Detect clustering of variants near the ends of reads
This annotation detects clustering of evidence for a somatic variant near the ends of reads. To turn on the annotation and the accompanying filter (clustered_read_position), add --enable_clustered_read_position_filter flag in the commandline.
ClusteredReadPosition produces four INFO field annotations. At a given somatic variant site, MEDIAN_LEFT_OFFSET is the median of the number of bases from the left end of the tumor read to the variant. MEDIAN_RIGHT_OFFSET is similar, but counts from the right end of the read. MAD_LEFT_OFFSET and MAD_RIGHT_OFFSET measure the median absolute deviations. The median gives us the offset of a representative read, while the median absolute deviation captures the spread. We filter a variant if MEDIAN_LEFT_OFFSET <= 10 and MAD_LEFT_OFFSET <= 3, or if MEDIAN_RIGHT_OFFSET <= 10 and MAD_RIGHT_OFFSET <= 3.
ClusteredReadPosition is available with MuTect2 only