Last updated: 2023-03-12
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Knit directory: paperscripts/
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We have the workbook and html output for all the figures in Urbut et al 2023.
Figure 1 Here is the hazard rate and proportion of variation explained in the UK Biobank
Figure 1n Here is the hazard rate and proportion of variation explained in the Framingham Offspring Cohort
Figure 2 Here are the relative and absolute rates of CAD by PRS and PCE percentile for three age categories
Figure 3 Here is the stratification by age and PCE using the UK Biobank
Figure 4 Here is the proportion of future events captured using a PCE threshold of 7.5% versus a PRS threshold of greater than 80% to predict future events
Figure 5 Here is the AUC of models using genomic, non genomic or both
Figure 1 Supplemental Here is the net reclassification of events and non events using PCE versus PRS
Figure 2 Supplemental Here is the proportion of individuals in each PCE risk class by age
We also have a variety of exlucsion tables and summary tables
Table 1 Here is the summary characterisitics of each cohort, and of division by ASCVD and PRS risk calss in the UK Biobank subset
Exclusions Here are the flowcharts of exclusionary criteria for creating the cohorts used in these analyses.