GO_after_comments

Last updated: 2023-12-19

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Knit directory: Cardiotoxicity/

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    Modified:   analysis/DRC_analysis.Rmd
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    Modified:   output/veplot.RDS

Note that any generated files, e.g. HTML, png, CSS, etc., are not included in this status report because it is ok for generated content to have uncommitted changes.

These are the previous versions of the repository in which changes were made to the R Markdown (analysis/GO_after_comments.Rmd) and HTML (docs/GO_after_comments.html) files. If you’ve configured a remote Git repository (see ?wflow_git_remote), click on the hyperlinks in the table below to view the files as they were in that past version.

File	Version	Author	Date	Message
Rmd	cd8fd41	reneeisnowhere	2023-12-19	updates to figures and analysis
html	87685e2	reneeisnowhere	2023-12-19	Build site.
Rmd	e993745	reneeisnowhere	2023-12-19	Adding pathway enrichment plots
html	b442590	reneeisnowhere	2023-11-21	Build site.
Rmd	b464f89	reneeisnowhere	2023-11-21	updates to links again
html	fd6d33c	reneeisnowhere	2023-11-21	Build site.
Rmd	cbefbd1	reneeisnowhere	2023-11-21	adding links

library(tidyverse)
library(ggsignif)
library(cowplot)
library(ggpubr)
library(scales)
library(sjmisc)
library(kableExtra)
library(broom)
library(biomaRt)
library(RColorBrewer)
library(gprofiler2)
library(qvalue)

FC_mine <- readRDS("data/toplistall.RDS")
TRZ_list <- FC_mine %>% 
  filter(id=="TRZ",P.Value < 0.05) #%>% 
backGL <- read_csv("data/backGL.txt", 
    col_types = cols(...1 = col_skip()))

TRZ_list3h <- FC_mine %>% 
  filter(id=="TRZ",P.Value < 0.05, time == "3_hours")
TRZ_list24h <- FC_mine %>% 
  filter(id=="TRZ",P.Value < 0.05, time == "24_hours")

TRZ_listqvalue <- FC_mine %>% 
  filter(id=="TRZ", time=="24_hours") %>% 
  dplyr::select(ENTREZID,P.Value)

qobj <- qvalue(TRZ_listqvalue$P.Value)
hist(qobj)

Version	Author	Date
87685e2	reneeisnowhere	2023-12-19

plot(qobj)

Version	Author	Date
87685e2	reneeisnowhere	2023-12-19

TRZ nom de (3 & 24 hour)

# TRZresgenes <- gost(query = TRZ_list$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = TRUE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = backGL$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(TRZresgenes,"data/DEG-GO/TRZresgenes.RDS")
TRZresgenes <- readRDS("data/DEG-GO/TRZresgenes.RDS")

TRZnom <- gostplot(TRZresgenes, capped = FALSE, interactive = TRUE)
TRZnom

TRZnomtable <- TRZresgenes$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

TRZnomtable %>%
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:1902746	regulation of lens fiber cell differentiation	2	8	6.14e-02
GO:BP	GO:0098722	asymmetric stem cell division	1	2	6.14e-02
GO:BP	GO:0042078	germ-line stem cell division	1	2	6.14e-02
GO:BP	GO:0098728	germline stem cell asymmetric division	1	2	6.14e-02
GO:BP	GO:1902747	negative regulation of lens fiber cell differentiation	2	5	6.14e-02
GO:BP	GO:0048133	male germ-line stem cell asymmetric division	1	2	6.14e-02
GO:BP	GO:0035810	positive regulation of urine volume	2	10	6.14e-02
GO:BP	GO:0044849	estrous cycle	2	14	7.09e-02
GO:BP	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	2	15	8.54e-02
GO:BP	GO:1900745	positive regulation of p38MAPK cascade	2	22	8.66e-02
GO:BP	GO:0034599	cellular response to oxidative stress	3	218	8.66e-02
GO:BP	GO:1901386	negative regulation of voltage-gated calcium channel activity	2	14	8.66e-02
GO:BP	GO:0035809	regulation of urine volume	2	14	8.66e-02
GO:BP	GO:0030857	negative regulation of epithelial cell differentiation	2	31	9.28e-02
GO:BP	GO:0098708	glucose import across plasma membrane	1	5	9.28e-02
GO:BP	GO:0120162	positive regulation of cold-induced thermogenesis	3	72	9.28e-02
GO:BP	GO:0098739	import across plasma membrane	3	130	9.28e-02
GO:BP	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	2	28	9.28e-02
GO:BP	GO:0150104	transport across blood-brain barrier	2	72	9.28e-02
GO:BP	GO:0045210	FasL biosynthetic process	1	1	9.28e-02
GO:BP	GO:1900744	regulation of p38MAPK cascade	2	32	9.28e-02
GO:BP	GO:0098704	carbohydrate import across plasma membrane	1	5	9.28e-02
GO:BP	GO:1901385	regulation of voltage-gated calcium channel activity	2	29	9.28e-02
GO:BP	GO:0019249	lactate biosynthetic process	1	3	9.28e-02
GO:BP	GO:0018345	protein palmitoylation	1	30	9.28e-02
GO:BP	GO:0140271	hexose import across plasma membrane	1	5	9.28e-02
GO:BP	GO:0097167	circadian regulation of translation	1	4	9.28e-02
GO:BP	GO:0051764	actin crosslink formation	1	9	9.28e-02
GO:BP	GO:0070306	lens fiber cell differentiation	2	30	9.28e-02
GO:BP	GO:0043949	regulation of cAMP-mediated signaling	2	17	9.28e-02
GO:BP	GO:0007281	germ cell development	2	194	9.28e-02
GO:BP	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	1	7	9.28e-02
GO:BP	GO:0042918	alkanesulfonate transport	1	6	9.28e-02
GO:BP	GO:0048762	mesenchymal cell differentiation	4	205	9.28e-02
GO:BP	GO:0038066	p38MAPK cascade	2	42	9.28e-02
GO:BP	GO:0008356	asymmetric cell division	1	14	9.28e-02
GO:BP	GO:0036159	inner dynein arm assembly	1	8	9.28e-02
GO:BP	GO:0089718	amino acid import across plasma membrane	2	38	9.28e-02
GO:BP	GO:0051939	gamma-aminobutyric acid import	1	3	9.28e-02
GO:BP	GO:0051946	regulation of glutamate uptake involved in transmission of nerve impulse	1	3	9.28e-02
GO:BP	GO:0060251	regulation of glial cell proliferation	1	26	9.28e-02
GO:BP	GO:0060252	positive regulation of glial cell proliferation	1	14	9.28e-02
GO:BP	GO:0010719	negative regulation of epithelial to mesenchymal transition	2	29	9.28e-02
GO:BP	GO:0006979	response to oxidative stress	3	328	9.28e-02
GO:BP	GO:0060485	mesenchyme development	4	250	9.28e-02
GO:BP	GO:0061643	chemorepulsion of axon	1	6	9.28e-02
GO:BP	GO:0062197	cellular response to chemical stress	3	269	9.28e-02
GO:BP	GO:0051941	regulation of amino acid uptake involved in synaptic transmission	1	3	9.28e-02
GO:BP	GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	1	21	9.28e-02
GO:BP	GO:0022412	cellular process involved in reproduction in multicellular organism	2	255	9.28e-02
GO:BP	GO:1904059	regulation of locomotor rhythm	1	3	9.28e-02
GO:BP	GO:0010232	vascular transport	2	72	9.28e-02
GO:BP	GO:1990708	conditioned place preference	1	2	9.28e-02
GO:BP	GO:0015734	taurine transport	1	6	9.28e-02
GO:BP	GO:1904350	regulation of protein catabolic process in the vacuole	1	13	9.28e-02
GO:BP	GO:2001258	negative regulation of cation channel activity	2	31	9.28e-02
GO:BP	GO:0014015	positive regulation of gliogenesis	1	44	9.28e-02
GO:BP	GO:0001837	epithelial to mesenchymal transition	3	139	9.28e-02
GO:BP	GO:0014009	glial cell proliferation	1	40	9.28e-02
GO:BP	GO:1905165	regulation of lysosomal protein catabolic process	1	11	9.28e-02
GO:BP	GO:1903170	negative regulation of calcium ion transmembrane transport	2	35	9.28e-02
GO:BP	GO:0015757	galactose transmembrane transport	1	4	9.28e-02
GO:BP	GO:1904351	negative regulation of protein catabolic process in the vacuole	1	5	9.28e-02
GO:BP	GO:1902966	positive regulation of protein localization to early endosome	1	10	9.28e-02
GO:BP	GO:1902965	regulation of protein localization to early endosome	1	10	9.28e-02
GO:BP	GO:0017145	stem cell division	1	25	9.28e-02
GO:BP	GO:1902946	protein localization to early endosome	1	12	9.28e-02
GO:BP	GO:0003018	vascular process in circulatory system	3	198	9.28e-02
GO:BP	GO:0010799	regulation of peptidyl-threonine phosphorylation	2	35	9.28e-02
GO:BP	GO:0015800	acidic amino acid transport	2	39	9.28e-02
GO:BP	GO:0018230	peptidyl-L-cysteine S-palmitoylation	1	21	9.28e-02
GO:BP	GO:1905166	negative regulation of lysosomal protein catabolic process	1	5	9.28e-02
GO:BP	GO:0120161	regulation of cold-induced thermogenesis	3	115	9.49e-02
GO:BP	GO:0045226	extracellular polysaccharide biosynthetic process	1	2	9.49e-02
GO:BP	GO:1905668	positive regulation of protein localization to endosome	1	14	9.49e-02
GO:BP	GO:1900625	positive regulation of monocyte aggregation	1	3	9.49e-02
GO:BP	GO:0048232	male gamete generation	2	346	9.49e-02
GO:BP	GO:0046379	extracellular polysaccharide metabolic process	1	2	9.49e-02
GO:BP	GO:0007283	spermatogenesis	2	333	9.49e-02
GO:BP	GO:0007288	sperm axoneme assembly	1	20	9.49e-02
GO:BP	GO:1905666	regulation of protein localization to endosome	1	15	9.49e-02
GO:BP	GO:1900623	regulation of monocyte aggregation	1	3	9.49e-02
GO:BP	GO:0106106	cold-induced thermogenesis	3	116	9.54e-02
GO:BP	GO:0070345	negative regulation of fat cell proliferation	1	4	9.57e-02
GO:BP	GO:0045666	positive regulation of neuron differentiation	1	63	9.57e-02
GO:BP	GO:0018198	peptidyl-cysteine modification	1	41	9.57e-02
GO:BP	GO:0000379	tRNA-type intron splice site recognition and cleavage	1	3	9.96e-02
GO:BP	GO:0014013	regulation of gliogenesis	1	66	9.96e-02
GO:BP	GO:0003013	circulatory system process	4	445	1.04e-01
GO:BP	GO:0006044	N-acetylglucosamine metabolic process	1	16	1.04e-01
GO:BP	GO:0000271	polysaccharide biosynthetic process	2	54	1.04e-01
GO:BP	GO:0019933	cAMP-mediated signaling	2	35	1.04e-01
GO:BP	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway	1	3	1.04e-01
GO:BP	GO:1900127	positive regulation of hyaluronan biosynthetic process	1	4	1.04e-01
GO:BP	GO:1990845	adaptive thermogenesis	3	127	1.04e-01
GO:BP	GO:0003333	amino acid transmembrane transport	2	70	1.04e-01
GO:BP	GO:0015812	gamma-aminobutyric acid transport	1	11	1.04e-01
GO:BP	GO:0120316	sperm flagellum assembly	1	27	1.04e-01
GO:BP	GO:0070286	axonemal dynein complex assembly	1	21	1.04e-01
GO:BP	GO:0051935	glutamate reuptake	1	4	1.04e-01
GO:BP	GO:0070837	dehydroascorbic acid transport	1	7	1.04e-01
GO:BP	GO:0090500	endocardial cushion to mesenchymal transition	1	4	1.04e-01
GO:BP	GO:0032328	alanine transport	1	13	1.04e-01
GO:BP	GO:1905146	lysosomal protein catabolic process	1	19	1.04e-01
GO:BP	GO:0051926	negative regulation of calcium ion transport	2	45	1.05e-01
GO:BP	GO:0007276	gamete generation	2	465	1.05e-01
GO:BP	GO:0003351	epithelial cilium movement involved in extracellular fluid movement	1	30	1.05e-01
GO:BP	GO:0070373	negative regulation of ERK1 and ERK2 cascade	2	58	1.05e-01
GO:BP	GO:0034089	establishment of meiotic sister chromatid cohesion	1	4	1.05e-01
GO:BP	GO:0007039	protein catabolic process in the vacuole	1	22	1.07e-01
GO:BP	GO:0046330	positive regulation of JNK cascade	2	71	1.07e-01
GO:BP	GO:0006858	extracellular transport	1	33	1.07e-01
GO:BP	GO:0019852	L-ascorbic acid metabolic process	1	10	1.07e-01
GO:BP	GO:1901334	lactone metabolic process	1	10	1.07e-01
GO:BP	GO:0060437	lung growth	1	4	1.07e-01
GO:BP	GO:0042752	regulation of circadian rhythm	2	93	1.07e-01
GO:BP	GO:0010887	negative regulation of cholesterol storage	1	8	1.07e-01
GO:BP	GO:1901071	glucosamine-containing compound metabolic process	1	19	1.08e-01
GO:BP	GO:0070487	monocyte aggregation	1	4	1.08e-01
GO:BP	GO:0002036	regulation of L-glutamate import across plasma membrane	1	6	1.08e-01
GO:BP	GO:0042698	ovulation cycle	2	54	1.08e-01
GO:BP	GO:1901842	negative regulation of high voltage-gated calcium channel activity	1	4	1.09e-01
GO:BP	GO:0001659	temperature homeostasis	3	135	1.09e-01
GO:BP	GO:0036010	protein localization to endosome	1	28	1.16e-01
GO:BP	GO:0032413	negative regulation of ion transmembrane transporter activity	2	52	1.17e-01
GO:BP	GO:0048609	multicellular organismal reproductive process	2	538	1.17e-01
GO:BP	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	1	8	1.20e-01
GO:BP	GO:0070295	renal water absorption	1	6	1.20e-01
GO:BP	GO:0031397	negative regulation of protein ubiquitination	2	76	1.22e-01
GO:BP	GO:0051933	amino acid neurotransmitter reuptake	1	5	1.24e-01
GO:BP	GO:0070344	regulation of fat cell proliferation	1	8	1.24e-01
GO:BP	GO:0032504	multicellular organism reproduction	2	558	1.25e-01
GO:BP	GO:0006497	protein lipidation	1	89	1.25e-01
GO:BP	GO:0038003	G protein-coupled opioid receptor signaling pathway	1	5	1.25e-01
GO:BP	GO:0044458	motile cilium assembly	1	46	1.25e-01
GO:BP	GO:0031400	negative regulation of protein modification process	4	396	1.26e-01
GO:BP	GO:0050767	regulation of neurogenesis	3	302	1.26e-01
GO:BP	GO:0042158	lipoprotein biosynthetic process	1	92	1.26e-01
GO:BP	GO:0032410	negative regulation of transporter activity	2	59	1.26e-01
GO:BP	GO:0003006	developmental process involved in reproduction	2	603	1.26e-01
GO:BP	GO:0045664	regulation of neuron differentiation	1	137	1.26e-01
GO:BP	GO:1900125	regulation of hyaluronan biosynthetic process	1	6	1.26e-01
GO:BP	GO:0060449	bud elongation involved in lung branching	1	7	1.26e-01
GO:BP	GO:0002088	lens development in camera-type eye	2	57	1.27e-01
GO:BP	GO:0043951	negative regulation of cAMP-mediated signaling	1	10	1.33e-01
GO:BP	GO:0051382	kinetochore assembly	1	17	1.33e-01
GO:BP	GO:0042754	negative regulation of circadian rhythm	1	8	1.33e-01
GO:BP	GO:0050769	positive regulation of neurogenesis	1	190	1.33e-01
GO:BP	GO:0019953	sexual reproduction	2	633	1.33e-01
GO:BP	GO:1904063	negative regulation of cation transmembrane transport	2	64	1.33e-01
GO:BP	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	2	85	1.33e-01
GO:BP	GO:0032874	positive regulation of stress-activated MAPK cascade	2	95	1.33e-01
GO:BP	GO:0106070	regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	1	11	1.33e-01
GO:BP	GO:0006865	amino acid transport	2	103	1.33e-01
GO:BP	GO:1903321	negative regulation of protein modification by small protein conjugation or removal	2	86	1.33e-01
GO:BP	GO:0070304	positive regulation of stress-activated protein kinase signaling cascade	2	97	1.35e-01
GO:BP	GO:0006040	amino sugar metabolic process	1	34	1.36e-01
GO:BP	GO:0016202	regulation of striated muscle tissue development	1	13	1.36e-01
GO:BP	GO:0010885	regulation of cholesterol storage	1	13	1.36e-01
GO:BP	GO:0010717	regulation of epithelial to mesenchymal transition	2	87	1.36e-01
GO:BP	GO:1905039	carboxylic acid transmembrane transport	2	111	1.36e-01
GO:BP	GO:1903825	organic acid transmembrane transport	2	112	1.37e-01
GO:BP	GO:0003097	renal water transport	1	7	1.39e-01
GO:BP	GO:0045596	negative regulation of cell differentiation	5	471	1.39e-01
GO:BP	GO:0070341	fat cell proliferation	1	11	1.39e-01
GO:BP	GO:1901019	regulation of calcium ion transmembrane transporter activity	2	70	1.39e-01
GO:BP	GO:0045475	locomotor rhythm	1	13	1.39e-01
GO:BP	GO:0005976	polysaccharide metabolic process	2	81	1.39e-01
GO:BP	GO:0019935	cyclic-nucleotide-mediated signaling	2	52	1.39e-01
GO:BP	GO:0042157	lipoprotein metabolic process	1	116	1.40e-01
GO:BP	GO:0034766	negative regulation of monoatomic ion transmembrane transport	2	70	1.40e-01
GO:BP	GO:0051962	positive regulation of nervous system development	1	222	1.41e-01
GO:BP	GO:0051383	kinetochore organization	1	21	1.41e-01
GO:BP	GO:0000226	microtubule cytoskeleton organization	2	549	1.41e-01
GO:BP	GO:0046328	regulation of JNK cascade	2	113	1.41e-01
GO:BP	GO:0015711	organic anion transport	3	270	1.41e-01
GO:BP	GO:0045662	negative regulation of myoblast differentiation	1	20	1.41e-01
GO:BP	GO:0035082	axoneme assembly	1	54	1.41e-01
GO:BP	GO:0010958	regulation of amino acid import across plasma membrane	1	14	1.42e-01
GO:BP	GO:0051960	regulation of nervous system development	4	357	1.42e-01
GO:BP	GO:1903789	regulation of amino acid transmembrane transport	1	14	1.42e-01
GO:BP	GO:0018107	peptidyl-threonine phosphorylation	2	96	1.42e-01
GO:BP	GO:1901874	negative regulation of post-translational protein modification	2	98	1.45e-01
GO:BP	GO:0050435	amyloid-beta metabolic process	1	48	1.45e-01
GO:BP	GO:0010888	negative regulation of lipid storage	1	15	1.47e-01
GO:BP	GO:0098712	L-glutamate import across plasma membrane	1	11	1.47e-01
GO:BP	GO:0048634	regulation of muscle organ development	1	14	1.47e-01
GO:BP	GO:0034085	establishment of sister chromatid cohesion	1	10	1.49e-01
GO:BP	GO:0060349	bone morphogenesis	2	74	1.50e-01
GO:BP	GO:0048843	negative regulation of axon extension involved in axon guidance	1	26	1.50e-01
GO:BP	GO:0042063	gliogenesis	1	244	1.51e-01
GO:BP	GO:0050872	white fat cell differentiation	1	15	1.51e-01
GO:BP	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway	1	11	1.52e-01
GO:BP	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	1	8	1.52e-01
GO:BP	GO:0045595	regulation of cell differentiation	8	1122	1.52e-01
GO:BP	GO:0010878	cholesterol storage	1	18	1.52e-01
GO:BP	GO:0051580	regulation of neurotransmitter uptake	1	15	1.53e-01
GO:BP	GO:0018210	peptidyl-threonine modification	2	103	1.53e-01
GO:BP	GO:2000678	negative regulation of transcription regulatory region DNA binding	1	17	1.53e-01
GO:BP	GO:0051549	positive regulation of keratinocyte migration	1	11	1.53e-01
GO:BP	GO:0072348	sulfur compound transport	1	36	1.54e-01
GO:BP	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	1	33	1.57e-01
GO:BP	GO:0001933	negative regulation of protein phosphorylation	3	265	1.57e-01
GO:BP	GO:0006089	lactate metabolic process	1	16	1.57e-01
GO:BP	GO:0048511	rhythmic process	3	233	1.57e-01
GO:BP	GO:0001578	microtubule bundle formation	1	79	1.57e-01
GO:BP	GO:0070486	leukocyte aggregation	1	9	1.58e-01
GO:BP	GO:0030213	hyaluronan biosynthetic process	1	10	1.58e-01
GO:BP	GO:0036302	atrioventricular canal development	1	12	1.58e-01
GO:BP	GO:1901841	regulation of high voltage-gated calcium channel activity	1	12	1.62e-01
GO:BP	GO:0003014	renal system process	2	76	1.62e-01
GO:BP	GO:0015804	neutral amino acid transport	1	43	1.62e-01
GO:BP	GO:0048841	regulation of axon extension involved in axon guidance	1	31	1.62e-01
GO:BP	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus	1	10	1.62e-01
GO:BP	GO:0043543	protein acylation	1	193	1.62e-01
GO:BP	GO:0010838	positive regulation of keratinocyte proliferation	1	9	1.62e-01
GO:BP	GO:0097722	sperm motility	1	62	1.62e-01
GO:BP	GO:0034508	centromere complex assembly	1	29	1.62e-01
GO:BP	GO:0051547	regulation of keratinocyte migration	1	13	1.62e-01
GO:BP	GO:0030317	flagellated sperm motility	1	62	1.62e-01
GO:BP	GO:0043065	positive regulation of apoptotic process	4	394	1.63e-01
GO:BP	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	1	30	1.65e-01
GO:BP	GO:0007254	JNK cascade	2	137	1.65e-01
GO:BP	GO:0006836	neurotransmitter transport	2	141	1.65e-01
GO:BP	GO:0043620	regulation of DNA-templated transcription in response to stress	1	38	1.65e-01
GO:BP	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	1	13	1.65e-01
GO:BP	GO:0006487	protein N-linked glycosylation	1	65	1.65e-01
GO:BP	GO:0010720	positive regulation of cell development	1	318	1.65e-01
GO:BP	GO:0007623	circadian rhythm	2	160	1.65e-01
GO:BP	GO:0060294	cilium movement involved in cell motility	1	69	1.65e-01
GO:BP	GO:0001539	cilium or flagellum-dependent cell motility	1	72	1.66e-01
GO:BP	GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	1	14	1.66e-01
GO:BP	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	2	126	1.66e-01
GO:BP	GO:0043153	entrainment of circadian clock by photoperiod	1	23	1.66e-01
GO:BP	GO:0043068	positive regulation of programmed cell death	4	403	1.66e-01
GO:BP	GO:0048846	axon extension involved in axon guidance	1	35	1.66e-01
GO:BP	GO:0042326	negative regulation of phosphorylation	3	290	1.66e-01
GO:BP	GO:1902284	neuron projection extension involved in neuron projection guidance	1	35	1.66e-01
GO:BP	GO:0051177	meiotic sister chromatid cohesion	1	11	1.66e-01
GO:BP	GO:1901201	regulation of extracellular matrix assembly	1	15	1.66e-01
GO:BP	GO:0034763	negative regulation of transmembrane transport	2	96	1.66e-01
GO:BP	GO:0021591	ventricular system development	1	29	1.66e-01
GO:BP	GO:0022414	reproductive process	2	924	1.66e-01
GO:BP	GO:0055012	ventricular cardiac muscle cell differentiation	1	15	1.66e-01
GO:BP	GO:0043271	negative regulation of monoatomic ion transport	2	88	1.66e-01
GO:BP	GO:0060285	cilium-dependent cell motility	1	72	1.66e-01
GO:BP	GO:0000003	reproduction	2	933	1.66e-01
GO:BP	GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	2	127	1.68e-01
GO:BP	GO:0009648	photoperiodism	1	24	1.73e-01
GO:BP	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	1	16	1.73e-01
GO:BP	GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	2	122	1.73e-01
GO:BP	GO:0032872	regulation of stress-activated MAPK cascade	2	153	1.73e-01
GO:BP	GO:0001822	kidney development	3	246	1.74e-01
GO:BP	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	1	16	1.74e-01
GO:BP	GO:0070302	regulation of stress-activated protein kinase signaling cascade	2	157	1.78e-01
GO:BP	GO:0071526	semaphorin-plexin signaling pathway	1	44	1.78e-01
GO:BP	GO:0090181	regulation of cholesterol metabolic process	1	27	1.79e-01
GO:BP	GO:0009649	entrainment of circadian clock	1	27	1.79e-01
GO:BP	GO:0015813	L-glutamate transmembrane transport	1	18	1.79e-01
GO:BP	GO:0050919	negative chemotaxis	1	42	1.82e-01
GO:BP	GO:0030517	negative regulation of axon extension	1	41	1.82e-01
GO:BP	GO:0072001	renal system development	3	253	1.82e-01
GO:BP	GO:2001257	regulation of cation channel activity	2	100	1.83e-01
GO:BP	GO:0030856	regulation of epithelial cell differentiation	2	100	1.83e-01
GO:BP	GO:0060602	branch elongation of an epithelium	1	15	1.84e-01
GO:BP	GO:0007017	microtubule-based process	2	757	1.84e-01
GO:BP	GO:0051546	keratinocyte migration	1	15	1.86e-01
GO:BP	GO:0071498	cellular response to fluid shear stress	1	19	1.86e-01
GO:BP	GO:0043950	positive regulation of cAMP-mediated signaling	1	5	1.86e-01
GO:BP	GO:0003341	cilium movement	1	97	1.86e-01
GO:BP	GO:0010874	regulation of cholesterol efflux	1	31	1.86e-01
GO:BP	GO:0003417	growth plate cartilage development	1	14	1.88e-01
GO:BP	GO:0030010	establishment of cell polarity	2	135	1.88e-01
GO:BP	GO:0007286	spermatid development	1	108	1.88e-01
GO:BP	GO:0071174	mitotic spindle checkpoint signaling	1	43	1.91e-01
GO:BP	GO:0007094	mitotic spindle assembly checkpoint signaling	1	43	1.91e-01
GO:BP	GO:0036120	cellular response to platelet-derived growth factor stimulus	1	20	1.91e-01
GO:BP	GO:0071173	spindle assembly checkpoint signaling	1	43	1.91e-01
GO:BP	GO:0048515	spermatid differentiation	1	114	1.91e-01
GO:BP	GO:0099111	microtubule-based transport	1	192	1.92e-01
GO:BP	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	1	45	1.92e-01
GO:BP	GO:0009988	cell-cell recognition	1	31	1.92e-01
GO:BP	GO:1900746	regulation of vascular endothelial growth factor signaling pathway	1	18	1.92e-01
GO:BP	GO:0098810	neurotransmitter reuptake	1	21	1.92e-01
GO:BP	GO:0031577	spindle checkpoint signaling	1	44	1.92e-01
GO:BP	GO:1901861	regulation of muscle tissue development	1	34	1.92e-01
GO:BP	GO:0033046	negative regulation of sister chromatid segregation	1	45	1.92e-01
GO:BP	GO:0051180	vitamin transport	1	29	1.92e-01
GO:BP	GO:0042755	eating behavior	1	16	1.92e-01
GO:BP	GO:0033048	negative regulation of mitotic sister chromatid segregation	1	45	1.92e-01
GO:BP	GO:2000816	negative regulation of mitotic sister chromatid separation	1	45	1.92e-01
GO:BP	GO:0051301	cell division	1	569	1.93e-01
GO:BP	GO:0042177	negative regulation of protein catabolic process	1	100	1.93e-01
GO:BP	GO:0051938	L-glutamate import	1	24	1.94e-01
GO:BP	GO:1905819	negative regulation of chromosome separation	1	46	1.94e-01
GO:BP	GO:1902100	negative regulation of metaphase/anaphase transition of cell cycle	1	46	1.94e-01
GO:BP	GO:0051985	negative regulation of chromosome segregation	1	46	1.94e-01
GO:BP	GO:2000647	negative regulation of stem cell proliferation	1	18	1.94e-01
GO:BP	GO:0007517	muscle organ development	2	279	1.94e-01
GO:BP	GO:0036119	response to platelet-derived growth factor	1	22	1.94e-01
GO:BP	GO:0010563	negative regulation of phosphorus metabolic process	3	335	1.94e-01
GO:BP	GO:0021756	striatum development	1	18	1.94e-01
GO:BP	GO:0005996	monosaccharide metabolic process	2	212	1.94e-01
GO:BP	GO:0045936	negative regulation of phosphate metabolic process	3	334	1.94e-01
GO:BP	GO:0043409	negative regulation of MAPK cascade	2	145	1.94e-01
GO:BP	GO:0048011	neurotrophin TRK receptor signaling pathway	1	23	1.94e-01
GO:BP	GO:0001755	neural crest cell migration	1	49	1.94e-01
GO:BP	GO:1905953	negative regulation of lipid localization	1	31	1.94e-01
GO:BP	GO:0006612	protein targeting to membrane	1	120	1.94e-01
GO:BP	GO:1902547	regulation of cellular response to vascular endothelial growth factor stimulus	1	20	1.94e-01
GO:BP	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	2	71	1.94e-01
GO:BP	GO:0003091	renal water homeostasis	1	14	1.94e-01
GO:BP	GO:0043408	regulation of MAPK cascade	4	473	1.94e-01
GO:BP	GO:0090497	mesenchymal cell migration	1	51	1.95e-01
GO:BP	GO:0033047	regulation of mitotic sister chromatid segregation	1	51	1.97e-01
GO:BP	GO:0051783	regulation of nuclear division	2	115	1.97e-01
GO:BP	GO:0050922	negative regulation of chemotaxis	1	44	1.97e-01
GO:BP	GO:0035265	organ growth	2	128	1.98e-01
GO:BP	GO:0048512	circadian behavior	1	30	1.98e-01
GO:BP	GO:0051248	negative regulation of protein metabolic process	5	799	1.98e-01
GO:BP	GO:0051403	stress-activated MAPK cascade	2	188	1.99e-01
GO:BP	GO:0006767	water-soluble vitamin metabolic process	1	50	1.99e-01
GO:BP	GO:0045839	negative regulation of mitotic nuclear division	1	53	2.00e-01
GO:BP	GO:0010883	regulation of lipid storage	1	38	2.02e-01
GO:BP	GO:0007622	rhythmic behavior	1	32	2.03e-01
GO:BP	GO:0007130	synaptonemal complex assembly	1	10	2.03e-01
GO:BP	GO:0032331	negative regulation of chondrocyte differentiation	1	18	2.04e-01
GO:BP	GO:0050771	negative regulation of axonogenesis	1	59	2.05e-01
GO:BP	GO:0010965	regulation of mitotic sister chromatid separation	1	56	2.06e-01
GO:BP	GO:0045661	regulation of myoblast differentiation	1	60	2.06e-01
GO:BP	GO:0051955	regulation of amino acid transport	1	28	2.06e-01
GO:BP	GO:0031098	stress-activated protein kinase signaling cascade	2	194	2.06e-01
GO:BP	GO:0031345	negative regulation of cell projection organization	2	154	2.10e-01
GO:BP	GO:0034260	negative regulation of GTPase activity	1	25	2.10e-01
GO:BP	GO:0006833	water transport	1	12	2.11e-01
GO:BP	GO:0001504	neurotransmitter uptake	1	29	2.11e-01
GO:BP	GO:0009250	glucan biosynthetic process	1	40	2.11e-01
GO:BP	GO:0060441	epithelial tube branching involved in lung morphogenesis	1	21	2.11e-01
GO:BP	GO:0051784	negative regulation of nuclear division	1	56	2.11e-01
GO:BP	GO:0051306	mitotic sister chromatid separation	1	59	2.11e-01
GO:BP	GO:1901798	positive regulation of signal transduction by p53 class mediator	1	28	2.11e-01
GO:BP	GO:0005978	glycogen biosynthetic process	1	40	2.11e-01
GO:BP	GO:0060284	regulation of cell development	1	593	2.11e-01
GO:BP	GO:0045776	negative regulation of blood pressure	1	30	2.11e-01
GO:BP	GO:0051093	negative regulation of developmental process	5	654	2.11e-01
GO:BP	GO:0045597	positive regulation of cell differentiation	1	618	2.11e-01
GO:BP	GO:0044092	negative regulation of molecular function	5	730	2.12e-01
GO:BP	GO:0003416	endochondral bone growth	1	22	2.12e-01
GO:BP	GO:1903169	regulation of calcium ion transmembrane transport	2	120	2.12e-01
GO:BP	GO:0033344	cholesterol efflux	1	41	2.12e-01
GO:BP	GO:0070193	synaptonemal complex organization	1	13	2.12e-01
GO:BP	GO:0021544	subpallium development	1	19	2.12e-01
GO:BP	GO:0003401	axis elongation	1	25	2.12e-01
GO:BP	GO:0035116	embryonic hindlimb morphogenesis	1	17	2.12e-01
GO:BP	GO:0090162	establishment of epithelial cell polarity	1	30	2.13e-01
GO:BP	GO:0050890	cognition	2	226	2.13e-01
GO:BP	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	1	36	2.14e-01
GO:BP	GO:0070293	renal absorption	1	24	2.15e-01
GO:BP	GO:0043392	negative regulation of DNA binding	1	44	2.15e-01
GO:BP	GO:0006469	negative regulation of protein kinase activity	2	173	2.15e-01
GO:BP	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	1	25	2.15e-01
GO:BP	GO:0046323	glucose import	1	55	2.18e-01
GO:BP	GO:0001654	eye development	3	273	2.19e-01
GO:BP	GO:0061037	negative regulation of cartilage development	1	23	2.20e-01
GO:BP	GO:0060317	cardiac epithelial to mesenchymal transition	1	28	2.20e-01
GO:BP	GO:0030212	hyaluronan metabolic process	1	21	2.20e-01
GO:BP	GO:0007179	transforming growth factor beta receptor signaling pathway	2	177	2.20e-01
GO:BP	GO:0014032	neural crest cell development	1	70	2.20e-01
GO:BP	GO:0150063	visual system development	3	274	2.20e-01
GO:BP	GO:0032371	regulation of sterol transport	1	45	2.20e-01
GO:BP	GO:0032374	regulation of cholesterol transport	1	45	2.20e-01
GO:BP	GO:2000677	regulation of transcription regulatory region DNA binding	1	43	2.20e-01
GO:BP	GO:0050891	multicellular organismal-level water homeostasis	1	17	2.20e-01
GO:BP	GO:0098868	bone growth	1	23	2.20e-01
GO:BP	GO:0048880	sensory system development	3	276	2.24e-01
GO:BP	GO:0090150	establishment of protein localization to membrane	1	258	2.24e-01
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	1	744	2.24e-01
GO:BP	GO:0034405	response to fluid shear stress	1	31	2.24e-01
GO:BP	GO:1905818	regulation of chromosome separation	1	69	2.24e-01
GO:BP	GO:0048864	stem cell development	1	75	2.29e-01
GO:BP	GO:0048384	retinoic acid receptor signaling pathway	1	27	2.29e-01
GO:BP	GO:0048566	embryonic digestive tract development	1	20	2.29e-01
GO:BP	GO:0000132	establishment of mitotic spindle orientation	1	32	2.32e-01
GO:BP	GO:0032885	regulation of polysaccharide biosynthetic process	1	32	2.32e-01
GO:BP	GO:0031396	regulation of protein ubiquitination	2	194	2.32e-01
GO:BP	GO:0060351	cartilage development involved in endochondral bone morphogenesis	1	25	2.33e-01
GO:BP	GO:0016051	carbohydrate biosynthetic process	2	160	2.33e-01
GO:BP	GO:0000165	MAPK cascade	4	553	2.34e-01
GO:BP	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	1	36	2.35e-01
GO:BP	GO:0006605	protein targeting	1	310	2.36e-01
GO:BP	GO:0038179	neurotrophin signaling pathway	1	36	2.36e-01
GO:BP	GO:0002931	response to ischemia	1	48	2.36e-01
GO:BP	GO:0060271	cilium assembly	1	296	2.36e-01
GO:BP	GO:0042044	fluid transport	1	19	2.36e-01
GO:BP	GO:0014033	neural crest cell differentiation	1	79	2.36e-01
GO:BP	GO:0051304	chromosome separation	1	75	2.36e-01
GO:BP	GO:0048048	embryonic eye morphogenesis	1	25	2.36e-01
GO:BP	GO:0030516	regulation of axon extension	1	82	2.36e-01
GO:BP	GO:0007267	cell-cell signaling	5	1150	2.36e-01
GO:BP	GO:0033673	negative regulation of kinase activity	2	191	2.36e-01
GO:BP	GO:0043410	positive regulation of MAPK cascade	3	316	2.36e-01
GO:BP	GO:0002068	glandular epithelial cell development	1	28	2.36e-01
GO:BP	GO:0035137	hindlimb morphogenesis	1	21	2.36e-01
GO:BP	GO:0040020	regulation of meiotic nuclear division	1	19	2.36e-01
GO:BP	GO:0003008	system process	6	1194	2.38e-01
GO:BP	GO:0014911	positive regulation of smooth muscle cell migration	1	32	2.38e-01
GO:BP	GO:0046942	carboxylic acid transport	2	213	2.39e-01
GO:BP	GO:0140013	meiotic nuclear division	2	117	2.39e-01
GO:BP	GO:0098916	anterograde trans-synaptic signaling	2	490	2.39e-01
GO:BP	GO:0007268	chemical synaptic transmission	2	490	2.39e-01
GO:BP	GO:0015849	organic acid transport	2	214	2.39e-01
GO:BP	GO:0019229	regulation of vasoconstriction	1	38	2.40e-01
GO:BP	GO:0099537	trans-synaptic signaling	2	494	2.41e-01
GO:BP	GO:0045445	myoblast differentiation	1	90	2.43e-01
GO:BP	GO:0044782	cilium organization	1	317	2.43e-01
GO:BP	GO:0007163	establishment or maintenance of cell polarity	2	197	2.43e-01
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	9	1832	2.45e-01
GO:BP	GO:0032881	regulation of polysaccharide metabolic process	1	35	2.45e-01
GO:BP	GO:0085029	extracellular matrix assembly	1	36	2.45e-01
GO:BP	GO:0038084	vascular endothelial growth factor signaling pathway	1	35	2.45e-01
GO:BP	GO:0040001	establishment of mitotic spindle localization	1	37	2.45e-01
GO:BP	GO:0030071	regulation of mitotic metaphase/anaphase transition	1	87	2.45e-01
GO:BP	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	1	37	2.45e-01
GO:BP	GO:0090311	regulation of protein deacetylation	1	44	2.46e-01
GO:BP	GO:0035725	sodium ion transmembrane transport	1	112	2.46e-01
GO:BP	GO:0051294	establishment of spindle orientation	1	37	2.46e-01
GO:BP	GO:0099536	synaptic signaling	2	512	2.46e-01
GO:BP	GO:0007018	microtubule-based movement	1	300	2.46e-01
GO:BP	GO:0007010	cytoskeleton organization	2	1186	2.48e-01
GO:BP	GO:0051310	metaphase chromosome alignment	1	87	2.48e-01
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	1	918	2.48e-01
GO:BP	GO:1902099	regulation of metaphase/anaphase transition of cell cycle	1	88	2.48e-01
GO:BP	GO:1902475	L-alpha-amino acid transmembrane transport	1	51	2.48e-01
GO:BP	GO:0048640	negative regulation of developmental growth	1	94	2.48e-01
GO:BP	GO:0008284	positive regulation of cell population proliferation	1	886	2.48e-01
GO:BP	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	1	91	2.48e-01
GO:BP	GO:0060348	bone development	2	157	2.48e-01
GO:BP	GO:0050793	regulation of developmental process	5	1813	2.48e-01
GO:BP	GO:0061387	regulation of extent of cell growth	1	96	2.48e-01
GO:BP	GO:2001251	negative regulation of chromosome organization	1	89	2.48e-01
GO:BP	GO:0032922	circadian regulation of gene expression	1	63	2.48e-01
GO:BP	GO:0050795	regulation of behavior	1	41	2.50e-01
GO:BP	GO:0010837	regulation of keratinocyte proliferation	1	33	2.50e-01
GO:BP	GO:0044784	metaphase/anaphase transition of cell cycle	1	92	2.51e-01
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	1	1005	2.52e-01
GO:BP	GO:0051094	positive regulation of developmental process	1	957	2.52e-01
GO:BP	GO:0006486	protein glycosylation	1	185	2.52e-01
GO:BP	GO:0043413	macromolecule glycosylation	1	185	2.52e-01
GO:BP	GO:0060560	developmental growth involved in morphogenesis	2	207	2.52e-01
GO:BP	GO:0046580	negative regulation of Ras protein signal transduction	1	46	2.53e-01
GO:BP	GO:0042632	cholesterol homeostasis	1	58	2.53e-01
GO:BP	GO:0044042	glucan metabolic process	1	65	2.53e-01
GO:BP	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	1	37	2.53e-01
GO:BP	GO:0007264	small GTPase mediated signal transduction	3	413	2.53e-01
GO:BP	GO:0008037	cell recognition	1	82	2.53e-01
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	2	211	2.53e-01
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	5	707	2.53e-01
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	1	1014	2.53e-01
GO:BP	GO:0055092	sterol homeostasis	1	59	2.53e-01
GO:BP	GO:0005977	glycogen metabolic process	1	64	2.53e-01
GO:BP	GO:1903046	meiotic cell cycle process	2	132	2.53e-01
GO:BP	GO:0019915	lipid storage	1	68	2.53e-01
GO:BP	GO:0019233	sensory perception of pain	1	39	2.53e-01
GO:BP	GO:0051726	regulation of cell cycle	4	941	2.53e-01
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	3	445	2.53e-01
GO:BP	GO:0031641	regulation of myelination	1	35	2.53e-01
GO:BP	GO:1903320	regulation of protein modification by small protein conjugation or removal	2	232	2.53e-01
GO:BP	GO:0010389	regulation of G2/M transition of mitotic cell cycle	1	94	2.53e-01
GO:BP	GO:0006766	vitamin metabolic process	1	75	2.53e-01
GO:BP	GO:0000280	nuclear division	3	343	2.53e-01
GO:BP	GO:0033045	regulation of sister chromatid segregation	1	99	2.53e-01
GO:BP	GO:2000026	regulation of multicellular organismal development	1	997	2.53e-01
GO:BP	GO:0070085	glycosylation	1	197	2.53e-01
GO:BP	GO:1904659	glucose transmembrane transport	1	84	2.53e-01
GO:BP	GO:0032890	regulation of organic acid transport	1	48	2.53e-01
GO:BP	GO:0030182	neuron differentiation	1	1058	2.53e-01
GO:BP	GO:0051303	establishment of chromosome localization	1	93	2.54e-01
GO:BP	GO:0048705	skeletal system morphogenesis	2	155	2.54e-01
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	2	222	2.54e-01
GO:BP	GO:0051348	negative regulation of transferase activity	2	225	2.54e-01
GO:BP	GO:0051253	negative regulation of RNA metabolic process	1	1112	2.54e-01
GO:BP	GO:0008645	hexose transmembrane transport	1	87	2.54e-01
GO:BP	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	1	102	2.54e-01
GO:BP	GO:0019218	regulation of steroid metabolic process	1	68	2.54e-01
GO:BP	GO:0009101	glycoprotein biosynthetic process	2	251	2.54e-01
GO:BP	GO:0048675	axon extension	1	108	2.54e-01
GO:BP	GO:0060425	lung morphogenesis	1	39	2.57e-01
GO:BP	GO:0048468	cell development	2	1950	2.57e-01
GO:BP	GO:0015749	monosaccharide transmembrane transport	1	88	2.57e-01
GO:BP	GO:0008306	associative learning	1	65	2.57e-01
GO:BP	GO:0071559	response to transforming growth factor beta	2	227	2.58e-01
GO:BP	GO:0042310	vasoconstriction	1	51	2.58e-01
GO:BP	GO:0048699	generation of neurons	1	1120	2.59e-01
GO:BP	GO:1902749	regulation of cell cycle G2/M phase transition	1	105	2.61e-01
GO:BP	GO:0071702	organic substance transport	7	2133	2.61e-01
GO:BP	GO:0050000	chromosome localization	1	101	2.62e-01
GO:BP	GO:0014706	striated muscle tissue development	2	214	2.63e-01
GO:BP	GO:0030335	positive regulation of cell migration	3	408	2.63e-01
GO:BP	GO:0015807	L-amino acid transport	1	62	2.63e-01
GO:BP	GO:0002066	columnar/cuboidal epithelial cell development	1	39	2.65e-01
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	1	1203	2.66e-01
GO:BP	GO:0051058	negative regulation of small GTPase mediated signal transduction	1	52	2.66e-01
GO:BP	GO:0006094	gluconeogenesis	1	70	2.66e-01
GO:BP	GO:0006112	energy reserve metabolic process	1	72	2.66e-01
GO:BP	GO:0007088	regulation of mitotic nuclear division	1	99	2.66e-01
GO:BP	GO:0051924	regulation of calcium ion transport	2	167	2.66e-01
GO:BP	GO:0010977	negative regulation of neuron projection development	1	117	2.69e-01
GO:BP	GO:0043407	negative regulation of MAP kinase activity	1	50	2.69e-01
GO:BP	GO:0032330	regulation of chondrocyte differentiation	1	36	2.69e-01
GO:BP	GO:0034219	carbohydrate transmembrane transport	1	95	2.69e-01
GO:BP	GO:0072657	protein localization to membrane	1	530	2.69e-01
GO:BP	GO:1903053	regulation of extracellular matrix organization	1	47	2.70e-01
GO:BP	GO:0019319	hexose biosynthetic process	1	73	2.70e-01
GO:BP	GO:0043616	keratinocyte proliferation	1	39	2.70e-01
GO:BP	GO:0051240	positive regulation of multicellular organismal process	1	1103	2.72e-01
GO:BP	GO:0006814	sodium ion transport	1	158	2.73e-01
GO:BP	GO:0051293	establishment of spindle localization	1	49	2.73e-01
GO:BP	GO:0030301	cholesterol transport	1	81	2.73e-01
GO:BP	GO:0033554	cellular response to stress	7	1662	2.73e-01
GO:BP	GO:0120031	plasma membrane bounded cell projection assembly	1	463	2.73e-01
GO:BP	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	2	189	2.73e-01
GO:BP	GO:0006835	dicarboxylic acid transport	1	61	2.73e-01
GO:BP	GO:0050768	negative regulation of neurogenesis	1	113	2.73e-01
GO:BP	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	2	113	2.74e-01
GO:BP	GO:0007129	homologous chromosome pairing at meiosis	1	24	2.74e-01
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	1	1298	2.76e-01
GO:BP	GO:0022008	neurogenesis	1	1297	2.76e-01
GO:BP	GO:0051983	regulation of chromosome segregation	1	121	2.76e-01
GO:BP	GO:0007416	synapse assembly	1	153	2.76e-01
GO:BP	GO:0030031	cell projection assembly	1	473	2.76e-01
GO:BP	GO:0051588	regulation of neurotransmitter transport	1	71	2.76e-01
GO:BP	GO:1900024	regulation of substrate adhesion-dependent cell spreading	1	54	2.76e-01
GO:BP	GO:2000147	positive regulation of cell motility	3	421	2.76e-01
GO:BP	GO:0035924	cellular response to vascular endothelial growth factor stimulus	1	54	2.76e-01
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	1	1305	2.76e-01
GO:BP	GO:0051952	regulation of amine transport	1	56	2.77e-01
GO:BP	GO:0051961	negative regulation of nervous system development	1	119	2.78e-01
GO:BP	GO:0048285	organelle fission	3	387	2.78e-01
GO:BP	GO:0005975	carbohydrate metabolic process	3	439	2.80e-01
GO:BP	GO:0051668	localization within membrane	1	611	2.80e-01
GO:BP	GO:0051653	spindle localization	1	53	2.80e-01
GO:BP	GO:0050770	regulation of axonogenesis	1	139	2.80e-01
GO:BP	GO:0046364	monosaccharide biosynthetic process	1	82	2.80e-01
GO:BP	GO:0022898	regulation of transmembrane transporter activity	2	200	2.80e-01
GO:BP	GO:0007062	sister chromatid cohesion	1	52	2.80e-01
GO:BP	GO:0007631	feeding behavior	1	51	2.80e-01
GO:BP	GO:0040017	positive regulation of locomotion	3	429	2.82e-01
GO:BP	GO:0070372	regulation of ERK1 and ERK2 cascade	2	192	2.82e-01
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	2	249	2.83e-01
GO:BP	GO:0000086	G2/M transition of mitotic cell cycle	1	130	2.83e-01
GO:BP	GO:0060350	endochondral bone morphogenesis	1	47	2.84e-01
GO:BP	GO:0051254	positive regulation of RNA metabolic process	1	1425	2.86e-01
GO:BP	GO:0007218	neuropeptide signaling pathway	1	36	2.86e-01
GO:BP	GO:0015918	sterol transport	1	93	2.86e-01
GO:BP	GO:0014910	regulation of smooth muscle cell migration	1	57	2.86e-01
GO:BP	GO:1902531	regulation of intracellular signal transduction	7	1318	2.87e-01
GO:BP	GO:0007093	mitotic cell cycle checkpoint signaling	1	137	2.87e-01
GO:BP	GO:0008643	carbohydrate transport	1	114	2.88e-01
GO:BP	GO:0098657	import into cell	3	664	2.92e-01
GO:BP	GO:0015837	amine transport	1	59	2.92e-01
GO:BP	GO:0032355	response to estradiol	1	79	2.92e-01
GO:BP	GO:0080135	regulation of cellular response to stress	3	585	2.92e-01
GO:BP	GO:0008283	cell population proliferation	2	2340	2.94e-01
GO:BP	GO:0009895	negative regulation of catabolic process	1	287	2.94e-01
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	2	261	2.94e-01
GO:BP	GO:0008285	negative regulation of cell population proliferation	4	643	2.97e-01
GO:BP	GO:0030330	DNA damage response, signal transduction by p53 class mediator	1	70	2.97e-01
GO:BP	GO:0032409	regulation of transporter activity	2	212	2.97e-01
GO:BP	GO:0030334	regulation of cell migration	4	707	2.98e-01
GO:BP	GO:0006024	glycosaminoglycan biosynthetic process	1	59	2.98e-01
GO:BP	GO:0090596	sensory organ morphogenesis	2	179	2.98e-01
GO:BP	GO:0051480	regulation of cytosolic calcium ion concentration	1	39	2.98e-01
GO:BP	GO:0032368	regulation of lipid transport	1	91	2.98e-01
GO:BP	GO:0045143	homologous chromosome segregation	1	32	2.98e-01
GO:BP	GO:0044839	cell cycle G2/M phase transition	1	145	2.99e-01
GO:BP	GO:0008203	cholesterol metabolic process	1	99	2.99e-01
GO:BP	GO:0070192	chromosome organization involved in meiotic cell cycle	1	35	3.00e-01
GO:BP	GO:0061061	muscle structure development	2	552	3.00e-01
GO:BP	GO:0006023	aminoglycan biosynthetic process	1	61	3.00e-01
GO:BP	GO:0070371	ERK1 and ERK2 cascade	2	211	3.00e-01
GO:BP	GO:1990138	neuron projection extension	1	149	3.00e-01
GO:BP	GO:0014909	smooth muscle cell migration	1	64	3.00e-01
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	1	1589	3.00e-01
GO:BP	GO:0042176	regulation of protein catabolic process	1	328	3.00e-01
GO:BP	GO:0034762	regulation of transmembrane transport	3	392	3.00e-01
GO:BP	GO:0009100	glycoprotein metabolic process	2	315	3.01e-01
GO:BP	GO:0140962	multicellular organismal-level chemical homeostasis	1	48	3.01e-01
GO:BP	GO:0051445	regulation of meiotic cell cycle	1	45	3.02e-01
GO:BP	GO:0018193	peptidyl-amino acid modification	1	866	3.02e-01
GO:BP	GO:1901873	regulation of post-translational protein modification	2	302	3.04e-01
GO:BP	GO:0006476	protein deacetylation	1	81	3.04e-01
GO:BP	GO:0048562	embryonic organ morphogenesis	2	186	3.04e-01
GO:BP	GO:0006886	intracellular protein transport	1	803	3.04e-01
GO:BP	GO:0048871	multicellular organismal-level homeostasis	4	570	3.04e-01
GO:BP	GO:1902652	secondary alcohol metabolic process	1	106	3.04e-01
GO:BP	GO:0030308	negative regulation of cell growth	1	161	3.04e-01
GO:BP	GO:0008361	regulation of cell size	1	160	3.04e-01
GO:BP	GO:0008543	fibroblast growth factor receptor signaling pathway	1	59	3.04e-01
GO:BP	GO:0051101	regulation of DNA binding	1	102	3.04e-01
GO:BP	GO:0061035	regulation of cartilage development	1	53	3.04e-01
GO:BP	GO:0045913	positive regulation of carbohydrate metabolic process	1	61	3.04e-01
GO:BP	GO:0007015	actin filament organization	1	372	3.04e-01
GO:BP	GO:0008015	blood circulation	2	372	3.04e-01
GO:BP	GO:0090066	regulation of anatomical structure size	2	395	3.04e-01
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	1	114	3.04e-01
GO:BP	GO:0042127	regulation of cell population proliferation	1	1568	3.09e-01
GO:BP	GO:0002067	glandular epithelial cell differentiation	1	49	3.09e-01
GO:BP	GO:0051321	meiotic cell cycle	2	183	3.11e-01
GO:BP	GO:0048870	cell motility	2	1169	3.12e-01
GO:BP	GO:0016125	sterol metabolic process	1	108	3.12e-01
GO:BP	GO:0051129	negative regulation of cellular component organization	2	592	3.13e-01
GO:BP	GO:0008277	regulation of G protein-coupled receptor signaling pathway	1	93	3.14e-01
GO:BP	GO:0001570	vasculogenesis	1	67	3.22e-01
GO:BP	GO:0007423	sensory organ development	3	395	3.22e-01
GO:BP	GO:1901991	negative regulation of mitotic cell cycle phase transition	1	165	3.22e-01
GO:BP	GO:0019932	second-messenger-mediated signaling	2	182	3.23e-01
GO:BP	GO:2000145	regulation of cell motility	4	741	3.23e-01
GO:BP	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	1	165	3.23e-01
GO:BP	GO:0055085	transmembrane transport	4	1014	3.23e-01
GO:BP	GO:0043010	camera-type eye development	2	237	3.23e-01
GO:BP	GO:0055088	lipid homeostasis	1	116	3.25e-01
GO:BP	GO:1905952	regulation of lipid localization	1	110	3.25e-01
GO:BP	GO:0014812	muscle cell migration	1	75	3.25e-01
GO:BP	GO:0098813	nuclear chromosome segregation	2	264	3.28e-01
GO:BP	GO:0035601	protein deacylation	1	91	3.28e-01
GO:BP	GO:0000070	mitotic sister chromatid segregation	1	178	3.28e-01
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	2	232	3.28e-01
GO:BP	GO:0007049	cell cycle	7	1515	3.29e-01
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	1	1764	3.29e-01
GO:BP	GO:0098732	macromolecule deacylation	1	92	3.29e-01
GO:BP	GO:1901137	carbohydrate derivative biosynthetic process	3	544	3.29e-01
GO:BP	GO:0043087	regulation of GTPase activity	2	288	3.31e-01
GO:BP	GO:0097746	blood vessel diameter maintenance	1	98	3.33e-01
GO:BP	GO:0035296	regulation of tube diameter	1	98	3.33e-01
GO:BP	GO:0050920	regulation of chemotaxis	1	143	3.33e-01
GO:BP	GO:0000075	cell cycle checkpoint signaling	1	184	3.33e-01
GO:BP	GO:0035150	regulation of tube size	1	98	3.34e-01
GO:BP	GO:0006366	transcription by RNA polymerase II	1	1852	3.36e-01
GO:BP	GO:1901615	organic hydroxy compound metabolic process	2	375	3.36e-01
GO:BP	GO:0071897	DNA biosynthetic process	1	174	3.36e-01
GO:BP	GO:1901566	organonitrogen compound biosynthetic process	2	1496	3.36e-01
GO:BP	GO:0048869	cellular developmental process	13	2943	3.36e-01
GO:BP	GO:0007399	nervous system development	1	1886	3.36e-01
GO:BP	GO:0030154	cell differentiation	13	2942	3.36e-01
GO:BP	GO:0007612	learning	1	114	3.36e-01
GO:BP	GO:0048588	developmental cell growth	1	194	3.37e-01
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	2	298	3.38e-01
GO:BP	GO:0071363	cellular response to growth factor stimulus	3	549	3.38e-01
GO:BP	GO:0072091	regulation of stem cell proliferation	1	58	3.38e-01
GO:BP	GO:0040012	regulation of locomotion	4	762	3.39e-01
GO:BP	GO:0007411	axon guidance	1	177	3.43e-01
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	1	1896	3.43e-01
GO:BP	GO:0097485	neuron projection guidance	1	177	3.43e-01
GO:BP	GO:1903510	mucopolysaccharide metabolic process	1	75	3.43e-01
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	1	140	3.43e-01
GO:BP	GO:0050878	regulation of body fluid levels	2	237	3.43e-01
GO:BP	GO:0045132	meiotic chromosome segregation	1	51	3.43e-01
GO:BP	GO:1903829	positive regulation of protein localization	1	392	3.44e-01
GO:BP	GO:0016525	negative regulation of angiogenesis	1	71	3.44e-01
GO:BP	GO:0070588	calcium ion transmembrane transport	2	221	3.44e-01
GO:BP	GO:1901796	regulation of signal transduction by p53 class mediator	1	102	3.45e-01
GO:BP	GO:0048589	developmental growth	3	522	3.46e-01
GO:BP	GO:0009891	positive regulation of biosynthetic process	1	1972	3.46e-01
GO:BP	GO:0048863	stem cell differentiation	1	196	3.46e-01
GO:BP	GO:0090288	negative regulation of cellular response to growth factor stimulus	1	80	3.46e-01
GO:BP	GO:0043255	regulation of carbohydrate biosynthetic process	1	79	3.46e-01
GO:BP	GO:0070887	cellular response to chemical stimulus	1	1857	3.46e-01
GO:BP	GO:0045926	negative regulation of growth	1	204	3.46e-01
GO:BP	GO:2000181	negative regulation of blood vessel morphogenesis	1	72	3.46e-01
GO:BP	GO:1901343	negative regulation of vasculature development	1	72	3.46e-01
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	1	1958	3.46e-01
GO:BP	GO:0034446	substrate adhesion-dependent cell spreading	1	90	3.46e-01
GO:BP	GO:0070925	organelle assembly	1	828	3.46e-01
GO:BP	GO:1990830	cellular response to leukemia inhibitory factor	1	86	3.46e-01
GO:BP	GO:0051100	negative regulation of binding	1	133	3.46e-01
GO:BP	GO:1990823	response to leukemia inhibitory factor	1	87	3.48e-01
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	1	1669	3.48e-01
GO:BP	GO:0033138	positive regulation of peptidyl-serine phosphorylation	1	68	3.52e-01
GO:BP	GO:0070848	response to growth factor	3	571	3.52e-01
GO:BP	GO:0044344	cellular response to fibroblast growth factor stimulus	1	81	3.52e-01
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	1	1708	3.52e-01
GO:BP	GO:0042472	inner ear morphogenesis	1	59	3.53e-01
GO:BP	GO:0071901	negative regulation of protein serine/threonine kinase activity	1	96	3.53e-01
GO:BP	GO:0009890	negative regulation of biosynthetic process	1	1721	3.53e-01
GO:BP	GO:0071347	cellular response to interleukin-1	1	64	3.57e-01
GO:BP	GO:0001657	ureteric bud development	1	75	3.58e-01
GO:BP	GO:0045930	negative regulation of mitotic cell cycle	1	209	3.58e-01
GO:BP	GO:0000819	sister chromatid segregation	1	217	3.59e-01
GO:BP	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	1	78	3.59e-01
GO:BP	GO:0072163	mesonephric epithelium development	1	76	3.59e-01
GO:BP	GO:0072164	mesonephric tubule development	1	76	3.59e-01
GO:BP	GO:0050796	regulation of insulin secretion	1	119	3.61e-01
GO:BP	GO:0035556	intracellular signal transduction	9	2036	3.65e-01
GO:BP	GO:0010721	negative regulation of cell development	1	190	3.66e-01
GO:BP	GO:0008217	regulation of blood pressure	1	114	3.66e-01
GO:BP	GO:0051239	regulation of multicellular organismal process	1	2052	3.66e-01
GO:BP	GO:0071774	response to fibroblast growth factor	1	85	3.66e-01
GO:BP	GO:0065004	protein-DNA complex assembly	1	171	3.67e-01
GO:BP	GO:0001823	mesonephros development	1	77	3.67e-01
GO:BP	GO:0030036	actin cytoskeleton organization	1	566	3.76e-01
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	1	2367	3.76e-01
GO:BP	GO:0030203	glycosaminoglycan metabolic process	1	87	3.77e-01
GO:BP	GO:0050804	modulation of chemical synaptic transmission	1	343	3.79e-01
GO:BP	GO:0099177	regulation of trans-synaptic signaling	1	344	3.79e-01
GO:BP	GO:0001505	regulation of neurotransmitter levels	1	132	3.80e-01
GO:BP	GO:0033044	regulation of chromosome organization	1	235	3.80e-01
GO:BP	GO:0010959	regulation of metal ion transport	2	271	3.82e-01
GO:BP	GO:0006006	glucose metabolic process	1	153	3.84e-01
GO:BP	GO:1901988	negative regulation of cell cycle phase transition	1	234	3.86e-01
GO:BP	GO:0016567	protein ubiquitination	3	684	3.90e-01
GO:BP	GO:0031324	negative regulation of cellular metabolic process	1	2069	3.91e-01
GO:BP	GO:0055007	cardiac muscle cell differentiation	1	108	3.91e-01
GO:BP	GO:0010811	positive regulation of cell-substrate adhesion	1	99	3.94e-01
GO:BP	GO:0002062	chondrocyte differentiation	1	89	3.94e-01
GO:BP	GO:0030855	epithelial cell differentiation	3	439	3.94e-01
GO:BP	GO:0042471	ear morphogenesis	1	73	3.94e-01
GO:BP	GO:0006022	aminoglycan metabolic process	1	92	3.95e-01
GO:BP	GO:0006936	muscle contraction	1	266	3.95e-01
GO:BP	GO:0001667	ameboidal-type cell migration	2	358	3.97e-01
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	1	2131	3.97e-01
GO:BP	GO:0007626	locomotory behavior	1	139	3.97e-01
GO:BP	GO:0072089	stem cell proliferation	1	84	3.97e-01
GO:BP	GO:0048638	regulation of developmental growth	1	254	3.99e-01
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	1	80	3.99e-01
GO:BP	GO:0090276	regulation of peptide hormone secretion	1	135	3.99e-01
GO:BP	GO:0015031	protein transport	1	1366	4.00e-01
GO:BP	GO:0046907	intracellular transport	1	1440	4.00e-01
GO:BP	GO:0030073	insulin secretion	1	144	4.01e-01
GO:BP	GO:0030029	actin filament-based process	1	643	4.01e-01
GO:BP	GO:0002791	regulation of peptide secretion	1	137	4.01e-01
GO:BP	GO:0031325	positive regulation of cellular metabolic process	1	2518	4.01e-01
GO:BP	GO:0140014	mitotic nuclear division	1	251	4.01e-01
GO:BP	GO:0030326	embryonic limb morphogenesis	1	89	4.01e-01
GO:BP	GO:0035113	embryonic appendage morphogenesis	1	89	4.01e-01
GO:BP	GO:0090087	regulation of peptide transport	1	139	4.01e-01
GO:BP	GO:0006355	regulation of DNA-templated transcription	1	2560	4.01e-01
GO:BP	GO:0034502	protein localization to chromosome	1	101	4.02e-01
GO:BP	GO:0070555	response to interleukin-1	1	82	4.02e-01
GO:BP	GO:0060537	muscle tissue development	2	347	4.02e-01
GO:BP	GO:2001141	regulation of RNA biosynthetic process	1	2577	4.02e-01
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	1	2607	4.04e-01
GO:BP	GO:0051051	negative regulation of transport	2	317	4.05e-01
GO:BP	GO:0051241	negative regulation of multicellular organismal process	4	744	4.05e-01
GO:BP	GO:0033135	regulation of peptidyl-serine phosphorylation	1	97	4.05e-01
GO:BP	GO:0042981	regulation of apoptotic process	5	1092	4.05e-01
GO:BP	GO:0040013	negative regulation of locomotion	1	262	4.05e-01
GO:BP	GO:0034329	cell junction assembly	1	347	4.06e-01
GO:BP	GO:0072330	monocarboxylic acid biosynthetic process	1	146	4.07e-01
GO:BP	GO:0043547	positive regulation of GTPase activity	1	211	4.07e-01
GO:BP	GO:0097435	supramolecular fiber organization	1	666	4.07e-01
GO:BP	GO:0009892	negative regulation of metabolic process	1	2297	4.07e-01
GO:BP	GO:0006351	DNA-templated transcription	1	2669	4.07e-01
GO:BP	GO:0045184	establishment of protein localization	1	1468	4.08e-01
GO:BP	GO:0051656	establishment of organelle localization	2	397	4.08e-01
GO:BP	GO:0032774	RNA biosynthetic process	1	2699	4.10e-01
GO:BP	GO:0007059	chromosome segregation	2	360	4.10e-01
GO:BP	GO:0048585	negative regulation of response to stimulus	5	1267	4.12e-01
GO:BP	GO:0010948	negative regulation of cell cycle process	1	271	4.12e-01
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	1	214	4.15e-01
GO:BP	GO:0007127	meiosis I	1	73	4.15e-01
GO:BP	GO:0006816	calcium ion transport	2	275	4.18e-01
GO:BP	GO:0048565	digestive tract development	1	92	4.19e-01
GO:BP	GO:0051252	regulation of RNA metabolic process	1	2824	4.22e-01
GO:BP	GO:0006810	transport	2	3294	4.24e-01
GO:BP	GO:0019318	hexose metabolic process	1	187	4.24e-01
GO:BP	GO:0050808	synapse organization	1	373	4.24e-01
GO:BP	GO:0043067	regulation of programmed cell death	5	1124	4.24e-01
GO:BP	GO:0009893	positive regulation of metabolic process	1	2846	4.25e-01
GO:BP	GO:0061982	meiosis I cell cycle process	1	77	4.26e-01
GO:BP	GO:0010634	positive regulation of epithelial cell migration	1	132	4.27e-01
GO:BP	GO:0045444	fat cell differentiation	1	187	4.27e-01
GO:BP	GO:0032535	regulation of cellular component size	1	306	4.27e-01
GO:BP	GO:0009968	negative regulation of signal transduction	4	1017	4.28e-01
GO:BP	GO:0040011	locomotion	4	854	4.28e-01
GO:BP	GO:0032446	protein modification by small protein conjugation	3	759	4.28e-01
GO:BP	GO:0048754	branching morphogenesis of an epithelial tube	1	121	4.28e-01
GO:BP	GO:0023051	regulation of signaling	9	2560	4.30e-01
GO:BP	GO:0015850	organic hydroxy compound transport	1	181	4.30e-01
GO:BP	GO:1901617	organic hydroxy compound biosynthetic process	1	174	4.30e-01
GO:BP	GO:0006950	response to stress	1	2763	4.30e-01
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	2	296	4.31e-01
GO:BP	GO:0010646	regulation of cell communication	9	2567	4.33e-01
GO:BP	GO:0055123	digestive system development	1	100	4.33e-01
GO:BP	GO:0048731	system development	1	2886	4.33e-01
GO:BP	GO:0048568	embryonic organ development	2	314	4.33e-01
GO:BP	GO:0008366	axon ensheathment	1	116	4.33e-01
GO:BP	GO:1901990	regulation of mitotic cell cycle phase transition	1	305	4.33e-01
GO:BP	GO:0007272	ensheathment of neurons	1	116	4.33e-01
GO:BP	GO:0030072	peptide hormone secretion	1	169	4.33e-01
GO:BP	GO:0008033	tRNA processing	1	131	4.33e-01
GO:BP	GO:0042552	myelination	1	114	4.33e-01
GO:BP	GO:0042221	response to chemical	1	2456	4.33e-01
GO:BP	GO:0003012	muscle system process	1	334	4.33e-01
GO:BP	GO:0007605	sensory perception of sound	1	97	4.33e-01
GO:BP	GO:0035051	cardiocyte differentiation	1	134	4.34e-01
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	1	3054	4.34e-01
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	1	3059	4.35e-01
GO:BP	GO:0051234	establishment of localization	2	3453	4.35e-01
GO:BP	GO:1903522	regulation of blood circulation	1	197	4.35e-01
GO:BP	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	1	123	4.35e-01
GO:BP	GO:0035108	limb morphogenesis	1	113	4.35e-01
GO:BP	GO:0035107	appendage morphogenesis	1	113	4.35e-01
GO:BP	GO:0002790	peptide secretion	1	173	4.35e-01
GO:BP	GO:0018130	heterocycle biosynthetic process	1	3115	4.38e-01
GO:BP	GO:0072331	signal transduction by p53 class mediator	1	163	4.38e-01
GO:BP	GO:0019438	aromatic compound biosynthetic process	1	3116	4.38e-01
GO:BP	GO:0072073	kidney epithelium development	1	113	4.38e-01
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	1	1203	4.38e-01
GO:BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	1	157	4.39e-01
GO:BP	GO:0046883	regulation of hormone secretion	1	171	4.40e-01
GO:BP	GO:0051179	localization	4	3983	4.40e-01
GO:BP	GO:0035264	multicellular organism growth	1	124	4.42e-01
GO:BP	GO:0007611	learning or memory	1	201	4.42e-01
GO:BP	GO:0071705	nitrogen compound transport	1	1689	4.43e-01
GO:BP	GO:0098662	inorganic cation transmembrane transport	3	537	4.44e-01
GO:BP	GO:0030030	cell projection organization	1	1236	4.44e-01
GO:BP	GO:0010639	negative regulation of organelle organization	1	310	4.44e-01
GO:BP	GO:0050708	regulation of protein secretion	1	186	4.46e-01
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	1	3221	4.46e-01
GO:BP	GO:0008202	steroid metabolic process	1	203	4.49e-01
GO:BP	GO:0015833	peptide transport	1	182	4.50e-01
GO:BP	GO:0001558	regulation of cell growth	1	352	4.50e-01
GO:BP	GO:0060070	canonical Wnt signaling pathway	1	254	4.53e-01
GO:BP	GO:0032102	negative regulation of response to external stimulus	1	291	4.53e-01
GO:BP	GO:0062012	regulation of small molecule metabolic process	1	248	4.53e-01
GO:BP	GO:0051649	establishment of localization in cell	1	1842	4.53e-01
GO:BP	GO:0042770	signal transduction in response to DNA damage	1	180	4.54e-01
GO:BP	GO:0043405	regulation of MAP kinase activity	1	141	4.57e-01
GO:BP	GO:0098655	monoatomic cation transmembrane transport	3	554	4.59e-01
GO:BP	GO:0050954	sensory perception of mechanical stimulus	1	111	4.61e-01
GO:BP	GO:0046578	regulation of Ras protein signal transduction	1	156	4.61e-01
GO:BP	GO:0010975	regulation of neuron projection development	1	374	4.61e-01
GO:BP	GO:0009888	tissue development	6	1425	4.61e-01
GO:BP	GO:0061351	neural precursor cell proliferation	1	122	4.61e-01
GO:BP	GO:0007409	axonogenesis	1	350	4.61e-01
GO:BP	GO:0048592	eye morphogenesis	1	114	4.61e-01
GO:BP	GO:0045786	negative regulation of cell cycle	1	337	4.61e-01
GO:BP	GO:0032880	regulation of protein localization	1	719	4.61e-01
GO:BP	GO:0030324	lung development	1	144	4.61e-01
GO:BP	GO:0061138	morphogenesis of a branching epithelium	1	143	4.61e-01
GO:BP	GO:0030323	respiratory tube development	1	148	4.66e-01
GO:BP	GO:0006109	regulation of carbohydrate metabolic process	1	147	4.66e-01
GO:BP	GO:0030001	metal ion transport	2	568	4.66e-01
GO:BP	GO:0007275	multicellular organism development	1	3355	4.66e-01
GO:BP	GO:0019216	regulation of lipid metabolic process	1	251	4.66e-01
GO:BP	GO:0010648	negative regulation of cell communication	4	1088	4.66e-01
GO:BP	GO:0051235	maintenance of location	1	263	4.66e-01
GO:BP	GO:0030111	regulation of Wnt signaling pathway	1	274	4.66e-01
GO:BP	GO:0023057	negative regulation of signaling	4	1090	4.66e-01
GO:BP	GO:0006935	chemotaxis	1	264	4.66e-01
GO:BP	GO:0140694	non-membrane-bounded organelle assembly	1	364	4.66e-01
GO:BP	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	1	144	4.66e-01
GO:BP	GO:0042330	taxis	1	264	4.66e-01
GO:BP	GO:0006518	peptide metabolic process	1	781	4.66e-01
GO:BP	GO:0031399	regulation of protein modification process	4	1096	4.67e-01
GO:BP	GO:0032879	regulation of localization	4	1570	4.70e-01
GO:BP	GO:0008104	protein localization	2	2128	4.72e-01
GO:BP	GO:0070727	cellular macromolecule localization	2	2137	4.73e-01
GO:BP	GO:0009967	positive regulation of signal transduction	5	1116	4.73e-01
GO:BP	GO:0001501	skeletal system development	2	361	4.76e-01
GO:BP	GO:0048839	inner ear development	1	129	4.76e-01
GO:BP	GO:0001763	morphogenesis of a branching structure	1	155	4.79e-01
GO:BP	GO:0071824	protein-DNA complex organization	2	711	4.79e-01
GO:BP	GO:0048736	appendage development	1	141	4.83e-01
GO:BP	GO:0060173	limb development	1	141	4.83e-01
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	1	3743	4.83e-01
GO:BP	GO:0006066	alcohol metabolic process	1	263	4.83e-01
GO:BP	GO:0046879	hormone secretion	1	212	4.83e-01
GO:BP	GO:0009416	response to light stimulus	1	241	4.84e-01
GO:BP	GO:0009410	response to xenobiotic stimulus	1	275	4.84e-01
GO:BP	GO:0098660	inorganic ion transmembrane transport	2	582	4.84e-01
GO:BP	GO:1901987	regulation of cell cycle phase transition	1	387	4.85e-01
GO:BP	GO:0016049	cell growth	1	416	4.85e-01
GO:BP	GO:0060341	regulation of cellular localization	1	805	4.85e-01
GO:BP	GO:0070374	positive regulation of ERK1 and ERK2 cascade	1	120	4.85e-01
GO:BP	GO:0060541	respiratory system development	1	161	4.86e-01
GO:BP	GO:0046394	carboxylic acid biosynthetic process	1	223	4.87e-01
GO:BP	GO:0061564	axon development	1	388	4.89e-01
GO:BP	GO:0050679	positive regulation of epithelial cell proliferation	1	152	4.89e-01
GO:BP	GO:0016053	organic acid biosynthetic process	1	224	4.89e-01
GO:BP	GO:0009914	hormone transport	1	217	4.89e-01
GO:BP	GO:0001932	regulation of protein phosphorylation	3	758	4.89e-01
GO:BP	GO:0051640	organelle localization	2	521	4.90e-01
GO:BP	GO:0009755	hormone-mediated signaling pathway	1	142	4.90e-01
GO:BP	GO:0009894	regulation of catabolic process	1	883	4.90e-01
GO:BP	GO:0070647	protein modification by small protein conjugation or removal	3	870	4.90e-01
GO:BP	GO:0044772	mitotic cell cycle phase transition	1	411	4.91e-01
GO:BP	GO:0045859	regulation of protein kinase activity	2	473	4.91e-01
GO:BP	GO:0032501	multicellular organismal process	9	4807	4.91e-01
GO:BP	GO:0040007	growth	3	737	4.94e-01
GO:BP	GO:0043086	negative regulation of catalytic activity	2	456	4.95e-01
GO:BP	GO:0015980	energy derivation by oxidation of organic compounds	1	288	4.96e-01
GO:BP	GO:0010810	regulation of cell-substrate adhesion	1	171	4.96e-01
GO:BP	GO:0016477	cell migration	2	1065	4.96e-01
GO:BP	GO:0030163	protein catabolic process	1	906	4.97e-01
GO:BP	GO:1901135	carbohydrate derivative metabolic process	1	841	5.00e-01
GO:BP	GO:0019752	carboxylic acid metabolic process	2	684	5.02e-01
GO:BP	GO:0043269	regulation of monoatomic ion transport	2	369	5.02e-01
GO:BP	GO:0043583	ear development	1	150	5.06e-01
GO:BP	GO:0051216	cartilage development	1	149	5.06e-01
GO:BP	GO:0006996	organelle organization	2	2974	5.09e-01
GO:BP	GO:0042886	amide transport	1	237	5.12e-01
GO:BP	GO:0006399	tRNA metabolic process	1	189	5.12e-01
GO:BP	GO:0048856	anatomical structure development	2	4100	5.12e-01
GO:BP	GO:0010632	regulation of epithelial cell migration	1	195	5.12e-01
GO:BP	GO:0043436	oxoacid metabolic process	2	699	5.12e-01
GO:BP	GO:0002064	epithelial cell development	1	156	5.12e-01
GO:BP	GO:0071356	cellular response to tumor necrosis factor	1	159	5.13e-01
GO:BP	GO:0048514	blood vessel morphogenesis	2	461	5.13e-01
GO:BP	GO:0006082	organic acid metabolic process	2	703	5.14e-01
GO:BP	GO:0010468	regulation of gene expression	1	3587	5.15e-01
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	1	451	5.15e-01
GO:BP	GO:0034330	cell junction organization	1	586	5.15e-01
GO:BP	GO:0009306	protein secretion	1	262	5.15e-01
GO:BP	GO:0051098	regulation of binding	1	314	5.15e-01
GO:BP	GO:0006869	lipid transport	1	271	5.15e-01
GO:BP	GO:0007346	regulation of mitotic cell cycle	1	438	5.15e-01
GO:BP	GO:0035592	establishment of protein localization to extracellular region	1	262	5.15e-01
GO:BP	GO:0048523	negative regulation of cellular process	1	3773	5.15e-01
GO:BP	GO:0031344	regulation of cell projection organization	2	542	5.20e-01
GO:BP	GO:0007507	heart development	2	512	5.20e-01
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	1	4243	5.20e-01
GO:BP	GO:0071692	protein localization to extracellular region	1	266	5.20e-01
GO:BP	GO:0034220	monoatomic ion transmembrane transport	2	650	5.21e-01
GO:BP	GO:2000241	regulation of reproductive process	1	126	5.21e-01
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	1	3702	5.22e-01
GO:BP	GO:0033036	macromolecule localization	1	2448	5.24e-01
GO:BP	GO:0048738	cardiac muscle tissue development	1	202	5.25e-01
GO:BP	GO:0022402	cell cycle process	4	1078	5.25e-01
GO:BP	GO:0048522	positive regulation of cellular process	1	4197	5.27e-01
GO:BP	GO:0033365	protein localization to organelle	1	860	5.27e-01
GO:BP	GO:0006812	monoatomic cation transport	2	677	5.27e-01
GO:BP	GO:0031326	regulation of cellular biosynthetic process	1	3794	5.30e-01
GO:BP	GO:0080090	regulation of primary metabolic process	1	4371	5.30e-01
GO:BP	GO:0009889	regulation of biosynthetic process	1	3820	5.32e-01
GO:BP	GO:0043603	amide metabolic process	1	1003	5.33e-01
GO:BP	GO:0034612	response to tumor necrosis factor	1	176	5.33e-01
GO:BP	GO:0040008	regulation of growth	1	493	5.33e-01
GO:BP	GO:0048598	embryonic morphogenesis	2	438	5.33e-01
GO:BP	GO:0006631	fatty acid metabolic process	1	276	5.34e-01
GO:BP	GO:0042325	regulation of phosphorylation	3	841	5.34e-01
GO:BP	GO:0048519	negative regulation of biological process	1	4026	5.39e-01
GO:BP	GO:0016055	Wnt signaling pathway	1	379	5.42e-01
GO:BP	GO:0036211	protein modification process	1	2751	5.42e-01
GO:BP	GO:0010876	lipid localization	1	309	5.42e-01
GO:BP	GO:0048812	neuron projection morphogenesis	1	500	5.42e-01
GO:BP	GO:0044770	cell cycle phase transition	1	496	5.42e-01
GO:BP	GO:0198738	cell-cell signaling by wnt	1	380	5.42e-01
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	1	529	5.42e-01
GO:BP	GO:0003007	heart morphogenesis	1	217	5.42e-01
GO:BP	GO:0043549	regulation of kinase activity	2	548	5.47e-01
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	1	515	5.47e-01
GO:BP	GO:1903039	positive regulation of leukocyte cell-cell adhesion	1	157	5.49e-01
GO:BP	GO:0006417	regulation of translation	1	373	5.49e-01
GO:BP	GO:0048858	cell projection morphogenesis	1	519	5.49e-01
GO:BP	GO:0042592	homeostatic process	5	1189	5.51e-01
GO:BP	GO:0071495	cellular response to endogenous stimulus	4	1097	5.53e-01
GO:BP	GO:0009887	animal organ morphogenesis	3	725	5.53e-01
GO:BP	GO:0009314	response to radiation	1	339	5.53e-01
GO:BP	GO:0051049	regulation of transport	3	1268	5.53e-01
GO:BP	GO:0009966	regulation of signal transduction	7	2271	5.53e-01
GO:BP	GO:0045765	regulation of angiogenesis	1	200	5.53e-01
GO:BP	GO:0032502	developmental process	2	4445	5.55e-01
GO:BP	GO:0051276	chromosome organization	2	533	5.55e-01
GO:BP	GO:0032990	cell part morphogenesis	1	539	5.55e-01
GO:BP	GO:1901342	regulation of vasculature development	1	202	5.55e-01
GO:BP	GO:0048518	positive regulation of biological process	1	4566	5.55e-01
GO:BP	GO:0010647	positive regulation of cell communication	5	1249	5.57e-01
GO:BP	GO:0023056	positive regulation of signaling	5	1252	5.57e-01
GO:BP	GO:0043412	macromolecule modification	1	2948	5.57e-01
GO:BP	GO:0045165	cell fate commitment	1	157	5.57e-01
GO:BP	GO:0051641	cellular localization	1	2822	5.59e-01
GO:BP	GO:0051345	positive regulation of hydrolase activity	1	412	5.60e-01
GO:BP	GO:0001568	blood vessel development	2	537	5.60e-01
GO:BP	GO:0006915	apoptotic process	5	1452	5.68e-01
GO:BP	GO:0098609	cell-cell adhesion	1	599	5.68e-01
GO:BP	GO:0035295	tube development	3	822	5.68e-01
GO:BP	GO:1901565	organonitrogen compound catabolic process	1	1151	5.68e-01
GO:BP	GO:0009057	macromolecule catabolic process	1	1215	5.75e-01
GO:BP	GO:0018105	peptidyl-serine phosphorylation	1	242	5.78e-01
GO:BP	GO:0021537	telencephalon development	1	208	5.78e-01
GO:BP	GO:0048878	chemical homeostasis	3	689	5.78e-01
GO:BP	GO:1903047	mitotic cell cycle process	2	689	5.78e-01
GO:BP	GO:0044281	small molecule metabolic process	3	1386	5.78e-01
GO:BP	GO:0001944	vasculature development	2	562	5.79e-01
GO:BP	GO:0051346	negative regulation of hydrolase activity	1	206	5.79e-01
GO:BP	GO:0061448	connective tissue development	1	212	5.83e-01
GO:BP	GO:0010631	epithelial cell migration	1	253	5.83e-01
GO:BP	GO:0034248	regulation of amide metabolic process	1	426	5.83e-01
GO:BP	GO:0051146	striated muscle cell differentiation	1	239	5.83e-01
GO:BP	GO:0031323	regulation of cellular metabolic process	1	4563	5.83e-01
GO:BP	GO:0090132	epithelium migration	1	253	5.84e-01
GO:BP	GO:0072359	circulatory system development	3	888	5.85e-01
GO:BP	GO:0060255	regulation of macromolecule metabolic process	1	4593	5.85e-01
GO:BP	GO:0023061	signal release	1	329	5.85e-01
GO:BP	GO:0006811	monoatomic ion transport	1	788	5.88e-01
GO:BP	GO:0090130	tissue migration	1	257	5.89e-01
GO:BP	GO:0050877	nervous system process	1	628	5.89e-01
GO:BP	GO:0022409	positive regulation of cell-cell adhesion	1	188	5.89e-01
GO:BP	GO:0018209	peptidyl-serine modification	1	254	5.90e-01
GO:BP	GO:0009059	macromolecule biosynthetic process	2	5148	5.92e-01
GO:BP	GO:0012501	programmed cell death	5	1498	5.93e-01
GO:BP	GO:0032989	cellular component morphogenesis	1	627	5.93e-01
GO:BP	GO:0016070	RNA metabolic process	1	3573	5.93e-01
GO:BP	GO:0030198	extracellular matrix organization	1	233	5.94e-01
GO:BP	GO:0019220	regulation of phosphate metabolic process	3	949	5.94e-01
GO:BP	GO:0008219	cell death	5	1504	5.94e-01
GO:BP	GO:0043062	extracellular structure organization	1	234	5.94e-01
GO:BP	GO:0051174	regulation of phosphorus metabolic process	3	950	5.94e-01
GO:BP	GO:0045229	external encapsulating structure organization	1	234	5.94e-01
GO:BP	GO:0060562	epithelial tube morphogenesis	1	276	5.97e-01
GO:BP	GO:0007265	Ras protein signal transduction	1	287	5.97e-01
GO:BP	GO:0051223	regulation of protein transport	1	404	5.98e-01
GO:BP	GO:0006091	generation of precursor metabolites and energy	1	423	5.98e-01
GO:BP	GO:0043687	post-translational protein modification	3	1102	5.99e-01
GO:BP	GO:0065009	regulation of molecular function	6	1905	6.07e-01
GO:BP	GO:0007420	brain development	2	546	6.08e-01
GO:BP	GO:0071900	regulation of protein serine/threonine kinase activity	1	274	6.10e-01
GO:BP	GO:0010564	regulation of cell cycle process	1	622	6.12e-01
GO:BP	GO:0070201	regulation of establishment of protein localization	1	428	6.13e-01
GO:BP	GO:0019222	regulation of metabolic process	1	4998	6.14e-01
GO:BP	GO:0051338	regulation of transferase activity	2	664	6.15e-01
GO:BP	GO:0010817	regulation of hormone levels	1	337	6.17e-01
GO:BP	GO:0031589	cell-substrate adhesion	1	271	6.18e-01
GO:BP	GO:0044057	regulation of system process	1	398	6.20e-01
GO:BP	GO:0051716	cellular response to stimulus	1	4929	6.20e-01
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	1	680	6.21e-01
GO:BP	GO:0090304	nucleic acid metabolic process	1	4018	6.25e-01
GO:BP	GO:0071345	cellular response to cytokine stimulus	2	544	6.25e-01
GO:BP	GO:0080134	regulation of response to stress	3	1074	6.25e-01
GO:BP	GO:1903530	regulation of secretion by cell	1	382	6.26e-01
GO:BP	GO:0006874	intracellular calcium ion homeostasis	1	208	6.27e-01
GO:BP	GO:0030522	intracellular receptor signaling pathway	1	256	6.29e-01
GO:BP	GO:1903037	regulation of leukocyte cell-cell adhesion	1	210	6.29e-01
GO:BP	GO:0050678	regulation of epithelial cell proliferation	1	268	6.30e-01
GO:BP	GO:0065003	protein-containing complex assembly	1	1320	6.32e-01
GO:BP	GO:0060322	head development	2	588	6.35e-01
GO:BP	GO:0060429	epithelium development	3	849	6.35e-01
GO:BP	GO:0044283	small molecule biosynthetic process	1	432	6.35e-01
GO:BP	GO:0035239	tube morphogenesis	2	663	6.49e-01
GO:BP	GO:0009719	response to endogenous stimulus	4	1260	6.49e-01
GO:BP	GO:0055074	calcium ion homeostasis	1	221	6.51e-01
GO:BP	GO:0000902	cell morphogenesis	1	740	6.53e-01
GO:BP	GO:0000278	mitotic cell cycle	2	815	6.55e-01
GO:BP	GO:0051046	regulation of secretion	1	413	6.55e-01
GO:BP	GO:0007610	behavior	1	439	6.55e-01
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	1	4423	6.55e-01
GO:BP	GO:0032787	monocarboxylic acid metabolic process	1	434	6.59e-01
GO:BP	GO:0007159	leukocyte cell-cell adhesion	1	233	6.61e-01
GO:BP	GO:0051246	regulation of protein metabolic process	5	1895	6.62e-01
GO:BP	GO:0031175	neuron projection development	1	774	6.63e-01
GO:BP	GO:0006629	lipid metabolic process	2	989	6.65e-01
GO:BP	GO:0046483	heterocycle metabolic process	1	4537	6.66e-01
GO:BP	GO:0044249	cellular biosynthetic process	2	5813	6.67e-01
GO:BP	GO:0006725	cellular aromatic compound metabolic process	1	4561	6.69e-01
GO:BP	GO:0042692	muscle cell differentiation	1	329	6.69e-01
GO:BP	GO:0048513	animal organ development	7	2156	6.70e-01
GO:BP	GO:0051336	regulation of hydrolase activity	2	680	6.71e-01
GO:BP	GO:0006338	chromatin remodeling	1	520	6.71e-01
GO:BP	GO:0034097	response to cytokine	2	609	6.71e-01
GO:BP	GO:0007600	sensory perception	2	259	6.71e-01
GO:BP	GO:1901576	organic substance biosynthetic process	2	5875	6.73e-01
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	2	741	6.78e-01
GO:BP	GO:0009058	biosynthetic process	2	5912	6.78e-01
GO:BP	GO:1901360	organic cyclic compound metabolic process	1	4713	6.82e-01
GO:BP	GO:0032101	regulation of response to external stimulus	1	690	6.83e-01
GO:BP	GO:0048583	regulation of response to stimulus	8	2877	6.84e-01
GO:BP	GO:0050673	epithelial cell proliferation	1	318	6.86e-01
GO:BP	GO:0030900	forebrain development	1	290	6.88e-01
GO:BP	GO:0006468	protein phosphorylation	3	1130	6.89e-01
GO:BP	GO:0019538	protein metabolic process	1	4202	6.91e-01
GO:BP	GO:0034641	cellular nitrogen compound metabolic process	1	4913	6.91e-01
GO:BP	GO:0023052	signaling	10	4134	6.97e-01
GO:BP	GO:1901575	organic substance catabolic process	1	1731	7.05e-01
GO:BP	GO:0043933	protein-containing complex organization	1	1964	7.07e-01
GO:BP	GO:0007155	cell adhesion	1	996	7.07e-01
GO:BP	GO:0048666	neuron development	1	873	7.07e-01
GO:BP	GO:0022407	regulation of cell-cell adhesion	1	292	7.08e-01
GO:BP	GO:0045785	positive regulation of cell adhesion	1	319	7.08e-01
GO:BP	GO:0050896	response to stimulus	1	5721	7.12e-01
GO:BP	GO:0006412	translation	1	657	7.18e-01
GO:BP	GO:0007154	cell communication	10	4210	7.19e-01
GO:BP	GO:0034470	ncRNA processing	1	397	7.21e-01
GO:BP	GO:0007417	central nervous system development	1	750	7.22e-01
GO:BP	GO:0006259	DNA metabolic process	1	886	7.23e-01
GO:BP	GO:0010467	gene expression	1	4733	7.26e-01
GO:BP	GO:0006325	chromatin organization	1	631	7.29e-01
GO:BP	GO:0043043	peptide biosynthetic process	1	677	7.29e-01
GO:BP	GO:0002009	morphogenesis of an epithelium	1	415	7.30e-01
GO:BP	GO:0001525	angiogenesis	1	389	7.33e-01
GO:BP	GO:0032940	secretion by cell	1	573	7.43e-01
GO:BP	GO:0048584	positive regulation of response to stimulus	5	1557	7.43e-01
GO:BP	GO:0033993	response to lipid	1	594	7.60e-01
GO:BP	GO:0033043	regulation of organelle organization	1	1001	7.60e-01
GO:BP	GO:0014070	response to organic cyclic compound	1	634	7.60e-01
GO:BP	GO:0022607	cellular component assembly	1	2459	7.61e-01
GO:BP	GO:0043085	positive regulation of catalytic activity	1	815	7.61e-01
GO:BP	GO:1901564	organonitrogen compound metabolic process	1	4919	7.62e-01
GO:BP	GO:0140352	export from cell	1	617	7.67e-01
GO:BP	GO:0009056	catabolic process	1	2108	7.67e-01
GO:BP	GO:0016310	phosphorylation	3	1338	7.79e-01
GO:BP	GO:0043604	amide biosynthetic process	1	785	7.82e-01
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	1	470	7.82e-01
GO:BP	GO:0044085	cellular component biogenesis	1	2722	7.83e-01
GO:BP	GO:0051128	regulation of cellular component organization	2	1981	7.83e-01
GO:BP	GO:0030003	intracellular monoatomic cation homeostasis	1	364	7.84e-01
GO:BP	GO:0098771	inorganic ion homeostasis	1	355	7.88e-01
GO:BP	GO:0046903	secretion	1	647	7.88e-01
GO:BP	GO:0006873	intracellular monoatomic ion homeostasis	1	369	7.88e-01
GO:BP	GO:0048729	tissue morphogenesis	1	501	7.88e-01
GO:BP	GO:0009790	embryo development	2	859	7.91e-01
GO:BP	GO:0050790	regulation of catalytic activity	3	1349	7.92e-01
GO:BP	GO:0044255	cellular lipid metabolic process	1	736	8.03e-01
GO:BP	GO:0032870	cellular response to hormone stimulus	1	449	8.03e-01
GO:BP	GO:0001934	positive regulation of protein phosphorylation	1	465	8.03e-01
GO:BP	GO:0055080	monoatomic cation homeostasis	1	410	8.26e-01
GO:BP	GO:0006807	nitrogen compound metabolic process	2	7431	8.29e-01
GO:BP	GO:0010608	post-transcriptional regulation of gene expression	1	475	8.29e-01
GO:BP	GO:0050801	monoatomic ion homeostasis	1	416	8.29e-01
GO:BP	GO:0034660	ncRNA metabolic process	1	561	8.30e-01
GO:BP	GO:0042327	positive regulation of phosphorylation	1	511	8.31e-01
GO:BP	GO:0009628	response to abiotic stimulus	1	848	8.33e-01
GO:BP	GO:0065008	regulation of biological quality	3	2085	8.40e-01
GO:BP	GO:0043170	macromolecule metabolic process	2	7084	8.54e-01
GO:BP	GO:0007186	G protein-coupled receptor signaling pathway	1	386	8.54e-01
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	1	559	8.56e-01
GO:BP	GO:0030155	regulation of cell adhesion	1	535	8.56e-01
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	1	559	8.56e-01
GO:BP	GO:0044093	positive regulation of molecular function	1	1132	8.56e-01
GO:BP	GO:0006974	DNA damage response	1	795	8.67e-01
GO:BP	GO:0055082	intracellular chemical homeostasis	1	498	8.74e-01
GO:BP	GO:0043066	negative regulation of apoptotic process	1	662	8.84e-01
GO:BP	GO:0031401	positive regulation of protein modification process	1	664	8.86e-01
GO:BP	GO:0050794	regulation of cellular process	1	7632	8.90e-01
GO:BP	GO:0043069	negative regulation of programmed cell death	1	685	8.90e-01
GO:BP	GO:0044238	primary metabolic process	2	7788	8.93e-01
GO:BP	GO:0071310	cellular response to organic substance	3	1390	8.93e-01
GO:BP	GO:0007166	cell surface receptor signaling pathway	4	1889	8.95e-01
GO:BP	GO:0009725	response to hormone	1	624	8.98e-01
GO:BP	GO:0019725	cellular homeostasis	1	583	9.06e-01
GO:BP	GO:0044087	regulation of cellular component biogenesis	1	802	9.10e-01
GO:BP	GO:0007165	signal transduction	11	3803	9.12e-01
GO:BP	GO:0009653	anatomical structure morphogenesis	4	1952	9.20e-01
GO:BP	GO:0044237	cellular metabolic process	2	7562	9.21e-01
GO:BP	GO:0050789	regulation of biological process	1	8017	9.25e-01
GO:BP	GO:0016043	cellular component organization	2	5106	9.27e-01
GO:BP	GO:0009605	response to external stimulus	2	1635	9.30e-01
GO:BP	GO:0010033	response to organic substance	4	1942	9.31e-01
GO:BP	GO:1901700	response to oxygen-containing compound	1	1219	9.34e-01
GO:BP	GO:0071840	cellular component organization or biogenesis	2	5307	9.35e-01
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	1	868	9.40e-01
GO:BP	GO:0010628	positive regulation of gene expression	1	795	9.41e-01
GO:BP	GO:0065007	biological regulation	1	8282	9.50e-01
GO:BP	GO:0006796	phosphate-containing compound metabolic process	3	2096	9.56e-01
GO:BP	GO:0006793	phosphorus metabolic process	3	2118	9.58e-01
GO:BP	GO:0000398	mRNA splicing, via spliceosome	1	288	9.63e-01
GO:BP	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1	288	9.63e-01
GO:BP	GO:0000375	RNA splicing, via transesterification reactions	1	292	9.63e-01
GO:BP	GO:0051247	positive regulation of protein metabolic process	1	1067	9.63e-01
GO:BP	GO:0008380	RNA splicing	2	426	9.64e-01
GO:BP	GO:0006397	mRNA processing	2	451	9.67e-01
GO:BP	GO:0016071	mRNA metabolic process	2	671	9.84e-01
GO:BP	GO:0009987	cellular process	1	11410	1.00e+00
GO:BP	GO:0006396	RNA processing	1	928	1.00e+00
GO:BP	GO:0008150	biological_process	1	12027	1.00e+00
GO:BP	GO:0008152	metabolic process	1	8522	1.00e+00
GO:BP	GO:0071704	organic substance metabolic process	1	8176	1.00e+00
KEGG	KEGG:05202	Transcriptional misregulation in cancer	4	128	8.80e-03
KEGG	KEGG:05223	Non-small cell lung cancer	3	67	1.20e-02
KEGG	KEGG:05222	Small cell lung cancer	3	87	1.53e-02
KEGG	KEGG:05216	Thyroid cancer	2	35	1.53e-02
KEGG	KEGG:05226	Gastric cancer	3	117	2.09e-02
KEGG	KEGG:05212	Pancreatic cancer	2	75	2.09e-02
KEGG	KEGG:05213	Endometrial cancer	2	57	2.09e-02
KEGG	KEGG:05214	Glioma	2	67	2.09e-02
KEGG	KEGG:05215	Prostate cancer	1	86	2.09e-02
KEGG	KEGG:05217	Basal cell carcinoma	2	49	2.09e-02
KEGG	KEGG:04115	p53 signaling pathway	2	65	2.09e-02
KEGG	KEGG:05218	Melanoma	2	58	2.09e-02
KEGG	KEGG:05220	Chronic myeloid leukemia	2	75	2.09e-02
KEGG	KEGG:05210	Colorectal cancer	2	84	2.29e-02
KEGG	KEGG:04064	NF-kappa B signaling pathway	2	71	2.96e-02
KEGG	KEGG:04068	FoxO signaling pathway	2	109	4.44e-02
KEGG	KEGG:04210	Apoptosis	2	118	4.44e-02
KEGG	KEGG:00510	N-Glycan biosynthesis	1	48	4.62e-02
KEGG	KEGG:05224	Breast cancer	2	117	4.66e-02
KEGG	KEGG:04110	Cell cycle	2	151	4.77e-02
KEGG	KEGG:04218	Cellular senescence	2	145	4.77e-02
KEGG	KEGG:05225	Hepatocellular carcinoma	2	145	5.04e-02
KEGG	KEGG:05169	Epstein-Barr virus infection	2	153	6.66e-02
KEGG	KEGG:04710	Circadian rhythm	1	30	7.37e-02
KEGG	KEGG:05016	Huntington disease	1	256	1.00e-01
KEGG	KEGG:05014	Amyotrophic lateral sclerosis	1	303	1.14e-01
KEGG	KEGG:04010	MAPK signaling pathway	2	240	1.14e-01
KEGG	KEGG:05221	Acute myeloid leukemia	1	56	1.22e-01
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	1	385	1.32e-01
KEGG	KEGG:04713	Circadian entrainment	1	69	1.56e-01
KEGG	KEGG:05200	Pathways in cancer	3	409	1.56e-01
KEGG	KEGG:04360	Axon guidance	1	162	1.77e-01
KEGG	KEGG:04114	Oocyte meiosis	1	108	3.11e-01
KEGG	KEGG:04080	Neuroactive ligand-receptor interaction	1	108	4.34e-01
KEGG	KEGG:05206	MicroRNAs in cancer	1	149	5.30e-01
KEGG	KEGG:01100	Metabolic pathways	1	1146	5.41e-01
KEGG	KEGG:05168	Herpes simplex virus 1 infection	1	415	6.12e-01
KEGG	KEGG:00000	KEGG root term	1	5548	6.12e-01

TRZnomtable %>%
  filter(source=="KEGG") %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "Enrichment of KEGG terms using nominal pvalue TRZ genes in my data") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

Enrichment of KEGG terms using nominal pvalue TRZ genes in my data
source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:05202	Transcriptional misregulation in cancer	4	128	8.80e-03
KEGG	KEGG:05223	Non-small cell lung cancer	3	67	1.20e-02
KEGG	KEGG:05222	Small cell lung cancer	3	87	1.53e-02
KEGG	KEGG:05216	Thyroid cancer	2	35	1.53e-02
KEGG	KEGG:05226	Gastric cancer	3	117	2.09e-02
KEGG	KEGG:05212	Pancreatic cancer	2	75	2.09e-02
KEGG	KEGG:05213	Endometrial cancer	2	57	2.09e-02
KEGG	KEGG:05214	Glioma	2	67	2.09e-02
KEGG	KEGG:05215	Prostate cancer	1	86	2.09e-02
KEGG	KEGG:05217	Basal cell carcinoma	2	49	2.09e-02
KEGG	KEGG:04115	p53 signaling pathway	2	65	2.09e-02
KEGG	KEGG:05218	Melanoma	2	58	2.09e-02
KEGG	KEGG:05220	Chronic myeloid leukemia	2	75	2.09e-02
KEGG	KEGG:05210	Colorectal cancer	2	84	2.29e-02
KEGG	KEGG:04064	NF-kappa B signaling pathway	2	71	2.96e-02
KEGG	KEGG:04068	FoxO signaling pathway	2	109	4.44e-02
KEGG	KEGG:04210	Apoptosis	2	118	4.44e-02
KEGG	KEGG:00510	N-Glycan biosynthesis	1	48	4.62e-02
KEGG	KEGG:05224	Breast cancer	2	117	4.66e-02
KEGG	KEGG:04110	Cell cycle	2	151	4.77e-02
KEGG	KEGG:04218	Cellular senescence	2	145	4.77e-02
KEGG	KEGG:05225	Hepatocellular carcinoma	2	145	5.04e-02
KEGG	KEGG:05169	Epstein-Barr virus infection	2	153	6.66e-02
KEGG	KEGG:04710	Circadian rhythm	1	30	7.37e-02
KEGG	KEGG:05016	Huntington disease	1	256	1.00e-01
KEGG	KEGG:05014	Amyotrophic lateral sclerosis	1	303	1.14e-01
KEGG	KEGG:04010	MAPK signaling pathway	2	240	1.14e-01
KEGG	KEGG:05221	Acute myeloid leukemia	1	56	1.22e-01
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	1	385	1.32e-01
KEGG	KEGG:04713	Circadian entrainment	1	69	1.56e-01
KEGG	KEGG:05200	Pathways in cancer	3	409	1.56e-01
KEGG	KEGG:04360	Axon guidance	1	162	1.77e-01
KEGG	KEGG:04114	Oocyte meiosis	1	108	3.11e-01
KEGG	KEGG:04080	Neuroactive ligand-receptor interaction	1	108	4.34e-01
KEGG	KEGG:05206	MicroRNAs in cancer	1	149	5.30e-01
KEGG	KEGG:01100	Metabolic pathways	1	1146	5.41e-01
KEGG	KEGG:05168	Herpes simplex virus 1 infection	1	415	6.12e-01
KEGG	KEGG:00000	KEGG root term	1	5548	6.12e-01

TRZ 3 hour nom de

# TRZresgenes3h <- gost(query = TRZ_list3h$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = TRUE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = backGL$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(TRZresgenes3h,"data/DEG-GO/TRZresgenes3h.RDS")
TRZresgenes3h <- readRDS("data/DEG-GO/TRZresgenes3h.RDS")

TRZnom3h <- gostplot(TRZresgenes3h, capped = FALSE, interactive = TRUE)
TRZnom3h

TRZnomtable3h <- TRZresgenes3h$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

TRZnomtable3h %>%
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:1900745	positive regulation of p38MAPK cascade	2	22	6.71e-03
GO:BP	GO:1902746	regulation of lens fiber cell differentiation	2	8	6.71e-03
GO:BP	GO:1902747	negative regulation of lens fiber cell differentiation	2	5	6.71e-03
GO:BP	GO:0120162	positive regulation of cold-induced thermogenesis	2	72	8.98e-03
GO:BP	GO:1900744	regulation of p38MAPK cascade	2	32	8.98e-03
GO:BP	GO:0038066	p38MAPK cascade	2	42	1.06e-02
GO:BP	GO:0010801	negative regulation of peptidyl-threonine phosphorylation	2	15	1.06e-02
GO:BP	GO:0120161	regulation of cold-induced thermogenesis	2	115	1.12e-02
GO:BP	GO:0106106	cold-induced thermogenesis	2	116	1.12e-02
GO:BP	GO:1990845	adaptive thermogenesis	2	127	1.25e-02
GO:BP	GO:0001659	temperature homeostasis	2	135	1.35e-02
GO:BP	GO:0097167	circadian regulation of translation	1	4	1.51e-02
GO:BP	GO:0010719	negative regulation of epithelial to mesenchymal transition	2	29	1.51e-02
GO:BP	GO:0031400	negative regulation of protein modification process	4	396	1.51e-02
GO:BP	GO:0019249	lactate biosynthetic process	1	3	1.51e-02
GO:BP	GO:0001837	epithelial to mesenchymal transition	3	139	1.51e-02
GO:BP	GO:0046330	positive regulation of JNK cascade	2	71	1.51e-02
GO:BP	GO:0051941	regulation of amino acid uptake involved in synaptic transmission	1	3	1.51e-02
GO:BP	GO:0051946	regulation of glutamate uptake involved in transmission of nerve impulse	1	3	1.51e-02
GO:BP	GO:0070345	negative regulation of fat cell proliferation	1	4	1.51e-02
GO:BP	GO:0070306	lens fiber cell differentiation	2	30	1.61e-02
GO:BP	GO:0051935	glutamate reuptake	1	4	1.65e-02
GO:BP	GO:0070304	positive regulation of stress-activated protein kinase signaling cascade	2	97	1.74e-02
GO:BP	GO:0032874	positive regulation of stress-activated MAPK cascade	2	95	1.74e-02
GO:BP	GO:0010799	regulation of peptidyl-threonine phosphorylation	2	35	1.74e-02
GO:BP	GO:0002036	regulation of L-glutamate import across plasma membrane	1	6	1.86e-02
GO:BP	GO:0046328	regulation of JNK cascade	2	113	1.90e-02
GO:BP	GO:0030857	negative regulation of epithelial cell differentiation	2	31	2.01e-02
GO:BP	GO:0051933	amino acid neurotransmitter reuptake	1	5	2.01e-02
GO:BP	GO:0070344	regulation of fat cell proliferation	1	8	2.01e-02
GO:BP	GO:0042754	negative regulation of circadian rhythm	1	8	2.27e-02
GO:BP	GO:0045210	FasL biosynthetic process	1	1	2.27e-02
GO:BP	GO:0043065	positive regulation of apoptotic process	3	394	2.35e-02
GO:BP	GO:0007254	JNK cascade	2	137	2.35e-02
GO:BP	GO:1903789	regulation of amino acid transmembrane transport	1	14	2.39e-02
GO:BP	GO:0048762	mesenchymal cell differentiation	3	205	2.39e-02
GO:BP	GO:0070341	fat cell proliferation	1	11	2.39e-02
GO:BP	GO:0010958	regulation of amino acid import across plasma membrane	1	14	2.39e-02
GO:BP	GO:0070302	regulation of stress-activated protein kinase signaling cascade	2	157	2.39e-02
GO:BP	GO:0043068	positive regulation of programmed cell death	3	403	2.39e-02
GO:BP	GO:0032872	regulation of stress-activated MAPK cascade	2	153	2.39e-02
GO:BP	GO:0098712	L-glutamate import across plasma membrane	1	11	2.44e-02
GO:BP	GO:0050872	white fat cell differentiation	1	15	2.44e-02
GO:BP	GO:0070373	negative regulation of ERK1 and ERK2 cascade	2	58	2.44e-02
GO:BP	GO:0000271	polysaccharide biosynthetic process	2	54	2.44e-02
GO:BP	GO:0051580	regulation of neurotransmitter uptake	1	15	2.44e-02
GO:BP	GO:2000678	negative regulation of transcription regulatory region DNA binding	1	17	2.44e-02
GO:BP	GO:0043408	regulation of MAPK cascade	4	473	2.47e-02
GO:BP	GO:0006089	lactate metabolic process	1	16	2.47e-02
GO:BP	GO:0001933	negative regulation of protein phosphorylation	3	265	2.73e-02
GO:BP	GO:0043153	entrainment of circadian clock by photoperiod	1	23	2.79e-02
GO:BP	GO:0051403	stress-activated MAPK cascade	2	188	2.79e-02
GO:BP	GO:0031098	stress-activated protein kinase signaling cascade	2	194	2.89e-02
GO:BP	GO:0031397	negative regulation of protein ubiquitination	2	76	2.97e-02
GO:BP	GO:0009648	photoperiodism	1	24	2.97e-02
GO:BP	GO:0015813	L-glutamate transmembrane transport	1	18	2.99e-02
GO:BP	GO:0009649	entrainment of circadian clock	1	27	2.99e-02
GO:BP	GO:0051726	regulation of cell cycle	3	941	2.99e-02
GO:BP	GO:0042326	negative regulation of phosphorylation	3	290	2.99e-02
GO:BP	GO:0060485	mesenchyme development	3	250	3.09e-02
GO:BP	GO:0002088	lens development in camera-type eye	2	57	3.09e-02
GO:BP	GO:1900623	regulation of monocyte aggregation	1	3	3.11e-02
GO:BP	GO:0045226	extracellular polysaccharide biosynthetic process	1	2	3.11e-02
GO:BP	GO:0098810	neurotransmitter reuptake	1	21	3.11e-02
GO:BP	GO:0046379	extracellular polysaccharide metabolic process	1	2	3.11e-02
GO:BP	GO:0051938	L-glutamate import	1	24	3.11e-02
GO:BP	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	2	85	3.11e-02
GO:BP	GO:1900625	positive regulation of monocyte aggregation	1	3	3.11e-02
GO:BP	GO:0000165	MAPK cascade	4	553	3.11e-02
GO:BP	GO:1903321	negative regulation of protein modification by small protein conjugation or removal	2	86	3.11e-02
GO:BP	GO:0010717	regulation of epithelial to mesenchymal transition	2	87	3.20e-02
GO:BP	GO:0010563	negative regulation of phosphorus metabolic process	3	335	3.45e-02
GO:BP	GO:0009250	glucan biosynthetic process	1	40	3.45e-02
GO:BP	GO:0018107	peptidyl-threonine phosphorylation	2	96	3.45e-02
GO:BP	GO:0045936	negative regulation of phosphate metabolic process	3	334	3.45e-02
GO:BP	GO:0001504	neurotransmitter uptake	1	29	3.45e-02
GO:BP	GO:0005978	glycogen biosynthetic process	1	40	3.45e-02
GO:BP	GO:0051955	regulation of amino acid transport	1	28	3.45e-02
GO:BP	GO:0005976	polysaccharide metabolic process	2	81	3.45e-02
GO:BP	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway	1	3	3.45e-02
GO:BP	GO:1901874	negative regulation of post-translational protein modification	2	98	3.45e-02
GO:BP	GO:0048871	multicellular organismal-level homeostasis	2	570	3.48e-02
GO:BP	GO:0043392	negative regulation of DNA binding	1	44	3.48e-02
GO:BP	GO:1900127	positive regulation of hyaluronan biosynthetic process	1	4	3.48e-02
GO:BP	GO:0090500	endocardial cushion to mesenchymal transition	1	4	3.48e-02
GO:BP	GO:0089718	amino acid import across plasma membrane	1	38	3.51e-02
GO:BP	GO:0000379	tRNA-type intron splice site recognition and cleavage	1	3	3.54e-02
GO:BP	GO:2000677	regulation of transcription regulatory region DNA binding	1	43	3.57e-02
GO:BP	GO:0018210	peptidyl-threonine modification	2	103	3.61e-02
GO:BP	GO:0060437	lung growth	1	4	3.69e-02
GO:BP	GO:0002931	response to ischemia	1	48	3.92e-02
GO:BP	GO:0070487	monocyte aggregation	1	4	3.93e-02
GO:BP	GO:0015800	acidic amino acid transport	1	39	4.03e-02
GO:BP	GO:0019229	regulation of vasoconstriction	1	38	4.05e-02
GO:BP	GO:0034089	establishment of meiotic sister chromatid cohesion	1	4	4.06e-02
GO:BP	GO:1901842	negative regulation of high voltage-gated calcium channel activity	1	4	4.08e-02
GO:BP	GO:1902475	L-alpha-amino acid transmembrane transport	1	51	4.30e-02
GO:BP	GO:0032922	circadian regulation of gene expression	1	63	4.32e-02
GO:BP	GO:0017015	regulation of transforming growth factor beta receptor signaling pathway	2	126	4.34e-02
GO:BP	GO:0070295	renal water absorption	1	6	4.34e-02
GO:BP	GO:1903844	regulation of cellular response to transforming growth factor beta stimulus	2	127	4.35e-02
GO:BP	GO:0005977	glycogen metabolic process	1	64	4.35e-02
GO:BP	GO:0060449	bud elongation involved in lung branching	1	7	4.35e-02
GO:BP	GO:0090101	negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	2	122	4.35e-02
GO:BP	GO:1902533	positive regulation of intracellular signal transduction	4	707	4.35e-02
GO:BP	GO:0060349	bone morphogenesis	2	74	4.35e-02
GO:BP	GO:0032890	regulation of organic acid transport	1	48	4.35e-02
GO:BP	GO:0044042	glucan metabolic process	1	65	4.35e-02
GO:BP	GO:0043410	positive regulation of MAPK cascade	3	316	4.41e-02
GO:BP	GO:0051248	negative regulation of protein metabolic process	4	799	4.41e-02
GO:BP	GO:0042310	vasoconstriction	1	51	4.46e-02
GO:BP	GO:1900125	regulation of hyaluronan biosynthetic process	1	6	4.52e-02
GO:BP	GO:0015807	L-amino acid transport	1	62	4.53e-02
GO:BP	GO:0030856	regulation of epithelial cell differentiation	2	100	4.53e-02
GO:BP	GO:0006112	energy reserve metabolic process	1	72	4.53e-02
GO:BP	GO:0006094	gluconeogenesis	1	70	4.53e-02
GO:BP	GO:0019319	hexose biosynthetic process	1	73	4.65e-02
GO:BP	GO:0030010	establishment of cell polarity	2	135	4.72e-02
GO:BP	GO:0006835	dicarboxylic acid transport	1	61	4.72e-02
GO:BP	GO:0051588	regulation of neurotransmitter transport	1	71	4.83e-02
GO:BP	GO:0051952	regulation of amine transport	1	56	4.84e-02
GO:BP	GO:0046364	monosaccharide biosynthetic process	1	82	4.90e-02
GO:BP	GO:0003333	amino acid transmembrane transport	1	70	4.91e-02
GO:BP	GO:0080135	regulation of cellular response to stress	3	585	5.05e-02
GO:BP	GO:0043409	negative regulation of MAPK cascade	2	145	5.14e-02
GO:BP	GO:0003097	renal water transport	1	7	5.14e-02
GO:BP	GO:0015837	amine transport	1	59	5.14e-02
GO:BP	GO:0042752	regulation of circadian rhythm	1	93	5.33e-02
GO:BP	GO:0007049	cell cycle	3	1515	5.42e-02
GO:BP	GO:0051101	regulation of DNA binding	1	102	5.53e-02
GO:BP	GO:0001654	eye development	3	273	5.66e-02
GO:BP	GO:0150063	visual system development	3	274	5.77e-02
GO:BP	GO:0048880	sensory system development	3	276	5.88e-02
GO:BP	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway	1	11	5.88e-02
GO:BP	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway	1	8	5.88e-02
GO:BP	GO:0044092	negative regulation of molecular function	4	730	6.19e-02
GO:BP	GO:0035296	regulation of tube diameter	1	98	6.19e-02
GO:BP	GO:0097746	blood vessel diameter maintenance	1	98	6.19e-02
GO:BP	GO:0051549	positive regulation of keratinocyte migration	1	11	6.19e-02
GO:BP	GO:0035150	regulation of tube size	1	98	6.19e-02
GO:BP	GO:0006469	negative regulation of protein kinase activity	2	173	6.21e-02
GO:BP	GO:0006865	amino acid transport	1	103	6.21e-02
GO:BP	GO:1905039	carboxylic acid transmembrane transport	1	111	6.25e-02
GO:BP	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus	1	10	6.25e-02
GO:BP	GO:0030213	hyaluronan biosynthetic process	1	10	6.25e-02
GO:BP	GO:0035810	positive regulation of urine volume	1	10	6.25e-02
GO:BP	GO:0036302	atrioventricular canal development	1	12	6.25e-02
GO:BP	GO:0007179	transforming growth factor beta receptor signaling pathway	2	177	6.25e-02
GO:BP	GO:0070486	leukocyte aggregation	1	9	6.25e-02
GO:BP	GO:1903825	organic acid transmembrane transport	1	112	6.25e-02
GO:BP	GO:0051100	negative regulation of binding	1	133	6.32e-02
GO:BP	GO:0034085	establishment of sister chromatid cohesion	1	10	6.33e-02
GO:BP	GO:0050796	regulation of insulin secretion	1	119	6.54e-02
GO:BP	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	1	16	6.54e-02
GO:BP	GO:0010838	positive regulation of keratinocyte proliferation	1	9	6.54e-02
GO:BP	GO:0031396	regulation of protein ubiquitination	2	194	6.54e-02
GO:BP	GO:1901841	regulation of high voltage-gated calcium channel activity	1	12	6.54e-02
GO:BP	GO:0051547	regulation of keratinocyte migration	1	13	6.54e-02
GO:BP	GO:0033673	negative regulation of kinase activity	2	191	6.67e-02
GO:BP	GO:0035265	organ growth	2	128	6.71e-02
GO:BP	GO:0044849	estrous cycle	1	14	6.72e-02
GO:BP	GO:0001505	regulation of neurotransmitter levels	1	132	6.90e-02
GO:BP	GO:0006006	glucose metabolic process	1	153	6.97e-02
GO:BP	GO:0016051	carbohydrate biosynthetic process	2	160	6.99e-02
GO:BP	GO:1901201	regulation of extracellular matrix assembly	1	15	6.99e-02
GO:BP	GO:0007163	establishment or maintenance of cell polarity	2	197	7.06e-02
GO:BP	GO:0051240	positive regulation of multicellular organismal process	2	1103	7.06e-02
GO:BP	GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway	1	16	7.08e-02
GO:BP	GO:0098739	import across plasma membrane	1	130	7.12e-02
GO:BP	GO:0090276	regulation of peptide hormone secretion	1	135	7.12e-02
GO:BP	GO:0006836	neurotransmitter transport	1	141	7.12e-02
GO:BP	GO:0002791	regulation of peptide secretion	1	137	7.12e-02
GO:BP	GO:0030073	insulin secretion	1	144	7.12e-02
GO:BP	GO:0007623	circadian rhythm	1	160	7.12e-02
GO:BP	GO:0090087	regulation of peptide transport	1	139	7.15e-02
GO:BP	GO:0042592	homeostatic process	2	1189	7.33e-02
GO:BP	GO:0072330	monocarboxylic acid biosynthetic process	1	146	7.34e-02
GO:BP	GO:0060602	branch elongation of an epithelium	1	15	7.41e-02
GO:BP	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation	1	13	7.41e-02
GO:BP	GO:0090092	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	2	211	7.42e-02
GO:BP	GO:0055012	ventricular cardiac muscle cell differentiation	1	15	7.42e-02
GO:BP	GO:0051177	meiotic sister chromatid cohesion	1	11	7.42e-02
GO:BP	GO:0045444	fat cell differentiation	1	187	7.54e-02
GO:BP	GO:0071560	cellular response to transforming growth factor beta stimulus	2	222	7.54e-02
GO:BP	GO:0019318	hexose metabolic process	1	187	7.54e-02
GO:BP	GO:0051546	keratinocyte migration	1	15	7.54e-02
GO:BP	GO:0071498	cellular response to fluid shear stress	1	19	7.54e-02
GO:BP	GO:0042981	regulation of apoptotic process	5	1092	7.54e-02
GO:BP	GO:0051348	negative regulation of transferase activity	2	225	7.54e-02
GO:BP	GO:1901617	organic hydroxy compound biosynthetic process	1	174	7.54e-02
GO:BP	GO:1903320	regulation of protein modification by small protein conjugation or removal	2	232	7.54e-02
GO:BP	GO:0000394	RNA splicing, via endonucleolytic cleavage and ligation	1	14	7.54e-02
GO:BP	GO:0071559	response to transforming growth factor beta	2	227	7.61e-02
GO:BP	GO:1900746	regulation of vascular endothelial growth factor signaling pathway	1	18	7.61e-02
GO:BP	GO:0036120	cellular response to platelet-derived growth factor stimulus	1	20	7.61e-02
GO:BP	GO:0030072	peptide hormone secretion	1	169	7.61e-02
GO:BP	GO:1903522	regulation of blood circulation	1	197	7.61e-02
GO:BP	GO:0002790	peptide secretion	1	173	7.61e-02
GO:BP	GO:0035809	regulation of urine volume	1	14	7.61e-02
GO:BP	GO:1901386	negative regulation of voltage-gated calcium channel activity	1	14	7.61e-02
GO:BP	GO:0046883	regulation of hormone secretion	1	171	7.76e-02
GO:BP	GO:0005996	monosaccharide metabolic process	1	212	7.77e-02
GO:BP	GO:0071363	cellular response to growth factor stimulus	3	549	7.77e-02
GO:BP	GO:0003018	vascular process in circulatory system	1	198	7.77e-02
GO:BP	GO:0050708	regulation of protein secretion	1	186	7.77e-02
GO:BP	GO:0043067	regulation of programmed cell death	5	1124	7.77e-02
GO:BP	GO:0015833	peptide transport	1	182	7.81e-02
GO:BP	GO:0031399	regulation of protein modification process	4	1096	7.81e-02
GO:BP	GO:1902547	regulation of cellular response to vascular endothelial growth factor stimulus	1	20	7.83e-02
GO:BP	GO:0048011	neurotrophin TRK receptor signaling pathway	1	23	7.83e-02
GO:BP	GO:0036119	response to platelet-derived growth factor	1	22	7.83e-02
GO:BP	GO:0090162	establishment of epithelial cell polarity	1	30	7.91e-02
GO:BP	GO:0003417	growth plate cartilage development	1	14	8.01e-02
GO:BP	GO:1901798	positive regulation of signal transduction by p53 class mediator	1	28	8.02e-02
GO:BP	GO:0003091	renal water homeostasis	1	14	8.02e-02
GO:BP	GO:0070848	response to growth factor	3	571	8.31e-02
GO:BP	GO:0048511	rhythmic process	1	233	8.33e-02
GO:BP	GO:0043950	positive regulation of cAMP-mediated signaling	1	5	8.40e-02
GO:BP	GO:0009416	response to light stimulus	1	241	8.56e-02
GO:BP	GO:0070372	regulation of ERK1 and ERK2 cascade	2	192	8.56e-02
GO:BP	GO:0016567	protein ubiquitination	3	684	8.56e-02
GO:BP	GO:0046879	hormone secretion	1	212	8.56e-02
GO:BP	GO:0034260	negative regulation of GTPase activity	1	25	8.56e-02
GO:BP	GO:0060348	bone development	2	157	8.58e-02
GO:BP	GO:0060441	epithelial tube branching involved in lung morphogenesis	1	21	8.58e-02
GO:BP	GO:0021756	striatum development	1	18	8.58e-02
GO:BP	GO:0016053	organic acid biosynthetic process	1	224	8.58e-02
GO:BP	GO:0046394	carboxylic acid biosynthetic process	1	223	8.58e-02
GO:BP	GO:0009914	hormone transport	1	217	8.58e-02
GO:BP	GO:2000647	negative regulation of stem cell proliferation	1	18	8.58e-02
GO:BP	GO:1901873	regulation of post-translational protein modification	1	302	8.66e-02
GO:BP	GO:0003401	axis elongation	1	25	8.75e-02
GO:BP	GO:0015980	energy derivation by oxidation of organic compounds	1	288	8.75e-02
GO:BP	GO:0140013	meiotic nuclear division	2	117	8.80e-02
GO:BP	GO:0090287	regulation of cellular response to growth factor stimulus	2	261	8.80e-02
GO:BP	GO:0006833	water transport	1	12	8.80e-02
GO:BP	GO:0015849	organic acid transport	1	214	8.80e-02
GO:BP	GO:0046942	carboxylic acid transport	1	213	8.80e-02
GO:BP	GO:0040036	regulation of fibroblast growth factor receptor signaling pathway	1	25	8.80e-02
GO:BP	GO:0009306	protein secretion	1	262	8.92e-02
GO:BP	GO:0051098	regulation of binding	1	314	8.92e-02
GO:BP	GO:0048705	skeletal system morphogenesis	2	155	8.92e-02
GO:BP	GO:0009967	positive regulation of signal transduction	4	1116	8.92e-02
GO:BP	GO:0042886	amide transport	1	237	8.92e-02
GO:BP	GO:0035592	establishment of protein localization to extracellular region	1	262	8.92e-02
GO:BP	GO:0007423	sensory organ development	3	395	8.92e-02
GO:BP	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	1	36	8.92e-02
GO:BP	GO:0070371	ERK1 and ERK2 cascade	2	211	8.92e-02
GO:BP	GO:0070293	renal absorption	1	24	8.92e-02
GO:BP	GO:0032331	negative regulation of chondrocyte differentiation	1	18	8.95e-02
GO:BP	GO:0071692	protein localization to extracellular region	1	266	8.98e-02
GO:BP	GO:0007130	synaptonemal complex assembly	1	10	9.09e-02
GO:BP	GO:0050767	regulation of neurogenesis	1	302	9.15e-02
GO:BP	GO:0050891	multicellular organismal-level water homeostasis	1	17	9.23e-02
GO:BP	GO:0060317	cardiac epithelial to mesenchymal transition	1	28	9.23e-02
GO:BP	GO:0030212	hyaluronan metabolic process	1	21	9.23e-02
GO:BP	GO:0006631	fatty acid metabolic process	1	276	9.31e-02
GO:BP	GO:0032446	protein modification by small protein conjugation	3	759	9.36e-02
GO:BP	GO:0034405	response to fluid shear stress	1	31	9.36e-02
GO:BP	GO:0000132	establishment of mitotic spindle orientation	1	32	9.36e-02
GO:BP	GO:1903046	meiotic cell cycle process	2	132	9.48e-02
GO:BP	GO:0021544	subpallium development	1	19	9.48e-02
GO:BP	GO:0035116	embryonic hindlimb morphogenesis	1	17	9.48e-02
GO:BP	GO:0003416	endochondral bone growth	1	22	9.48e-02
GO:BP	GO:0006417	regulation of translation	1	373	9.51e-02
GO:BP	GO:0038179	neurotrophin signaling pathway	1	36	9.51e-02
GO:BP	GO:0070193	synaptonemal complex organization	1	13	9.51e-02
GO:BP	GO:0090311	regulation of protein deacetylation	1	44	9.51e-02
GO:BP	GO:0043010	camera-type eye development	2	237	9.51e-02
GO:BP	GO:0009314	response to radiation	1	339	9.51e-02
GO:BP	GO:0032885	regulation of polysaccharide biosynthetic process	1	32	9.51e-02
GO:BP	GO:0015711	organic anion transport	1	270	9.66e-02
GO:BP	GO:0042044	fluid transport	1	19	9.94e-02
GO:BP	GO:0098868	bone growth	1	23	1.01e-01
GO:BP	GO:0061037	negative regulation of cartilage development	1	23	1.01e-01
GO:BP	GO:0014911	positive regulation of smooth muscle cell migration	1	32	1.01e-01
GO:BP	GO:0051960	regulation of nervous system development	1	357	1.01e-01
GO:BP	GO:0040001	establishment of mitotic spindle localization	1	37	1.01e-01
GO:BP	GO:0038084	vascular endothelial growth factor signaling pathway	1	35	1.01e-01
GO:BP	GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	2	298	1.02e-01
GO:BP	GO:0051294	establishment of spindle orientation	1	37	1.02e-01
GO:BP	GO:0034248	regulation of amide metabolic process	1	426	1.02e-01
GO:BP	GO:0048566	embryonic digestive tract development	1	20	1.03e-01
GO:BP	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	1	28	1.03e-01
GO:BP	GO:0023061	signal release	1	329	1.03e-01
GO:BP	GO:0045596	negative regulation of cell differentiation	3	471	1.03e-01
GO:BP	GO:0048384	retinoic acid receptor signaling pathway	1	27	1.03e-01
GO:BP	GO:0032881	regulation of polysaccharide metabolic process	1	35	1.03e-01
GO:BP	GO:0085029	extracellular matrix assembly	1	36	1.03e-01
GO:BP	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	1	37	1.03e-01
GO:BP	GO:0060351	cartilage development involved in endochondral bone morphogenesis	1	25	1.04e-01
GO:BP	GO:0008015	blood circulation	1	372	1.04e-01
GO:BP	GO:0090066	regulation of anatomical structure size	1	395	1.05e-01
GO:BP	GO:0051223	regulation of protein transport	1	404	1.05e-01
GO:BP	GO:0006091	generation of precursor metabolites and energy	1	423	1.05e-01
GO:BP	GO:0048048	embryonic eye morphogenesis	1	25	1.05e-01
GO:BP	GO:1902531	regulation of intracellular signal transduction	4	1318	1.06e-01
GO:BP	GO:0002068	glandular epithelial cell development	1	28	1.06e-01
GO:BP	GO:0035137	hindlimb morphogenesis	1	21	1.06e-01
GO:BP	GO:0010837	regulation of keratinocyte proliferation	1	33	1.06e-01
GO:BP	GO:0090596	sensory organ morphogenesis	2	179	1.06e-01
GO:BP	GO:0006915	apoptotic process	3	1452	1.08e-01
GO:BP	GO:0046580	negative regulation of Ras protein signal transduction	1	46	1.08e-01
GO:BP	GO:0070201	regulation of establishment of protein localization	1	428	1.08e-01
GO:BP	GO:0010817	regulation of hormone levels	1	337	1.08e-01
GO:BP	GO:1901385	regulation of voltage-gated calcium channel activity	1	29	1.08e-01
GO:BP	GO:0044057	regulation of system process	1	398	1.08e-01
GO:BP	GO:0023056	positive regulation of signaling	4	1252	1.09e-01
GO:BP	GO:0010647	positive regulation of cell communication	4	1249	1.09e-01
GO:BP	GO:1901615	organic hydroxy compound metabolic process	1	375	1.09e-01
GO:BP	GO:0043949	regulation of cAMP-mediated signaling	1	17	1.09e-01
GO:BP	GO:1903530	regulation of secretion by cell	1	382	1.09e-01
GO:BP	GO:0060425	lung morphogenesis	1	39	1.10e-01
GO:BP	GO:0005975	carbohydrate metabolic process	1	439	1.10e-01
GO:BP	GO:0048562	embryonic organ morphogenesis	2	186	1.10e-01
GO:BP	GO:0030855	epithelial cell differentiation	3	439	1.10e-01
GO:BP	GO:0040020	regulation of meiotic nuclear division	1	19	1.11e-01
GO:BP	GO:0044283	small molecule biosynthetic process	1	432	1.11e-01
GO:BP	GO:2001258	negative regulation of cation channel activity	1	31	1.11e-01
GO:BP	GO:0003013	circulatory system process	1	445	1.11e-01
GO:BP	GO:0001932	regulation of protein phosphorylation	3	758	1.11e-01
GO:BP	GO:0034762	regulation of transmembrane transport	1	392	1.11e-01
GO:BP	GO:0012501	programmed cell death	3	1498	1.12e-01
GO:BP	GO:0070647	protein modification by small protein conjugation or removal	3	870	1.12e-01
GO:BP	GO:0008219	cell death	3	1504	1.12e-01
GO:BP	GO:0051058	negative regulation of small GTPase mediated signal transduction	1	52	1.14e-01
GO:BP	GO:0051046	regulation of secretion	1	413	1.14e-01
GO:BP	GO:1903170	negative regulation of calcium ion transmembrane transport	1	35	1.14e-01
GO:BP	GO:0032787	monocarboxylic acid metabolic process	1	434	1.14e-01
GO:BP	GO:0043407	negative regulation of MAP kinase activity	1	50	1.14e-01
GO:BP	GO:0001822	kidney development	2	246	1.16e-01
GO:BP	GO:0051293	establishment of spindle localization	1	49	1.18e-01
GO:BP	GO:0051239	regulation of multicellular organismal process	2	2052	1.18e-01
GO:BP	GO:0006338	chromatin remodeling	1	520	1.18e-01
GO:BP	GO:0031641	regulation of myelination	1	35	1.19e-01
GO:BP	GO:0072001	renal system development	2	253	1.20e-01
GO:BP	GO:1903053	regulation of extracellular matrix organization	1	47	1.20e-01
GO:BP	GO:0043616	keratinocyte proliferation	1	39	1.20e-01
GO:BP	GO:0035924	cellular response to vascular endothelial growth factor stimulus	1	54	1.21e-01
GO:BP	GO:0030330	DNA damage response, signal transduction by p53 class mediator	1	70	1.22e-01
GO:BP	GO:0023051	regulation of signaling	3	2560	1.22e-01
GO:BP	GO:0010646	regulation of cell communication	3	2567	1.23e-01
GO:BP	GO:0051653	spindle localization	1	53	1.23e-01
GO:BP	GO:0051321	meiotic cell cycle	2	183	1.24e-01
GO:BP	GO:1900024	regulation of substrate adhesion-dependent cell spreading	1	54	1.25e-01
GO:BP	GO:0002066	columnar/cuboidal epithelial cell development	1	39	1.30e-01
GO:BP	GO:0006476	protein deacetylation	1	81	1.31e-01
GO:BP	GO:0042325	regulation of phosphorylation	3	841	1.31e-01
GO:BP	GO:0006412	translation	1	657	1.32e-01
GO:BP	GO:0014910	regulation of smooth muscle cell migration	1	57	1.33e-01
GO:BP	GO:0032330	regulation of chondrocyte differentiation	1	36	1.33e-01
GO:BP	GO:0080134	regulation of response to stress	2	1074	1.34e-01
GO:BP	GO:0043043	peptide biosynthetic process	1	677	1.35e-01
GO:BP	GO:0006325	chromatin organization	1	631	1.35e-01
GO:BP	GO:0032940	secretion by cell	1	573	1.39e-01
GO:BP	GO:2000026	regulation of multicellular organismal development	4	997	1.39e-01
GO:BP	GO:0051926	negative regulation of calcium ion transport	1	45	1.39e-01
GO:BP	GO:0006024	glycosaminoglycan biosynthetic process	1	59	1.40e-01
GO:BP	GO:0060284	regulation of cell development	1	593	1.41e-01
GO:BP	GO:0007129	homologous chromosome pairing at meiosis	1	24	1.41e-01
GO:BP	GO:0042698	ovulation cycle	1	54	1.41e-01
GO:BP	GO:0006023	aminoglycan biosynthetic process	1	61	1.41e-01
GO:BP	GO:0014909	smooth muscle cell migration	1	64	1.41e-01
GO:BP	GO:0035601	protein deacylation	1	91	1.41e-01
GO:BP	GO:0008543	fibroblast growth factor receptor signaling pathway	1	59	1.42e-01
GO:BP	GO:0098732	macromolecule deacylation	1	92	1.42e-01
GO:BP	GO:0140962	multicellular organismal-level chemical homeostasis	1	48	1.42e-01
GO:BP	GO:0008285	negative regulation of cell population proliferation	1	643	1.42e-01
GO:BP	GO:0060350	endochondral bone morphogenesis	1	47	1.43e-01
GO:BP	GO:0071824	protein-DNA complex organization	1	711	1.43e-01
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	2	445	1.43e-01
GO:BP	GO:0032880	regulation of protein localization	1	719	1.43e-01
GO:BP	GO:0140352	export from cell	1	617	1.43e-01
GO:BP	GO:0007062	sister chromatid cohesion	1	52	1.43e-01
GO:BP	GO:0045913	positive regulation of carbohydrate metabolic process	1	61	1.44e-01
GO:BP	GO:0006518	peptide metabolic process	1	781	1.47e-01
GO:BP	GO:0043604	amide biosynthetic process	1	785	1.49e-01
GO:BP	GO:0071495	cellular response to endogenous stimulus	4	1097	1.49e-01
GO:BP	GO:0098657	import into cell	1	664	1.50e-01
GO:BP	GO:0032413	negative regulation of ion transmembrane transporter activity	1	52	1.50e-01
GO:BP	GO:0019752	carboxylic acid metabolic process	1	684	1.50e-01
GO:BP	GO:1901796	regulation of signal transduction by p53 class mediator	1	102	1.50e-01
GO:BP	GO:0046903	secretion	1	647	1.51e-01
GO:BP	GO:0006082	organic acid metabolic process	1	703	1.52e-01
GO:BP	GO:0043436	oxoacid metabolic process	1	699	1.52e-01
GO:BP	GO:0001570	vasculogenesis	1	67	1.52e-01
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	1	744	1.52e-01
GO:BP	GO:0019933	cAMP-mediated signaling	1	35	1.52e-01
GO:BP	GO:0060341	regulation of cellular localization	1	805	1.53e-01
GO:BP	GO:0014812	muscle cell migration	1	75	1.55e-01
GO:BP	GO:0045143	homologous chromosome segregation	1	32	1.55e-01
GO:BP	GO:0044255	cellular lipid metabolic process	1	736	1.55e-01
GO:BP	GO:0051174	regulation of phosphorus metabolic process	3	950	1.55e-01
GO:BP	GO:0019220	regulation of phosphate metabolic process	3	949	1.55e-01
GO:BP	GO:0006950	response to stress	3	2763	1.55e-01
GO:BP	GO:0070192	chromosome organization involved in meiotic cell cycle	1	35	1.55e-01
GO:BP	GO:0032410	negative regulation of transporter activity	1	59	1.58e-01
GO:BP	GO:0061035	regulation of cartilage development	1	53	1.58e-01
GO:BP	GO:0043687	post-translational protein modification	3	1102	1.58e-01
GO:BP	GO:0051093	negative regulation of developmental process	3	654	1.58e-01
GO:BP	GO:0033554	cellular response to stress	4	1662	1.59e-01
GO:BP	GO:0051480	regulation of cytosolic calcium ion concentration	1	39	1.59e-01
GO:BP	GO:0009893	positive regulation of metabolic process	2	2846	1.59e-01
GO:BP	GO:0016525	negative regulation of angiogenesis	1	71	1.59e-01
GO:BP	GO:0007264	small GTPase mediated signal transduction	2	413	1.59e-01
GO:BP	GO:0002067	glandular epithelial cell differentiation	1	49	1.59e-01
GO:BP	GO:0030335	positive regulation of cell migration	2	408	1.59e-01
GO:BP	GO:2000181	negative regulation of blood vessel morphogenesis	1	72	1.60e-01
GO:BP	GO:0090288	negative regulation of cellular response to growth factor stimulus	1	80	1.60e-01
GO:BP	GO:1901343	negative regulation of vasculature development	1	72	1.60e-01
GO:BP	GO:0010608	post-transcriptional regulation of gene expression	1	475	1.60e-01
GO:BP	GO:0009628	response to abiotic stimulus	1	848	1.61e-01
GO:BP	GO:0051445	regulation of meiotic cell cycle	1	45	1.61e-01
GO:BP	GO:1904063	negative regulation of cation transmembrane transport	1	64	1.61e-01
GO:BP	GO:1990823	response to leukemia inhibitory factor	1	87	1.61e-01
GO:BP	GO:1990830	cellular response to leukemia inhibitory factor	1	86	1.61e-01
GO:BP	GO:1903510	mucopolysaccharide metabolic process	1	75	1.61e-01
GO:BP	GO:0071901	negative regulation of protein serine/threonine kinase activity	1	96	1.63e-01
GO:BP	GO:0045859	regulation of protein kinase activity	2	473	1.63e-01
GO:BP	GO:0044344	cellular response to fibroblast growth factor stimulus	1	81	1.63e-01
GO:BP	GO:0033138	positive regulation of peptidyl-serine phosphorylation	1	68	1.63e-01
GO:BP	GO:0042472	inner ear morphogenesis	1	59	1.63e-01
GO:BP	GO:0043255	regulation of carbohydrate biosynthetic process	1	79	1.63e-01
GO:BP	GO:0045595	regulation of cell differentiation	4	1122	1.64e-01
GO:BP	GO:2000147	positive regulation of cell motility	2	421	1.64e-01
GO:BP	GO:0034446	substrate adhesion-dependent cell spreading	1	90	1.64e-01
GO:BP	GO:0043086	negative regulation of catalytic activity	2	456	1.64e-01
GO:BP	GO:0035556	intracellular signal transduction	5	2036	1.65e-01
GO:BP	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	1	78	1.65e-01
GO:BP	GO:1901019	regulation of calcium ion transmembrane transporter activity	1	70	1.67e-01
GO:BP	GO:0071774	response to fibroblast growth factor	1	85	1.69e-01
GO:BP	GO:0043603	amide metabolic process	1	1003	1.69e-01
GO:BP	GO:0034766	negative regulation of monoatomic ion transmembrane transport	1	70	1.69e-01
GO:BP	GO:0040017	positive regulation of locomotion	2	429	1.69e-01
GO:BP	GO:0048584	positive regulation of response to stimulus	4	1557	1.69e-01
GO:BP	GO:0048568	embryonic organ development	2	314	1.69e-01
GO:BP	GO:0071347	cellular response to interleukin-1	1	64	1.69e-01
GO:BP	GO:0072091	regulation of stem cell proliferation	1	58	1.74e-01
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	1	1005	1.80e-01
GO:BP	GO:0048869	cellular developmental process	3	2943	1.81e-01
GO:BP	GO:0030154	cell differentiation	3	2942	1.81e-01
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	1	1014	1.81e-01
GO:BP	GO:0030203	glycosaminoglycan metabolic process	1	87	1.81e-01
GO:BP	GO:0045132	meiotic chromosome segregation	1	51	1.83e-01
GO:BP	GO:0042471	ear morphogenesis	1	73	1.84e-01
GO:BP	GO:0048514	blood vessel morphogenesis	2	461	1.86e-01
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	5	1832	1.88e-01
GO:BP	GO:0003014	renal system process	1	76	1.89e-01
GO:BP	GO:0006629	lipid metabolic process	1	989	1.89e-01
GO:BP	GO:0009887	animal organ morphogenesis	3	725	1.90e-01
GO:BP	GO:0010811	positive regulation of cell-substrate adhesion	1	99	1.90e-01
GO:BP	GO:0001657	ureteric bud development	1	75	1.90e-01
GO:BP	GO:0006022	aminoglycan metabolic process	1	92	1.90e-01
GO:BP	GO:0072163	mesonephric epithelium development	1	76	1.91e-01
GO:BP	GO:0051253	negative regulation of RNA metabolic process	1	1112	1.91e-01
GO:BP	GO:0072164	mesonephric tubule development	1	76	1.91e-01
GO:BP	GO:0009719	response to endogenous stimulus	4	1260	1.92e-01
GO:BP	GO:0033135	regulation of peptidyl-serine phosphorylation	1	97	1.92e-01
GO:BP	GO:0043549	regulation of kinase activity	2	548	1.92e-01
GO:BP	GO:0019935	cyclic-nucleotide-mediated signaling	1	52	1.92e-01
GO:BP	GO:0001823	mesonephros development	1	77	1.96e-01
GO:BP	GO:0070555	response to interleukin-1	1	82	1.97e-01
GO:BP	GO:0051246	regulation of protein metabolic process	4	1895	1.98e-01
GO:BP	GO:0006468	protein phosphorylation	3	1130	1.98e-01
GO:BP	GO:0035295	tube development	3	822	1.98e-01
GO:BP	GO:0001501	skeletal system development	2	361	1.98e-01
GO:BP	GO:0000280	nuclear division	2	343	1.98e-01
GO:BP	GO:1901137	carbohydrate derivative biosynthetic process	2	544	1.98e-01
GO:BP	GO:0072331	signal transduction by p53 class mediator	1	163	1.98e-01
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	1	1203	2.00e-01
GO:BP	GO:0043271	negative regulation of monoatomic ion transport	1	88	2.00e-01
GO:BP	GO:0034763	negative regulation of transmembrane transport	1	96	2.00e-01
GO:BP	GO:0036211	protein modification process	5	2751	2.01e-01
GO:BP	GO:0051241	negative regulation of multicellular organismal process	3	744	2.01e-01
GO:BP	GO:0055085	transmembrane transport	1	1014	2.01e-01
GO:BP	GO:0048754	branching morphogenesis of an epithelial tube	1	121	2.06e-01
GO:BP	GO:0055007	cardiac muscle cell differentiation	1	108	2.06e-01
GO:BP	GO:0072359	circulatory system development	3	888	2.07e-01
GO:BP	GO:0042770	signal transduction in response to DNA damage	1	180	2.08e-01
GO:BP	GO:0002062	chondrocyte differentiation	1	89	2.08e-01
GO:BP	GO:0072089	stem cell proliferation	1	84	2.11e-01
GO:BP	GO:0007605	sensory perception of sound	1	97	2.11e-01
GO:BP	GO:0010634	positive regulation of epithelial cell migration	1	132	2.11e-01
GO:BP	GO:0007267	cell-cell signaling	1	1150	2.11e-01
GO:BP	GO:0002065	columnar/cuboidal epithelial cell differentiation	1	80	2.11e-01
GO:BP	GO:0051896	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	1	123	2.11e-01
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	1	1298	2.11e-01
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	1	1305	2.11e-01
GO:BP	GO:0022008	neurogenesis	1	1297	2.11e-01
GO:BP	GO:0001568	blood vessel development	2	537	2.12e-01
GO:BP	GO:0035113	embryonic appendage morphogenesis	1	89	2.13e-01
GO:BP	GO:2001257	regulation of cation channel activity	1	100	2.13e-01
GO:BP	GO:0030326	embryonic limb morphogenesis	1	89	2.13e-01
GO:BP	GO:1902850	microtubule cytoskeleton organization involved in mitosis	1	157	2.14e-01
GO:BP	GO:0051049	regulation of transport	1	1268	2.15e-01
GO:BP	GO:0009101	glycoprotein biosynthetic process	1	251	2.17e-01
GO:BP	GO:0034502	protein localization to chromosome	1	101	2.19e-01
GO:BP	GO:1901566	organonitrogen compound biosynthetic process	1	1496	2.20e-01
GO:BP	GO:0048285	organelle fission	2	387	2.20e-01
GO:BP	GO:0015031	protein transport	1	1366	2.20e-01
GO:BP	GO:0001944	vasculature development	2	562	2.21e-01
GO:BP	GO:0044281	small molecule metabolic process	1	1386	2.22e-01
GO:BP	GO:0051254	positive regulation of RNA metabolic process	1	1425	2.22e-01
GO:BP	GO:0007507	heart development	2	512	2.24e-01
GO:BP	GO:0043405	regulation of MAP kinase activity	1	141	2.24e-01
GO:BP	GO:0048565	digestive tract development	1	92	2.26e-01
GO:BP	GO:0050954	sensory perception of mechanical stimulus	1	111	2.26e-01
GO:BP	GO:0046578	regulation of Ras protein signal transduction	1	156	2.26e-01
GO:BP	GO:0045184	establishment of protein localization	1	1468	2.27e-01
GO:BP	GO:0031345	negative regulation of cell projection organization	1	154	2.27e-01
GO:BP	GO:0030324	lung development	1	144	2.27e-01
GO:BP	GO:0007127	meiosis I	1	73	2.27e-01
GO:BP	GO:0061138	morphogenesis of a branching epithelium	1	143	2.27e-01
GO:BP	GO:0043412	macromolecule modification	5	2948	2.29e-01
GO:BP	GO:0051338	regulation of transferase activity	2	664	2.29e-01
GO:BP	GO:0030323	respiratory tube development	1	148	2.29e-01
GO:BP	GO:0048598	embryonic morphogenesis	2	438	2.31e-01
GO:BP	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	1	144	2.32e-01
GO:BP	GO:0061982	meiosis I cell cycle process	1	77	2.34e-01
GO:BP	GO:0042552	myelination	1	114	2.35e-01
GO:BP	GO:0055123	digestive system development	1	100	2.36e-01
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	1	1589	2.36e-01
GO:BP	GO:0007272	ensheathment of neurons	1	116	2.36e-01
GO:BP	GO:0060429	epithelium development	3	849	2.36e-01
GO:BP	GO:0008366	axon ensheathment	1	116	2.36e-01
GO:BP	GO:0048839	inner ear development	1	129	2.36e-01
GO:BP	GO:0006109	regulation of carbohydrate metabolic process	1	147	2.36e-01
GO:BP	GO:0035051	cardiocyte differentiation	1	134	2.36e-01
GO:BP	GO:0001763	morphogenesis of a branching structure	1	155	2.37e-01
GO:BP	GO:0035108	limb morphogenesis	1	113	2.37e-01
GO:BP	GO:0035107	appendage morphogenesis	1	113	2.37e-01
GO:BP	GO:0072073	kidney epithelium development	1	113	2.40e-01
GO:BP	GO:0032879	regulation of localization	1	1570	2.41e-01
GO:BP	GO:0016310	phosphorylation	3	1338	2.41e-01
GO:BP	GO:0070374	positive regulation of ERK1 and ERK2 cascade	1	120	2.42e-01
GO:BP	GO:0060541	respiratory system development	1	161	2.42e-01
GO:BP	GO:0035264	multicellular organism growth	1	124	2.42e-01
GO:BP	GO:0065009	regulation of molecular function	2	1905	2.43e-01
GO:BP	GO:0008033	tRNA processing	1	131	2.43e-01
GO:BP	GO:1903169	regulation of calcium ion transmembrane transport	1	120	2.43e-01
GO:BP	GO:0009100	glycoprotein metabolic process	1	315	2.44e-01
GO:BP	GO:0048589	developmental growth	2	522	2.44e-01
GO:BP	GO:0042127	regulation of cell population proliferation	1	1568	2.44e-01
GO:BP	GO:0071345	cellular response to cytokine stimulus	2	544	2.45e-01
GO:BP	GO:0003008	system process	1	1194	2.51e-01
GO:BP	GO:0050679	positive regulation of epithelial cell proliferation	1	152	2.52e-01
GO:BP	GO:0071705	nitrogen compound transport	1	1689	2.53e-01
GO:BP	GO:0009888	tissue development	4	1425	2.54e-01
GO:BP	GO:0043583	ear development	1	150	2.55e-01
GO:BP	GO:0061351	neural precursor cell proliferation	1	122	2.55e-01
GO:BP	GO:0048592	eye morphogenesis	1	114	2.55e-01
GO:BP	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	1	71	2.56e-01
GO:BP	GO:0010810	regulation of cell-substrate adhesion	1	171	2.58e-01
GO:BP	GO:0051783	regulation of nuclear division	1	115	2.60e-01
GO:BP	GO:0051649	establishment of localization in cell	1	1842	2.60e-01
GO:BP	GO:0035239	tube morphogenesis	2	663	2.60e-01
GO:BP	GO:0048522	positive regulation of cellular process	2	4197	2.60e-01
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	1	1764	2.61e-01
GO:BP	GO:0007167	enzyme-linked receptor protein signaling pathway	2	741	2.64e-01
GO:BP	GO:0050793	regulation of developmental process	1	1813	2.66e-01
GO:BP	GO:0060560	developmental growth involved in morphogenesis	1	207	2.68e-01
GO:BP	GO:0010632	regulation of epithelial cell migration	1	195	2.68e-01
GO:BP	GO:0071356	cellular response to tumor necrosis factor	1	159	2.69e-01
GO:BP	GO:0007399	nervous system development	1	1886	2.69e-01
GO:BP	GO:0006366	transcription by RNA polymerase II	1	1852	2.70e-01
GO:BP	GO:0048736	appendage development	1	141	2.72e-01
GO:BP	GO:0060173	limb development	1	141	2.72e-01
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	1	1896	2.76e-01
GO:BP	GO:0034097	response to cytokine	2	609	2.77e-01
GO:BP	GO:0009755	hormone-mediated signaling pathway	1	142	2.82e-01
GO:BP	GO:0030334	regulation of cell migration	2	707	2.82e-01
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	1	1958	2.83e-01
GO:BP	GO:0009605	response to external stimulus	1	1635	2.83e-01
GO:BP	GO:0009891	positive regulation of biosynthetic process	1	1972	2.85e-01
GO:BP	GO:0034612	response to tumor necrosis factor	1	176	2.85e-01
GO:BP	GO:0008104	protein localization	1	2128	2.86e-01
GO:BP	GO:0070727	cellular macromolecule localization	1	2137	2.87e-01
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	1	1669	2.87e-01
GO:BP	GO:0048468	cell development	1	1950	2.88e-01
GO:BP	GO:0009966	regulation of signal transduction	4	2271	2.90e-01
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	1	1708	2.91e-01
GO:BP	GO:0045765	regulation of angiogenesis	1	200	2.91e-01
GO:BP	GO:0051216	cartilage development	1	149	2.91e-01
GO:BP	GO:0009890	negative regulation of biosynthetic process	1	1721	2.91e-01
GO:BP	GO:1901342	regulation of vasculature development	1	202	2.92e-01
GO:BP	GO:0003007	heart morphogenesis	1	217	2.92e-01
GO:BP	GO:0045165	cell fate commitment	1	157	2.94e-01
GO:BP	GO:0002064	epithelial cell development	1	156	2.95e-01
GO:BP	GO:0048518	positive regulation of biological process	2	4566	2.95e-01
GO:BP	GO:1903039	positive regulation of leukocyte cell-cell adhesion	1	157	2.95e-01
GO:BP	GO:0018193	peptidyl-amino acid modification	2	866	2.98e-01
GO:BP	GO:0065008	regulation of biological quality	1	2085	2.98e-01
GO:BP	GO:2000145	regulation of cell motility	2	741	2.98e-01
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	1	249	3.00e-01
GO:BP	GO:0051924	regulation of calcium ion transport	1	167	3.02e-01
GO:BP	GO:0023052	signaling	2	4134	3.05e-01
GO:BP	GO:0018105	peptidyl-serine phosphorylation	1	242	3.06e-01
GO:BP	GO:0032502	developmental process	2	4445	3.06e-01
GO:BP	GO:0071702	organic substance transport	1	2133	3.06e-01
GO:BP	GO:0048738	cardiac muscle tissue development	1	202	3.06e-01
GO:BP	GO:0006399	tRNA metabolic process	1	189	3.06e-01
GO:BP	GO:0051346	negative regulation of hydrolase activity	1	206	3.07e-01
GO:BP	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	1	189	3.07e-01
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	1	2367	3.07e-01
GO:BP	GO:0007154	cell communication	2	4210	3.10e-01
GO:BP	GO:0040012	regulation of locomotion	2	762	3.10e-01
GO:BP	GO:0018209	peptidyl-serine modification	1	254	3.17e-01
GO:BP	GO:0022898	regulation of transmembrane transporter activity	1	200	3.17e-01
GO:BP	GO:0022402	cell cycle process	3	1078	3.17e-01
GO:BP	GO:0014706	striated muscle tissue development	1	214	3.17e-01
GO:BP	GO:0031324	negative regulation of cellular metabolic process	1	2069	3.17e-01
GO:BP	GO:0019538	protein metabolic process	6	4202	3.17e-01
GO:BP	GO:1901135	carbohydrate derivative metabolic process	2	841	3.17e-01
GO:BP	GO:0008283	cell population proliferation	1	2340	3.17e-01
GO:BP	GO:0033036	macromolecule localization	1	2448	3.17e-01
GO:BP	GO:0010631	epithelial cell migration	1	253	3.17e-01
GO:BP	GO:2000241	regulation of reproductive process	1	126	3.19e-01
GO:BP	GO:0090132	epithelium migration	1	253	3.19e-01
GO:BP	GO:0007265	Ras protein signal transduction	1	287	3.20e-01
GO:BP	GO:0060562	epithelial tube morphogenesis	1	276	3.20e-01
GO:BP	GO:0090130	tissue migration	1	257	3.23e-01
GO:BP	GO:0022409	positive regulation of cell-cell adhesion	1	188	3.23e-01
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	1	2131	3.24e-01
GO:BP	GO:0032409	regulation of transporter activity	1	212	3.26e-01
GO:BP	GO:0030198	extracellular matrix organization	1	233	3.27e-01
GO:BP	GO:0043062	extracellular structure organization	1	234	3.27e-01
GO:BP	GO:0071900	regulation of protein serine/threonine kinase activity	1	274	3.27e-01
GO:BP	GO:0045229	external encapsulating structure organization	1	234	3.27e-01
GO:BP	GO:0031325	positive regulation of cellular metabolic process	1	2518	3.27e-01
GO:BP	GO:0006355	regulation of DNA-templated transcription	1	2560	3.30e-01
GO:BP	GO:2001141	regulation of RNA biosynthetic process	1	2577	3.31e-01
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	1	2607	3.33e-01
GO:BP	GO:0043087	regulation of GTPase activity	1	288	3.33e-01
GO:BP	GO:0009892	negative regulation of metabolic process	1	2297	3.39e-01
GO:BP	GO:0006351	DNA-templated transcription	1	2669	3.39e-01
GO:BP	GO:0032774	RNA biosynthetic process	1	2699	3.42e-01
GO:BP	GO:0031589	cell-substrate adhesion	1	271	3.45e-01
GO:BP	GO:0021537	telencephalon development	1	208	3.45e-01
GO:BP	GO:0051641	cellular localization	1	2822	3.45e-01
GO:BP	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	1	113	3.47e-01
GO:BP	GO:0061448	connective tissue development	1	212	3.49e-01
GO:BP	GO:0009968	negative regulation of signal transduction	2	1017	3.50e-01
GO:BP	GO:0040007	growth	2	737	3.50e-01
GO:BP	GO:0051146	striated muscle cell differentiation	1	239	3.50e-01
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	1	232	3.51e-01
GO:BP	GO:0051252	regulation of RNA metabolic process	1	2824	3.51e-01
GO:BP	GO:0050678	regulation of epithelial cell proliferation	1	268	3.53e-01
GO:BP	GO:1903037	regulation of leukocyte cell-cell adhesion	1	210	3.53e-01
GO:BP	GO:0050878	regulation of body fluid levels	1	237	3.53e-01
GO:BP	GO:0019222	regulation of metabolic process	2	4998	3.64e-01
GO:BP	GO:0048731	system development	1	2886	3.67e-01
GO:BP	GO:0070588	calcium ion transmembrane transport	1	221	3.68e-01
GO:BP	GO:0040011	locomotion	2	854	3.72e-01
GO:BP	GO:0043933	protein-containing complex organization	1	1964	3.72e-01
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	1	3054	3.72e-01
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	1	3059	3.72e-01
GO:BP	GO:0018130	heterocycle biosynthetic process	1	3115	3.77e-01
GO:BP	GO:0019438	aromatic compound biosynthetic process	1	3116	3.77e-01
GO:BP	GO:0007159	leukocyte cell-cell adhesion	1	233	3.77e-01
GO:BP	GO:1901564	organonitrogen compound metabolic process	7	4919	3.79e-01
GO:BP	GO:0010648	negative regulation of cell communication	2	1088	3.83e-01
GO:BP	GO:0023057	negative regulation of signaling	2	1090	3.83e-01
GO:BP	GO:0098813	nuclear chromosome segregation	1	264	3.86e-01
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	1	3221	3.87e-01
GO:BP	GO:0030522	intracellular receptor signaling pathway	1	256	3.91e-01
GO:BP	GO:0032501	multicellular organismal process	2	4807	3.91e-01
GO:BP	GO:0051656	establishment of organelle localization	1	397	3.93e-01
GO:BP	GO:0001667	ameboidal-type cell migration	1	358	3.93e-01
GO:BP	GO:0019932	second-messenger-mediated signaling	1	182	3.94e-01
GO:BP	GO:0010959	regulation of metal ion transport	1	271	3.95e-01
GO:BP	GO:0022414	reproductive process	3	924	3.99e-01
GO:BP	GO:0048583	regulation of response to stimulus	2	2877	3.99e-01
GO:BP	GO:0050673	epithelial cell proliferation	1	318	3.99e-01
GO:BP	GO:0000003	reproduction	3	933	4.02e-01
GO:BP	GO:0007275	multicellular organism development	1	3355	4.13e-01
GO:BP	GO:0006874	intracellular calcium ion homeostasis	1	208	4.13e-01
GO:BP	GO:0051051	negative regulation of transport	1	317	4.16e-01
GO:BP	GO:0022407	regulation of cell-cell adhesion	1	292	4.19e-01
GO:BP	GO:0045785	positive regulation of cell adhesion	1	319	4.19e-01
GO:BP	GO:0006810	transport	1	3294	4.19e-01
GO:BP	GO:0002009	morphogenesis of an epithelium	1	415	4.24e-01
GO:BP	GO:0001525	angiogenesis	1	389	4.24e-01
GO:BP	GO:0009790	embryo development	2	859	4.24e-01
GO:BP	GO:0042692	muscle cell differentiation	1	329	4.24e-01
GO:BP	GO:0006816	calcium ion transport	1	275	4.24e-01
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	1	3743	4.28e-01
GO:BP	GO:0055074	calcium ion homeostasis	1	221	4.31e-01
GO:BP	GO:0051234	establishment of localization	1	3453	4.31e-01
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	6	4243	4.35e-01
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	1	296	4.35e-01
GO:BP	GO:0060537	muscle tissue development	1	347	4.41e-01
GO:BP	GO:0030900	forebrain development	1	290	4.42e-01
GO:BP	GO:0006796	phosphate-containing compound metabolic process	3	2096	4.46e-01
GO:BP	GO:0016477	cell migration	2	1065	4.50e-01
GO:BP	GO:0006793	phosphorus metabolic process	3	2118	4.52e-01
GO:BP	GO:0071310	cellular response to organic substance	3	1390	4.53e-01
GO:BP	GO:0048585	negative regulation of response to stimulus	2	1267	4.58e-01
GO:BP	GO:0048878	chemical homeostasis	2	689	4.58e-01
GO:BP	GO:0007059	chromosome segregation	1	360	4.58e-01
GO:BP	GO:0051640	organelle localization	1	521	4.61e-01
GO:BP	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	1	470	4.67e-01
GO:BP	GO:0080090	regulation of primary metabolic process	6	4371	4.69e-01
GO:BP	GO:0010468	regulation of gene expression	1	3587	4.73e-01
GO:BP	GO:0048523	negative regulation of cellular process	1	3773	4.73e-01
GO:BP	GO:0048729	tissue morphogenesis	1	501	4.75e-01
GO:BP	GO:0051179	localization	1	3983	4.75e-01
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	1	3702	4.81e-01
GO:BP	GO:0031344	regulation of cell projection organization	1	542	4.85e-01
GO:BP	GO:0000226	microtubule cytoskeleton organization	1	549	4.85e-01
GO:BP	GO:0019953	sexual reproduction	2	633	4.85e-01
GO:BP	GO:0001934	positive regulation of protein phosphorylation	1	465	4.89e-01
GO:BP	GO:0031326	regulation of cellular biosynthetic process	1	3794	4.89e-01
GO:BP	GO:0034470	ncRNA processing	1	397	4.89e-01
GO:BP	GO:0009889	regulation of biosynthetic process	1	3820	4.90e-01
GO:BP	GO:0048856	anatomical structure development	1	4100	4.95e-01
GO:BP	GO:0050790	regulation of catalytic activity	1	1349	4.95e-01
GO:BP	GO:0043269	regulation of monoatomic ion transport	1	369	4.97e-01
GO:BP	GO:0050896	response to stimulus	2	5721	4.97e-01
GO:BP	GO:0048519	negative regulation of biological process	1	4026	4.97e-01
GO:BP	GO:0051129	negative regulation of cellular component organization	1	592	5.08e-01
GO:BP	GO:0048870	cell motility	2	1169	5.08e-01
GO:BP	GO:0048513	animal organ development	4	2156	5.11e-01
GO:BP	GO:0042327	positive regulation of phosphorylation	1	511	5.16e-01
GO:BP	GO:0006974	DNA damage response	1	795	5.18e-01
GO:BP	GO:1903047	mitotic cell cycle process	1	689	5.30e-01
GO:BP	GO:0045937	positive regulation of phosphate metabolic process	1	559	5.50e-01
GO:BP	GO:0010562	positive regulation of phosphorus metabolic process	1	559	5.50e-01
GO:BP	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1	288	5.55e-01
GO:BP	GO:0000398	mRNA splicing, via spliceosome	1	288	5.55e-01
GO:BP	GO:0000375	RNA splicing, via transesterification reactions	1	292	5.55e-01
GO:BP	GO:0032870	cellular response to hormone stimulus	1	449	5.55e-01
GO:BP	GO:0031323	regulation of cellular metabolic process	1	4563	5.55e-01
GO:BP	GO:0060255	regulation of macromolecule metabolic process	1	4593	5.58e-01
GO:BP	GO:0030003	intracellular monoatomic cation homeostasis	1	364	5.62e-01
GO:BP	GO:0030155	regulation of cell adhesion	1	535	5.64e-01
GO:BP	GO:0098771	inorganic ion homeostasis	1	355	5.66e-01
GO:BP	GO:0006873	intracellular monoatomic ion homeostasis	1	369	5.67e-01
GO:BP	GO:0016070	RNA metabolic process	1	3573	5.68e-01
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	1	680	5.73e-01
GO:BP	GO:0043066	negative regulation of apoptotic process	1	662	5.79e-01
GO:BP	GO:0008380	RNA splicing	1	426	5.79e-01
GO:BP	GO:0031401	positive regulation of protein modification process	1	664	5.81e-01
GO:BP	GO:0000278	mitotic cell cycle	1	815	5.86e-01
GO:BP	GO:0061061	muscle structure development	1	552	5.86e-01
GO:BP	GO:0043069	negative regulation of programmed cell death	1	685	5.86e-01
GO:BP	GO:0006397	mRNA processing	1	451	5.86e-01
GO:BP	GO:0051276	chromosome organization	1	533	5.87e-01
GO:BP	GO:0007600	sensory perception	1	259	6.00e-01
GO:BP	GO:0034660	ncRNA metabolic process	1	561	6.00e-01
GO:BP	GO:0051301	cell division	1	569	6.00e-01
GO:BP	GO:0007017	microtubule-based process	1	757	6.00e-01
GO:BP	GO:0051336	regulation of hydrolase activity	1	680	6.00e-01
GO:BP	GO:0090304	nucleic acid metabolic process	1	4018	6.00e-01
GO:BP	GO:0055080	monoatomic cation homeostasis	1	410	6.01e-01
GO:BP	GO:0050801	monoatomic ion homeostasis	1	416	6.06e-01
GO:BP	GO:0048609	multicellular organismal reproductive process	1	538	6.11e-01
GO:BP	GO:0007420	brain development	1	546	6.19e-01
GO:BP	GO:0098662	inorganic cation transmembrane transport	1	537	6.19e-01
GO:BP	GO:0098609	cell-cell adhesion	1	599	6.24e-01
GO:BP	GO:0016071	mRNA metabolic process	1	671	6.26e-01
GO:BP	GO:0098655	monoatomic cation transmembrane transport	1	554	6.28e-01
GO:BP	GO:0032504	multicellular organism reproduction	1	558	6.28e-01
GO:BP	GO:0044087	regulation of cellular component biogenesis	1	802	6.30e-01
GO:BP	GO:0007165	signal transduction	2	3803	6.30e-01
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	1	4423	6.31e-01
GO:BP	GO:0030001	metal ion transport	1	568	6.34e-01
GO:BP	GO:0009653	anatomical structure morphogenesis	3	1952	6.34e-01
GO:BP	GO:0060322	head development	1	588	6.35e-01
GO:BP	GO:0070887	cellular response to chemical stimulus	3	1857	6.35e-01
GO:BP	GO:0016043	cellular component organization	1	5106	6.35e-01
GO:BP	GO:0046483	heterocycle metabolic process	1	4537	6.40e-01
GO:BP	GO:0006725	cellular aromatic compound metabolic process	1	4561	6.43e-01
GO:BP	GO:0098660	inorganic ion transmembrane transport	1	582	6.48e-01
GO:BP	GO:0071840	cellular component organization or biogenesis	1	5307	6.49e-01
GO:BP	GO:0010033	response to organic substance	3	1942	6.54e-01
GO:BP	GO:0055082	intracellular chemical homeostasis	1	498	6.55e-01
GO:BP	GO:1901360	organic cyclic compound metabolic process	1	4713	6.57e-01
GO:BP	GO:0009725	response to hormone	1	624	6.59e-01
GO:BP	GO:0010564	regulation of cell cycle process	1	622	6.59e-01
GO:BP	GO:0048646	anatomical structure formation involved in morphogenesis	1	868	6.62e-01
GO:BP	GO:0010628	positive regulation of gene expression	1	795	6.65e-01
GO:BP	GO:0034641	cellular nitrogen compound metabolic process	1	4913	6.66e-01
GO:BP	GO:0051128	regulation of cellular component organization	3	1981	6.77e-01
GO:BP	GO:0034220	monoatomic ion transmembrane transport	1	650	6.81e-01
GO:BP	GO:0006812	monoatomic cation transport	1	677	6.86e-01
GO:BP	GO:0019725	cellular homeostasis	1	583	7.01e-01
GO:BP	GO:0010467	gene expression	1	4733	7.05e-01
GO:BP	GO:0008284	positive regulation of cell population proliferation	1	886	7.14e-01
GO:BP	GO:0051247	positive regulation of protein metabolic process	1	1067	7.19e-01
GO:BP	GO:0007166	cell surface receptor signaling pathway	2	1889	7.19e-01
GO:BP	GO:0007417	central nervous system development	1	750	7.22e-01
GO:BP	GO:0009059	macromolecule biosynthetic process	1	5148	7.39e-01
GO:BP	GO:0007010	cytoskeleton organization	1	1186	7.39e-01
GO:BP	GO:0050877	nervous system process	1	628	7.47e-01
GO:BP	GO:0006811	monoatomic ion transport	1	788	7.50e-01
GO:BP	GO:0030030	cell projection organization	1	1236	7.67e-01
GO:BP	GO:0050794	regulation of cellular process	2	7632	7.71e-01
GO:BP	GO:0051716	cellular response to stimulus	2	4929	7.73e-01
GO:BP	GO:0007155	cell adhesion	1	996	7.76e-01
GO:BP	GO:0006396	RNA processing	1	928	7.79e-01
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	1	918	7.83e-01
GO:BP	GO:0033365	protein localization to organelle	1	860	7.85e-01
GO:BP	GO:0044249	cellular biosynthetic process	1	5813	7.93e-01
GO:BP	GO:1901576	organic substance biosynthetic process	1	5875	7.99e-01
GO:BP	GO:0009058	biosynthetic process	1	5912	8.02e-01
GO:BP	GO:0033043	regulation of organelle organization	1	1001	8.14e-01
GO:BP	GO:0050789	regulation of biological process	2	8017	8.37e-01
GO:BP	GO:0007186	G protein-coupled receptor signaling pathway	1	386	8.37e-01
GO:BP	GO:0042221	response to chemical	3	2456	8.73e-01
GO:BP	GO:0065007	biological regulation	2	8282	8.93e-01
GO:BP	GO:0006996	organelle organization	3	2974	8.99e-01
GO:BP	GO:0006807	nitrogen compound metabolic process	1	7431	9.01e-01
GO:BP	GO:0043170	macromolecule metabolic process	1	7084	9.16e-01
GO:BP	GO:0044238	primary metabolic process	1	7788	9.40e-01
GO:BP	GO:0044237	cellular metabolic process	1	7562	9.57e-01
GO:BP	GO:0022607	cellular component assembly	2	2459	9.95e-01
GO:BP	GO:0044085	cellular component biogenesis	2	2722	9.97e-01
GO:BP	GO:0009987	cellular process	1	11410	1.00e+00
GO:BP	GO:0008152	metabolic process	1	8522	1.00e+00
GO:BP	GO:0008150	biological_process	1	12027	1.00e+00
GO:BP	GO:0071704	organic substance metabolic process	1	8176	1.00e+00
KEGG	KEGG:05202	Transcriptional misregulation in cancer	3	128	3.30e-04
KEGG	KEGG:04115	p53 signaling pathway	2	65	5.02e-04
KEGG	KEGG:05223	Non-small cell lung cancer	3	67	5.02e-04
KEGG	KEGG:05212	Pancreatic cancer	2	75	5.02e-04
KEGG	KEGG:05222	Small cell lung cancer	3	87	5.02e-04
KEGG	KEGG:05213	Endometrial cancer	2	57	5.02e-04
KEGG	KEGG:05214	Glioma	2	67	5.02e-04
KEGG	KEGG:05216	Thyroid cancer	2	35	5.02e-04
KEGG	KEGG:05220	Chronic myeloid leukemia	2	75	5.02e-04
KEGG	KEGG:05217	Basal cell carcinoma	2	49	5.02e-04
KEGG	KEGG:05218	Melanoma	2	58	5.02e-04
KEGG	KEGG:05210	Colorectal cancer	2	84	5.89e-04
KEGG	KEGG:04064	NF-kappa B signaling pathway	2	71	7.65e-04
KEGG	KEGG:05226	Gastric cancer	3	117	1.09e-03
KEGG	KEGG:04210	Apoptosis	2	118	1.09e-03
KEGG	KEGG:04068	FoxO signaling pathway	2	109	1.09e-03
KEGG	KEGG:05224	Breast cancer	2	117	1.21e-03
KEGG	KEGG:04218	Cellular senescence	2	145	1.24e-03
KEGG	KEGG:04110	Cell cycle	2	151	1.24e-03
KEGG	KEGG:05225	Hepatocellular carcinoma	2	145	1.31e-03
KEGG	KEGG:05169	Epstein-Barr virus infection	2	153	1.78e-03
KEGG	KEGG:04710	Circadian rhythm	1	30	3.41e-03
KEGG	KEGG:04010	MAPK signaling pathway	2	240	3.55e-03
KEGG	KEGG:05221	Acute myeloid leukemia	1	56	6.16e-03
KEGG	KEGG:04713	Circadian entrainment	1	69	8.57e-03
KEGG	KEGG:05200	Pathways in cancer	2	409	9.94e-03
KEGG	KEGG:04114	Oocyte meiosis	1	108	1.57e-01
KEGG	KEGG:05206	MicroRNAs in cancer	1	149	2.40e-01
KEGG	KEGG:05168	Herpes simplex virus 1 infection	1	415	2.41e-01
KEGG	KEGG:00000	KEGG root term	2	5548	3.61e-01

TRZnomtable3h %>%
  filter(source=="KEGG") %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "Enrichment of KEGG terms using nominal pvalue TRZ 3hour genes in my data") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

Enrichment of KEGG terms using nominal pvalue TRZ 3hour genes in my data
source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:05202	Transcriptional misregulation in cancer	3	128	3.30e-04
KEGG	KEGG:04115	p53 signaling pathway	2	65	5.02e-04
KEGG	KEGG:05223	Non-small cell lung cancer	3	67	5.02e-04
KEGG	KEGG:05212	Pancreatic cancer	2	75	5.02e-04
KEGG	KEGG:05222	Small cell lung cancer	3	87	5.02e-04
KEGG	KEGG:05213	Endometrial cancer	2	57	5.02e-04
KEGG	KEGG:05214	Glioma	2	67	5.02e-04
KEGG	KEGG:05216	Thyroid cancer	2	35	5.02e-04
KEGG	KEGG:05220	Chronic myeloid leukemia	2	75	5.02e-04
KEGG	KEGG:05217	Basal cell carcinoma	2	49	5.02e-04
KEGG	KEGG:05218	Melanoma	2	58	5.02e-04
KEGG	KEGG:05210	Colorectal cancer	2	84	5.89e-04
KEGG	KEGG:04064	NF-kappa B signaling pathway	2	71	7.65e-04
KEGG	KEGG:05226	Gastric cancer	3	117	1.09e-03
KEGG	KEGG:04210	Apoptosis	2	118	1.09e-03
KEGG	KEGG:04068	FoxO signaling pathway	2	109	1.09e-03
KEGG	KEGG:05224	Breast cancer	2	117	1.21e-03
KEGG	KEGG:04218	Cellular senescence	2	145	1.24e-03
KEGG	KEGG:04110	Cell cycle	2	151	1.24e-03
KEGG	KEGG:05225	Hepatocellular carcinoma	2	145	1.31e-03
KEGG	KEGG:05169	Epstein-Barr virus infection	2	153	1.78e-03
KEGG	KEGG:04710	Circadian rhythm	1	30	3.41e-03
KEGG	KEGG:04010	MAPK signaling pathway	2	240	3.55e-03
KEGG	KEGG:05221	Acute myeloid leukemia	1	56	6.16e-03
KEGG	KEGG:04713	Circadian entrainment	1	69	8.57e-03
KEGG	KEGG:05200	Pathways in cancer	2	409	9.94e-03
KEGG	KEGG:04114	Oocyte meiosis	1	108	1.57e-01
KEGG	KEGG:05206	MicroRNAs in cancer	1	149	2.40e-01
KEGG	KEGG:05168	Herpes simplex virus 1 infection	1	415	2.41e-01
KEGG	KEGG:00000	KEGG root term	2	5548	3.61e-01

TRZ 24 hour nom de

# TRZresgenes24h <- gost(query = TRZ_list24h$ENTREZID,
#                     organism = "hsapiens",
#                     significant = FALSE,
#                     ordered_query = TRUE,
#                     domain_scope = "custom",
#                     measure_underrepresentation = FALSE,
#                     evcodes = FALSE,
#                     user_threshold = 0.05,
#                     correction_method = c("fdr"),
#                     custom_bg = backGL$ENTREZID,
#                     sources=c("GO:BP","KEGG"))
# saveRDS(TRZresgenes24h,"data/DEG-GO/TRZresgenes24h.RDS")
TRZresgenes24h <- readRDS("data/DEG-GO/TRZresgenes24h.RDS")

TRZnom24h <- gostplot(TRZresgenes24h, capped = FALSE, interactive = TRUE)
TRZnom24h

TRZnomtable24h <- TRZresgenes24h$result %>% 
  dplyr::select(c(source, term_id,
                  term_name,intersection_size, 
                   term_size, p_value))# %>% 

TRZnomtable24h %>%
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., ) %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

source	term_id	term_name	intersection_size	term_size	p_value
GO:BP	GO:0098728	germline stem cell asymmetric division	1	2	6.00e-02
GO:BP	GO:0048133	male germ-line stem cell asymmetric division	1	2	6.00e-02
GO:BP	GO:0042078	germ-line stem cell division	1	2	6.00e-02
GO:BP	GO:0098722	asymmetric stem cell division	1	2	6.00e-02
GO:BP	GO:0015757	galactose transmembrane transport	1	4	9.34e-02
GO:BP	GO:0098708	glucose import across plasma membrane	1	5	9.34e-02
GO:BP	GO:0098704	carbohydrate import across plasma membrane	1	5	9.34e-02
GO:BP	GO:0062197	cellular response to chemical stress	3	269	9.34e-02
GO:BP	GO:0061643	chemorepulsion of axon	1	6	9.34e-02
GO:BP	GO:0060252	positive regulation of glial cell proliferation	1	14	9.34e-02
GO:BP	GO:0060251	regulation of glial cell proliferation	1	26	9.34e-02
GO:BP	GO:0051939	gamma-aminobutyric acid import	1	3	9.34e-02
GO:BP	GO:0051764	actin crosslink formation	1	9	9.34e-02
GO:BP	GO:0006979	response to oxidative stress	3	328	9.34e-02
GO:BP	GO:0048232	male gamete generation	2	346	9.34e-02
GO:BP	GO:0014009	glial cell proliferation	1	40	9.34e-02
GO:BP	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	1	7	9.34e-02
GO:BP	GO:0042918	alkanesulfonate transport	1	6	9.34e-02
GO:BP	GO:0008356	asymmetric cell division	1	14	9.34e-02
GO:BP	GO:0014015	positive regulation of gliogenesis	1	44	9.34e-02
GO:BP	GO:0007283	spermatogenesis	2	333	9.34e-02
GO:BP	GO:0007288	sperm axoneme assembly	1	20	9.34e-02
GO:BP	GO:0036159	inner dynein arm assembly	1	8	9.34e-02
GO:BP	GO:0034599	cellular response to oxidative stress	3	218	9.34e-02
GO:BP	GO:0022412	cellular process involved in reproduction in multicellular organism	2	255	9.34e-02
GO:BP	GO:0018345	protein palmitoylation	1	30	9.34e-02
GO:BP	GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	1	21	9.34e-02
GO:BP	GO:0018230	peptidyl-L-cysteine S-palmitoylation	1	21	9.34e-02
GO:BP	GO:0017145	stem cell division	1	25	9.34e-02
GO:BP	GO:0015734	taurine transport	1	6	9.34e-02
GO:BP	GO:0007281	germ cell development	2	194	9.34e-02
GO:BP	GO:0010232	vascular transport	2	72	9.34e-02
GO:BP	GO:1902965	regulation of protein localization to early endosome	1	10	9.34e-02
GO:BP	GO:1902966	positive regulation of protein localization to early endosome	1	10	9.34e-02
GO:BP	GO:1904059	regulation of locomotor rhythm	1	3	9.34e-02
GO:BP	GO:1904350	regulation of protein catabolic process in the vacuole	1	13	9.34e-02
GO:BP	GO:1904351	negative regulation of protein catabolic process in the vacuole	1	5	9.34e-02
GO:BP	GO:1905165	regulation of lysosomal protein catabolic process	1	11	9.34e-02
GO:BP	GO:1905166	negative regulation of lysosomal protein catabolic process	1	5	9.34e-02
GO:BP	GO:1905668	positive regulation of protein localization to endosome	1	14	9.34e-02
GO:BP	GO:0150104	transport across blood-brain barrier	2	72	9.34e-02
GO:BP	GO:1902946	protein localization to early endosome	1	12	9.34e-02
GO:BP	GO:1990708	conditioned place preference	1	2	9.34e-02
GO:BP	GO:0140271	hexose import across plasma membrane	1	5	9.34e-02
GO:BP	GO:1905666	regulation of protein localization to endosome	1	15	9.57e-02
GO:BP	GO:0018198	peptidyl-cysteine modification	1	41	9.78e-02
GO:BP	GO:0045666	positive regulation of neuron differentiation	1	63	9.78e-02
GO:BP	GO:0014013	regulation of gliogenesis	1	66	1.02e-01
GO:BP	GO:0006044	N-acetylglucosamine metabolic process	1	16	1.05e-01
GO:BP	GO:0070286	axonemal dynein complex assembly	1	21	1.10e-01
GO:BP	GO:0015812	gamma-aminobutyric acid transport	1	11	1.10e-01
GO:BP	GO:0120316	sperm flagellum assembly	1	27	1.10e-01
GO:BP	GO:1905146	lysosomal protein catabolic process	1	19	1.10e-01
GO:BP	GO:0070837	dehydroascorbic acid transport	1	7	1.10e-01
GO:BP	GO:0032328	alanine transport	1	13	1.10e-01
GO:BP	GO:0003351	epithelial cilium movement involved in extracellular fluid movement	1	30	1.10e-01
GO:BP	GO:1901334	lactone metabolic process	1	10	1.11e-01
GO:BP	GO:0006858	extracellular transport	1	33	1.11e-01
GO:BP	GO:0010887	negative regulation of cholesterol storage	1	8	1.11e-01
GO:BP	GO:0007039	protein catabolic process in the vacuole	1	22	1.11e-01
GO:BP	GO:0007276	gamete generation	2	465	1.11e-01
GO:BP	GO:0019852	L-ascorbic acid metabolic process	1	10	1.11e-01
GO:BP	GO:1901071	glucosamine-containing compound metabolic process	1	19	1.14e-01
GO:BP	GO:0036010	protein localization to endosome	1	28	1.25e-01
GO:BP	GO:0048609	multicellular organismal reproductive process	2	538	1.27e-01
GO:BP	GO:0106072	negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	1	8	1.30e-01
GO:BP	GO:0044458	motile cilium assembly	1	46	1.34e-01
GO:BP	GO:0042158	lipoprotein biosynthetic process	1	92	1.34e-01
GO:BP	GO:0045664	regulation of neuron differentiation	1	137	1.34e-01
GO:BP	GO:0098739	import across plasma membrane	2	130	1.34e-01
GO:BP	GO:0038003	G protein-coupled opioid receptor signaling pathway	1	5	1.34e-01
GO:BP	GO:0006497	protein lipidation	1	89	1.34e-01
GO:BP	GO:0032504	multicellular organism reproduction	2	558	1.34e-01
GO:BP	GO:0003006	developmental process involved in reproduction	2	603	1.34e-01
GO:BP	GO:0019953	sexual reproduction	2	633	1.43e-01
GO:BP	GO:0035810	positive regulation of urine volume	1	10	1.43e-01
GO:BP	GO:0106070	regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	1	11	1.43e-01
GO:BP	GO:0051382	kinetochore assembly	1	17	1.43e-01
GO:BP	GO:0043951	negative regulation of cAMP-mediated signaling	1	10	1.43e-01
GO:BP	GO:0050769	positive regulation of neurogenesis	1	190	1.43e-01
GO:BP	GO:0006040	amino sugar metabolic process	1	34	1.46e-01
GO:BP	GO:0016202	regulation of striated muscle tissue development	1	13	1.46e-01
GO:BP	GO:0010885	regulation of cholesterol storage	1	13	1.47e-01
GO:BP	GO:0044849	estrous cycle	1	14	1.51e-01
GO:BP	GO:0045475	locomotor rhythm	1	13	1.51e-01
GO:BP	GO:0042157	lipoprotein metabolic process	1	116	1.54e-01
GO:BP	GO:0045662	negative regulation of myoblast differentiation	1	20	1.54e-01
GO:BP	GO:0051962	positive regulation of nervous system development	1	222	1.54e-01
GO:BP	GO:0035082	axoneme assembly	1	54	1.54e-01
GO:BP	GO:0051383	kinetochore organization	1	21	1.54e-01
GO:BP	GO:0000226	microtubule cytoskeleton organization	2	549	1.54e-01
GO:BP	GO:0050435	amyloid-beta metabolic process	1	48	1.61e-01
GO:BP	GO:0010888	negative regulation of lipid storage	1	15	1.63e-01
GO:BP	GO:0048634	regulation of muscle organ development	1	14	1.63e-01
GO:BP	GO:0089718	amino acid import across plasma membrane	1	38	1.67e-01
GO:BP	GO:0010878	cholesterol storage	1	18	1.67e-01
GO:BP	GO:0048843	negative regulation of axon extension involved in axon guidance	1	26	1.67e-01
GO:BP	GO:0042063	gliogenesis	1	244	1.67e-01
GO:BP	GO:0003018	vascular process in circulatory system	2	198	1.67e-01
GO:BP	GO:1901386	negative regulation of voltage-gated calcium channel activity	1	14	1.67e-01
GO:BP	GO:0072348	sulfur compound transport	1	36	1.71e-01
GO:BP	GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress	1	33	1.74e-01
GO:BP	GO:0035809	regulation of urine volume	1	14	1.74e-01
GO:BP	GO:0001578	microtubule bundle formation	1	79	1.74e-01
GO:BP	GO:0050767	regulation of neurogenesis	1	302	1.75e-01
GO:BP	GO:0030317	flagellated sperm motility	1	62	1.78e-01
GO:BP	GO:0043543	protein acylation	1	193	1.78e-01
GO:BP	GO:0034508	centromere complex assembly	1	29	1.78e-01
GO:BP	GO:0015804	neutral amino acid transport	1	43	1.78e-01
GO:BP	GO:0097722	sperm motility	1	62	1.78e-01
GO:BP	GO:0048841	regulation of axon extension involved in axon guidance	1	31	1.78e-01
GO:BP	GO:0006487	protein N-linked glycosylation	1	65	1.81e-01
GO:BP	GO:0043620	regulation of DNA-templated transcription in response to stress	1	38	1.81e-01
GO:BP	GO:1902284	neuron projection extension involved in neuron projection guidance	1	35	1.81e-01
GO:BP	GO:0048846	axon extension involved in axon guidance	1	35	1.81e-01
GO:BP	GO:0015800	acidic amino acid transport	1	39	1.81e-01
GO:BP	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	1	30	1.81e-01
GO:BP	GO:0060294	cilium movement involved in cell motility	1	69	1.81e-01
GO:BP	GO:0010720	positive regulation of cell development	1	318	1.81e-01
GO:BP	GO:0021591	ventricular system development	1	29	1.82e-01
GO:BP	GO:0051960	regulation of nervous system development	1	357	1.82e-01
GO:BP	GO:0022414	reproductive process	2	924	1.82e-01
GO:BP	GO:0060285	cilium-dependent cell motility	1	72	1.82e-01
GO:BP	GO:0001539	cilium or flagellum-dependent cell motility	1	72	1.82e-01
GO:BP	GO:0000003	reproduction	2	933	1.83e-01
GO:BP	GO:0071526	semaphorin-plexin signaling pathway	1	44	2.02e-01
GO:BP	GO:0090181	regulation of cholesterol metabolic process	1	27	2.02e-01
GO:BP	GO:0003013	circulatory system process	3	445	2.03e-01
GO:BP	GO:0030517	negative regulation of axon extension	1	41	2.03e-01
GO:BP	GO:0045595	regulation of cell differentiation	4	1122	2.03e-01
GO:BP	GO:0050919	negative chemotaxis	1	42	2.03e-01
GO:BP	GO:0007017	microtubule-based process	2	757	2.05e-01
GO:BP	GO:0043949	regulation of cAMP-mediated signaling	1	17	2.05e-01
GO:BP	GO:0033048	negative regulation of mitotic sister chromatid segregation	1	45	2.06e-01
GO:BP	GO:1901861	regulation of muscle tissue development	1	34	2.06e-01
GO:BP	GO:0003341	cilium movement	1	97	2.06e-01
GO:BP	GO:1901020	negative regulation of calcium ion transmembrane transporter activity	1	28	2.06e-01
GO:BP	GO:0099111	microtubule-based transport	1	192	2.06e-01
GO:BP	GO:0051301	cell division	1	569	2.06e-01
GO:BP	GO:1902100	negative regulation of metaphase/anaphase transition of cell cycle	1	46	2.06e-01
GO:BP	GO:0045841	negative regulation of mitotic metaphase/anaphase transition	1	45	2.06e-01
GO:BP	GO:0007094	mitotic spindle assembly checkpoint signaling	1	43	2.06e-01
GO:BP	GO:0071174	mitotic spindle checkpoint signaling	1	43	2.06e-01
GO:BP	GO:0010874	regulation of cholesterol efflux	1	31	2.06e-01
GO:BP	GO:0051180	vitamin transport	1	29	2.06e-01
GO:BP	GO:0042755	eating behavior	1	16	2.06e-01
GO:BP	GO:0051985	negative regulation of chromosome segregation	1	46	2.06e-01
GO:BP	GO:0033046	negative regulation of sister chromatid segregation	1	45	2.06e-01
GO:BP	GO:2000816	negative regulation of mitotic sister chromatid separation	1	45	2.06e-01
GO:BP	GO:0071173	spindle assembly checkpoint signaling	1	43	2.06e-01
GO:BP	GO:0009988	cell-cell recognition	1	31	2.06e-01
GO:BP	GO:0007286	spermatid development	1	108	2.06e-01
GO:BP	GO:1905819	negative regulation of chromosome separation	1	46	2.06e-01
GO:BP	GO:0042177	negative regulation of protein catabolic process	1	100	2.06e-01
GO:BP	GO:0031577	spindle checkpoint signaling	1	44	2.06e-01
GO:BP	GO:0048515	spermatid differentiation	1	114	2.06e-01
GO:BP	GO:0007517	muscle organ development	2	279	2.08e-01
GO:BP	GO:0003333	amino acid transmembrane transport	1	70	2.08e-01
GO:BP	GO:0006612	protein targeting to membrane	1	120	2.08e-01
GO:BP	GO:0001755	neural crest cell migration	1	49	2.08e-01
GO:BP	GO:1905953	negative regulation of lipid localization	1	31	2.09e-01
GO:BP	GO:0090497	mesenchymal cell migration	1	51	2.12e-01
GO:BP	GO:0050922	negative regulation of chemotaxis	1	44	2.12e-01
GO:BP	GO:0033047	regulation of mitotic sister chromatid segregation	1	51	2.12e-01
GO:BP	GO:0048512	circadian behavior	1	30	2.14e-01
GO:BP	GO:1901385	regulation of voltage-gated calcium channel activity	1	29	2.15e-01
GO:BP	GO:0006767	water-soluble vitamin metabolic process	1	50	2.15e-01
GO:BP	GO:0045839	negative regulation of mitotic nuclear division	1	53	2.15e-01
GO:BP	GO:0010883	regulation of lipid storage	1	38	2.17e-01
GO:BP	GO:0007622	rhythmic behavior	1	32	2.18e-01
GO:BP	GO:0050771	negative regulation of axonogenesis	1	59	2.20e-01
GO:BP	GO:0010965	regulation of mitotic sister chromatid separation	1	56	2.20e-01
GO:BP	GO:0045661	regulation of myoblast differentiation	1	60	2.20e-01
GO:BP	GO:2001258	negative regulation of cation channel activity	1	31	2.22e-01
GO:BP	GO:0060284	regulation of cell development	1	593	2.27e-01
GO:BP	GO:0045776	negative regulation of blood pressure	1	30	2.27e-01
GO:BP	GO:0051784	negative regulation of nuclear division	1	56	2.27e-01
GO:BP	GO:0051306	mitotic sister chromatid separation	1	59	2.27e-01
GO:BP	GO:0015711	organic anion transport	2	270	2.28e-01
GO:BP	GO:1903170	negative regulation of calcium ion transmembrane transport	1	35	2.28e-01
GO:BP	GO:0045597	positive regulation of cell differentiation	1	618	2.28e-01
GO:BP	GO:0033344	cholesterol efflux	1	41	2.29e-01
GO:BP	GO:0050890	cognition	2	226	2.31e-01
GO:BP	GO:0045744	negative regulation of G protein-coupled receptor signaling pathway	1	36	2.32e-01
GO:BP	GO:0046323	glucose import	1	55	2.38e-01
GO:BP	GO:0014032	neural crest cell development	1	70	2.45e-01
GO:BP	GO:0032371	regulation of sterol transport	1	45	2.45e-01
GO:BP	GO:0032374	regulation of cholesterol transport	1	45	2.45e-01
GO:BP	GO:0000122	negative regulation of transcription by RNA polymerase II	1	744	2.46e-01
GO:BP	GO:1905818	regulation of chromosome separation	1	69	2.46e-01
GO:BP	GO:0019933	cAMP-mediated signaling	1	35	2.46e-01
GO:BP	GO:0090150	establishment of protein localization to membrane	1	258	2.46e-01
GO:BP	GO:0006865	amino acid transport	1	103	2.46e-01
GO:BP	GO:0048864	stem cell development	1	75	2.52e-01
GO:BP	GO:1905039	carboxylic acid transmembrane transport	1	111	2.53e-01
GO:BP	GO:1903825	organic acid transmembrane transport	1	112	2.54e-01
GO:BP	GO:0060271	cilium assembly	1	296	2.62e-01
GO:BP	GO:0006605	protein targeting	1	310	2.62e-01
GO:BP	GO:0014033	neural crest cell differentiation	1	79	2.62e-01
GO:BP	GO:0030516	regulation of axon extension	1	82	2.62e-01
GO:BP	GO:0051304	chromosome separation	1	75	2.62e-01
GO:BP	GO:0051926	negative regulation of calcium ion transport	1	45	2.67e-01
GO:BP	GO:0098916	anterograde trans-synaptic signaling	2	490	2.69e-01
GO:BP	GO:0007268	chemical synaptic transmission	2	490	2.69e-01
GO:BP	GO:0099537	trans-synaptic signaling	2	494	2.71e-01
GO:BP	GO:0045445	myoblast differentiation	1	90	2.73e-01
GO:BP	GO:0044782	cilium organization	1	317	2.73e-01
GO:BP	GO:0007193	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	1	37	2.74e-01
GO:BP	GO:0042632	cholesterol homeostasis	1	58	2.74e-01
GO:BP	GO:0030071	regulation of mitotic metaphase/anaphase transition	1	87	2.74e-01
GO:BP	GO:0045944	positive regulation of transcription by RNA polymerase II	1	918	2.74e-01
GO:BP	GO:0043413	macromolecule glycosylation	1	185	2.74e-01
GO:BP	GO:0035725	sodium ion transmembrane transport	1	112	2.74e-01
GO:BP	GO:0045892	negative regulation of DNA-templated transcription	1	1005	2.74e-01
GO:BP	GO:0007018	microtubule-based movement	1	300	2.74e-01
GO:BP	GO:0048640	negative regulation of developmental growth	1	94	2.74e-01
GO:BP	GO:0044784	metaphase/anaphase transition of cell cycle	1	92	2.74e-01
GO:BP	GO:0007091	metaphase/anaphase transition of mitotic cell cycle	1	91	2.74e-01
GO:BP	GO:0007010	cytoskeleton organization	2	1186	2.74e-01
GO:BP	GO:0032413	negative regulation of ion transmembrane transporter activity	1	52	2.74e-01
GO:BP	GO:0042698	ovulation cycle	1	54	2.74e-01
GO:BP	GO:0061387	regulation of extent of cell growth	1	96	2.74e-01
GO:BP	GO:0008037	cell recognition	1	82	2.74e-01
GO:BP	GO:0055092	sterol homeostasis	1	59	2.74e-01
GO:BP	GO:0006766	vitamin metabolic process	1	75	2.74e-01
GO:BP	GO:0008284	positive regulation of cell population proliferation	1	886	2.74e-01
GO:BP	GO:0006486	protein glycosylation	1	185	2.74e-01
GO:BP	GO:0099536	synaptic signaling	2	512	2.74e-01
GO:BP	GO:0051310	metaphase chromosome alignment	1	87	2.74e-01
GO:BP	GO:0051094	positive regulation of developmental process	1	957	2.74e-01
GO:BP	GO:1902099	regulation of metaphase/anaphase transition of cell cycle	1	88	2.74e-01
GO:BP	GO:1902679	negative regulation of RNA biosynthetic process	1	1014	2.74e-01
GO:BP	GO:0010389	regulation of G2/M transition of mitotic cell cycle	1	94	2.74e-01
GO:BP	GO:0050795	regulation of behavior	1	41	2.74e-01
GO:BP	GO:0050793	regulation of developmental process	5	1813	2.74e-01
GO:BP	GO:2001251	negative regulation of chromosome organization	1	89	2.74e-01
GO:BP	GO:0019915	lipid storage	1	68	2.74e-01
GO:BP	GO:0006836	neurotransmitter transport	1	141	2.74e-01
GO:BP	GO:0032410	negative regulation of transporter activity	1	59	2.75e-01
GO:BP	GO:0008645	hexose transmembrane transport	1	87	2.75e-01
GO:BP	GO:1904659	glucose transmembrane transport	1	84	2.75e-01
GO:BP	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	1	102	2.75e-01
GO:BP	GO:2000026	regulation of multicellular organismal development	1	997	2.75e-01
GO:BP	GO:0033045	regulation of sister chromatid segregation	1	99	2.75e-01
GO:BP	GO:0070085	glycosylation	1	197	2.75e-01
GO:BP	GO:0019218	regulation of steroid metabolic process	1	68	2.75e-01
GO:BP	GO:0051303	establishment of chromosome localization	1	93	2.75e-01
GO:BP	GO:0048675	axon extension	1	108	2.75e-01
GO:BP	GO:0019233	sensory perception of pain	1	39	2.75e-01
GO:BP	GO:0051253	negative regulation of RNA metabolic process	1	1112	2.75e-01
GO:BP	GO:0030182	neuron differentiation	1	1058	2.75e-01
GO:BP	GO:0048468	cell development	2	1950	2.76e-01
GO:BP	GO:0019935	cyclic-nucleotide-mediated signaling	1	52	2.76e-01
GO:BP	GO:0015749	monosaccharide transmembrane transport	1	88	2.76e-01
GO:BP	GO:0008306	associative learning	1	65	2.76e-01
GO:BP	GO:0048699	generation of neurons	1	1120	2.78e-01
GO:BP	GO:1902749	regulation of cell cycle G2/M phase transition	1	105	2.80e-01
GO:BP	GO:1904063	negative regulation of cation transmembrane transport	1	64	2.81e-01
GO:BP	GO:0050000	chromosome localization	1	101	2.81e-01
GO:BP	GO:0045934	negative regulation of nucleobase-containing compound metabolic process	1	1203	2.86e-01
GO:BP	GO:0007088	regulation of mitotic nuclear division	1	99	2.86e-01
GO:BP	GO:0010977	negative regulation of neuron projection development	1	117	2.89e-01
GO:BP	GO:0034219	carbohydrate transmembrane transport	1	95	2.89e-01
GO:BP	GO:0045596	negative regulation of cell differentiation	2	471	2.89e-01
GO:BP	GO:0072657	protein localization to membrane	1	530	2.89e-01
GO:BP	GO:1901019	regulation of calcium ion transmembrane transporter activity	1	70	2.91e-01
GO:BP	GO:0006814	sodium ion transport	1	158	2.92e-01
GO:BP	GO:0051240	positive regulation of multicellular organismal process	1	1103	2.92e-01
GO:BP	GO:0034766	negative regulation of monoatomic ion transmembrane transport	1	70	2.92e-01
GO:BP	GO:0030301	cholesterol transport	1	81	2.92e-01
GO:BP	GO:0120031	plasma membrane bounded cell projection assembly	1	463	2.93e-01
GO:BP	GO:0050768	negative regulation of neurogenesis	1	113	2.93e-01
GO:BP	GO:0007416	synapse assembly	1	153	2.95e-01
GO:BP	GO:1902680	positive regulation of RNA biosynthetic process	1	1305	2.95e-01
GO:BP	GO:0030031	cell projection assembly	1	473	2.95e-01
GO:BP	GO:0051983	regulation of chromosome segregation	1	121	2.95e-01
GO:BP	GO:0022008	neurogenesis	1	1297	2.95e-01
GO:BP	GO:0045893	positive regulation of DNA-templated transcription	1	1298	2.95e-01
GO:BP	GO:0051961	negative regulation of nervous system development	1	119	2.99e-01
GO:BP	GO:0051668	localization within membrane	1	611	3.03e-01
GO:BP	GO:0050770	regulation of axonogenesis	1	139	3.03e-01
GO:BP	GO:0009101	glycoprotein biosynthetic process	1	251	3.03e-01
GO:BP	GO:0007631	feeding behavior	1	51	3.03e-01
GO:BP	GO:0000086	G2/M transition of mitotic cell cycle	1	130	3.06e-01
GO:BP	GO:0015918	sterol transport	1	93	3.09e-01
GO:BP	GO:0007218	neuropeptide signaling pathway	1	36	3.09e-01
GO:BP	GO:0051254	positive regulation of RNA metabolic process	1	1425	3.09e-01
GO:BP	GO:0007093	mitotic cell cycle checkpoint signaling	1	137	3.10e-01
GO:BP	GO:0008643	carbohydrate transport	1	114	3.11e-01
GO:BP	GO:0042752	regulation of circadian rhythm	1	93	3.13e-01
GO:BP	GO:0051783	regulation of nuclear division	1	115	3.13e-01
GO:BP	GO:0032355	response to estradiol	1	79	3.14e-01
GO:BP	GO:0033554	cellular response to stress	1	1662	3.14e-01
GO:BP	GO:0008283	cell population proliferation	2	2340	3.14e-01
GO:BP	GO:0009895	negative regulation of catabolic process	1	287	3.14e-01
GO:BP	GO:0032368	regulation of lipid transport	1	91	3.23e-01
GO:BP	GO:0044839	cell cycle G2/M phase transition	1	145	3.23e-01
GO:BP	GO:0008203	cholesterol metabolic process	1	99	3.23e-01
GO:BP	GO:0045935	positive regulation of nucleobase-containing compound metabolic process	1	1589	3.24e-01
GO:BP	GO:1990138	neuron projection extension	1	149	3.24e-01
GO:BP	GO:0042176	regulation of protein catabolic process	1	328	3.24e-01
GO:BP	GO:0061061	muscle structure development	2	552	3.24e-01
GO:BP	GO:0003014	renal system process	1	76	3.25e-01
GO:BP	GO:0007267	cell-cell signaling	4	1150	3.26e-01
GO:BP	GO:0018193	peptidyl-amino acid modification	1	866	3.26e-01
GO:BP	GO:0034763	negative regulation of transmembrane transport	1	96	3.26e-01
GO:BP	GO:0007015	actin filament organization	1	372	3.26e-01
GO:BP	GO:0008361	regulation of cell size	1	160	3.26e-01
GO:BP	GO:0090090	negative regulation of canonical Wnt signaling pathway	1	114	3.26e-01
GO:BP	GO:0031345	negative regulation of cell projection organization	1	154	3.26e-01
GO:BP	GO:0043271	negative regulation of monoatomic ion transport	1	88	3.26e-01
GO:BP	GO:0006886	intracellular protein transport	1	803	3.26e-01
GO:BP	GO:1902652	secondary alcohol metabolic process	1	106	3.28e-01
GO:BP	GO:0003008	system process	4	1194	3.28e-01
GO:BP	GO:0030308	negative regulation of cell growth	1	161	3.28e-01
GO:BP	GO:0042127	regulation of cell population proliferation	1	1568	3.31e-01
GO:BP	GO:0009100	glycoprotein metabolic process	1	315	3.31e-01
GO:BP	GO:0048870	cell motility	2	1169	3.33e-01
GO:BP	GO:0016125	sterol metabolic process	1	108	3.33e-01
GO:BP	GO:0051129	negative regulation of cellular component organization	2	592	3.34e-01
GO:BP	GO:0008277	regulation of G protein-coupled receptor signaling pathway	1	93	3.34e-01
GO:BP	GO:0046942	carboxylic acid transport	1	213	3.34e-01
GO:BP	GO:0015849	organic acid transport	1	214	3.34e-01
GO:BP	GO:1901991	negative regulation of mitotic cell cycle phase transition	1	165	3.41e-01
GO:BP	GO:0098742	cell-cell adhesion via plasma-membrane adhesion molecules	1	165	3.43e-01
GO:BP	GO:0051172	negative regulation of nitrogen compound metabolic process	1	1832	3.43e-01
GO:BP	GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway	1	71	3.43e-01
GO:BP	GO:2001257	regulation of cation channel activity	1	100	3.43e-01
GO:BP	GO:1905952	regulation of lipid localization	1	110	3.43e-01
GO:BP	GO:0055088	lipid homeostasis	1	116	3.43e-01
GO:BP	GO:0000070	mitotic sister chromatid segregation	1	178	3.48e-01
GO:BP	GO:0006357	regulation of transcription by RNA polymerase II	1	1764	3.48e-01
GO:BP	GO:0050920	regulation of chemotaxis	1	143	3.55e-01
GO:BP	GO:0000075	cell cycle checkpoint signaling	1	184	3.55e-01
GO:BP	GO:0071897	DNA biosynthetic process	1	174	3.57e-01
GO:BP	GO:0007612	learning	1	114	3.57e-01
GO:BP	GO:0006366	transcription by RNA polymerase II	1	1852	3.57e-01
GO:BP	GO:0007399	nervous system development	1	1886	3.57e-01
GO:BP	GO:1901566	organonitrogen compound biosynthetic process	2	1496	3.57e-01
GO:BP	GO:0048588	developmental cell growth	1	194	3.58e-01
GO:BP	GO:0010557	positive regulation of macromolecule biosynthetic process	1	1896	3.65e-01
GO:BP	GO:0030178	negative regulation of Wnt signaling pathway	1	140	3.65e-01
GO:BP	GO:0097485	neuron projection guidance	1	177	3.65e-01
GO:BP	GO:0007411	axon guidance	1	177	3.65e-01
GO:BP	GO:0070887	cellular response to chemical stimulus	1	1857	3.65e-01
GO:BP	GO:0031328	positive regulation of cellular biosynthetic process	1	1958	3.65e-01
GO:BP	GO:0071702	organic substance transport	6	2133	3.65e-01
GO:BP	GO:0051093	negative regulation of developmental process	2	654	3.65e-01
GO:BP	GO:0045926	negative regulation of growth	1	204	3.65e-01
GO:BP	GO:0060560	developmental growth involved in morphogenesis	1	207	3.65e-01
GO:BP	GO:1903829	positive regulation of protein localization	1	392	3.65e-01
GO:BP	GO:0048762	mesenchymal cell differentiation	1	205	3.65e-01
GO:BP	GO:0030334	regulation of cell migration	2	707	3.65e-01
GO:BP	GO:0048863	stem cell differentiation	1	196	3.65e-01
GO:BP	GO:0009891	positive regulation of biosynthetic process	1	1972	3.65e-01
GO:BP	GO:0070925	organelle assembly	1	828	3.66e-01
GO:BP	GO:0010558	negative regulation of macromolecule biosynthetic process	1	1669	3.68e-01
GO:BP	GO:0031327	negative regulation of cellular biosynthetic process	1	1708	3.75e-01
GO:BP	GO:0009890	negative regulation of biosynthetic process	1	1721	3.75e-01
GO:BP	GO:0045930	negative regulation of mitotic cell cycle	1	209	3.82e-01
GO:BP	GO:0000819	sister chromatid segregation	1	217	3.83e-01
GO:BP	GO:1903169	regulation of calcium ion transmembrane transport	1	120	3.87e-01
GO:BP	GO:2000145	regulation of cell motility	2	741	3.87e-01
GO:BP	GO:0051239	regulation of multicellular organismal process	1	2052	3.90e-01
GO:BP	GO:0065004	protein-DNA complex assembly	1	171	3.90e-01
GO:BP	GO:0008217	regulation of blood pressure	1	114	3.90e-01
GO:BP	GO:0010721	negative regulation of cell development	1	190	3.90e-01
GO:BP	GO:0005996	monosaccharide metabolic process	1	212	3.94e-01
GO:BP	GO:0014706	striated muscle tissue development	1	214	3.96e-01
GO:BP	GO:0051173	positive regulation of nitrogen compound metabolic process	1	2367	3.96e-01
GO:BP	GO:0030036	actin cytoskeleton organization	1	566	3.96e-01
GO:BP	GO:0098657	import into cell	2	664	3.96e-01
GO:BP	GO:0050804	modulation of chemical synaptic transmission	1	343	3.98e-01
GO:BP	GO:0099177	regulation of trans-synaptic signaling	1	344	3.98e-01
GO:BP	GO:0040012	regulation of locomotion	2	762	3.98e-01
GO:BP	GO:0033044	regulation of chromosome organization	1	235	3.99e-01
GO:BP	GO:1901988	negative regulation of cell cycle phase transition	1	234	4.06e-01
GO:BP	GO:0030154	cell differentiation	2	2942	4.08e-01
GO:BP	GO:0048869	cellular developmental process	2	2943	4.08e-01
GO:BP	GO:0007623	circadian rhythm	1	160	4.08e-01
GO:BP	GO:0031324	negative regulation of cellular metabolic process	1	2069	4.08e-01
GO:BP	GO:0006936	muscle contraction	1	266	4.14e-01
GO:BP	GO:0060485	mesenchyme development	1	250	4.14e-01
GO:BP	GO:0007626	locomotory behavior	1	139	4.16e-01
GO:BP	GO:0010605	negative regulation of macromolecule metabolic process	1	2131	4.16e-01
GO:BP	GO:0048638	regulation of developmental growth	1	254	4.18e-01
GO:BP	GO:0015031	protein transport	1	1366	4.19e-01
GO:BP	GO:0046907	intracellular transport	1	1440	4.19e-01
GO:BP	GO:0030029	actin filament-based process	1	643	4.20e-01
GO:BP	GO:0140014	mitotic nuclear division	1	251	4.20e-01
GO:BP	GO:0031325	positive regulation of cellular metabolic process	1	2518	4.20e-01
GO:BP	GO:0006355	regulation of DNA-templated transcription	1	2560	4.21e-01
GO:BP	GO:2001141	regulation of RNA biosynthetic process	1	2577	4.22e-01
GO:BP	GO:0010604	positive regulation of macromolecule metabolic process	1	2607	4.24e-01
GO:BP	GO:0043547	positive regulation of GTPase activity	1	211	4.26e-01
GO:BP	GO:0040013	negative regulation of locomotion	1	262	4.26e-01
GO:BP	GO:1901137	carbohydrate derivative biosynthetic process	1	544	4.26e-01
GO:BP	GO:0097435	supramolecular fiber organization	1	666	4.26e-01
GO:BP	GO:0006351	DNA-templated transcription	1	2669	4.26e-01
GO:BP	GO:0034329	cell junction assembly	1	347	4.26e-01
GO:BP	GO:0009892	negative regulation of metabolic process	1	2297	4.26e-01
GO:BP	GO:0045184	establishment of protein localization	1	1468	4.27e-01
GO:BP	GO:0032774	RNA biosynthetic process	1	2699	4.29e-01
GO:BP	GO:0010948	negative regulation of cell cycle process	1	271	4.32e-01
GO:BP	GO:0060828	regulation of canonical Wnt signaling pathway	1	214	4.35e-01
GO:BP	GO:0007188	adenylate cyclase-modulating G protein-coupled receptor signaling pathway	1	113	4.35e-01
GO:BP	GO:0051252	regulation of RNA metabolic process	1	2824	4.42e-01
GO:BP	GO:0050808	synapse organization	1	373	4.43e-01
GO:BP	GO:0098813	nuclear chromosome segregation	1	264	4.43e-01
GO:BP	GO:0006810	transport	2	3294	4.43e-01
GO:BP	GO:0009893	positive regulation of metabolic process	1	2846	4.43e-01
GO:BP	GO:0001822	kidney development	1	246	4.46e-01
GO:BP	GO:0032535	regulation of cellular component size	1	306	4.46e-01
GO:BP	GO:0051056	regulation of small GTPase mediated signal transduction	1	249	4.47e-01
GO:BP	GO:0015850	organic hydroxy compound transport	1	181	4.51e-01
GO:BP	GO:0006950	response to stress	1	2763	4.51e-01
GO:BP	GO:0072001	renal system development	1	253	4.52e-01
GO:BP	GO:0051924	regulation of calcium ion transport	1	167	4.52e-01
GO:BP	GO:0048731	system development	1	2886	4.52e-01
GO:BP	GO:0042221	response to chemical	1	2456	4.53e-01
GO:BP	GO:1901990	regulation of mitotic cell cycle phase transition	1	305	4.53e-01
GO:BP	GO:0003012	muscle system process	1	334	4.53e-01
GO:BP	GO:0051234	establishment of localization	2	3453	4.55e-01
GO:BP	GO:0040011	locomotion	2	854	4.55e-01
GO:BP	GO:0019219	regulation of nucleobase-containing compound metabolic process	1	3059	4.55e-01
GO:BP	GO:0034654	nucleobase-containing compound biosynthetic process	1	3054	4.55e-01
GO:BP	GO:0032412	regulation of monoatomic ion transmembrane transporter activity	1	189	4.56e-01
GO:BP	GO:0018130	heterocycle biosynthetic process	1	3115	4.60e-01
GO:BP	GO:0120036	plasma membrane bounded cell projection organization	1	1203	4.60e-01
GO:BP	GO:0019438	aromatic compound biosynthetic process	1	3116	4.60e-01
GO:BP	GO:0051179	localization	4	3983	4.62e-01
GO:BP	GO:0022898	regulation of transmembrane transporter activity	1	200	4.64e-01
GO:BP	GO:0007611	learning or memory	1	201	4.64e-01
GO:BP	GO:0071705	nitrogen compound transport	1	1689	4.64e-01
GO:BP	GO:0030030	cell projection organization	1	1236	4.64e-01
GO:BP	GO:0010639	negative regulation of organelle organization	1	310	4.64e-01
GO:BP	GO:1901362	organic cyclic compound biosynthetic process	1	3221	4.67e-01
GO:BP	GO:0098662	inorganic cation transmembrane transport	2	537	4.69e-01
GO:BP	GO:0008202	steroid metabolic process	1	203	4.69e-01
GO:BP	GO:0062012	regulation of small molecule metabolic process	1	248	4.69e-01
GO:BP	GO:0001558	regulation of cell growth	1	352	4.69e-01
GO:BP	GO:0060070	canonical Wnt signaling pathway	1	254	4.69e-01
GO:BP	GO:0019932	second-messenger-mediated signaling	1	182	4.69e-01
GO:BP	GO:0001667	ameboidal-type cell migration	1	358	4.69e-01
GO:BP	GO:0051649	establishment of localization in cell	1	1842	4.69e-01
GO:BP	GO:0032102	negative regulation of response to external stimulus	1	291	4.69e-01
GO:BP	GO:0032409	regulation of transporter activity	1	212	4.75e-01
GO:BP	GO:0098655	monoatomic cation transmembrane transport	2	554	4.77e-01
GO:BP	GO:0048511	rhythmic process	1	233	4.77e-01
GO:BP	GO:0010975	regulation of neuron projection development	1	374	4.77e-01
GO:BP	GO:0007409	axonogenesis	1	350	4.77e-01
GO:BP	GO:0032880	regulation of protein localization	1	719	4.77e-01
GO:BP	GO:0045786	negative regulation of cell cycle	1	337	4.77e-01
GO:BP	GO:0043087	regulation of GTPase activity	1	288	4.77e-01
GO:BP	GO:0030111	regulation of Wnt signaling pathway	1	274	4.80e-01
GO:BP	GO:0140694	non-membrane-bounded organelle assembly	1	364	4.80e-01
GO:BP	GO:0006935	chemotaxis	1	264	4.80e-01
GO:BP	GO:0019216	regulation of lipid metabolic process	1	251	4.80e-01
GO:BP	GO:0030001	metal ion transport	2	568	4.80e-01
GO:BP	GO:0051235	maintenance of location	1	263	4.80e-01
GO:BP	GO:0006518	peptide metabolic process	1	781	4.80e-01
GO:BP	GO:0007275	multicellular organism development	1	3355	4.80e-01
GO:BP	GO:0042330	taxis	1	264	4.80e-01
GO:BP	GO:0008104	protein localization	2	2128	4.87e-01
GO:BP	GO:0070727	cellular macromolecule localization	2	2137	4.88e-01
GO:BP	GO:0055085	transmembrane transport	3	1014	4.89e-01
GO:BP	GO:0007059	chromosome segregation	1	360	4.90e-01
GO:BP	GO:0060537	muscle tissue development	1	347	4.90e-01
GO:BP	GO:0006066	alcohol metabolic process	1	263	4.96e-01
GO:BP	GO:0044271	cellular nitrogen compound biosynthetic process	1	3743	4.96e-01
GO:BP	GO:0060341	regulation of cellular localization	1	805	4.97e-01
GO:BP	GO:0009410	response to xenobiotic stimulus	1	275	4.97e-01
GO:BP	GO:0016049	cell growth	1	416	4.97e-01
GO:BP	GO:0051248	negative regulation of protein metabolic process	1	799	4.97e-01
GO:BP	GO:1901987	regulation of cell cycle phase transition	1	387	4.97e-01
GO:BP	GO:0098660	inorganic ion transmembrane transport	2	582	4.97e-01
GO:BP	GO:1904062	regulation of monoatomic cation transmembrane transport	1	232	4.97e-01
GO:BP	GO:0061564	axon development	1	388	4.99e-01
GO:BP	GO:0090066	regulation of anatomical structure size	1	395	4.99e-01
GO:BP	GO:0000280	nuclear division	1	343	4.99e-01
GO:BP	GO:0048585	negative regulation of response to stimulus	3	1267	5.04e-01
GO:BP	GO:0009894	regulation of catabolic process	1	883	5.04e-01
GO:BP	GO:0032501	multicellular organismal process	9	4807	5.04e-01
GO:BP	GO:0044772	mitotic cell cycle phase transition	1	411	5.04e-01
GO:BP	GO:0070588	calcium ion transmembrane transport	1	221	5.10e-01
GO:BP	GO:0016477	cell migration	2	1065	5.10e-01
GO:BP	GO:0030163	protein catabolic process	1	906	5.10e-01
GO:BP	GO:0030335	positive regulation of cell migration	1	408	5.10e-01
GO:BP	GO:1901135	carbohydrate derivative metabolic process	1	841	5.12e-01
GO:BP	GO:0051656	establishment of organelle localization	1	397	5.15e-01
GO:BP	GO:0050878	regulation of body fluid levels	1	237	5.15e-01
GO:BP	GO:0006996	organelle organization	2	2974	5.21e-01
GO:BP	GO:2000147	positive regulation of cell motility	1	421	5.25e-01
GO:BP	GO:0048856	anatomical structure development	2	4100	5.25e-01
GO:BP	GO:0048285	organelle fission	1	387	5.26e-01
GO:BP	GO:0034330	cell junction organization	1	586	5.27e-01
GO:BP	GO:0006869	lipid transport	1	271	5.27e-01
GO:BP	GO:0010468	regulation of gene expression	1	3587	5.27e-01
GO:BP	GO:0040017	positive regulation of locomotion	1	429	5.27e-01
GO:BP	GO:0048667	cell morphogenesis involved in neuron differentiation	1	451	5.27e-01
GO:BP	GO:0007346	regulation of mitotic cell cycle	1	438	5.27e-01
GO:BP	GO:0048523	negative regulation of cellular process	1	3773	5.27e-01
GO:BP	GO:0051171	regulation of nitrogen compound metabolic process	1	4243	5.33e-01
GO:BP	GO:0034220	monoatomic ion transmembrane transport	2	650	5.34e-01
GO:BP	GO:0010556	regulation of macromolecule biosynthetic process	1	3702	5.35e-01
GO:BP	GO:0010959	regulation of metal ion transport	1	271	5.35e-01
GO:BP	GO:0033036	macromolecule localization	1	2448	5.35e-01
GO:BP	GO:0033365	protein localization to organelle	1	860	5.38e-01
GO:BP	GO:0006812	monoatomic cation transport	2	677	5.38e-01
GO:BP	GO:0048522	positive regulation of cellular process	1	4197	5.38e-01
GO:BP	GO:0080090	regulation of primary metabolic process	1	4371	5.40e-01
GO:BP	GO:0031326	regulation of cellular biosynthetic process	1	3794	5.40e-01
GO:BP	GO:0009889	regulation of biosynthetic process	1	3820	5.41e-01
GO:BP	GO:0007264	small GTPase mediated signal transduction	1	413	5.41e-01
GO:BP	GO:0005975	carbohydrate metabolic process	1	439	5.41e-01
GO:BP	GO:0040008	regulation of growth	1	493	5.41e-01
GO:BP	GO:0043603	amide metabolic process	1	1003	5.41e-01
GO:BP	GO:0048519	negative regulation of biological process	1	4026	5.47e-01
GO:BP	GO:0198738	cell-cell signaling by wnt	1	380	5.47e-01
GO:BP	GO:0120035	regulation of plasma membrane bounded cell projection organization	1	529	5.47e-01
GO:BP	GO:0051051	negative regulation of transport	1	317	5.47e-01
GO:BP	GO:0010876	lipid localization	1	309	5.47e-01
GO:BP	GO:0044770	cell cycle phase transition	1	496	5.47e-01
GO:BP	GO:0036211	protein modification process	1	2751	5.47e-01
GO:BP	GO:0048812	neuron projection morphogenesis	1	500	5.47e-01
GO:BP	GO:0016055	Wnt signaling pathway	1	379	5.47e-01
GO:BP	GO:0120039	plasma membrane bounded cell projection morphogenesis	1	515	5.51e-01
GO:BP	GO:0048589	developmental growth	1	522	5.51e-01
GO:BP	GO:0031344	regulation of cell projection organization	1	542	5.51e-01
GO:BP	GO:0048858	cell projection morphogenesis	1	519	5.52e-01
GO:BP	GO:0006816	calcium ion transport	1	275	5.57e-01
GO:BP	GO:0032502	developmental process	2	4445	5.61e-01
GO:BP	GO:0032990	cell part morphogenesis	1	539	5.62e-01
GO:BP	GO:0048518	positive regulation of biological process	1	4566	5.62e-01
GO:BP	GO:0043412	macromolecule modification	1	2948	5.64e-01
GO:BP	GO:0051641	cellular localization	1	2822	5.66e-01
GO:BP	GO:0034765	regulation of monoatomic ion transmembrane transport	1	296	5.66e-01
GO:BP	GO:0051345	positive regulation of hydrolase activity	1	412	5.66e-01
GO:BP	GO:0051640	organelle localization	1	521	5.69e-01
GO:BP	GO:0098609	cell-cell adhesion	1	599	5.73e-01
GO:BP	GO:1901565	organonitrogen compound catabolic process	1	1151	5.73e-01
GO:BP	GO:0009057	macromolecule catabolic process	1	1215	5.80e-01
GO:BP	GO:0051276	chromosome organization	1	533	5.85e-01
GO:BP	GO:1901615	organic hydroxy compound metabolic process	1	375	5.90e-01
GO:BP	GO:0008015	blood circulation	1	372	5.90e-01
GO:BP	GO:0031323	regulation of cellular metabolic process	1	4563	5.91e-01
GO:BP	GO:0060255	regulation of macromolecule metabolic process	1	4593	5.94e-01
GO:BP	GO:0006811	monoatomic ion transport	1	788	5.97e-01
GO:BP	GO:0050877	nervous system process	1	628	5.98e-01
GO:BP	GO:0009059	macromolecule biosynthetic process	2	5148	6.01e-01
GO:BP	GO:1902532	negative regulation of intracellular signal transduction	1	445	6.01e-01
GO:BP	GO:0009968	negative regulation of signal transduction	2	1017	6.01e-01
GO:BP	GO:0032989	cellular component morphogenesis	1	627	6.01e-01
GO:BP	GO:0016070	RNA metabolic process	1	3573	6.01e-01
GO:BP	GO:0010564	regulation of cell cycle process	1	622	6.27e-01
GO:BP	GO:0019222	regulation of metabolic process	1	4998	6.30e-01
GO:BP	GO:0043269	regulation of monoatomic ion transport	1	369	6.35e-01
GO:BP	GO:0051716	cellular response to stimulus	1	4929	6.35e-01
GO:BP	GO:0008285	negative regulation of cell population proliferation	1	643	6.35e-01
GO:BP	GO:0007420	brain development	1	546	6.35e-01
GO:BP	GO:0022603	regulation of anatomical structure morphogenesis	1	680	6.35e-01
GO:BP	GO:0032879	regulation of localization	3	1570	6.37e-01
GO:BP	GO:1903047	mitotic cell cycle process	1	689	6.37e-01
GO:BP	GO:0090304	nucleic acid metabolic process	1	4018	6.37e-01
GO:BP	GO:0034762	regulation of transmembrane transport	1	392	6.37e-01
GO:BP	GO:0023057	negative regulation of signaling	2	1090	6.42e-01
GO:BP	GO:0010648	negative regulation of cell communication	2	1088	6.42e-01
GO:BP	GO:0065003	protein-containing complex assembly	1	1320	6.44e-01
GO:BP	GO:0060322	head development	1	588	6.52e-01
GO:BP	GO:0040007	growth	1	737	6.56e-01
GO:BP	GO:0000902	cell morphogenesis	1	740	6.67e-01
GO:BP	GO:0007610	behavior	1	439	6.69e-01
GO:BP	GO:0006139	nucleobase-containing compound metabolic process	1	4423	6.69e-01
GO:BP	GO:0031175	neuron projection development	1	774	6.78e-01
GO:BP	GO:0046483	heterocycle metabolic process	1	4537	6.81e-01
GO:BP	GO:0044249	cellular biosynthetic process	2	5813	6.82e-01
GO:BP	GO:0006725	cellular aromatic compound metabolic process	1	4561	6.83e-01
GO:BP	GO:0019752	carboxylic acid metabolic process	1	684	6.88e-01
GO:BP	GO:0071824	protein-DNA complex organization	1	711	6.88e-01
GO:BP	GO:1901576	organic substance biosynthetic process	2	5875	6.88e-01
GO:BP	GO:0043436	oxoacid metabolic process	1	699	6.93e-01
GO:BP	GO:0009058	biosynthetic process	2	5912	6.93e-01
GO:BP	GO:0006082	organic acid metabolic process	1	703	6.93e-01
GO:BP	GO:0000278	mitotic cell cycle	1	815	6.93e-01
GO:BP	GO:1901360	organic cyclic compound metabolic process	1	4713	6.93e-01
GO:BP	GO:0032101	regulation of response to external stimulus	1	690	6.94e-01
GO:BP	GO:0019538	protein metabolic process	1	4202	7.03e-01
GO:BP	GO:0009888	tissue development	2	1425	7.03e-01
GO:BP	GO:0034641	cellular nitrogen compound metabolic process	1	4913	7.03e-01
GO:BP	GO:0051241	negative regulation of multicellular organismal process	1	744	7.05e-01
GO:BP	GO:0048513	animal organ development	3	2156	7.10e-01
GO:BP	GO:1901575	organic substance catabolic process	1	1731	7.14e-01
GO:BP	GO:0007155	cell adhesion	1	996	7.15e-01
GO:BP	GO:0043933	protein-containing complex organization	1	1964	7.15e-01
GO:BP	GO:0048666	neuron development	1	873	7.15e-01
GO:BP	GO:0051336	regulation of hydrolase activity	1	680	7.20e-01
GO:BP	GO:0044281	small molecule metabolic process	2	1386	7.20e-01
GO:BP	GO:0050896	response to stimulus	1	5721	7.20e-01
GO:BP	GO:0007417	central nervous system development	1	750	7.30e-01
GO:BP	GO:0006259	DNA metabolic process	1	886	7.30e-01
GO:BP	GO:1902531	regulation of intracellular signal transduction	2	1318	7.32e-01
GO:BP	GO:0010467	gene expression	1	4733	7.32e-01
GO:BP	GO:0051246	regulation of protein metabolic process	1	1895	7.42e-01
GO:BP	GO:0023051	regulation of signaling	4	2560	7.49e-01
GO:BP	GO:0051726	regulation of cell cycle	1	941	7.50e-01
GO:BP	GO:0010646	regulation of cell communication	4	2567	7.50e-01
GO:BP	GO:0051049	regulation of transport	2	1268	7.50e-01
GO:BP	GO:0035556	intracellular signal transduction	3	2036	7.51e-01
GO:BP	GO:0048878	chemical homeostasis	1	689	7.59e-01
GO:BP	GO:0033993	response to lipid	1	594	7.60e-01
GO:BP	GO:0033043	regulation of organelle organization	1	1001	7.60e-01
GO:BP	GO:0022607	cellular component assembly	1	2459	7.60e-01
GO:BP	GO:0014070	response to organic cyclic compound	1	634	7.60e-01
GO:BP	GO:0043085	positive regulation of catalytic activity	1	815	7.60e-01
GO:BP	GO:1901564	organonitrogen compound metabolic process	1	4919	7.60e-01
GO:BP	GO:0009056	catabolic process	1	2108	7.65e-01
GO:BP	GO:0007600	sensory perception	1	259	7.70e-01
GO:BP	GO:0044092	negative regulation of molecular function	1	730	7.72e-01
GO:BP	GO:0044085	cellular component biogenesis	1	2722	7.79e-01
GO:BP	GO:0051128	regulation of cellular component organization	2	1981	7.79e-01
GO:BP	GO:0022402	cell cycle process	1	1078	7.85e-01
GO:BP	GO:0009966	regulation of signal transduction	3	2271	8.26e-01
GO:BP	GO:0006807	nitrogen compound metabolic process	2	7431	8.32e-01
GO:BP	GO:0048583	regulation of response to stimulus	4	2877	8.43e-01
GO:BP	GO:0043170	macromolecule metabolic process	2	7084	8.57e-01
GO:BP	GO:0023052	signaling	7	4134	8.57e-01
GO:BP	GO:0007186	G protein-coupled receptor signaling pathway	1	386	8.57e-01
GO:BP	GO:0044093	positive regulation of molecular function	1	1132	8.57e-01
GO:BP	GO:0006629	lipid metabolic process	1	989	8.57e-01
GO:BP	GO:0007154	cell communication	7	4210	8.69e-01
GO:BP	GO:0050794	regulation of cellular process	1	7632	8.93e-01
GO:BP	GO:0007049	cell cycle	1	1515	8.93e-01
GO:BP	GO:0044238	primary metabolic process	2	7788	8.95e-01
GO:BP	GO:0065009	regulation of molecular function	2	1905	8.99e-01
GO:BP	GO:0050790	regulation of catalytic activity	1	1349	9.03e-01
GO:BP	GO:0042592	homeostatic process	1	1189	9.05e-01
GO:BP	GO:0007166	cell surface receptor signaling pathway	2	1889	9.12e-01
GO:BP	GO:0044237	cellular metabolic process	2	7562	9.22e-01
GO:BP	GO:0050789	regulation of biological process	1	8017	9.26e-01
GO:BP	GO:0016043	cellular component organization	2	5106	9.27e-01
GO:BP	GO:1901700	response to oxygen-containing compound	1	1219	9.35e-01
GO:BP	GO:0071840	cellular component organization or biogenesis	2	5307	9.36e-01
GO:BP	GO:0065008	regulation of biological quality	2	2085	9.37e-01
GO:BP	GO:0009653	anatomical structure morphogenesis	1	1952	9.39e-01
GO:BP	GO:0009605	response to external stimulus	1	1635	9.39e-01
GO:BP	GO:0065007	biological regulation	1	8282	9.47e-01
GO:BP	GO:0007165	signal transduction	5	3803	9.55e-01
GO:BP	GO:0010033	response to organic substance	1	1942	9.90e-01
GO:BP	GO:0008150	biological_process	1	12027	1.00e+00
GO:BP	GO:0071704	organic substance metabolic process	1	8176	1.00e+00
GO:BP	GO:0008152	metabolic process	1	8522	1.00e+00
GO:BP	GO:0009987	cellular process	1	11410	1.00e+00
KEGG	KEGG:05202	Transcriptional misregulation in cancer	1	128	7.07e-02
KEGG	KEGG:05215	Prostate cancer	1	86	7.07e-02
KEGG	KEGG:00510	N-Glycan biosynthesis	1	48	7.29e-02
KEGG	KEGG:05014	Amyotrophic lateral sclerosis	1	303	1.56e-01
KEGG	KEGG:05016	Huntington disease	1	256	1.56e-01
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	1	385	1.68e-01
KEGG	KEGG:04360	Axon guidance	1	162	2.12e-01
KEGG	KEGG:04080	Neuroactive ligand-receptor interaction	1	108	4.86e-01
KEGG	KEGG:01100	Metabolic pathways	1	1146	5.69e-01
KEGG	KEGG:00000	KEGG root term	1	5548	6.01e-01

TRZnomtable24h %>%
  filter(source=="KEGG") %>% 
  mutate_at(.vars = 6, .funs = scientific_format()) %>%
  kable(., caption = "Enrichment of KEGG terms using nominal pvalue TRZ 24hour genes in my data") %>%
  kable_paper("striped", full_width = FALSE) %>%
  kable_styling(
    full_width = FALSE,
    position = "left",
    bootstrap_options = c("striped", "hover")
  ) %>%
  scroll_box(width = "100%", height = "400px")

Enrichment of KEGG terms using nominal pvalue TRZ 24hour genes in my data
source	term_id	term_name	intersection_size	term_size	p_value
KEGG	KEGG:05202	Transcriptional misregulation in cancer	1	128	7.07e-02
KEGG	KEGG:05215	Prostate cancer	1	86	7.07e-02
KEGG	KEGG:00510	N-Glycan biosynthesis	1	48	7.29e-02
KEGG	KEGG:05014	Amyotrophic lateral sclerosis	1	303	1.56e-01
KEGG	KEGG:05016	Huntington disease	1	256	1.56e-01
KEGG	KEGG:05022	Pathways of neurodegeneration - multiple diseases	1	385	1.68e-01
KEGG	KEGG:04360	Axon guidance	1	162	2.12e-01
KEGG	KEGG:04080	Neuroactive ligand-receptor interaction	1	108	4.86e-01
KEGG	KEGG:01100	Metabolic pathways	1	1146	5.69e-01
KEGG	KEGG:00000	KEGG root term	1	5548	6.01e-01

# DAgostres3 <- readRDS("data/DEG-GO/DAgostres3.RDS")
# DAgostres24 <- readRDS("data/DAgostres24.RDS")
# DXgostres <- readRDS("data/DEG-GO/DXgostres.RDS")
# DXgostres24 <- readRDS("data/DEG-GO/DXgostres24.RDS")
# EPgostres <- readRDS("data/DEG-GO/EPgostres.RDS")
# EPgostres24 <- readRDS("data/DEG-GO/EPgostres24.RDS")
# MTgostres <- readRDS("data/DEG-GO/MTgostres.RDS")
# MTgostres24 <- readRDS("data/DEG-GO/MTgostres24.RDS")
# DDEgostres24only <- readRDS("data/DEG-GO/DDEgostres24only.RDS")
# DDEgostres3only <- readRDS("data/DEG-GO/DDEgostres3only.RDS")
# DDEMgostres3 <- readRDS("data/DEG-GO/DDEMgostres3.RDS")
# DDEMgostres24 <- readRDS("data/DEG-GO/DDEMgostres24.RDS")
# TRZresgenes24h  <- readRDS("data/DEG-GO/TRZresgenes24h.RDS") 
# TRZresgenes3h  <- readRDS("data/DEG-GO/TRZresgenes3h.RDS") 
# saveRDS(list3hr,"data/DEG-GO/list3hr.RDS")
# saveRDS(list24hr,"data/DEG-GO/list24hr.RDS")
# list3hr <- list(DAgostres3=DAgostres3,DXgostres=DXgostres,EPgostres=EPgostres,MTgostres=MTgostres,TRZresgenes3h=TRZresgenes3h,DDEgostres3only=DDEgostres3only,DDEMgostres3=DDEMgostres3)
#  list24hr <- list(DAgostres24=DAgostres24,DXgostres24=DXgostres24,EPgostres24=EPgostres24,MTgostres24=MTgostres24,TRZresgenes243h=TRZresgenes24h,DDEgostres24only=DDEgostres24only,DDEMgostres24=DDEMgostres24)

list3hr <- readRDS("data/DEG-GO/list3hr.RDS")
list24hr <- readRDS("data/DEG-GO/list24hr.RDS")
KEGGtrz3 <- c("KEGG:05202", "KEGG:04115", "KEGG:05223", "KEGG:05212","KEGG:05222")
KEGGtrz24 <- c("KEGG:05202", "KEGG:05215", "KEGG:00510")
# testframe <- lapply(list3hr, `[`,'result')

hr3_results <- list3hr |> 
  map(~ .x$result |> dplyr::select(p_value,term_id,term_name,intersection_size))
hr24_results <- list24hr |> 
  map(~ .x$result |> dplyr::select(p_value,term_id,term_name,,intersection_size))

table_3hr <- list_rbind(hr3_results,names_to = "set")%>%
  mutate(log_val = -log10(p_value)) %>% 
  dplyr::filter(term_id %in% KEGGtrz3) %>% 
  mutate(treatment = case_when(set =="DAgostres3"~"DNR",set=="DXgostres" ~ "DOX",set=="EPgostres"~"EPI",set=="MTgostres"~"MTX",set=="TRZresgenes3h"~"TRZ",set=="DDEgostres23only"~"AC",set=="DDEMgostres3"~"TOP2i"))


table_24hr <- list_rbind(hr24_results,names_to = "set") %>%
  mutate(log_val = -log10(p_value))%>% 
  dplyr::filter(term_id %in% KEGGtrz24) %>% 
  mutate(treatment = case_when(set =="DAgostres24"~"DNR",set=="DXgostres24" ~ "DOX",set=="EPgostres24"~"EPI",set=="MTgostres24"~"MTX",set=="TRZresgenes243h"~"TRZ",set=="DDEgostres24only"~"AC",set=="DDEMgostres24"~"TOP2i"))


hr3_results[["TRZresgenes3h"]]  %>% 
    mutate(log_val = -log10(p_value)) %>% 
  dplyr::filter(str_detect(term_id,"^KEGG:")) %>% 
  slice_min(., n=5,order_by=p_value) %>%
    ggplot(., aes(x = log_val, y =reorder(term_name,p_value),col=intersection_size)) +
    geom_point(aes(size = intersection_size)) +
    scale_y_discrete(labels = scales::label_wrap(30))+
  geom_vline(xintercept = (-log10(0.05)), col="red")+
    guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
    ggtitle('TRZ 3 hour nominal DE\n KEGG pathway enrichment') +
    xlab(expression(" -"~log[10]~("nominal p-value")))+
    ylab("KEGG")+
    theme_bw()+
    theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
        axis.title = element_text(size = 15, color = "black"),
        axis.ticks = element_line(linewidth = 1.5),
        # axis.line = element_line(linewidth = 1.5),
        axis.text = element_text(size = 10, color = "black", angle = 0),
        strip.text.x = element_text(size = 12, color = "black", face = "bold"))

Version	Author	Date
87685e2	reneeisnowhere	2023-12-19

hr24_results[["TRZresgenes243h"]]  %>% 
    mutate(log_val = -log10(p_value)) %>% 
  dplyr::filter(str_detect(term_id,"^KEGG:")) %>% 
  slice_min(., n=5,order_by=p_value) %>%
    ggplot(., aes(x = log_val, y =reorder(term_name,p_value), col=intersection_size)) +
    geom_point(aes(size = intersection_size)) +
    scale_y_discrete(labels = scales::label_wrap(30))+
   geom_vline(xintercept = (-log10(0.05)), col="red")+
    guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
    ggtitle('TRZ 24 hour nominal DE\n KEGG pathway enrichment') +
    xlab(expression(" -"~log[10]~("nominal p-value")))+
    ylab("KEGG")+
    theme_bw()+
    theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
        axis.title = element_text(size = 15, color = "black"),
        axis.ticks = element_line(linewidth = 1.5),
        # axis.line = element_line(linewidth = 1.5),
        axis.text = element_text(size = 10, color = "black", angle = 0),
        strip.text.x = element_text(size = 12, color = "black", face = "bold"))

Version	Author	Date
87685e2	reneeisnowhere	2023-12-19

hr3_results[["TRZresgenes3h"]]  %>% 
    mutate(log_val = -log10(p_value)) %>% 
  dplyr::filter(str_detect(term_id,"^GO:")) %>% 
  slice_min(., n=5,order_by=p_value) %>%
    ggplot(., aes(x = log_val, y =reorder(term_name,p_value),col=intersection_size)) +
    geom_point(aes(size = intersection_size)) +
    scale_y_discrete(labels = scales::label_wrap(30))+
  geom_vline(xintercept = (-log10(0.05)), col="red")+
    guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
    ggtitle('TRZ 3 hour nominal DE\n GO:BP enrichment') +
    xlab(expression(" -"~log[10]~("nominal p-value")))+
    ylab("KEGG")+
    theme_bw()+
    theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
        axis.title = element_text(size = 15, color = "black"),
        axis.ticks = element_line(linewidth = 1.5),
        axis.line = element_line(linewidth = 1.5),
        axis.text = element_text(size = 10, color = "black", angle = 0),
        strip.text.x = element_text(size = 12, color = "black", face = "bold"))

Version	Author	Date
87685e2	reneeisnowhere	2023-12-19

hr24_results[["TRZresgenes243h"]]  %>% 
    mutate(log_val = -log10(p_value)) %>% 
  dplyr::filter(str_detect(term_id,"^GO:")) %>% 
  slice_min(., n=4,order_by=p_value) %>%
    ggplot(., aes(x = log_val, y =reorder(term_name,p_value), col=intersection_size)) +
    geom_point(aes(size = intersection_size)) +
    scale_y_discrete(labels = scales::label_wrap(30))+
  geom_vline(xintercept = (-log10(0.05)), col="red")+
    guides(col="none", size=guide_legend(title = "# of intersected \n terms"))+
    ggtitle('TRZ 24 hour nominal DE\n GO:BP enrichment') +
    xlab(expression(" -"~log[10]~("nominal p-value")))+
    ylab("KEGG")+
    theme_bw()+
    theme(plot.title = element_text(size = rel(1.5), hjust = 0.5),
        axis.title = element_text(size = 15, color = "black"),
        axis.ticks = element_line(linewidth = 1.5),
        # axis.line = element_line(linewidth = 1.5),
        axis.text = element_text(size = 10, color = "black", angle = 0),
        strip.text.x = element_text(size = 12, color = "black", face = "bold"))

Version	Author	Date
87685e2	reneeisnowhere	2023-12-19

Link to other pages here:

Knowles and troponin

Other analysis aka after_comments data here

sessionInfo()

R version 4.3.1 (2023-06-16 ucrt)
Platform: x86_64-w64-mingw32/x64 (64-bit)
Running under: Windows 10 x64 (build 19045)

Matrix products: default


locale:
[1] LC_COLLATE=English_United States.utf8 
[2] LC_CTYPE=English_United States.utf8   
[3] LC_MONETARY=English_United States.utf8
[4] LC_NUMERIC=C                          
[5] LC_TIME=English_United States.utf8    

time zone: America/Chicago
tzcode source: internal

attached base packages:
[1] stats     graphics  grDevices utils     datasets  methods   base     

other attached packages:
 [1] qvalue_2.32.0      gprofiler2_0.2.2   RColorBrewer_1.1-3 biomaRt_2.56.1    
 [5] broom_1.0.5        kableExtra_1.3.4   sjmisc_2.8.9       scales_1.2.1      
 [9] ggpubr_0.6.0       cowplot_1.1.1      ggsignif_0.6.4     lubridate_1.9.3   
[13] forcats_1.0.0      stringr_1.5.0      dplyr_1.1.3        purrr_1.0.2       
[17] readr_2.1.4        tidyr_1.3.0        tibble_3.2.1       ggplot2_3.4.4     
[21] tidyverse_2.0.0    workflowr_1.7.1   

loaded via a namespace (and not attached):
  [1] rstudioapi_0.15.0       jsonlite_1.8.7          magrittr_2.0.3         
  [4] farver_2.1.1            rmarkdown_2.25          fs_1.6.3               
  [7] zlibbioc_1.46.0         vctrs_0.6.4             memoise_2.0.1          
 [10] RCurl_1.98-1.13         rstatix_0.7.2           webshot_0.5.5          
 [13] htmltools_0.5.7         progress_1.2.2          curl_5.1.0             
 [16] sass_0.4.7              bslib_0.5.1             htmlwidgets_1.6.2      
 [19] plyr_1.8.9              plotly_4.10.3           cachem_1.0.8           
 [22] whisker_0.4.1           mime_0.12               lifecycle_1.0.4        
 [25] pkgconfig_2.0.3         sjlabelled_1.2.0        R6_2.5.1               
 [28] fastmap_1.1.1           shiny_1.7.5.1           GenomeInfoDbData_1.2.10
 [31] digest_0.6.33           colorspace_2.1-0        AnnotationDbi_1.62.2   
 [34] S4Vectors_0.38.2        ps_1.7.5                rprojroot_2.0.4        
 [37] crosstalk_1.2.0         RSQLite_2.3.3           filelock_1.0.2         
 [40] labeling_0.4.3          fansi_1.0.5             timechange_0.2.0       
 [43] httr_1.4.7              abind_1.4-5             compiler_4.3.1         
 [46] bit64_4.0.5             withr_2.5.2             backports_1.4.1        
 [49] carData_3.0-5           DBI_1.1.3               highr_0.10             
 [52] rappdirs_0.3.3          tools_4.3.1             httpuv_1.6.12          
 [55] glue_1.6.2              callr_3.7.3             promises_1.2.1         
 [58] grid_4.3.1              getPass_0.2-2           reshape2_1.4.4         
 [61] generics_0.1.3          gtable_0.3.4            tzdb_0.4.0             
 [64] data.table_1.14.8       hms_1.1.3               xml2_1.3.5             
 [67] car_3.1-2               utf8_1.2.4              XVector_0.40.0         
 [70] BiocGenerics_0.46.0     pillar_1.9.0            vroom_1.6.4            
 [73] later_1.3.1             splines_4.3.1           BiocFileCache_2.8.0    
 [76] bit_4.0.5               tidyselect_1.2.0        Biostrings_2.68.1      
 [79] knitr_1.45              git2r_0.32.0            IRanges_2.34.1         
 [82] svglite_2.1.2           stats4_4.3.1            xfun_0.41              
 [85] Biobase_2.60.0          stringi_1.7.12          lazyeval_0.2.2         
 [88] yaml_2.3.7              evaluate_0.23           cli_3.6.1              
 [91] xtable_1.8-4            systemfonts_1.0.5       munsell_0.5.0          
 [94] processx_3.8.2          jquerylib_0.1.4         Rcpp_1.0.11            
 [97] GenomeInfoDb_1.36.4     dbplyr_2.3.4            png_0.1-8              
[100] XML_3.99-0.15           parallel_4.3.1          ellipsis_0.3.2         
[103] blob_1.2.4              prettyunits_1.2.0       bitops_1.0-7           
[106] viridisLite_0.4.2       insight_0.19.6          crayon_1.5.2           
[109] rlang_1.1.2             KEGGREST_1.40.1         rvest_1.0.3