Background

Last updated: 2025-07-16

Checks: 2 0

Knit directory: mecfs-dge-analysis/

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R Markdown file: up-to-date

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Repository version: 87e9060

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Ignored files:
    Ignored:    .DS_Store
    Ignored:    .Rhistory
    Ignored:    .Rproj.user/
    Ignored:    .github/.DS_Store
    Ignored:    .test/
    Ignored:    analysis/.DS_Store
    Ignored:    analysis/head.html
    Ignored:    configs/
    Ignored:    data/.DS_Store
    Ignored:    notebooks/
    Ignored:    output/.DS_Store
    Ignored:    output/all-samples-analysis/.DS_Store
    Ignored:    output/all-samples-analysis/batch-correction-limma/
    Ignored:    output/publication-analysis/.DS_Store
    Ignored:    output/publication-analysis/batch-correction-limma/plot-counts/.DS_Store
    Ignored:    output/spta1-analysis/batch-correction-limma/
    Ignored:    output/subgroup-hpp-analysis/.DS_Store
    Ignored:    renv/.DS_Store
    Ignored:    renv/library/
    Ignored:    renv/staging/
    Ignored:    src/

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File	Version	Author	Date	Message
Rmd	87e9060	sdhutchins	2025-07-16	Remove heading.
html	eb546cd	sdhutchins	2025-07-15	Build site.
Rmd	1373f8e	sdhutchins	2025-07-15	Changes to Category.
Rmd	8e529df	sdhutchins	2024-12-23	Remove unused section.
Rmd	01889df	Brandon M. Wilk	2024-12-06	Remove archived analyses.
html	05f5502	sdhutchins	2023-08-16	Build site.
html	482a8a9	sdhutchins	2023-08-09	Build site.
html	752cbf3	sdhutchins	2023-07-27	Update metadata.
html	a3635c9	sdhutchins	2023-07-25	Build site.
html	81e7d95	sdhutchins	2023-07-24	Build site.
html	e555cb2	sdhutchins	2023-07-24	Build site.
html	0b76a23	sdhutchins	2023-07-12	Build site.
html	fad56f5	sdhutchins	2023-07-06	Build site.
html	ae8df0e	sdhutchins	2023-07-06	Build site.
html	53d12da	sdhutchins	2023-07-06	Build site.
html	ad9ce58	sdhutchins	2023-07-01	Build site.
html	597034d	sdhutchins	2023-06-28	Build site.
html	08f6320	sdhutchins	2023-06-28	Build site.
html	37ab164	sdhutchins	2023-06-28	Build site.
Rmd	3009016	sdhutchins	2023-06-28	Add gprofiler.
html	b66bc86	sdhutchins	2023-06-27	Build site.
html	6133d80	sdhutchins	2023-06-23	Build site.
Rmd	df39c69	sdhutchins	2023-06-23	wflow_publish("analysis/")

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a chronic, disabling illness affecting an estimated 1–3 million Americans. It is marked by persistent fatigue, post-exertional malaise, cognitive impairment, pain, and a range of immune, metabolic, and neurological symptoms.

Onset often follows infection or occurs gradually in adulthood. Research has identified biological abnormalities in ME/CFS, including immune dysregulation, altered cytokine profiles, metabolic dysfunction, and neuroinflammation.

Family studies suggest a genetic component, with first-degree relatives of ME/CFS patients at increased risk.

Background

Methods

Bulk RNA-Seq Analysis