Last updated: 2022-07-18

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Knit directory: ampel-leipzig-meld/

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File Version Author Date Message
html fb43d01 Sebastian Gibb 2022-06-19 chore: rebuild site
html ebe29cf Sebastian Gibb 2022-06-16 chore: rebuild site
Rmd b4c182d Sebastian Gibb 2022-06-15 feat: add spearman correlation
Rmd 3a8124e Sebastian Gibb 2022-06-15 refactor: use zlog_data instead of imp_data
html 8035219 Sebastian Gibb 2022-06-15 chore: rebuild site
html d3e9462 Sebastian Gibb 2022-06-06 chore: rebuild site
html b20484a Sebastian Gibb 2022-06-06 chore: rebuild site
html 983ec69 Sebastian Gibb 2022-03-17 chore: rebuild site
Rmd d38da01 Sebastian Gibb 2022-03-17 feat: list correlations in table
html 373e7d8 Sebastian Gibb 2021-10-20 chore: rebuild site
html df8964f Sebastian Gibb 2021-10-15 chore: rebuild site
html c66640c Sebastian Gibb 2021-09-14 feat: first nnet tests
html afa48d9 Sebastian Gibb 2021-08-07 chore: rebuild site
Rmd 4478f6a Sebastian Gibb 2021-08-02 Revert "fix: working directory for targets"
Rmd cac14f6 Sebastian Gibb 2021-08-02 fix: working directory for targets
Rmd 3957af7 Sebastian Gibb 2021-08-02 refactor: move common yaml headers into _site.yml
html 3aab3e1 Sebastian Gibb 2021-08-01 chore: rebuild site
html 3810a79 Sebastian Gibb 2021-07-15 chore: rebuild site
html 2869556 Sebastian Gibb 2021-07-02 chore: rebuild site
html d9c37ec Sebastian Gibb 2021-07-02 chore: rebuild site
html 81fcc75 Sebastian Gibb 2021-06-11 chore: rebuild site
html 783c49f Sebastian Gibb 2021-06-11 chore: rebuild site
html aac7ea8 Sebastian Gibb 2021-06-11 chore: rebuild site
Rmd ba5de74 Sebastian Gibb 2021-06-11 fix: suppress package startup messages
html 6541fae Sebastian Gibb 2021-06-11 fix: add targets for missing/corrplot
Rmd 5d77d52 Sebastian Gibb 2021-06-11 fix: use imputed data for correlation
Rmd 3e38f5a Sebastian Gibb 2021-06-11 feat: add correlation plot

library("corrplot")
library("targets")
tar_load(zlog_data)

1 Correlation (pearson)

1.1 Plot

labv <- grep("_[SECQ]$", colnames(zlog_data), value = TRUE)
cr <- cor(zlog_data[labv], method = "pearson", use = "pairwise.complete.obs")
corrplot.mixed(
    cr,
    tl.pos = "lt", tl.col = "black", tl.cex = 0.75,
    number.cex = 0.25, number.font = 1L,
    order = "AOE"
)

Version Author Date
ebe29cf Sebastian Gibb 2022-06-16
8035219 Sebastian Gibb 2022-06-15
3810a79 Sebastian Gibb 2021-07-15
6541fae Sebastian Gibb 2021-06-11

1.2 Table

ut <- upper.tri(cr)
nms <- paste(
    colnames(cr)[col(cr)[ut]],
    rownames(cr)[row(cr)[ut]],
    sep = ":"
)
tbl <- data.frame(Values = nms, Correlation = cr[ut])
tbl <- tbl[order(-abs(tbl$Correlation)),]
knitr::kable(tbl, header = TRUE, row.names = FALSE, digits = 3L)
Values Correlation
BILID_S:BILI_S 0.959
CYSC_S:CRE_S 0.801
NA_S:CL_S 0.764
IL6_S:CRP_S 0.750
CA_S:ALB_S 0.734
INR_C:BILI_S 0.712
INR_C:BILID_S 0.702
PALB_S:CHE_S 0.692
ASAT_S:ALAT_S 0.685
IL6_S:CHE_S -0.685
IL6_S:ALB_S -0.683
CHE_S:ALB_S 0.676
PALB_S:ALB_S 0.655
CHE_S:CA_S 0.654
BILID_S:ALB_S -0.644
CHE_S:BILID_S -0.639
CHOLG_S:CHE_S 0.630
PALB_S:BILID_S -0.624
IL6_S:CYSC_S 0.611
GGT_S:AP_S 0.610
INR_C:CHOLG_S -0.607
IL6_S:BILID_S 0.604
PROT_S:ALB_S 0.597
PALB_S:CA_S 0.593
BILI_S:ALB_S -0.587
CHE_S:BILI_S -0.586
PALB_S:BILI_S -0.586
INR_C:IL6_S 0.585
PALB_S:IL6_S -0.582
IL6_S:BILI_S 0.577
INR_C:CHE_S -0.574
IL6_S:CHOLG_S -0.574
CRP_S:ALB_S -0.565
CRP_S:CHE_S -0.558
BILI_S:ASAT_S 0.555
BILID_S:ASAT_S 0.554
IL6_S:CA_S -0.549
INR_C:ALB_S -0.546
PROT_S:CA_S 0.544
PROT_S:CHOLG_S 0.543
PALB_S:INR_C -0.542
PROT_S:IL6_S -0.540
CA_S:BILID_S -0.533
PROT_S:BILI_S -0.520
PALB_S:CHOLG_S 0.515
PROT_S:BILID_S -0.509
PROT_S:INR_C -0.507
CRP_S:BILID_S 0.507
PROT_S:CHE_S 0.493
CYSC_S:CHE_S -0.489
CYSC_S:CRP_S 0.485
PALB_S:CRP_S -0.483
NA_S:CHE_S 0.480
CHOLG_S:BILI_S -0.479
CHOLG_S:CA_S 0.474
CA_S:BILI_S -0.470
CHOLG_S:BILID_S -0.470
CRP_S:BILI_S 0.461
CRP_S:CA_S -0.459
PTH_S:CRE_S 0.457
CYSC_S:ALB_S -0.453
CHOLG_S:ALB_S 0.444
INR_C:ASAT_S 0.438
INR_C:CA_S -0.430
PTH_S:CYSC_S 0.425
PALB_S:B_PLT_E 0.420
ASAT_S:ALB_S -0.419
INR_C:B_PLT_E -0.394
NA_S:ALB_S 0.394
BILID_S:B_PLT_E -0.393
CYSC_S:BILID_S 0.392
ASAT_S:AP_S 0.391
INR_C:CRP_S 0.390
BILI_S:B_PLT_E -0.385
IL6_S:CRE_S 0.381
CHOLG_S:B_PLT_E 0.381
VDT_OH_S:IL6_S -0.373
PROT_S:CYSC_S -0.372
CRP_S:CHOLG_S -0.366
PROT_S:CRP_S -0.366
CYSC_S:CHOLG_S -0.365
NA_S:IL6_S -0.362
IL6_S:ASAT_S 0.358
CYSC_S:BILI_S 0.355
INR_C:CYSC_S 0.345
VDT_OH_S:CHE_S 0.343
B_WBC_E:B_PLT_E 0.341
PROT_S:PALB_S 0.338
NA_S:CA_S 0.337
NA_S:BILID_S -0.336
CRP_S:ASAT_S 0.336
CRP_S:B_WBC_E 0.331
CA_S:B_PLT_E 0.330
CRP_S:AP_S 0.326
CHE_S:B_PLT_E 0.320
VDT_OH_S:CRP_S -0.319
NA_S:CRP_S -0.317
B_PLT_E:ALB_S 0.317
GGT_S:CHOLG_S 0.316
NA_S:BILI_S -0.316
VDT_OH_S:PALB_S 0.311
CYSC_S:CA_S -0.306
CRP_S:CRE_S 0.305
PROT_S:B_PLT_E 0.304
P_S:CRE_S 0.304
IL6_S:B_WBC_E 0.298
VDT_OH_S:CHOLG_S 0.295
VDT_OH_S:PTH_S -0.294
BILID_S:AP_S 0.290
CHE_S:ASAT_S -0.289
P_S:B_PLT_E 0.288
NA_S:INR_C -0.284
VDT_OH_S:CA_S 0.284
VDT_OH_S:CYSC_S -0.284
PROT_S:ASAT_S -0.282
B_PLT_E:B_MPV_E -0.281
PROT_S:CRE_S -0.281
VDT_OH_S:ALB_S 0.279
PALB_S:NA_S 0.278
PTH_S:PROT_S -0.277
VDT_OH_S:INR_C -0.276
PALB_S:ASAT_S -0.276
CRE_S:CHE_S -0.273
CRE_S:ALB_S -0.273
PTH_S:CA_S -0.271
AP_S:ALB_S -0.267
IL6_S:B_PLT_E -0.266
CL_S:B_WBC_E -0.265
AP_S:ALAT_S 0.261
PALB_S:CYSC_S -0.260
CA_S:ASAT_S -0.260
GGT_S:ASAT_S 0.260
VDT_OH_S:PROT_S 0.259
NA_S:CHOLG_S 0.259
GGT_S:ALAT_S 0.254
VDT_OH_S:BILID_S -0.252
VDT_OH_S:BILI_S -0.249
NA_S:B_WBC_E -0.245
CL_S:CHE_S 0.244
CRP_S:CL_S -0.243
BILI_S:ALAT_S 0.240
CRE_S:B_WBC_E 0.238
NA_S:CYSC_S -0.236
CYSC_S:B_WBC_E 0.225
B_WBC_E:ASAT_S 0.225
CRE_S:CHOLG_S -0.224
PTH_S:IL6_S 0.219
BILID_S:ALAT_S 0.216
IL6_S:CL_S -0.214
BILI_S:AP_S 0.212
GGT_S:CRP_S 0.211
PROT_S:B_WBC_E -0.210
GGT_S:B_PLT_E 0.210
P_S:CYSC_S 0.202
CL_S:B_MPV_E 0.201
CYSC_S:ASAT_S 0.197
CHE_S:AP_S -0.197
CHOLG_S:ASAT_S -0.196
CA_S:AP_S -0.195
CL_S:BILI_S -0.194
P_S:B_WBC_E 0.193
CRE_S:CA_S -0.192
NA_S:CRE_S -0.189
CL_S:BILID_S -0.186
VDT_OH_S:NA_S 0.183
INR_C:GGT_S -0.179
PTH_S:CRP_S 0.178
BILID_S:B_WBC_E 0.177
B_WBC_E:ALB_S -0.172
PALB_S:GGT_S 0.170
NA_S:B_MPV_E 0.170
NA_S:ASAT_S -0.169
PTH_S:CHOLG_S -0.168
BILI_S:B_WBC_E 0.167
VDT_OH_S:AP_S -0.167
NA_S:AP_S -0.166
PTH_S:B_WBC_E 0.165
VDT_OH_S:ASAT_S -0.163
VDT_OH_S:B_WBC_E -0.163
CYSC_S:AP_S 0.160
P_S:CL_S -0.159
INR_C:B_WBC_E 0.158
IL6_S:AP_S 0.153
CL_S:ALB_S 0.153
PROT_S:NA_S 0.146
PTH_S:CHE_S -0.145
P_S:NA_S -0.144
CYSC_S:B_PLT_E -0.143
CRE_S:BILID_S 0.143
P_S:INR_C -0.141
PALB_S:AP_S -0.140
B_WBC_E:ALAT_S 0.137
B_MPV_E:ALAT_S 0.136
PROT_S:GGT_S 0.136
B_PLT_E:ASAT_S -0.134
P_S:BILI_S -0.133
INR_C:CRE_S 0.132
PALB_S:P_S 0.131
INR_C:ALAT_S 0.130
B_PLT_E:AP_S 0.128
B_WBC_E:AP_S 0.126
PROT_S:ALAT_S -0.125
CHOLG_S:AP_S 0.124
INR_C:CL_S -0.124
GGT_S:B_WBC_E 0.121
P_S:CHOLG_S 0.118
CL_S:AP_S -0.118
VDT_OH_S:CRE_S -0.116
P_S:BILID_S -0.114
CL_S:ASAT_S -0.114
CRE_S:BILI_S 0.111
ALB_S:ALAT_S -0.109
CL_S:CA_S 0.109
CRP_S:ALAT_S 0.106
VDT_OH_S:CL_S 0.106
PTH_S:ALB_S -0.105
B_MPV_E:ASAT_S 0.104
PROT_S:P_S 0.103
CL_S:B_PLT_E -0.098
B_WBC_E:B_MPV_E -0.095
PTH_S:INR_C 0.094
CHE_S:B_WBC_E -0.094
P_S:CA_S 0.093
P_S:GGT_S 0.092
CYSC_S:CL_S -0.091
CRP_S:B_PLT_E -0.091
PTH_S:BILI_S 0.090
P_S:AP_S 0.090
PALB_S:CL_S 0.090
VDT_OH_S:B_MPV_E 0.087
CHOLG_S:B_WBC_E -0.086
PTH_S:BILID_S 0.086
PTH_S:GGT_S 0.081
PTH_S:ASAT_S 0.081
BILID_S:B_MPV_E 0.077
PTH_S:AP_S 0.076
CRP_S:B_MPV_E -0.071
CRE_S:CL_S -0.070
GGT_S:CL_S -0.069
VDT_OH_S:GGT_S -0.068
BILI_S:B_MPV_E 0.065
PALB_S:B_MPV_E -0.065
CYSC_S:ALAT_S -0.064
CRE_S:ALAT_S -0.062
IL6_S:B_MPV_E -0.059
CHE_S:B_MPV_E 0.058
CA_S:B_WBC_E -0.057
CL_S:CHOLG_S 0.054
GGT_S:B_MPV_E 0.054
CHE_S:ALAT_S 0.053
P_S:B_MPV_E -0.051
IL6_S:ALAT_S 0.051
VDT_OH_S:ALAT_S 0.049
CRE_S:ASAT_S 0.049
P_S:ALB_S 0.046
GGT_S:BILI_S -0.043
PALB_S:ALAT_S 0.042
PALB_S:B_WBC_E 0.041
GGT_S:CHE_S 0.041
NA_S:GGT_S -0.041
PALB_S:CRE_S -0.041
PTH_S:P_S 0.039
CA_S:B_MPV_E 0.038
PTH_S:B_MPV_E -0.038
B_MPV_E:AP_S 0.038
P_S:CRP_S -0.036
PROT_S:B_MPV_E -0.035
P_S:IL6_S -0.034
PROT_S:CL_S -0.033
PROT_S:AP_S -0.033
GGT_S:CYSC_S 0.032
PTH_S:ALAT_S -0.031
IL6_S:GGT_S -0.031
INR_C:AP_S 0.028
PTH_S:NA_S -0.028
CHOLG_S:ALAT_S 0.027
P_S:ALAT_S -0.025
NA_S:ALAT_S -0.023
NA_S:B_PLT_E 0.023
CA_S:ALAT_S -0.023
P_S:CHE_S 0.022
CHOLG_S:B_MPV_E -0.022
GGT_S:BILID_S 0.021
PTH_S:PALB_S 0.021
CRE_S:B_PLT_E -0.021
VDT_OH_S:P_S -0.021
PTH_S:CL_S -0.020
GGT_S:ALB_S 0.019
B_MPV_E:ALB_S -0.016
B_PLT_E:ALAT_S -0.015
CYSC_S:B_MPV_E 0.014
GGT_S:CRE_S -0.012
VDT_OH_S:B_PLT_E 0.012
CRE_S:AP_S 0.012
PTH_S:B_PLT_E -0.010
GGT_S:CA_S 0.010
P_S:ASAT_S 0.009
CL_S:ALAT_S -0.007
INR_C:B_MPV_E -0.003
CRE_S:B_MPV_E 0.003

2 Correlation (spearman)

2.1 Plot

cr <- cor(zlog_data[labv], method = "spearman", use = "pairwise.complete.obs")
corrplot.mixed(
    cr,
    tl.pos = "lt", tl.col = "black", tl.cex = 0.75,
    number.cex = 0.25, number.font = 1L,
    order = "AOE"
)

Version Author Date
ebe29cf Sebastian Gibb 2022-06-16

2.2 Table

ut <- upper.tri(cr)
nms <- paste(
    colnames(cr)[col(cr)[ut]],
    rownames(cr)[row(cr)[ut]],
    sep = ":"
)
tbl <- data.frame(Values = nms, Correlation = cr[ut])
tbl <- tbl[order(-abs(tbl$Correlation)),]
knitr::kable(tbl, header = TRUE, row.names = FALSE, digits = 3L)
Values Correlation
BILID_S:BILI_S 0.963
IL6_S:CRP_S 0.770
CHE_S:ALB_S 0.763
CA_S:ALB_S 0.751
CYSC_S:CRE_S 0.751
PALB_S:CHE_S 0.747
IL6_S:CHE_S -0.734
INR_C:BILID_S 0.734
INR_C:BILI_S 0.729
PALB_S:ALB_S 0.725
PALB_S:BILID_S -0.698
CHE_S:CA_S 0.696
IL6_S:ALB_S -0.694
CHE_S:BILID_S -0.686
BILID_S:ALB_S -0.679
PALB_S:INR_C -0.673
PALB_S:BILI_S -0.652
INR_C:CHE_S -0.650
PALB_S:CA_S 0.636
IL6_S:CYSC_S 0.634
NA_S:CL_S 0.632
ASAT_S:ALAT_S 0.626
CHE_S:BILI_S -0.615
PALB_S:IL6_S -0.614
BILI_S:ALB_S -0.611
INR_C:ALB_S -0.599
IL6_S:CA_S -0.586
CRP_S:ALB_S -0.576
IL6_S:BILID_S 0.575
CHOLG_S:CHE_S 0.571
CRP_S:CHE_S -0.564
CA_S:BILID_S -0.563
GGT_S:AP_S 0.562
INR_C:CHOLG_S -0.553
INR_C:IL6_S 0.553
BILID_S:ASAT_S 0.548
CYSC_S:CHE_S -0.543
INR_C:CA_S -0.529
IL6_S:BILI_S 0.527
PROT_S:CA_S 0.525
BILI_S:ASAT_S 0.519
PROT_S:ALB_S 0.511
PALB_S:CHOLG_S 0.502
CYSC_S:CRP_S 0.499
CA_S:BILI_S -0.497
CHOLG_S:CA_S 0.492
PALB_S:CRP_S -0.490
CRP_S:BILID_S 0.486
IL6_S:CHOLG_S -0.479
CYSC_S:ALB_S -0.475
CRP_S:CA_S -0.460
NA_S:CHE_S 0.453
PROT_S:CHE_S 0.452
ASAT_S:AP_S 0.445
CRP_S:BILI_S 0.438
NA_S:IL6_S -0.431
PROT_S:BILID_S -0.426
CHOLG_S:ALB_S 0.422
PALB_S:B_PLT_E 0.421
ASAT_S:ALB_S -0.414
PROT_S:BILI_S -0.412
BILID_S:B_PLT_E -0.410
INR_C:B_PLT_E -0.409
INR_C:CRP_S 0.408
PROT_S:CHOLG_S 0.406
B_WBC_E:B_PLT_E 0.405
BILI_S:B_PLT_E -0.397
CHOLG_S:BILID_S -0.396
PROT_S:IL6_S -0.392
VDT_OH_S:IL6_S -0.385
INR_C:ASAT_S 0.384
CYSC_S:BILID_S 0.384
CHOLG_S:BILI_S -0.382
PTH_S:CRE_S 0.377
NA_S:ALB_S 0.368
NA_S:CRP_S -0.365
CHE_S:ASAT_S -0.361
PROT_S:INR_C -0.359
PTH_S:CYSC_S 0.352
INR_C:CYSC_S 0.349
PALB_S:NA_S 0.348
IL6_S:CRE_S 0.344
PROT_S:PALB_S 0.344
CA_S:B_PLT_E 0.340
CHOLG_S:B_PLT_E 0.339
CRP_S:AP_S 0.338
CYSC_S:BILI_S 0.337
CHE_S:B_PLT_E 0.337
GGT_S:ASAT_S 0.336
CYSC_S:CA_S -0.335
CYSC_S:CHOLG_S -0.330
VDT_OH_S:CHE_S 0.329
NA_S:CYSC_S -0.327
NA_S:INR_C -0.327
PALB_S:ASAT_S -0.326
AP_S:ALB_S -0.325
PROT_S:CYSC_S -0.324
NA_S:BILID_S -0.324
B_PLT_E:ALB_S 0.323
CRP_S:ASAT_S 0.322
NA_S:CA_S 0.320
VDT_OH_S:PALB_S 0.312
IL6_S:ASAT_S 0.311
CRP_S:CHOLG_S -0.309
VDT_OH_S:CRP_S -0.306
VDT_OH_S:CA_S 0.303
NA_S:BILI_S -0.301
CRP_S:B_WBC_E 0.301
PALB_S:CYSC_S -0.300
VDT_OH_S:PTH_S -0.300
PROT_S:CRP_S -0.299
B_PLT_E:B_MPV_E -0.299
GGT_S:ALAT_S 0.298
GGT_S:CHOLG_S 0.297
CA_S:ASAT_S -0.296
VDT_OH_S:INR_C -0.292
BILID_S:AP_S 0.290
VDT_OH_S:ALB_S 0.286
CRP_S:CRE_S 0.286
VDT_OH_S:CYSC_S -0.283
VDT_OH_S:CHOLG_S 0.276
PROT_S:B_PLT_E 0.270
P_S:B_PLT_E 0.264
AP_S:ALAT_S 0.260
CRP_S:CL_S -0.260
PROT_S:CRE_S -0.259
CRE_S:CHE_S -0.257
CHE_S:AP_S -0.252
CL_S:B_WBC_E -0.249
PTH_S:CA_S -0.245
IL6_S:AP_S 0.244
IL6_S:CL_S -0.244
NA_S:CHOLG_S 0.243
VDT_OH_S:BILID_S -0.235
IL6_S:B_WBC_E 0.232
P_S:CRE_S 0.230
NA_S:CRE_S -0.224
CA_S:AP_S -0.220
GGT_S:CRP_S 0.219
CRE_S:B_WBC_E 0.218
CRE_S:ALB_S -0.216
VDT_OH_S:BILI_S -0.215
PTH_S:IL6_S 0.210
BILI_S:AP_S 0.210
CL_S:B_MPV_E 0.208
VDT_OH_S:PROT_S 0.208
PALB_S:AP_S -0.203
P_S:B_WBC_E 0.194
NA_S:AP_S -0.191
IL6_S:B_PLT_E -0.190
VDT_OH_S:NA_S 0.188
CYSC_S:AP_S 0.185
CYSC_S:B_WBC_E 0.181
NA_S:B_WBC_E -0.179
B_PLT_E:ASAT_S -0.178
PTH_S:CRP_S 0.174
NA_S:B_MPV_E 0.173
P_S:CYSC_S 0.172
CL_S:CHE_S 0.169
BILI_S:ALAT_S 0.167
GGT_S:B_PLT_E 0.166
CYSC_S:ASAT_S 0.165
NA_S:ASAT_S -0.163
BILID_S:ALAT_S 0.162
VDT_OH_S:B_WBC_E -0.161
CL_S:BILI_S -0.161
CYSC_S:ALAT_S -0.159
PALB_S:P_S 0.159
PTH_S:PROT_S -0.156
CRE_S:CHOLG_S -0.153
PROT_S:ASAT_S -0.146
VDT_OH_S:AP_S -0.146
PTH_S:AP_S 0.145
CRE_S:CA_S -0.144
B_MPV_E:ALAT_S 0.144
PTH_S:CHE_S -0.144
P_S:CA_S 0.141
CL_S:BILID_S -0.141
INR_C:GGT_S -0.140
CYSC_S:CL_S -0.138
VDT_OH_S:ASAT_S -0.136
CRE_S:BILID_S 0.133
CL_S:B_PLT_E -0.132
PTH_S:CHOLG_S -0.130
PROT_S:CL_S -0.128
PROT_S:GGT_S 0.128
P_S:INR_C -0.127
PALB_S:GGT_S 0.127
PTH_S:B_WBC_E 0.124
CHOLG_S:ASAT_S -0.124
CL_S:AP_S -0.124
CRE_S:ALAT_S -0.124
P_S:BILI_S -0.121
PALB_S:CL_S 0.120
B_WBC_E:B_MPV_E -0.118
INR_C:CL_S -0.117
P_S:BILID_S -0.115
INR_C:CRE_S 0.111
B_MPV_E:ASAT_S 0.110
PTH_S:GGT_S 0.110
VDT_OH_S:CRE_S -0.109
GGT_S:B_WBC_E 0.103
CRE_S:BILI_S 0.101
B_WBC_E:ASAT_S 0.098
P_S:CL_S -0.098
B_WBC_E:AP_S 0.098
P_S:ALB_S 0.097
CYSC_S:B_PLT_E -0.095
VDT_OH_S:CL_S 0.093
INR_C:AP_S 0.093
B_WBC_E:ALAT_S 0.091
PTH_S:NA_S -0.091
BILID_S:B_MPV_E 0.087
PALB_S:B_WBC_E 0.085
CL_S:ALB_S 0.082
IL6_S:B_MPV_E -0.081
CRP_S:B_MPV_E -0.081
CRE_S:CL_S -0.080
PALB_S:B_MPV_E -0.079
IL6_S:ALAT_S -0.078
NA_S:GGT_S -0.077
PTH_S:CL_S -0.073
P_S:CHOLG_S 0.073
PTH_S:ALB_S -0.073
P_S:NA_S -0.072
P_S:B_MPV_E -0.072
CHOLG_S:ALAT_S 0.072
CL_S:ASAT_S -0.070
BILI_S:B_MPV_E 0.069
B_PLT_E:ALAT_S -0.069
CHOLG_S:AP_S 0.068
CHE_S:ALAT_S 0.068
VDT_OH_S:ALAT_S 0.066
VDT_OH_S:B_MPV_E 0.066
PROT_S:B_WBC_E -0.065
PROT_S:P_S 0.065
PTH_S:ASAT_S 0.064
P_S:GGT_S 0.063
PTH_S:ALAT_S -0.062
B_MPV_E:AP_S 0.061
P_S:ALAT_S -0.060
P_S:AP_S 0.060
PROT_S:B_MPV_E -0.059
B_PLT_E:AP_S 0.059
PTH_S:BILID_S 0.058
PTH_S:INR_C 0.057
CRP_S:B_PLT_E -0.056
PROT_S:NA_S 0.056
VDT_OH_S:GGT_S -0.056
PTH_S:B_MPV_E -0.055
GGT_S:B_MPV_E 0.055
INR_C:ALAT_S 0.053
GGT_S:CL_S -0.052
PTH_S:BILI_S 0.048
CRP_S:ALAT_S 0.047
CL_S:CA_S 0.046
CRE_S:B_PLT_E 0.045
GGT_S:CYSC_S 0.045
P_S:CHE_S 0.043
BILID_S:B_WBC_E 0.042
P_S:ASAT_S -0.040
PROT_S:AP_S -0.040
CRE_S:AP_S 0.039
B_MPV_E:ALB_S -0.039
IL6_S:GGT_S 0.038
BILI_S:B_WBC_E 0.036
CA_S:B_MPV_E 0.036
PTH_S:B_PLT_E 0.035
ALB_S:ALAT_S -0.035
B_WBC_E:ALB_S -0.035
GGT_S:BILID_S 0.032
CRE_S:B_MPV_E -0.031
PALB_S:ALAT_S 0.031
PALB_S:CRE_S -0.030
GGT_S:BILI_S -0.029
VDT_OH_S:P_S -0.028
GGT_S:ALB_S -0.027
CHE_S:B_MPV_E 0.026
CA_S:B_WBC_E 0.021
CL_S:CHOLG_S 0.020
P_S:IL6_S -0.019
P_S:CRP_S -0.019
CHOLG_S:B_WBC_E 0.011
CHE_S:B_WBC_E -0.010
GGT_S:CA_S -0.010
CRE_S:ASAT_S 0.009
NA_S:B_PLT_E 0.009
NA_S:ALAT_S 0.009
CA_S:ALAT_S -0.009
CYSC_S:B_MPV_E -0.006
INR_C:B_MPV_E -0.006
CL_S:ALAT_S 0.006
PTH_S:PALB_S -0.006
INR_C:B_WBC_E 0.005
GGT_S:CRE_S 0.004
CHOLG_S:B_MPV_E 0.003
GGT_S:CHE_S 0.003
PTH_S:P_S -0.001
PROT_S:ALAT_S 0.001
VDT_OH_S:B_PLT_E 0.000

sessionInfo()
R version 4.2.0 (2022-04-22)
Platform: x86_64-unknown-linux-gnu (64-bit)

Matrix products: default
BLAS/LAPACK: /gnu/store/ras6dprsw3wm3swk23jjp8ww5dwxj333-openblas-0.3.18/lib/libopenblasp-r0.3.18.so

locale:
 [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C              
 [3] LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
 [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8   
 [7] LC_PAPER=en_US.UTF-8       LC_NAME=C                 
 [9] LC_ADDRESS=C               LC_TELEPHONE=C            
[11] LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
[1] targets_0.12.1 corrplot_0.92 

loaded via a namespace (and not attached):
 [1] Rcpp_1.0.8.3      highr_0.9         pillar_1.7.0      compiler_4.2.0   
 [5] bslib_0.3.1       later_1.3.0       jquerylib_0.1.4   git2r_0.30.1     
 [9] workflowr_1.7.0   tools_4.2.0       digest_0.6.29     jsonlite_1.8.0   
[13] evaluate_0.15     lifecycle_1.0.1   tibble_3.1.7      pkgconfig_2.0.3  
[17] rlang_1.0.2       igraph_1.3.1      cli_3.3.0         yaml_2.3.5       
[21] xfun_0.31         fastmap_1.1.0     withr_2.5.0       stringr_1.4.0    
[25] knitr_1.39        fs_1.5.2          vctrs_0.4.1       sass_0.4.1       
[29] tidyselect_1.1.2  rprojroot_2.0.3   data.table_1.14.2 glue_1.6.2       
[33] R6_2.5.1          processx_3.5.3    fansi_1.0.3       base64url_1.4    
[37] rmarkdown_2.14    bookdown_0.26     purrr_0.3.4       callr_3.7.0      
[41] magrittr_2.0.3    whisker_0.4       codetools_0.2-18  ps_1.7.0         
[45] backports_1.4.1   promises_1.2.0.1  ellipsis_0.3.2    htmltools_0.5.2  
[49] httpuv_1.6.5      utf8_1.2.2        stringi_1.7.6     crayon_1.5.1