4    evaluate_0.20       
[58] sf_1.0-9             htmlwidgets_1.6.1    labeling_0.4.2      
[61] bit_4.0.5            processx_3.8.0       tidyselect_1.2.0    
[64] magrittr_2.0.3       R6_2.5.1             generics_0.1.3      
[67] DBI_1.1.3            pillar_1.8.1         whisker_0.4.1       
[70] withr_2.5.0          units_0.8-1          abind_1.4-5         
[73] crayon_1.5.2         car_3.1-1            futile.options_1.0.1
[76] KernSmooth_2.23-20   utf8_1.2.3           plotly_4.10.1       
[79] RVenn_1.1.0          tzdb_0.3.0           rmarkdown_2.20      
[82] data.table_1.14.8    callr_3.7.3          git2r_0.31.0        
[85] digest_0.6.31        classInt_0.4-9       webshot_0.5.4       
[88] xtable_1.8-4         httpuv_1.6.9         munsell_0.5.0       
[91] viridisLite_0.4.1    bslib_0.4.2

GO analysis

ERM

2023-04-20