Dose-Response Assay Compilation

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Last updated: 2021-03-21

Checks: 6 1

Knit directory: toxin_dose_responses/

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Untracked files:
    Untracked:  data/drugclasses.csv
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Unstaged changes:
    Modified:   analysis/doseresponsemodels.Rmd

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These are the previous versions of the repository in which changes were made to the R Markdown (analysis/toxin8strains.Rmd) and HTML (docs/toxin8strains.html) files. If you’ve configured a remote Git repository (see ?wflow_git_remote), click on the hyperlinks in the table below to view the files as they were in that past version.

File	Version	Author	Date	Message
Rmd	32ad79a	sam-widmayer	2021-03-21	heatmap outputs
Rmd	7ccc7de	sam-widmayer	2021-03-21	heatmap outputs
Rmd	01b3361	sam-widmayer	2021-03-21	heatmap outputs
Rmd	7eb07f1	sam-widmayer	2021-03-21	toxin23 updates and Worm_Length filter for MDHD data
html	7ae886c	sam-widmayer	2021-03-14	Build site.
Rmd	3f4a99b	sam-widmayer	2021-03-14	integrate toxin22 results
html	212e0ae	sam-widmayer	2021-03-08	Build site.
html	cb6e132	sam-widmayer	2021-03-06	Build site.
Rmd	46c9647	sam-widmayer	2021-03-06	static working directory
Rmd	41bdaa0	sam-widmayer	2021-03-05	dynamic working directory
Rmd	0c9d312	sam-widmayer	2021-03-05	initiate toxin DRC analysis repo

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Purpose:

• Compile past assay results.
• Provide dose-response curves for each toxin.

Analysis Date: March 21, 2021

Assay Summary

Past versions of “Assay Diagnostics-1.png”

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cb6e132	sam-widmayer	2021-03-06

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7ae886c	sam-widmayer	2021-03-14
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   Metadata_Experiment bleach    median cv.censor
1             toxin09A      1 0.3836145         0
2             toxin10A      1 0.4305145         0
3             toxin11A      1 0.4277093         0
4             toxin14A      1 0.3309190         0
5             toxin14A      2 0.6202207         1
6             toxin14A      3 0.3139512         0
7             toxin14B      1 0.3531075         0
8             toxin14B      2 0.6821373         1
9             toxin14B      3 0.4144394         0
10            toxin15A      1 0.3776043         0
11            toxin15A      2 0.3237794         0
12            toxin15A      3 0.5858180         1
13            toxin15B      1 0.3014705         0
14            toxin15B      2 0.3782805         0
15            toxin15B      3 0.5791055         1
16            toxin16A      1 0.3024091         0
17            toxin16A      2 0.6394078         1
18            toxin16A      3 0.6430524         1
19            toxin17A      1 0.3203867         0
20            toxin17A      2 0.5750981         1
21            toxin17A      3 0.3401813         0
22            toxin18A      1 0.3202607         0
23            toxin18A      2 0.3228881         0
24            toxin18A      3 0.3338709         0
25            toxin19A      1 0.3333869         0
26            toxin19A      2 0.3179010         0
27            toxin19A      3 0.3330344         0
28            toxin22A      1 0.2625332         0
29            toxin22A      2 0.2967801         0
30            toxin22A      3 0.2706957         0
31            toxin23A      1 0.3243216         0
32            toxin23A      2 0.3411546         0
33            toxin23A      3 0.2809086         0

                         Df Sum Sq Mean Sq F value  Pr(>F)    
assay                    12 1.8077  0.1506  14.987 < 2e-16 ***
as.factor(bleach)         2 0.6899  0.3450  34.318 1.1e-13 ***
strain                    7 0.0920  0.0131   1.307   0.248    
assay:as.factor(bleach)  18 1.8073  0.1004   9.989 < 2e-16 ***
Residuals               218 2.1913  0.0101                    
---
Signif. codes:  0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1

Silver

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Cadmium

[1] "Excluding toxin09A: Inconsistent Response"

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Copper

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Nickel

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Paraquat

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Zinc

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Pyraclostrobin

[1] "Excluding toxin11A: Inconsistent Response"

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Aldicarb

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cb6e132	sam-widmayer	2021-03-06

Chlorfenapyr

[1] "Excluding toxin09A, toxin10A, toxin11A, toxin12A: No Response/Variable Dilution"

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Methomyl

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Methyl Mercury

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Triphenyl phosphate

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Arsenic trioxide

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Carbaryl

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Carboxin

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Chlorpyrifos

[1] "Excluding toxin17A: No Response"

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cb6e132	sam-widmayer	2021-03-06

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Lead (II) nitrate

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Atrazine

[1] "Excluding toxin16A: Inaccurate Dilution Series"

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2,4-D

Malathion

Chlorothalonil

Deltamethrin

Error in optim(startVec, opfct, hessian = TRUE, method = optMethod, control = list(maxit = maxIt,  : 
  non-finite finite-difference value [3]
[1] "Unable to optimize model"
[1] "Unable to optimize model"

Manganese dichloride

Propoxur

EC Estimates

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EC10

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EC50

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EC90

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Summary Tables

Table: Aldicarb Estimates

Strain   Weibull        Log-Logistic   Lognormal    
-------  -------------  -------------  -------------
ECA396   112.12±6.55    126.01±6.39    126.59±6.09  
CB4856   124.11±23.91   135.99±26.53   133.08±22.25 
ECA36    129.21±10.9    149.93±11.74   148.64±11.04 
MY16     74.86±4.91     80.84±4.6      81.03±4.53   
XZ1516   135.86±9.43    155.1±10.51    157.17±10.39 
RC301    91.18±6.87     100.35±5.66    99.9±5.37    
PD1074   99.62±10.59    110.12±9.27    111.48±9.37  
ECA248   102.21±10.69   111.97±9.05    112.18±8.55  


Table: Aldicarb Estimates

Strain   Weibull        Log-Logistic   Lognormal    
-------  -------------  -------------  -------------
ECA396   343.77±15.91   344.41±16.9    350.5±18     
CB4856   277.31±23.53   258.2±27.9     252.71±24.74 
ECA36    341.46±15.6    327±14.07      326.36±14.27 
MY16     194.49±7.58    193.41±8.81    194.99±9.12  
XZ1516   363.37±13.79   358.51±14.65   355.04±14.38 
RC301    271.04±15.97   276.53±13.81   280.95±14.65 
PD1074   227.68±10.98   216.37±11.45   216.59±10.98 
ECA248   261.96±13.08   256.49±13.34   254.59±13.06 


Table: Aldicarb Estimates

Strain   Weibull        Log-Logistic    Lognormal    
-------  -------------  --------------  -------------
ECA396   702.05±55.35   941.37±103.34   970.5±107.62 
CB4856   462.87±43.69   490.26±63.07    479.87±58.5  
ECA36    634.32±48.97   713.19±70.11    716.57±65.63 
MY16     357.41±22.4    462.74±49.16    469.25±50.66 
XZ1516   680.19±42.77   828.69±84       802.02±75.75 
RC301    542.7±62.63    762.04±84.34    790.13±88.88 
PD1074   385.57±28.83   425.11±45.82    420.81±43.49 
ECA248   477.21±46.82   587.58±63.39    577.76±59.72 


Table: Arsenic trioxide Estimates

Strain   Weibull         Log-Logistic   Lognormal     
-------  --------------  -------------  --------------
PD1074   424.78±310.18   852.9±932.35   639.16±201.42 


Table: Atrazine Estimates

Strain   Weibull         Log-Logistic     Lognormal     
-------  --------------  ---------------  --------------
ECA248   231.03±45.22    305.76±96.3      610.18±710.96 
PD1074   323.78±159.61   430.95±237.65    NA            
XZ1516   259.56±83.83    338.98±134.82    604.71±670.12 
RC301    180.06±17.9     221.04±30.53     279.45±92.4   
CB4856   302.15±214.96   452.74±379.63    NA            
ECA36    551.13±889.49   832.27±1429.92   NA            
ECA396   259.49±90.99    400.28±199.19    NA            


Table: Atrazine Estimates

Strain   Weibull         Log-Logistic    Lognormal 
-------  --------------  --------------  ----------
ECA248   740.46±247.7    NA              NA        
XZ1516   914.35±412.62   NA              NA        
RC301    603.8±106.15    824.22±223.15   NA        


Table: Cadmium dichloride Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
MY16     28.14±1.64   31.13±1.67     31.59±1.72 
XZ1516   26.6±1.6     29.42±1.58     30.05±1.6  
PD1074   23.53±1.31   26.57±1.35     27.06±1.33 
ECA36    26.9±1.84    29.62±1.73     30.16±1.7  
ECA396   29.31±1.55   32.27±1.51     32.85±1.53 
RC301    23.34±1.43   26.19±1.52     26.79±1.54 
ECA248   22.65±1.73   26.23±1.88     26.63±1.75 
CB4856   20.86±1.29   23.39±1.27     23.74±1.23 


Table: Cadmium dichloride Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
MY16     64.99±2.21   63.75±2.62     63.21±2.44 
XZ1516   68.01±2.06   69.01±3.08     67.94±3.02 
PD1074   61.28±1.93   60.8±2.43      60.08±2.3  
ECA36    71.73±2.59   74.71±4.46     73.75±4.71 
ECA396   66.46±1.97   64.6±2.33      64.11±2.13 
RC301    62.37±2.07   63.72±2.98     62.59±2.91 
ECA248   55.81±3.09   54.95±2.94     54.87±2.85 
CB4856   63.35±2.51   67.13±4.23     66.89±4.73 


Table: Cadmium dichloride Estimates

Strain   Weibull       Log-Logistic   Lognormal    
-------  ------------  -------------  -------------
MY16     110.8±5.68    130.56±12.6    126.51±11.24 
XZ1516   123.7±6.08    161.83±17.21   153.63±16.17 
PD1074   112.75±5.64   139.09±13.24   133.39±11.7  
ECA36    134±8.18      188.45±25.35   180.32±25.7  
ECA396   111.97±4.91   129.34±10.75   125.14±9.36  
RC301    116.68±6.33   155.04±17.73   146.24±16.32 
ECA248   99.15±9.98    115.09±15.76   113.06±13.81 
CB4856   128.58±8.32   192.63±26.29   188.48±28.18 


Table: Carbaryl Estimates

Strain   Weibull        Log-Logistic   Lognormal     
-------  -------------  -------------  --------------
RC301    153.86±13.45   206.66±31.25   318.49±148.7  
MY16     115.77±4.5     131.85±4.29    135.52±4.16   
XZ1516   138.51±5.63    160.03±6.16    167.91±8.08   
ECA248   215.06±13.53   263.15±26.42   350.16±107.75 
CB4856   200.77±7.47    224.45±7.79    232.64±9.74   
ECA396   118.25±6.19    134.47±5.88    138.17±5.63   
ECA36    282.12±38.73   391.53±85.12   NA            


Table: Carbaryl Estimates

Strain   Weibull         Log-Logistic    Lognormal    
-------  --------------  --------------  -------------
RC301    560.72±88.19    899.1±242.48    NA           
MY16     329.43±10.08    372.72±19.75    377.73±25.18 
XZ1516   396.9±19.22     480.15±41.68    527.38±71.69 
ECA248   599.91±67.03    828.28±158.41   NA           
CB4856   477.83±21.16    543.72±40.07    589.88±68.61 
ECA396   334.69±14.2     365.03±24.39    365.57±28.19 
ECA36    823.29±165.63   NA              NA           


Table: Carbaryl Estimates

Strain   Weibull        Log-Logistic   Lognormal  
-------  -------------  -------------  -----------
MY16     641.47±34.4    NA             NA         
XZ1516   776.32±60.67   NA             NA         
CB4856   830.35±58.18   NA             NA         
ECA396   649.51±47.04   990.92±136.9   967.21±149 


Table: Carboxin Estimates

Strain   Weibull        Log-Logistic   Lognormal    
-------  -------------  -------------  -------------
RC301    245.37±13.69   268.12±13.33   271.54±13.17 
MY16     208.99±11.87   232.92±11.41   236.38±11.06 
XZ1516   246.6±16.77    281.8±17.27    286.26±17.03 
PD1074   294.44±24.48   321.2±23.59    326.03±23.43 
ECA248   264.83±20      294.25±19.9    298.93±19.58 
CB4856   218.08±16.13   242.89±15.96   246.14±15.48 
ECA396   270.53±11.22   295.77±10.69   298.53±10.38 
ECA36    343.43±23.11   376.82±22.71   382.09±22.25 


Table: Carboxin Estimates

Strain   Weibull        Log-Logistic   Lognormal    
-------  -------------  -------------  -------------
RC301    518.27±12.99   520.48±15.19   514.66±14.85 
MY16     542.31±16.17   559.04±22.25   551.86±22.67 
XZ1516   634.1±24.55    652.59±34.08   647.19±35.34 
PD1074   762.58±35.12   837.75±72.34   829.67±86.63 
ECA248   653.85±27.45   672.27±39.66   662.19±40.07 
CB4856   567.38±22.5    585.55±31.62   575.34±31.85 
ECA396   543.23±11.13   538.19±12.02   534.45±11.71 
ECA36    721.61±27.71   712.59±33.79   705.55±31.94 


Table: Carboxin Estimates

Strain   Weibull          Log-Logistic     Lognormal      
-------  ---------------  ---------------  ---------------
RC301    834.65±39.4      1010.37±74.89    975.44±68.53   
MY16     995.79±54.82     1341.73±127.72   1288.38±122.31 
XZ1516   1157.57±81.68    1511.25±193.26   1463.19±189.76 
PD1074   1398.49±106.11   NA               NA             
ECA248   1163.1±82.92     1535.93±209.95   1466.89±201.43 
CB4856   1043.54±72.96    1411.64±179.5    1344.81±169.67 
ECA396   847.09±31.39     979.33±52.28     956.83±47.61   
ECA36    1158.26±71.01    1347.56±144.72   1302.84±129.29 


Table: Chlorfenapyr Estimates

Strain   Weibull     Log-Logistic   Lognormal 
-------  ----------  -------------  ----------
ECA248   0.19±0.01   0.2±0.01       0.2±0.01  
XZ1516   0.31±0.01   0.35±0.02      0.35±0.02 
ECA36    0.94±0.03   1.03±0.03      1.04±0.02 
CB4856   0.29±0.01   0.29±0.01      0.29±0.01 
PD1074   0.35±0.01   0.35±0.01      0.34±0.01 
RC301    0.22±0.01   0.23±0.01      0.24±0.01 
MY16     0.21±0.01   0.22±0.01      0.23±0.01 
ECA396   NA          0.54±0.01      0.54±0.01 


Table: Chlorfenapyr Estimates

Strain   Weibull     Log-Logistic   Lognormal 
-------  ----------  -------------  ----------
ECA248   0.49±0.02   0.49±0.02      0.49±0.02 
XZ1516   0.67±0.01   0.67±0.01      0.67±0.01 
ECA36    1.65±0.04   1.53±0.05      1.54±0.04 
CB4856   0.56±0.01   0.56±0.01      0.55±0.01 
PD1074   0.6±0.01    0.61±0.01      0.61±0.01 
RC301    0.49±0.01   0.48±0.01      0.48±0.01 
MY16     0.51±0.01   0.5±0.01       0.5±0.01  
ECA396   NA          0.75±0.02      0.76±0.02 


Table: Chlorfenapyr Estimates

Strain   Weibull     Log-Logistic   Lognormal 
-------  ----------  -------------  ----------
ECA248   0.92±0.06   1.22±0.11      1.18±0.11 
XZ1516   1.1±0.05    1.27±0.08      1.27±0.07 
ECA36    2.35±0.1    2.27±0.17      2.26±0.15 
CB4856   0.85±0.02   1.06±0.05      1.05±0.04 
PD1074   0.84±0.02   1.07±0.04      1.1±0.04  
RC301    0.81±0.02   1±0.05         0.96±0.04 
MY16     0.89±0.03   1.13±0.06      1.1±0.06  
ECA396   NA          1.04±0.06      1.06±0.05 


Table: Chlorothalonil Estimates

Strain   Weibull       Log-Logistic   Lognormal   
-------  ------------  -------------  ------------
CB4856   56.12±15.88   57.18±11.76    58.03±11.27 
ECA36    5.77±2.69     10.92±10.63    26.4±69.2   
ECA396   36.35±5.25    44.47±8.22     52.94±23.97 
XZ1516   43.81±8.96    48.18±7.94     49.29±8.24  


Table: Chlorothalonil Estimates

Strain   Weibull        Log-Logistic    Lognormal     
-------  -------------  --------------  --------------
CB4856   120.03±12.84   143.37±47.58    154.83±101.63 
ECA36    81.35±75.96    240.94±452.37   NA            
ECA396   121.84±23.79   174.49±69.55    NA            
XZ1516   112.35±14.12   134.26±39.1     144.69±70.86  


Table: Chlorothalonil Estimates

Strain   Weibull        Log-Logistic   Lognormal 
-------  -------------  -------------  ----------
CB4856   194.87±42.46   NA             NA        
XZ1516   204.75±47.75   NA             NA        


Table: Chlorpyrifos Estimates

Strain   Weibull       Log-Logistic   Lognormal   
-------  ------------  -------------  ------------
MY16     15.55±39.17   NA             NA          
XZ1516   2.72±0.14     3.2±0.18       3.53±0.37   
PD1074   2.71±4.57     8.49±13.73     NA          
ECA248   2.06±0.98     3.57±2.32      12.24±14.97 
CB4856   3.88±3.06     10.87±10.59    NA          
ECA396   3.79±6.17     10.36±20.26    NA          
ECA36    1.81±0.11     2.27±0.18      2.67±0.41   


Table: Chlorpyrifos Estimates

Strain   Weibull       Log-Logistic   Lognormal  
-------  ------------  -------------  -----------
XZ1516   8.19±0.61     10.39±1.32     13.29±3.38 
ECA248   17.87±12.12   NA             NA         
ECA36    7.39±0.76     10.32±1.69     14.8±4.74  


Table: Chlorpyrifos Estimates

Strain   Weibull      Log-Logistic   Lognormal 
-------  -----------  -------------  ----------
XZ1516   16.56±1.87   NA             NA        
ECA36    18.1±2.6     NA             NA        


Table: Copper(II) chloride Estimates

Strain   Weibull        Log-Logistic   Lognormal  
-------  -------------  -------------  -----------
PD1074   173.47±169.3   51.04±2.93     54.15±5.88 
ECA396   NA             52.9±3.01      53.22±2.88 
MY16     NA             50.75±2.98     59.68±4.3  


Table: Copper(II) chloride Estimates

Strain   Weibull   Log-Logistic   Lognormal    
-------  --------  -------------  -------------
ECA396   NA        112.25±9.11    118.79±15.9  
MY16     NA        108.46±8.44    96.73±4.04   
PD1074   NA        111.77±9.35    163.21±42.85 


Table: Copper(II) chloride Estimates

Strain   Weibull   Log-Logistic   Lognormal    
-------  --------  -------------  -------------
MY16     NA        NA             156.76±16.54 


Table: Deltamethrin Estimates

Strain   Weibull     Log-Logistic   Lognormal   
-------  ----------  -------------  ------------
PD1074   0.04±0.23   0.33±2.41      0.43±2.35   
CB4856   0.15±0.58   16.9±76.2      21.17±77.68 
ECA36    0±0         0±0            0±0         
MY16     0.21±0.46   0.49±2.62      0.91±4.32   
ECA396   0.18±0.67   26.52±85.9     1.36±3.48   
RC301    0.54±4.71   0.98±4.87      2.43±14.96  
XZ1516   0±0         NA             0±0         


Table: Deltamethrin Estimates

Strain   Weibull          Log-Logistic     Lognormal     
-------  ---------------  ---------------  --------------
ECA36    319.82±7642.14   38.64±432.2      22.07±288.54  
XZ1516   0±0              NA               24.67±2748.05 
PD1074   NA               306.46±2784.41   466.6±6933.93 
CB4856   NA               163.38±158.03    156.8±160.65  
ECA396   NA               181.73±145.01    NA            


Table: Deltamethrin Estimates

Strain   Weibull   Log-Logistic      Lognormal      
-------  --------  ----------------  ---------------
CB4856   NA        1579±4811.27      1161.27±2335.7 
ECA396   NA        1245.31±2455.33   NA             


Table: Lead(II) nitrate Estimates

Strain   Weibull         Log-Logistic   Lognormal 
-------  --------------  -------------  ----------
ECA36    233.52±141.68   556.99±619.9   NA        


Table: Malathion Estimates

Strain   Weibull       Log-Logistic   Lognormal   
-------  ------------  -------------  ------------
PD1074   23.38±5.57    32.16±5.74     34.37±5.75  
CB4856   37.47±12.69   51.06±12.04    52.8±11.44  
ECA36    52.21±23.96   74.08±24.82    82.72±26.64 
MY16     50.73±8.4     57.44±7.45     59.2±7.24   
ECA396   53.66±16.21   58.9±11.51     60.02±11.17 
RC301    26.79±7.52    33.87±7.53     36.44±7.55  
XZ1516   44.87±15.38   61.94±15.56    64.25±15    


Table: Malathion Estimates

Strain   Weibull         Log-Logistic    Lognormal     
-------  --------------  --------------  --------------
PD1074   154.38±10.86    157.82±12.24    154.06±11.59  
CB4856   175.75±20.78    171.94±20.27    169.99±19.63  
ECA36    826.08±749.85   673.98±575.97   762.07±748.28 
MY16     132.28±8.01     129.05±8.04     128.59±7.92   
ECA396   139.32±12.36    139.18±12.39    139.32±12.6   
RC301    111.73±8.82     111.5±8.85      110.06±8.54   
XZ1516   263.57±42.28    259.64±46.02    261.51±46.06  


Table: Malathion Estimates

Strain   Weibull         Log-Logistic     Lognormal     
-------  --------------  ---------------  --------------
PD1074   514.01±81.58    774.58±180.7     690.48±145.59 
CB4856   470.6±119.79    578.93±170.64    547.25±144.12 
MY16     243.66±28.53    289.95±44.88     279.33±41.09  
ECA396   255.9±63.76     328.87±82.9      323.39±79.35  
RC301    277.6±44.22     366.99±86.78     332.44±70.03  
XZ1516   814.57±288.25   1088.28±513.89   1064.4±475.3  


Table: Manganese dichloride Estimates

Strain   Weibull           Log-Logistic     Lognormal     
-------  ----------------  ---------------  --------------
PD1074   493.38±73.5       586.18±125.39    639.75±257.73 
MY16     1820.28±1973.15   NA               NA            
RC301    1141.28±129.55    1212.69±191.27   NA            


Table: Manganese dichloride Estimates

Strain   Weibull          Log-Logistic      Lognormal       
-------  ---------------  ----------------  ----------------
PD1074   1220.87±307.8    1655.46±1033.91   1906.81±2140.97 
RC301    1575.29±155.27   1871.07±792.42    NA              


Table: Manganese dichloride Estimates

Strain   Weibull         Log-Logistic   Lognormal 
-------  --------------  -------------  ----------
RC301    1934.45±391.2   NA             NA        


Table: Methomyl Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
ECA396   9.84±0.65    11.14±0.66     11.23±0.66 
CB4856   9.52±0.76    10.68±0.77     10.81±0.76 
ECA36    7.37±0.55    8.63±0.56      8.8±0.56   
MY16     9±0.75       10.18±0.8      10.26±0.8  
XZ1516   5.68±0.47    6.64±0.48      6.71±0.47  
RC301    9.3±0.77     10.53±0.73     10.53±0.71 
PD1074   6.36±0.6     7.36±0.6       7.51±0.6   
ECA248   11.36±0.79   12.7±0.78      12.77±0.79 


Table: Methomyl Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
ECA396   34.87±1.84   39.44±3.32     40.8±4.46  
CB4856   32.53±1.51   33.54±2.07     32.91±2.09 
ECA36    30.44±1.18   31.58±1.56     30.96±1.57 
MY16     28.98±1.33   28.96±1.66     28.3±1.61  
XZ1516   27.78±1.53   29.89±2.22     29.78±2.42 
RC301    33.24±1.81   36.71±2.83     37.62±3.53 
PD1074   26.35±1.83   29.04±2.83     29.15±3.24 
ECA248   39.06±1.59   40.21±2.03     39.87±2.12 


Table: Methomyl Estimates

Strain   Weibull      Log-Logistic   Lognormal    
-------  -----------  -------------  -------------
ECA396   78.11±6.67   139.62±23.51   148.17±31.72 
CB4856   71.16±5.49   105.36±14.51   100.13±13.94 
ECA36    75.12±5.42   115.61±13.69   108.87±12.94 
MY16     61.04±4.27   82.42±10.52    78.1±9.63    
XZ1516   76.39±7.1    134.48±21.6    132.25±22.74 
RC301    74.82±7.51   127.94±21.66   134.35±26.78 
PD1074   65.17±7.62   114.61±23.69   113.17±26.23 
ECA248   85.82±6.18   127.32±14.83   124.45±15.16 


Table: Methylmercury dichloride Estimates

Strain   Weibull     Log-Logistic   Lognormal 
-------  ----------  -------------  ----------
ECA396   1.05±0.12   1.31±0.13      1.35±0.13 
CB4856   0.68±0.08   0.91±0.1       0.96±0.1  
ECA36    0.79±0.13   1.1±0.18       1.23±0.22 
MY16     1.03±0.15   1.23±0.16      1.26±0.16 
XZ1516   0.74±0.13   1.04±0.17      1.14±0.21 
RC301    1.37±0.18   1.75±0.2       1.84±0.21 
PD1074   0.75±0.11   1.04±0.14      1.13±0.16 
ECA248   0.43±0.09   0.61±0.11      0.66±0.11 


Table: Methylmercury dichloride Estimates

Strain   Weibull      Log-Logistic   Lognormal   
-------  -----------  -------------  ------------
ECA396   8.69±0.85    10.59±1.5      10.53±1.71  
CB4856   6.92±0.61    7.66±0.88      7.5±0.9     
ECA36    15.07±3.2    21.54±7.13     25.33±11.29 
MY16     7.82±0.91    9.85±1.71      9.85±2.02   
XZ1516   11.83±2.33   18.22±5.86     22.18±10.44 
RC301    10.67±1.12   12.6±1.98      12.3±2.15   
PD1074   10.63±1.58   15.58±4.06     17.27±6.2   
ECA248   7.46±1.51    10.05±3.23     10.39±4.05  


Table: Methylmercury dichloride Estimates

Strain   Weibull       Log-Logistic    Lognormal     
-------  ------------  --------------  --------------
ECA396   33.31±5.19    85.89±23.96     81.91±25.72   
CB4856   30.2±4.65     64.78±16.36     58.97±15.12   
ECA36    98.83±30.79   NA              NA            
MY16     28.46±5.34    78.6±27.08      76.92±30.83   
XZ1516   68.94±21.27   NA              NA            
RC301    39.45±6.9     90.92±29.86     81.99±29.46   
PD1074   57.4±13.6     232.51±114.01   NA            
ECA248   45.92±14.94   165.72±102.87   162.97±119.71 


Table: Nickel dichloride Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
ECA396   49.7±2.61    50.33±2.22     50.28±1.96 
CB4856   50.68±2.88   51.22±2.44     51.25±2.14 
ECA36    55.05±3      59.22±1.98     60.9±2.14  
MY16     44.68±2.65   47.86±2.13     48.35±1.95 
PD1074   63.57±3.9    65.07±3.39     63.88±2.57 


Table: Nickel dichloride Estimates

Strain   Weibull       Log-Logistic   Lognormal    
-------  ------------  -------------  -------------
ECA396   86.77±1.57    85.7±1.93      84.36±1.9    
CB4856   88.1±1.64     87.41±2.05     86.07±2.05   
ECA36    109.91±3.92   125.24±10.24   137.56±20.11 
MY16     97.46±2.88    108.47±6.75    112.38±10.43 
PD1074   106.19±1.94   111.39±4.78    115.71±7.37  


Table: Nickel dichloride Estimates

Strain   Weibull        Log-Logistic   Lognormal   
-------  -------------  -------------  ------------
ECA396   123.76±3.33    145.93±7.24    141.52±6.56 
CB4856   125.33±3.7     149.18±8.14    144.55±7.32 
ECA36    170.78±14.03   NA             NA          
MY16     160.2±10.06    NA             NA          
PD1074   147.27±8.23    190.66±24.01   NA          


Table: Paraquat Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
MY16     42.55±3.71   40.32±2.97     39.4±2.61  
XZ1516   48.85±4.7    57.25±4.48     58.59±4.23 
CB4856   40.38±3.35   40.62±2.9      39.46±2.7  
RC301    15.69±1.75   22.62±1.85     22.84±1.66 
PD1074   29.52±2.8    30.58±2.27     29.76±2.09 
ECA248   29.11±3.68   28.73±2.32     28.45±2.28 
ECA36    56.24±4.19   46.32±3.49     45.9±3.55  
ECA396   15±1.59      21.65±1.64     21.82±1.5  


Table: Paraquat Estimates

Strain   Weibull        Log-Logistic   Lognormal    
-------  -------------  -------------  -------------
MY16     128.8±6.47     150.04±10.7    165.36±12.34 
XZ1516   314.23±28.05   290.36±31.96   302.27±32.74 
CB4856   127.35±6.29    138.36±8.69    149.29±10.9  
RC301    132.47±13.53   113.76±9.99    124.26±10.77 
PD1074   113.95±5.71    125.91±7.83    135.98±9.95  
ECA248   86.06±4.61     94.06±5.71     97.15±6.63   
ECA36    105.31±2.6     112.07±5.17    114.49±6.19  
ECA396   126±11.04      108.5±7.86     116.76±8.2   


Table: Paraquat Estimates

Strain   Weibull          Log-Logistic     Lognormal      
-------  ---------------  ---------------  ---------------
MY16     260.88±26.76     558.39±99.17     694.04±118.65  
XZ1516   1028.95±140.69   1472.55±311.42   1559.55±320.79 
CB4856   264.81±25.8      471.32±74.8      564.83±99.15   
RC301    515.82±96.76     572.24±118.93    676.16±128.82  
PD1074   269.52±29.21     518.5±83.42      621.42±110.72  
ECA248   171.73±23.93     307.92±49.24     331.75±57.85   
ECA36    157.05±6.09      271.17±37.15     285.56±44.67   
ECA396   489.11±80.73     543.61±93.74     624.93±97.74   


Table: Propoxur Estimates

Strain   Weibull        Log-Logistic   Lognormal    
-------  -------------  -------------  -------------
PD1074   102.71±17.64   128.4±18.79    135.24±17.89 
CB4856   204.62±27.23   227.04±26.01   229.08±24.5  
ECA36    147±24.67      172.88±24.52   174.54±23.12 
MY16     129.82±15.09   146.53±15.24   148.41±14.36 
ECA396   97.45±18.41    121.89±18.14   126.27±17.17 
RC301    85.92±11.72    103.31±11.88   108.98±11.35 
XZ1516   156.32±21.94   182.46±20.94   185.29±19.86 


Table: Propoxur Estimates

Strain   Weibull        Log-Logistic   Lognormal    
-------  -------------  -------------  -------------
PD1074   462.46±37.45   445.04±41.43   432.96±37.42 
CB4856   494.38±28.99   472.34±29.93   468.21±28.86 
ECA36    454.63±31.42   438.07±32.39   431.67±31.38 
MY16     367.86±17.6    359.19±19.56   352.43±18.96 
ECA396   353.17±31.85   336.68±31.64   334.18±29.93 
RC301    367.75±22.54   361.68±25.85   352.48±23.76 
XZ1516   407.88±25.76   388.23±25.26   386.84±24.42 


Table: Propoxur Estimates

Strain   Weibull          Log-Logistic     Lognormal      
-------  ---------------  ---------------  ---------------
PD1074   1206.49±150.61   1542.49±324.65   1386.09±248.18 
CB4856   867.38±76.98     982.68±122.49    956.97±109.58  
ECA36    933.57±107.49    1110.02±175.15   1067.6±151.52  
MY16     714.39±54.4      880.49±102.47    836.9±89.71    
ECA396   802.36±124.64    929.94±196.43    884.42±164.17  
RC301    928.94±98.21     1266.21±212.74   1140.01±168.61 
XZ1516   751.59±75.68     826.03±110       807.61±97.65   


Table: Pyraclostrobin Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
ECA396   5.42±0.39    6.91±0.42      7.13±0.43  
CB4856   8.51±1.14    10.83±1.28     11.03±1.28 
ECA36    11.85±0.96   14.98±0.96     15.33±0.94 
MY16     7.84±0.77    10.29±0.88     10.69±0.89 
XZ1516   9.5±1.03     12.27±1.17     12.67±1.17 
RC301    16.55±2.36   20.19±2.38     20.34±2.33 
PD1074   9.97±0.87    12.6±0.95      13.04±0.95 
ECA248   8.5±1.18     11.21±1.37     11.79±1.41 


Table: Pyraclostrobin Estimates

Strain   Weibull       Log-Logistic   Lognormal   
-------  ------------  -------------  ------------
ECA396   44.72±2.22    49.64±3.35     49.37±3.71  
CB4856   68.08±4.73    72.35±6.29     70.32±6.35  
ECA36    81.45±3.51    81.7±3.8       80.38±3.72  
MY16     81.2±4.85     91.25±7.69     89.48±8.27  
XZ1516   102.61±6.99   119.74±12.74   117.61±14.3 
RC301    84.31±6.05    82.94±6.28     82.36±6.2   
PD1074   81.06±4.14    85.87±5.79     83.61±5.83  
ECA248   77.68±5.47    81.55±7.5      78.53±7.29  


Table: Pyraclostrobin Estimates

Strain   Weibull        Log-Logistic     Lognormal      
-------  -------------  ---------------  ---------------
ECA396   171.64±14.83   356.9±52.78      341.77±54.86   
CB4856   256.12±32.58   483.31±101.09    448.15±93.9    
ECA36    278.2±22.11    445.58±49.48     421.41±44.95   
MY16     360.29±38.64   808.99±156.16    749.32±154.16  
XZ1516   467.63±53.98   1168.56±271.13   1091.33±282.29 
RC301    237.91±32.53   340.75±62.22     333.47±58.11   
PD1074   308.22±27.54   585.1±90.15      536.2±83.35    
ECA248   318.24±40.43   593.43±132.1     523±114.84     


Table: Silver nitrate Estimates

Strain   Weibull      Log-Logistic   Lognormal   
-------  -----------  -------------  ------------
MY16     1.9±0.36     2.56±0.43      2.92±0.6    
XZ1516   10.19±1.5    14.17±2.6      18.81±6.5   
PD1074   9.19±3.85    13.63±6.26     21.54±16.31 
ECA36    7.99±2.19    13.02±4.63     22.86±19.51 
ECA396   15.49±4.61   24.6±9.65      34.09±17.11 
RC301    8.82±4.57    16.29±10.34    42.07±47.6  
ECA248   5.21±0.89    7.75±1.63      10.84±4.12  
CB4856   13.38±7.22   24.63±16.23    82.1±109.58 


Table: Silver nitrate Estimates

Strain   Weibull         Log-Logistic   Lognormal  
-------  --------------  -------------  -----------
MY16     34.56±10.76     41±16.16       53.28±28.8 
XZ1516   97.71±23.41     158.17±54.42   NA         
PD1074   155.84±94.96    NA             NA         
ECA36    128.52±56.02    NA             NA         
ECA396   154.96±68.22    NA             NA         
RC301    189.39±138.95   NA             NA         
ECA248   82.11±24.12     142.61±59.43   NA         
CB4856   217.98±159.86   NA             NA         


Table: Silver nitrate Estimates

Strain   Weibull        Log-Logistic   Lognormal 
-------  -------------  -------------  ----------
MY16     219.44±99.15   NA             NA        


Table: Triphenyl phosphate Estimates

Strain   Weibull     Log-Logistic   Lognormal 
-------  ----------  -------------  ----------
ECA396   1.74±0.14   2.22±0.16      2.3±0.16  
CB4856   2.39±0.24   2.98±0.27      3.12±0.29 
ECA36    2.54±0.31   3.17±0.35      3.29±0.37 
MY16     0.49±0.07   0.71±0.08      0.77±0.08 
XZ1516   4.11±0.63   4.9±0.68       5.09±0.7  
RC301    1.1±0.18    1.49±0.21      1.57±0.22 
PD1074   3.86±0.35   4.47±0.37      4.58±0.36 
ECA248   1.56±0.16   2.02±0.18      2.1±0.18  


Table: Triphenyl phosphate Estimates

Strain   Weibull      Log-Logistic   Lognormal  
-------  -----------  -------------  -----------
ECA396   17.38±0.98   21.94±2.1      22.37±2.72 
CB4856   19.96±1.12   23.47±2.25     22.57±2.47 
ECA36    20.15±1.26   23.67±2.51     23.13±2.87 
MY16     11.81±1.18   17.73±3.3      18.67±4.53 
XZ1516   21.57±1.62   22.83±2.35     22.05±2.3  
RC301    15.76±1.67   21.97±4.53     23.04±6.53 
PD1074   19.98±0.91   20.89±1.29     20.17±1.27 
ECA248   17.13±1.13   21.42±2.4      21.79±3.08 


Table: Triphenyl phosphate Estimates

Strain   Weibull       Log-Logistic   Lognormal    
-------  ------------  -------------  -------------
ECA396   75.36±7.25    NA             NA           
CB4856   77.07±7.48    184.97±40.27   163.42±40.1  
ECA36    75.37±8.99    176.65±45.46   162.36±47.94 
MY16     89.87±15.5    NA             NA           
XZ1516   62.06±8.37    106.33±26.68   95.58±24.03  
RC301    85.87±16.45   NA             NA           
PD1074   56.97±4.53    97.55±14.14    88.93±12.82  
ECA248   79±9.24       NA             NA           


Table: 2,4-D Estimates

Strain   Weibull         Log-Logistic    Lognormal 
-------  --------------  --------------  ----------
MY16     813.53±414.55   906.75±493.35   NA        


Table: Zinc dichloride Estimates

Strain   Weibull       Log-Logistic   Lognormal   
-------  ------------  -------------  ------------
MY16     51.08±2.82    64.58±5.12     83.07±19.79 
XZ1516   52.16±3.55    64.9±5.84      77.48±16.39 
PD1074   77.82±16.89   120.54±36.25   NA          
ECA36    80.79±25.96   121.61±50.47   NA          
ECA396   35.12±1.72    41.24±1.71     43.03±1.98  
RC301    49.1±3.08     59.8±4.33      69.49±11.07 
ECA248   51.52±3.26    62.76±4.68     72.95±12.87 
CB4856   59.86±18.14   104.2±46.83    NA          


Table: Zinc dichloride Estimates

Strain   Weibull         Log-Logistic   Lognormal     
-------  --------------  -------------  --------------
MY16     197.78±19.81    289.39±53.79   NA            
XZ1516   199.17±23.09    278.8±57.38    NA            
PD1074   370.82±116.33   NA             NA            
ECA36    391.12±177.37   NA             NA            
ECA396   137.47±5.6      170.3±13.87    193.37±26.96  
RC301    183.65±16.31    250.99±40.75   371.7±135.69  
ECA248   186.36±17.6     254.84±45.6    368.98±155.29 
CB4856   364.74±162.68   NA             NA            


Table: Zinc dichloride Estimates

Strain   Weibull        Log-Logistic   Lognormal 
-------  -------------  -------------  ----------
ECA396   328.05±23.34   NA             NA        

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Session information

sessionInfo()

R version 4.0.4 (2021-02-15)
Platform: x86_64-apple-darwin17.0 (64-bit)
Running under: macOS Catalina 10.15.7

Matrix products: default
BLAS:   /Library/Frameworks/R.framework/Versions/4.0/Resources/lib/libRblas.dylib
LAPACK: /Library/Frameworks/R.framework/Versions/4.0/Resources/lib/libRlapack.dylib

locale:
[1] en_US.UTF-8/en_US.UTF-8/en_US.UTF-8/C/en_US.UTF-8/en_US.UTF-8

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] RColorBrewer_1.1-2 RCurl_1.98-1.2     ddpcr_1.15         kableExtra_1.3.4  
 [5] knitr_1.31         drc_3.0-1          MASS_7.3-53        easyXpress_0.1.0  
 [9] forcats_0.5.1      stringr_1.4.0      dplyr_1.0.4        purrr_0.3.4       
[13] readr_1.4.0        tidyr_1.1.2        tibble_3.1.0       ggplot2_3.3.3     
[17] tidyverse_1.3.0    workflowr_1.6.2   

loaded via a namespace (and not attached):
  [1] TH.data_1.0-10        colorspace_2.0-0      ellipsis_0.3.1       
  [4] rio_0.5.16            rprojroot_2.0.2       fs_1.5.0             
  [7] rstudioapi_0.13       farver_2.0.3          fansi_0.4.2          
 [10] mvtnorm_1.1-1         lubridate_1.7.9.2     xml2_1.3.2           
 [13] codetools_0.2-18      splines_4.0.4         readbitmap_0.1.5     
 [16] jsonlite_1.7.2        broom_0.7.5           dbplyr_2.1.0         
 [19] png_0.1-7             compiler_4.0.4        httr_1.4.2           
 [22] backports_1.2.1       assertthat_0.2.1      bmp_0.3              
 [25] Matrix_1.3-2          cli_2.3.1             later_1.1.0.1        
 [28] htmltools_0.5.1.1     tools_4.0.4           igraph_1.2.6         
 [31] gtable_0.3.0          glue_1.4.2            rebus.base_0.0-3     
 [34] Rcpp_1.0.6            carData_3.0-4         cellranger_1.1.0     
 [37] jquerylib_0.1.3       vctrs_0.3.6           svglite_2.0.0        
 [40] xfun_0.21             rebus.datetimes_0.0-1 openxlsx_4.2.3       
 [43] rvest_0.3.6           lifecycle_1.0.0       rebus.numbers_0.0-1  
 [46] gtools_3.8.2          zoo_1.8-8             scales_1.1.1         
 [49] hms_1.0.0             promises_1.2.0.1      sandwich_3.0-0       
 [52] yaml_2.2.1            curl_4.3              sass_0.3.1           
 [55] stringi_1.5.3         imager_0.42.7         highr_0.8            
 [58] plotrix_3.8-1         tiff_0.1-6            zip_2.1.1            
 [61] bitops_1.0-6          rlang_0.4.10          pkgconfig_2.0.3      
 [64] systemfonts_1.0.1     evaluate_0.14         lattice_0.20-41      
 [67] labeling_0.4.2        cowplot_1.1.1         tidyselect_1.1.0     
 [70] magrittr_2.0.1        R6_2.5.0              generics_0.1.0       
 [73] multcomp_1.4-16       DBI_1.1.1             pillar_1.5.0         
 [76] haven_2.3.1           whisker_0.4           foreign_0.8-81       
 [79] withr_2.4.1           rebus_0.1-3           survival_3.2-7       
 [82] abind_1.4-5           rebus.unicode_0.0-2   modelr_0.1.8         
 [85] crayon_1.4.1          car_3.0-10            utf8_1.1.4           
 [88] rmarkdown_2.7         jpeg_0.1-8.1          grid_4.0.4           
 [91] readxl_1.3.1          data.table_1.14.0     git2r_0.28.0         
 [94] reprex_1.0.0          digest_0.6.27         webshot_0.5.2        
 [97] httpuv_1.5.5          munsell_0.5.0         viridisLite_0.3.0    
[100] bslib_0.2.4